https://cassyni.com/slides/outline/87ocR6qz3V94bw7qjDz2vq https://cassyni.com/events/87ocR6qz3V94bw7qjDz2vq/abstract https://cassyni-user-files-prod.s3.amazonaws.com/8DbmXpLeGPVqwwZmhTnyAE https://cassyni.com/events/87ocR6qz3V94bw7qjDz2vq?videoPreview=1 Presentation of EAJ Issue 11/2 - December 6thnohttps://cassyni.com/events/87ocR6qz3V94bw7qjDz2vq?videoPreview=12022-12-06T15:00:00+00:001815.2European Actuarial JournalWe present a claims reserving technique that uses claim-specific feature and past payment information in order to estimate claims reserves for individual reported claims. We design one single neural network allowing us to estimate expected future cash flows for every individual reported claim. We introduce a consistent way of using dropout layers in order to fit the neural network to the incomplete time series of past individual claims payments. A proof of concept is provided by applying this model to synthetic as well as real insurance data sets for which the true outstanding payments for reported claims are known. In this paper, we propose an enhanced method for the measurement of profitability of life insurance products. In contrast to most of the existing literature, we consider the development of the insurance contracts over their entire lifetime under the real-world probability measure and distinguish between different sources of capital. We study the pathwise realization of random variables describing shareholder profitability to obtain and analyze their distribution. These distributions are more versatile than single statistics such as expected values since they additionally allow for the analysis of extreme outcomes. Moreover, we specifically consider the strain on shareholders arising from the solvency capital requirement under Solvency II. We use a cost of capital approach based on the explicit computation of the solvency capital requirement and the interrelated capital required from shareholders for each year of the projection period. To demonstrate the feasibility of our profit measures, we provide a concrete application to products with interest rate guarantees including an internal model approach for market risks under Solvency II. Our numerical application shows that our proposed profit measures are particularly suitable for revealing the profitability of different life insurance products in today’s regulatory environment. With the commencement of the Solvency II directive, insurers in the European Union need to provide a projection of their solvency figures into the future (as part of the Own Risk and Solvency Assessment, ORSA). This is a highly complex task since future solvency figures depend on the development of numerous (stochastic) risk factors. The required evaluations are numerically challenging, which in practice forces companies to limit their analyses to only a few selected deterministic scenarios. These deterministic scenarios clearly cannot describe the full probability distribution of a company’s future solvency situation. The focus of this paper is on financial guarantees in participating life insurance products. In particular, we study two major types of interest rate guarantees in life insurance, a maturity guarantee and a (path-dependent) cliquet-style guarantee. In order to derive entire probability distributions of future solvency ratios, we limit the model framework to two sources of risk (a Hull–White model for interest rates and a geometric Brownian motion for stocks). This partly leads to closed-form solutions of the market-consistent valuation of the liabilities, ensures higher accuracy in computations and less numerical effort. Furthermore, the model allows for a detailed analysis of the impact of the different types of interest rate guarantees on the future solvency situation. Our results suggest that the type of guarantee has a significant impact on the long-term solvency of the company. Almost all life and health insurance models in the actuarial literature use either a Markov assumption or a semi-Markov assumption. This paper shows that non-Markov modelling is also feasible and presents suitable numerical and statistical tools for the calculation of prospective and retrospective reserves. A central idea is to base the calculation of reserves on forward and backward transition rates. Feasible estimators for the forward transition rates have been recently suggested in the medical statistics literature. This paper slightly extends them according to insurance needs and newly introduces symmetric estimators for backward transition rates. Only few adjustments are actually needed in the classical insurance formulas when switching from Markov modelling to as-if-Markov evaluations in order to avoid model risk. In his address to the 21st International Congress of Actuaries, the late Professor William S. Jewell pointed out that, for a whole life insurance policy with level premiums payable continuously and a death benefit of constant amount payable at the moment of death, even though the equivalence principle stipulates that the insurer’s expected gain at issue is zero, the insurer’s expected gain at the moment of death of the insured is positive. This seemingly surprising result turns out to be true for more general life insurance policies. We present a simple derivation of and some elaboration on this fact. This short note aims to propose a new comparison measure for life tables: the age shift needed to restore equality of survival chance as measured by the precedence probability. Mortality by household income in France and by generation in Belgium is used as an illustration.https://cassyni-user-files-prod.s3.amazonaws.com/8DbmXpLeGPVqwwZmhTnyAE https://cassyni.com/slides/outline/D4G2mJoM2hkdusi7wk6xi1 https://cassyni.com/events/D4G2mJoM2hkdusi7wk6xi1/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Lg6zsrLPSujpCuzyF7t8ES https://cassyni.com/events/D4G2mJoM2hkdusi7wk6xi1?videoPreview=1 Anthromes, CO2 and Terrestrial Carbon – Session 5: Implications of land use change uncertainties for the CO2-driven natural land sinknohttps://cassyni.com/events/D4G2mJoM2hkdusi7wk6xi1?videoPreview=12023-03-29T15:00:00+00:006658.24The New Phytologist Foundation10.10 - 11.20: Title TBC, Karl-Heinz Erb 11.20 - 11.40: Uncertainties in modelled CO 2 fluxes from land use and land use change, Wolfgang Obermeier 11.40 - 12.00: Translating land-use fluxes for 2001-2020 from global models to national inventories, Giacomo Grassi (presenting remotely) 12.00 - 12.20: Simulating China's carbon dynamics using improved LUCC data: from source to sink, Zhen Yu (presenting remotely) 12.20 - 12.40: How anthrome carbon cycling influences our understanding of the CO2-fertilzation carbon sink, Anthony Walker https://cassyni-user-files-prod.s3.amazonaws.com/Lg6zsrLPSujpCuzyF7t8ES https://cassyni.com/slides/outline/A6z714FhFtp5mg2W67ZFcR https://cassyni.com/events/A6z714FhFtp5mg2W67ZFcR/abstract https://cassyni-user-files-prod.s3.amazonaws.com/RijRZXhD4py8pnfNMhvweW https://cassyni.com/events/A6z714FhFtp5mg2W67ZFcR?videoPreview=1 Data-driven turbulence closures for ocean and climate models: advances and challengesnohttps://cassyni.com/events/A6z714FhFtp5mg2W67ZFcR?videoPreview=12022-02-04T14:00:00+00:003696.76AI Institute in Dynamic SystemsNumerical simulations used for climate projections solve approximations of the governing laws of fluid motions on a grid. Ultimately, uncertainties in climate predictions originate from the poor representation of small-scale processes, such as ocean turbulence and mixing, that are not resolved on the grid of global climate models. The representation of these unresolved processes, also known as closure or parameterization, has been a bottleneck in improving climate simulations. In this talk, I will discuss data-driven ocean turbulence closures for climate simulations based on our recent work. The topics will include using deep learning to learn turbulence models from high-dimensional data, quantifying uncertainties associated with learned representations of turbulence, and discovering closed-form interpretable equations of ocean turbulence models from data. I will highlight advantages and pitfalls as the community is moving towards combining physics-driven and data-driven closures for climate modeling.https://cassyni-user-files-prod.s3.amazonaws.com/RijRZXhD4py8pnfNMhvweW https://cassyni.com/slides/outline/QRAvq2gR8EVJTaMhu2Jdky https://cassyni.com/events/QRAvq2gR8EVJTaMhu2Jdky/abstract https://cassyni-user-files-prod.s3.amazonaws.com/5qHXStR8LpduMJbu7HB1i6 https://cassyni.com/events/QRAvq2gR8EVJTaMhu2Jdky?videoPreview=1 Building a Strong Editorial Boardnohttps://cassyni.com/events/QRAvq2gR8EVJTaMhu2Jdky?videoPreview=12023-02-28T16:30:00+00:003026.6Topics at the heart of our communityFor our first Spotlight On event of the year, we invite Editors-in-Chief to join us for discussions on one of the greatest assets of any journal: its Editorial Board. How can you build a Board that advocates for their communities, helps authors improve their papers, and set up your journal for success?https://cassyni-user-files-prod.s3.amazonaws.com/5qHXStR8LpduMJbu7HB1i6 https://cassyni.com/slides/outline/H1Ss8myYYNBnhYAoLrh1Ju https://cassyni.com/events/H1Ss8myYYNBnhYAoLrh1Ju/abstract https://cassyni-user-files-prod.s3.amazonaws.com/RKoNiPi34o2oAqRF6GJmdG https://cassyni.com/events/H1Ss8myYYNBnhYAoLrh1Ju?videoPreview=1 Sparse Identification of Nonlinear Dynamics (SINDy): Sparse Machine Learning Models 5 Years Later!nohttps://cassyni.com/events/H1Ss8myYYNBnhYAoLrh1Ju?videoPreview=12021-08-27T12:00:00+00:001445.2Brunton LabMachine learning is enabling the discovery of dynamical systems models and governing equations purely from measurement data. Five years after the original SINDy paper, we revisit this topic, describing the algorithm and exploring the main challenges for computing sparse nonlinear models from data. This is part of a multi-part series. SLB acknowledges support from the National Science Foundation AI Institute in Dynamic Systems (grant number 2112085).https://cassyni-user-files-prod.s3.amazonaws.com/RKoNiPi34o2oAqRF6GJmdG https://cassyni.com/events/KUgtNCDAjexH4UeMtYbe2q/abstract https://cassyni-user-files-prod.s3.amazonaws.com/2gY7RWGBQPXxh4NwSrPqMx https://cassyni.com/events/KUgtNCDAjexH4UeMtYbe2q?videoPreview=1 Beyond Sentiment Analysis: Developing Effective Methods for Specific Emotion Analysis in Marketing Using Machine Learning and Big Datanohttps://cassyni.com/events/KUgtNCDAjexH4UeMtYbe2q?videoPreview=12023-03-08T01:00:00+00:003635.76Department of MarketingThe rise of social networking services has led to a significant increase in user-generated content and electronic word-of-mouth, prompting marketing researchers to focus on sentiment analysis. However, the traditional approach of categorizing emotions as positive or negative has its limitations. Our papers propose an interdisciplinary approach that uses machine learning algorithms and big data to overcome these limitations and detect specific emotions. The thesis presents four papers that go beyond the traditional sentiment analysis, using ML algorithms to analyze large amounts of online text and detect specific emotions. The results show that this approach is effective in predicting customer behavior and attitudes, such as finding relationships between brands, predicting donation behavior, and analyzing social phenomena. Four papers contribute to both marketing and engineering knowledge, as it proposes a more effective approach to specific emotion analysis that goes beyond the traditional positive/negative sentiment analysis. It also uses state-of-the-art ML algorithms to automate the detection of specific emotions in large amounts of online text. Overall, this thesis will provide insights for marketers to understand their customers' emotions and motivations more effectively, enabling them to develop more targeted and effective marketing strategies to drive engagement and conversions.https://cassyni-user-files-prod.s3.amazonaws.com/2gY7RWGBQPXxh4NwSrPqMx https://cassyni.com/slides/outline/SPmM1mGWt4i4ZHdwFzAaBX https://cassyni.com/events/SPmM1mGWt4i4ZHdwFzAaBX/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Bw5VXUJmmnYBDAj6jtgVgJ https://cassyni.com/events/SPmM1mGWt4i4ZHdwFzAaBX?videoPreview=1 Towards a framework for attributing tropical and Mediterranean cyclones to climate changenohttps://cassyni.com/events/SPmM1mGWt4i4ZHdwFzAaBX?videoPreview=12023-02-15T03:00:00+00:002829.64Mechanical EngineeringIn this presentation, I will delve into the ongoing efforts towards creating a framework for attributing tropical and Mediterranean cyclones to climate change. I will be discussing the relationship between climate change and the frequency, intensity, and spatial distribution of these cyclones, and how this information can be used to better understand the causes and consequences of these weather events. I will also touch upon the challenges and limitations that come with attributing cyclones to climate change and the significance of this research for improving predictions and informing adaptation strategies. My aim is to provide valuable insights for researchers, policymakers, and stakeholders in the fields of climate science and disaster risk management.https://cassyni-user-files-prod.s3.amazonaws.com/Bw5VXUJmmnYBDAj6jtgVgJ https://cassyni.com/slides/outline/StQx4Sv3KXG7Z4AprRTNSq https://cassyni.com/events/StQx4Sv3KXG7Z4AprRTNSq/abstract https://cassyni-user-files-prod.s3.amazonaws.com/FFhWW61drtGAt6srFdgZ4S https://cassyni.com/slides/outline/NSc8kvcCmmCdv6sf9SWyDF https://cassyni.com/events/NSc8kvcCmmCdv6sf9SWyDF/abstract https://cassyni-user-files-prod.s3.amazonaws.com/KHW5jSD4q5XUyR41qd91tJ https://cassyni.com/events/NSc8kvcCmmCdv6sf9SWyDF?videoPreview=1 Biological physics of chromatin structure and dynamicsnohttps://cassyni.com/events/NSc8kvcCmmCdv6sf9SWyDF?videoPreview=12021-06-22T09:00:00+00:005180.92Journal of Biological PhysicsInside cell nuclei in eukaryotic organisms, genomic DNA is packaged into arrays of nucleosomes. Each fully wrapped nucleosome consists of 147 base pairs of DNA wrapped around a histone octamer core. The resulting complex of DNA with histones and other proteins forms a multi-scale structure called chromatin. At the most fundamental level of chromatin organization, arrays of nucleosomes form 10-nm fibers that are thought to resemble beads on a string. Chromatin fibers fold into higher-order structures which ultimately make up functional chromosomes. Depending on the organism and the cell type, 75-90% of genomic DNA is packaged into nucleosomes. The question of how various cellular functions such as gene transcription are carried out on the chromatin template is an outstanding puzzle in eukaryotic biology. In this talk, I will discuss recent advances in understanding fundamental biophysical mechanisms of chromatin equilibrium and non-equilibrium dynamics. In particular, I will demonstrate that in baker's yeast, neighboring nucleosomes invade each other's territories through DNA unwrapping and translocation, or through initial assembly in partially wrapped states. Thus, the classic 'beads-on-a-string' picture of well-positioned, non-overlapping nucleosomes must be supplanted by a more dynamic view in which nucleosomes, aided by chromatin remodelers, transiently assemble and disassemble, translocate, and interact with each other and with other chromatin components such as regulatory factors and transcriptional machinery.https://cassyni-user-files-prod.s3.amazonaws.com/KHW5jSD4q5XUyR41qd91tJ https://cassyni.com/events/HW86J68xPBfcX1AK8xoyV7/seminar/qa https://cassyni.com/slides/outline/HW86J68xPBfcX1AK8xoyV7 https://cassyni.com/events/HW86J68xPBfcX1AK8xoyV7/abstract https://cassyni-user-files-prod.s3.amazonaws.com/96p32c7pkP9JTi4SP2pbDx https://cassyni.com/events/HW86J68xPBfcX1AK8xoyV7?videoPreview=1 Advances in applying persulfates for sequestering and analyzing organic contaminantsnohttps://cassyni.com/events/HW86J68xPBfcX1AK8xoyV7?videoPreview=12023-05-25T08:00:00+00:003660.28ElsevierPersulfate-based advanced oxidation processes (Persulfate-AOPs) have been extensively explored because of their powerful capability and wide adaptability in decontamination. For practical applications of Persulfate-AOPs in decontamination, however, there are still many challenges to solve, for instance, to explore the contribution of various reactive oxidizing species (ROS) to the oxidation of target compounds, to reveal the pH-dependent performance of Persulfate-AOPs, and to develop real-time quantification technique for various ROS. Moreover, the high cost of Persulfate-AOPs in decontamination has a restricted application to only specific scenarios. Therefore, it makes sense to expand the applications of Persulfate-AOPs to other fields considering the huge advantage of Persulfate-AOPs in generating ROS with strong oxidation ability. Recently, our research group have made some progress surrounding the above-mentioned challenges and opportunities. Firstly, multiple ROS (Fe(IV), SO4•−, and HO•) were demonstrated to be involved in the Fe(II)-activated persulfates processes (i.e., Fe(II)/PDS process and Fe(II)/PMS process) by using multiple probes. The pH-dependent performance of the Fe(II)/PDS process resulted from the more and more significant scavenging effect of Fe(II) on Fe(IV) with increasing pH. Secondly, naproxen (NAP) was employed as a turn-on luminescent probe for real-time quantification of SO4•− in Persulfate-AOPs. Since chemiluminescence yield of the reaction of NAP with SO4•− was much greater than that with HO•, the developed CL method worked well in selective quantification of SO4•− in various Persulfate-AOPs. Thirdly, benefitting from the rapid generation of SO4•− in the Fe(II)/PMS system and the high reactivity of SO4•− towards NAP as a CL probe, a surrogate for total organic carbon (TOC) based on the determination of CL quenching capacity (CLQC) of organics in the Fe(II)/PMS-NAP system was developed. The developed CL method can provide a TOC value within several seconds by determining the CLQC of wastewater with Fe(II)/PMS-NAP system. In summary, our research group focused on the exploration of reaction mechanism of Persulfate-AOPs, the development of CL method for selectively real-time quantification of SO4•−, and the employment of Persulfate-AOPs to the assessment of wastewater quality.https://cassyni-user-files-prod.s3.amazonaws.com/96p32c7pkP9JTi4SP2pbDx https://cassyni.com/slides/outline/YKaDgbYhYvGxmcsgf1HLMB https://cassyni.com/events/YKaDgbYhYvGxmcsgf1HLMB/abstract https://cassyni-user-files-prod.s3.amazonaws.com/VaBY64b5FqYprKF1h2169C https://cassyni.com/events/YKaDgbYhYvGxmcsgf1HLMB?videoPreview=1 Same but different. Incidental and symptomatic lower grade gliomas show differences in molecular features and survivalnohttps://cassyni.com/events/YKaDgbYhYvGxmcsgf1HLMB?videoPreview=12023-05-15T20:00:00+00:00868.84Journal of Neuro-OncologyJoin Dr. Randy D'Amico and Dr. Jason Sheehan from the Journal of Neuro-Oncology for a conversation with Dr. Christian F. Freyschlag, Dr. Matthias Demetz and Dr. Aleksandrs Krigers, PhD from the Medical University of Innsbruck about their recent journal article on incidental and symptomatic lower grade gliomas and how they show differences in molecular features and survival. https://cassyni-user-files-prod.s3.amazonaws.com/VaBY64b5FqYprKF1h2169C https://cassyni.com/slides/outline/Wqf2fB81duYMEDWNThPoHw https://cassyni.com/events/Wqf2fB81duYMEDWNThPoHw/abstract https://cassyni-user-files-prod.s3.amazonaws.com/HWiTFfxBdQCmYC8rbN985k https://cassyni.com/events/Wqf2fB81duYMEDWNThPoHw?videoPreview=1 Can You Trust Your Compiler? Recent Developments in Automated Testing of Compilation and Verification Toolsnohttps://cassyni.com/events/Wqf2fB81duYMEDWNThPoHw?videoPreview=12023-09-12T11:30:00+00:001770.68HiPEDS CentreCompilers are fundamental to software development, formal verification tools are well established for building trust in hardware designs, and formal verification is increasingly gaining traction in the world of software. The importance of compilers and verifiers mean that bugs in these tools are potentially very serious. I will give an overview of the state-of-the-art in techniques for using randomized testing - also known as “fuzzing” - for finding bugs in compilers and verifiers automatically, focusing on three case studies arising from work my research group and collaborators: automated testing of graphics shader compilers (which led to the formation of a startup company, GraphicsFuzz, that was acquired by Google), automated testing of a verifying compiler for the Dafny programming language, and automated testing of equivalence checking tools for hardware designs.https://cassyni-user-files-prod.s3.amazonaws.com/HWiTFfxBdQCmYC8rbN985k https://cassyni.com/events/CkmtAJXJSKNffWHw16ht9/seminar/qa https://cassyni.com/slides/outline/CkmtAJXJSKNffWHw16ht9 https://cassyni.com/events/CkmtAJXJSKNffWHw16ht9/abstract https://cassyni-user-files-prod.s3.amazonaws.com/KQasix8GDoDMVGzbM8si1U https://cassyni.com/events/CkmtAJXJSKNffWHw16ht9?videoPreview=1 Combining Theodorsen's and impulse theories to predict the lift of large-amplitude pitching foilsnohttps://cassyni.com/events/CkmtAJXJSKNffWHw16ht9?videoPreview=12023-12-05T15:00:00+00:003316.64Experiments in FluidsThe prediction of the unsteady aerodynamic lift experienced by a streamlined body is critical for a wide range of applications including, for instance, the control of aerial vehicles. Closed-form analytical formulations, such as Theodorsen’s lift formula for a sinusoidally pitching plate, have been found accurate for thin aerofoils at small angles of attack. In this talk, we will show that Theodorsen’s formulation can provide an accurate prediction even for non-sinusoidal large-amplitude pitching kinematics resulting in flow separation. The model fails when the interaction between the shed leading- and trailing-edge vortices provide a significant lift contribution, which is not accounted by the model. We compute this lift contribution from the measurements of the rate of change of the impulse of the vortex pair with particle image velocimetry, and we show that it accounts for the difference between the measured and predicted total lift. We also attempt with some degree of success a semi-empirical predictive model of this lift contribution to improve Theodorsen’s model prediction for highly separated flow. Overall, the results provide new insights on the accuracy of Theodorsen’s theory, and paves the way to the development of predictive models for unsteady loads in massively separated flow. https://cassyni-user-files-prod.s3.amazonaws.com/KQasix8GDoDMVGzbM8si1U https://cassyni.com/slides/outline/hS13UTw9FoCV8Voj7Dg4M https://cassyni.com/events/hS13UTw9FoCV8Voj7Dg4M/abstract https://cassyni-user-files-prod.s3.amazonaws.com/GUWVe9nmWSGAxcpDAHCf2v https://cassyni.com/events/hS13UTw9FoCV8Voj7Dg4M?videoPreview=1 Introducing Transformative Plant Biotechnology: Panel discussion session: policy and regulation – the impact on researchnohttps://cassyni.com/events/hS13UTw9FoCV8Voj7Dg4M?videoPreview=12023-09-21T14:30:00+00:002142.24The New Phytologist FoundationChair: Claire Halpin Jonathan Jones, Cathie Martin. Johnathan Napier, Reynante Ordoniohttps://cassyni-user-files-prod.s3.amazonaws.com/GUWVe9nmWSGAxcpDAHCf2v https://cassyni.com/slides/outline/Qur9zLqpy3yT1agn6qfhu7 https://cassyni.com/events/Qur9zLqpy3yT1agn6qfhu7/abstract https://cassyni-user-files-prod.s3.amazonaws.com/2Yg9fvBwsUjXUfm7e6ZUuU https://cassyni.com/events/Qur9zLqpy3yT1agn6qfhu7?videoPreview=1 The investment of time: Two theses on the value of higher educationnohttps://cassyni.com/events/Qur9zLqpy3yT1agn6qfhu7?videoPreview=12023-06-22T13:00:00+00:001369.4Building Digital Education AssetsThis webinar will explore different stakeholder perspectives on the value of higher education. EdTech investors and companies have promoted the need for disruption of existing education markets. This webinar will argue that the value these markets continue to provide to individuals and families makes education resistant to disruption.https://cassyni-user-files-prod.s3.amazonaws.com/2Yg9fvBwsUjXUfm7e6ZUuU https://cassyni.com/events/TP6BDm5TALjwNXALeXaLd3/abstract https://cassyni-user-files-prod.s3.amazonaws.com/NdgyUdVN7rd24cb2EWWGNA https://cassyni.com/slides/outline/2gfxuajDDT3zD4sc8JzEwP https://cassyni.com/events/2gfxuajDDT3zD4sc8JzEwP/abstract https://cassyni-user-files-prod.s3.amazonaws.com/LHDeeDPpgq1tqZ5DpNAK5Q https://cassyni.com/events/2gfxuajDDT3zD4sc8JzEwP?videoPreview=1 What can science deliver?nohttps://cassyni.com/events/2gfxuajDDT3zD4sc8JzEwP?videoPreview=12023-05-24T12:00:00+00:004650.48Stout Research Centre for New Zealand StudiesIn this seminar, Ken, Mahina-a-rangi and Mike will discuss how we understand the state of our water and what we need from to know to manage it properly. Are our science and knowledge systems are fit for purpose?https://cassyni-user-files-prod.s3.amazonaws.com/LHDeeDPpgq1tqZ5DpNAK5Q https://cassyni.com/slides/outline/PvdpEs6SJDe7NoS3VbVCy3 https://cassyni.com/events/PvdpEs6SJDe7NoS3VbVCy3/abstract https://cassyni-user-files-prod.s3.amazonaws.com/LUzo8b3juCVaGfJ5ENXCwx https://cassyni.com/events/PvdpEs6SJDe7NoS3VbVCy3?videoPreview=1 Modeling the internal dynamics of Jupiter. Success and challengesnohttps://cassyni.com/events/PvdpEs6SJDe7NoS3VbVCy3?videoPreview=12022-03-31T12:00:00+00:002978.32Leeds Institute for Fluid DynamicsNo abstracthttps://cassyni-user-files-prod.s3.amazonaws.com/LUzo8b3juCVaGfJ5ENXCwx https://cassyni.com/slides/outline/DYwFvcxksXETjLhdjrDvtD https://cassyni.com/events/DYwFvcxksXETjLhdjrDvtD/abstract https://cassyni-user-files-prod.s3.amazonaws.com/GqtSwQrRn6ogQNRvFNWoBC https://cassyni.com/events/DYwFvcxksXETjLhdjrDvtD?videoPreview=1 Session 2nohttps://cassyni.com/events/DYwFvcxksXETjLhdjrDvtD?videoPreview=12023-07-02T08:15:00+00:004860.52New Phytologist Foundation Plants are growing in a nutrient-poor environment in nature. Agricultural production is heavily relying on the application of chemical fertilizers, imposing a serious economic and environmental problem worldwide. One solution would be to breed crops that can tolerate low-nutrient soils to reduce the reliance on fertilizers. Work in Luan laboratory identified a CBL-CIPK signaling pathway that regulates the activity of a voltage-gated potassium channel involved in K-uptake in plant roots and another CBL-CIPK pathway for vacuolar K remobilization. Manipulation of CBL-CIPK network can potentially enhance the growth of plants under low-K soils, supporting sustainable agriculture and environment. The CBL-CIPK network has become a major signaling mechanism for the regulation of mineral nutrition by targeting transporters in various subcellular locations. The phytohormone abscisic acid (ABA) is crucial for plant responses to environmental challenges. The SNF1-regulated protein kinase 2s (SnRK2s) are key components in ABA-receptor coupled core signaling. It is rapidly phosphorylated and activated by ABA. Early work proved SnRK2 could activate itself by auto-phosphorylation, after ABA mediates SnRK2 release from its inhibitor complex PP2C-SnRK2. Recent studies have suggested that Raf-like protein kinases (RAFs) could phosphorylate SnRK2 and participate in ABA-triggered SnRK2 activation. Thus, how SnRK2 kinases are quickly activated during ABA signaling still needs to be clarified. Here, we used ATP analog and corresponding mutated SnRK2 to label the phosphorylation on SnRK2. The result showed that both B2/3 RAFs directly phosphorylate SnRK2.6 in the kinase activation loop. This trans-phosphorylation by RAFs stimulated SnRK2 activation, and the activated SnRK2s then intermolecularly trans-phosphorylate other SnRK2s that are not yet activated. No RAF kinases will fail the initiate of SnRK2 activation, and genetic evidence has proved that high-order Arabidopsis mutants lacking multiple B2 and B3 RAFs show ABA hyposensitivity and SnRK2 inactivation. So, our findings revealed a unique initiation and amplification mechanism of SnRK2 activation by which RAF participate in ABA signaling. AtAGO1 and AtAGO7 are the main effectors of post-transcriptional gene silencing in Arabidopsis. At AGO7 is a crucial component of the tasiRNA biogenesis pathway, which plays a crucial role in the development of leaf, flower, and root systems by targeting the auxin response factors AtARF3/4 for silencing. We conducted a proximity labelling study and found that AtFIM5, an actin-associated protein, is highly abundant in the vicinity of AtAGO7. Given that the tasiRNA biogenesis machinery localizes to the membraneless siRNA bodies that move along the actin cytoskeleton, we investigated the potential role of AtFIM5 in siRNA body dynamics. We found that AtFIM5 localization is stress-responsive and changes in AtFIM5 behaviour impact on siRNA bodies shape and movement. Additionally, we identified several putative AtAGO7 interactors that colocalize with siRNA bodies and have the potential to generate liquid-liquid phase-separated condensates. Our research aims to understand the impact of stress onto siRNA body dynamics, composition, and fluidity. We believe that unravelling the fine regulation of these condensates will shed light on long-standing questions such as how the biogenesis of secondary sRNA is favoured over RNA degradation. The integration of stress biology into tasi RNA metabolism may pave the way for innovative breeding strategies for more resilient crops. Stomata, the epidermal pores for gas exchange between plants and the atmosphere, are the major sites of water loss. During water shortage, plants limit the formation of new stoma via the phytohormone abscisic acid (ABA) to conserve water. However, how ABA suppresses stomatal production is largely unknown. Here, we demonstrate that three core SnRK2 kinases of ABA signaling inhibit the initiation and proliferation of the stomatal precursors in Arabidopsis. We show that the SnRK2s function within the precursors and directly phosphorylate SPEECHLESS (SPCH), the master transcription factor for stomatal initiation. We identify specific SPCH residues targeted by the SnRK2s, which mediate the ABA/drought-induced suppression of SPCH and stomatal production. This SnRK2-specific SPCH phosphocode connects stomatal development with ABA/drought signals and enables the independent control of this key water conservation response. Our work also highlights how distinct signaling activities can be specifically encoded on a master regulator to modulate developmental plasticity. This talk will not be available to watch on demand Epigenetic regulation of memory has been well studied mechanism in eukaryotes. However, the ability of plants to epigenetically encode prior stress (i.e. stress memory) has only recently been reported. The current state-of-the art research supports the hypothesis that different epigenetic mechanisms play an important role in stress memory and regulation of response upon subsequent stress events. However, the capacity to epigenetically encode flooding stress memory has not been described in plants. In order to understand the stress memory encoding mechanisms, we performed an RNA-Seq of Arabidopsis thaliana wild type and VERNALIZATION2 (VRN2) mutant plants. VRN2 is a regulator of plant chromatin signature whose mutant lacks flooding stress memory. Our preliminary results describe a transcriptional switch caused by priming stress that leads to a more targeted response upon subsequent flooding stress. This apparent encoding of the stress memory relies on several families of transcription factors (TFs). These TFs regulate the expression of a variety of tolerance genes that show flooding memory behaviour. Moreover, some of these tolerance genes are dependent on VRN2, connecting epigenetic regulation to stress memory. Collectively, genes showing memory of previous flooding events can be an important tool for improvement of future crops, ultimately responding to global food security crisis.https://cassyni-user-files-prod.s3.amazonaws.com/GqtSwQrRn6ogQNRvFNWoBC https://cassyni.com/events/A6Q2bqS5oKMpheQ56BqyMP/seminar/qa https://cassyni.com/slides/outline/A6Q2bqS5oKMpheQ56BqyMP https://cassyni.com/events/A6Q2bqS5oKMpheQ56BqyMP/abstract https://cassyni-user-files-prod.s3.amazonaws.com/RmZfhC6kvpHuW2yfmUB5Se https://cassyni.com/events/A6Q2bqS5oKMpheQ56BqyMP?videoPreview=1 Towards zero environmental impact aviationnohttps://cassyni.com/events/A6Q2bqS5oKMpheQ56BqyMP?videoPreview=12023-09-07T12:00:00+00:003349.48Brahmal Vasudevan Institute for Sustainable AviationCivil aviation is a rapidly growing mode of transportation, one that has long time constants, and one that is extremely tough to decarbonize. In addition, aviation is unique in that emissions occur at high altitude, and this provides for a mechanism by which aviation emissions cause around twice the warming that the same emissions on the surface would cause. This talk will outline the long-term environmental challenges facing aviation and how we can move towards a zero environmental impact aviation sector. Parts of the solution discussed will focus on: (1) the fuel-energy system, where various alternative fuel options are being considered (including hydrogen and sustainable aviation fuels), (2) operational measures that can mitigate contrail warming from aviation, and (3) a potential way to apply emissions control technology from ground transportation to aviation that could reduce >90% of the air pollution impacts of aviation. Finally, the talk will move from addressing the climate and air pollution challenges of today's civil aviation to preempting the noise challenge of future drone services such as aerial package delivery. In particular the prospects for "solid state" propulsion for drones will be discussed.https://cassyni-user-files-prod.s3.amazonaws.com/RmZfhC6kvpHuW2yfmUB5Se https://cassyni.com/slides/outline/CZe3qFfhzc8K4asddskc5K https://cassyni.com/events/CZe3qFfhzc8K4asddskc5K/abstract https://cassyni-user-files-prod.s3.amazonaws.com/6qQa5DJoNWbJGNXUN44irz https://cassyni.com/events/CZe3qFfhzc8K4asddskc5K?videoPreview=1 Analytic Theory for Secular Lunisolar Resonancesnohttps://cassyni.com/events/CZe3qFfhzc8K4asddskc5K?videoPreview=12022-09-06T12:35:00+00:00996.72Celestial Mechanics and Dynamical AstronomyInclination dependent lunisolar resonances occur whenever there is a commensurability relationship between the argument of perigee and the longitude of the nodes of a space debris and the perturbing bodies. They shape the dynamics of a MEO object (navigation satellite or space debris) over secular timescales (i.e. several decades). Exploiting such resonances has also been proposed as an efficient and cost-effective strategy for the End-of-Life (EoL) disposal of satellites. This is based on the eccentricity growth along the hyperbolic directions of the phase space, leading to fast re-entry. Our approach improves on the heuristic estimates of previous works. by providing a precise analytical calculation of the borders of the separatrices of the resonances. These results are then compared with a numerical cartography obtained by the FLI. We find that our analytical approach provides an excellent approximation for a wide range of values of the semi-major axis. However, this picture is disturbed when major crossings take place between the inclination-only dependent resonance considered and one of the two resonances $\Omega-\Omega_L$ and $2\Omega- \Omega_L$ that contain the precession of the lunar node. As these two resonances sweep the phase space (for increasing values of $a$) they cause large chaotic domains where our analytical estimates are no longer applicable. In these domains instead the secular evolution is governed by manifold dynamics. This is the dynamics of the stable and unstable manifolds emanating from the center manifold of circular orbits ($e=0$). In fact, the latter locally satisfies the properties of a normally hyperbolic invariant manifold (NHIM). Applications to the problem of EoL disposal are finally discussed.https://cassyni-user-files-prod.s3.amazonaws.com/6qQa5DJoNWbJGNXUN44irz https://cassyni.com/slides/outline/KyPje8tTyqMshwgLrAA7M7 https://cassyni.com/events/KyPje8tTyqMshwgLrAA7M7/abstract https://cassyni-user-files-prod.s3.amazonaws.com/W3SFkraekk89fdHFQGifJv https://cassyni.com/events/KyPje8tTyqMshwgLrAA7M7?videoPreview=1 The Philippine Biomedical Devices Engineering Research and Its Current Status: A DLSU-IBEHT Perspective AND Intellectual Property as a Tool for Technology Commercializationnohttps://cassyni.com/events/KyPje8tTyqMshwgLrAA7M7?videoPreview=12023-10-31T03:00:00+00:003379.4The Auckland Bioengineering InstituteThis presentation has two-parts. In the first half the Director of IBEHT will discuss the Biomedical Devices Ecosystem in the Philippines. It will also explore a general view on how the field of biomedical engineering evolved in the Philippines, the initiatives and efforts that have been made for it to continue evolving, as well as the factors hindering its advancement. The author will also present the initiatives on biomedical devices innovation and health technologies from different research institutions. The role played by the National Unified Health Research Agenda (NUHRA) will be discussed as it sets the overall direction of research thrust and other initiatives relating to healthcare done by the public and private sectors in the Philippines. Additionally, it will also the efforts of the Philippines through the Department of Science and Technology (DOST) in responding to the COVID-19 Pandemic. In conclusion, the author will present the De La Salle University – Institute of Biomedical Engineering and Health Technologies (DLSU-BEHT), a one-stop-shop for information and support infrastructure on biomedical devices innovation and health technologies research in the Philippines and the current research projects will be highlighted. In the second part of the talk the University legal counsel will present 'Intellectual Property as a Tool for Technology Commercialization', from the perspective of the Intellectual Property Office, and Innovation and Technology Office.https://cassyni-user-files-prod.s3.amazonaws.com/W3SFkraekk89fdHFQGifJv https://cassyni.com/slides/outline/RuEERbgY43rsUWiGrZM9Pb https://cassyni.com/events/RuEERbgY43rsUWiGrZM9Pb/abstract https://cassyni-user-files-prod.s3.amazonaws.com/K4u1CG9TmpmJKWhXeCo5en https://cassyni.com/events/RuEERbgY43rsUWiGrZM9Pb?videoPreview=1 The Impact of Medicare Annual Wellness Visit Education on Advance Care Planning in a Family Medicine Residency Training Programnohttps://cassyni.com/events/RuEERbgY43rsUWiGrZM9Pb?videoPreview=12024-02-08T21:00:00+00:002781.12Family MedicineLearning Objectives: - Understand the Significance of Annual Wellness Visits (AWVs) in ACP: - Evaluate the Impact of Resident Education on ACP Documentation - Consider implications of AWV education on patient centered care and future practiceshttps://cassyni-user-files-prod.s3.amazonaws.com/K4u1CG9TmpmJKWhXeCo5en https://cassyni.com/slides/outline/WM1RcVUVCSzJESyUsG712d https://cassyni.com/events/WM1RcVUVCSzJESyUsG712d/abstract https://cassyni-user-files-prod.s3.amazonaws.com/XeGfH5rKoAP9SoRPzBRdYA https://cassyni.com/events/WM1RcVUVCSzJESyUsG712d?videoPreview=1 Granular flows in reduced gravity environmentsnohttps://cassyni.com/events/WM1RcVUVCSzJESyUsG712d?videoPreview=12022-01-14T12:00:00+00:004772.12Granular MatterAsteroids, moons, and planetesimals exhibit surprising shapes and patterns that appear to be formed through granular interactions at low gravity. For example, in the absence of wind or other external influences, the small asteroid Itokawa (gravity ~ 10^-5 g) has somehow separated fine sand from large boulders, and the larger asteroid Eros (10^-3 g) has concentrated ponds of apparently pure sand through mechanisms that are not understood. At slightly larger scales, Saturn’s sandy moons Pan and Atlas have developed striking ravioli shapes, while rocky debris on the moon Iapetus (10^-2 g) has formed a 20 km high equatorial ridge. In this talk, we describe both common and unique granular behaviors that play an important role in morphogenesis and that arise predominantly at reduced gravity.https://cassyni-user-files-prod.s3.amazonaws.com/XeGfH5rKoAP9SoRPzBRdYA https://cassyni.com/events/69EpLzmmh1rQ4mDdwUohcH/abstract https://cassyni-user-files-prod.s3.amazonaws.com/4Hmb8d7JGQXWQCCLcSJGd4 https://cassyni.com/slides/outline/8cUqaR1PtJctRhhCVAiLLD https://cassyni.com/events/8cUqaR1PtJctRhhCVAiLLD/abstract https://cassyni-user-files-prod.s3.amazonaws.com/CPckW1no6q3b3avBLaievJ https://cassyni.com/events/8cUqaR1PtJctRhhCVAiLLD?videoPreview=1 Camera Fingerprinting and its Applicationsnohttps://cassyni.com/events/8cUqaR1PtJctRhhCVAiLLD?videoPreview=12021-07-01T12:30:00+00:003639.12Journal on Image and Video ProcessingNo abstracthttps://cassyni-user-files-prod.s3.amazonaws.com/CPckW1no6q3b3avBLaievJ https://cassyni.com/slides/outline/G2CuGfiGUAvivHDfT3a4kD https://cassyni.com/events/G2CuGfiGUAvivHDfT3a4kD/abstract https://cassyni-user-files-prod.s3.amazonaws.com/A67F7yQsdJFYUuQtKD5NbQ https://cassyni.com/events/G2CuGfiGUAvivHDfT3a4kD?videoPreview=1 Hollow fiber or flat sheet membranes and modules - Does it matter?nohttps://cassyni.com/events/G2CuGfiGUAvivHDfT3a4kD?videoPreview=12024-02-20T13:00:00+00:003997.88ElsevierMembrane separation processes are the preferred option for diverse commercial separations. This preference arises primarily from a reduction in separation costs due to reduced energy costs. The most common geometries for high-performance membranes are flat sheets and hollow fibers. Compact separation devices (i.e., modules) are fabricated from the membrane to facilitate fluid introduction and removal at the scale required industrially. Both hollow fiber and flat sheet membrane modules are available commercially. A common question asked by those developing new membrane materials is which geometry is preferable. The factors that influence this choice are discussed with emphasis on considerations for liquid separations. A review of the patent literature on membrane and module fabrication is presented [1] along with inherent manufacturing and performance limitations reported in the literature for both membrane geometries [2]. The trade-offs between the two geometries are explored to help future innovators evaluate the risks in geometry selection.https://cassyni-user-files-prod.s3.amazonaws.com/A67F7yQsdJFYUuQtKD5NbQ https://cassyni.com/slides/outline/B5iroqF25bPhXBWKSZs525 https://cassyni.com/events/B5iroqF25bPhXBWKSZs525/abstract https://cassyni-user-files-prod.s3.amazonaws.com/2eSSguDjRhYFArjNezkuMY https://cassyni.com/events/B5iroqF25bPhXBWKSZs525?videoPreview=1 Autonomous muscle-driven motion - spine biomechanics, motor control and forensic neuromechanicsnohttps://cassyni.com/events/B5iroqF25bPhXBWKSZs525?videoPreview=12023-11-07T03:00:00+00:003077.2The Auckland Bioengineering InstituteBiological motion is fascinating. Especially locomotion plays a crucial part in the evolution of life. Highly evolved structures, like bones connected by joints and soft tissues and contracting proteins in a muscle-tendon unit, enable and prescribe the respective species' specific locomotion pattern. Most importantly, biological motion is autonomously learned, it is untethered as there is no external energy supply and typical for vertebrates, it's muscle-driven. We approach this facinating topic from a modelling and simulation perspective. This talk will give three recent examples of our work in the following fields: spine biomechanics, motor control, forensic neuromechanicshttps://cassyni-user-files-prod.s3.amazonaws.com/2eSSguDjRhYFArjNezkuMY https://cassyni.com/events/UNUFf1vAFLdMqTBqQFFn7X/seminar/qa https://cassyni.com/slides/outline/UNUFf1vAFLdMqTBqQFFn7X https://cassyni.com/events/UNUFf1vAFLdMqTBqQFFn7X/abstract https://cassyni-user-files-prod.s3.amazonaws.com/VRaKbt2ghuNNAXZjYuf64n https://cassyni.com/events/UNUFf1vAFLdMqTBqQFFn7X?videoPreview=1 Elastic wave propagation in cubic non-centrosymmetric and chiral architectured materials: insights from strain gradient elasticitynohttps://cassyni.com/events/UNUFf1vAFLdMqTBqQFFn7X?videoPreview=12024-02-27T14:00:00+00:003662.04MetaMATThe study of elastic wave propagation is a fundamental tool in different fields, from Non-destructive Damage Evaluation (NDE) to ultrasonic imaging. Usually NDE and characterisation techniques rely on inversion methods based on homogenised theories, that are valid only when the wavelength of the perturbation is considerably larger than the characteristic size of the heterogeneities of the materials. When the wavelength approaches this characteristic size, an upscaling occurs and mesoscopic effects can be transferred to the macro-scale. In this case, classic models used in the aforementioned inversion procedures can fail to predict the correct response [1] and they need to be improved [2]. In this work, we address those architectures for which the unit cell does not have any centre of inversion (non-centrosymmetric) nor symmetry plane (chiral). It will be shown that unconventional effects, in terms of dispersion and polarisation, can be observed even for large wavelengths. We will also prove that for describing these materials using an equivalent homogeneous continuum, the use of an enriched or generalized theory, such as strain gradient elasticity, is mandatory. Moreover, the analysis of the generalised acoustic (or Christoffel) tensor defined in this framework can give a useful insight on the dynamic features of the architectured material. Among others, the example of the gyroid unit cell will be detailed.https://cassyni-user-files-prod.s3.amazonaws.com/VRaKbt2ghuNNAXZjYuf64n https://cassyni.com/slides/outline/MTNAtpLvhZwrCAVrkEkQLD https://cassyni.com/events/MTNAtpLvhZwrCAVrkEkQLD/abstract https://cassyni-user-files-prod.s3.amazonaws.com/D98faYAyYbXTzjJyooLNaS https://cassyni.com/events/MTNAtpLvhZwrCAVrkEkQLD?videoPreview=1 Anthromes, CO2 and Terrestrial Carbon – Session 10.1 Tropical forest carbon in an unequal world: a social science perspectivenohttps://cassyni.com/events/MTNAtpLvhZwrCAVrkEkQLD?videoPreview=12023-10-06T09:30:00+00:001694.84The New Phytologist FoundationThe role of tropical forestlands in the carbon cycle is a planetary concern. As scientists use data and models to predict terrestrial carbon dynamics, decision-makers discuss whether they should rely on forests to offset emissions. Particular attention has been paid to the tropics because this is where uncertainties in the estimates are highest and carbon gains from reducing deforestation and maintaining forest cover are expected to be greatest. In Earth system science and global environmental policy circles, it is often self-evident that tropical forestlands matter primarily for the carbon sequestration of large-scale biomes. However, the political implications of this system-level view raise many questions from a social science perspective as tropical regions face the uncertain consequences of carbon quantification and related initiatives meant to address forest loss. Drawing on a literature review and interviews with natural scientists, development experts and state officials working in the Congo basin, our contribution focuses on the politics of forest carbon and its implications in this particular context, from limited statehood and aid dependency, to the phenomenon of extraverted science and lack of research autonomy. We ask whether the ‘net-zero culture’ contributes to reducing or reproducing existing inequalities in forest-rich countries and between research communities.https://cassyni-user-files-prod.s3.amazonaws.com/D98faYAyYbXTzjJyooLNaS https://cassyni.com/slides/outline/9bqHu3LDZwaroB1nV6CNeZ https://cassyni.com/events/9bqHu3LDZwaroB1nV6CNeZ/abstract https://cassyni-user-files-prod.s3.amazonaws.com/TveGv7MjDQxtEJv3S4kCE https://cassyni.com/events/9bqHu3LDZwaroB1nV6CNeZ?videoPreview=1 Patient‐reported causes of distress predict disparities in time to evaluation and time to treatment after breast cancer diagnosisnohttps://cassyni.com/events/9bqHu3LDZwaroB1nV6CNeZ?videoPreview=12024-08-15T18:00:00+00:003113.28Center for Cancer TrainingWe examined whether the National Comprehensive Cancer Network Distress Thermometer (DT) and Problem List, a patient-reported outcome measure (PROM), could be used to identify levels and causes of distress among women presenting with breast cancer. We identified women aged ≥18 years with stage 0-IV breast cancer who were diagnosed in a single health system between January 2014 and July 2016. The baseline visit was defined as the first postdiagnosis, pretreatment clinical evaluation. Regression models were used to examine associations between baseline DT score (0 = none to 10 = extreme) and types of stressors (emotional, familial, practical, physical, spiritual) after adjustment for race/ethnicity and other characteristics and to identify predictors of time to evaluation (TTE) and time to treatment (TTT). A total of 1029 women were included (median baseline DT score = 4). Emotional, physical, and practical stressors were associated with distress (all P < .05). Black patients (n = 258) were >2.5x as likely to report no distress as Whites (n = 675; OR 2.72; 95% CI, 1.68-4.40; P < .001) despite reporting a similar number of stressors. Higher DT scores were associated with shorter TTE and TTT while being Black and having physical or practical stressors were associated with delays in both (all P < .05). Having physical or practical stressors particularly exacerbated delays in TTE and TTT, for Hispanic patients, who represented only a small proportion of our cohort but had the longest delays to evaluation (23 days) and treatment (71 days) of any group and some of the highest median self-reported distress levels. Early psychosocial evaluation could potentially address delays in time to care and mitigate disparities for vulnerable patients through targeted and culturally responsive interventions for modifiable barriers to care.https://cassyni-user-files-prod.s3.amazonaws.com/TveGv7MjDQxtEJv3S4kCE https://cassyni.com/events/Hzpwa2pFdN5DAUCJ6aNSoP/abstract https://cassyni-user-files-prod.s3.amazonaws.com/LSAuDgHRaHSRcMyhE6Xj82 https://cassyni.com/events/Mx52Am2DwkMSqKwzk1hYRK/seminar/qa https://cassyni.com/slides/outline/Mx52Am2DwkMSqKwzk1hYRK https://cassyni.com/events/Mx52Am2DwkMSqKwzk1hYRK/abstract https://cassyni-user-files-prod.s3.amazonaws.com/F5dLFUMAvaJJaWkcSHbyxS https://cassyni.com/events/Mx52Am2DwkMSqKwzk1hYRK?videoPreview=1 Entrainment into a turbulent wake from a turbulent background and the turbulent/turbulent interfacenohttps://cassyni.com/events/Mx52Am2DwkMSqKwzk1hYRK?videoPreview=12024-06-04T14:00:00+00:003294.4Experiments in FluidsTurbulent flows are known to grow with downstream distance; think of a volcanic plume broadening as streamwise distance from the volcanic crater increases. This spreading occurs due to the transport, and mixing, of background fluid into the turbulent flow across the sharp interface demarcating the turbulent flow from the background in a process known as entrainment. In the special case where the background is non-turbulent this interface is known as the turbulent/non-turbulent interface and entrainment is known to be driven by viscous diffusion of the turbulent fluid into the background. This was first postulated by Corrsin and Kistler [1] and arises since the turbulent/non- turbulent interface is, in-effect, an isosurface of zero vorticity-magnitude to account for the fact that the background is irrotational whilst the vorticity is, by definition, non-zero in the turbulent portion of the flow. Accordingly the only non-zero source term at the turbulent/non-turbulent interface in the vorticity-magnitude transport equation is viscous diffusion. However, many (most) industrial and environmental flows exist within a turbulent background, for example wind-turbine wakes are exposed to atmospheric turbulence and gas-turbine blades are exposed to the turbulent outflow of the combustor. In such cases the intuition of Corrsin and Kistler [1] breaks down. Indeed, in the review paper of da Silva et al. [2] it was even suggested that when two streams of turbulence with comparable turbulence intensity are adjacent to one another the interface between them breaks down meaning that there is no discernible interface demarcating the adjacent streams of turbulence. In this seminar we prove the existence of a turbulent/turbulent interface [3] for a wake exposed to various degrees of freestream turbulence, including cases where the intensity of the freestream turbulence is greater than that within the wake. We will then explore the physics of the turbulent/turbulent interface which are different than those for turbulent/non-turbulent interfaces [4]. Finally, we will then examine how the presence of freestream turbulence affects the entrainment rate into the wake, considering the spatial evolution of the entrainment of mass, streamwise momentum, and kinetic energy [5]. Understanding these physics is important to being able to more accurately predict the spreading of turbulent flows exposed to freestream turbulence which is important for e.g. designing layouts for more efficient future wind farms.https://cassyni-user-files-prod.s3.amazonaws.com/F5dLFUMAvaJJaWkcSHbyxS https://cassyni.com/slides/outline/LU4xoT3speqhXQfreGH5XK https://cassyni.com/events/LU4xoT3speqhXQfreGH5XK/abstract https://cassyni-user-files-prod.s3.amazonaws.com/EkEsym2RyLKq7AHKNu4p8N https://cassyni.com/events/LU4xoT3speqhXQfreGH5XK?videoPreview=1 Introducing Transformative Plant Biotechnology: Boosting photosynthesis: engineering a pyrenoid-based CO2-concentrating mechanism into plantsnohttps://cassyni.com/events/LU4xoT3speqhXQfreGH5XK?videoPreview=12023-09-21T10:30:00+00:001606.8The New Phytologist FoundationThe CO2-fixing enzyme Rubisco is considered a rate-limiting step in plant productivity due to its slow carboxylation rate and wasteful side reaction with O2. Improving the efficiency of Rubisco in crops would represent a transformative step-change in Plant Biotechnology. Green algae such as Chlamydomonas reinhardtii can concentrate CO2 around Rubisco in a structure called a pyrenoid, which significantly increases the efficiency of Rubisco carboxylation and reduces its oxygenase reaction. We aim to engineer a pyrenoid-based CO2 concentrating mechanism (pCCM) into plants to increase the performance of Rubisco and hence crop productivity and resilience. The pCCM in Chlamydomonas relies on several features to function, including the condensation of Rubisco into a phase-separated matrix, a network of thylakoid tubules that traverse the matrix, delivery of CO2 to Rubisco, and a diffusion barrier in the form of a starch sheath, which prevents escape of CO2. Previously we have engineered a pyrenoid-like Rubisco matrix in Arabidopsis. Here we show that introducing the Chlamydomonas proteins MITH1 and MITH2 allows thylakoid traversions to form across the matrix. In addition, the expression of the carbohydrate-binding proteins SAGA1 and SAGA2 leads to the recruitment of plate-like starch granules around the matrix. These findings take us a major step forward towards reconstituting a functional pCCM in plants, which when implemented in crops could help the challenge of increasing crop yields to ameliorate global food security concerns.https://cassyni-user-files-prod.s3.amazonaws.com/EkEsym2RyLKq7AHKNu4p8N https://cassyni.com/slides/outline/Tso2VhkkQX9Y1zCKc98owK https://cassyni.com/events/Tso2VhkkQX9Y1zCKc98owK/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Q4AbBFyenSQik3cUg5omsC https://cassyni.com/events/Tso2VhkkQX9Y1zCKc98owK?videoPreview=1 Biased agonism in the mu-opioid receptornohttps://cassyni.com/events/Tso2VhkkQX9Y1zCKc98owK?videoPreview=12021-09-20T12:00:00+00:003683.0Discover Applied SciencesDr. Karina Martinez-Mayorga discuss Biased agonism in the mu-opioid receptor.https://cassyni-user-files-prod.s3.amazonaws.com/Q4AbBFyenSQik3cUg5omsC https://cassyni.com/slides/outline/BaQ5y9QRvQsXLeVqEfz3CH https://cassyni.com/events/BaQ5y9QRvQsXLeVqEfz3CH/abstract https://cassyni-user-files-prod.s3.amazonaws.com/HeGa7f5UNpJxym5xPRqT34 https://cassyni.com/events/BaQ5y9QRvQsXLeVqEfz3CH?videoPreview=1 The Life and fate of a bubble in a Hele-Shaw channelnohttps://cassyni.com/events/BaQ5y9QRvQsXLeVqEfz3CH?videoPreview=12020-06-30T14:00:00+00:003789.68Leeds Institute for Fluid DynamicsMotivated by a desire to understand complex transient behaviour in fluid flows, we study the propagation of an air bubble through a fluid-filled, geometrically-perturbed Hele-Shaw channel; a system which supports several stable modes of bubble propagation. Using experiments and numerical simulations of a depth-averaged lubrication model, we investigate the evolution of a centred bubble of fixed volume as a function of flow rate and initial shape. During its transient evolution, a bubble may undergo several topological changes in the form of breakup and coalescence, depending on parameter values. Long-term, either a single bubble is recovered or else multiple bubbles remain, whose relative separation increases with time. Despite its apparent complexity the bubbles’ transient behaviour is organised by a number of weakly unstable invariant solutions of the system, so-called edge states. An unusual feature of the system is that changes in topology due to bubble break-up or coalescence lead to changes in the invariant-solution structure during temporal evolution. Families of two-bubble and single-bubble invariant solutions can be related in the sense that their propagation speeds are identical, but there are also two-bubble solutions that do not have single-bubble equivalents. We explore how the bubble becomes increasingly sensitive to initial conditions and roughness of the channel as the flow rate increases with a view to establish the origin of the long and disordered transients observed.https://cassyni-user-files-prod.s3.amazonaws.com/HeGa7f5UNpJxym5xPRqT34 https://cassyni.com/events/Jz9mn2dBue75yhihV7nDEu/abstract https://cassyni-user-files-prod.s3.amazonaws.com/DxXSqiLVCKDiP3GNACmQBp https://cassyni.com/slides/outline/KUpzwLnbkTauoAiDHDuBR7 https://cassyni.com/events/KUpzwLnbkTauoAiDHDuBR7/abstract https://cassyni-user-files-prod.s3.amazonaws.com/MjLuCpkXn7XKCXWz7U2HzW https://cassyni.com/events/KUpzwLnbkTauoAiDHDuBR7?videoPreview=1 Creating digital twins of the shoulder complex to improve pre-operative planning of joint replacement surgerynohttps://cassyni.com/events/KUpzwLnbkTauoAiDHDuBR7?videoPreview=12024-07-03T00:00:00+00:003239.56Auckland Bioengineering InstituteComputational models of the musculoskeletal system, coupled with wearable sensors for real-time feedback (i.e. the Digital Twin) have tremendous clinical application in the field of orthopaedics and joint replacement, which currently relies upon the skill and experience of a surgeon to achieve a good outcome. This is particularly true for shoulder arthroplasty (glenohumeral joint replacement), as the shoulder has a large range of motion that is stabilised and controlled by coordinated activation of many muscles crossing the joint. A computational model that represents the anatomy of the patient, can simulate the motion and forces of the joint and then predict clinical outcomes for varying implant designs and placements would provide orthopaedic surgeons with the necessary tools to plan surgeries and achieve better outcomes. However, several challenges need to be addressed before bringing the Digital Twin into clinical practice: 1. Creating models of the complex anatomy (bones, muscles, joints, ligaments etc) is time-consuming and required 3D medical imaging 2. Measuring and characterising movement of the shoulder is challenging, as the shoulder moves across the rib cage and lies underneath soft tissue 3. Bone is a living tissue, and responds to its surrounding mechanical environment, so predicting how an implant might perform in a patient requires some understanding and prediction of bone adaptation and remodelling processes. We propose a paradigm shift towards personalised medicine for shoulder arthroplasty by developing methods to rapidly generate a Digital Twin of the shoulder, updating this model with wearable sensor technology to measure and characterise motion and computational approaches to bone remodelling. This talk will present some of the approaches and validation studies that have been completed thus far to address the challenges above. The methods and models developed within this work aim to provide the clinician with quantitative information in the shoulder arthroplasty surgery planning phase and ultimately improve long-term outcomes for patients. *The audio in this video begins at approximately 02:15.* https://cassyni-user-files-prod.s3.amazonaws.com/MjLuCpkXn7XKCXWz7U2HzW https://cassyni.com/slides/outline/VMmTkPDD8FjWWD1qWDj6vR https://cassyni.com/events/VMmTkPDD8FjWWD1qWDj6vR/abstract https://cassyni-user-files-prod.s3.amazonaws.com/JknHygBHbrznzq2Soyes4a https://cassyni.com/events/VMmTkPDD8FjWWD1qWDj6vR?videoPreview=1 Plume dispersion in non-neutrally-stratified boundary layersnohttps://cassyni.com/events/VMmTkPDD8FjWWD1qWDj6vR?videoPreview=12023-02-10T12:00:00+00:002864.96UK Fluids NetworkNon-neutral stratification can have an important role in mixing and dispersing pollutant plumes, but systematic experiments are rare, despite the fact that stable or convective atmospheric conditions often represent the majority of cases in actual urban flows. The EnFlo wind tunnel at the University of Surrey is one of the very few facilities capable of simulating these atmospheric flows. In this presentation I’m going to show some of the recent results from the experimental work at EnFlo, with particular focus on flow and dispersion in urban areas. Experiments ranged from fundamental studies in plume dispersion in non-neutral boundary layers to applied research in urban fluid mechanics with and without local heat sources.https://cassyni-user-files-prod.s3.amazonaws.com/JknHygBHbrznzq2Soyes4a https://cassyni.com/events/5eg5eCfuTe5S9zFWNYYmgH/abstract https://cassyni-user-files-prod.s3.amazonaws.com/J878DQW6nHVnz39YjHt374 https://cassyni.com/slides/outline/59zrUtWVcpbcLXFzaSRoW5 https://cassyni.com/events/59zrUtWVcpbcLXFzaSRoW5/abstract https://cassyni-user-files-prod.s3.amazonaws.com/8P16vVAhsdANyHCi64Vr6i https://cassyni.com/events/59zrUtWVcpbcLXFzaSRoW5?videoPreview=1 Donor Clonal Hematopoiesis and Recipient Outcomes After Transplantationnohttps://cassyni.com/events/59zrUtWVcpbcLXFzaSRoW5?videoPreview=12023-02-16T14:00:00+00:003445.04Center for Cancer TrainingClonal hematopoiesis (CH) can be transmitted from a donor to a recipient during allogeneic hematopoietic cell transplantation. Exclusion of candidate donors with CH is controversial since its impact on recipient outcomes and graft alloimmune function is uncertain. We performed targeted error-corrected sequencing on samples from 1,727 donors age 40 years or older and assessed the effect of donor CH on recipient clinical outcomes. We measured long-term engraftment of 102 donor clones and cytokine levels in 256 recipients at 3 and 12 months after transplant. We found that donor CH is closely associated with clinical outcomes in transplant recipients, with differential impact on graft alloimmune function and potential for leukemic transformation related to mutated gene and somatic clonal abundance. Donor DNMT3A-CH is associated with improved recipient survival because of reduced relapse risk and with an augmented network of inflammatory cytokines in recipients. Risk of donor cell leukemia in allogeneic hematopoietic cell transplantation is driven by somatic myelodysplastic syndrome–associated mutations or germline predisposition in donors.https://cassyni-user-files-prod.s3.amazonaws.com/8P16vVAhsdANyHCi64Vr6i https://cassyni.com/slides/outline/EYKLMsoTxX7tCGj8VZuNNh https://cassyni.com/events/EYKLMsoTxX7tCGj8VZuNNh/abstract https://cassyni-user-files-prod.s3.amazonaws.com/G4yq9Mid8XjJ8eQuHDgre2 https://cassyni.com/events/EYKLMsoTxX7tCGj8VZuNNh?videoPreview=1 Orthogonal polynomials. Fourier series in orthogonal polynomials. Trace formula and asymptotics of Forsythe determinant.nohttps://cassyni.com/events/EYKLMsoTxX7tCGj8VZuNNh?videoPreview=12023-12-14T15:00:00+00:003380.56Journal of Mathematical SciencesThe following issues will be outlined: 1. Systems of polynomials {𝑝𝑛(𝑥)}(n∈ℤ+) orthogonal to a measure and systems of Sobolev polynomials {𝑞𝑛(𝑥)}(n ∈ ℤ+). 2. Fourier series on systems and {𝑝𝑛(𝑥)} and {𝑞𝑛(𝑥)}. 3. Trace formula and asymptotics of the Forsythe determinant.https://cassyni-user-files-prod.s3.amazonaws.com/G4yq9Mid8XjJ8eQuHDgre2 https://cassyni.com/events/2C8rKR9EPSCo8HwwitAp9T/abstract https://cassyni-user-files-prod.s3.amazonaws.com/JVgCLonQKTh3gSPyC2YFpz https://cassyni.com/slides/outline/SPuTauqwtsLhHyhnefU7Zo https://cassyni.com/events/SPuTauqwtsLhHyhnefU7Zo/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Y2shxYzNmwtieMMHWfen9t https://cassyni.com/events/SPuTauqwtsLhHyhnefU7Zo?videoPreview=1 Rates of cylindrical and spherical copper anodes dissolving into concentrated NaCl water solution calculation during electrolysis and temperature increasingnohttps://cassyni.com/events/SPuTauqwtsLhHyhnefU7Zo?videoPreview=12024-03-10T12:00:00+00:001819.6International Journal of Thermofluids Our experimental investigations show that rate of copper anodes degradation decreases during electrolysis in concentrated NaCl solution in water (5 mol/kg or 23 %, freezing point equals −22°C, pH 6.5–7.5) at electric current density about 3000 A/m2 (or 30 A/dm2 = 3 mA/mm2) with temperature increasing from room temperature to 100 °C. Electric current value also increases with temperature increasing. Really, such result is unexpected. General quantity of the H+ and Cl− ions decreases during electrolysis at all temperatures since the H2 and Cl2 gases are formed near electrodes. General quantity of the Cu+ and Cu2+ ions decreases with temperature increasing too. We guess that one reason only should be for electric current value increasing: average charge of copper ions increases from +1 at room temperature to +1.5 at 100 °C and to +2 at 180°C. Corresponding mathematical model is proposed for the analysis. Literature experimental data are used too.https://cassyni-user-files-prod.s3.amazonaws.com/Y2shxYzNmwtieMMHWfen9t https://cassyni.com/slides/outline/StZ4dbVULKtkHkEgF6kuq7 https://cassyni.com/events/StZ4dbVULKtkHkEgF6kuq7/abstract https://cassyni-user-files-prod.s3.amazonaws.com/JdFwKRRaUEiyJz7BiKhWY6 https://cassyni.com/events/StZ4dbVULKtkHkEgF6kuq7?videoPreview=1 Dialysis Refusal: Hot and Cold Decision-makingnohttps://cassyni.com/events/StZ4dbVULKtkHkEgF6kuq7?videoPreview=12022-11-02T15:00:00+00:002204.08Imperial College Renal and Transplant CentreNo abstracthttps://cassyni-user-files-prod.s3.amazonaws.com/JdFwKRRaUEiyJz7BiKhWY6 https://cassyni.com/events/C56wF65jAbH7yowyESwBHP/abstract https://cassyni-user-files-prod.s3.amazonaws.com/EWkhaQB22ANmddajPvDJUn https://cassyni.com/slides/outline/NTCDA9RpELetz8W69NEFUH https://cassyni.com/events/NTCDA9RpELetz8W69NEFUH/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Uwjqv1Fi488fXk8eayELmL https://cassyni.com/events/NTCDA9RpELetz8W69NEFUH?videoPreview=1 Olsson.wl & ROC2.wl: Mathematica packages for transformations of multivariable hypergeometric functions & regions of convergence for their series representations in the two variables casenohttps://cassyni.com/events/NTCDA9RpELetz8W69NEFUH?videoPreview=12024-05-20T12:00:00+00:001811.16Computer Physics CommunicationsWe present the Olsson.wl Mathematica package which aims to find transformations for some classes of multivariable hypergeometric functions. It is based on a well-known method developed by P. O. M. Olsson in J. Math. Phys. 5, 420 (1964) to derive the analytic continuations of the Appell $F_1$ double hypergeometric series using the linear transformations of the Gauss $_2F_1$ hypergeometric function. We provide a brief description of the method of Olsson and demonstrate the use of the commands of the Olsson.wl package using some examples. In particular, we reproduce various results of the literature on multivariable hypergeometric functions and show practical applications of this package in the derivation of novel formulas. In the context of high energy physics, we also demonstrate how it can be used to disentangle some known results about the analytic continuation of some series representations of the one-loop pentagon in multi-Regge kinematics and $D=6-2\epsilon$. We also present companion package, called ROC2.wl, which is dedicated to the derivation of the regions of convergence of double hypergeometric series. This package can be used independently of Olsson.wl.https://cassyni-user-files-prod.s3.amazonaws.com/Uwjqv1Fi488fXk8eayELmL https://cassyni.com/events/NwqpCq5LfoCwyu2yjoX3jb/seminar/qa https://cassyni.com/slides/outline/NwqpCq5LfoCwyu2yjoX3jb https://cassyni.com/events/NwqpCq5LfoCwyu2yjoX3jb/abstract https://cassyni-user-files-prod.s3.amazonaws.com/TxCrxFk3C4e7HMk5LvzTwc https://cassyni.com/events/NwqpCq5LfoCwyu2yjoX3jb?videoPreview=1 Who Cares for Black Women in Health and Health Carenohttps://cassyni.com/events/NwqpCq5LfoCwyu2yjoX3jb?videoPreview=12024-08-28T14:00:00+00:003572.84Women's HealthBlack women are often at the center of health disparities research. Black women face sociological, psychological, environmental, and political barriers to health and health care that leave them in a persistent cycle of poor health outcomes. Black women are more likely to (1) face racism, sexism, and other forms of discrimination which are linked to stress and other mental health concerns; (2) head households both financially and in terms of care; and (3) receive lower quality healthcare. Much health disparities research calls for a more inclusive and representative health care field. Evidence in support of recruiting, retaining, and centering Black women in health and healthcare is abundant. This call for representation ranges from medical professionals to individuals engaged in research on health and healthcare. What is less central to conversations around health disparities and representation, is burnout. Specifically, who cares for the Black women who serve others? How do they manage the worries of healthcare and related disparities, while also facing the same daily stressors that put Black women’s health at risk. As scholars engage in work aimed toward diversifying STEM, hospitals, and the academy, it is vital to also grapple with the costs of this push for representation. Grappling with the costs provides an opportunity to develop trainings, recruiting strategies, and retention plans that allow Black women in health and healthcare to thrive. The collection of articles in this special collection aims to provide a platform to amplify work on the Black women who work to decrease health disparities while also navigating structural inequalities themselves.https://cassyni-user-files-prod.s3.amazonaws.com/TxCrxFk3C4e7HMk5LvzTwc https://cassyni.com/slides/outline/HWiAhJxZqm7sb2nk8tXFk9 https://cassyni.com/events/HWiAhJxZqm7sb2nk8tXFk9/abstract https://cassyni-user-files-prod.s3.amazonaws.com/EGBMhcvKdvikP4F6ArM5zN https://cassyni.com/events/HWiAhJxZqm7sb2nk8tXFk9?videoPreview=1 Transport and Settling of Microplastics in Turbidity Currentsnohttps://cassyni.com/events/HWiAhJxZqm7sb2nk8tXFk9?videoPreview=12024-04-04T14:00:00+00:003287.44The Edinburgh Fluid Dynamics Group (EFDG)Although tens of millions of tons of plastic waste are released into the ocean each year, less than 300 kilotons remain on or near the ocean surface.  This is particularly puzzling because more than half of plastics that are produced are buoyant in sea water.   One mechanism that can result in buoyant plastic settling is the process of biofouling in which microbes and other organic material can accumulate on the plastics rendering them more dense.   Less studied is the accumulation of inorganic material on the plastics.  For example, clay has recently been shown to attach to plastics, particularly in the presence of surfactants.   Here we report on laboratory experiments showing that plastic particles which are less dense than fresh water can settle due to the accumulation of glass spheres ("sand") on their surface.  This process is shown to occur dynamically as sand and plastic particles mix turbulently during the impulsive release of a turbidity current, which can carry some of the plastic particles to depth along with the settling sand. [This work reports on experiments performed by Woods Hole Oceanographic Institute (WHOI) Geophysical Fluid Dynamics (GFD) Fellow Quentin Kriaa during the WHOI GFD Summer Program 2023, co-supervised by Claudia Cenedese and Jim McElwaine.] https://cassyni-user-files-prod.s3.amazonaws.com/EGBMhcvKdvikP4F6ArM5zN https://cassyni.com/events/VrvGrQ8gpCxjUi2Z7F5ytH/seminar/qa https://cassyni.com/slides/outline/VrvGrQ8gpCxjUi2Z7F5ytH https://cassyni.com/events/VrvGrQ8gpCxjUi2Z7F5ytH/abstract https://cassyni-user-files-prod.s3.amazonaws.com/5ft6uhVogx2mrJejwtZ7g2 https://cassyni.com/events/VrvGrQ8gpCxjUi2Z7F5ytH?videoPreview=1 Quantum algorithm for smoothed particle hydrodynamicsnohttps://cassyni.com/events/VrvGrQ8gpCxjUi2Z7F5ytH?videoPreview=12024-06-17T13:00:00+00:001467.2Computer Physics CommunicationsIn this talk, I present a quantum algorithm for the smoothed particle hydrodynamics (SPH) method. Despite significant progress in speeding up the SPH algorithm with parallelisation schemes and graphics processing units, it remains a computationally intensive algorithm for real-world engineering problems. To address these issues, our paper provides a proof-of-concept for a quantum SPH (QSPH) algorithm. This talk outlines how the QSPH algorithm can solve the 1D advection and diffusion equations. This is achieved by performing the computationally expensive parts of the SPH calculation on a quantum computer. I also discuss the work required to improve the algorithm before it can efficiently simulate complex engineering problems on gate-based quantum computers. DOI: 10.1016/j.cpc.2023.108909https://cassyni-user-files-prod.s3.amazonaws.com/5ft6uhVogx2mrJejwtZ7g2 https://cassyni.com/slides/outline/QvSEPZfSRdRi5cKD6mNzA9 https://cassyni.com/events/QvSEPZfSRdRi5cKD6mNzA9/abstract https://cassyni-user-files-prod.s3.amazonaws.com/YGKgRb1ut9JRyspc75avN2 https://cassyni.com/events/QvSEPZfSRdRi5cKD6mNzA9?videoPreview=1 One fish, two fishnohttps://cassyni.com/events/QvSEPZfSRdRi5cKD6mNzA9?videoPreview=12021-05-28T14:00:00+00:003790.84AI Institute in Dynamic SystemsI will tell two short stories of fish hydrodynamics. In the first, I will argue, based on biological observations and mathematical models, that fish that actively flap their tail in concert with passive hydrodynamic forces can simultaneously improve their swimming speed and efficiency. In the second, I will show that flow interactions between pairs of flapping swimmers passively stabilize the pair into a cohesive formation. These stable formations occur at relative positions that favor matching the tailbeat of the follower to the local vorticity of the leader, and result in significant energy savings (up to 35% energy reduction) for the follower. Our work opens up the prospect of establishing physics-based explanations and interpretable strategies of how fish, single or in a school, can control their body motion for maximal hydrodynamic benefits.https://cassyni-user-files-prod.s3.amazonaws.com/YGKgRb1ut9JRyspc75avN2 https://cassyni.com/events/TPgFcyu4cvCCSYnmeTHct5/abstract https://cassyni-user-files-prod.s3.amazonaws.com/MmtbSjFCfKJGfhGpGka8d4 https://cassyni.com/slides/outline/2hG3JoYpg2WFH6W38EhXCR https://cassyni.com/events/2hG3JoYpg2WFH6W38EhXCR/abstract https://cassyni-user-files-prod.s3.amazonaws.com/8AYLinkGWLu3aDKhuDga3p https://cassyni.com/events/2hG3JoYpg2WFH6W38EhXCR?videoPreview=1 Documenting the first evidence for pyritized sea scorpion musclesnohttps://cassyni.com/events/2hG3JoYpg2WFH6W38EhXCR?videoPreview=12024-06-13T13:00:00+00:00564.72Royal Society PublishingPyritization of soft tissues of invertebrates is rare in the fossil record. In New York State, it occurs in black shales of the Lorraine Group (Late Ordovician), the best-known example of which is Beecher’s Trilobite Bed. Exceptional preservation at the quarry where this bed is exposed allowed detailed examination of trilobite and ostracod soft-tissue anatomy. Here, we present the first example of a eurypterid (sea scorpion) currently ascribed to Carcinosomatidae from this deposit that also preserves the first evidence for mesosomal musculature in eurypterids. This specimen demonstrates that eurypterid musculature can be preserved in pyrite and evidences the oldest example of euchelicerate muscles within the fossil record. Sulfur isotope data illustrate that pyrite rapidly replicated muscle tissue in the early burial environment, prior to the pyritization of biomineralised exoskeleton and cuticular trilobite limbs. This discovery therefore expands the limited fossil record of euchelicerate musculature, while extending the taphonomic scope for preservation of detailed internal structures, more broadly, within arthropods.https://cassyni-user-files-prod.s3.amazonaws.com/8AYLinkGWLu3aDKhuDga3p https://cassyni.com/slides/outline/3BueMVCM7V4JGs2vifzKTj https://cassyni.com/events/3BueMVCM7V4JGs2vifzKTj/abstract https://cassyni-user-files-prod.s3.amazonaws.com/3fDX7rgs5nL1rcAdXkaUHU https://cassyni.com/events/3BueMVCM7V4JGs2vifzKTj?videoPreview=1 Deep Learning of Dynamics and Coordinates with SINDy Autoencodersnohttps://cassyni.com/events/3BueMVCM7V4JGs2vifzKTj?videoPreview=12020-07-04T14:00:00+00:001470.52Brunton LabThis video by Kathleen Champion describes a new approach for simultaneously discovering models and an effective coordinate system using a custom SINDy autoencoder.https://cassyni-user-files-prod.s3.amazonaws.com/3fDX7rgs5nL1rcAdXkaUHU https://cassyni.com/events/PSX3N9EkWcgmoN2VXue1uo/seminar/qa https://cassyni.com/slides/outline/PSX3N9EkWcgmoN2VXue1uo https://cassyni.com/events/PSX3N9EkWcgmoN2VXue1uo/abstract https://cassyni-user-files-prod.s3.amazonaws.com/UKoq1AXouz5dSxsp8kgmj4 https://cassyni.com/events/PSX3N9EkWcgmoN2VXue1uo?videoPreview=1 Free Social Science: Definitionsnohttps://cassyni.com/events/PSX3N9EkWcgmoN2VXue1uo?videoPreview=12024-06-09T16:15:00+00:006202.2Cassyni SeminarsNicholas Brigham Adams, PhD (Sociology & Data Science, UC Berkeley, 2015), founder of R&D company for fighting misinformation, will discuss Independent Social Science with Oksana Stanevich from the Briva Universita and seminar guests - is it actually possible today? Topics include: - How to avoid and prevent becoming biased, - How they secure funding for sociological research, - How to combat misinformation in today's geopolitical climate, and what tools Nicholas Brigham Adams's with his team can offer for this, - What Decentralized Science means for sociology and why sociologists are now focusing on advanced technologies for the liberalization of science. The link will be sent to you via email after registration. Register via the link: https://form.jotform.com/241572150679460https://cassyni-user-files-prod.s3.amazonaws.com/UKoq1AXouz5dSxsp8kgmj4 https://cassyni.com/events/CaE8EUVKTBaa8cW4doTtLM/abstract https://cassyni-user-files-prod.s3.amazonaws.com/AJKpBz3cN9QXUpE3mSUeva https://cassyni.com/slides/outline/LyH28j18KKvHSRYvzDjPBs https://cassyni.com/events/LyH28j18KKvHSRYvzDjPBs/abstract https://cassyni-user-files-prod.s3.amazonaws.com/VSSyjUNCNdrGbseRavNLFG https://cassyni.com/events/LyH28j18KKvHSRYvzDjPBs?videoPreview=1 From the stars to your table - plants as complex conduits for iron nutritionnohttps://cassyni.com/events/LyH28j18KKvHSRYvzDjPBs?videoPreview=12024-06-08T13:00:00+00:001957.12New Phytologist Foundation Iron is a ubiquitous micronutrient that plays critical roles in central metabolic processes for all living organisms. The mechanisms by which plants extract iron from soil and maintain iron homeostasis are particularly intriguing. While it is relatively abundant, in most soils iron is insoluble and therefore of limited bioavailability, however excess iron accumulation in plants can lead to cellular damage. Thus, plants must extract sufficient quantities of iron from recalcitrant soil environments, while also ensuring that iron content does not exceed a specific range. Arabidopsis and other dicots have evolved mechanisms to sense iron deficiency in the shoot, which triggers roots to solubilize, reduce and uptake iron across multiple root cell types before transport to the shoot. Using a combination of molecular and confocal microscopy analysis, cell-type specific transcriptional profiling, and mathematical modeling we have uncovered several molecular mechanisms that control how plants recognize and respond to iron deficiency stress in a root cell-specific manner. Our findings provide new evidence for how distinct alternations in the root cortex control carbon metabolism in response to iron deprivation, and how iron deficiency causes specific developmental alterations in the root vasculature and epidermis. Together, these mechanisms operate to fine-tune root growth and physiology in the face of suboptimal growth conditions, while also providing new avenues for exploring inter- and intracellular nutrient stress response in plants.https://cassyni-user-files-prod.s3.amazonaws.com/VSSyjUNCNdrGbseRavNLFG https://cassyni.com/events/WMbW1iJ6f2SZJB24uMCx4V/seminar/qa https://cassyni.com/slides/outline/WMbW1iJ6f2SZJB24uMCx4V https://cassyni.com/events/WMbW1iJ6f2SZJB24uMCx4V/abstract https://cassyni-user-files-prod.s3.amazonaws.com/B1LdPcj4Bbu1BWKbFi851g https://cassyni.com/events/WMbW1iJ6f2SZJB24uMCx4V?videoPreview=1 Age-Friendly Health Systemsnohttps://cassyni.com/events/WMbW1iJ6f2SZJB24uMCx4V?videoPreview=12024-07-24T17:00:00+00:003141.84Sage PublishingThe Age-Friendly Health Systems movement is one of the largest efforts to improve care delivery for older adults, with thousands of health care systems recognized as “Age-Friendly.” However, significant questions regarding this movement remain, including how best to implement evidence-based practices and the effect of Age-Friendly transformation on the outcomes of older adults. This Special Collection will focus on issues of implementation and intervention effectiveness of Age-Friendly Health System redesign efforts, furthering the field.https://cassyni-user-files-prod.s3.amazonaws.com/B1LdPcj4Bbu1BWKbFi851g https://cassyni.com/events/DLrHP88m1mdjPYsy6Cev1/abstract https://cassyni-user-files-prod.s3.amazonaws.com/UMDQTEkRHD6wAV4byGrDwU https://cassyni.com/events/3gasWoMkxJY86L2SWn7Hdw/seminar/qa https://cassyni.com/slides/outline/3gasWoMkxJY86L2SWn7Hdw https://cassyni.com/events/3gasWoMkxJY86L2SWn7Hdw/abstract https://cassyni-user-files-prod.s3.amazonaws.com/6qKhjKm9ARp7piFPHUHu3k https://cassyni.com/events/3gasWoMkxJY86L2SWn7Hdw?videoPreview=1 Visual quality assessment for decision making in standardization projectsnohttps://cassyni.com/events/3gasWoMkxJY86L2SWn7Hdw?videoPreview=12024-09-05T12:00:00+00:003200.04Journal on Image and Video ProcessingIn the context of the development of compression standards for visual media, typically, most decision making relies on the measurement with one or more objective quality metrics. In many cases, a small number of very simple metrics, such as the PSNR or the SSIM, are applied in decision making processes, e.g., in the context of adoption of coding tools in to a draft specification. THis applies to a variety of visual media under consideration, such as classical 2D video or various representations of immersive visual media like dynamic point clouds or meshes. Given the rise of learning-based coding tools and -apparently- competitive end-to-end learned coding schemes, as well as the increasing number of filtering blocks inside or outside of the coding loop of conventional coding schemes, the suitability of such metrics may be questioned. This is due to a potential lack of correlation with mean opinion scores acquired by subjective assessment, especially if specific artifacts, such as temporal consistency, are not well reflected by the metric. This problem can be even more significant for more advanced, potentially learning-based metrics, which may show unexpected behavior if being applied to compression artifacts which have not been known or seen by the time of training the corresponding metric. Advisory Group ISO/IEC SC 29/AG 5 MPEG Visual Quality Assessment is tasked with evaluating and recommending metrics and testing procedures for the use in standardization projects inside the body of MPEG Working Groups developing compression standards for visual media. This webinar presents recent insights in the performance of metrics and subjective assessment methods for a variety of visual media types. The evaluation includes laboratory tests as well as remote and on-site expert viewing sessions which are frequently conducted during MPEG standardization meetings. The results and the performance of such subjective tests are assessed and used to benchmark objective metrics commonly used or considered for application in the development process. Furthermore and outlook is provided to the dataset of compressed video for study of quality metrics (CVQM) which is currently being developed in AG 5 and which includes reconstructed video sequences from a set of conventional and learning-based coding schemes. https://cassyni-user-files-prod.s3.amazonaws.com/6qKhjKm9ARp7piFPHUHu3k https://cassyni.com/events/UP4L4Ejmhv5cuBERSLMj9P/abstract https://cassyni-user-files-prod.s3.amazonaws.com/MHZy6RZafDBpXuZTdvphwU https://cassyni.com/slides/outline/G2nyftXsvkNyz1GFV8g1n5 https://cassyni.com/events/G2nyftXsvkNyz1GFV8g1n5/abstract https://cassyni-user-files-prod.s3.amazonaws.com/FBhNGto2vhs9k4zSZGFsjt https://cassyni.com/events/G2nyftXsvkNyz1GFV8g1n5?videoPreview=1 The subspace structure of free Banach latticesnohttps://cassyni.com/events/G2nyftXsvkNyz1GFV8g1n5?videoPreview=12021-04-01T14:00:00+00:002962.72Positivity Journal, SpringerNatureGiven a Banach space E, one can associate a Banach lattice FBL[E], with the property that every bounded operator from E to a Banach lattice X extends uniquely to a lattice homomorphism from FBL[E] into X. We will discuss recent progress towards understanding the structure of FBL[E], and its relation to classical topics in Banach space theory.https://cassyni-user-files-prod.s3.amazonaws.com/FBhNGto2vhs9k4zSZGFsjt https://cassyni.com/events/AbfLANR76iHub921tDgDnd/abstract https://cassyni-user-files-prod.s3.amazonaws.com/FrMsseC2urYgVa9VY9V174 https://cassyni.com/events/LUf3CfsVHEHxb8iSgMP2ZB/abstract https://cassyni-user-files-prod.s3.amazonaws.com/CDR3VwrtbL4hzgdzQ7ZeBg https://cassyni.com/events/TtP6tvaMs6bo5iEueEEkyB/abstract https://cassyni-user-files-prod.s3.amazonaws.com/QjULFy8mzFTeTwRvDUYKHp https://cassyni.com/slides/outline/6eW7uXknzQnUwxFjmg2cpM https://cassyni.com/events/6eW7uXknzQnUwxFjmg2cpM/abstract https://cassyni-user-files-prod.s3.amazonaws.com/P4b44RzsYL76zHL53AMbsL https://cassyni.com/events/6eW7uXknzQnUwxFjmg2cpM?videoPreview=1 Incorporating information from reference genomes with semi-supervised deep learning leads to better metagenomic assembled genomes (MAGs)nohttps://cassyni.com/events/6eW7uXknzQnUwxFjmg2cpM?videoPreview=12021-10-14T13:00:00+00:00640.2Microbiome Virtual International Forum High-throughput sequencing is commonly used to study microorganisms in the environment without a need for culturing. Computational analysis of metagenomic has enabled the construction of large compendia of metagenome-assembled genomes (MAGs) from human-, animal-associated and environmental samples. Metagenomic binning is the step in the standard pipeline which groups the contigs into bins such that each bin is predicted to contain only contigs from the same genome. Binning methods can be divided into reference-dependent (based on reference genomes) and reference-independent methods (operating de novo). Compared to reference-dependent methods, reference-independent methods can discover new species or even new phyla, but completely ignore any background information. To combine the advantages of these two categories, we propose a novel binning method called SemiBin which uses a semi-supervised neural network to incorporate information from reference genomes, while still being capable of finding novel species. SemiBin outperforms existing state-of-the-art binning methods in simulated and real microbiome datasets across three different environments (human gut, dog gut, and marine environments). SemiBin returns more high-quality bins (48.0-99.2% more in single-sample mode; 11.0-30.7% more in multi-sample mode, compared to the second-best alternative). Compared to the alternatives, SemiBin captures a larger taxonomic diversity, including more distinct genera and species. In particular, we verified that SemiBin can retrieve more genomes from both known and novel species. SemiBin is available as open source software at https://github.com/BigDataBiology/SemiBin/.https://cassyni-user-files-prod.s3.amazonaws.com/P4b44RzsYL76zHL53AMbsL https://cassyni.com/slides/outline/799ixDQKRsLXwindN7KR5f https://cassyni.com/events/799ixDQKRsLXwindN7KR5f/abstract https://cassyni-user-files-prod.s3.amazonaws.com/V625horCAhsS17duajoMFt https://cassyni.com/events/799ixDQKRsLXwindN7KR5f?videoPreview=1 Evolution of microbiomes and the evolution of the study and politics of microbiomes (or, how can something be both ridiculously overhyped and horrifically underappreciated)nohttps://cassyni.com/events/799ixDQKRsLXwindN7KR5f?videoPreview=12021-12-08T17:00:00+00:002408.04Microbiome Virtual International Forum Panel discussion with Jonathan Eisen, Clara Belzer, and Rick Bushman, chaired by Nicola Segata, following Jonathan Eisen's Keynote talk Evolution of microbiomes and the evolution of the study and politics of microbiomes (or, how can something be both ridiculously overhyped and horrifically underappreciated)https://cassyni-user-files-prod.s3.amazonaws.com/V625horCAhsS17duajoMFt https://cassyni.com/events/i25ShHYbqFTYrYPmCKd6D/abstract https://cassyni-user-files-prod.s3.amazonaws.com/FQgJQz3fkYAbDVpRbn8eN2 https://cassyni.com/events/i25ShHYbqFTYrYPmCKd6D?videoPreview=1 Processed foods drive intestinal barrier permeability and microvascular diseasesnohttps://cassyni.com/events/i25ShHYbqFTYrYPmCKd6D?videoPreview=12022-02-08T14:00:00+00:0060.16Microbiome Virtual International Forum Intake of processed foods has increased markedly over the past decades, coinciding with increased microvascular diseases such as chronic kidney disease (CKD) and diabetes. Here, we show in rodent models that long-term consumption of a processed diet drives intestinal barrier permeability and an increased risk of CKD. Inhibition of the advanced glycation pathway, which generates Maillard reaction products within foods upon thermal processing, reversed kidney injury. Consequently, a processed diet leads to innate immune complement activation and local kidney inflammation and injury via the potent proinflammatory effector molecule complement 5a (C5a). In a mouse model of diabetes, a high resistant starch fiber diet maintained gut barrier integrity and decreased severity of kidney injury via suppression of complement. These results demonstrate mechanisms by which processed foods cause inflammation that leads to chronic disease. Link to OA paper: https://www.science.org/doi/10.1126/sciadv.abe4841https://cassyni-user-files-prod.s3.amazonaws.com/FQgJQz3fkYAbDVpRbn8eN2 https://cassyni.com/slides/outline/E4EBbnTfaH6KSXnCjYtMEM https://cassyni.com/events/E4EBbnTfaH6KSXnCjYtMEM/abstract https://cassyni-user-files-prod.s3.amazonaws.com/49H4sHgC15vApguBTNtenr https://cassyni.com/events/E4EBbnTfaH6KSXnCjYtMEM?videoPreview=1 Toward the development of defined microbial therapeuticsnohttps://cassyni.com/events/E4EBbnTfaH6KSXnCjYtMEM?videoPreview=12022-06-15T10:00:00+00:002000.0Microbiome Virtual International Forum Trillions of microorganisms transit through and reside in the mammalian gastrointestinal tract each day, collectively producing thousands of small molecules and metabolites with local and systemic effects on host physiology. Identifying effector microorganisms that causally affect host phenotype and deciphering the underlying mechanisms have become foci of microbiome research and have begun to enable the development of microbiota-based therapeutics. Two complementary, reductionist approaches have commonly been used: the first starts with a specific phenotype (such as immune cell induction) and narrows down the microbiota to identify responsible effector bacteria, while the second starts with bacteria-derived molecules and metabolites and seeks to understand their effects on the human physiology. Together, these strategies provide the basis for the rational design of microbiota-targeted therapeutics to ameliorate specific diseases and conditions.https://cassyni-user-files-prod.s3.amazonaws.com/49H4sHgC15vApguBTNtenr https://cassyni.com/slides/outline/GXUCqChHmZrooUFmHEnyxH https://cassyni.com/events/GXUCqChHmZrooUFmHEnyxH/abstract https://cassyni-user-files-prod.s3.amazonaws.com/TPNafvyFzXfEcu8XvYC98a https://cassyni.com/events/GXUCqChHmZrooUFmHEnyxH?videoPreview=1 Gut microbiota of the threatened takahē: biogeographic patterns and conservation implicationsnohttps://cassyni.com/events/GXUCqChHmZrooUFmHEnyxH?videoPreview=12022-10-18T10:00:00+00:0061.04Microbiome Virtual International Forum The Aotearoa New Zealand takahē (Porphyrio hochstetteri), once thought to be extinct, is a nationally threatened flightless rail under intensive conservation management. While there has been previous research into disease-related microbes in takahē, little is known about the microbes present in the gastrointestinal tract. Given the importance of gut-associated microbes to herbivore nutrition and immunity, knowledge of these communities is likely to be of considerable conservation value. Here we examined the gut microbiotas of 57 takahē at eight separate locations across Aotearoa New Zealand. Faecal samples, taken as a proxy for the hindgut bacterial community, were subjected to 16S rRNA gene amplicon sequencing using Illumina MiSeq. Phylogenetic analysis of more than 2200 amplicon sequence variants (ASVs) revealed nine main bacterial phyla (Acidobacteriota, Actinobacteriota, Bacteroidota, Campilobacterota, Firmicutes, Fusobacteriota, Planctomycetota, Proteobacteria, and Verrucomicrobiota) that accounted for the majority of sequence reads. Location was a significant effect (p value lower than 0.001, 9999 permutations) that accounted for 32% of the observed microbiota variation. One ASV, classified as Lactobacillus aviarius, was present in all samples at an average relative abundance of 17% (SD = 23.20). There was strong evidence (p = 0.002) for a difference in the abundance of the genus Lactobacillus between locations. A common commensal bacterium previously described in takahē, Campylobacter spp., was also detected in most faecal samples. Location plays a pivotal role in the observed variation among takahē gut bacterial communities and is potentially due to factors such as supplemental feeding and medical treatment experienced by birds housed in captivity at one of the eight sampled sites. These data present a first glimpse of the previously unexplored takahē gut microbiota and provide a baseline for future microbiological studies and conservation efforts. Link to OA paper: https://animalmicrobiome.biomedcentral.com/articles/10.1186/s42523-021-00158-5#Abs1https://cassyni-user-files-prod.s3.amazonaws.com/TPNafvyFzXfEcu8XvYC98a https://cassyni.com/slides/outline/97k98wzRBhZJ3S4rj5BMWD https://cassyni.com/events/97k98wzRBhZJ3S4rj5BMWD/abstract https://cassyni-user-files-prod.s3.amazonaws.com/NwY9Fn9Y3QfzAFNk1tRZz6 https://cassyni.com/events/97k98wzRBhZJ3S4rj5BMWD?videoPreview=1 Time of Sample Collection Critical for Microbiome Replicabilitynohttps://cassyni.com/events/97k98wzRBhZJ3S4rj5BMWD?videoPreview=12022-12-14T11:00:00+00:0065.72Microbiome Virtual International Forum Although many aspects of microbiome studies have been standardized to improve experimental replicability, none account for how the daily diurnal fluctuations in the gut lumen cause dynamic changes in 16S amplicon sequencing. Here we show that sample collection time affects the conclusions drawn from microbiome studies and are larger than the effect size of a daily experimental intervention or dietary changes. The timing of divergence of the microbiome composition between experimental and control groups are unique to each experiment. Sample collection times as short as only four hours apart lead to vastly different conclusions. Lack of consistency in the time of sample collection may explain poor cross-study replicability in microbiome research. Without looking at other data, the impact on other fields is unknown but potentially significant. Link to OA paper: https://www.biorxiv.org/content/10.1101/2022.10.26.513817v1https://cassyni-user-files-prod.s3.amazonaws.com/NwY9Fn9Y3QfzAFNk1tRZz6 https://cassyni.com/slides/outline/PwDte5v3ko6NSXUdXgb9zu https://cassyni.com/events/PwDte5v3ko6NSXUdXgb9zu/abstract https://cassyni-user-files-prod.s3.amazonaws.com/VbxL1TCV8m2xNhrBu8RDKk https://cassyni.com/events/PwDte5v3ko6NSXUdXgb9zu?videoPreview=1 Healthy collaboration: sharing the benefits and considering the consequencesnohttps://cassyni.com/events/PwDte5v3ko6NSXUdXgb9zu?videoPreview=12024-05-21T12:00:00+00:00738.12Microbiome Virtual International Forum In this talk, I will explore how microbiome research benefits from collaboration across researchers and between researchers and communities. I will also discuss the challenges these relationships create in terms of credit, data access, and perceived versus actual knowledge benefits. While global collaborations are essential for addressing big scientific questions, they also run the risk of creating extractive practices at multiple levels.https://cassyni-user-files-prod.s3.amazonaws.com/VbxL1TCV8m2xNhrBu8RDKk https://cassyni.com/slides/outline/JW6F8ZoGvm1J3fEPvmbN1T https://cassyni.com/events/JW6F8ZoGvm1J3fEPvmbN1T/abstract https://cassyni-user-files-prod.s3.amazonaws.com/8yuySYTDDFrbi1scfTgW2S https://cassyni.com/events/JW6F8ZoGvm1J3fEPvmbN1T?videoPreview=1 No evidence for a common blood microbiome based on a population study of 9,770 healthy humansnohttps://cassyni.com/events/JW6F8ZoGvm1J3fEPvmbN1T?videoPreview=12023-10-17T12:00:00+00:00738.04Microbiome Virtual International Forum Human blood is conventionally considered sterile but recent studies suggest the presence of a blood microbiome in healthy individuals. Here we characterized the DNA signatures of microbes in the blood of 9,770 healthy individuals using sequencing data from multiple cohorts. After filtering for contaminants, we identified 117 microbial species in blood, some of which had DNA signatures of microbial replication. They were primarily commensals associated with the gut (n = 40), mouth (n = 32) and genitourinary tract (n = 18), and were distinct from pathogens detected in hospital blood cultures. No species were detected in 84% of individuals, while the remainder only had a median of one species. Less than 5% of individuals shared the same species, no co-occurrence patterns between different species were observed and no associations between host phenotypes and microbes were found. Overall, these results do not support the hypothesis of a consistent core microbiome endogenous to human blood. Rather, our findings support the transient and sporadic translocation of commensal microbes from other body sites into the bloodstream. Link to OA paper: https://www.nature.com/articles/s41564-023-01350-whttps://cassyni-user-files-prod.s3.amazonaws.com/8yuySYTDDFrbi1scfTgW2S https://cassyni.com/slides/outline/JzjrBFSoNDZM3RmHXCtAGm https://cassyni.com/events/JzjrBFSoNDZM3RmHXCtAGm/abstract https://cassyni-user-files-prod.s3.amazonaws.com/9r5QPNMGPAkVnJERagLhR8 https://cassyni.com/events/JzjrBFSoNDZM3RmHXCtAGm?videoPreview=1 aMeta: a computational method for data-driven ancient metagenomic analysisnohttps://cassyni.com/events/JzjrBFSoNDZM3RmHXCtAGm?videoPreview=12024-01-09T11:00:00+00:00949.0Microbiome Virtual International Forum Analysis of microbial data from archaeological samples is a growing field with great potential for understanding ancient environments, lifestyles, and diseases. However, high error rates have been a challenge in ancient metagenomics, and the availability of computational frameworks that meet the demands of the field is limited. Here, we propose aMeta [1], an accurate metagenomic profiling workflow for ancient DNA designed to minimize the amount of false discoveries and computer memory requirements. Using simulated data, we benchmark aMeta against a current state-of-the-art workflow and demonstrate its superiority in microbial detection and authentication, as well as substantially lower usage of computer memory. Link to OA paper: https://genomebiology.biomedcentral.com/articles/10.1186/s13059-023-03083-9https://cassyni-user-files-prod.s3.amazonaws.com/9r5QPNMGPAkVnJERagLhR8 https://cassyni.com/slides/outline/VNMY9c2paqBmZw4RYJq3xH https://cassyni.com/events/VNMY9c2paqBmZw4RYJq3xH/abstract https://cassyni-user-files-prod.s3.amazonaws.com/QVsiLfzFbRmQoBCT5tGm7C https://cassyni.com/events/VNMY9c2paqBmZw4RYJq3xH?videoPreview=1 Questioning the fetal microbiome illustrates pitfalls of low-biomass microbial studiesnohttps://cassyni.com/events/VNMY9c2paqBmZw4RYJq3xH?videoPreview=12023-05-17T12:00:00+00:00852.04Microbiome Virtual International Forum Whether the human fetus and the prenatal intrauterine environment (amniotic fluid and placenta) are stably colonized by microbial communities in a healthy pregnancy remains a subject of debate. Here we evaluate recent studies that characterized microbial populations in human fetuses from the perspectives of reproductive biology, microbial ecology, bioinformatics, immunology, clinical microbiology and gnotobiology, and assess possible mechanisms by which the fetus might interact with microorganisms. Our analysis indicates that the detected microbial signals are likely the result of contamination during the clinical procedures to obtain fetal samples or during DNA extraction and DNA sequencing. Furthermore, the existence of live and replicating microbial populations in healthy fetal tissues is not compatible with fundamental concepts of immunology, clinical microbiology and the derivation of germ-free mammals. These conclusions are important to our understanding of human immune development and illustrate common pitfalls in the microbial analyses of many other low-biomass environments. The pursuit of a fetal microbiome serves as a cautionary example of the challenges of sequence-based microbiome studies when biomass is low or absent, and emphasizes the need for a trans-disciplinary approach that goes beyond contamination controls by also incorporating biological, ecological and mechanistic concepts https://cassyni-user-files-prod.s3.amazonaws.com/QVsiLfzFbRmQoBCT5tGm7C https://cassyni.com/slides/outline/XqKLEj7akWh39KLC9REzeH https://cassyni.com/events/XqKLEj7akWh39KLC9REzeH/abstract https://cassyni-user-files-prod.s3.amazonaws.com/HYqLwa6rJatY26JSsDViSJ https://cassyni.com/events/XqKLEj7akWh39KLC9REzeH?videoPreview=1 Dynamics in Fractal Spacesnohttps://cassyni.com/events/XqKLEj7akWh39KLC9REzeH?videoPreview=12025-07-03T14:00:00+00:00647.2NODYSFractal geometry, introduced by Benoit Mandelbrot, provides a framework for analyzing natural patterns, emphasizing scale invariance and intricate structures crucial to studying complex systems. This work explores fractal geometry’s mathematical foundations via Felix Hausdorff’s framework, incorporating fractional dimensions and mass distribution metrics, making fractal analysis useful for physical and biological systems. Fractal calculus extends traditional calculus by integrating Hausdorff's mass distribution, supporting fractal differential equations like the Fokker-Planck Equation (FPE) for modelling complex systems. Fractional derivatives, modelling anomalous diffusion, serve as continuous approximations of fractal derivatives. The fractal FPE’s approximation yields the Plastino-Plastino Equation (PPE), linking to Tsallis statistics, relevant in fields like urban scaling, high-energy physics, and deforestation, showing fractal models' value in complex phenomena.https://cassyni-user-files-prod.s3.amazonaws.com/HYqLwa6rJatY26JSsDViSJ https://cassyni.com/slides/outline/SQBgjCzovUbxkT5xYWFCeq https://cassyni.com/events/SQBgjCzovUbxkT5xYWFCeq/abstract https://cassyni-user-files-prod.s3.amazonaws.com/DyALUFBBXNoy8TsFSWYjTC https://cassyni.com/events/SQBgjCzovUbxkT5xYWFCeq?videoPreview=1 Enhanced Resolution in Nonlinear NEMS-Based Optomechanical Frequency Combsnohttps://cassyni.com/events/SQBgjCzovUbxkT5xYWFCeq?videoPreview=12025-06-24T10:00:00+00:00724.0NODYSIn this work, we present a novel method for generating and tuning OMFCs by modulating an optical mode with nano-electromechanical systems (NEMS) resonator driven into primary resonance. Operating within the nonlinear regime, we achieve two distinct combs with different free spectral ranges (FSR) using the same NEMS. The optical signal is modulated in both cases with an FSR equal to the mechanical (NEMS) frequency facilitating synchronized phonon-photon interactions.https://cassyni-user-files-prod.s3.amazonaws.com/DyALUFBBXNoy8TsFSWYjTC https://cassyni.com/slides/outline/StqHmteLMwA1kDcr8wXzv9 https://cassyni.com/events/StqHmteLMwA1kDcr8wXzv9/abstract https://cassyni-user-files-prod.s3.amazonaws.com/EayLn6jb5CW6DhV95S2Pdg https://cassyni.com/events/StqHmteLMwA1kDcr8wXzv9?videoPreview=1 A Comparison of Nonlinear Dimensionality Reduction Algorithms Applied on Alzheimer MRInohttps://cassyni.com/events/StqHmteLMwA1kDcr8wXzv9?videoPreview=12025-06-24T11:00:00+00:00690.04NODYSThe study presented in this paper focuses on comparing Nonlinear Dimensionality Reduction (NLDR) techniques applied on an MRI dataset for Alzheimer's disease classification. Given the increasing prevalence of Alzheimer’s disease and the necessity for early and accurate diagnosis, our research aims to enhance diagnostic methods using advanced data analysis techniques. Magnetic Resonance Imaging (MRI) is a critical tool for observing the structural changes in the brain associated with Alzheimer’s. However, the high-dimensional nature of MRI data poses significant challenges for effective analysis. Linear Dimensionality Reduction (LDR) methods are often inadequate for capturing the complex, nonlinear relationships in the data. Therefore, our study explores the application of NLDR algorithms such as Isomap, Locally Linear Embedding (LLE), Diffusion Maps and t-Distributed Stochastic Neighbor Embedding (t-SNE) to address these challenges. The research involves a comparative analysis of these NLDR techniques in terms of their ability to preserve the structural integrity of the MRI data and their impact on the performance of classification models for Alzheimer’s disease. We used the most common metrics for clustering performance and we trained a classification model to determine the impact on classification. The results indicate that the application of these methods are able to capture the intrinsic geometric relationships between data points and increase the classification metrics. The best results come from the t-SNE technique with the lowest number of dimensions needed and the biggest improvements in classification. This study aims to contribute to the advancement of Alzheimer’s disease diagnosis through the application of sophisticated data reduction techniques, providing insights for future research in optimizing NLDR methods for clinical use.https://cassyni-user-files-prod.s3.amazonaws.com/EayLn6jb5CW6DhV95S2Pdg https://cassyni.com/slides/outline/5exJnVpmVFLhcTdgGPKrmK https://cassyni.com/events/5exJnVpmVFLhcTdgGPKrmK/abstract https://cassyni-user-files-prod.s3.amazonaws.com/99qhGacpFAQy9cUgZR8sMx https://cassyni.com/events/5exJnVpmVFLhcTdgGPKrmK?videoPreview=1 Dynamics of Vibro-Impact Capsules in Heterogeneous Intestinal Fluid Environmentsnohttps://cassyni.com/events/5exJnVpmVFLhcTdgGPKrmK?videoPreview=12025-06-24T11:00:00+00:00579.84NODYSThis paper presents a comprehensive analysis of vibro-impact capsule locomotion through simulated intestinal fluid media with varying physicochemical properties. Employing an advanced bidirectional fluid-structure interaction modelling approach, we systematically examine capsule dynamics across a spectrum of fluid conditions. The study integrates computational fluid dynamics with structural mechanics to quantify the complex interplay between hydrodynamic resistance and capsule propulsion characteristics. Our findings establish predictive correlations between fluid parameters and dynamic performance, offering substantive improvements for capsule robot’s design and optimization.https://cassyni-user-files-prod.s3.amazonaws.com/99qhGacpFAQy9cUgZR8sMx https://cassyni.com/slides/outline/DZMbe4h3uw8MvW9f2NJZMX https://cassyni.com/events/DZMbe4h3uw8MvW9f2NJZMX/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Xr83M4yUcD4LCbxE3U8mfC https://cassyni.com/events/DZMbe4h3uw8MvW9f2NJZMX?videoPreview=1 Laser-plasma-based sources of positron beamsnohttps://cassyni.com/events/DZMbe4h3uw8MvW9f2NJZMX?videoPreview=12025-06-26T15:00:00+00:002525.84Journal of Plasma PhysicsIt is widely accepted that the next lepton collider beyond a Higgs factory would require center-of-mass energy of the order of up to 15 TeV. Plasma based acceleration is considered a promising concept for the next generation of linear electron-positron colliders. Despite the great progress achieved over the last twenty years in laser technology, laser- and beam-driven particle acceleration, and special target availability, positron acceleration remains significantly underdeveloped if compared to electron acceleration. This is due to both the specifics of the plasma-based acceleration, and the lack of adequate positron sources tailored for the subsequent plasma based acceleration. Here several designs for laser plasma based positron sources are discussed. First, a set of compact, two-stage plasma-based positron sources is presented. In the first stage the positrons are created by a multi GeV electron beam produced by a laser-plasma accelerator interacting with a solid density foil. In the second stage the positrons are captured and accelerated in a plasma wave driven by either an electron beam or a laser pulse. Second, a positron source based on the collision of a high energy electron beam with a high intensity laser pulse is proposed. The source relies on the subsequent multi-photon Compton and Breit-Wheeleer processes to generate an electron-positron pair out of a high energy photon emitted by an electron. The remarkable property of this source is that low divergence positron beams can be generated by employing frequency doubled and quadrupled laser pulses. The resulting low emittance in the sub-micron range potentially makes such source interesting for collider applications.https://cassyni-user-files-prod.s3.amazonaws.com/Xr83M4yUcD4LCbxE3U8mfC https://cassyni.com/slides/outline/A6pNKHANqjFitor6Nhvbph https://cassyni.com/events/A6pNKHANqjFitor6Nhvbph/abstract https://cassyni-user-files-prod.s3.amazonaws.com/SfKCMtgTzuFJeEMYhKjEwY https://cassyni.com/events/A6pNKHANqjFitor6Nhvbph?videoPreview=1 Gyrokinetic studies on momentum transport and energy exchangenohttps://cassyni.com/events/A6pNKHANqjFitor6Nhvbph?videoPreview=12024-05-16T15:00:00+00:003466.8Journal of Plasma PhysicsGoverning equations of electromagnetic turbulent plasma systems are derived from the variational principle for the action integral of the Lagrangian based on gyrokinetics. It is shown in the first part of this colloquium that the invariance of the Lagrangian of the system under an arbitrary spatial coordinate transformation can be used to derive the local momentum balance equation. The symmetric pressure tensor representing the local momentum transport is directly derived from the variational derivative of the Lagrangian with respect to the metric tensor. The derived symmetric pressure tensor is useful to treat momentum conservation in symmetric magnetic configurations. In the second part, gyrokinetic simulation results of turbulent energy exchange between electrons and ions in ITG turbulence are presented. In low collisional plasmas, turbulent effects dominate over energy exchange. Energy transfer from ions to electrons occurs due to the ITG turbulence even when electrons are hotter than ions. In addition, quasilinear modeling of the turbulent energy exchange is discussed based on comparison between linear and nonlinear simulation results.https://cassyni-user-files-prod.s3.amazonaws.com/SfKCMtgTzuFJeEMYhKjEwY https://cassyni.com/slides/outline/Ca4PYhQ1322DFkKevPqEYd https://cassyni.com/events/Ca4PYhQ1322DFkKevPqEYd/abstract https://cassyni-user-files-prod.s3.amazonaws.com/MUWMNiPTPbRrzsts7GJ9hQ https://cassyni.com/events/Ca4PYhQ1322DFkKevPqEYd?videoPreview=1 Resonant axisymmetric modes in tokamak fusion plasmasnohttps://cassyni.com/events/Ca4PYhQ1322DFkKevPqEYd?videoPreview=12024-11-21T16:00:00+00:002863.12Journal of Plasma PhysicsThe impact of divertor X-points on axisymmetric modes (toroidal mode number n=0) in tokamak plasmas is discussed. Axisymmetric perturbations, such as vertical displacements, can lead to current sheets localized in the vicinity of magnetic X-points and extending along the magnetic divertor separatrix, likely to have a profound impact on disruptions and MHD edge stability. When a nearby resistive wall is present, the vertical mode can still grow on the relatively slow resistive wall time scale. Active feedback control is then required for complete stabilization. However, it is shown that the resistive growth rate can be significantly faster, scaling with fractional powers of wall resistivity, if the wall position satisfies the criterion for ideal-MHD marginal stability, thus posing more stringent conditions for active feedback stabilization. Furthermore, it is shown that so-called Vertical Displacements Oscillatory Modes (VDOM) can be excited. These modes have a frequency of oscillation scaling with the poloidal Alfvén frequency. They are normally damped by wall resistivity, but can be driven unstable by the resonant interaction with fast ions, leading to a new type of fast ion driven mode. Instability requires a fast ion distribution with a positive slope, or with a significant anisotropy, in velocity space. Scenarios for the required fast ion population are discussed. Numerical simulations of VDOM using the NIMROD extended-MHD code are presented. This theory may explain the observation of saturated n=0 fluctuations in recent JET experiments.https://cassyni-user-files-prod.s3.amazonaws.com/MUWMNiPTPbRrzsts7GJ9hQ https://cassyni.com/slides/outline/Ly7HSwuouAMvZZNXGp6jQ9 https://cassyni.com/events/Ly7HSwuouAMvZZNXGp6jQ9/abstract https://cassyni-user-files-prod.s3.amazonaws.com/NNd53SUkPUs76r9n3VqjJW https://cassyni.com/events/Ly7HSwuouAMvZZNXGp6jQ9?videoPreview=1 1/f noise in the solar wind: connections to dynamo, inverse cascade and causalitynohttps://cassyni.com/events/Ly7HSwuouAMvZZNXGp6jQ9?videoPreview=12023-08-17T15:00:00+00:003212.52Journal of Plasma PhysicsI review the observations of 1/f noise in the heliosphere and discuss the theoretical background of generic 1/f noise models as they may be relevant to the solar wind. The planning for Parker Solar Probe emphasized that understanding 1/f “noise” in the solar wind may inform central problems in heliospheric physics such as the solar dynamo, coronal heating, the origin of the solar wind, and the nature of interplanetary turbulence [1]. It is of significance that 1/f noise can occur in a great variety of physical systems ranging from Johnson noise in vacuum tubes and semiconductors, fluctuations in heart rates, brain waves sandpiles [2], and solids [3], the spectrum of music and economic indicators, and many other examples. An appealing generic mechanism that can explain many of these phenomena is the superposition principle [4,5] in which a composite signal is formed from a collection of individual signals that are characterized by scale-invariant correlation times. In the solar wind context, it was proposed [4] that such a superposition might occur in the corona due to scale-invariant reconnections, thus explaining the observed 1/f signal in the interplanetary magnetic field that spans the approximate frequency range 2 x 10^-6 Hz to several times 10^-4 Hz. at 1 au. Subsequent observational analyses showed that signals in the photosphere and the corona [5,6] exhibit 1/f signatures at frequency ranges compatible with the 1 au observations. This suggests an even lower altitude origin in the dynamo itself and this possibility is supported by both dynamo experiments and simulations [7]. There is also empirical evidence that inverse cascade systems (including dynamo) generically exhibit 1/f noise, possibly due to nonlocality of interactions at the largest scales. Recent interest in employing Parker Solar Probe observations to address whether interplanetary 1/f noise can be generated by local dynamics [as proposed e.g., in 8, 9,10] is also reviewed. Here we present theoretical arguments that due to causality issues, interplanetary 1/f noise extending to very low frequencies is not explained by the recent observations.https://cassyni-user-files-prod.s3.amazonaws.com/NNd53SUkPUs76r9n3VqjJW https://cassyni.com/slides/outline/PSMJgN9S6T8QvVr5pW1N85 https://cassyni.com/events/PSMJgN9S6T8QvVr5pW1N85/abstract https://cassyni-user-files-prod.s3.amazonaws.com/QSPyepGc2LkVi2Rm5bH3FC https://cassyni.com/events/PSMJgN9S6T8QvVr5pW1N85?videoPreview=1 New insights on plasma turbulence in the boundary region of tokamaksnohttps://cassyni.com/events/PSMJgN9S6T8QvVr5pW1N85?videoPreview=12023-01-19T16:00:00+00:002836.16Journal of Plasma PhysicsOne of the greatest uncertainties in the success of the fusion program is related to the turbulent dynamics of the fusion fuel in the boundary region. The plasma behavior in the boundary governs the overall confinement properties of the device, regulates the impurity dynamics and the level of fusion ashes, and determines the heat load to the vessel walls – a showstopper for the whole fusion program if material requirements cannot be met. With the goal of improving our understanding of the boundary dynamics, the GBS code was developed during the past years. By solving the drift-reduced Braginskii equations self-consistently with the kinetic neutral atom dynamics, GBS simulates the plasma turbulence in the boundary of tokamaks as it results from external sources, recycling, turbulent transport and flows, and plasma losses at the vessel. GBS simulations have allowed us to advance the basic understanding of boundary turbulence. This incudes progress in estimating the SOL width, a crucial quantity to determine the heat flux on the vessel walls, and the identification of a turbulent regime characterized by a catastrophically large turbulent transport, which has been associated with the crossing of the density limit. We will present an overview of our simulation and theoretical results, as well as their comparison with experimental measurements from several tokamaks worldwide. Predictions for ITER and other future reactors will be discussed.https://cassyni-user-files-prod.s3.amazonaws.com/QSPyepGc2LkVi2Rm5bH3FC https://cassyni.com/slides/outline/Kyp5Macm2FFmtoYXAqdQbF https://cassyni.com/events/Kyp5Macm2FFmtoYXAqdQbF/abstract https://cassyni-user-files-prod.s3.amazonaws.com/K1GL9J9qCJfNdwRJZaPWyU https://cassyni.com/events/Kyp5Macm2FFmtoYXAqdQbF?videoPreview=1 Compressed Current Sheets in the Magnetotail: Importance of the Ambipolar Electric Fieldnohttps://cassyni.com/events/Kyp5Macm2FFmtoYXAqdQbF?videoPreview=12022-07-28T15:00:00+00:002649.64Journal of Plasma PhysicsMicro-scale features are now being resolved by NASA’s Magnetospheric Multi-Scale (MMS) mission, which means for the first time, we are able to investigate thin and non-ideal current sheets (i.e. current sheets that cannot be explained by the Harris equilibrium model) in detail and assess their role in magnetic reconnection. We use MMS satellite data to analyze kinetic-scale structures and dynamics associated with compressed current sheets. Our analysis shows that a transverse ambipolar electric field is localized to the region of lower hybrid fluctuations and the pressure gradient in this region is comparatively small, leading to the interpretation that compression of the current sheet and the resulting velocity shear is the underlying fluctuation driving mechanism. Our kinetic equilibrium model shows that as a large scale Harris current sheet is compressed, an ambipolar electric field forms and produces velocity shear near the magnetic null, indicating that velocity shear-driven waves can arise in the center of compressed current sheets. The presence and location of shear-driven waves at the center of current sheets is notable for a couple of reasons. First, because laboratory experiments and PIC simulations have shown that shear-driven lower hybrid fluctuations are capable of producing significant anomalous cross-field transport and resistivity, which can trigger magnetic reconnection. Second, using MMS wave data we can calculate the anomalous resistivity directly and show that the resistivity is significant, particularly at the magnetic null. Finally, we show that the electron distribution function is non-gyrotropic, which theoretical arguments suggest is an indicator of the possibility for magnetic reconnection to occur. Our kinetic equilibrium shows that such non-gyrotropic distribution functions can be generated by a quasi-static electric field and does not necessarily arise from wave induced effects.https://cassyni-user-files-prod.s3.amazonaws.com/K1GL9J9qCJfNdwRJZaPWyU https://cassyni.com/events/WMRmKwCnErtCRJqfBwaJGm/abstract https://cassyni.com/slides/outline/Wr5NNcrJgKSFR5NYnNs6Y5 https://cassyni.com/events/Wr5NNcrJgKSFR5NYnNs6Y5/abstract https://cassyni-user-files-prod.s3.amazonaws.com/FfaepksHoVk68wm6AD3miv https://cassyni.com/events/Wr5NNcrJgKSFR5NYnNs6Y5?videoPreview=1 The magnetised plasma sheath and its role in the boundary of magnetic fusion devicesnohttps://cassyni.com/events/Wr5NNcrJgKSFR5NYnNs6Y5?videoPreview=12021-10-21T15:00:00+00:003207.92Journal of Plasma PhysicsSheaths form wherever a plasma is in contact with a solid target. They are characterised by a spatial variation of the electrostatic potential and density over very small length scales normal to the surface. Within a few Debye lengths of the target, the electric field is so strong that the plasma is non-neutral. Debye sheaths exist in order to repel electrons, which are lighter and more mobile than ions. When a magnetic field is present in the plasma at an oblique angle with the target, the sheath develops a two-scale structure, with a part of the electrostatic potential variation occurring in a larger quasineutral magnetic presheath (or Chodura sheath) a few ion gyro radii from the target. When simulating turbulence in the open field line region (Scrape-Off Layer) of a fusion device, it is numerically prohibitive to resolve the small timescales and length scales of the magnetised sheath, which comprises the magnetic presheath and Debye sheath. Instead, an iterative method can be used to directly obtain numerical solutions for the electrostatic potential in the magnetised sheath in steady state. This is demonstrated using a fully kinetic model exploiting the grazing magnetic field angle (typical of fusion devices) to approximate the ion and electron trajectories. Numerical solutions include the ion distribution function reaching the target, important for sputtering predictions. Analytical calculations show that the kinetic Chodura condition must be satisfied by the ion distribution function reaching the magnetised sheath from the rest of the plasma. The implications of this for boundary conditions to gyrokinetic codes of the open field line region are discussed.https://cassyni-user-files-prod.s3.amazonaws.com/FfaepksHoVk68wm6AD3miv https://cassyni.com/events/RQwis6jXrHMB2D8KBTsJYd/abstract https://cassyni.com/events/69fA4SW4jRkJFd5pGAGzrR/abstract https://cassyni.com/events/8cuBHrjgviWncZZNorBdaM/abstract https://cassyni.com/slides/outline/B55YBMPdpJ5z7mpLAoQFgR https://cassyni.com/events/B55YBMPdpJ5z7mpLAoQFgR/abstract https://cassyni-user-files-prod.s3.amazonaws.com/3TxRDRT4QUyJiVb5uUrPMg https://cassyni.com/events/B55YBMPdpJ5z7mpLAoQFgR?videoPreview=1 Effect of regional anesthesia on discharge opioid prescription practices following pediatric interventional radiology sclerotherapy: A follow up studynohttps://cassyni.com/events/B55YBMPdpJ5z7mpLAoQFgR?videoPreview=12025-10-15T09:44:30+00:00974.44Society for Pediatric Interventional Radiology## Introduction The peri-procedural opioid-sparing effect of regional anesthesia during pediatric interventional radiology (IR) sclerotherapy for bone cysts, venous malformations, and lymphatic malformations has been demonstrated, though its impact on post-discharge opioid prescribing remains unclear. ## Materials and Methods A retrospective study was originally conducted at a single tertiary-care children’s hospital examining the analgesic utility of nerve blocks during IR-performed sclerotherapy for these indications between January 2016 and May 2025. Venous and lymphatic malformations were combined for final analysis. Data on discharge opioid prescriptions were obtained through the Illinois Prescription Monitoring Program and re-analyzed for predictive factors. ## Results 482 patients were included in final analysis. 189 (39.2%) received opioids at discharge, primarily hydrocodone-acetaminophen (98.9%). Adjusted logistic regression revealed a significantly increased odds of receiving an opioid prescription if in the non-block group (OR 3.01, 95% CI 1.95 to 4.68, p<0.001). Additionally, patients who did not receive a block were more likely to receive both higher doses (geometric mean ratio 1.54, 95% CI 1.31 to 1.81, p<0.001), and a greater number of doses (geometric mean ratio 1.87, 95% CI 1.50 to 2.33, p<0.001) compared to patients who did receive a nerve block. ## Discussion The use of regional anesthesia in pediatric IR for outpatient sclerotherapy for bone cysts, venous malformations, and lymphatic malformations was associated with a significant opioid-sparing effect that continued beyond the acute hospitalization into discharge. Enhanced Recovery After Surgery protocol development in IR would likely benefit from the early implementation of nerve block use.https://cassyni-user-files-prod.s3.amazonaws.com/3TxRDRT4QUyJiVb5uUrPMg https://cassyni.com/slides/outline/69YfbvSX7z3Pg1t45j8ZZ7 https://cassyni.com/events/69YfbvSX7z3Pg1t45j8ZZ7/abstract https://cassyni-user-files-prod.s3.amazonaws.com/FQ5VNKcmLyCYnJa7sdtJfg https://cassyni.com/events/69YfbvSX7z3Pg1t45j8ZZ7?videoPreview=1 Heat mitigation, climate change adaptation and solutions on urban health: sustainable zero-carbon solutions for the futurenohttps://cassyni.com/events/69YfbvSX7z3Pg1t45j8ZZ7?videoPreview=12022-10-27T09:00:00+00:004091.4ElsevierRecently, there has been interest in examining how urbanisation and population growth are significantly related to the role of engineers in preparing appropriate platforms and facilities for decarbonized vehicles, technologies, and building facilities for carbon footprint reduction. The stability of the tropical anthroposcape climate is under enormous strain from human activity, which threatens both the resilience of the ecosystem and public health.  The effects of climate change, such as the acceleration of warming trends, the amplification of environmental catastrophes, and the reappearance of infectious diseases, might be amplified in the near future due to rising rates of urbanisation and population expansion. In order to establish evidence-based adaptation and mitigation policies to enhance climate resilience across the world, environmental and public health organisations at all operational scales need to intentionally adjust their methodologies. Another important factor in improving public health's capacity for adaptation and response to extreme climatic events is mainstreaming behaviour modification into adaptation strategies connected to such disasters, along with infrastructure, technical, and policy improvements. To address the negative health effects of climate change, as well as to improve the effectiveness and sustainability of climate solutions, the identification and management of constraints and barriers to climate change adaptation in anticipation of existing public health strategies are equally essential. The Sustainable Development Goals (SDGs), which reaffirm the growing global concern for sustainable cities and communities, have sparked this interest. Scientists, engineers, and decision-makers have limited knowledge of the effects of climate change mitigation and adaptation. A zero carbon solution and developed decarbonized technology for adaptation and mitigation can significantly lessen the severity of local climate change. It is unknown how much these technologies contributed specifically. Therefore, it is difficult to develop and put into effect appropriate policies to mitigate the effects of climate change.  If necessary,  engineers can oversee the careful closure and repair of hazardous areas, as well as enhance passive structures, active transportation, and decarbonized technologies. This brings us together to discuss the role of engineers, scientists, health practitioners, governors, and decision-makers in creating environmentally friendly, sustainable, zero-carbon solutions for the future.https://cassyni-user-files-prod.s3.amazonaws.com/FQ5VNKcmLyCYnJa7sdtJfg https://cassyni.com/events/4AZXpNe1j6rpw5N95newJu/seminar/qa https://cassyni.com/slides/outline/4AZXpNe1j6rpw5N95newJu https://cassyni.com/events/4AZXpNe1j6rpw5N95newJu/abstract https://cassyni-user-files-prod.s3.amazonaws.com/82q3A7EdZ1NKnKyE13XM8i https://cassyni.com/events/4AZXpNe1j6rpw5N95newJu?videoPreview=1 The glowing fate of hot electronsnohttps://cassyni.com/events/4AZXpNe1j6rpw5N95newJu?videoPreview=12023-05-16T13:00:00+00:004189.56MetaMAT I will describe a new series of nanoscale components based on a reversible transduction between electron and a photon using optical gap antennas. Our concept provides a novel approach where the light source and the detector can be integrated into a single metallic nanostructure. At the core of the device is an atomic-scale tunnel gap whereby optical rectification, inelastic tunneling, and hot carriers can reciprocally mix photons and electrons with ultrafast conversion dynamics. We will discuss the peculiarity of the broadband spectrum emitted from the antenna feed by a decaying population of hot electrons. The source can be readily integrated to plasmonic and photonic waveguides. The co-integration of atomic-scale optical functional devices with an electronic transduction offers a disruptive solution to interface photons and electrons at this ultimate length scale. https://cassyni-user-files-prod.s3.amazonaws.com/82q3A7EdZ1NKnKyE13XM8i https://cassyni.com/slides/outline/G2WkXbP1u97iXXt5bHtvh3 https://cassyni.com/events/G2WkXbP1u97iXXt5bHtvh3/abstract https://cassyni-user-files-prod.s3.amazonaws.com/CUqwYA3ADovxccGcVWd7CS https://cassyni.com/events/G2WkXbP1u97iXXt5bHtvh3?videoPreview=1 Interaction of boundary layer instabilities and geometrical wall features: some recent work and ideas for next stepsnohttps://cassyni.com/events/G2WkXbP1u97iXXt5bHtvh3?videoPreview=12022-10-12T13:00:00+00:003060.96Department of AeronauticsBoundary layer instabilities are of paramount importance for the dynamics of transitional flows, themselves dominating drag production and efficiency of many relevant systems such as aircraft wings. However, in most real-life cases, aerodynamic surfaces are not smooth or geometrically perfect. Surface non-uniformities are inevitable due to debris, damages, and manufacturing features such as joints, panels, rivets etc. These geometrical features have a profound effect on boundary layer instabilities and transition. These effects are reviewed in this talk, based on recent experimental and numerical studies of our team. Expectedly, in most cases the effect of these features is detrimental, thus leading to anticipation of transition. However, we have discovered limited cases where roughness can actually lead to a delay of transition. These cases have revealed a wealth of fundamental interaction mechanisms, which can pave the way to passive flow control methods. Some next steps and ideas in moving forward will be shared.https://cassyni-user-files-prod.s3.amazonaws.com/CUqwYA3ADovxccGcVWd7CS https://cassyni.com/events/MTE4KfmVgmKDTUS1MZSrww/abstract https://cassyni-user-files-prod.s3.amazonaws.com/6iLhPVuDfXo9w5zB5tGomg https://cassyni.com/slides/outline/HzgpztEpcZSaRn8Shu4uR7 https://cassyni.com/events/HzgpztEpcZSaRn8Shu4uR7/abstract https://cassyni-user-files-prod.s3.amazonaws.com/PZQCDURusUjwKEmZ62pA2 https://cassyni.com/events/HzgpztEpcZSaRn8Shu4uR7?videoPreview=1 Recent developments and v5.2nohttps://cassyni.com/events/HzgpztEpcZSaRn8Shu4uR7?videoPreview=12022-09-13T12:35:00+00:001305.52NEKTAR++No abstracthttps://cassyni-user-files-prod.s3.amazonaws.com/PZQCDURusUjwKEmZ62pA2 https://cassyni.com/slides/outline/LTvrEJUSorD4nic1FayY93 https://cassyni.com/events/LTvrEJUSorD4nic1FayY93/abstract https://cassyni-user-files-prod.s3.amazonaws.com/9R6UCKji3ZUhX8P89tNCkW https://cassyni.com/events/LTvrEJUSorD4nic1FayY93?videoPreview=1 Studies of disturbance growth in transonic boundary layers over complex geometries using embedded DG simulationsnohttps://cassyni.com/events/LTvrEJUSorD4nic1FayY93?videoPreview=12022-09-15T10:30:00+00:001564.44NEKTAR++Laminar boundary layer natural transition for external flows is of particular interest in both the aeronautical industry and academia. The transitional process is dominated by the linear growth of disturbances, e.g., Tollmien–Schlichting waves and crossflow waves, and therefore a correct prediction on the development of the disturbances is necessary for a successful transitional analysis. Most conventional studies focused on the disturbances developing based on incompressible boundary layer flows over ideal, clean geometries. However, the physical settings for wider real applications are different for the flow compressibility and geometrical complexity. The compressibility stems from the transonic operational conditions, and for the real geometries the main source of the complexity is the existence of surface imperfections, which typically take the form of steps and gaps whose sizes are comparable with the boundary layer thickness. In the current study we therefore further extend the physical settings to transonic laminar boundary layer at realistic Reynolds numbers, and over wing sections with surface imperfections.https://cassyni-user-files-prod.s3.amazonaws.com/9R6UCKji3ZUhX8P89tNCkW https://cassyni.com/slides/outline/Urx81vUNGdd3x3xUKSJbMw https://cassyni.com/events/Urx81vUNGdd3x3xUKSJbMw/abstract https://cassyni-user-files-prod.s3.amazonaws.com/SAE3P7e37V6mafPV8zG9Q2 https://cassyni.com/events/Urx81vUNGdd3x3xUKSJbMw?videoPreview=1 The dynamics of super-absorbent hydrogelsnohttps://cassyni.com/events/Urx81vUNGdd3x3xUKSJbMw?videoPreview=12022-10-07T15:00:00+00:004027.48Journal of Fluid MechanicsSuper-absorbent polymers placed in water can form hydrogels with polymer fractions of less than 1% by volume, with the water molecules being adsorbed by the hydrophilic polymer to form an elastic material. They are used in disposable diapers, for soil remediation, for controlled drug delivery and as actuators in microfluidic devices. Hydrogels are also a component part of the xylem, through which water is transported upwards in trees. The water is not fixed in place but can flow through the porous polymer scaffold to drive swelling, drying and transpiration. We have developed a new mathematical approach to model super-absorbent hydrogels, which allows for strongly nonlinear swelling while remaining linear in deviatoric strains, in effect treating hydrogels as instantaneously incompressible, linear elastic materials with inhomogeneous elastic properties related to the differential swelling states. I will describe this model and illustrate its features by solving simple examples of swelling spheres and transpiration through cylinders, and by analysing different instabilities that can arise during swelling and drying. I will also introduce a hypothesis for a potential role of hydrogels in pumping water up very tall trees.https://cassyni-user-files-prod.s3.amazonaws.com/SAE3P7e37V6mafPV8zG9Q2 https://cassyni.com/events/XLC9FLhzTvPYJzS2s8DE5s/abstract https://cassyni-user-files-prod.s3.amazonaws.com/5ZmUtayp5QBB7oH3854B3k https://cassyni.com/events/TseuvZBKPiWuHJ8UDTqGZ3/abstract https://cassyni-user-files-prod.s3.amazonaws.com/KsxrXE9dfCsh3fSe7KP5G https://cassyni.com/events/TseuvZBKPiWuHJ8UDTqGZ3?videoPreview=1 Contextual learning of new meanings for familiar wordforms from reading and listening to stories (PhD Celebration)nohttps://cassyni.com/events/TseuvZBKPiWuHJ8UDTqGZ3?videoPreview=12023-03-03T03:10:00+00:001849.84Linguistics and Applied Language StudiesBoth first (L1) and second (L2) language speakers learn new meanings of known words through reading and listening. This learning results in changes in the mental lexicon, including adjustments to how existing (old) meanings are accessed. To investigate how the lexical-semantic space changes as a result of learning new meanings through encountering them multiple times in context, two studies were conducted. Two text-related factors were investigated: number of exposures (Study 1) and context variability (Study 2). In this seminar, I will detail how the two studies were conducted, share some of the main findings and provide suggestions for future research.https://cassyni-user-files-prod.s3.amazonaws.com/KsxrXE9dfCsh3fSe7KP5G https://cassyni.com/slides/outline/hHtUKtW8TAZkSRxLRv8g5 https://cassyni.com/events/hHtUKtW8TAZkSRxLRv8g5/abstract https://cassyni-user-files-prod.s3.amazonaws.com/UFyrq291ygTBgrtiJXHPDG https://cassyni.com/events/hHtUKtW8TAZkSRxLRv8g5?videoPreview=1 Multi-scale steady solutions representing classical and ultimate scaling in thermal convectionnohttps://cassyni.com/events/hHtUKtW8TAZkSRxLRv8g5?videoPreview=12021-05-28T15:00:00+00:001766.24Journal of Fluid MechanicsRayleigh–Bénard convection is one of the most canonical flows widely observed in nature and engineering applications. The effect of buoyancy on a flow is characterised by the Rayleigh number Ra, and the flow becomes turbulent eventually as Ra increases. One of the primary interests in convective turbulence is the scaling law of the Nusselt number Nu (dimensionless vertical heat flux) with Ra. A one-third power law for Nu with Ra, referred to as the 'classical' scaling, has been reported in many experiments and numerical simulations. On the other hand, a one-half power law, referred to as the 'ultimate' scaling, has not been observed yet in conventional Rayleigh–Bénard convection (buoyancy-driven convection between horizontal impermeable walls with a constant temperature difference). In this talk, I will first discuss a multi-scale steady solution in the conventional Rayleigh–Bénard convection. It is a three-dimensional steady solution to the Boussinesq equations, found using a homotopy from the wall-to-wall optimal transport solution (Motoki et al. 2018 J. Fluid Mech., 851, R4). The exact coherent thermal convection exhibits the classical scaling and reproduces structural and statistical properties of convective turbulence. Next, I will draw attention to thermal convection between permeable walls. The permeable wall is a simple model mimicking a Darcy-type porous wall (Jiménez et al. 2001 J. Fluid Mech. 442, 89-117). The wall permeability leads to the ultimate scaling, meaning that a wall heat flux being independent of thermal conductivity, although the heat transfer on the wall is dominated by thermal conduction. Finally, I will discuss the physical mechanisms of classical and ultimate scaling.https://cassyni-user-files-prod.s3.amazonaws.com/UFyrq291ygTBgrtiJXHPDG https://cassyni.com/slides/outline/E3VzdR4d6u1Re7fmJnUrpD https://cassyni.com/events/E3VzdR4d6u1Re7fmJnUrpD/abstract https://cassyni-user-files-prod.s3.amazonaws.com/DQfJKre5u76a9o7bYcnw58 https://cassyni.com/events/E3VzdR4d6u1Re7fmJnUrpD?videoPreview=1 Roton-Like Excitations in Metamaterialsnohttps://cassyni.com/events/E3VzdR4d6u1Re7fmJnUrpD?videoPreview=12022-07-04T06:20:00+00:001876.04ETOPIMWe review our recent theoretical and experimental work on mimicking the famous roton dispersion relation of superfluid helium in rationally designed metamaterials. This especially includes three-dimensional non-local elastic and acoustic metamaterials with tailored interactions among the metamaterial unit cells beyond the nearest neighbors.https://cassyni-user-files-prod.s3.amazonaws.com/DQfJKre5u76a9o7bYcnw58 https://cassyni.com/slides/outline/GWk1rqJFJBmv149KrUPVY9 https://cassyni.com/events/GWk1rqJFJBmv149KrUPVY9/abstract https://cassyni-user-files-prod.s3.amazonaws.com/gEaMzWV5829t2AY6m1KTL https://cassyni.com/events/GWk1rqJFJBmv149KrUPVY9?videoPreview=1 Creating Synthetic Spaces for Higher-order Topological Sound Transportnohttps://cassyni.com/events/GWk1rqJFJBmv149KrUPVY9?videoPreview=12022-07-05T10:00:00+00:001868.04ETOPIMModern technological advances allow for the study of systems with additional synthetic dimensions. Higher-order topological insulators in topological states of matters have been pursued in lower physical dimensions by exploiting synthetic dimensions with phase transitions. While synthetic dimensions can be rendered in the photonics and cold atomic gases, little to no work has been succeeded in acoustics because acoustic wave-guides cannot be weakly coupled in a continuous fashion. Here, we formulate the theoretical principles and manufacture acoustic crystals composed of arrays of acoustic cavities strongly coupled through modulated channels to evidence one-dimensional (1D) and two-dimensional (2D) dynamic topological pumpings. In particular,the higher-order topological edge-bulk-edge and corner-bulk-corner transport are physically illustrated in finite-sized acoustic structures. We delineate the generated 2D and four-dimensional (4D) quantum Hall effects by calculating first and second Chern numbers and physically demonstrate robustness against the geometrical imperfections. Synthetic dimensions could provide a powerful way for acoustic topological wave steering and open up a platform to explore any continuous orbit in higher-order topological matter in dimensions four and higher.https://cassyni-user-files-prod.s3.amazonaws.com/gEaMzWV5829t2AY6m1KTL https://cassyni.com/slides/outline/971xAabNiKUQF1xRJJms65 https://cassyni.com/events/971xAabNiKUQF1xRJJms65/abstract https://cassyni-user-files-prod.s3.amazonaws.com/ScPWoHrsnAXFKGV6WFHhnE https://cassyni.com/events/971xAabNiKUQF1xRJJms65?videoPreview=1 Analysis of the TE band structure in high contrast honeycomb photonic crystalsnohttps://cassyni.com/events/971xAabNiKUQF1xRJJms65?videoPreview=12022-07-07T09:30:00+00:001488.04ETOPIMIn this talk, we analyse the propagation of Transverse Electric (TE) waves in a two dimensional honeycomb photonic medium. This medium consists of an homogeneous bulk of fixed permittivity and an array of high permittivity dielectric inclusions centered at the vertices of a honeycomb lattice. In this high contrast regime, we perform a mathematical study of the band structure of the photonic crystal. We use analytical ideas, together with numerical simulations, to deduce detailed local information on the crossings of the dispersion surfaces with for e.g. the existence of Dirac points as well as global behavior of the bands over the full Brillouin zone. The results presented here come from the article [1] and are sum up in the conference paper [2]. Finally, we will discuss during this presentation the essential differences between this electromagnetic setting [1] and the quantum model of graphene analysed in [3].https://cassyni-user-files-prod.s3.amazonaws.com/ScPWoHrsnAXFKGV6WFHhnE https://cassyni.com/slides/outline/BaFyPzpzucEtbxRyqzgVp1 https://cassyni.com/events/BaFyPzpzucEtbxRyqzgVp1/abstract https://cassyni-user-files-prod.s3.amazonaws.com/YV6hbmzWBRsN9u9RJJR7k https://cassyni.com/events/BaFyPzpzucEtbxRyqzgVp1?videoPreview=1 Magneto-Optical Materials with Zero Net Magnetizationnohttps://cassyni.com/events/BaFyPzpzucEtbxRyqzgVp1?videoPreview=12022-07-08T13:20:00+00:001375.04ETOPIMThe key component of nonreciprocal devices, including microwave and optical isolators, circulators, and nonreciprocal phase shifters, is a magneto-optical material placed in an external magnetic field. This traditional approach involves the use of bulky magnets creating a relatively strong and nonuniform magnetic field inside and outside the magneto-optical component. Here we achieve the same nonreciprocal functionalities by using magneto-optical composite material with zero net magnetization and not requiring a bias magnetic field.https://cassyni-user-files-prod.s3.amazonaws.com/YV6hbmzWBRsN9u9RJJR7k https://cassyni.com/slides/outline/PvVhfiX1HR1Ue7NC6vBfam https://cassyni.com/events/PvVhfiX1HR1Ue7NC6vBfam/abstract https://cassyni-user-files-prod.s3.amazonaws.com/48nvCrmYem3TzuDB47us8a https://cassyni.com/events/PvVhfiX1HR1Ue7NC6vBfam?videoPreview=1 Discussion about the Glioblastoma Research Organization with its founder and director, Amber Barbachnohttps://cassyni.com/events/PvVhfiX1HR1Ue7NC6vBfam?videoPreview=12022-08-29T20:00:00+00:001884.12Journal of Neuro-OncologyNo abstracthttps://cassyni-user-files-prod.s3.amazonaws.com/48nvCrmYem3TzuDB47us8a https://cassyni.com/slides/outline/JVN4ACQETNvQFF7xW1BsbK https://cassyni.com/events/JVN4ACQETNvQFF7xW1BsbK/abstract https://cassyni-user-files-prod.s3.amazonaws.com/QgHEF4hTo7S79wQNHZajX4 https://cassyni.com/events/JVN4ACQETNvQFF7xW1BsbK?videoPreview=1 Affronting Ocean Models: Submesoscale Interactions between Fronts, Instabilities, and Wavesnohttps://cassyni.com/events/JVN4ACQETNvQFF7xW1BsbK?videoPreview=12020-05-29T15:00:00+00:003344.88Journal of Fluid MechanicsOcean fronts - sharp horizontal gradients in temperature, salinity, and density - are a key feature of the upper ocean that affect the transport of pollutants and the nature of near surface flows. I will highlight some of the recent modeling and theoretical work our group and collaborators have taken on to understand how fronts, frontal instabilities and turbulence, and surface waves interact. Traditional geophysical boundary layer theory neglects horizontal variations, and so is unable to capture frontal dynamics. Some consequences of these features found in large scale modeling and observations of oil, plastics and biological tracer dispersion; boundary layers; fluid energy cycling and dissipation statistics; and finally climate sensitivity will be elucidated.https://cassyni-user-files-prod.s3.amazonaws.com/QgHEF4hTo7S79wQNHZajX4 https://cassyni.com/slides/outline/UNL95sLjEXzj6m7z1ZxEjF https://cassyni.com/events/UNL95sLjEXzj6m7z1ZxEjF/abstract https://cassyni-user-files-prod.s3.amazonaws.com/NwG8ynDpdPmCsrSrWcB7mp https://cassyni.com/events/UNL95sLjEXzj6m7z1ZxEjF?videoPreview=1 A Probabilistic Logic Between LPP1 and LPP2nohttps://cassyni.com/events/UNL95sLjEXzj6m7z1ZxEjF?videoPreview=12022-12-14T15:00:00+00:003528.76Logica UniversalisAn extension of the propositional probability logic LPP2 given in Ognjanović et al. (Probability Logics. Probability-Based Formalization of Uncertain Reasoning, Theoretical Springer, Cham, Switzerland, 2016) that allows mixing of propositional formulas and probabilistic formulas is introduced. We describe the corresponding class of models, and we show that the problem of deciding satisfiability is in NP. We provide infinitary axiomatization for the logic and we prove that the axiomatization is sound and strongly complete.https://cassyni-user-files-prod.s3.amazonaws.com/NwG8ynDpdPmCsrSrWcB7mp https://cassyni.com/events/59rjujw4c1xybqC9Bm8G7o/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Mct8qweeqyznGhZVJSrJLN https://cassyni.com/slides/outline/EYBDnjE2wiVFTafH6tbpzR https://cassyni.com/events/EYBDnjE2wiVFTafH6tbpzR/abstract https://cassyni-user-files-prod.s3.amazonaws.com/M25aVNFB2X8buQZ1h6iFqG https://cassyni.com/events/EYBDnjE2wiVFTafH6tbpzR?videoPreview=1 Machine Learning for Partial Differential Equationsnohttps://cassyni.com/events/EYBDnjE2wiVFTafH6tbpzR?videoPreview=12021-03-04T16:00:00+00:003454.4DataSıgOur understanding and ability to compute the solutions to nonlinear partial differential equations has been strongly curtailed by our inability to effectively parameterize the inertial manifold of their solutions. I will discuss our ongoing efforts for using machine learning to advance the state of the art, both for developing a qualitative understanding of 'turbulent' solutions and for efficient computational approaches. We aim to learn parameterizations of the solutions that give more insight into the dynamics and/or increase computational efficiency. I will discuss our recent work using machine learning to develop models of the small scale behavior of spatio-temporal complex solutions, with the goal of maintaining accuracy albeit at a highly reduced computational cost relative to a full simulation.https://cassyni-user-files-prod.s3.amazonaws.com/M25aVNFB2X8buQZ1h6iFqG https://cassyni.com/slides/outline/F2ppqQsZPB3JTMCAhKtdFj https://cassyni.com/events/F2ppqQsZPB3JTMCAhKtdFj/abstract https://cassyni-user-files-prod.s3.amazonaws.com/HDpNajSgzxCd9m1E113Ban https://cassyni.com/events/F2ppqQsZPB3JTMCAhKtdFj?videoPreview=1 12 Labours Seminar Series (EP1): Pulmonary Hypertensionnohttps://cassyni.com/events/F2ppqQsZPB3JTMCAhKtdFj?videoPreview=12023-08-09T00:00:00+00:003565.72Auckland Bioengineering InstitutePulmonary hypertension (PH) is a debilitating progressive disease characterised by abnormally high pulmonary blood pressures, leading to heart failure and, eventually, death. 12 Labours’ Exemplar Project 1 is focused on improving the diagnosis and phenotyping of PH disease through patient-specific models that are carefully calibrated to clinical imaging and physiological measurements. The personalised digital models can be used to uncover new potential treatment strategies for PH disease management. Our initial studies have established a modelling workflow to evaluate response to treatment in a chronic thromboembolic PH patient cohort for whom surgical treatment is an option. Here we present some of the results of this pilot study, outline how this pipeline can be applied to other cardiovascular conditions, and future studies that will build on this work.https://cassyni-user-files-prod.s3.amazonaws.com/HDpNajSgzxCd9m1E113Ban https://cassyni.com/events/H1ayhvYyZApRSEEejXzYhB/seminar/qa https://cassyni.com/slides/outline/H1ayhvYyZApRSEEejXzYhB https://cassyni.com/events/H1ayhvYyZApRSEEejXzYhB/abstract https://cassyni-user-files-prod.s3.amazonaws.com/KYwpfaFJPcLP84gSE5Rzb8 https://cassyni.com/events/H1ayhvYyZApRSEEejXzYhB?videoPreview=1 te reo Māori loanword phonologynohttps://cassyni.com/events/H1ayhvYyZApRSEEejXzYhB?videoPreview=12024-03-15T03:10:00+00:002244.76Linguistics and Applied Language StudiesWhen words are borrowed into reo Māori speakers must make choices as to how deal with consonant clusters. Ray Harlow's classic chapter "Borrowing and its alternatives in Māori" sets out the basic choice between anapytyxis (insertion of a vowel) and consonant loss, but which words use which strategy; why; which vowels are inserted when anaptyxis is involved; and which consonants are lost in which environment has been little studied. This presentation summarizes the conclusions in the literature and extends them with reference to the loanword appendix in Willliams's Dictionary of the Māori Language.https://cassyni-user-files-prod.s3.amazonaws.com/KYwpfaFJPcLP84gSE5Rzb8 https://cassyni.com/events/D4Q9LTNn3WPGeZmyLRQW6H/abstract https://cassyni-user-files-prod.s3.amazonaws.com/UP9ReanotNUtH1vLudu3dG https://cassyni.com/events/Kyyp3Mi5SQp8mfivtFG4Ny/abstract https://cassyni-user-files-prod.s3.amazonaws.com/F8ZhtFjRZz4r3eSQ7joENz https://cassyni.com/events/7dpx7XZjGgpMmBn9ADSPFs/seminar/qa https://cassyni.com/slides/outline/7dpx7XZjGgpMmBn9ADSPFs https://cassyni.com/events/7dpx7XZjGgpMmBn9ADSPFs/abstract https://cassyni-user-files-prod.s3.amazonaws.com/McYbRqYAuSRjhUPvKwQjYz https://cassyni.com/events/7dpx7XZjGgpMmBn9ADSPFs?videoPreview=1 Learning the stochastic dynamics of biological matternohttps://cassyni.com/events/7dpx7XZjGgpMmBn9ADSPFs?videoPreview=12024-09-26T13:00:00+00:003499.0Journal of Biological PhysicsThe dynamics of biological systems, from proteins to cells to organisms, is complex and stochastic. To decipher their physical laws, we need to bridge between experimental observations and theoretical modeling. Thanks to progress in microscopy and tracking, there is today an abundance of experimental trajectories reflecting these dynamical laws. Inferring physical models from imperfect experimental data, however, is challenging and currently remains a bottleneck to data-driven biophysics. In this talk, I will present a set of tools developed to bridge this gap and permit robust and universal inference of stochastic dynamical models from experimental trajectories. These methods are rooted in an information-theoretical framework that quantifies how much can be inferred from trajectories that are short, partial and noisy. They permit the efficient inference of dynamical models for overdamped and underdamped Langevin systems, as well as the inference of entropy production rates. I finally present early applications of these techniques, as well as future research directions.https://cassyni-user-files-prod.s3.amazonaws.com/McYbRqYAuSRjhUPvKwQjYz https://cassyni.com/slides/outline/9cRNJG9q2X37ru4NXBJKgR https://cassyni.com/events/9cRNJG9q2X37ru4NXBJKgR/abstract https://cassyni-user-files-prod.s3.amazonaws.com/9VH7E2Y8vnvtXfQ1PNd8R4 https://cassyni.com/events/9cRNJG9q2X37ru4NXBJKgR?videoPreview=1 Why the patent system should look more like Indiana and less like Kentuckynohttps://cassyni.com/events/9cRNJG9q2X37ru4NXBJKgR?videoPreview=12017-08-03T10:00:00+00:00846.44 School of Public PolicyClarity and certainty in the patent system facilitate the market for technology and technological progress, which is the key driver of long run economic growth. Alan Marco, Chief Economist at the US Patent and Trademark Office, calls for greater certainty in the patent system by examining the story of the Other Land of Lincoln: the Lincoln family's move from Kentucky to Indiana. https://cassyni-user-files-prod.s3.amazonaws.com/9VH7E2Y8vnvtXfQ1PNd8R4 https://cassyni.com/events/SQVXz8fZMSnxN1LDebBPpq/seminar/qa https://cassyni.com/slides/outline/SQVXz8fZMSnxN1LDebBPpq https://cassyni.com/events/SQVXz8fZMSnxN1LDebBPpq/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Tq55oiM3V4Rp1fWfF5HcF8 https://cassyni.com/events/SQVXz8fZMSnxN1LDebBPpq?videoPreview=1 Empowering Women - Health, Sport, and Physical Activitynohttps://cassyni.com/events/SQVXz8fZMSnxN1LDebBPpq?videoPreview=12025-01-10T14:00:00+00:003821.0Women's HealthThe interplay between women's health, sport, and physical activity is essential for fostering healthier communities and promoting gender equity. Despite the recognized benefits of an active lifestyle, women often face unique barriers that impede their participation in sports and physical activities. This special collection aims to gather innovative research, critical reviews, and case studies that explore the multifaceted relationship between women's health and their engagement in sport and physical activity. By showcasing diverse perspectives, this collection will contribute to a deeper understanding of the challenges and opportunities in this domain.https://cassyni-user-files-prod.s3.amazonaws.com/Tq55oiM3V4Rp1fWfF5HcF8 https://cassyni.com/slides/outline/KVR5LZcDD33AsCLeH9cTg9 https://cassyni.com/events/KVR5LZcDD33AsCLeH9cTg9/abstract https://cassyni-user-files-prod.s3.amazonaws.com/YMxcz9xmxSyKt4WXu9iev2 https://cassyni.com/events/KVR5LZcDD33AsCLeH9cTg9?videoPreview=1 Controlling light with geometric symmetriesnohttps://cassyni.com/events/KVR5LZcDD33AsCLeH9cTg9?videoPreview=12024-11-08T14:00:00+00:002877.04UK Metamaterials NetworkLight is an electromagnetic wave defined by several degrees of freedom (DoF), including frequency, momentum, amplitude, phase, and polarization. Controlling these properties is a key need in a wide array of technologies. Nanophotonic devices called “metasurfaces” fill this need by structuring common materials (such as silicon, glass, and metals) at subwavelength scales (micrometer and smaller). Recently, “nonlocal metasurfaces” with strong light-matter interactions have emerged as a platform for customizing scattering from a thin film using both local responses (isolated to single nanostructures) and nonlocal responses (collective effects from many adjacent nanostructures). Such interactions can be customized at will—a sandbox for invention in a platform that is readily manufacturable. Our research aims to both (1) invent, design and develop new devices using novel and emerging physical phenomena and (2) apply these new tools to exciting applications. Starting from an array of uniform subwavelength structures, we introduce small geometric perturbations that break specific symmetries, imparting remarkable control to light point-by-point across the device—in some cases, “complete” control over the physically relevant DoF. The complex geometries of these devices are “written down” by equations rooted in group theory and perturbation theory, minimizing or eliminating the need for computationally expensive optimization. Applications include new methods for optical combiners in augmented reality systems, custom couplers in integrated photonics for communications systems, and controlling the directionality and polarization of thermal emission in surprising ways. https://cassyni-user-files-prod.s3.amazonaws.com/YMxcz9xmxSyKt4WXu9iev2 https://cassyni.com/slides/outline/XqdBVenLBUt2ksaTFWBBpH https://cassyni.com/events/XqdBVenLBUt2ksaTFWBBpH/abstract https://cassyni-user-files-prod.s3.amazonaws.com/HcmBBHCZtQ8yBZNf3mwvb8 https://cassyni.com/events/XqdBVenLBUt2ksaTFWBBpH?videoPreview=1 Leveraging Spatial Intelligence and Urban Analytics for Real Estate and Economic Planningnohttps://cassyni.com/events/XqdBVenLBUt2ksaTFWBBpH?videoPreview=12024-10-28T22:00:00+00:003924.64The University of Auckland Business SchoolIn today's evolving landscape of real estate and economic development, informed decision-making is crucial. Geographic Information Systems (GIS) have become indispensable technologies for professionals tackling the complexities of urban planning, economic growth, housing analysis, and real estate development. This seminar examines the role of GIS as a spatial intelligence tool, facilitating professionals to visualize, analyse, and interpret data within a geographical framework. By integrating GIS with urban analytics, stakeholders can uncover market trends, pinpoint investment opportunities, and optimize urban infrastructure design. These advancements promote sustainable development, increase economic returns, and cultivate resilient urban environments, aligning with Environmental, Social, and Governance (ESG) requirements.https://cassyni-user-files-prod.s3.amazonaws.com/HcmBBHCZtQ8yBZNf3mwvb8 https://cassyni.com/events/Su992pK5nuM1Mms7F2UC69/seminar/qa https://cassyni.com/slides/outline/Su992pK5nuM1Mms7F2UC69 https://cassyni.com/events/Su992pK5nuM1Mms7F2UC69/abstract https://cassyni-user-files-prod.s3.amazonaws.com/PWjScQyBiwkBNQMYE3RpZ4 https://cassyni.com/events/Su992pK5nuM1Mms7F2UC69?videoPreview=1 Evaluating digital cognitive assessment tools and their potential use in primary care for older adultsnohttps://cassyni.com/events/Su992pK5nuM1Mms7F2UC69?videoPreview=12025-01-09T21:00:00+00:003637.2Family MedicineLearning objectives: * Recognize the prevalence of neurodegenerative disease and importance of early diagnosis * Explore innovative tools for identifying cognitive decline and their potential impact on disease management * Learn where to go/resources/referrals and identify ways to help patients and caregivers understanding the diseasehttps://cassyni-user-files-prod.s3.amazonaws.com/PWjScQyBiwkBNQMYE3RpZ4 https://cassyni.com/events/2Cividxqr1f4CKaNiot6QV/seminar/qa https://cassyni.com/slides/outline/2Cividxqr1f4CKaNiot6QV https://cassyni.com/events/2Cividxqr1f4CKaNiot6QV/abstract https://cassyni-user-files-prod.s3.amazonaws.com/d256knS6DRhJhYScgxKGA https://cassyni.com/events/D4zDjgCPW5qXibQQLM7nMK/seminar/qa https://cassyni.com/slides/outline/D4zDjgCPW5qXibQQLM7nMK https://cassyni.com/events/D4zDjgCPW5qXibQQLM7nMK/abstract https://cassyni-user-files-prod.s3.amazonaws.com/VRDaLSyQ1HbYGGJCCzdBNe https://cassyni.com/events/D4zDjgCPW5qXibQQLM7nMK?videoPreview=1 Collective Cell Movements: From Organ Formation to Material Propertiesnohttps://cassyni.com/events/D4zDjgCPW5qXibQQLM7nMK?videoPreview=12024-11-14T15:00:00+00:004882.24Journal of Biological PhysicsCollective cell movements play a critical role in guiding embryonic development, wound repair and disease progression, such as cancer metastasis. The coordination of these movements is influenced by mechanical forces. Additionally, biological tissues exhibit characteristics of soft materials, capable of flowing and deforming, a characteristic thought to be essential for proper embryonic development. Tissue material properties can change drastically during embryonic development, reminiscent of rigidity transitions in physics. However, measuring the impact of transitions on cell behaviours or identifying how to control the transitions is challenging experimentally in developing animals. In this talk, I will discuss our research, focusing on developing computational and theoretical models to investigate the interplay between tissue material properties, cellular functions and tissue boundary formation, yielding testable predictions for various developmental processes.https://cassyni-user-files-prod.s3.amazonaws.com/VRDaLSyQ1HbYGGJCCzdBNe https://cassyni.com/events/NTLKjJ1FF9HXipZwY3XnrZ/seminar/qa https://cassyni.com/slides/outline/NTLKjJ1FF9HXipZwY3XnrZ https://cassyni.com/events/NTLKjJ1FF9HXipZwY3XnrZ/abstract https://cassyni-user-files-prod.s3.amazonaws.com/VACE4LRtexebTRxQM6uk2i https://cassyni.com/events/NTLKjJ1FF9HXipZwY3XnrZ?videoPreview=1 Pixels to Skeletons: Towards Internet-Scale Biomechanicsnohttps://cassyni.com/events/NTLKjJ1FF9HXipZwY3XnrZ?videoPreview=12024-12-10T03:00:00+00:003841.04The Auckland Bioengineering InstituteThe analysis of human performance and health is traditionally confined to laboratory settings, limiting analysis at scale and "in the wild". From an standard RGB image or a video, can we look inside the body to gain useful information about human health? I will describe our recent work on two fronts. The first focuses on inferring the internal structure of the body, including the bones, lean tissue, and adipose tissue from a single image of a person. To make progress, we construct novel datasets that pair external 3D shape with MRI and CT data of the inside of the body and train neural networks to predict the inside from the outside. The second focuses on moving motion capture out of the lab and into the world. I will show our latest work on accurately recovering 3D human kinematics from video. We estimate both the human's motion and the motion of the camera, enabling us to infer human movement in a global coordinate system with state-of-the-art accuracy.https://cassyni-user-files-prod.s3.amazonaws.com/VACE4LRtexebTRxQM6uk2i https://cassyni.com/slides/outline/Vs4PRYi7q1bNDQ6QVvPXGZ https://cassyni.com/events/Vs4PRYi7q1bNDQ6QVvPXGZ/abstract https://cassyni-user-files-prod.s3.amazonaws.com/TBJZufNFVfqrk2TjMgH7pr https://cassyni.com/events/Vs4PRYi7q1bNDQ6QVvPXGZ?videoPreview=1 Understanding the genetic basis of stomatal morphogenesis and functionnohttps://cassyni.com/events/Vs4PRYi7q1bNDQ6QVvPXGZ?videoPreview=12024-10-23T13:00:00+00:001484.2The New Phytologist FoundationEach formed by a pair of guard cells, stomata are microscopical pores that play fundamental roles in plant photosynthesis, water use efficiency and stress adaptation. The simple stomatal structure and specialised guard cell anatomy enable plants to respond and adapt to environmental changes rapidly. To identify genetic determinants involved in stomatal formation and maturation, we took advantage of forward genetic approaches and performed focused mutant screens. Here, we report the isolation and characterization of two mutants, lds1 and dsm1. LIPID DROPLETS AND STOMATA 1 (LDS1)/RABC1 (At1g43890) encodes a member of the Rab GTPase family that is involved in regulating lipid droplets (LD) dynamics. The expression of LDS1/RABC1 is coordinated with the different phases of stomatal development. RABC1 physically interacts with SEIPIN2/3, two orthologues of mammalian Seipin, which function in the formation of LD. Disruption of RABC1, RABC1GEF1, or SEIPIN2/3 resulted in aberrantly large LD, severe defects in guard cell vacuole morphology, stomatal movements. DEFORMED STOMATA 1 (DSM1) encodes COBRA-LIKE 7 (COBL7), a plant-specific glycosylphosphatidylinositol (GPI)-anchored protein. COBRA-LIKE 7 and its closest homologue, COBL8, are first enriched on the forming cell plates during cytokinesis, and then their subcellular distribution and abundance change are correlated with the progressive stages of stomatal pore formation. Furthermore, we demonstrated that COBL7 plays a predominant and functionally redundant role with COBL8 in stomatal formation through regulating cellulose deposition and ventral wall modification. Our work provides necessary insight into the regulatory mechanisms of stomatal morphogenesis and function in Arabidopsis. Keywords: stomatal morphogenesis, cellulose, lipid droplets, ventral wall modification, plant developmenthttps://cassyni-user-files-prod.s3.amazonaws.com/TBJZufNFVfqrk2TjMgH7pr https://cassyni.com/events/YLJQexwk2JMraLZy3cJ9zV/seminar/qa https://cassyni.com/slides/outline/YLJQexwk2JMraLZy3cJ9zV https://cassyni.com/events/YLJQexwk2JMraLZy3cJ9zV/abstract https://cassyni-user-files-prod.s3.amazonaws.com/RWtCgcbAQdgpg1Vp7RRb5p https://cassyni.com/events/YLJQexwk2JMraLZy3cJ9zV?videoPreview=1 Fostering Connections: Creating Engaged Editorial Boardsnohttps://cassyni.com/events/YLJQexwk2JMraLZy3cJ9zV?videoPreview=12025-01-23T09:00:00+00:002055.2Topics at the heart of our communityThe backbone of any successful journal is its Editorial Board. Join us this January as we discuss how you can build connections and enhance collaboration across your editorial team. You will also get a sneak peak of our exciting new online Community dedicated to you, our network of Editors and Editorial Board Members. It's a space for connection, discussion, and empowerment.https://cassyni-user-files-prod.s3.amazonaws.com/RWtCgcbAQdgpg1Vp7RRb5p https://cassyni.com/events/WMjcarsXfq5C2s5vJ2WVSm/seminar/qa https://cassyni.com/slides/outline/WMjcarsXfq5C2s5vJ2WVSm https://cassyni.com/events/WMjcarsXfq5C2s5vJ2WVSm/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Wn5pMHDvYXvSxWChTPnPwc https://cassyni.com/events/WMjcarsXfq5C2s5vJ2WVSm?videoPreview=1 Extreme seas, climate change and banking stability: A bottom-up temporospatial stress test in the context of domestic real estatenohttps://cassyni.com/events/WMjcarsXfq5C2s5vJ2WVSm?videoPreview=12025-02-10T22:00:00+00:003986.4SACLWe undertake a novel bottom-up temporospatial climate stress test of extreme seas (from storms) and rising sea levels hazards on real estate values and banking stability in New Zealand (NZ). The context is pertinent since NZ has a bank-based financial system, with 85% of household wealth and 60% bank assets concentrated in domestic real estate that is mainly located in coastal cities. We find that, despite low current exposure (<1.5% properties exposed to coastal inundation), exposure rises markedly as sea levels rise. Socio-economically disadvantaged suburbs face heightened risks, and these are served by smaller local banks with inferior ex-ante financial risk profiles. Critically, the market has failed to fully price present-day and future coastal flooding risk to real estate values. Depending on sea level rise scenarios, potential annual flood losses range from 5% to 16%, and could be higher for permanently inundated properties. Delayed climate transition has a multiplier effect on financial loss, and vertical land motion can exacerbate the effect of sea level rise. The climate stress test shows that banks face losses of between 2%-14% on their core capital values (CET1) depending on scenario, and the degree of losses vary across banks (CET1 of between 8%-14% in the most severe scenario). https://cassyni-user-files-prod.s3.amazonaws.com/Wn5pMHDvYXvSxWChTPnPwc https://cassyni.com/events/3giz5wwBy7Akq26HuTQq2D/abstract https://cassyni-user-files-prod.s3.amazonaws.com/4QfFvg63k95Hu9Pcsuk9Lz https://cassyni.com/events/G2w6F37JwZ1cihL6soyZAM/seminar/qa https://cassyni.com/slides/outline/G2w6F37JwZ1cihL6soyZAM https://cassyni.com/events/G2w6F37JwZ1cihL6soyZAM/abstract https://cassyni-user-files-prod.s3.amazonaws.com/A77wQqgAZ9Qzxjt9qsA5Jn https://cassyni.com/events/G2w6F37JwZ1cihL6soyZAM?videoPreview=1 Operation-aware Aerodynamic Shape Optimization for Fuel-efficient Aircraft Designnohttps://cassyni.com/events/G2w6F37JwZ1cihL6soyZAM?videoPreview=12025-05-08T12:00:00+00:003255.72Brahmal Vasudevan Institute for Sustainable AviationDesigning an aircraft that operates optimally under various flight conditions requires the consideration of flight operational data in the aircraft design process. In this talk, I will discuss the evolution of aerodynamic shape optimization formulation from a single-point optimization (with nominal assumption) to a data-driven, operation-aware multipoint one – and the challenges to achieve the latter. The results show that integrating comprehensive aerodynamic considerations under various flight conditions in the optimization problem formulation can produce a more robust aircraft with more consistent fuel-efficient performance.https://cassyni-user-files-prod.s3.amazonaws.com/A77wQqgAZ9Qzxjt9qsA5Jn https://cassyni.com/events/J1Z8YQDJ6kA6xtJjXLmwDX/abstract https://cassyni-user-files-prod.s3.amazonaws.com/7EEwtUDB7FnFweyA4cN9XU https://cassyni.com/events/TtXDU59nsuERpQJm2uYJMT/seminar/qa https://cassyni.com/slides/outline/TtXDU59nsuERpQJm2uYJMT https://cassyni.com/events/TtXDU59nsuERpQJm2uYJMT/abstract https://cassyni-user-files-prod.s3.amazonaws.com/PTxAAVADbLxotFDnJptLvi https://cassyni.com/events/TtXDU59nsuERpQJm2uYJMT?videoPreview=1 Spotlight On… Collections: The Benefits for Journals, Editors, and Authorsnohttps://cassyni.com/events/TtXDU59nsuERpQJm2uYJMT?videoPreview=12025-04-17T14:00:00+00:002799.28Topics at the heart of our communityCollections, also known as ‘special’ or ‘focus’ issues, have been around for decades to attract high quality submissions to a journal. In recent years, these issues have been rising in popularity. A 2023 survey of Springer Nature authors and readers (n=4809) revealed that 72% of authors submitted to a collection. Why is this? Join the conversation and find out why authors choose to submit to collections, why editors feel the experience positively contributed to journal development and how they raise journal impact. Image credit: [Zoshua Colah (Unsplash)](https://unsplash.com/photos/bookshelves-are-filled-with-colorful-books-in-a-library-3L3wWzhAOdY).https://cassyni-user-files-prod.s3.amazonaws.com/PTxAAVADbLxotFDnJptLvi https://cassyni.com/slides/outline/RRFa82QHHFYAdmNaHYoVid https://cassyni.com/events/RRFa82QHHFYAdmNaHYoVid/abstract https://cassyni-user-files-prod.s3.amazonaws.com/KFZPZsmRjfbKPmn9J8A3iN https://cassyni.com/events/RRFa82QHHFYAdmNaHYoVid?videoPreview=1 Beyond carbon: environmental feedbacks from terrestrial carbon dioxide removal strategiesnohttps://cassyni.com/events/RRFa82QHHFYAdmNaHYoVid?videoPreview=12024-08-12T12:00:00+00:001215.28The New Phytologist FoundationAs the impacts of climate change become more damaging, the need for ambitious mitigation strategies becomes more urgent. Enhancing the ability of the terrestrial biosphere to store carbon has great potential in terms of mitigation, but less attention has so far been given to evaluating potential unintended consequences on the Earth system. Using cutting-edge modelling and measurement techniques, the Val Martin group at Sheffield investigates the possible side-effects of forest expansion, enhanced rock weathering, and wetland restoration on processes from radiative forcing, to air quality, to water storage. I will present results from across our research programme, highlighting the need for extensive evaluation to ensure safe deployment of these strategies.https://cassyni-user-files-prod.s3.amazonaws.com/KFZPZsmRjfbKPmn9J8A3iN https://cassyni.com/slides/outline/DUxrXhZmpQGU5cjMmWCJH https://cassyni.com/events/DUxrXhZmpQGU5cjMmWCJH/abstract https://cassyni-user-files-prod.s3.amazonaws.com/HWQ4NzJGdfNhGnx6hdV2cn https://cassyni.com/events/DUxrXhZmpQGU5cjMmWCJH?videoPreview=1 High Fidelity (HiFi) is the high-quality production of sound, now using Flow360 CFDnohttps://cassyni.com/events/DUxrXhZmpQGU5cjMmWCJH?videoPreview=12024-12-06T17:00:00+00:002120.24JKW Symposium TeamIn this engaging presentation from the 2024 Jameson-Kim-Wang Symposium, Dr. Qiqi Wang, co-founder of Flexcompute and Associate Professor at the Massachusetts Institute of Technology (MIT) Department of Aeronautics and Astronautics, demonstrates how High Fidelity (HiFi) simulations are transforming the field of aeroacoustics using Flexcompute’s Flow360 Computational Fluid Dynamics (CFD) technology. Dr. Wang introduces a relatable example by simulating the sound produced by a flute—a purely aerodynamic instrument where the air itself generates vibrations. Through this demonstration, he showcases how Flow360 CFD can model and predict the pressure fluctuations and sound generation within the flute, providing a deeper understanding of the aerodynamics at play. By using Flow360, Dr. Wang explains how HiFi simulations—typically associated with high-quality sound production—can now be applied to accurately simulate and study acoustics in aerospace applications. Dr. Wang emphasizes the challenges of hardware innovation in contrast to software advancements, highlighting how complex and computationally intense these simulations can be. The session offers insights into the future of sound simulation in aerospace engineering, showcasing how cutting-edge CFD technology is pushing the boundaries of aeroacoustic modeling and optimization for next-generation designs.https://cassyni-user-files-prod.s3.amazonaws.com/HWQ4NzJGdfNhGnx6hdV2cn https://cassyni.com/events/iAC1qrycdt6HYcF9sdAUV/seminar/qa https://cassyni.com/slides/outline/iAC1qrycdt6HYcF9sdAUV https://cassyni.com/events/iAC1qrycdt6HYcF9sdAUV/abstract https://cassyni-user-files-prod.s3.amazonaws.com/SrQUoMTVrsbmgGEBrvP16W https://cassyni.com/events/iAC1qrycdt6HYcF9sdAUV?videoPreview=1 Author Insight on How to Publish Vectors of Human Disease Data with GBIF and GigaBytenohttps://cassyni.com/events/iAC1qrycdt6HYcF9sdAUV?videoPreview=12025-04-22T15:00:00+00:004328.92GigaScience PressTDR, the Special Programme for Research and Training in Tropical Diseases hosted at the World Health Organization (WHO), GBIF and GigaScience Press have just extended their third call for authors to submit Data Release papers on vectors of human disease for inclusion in a thematic series published in GigaByte Journal. Round three builds on the first two phases of the series, which mobilized more than 700,000 occurrence records and 890,000 specimens from more than 70 countries. This webinar provides insight into how to submit your work to the series, with some of the authors of previous submissions presenting examples the types of work that have been published so far. And giving their perspectives of how the process of publishing a data publication is, how they working with the supporting data helpdesk to share the data with GBIF, and the feedback they have received so far from publishing their data in this manner. After this we’ll get insight from the vectors task group and data helpdesk team on their experiences and tips on submitting vectors data to GBIF. Ending with an opportunity to ask questions talking to the series editors, authors and vectors task group to ask any questions about data publishing. https://cassyni-user-files-prod.s3.amazonaws.com/SrQUoMTVrsbmgGEBrvP16W https://cassyni.com/slides/outline/B6T3nCe4YyUbKbcksLGZSD https://cassyni.com/events/B6T3nCe4YyUbKbcksLGZSD/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Az1a4gQsVPPFw9DTFvaN9c https://cassyni.com/events/B6T3nCe4YyUbKbcksLGZSD?videoPreview=1 Disrupting the Definition of Scholarship: Advancing Your Career with Nontraditional Scholarshipnohttps://cassyni.com/events/B6T3nCe4YyUbKbcksLGZSD?videoPreview=12024-02-07T08:00:00+00:003732.0AAMCIn this webinar, Mara Becker, MD, MSCE, discusses the evolution of how nontraditional scholarship is “counted” toward career advancement in academic medicine and Pilar Ortega, MD, MGM, Teresa Chan, MD, MHPE, MBA, and Kimberly Manning, MD, draw from personal experience to discuss the innovative modes of scholarship development and dissemination that have furthered their work and careers. This webinar is part of the Scholarly Publishing Webinar Series, hosted by Academic Medicine and MedEdPORTAL. For more information on the complete series, see [aamc.org/publishingwebinar](https://www.aamc.org/about-us/mission-areas/medical-education/scholarly-publishing-webinar-series). https://cassyni-user-files-prod.s3.amazonaws.com/Az1a4gQsVPPFw9DTFvaN9c https://cassyni.com/slides/outline/MU6MsBjyAx2jzacJB19tkM https://cassyni.com/events/MU6MsBjyAx2jzacJB19tkM/abstract https://cassyni-user-files-prod.s3.amazonaws.com/5vg7KNqNzNJmgRV9AKGFen https://cassyni.com/events/MU6MsBjyAx2jzacJB19tkM?videoPreview=1 European Insurance in the Presence of Climate Change – Products, Regulation and Skillsnohttps://cassyni.com/events/MU6MsBjyAx2jzacJB19tkM?videoPreview=12025-01-16T05:00:00+00:001789.44Risk Sciences#### Research Insights: Rüdiger Kiesel ***[Risk Sciences](https://www.keaipublishing.com/en/journals/risk-sciences/)*** aims to foster diverse, multidisciplinary insights in risk sciences, bridging theory and practice through a series of academic activities. This talk is part of the "Research Insights" track of this series, presenting cutting-edge findings and methodologies, offering valuable perspectives to researchers and practitioners alike. The main research areas of Prof. Dr. Rüdiger Kiesel are the risk management for power utility companies, bank, and insurance companies, modeling of electricity markets, valuation and hedging of derivatives (interest-rate, credit- and energy-related), optimal portfolio allocation under frictions. This speech record is an excerpt from Rüdiger's keynote speech for the [Risk Sciences Colloquium – International Seminar on Climate Risks](https://www.keaipublishing.com/en/journals/risk-sciences/event/risk-sciences-colloquium-international-seminar-on-climate-risks/), to be held on January 16, 2025, in Seoul, South Korea.https://cassyni-user-files-prod.s3.amazonaws.com/5vg7KNqNzNJmgRV9AKGFen https://cassyni.com/events/LUo9mpSvJ2vbKpnJ52gZwT/abstract https://cassyni-user-files-prod.s3.amazonaws.com/2fF7D9Ua3mfQ9jkbGVL1Ga https://cassyni.com/events/UspRZSSqkpLaVA8m8t1dAM/abstract https://cassyni-user-files-prod.s3.amazonaws.com/4tAKvDtS2L9qgBabZQeNii https://cassyni.com/slides/outline/6eeEUgLE1DR7geKbAMLACd https://cassyni.com/events/6eeEUgLE1DR7geKbAMLACd/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Sy7aP2Cmds9JcS1on7YueN https://cassyni.com/events/6eeEUgLE1DR7geKbAMLACd?videoPreview=1 Fred Jevons Lecture - Equity for Women in Sciencenohttps://cassyni.com/events/6eeEUgLE1DR7geKbAMLACd?videoPreview=12023-03-23T13:00:00+00:005524.96 School of Public PolicyAt this Fred Jevons lecture Dr Cassidy Sugimoto will explore the gender gap in science and technology, and what can be done to address it. Equity for Women in Science If current trends continue, women and men will be equally represented in the field of biology in 2069. In physics, math, and engineering, women should not expect to reach parity for more than a century. The gender gap in science and technology is narrowing, but at a decidedly unimpressive pace. And even if parity is achievable, what about equity? This talk will present a large-scale empirical analysis of the global gender gap in science, providing strong evidence that the structures of scientific production and reward impede women’s career advancement. Cassidy Sugimoto and her co-author Vincent Larivière detail the evidence for this gap and outline possible solutions in their new book Equity for Women in Science, to be published by Harvard in March 2023. The evidence is drawn from publication and survey data and shows that women are systematically denied the chief currencies of scientific credit: publications and citations. The rising tide of collaboration only exacerbates disparities, with women unlikely to land coveted leadership positions or gain access to global networks. The findings are unequivocal: when published, men are positioned as key contributors and women are relegated to low-visibility technical roles. The talk will conclude with a discussion of how intersecting disparities in labour, reward, and resources contribute to cumulative disadvantages for the advancement of women in science and what might be done to mitigate this. Joining Cassidy on the panel will be Anna Scaife, Professor of Radio Astronomy, The University of Manchester and Dawn Edge, Professor Mental Health & Inclusivity, The University of Manchester.https://cassyni-user-files-prod.s3.amazonaws.com/Sy7aP2Cmds9JcS1on7YueN https://cassyni.com/events/VN3gtgN59rzmxgQ1Q4WC1T/abstract https://cassyni-user-files-prod.s3.amazonaws.com/GN6zFBAGfyac4rNj8YVtbG https://cassyni.com/events/5AH5dBfMeRrsnzeAUHCtb7/seminar/qa https://cassyni.com/slides/outline/5AH5dBfMeRrsnzeAUHCtb7 https://cassyni.com/events/5AH5dBfMeRrsnzeAUHCtb7/abstract https://cassyni-user-files-prod.s3.amazonaws.com/5wd81iLQXnQc3mVhcJNCbg https://cassyni.com/events/5AH5dBfMeRrsnzeAUHCtb7?videoPreview=1 Freezing of hydrogels: modelling cryosuction, deformation and ice growthnohttps://cassyni.com/events/5AH5dBfMeRrsnzeAUHCtb7?videoPreview=12025-06-18T09:00:00+00:003172.96Royal Society PublishingWhen hydrogels – soft, porous materials formed from cross-linked polymer chains surrounded by adsorbed water molecules – are brought below freezing temperatures, water does not freeze in place inside the pores of the gel scaffold, and is instead expelled out of the hydrogel, forming pure ice. The gel that is left behind deswells and, as a result, stresses build up, impacting the mechanical response of the gel, the pressure exerted on the ice, and the transport of water through the gel towards the freezing front (‘cryosuction’). In this talk, motivated by recent experiments carried out at ETH Zurich, I will show how mathematical models can give deep insight into the processes driving the formation of ice and deswelling of the hydrogel, both of which are inextricably linked. Understanding these processes firstly gives insight into the properties of the hydrogel itself – when a gel is frozen, eventually a steady state is reached wherein osmotic pressures exerted by the partially-dried hydrogel depress the liquidus temperature at the phase boundary sufficiently that no more ice can form. This is the basis for ‘gel-freezing osmometry’ and can be used to probe the micro-scale structure of hydrogels without seeking a sometimes-complex understanding of the polymer chains and their interactions with water molecules. Secondly, hydrogels provide excellent analogues for other deformable porous media as they are frozen, such as porous asphalt on road surfaces and soft fruits or even human organs. I will illustrate how continuum-mechanical models based on our recent ‘LENS’ (linear-elastic-nonlinear-swelling) approach can quantify the fluid flows, deformation and stress buildup inside squishy materials when they freeze, allowing us to mitigate any resulting damage through controlling the growth of large chunks of pure ice.https://cassyni-user-files-prod.s3.amazonaws.com/5wd81iLQXnQc3mVhcJNCbg https://cassyni.com/slides/outline/97tFi6ZrCWBvn88i7kUttV https://cassyni.com/events/97tFi6ZrCWBvn88i7kUttV/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Q4c6Y6Kvi5XrtqMnjfGiai https://cassyni.com/events/97tFi6ZrCWBvn88i7kUttV?videoPreview=1 Live Gut Microbiome: Cryopreservation and Assaysnohttps://cassyni.com/events/97tFi6ZrCWBvn88i7kUttV?videoPreview=12025-09-09T14:00:00+00:00732.72Microbiome Virtual International ForumThe gut microbiome plays a central role in host responses to dietary, pharmaceutical, and environmental exposures, yet capturing its functional activity ex vivo remains a major challenge. We developed RapidAIM, a high-throughput assay that maintains live human gut microbiomes in 96-well format, enabling systematic screening of the effects of xenobiotics, prebiotics, and nutritional compounds. RapidAIM preserves taxonomic diversity and functional activity, providing reproducible insights into compound–microbiome interactions and has been shown to reproduce effects observed in vivo. To support longitudinal and large-scale applications, we have established protocols for cryopreservation of live gut microbiomes, which maintain the composition, function, and metabolic output of the microbiome after storage. Together, these innovations provide a robust platform for precision microbiome research, enabling reproducible, scalable investigations of how interventions shape microbial ecology and function.https://cassyni-user-files-prod.s3.amazonaws.com/Q4c6Y6Kvi5XrtqMnjfGiai https://cassyni.com/slides/outline/JVnPse8XVnpJSQZynXGW4d https://cassyni.com/events/JVnPse8XVnpJSQZynXGW4d/abstract https://cassyni-user-files-prod.s3.amazonaws.com/WrpqFhgRjHx6BQbn7HszHk https://cassyni.com/events/JVnPse8XVnpJSQZynXGW4d?videoPreview=1 Plasma-surface interactions in non-equilibrium plasmas: a new scientific frontiernohttps://cassyni.com/events/JVnPse8XVnpJSQZynXGW4d?videoPreview=12025-04-17T15:00:00+00:003030.2Journal of Plasma PhysicsNon-equilibrium low temperature plasmas are an abundant source of reactive species at ambient temperatures and pressures. This unique capability enables several emerging applications including health, materials synthesis and energy security. All these applications are governed by interactions of non-equilibrium plasmas with complex interfaces. The strong nonlinear coupling between the plasma and the complex interface leads to complex interfacial interactions which remain not well understood and have a major impact on the plasma properties, impinging species fluxes and can even lead to self-organization. Atmospheric pressure sheaths and boundary layers have length scales of 100 μm or less leading to significant diagnostics challenges. These plasmas are also prone to instabilities introducing high spatial and temporal variations in plasma properties and dynamics. This presentation will highlight three important case studies of plasma interactions with complex interfaces: nanoparticles, viruses and plasma-liquid interactions. Insights in these areas rely on quantitative studies involving modeling and in situ diagnostics that allow identifying mechanisms. Image credit: [Michael Dziedzic (Unsplash)](https://unsplash.com/photos/close-up-photo-of-clear-glass-star-ornament-jeEsHg_5j10).https://cassyni-user-files-prod.s3.amazonaws.com/WrpqFhgRjHx6BQbn7HszHk https://cassyni.com/events/7dX6rbtyqidN9w7j1y7XK3/seminar/qa https://cassyni.com/slides/outline/7dX6rbtyqidN9w7j1y7XK3 https://cassyni.com/events/7dX6rbtyqidN9w7j1y7XK3/abstract https://cassyni-user-files-prod.s3.amazonaws.com/5bsYRCi87UuorL5CMzwtPx https://cassyni.com/events/7dX6rbtyqidN9w7j1y7XK3?videoPreview=1 AI for African Healthcare: Beyond Chatbots Toward Contextually Informed Innovationnohttps://cassyni.com/events/7dX6rbtyqidN9w7j1y7XK3?videoPreview=12025-07-11T10:00:00+00:003685.92None The development of artificial intelligence promises to enable leapfrogging similar to how mobile technology assisted places like Sub-Saharan Africa in advancing digital adoption. However, when we observe what has been developed in the Global North, this has mainly consisted of chatbots, voice assistants, and similar applications. Increasingly, the question becomes: how can we design this technology for the health of all patients in Africa? One prevailing view is that we do not need another chatbot for Africa. In this talk, we will discuss the current status of AI for healthcare globally, then narrow our focus to the African context. Specifically, we will examine opportunities within constraints of limited datasets and computing resources, while navigating the changing disease landscape to develop AI that is contextually informed, meaningful, and holds potential for reverse innovation. This seminar is run in conjunction with the Data Science for Social Impact Lab at the University of Pretoria. Image credit: [National Cancer Institute (Unsplash)](https://unsplash.com/photos/person-wearing-lavatory-gown-with-green-stethoscope-on-neck-using-phone-while-standing-L8tWZT4CcVQ).https://cassyni-user-files-prod.s3.amazonaws.com/5bsYRCi87UuorL5CMzwtPx https://cassyni.com/events/4AysXpNJmWkj8EpANJjZnD/seminar/qa https://cassyni.com/slides/outline/4AysXpNJmWkj8EpANJjZnD https://cassyni.com/events/4AysXpNJmWkj8EpANJjZnD/abstract https://cassyni-user-files-prod.s3.amazonaws.com/N2pqQgrVFYdHAgXSQeJL6z https://cassyni.com/events/4AysXpNJmWkj8EpANJjZnD?videoPreview=1 Can Formal Logic Make Pure Chance Intelligible? Ladrière on the Eschatological Horizon of Reasonnohttps://cassyni.com/events/4AysXpNJmWkj8EpANJjZnD?videoPreview=12025-05-28T14:00:00+00:004512.04Logica UniversalisCan formal logic make pure chance intelligible? This paper examines how pure chance, understood as what lies beyond probability and determination, both disrupts and extends formal reasoning. Drawing on Jean Ladrière, we explore how logic, despite its reliance on determinate structures, must engage with an irreducible indeterminacy that conditions its very operation. Pure chance serves as both the origin of logical structures-providing the space for determinations-and their unattainable horizon, toward which reason asymptotically moves. Through Ladrière’s concept of reducing purification, we analyze how logic progressively abstracts from determinations to approach pure existence. Examining five modes of abstraction, from individual objects to logic as a discipline, we show that this movement is inherently eschatological: logic strives toward totalization while never achieving full closure. Parallels with Gödel’s incompleteness theorems and Kant’s self-expanding reason reinforce that logic’s engagement with chance reflects a deeper structure of intelligibility, not a failure of formalization. Ultimately, we argue that hope (espérance) is inscribed in the structure of reason itself. Rather than resolving indeterminacy, logic participates in an intelligibility that always exceeds its grasp, revealing that reason’s fulfillment is always beyond reach, yet always already at work.https://cassyni-user-files-prod.s3.amazonaws.com/N2pqQgrVFYdHAgXSQeJL6z https://cassyni.com/events/F3FAYrbrRawCeWeByqyFj3/abstract https://cassyni-user-files-prod.s3.amazonaws.com/NfvS2vMEAAxmsRb7icCnZ4 https://cassyni.com/events/MxMFK4B5yMciHoLAdrUdWM/abstract https://cassyni-user-files-prod.s3.amazonaws.com/TsTTd9KUbPNJjq1EPkzzTY https://cassyni.com/slides/outline/QRbGYUQiAePCejojBYPGEH https://cassyni.com/events/QRbGYUQiAePCejojBYPGEH/abstract https://cassyni-user-files-prod.s3.amazonaws.com/7PC9A2cYBSjyhFnTiQEf6E https://cassyni.com/events/QRbGYUQiAePCejojBYPGEH?videoPreview=1 AI Realities for Academic Librariesnohttps://cassyni.com/events/QRbGYUQiAePCejojBYPGEH?videoPreview=12025-07-09T13:00:00+00:002348.72Part of the nonprofit Annual Reviews organizationExploring the transformative impact of artificial intelligence on research, discovery, and library services Image credit: [Florian Wehde (Unsplash)](https://unsplash.com/photos/city-buildings-near-body-of-water-during-daytime-1uWanmgkd5g).https://cassyni-user-files-prod.s3.amazonaws.com/7PC9A2cYBSjyhFnTiQEf6E https://cassyni.com/slides/outline/C5PAPPEbCCYPSHL98HiGNR https://cassyni.com/events/C5PAPPEbCCYPSHL98HiGNR/abstract https://cassyni-user-files-prod.s3.amazonaws.com/PowNubsERqS7wqHQ18AAHc https://cassyni.com/events/C5PAPPEbCCYPSHL98HiGNR?videoPreview=1 Digital Transformationnohttps://cassyni.com/events/C5PAPPEbCCYPSHL98HiGNR?videoPreview=12020-11-13T00:00:00+00:003996.24Business SchoolDigital transformation is critically important for businesses navigating unprecedented disruption and technological commoditization, a process significantly accelerated by global events like COVID-19. It is understood not merely as the adoption of new technologies, but as a strategic imperative to redefine business models and enhance human potential, creating significant competitive advantages. A core tenet is prioritizing "effectiveness" (doing the right thing) by aligning technology with core business strategy and customer value propositions, before focusing on "efficiency" (doing things rightly). Examples from diverse industries illustrate this approach. In retail, the pandemic spurred explosive growth in online shopping, with one company reporting 200,000 new registrations. The construction sector achieved 90-95% reductions in BIM modeling time through AI-driven automation and developed new predictive, alert-based service models. In consumer electronics, the shift is from single hardware manufacturing to integrated IoT ecosystems, leveraging platforms for data flow, expanded service offerings, and improved supply chain efficiency. Key to successful transformation are strategic leadership commitment, fostering a growth mindset, and actively engaging and upskilling existing employees. The evolving role of IT, encompassing internal development and strategic decision-making, along with forming partnerships and alliances, are crucial enablers for organizations of all sizes.https://cassyni-user-files-prod.s3.amazonaws.com/PowNubsERqS7wqHQ18AAHc https://cassyni.com/events/NT2UUNLVpB6Y7GKgRxbbgZ/abstract https://cassyni-user-files-prod.s3.amazonaws.com/3AbVFDnnstjbCfvV9U1zBg https://cassyni.com/events/2h6Jd2TWFrwtQEKdQq4sQh/seminar/qa https://cassyni.com/slides/outline/2h6Jd2TWFrwtQEKdQq4sQh https://cassyni.com/events/2h6Jd2TWFrwtQEKdQq4sQh/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Rc3XqBtk3udLYT5J8CCqXC https://cassyni.com/events/2h6Jd2TWFrwtQEKdQq4sQh?videoPreview=1 Studying network of symmetric periodic orbit families of the Hill problem via symplectic invariants, Extension of the creep tide theory to exoplanet systems with high stellar obliquitynohttps://cassyni.com/events/2h6Jd2TWFrwtQEKdQq4sQh?videoPreview=12025-09-12T13:00:00+00:004406.08Celestial Mechanics and Dynamical AstronomyThis seminar presents two distinct advances in celestial mechanics and exoplanetary dynamics. The first study investigates the network of symmetric periodic orbit families in the Hill problem, a fundamental model in celestial mechanics describing the motion near a small body perturbed by a larger primary. By employing symplectic invariants—specifically the Conley–Zehnder index, Krein signature, and Euler characteristic—the analysis elucidates the bifurcation structure and interaction mechanisms among basic families of periodic orbits with maximal symmetries. The approach reveals how spatial periodic orbit families connect planar families through covering numbers and symmetry-breaking bifurcations, providing a systematic framework to understand the complex topology of the phase space. Key findings include the identification of stable and unstable branches, the role of collisional orbits, and the matching of symplectic indices at bifurcation points, which clarify the genealogy of orbit families and their transitions under perturbations. The second study extends the creep tide theory—a hydrodynamical model describing tidal deformation and dissipation—to three-dimensional configurations relevant for exoplanetary systems with high stellar obliquity. The model incorporates the coupled evolution of orbital elements, rotational dynamics, and time-dependent ellipsoidal deformations of both bodies, resulting in a stiff system of 22 differential equations solved numerically. Applications to systems such as CoRoT-3 demonstrate the dynamic evolution of stellar and planetary spin orientations, tidal lags, and orbital decay, highlighting phenomena like stellar spin braking and planetary obliquity damping. Recent improvements include analytical solutions reducing stiffness and enabling long-term integrations, revealing departures from spin-orbit synchronization and conservation of volume during deformation. This extension provides a robust framework for modeling tidal interactions in misaligned star-planet systems, with implications for understanding spin evolution and orbital dynamics in exoplanetary environments.https://cassyni-user-files-prod.s3.amazonaws.com/Rc3XqBtk3udLYT5J8CCqXC https://cassyni.com/events/F2BWCw2B7sjb3wWBRZRov5/seminar/qa https://cassyni.com/slides/outline/F2BWCw2B7sjb3wWBRZRov5 https://cassyni.com/events/F2BWCw2B7sjb3wWBRZRov5/abstract https://cassyni-user-files-prod.s3.amazonaws.com/LaakY8WofDe3R1hAS6gmve https://cassyni.com/events/F2BWCw2B7sjb3wWBRZRov5?videoPreview=1 NWL Kidney care update 2025nohttps://cassyni.com/events/F2BWCw2B7sjb3wWBRZRov5?videoPreview=12025-10-14T08:15:00+00:00873.44North West London Kidney CareThe North West London (NWL) kidney care update outlines ongoing efforts to reduce morbidity and mortality associated with chronic kidney disease (CKD) through integrated primary and secondary care initiatives across a population of approximately 2.1–2.3 million. The renal service operates a hub-and-spoke model with extensive outpatient clinics, transplantation, and dialysis services. Key interventions include the CKD Shared Care program, a virtual clinic for streamlined referral triage reducing wait times to under 4 days, and the CKD e-advice service facilitating rapid consultant input. Educational initiatives such as the “Know Your Kidneys” webinar have engaged over 850 patients to enhance disease understanding and self-management. The DiscoverNOW project represents a data-driven transformation integrating diagnostic coding, automated alerts, and management templates within primary care electronic systems to improve detection and care pathways. Recent data demonstrate significant improvements in CKD coding accuracy (reducing uncoded cases from 25% to 10% within one year), increased monitoring rates for kidney function (from 90.7% to 92.9%) and urine albumin-to-creatinine ratio (from ~50% to ~70%), and stable but high use of renin-angiotensin system inhibitors (76%). Despite these advances, CKD prevalence in NWL (2.5%) remains lower than national estimates (4.4%), highlighting underdiagnosis and the presence of “unknown unknowns.” Community outreach targeting high-risk and ethnically diverse populations revealed substantial albuminuria prevalence (41%), underscoring ongoing challenges in early detection and equitable access. These findings emphasize the need for continued integrated care, enhanced screening, and targeted community engagement to improve CKD outcomes in NWL.https://cassyni-user-files-prod.s3.amazonaws.com/LaakY8WofDe3R1hAS6gmve https://cassyni.com/slides/outline/2CR5TiJ6R3U4amL7ciwuEV https://cassyni.com/events/2CR5TiJ6R3U4amL7ciwuEV/abstract https://cassyni-user-files-prod.s3.amazonaws.com/DJvBKax5sb1rLDPw45ASPQ https://cassyni.com/events/2CR5TiJ6R3U4amL7ciwuEV?videoPreview=1 Dynamic Return and Star-Shaped Risk Measures via BSDEsnohttps://cassyni.com/events/2CR5TiJ6R3U4amL7ciwuEV?videoPreview=12025-07-06T11:00:00+00:001310.76Risk SciencesThis paper establishes characterization results for dynamic return and star-shaped risk measures induced via backward stochastic differential equations (BSDEs). We first characterize a general family of static star-shaped functionals in a locally convex Fréchet lattice. Next, employing the Pasch-Hausdorff envelope, we build a suitable family of convex drivers of BSDEs inducing a corresponding family of dynamic convex risk measures of which the dynamic return and star-shaped risk measures emerge as the essential minimum. Furthermore, we prove that if the set of star-shaped supersolutions of a BSDE is not empty, then there exists, for each terminal condition, at least one convex BSDE with a non-empty set of supersolutions, yielding the minimal star-shaped supersolution. We illustrate our theoretical results in a few examples and demonstrate their usefulness in two applications, to capital allocation and portfolio choice. This speech record is from Roger's keynote speech for [2025 International Workshop on Risk Sharing (IWRS) ](https://www.keaipublishing.com/en/journals/risk-sciences/event/2025-international-workshop-on-risk-sharing-iwrs/) , to be held on July 6-7, 2025, in Beijing, China. [Risk Sciences](https://www.keaipublishing.com/en/journals/risk-sciences/) aims to foster diverse, multidisciplinary insights in risk sciences, bridging theory and practice through a series of academic activities. This talk is part of the "Research Insights" track of this series, presenting cutting-edge findings and methodologies, offering valuable perspectives to researchers and practitioners alike. https://cassyni-user-files-prod.s3.amazonaws.com/DJvBKax5sb1rLDPw45ASPQ https://cassyni.com/slides/outline/4ff6h8XicLEYwhogAQrXxR https://cassyni.com/events/4ff6h8XicLEYwhogAQrXxR/abstract https://cassyni-user-files-prod.s3.amazonaws.com/GhcDhqjgTgxGxsxNDrX1Y https://cassyni.com/events/4ff6h8XicLEYwhogAQrXxR?videoPreview=1 Fractality, Kirigami and patterns architectures for bioinspired metamaterialsnohttps://cassyni.com/events/4ff6h8XicLEYwhogAQrXxR?videoPreview=12022-01-18T13:00:00+00:003227.8UK Metamaterials NetworkThis seminar explores the integration of fractal geometries, Kirigami-inspired cutting patterns, and hierarchical architectures in the design of bioinspired mechanical metamaterials. Emphasizing mechanical metamaterials with unusual properties such as negative Poisson’s ratio and tunable stiffness, the analysis highlights fractal-based configurations including nested perforated patterns and chiral fractal cells. These architectures are fabricated via additive manufacturing and laser cutting, enabling hierarchical and gradient designs. Key findings demonstrate that hierarchical fractal Kirigami structures exhibit exotic auxetic behavior and enhanced wave propagation control, with multiple band gaps emerging at increasing fractal orders. Chiral fractal metamaterials show exponential variation of mechanical properties with fractal order and maintain consistent energy dissipation characteristics under cyclic bending, supported by finite element modeling and experimental validation. Acoustic performance assessments reveal that fractal and coiled cavity metamaterials with equal cavity volumes yield similar sound absorption, governed primarily by cavity length rather than fractality per se. Natural fractality is evidenced in cactus fibers, whose tree-like microstructure exhibits unusually high bending-to-axial stiffness ratios, attributed to multi-scale cellular arrangements. Additionally, fractal surface roughness influences contact stiffness and friction, following power-law relationships that affect energy dissipation under dynamic loading. These insights underscore the potential of fractal and Kirigami-inspired architectures to tailor mechanical, acoustic, and dissipative properties in metamaterials, suggesting avenues for advanced multifunctional designs and bioinspired structural optimization.https://cassyni-user-files-prod.s3.amazonaws.com/GhcDhqjgTgxGxsxNDrX1Y https://cassyni.com/slides/outline/D4gNUkXe57eY73A9EGBbBK https://cassyni.com/events/D4gNUkXe57eY73A9EGBbBK/abstract https://cassyni-user-files-prod.s3.amazonaws.com/U7X8c2gWZXA1H5n2TXTY2S https://cassyni.com/events/D4gNUkXe57eY73A9EGBbBK?videoPreview=1 How to Transform your Business to a ChatGPT Centrenohttps://cassyni.com/events/D4gNUkXe57eY73A9EGBbBK?videoPreview=12024-03-20T00:00:00+00:003539.76Business SchoolLifewood, a global enterprise focused on AI and data products, initiated a comprehensive business transformation in 2022 to integrate generative AI, primarily GPT and Gemini, across its worldwide operations. This strategic shift aimed to significantly enhance efficiency and revolutionize customer engagement. The approach commenced with a robust training program, consisting of 60 courses, delivered to over 120 global managers to cultivate foundational AI knowledge and a culture of innovation. Throughout 2023, seven dedicated GPT centers were established internationally, embedding generative AI methodologies into diverse departments including IT, HR, marketing, and software development. Tools such as DALL·E, Microsoft Copilot, and GitHub Copilot were leveraged for tasks from data analysis to design and automated scripting. Cross-cultural communication was streamlined using multi-language transcription and automated meeting summaries, generated within 50 seconds. A GPT ticket logging system, recording over 1000 implementations by more than 80 staff, monitored progress and linked performance to KPIs. Key findings indicate substantial productivity gains, with an eightfold increase in frontend code shipment, a sixfold rise in backend code, and a fourfold acceleration in database management. DevOps and security scripting became largely LLM-generated, while design innovation was transformed by DALL·E and GPT for rapid visual creation and wireframe testing. Overall, an average 8 to 10-fold increase in software development productivity was achieved. These results demonstrate how strategic generative AI integration, supported by widespread training and systematic implementation, can drive profound operational enhancements and foster a significant competitive advantage.https://cassyni-user-files-prod.s3.amazonaws.com/U7X8c2gWZXA1H5n2TXTY2S https://cassyni.com/events/Nwg5X3z2Fdeb72ra2PtPws/seminar/qa https://cassyni.com/slides/outline/Nwg5X3z2Fdeb72ra2PtPws https://cassyni.com/events/Nwg5X3z2Fdeb72ra2PtPws/abstract https://cassyni-user-files-prod.s3.amazonaws.com/AMatiGQBfXJDqjdavn5pAi https://cassyni.com/events/Nwg5X3z2Fdeb72ra2PtPws?videoPreview=1 Sharing Impactful Work of Applied, Collaborative Statisticiansnohttps://cassyni.com/events/Nwg5X3z2Fdeb72ra2PtPws?videoPreview=12025-10-08T15:00:00+00:004099.52Journal of Statistical Theory and PracticeAvenues for disseminating work by applied and collaborative statisticians to statistical audiences are extremely limited. Methodological advances made in the course of effectively executing applied work often fail to reach an audience of other practicing statisticians. In this webinar, we discuss questions posed and elaborate on our responses in the manuscript ‘Where can we share the impactful work of applied, collaborative statisticians?’ Our panel consists of members of the professional community in academia, government, industry, and independent statistical consulting. We highlight key challenges and opportunities that frame our opinions and conclude with recommendations that are possible for the dissemination of impactful work by applied, practicing statisticians.https://cassyni-user-files-prod.s3.amazonaws.com/AMatiGQBfXJDqjdavn5pAi https://cassyni.com/slides/outline/HWYS1XsFRbZWiAcLRUtbxR https://cassyni.com/events/HWYS1XsFRbZWiAcLRUtbxR/abstract https://cassyni-user-files-prod.s3.amazonaws.com/FGj9CiwxQtodG2huhoSTYi https://cassyni.com/events/HWYS1XsFRbZWiAcLRUtbxR?videoPreview=1 Guiding stress: From pentamodes to cable webs and masonry structuresnohttps://cassyni.com/events/HWYS1XsFRbZWiAcLRUtbxR?videoPreview=12025-06-16T07:00:00+00:001561.2ETOPIMPentamode materials are a class of materials that are useful for guiding stress. In particular, they have been proposed for acoustic cloaking by guiding stress around objects and have been physically constructed. A key feature of pentamode materials is that each vertex in the material is the junction of 4 double cone elements. Thus, the tension in one element determines the tension in the other elements, and by extension uniquely determines the stress in the entire metamaterial. Here we show how this key feature can be extended to discrete wire networks, supporting forces at the terminal nodes and which may have internal nodes where no forces are applied. In usual wire or cable networks, such as in a bridge or bicycle wheel, one distributes the forces by adjusting the tension in the wires. Here our discrete networks provide an alternative way of distributing the forces through the geometry of the network. In particular, the network can be chosen so it is uniloadable, i.e. supports only one set of forces at the terminal nodes. Such uniloadable networks provide the natural generalization of pentamode materials to discrete networks. We extend such a problem to compression-only 'strut nets' subjected to fixed and reactive nodal loads. These systems provide discrete element models of masonry bodies. In particular, we solve the arch problem where one wants the strut net to avoid a given set of obstacles and also allow some of the forces to be reactive ones. This is joint work with Ada Amendola, Guy Bouchitte, Andrej Cherkaev, Antonio Fortunato, Fernando Fraternali, Ornella Mattei, and Pierre Seppecher.https://cassyni-user-files-prod.s3.amazonaws.com/FGj9CiwxQtodG2huhoSTYi https://cassyni.com/events/VrkYAd3NQ3QNbqr9PqTL6Z/abstract https://cassyni-user-files-prod.s3.amazonaws.com/9bGhAs1RN8SW2fp7r7rQHU https://cassyni.com/slides/outline/YKzZQ3GzbLArxnKhwXMxpV https://cassyni.com/events/YKzZQ3GzbLArxnKhwXMxpV/abstract https://cassyni-user-files-prod.s3.amazonaws.com/AaHtzENkq2dxmUCgkKYmLA https://cassyni.com/events/YKzZQ3GzbLArxnKhwXMxpV?videoPreview=1 A geometric phase for diffraction of scalar wavesnohttps://cassyni.com/events/YKzZQ3GzbLArxnKhwXMxpV?videoPreview=12025-06-19T01:00:00+00:001236.2ETOPIM1. Introduction: geometric phases In 1984, Berry showed that the phase of waves evolves not just dynamically, but also via adiabatic cyclic transformations of the system [1]. Famously, such an effect in polarization optics was demonstrated by Pancharatnam in 1955 [2], predating Berry’s generalized description, now often called the “Pancharatnam-Berry” or “PB” phase. It has had profound impacts on applied science and technologies, especially metasurface optics [3]. Here, we show that another geometric phase predated Berry’s description: the detour phase, observed and used in diffractive optics yet conventionally associated with propagation (a dynamic phase). The term was coined by Brown and Lohmann in 1966 [4], and the computer-generated holography community, and more recently the metasurface community, has leveraged it ever since to control the scattering of light. To our knowledge, identification as a geometric phase has eluded the scientific community, likely due to confusion stemming from dispersion. We demonstrate the geometric nature of the detour phase, establishing its topologically nontrivial nature. We clarify that the detour phase (1) arises from nontransitive transport on a Bloch sphere, associated with Berry curvature; (2) has a geometric component with no dispersion; (3) is a scalar effect (polarization agnostic); (4) can spatially manipulate phase without a geometric discontinuity (impossible with propagation phases); and (5) recontextualizes diffraction observed in many conventional devices. We further argue that the detour phase is generic to diffraction and demonstrate its presence in many systems, including aperiodic gratings and nonlocal metasurfaces. 2. Results Figure 1 directly compares a simple triangular grating (a-d) to a conventional PB phase metasurface (e-h) (as implemented in Ref. [5]). In both systems, the geometries (a,e) are designed to manipulate coupling between two states; leftward and rightward plane waves for the grating, and left-hand and right-hand circular polarization for the metasurface. Linear combinations of these states are placed on a Bloch sphere (b), which is the Poincare sphere in the case of polarization (f). In a suitably defined 2D parameter space defined by two geometrical parameters d1 and d2 (c,g), the amplitude and phase of the converted states form a topological feature, i.e., a phase singularity at the origin (d,h). This feature is a hallmark of geometric phases: cyclic evolution of the parameter around the singularity returns to the starting geometry having picked up an integer multiple of 2π.https://cassyni-user-files-prod.s3.amazonaws.com/AaHtzENkq2dxmUCgkKYmLA https://cassyni.com/slides/outline/QvGVhna81TsMCk8oPMkLNR https://cassyni.com/events/QvGVhna81TsMCk8oPMkLNR/abstract https://cassyni-user-files-prod.s3.amazonaws.com/6sRs972KY6UrpJPZbyYz14 https://cassyni.com/events/QvGVhna81TsMCk8oPMkLNR?videoPreview=1 Design and scaling laws for multifunctional grating couplersnohttps://cassyni.com/events/QvGVhna81TsMCk8oPMkLNR?videoPreview=12025-06-18T23:00:00+00:00563.88ETOPIMThe design of multifunctional grating couplers is critical for advancing integrated photonic systems, particularly in applications such as wafer alignment in chip manufacturing, where multiple input modes at various frequencies must be coupled efficiently on a single device. This study develops fundamental design principles and scaling laws for such multifunctional grating couplers, addressing the challenge of avoiding undesired coupling that arises when combining multiple periodic patterns for different frequencies or modes. By analyzing band diagrams and phase-matching conditions, it is shown that undesired couplings can be suppressed if these correspond to evanescent modes, a condition strongly influenced by the refractive index of the waveguide environment. The refractive index sets limits on the number of frequencies that can be coupled simultaneously; for example, a refractive index of 4 allows coupling of up to five frequencies without significant undesired coupling. For more general multifunctionality, the study demonstrates that multilayered devices are necessary, with the number of layers required equal to the number of functions to be coupled, enabling destructive interference to cancel undesired modes. Computational inverse design confirms these theoretical predictions, showing that high coupling efficiency demands at least as many layers as functions and that device thickness scales linearly with both the number of functions and the minimum wavelength. These findings establish a comprehensive framework for designing compact, efficient multifunctional grating couplers, elucidating the fundamental physical trade-offs and guiding future photonic integration efforts.https://cassyni-user-files-prod.s3.amazonaws.com/6sRs972KY6UrpJPZbyYz14 https://cassyni.com/slides/outline/TPWWwCokCkdqZgcMw3ey6M https://cassyni.com/events/TPWWwCokCkdqZgcMw3ey6M/abstract https://cassyni-user-files-prod.s3.amazonaws.com/C7jKYgVxsujbrm1aXk7kuk https://cassyni.com/events/TPWWwCokCkdqZgcMw3ey6M?videoPreview=1 A study of a generalized (3+1)-dimensional Kadomtsev- Petviashvili Benjamin-Bona-Mahony equation with power law nonlinearitynohttps://cassyni.com/events/TPWWwCokCkdqZgcMw3ey6M?videoPreview=12025-06-23T08:00:00+00:001010.04NODYSIn this talk we study a generalized (3+1)-dimensional Kadomtsev-Petviashvili Benjamin-Bona–Mahony (gnKP-BBM) equation, which has several applications in various scientific fields. We invoke Lie’s theory to compute point symmetries of the equation. Using these symmetries the gnKP-BBM equation is reduced to numerous nonlinear ordinary differential equations (NLODEs). Thereafter, solutions of the NLODEs are constructed by using the Jacobi elliptic cosine method, the $(G''/G)$-expansion method, the simplest equation technique and Kudryashov’s method. Furthermore,, we derive conserved quantities of the gnKP-BBM equation by employing the Ibragimov’s method.https://cassyni-user-files-prod.s3.amazonaws.com/C7jKYgVxsujbrm1aXk7kuk https://cassyni.com/slides/outline/88Dx8YaH5u2xo6Zs1k4fQ9 https://cassyni.com/events/88Dx8YaH5u2xo6Zs1k4fQ9/abstract https://cassyni-user-files-prod.s3.amazonaws.com/6xjr7GAh7UCHTVDcp64amU https://cassyni.com/events/88Dx8YaH5u2xo6Zs1k4fQ9?videoPreview=1 Urban fungal diversity shaped by legacy effects of historical meadowsnohttps://cassyni.com/events/88Dx8YaH5u2xo6Zs1k4fQ9?videoPreview=12025-07-09T12:00:00+00:00749.04NoneHistoric land use is an important predictor of current species diversity and distribution across various organism groups. While some evidence links modern landscape configuration to soil biodiversity, the scale at which historical landscape legacies affect soil microbial communities remains unclear. We investigated the response of arbuscular mycorrhizal (AM) fungal diversity to long-term habitat loss and fragmentation due to urbanisation. Soil samples were collected from 764 urban green areas in the city of Tartu, Estonia, where land use has been recorded since the early 20th century. AM fungal diversity was assessed using DNA metabarcoding. Historical proximity to meadows, forests, urban areas, and croplands was derived from historical topographic maps. We found a significant association between AM fungal diversity and historical proximity to meadows: current AM fungal diversity was higher in areas that were within 200 meters of meadows in the early 1900s.  These results demonstrate that past land use continues to shape urban soil microbial communities. Recognising historical landscape legacies is important for understanding present-day biodiversity patterns and should be considered in future urban green space planning and soil conservation strategies https://cassyni-user-files-prod.s3.amazonaws.com/6xjr7GAh7UCHTVDcp64amU https://cassyni.com/events/5dteSaF6BY961tVfi6nQxM/abstract https://cassyni-user-files-prod.s3.amazonaws.com/AEkiJebhhDpq4FQqxgZSn https://cassyni.com/events/5dteSaF6BY961tVfi6nQxM?videoPreview=1 Environmentalism as Adaptive Managementnohttps://cassyni.com/events/5dteSaF6BY961tVfi6nQxM?videoPreview=12006-02-23T09:00:00+00:002660.64 School of Public PolicyAbstract not yet added.https://cassyni-user-files-prod.s3.amazonaws.com/AEkiJebhhDpq4FQqxgZSn https://cassyni.com/slides/outline/3Bjufi72hKVwPzrX1GMfg1 https://cassyni.com/events/3Bjufi72hKVwPzrX1GMfg1/abstract https://cassyni-user-files-prod.s3.amazonaws.com/7VEsSxaj5vAwEKFEKo8uuG https://cassyni.com/events/3Bjufi72hKVwPzrX1GMfg1?videoPreview=1 Electromagnetic absorption beyond the Rozanov bound via time-varying and time-switched lossy layersnohttps://cassyni.com/events/3Bjufi72hKVwPzrX1GMfg1?videoPreview=12025-06-18T23:00:00+00:00668.88ETOPIMAn electromagnetic absorber is a device used to absorb incoming electromagnetic waves for the purpose of stealth, energy harvesting and more. Such devices have been designed in various forms and modes of operation; examples of that are the Salisbury screen [1], which is a resistive layer placed a quarter of a wavelength above a perfect electric conductor (PEC), or the Dallenbach Layer [2], which is a lossy material of quarter-wavelength thickness followed by a PEC. Despite the various designs developed over the years, the absorption performance of any Linear, Time-Invariant (LTI) absorber is bound by the Rozanov bound [3], which establishes a fundamental tradeoff between the reflection coefficient of a metal-backed LTI electromagnetic absorber, the bandwidth over which a desired reflection reduction can be achieved, and the absorber thickness. In this talk we will show that, by lifting the time-invariance assumption in the design of an electromagnetic absorber through the use of a time-varying lossy layer, we can introduce frequency-wavevector transitions allowing for strong destructive interference between each of the generated harmonics of the incoming pulse. This results in enhanced absorption beyond the maximum allowed by the Rozanov bound. As a proof-ofconcept experiment, we designed and tested a transmission-line-equivalent absorber incorporating a timevarying resistance implemented with a single-pole double-throw switch, and we showed that this device can overcome the Rozanov bound for a short pulse having a very broad bandwidth, 8 – 80 MHz [4] [5], with modulation frequencies spanning the range 10 – 50 MHz. Our experimental results show that the improved absorption of the time-varying absorber is dependent on its modulation frequency and, especially, on its modulation phase, highlighting that in a practical scenario a time-varying absorber would require a control system to change its modulation parameters to operate optimally. To further improve upon this work, we will show some preliminary results of an electromagnetic absorber comprising a self-biased time-switched layer that can enhance destructive interference between different components of the incoming pulse. The absorber is implemented as a frequency selective surface and can operate beyond the Rozanov bound while having a thickness that is less than a quarter of the length of the incoming pulse. In conclusion, in this talk we will show how the addition of time-varying and time-switched lossy layers can enable electromagnetic absorbers able to not only operate beyond the Rozanov bound but also to significantly reduce the absorber's physical footprint. These findings open new avenues for the design of compact, high-performance electromagnetic absorbers (and, more broadly, wave absorbers), paving the way for advancements in stealth technology, energy harvesting, and beyond.https://cassyni-user-files-prod.s3.amazonaws.com/7VEsSxaj5vAwEKFEKo8uuG https://cassyni.com/events/NvcRB8QLwvSyWmJQRwxHN5/seminar/qa https://cassyni.com/slides/outline/NvcRB8QLwvSyWmJQRwxHN5 https://cassyni.com/events/NvcRB8QLwvSyWmJQRwxHN5/abstract https://cassyni-user-files-prod.s3.amazonaws.com/MBXsZmfpN9LY7qQV6wRm42 https://cassyni.com/events/NvcRB8QLwvSyWmJQRwxHN5?videoPreview=1 Uncertainty Quantification & Scientific Machine Learningnohttps://cassyni.com/events/NvcRB8QLwvSyWmJQRwxHN5?videoPreview=12025-10-08T13:00:00+00:004246.12ArtIStE - Artificial Intelligence in Structural EngineeringUncertainty Quantification (UQ) and Machine Learning (ML) play an increasingly important role in physics-based computational modeling. Especially with the recent rise of scientific machine learning (SciML) and physics-informed ML, new computational tools are being harnessed to solve bigger and more challenging problems. Moreover, UQ has become an integral part of any physics-based modeling effort because all physics-based models, as carefully developed as they may be, are rife with uncertainties (both epistemic and aleatory) in their parameters, inputs/excitations, and sometimes in the form of the models themselves. When SciML methods are then applied in these applications, additional uncertainties are introduced. In this talk, I will broadly introduce the interrelated roles that UQ and ML play in physics-based modeling. I specifically distinguish between “UQ for ML” and “ML for UQ” and describe the important role that each plays in the modern physics-based computational modeling paradigm. I will present some of our recent advances in UQ/ML including work on Bayesian neural operators, spectral stochastic neural operators, and physics-informed polynomial chaos expansions, with various applications of interest ranging from multi-scale materials modeling, stochastic modeling of structures for natural hazards, and high energy-density physics. https://cassyni-user-files-prod.s3.amazonaws.com/MBXsZmfpN9LY7qQV6wRm42 https://cassyni.com/events/DYHwJ97NcDvkLEbVRvNSmj/seminar/qa https://cassyni.com/slides/outline/DYHwJ97NcDvkLEbVRvNSmj https://cassyni.com/events/DYHwJ97NcDvkLEbVRvNSmj/abstract https://cassyni-user-files-prod.s3.amazonaws.com/SGeys3AHy5qMqsCxWqxcWi https://cassyni.com/events/DYHwJ97NcDvkLEbVRvNSmj?videoPreview=1 Computational modeling of potential targets and lead screening against Monkeypox viruses nohttps://cassyni.com/events/DYHwJ97NcDvkLEbVRvNSmj?videoPreview=12025-10-22T14:30:00+00:002738.84Current Medicinal ChemistryAs Monkeypox (Mpox) has been declared by the World Health Organization (WHO) as a "Public health emergency of international concern" and an important public health alarm by several medical organizations and agencies, it is essential to undertake research and identify potential ideas and foundations to tackle this concern before the emergence of another pandemic post covid. Drug discovery and development are a time-consuming complex protocol, and developing innovative ideas and computational prototypes is an important step to look forward. The recent techniques in data sciences, big data, computational biology, and bioinformatics can work as integrated approaches and contribute innovative and novel predictions and models for drug development against the Mpox virus. The latest tools in Artificial intelligence and machine learning can also produce insightful models for the drug discovery idea that can probably act as a starting foundation to tackle Mpox infection. The special issue mainly aims to welcome cutting-edge ideas and concepts and predictive models emphasize the following areas: • Screening of novel therapeutic targets and Insilco validation of Mpox virus • Molecular modelling and dynamic simulation studies of potential targets of Mpox • Pharmacokinetics and dynamics of the novel lead molecules against Mpox targets • Chemoinformatics and medicinal chemistry approaches to discovering potential small molecules against Mpox • Repurposing of the drugs against Mpox • Applications of data science-driven approaches and network pharmacology against Mpox • Latest applications of AI-based tools and machine learning in tackling Mpox infectionhttps://cassyni-user-files-prod.s3.amazonaws.com/SGeys3AHy5qMqsCxWqxcWi https://cassyni.com/events/A5khyMahY247JYHvnFzVEu/seminar/qa https://cassyni.com/slides/outline/A5khyMahY247JYHvnFzVEu https://cassyni.com/events/A5khyMahY247JYHvnFzVEu/abstract https://cassyni-user-files-prod.s3.amazonaws.com/F4hgxrXrwZHyPMSqDUXZfc https://cassyni.com/events/A5khyMahY247JYHvnFzVEu?videoPreview=1 Applications of Discrete Element Method (DEM) in offshore wind turbine foundation designnohttps://cassyni.com/events/A5khyMahY247JYHvnFzVEu?videoPreview=12025-10-28T12:00:00+00:005255.12Granular MatterMany offshore wind turbines are supported by monopiles and are subjected to millions of cycles of dynamic loadings in their designed service life. There are evidences suggesting that foundation stiffness is changing with cycles of loading and this may lead to changes in the natural frequency of the system with the potential for unplanned system resonances. There are other consequences such as excessive tilt leading to expensive repair or even complete shutdown. Therefore, it is vital to understand the long-term response of wind turbine foundation so that a method to predict the change in frequency and long-term tilt could be established. The first part of the presentation shows the DEM modelling of the interactions between a monopile and the surrounding soil. Micromechanics of soils underlying the soil stiffness change was investigated using DEM. The second part of the presentation considers the local soil behaviour adjacent to monopile under cyclic loading by a series of cyclic simple shear tests. The effects of cycles of shear loading with different shear strain amplitudes and strain profiles were investigated in experiments and DEM simulations.https://cassyni-user-files-prod.s3.amazonaws.com/F4hgxrXrwZHyPMSqDUXZfc https://cassyni.com/slides/outline/PRHeLSZknjvoLEHvE45FYH https://cassyni.com/events/PRHeLSZknjvoLEHvE45FYH/abstract https://cassyni-user-files-prod.s3.amazonaws.com/KZPT1YHrbFsuCxd6nM8Pu8 https://cassyni.com/events/PRHeLSZknjvoLEHvE45FYH?videoPreview=1 Cytochrome P450 enzyme CYP716A catalyzes the biosynthesis of bitter and hemolytic oleanolic acid in the superfood Chenopodium quinoanohttps://cassyni.com/events/PRHeLSZknjvoLEHvE45FYH?videoPreview=12025-08-06T08:30:00+00:0012063.04NoneChenopodium quinoa, a nutritionally rich pseudocereal, is gaining global attention due to its gluten-free, protein-rich seeds. However, the seeds contain bitter-tasting oleanane-type triterpenoid saponins, such as oleanolic acid, which contributes to their bitterness and hemolytic activity. Oleanolic acid is synthesized through the cyclization of 2,3-oxidosqualene by beta-amyrin synthase, followed by oxidation of beta-amyrin, a process catalyzed by cytochrome P450 (CYP) enzymes. While plant genomes contain CYP families involved in sapogenin biosynthesis, the specific enzyme responsible for oleanolic acid synthesis in quinoa was previously unidentified. In this study, we identified the CYP716A enzyme in C. quinoa, which converts beta-amyrin into oleanolic acid. Functional validation through transient overexpression and virus-induced gene silencing (VIGS) in quinoa leaves, along with UPLC-MS analysis, confirmed the role of CYP716A in oleanolic acid biosynthesis. Heterologous expression in tobacco and Arabidopsis further demonstrated CYP716A's involvement in growth and stress responses. These findings identify a novel beta-amyrin 28-oxidase enzyme and provide insights into triterpenoid saponin biosynthesis in quinoa. This research lays the groundwork for developing saponin-free quinoa varieties, which would improve the crop's palatability and health benefits.https://cassyni-user-files-prod.s3.amazonaws.com/KZPT1YHrbFsuCxd6nM8Pu8 https://cassyni.com/events/KxkR1f35iY4AJXzMaPhJ1T/seminar/qa https://cassyni.com/slides/outline/KxkR1f35iY4AJXzMaPhJ1T https://cassyni.com/events/KxkR1f35iY4AJXzMaPhJ1T/abstract https://cassyni-user-files-prod.s3.amazonaws.com/KM6c9ys4NtYsYCG8M1k3pz https://cassyni.com/events/KxkR1f35iY4AJXzMaPhJ1T?videoPreview=1 Introduction to the 25th international Biometals Webinars, Geochemically Relevant Sources of Molybdenum for Anaerobes and Implications for the Evolution of Molybdoenzymes, The impact of iron on bacterial warfarenohttps://cassyni.com/events/KxkR1f35iY4AJXzMaPhJ1T?videoPreview=12026-04-07T13:00:00+00:004929.52BioMetalsMolybdenum (Mo)-containing molybdoenzymes modulate carbon, nitrogen, and sulfur biogeochemical cycles. Among these is Mo-nitrogenase (Nif) that is responsible for >50% of fixed nitrogen introduced to ecosystems. Molybdate (MoO42-) is the only known bioavailable form of Mo, an observation that has been used to suggest Nif (and other molybdoenzymes) could not have originated prior to the widespread O2-dependent oxidation of continental molybdenum sulfides ~2.4 Gya (e.g., MoS2), the primary source of Mo in near surface environments. However, phylogenetic data indicate an origin and early evolution of Nif (and other molybdoenzymes) in anoxic, sulfidic (euxinic) habitats that favor sulfidation of MoO42- to form tetrathiomolybdate (MoS42-) ion and eventually molybdenite (MoS2) mineral. This raises the question as to whether alternative, more geochemically relevant sources of Mo (e.g, MoS42-, MoS2) support the demands of anaerobes. Here, we show that the model nitrogen-fixing anerobic methanogen, Methanococcus maripaludis, can utilize tetrathiomolybdate (MoS42-) and molybdenite mineral (MoS2) as sources of Mo for Nif cofactor (FeMo-co) and molybdopterin (Mo-co) biosynthesis. Cells grown with MoS42- had similar growth kinetics, Mo content, and expression of Mo transporters and FeMo-co and Mo-co biosynthetic genes when compared to those grown with MoO42-. Results imply that molybdoenzymes could have originated during the Archean, when alternative forms of Mo such as tetrathiomolybdate or molybdenite were more prevalent. Bacteria have evolved a diverse array of mechanisms to inhibit and kill competitors. However, why some bacteria carry specific weapons over others remains poorly understood. Here we explore this question using the genomics of the bacteriocins of E. coli as a model system, which have large well-annotated bioinformatic resources. While bacteriocins occur widely, we find that carriage of weaponry that hijacks receptors involved in iron siderophore uptake is particularly associated with pathogenic extra-intestinal (ExPEC) strains. These pathogens commonly carry large plasmids encoding bacteriocins alongside siderophores, other virulence factors and antimicrobial resistance mechanisms. We predict that these plasmids increase the fitness of E. coli strains under low iron conditions such as gut inflammation, allowing harmful strains to persist in the gut microbiome and cause disease.https://cassyni-user-files-prod.s3.amazonaws.com/KM6c9ys4NtYsYCG8M1k3pz https://cassyni.com/events/WLN6z1d6w9gaq3HVbVeBgy/seminar/qa https://cassyni.com/slides/outline/WLN6z1d6w9gaq3HVbVeBgy https://cassyni.com/events/WLN6z1d6w9gaq3HVbVeBgy/abstract https://cassyni-user-files-prod.s3.amazonaws.com/7wnK5ry59i4LawAPRvx5mp https://cassyni.com/events/WLN6z1d6w9gaq3HVbVeBgy?videoPreview=1 Deepfake Detection in the Era of Generative AInohttps://cassyni.com/events/WLN6z1d6w9gaq3HVbVeBgy?videoPreview=12025-11-04T13:00:00+00:003334.04Journal on Image and Video ProcessingWith the rapid progress of recent years, techniques that generate and manipulate multimedia content can now provide a very advanced level of realism. Powered by large language models, text-driven synthesis tools allow the user to modify or create from scratch images and videos by means of simple text instructions. On the one hand, this opens the door to a series of exciting applications in different fields such as creative arts, advertising, film production, video games. On the other hand, it poses enormous security threats. Therefore, there is an urgent need for automated tools capable of detecting false multimedia content and avoiding the spread of dangerous false information. This talk aims to present an analysis of the methods for deepfake detection. Special emphasis will be placed on the phenomenon of AI-generated content and on modern data-driven forensic methods to fight them. The analysis will help highlight the limits of current forensic tools, the most relevant issues, the upcoming challenges, and suggest future directions for research.https://cassyni-user-files-prod.s3.amazonaws.com/7wnK5ry59i4LawAPRvx5mp https://cassyni.com/slides/outline/DB7bc2pLrDGrXNUFga18H https://cassyni.com/events/DB7bc2pLrDGrXNUFga18H/abstract https://cassyni-user-files-prod.s3.amazonaws.com/AnnmcQp1MB1HwAuyAaXkdC https://cassyni.com/events/DB7bc2pLrDGrXNUFga18H?videoPreview=1 The Art Of Drug Designnohttps://cassyni.com/events/DB7bc2pLrDGrXNUFga18H?videoPreview=12025-07-16T06:00:00+00:004042.24The Pharmacological Research family of journalsStep into the fascinating world of drug discovery as Asst. Prof. Duangrudee Tanramluk takes you on a journey through the art of designing medicines. From visualizing the intricate details of atoms and amino acids to discovering how molecular docking and fragment-based approaches pave the way for innovative treatments, this talk brings drug design to life. Explore how antidepressants are crafted to target serotonin transporters, understand drug-target interactions through creative analogies of "kitty wearing masks," and see how tools like MANORAA are revolutionizing the field. Whether you're curious about how drugs are designed or eager to shape the future of pharmacology, this lecture will inspire anyone passionate about the science behind drug discovery and the future of pharmacology.https://cassyni-user-files-prod.s3.amazonaws.com/AnnmcQp1MB1HwAuyAaXkdC https://cassyni.com/slides/outline/EXXuAFNegRBY4AyHq891em https://cassyni.com/events/EXXuAFNegRBY4AyHq891em/abstract https://cassyni-user-files-prod.s3.amazonaws.com/DFFSnii5Jzmz1UnBq2crvr https://cassyni.com/events/EXXuAFNegRBY4AyHq891em?videoPreview=1 A Synthesis for The Science of Sciencenohttps://cassyni.com/events/EXXuAFNegRBY4AyHq891em?videoPreview=12022-05-06T08:00:00+00:002209.48 School of Public PolicyThis synthesis examines the multifaceted domain of the science of science through an integrative survey of its meta-sciences, including philosophy, history, sociology, and economics of science. The analysis foregrounds enduring questions about the nature, demarcation, and justification of scientific knowledge, tracing philosophical inquiries from classical antiquity through modern debates on reproducibility, falsification, and the role of human and non-human agents in evidence generation. Historical perspectives reveal evolving narratives of scientific progress, shifting from linear accounts of great individuals to more nuanced considerations of material culture, embodiment, and social context. Sociological frameworks emphasize the influence of prevailing thought styles, social norms, and stratifications on scientific practice, highlighting mechanisms such as the Matthew effect and the social construction of scientific realities. Economic approaches address science as a public good, exploring funding, resource allocation, and the interplay between institutional structures and scientific productivity. The synthesis underscores the emergence and institutionalization of science of science as a distinct field, catalyzed by developments like the Science Citation Index and scientometric methodologies, while noting ongoing debates about responsible metrics and epistemic justice. Central to this agenda is the interrogation of who defines knowledge, who is marginalized or privileged in scientific histories and resource distributions, and how these dynamics shape the production and application of knowledge. The study advocates for integrative, interdisciplinary approaches to address epistemic injustices and enhance the robustness and social responsibility of scientific enterprise.https://cassyni-user-files-prod.s3.amazonaws.com/DFFSnii5Jzmz1UnBq2crvr https://cassyni.com/events/9b3rhQuQHqeWf5FwpeS1vd/abstract https://cassyni-user-files-prod.s3.amazonaws.com/MXcBtPsSfnSE2g4wQm7VjU https://cassyni.com/events/8bqWwwA1d1KB2J1DDQFWzZ/seminar/qa https://cassyni.com/slides/outline/8bqWwwA1d1KB2J1DDQFWzZ https://cassyni.com/events/8bqWwwA1d1KB2J1DDQFWzZ/abstract https://cassyni-user-files-prod.s3.amazonaws.com/8KGWsNhiUoUQqg8ip5qUgW https://cassyni.com/events/8bqWwwA1d1KB2J1DDQFWzZ?videoPreview=1 Towards Efficient Volumetric Video: Compression and Standardization of Gaussian Splatsnohttps://cassyni.com/events/8bqWwwA1d1KB2J1DDQFWzZ?videoPreview=12025-12-18T13:00:00+00:003718.04Journal on Image and Video ProcessingRecent advances in novel view synthesis have enabled high-quality volumetric video from real-world imagery, bringing photorealistic immersive media closer to practical deployment. 3D Gaussian Splatting achieves real-time rendering, but at the cost of significantly higher memory usage compared to NeRF, exposing a key trade-off between speed and storage. Efficient compression is therefore essential to reduce memory footprints while preserving real-time performance. This talk will introduce GSCodec Studio, a toolbox integrating modular compression techniques for Gaussian Splats, followed by an exploration of 4D scene representations and corresponding compression methods for volumetric video. Finally, I will discuss recent exploration efforts within MPEG toward standardizing Gaussian Splatting codecs to enable broad industry adoption.https://cassyni-user-files-prod.s3.amazonaws.com/8KGWsNhiUoUQqg8ip5qUgW https://cassyni.com/events/UrSuxbCR28wyHLLLSM9KQZ/seminar/qa https://cassyni.com/slides/outline/UrSuxbCR28wyHLLLSM9KQZ https://cassyni.com/events/UrSuxbCR28wyHLLLSM9KQZ/abstract https://cassyni-user-files-prod.s3.amazonaws.com/5mSCxzW2nYQGmHDecqiCoY https://cassyni.com/events/UrSuxbCR28wyHLLLSM9KQZ?videoPreview=1 High-performance polyester reverse osmosis membranes ---- design, fabrication, and future perspectivenohttps://cassyni.com/events/UrSuxbCR28wyHLLLSM9KQZ?videoPreview=12026-03-18T10:00:00+00:002969.48ElsevierThin-film composite (TFC) reverse osmosis (RO) membranes have remained the gold-standard technology for desalination and water purification over the past half-century. Polyamide films offer excellent water permeability and salt rejection but also suffer from poor chlorine resistance, high fouling propensity, and low boron rejection. In this talk, we would like to discuss the design strategy for new monomeric precursors based on aromatic phenols that are suitable for fabricating polyester RO membranes using the same interfacial polymerization protocol as for polyamide membranes. Moreover, we will also show the excellent performance of the polyester membranes, including high water permeability, high rejection of NaCl and boron, and complete resistance to chlorine. The unique surface properties of the polyester membranes are then analyzed, which indicate an ultrasmooth, low-energy surface and thus prevent membrane fouling and mineral scaling, compared with polyamide membranes. Finally, we will also discuss the challenges of polyester membranes in practical applications and large-scale manufacturing. https://cassyni-user-files-prod.s3.amazonaws.com/5mSCxzW2nYQGmHDecqiCoY https://cassyni.com/events/FWYt7KWqXj2RG9qH5RDv9T/seminar/qa https://cassyni.com/slides/outline/FWYt7KWqXj2RG9qH5RDv9T https://cassyni.com/events/FWYt7KWqXj2RG9qH5RDv9T/abstract https://cassyni-user-files-prod.s3.amazonaws.com/PjVWTH5CxRZURTqz1rUn4N https://cassyni.com/events/FWYt7KWqXj2RG9qH5RDv9T?videoPreview=1 The Anatomy of Autonomynohttps://cassyni.com/events/FWYt7KWqXj2RG9qH5RDv9T?videoPreview=12026-03-11T15:00:00+00:004059.84AIAAJoin us for a discussion of the book *The Anatomy of Autonomy*.https://cassyni-user-files-prod.s3.amazonaws.com/PjVWTH5CxRZURTqz1rUn4N https://cassyni.com/slides/outline/GzoYWJ8AH4t5J8Up56EByF https://cassyni.com/events/GzoYWJ8AH4t5J8Up56EByF/abstract https://cassyni-user-files-prod.s3.amazonaws.com/XY7R4LwNhMGD5ZzbVLUnBY https://cassyni.com/events/GzoYWJ8AH4t5J8Up56EByF?videoPreview=1 What Can Social Science Contribute to Cybersecurity Attribution Research?nohttps://cassyni.com/events/GzoYWJ8AH4t5J8Up56EByF?videoPreview=12017-09-15T08:00:00+00:003279.48 School of Public PolicyCybersecurity attribution, the process of identifying responsible actors behind cyberattacks, is increasingly recognized as a complex issue extending beyond technical analysis to encompass behavioral, legal, and institutional dimensions. This analysis foregrounds the necessity for attribution to be accepted as objective and authoritative by a broad community capable of enforcing accountability, emphasizing that technical evidence alone is insufficient without widespread legitimacy. Drawing on principles from the philosophy of science, the study highlights the importance of transparent methodologies, reproducible results, and open adversarial debate to achieve intersubjectivity—shared acceptance of findings among diverse stakeholders. The challenge intensifies in attributing attacks to nation-state actors, whose significant resources and geopolitical rivalries complicate consensus on attribution. Two international relations perspectives are considered: realism, which views attribution as contingent on state interests and power without overarching enforcement, and institutionalism, which posits potential for cooperative international mechanisms. The Microsoft-proposed Digital Geneva Convention exemplifies an institutionalist approach, advocating for a neutral, non-governmental international organization to attribute major state-sponsored cyberattacks, focusing on critical infrastructure and operating without enforcement powers. Key research questions include funding models, incentive structures, standardization of attribution methods, and the feasibility of global cooperation amid distrust and political tensions. The analysis underscores that even with credible attribution, the effectiveness in altering state behavior depends on established norms of deterrence and retaliation, which remain underdeveloped. This interdisciplinary inquiry suggests that integrating social science insights into cybersecurity attribution could enhance the legitimacy, governance, and accountability mechanisms essential for managing cyber conflict at the international level.https://cassyni-user-files-prod.s3.amazonaws.com/XY7R4LwNhMGD5ZzbVLUnBY https://cassyni.com/slides/outline/KU3ZjiMnUMeZf4xNcn8phB https://cassyni.com/events/KU3ZjiMnUMeZf4xNcn8phB/abstract https://cassyni-user-files-prod.s3.amazonaws.com/WBL1BTugVLjzA5CG1D84Tx https://cassyni.com/events/KU3ZjiMnUMeZf4xNcn8phB?videoPreview=1 Rebuilding the Civic Square panel discussionnohttps://cassyni.com/events/KU3ZjiMnUMeZf4xNcn8phB?videoPreview=12021-02-08T09:00:00+00:003970.64 School of Public PolicyThis panel discussion addresses the contemporary challenges facing American democracy, focusing on the concept of rebuilding the civic square through civil, informed, and respectful discourse. Drawing on historical and current political contexts, the dialogue explores the nature of political division, emphasizing that while the United States is deeply fragmented across multiple ideological and interest-based lines, such diversity has historically been a safeguard for liberty rather than a sign of collapse. The discussion highlights the distinction between unity and union, advocating for a shared purpose and identity as Americans despite differing opinions. Key themes include the necessity of good faith engagement, openness to opposing viewpoints, and the individual responsibility to participate actively in civic life beyond episodic voting. Panelists underscore the role of leaders committed to civil discourse and the importance of creating institutional spaces—such as universities—that facilitate meaningful exchanges across divides. The conversation also reflects on the impact of media narratives and tribalism on political polarization, suggesting that personal interactions and sustained dialogue can foster understanding. The panel concludes with cautious optimism, recognizing current deficits in civil discourse but affirming the potential for recovery through collective effort, historical perspective, and renewed commitment to democratic principles. This analysis offers insights into the dynamics of political polarization and the prospects for restoring constructive civic engagement in the United States.https://cassyni-user-files-prod.s3.amazonaws.com/WBL1BTugVLjzA5CG1D84Tx https://cassyni.com/slides/outline/XpFftoXuSoVRYkCBb8hYqK https://cassyni.com/events/XpFftoXuSoVRYkCBb8hYqK/abstract https://cassyni-user-files-prod.s3.amazonaws.com/YUJTtZzRLu5VfDqedFqvvA https://cassyni.com/events/XpFftoXuSoVRYkCBb8hYqK?videoPreview=1 Water Quality Paradoxes in Rich and Poor Nations: Insights from Sri Lanka and Remote Australianohttps://cassyni.com/events/XpFftoXuSoVRYkCBb8hYqK?videoPreview=12025-08-14T08:00:00+00:001068.96Cambridge PrismsThis interview explores the pressing challenges and responses related to drinking water quality in two regions that contrast in terms of national wealth: Sri Lanka, a developing country, and remote Australia, part of a highly developed nation. Despite their contrasting economic contexts, both regions face significant challenges in ensuring access to safe drinking water. In Sri Lanka, progress has been made through centralized government initiatives focused on infrastructure expansion, policy reform, and alignment with Sustainable Development Goal 6. However, challenges remain, including climate change impacts, rural infrastructure gaps, and source water contamination. In remote Australia, geographic isolation, aging infrastructure, and environmental extremes hinder consistent water quality, but solutions are emerging, albeit at a slow pace - through community engagement, decentralized treatment systems, and technological innovations. The comparison highlights how each region, though differing in resources and governance models, is pursuing context-specific strategies to secure clean water for its populations. The discussion concludes that money alone does not guarantee clean water. It reveals how geography, environmental conditions, governance, and inequality can override national wealth in determining water access and safety. The consequences for public health can be just as severe in both settings. Political will - combined with sustained policy and investment, the innovation and selection of appropriate technologies, and strong collaboration among all stakeholders, including the application of intergovernmental lessons learned, will be key to ensuring future success in securing safe drinking water for all.https://cassyni-user-files-prod.s3.amazonaws.com/YUJTtZzRLu5VfDqedFqvvA https://cassyni.com/events/SP82PHR8cmQM9swwzDhkqs/abstract https://cassyni-user-files-prod.s3.amazonaws.com/NEHgYDfZAHiEhiR7vdqCSA https://cassyni.com/events/SP82PHR8cmQM9swwzDhkqs?videoPreview=1 Solar Geoengineering’s Place in Broader Climate Strategynohttps://cassyni.com/events/SP82PHR8cmQM9swwzDhkqs?videoPreview=12023-09-28T08:00:00+00:004680.56 School of Public PolicyIf solar geoengineering is deployed, it will likely occur alongside other key climate strategies, such as emission mitigation, CO2 removal, and adaptation. The aim of this session is to describe the role of SG under different development of mitigation and adaptation policies, assuming countries cooperate to fight climate changehttps://cassyni-user-files-prod.s3.amazonaws.com/NEHgYDfZAHiEhiR7vdqCSA https://cassyni.com/events/TN91LMZKU5FEMrowEWnfLZ/seminar/qa https://cassyni.com/slides/outline/TN91LMZKU5FEMrowEWnfLZ https://cassyni.com/events/TN91LMZKU5FEMrowEWnfLZ/abstract https://cassyni-user-files-prod.s3.amazonaws.com/K1f4Ukor8Jd4V4iRMtphGJ https://cassyni.com/events/TN91LMZKU5FEMrowEWnfLZ?videoPreview=1 Thieme Cheminar: Thieme Chemistry Journals Awardees 2026nohttps://cassyni.com/events/TN91LMZKU5FEMrowEWnfLZ?videoPreview=12026-03-30T14:00:00+00:008322.56Thieme GroupThis seminar presented recent advancements across diverse fields of chemical synthesis and separation technologies, as highlighted by five award-winning research contributions. One area focused on developing energy-efficient membrane systems for organic solvent recovery in the pharmaceutical industry, employing pervaporation for separating azeotropic mixtures like water-isopropanol with demonstrated energy savings and reduced CO2 footprint. Nanofiltration was also applied to curcumin extraction, identifying acetone as a superior solvent and proposing a circular solvent recovery scheme. Another contribution involved the design and synthesis of bench-stable selenium(III) sources, overcoming instability issues by promoting head-to-head oligomerization. These cationic selenuranes, prepared on a multi-gram scale and characterized by X-ray crystallography to reveal unique 2.7 Å Se–Se bond distances, exhibited diverse reactivity for preparing selenonium salts and Umemoto reagents. Further research explored novel routes to 1,2-diazepines and related complex heterocyclic structures from pyridines via photochemical rearrangements. A multi-step protocol, improved with in-situ generated isocyanates, afforded diazepines in high yields, whose reactivity was then exploited for the diastereoselective synthesis of fused β-lactams and oxazinones. The photomodulation of lanthanoid luminescence was also addressed, leveraging diazocine photoswitches to achieve up to 93% luminescence intensity switching and 1.3 ms lifetime changes in Eu(III), Tb(III), and Yb(III) dipicolinates through a combination of competitive absorption, reabsorption, and excited state depopulation mechanisms. Finally, novel catalytic strategies were presented for carbohydrate functionalization, using σ-hole-based halogen- and chalcogen-bonding catalysts to achieve high anomeric and regioselectivity in glycosylations and ring expansions, alongside asymmetric catalysis for site-selective polyfunctionalization of complex saccharides.https://cassyni-user-files-prod.s3.amazonaws.com/K1f4Ukor8Jd4V4iRMtphGJ https://cassyni.com/slides/outline/SsmdRy4f4DxQ9eUqaezZ7B https://cassyni.com/events/SsmdRy4f4DxQ9eUqaezZ7B/abstract https://cassyni-user-files-prod.s3.amazonaws.com/3zxyjEcsE5QS7xTXguNKMg https://cassyni.com/events/SsmdRy4f4DxQ9eUqaezZ7B?videoPreview=1 Navigating the (Mis)Perceptions of Autonomous Vehiclesnohttps://cassyni.com/events/SsmdRy4f4DxQ9eUqaezZ7B?videoPreview=12019-11-14T09:00:00+00:005334.84 School of Public PolicyThis seminar explores the multifaceted realities and misconceptions surrounding autonomous vehicles (AVs), emphasizing their societal, ethical, and technological dimensions. The discussion situates AVs within a broad spectrum of autonomous transportation modes, including aerial drones and rail systems, highlighting the complexity of operational environments as a critical factor influencing autonomy challenges. Key issues addressed include the overhype of fully autonomous (Level 5) vehicles, which remain distant from widespread deployment, and the incremental integration of driver assistance technologies currently available. The panel underscores the potential benefits of AVs, such as enhanced mobility for disabled and non-driving populations and significant safety improvements by reducing human error, which accounts for approximately 90% of fatal accidents. However, concerns are raised regarding user expectations, human-machine interaction, privacy, data monetization, and the ethical implications embedded in design decisions, including the limitations of focusing narrowly on dilemmas like the trolley problem. The discussion also highlights systemic impacts, such as urban planning changes, secondary effects on crime and public health, and the need for interdisciplinary collaboration among engineers, ethicists, policymakers, and affected communities. Challenges in regulatory frameworks and standards development are noted, with calls for open, flexible, and international standards that accommodate rapid technological evolution. The seminar concludes with consensus on the necessity of cautious, inclusive, and transparent approaches to AV development and deployment, balancing innovation with ethical responsibility and societal well-being.https://cassyni-user-files-prod.s3.amazonaws.com/3zxyjEcsE5QS7xTXguNKMg https://cassyni.com/slides/outline/D3ci8pwxmQSvWU28fye9NM https://cassyni.com/events/D3ci8pwxmQSvWU28fye9NM/abstract https://cassyni-user-files-prod.s3.amazonaws.com/KptHMC4ZT8e8wP3zryKpSi https://cassyni.com/events/D3ci8pwxmQSvWU28fye9NM?videoPreview=1 Breaking the Alfvén wave: harder than it looksnohttps://cassyni.com/events/D3ci8pwxmQSvWU28fye9NM?videoPreview=12024-01-11T06:00:00+00:002437.72Journal of Plasma PhysicsThe Alfvén wave is ubiquitous in the solar wind. In particular, NASA’s Parker Solar Probe, currently exploring the outer edges of the corona, has revealed frequent patches of extremely large-amplitude waves (∆B/B ~1), often even locally reversing the direction of the background magnetic field - these structures have therefore been dubbed “switchbacks”. Often, switchbacks also exhibit extremely sharp boundaries, with large magnetic field rotations over only a few ion inertial lengths. I will attempt to answer several questions suggested by these new observations: How do these waves attain such large amplitudes while maintaining their Alfvénic character? How do they develop such sharp discontinuities? And how are these discontinuities maintained? I will show that the Alfvén wave is surprisingly resilient, and is able to survive unscathed at very large amplitude and even at relatively small scales. These results have interesting implications for the heating of the corona and solar wind by imbalanced Alfvénic turbulence.https://cassyni-user-files-prod.s3.amazonaws.com/KptHMC4ZT8e8wP3zryKpSi https://cassyni.com/slides/outline/FWrjNFBaxhDQsQVhDfYn6H https://cassyni.com/events/FWrjNFBaxhDQsQVhDfYn6H/abstract https://cassyni-user-files-prod.s3.amazonaws.com/QzMD1Y21VkWpjiGUGvYYBx https://cassyni.com/events/FWrjNFBaxhDQsQVhDfYn6H?videoPreview=1 Tearing and secondary instabilities in collisionless plasmas based on gyrofluid modelingnohttps://cassyni.com/events/FWrjNFBaxhDQsQVhDfYn6H?videoPreview=12023-07-20T06:00:00+00:003042.48Journal of Plasma PhysicsThis talk presents the application of a Hamiltonian gyrofluid approach allowing to account for finite Larmor radius corrections, parallel magnetic field fluctuations, and electron inertia, in the study of magnetic reconnection and related secondary instabilities. Non-collisional current sheets that form during the nonlinear development of spontaneous magnetic reconnection are characterized by a small thickness comparable to the electron skin depth and can become unstable, leading to the formation of plasmoids and facilitating high reconnection rates. In the context of cold ions with negligible parallel velocity, we investigate the marginal stability conditions for plasmoid formation in collisionless plasma, considering the impact of finite but moderate βe, a regime that has seen little investigation before. These results are tested against gyrokinetic simulations, showing a very good agreement. The gyrofluid approach also enables the study of the transition from the cold to the hot-ion regime. By considering a regime with small βe and hot ions, we present an analysis of the turbulent regime arising from Kelvin-Helmholtz-like secondary instabilities outside magnetic islands, resulting in the formation of magnetic vortices. Turbulence develops at scales smaller than the electron skin depth, with a magnetic energy spectrum exponent close to -11/3 as predicted by strong-turbulence phenomenology.https://cassyni-user-files-prod.s3.amazonaws.com/QzMD1Y21VkWpjiGUGvYYBx https://cassyni.com/slides/outline/C4KW3TeutVLmqiC8a1ApZT https://cassyni.com/events/C4KW3TeutVLmqiC8a1ApZT/abstract https://cassyni-user-files-prod.s3.amazonaws.com/4Gz86P5Tkw7NrgMpKmzpZU https://cassyni.com/events/C4KW3TeutVLmqiC8a1ApZT?videoPreview=1 Building Organisations That Can Thrive in a Changing Worldnohttps://cassyni.com/events/C4KW3TeutVLmqiC8a1ApZT?videoPreview=12025-07-31T08:00:00+00:003422.8Business SchoolThe increasing complexity and rapid disruption in today’s business environment demand new organizational and leadership approaches to thrive. Traditional management models, rooted in early 20th-century industrial paradigms, are insufficient for addressing the dynamic challenges posed by technological advances, geopolitical tensions, and global crises such as pandemics and climate change. This analysis employs the Cynefin framework to categorize organizational problems into four domains—clear, complicated, complex, and chaotic—each requiring distinct management and leadership styles. Clear and complicated domains benefit from traditional, plan-driven management and expert analysis, whereas complex domains necessitate empirical, iterative approaches emphasizing experimentation, learning, and adaptation. Chaotic situations demand immediate, decisive action to restore order before transitioning to other domains. Leadership in complex environments must foster psychological safety and a growth mindset, enabling teams to innovate and navigate uncertainty collaboratively. Motivational factors critical to enhancing adaptive performance include play, purpose, and potential, while emotional pressure, economic pressure, and inertia hinder adaptability. Empirical evidence indicates that meaningful work significantly influences employee engagement, with many willing to sacrifice substantial future earnings for purpose-driven roles. The findings underscore the imperative for organizations to redesign structures, cultivate adaptive leadership, and embed iterative, evidence-based work cycles to respond effectively to ongoing complexity and disruption. Future directions include expanding leadership development focused on adaptability and fostering organizational cultures that prioritize psychological safety and intrinsic motivation.https://cassyni-user-files-prod.s3.amazonaws.com/4Gz86P5Tkw7NrgMpKmzpZU https://cassyni.com/events/NRxp8SkpWTtvWzmWqWfV6m/seminar/qa https://cassyni.com/slides/outline/NRxp8SkpWTtvWzmWqWfV6m https://cassyni.com/events/NRxp8SkpWTtvWzmWqWfV6m/abstract https://cassyni-user-files-prod.s3.amazonaws.com/44VF6svQbKFHoHMah9JSjp https://cassyni.com/events/NRxp8SkpWTtvWzmWqWfV6m?videoPreview=1 Synthesis and Properties of SmN Thin Films grown on MgO(001)nohttps://cassyni.com/events/NRxp8SkpWTtvWzmWqWfV6m?videoPreview=12025-09-17T22:00:00+00:003590.76School of Chemical and Physical SciencesWe demonstrate the growth of high-quality SmN thin films on MgO(001) using molecular beam epitaxy. Furthermore, the SmN electronic properties can be effectively tuned during growth by controlling the synthesis parameters, driving the film from an insulating ferromagnetic state to a ferromagnetic metallic state. We do not observe signatures of superconductivity in any of the samples synthesized, even down to 0.35 K. We discuss possible scenarios for the absence of superconductivity in these films and examine implications for the underlying pairing mechanism in this material. Our results provide a pathway for high-quality synthesis of SmN thin films and its potential monolithic integration in spintronic devices based on rare-earth nitride systems. https://cassyni-user-files-prod.s3.amazonaws.com/44VF6svQbKFHoHMah9JSjp https://cassyni.com/slides/outline/HVUmfcHa7tMu7u4Aq2xVNd https://cassyni.com/events/HVUmfcHa7tMu7u4Aq2xVNd/abstract https://cassyni-user-files-prod.s3.amazonaws.com/BaNDXmLc2sPs57z1Db4AHc https://cassyni.com/events/HVUmfcHa7tMu7u4Aq2xVNd?videoPreview=1 Safeguarding the polar regions from dangerous geoengineering: a critical assessment of proposed and future prospectsnohttps://cassyni.com/events/HVUmfcHa7tMu7u4Aq2xVNd?videoPreview=12025-09-24T09:00:00+00:005627.76Frontiers in Science### Geoengineering: solutions or distractions to the climate crisis? This session explores the technical feasibility, long-term costs, environmental risks, and governance limitations of five approaches. Examine the scientific and policy challenges of deploying polar geoengineering tools as a climate mitigation strategy. Hear from the authors of a [Frontiers in Science lead article](https://www.frontiersin.org/journals/science/articles/10.3389/fsci.2025.1527393/full)—including a representative of the Intergovernmental Panel on Climate Change (IPCC)—as they analyze five polar geoengineering proposals: aerosol injection, sea walls, ice albedo modification, basal water removal, and ocean fertilization. The researchers will outline their conclusions that these proposed interventions would harm the fragile polar ecosystems they intend to protect, and how the proposals fail to meet core scientific and policy criteria. Our expert panel will also discuss how these initiatives may detract from achieving Net Zero, by diverting time, funding, and attention from efforts toward achieving deep decarbonization. [Click here to register.](https://events.frontiersin.org/polar-geoengineering/cassyni)https://cassyni-user-files-prod.s3.amazonaws.com/BaNDXmLc2sPs57z1Db4AHc https://cassyni.com/events/QuCqMrzShkfjcUadnupDnd/abstract https://cassyni-user-files-prod.s3.amazonaws.com/WbfYLA2CoxkzNfWjtanyDG https://cassyni.com/slides/outline/TNSrbHE4u3SDyR4CLbirWZ https://cassyni.com/events/TNSrbHE4u3SDyR4CLbirWZ/abstract https://cassyni-user-files-prod.s3.amazonaws.com/69a8YKVj5oMnC1JuMfB51Y https://cassyni.com/events/TNSrbHE4u3SDyR4CLbirWZ?videoPreview=1 The baby brain: Learning in leaps and boundsnohttps://cassyni.com/events/TNSrbHE4u3SDyR4CLbirWZ?videoPreview=12023-03-24T06:00:00+00:004002.96Part of the nonprofit Annual Reviews organizationLearn how the baby brain changes from pregnancy to toddlerhood, and what parents, teachers and policymakers can do to ensure kids are set up for success. This event is part of an ongoing series of live events and science journalism from Knowable Magazine and Annual Reviews, a nonprofit publisher dedicated to synthesizing and integrating knowledge for the progress of science and the benefit of society. "The baby brain: Learning in leaps in bounds" is supported by a grant from the Dana Foundation. a private philanthropic organization dedicated to advancing neuroscience and society. https://cassyni-user-files-prod.s3.amazonaws.com/69a8YKVj5oMnC1JuMfB51Y https://cassyni.com/slides/outline/87AHnczbnBqMCq1hRJ8YpM https://cassyni.com/events/87AHnczbnBqMCq1hRJ8YpM/abstract https://cassyni-user-files-prod.s3.amazonaws.com/TQtbprEux6odQF7bx4LZC https://cassyni.com/events/87AHnczbnBqMCq1hRJ8YpM?videoPreview=1 Stress and Resilience in the Pandemic and Beyondnohttps://cassyni.com/events/87AHnczbnBqMCq1hRJ8YpM?videoPreview=12020-12-09T06:00:00+00:003840.08Part of the nonprofit Annual Reviews organizationWhat are the keys to building psychological resilience in the face of difficulties? What does research reveal about how coping strategies lessen or worsen the damage from stress and trauma? How do those recommendations need to shift, given the realities of Covid? And how might people cope with the double stress of the pandemic and the holidays? One key, researchers say, may be focusing on flexibility. Join a discussion of the science of resilience and coping with clinical psychologist George Bonanno, who has studied how veterans and others respond to trauma and loss, and social psychologist Judith T. Moskowitz, whose work with patients diagnosed with HIV and cancer has helped uncover the power of effective coping methods. The speakers will share their insights on what steps can be taken now to protect against the long-reaching assaults of stress on our physical and mental health. https://cassyni-user-files-prod.s3.amazonaws.com/TQtbprEux6odQF7bx4LZC https://cassyni.com/slides/outline/2g2eH6spx9kGoxmTpP8kpu https://cassyni.com/events/2g2eH6spx9kGoxmTpP8kpu/abstract https://cassyni-user-files-prod.s3.amazonaws.com/T3N3TgLxmS4Zs6eaCJ8rkv https://cassyni.com/events/2g2eH6spx9kGoxmTpP8kpu?videoPreview=1 Neural Network Implementation of Finite Element Models for Fluid-Structure Interactionnohttps://cassyni.com/events/2g2eH6spx9kGoxmTpP8kpu?videoPreview=12025-06-12T06:00:00+00:001539.84Leeds Institute for Fluid DynamicsFluid-structure interaction (FSI) is an important phenomenon in many engineering problems. Numerical solvers for FSI have conventionally focused on central processing units (CPUs). However, hardware is advancing rapidly, partly driven by machine learning applications. Representing numerical solvers with neural networks and implementing them with machine learning packages can bring advantages such as hardware agnosticism, automatic differentiation, and easy integration with data-driven models. In this talk, I will report an implementation of unstructured finite element solvers using graph neural networks and show its architecture agnosticism with tests on graphics processing units (GPUs). Specifically, high-order discontinuous Galerkin methods with an interior penalty scheme are adopted. The approach is first demonstrated on diffusion problems to illustrate the graph representation of an unstructured mesh, matrix-free residual evaluation inside neural networks, and a multigrid method consisting of p-multigrid levels and algebraic multigrid levels, which is shown to be scalable and robust. The approach is then extended to hyper-elasticity, incompressible flow, and finally, FSI problems. Overall, the approach has shown promising speed in diffusion and hyper-elasticity compared to some highly optimised implementations in the literature while maintaining high accuracy, i.e. (p+1)-order convergence for p-th order elements, in the three types of problems.https://cassyni-user-files-prod.s3.amazonaws.com/T3N3TgLxmS4Zs6eaCJ8rkv https://cassyni.com/slides/outline/3AgFKnXMPcJKojJMQpRZ6D https://cassyni.com/events/3AgFKnXMPcJKojJMQpRZ6D/abstract https://cassyni-user-files-prod.s3.amazonaws.com/PqmKB5yYmtqbWJvm4CDNtn https://cassyni.com/events/3AgFKnXMPcJKojJMQpRZ6D?videoPreview=1 LIFD get to know usnohttps://cassyni.com/events/3AgFKnXMPcJKojJMQpRZ6D?videoPreview=12023-10-24T06:00:00+00:001775.8Leeds Institute for Fluid DynamicsThe Leeds Institute for Fluid Dynamics (LIFD) is a cross-disciplinary research institute encompassing over 300 members across 12 schools and four faculties at the University of Leeds. Established five years ago, LIFD covers a comprehensive range of fluid dynamics research, from nanoscale to astrophysical phenomena, integrating fundamental, computational, data-driven, and experimental approaches. The institute actively collaborates internationally with partners in over 100 countries and contributes to national fluid dynamics initiatives, including fellowship schemes and strategic research reports. Central to LIFD’s mission is the Centre for Doctoral Training (CDT) in Fluid Dynamics, which offers an integrated Master’s and PhD program with broad training in technical and transferable skills. The CDT engages with industry and academic partners through sponsored projects, mentorship, placements, and advisory roles, fostering interdisciplinary research spanning engineering, environment, biology, and physics. LIFD facilitates diverse collaboration pathways, including visiting fellowships at multiple career stages, industrial engagement fellowships, knowledge transfer partnerships, and Innovate UK-funded projects. Support extends to consultancy, co-funded PhDs, and long-term strategic partnerships. The institute also provides outreach activities, seminars, and training events to disseminate fluid dynamics knowledge. Upcoming initiatives include an industrial fellowship scheme and celebratory events marking LIFD’s fifth anniversary. LIFD offers access to cutting-edge research expertise, facilities, and highly qualified graduates, aiming to advance fluid dynamics understanding and its application across academia, industry, and societal challenges.https://cassyni-user-files-prod.s3.amazonaws.com/PqmKB5yYmtqbWJvm4CDNtn https://cassyni.com/events/DXz63DSdBFjkigMEKqSFbj/seminar/qa https://cassyni.com/slides/outline/DXz63DSdBFjkigMEKqSFbj https://cassyni.com/events/DXz63DSdBFjkigMEKqSFbj/abstract https://cassyni-user-files-prod.s3.amazonaws.com/NRHPpxtf6ZFa3kiaJaX3rW https://cassyni.com/events/DXz63DSdBFjkigMEKqSFbj?videoPreview=1 Power BI Overviewnohttps://cassyni.com/events/DXz63DSdBFjkigMEKqSFbj?videoPreview=12026-03-12T14:00:00+00:003379.44Research Evaluation and Analytics Capacity Hub**1. Power BI Overview** **Level:** Introductory We will step back and map the landscape of Microsoft’s analytics tools, how they fit together, and where Power BI sits in the stack. - **Microsoft Analytics Stack Overview** - Why Microsoft is a strong option for lean teams. - **Core Concepts** - Data models - DAX - Calculated columns - Workspaces - Apps - Licensing - **Deployment Models** - Differences between **Power BI Desktop**, the **Power BI Service**, and **Apps** - When to use each option - **Example Workflow** - Building a report - Deploying it to end usershttps://cassyni-user-files-prod.s3.amazonaws.com/NRHPpxtf6ZFa3kiaJaX3rW https://cassyni.com/events/Lwjmr6fPAUyKMja6aHEReM/seminar/qa https://cassyni.com/slides/outline/Lwjmr6fPAUyKMja6aHEReM https://cassyni.com/events/Lwjmr6fPAUyKMja6aHEReM/abstract https://cassyni-user-files-prod.s3.amazonaws.com/PU6x5ArhjseQyoXt2bk4qU https://cassyni.com/events/Lwjmr6fPAUyKMja6aHEReM?videoPreview=1 Epidemiology of Midlife Obesity – Global Trends, Risk factors and Emerging Pharmacological Interventionsnohttps://cassyni.com/events/Lwjmr6fPAUyKMja6aHEReM?videoPreview=12026-05-01T14:00:00+00:002691.36Women's Health"Midlife is a pivotal stage for women’s health, yet obesity in this group has increased dramatically across the United States. Our study shows that if current trends continue, more than four in five women aged 40–64 could be living with overweight or obesity by 2050. Understanding these trajectories is essential for designing targeted prevention strategies and reducing long-term chronic disease risk." - Dr Akshaya Bhagavathula, Guest Editor of the Special Collectionhttps://cassyni-user-files-prod.s3.amazonaws.com/PU6x5ArhjseQyoXt2bk4qU https://cassyni.com/events/Wq1i2hGdNcEdpopPBvvyxH/abstract https://cassyni-user-files-prod.s3.amazonaws.com/CPtz1dfTmuocNP85paNTtr https://cassyni.com/slides/outline/3fMUV6gmERn9dCHsCvYXGR https://cassyni.com/events/3fMUV6gmERn9dCHsCvYXGR/abstract https://cassyni-user-files-prod.s3.amazonaws.com/LydjaP1pVszAh1fnuMHH9G https://cassyni.com/events/3fMUV6gmERn9dCHsCvYXGR?videoPreview=1 Social Justice and the Humanities and Social Sciencesnohttps://cassyni.com/events/3fMUV6gmERn9dCHsCvYXGR?videoPreview=12021-09-16T08:00:00+00:003716.2Palgrave MacmillanThis seminar addresses the critical role of the humanities and social sciences in advancing social justice within the framework of the United Nations Sustainable Development Goals (SDGs). Emphasizing the importance of interdisciplinary research, the discussion highlights how academic publishing, particularly through Palgrave Macmillan and Springer Nature, supports scholarship that engages with global challenges such as inequality, climate change, and health disparities. The analysis underscores the need for academia to better document and incentivize societal impact, proposing frameworks for tracking contributions beyond traditional metrics, including qualitative case studies and grey literature indexing. A case study on SDG 4.7—education for sustainable development—illustrates gaps in integrating justice and sustainability into curricula, using the Bhopal gas tragedy as an example of missed opportunities for ecological literacy and social inclusion in education. The seminar advocates for localized, interdisciplinary approaches involving diverse stakeholders—ranging from government departments to community members and educators—to foster lifelong learning and civic engagement. Furthermore, it stresses the humanities and social sciences’ unique capacity to contextualize scientific knowledge within social, cultural, and political dimensions, thereby enriching understanding of complex issues such as racism, inequality, and climate justice. Publishing initiatives are also described that aim to amplify marginalized voices and promote diversity, equity, and inclusion within academic discourse. Overall, the seminar calls for enhanced collaboration between researchers, policymakers, and communities to ensure that scholarly work effectively contributes to equitable and sustainable societal transformation.https://cassyni-user-files-prod.s3.amazonaws.com/LydjaP1pVszAh1fnuMHH9G https://cassyni.com/events/MSirGLVYSGe8nkosUUHazZ/abstract https://cassyni-user-files-prod.s3.amazonaws.com/SpikzBTUsCm37cyX1suygi https://cassyni.com/events/HzBcwYxsN4mVm4WJpoudTj/seminar/qa https://cassyni.com/slides/outline/HzBcwYxsN4mVm4WJpoudTj https://cassyni.com/events/HzBcwYxsN4mVm4WJpoudTj/abstract https://cassyni-user-files-prod.s3.amazonaws.com/RDx772svKS22tHHH3S3AAr https://cassyni.com/events/HzBcwYxsN4mVm4WJpoudTj?videoPreview=1 Correspondence Problems for Classes of Postlinear Ordersnohttps://cassyni.com/events/HzBcwYxsN4mVm4WJpoudTj?videoPreview=12025-12-17T15:00:00+00:003846.04Logica UniversalisWe examine the definability and correspondence problems between the first-order language of order and the propositional language when given intuitionistic Kripke semantics. Our results are concerning classes of frames for the superintuitionistic logic. The frames for LC are those partial orders in which every principal upper cone is linearly ordered – we call such orders postlinear and denote by PL the class of all postlinear orders. We prove that the monadic second-order theory of the class of countable postlinear orders is decidable and consequently that the definability and correspondence problems modulo finitely axiomatizable subclasses of PL are decidable. https://cassyni-user-files-prod.s3.amazonaws.com/RDx772svKS22tHHH3S3AAr https://cassyni.com/slides/outline/XKgwC1S3DRiTeGotz33x8V https://cassyni.com/events/XKgwC1S3DRiTeGotz33x8V/abstract https://cassyni-user-files-prod.s3.amazonaws.com/4FPnmZj3xDhspEHDifgEfQ https://cassyni.com/events/XKgwC1S3DRiTeGotz33x8V?videoPreview=1 Laser-driven wakefield accelerators: electron beams for fundamental and applied researchnohttps://cassyni.com/events/XKgwC1S3DRiTeGotz33x8V?videoPreview=12026-03-19T15:00:00+00:002833.44Journal of Plasma PhysicsLaser-driven wakefield accelerators constitute a powerful platform for generating secondary radiation and particle beams with exceptional spatiotemporal properties (typically at the micrometer and femtosecond scales) and peak brightness. These distinctive characteristics offer unique opportunities to probe and manipulate matter across multiple fundamental scales, from nuclear and particle physics to chemical and biological systems. The intrinsic flexibility of laser–plasma interactions allows precise control over beam parameters and, by tailoring the interaction conditions, selective production of different particle and radiation soruces, including x-rays, gamma rays, electrons, positrons, and muons. For example, the coupling of laser-wakefield–accelerated electron beams with ultra-intense laser fields has recently opened access to previously unexplored regimes of strong-field quantum electrodynamics. This progress has culminated in the observation of quantum effects in radiation reaction and underpins forthcoming experimental efforts aimed at realising laboratory studies of Breit–Wheeler pair production in both the linear and nonlinear regimes. Beyond fundamental physics, proof-of-principle experiments have demonstrated the significant potential of plasma-based accelerators in many interdisciplinary areas such as radiobiology, materials science, and advanced collider concepts. In this talk, we present an overview of recent advances in the application of laser-wakefield–accelerated electron beams to both fundamental and applied research, highlighting the versatility, scalability, and transformative potential of plasma-based accelerator technology. https://cassyni-user-files-prod.s3.amazonaws.com/4FPnmZj3xDhspEHDifgEfQ https://cassyni.com/events/Ts9hsDuN9DqpcaWLLNfzbf/seminar/qa https://cassyni.com/slides/outline/Ts9hsDuN9DqpcaWLLNfzbf https://cassyni.com/events/Ts9hsDuN9DqpcaWLLNfzbf/abstract https://cassyni-user-files-prod.s3.amazonaws.com/WDUTJmNC79Puv1nJsN59CJ https://cassyni.com/events/Ts9hsDuN9DqpcaWLLNfzbf?videoPreview=1 Model reduction and control of Flows over complex and responsive Surfacesnohttps://cassyni.com/events/Ts9hsDuN9DqpcaWLLNfzbf?videoPreview=12026-03-18T14:00:00+00:003645.36Department of AeronauticsFlows over complex surfaces exhibit rich physics that offer opportunities for control—such as drag reduction or heat transfer enhancement—but can also lead to detrimental effects like increased drag from roughness or contamination by bacterial biofilms. In some systems, surfaces (such as rough or porous materials) passively modify momentum transfer without being significantly affected by the flow. In others, including bacterial biofilms or lubricated walls, the surface evolves dynamically under flow, resulting in strong coupling and feedback between surface and flow. This talk presents recent progress toward reduced-order and data-driven models that efficiently capture these interactions. For passive surfaces, homogenization and machine-learning approaches are used to represent their effective influence on the flow. For responsive surfaces, models describe and eventually enable control of the coupled surface–flow evolution. Together, these advances provide new ways for predicting and controlling flow–surface interactions across physical and biological systems.https://cassyni-user-files-prod.s3.amazonaws.com/WDUTJmNC79Puv1nJsN59CJ https://cassyni.com/events/D3JrsuHDLSFvuDMiXjKHRX/abstract https://cassyni-user-files-prod.s3.amazonaws.com/2zD4D2L7AGrJHGbsHTjFup https://cassyni.com/slides/outline/Aa85sk5MwsLwWT3BUHBGF7 https://cassyni.com/events/Aa85sk5MwsLwWT3BUHBGF7/abstract https://cassyni-user-files-prod.s3.amazonaws.com/SsXzJCYMMLkjA4eAhK4rwg https://cassyni.com/events/Aa85sk5MwsLwWT3BUHBGF7?videoPreview=1 Heat manipulation based on symmetry considerationsnohttps://cassyni.com/events/Aa85sk5MwsLwWT3BUHBGF7?videoPreview=12026-05-19T13:00:00+00:003869.48MetaMATHeat manipulation is vital in energy, information, medical and other technologies. Thermal metamaterials have shown great potential to control the heat flow in artificial structures. In this talk, I will report some results in this field based on different kinds of symmetries and their breaking: thermal topological theory based on spatial symmetry, thermal non-Hermitian theory based on spacetime (PT) symmetry, thermal scattering theory based on reciprocity, and operator-learning method based on time-reversal asymmetry. These theories and methods show possibilities of localized heat dissipation, heat locking, heat circulation, and thermal field retrodiction, indicating new directions in thermal management and information.https://cassyni-user-files-prod.s3.amazonaws.com/SsXzJCYMMLkjA4eAhK4rwg https://cassyni.com/slides/outline/C41enXzATX9nETXiRkqxcd https://cassyni.com/events/C41enXzATX9nETXiRkqxcd/abstract https://cassyni-user-files-prod.s3.amazonaws.com/EzVVVkRb7hsdBZynvz4eJi https://cassyni.com/events/C41enXzATX9nETXiRkqxcd?videoPreview=1 Session 2B: Hydrogen from Natural Gas (Methane)nohttps://cassyni.com/events/C41enXzATX9nETXiRkqxcd?videoPreview=12025-10-21T07:30:00+00:005853.2Centre for Energy TechnologyThis seminar session critically examines methane pyrolysis as a promising pathway for hydrogen production from natural gas, emphasizing its potential to decarbonize energy systems while generating valuable solid carbon co-products. The discussion highlights dry methane splitting technologies that dissociate methane into hydrogen and solid carbon without CO2 emissions, contrasting with conventional combustion processes. Key approaches include catalytic and thermal methods, such as Carbotopia’s low-temperature catalytic vapor deposition and 1414 Degrees’ dual-column reactor integrating renewable thermal energy storage with molten catalysts. Experimental data demonstrate methane conversions up to 70% at temperatures around 1100°C, producing hydrogen-rich gas streams suitable for blending into existing natural gas infrastructure, enabling partial decarbonization without extensive retrofitting. The solid carbon byproduct, characterized by diverse morphologies and high surface area, offers applications in soil enhancement, battery anodes, and advanced materials, contributing to circular economy goals. Challenges identified encompass political and market barriers, knowledge gaps, carbon handling complexities, and the need for standardized carbon accounting frameworks, with ongoing efforts to develop ISO standards for emissions calculation. The integration of methane pyrolysis with renewable electricity and existing gas networks presents a scalable, cost-competitive alternative to water electrolysis, particularly for hard-to-electrify sectors such as heavy industry. The session underscores the importance of collaborative strategies to overcome institutional resistance and accelerate technology readiness, aiming for commercial deployment by 2030. Overall, methane pyrolysis emerges as a viable component of diversified hydrogen economies, aligning with multiple sustainable development goals and offering pathways for negative emissions through industrial carbon removals.https://cassyni-user-files-prod.s3.amazonaws.com/EzVVVkRb7hsdBZynvz4eJi https://cassyni.com/slides/outline/NRexsX655VhvuSXFjRjHvm https://cassyni.com/events/NRexsX655VhvuSXFjRjHvm/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Y9oHQkvCjNgHMSwN8mzCbQ https://cassyni.com/events/NRexsX655VhvuSXFjRjHvm?videoPreview=1 Session 5B: Photo-electrochemical (PEC) and Photocatalysis (PC)nohttps://cassyni.com/events/NRexsX655VhvuSXFjRjHvm?videoPreview=12025-10-23T06:00:00+00:007061.84Centre for Energy TechnologyThis seminar session critically examined advances and challenges in photoelectrochemical (PEC) and photocatalytic (PC) water splitting technologies for solar hydrogen and solar fuels production. Emphasis was placed on integrating light absorption and electrolysis to enable direct solar-to-hydrogen conversion, contrasting conventional photovoltaic-electrolyzer systems with integrated PEC and particulate photocatalytic approaches. Experimental developments highlighted include silicon–perovskite tandem solar cells interfaced with proton exchange membrane (PEM) electrolyzers, achieving solar-to-hydrogen efficiencies up to 8% with innovative thermal management via 3D-printed heat exchangers, and stable outdoor operation over multiple days. The coupling of PEC hydrogen generation with bioreactors demonstrated solar-to-methane conversion at a global solar-to-fuel yield of 5.5%. Parallel research explored novel semiconductor materials such as halide perovskites and organic bulk heterojunctions, addressing their intrinsic instability in aqueous electrolytes through protective carbon-based catalytic sheets (graphite, glassy carbon, boron-doped diamond), achieving photocurrents exceeding 20 mA cm⁻² and unassisted solar-to-hydrogen efficiencies above 5%. The session also addressed the innovation ecosystem, focusing on the European Innovation Council’s funding mechanisms spanning fundamental research to market-ready prototypes, emphasizing techno-sustainability assessments and the need for standardized testing protocols to build investor confidence. Panel discussions underscored the critical balance between cost, stability, scalability, and sustainability, highlighting the importance of collaborative infrastructures, international cooperation, and novel financing models to bridge the gap from laboratory research to commercial deployment. The integration of multidisciplinary expertise and strategic policy support was identified as essential for accelerating the transition to sustainable solar fuel technologies.https://cassyni-user-files-prod.s3.amazonaws.com/Y9oHQkvCjNgHMSwN8mzCbQ https://cassyni.com/events/HVAvQgcpgvAuWLouix2JCd/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Q3hkyxzHpifRHhzpywZLQW https://cassyni.com/events/YJd3oC2ZrenFkxXHEzVf4h/abstract https://cassyni-user-files-prod.s3.amazonaws.com/7RnbgfMrmLgq1TLfggizZc https://cassyni.com/slides/outline/Qttz6wKhGnUjzvLNgpt2cd https://cassyni.com/events/Qttz6wKhGnUjzvLNgpt2cd/abstract https://cassyni-user-files-prod.s3.amazonaws.com/SU8TPXKyqm1Eed89tXFjB4 https://cassyni.com/events/Qttz6wKhGnUjzvLNgpt2cd?videoPreview=1 SSP Innovation Showcase (Winter 2024)nohttps://cassyni.com/events/Qttz6wKhGnUjzvLNgpt2cd?videoPreview=12024-02-22T06:00:00+00:003636.76SSP Society for Scholarly PublishingJoin us for a free webinar highlighting new and exciting industry innovations. Speakers will present their solutions in brief presentations and take your questions. Don’t miss this opportunity to learn about developments in the industry.https://cassyni-user-files-prod.s3.amazonaws.com/SU8TPXKyqm1Eed89tXFjB4 https://cassyni.com/slides/outline/PugeMTaJbx9QN95e5ahXgZ https://cassyni.com/events/PugeMTaJbx9QN95e5ahXgZ/abstract https://cassyni-user-files-prod.s3.amazonaws.com/D5CcqrZuzfRJXnrP9ZkrJi https://cassyni.com/events/PugeMTaJbx9QN95e5ahXgZ?videoPreview=1 “Aria” Interview: Cross-silo Collaborationsnohttps://cassyni.com/events/PugeMTaJbx9QN95e5ahXgZ?videoPreview=12021-02-11T06:00:00+00:00166.64Hong Kong Baptist UniversityToday when face-to-face interaction has become almost impossible, how do local and overseas artists keep working together to address social issues in an aesthetically interesting way?https://cassyni-user-files-prod.s3.amazonaws.com/D5CcqrZuzfRJXnrP9ZkrJi https://cassyni.com/events/86rSXhKrMDeMbGmSKDCMeM/seminar/qa https://cassyni.com/slides/outline/86rSXhKrMDeMbGmSKDCMeM https://cassyni.com/events/86rSXhKrMDeMbGmSKDCMeM/abstract https://cassyni-user-files-prod.s3.amazonaws.com/415RFAuyfj9HaexnC4Kxw8 https://cassyni.com/events/86rSXhKrMDeMbGmSKDCMeM?videoPreview=1 Controllable Visual Imaginationnohttps://cassyni.com/events/86rSXhKrMDeMbGmSKDCMeM?videoPreview=12026-02-20T18:00:00+00:003214.76School of Data ScienceGenerative models have empowered human creators to visualize their imaginations without artistic skills and labor. A prominent example is large-scale text-to-image/video generation models. However, these models are often difficult to control and do not respect 3D perspective geometry and the temporal consistency of videos. In this talk, I will showcase several of our recent efforts to improve controllability for visual imagination. Specifically, I will discuss how we enable semantic and spatial control for 2D image generation, facilitate layered decompositions for video editing, and synthesize object and camera motions from monocular videos. https://cassyni-user-files-prod.s3.amazonaws.com/415RFAuyfj9HaexnC4Kxw8 https://cassyni.com/events/49kUW7hK3dzkf75b4TAoQh/seminar/qa https://cassyni.com/slides/outline/49kUW7hK3dzkf75b4TAoQh https://cassyni.com/events/49kUW7hK3dzkf75b4TAoQh/abstract https://cassyni-user-files-prod.s3.amazonaws.com/B7sArsQGCGvZJoJHzVM1MQ https://cassyni.com/events/49kUW7hK3dzkf75b4TAoQh?videoPreview=1 ARC Fusion Power Plant Physics Basisnohttps://cassyni.com/events/49kUW7hK3dzkf75b4TAoQh?videoPreview=12026-06-04T15:00:00+00:003299.6Journal of Plasma PhysicsCommonwealth Fusion Systems plans to build ARC as the first fusion power plant at a site in Chesterfield County, Virginia, USA by the early 2030's. Across a collection of 5 papers, we present an overview of analysis comprising the physics basis of the ARC V3A design, a high magnetic field tokamak with $B_0=11.4 \ T$, $I_p=12.0 \ MA$, $R_0=4.62 \ m$, $a=1.18 \ m$. ARC V3A is designed to produce $P_{fus} \approx 1.13$ GW DT fusion power and deliver $\geq$ 400 MW net electric power to the grid. This talk includes summaries of the overview paper covering quantitative analysis of fundamental issues for design of and operational plasma scenarios for a tokamak power plant, and that lays out the design targets and strategic choices for ARC, and of the topical papers on fusion performance and transport, disruption physics, boundary physics, and MHD stability. Critically, these studies identify key model uncertainties and physics risks to be retired through SPARC operation.https://cassyni-user-files-prod.s3.amazonaws.com/B7sArsQGCGvZJoJHzVM1MQ https://cassyni.com/slides/outline/2fio2BD5XBZHCQXCiJCZeu https://cassyni.com/events/2fio2BD5XBZHCQXCiJCZeu/abstract https://cassyni-user-files-prod.s3.amazonaws.com/P8L14wYhmB4Cxd12SihcmC https://cassyni.com/events/2fio2BD5XBZHCQXCiJCZeu?videoPreview=1 Data-Driven Modeling of Turbulent Flows: Stochastic Koopman Models and Nonlinear Modal Energeticsnohttps://cassyni.com/events/2fio2BD5XBZHCQXCiJCZeu?videoPreview=12026-03-02T19:30:00+00:003736.76AI Institute in Dynamic SystemsPredictive, reduced-order models for turbulent flows must confront two core difficulties: the dynamics are strongly nonlinear and multi-scale, and the resulting trajectories are only predictable over limited horizons, even when the governing equations are known. In this talk I will present two complementary data-driven advances that address these issues from different angles: (i) stable, uncertainty-aware forecasting with a stochastic Koopman reduced-order model, and (ii) an interpretable decomposition that reveals where, how, and between which structures nonlinear energy transfer occurs. On the modeling side, I will outline the stochastic low-dimensional inflated convolutional Koopman (SLICK) model, which evolves SPOD-based convolutional (time-delay) coordinates with a finite-dimensional Koopman operator and closes unresolved nonlinear interactions by augmenting the state and modeling the residual as a stochastic source. To complement forecasting with mechanism, I will then introduce Triadic Orthogonal Decomposition (TOD), which identifies coherent structures that optimally capture spectral momentum transfer, ranks and quantifies triadic coupling via an energy-budget bispectrum, and distinguishes recipient, donor, and catalyst roles while localizing interaction regions (shown for the cylinder wake, wind-turbine wake data, and isotropic turbulence). Together, these two results illustrate a theme for realistic turbulent flows: data-driven reduced-order modeling that is both predictive and physically interpretable through nonlinear energy-transfer structure.https://cassyni-user-files-prod.s3.amazonaws.com/P8L14wYhmB4Cxd12SihcmC https://cassyni.com/slides/outline/CYgswr9aJLdc3vXEDrxvnq https://cassyni.com/events/CYgswr9aJLdc3vXEDrxvnq/abstract https://cassyni-user-files-prod.s3.amazonaws.com/P8h2su3BY895xv4ZX8LfjU https://cassyni.com/events/CYgswr9aJLdc3vXEDrxvnq?videoPreview=1 CRediT Where it's Due? (Lightning Talk)nohttps://cassyni.com/events/CYgswr9aJLdc3vXEDrxvnq?videoPreview=12026-02-24T11:30:00+00:00287.56Researcher to ReaderScientific discovery is increasingly done by large teams and across different disciplines making clear attribution essential. IOP Publishing has implemented the Contributor Role Taxonomy (CRediT) across all its propriety journals, enabling authors to define their roles and ensure transparency. Learn how this change enhances fairness, accountability, and recognition in research publishing.https://cassyni-user-files-prod.s3.amazonaws.com/P8h2su3BY895xv4ZX8LfjU https://cassyni.com/slides/outline/PQyo5Wu1Mmjoig3f7y94NH https://cassyni.com/events/PQyo5Wu1Mmjoig3f7y94NH/abstract https://cassyni-user-files-prod.s3.amazonaws.com/GUSh4VLDqzn8EpTg5Mhhre https://cassyni.com/events/PQyo5Wu1Mmjoig3f7y94NH?videoPreview=1 B5 – Data-Driven Award Management: Turning Reporting & Analytics into Actionnohttps://cassyni.com/events/PQyo5Wu1Mmjoig3f7y94NH?videoPreview=12026-04-20T10:15:00+00:002573.04Research Analytics SummitResearch administrators face increasing pressure to deliver accurate proposals quickly while maintaining compliance and transparency. Yet many pre – award reporting processes remain static, siloed, and reactive. This session explores how research offices are transforming reporting into actionable analytics that support real – time decision – making. Through a case study with a research institution using an integrated ERA and reporting framework, presenters will demonstrate how descriptive, predictive, and prescriptive analytics can improve visibility, forecasting, and workload management. The discussion will include practical steps for defining KPIs, integrating data across systems, and using analytics to strengthen sponsor relationships and compliance oversight. Attendees will leave with a framework to assess and enhance their own reporting strategies, regardless of their institution’s size or system maturity.https://cassyni-user-files-prod.s3.amazonaws.com/GUSh4VLDqzn8EpTg5Mhhre https://cassyni.com/slides/outline/KxSZkjNLHZsAgyk6UJm6qT https://cassyni.com/events/KxSZkjNLHZsAgyk6UJm6qT/abstract https://cassyni-user-files-prod.s3.amazonaws.com/UbSXD43mwheBbMQNBaSquY https://cassyni.com/events/KxSZkjNLHZsAgyk6UJm6qT?videoPreview=1 E1 – Beyond Reporting: How AI – Enabled Research Analytics Reveals Gaps, Risk, and Accountability in Research Administrationnohttps://cassyni.com/events/KxSZkjNLHZsAgyk6UJm6qT?videoPreview=12026-04-20T14:45:00+00:002375.92Research Analytics SummitResearch administration offices generate extensive analytics to support grant management, compliance, and external reporting. However, many analytics practices remain focused on reporting activity rather than supporting judgment, readiness, and institutional decision – making. As expectations increase, strong performance metrics can still obscure gaps, unmonitored risk, and unverified assumptions. This session explores how AI – enabled research analytics can move institutions beyond reporting toward a diagnostic, decision – support approach. AI is framed as an analytical assistant, augmenting existing workflows by helping identify missing or inconsistent data, surface early risk signals, and support clearer interpretation of trends. The session introduces a practical Gap–Risk–Accountability framework that research administrators can use to assess whether their analytics are truly decision – ready. Illustrative examples from research administration contexts, including institutions experiencing rapid research growth such as Morgan State University, demonstrate how strong activity indicators (e.g. grant growth) can coexist with unseen vulnerabilities. Research administrators and research analytics professionals will gain actionable takeaways, including how to distinguish reporting from decision – support analytics, identify hidden gaps and risk, apply responsible human – in – the – loop AI – assisted checks, and ask stronger questions of dashboards, using scalable practices.https://cassyni-user-files-prod.s3.amazonaws.com/UbSXD43mwheBbMQNBaSquY https://cassyni.com/slides/outline/WL4Fj5xMWBVbDV3EVQhzWy https://cassyni.com/events/WL4Fj5xMWBVbDV3EVQhzWy/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Qwgy1CyZBqaCNkPFw9z7r6 https://cassyni.com/events/WL4Fj5xMWBVbDV3EVQhzWy?videoPreview=1 G3 – the No One Size Fits All Approach to Implementing Research Analyticsnohttps://cassyni.com/events/WL4Fj5xMWBVbDV3EVQhzWy?videoPreview=12026-04-21T10:15:00+00:002824.32Research Analytics SummitSeeking attendees that wish to advance their understanding of research analytics and the implementation of AI, systems and technology, and responsible evaluation practices to streamline research administration through data – informed decision making at your institution. A panel discussion will present four different institutional perspectives – Ontario Tech University (Canadian University), Unity Health Toronto (Hospital Research Institute), Emory University (US University) and Northeastern University (US University) – with the goal to encourage attendees to provide additional institutional perspectives. The session will be highly interactive (open discussion, live polling) with the goal of the session to advance the research analytics community of practice. Presenters will illustrate use cases/perspectives/solutions from their institutions. Participants from the REACH network will benefit from the session through increased understanding of research analytics, AI and responsible evaluation practices which can be adapted at their own institutions; exploration of how AI and technology can be used to streamline research administration; and increased knowledge of best practices, resources, and networks to support institutional and individual capacity building (e.g. REACH network).https://cassyni-user-files-prod.s3.amazonaws.com/Qwgy1CyZBqaCNkPFw9z7r6 https://cassyni.com/slides/outline/68HeTbFdzkMh3oHPZdQh6d https://cassyni.com/events/68HeTbFdzkMh3oHPZdQh6d/abstract https://cassyni-user-files-prod.s3.amazonaws.com/7YkgigiAaVp4dew5JufwQ2 https://cassyni.com/events/68HeTbFdzkMh3oHPZdQh6d?videoPreview=1 PropTech Pitching Competition 2026nohttps://cassyni.com/events/68HeTbFdzkMh3oHPZdQh6d?videoPreview=12026-03-27T05:30:00+00:00224.08Business SchoolThe PropTech Pitching Competition provides students with the opportunity topitch a PropTech solution for an identified problem in the property market. Students fromBProp’s PropTech course 2025 (PROP384) and MPP’s PropTech course 2025(PROPPRAC707) have been given one semester / one quarter period to develop a proposal.The best two or three performing teams from each course are invited to pitch their furtherdeveloped ideas to a panel of judges to select the best pitching team from each course. TheBProp case aims to propose a solution for the accountability of Automated Valuation Model(AVM) estimates in compliance with the latest International Valuation Standards (IVS,2025). The MPP case, on the other hand, seeks to propose a solution to their self-identifiedproblems in property markets. Pitching Teams: 1. PROP384@2025 - Jeff He, Syon Kapoor, Emanuela Sepetavc, 2. PROPPRAC707@2025 - Mele Havea, Marcus Reinders, Nermeen Haroun, Jonnel Mamauag Judging Panel Members: Matt Tooman, James Costello, Dehardt van der Merwe Masters of Ceremony: Nico Cheifetz (Education Vice-President) & Obaidullah Buksh (Education Officer) of Auckland University Property Student Society (AUPSS) https://www.linkedin.com/posts/yiued2022_uabs-proptech-pitching-competition-2026-activity-7437577627881705473-fVaO?utm_source=share&utm_medium=member_desktop&rcm=ACoAAAIWUlABqGOJx4qxDcuaXhdYpsWx6C0GUL4https://cassyni-user-files-prod.s3.amazonaws.com/7YkgigiAaVp4dew5JufwQ2 https://cassyni.com/slides/outline/8bXfh1VGC38BQjkx7KKKpZ https://cassyni.com/events/8bXfh1VGC38BQjkx7KKKpZ/abstract https://cassyni-user-files-prod.s3.amazonaws.com/KfvouRwox5s5JCKpNboPUz https://cassyni.com/events/8bXfh1VGC38BQjkx7KKKpZ?videoPreview=1 Being Human Speakers: What would the world be like without the humanities?nohttps://cassyni.com/events/8bXfh1VGC38BQjkx7KKKpZ?videoPreview=12018-10-05T06:00:00+00:0069.64NoneIn 2017 we teamed up with Being Human, a national festival dedicated to demonstrating the breadth, diversity and vitality of the humanities, led by the School of Advanced Study, University of London in partnership with the Arts & Humanities Research Council and the British Academy. We hosted a lively panel discussion which examined the evolution of gay, lesbian and queer representation across history, literature and media. Our panellists delved into what it has meant to be a ‘lost’, marginalised and even criminalised voice, and examined to what degree historically marginalised voices have been ‘found’ since this momentous Act of Parliament was passed.https://cassyni-user-files-prod.s3.amazonaws.com/KfvouRwox5s5JCKpNboPUz https://cassyni.com/slides/outline/3f3dEB21oTbA1e3c6qcL6R https://cassyni.com/events/3f3dEB21oTbA1e3c6qcL6R/abstract https://cassyni-user-files-prod.s3.amazonaws.com/WBBFr3Fps8XgJKfbW2q9dg https://cassyni.com/events/3f3dEB21oTbA1e3c6qcL6R?videoPreview=1 Exploration of Cathode Materials for High-Performance Li-S Batteriesnohttps://cassyni.com/events/3f3dEB21oTbA1e3c6qcL6R?videoPreview=12026-05-20T14:00:00+00:002204.16Connecting Science, Publishing, and InnovationRecently, a lot of efforts have been devoted into lithium-sulfur (Li-S) battery system due to its high theoretical capacity (1675 mAh g-1) and low cost, which could be a competitive candidate for the next-generation batteries in the future. However, it suffers from a poor cycling stability during charging-discharging, which is blamed to the “shuttle effects” of lithium polysulfides. Fundamental understanding of the formation and dissolution processes of both solid phases, S8 and Li2S, is necessary for the development of advanced cathode materials with improved electrochemical performance. Using colloidal route, complex hybrid carbon nanostructures have been synthesized using colloidal polymeric particle as soft template, which have been applied as cathode materials for Li-S batteries. Synchrotron-based operando high-resolution X-ray imaging has been successfully used for the detailed morphology study of sulfur particles during cycling of the battery cells. Moreover, cryo-TEM has been applied to reveal sensitive electrochemical materials and interfaces, e.g., Li metal and SEI.https://cassyni-user-files-prod.s3.amazonaws.com/WBBFr3Fps8XgJKfbW2q9dg https://cassyni.com/slides/outline/HysmgdJ7w6aW9WG3iiySHj https://cassyni.com/events/HysmgdJ7w6aW9WG3iiySHj/abstract https://cassyni-user-files-prod.s3.amazonaws.com/xp9YSPb5JGbxeQxhEnu6N https://cassyni.com/events/HysmgdJ7w6aW9WG3iiySHj?videoPreview=1 Episode 5: Conversation with Charles Raisonnohttps://cassyni.com/events/HysmgdJ7w6aW9WG3iiySHj?videoPreview=12025-10-23T13:00:00+00:002349.64Advanced ScienceA great conversation on the evolving role of psychedelics in cancer care with Charles L. Raison (University of Wisconsin–Madison). https://cassyni-user-files-prod.s3.amazonaws.com/xp9YSPb5JGbxeQxhEnu6N https://cassyni.com/slides/outline/Ur94hfXfbAkyfn65LGD8EZ https://cassyni.com/events/Ur94hfXfbAkyfn65LGD8EZ/abstract https://cassyni-user-files-prod.s3.amazonaws.com/2D8x4nDMJ2YhUMpjs7GteS https://cassyni.com/events/Ur94hfXfbAkyfn65LGD8EZ?videoPreview=1 A Lung‐Immune Dual‐Humanized Mouse Using Cryopreserved Tissue Enables Infection and Immune Profiling of Human Common Cold Coronavirusesnohttps://cassyni.com/events/Ur94hfXfbAkyfn65LGD8EZ?videoPreview=12026-05-07T12:00:00+00:001644.36Advanced ScienceHuman common cold coronaviruses (CCCoVs; e.g., 229E, NL63, OC43, HKU1) hold critical yet underexplored significance in understanding coronavirus evolutionary dynamics and immune cross-protection, offering insights for predicting emerging pathogens and developing pan-coronavirus vaccines. However, research is hindered by the lack of animal models due to strict human-specific tropism and the confounding effects of frequent co-infections from clinical samples, which obscure virus-specific pathogenesis. Although lung-humanized mice have been used in SARS-CoV-2 studies, their application to CCCoVs remains unvalidated and relies on logistically challenging fresh human tissues. This study optimizes a transplantation strategy using cryopreserved human fetal lung tissue, achieving enhanced engraftment efficiency. And the refined model supports robust infection by all four major CCCoVs and demonstrates the therapeutic efficacy of Paxlovid against HKU1. Furthermore, comparative analysis reveals phenotypic distinctions in human immune cells between native mouse lungs and human lung implants in lung-immune dual-humanized mice. The model also enables validation of virus-specific T cell responses and assessment of SARS-CoV-2 cross-reactivity post-HKU1 infection. Overall, this study establishes a scalable platform using cryopreserved tissues for respiratory virus research, overcoming prior limitations in modeling human-specific tropism and dissecting immune-pathogen interactions.https://cassyni-user-files-prod.s3.amazonaws.com/2D8x4nDMJ2YhUMpjs7GteS https://cassyni.com/slides/outline/XKP5w5mHnTXU2iZdsx7kxV https://cassyni.com/events/XKP5w5mHnTXU2iZdsx7kxV/abstract https://cassyni-user-files-prod.s3.amazonaws.com/LAaQx7bLPYRDeQP9oEseJr https://cassyni.com/events/XKP5w5mHnTXU2iZdsx7kxV?videoPreview=1 Being Human 2020 – Ethical Futures for a New World?nohttps://cassyni.com/events/XKP5w5mHnTXU2iZdsx7kxV?videoPreview=12020-12-14T09:00:00+00:001968.0NoneThe seminar explored the complex challenges and possibilities for constructing ethical futures in a world shaped by the global pandemic and movements like Black Lives Matter. Discussions highlighted the prevalence of digital harm, harassment, and abuse, particularly affecting Black women online, and underscored that oppressions such as racism, sexism, and classism are interconnected, necessitating integrated policy and legislative responses. In the Global South, the promise of digital technologies is tempered by issues of digital illiteracy, high access costs, limited infrastructure, and concerns about digital coloniality, where global companies operate without clear frameworks for data consent. Data journalism initiatives, while emerging, are impeded by a lack of governmental data, ethical concerns regarding consent, and the absence of freedom of information acts in certain non-democratic states. A further critical perspective was offered on the dominance of economic language and metrics in public debate and policymaking, contrasting with the intrinsic value of human life. The humanities are posited as essential for challenging neoliberal governance and re-evaluating societal values beyond economic terms, advocating for a future focused on diverse human flourishing. Addressing persistent anti-black racism in the United States, the concept of Black humanism was presented as an alternative to traditional, outcome-driven strategies. This approach emphasizes human accountability and responsibility, drawing value from the continuous, persistent effort to resist injustice, rather than solely measuring success by final outcomes. Collectively, the analyses stress the imperative to shift from commercial profit motives towards prioritizing people, social connections, and community engagement to foster genuinely equitable and ethical new worlds.https://cassyni-user-files-prod.s3.amazonaws.com/LAaQx7bLPYRDeQP9oEseJr https://cassyni.com/slides/outline/77cUfb4aH2PZs2onxApTY9 https://cassyni.com/events/77cUfb4aH2PZs2onxApTY9/abstract https://cassyni-user-files-prod.s3.amazonaws.com/42P7APYSoYZaNTPSsyurez https://cassyni.com/events/77cUfb4aH2PZs2onxApTY9?videoPreview=1 Manager Identity and the Workplacenohttps://cassyni.com/events/77cUfb4aH2PZs2onxApTY9?videoPreview=12025-11-19T14:00:00+00:001071.12Center for Black Entrepreneurship, Spelman CollegePervasive discrimination against Black job seekers in US companies necessitates interventions to mitigate biased hiring practices. Black hiring managers consistently hire Black individuals at higher rates, highlighting a critical role for workplace leaders in influencing talent evaluation. With Black-owned businesses experiencing a 33% increase in employee growth since 2012, their expanding role in the labor market makes this area particularly salient. This research agenda examines how Black business leaders influence hiring decisions and whether their presence can disrupt discriminatory patterns, addressing a gap in research on effective interventions despite extensive documentation of employer discrimination. An initial experimental phase investigated whether the race or gender of an HR supervisor affected external screeners' evaluations of job applications. This pilot found no significant effect, redirecting the study's focus to the direct influence of the hiring manager. The ongoing experimental design, an audit study, recruits freelance screeners to evaluate fictitious entry-level job applications. The central intervention involves presenting screeners with a varied fictitious hiring manager profile (race and gender) before they assess candidates on shortlisting potential, predicted productivity, and likely offer amounts. Future experiments will further explore the impact of hiring manager identity (race, gender), how their stated values influence screener perceptions, and the combined effect of manager identity with firm-signaled Diversity, Equity, and Inclusion (DEI) values. Ultimately, this work aims to identify mechanisms by which managerial identity can disrupt systemic hiring bias and encourage Black entrepreneurship.https://cassyni-user-files-prod.s3.amazonaws.com/42P7APYSoYZaNTPSsyurez https://cassyni.com/slides/outline/JyCbtd74DNcNy3NJ56zXxR https://cassyni.com/events/JyCbtd74DNcNy3NJ56zXxR/abstract https://cassyni-user-files-prod.s3.amazonaws.com/3ZvMwfF3W34vPrd5MEdcN2 https://cassyni.com/events/JyCbtd74DNcNy3NJ56zXxR?videoPreview=1 Free‐Volume Regulation Enables Significantly Enhanced Electrical Breakdown via Short‐Chain Molecular Spatial‐Positioning Intercalation into Poly(vinylidene fluoride)nohttps://cassyni.com/events/JyCbtd74DNcNy3NJ56zXxR?videoPreview=12026-09-02T00:00:00+00:00282.92Advanced ScienceThe peculiar molecule-structural units with ferroelectric ordering render poly(vinylidene fluoride) (PVDF) a crucial functional polymer, but the existence of the free volume in PVDF (also for many other polymers) would interrupt the long-range molecule chains, leading to the declined electrical functionality (e.g. electric breakdown), and also the thermal, mechanical, and chain relaxation properties. Herein, to regulate the free volume for electrical tuning, a molecular spatial-positioning shimming strategy is developed in terms of intercalating shortchain molecules polyethylene wax (PE wax) into the spherulite gap region of PVDF. The PE wax/PVDF films are fabricated by a multi-layer folding coupled hot pressing route that allows the complex crystalline structure modulation (e.g. phase, morphology, spherulite formation, amorphous and free-volume status etc.) which are comprehensively investigated. Upon free volume regulation, the fabricated PE wax/PVDF film exhibits significantly improved breakdown strength (Eb= 735.1 MV/m). Meanwhile, ultrahigh energy density (32.67 J/cm3) and energy storage efficiency (78.02%) are synergistically achieved. With ultrafast energy release (t0.9=38.5 ns) and exceptional power density (138 MW/cm³), the charge-discharge performance competes favorably with leading polymer/hybrid-based films. This work offers a novel model to design new PVDF (or other polymer) based films with generating superior functionality.https://cassyni-user-files-prod.s3.amazonaws.com/3ZvMwfF3W34vPrd5MEdcN2 https://cassyni.com/events/FWgzgU6GYXf3zqu8U6XTXj/abstract https://cassyni-user-files-prod.s3.amazonaws.com/7fJdSGg7NwQriN3Pqv8pcn https://cassyni.com/events/PR7uefUSNaNSTN7WWeSbkZ/seminar/qa https://cassyni.com/slides/outline/PR7uefUSNaNSTN7WWeSbkZ https://cassyni.com/events/PR7uefUSNaNSTN7WWeSbkZ/abstract https://cassyni-user-files-prod.s3.amazonaws.com/W7mbBQGW6PpbMw6MxoAUfG https://cassyni.com/events/PR7uefUSNaNSTN7WWeSbkZ?videoPreview=1 Brain‐Computer Interface Training Fosters Perceptual Skills to Detect Errorsnohttps://cassyni.com/events/PR7uefUSNaNSTN7WWeSbkZ?videoPreview=12026-08-27T15:00:00+00:002199.76Advanced ScienceAccurate perception of subtle visuo-motor errors is essential for perceptual and sensorimotor learning, and supports timely corrective actions in precision-based task. However, conventional perceptual training, typically based on response-accuracy feedback, is limited in improving sensitivity to small, subtle errors. While prior approaches have focused on modulating sensory regions to enhance perceptual learning, we propose an alternative approach that targets a cognitive neural marker: the error positivity (Pe), a component of the error-related potential (ErrP) originating in the anterior cingulate cortex, a key decision- making region. We hypothesize that the Pe, which reflects conscious awareness of errors, serves as a modifiable neural correlate of error perception. In a five-day longitudinal study, we show that providing real-time feedback on the presence or absence of ErrPs during perceptual training accelerates perceptual learning at 3◦errors and enhances perceptual performance at 6◦errors without accelerating the learning rate, relative to behavioral training alone. These behavioral gains were accompanied by increase in Pe amplitude. Together, these findings offer new neurophysiological insights into the mechanisms of error perception, and establish ErrP-based brain-computer interface interventions as a promising approach for fostering perceptual learning in domains where detecting subtle errors is critical.https://cassyni-user-files-prod.s3.amazonaws.com/W7mbBQGW6PpbMw6MxoAUfG https://cassyni.com/events/G1PqxQmZni4ee1MGTsUbcq/abstract https://cassyni-user-files-prod.s3.amazonaws.com/3yypQUnCexE7JzucBcDgh4 https://cassyni.com/events/GWX2woBA5JN6nouMsE1Jfo/abstract https://cassyni-user-files-prod.s3.amazonaws.com/24Yk2vFqUUCZVDyqxihrj8 https://cassyni.com/events/F21mX9vrhiBEBNucfzQVMX/abstract https://cassyni-user-files-prod.s3.amazonaws.com/MEVP1L52fQrY7Q5H65G6Px https://cassyni.com/events/9at81dp5sg69nWfP55QhN5/seminar/qa https://cassyni.com/slides/outline/9at81dp5sg69nWfP55QhN5 https://cassyni.com/events/9at81dp5sg69nWfP55QhN5/abstract https://cassyni-user-files-prod.s3.amazonaws.com/C8pQyYyQCkzEqCqbUMxumY https://cassyni.com/events/9at81dp5sg69nWfP55QhN5?videoPreview=1 The role of interfacial adhesion in the in-service behaviour of flax and hemp compositesnohttps://cassyni.com/events/9at81dp5sg69nWfP55QhN5?videoPreview=12026-06-17T12:50:00+00:001211.6NoneThe increasing volume of decommissioned wind turbine blades highlights the need for sustainable, bio-based composite alternatives. Natural fibres, such as flax and hemp, coupled with bio-based thermoplastic matrices, offer a promising solution despite their inherent hydrophilic nature and susceptibility to moisture-induced plasticization. This study investigated the hydrothermal durability and the role of interfacial adhesion in UD flax and hemp composites with epoxy and Elium (Arkema 191X0/SA system) matrices, examining their suitability for outdoor applications. Specimens were produced via vacuum infusion and conditioned for three weeks to saturation at 0% RH, 50% RH, or 90% RH at 40°C. Mechanical characterisation was performed under tension. The inclusion of methacrylic acid (MAA) as an additive significantly improved interfacial adhesion in hemp-Elium composites, resulting in a 25% increase in tensile strength and a 27% increase in stiffness, attributed to the formation of covalent bonds. Weakly adhering systems, like hemp/Elium without MAA, exhibited a 22% stiffness decrease from dry to 50% RH and a 43% decrease from dry to 90% RH, with no strength increase at high humidity. In contrast, strongly adhering systems (e.g., Elium with MAA, or epoxy) showed less sensitivity to initial moisture absorption and up to a 30% tensile strength increase at high humidity, explained by polymer constraint and microfibril realignment. Overall stiffness drops (dry to 90% RH) were in the range of 40-43% for most systems. The specific E1 stiffness of flax and hemp composites (especially with epoxy or Elium+MAA) remained comparable to E-glass even at 90% RH. These findings indicate that bio-based composites with tailored interfacial adhesion can achieve performance comparable to conventional materials, making sustainable wind energy infrastructure feasible with appropriate barrier coatings.https://cassyni-user-files-prod.s3.amazonaws.com/C8pQyYyQCkzEqCqbUMxumY https://cassyni.com/events/QQMsWmjiSmdEBc59sgpVrm/abstract https://cassyni-user-files-prod.s3.amazonaws.com/8tp7kr8MdmcTXPkpg9zMtz https://cassyni.com/events/QQMsWmjiSmdEBc59sgpVrm?videoPreview=1 Top Five Tips for New Peer Reviewersnohttps://cassyni.com/events/QQMsWmjiSmdEBc59sgpVrm?videoPreview=12026-06-11T08:00:00+00:00184.52MultiPsych JournalListen to the Top Five Tips for New Peer Reviewers by MultiPsych Editorial Board Member Dr Khutaija Noor, Global Ambassador for the Foundation of Clinical Research at Harvard University.https://cassyni-user-files-prod.s3.amazonaws.com/8tp7kr8MdmcTXPkpg9zMtz https://cassyni.com/slides/outline/Xp5wD2Sb2dw4gBbcqZgEGm https://cassyni.com/events/Xp5wD2Sb2dw4gBbcqZgEGm/abstract https://cassyni-user-files-prod.s3.amazonaws.com/2kFPNoXh45bHLu7eky5mKU https://cassyni.com/events/Xp5wD2Sb2dw4gBbcqZgEGm?videoPreview=1 Hydraulic stress limits thermal acclimation in trees under chronic drought.nohttps://cassyni.com/events/Xp5wD2Sb2dw4gBbcqZgEGm?videoPreview=12026-06-03T12:25:00+00:00658.4The capacity of trees to withstand intensifying hot-drought events depends on coordination between hydraulic safety and leaf thermoregulation, yet the limits of this coordination under chronic stress remain poorly understood. Here, we show that five years of chronic soil moisture limitation fundamentally constrains leaf thermoregulation. We studied two temperate tree species with contrasting water-use strategies, European beech (*Fagus sylvatica*) and downy oak (*Quercus pubescens*), subjected to a five-year manipulation of soil moisture and air temperature. We quantified acclimation responses in leaf temperature regulation, hydraulic safety margins (HSMs), thermal safety margins (TSMs), and leaf scorching. Under sustained warming with ample soil water, both species acclimated to maintain stable leaf temperatures and positive TSMs, indicating that thermal acclimation is possible without hydraulic stress. In contrast, chronic drought narrowed HSMs and weakened evaporative cooling, reducing thermoregulation capacity. When heat and drought co-occurred, stomatal closure triggered a hydraulic–thermal feedback, leading to loss of cooling, exceedance of thermal thresholds, PSII failure, and leaf scorching in drought-vulnerable beech. These results show that trees can acclimate to warming alone, but not to combined heat and drought, which drive cascading failures that limit forest resilience to future hot-droughts.https://cassyni-user-files-prod.s3.amazonaws.com/2kFPNoXh45bHLu7eky5mKU https://cassyni.com/events/5diuko9mmNaj9Ku6xXm6Po/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Ty6xAnyJswB38ZqWu5G6W2 https://cassyni.com/events/C49mMgZbUKnQy9bZpS9Vzu/abstract https://cassyni-user-files-prod.s3.amazonaws.com/H1GrHdjGQeayTkmWZn3UGE https://cassyni.com/events/WLCNJEXnWz8DxB75t61XuF/abstract https://cassyni-user-files-prod.s3.amazonaws.com/GAbNTbNkR4px5QyDH4aeJz https://cassyni.com/events/WLCNJEXnWz8DxB75t61XuF?videoPreview=1 Welcome to Breaking Barriers: Connecting Research, People and Actionnohttps://cassyni.com/events/WLCNJEXnWz8DxB75t61XuF?videoPreview=12026-07-29T08:00:00+00:00279.56In this opening welcome, Nicola Jones, Director of the Springer Nature SDG Programme, introduces the mission behind Breaking Barriers and the vital role of interdisciplinary collaboration in advancing gender equality. Drawing on the Sustainable Development Goals (SDGs), Nicola highlights how connecting researchers, policymakers and practitioners can turn knowledge into meaningful action.https://cassyni-user-files-prod.s3.amazonaws.com/GAbNTbNkR4px5QyDH4aeJz https://cassyni.com/slides/outline/BwiZuMpcyTJPPdtwq1Ekm https://cassyni.com/events/BwiZuMpcyTJPPdtwq1Ekm/abstract https://cassyni-user-files-prod.s3.amazonaws.com/SgoCnaiEzVqXbBB3kaeRPC https://cassyni.com/events/BwiZuMpcyTJPPdtwq1Ekm?videoPreview=1 Building Data Culture, Governance, and AI Readiness: Bridging Clinical, Education, and Researchnohttps://cassyni.com/events/BwiZuMpcyTJPPdtwq1Ekm?videoPreview=12026-08-17T17:00:00+00:003708.84AAMCThis webinar brings together three Johns Hopkins efforts that show how a large academic medical center is approaching data governance, data culture, and responsible AI use. The value is not in presenting a finished model. It is in showing real institutional work in progress: strong efforts in separate domains, early connections across missions, and practical lessons for others facing the same complexity.https://cassyni-user-files-prod.s3.amazonaws.com/SgoCnaiEzVqXbBB3kaeRPC https://cassyni.com/events/LThsKGMMaxoFaUN3GLbMGh/abstract https://cassyni-user-files-prod.s3.amazonaws.com/GQvAywCWdo6zuucmXqAuan https://cassyni.com/events/LThsKGMMaxoFaUN3GLbMGh?videoPreview=1 Gender Equity Cannot Wait: Rights, Justice and Action for Women and Girlsnohttps://cassyni.com/events/LThsKGMMaxoFaUN3GLbMGh?videoPreview=12026-08-25T08:00:00+00:00155.36In this opening address, Magdalena Skipper, Editor-in-Chief of Nature and Chief Editorial Advisor for Nature Portfolio, reflects on the urgent need to advance gender equity in the face of persistent global inequalities. Drawing on the theme of the 2026 International Women's Day, Rights, Justice and Action for All Women and Girls, she highlights the challenges facing women and girls around the world and the critical role that research and scholarship play in informing policy, protecting rights and driving meaningful change.https://cassyni-user-files-prod.s3.amazonaws.com/GQvAywCWdo6zuucmXqAuan https://cassyni.com/events/YJvu47hKHcyFNWmYM5RrEh/seminar/qa https://cassyni.com/slides/outline/YJvu47hKHcyFNWmYM5RrEh https://cassyni.com/events/YJvu47hKHcyFNWmYM5RrEh/abstract https://cassyni-user-files-prod.s3.amazonaws.com/SaPxTqdieUV2xM6BgDDShC https://cassyni.com/events/YJvu47hKHcyFNWmYM5RrEh?videoPreview=1 Hybrid AI to enhance science, engineering and technologynohttps://cassyni.com/events/YJvu47hKHcyFNWmYM5RrEh?videoPreview=12026-01-07T16:00:00+00:003736.08Data-Centric Engineering JournalThis presentation revisits the genealogy, anatomy and physiology of digital twins, emphasizing the needs for advanced numerical technologies empowering the efficient solution of state-of-the-art physics-based models, while making use of recent data-driven technologies for bridging the gap with the physical reality. Model order reduction, machine learning, data-assimilation and immersive reality technologies will be integrated into the timely concept of digital twin, enabling for diagnosis prognosis and decision making of engineering components and multi-component systems These Digital Twins are then employed in the design and operation of materials, processes structures and complex systems of systems, enabling real-time predictions, optimization, uncertainty propagation, optimization and control, all of them under the stringent real-time constraint. The different concepts and tools will be motivated, introduced and applied in different domain of engineering, from materials behavior to the digital twin of cities and territories. https://cassyni-user-files-prod.s3.amazonaws.com/SaPxTqdieUV2xM6BgDDShC https://cassyni.com/slides/outline/E2gwKA7vRS9MMqoNKcPPgq https://cassyni.com/events/E2gwKA7vRS9MMqoNKcPPgq/abstract https://cassyni.com/events/E2gwKA7vRS9MMqoNKcPPgq?videoPreview=1 Optimal prevention strategies and reinsurance contract in a Stackelberg gamenohttps://cassyni.com/events/E2gwKA7vRS9MMqoNKcPPgq?videoPreview=12026-05-04T01:00:00+00:001345.36Risk SciencesAbstract: Dr. Jingchao Li 's research interests mainly lie in Actuarial, Risk Theory, Climate and Disaster Risk, InsurTech. This speech record is an excerpt from Dr. Li's keynote speech for the Risk Sciences Colloquium – [2025 International Workshop on Risk Sharing (IWRS)](https://www.keaipublishing.com/en/journals/risk-sciences/event/2025-international-workshop-on-risk-sharing-iwrs/) , which was held on July 6-7, 2025, in Beijing, China. [Risk sciences](https://www.keaipublishing.com/en/journals/risk-sciences/) aims to foster diverse, multidisciplinary insights in risk sciences, bridging theory and practice through a series of academic activities. https://cassyni.com/events/VLpHryh5RzEoVYfS6CwRdw/abstract https://cassyni-user-files-prod.s3.amazonaws.com/R2dpHF6aegGgUFYRiW2SP8 https://cassyni.com/events/NwFjocFjDDkgusQYjsomUZ/seminar/qa https://cassyni.com/slides/outline/NwFjocFjDDkgusQYjsomUZ https://cassyni.com/events/NwFjocFjDDkgusQYjsomUZ/abstract https://cassyni-user-files-prod.s3.amazonaws.com/8hP6WGtuoZKSexbVtqEMXU https://cassyni.com/events/NwFjocFjDDkgusQYjsomUZ?videoPreview=1 Introduction of the Lymphatic System and Invitation to Lymphatic Researchnohttps://cassyni.com/events/NwFjocFjDDkgusQYjsomUZ?videoPreview=12023-05-16T04:00:00+00:004406.76The Auckland Bioengineering InstituteThe lymphatic system has been the least investigated field in Medicine and Biology. The conventional topic of the lymphatic system has been cancer treatment because cancer cells tend to travel through the body via the lymphatic vessels. However, scientists gradually realise the critical need for further investigation because some medical conditions are believed to link to the dysfunction of the lymphatic system. I investigate the lymphatic system since 2001. First, I developed a new technique to visualise the lymphatic vessel in human and animal cadavers in 2005 and was awarded by the US plastic surgery research society in 2005. Currently, I operate an infrared imaging device for lymphoedema patients and provide a diagnostic imaging service at Macquarie University. In this talk, I would like to introduce the lymphatic system and the current and potential applications of bioengineering to this field. No special knowledge is required for my talk because most of my slides include visual materials. https://cassyni-user-files-prod.s3.amazonaws.com/8hP6WGtuoZKSexbVtqEMXU https://cassyni.com/events/3BKZxGNjeuc3CqQVikH3Ch/abstract https://cassyni-user-files-prod.s3.amazonaws.com/M3qnDjpnpMWMYf7F9SVYDU https://cassyni.com/events/YLAJ5pNK1VjDqeW7evzccD/seminar/qa https://cassyni.com/slides/outline/YLAJ5pNK1VjDqeW7evzccD https://cassyni.com/events/YLAJ5pNK1VjDqeW7evzccD/abstract https://cassyni-user-files-prod.s3.amazonaws.com/VWZV4jEFzn34WKxr9TAjz6 https://cassyni.com/events/YLAJ5pNK1VjDqeW7evzccD?videoPreview=1 Recent lexical expansion and change in New Zealand Sign Languagenohttps://cassyni.com/events/YLAJ5pNK1VjDqeW7evzccD?videoPreview=12024-08-09T04:10:00+00:002973.24Linguistics and Applied Language StudiesIn the past few decades, New Zealand Sign Language (NZSL) has seen changes in status, wider contexts of use, and ongoing contact with other (spoken and signed) languages. As a result, the NZSL lexicon is expanding and changing in nature. Using our analysis of close to 1,000 NZSL neologisms documented in the past five years, we discuss which semantic domains are showing the strongest growth; the linguistic mechanisms used to create new signs; and differences between planned (curriculum-related) terminology and community-generated neologisms.https://cassyni-user-files-prod.s3.amazonaws.com/VWZV4jEFzn34WKxr9TAjz6 https://cassyni.com/slides/outline/4A4Km3N4UcBkGMk1ChVfMX https://cassyni.com/events/4A4Km3N4UcBkGMk1ChVfMX/abstract https://cassyni-user-files-prod.s3.amazonaws.com/8SBQFQ4t1ZDVQbdXiFwSxv https://cassyni.com/events/4A4Km3N4UcBkGMk1ChVfMX?videoPreview=1 Isolation #1nohttps://cassyni.com/events/4A4Km3N4UcBkGMk1ChVfMX?videoPreview=12020-03-31T12:00:00+00:00195.6Hong Kong Baptist UniversityNo abstracthttps://cassyni-user-files-prod.s3.amazonaws.com/8SBQFQ4t1ZDVQbdXiFwSxv https://cassyni.com/events/EXg1jPx5hDpAns39DoSZ33/abstract https://cassyni-user-files-prod.s3.amazonaws.com/4fYcz6UD19Jjo1F2NooYSi https://cassyni.com/events/EXg1jPx5hDpAns39DoSZ33?videoPreview=1 How Does God Know 2+2=4? Theistic Platonismnohttps://cassyni.com/events/EXg1jPx5hDpAns39DoSZ33?videoPreview=12021-12-08T12:00:00+00:002025.28Hong Kong Baptist UniversityAbstract not yet added.https://cassyni-user-files-prod.s3.amazonaws.com/4fYcz6UD19Jjo1F2NooYSi https://cassyni.com/slides/outline/F2Kcn5bc8gNDnda2pEjMJM https://cassyni.com/events/F2Kcn5bc8gNDnda2pEjMJM/abstract https://cassyni-user-files-prod.s3.amazonaws.com/AVWN8fmy94mtnCK3hREnKp https://cassyni.com/events/F2Kcn5bc8gNDnda2pEjMJM?videoPreview=1 Hong Kong Cantopop: Sonic Memories and Political Identitiesnohttps://cassyni.com/events/F2Kcn5bc8gNDnda2pEjMJM?videoPreview=12020-06-21T12:00:00+00:006838.08Hong Kong Baptist UniversityNo abstracthttps://cassyni-user-files-prod.s3.amazonaws.com/AVWN8fmy94mtnCK3hREnKp https://cassyni.com/events/GzVhFNTQr6h5gspPvquL2R/abstract https://cassyni-user-files-prod.s3.amazonaws.com/XFYoPdtiFkt2a5xJEVEVJn https://cassyni.com/events/GzVhFNTQr6h5gspPvquL2R?videoPreview=1 Creating Scatter Plot by Groups in R - Ep.49nohttps://cassyni.com/events/GzVhFNTQr6h5gspPvquL2R?videoPreview=12022-07-06T12:00:00+00:00192.88Hong Kong Baptist UniversityAbstract not yet added.https://cassyni-user-files-prod.s3.amazonaws.com/XFYoPdtiFkt2a5xJEVEVJn https://cassyni.com/events/KTjiUnh33PTa3pHxUXoxkM/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Wfe8VGemSzgZXwJXXuGXmQ https://cassyni.com/events/KTjiUnh33PTa3pHxUXoxkM?videoPreview=1 Why is There 'Something' Rather Than 'Nothing'?nohttps://cassyni.com/events/KTjiUnh33PTa3pHxUXoxkM?videoPreview=12024-05-29T12:00:00+00:00593.24Hong Kong Baptist UniversityHere’s the ultimate question: what if it were true that everything always and forever had been ‘nothing’? Imagine that not a single thing ever existed–not emptiness, not blankness, not even the existence of emptiness, or the meaning of blankness. If you can image that, now ask yourself: why is there anything at all?https://cassyni-user-files-prod.s3.amazonaws.com/Wfe8VGemSzgZXwJXXuGXmQ https://cassyni.com/slides/outline/5daoBeaLkZx6QdqFZrTZ1X https://cassyni.com/events/5daoBeaLkZx6QdqFZrTZ1X/abstract https://cassyni-user-files-prod.s3.amazonaws.com/KDBwRa2QxZ3Jpm6tWhxSWJ https://cassyni.com/events/5daoBeaLkZx6QdqFZrTZ1X?videoPreview=1 Multimodal Mappingnohttps://cassyni.com/events/5daoBeaLkZx6QdqFZrTZ1X?videoPreview=12024-08-27T12:00:00+00:001374.0Hong Kong Baptist UniversitySamuel Swope’s practice is most recognized for his research and development of flight and air as medium. Merging multiple media and engineering practices, he constructs and controls aesthetic systems that work with air and are often themselves airborne. Throughout his practice he experiments with issues on the non-human, human-machine interaction, and emerging technologies to explore our place within these complex hybrid systems. Swope’s work has been exhibited internationally at venues such as the Smithsonian National Museum of American History, Washington DC; de Sarthe Gallery, Hong Kong; Krupic Kersting Gallery, Cologne; and Chronus Art Center, Shanghai. Swope’s studio is based in Hong Kong where he is also an assistant professor of art and technology at The Hang Seng University of Hong Kong.https://cassyni-user-files-prod.s3.amazonaws.com/KDBwRa2QxZ3Jpm6tWhxSWJ https://cassyni.com/slides/outline/7cbZ5ptjYp4PJ43ZrMsctM https://cassyni.com/events/7cbZ5ptjYp4PJ43ZrMsctM/abstract https://cassyni-user-files-prod.s3.amazonaws.com/3MGhQo7JqN1z8aE23QQCgv https://cassyni.com/events/7cbZ5ptjYp4PJ43ZrMsctM?videoPreview=1 From corpus-based interpreting studies to interpreting data "mining": breaking the boundariesnohttps://cassyni.com/events/7cbZ5ptjYp4PJ43ZrMsctM?videoPreview=12021-04-21T12:00:00+00:004799.88Hong Kong Baptist UniversityThis seminar addresses the evolution from corpus-based interpreting studies toward interpreting data mining, emphasizing the expansion and enhancement of interpreting corpora to facilitate large-scale pattern discovery. Interpreting is defined as the spoken form of translation involving a one-time rendition, with data types including audio, video, transcriptions, and note-taking, all crucial for linguistic and multimodal analysis. The discussion highlights the historical development of interpreting as a discipline and the challenges inherent in constructing large, annotated corpora due to the complexity of spoken language transcription and multimodal features. The Chinese/English Political Interpreting Corpus (CEPIC) and the larger SEPI corpus exemplify advances in open-access, richly annotated datasets, with SEPI reaching 6.5 million word tokens, surpassing previous corpora sizes. These corpora incorporate metadata such as speaker and interpreter gender, interpreting modes, and temporal information, enabling diverse research applications including lexical analysis, political discourse studies, and learner progression tracking. Semi-automatic and manual transcription and annotation processes are employed to ensure data quality, particularly for languages like Cantonese where automatic tools remain insufficient. The seminar also explores the potential of data mining to visualize and communicate interpreting-related knowledge beyond the discipline, including historical trends in the perceived roles of interpreters and correlations with technological developments such as AI and simultaneous interpreting equipment. Future directions call for interdisciplinary collaboration to develop larger, multimodal corpora, improve automatic processing accuracy, and create computer-assisted interpreting tools, thereby broadening the impact and accessibility of interpreting data research.https://cassyni-user-files-prod.s3.amazonaws.com/3MGhQo7JqN1z8aE23QQCgv https://cassyni.com/slides/outline/9bByGZUqJeH9PmKoDKjZJu https://cassyni.com/events/9bByGZUqJeH9PmKoDKjZJu/abstract https://cassyni-user-files-prod.s3.amazonaws.com/T3eTGLQ9XnhnBdboTTXsxJ https://cassyni.com/events/9bByGZUqJeH9PmKoDKjZJu?videoPreview=1 Panel Discussion on the International Art Exchange CITYAnohttps://cassyni.com/events/9bByGZUqJeH9PmKoDKjZJu?videoPreview=12021-10-01T12:00:00+00:004258.48Hong Kong Baptist UniversityCITYA is an international art project that will occur every three years as a long-term exchange among cities through art institutions and organizations. CITYA (“City as a Medium”) was inspired by social theorist Henri Lefebvre’s concepts between the city and art. Conceived by Hong Kong Baptist University Professor Janet Fong four years ago, several curators—including one of our instructors, Jenny E. Balisle—began the CITYA discussion when movement was free and global. Since the COVID-19 pandemic, the concept has transformed into how humanity resides within a “city” for the majority of time.https://cassyni-user-files-prod.s3.amazonaws.com/T3eTGLQ9XnhnBdboTTXsxJ https://cassyni.com/slides/outline/MvyjiCvfEgE75yXjwKcKkZ https://cassyni.com/events/MvyjiCvfEgE75yXjwKcKkZ/abstract https://cassyni-user-files-prod.s3.amazonaws.com/NM4sF5JZg43sW9HxbWTb9g https://cassyni.com/events/MvyjiCvfEgE75yXjwKcKkZ?videoPreview=1 Queering China and the Sinophone: A Joint Book Launchnohttps://cassyni.com/events/MvyjiCvfEgE75yXjwKcKkZ?videoPreview=12020-06-16T12:00:00+00:009145.28Hong Kong Baptist UniversityQueer cultures in China and the Sinophone world have undergone rapid development in recent decades. What are they like? How do they relate to each other? How do they help us understand sexuality, identity, globalization, nationalism, racism, and COVID-19? This joint book launch event will launch two books recently published by Routledge: Keywords in Queer Sinophone Studies, coedited by Howard Chiang and Alvin K. Wong; and Queer China: Lesbian and Gay Literature and Visual Culture under Postsocialism, authored by Hongwei Bao. Some contributing authors will introduce their articles in the former book; Jamie J. Zhao will chair the event and discuss the latter book. Together, these authors will chart the fascinating terrain of queer Chinese and Sinophone studies; they will also ask urgent questions about the place of queer cultures and queer theory in the global pandemic.https://cassyni-user-files-prod.s3.amazonaws.com/NM4sF5JZg43sW9HxbWTb9g https://cassyni.com/slides/outline/QQDkwdAHRxzbSv1JV1WxUV https://cassyni.com/events/QQDkwdAHRxzbSv1JV1WxUV/abstract https://cassyni-user-files-prod.s3.amazonaws.com/FMzMWq7se6rQ83x5V9zJSi https://cassyni.com/events/QQDkwdAHRxzbSv1JV1WxUV?videoPreview=1 Between Myth and Exoticism: Paradise Birds in Early Modern Japannohttps://cassyni.com/events/QQDkwdAHRxzbSv1JV1WxUV?videoPreview=12023-05-26T12:00:00+00:002585.48Hong Kong Baptist UniversityThis study examines the cultural and symbolic significance of birds-of-paradise in early modern Japan, highlighting their complex position between myth and exoticism. Departing from modern biological classifications, the analysis situates paradise birds within the intellectual and artistic frameworks of the period, emphasizing their role as “contrast agents” that reveal the circulation of objects, knowledge, and cultural meanings across regional domains and trade routes, notably through Nagasaki. The birds appear in diverse media, including illustrated texts, elite art objects, pharmacological treatises, and poetic compositions, where they are often associated with wind and paradisiacal imagery drawn from Buddhist and Taoist traditions. Early representations include preserved skins—frequently legless specimens imported by Dutch traders—and later live birds displayed in temples and commercial venues, reflecting a shift in accessibility and reception. The birds’ depiction blends imported exotic motifs with indigenous poetic and religious symbolism, challenging straightforward scientific identification. Key textual sources, such as the Honchō shokkan and dictionary entries by Confucian scholars like Arai Hakuseki, demonstrate varying intellectual engagements with these birds, from allegorical Buddhist contexts to pharmacological classifications. The study underscores the non-linear, media-ecological circulation of paradise bird imagery and knowledge, shaped by social context and modes of transmission rather than progressive scientific accuracy. This approach offers new insights into early modern Japanese cultural encounters with exotic fauna and the hybridization of myth, art, and natural history.https://cassyni-user-files-prod.s3.amazonaws.com/FMzMWq7se6rQ83x5V9zJSi https://cassyni.com/slides/outline/XowpdssA1qJRwVXmStNgtV https://cassyni.com/events/XowpdssA1qJRwVXmStNgtV/abstract https://cassyni-user-files-prod.s3.amazonaws.com/3juysCgFtVYgvbL45uU9hx https://cassyni.com/events/XowpdssA1qJRwVXmStNgtV?videoPreview=1 T08 Natural Language Processingnohttps://cassyni.com/events/XowpdssA1qJRwVXmStNgtV?videoPreview=12023-08-07T12:00:00+00:00477.32Hong Kong Baptist UniversityThis analysis explores fundamental techniques for extracting useful information from unstructured text data using Natural Language Processing (NLP). The process begins with a corpus, exemplified by a dataset of 1010 news articles. Core NLP preprocessing steps are outlined, including tokenization to segment text, part-of-speech tagging for word types, and lemmatization and stemming to normalise words to their basic forms. A practical demonstration using the Orange data mining software details a pipeline that involves loading the corpus, visualising content with a corpus viewer and word clouds, and applying text preprocessing. Preprocessing encompasses converting text to lowercase, removing accents and URLs, applying regular expression-based tokenization, and filtering for stopwords and numbers. This significantly improved word cloud visualizations, revealing key thematic terms such as "COVID," "cases," "England," "UK," and "vaccine" within the news articles. Furthermore, the analysis applies sentiment analysis using tools such as Vader, which categorise text polarity as positive, neutral, or negative and extract a compound sentiment value. This integrated approach, combining preprocessing, visualization, and sentiment analysis, provides a robust initial framework for exploratory data analysis of textual information.https://cassyni-user-files-prod.s3.amazonaws.com/3juysCgFtVYgvbL45uU9hx https://cassyni.com/slides/outline/SNpB8MkPBoDMYdHXqyNtu3 https://cassyni.com/events/SNpB8MkPBoDMYdHXqyNtu3/abstract https://cassyni-user-files-prod.s3.amazonaws.com/3T9TR1KRR8YarDddMwFzoY https://cassyni.com/events/SNpB8MkPBoDMYdHXqyNtu3?videoPreview=1 Fostering Social and Entrepreneurial Innovation through Art and Technologynohttps://cassyni.com/events/SNpB8MkPBoDMYdHXqyNtu3?videoPreview=12024-03-08T12:00:00+00:005317.36Hong Kong Baptist UniversityIn this sharing session, the two General Education (GE) Teaching Award recipients from the Academy of Visual Arts shared their good practices of integrating technology into GE art subjects. Ms Janet Fong, the winner of the GE Teaching Award (Early Career) AY2023/24, showcased how she capitalises on virtual and digital teaching and learning (VTL/DTL) elements in her GE Capstone course, GCAP3215 Art and the Community, to create significant societal impacts through community art. Ms Anna Qin, the recipient of the GE Teaching Award (Early Career) – Honourable Mention, also shared how her GE Level 2 courses, GTCU2007 Creative Entrepreneurship and GTSU2057 Sustainable Design Thinking, nurture students’ entrepreneurial creativity through technology. As an active member of the “GE Peer Support ‘Buddy’ Programme”, she discussed the benefits of collegial support to enhance teaching efficiency.https://cassyni-user-files-prod.s3.amazonaws.com/3T9TR1KRR8YarDddMwFzoY https://cassyni.com/slides/outline/SsTnB3PudFmQYPpRSQfhAM https://cassyni.com/events/SsTnB3PudFmQYPpRSQfhAM/abstract https://cassyni-user-files-prod.s3.amazonaws.com/52unL1SLWYt2FJ56TKcAri https://cassyni.com/events/SsTnB3PudFmQYPpRSQfhAM?videoPreview=1 Queering Applied Linguistics: Global Perspectives on Language Learningnohttps://cassyni.com/events/SsTnB3PudFmQYPpRSQfhAM?videoPreview=12022-10-07T12:00:00+00:002594.88Hong Kong Baptist UniversityThis seminar advances a queer applied linguistics framework to critically examine language learning, gender, and sexuality within global and local contexts. Grounded in critical applied linguistics, the approach interrogates how power relations and normative assumptions around gender and sexuality shape language learning processes, learner identities, and access to linguistic resources. Drawing on queer theory and queer linguistics, the analysis foregrounds temporality, spatiality, and normativity as intersecting dimensions that influence discriminatory language practices and socialization trajectories. A case study from Cambodia illustrates these concepts through ethnographic interview data with a local man engaged in transnational same-sex “sponsorship” relationships within queer ethnosexual contact zones of a tourist city. This study queers the second language socialization paradigm by emphasizing learning as emergent across multiple timescales and spaces beyond institutional settings, highlighting how sexual identities and multilingual competencies are co-constructed in socio-historical and political contexts. The participant’s narratives reveal dynamic processes of socialization that challenge heteronormative frameworks and underscore the complex entanglement of language, sexuality, and global-local power dynamics. The seminar concludes by advocating for ongoing critical reflexivity and openness to epistemic shifts in applied linguistics, encouraging research that moves beyond traditional classroom settings to engage diverse social arenas and mediates between academic and vernacular understandings of gender and sexuality. This work contributes to expanding applied linguistics through queer perspectives that problematize normative assumptions and enrich understandings of multilingual language practices in contemporary globalized contexts.https://cassyni-user-files-prod.s3.amazonaws.com/52unL1SLWYt2FJ56TKcAri https://cassyni.com/slides/outline/2B3Zrs3fgN5TNwXgvC5bUh https://cassyni.com/events/2B3Zrs3fgN5TNwXgvC5bUh/abstract https://cassyni-user-files-prod.s3.amazonaws.com/3bDLgj9SGkxTNTEsN3LtdL https://cassyni.com/events/2B3Zrs3fgN5TNwXgvC5bUh?videoPreview=1 Dorothy Tse and Quarantine with Natascha Bruce — TrChFic ep. 88nohttps://cassyni.com/events/2B3Zrs3fgN5TNwXgvC5bUh?videoPreview=12023-05-05T12:00:00+00:005659.88Hong Kong Baptist UniversityIn episode eighty eight of the Translated Chinese Fiction Podcast we are isolated in Hong Kong, experiencing Quarantine and all of the strange dreams that come with it. Are you me? Am I you? Do I wish I were you? Do you wish you were me, talking to Natascha Bruce, the razor-sharp translator of Dorothy Tse, about time, desire, and bottomless holes – is that your magic wish?https://cassyni-user-files-prod.s3.amazonaws.com/3bDLgj9SGkxTNTEsN3LtdL https://cassyni.com/events/RQh7qS6ZE31dhurhcMRKs3/abstract https://cassyni-user-files-prod.s3.amazonaws.com/AfyWh1V1ZPYCkfsjFo6Hx2 https://cassyni.com/slides/outline/H1kiPheHyLNnK6R4SwdCUu https://cassyni.com/events/H1kiPheHyLNnK6R4SwdCUu/abstract https://cassyni-user-files-prod.s3.amazonaws.com/QBfVebgBxW9FPNxjNPpcNS https://cassyni.com/events/H1kiPheHyLNnK6R4SwdCUu?videoPreview=1 Silence is bliss in a Platonic relationshipnohttps://cassyni.com/events/H1kiPheHyLNnK6R4SwdCUu?videoPreview=12021-07-20T14:00:00+00:004831.36MetaMATIn the context of active control we work in three dimensions and describe an effective cloaking strategy for the scalar Helmholtz equation. Building on the approach of Guevara-Vasquez et al, and Norris and Parnell, we employ multipole active sources. We choose to locate them at the vertices of the Platonic solids, thus creating a silent zone interior to the imaginary Platonic solid and ensuring that only the incident field remains exterior to the active source configuration. The Platonic distribution of the sources ensures an extremely efficient implementation of the cloaking strategy. In particular, once the multipole source amplitudes required at a single source location are determined, the other source amplitudes can be calculated by a simple post-processing involving multiplication of the source vector by a rotation matrix, exploiting the Platonic source distribution. Depending on time we may also briefly describe some recent work on elastic wave control via resonant metaclusters.https://cassyni-user-files-prod.s3.amazonaws.com/QBfVebgBxW9FPNxjNPpcNS https://cassyni.com/slides/outline/KUzjd7svAd9Gg2tczdXqCq https://cassyni.com/events/KUzjd7svAd9Gg2tczdXqCq/abstract https://cassyni-user-files-prod.s3.amazonaws.com/KUwoRWiyjSMjsi3h68tP9p https://cassyni.com/events/KUzjd7svAd9Gg2tczdXqCq?videoPreview=1 On the compact wave dynamics of tensegrity metamaterialsnohttps://cassyni.com/events/KUzjd7svAd9Gg2tczdXqCq?videoPreview=12021-03-02T14:00:00+00:007309.24MetaMATA research subject attracting remarkable attention from many areas of engineering concerns the use of noninvasive tools to target defects in materials, as well as devices for monitoring structural health in materials and structures. Most of current methods for the focusing and defocusing of acoustic waves (based mainly on exploiting linear acoustic effects) present the problem of having essentially little to no tunability ranges and poorly scalable dimensions. The use of highly nonlinear systems, allowing for a high level of control over the acoustic speed may enable the creation of revolutionary types of devices with far more advanced wave-focusing methodologies.This talk illustrates the employment of tensegrity metamaterials featuring elastically stiffening/hardening response for the fabrication of tunable focus acoustic lenses or innovative devices for monitoring structural health and damage detection in materials and structures. These devices support extremely compact compression waves in multiple dimensions. Previous research on 1D systems is generalized to 2D and 3D tensegrity beams and plates with stiffening-type response (acting as phononic crystals). The presented results reveal that the dynamics of such systems is characterized by the thermalization of the lattice nearby the impacted regions of the boundary. The portion of the absorbed energy moving along the longitudinal direction is transported by compression waves with compact support. Such waves emerge with nearly constant speed, and slight modifications of their spatial shape and amplitude, after collisions with compression waves traveling in opposite direction.https://cassyni-user-files-prod.s3.amazonaws.com/KUwoRWiyjSMjsi3h68tP9p https://cassyni.com/slides/outline/XqCqnD4394z8Zi8Rxz6ZLy https://cassyni.com/events/XqCqnD4394z8Zi8Rxz6ZLy/abstract https://cassyni-user-files-prod.s3.amazonaws.com/8mv1xr8vDoMDTz6fFi14bp https://cassyni.com/events/XqCqnD4394z8Zi8Rxz6ZLy?videoPreview=1 Multipurpose metamaterials: designing for static, acoustic and elastic properties in a single architecturenohttps://cassyni.com/events/XqCqnD4394z8Zi8Rxz6ZLy?videoPreview=12020-09-29T14:00:00+00:004230.12MetaMATMechanical metamaterials are materials with a tailored, architected structure, designed to achieve properties that depart from those found in natural or more “conventional” engineering materials. Common realizations of metamaterials are periodic and derive their properties from an interplay of the constitutive material responses and their architected geometry. Most of these designs to date have been developed to address a single functionality (e.g., for supporting a certain band gap, a low-frequency resonant response, a topological waveguide). However, many engineering applications have to satisfy simultaneously multiple constraints and demand specific static and dynamic responses. Increasing the design complexity allows the realization of materials with desirable effective properties, and added functionalities. In this talk, I will highlight some of our recent work in the design, fabrication and characterization of structured, multipurpose metamaterials and their possible application to engineering problems. For example, materials that can control acoustic and elastic waves simultaneously, which can function as ultimate protectors, or materials that are designed with specific acoustic impedance and load-bearing properties, which can function as acoustic windows, or flexible, resonant metamaterials for haptic interfaces.https://cassyni-user-files-prod.s3.amazonaws.com/8mv1xr8vDoMDTz6fFi14bp https://cassyni.com/slides/outline/5AAbAfbp2z9yDPSQHr4THo https://cassyni.com/events/5AAbAfbp2z9yDPSQHr4THo/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Cj6rLKK7jTnNFeZLepb7Ci https://cassyni.com/events/5AAbAfbp2z9yDPSQHr4THo?videoPreview=1 Nonuniformly elliptic problemsnohttps://cassyni.com/events/5AAbAfbp2z9yDPSQHr4THo?videoPreview=12021-03-18T15:00:00+00:003743.72Partial Differential Equations and ApplicationsRegularity for nonuniformly elliptic problems has been developed intensively over the last years, especially due to the interest raised by a few special model examples coming from the Calculus of Variations. I shall first give a brief overview of main results in the variational setting and then I shall present some more recent ones obtained in collaboration with Cristiana De Filippis (Università di Torino).https://cassyni-user-files-prod.s3.amazonaws.com/Cj6rLKK7jTnNFeZLepb7Ci https://cassyni.com/events/4fYcEcUAztXeN6buyyi6f7/abstract https://cassyni-user-files-prod.s3.amazonaws.com/MWJrvaKpMzH53ANmdPVjkz https://cassyni.com/slides/outline/PvoYveBkiPCUFfcTD17rkm https://cassyni.com/events/PvoYveBkiPCUFfcTD17rkm/abstract https://cassyni-user-files-prod.s3.amazonaws.com/KNGB8jCHrRqmhZNgv7fp2S https://cassyni.com/events/PvoYveBkiPCUFfcTD17rkm?videoPreview=1 How to deal with f-electrons in rare-earth nitrides: a critical review of existing approachesnohttps://cassyni.com/events/PvoYveBkiPCUFfcTD17rkm?videoPreview=12021-12-13T19:00:00+00:003683.16School of Chemical and Physical SciencesThe $f$-electrons in the lanthanides form an open shell with localized atomic-like orbitals. The traditional approach to study such systems uses atomic multiplet theory, crystal field theory and accounts well for the magnetic moments and shape of X-ray absorption and emission spectra.[1,2] However, it does not tell us anything about how these electrons affect the other electrons in the system, such as the lanthanide $d$-orbitals or the nitrogen $p$ orbitals in their nitrides. These are important to understand whether these materials are semiconductors or semimetals, to understand the hybridization effects of $f$-electrons with delocalized electrons in the system. The problem of how to reconcile band structure theory with the localized treatment of the $f$-electrons in a many-electron framework is not trivial. We review some of the existing approaches with a critical hindsight and discuss their successes and failures. One approach is to treat the open $f$-shell as core electrons [3,4] but which induce a spin-polarization on the other orbitals via the exchange effect. Relatedly, there are model approaches, in which the localized magnetic moments of the $f$-electrons are treated simply as localized spins with exchange interactions to the conduction electrons. [5] The self-interaction correction (SIC) approach is one attempt to make an orbital dependent Hamiltonian with the framework or density functional theory. [6] Another is the L(S)DA+U approach [7] in which the strong Coulomb interactions U and exchange interactions J of f-electrons are treated in a parametrized Hartree-Fock mean field treatment. But in this approach,[8-10] is the solution unique or does it depend on the initial choices of the density matrix for the f-electrons? Yet another approach is the quasi-particle self-consistent GW method, [11-15] which supposedly should describe the U and J effects via the self-energy and has no free parameters. Dynamic mean field theory using the Hubbard-I approximation[16-19] is perhaps the most sophisticated approach to bring together the atomic and band physics used so far. We will review these methods and illustrate some of their successes and shortcomings. https://cassyni-user-files-prod.s3.amazonaws.com/KNGB8jCHrRqmhZNgv7fp2S https://cassyni.com/slides/outline/5eqpKymDsodo2rRv5xBRU1 https://cassyni.com/events/5eqpKymDsodo2rRv5xBRU1/abstract https://cassyni-user-files-prod.s3.amazonaws.com/CeZvsk57KDkbSd4BHwpQ8N https://cassyni.com/events/5eqpKymDsodo2rRv5xBRU1?videoPreview=1 Polarisation Imaging of Soft Tissue Membranesnohttps://cassyni.com/events/5eqpKymDsodo2rRv5xBRU1?videoPreview=12021-11-09T03:00:00+00:002731.28The Auckland Bioengineering InstitutePolarisation imaging of biological media has a wide range of applications including cancer identification in tissues, such as colon, liver, cervix, breast, and skin; non-invasive glucose sensing; and non-destructive characterisation of the structural anisotropy in tissues containing fibrous components, such as collagen and actin-myosin. In this talk I will present my PhD work on the development of a wide-field Mueller matrix imaging system that has been integrated with a mechanical tester to enable structure-function studies of soft tissue membranes, such as pericardium, and discuss its potential applications in tissue engineering.https://cassyni-user-files-prod.s3.amazonaws.com/CeZvsk57KDkbSd4BHwpQ8N https://cassyni.com/events/Vre3i6ypnbhU2EePDQJtoF/seminar/qa https://cassyni.com/events/Vre3i6ypnbhU2EePDQJtoF/abstract https://cassyni-user-files-prod.s3.amazonaws.com/2RzFaFfgD5u1yrvFLsVTRg https://cassyni.com/slides/outline/QRUn5xMAZCgJ58by17Epvy https://cassyni.com/events/QRUn5xMAZCgJ58by17Epvy/abstract https://cassyni-user-files-prod.s3.amazonaws.com/GoWyh8x14ZmpFFbqwxxiTp https://cassyni.com/events/QRUn5xMAZCgJ58by17Epvy?videoPreview=1 From Kinematic to Energetic Control of Wearable Robots for Agile Human Locomotionnohttps://cassyni.com/events/QRUn5xMAZCgJ58by17Epvy?videoPreview=12022-03-23T16:00:00+00:002485.08Department of AeronauticsEven with the help of modern prosthetic and orthotic devices, individuals with lower-limb amputation, neurological disorders, or orthopedic disorders often struggle to walk in the home and community. Emerging powered prosthetic and orthotic devices could actively assist patients to enable greater mobility, but these devices are currently designed to produce a small set of pre-defined motions. Finite state machines are typically used to switch controllers between discrete phases of the gait cycle, e.g., heel contact vs. toe contact, and between different tasks, e.g., uphill vs. downhill. However, this discrete methodology cannot continuously synchronize the robot’s motion to the timing or activity of the human user. This talk will first present a continuous parameterization of human joint patterns based on 1) a phase variable that robustly represents the timing of the human gait cycle, and 2) task variables representing ground slope and walking speed. This parameterization is employed for user-synchronized control of a new powered knee-ankle prosthesis, which enables above-knee amputee subjects to walk at variable speeds/inclines with reduced compensations of intact joints. This approach will also be extended to continuously-varying impedance control to provide more normative joint energetics. While these methods reproduce missing joint function, a different control philosophy is needed for exoskeletons that assist existing joint function. The last part of this talk will introduce an energetic control paradigm for backdrivable exoskeletons to alter the human body’s dynamics without prescribing joint kinematics, e.g., reducing the perceived weight and inertia of the limbs. This control approach is implemented on exoskeletons with high-torque, low-impedance actuators, which provide the necessary backdrivability to facilitate volitional human control.https://cassyni-user-files-prod.s3.amazonaws.com/GoWyh8x14ZmpFFbqwxxiTp https://cassyni.com/slides/outline/NwZb4XvUeBwgXReoqxjxeZ https://cassyni.com/events/NwZb4XvUeBwgXReoqxjxeZ/abstract https://cassyni-user-files-prod.s3.amazonaws.com/7pX8Azzv9XFMpomFuWUwJe https://cassyni.com/events/NwZb4XvUeBwgXReoqxjxeZ?videoPreview=1 Electric propulsion research activities at ESAnohttps://cassyni.com/events/NwZb4XvUeBwgXReoqxjxeZ?videoPreview=12022-03-09T15:00:00+00:003444.12Department of AeronauticsELECTRIC PROPULSION AT THE EUROPEAN SPACE AGENCY The high specific impulse of Electric propulsion systems reduces the amount of propellant required to perform an operation in space. These savings will allow space projects to use smaller launches or increasing the payload. In the commercial arena (telecommunication and constellations space missions), the strong competition among satellite manufacturers is a major driver for advancements in the area of electric propulsion, where increasing better performance together with low prices are required. Furthermore, new scientific and Earth observation missions dictate new challenging requirements for propulsion systems and components based on advanced technologies such as microNewton thrusters. Moreover, new interplanetary missions in the frame of exploration will require sophisticated propulsion systems to reach planets such as Mercury or Mars and in some cases bring back to Earth samples from these planets. Space tugs, de-orbiting tugs and re-fuelling spacecraft will make also use of Electric Propulsion. Finally, Electric Propulsion systems will be used by the future EVO Galileo programme to perform orbit raising manoeuvres. Furthermore Cubesat electric propulsion systems will enable new missions. ESA is currently involved in activities related to spacecraft electric propulsion, from the basic research and development of conventional and new concepts to the manufacturing, Testing and flight control of the propulsion subsystems of several European satellites. The exploitation of the flight experience is also an important activity at ESA that will help mission designers to implement the lessons learnt to the development of these new propulsion systems. ESA missions such as Artemis, Smart-1, GOCE, Alphabus and Small-GEO, Bepi Colombo have paved the way for the use of electric propulsion in future ESA missions: Neosat, Electra, Mars Sample Return, LISA etc. https://cassyni-user-files-prod.s3.amazonaws.com/7pX8Azzv9XFMpomFuWUwJe https://cassyni.com/slides/outline/QvA1FGWaQ2ASd8w3Cvbu57 https://cassyni.com/events/QvA1FGWaQ2ASd8w3Cvbu57/abstract https://cassyni-user-files-prod.s3.amazonaws.com/DNJsjqfMnns9v4hFRCXVyY https://cassyni.com/events/QvA1FGWaQ2ASd8w3Cvbu57?videoPreview=1 The Commercial Conceptualization of Crytpocurrencynohttps://cassyni.com/events/QvA1FGWaQ2ASd8w3Cvbu57?videoPreview=12022-06-22T23:00:00+00:005566.12SACLIn the midst of a global meltdown of financially focused cryptocurrencies, distributed ledger technologies are in search of a second sentence. DLTs have always been combined techno-social systems. The commercial conceptualization of cryptocurrency -- the idea that the core application for blockchain is decentralized finance -- has kept academic focus overwhelmingly on the technological part of the policy problem. What the current meltdown reveals is the degree to which DLTs serve as loci for social and community organization. DLT communities organize around decentralized finance, but the level of commitment and community show that the payoff for investors is being involved in a movement or a cause. Similarly, NFTs are more than digital deeds. The deeds can designate unique online assets, but the real work of spinning up a blockchain is one of generating social value for those assets. Why a given Bored Ape has value is a far more important question than the operation of a distributed database technology. Much work remains yet to be done to adequately account for the social component of the policy question. This conversation will explore recent events in the current DLT meltdown with a view toward revealing and surfacing questions of community and identity that are increasingly coming to the forefront of distributed ledger tools and development. https://cassyni-user-files-prod.s3.amazonaws.com/DNJsjqfMnns9v4hFRCXVyY https://cassyni.com/events/TPQ2UgkCbJvvz5QbkcWXo3/seminar/qa https://cassyni.com/slides/outline/TPQ2UgkCbJvvz5QbkcWXo3 https://cassyni.com/events/TPQ2UgkCbJvvz5QbkcWXo3/abstract https://cassyni-user-files-prod.s3.amazonaws.com/VJXZFekr4tLeqMXuedoSCE https://cassyni.com/events/TPQ2UgkCbJvvz5QbkcWXo3?videoPreview=1 Talking about Optimal Transport - Luigi Ambrosio (SNS) interviewed by Alfio Quarteroni (PoliMI and EPFL)nohttps://cassyni.com/events/TPQ2UgkCbJvvz5QbkcWXo3?videoPreview=12022-06-09T12:30:00+00:003375.68Springer Nature WebinarsIn this session, which opens the series of webinars and talks related to the Springer UNITEXT Series, Alfio Quarteroni will interview Luigi Ambrosio about his experience as a student of the Scuola Normale - under the guidance of Ennio De Giorgi - as a researcher, as a teacher and as an author, having been lucky enough to be able to introduce many brilliant students to research. The speakers will also dive into the subject of Optimal Transport, and will discuss the most challenging open problems and the future developments in the field.https://cassyni-user-files-prod.s3.amazonaws.com/VJXZFekr4tLeqMXuedoSCE https://cassyni.com/events/RQqEQafzEqeGSbvZ12isFK/abstract https://cassyni-user-files-prod.s3.amazonaws.com/H57mcCEhG4avuL7SkTHPhx https://cassyni.com/events/RQqEQafzEqeGSbvZ12isFK?videoPreview=1 Being Pākehā: the politics of locationnohttps://cassyni.com/events/RQqEQafzEqeGSbvZ12isFK?videoPreview=12022-06-01T04:30:00+00:003558.44Stout Research Centre for New Zealand StudiesLydia Wevers' 'Being Pākehā: The Politics of Location' interrogates what it means to be Pākehā, engaging in a reflexive examination of culture and politics. The panel engages with this seminal article and explores persistent dis-ease about who Pākehā are. They extend this work beyond a focus on biculturalism to explore the place of tauiwi in a landscape shaped by the Christchurch mosque shootings, and within work by Māori towards tino rangitiratanga. In unpicking the politics and culture of this location, they continue the work of Lydia and many others to reassemble a place of radical justice.https://cassyni-user-files-prod.s3.amazonaws.com/H57mcCEhG4avuL7SkTHPhx https://cassyni.com/slides/outline/887Tg2WjUTL4DVN6qJvE6q https://cassyni.com/events/887Tg2WjUTL4DVN6qJvE6q/abstract https://cassyni-user-files-prod.s3.amazonaws.com/68mZXv3x9qfyaUF1g8LzbY https://cassyni.com/events/887Tg2WjUTL4DVN6qJvE6q?videoPreview=1 On the breaking inception of unsteady water wave packets evolving in the presence of constant vorticitynohttps://cassyni.com/events/887Tg2WjUTL4DVN6qJvE6q?videoPreview=12022-04-12T10:40:00+00:001823.36Water WavesThe recent numerical study of Barthelemy et al. (J. Fluid Mech., vol. 841, 2018, pp. 463–488) investigated the local properties of two-dimensional (2-D) and three-dimensional (3-D) nonlinear unsteady gravity wave packets in deep and uniform intermediate depth water. Their study focused on the breaking inception transition zone separating maximum recurrence and marginal breaking, and reported that a suitably normalized energy flux localized at the steepest crest in the packet provides a robust breaking threshold parameter. Our present study uses the fully nonlinear boundary integral element method solver developed by Touboul & Kharif (Nat. Haz., vol. 84, issue 2, 2016, pp. 585–598) to investigate breaking inception of 2-D deep water nonlinear water wave packets propagating in the presence of a background current that varies linearly with depth. We seek to validate whether the proposed generic breaking inception threshold holds for the case of constant background vorticity. Results are presented for different packet bandwidths and background vorticity levels.https://cassyni-user-files-prod.s3.amazonaws.com/68mZXv3x9qfyaUF1g8LzbY https://cassyni.com/slides/outline/2gypAWPxeREypd7sEPvS7P https://cassyni.com/events/2gypAWPxeREypd7sEPvS7P/abstract https://cassyni-user-files-prod.s3.amazonaws.com/W6BkXm8pgf67qH3Q877mqY https://cassyni.com/events/2gypAWPxeREypd7sEPvS7P?videoPreview=1 Quantum magnonics: when magnon spintronics meets quantum information sciencenohttps://cassyni.com/events/2gypAWPxeREypd7sEPvS7P?videoPreview=12022-07-13T12:00:00+00:004662.08Physics ReportsSpintronics and quantum information science are two promising candidates for innovating information processing technologies. The combination of these two fields enables us to build solid-state platforms for studying quantum phenomena and for realizing multi-functional quantum tasks. For a long time, however, the intersection of these two fields was limited due to the distinct properties of the classical magnetization, that is manipulated in spintronics, and quantum bits, that are utilized in quantum information science. This situation has changed significantly over the last few years because of the remarkable progress in coding and processing information using magnons. On the other hand, significant advances in understanding the entanglement of quasi-particles and in designing high-quality qubits and photonic cavities for quantum information processing provide physical platforms to integrate magnons with quantum systems. From these endeavours, the highly interdisciplinary field of quantum magnonics emerges, which combines spintronics, quantum optics and quantum information science. Here, we give an overview of the recent developments concerning the quantum states of magnons and their hybridization with mature quantum platforms. First, we review the basic concepts of magnons and quantum entanglement and discuss the generation and manipulation of quantum states of magnons, such as single-magnon states, squeezed states and quantum many-body states including Bose-Einstein condensation and the resulting spin superfluidity. We discuss how magnonic systems can be integrated and entangled with quantum platforms including cavity photons, superconducting qubits, nitrogen-vacancy centers, and phonons for coherent information transfer and collaborative information processing. The implications of these hybrid quantum systems for non-Hermitian physics and parity-time symmetry are highlighted, together with applications in quantum memories and high-precision measurements. Finally, we present an outlook on some of the challenges and opportunities in quantum magnonics.https://cassyni-user-files-prod.s3.amazonaws.com/W6BkXm8pgf67qH3Q877mqY https://cassyni.com/slides/outline/A6hsrm6qEHYpKCeLCGnAXP https://cassyni.com/events/A6hsrm6qEHYpKCeLCGnAXP/abstract https://cassyni-user-files-prod.s3.amazonaws.com/YT5VVVcJunYDvVM7sT37YJ https://cassyni.com/events/A6hsrm6qEHYpKCeLCGnAXP?videoPreview=1 Calculi for Many-Valued Logicsnohttps://cassyni.com/events/A6hsrm6qEHYpKCeLCGnAXP?videoPreview=12021-11-17T11:40:00+00:003175.64Logica UniversalisWe present a number of equivalent calculi for many-valued logics and prove soundness and strong completeness theorems. The calculi are obtained from the truth tables of the logic under consideration in a straightforward manner and there is a natural duality among these calculi. We also prove the cut elimination theorems for the sequent-like systems.https://cassyni-user-files-prod.s3.amazonaws.com/YT5VVVcJunYDvVM7sT37YJ https://cassyni.com/slides/outline/3BdRDC3V5so2pPekpqDENh https://cassyni.com/events/3BdRDC3V5so2pPekpqDENh/abstract https://cassyni-user-files-prod.s3.amazonaws.com/87o2EvNcfhpGMrETZMTMLr https://cassyni.com/events/3BdRDC3V5so2pPekpqDENh?videoPreview=1 Using narrative inquiry to explore the use of tasks in a Japanese language beginner course at university, Teacher research for English language teacher professional development: a three-level analysis of narrativesnohttps://cassyni.com/events/3BdRDC3V5so2pPekpqDENh?videoPreview=12022-09-09T04:00:00+00:003069.68Linguistics and Applied Language StudiesIn this talk I report on an action research study into how a Japanese language teacher experienced the transition from structure-based instruction to teaching with tasks. The study was situated in a course for beginner learners of Japanese at a university in New Zealand. I, the teacher-researcher, collected data on the experience of planning and teaching with tasks each week over ten weeks of a 12-week course. Weekly data included the teacher’s reflective journals, student survey data collected after each class, focus group data, and audio recordings of task-based interactions in class. Data from these sources was synthesised and analysed as narratives and presented as retrospective weekly stories. The paper reports on data from weeks 3 and 4 and focuses on the ways in which the teacher and students made sense of the task feature of learners needing to rely mainly on their own linguistic and non-linguistic resources, a task feature that is often perceived most difficult to put into practice by language teachers. Findings show how the teacher underestimated the students’ resilience and willingness to ‘have a go’ at performing challenging communicative tasks and the insights and strategies the teacher developed through the research.https://cassyni-user-files-prod.s3.amazonaws.com/87o2EvNcfhpGMrETZMTMLr https://cassyni.com/slides/outline/LxznzRrGHif1yxAm6NxJ6q https://cassyni.com/events/LxznzRrGHif1yxAm6NxJ6q/abstract https://cassyni-user-files-prod.s3.amazonaws.com/DkSWQKW4NF1oiFnHJ5DYEJ https://cassyni.com/events/LxznzRrGHif1yxAm6NxJ6q?videoPreview=1 AI Effects (AIX) in Computer Graphics (CG)nohttps://cassyni.com/events/LxznzRrGHif1yxAm6NxJ6q?videoPreview=12022-08-10T03:00:00+00:002185.24Computer Graphics GroupArtificial intelligence (AI) is a powerful tool and has increased operational efficiency and improved user experience in many areas. Computer Graphics (CG) is a domain that empowers Virtual Reality, Augmented Reality, and Metaverse. Many AI methods have been studied to boost CG and have achieved startling effects. In this talk, I will show how we innovate and apply AI in the CG pipeline to enhance user experience and productivity. We will see how to enable intelligence in media manipulation, media creation, and media engagement.https://cassyni-user-files-prod.s3.amazonaws.com/DkSWQKW4NF1oiFnHJ5DYEJ https://cassyni.com/slides/outline/PSEpDr5tV1RWLteKe4rvpm https://cassyni.com/events/PSEpDr5tV1RWLteKe4rvpm/abstract https://cassyni-user-files-prod.s3.amazonaws.com/HWP6Vvk2Rc1foy2t9SVoE6 https://cassyni.com/events/PSEpDr5tV1RWLteKe4rvpm?videoPreview=1 Coproduct and Amalgamation of Deductive Systems by Means of Ordered Algebrasnohttps://cassyni.com/events/PSEpDr5tV1RWLteKe4rvpm?videoPreview=12022-06-08T13:00:00+00:006052.12Logica UniversalisWe propose various methods for combining or amalgamating propositional languages and deductive systems. We make heavy use of quantales and quantale modules in the wake of previous works by the present and other authors. We also describe quite extensively the relationships among the algebraic and order-theoretic constructions and the corresponding ones based on a purely logical approach.https://cassyni-user-files-prod.s3.amazonaws.com/HWP6Vvk2Rc1foy2t9SVoE6 https://cassyni.com/events/Kyhau4ZDQoYsKCLkzQUyHw/abstract https://cassyni-user-files-prod.s3.amazonaws.com/9re1s2g6bEfx1bwEbmmy8A https://cassyni.com/events/Kyhau4ZDQoYsKCLkzQUyHw?videoPreview=1 Forty Years of Symmetry and Tiling with Marjorienohttps://cassyni.com/events/Kyhau4ZDQoYsKCLkzQUyHw?videoPreview=12021-02-27T19:30:00+00:00720.04Mathematical IntelligencerAbstract not yet added.https://cassyni-user-files-prod.s3.amazonaws.com/9re1s2g6bEfx1bwEbmmy8A https://cassyni.com/events/WMKGsR9EdRBHqhdu1WRryT/seminar/qa https://cassyni.com/slides/outline/WMKGsR9EdRBHqhdu1WRryT https://cassyni.com/events/WMKGsR9EdRBHqhdu1WRryT/abstract https://cassyni-user-files-prod.s3.amazonaws.com/XSyAQeAWtfcLkmqjcEUVZ8 https://cassyni.com/events/WMKGsR9EdRBHqhdu1WRryT?videoPreview=1 Optimal Transport, Fields Medals and beyond - Alessio Figalli (ETHZ) interviewed by Luigi Ambrosio (SNS)nohttps://cassyni.com/events/WMKGsR9EdRBHqhdu1WRryT?videoPreview=12022-09-07T13:00:00+00:002833.2Springer Nature WebinarsFigalli completed his Ph.D in studies in just one year, under the joint supervision of Luigi Ambrosio and Cèdric Villani. In 2018 he was awarded the Fields medal thanks to his contributions to Optimal Transportation. The speakers will talk about their common field of interests, their research, and the most challenging open problems in this area.https://cassyni-user-files-prod.s3.amazonaws.com/XSyAQeAWtfcLkmqjcEUVZ8 https://cassyni.com/slides/outline/8cngqLg9KGot2xMcdR3CH3 https://cassyni.com/events/8cngqLg9KGot2xMcdR3CH3/abstract https://cassyni-user-files-prod.s3.amazonaws.com/FJXPK2cYFNq3sL1DCgjDYA https://cassyni.com/events/8cngqLg9KGot2xMcdR3CH3?videoPreview=1 UCNS3D: An open-source high-order finite-volume unstructured CFD solvernohttps://cassyni.com/events/8cngqLg9KGot2xMcdR3CH3?videoPreview=12022-10-18T15:00:00+00:003175.48Computer Physics CommunicationsUCNS3D is an open-source computational solver for compressible flows on unstructured meshes. State-of-the-art high-order methods and their associated benefits can now be implemented for industrial-scale CFD problems due to the flexibility and highly-automated generation offered by unstructured meshes. We present the governing equations of the physical models employed in UCNS3D, and the numerical framework developed for their solution. We will be presenting the code design, philosophy and motivation for the high-order finite-volume framework, the performance of them under several challenging applications as well as the future developments of the UCNS3D.https://cassyni-user-files-prod.s3.amazonaws.com/FJXPK2cYFNq3sL1DCgjDYA https://cassyni.com/slides/outline/C5h1eJuLdAjP3qaQENeTYR https://cassyni.com/events/C5h1eJuLdAjP3qaQENeTYR/abstract https://cassyni-user-files-prod.s3.amazonaws.com/FHyDwHTouy7KxQqgGKUyB4 https://cassyni.com/events/C5h1eJuLdAjP3qaQENeTYR?videoPreview=1 Interacting Topological Quantum Aspects with Light and Geometrical Functionsnohttps://cassyni.com/events/C5h1eJuLdAjP3qaQENeTYR?videoPreview=12024-11-09T12:00:00+00:005017.92Physics ReportsI review my recent progress and develop a geometrical approach in the quantum with light as a guide, from the vector potential in classical physics, revealing that topological properties can be equivalently measured from the poles of a sphere. The topological state is induced on the Bloch sphere of a spin-1/2 particle from a radial magnetic field related to the physics of Skyrmions. This shows a relation between the global topological response being measured at the poles, the response to a circularly polarized field and the quantum metric. I show how this approach is helpful for the classification of matter with the detection of the global topological invariant at specific points in the Brillouin zone, e.g. the Dirac points, from the responses to electromagnetic waves such as circularly polarized light and from new geometrical functions associated to the quantum metric measuring the quantum Hall and spin Hall conductivities. The $M$ point associated to the Brillouin zone of the honeycomb lattice also reveals the topological signature. Interactions are included in momentum space within a stochastic variational approach. In a realistic quantum model of interacting spins, this leads to fractional topological entangled aspects with a correspondence between a pair of half invariants and a Einstein-Podolsky-Rosen (EPR) pair or Bell state at one pole. I also formulate a correspondence between fractional topological numbers and resonating valence bond states. This approach gives further insight on the characterization of topological matter linked to superconductivity, protected topological semimetals in two dimensions and on the search of Majorana fermions for topologically protected quantum information. We also address a correspondence with the fractional quantum Hall effect and surface states of three-dimensional topological insulators.https://cassyni-user-files-prod.s3.amazonaws.com/FHyDwHTouy7KxQqgGKUyB4 https://cassyni.com/slides/outline/QvaLxiEsSS4LpJP4VSgXYR https://cassyni.com/events/QvaLxiEsSS4LpJP4VSgXYR/abstract https://cassyni-user-files-prod.s3.amazonaws.com/4i17Q1DbS92MsJFvLTQtEi https://cassyni.com/events/QvaLxiEsSS4LpJP4VSgXYR?videoPreview=1 Hidden population turnover of small odontocetes in the northwestern North Pacific during the Holocenenohttps://cassyni.com/events/QvaLxiEsSS4LpJP4VSgXYR?videoPreview=12025-01-10T10:00:00+00:00704.4Royal Society PublishingDespite numerous studies on the rise and fall of terrestrial megafauna in the Late Quaternary, knowledge about marine megafauna from this period remains limited. Here, we performed radiocarbon dating and partial mitochondrial DNA sequencing from the skeletal remains of three species of small odontocetes (Pacific white-sided dolphins, Dall’s porpoises, and harbour porpoises) excavated from prehistoric archaeological sites around the Japanese shore dating back to 8500 – 1000 years ago. Pacific white-sided dolphins that habituated the eastern coast of Hokkaido (a.k.a. ‘Aynu Mosir’) around 2000 years ago belonged to different maternal groups than those from over 5000 years ago and today. Furthermore, the species composition excavated from eastern Hokkaido sites varies between 5000 and 2000 years ago. These findings suggest two significant population turnovers of small odontocetes on the east coast of Hokkaido, a transitional zone between the coastal area of East Asia and the offshore North Pacific. Notably, the first turnover, occurring between 5000 and 2000 years ago, represents the oldest evidence of local population turnovers of marine megafauna during the Late Quaternary.https://cassyni-user-files-prod.s3.amazonaws.com/4i17Q1DbS92MsJFvLTQtEi https://cassyni.com/events/2hQ9sx8Fgq8t1nZtWv14ah/abstract https://cassyni-user-files-prod.s3.amazonaws.com/QNRXDUmvxGEmdSVxSe1RCJ https://cassyni.com/events/69y1KNApAPwHsBL5NFDC2R/abstract https://cassyni-user-files-prod.s3.amazonaws.com/LGcAG1qs9Xzt3ZhhGXXtGW https://cassyni.com/slides/outline/3C3kvdmn8Hgw1Z6n7MHrr1 https://cassyni.com/events/3C3kvdmn8Hgw1Z6n7MHrr1/abstract https://cassyni-user-files-prod.s3.amazonaws.com/VrpH5trJK3hhFR2uKN9gbY https://cassyni.com/events/3C3kvdmn8Hgw1Z6n7MHrr1?videoPreview=1 Motion of test particles around an Einstein-dilaton-Gauss-Bonnet black hole in a uniform magnetic fieldnohttps://cassyni.com/events/3C3kvdmn8Hgw1Z6n7MHrr1?videoPreview=12025-02-05T05:00:00+00:002166.36Annals of PhysicsIn this work, we study the motion of a magnetized particle orbiting a static and spherically symmetric black hole immersed in an external asymptotically uniform magnetic field in Einstein-dilaton-Gauss-Bonnet gravity. Similar to the Schwarzschild case, the magnetic interaction creates a region that allows circular stable orbits near the photonic sphere, however, we show that regions in which there are no allowed solutions for circular orbits appear before the marginal stability is reached for weak magnetic interaction, namely, new criteria mark the frontier of the region of stable circular orbits for EdGB black holes. The regions of allowed stable circular orbits were calculated for different values of the dilaton-Gauss-Bonnet coupling $p$ and magnetic coupling parameter $\beta$, concluding that the increase of $p$ reduces the regions of stable circular orbits. The calculations were carried out using numerical black hole solutions and were compared with an analytical approximation with an error below $5\%$ for $p<0.25$.https://cassyni-user-files-prod.s3.amazonaws.com/VrpH5trJK3hhFR2uKN9gbY https://cassyni.com/events/CaNEod4kTzDCsJZv2UmRid/abstract https://cassyni-user-files-prod.s3.amazonaws.com/XKUMpTzr4BovNUVpMPkJJA https://cassyni.com/slides/outline/A78DaCq8GhSiWN6MUnrnzh https://cassyni.com/events/A78DaCq8GhSiWN6MUnrnzh/abstract https://cassyni-user-files-prod.s3.amazonaws.com/A4StMCNmYZ1WXX3zvaDUaA https://cassyni.com/events/A78DaCq8GhSiWN6MUnrnzh?videoPreview=1 A Primer On Resources And Best Practice For Metabolomics Workflowsnohttps://cassyni.com/events/A78DaCq8GhSiWN6MUnrnzh?videoPreview=12023-01-19T03:00:00+00:008165.2UKRNThis workshop provides a short introduction on the wide range of tools available for metabolomics workflows, as well as some considerations on how to best design your studies and how to get the most out of your data to ensure reproducibility across laboratories.https://cassyni-user-files-prod.s3.amazonaws.com/A4StMCNmYZ1WXX3zvaDUaA https://cassyni.com/slides/outline/Kz7vcWHWTDSmWMnnGvZbmF https://cassyni.com/events/Kz7vcWHWTDSmWMnnGvZbmF/abstract https://cassyni-user-files-prod.s3.amazonaws.com/K89PeMwNeXcWYEc8P7U8A2 https://cassyni.com/events/Kz7vcWHWTDSmWMnnGvZbmF?videoPreview=1 Understanding Gastrointestinal Side Effects in Liver Cancer Treatment: Insights from TACEnohttps://cassyni.com/events/Kz7vcWHWTDSmWMnnGvZbmF?videoPreview=12025-02-10T09:00:00+00:002061.44Sage PublishingHepatocellular carcinoma (HCC) is one of the leading causes of cancer-related deaths worldwide, and transarterial chemoembolization (TACE) remains a cornerstone in its treatment. By combining localized chemotherapy with vascular embolization, TACE offers a targeted approach to managing liver tumors. Chemotherapy, and specifically anthracyclines, are known to induce gastrointestinal (GI) side effects, such as chemotherapy-induced mucositis. However, whether these side effects also occur in TACE, where chemotherapy is delivered locally with reduced systemic exposure, has not been thoroughly investigated. Additionally, TACE is frequently associated with post-embolization syndrome (PES), a group of symptoms that include fever, nausea, vomiting, and abdominal pain, which can overlap with GI toxicity. The aim of our study was to quantify GI side effects, including nausea, diarrhea, abdominal pain, and toxicity, and to evaluate how these side effects are reported in clinical studies. In this seminar, we will present the findings from this meta-analysis of 81 studies encompassing data from 9,495 patients to quantify the prevalence of GI complications associated with TACE. The analysis highlights the prevalence of key side effects, with nausea being the most frequently reported (32.5%), followed by abdominal pain (46.1%), diarrhea (23.5%), and GI toxicity (9.9%). Our results also reveal variations in side effect profiles between conventional TACE (cTACE) and drug-eluting bead TACE (DEB-TACE), as well as the influence of the specific chemotherapy agents used within the TACE-emulsion. This seminar will highlight the clinical implications of our findings, focusing on the importance of standardized reporting of gastrointestinal side effects and strategies to improve their management. We will also discuss the broader context of TACE-related complications, including post-embolization syndrome, and their impact on patient outcomes.https://cassyni-user-files-prod.s3.amazonaws.com/K89PeMwNeXcWYEc8P7U8A2 https://cassyni.com/slides/outline/WrPDdYX47HdF2dcotToHi5 https://cassyni.com/events/WrPDdYX47HdF2dcotToHi5/abstract https://cassyni-user-files-prod.s3.amazonaws.com/SiXc7HbTHhQN8ZZM6vxsRY https://cassyni.com/events/WrPDdYX47HdF2dcotToHi5?videoPreview=1 Knowledge, practices of emergency contraception use and associated factors among female undergraduate students in Northern Uganda: a cross-sectional studynohttps://cassyni.com/events/WrPDdYX47HdF2dcotToHi5?videoPreview=12025-02-11T07:00:00+00:00924.6Women's HealthBackground: Emergency contraception (EC) can prevent up to 95% of unplanned pregnancies if used correctly. Despite efforts to enhance its accessibility, cost and cultural stigmas persist as formidable barriers. Objective: This study assessed the knowledge and practices of emergency contraception use and determined the associated factors among the female Undergraduate students of Northern Uganda. Design This was a descriptive institutional based cross-sectional study conducted among the female undergraduate students of Lira University in Northern Uganda. Methods Data was collected from 328 female undergraduates who were surveyed using self-administered questionnaires after obtaining informed consent from them. Data was analyzed using Statistical Package for Social Sciences (SPSS) and presented as frequencies and percentages, binary and multiple logistic regressions were used to determine the association between the outcome variable and the independent variables. Results were presented as odds ratios with 95% confidence intervals, and associations were considered statistically significant at P ≤ 0.05. Results: The response proportion was 328/334 (98%). Majority of the participants were 18–23 years old (233/328; 71.0%), had a consistent sexual partner (221/328; 67.4%), and unmarried (206/328; 62.8%). Almost all the participants (315/328; 96%) had heard about EC, where; 150/328 (45.7%) learned about EC from health professionals and 135/328 (41.2%) learned about EC from family members and friends. The most well-known brand of EC was Postinor-2 (Levonorgestrel), as reported by 130/328(39.6%) participants. Of the study participants, 200/328 (61.0%) were knowledgeable about the correct timing of EC. Regarding practices of EC use; 214/328 (65.2%) used EC, of whom 122/214 (57.0%) acquired EC from the pharmacy, and most of the participants who had used EC used Postinor-2 (92/214; 43.0%). Of those who used EC; 175/214 (81.8%) used it to prevent unplanned pregnancy, and 182/214 (85.0%) participants used it with the correct timing. The factors that were associated with EC use were being a student who was studying at the faculty of health sciences (AOR: 4.27, CI: 1.61, 10.09, P≤ 0.003) and absence of a consistent current sexual partner (AOR: 8.63, CI: 4.49, 16.59, P ≤ 0.00). Conclusion: Participants showed good EC knowledge and usage, but gaps persist. Factors like being a student who was studying at the Faculty of Health Sciences, and lack of a consistent current sexual partner correlated with EC use. Consistent education efforts are needed to address knowledge gaps, focusing on diverse EC forms, reliable information, and affordability https://cassyni-user-files-prod.s3.amazonaws.com/SiXc7HbTHhQN8ZZM6vxsRY https://cassyni.com/slides/outline/Bb8GwWoUPnxR94cGfSPXcR https://cassyni.com/events/Bb8GwWoUPnxR94cGfSPXcR/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Y3A5ZGijfTZPckQN57ViDc https://cassyni.com/events/Bb8GwWoUPnxR94cGfSPXcR?videoPreview=1 From Drops to Data: Harnessing Community Science to Decode Aquatic Microbiomes Across the Globenohttps://cassyni.com/events/Bb8GwWoUPnxR94cGfSPXcR?videoPreview=12025-04-15T16:00:00+00:00731.88Microbiome Virtual International ForumPredicting elemental cycles and maintaining water quality under increasing anthropogenic influence requires knowledge of the spatial drivers of river microbiomes. However, understanding of the core microbial processes governing river biogeochemistry is hindered by a lack of genome-resolved functional insights and sampling across multiple rivers. Here we used a community science effort to accelerate the sampling, sequencing and genome-resolved analyses of river microbiomes to create the Genome Resolved Open Watersheds database (GROWdb). GROWdb profiles the identity, distribution, function and expression of microbial genomes across river surface waters covering 90% of United States watersheds. Specifically, GROWdb encompasses microbial lineages from 27 phyla, including novel members from 10 families and 128 genera, and defines the core river microbiome at the genome level. GROWdb analyses coupled to extensive geospatial information reveals local and regional drivers of microbial community structuring, while also presenting foundational hypotheses about ecosystem function. Building on the previously conceived River Continuum Concept, we layer on microbial functional trait expression, which suggests that the structure and function of river microbiomes is predictable. We make GROWdb available through various collaborative cyberinfrastructures, so that it can be widely accessed across disciplines for watershed predictive modelling and microbiome-based management practices.https://cassyni-user-files-prod.s3.amazonaws.com/Y3A5ZGijfTZPckQN57ViDc https://cassyni.com/events/AboSjWzY7WvYKq5sGtymAu/abstract https://cassyni-user-files-prod.s3.amazonaws.com/UpK3fpcKZFgWPK9wHzaPBC https://cassyni.com/events/XM4SnrgTx774r6cKgZvFtH/abstract https://cassyni-user-files-prod.s3.amazonaws.com/HtKHaoc4nNESfYBLfcS3Wn https://cassyni.com/events/Pvv3PAFJKpuNqGpDPSGJ45/abstract https://cassyni-user-files-prod.s3.amazonaws.com/AEsdaCv16Cs1jebF4jdu42 https://cassyni.com/events/9c7X3LV5bYr8FePxNvyTjb/abstract https://cassyni-user-files-prod.s3.amazonaws.com/5LKWnsg5cgGDfytUv1xfwL https://cassyni.com/slides/outline/Lx3d72L8bTAJyHpMgNAcpM https://cassyni.com/events/Lx3d72L8bTAJyHpMgNAcpM/abstract https://cassyni-user-files-prod.s3.amazonaws.com/WxpChZeNCWbyNxmEZJCsjC https://cassyni.com/events/Lx3d72L8bTAJyHpMgNAcpM?videoPreview=1 The Prototypic crAssphage is a linear phage-plasmidnohttps://cassyni.com/events/Lx3d72L8bTAJyHpMgNAcpM?videoPreview=12025-10-15T00:30:00+00:00341.48Microbiome Virtual International ForumThe prototypic crAssphage (Carjivirus communis) is an abundant, prevalent, and persistent human gut bacteriophage, yet it remains uncultured and its lifestyle uncharacterized. C. communis does not readily plaque, suggesting a largely non-lytic lifestyle. Here, we find that C. communis is a linear phage-plasmid that stably persists extrachromosomally within its host. Plasmid and phage-related genes are transcribed, and multiple putative replication origins may initiate replication for multiple lifestyles and genome conformations, including both circular and linear formations. Leveraging these findings, we use a plaque-free culturing approach to measure C. communis replication on prevalent gut bacteria, notably Phocaeicola vulgatus, P. dorei, and Bacteroides stercoris, revealing a broad host range. C. communis persists without causing major cell lysis events or integrating into host chromosomes. Taken together, C. communis’ ability to switch between phage and plasmid lifestyles within a wide range of hosts may contribute to its widespread presence in human gut microbiomes.https://cassyni-user-files-prod.s3.amazonaws.com/WxpChZeNCWbyNxmEZJCsjC https://cassyni.com/slides/outline/MSR11Qpo1JT9BCZcNPMPpZ https://cassyni.com/events/MSR11Qpo1JT9BCZcNPMPpZ/abstract https://cassyni-user-files-prod.s3.amazonaws.com/79b8p3VxNhouPwxVMd6VfC https://cassyni.com/events/MSR11Qpo1JT9BCZcNPMPpZ?videoPreview=1 Mining the Human Gut Microbiome for Host-Compatible Anticancer Agents: Implications for Natural Tumor Surveillance nohttps://cassyni.com/events/MSR11Qpo1JT9BCZcNPMPpZ?videoPreview=12026-03-24T14:00:00+00:00571.12Microbiome Virtual International Forum"Background The human microbiome secretes bioactive molecules that modulate host physiology. While commensal biosynthetic potential is established, the role of the microbiome-derived peptides in natural tumor suppression remains underexplored. Driven by the evolutionary host compatibility concept, we hypothesized that commensal peptidome harbors bioactive sequences that selectively suppress aberrant cell growth while maintaining tolerance toward healthy host epithelium. Methods We deployed a consensus-based workflow (several machine learning algorithms) to mine putative peptides sourced from the human gastrointestinal system in the AMPSphere database. Sequences were scored for physicochemical properties, predicted activity, and ease of synthesis. A 22-mer candidate was selected for synthesis and validation. Results The peptide exhibited cytotoxicity against human MCF-7 (IC50 ≈ 380 μg/ml) and murine 4T1 (IC50 ≈ 430 μg/ml) carcinoma lines, alongside antibacterial activity (E. coli, S. aureus). Crucially, unlike non-selective pore-formers, the peptide spared healthy human epithelial cells (MCF-10; IC50 ≫ 500 μg/ml, >85% viability) and caused no vascular irritation in the HET-CAM model. Implications & Future Directions This study validates high-throughput microbiome mining for therapeutic leads. Future research could focus on: • Genomic Validation: Investigate human metagenomic cohorts (e.g., TCGA, HMP) for the prevalence of the specific Biosynthetic Gene Clusters (BGCs). Correlating BGC abundance with natural tumor suppression or response to Immune Checkpoint Blockade (ICB) could establish clinical ecological relevance. • Immunogenic Cell Death (ICD) potential: Mechanistic studies can determine if peptide-mediated lysis induces ICD. Quantifying the release of Damage-Associated Molecular Patterns (DAMPs) and subsequent dendritic cell priming could clarify if these agents could act as immune-adjuvants rather than simple cytotoxins. • Causal Assessment in Gnotobiotic Models: To distinguish between direct cytotoxicity and host-immune modulation, in vivo efficacy should be evaluated using gnotobiotic mice monocolonized with peptide-producing strains versus isogenic peptide-deficient mutants. • Engineering of Live Biotherapeutics (LBPs): To circumvent pharmacokinetic instability, a synthetic biology approach could be used. Engineering commensals with inducible circuits for in situ peptide secretion would enable targeted, continuous delivery within the tumor microenvironment."https://cassyni-user-files-prod.s3.amazonaws.com/79b8p3VxNhouPwxVMd6VfC https://cassyni.com/slides/outline/G1ZaeBrtCsd1WsXgBH7FQZ https://cassyni.com/events/G1ZaeBrtCsd1WsXgBH7FQZ/abstract https://cassyni-user-files-prod.s3.amazonaws.com/83NwTcqPPym29xzvmqPSQv https://cassyni.com/events/G1ZaeBrtCsd1WsXgBH7FQZ?videoPreview=1 Do irrotational water waves remain irrotational in the limit of a vanishing viscosity?nohttps://cassyni.com/events/G1ZaeBrtCsd1WsXgBH7FQZ?videoPreview=12025-12-11T15:00:00+00:002207.04Royal Society PublishingTheoretical results on water waves are almost always obtained first assuming irrotationality of the flow in order to simplify the formulation. In this presentation, we will discuss the well-foundedness of this hypothesis via numerical simulations of the free-surface Navier-Stokes equations. We show that, in the presence of a non-flat bathymetry, either angular or smooth, a gravity wave of finite amplitude can shed vortex pairs from the bottom boundary layer into the bulk of the flow. As these eddies approach the free surface they modify the shape of the wave. It is found that this perturbation does not vanish as the Reynolds number is increased. The vanishing viscosity limit of water waves is therefore singular when no-slip boundary conditions are enforced on the bottom.https://cassyni-user-files-prod.s3.amazonaws.com/83NwTcqPPym29xzvmqPSQv https://cassyni.com/events/AaRw8fk7NqXw81HSaN7TR7/abstract https://cassyni-user-files-prod.s3.amazonaws.com/88XwrjNx65QwaFi545Sg86 https://cassyni.com/slides/outline/LTReAyCVZMXz7zysNVpGBf https://cassyni.com/events/LTReAyCVZMXz7zysNVpGBf/abstract https://cassyni-user-files-prod.s3.amazonaws.com/PzwKRy3HdAphNhXd4V82Hc https://cassyni.com/events/LTReAyCVZMXz7zysNVpGBf?videoPreview=1 Identification and Management of the Backup Donor: Recommendations from the WMDAnohttps://cassyni.com/events/LTReAyCVZMXz7zysNVpGBf?videoPreview=12026-01-16T16:00:00+00:00884.96Bone Marrow TransplantationTiming of allogeneic hematopoietic cell transplantation (HCT) is a crucial factor that can significantly impact transplant outcome with delay potentially leading to disease progression or patient condition deterioration. While availability of unrelated donors is a key performance indicator of the World Marrow Donor Association (WMDA), registries often struggle to meet benchmark thresholds established to ensure that patients have timely access to transplant. At workup (WU), if the donor is unable to proceed due to unanticipated personal or medical reasons, the impact to patient care can be catastrophic; the transplant centre (TC) must urgently identify another suitable candidate for donation whose requisite testing and preparation can significantly extend the timeline to transplant. In 2024, global organisations indicated that 16% of all WU were canceled due to donor-related reasons, although unavailability rates varied substantially between participating registries. Despite initial rebound post-pandemic, donor unavailability at WU has increased steadily since 2021, now exceeding that experienced at the height of the pandemic in 2020 where it peaked at 15.2%.2 These findings underscore the need for patient registries and TC to define backup donor (BUD) strategies to mitigate patient risk. However, differences in national practices have resulted in variability in the search strategies, policies, and procedures currently used by organisations to ensure that various donor and treatment options are available for patients to minimise the risk of delayed transplant if a primary donor becomes unavailable. Reciprocally, these inconsistencies, combined with insufficient TC communication, can cause confusion for donor registries and donor centers (DC), potentially resulting in misinformed donors, unnecessary WU and/or product collection, and increased resource burden. The WMDA believes it is imperative that both donor and patient registries define policies for the proactive identification and management of BUD to minimise patient risk and to increase transparency and safety for BUD. Management of BUD at WU is a complex issue in which patient access to timely transplant must be balanced with the impact on prospective donors, DC and collection centre (CC) resources, and potential costs incurred by TC and their respective registries. Lack of standardisation in practice, including the definition of a BUD, has prompted the WMDA to provide the following guidance toward BUD policy and introduce a common language for describing BUD activities and emerging practices in donor management. We encourage organisations to define their policy in observation of the recommendations set forward herein. https://cassyni-user-files-prod.s3.amazonaws.com/PzwKRy3HdAphNhXd4V82Hc https://cassyni.com/slides/outline/4eHb6HHHseqwjt1FTszECd https://cassyni.com/events/4eHb6HHHseqwjt1FTszECd/abstract https://cassyni-user-files-prod.s3.amazonaws.com/5gQBLFWwTPdXZKnMzP7TCA https://cassyni.com/events/4eHb6HHHseqwjt1FTszECd?videoPreview=1 Relational Autonomy: Rethinking Informed Consent in Healthcare from Cross-Cultural and Religious Perspectivesnohttps://cassyni.com/events/4eHb6HHHseqwjt1FTszECd?videoPreview=12022-01-26T12:00:00+00:008878.52Hong Kong Baptist UniversityThe traditional individualistic framework of informed consent in healthcare often proves insufficient, particularly in diverse cultural and religious contexts, frequently reducing the process to a legalistic formality rather than true patient engagement. This necessitates a shift towards understanding autonomy as fundamentally relational, acknowledging that individual identities and interests are embedded within complex social networks. Cross-cultural analyses reveal varied approaches to healthcare decision-making, including individualist models (e.g., Houston), familist models (e.g., Beijing), and mixed models (e.g., Hong Kong). From non-Western perspectives, Buddhist philosophy emphasizes interdependent origination, challenging the notion of an isolated self, while Confucian virtue ethics integrates individual rights with familial harmony and shared decision-making. Legal systems globally vary in their mechanisms for resolving disputes, thresholds for intervention (e.g., welfare vs. harm), and the degree to which family or community voices are privileged. Despite rich theoretical insights, operationalizing relational autonomy within clinical practice and legal frameworks presents significant challenges. The prevailing emphasis on individual patient autonomy can lead to a "tyranny of legal procedures," potentially crowding out culturally relevant values and fostering defensive medical practices. Therefore, fostering culturally sensitive communication, building trust, and utilizing alternative dispute resolution mechanisms (e.g., clinical ethics committees, social work interventions) are crucial for bridging the gap between legal requirements and the ethical imperative to accommodate diverse values, ultimately enhancing patient-centred care.https://cassyni-user-files-prod.s3.amazonaws.com/5gQBLFWwTPdXZKnMzP7TCA https://cassyni.com/slides/outline/NvJZvCjbWxFyuD49Ks26C5 https://cassyni.com/events/NvJZvCjbWxFyuD49Ks26C5/abstract https://cassyni-user-files-prod.s3.amazonaws.com/PtAkkk36Rs5DusnaPcHmnE https://cassyni.com/events/NvJZvCjbWxFyuD49Ks26C5?videoPreview=1 Evidence of emperor penguins' sensitivity to sea ice fluctuationsnohttps://cassyni.com/events/NvJZvCjbWxFyuD49Ks26C5?videoPreview=12026-02-15T21:00:00+00:001743.24Royal Society PublishingUsing satellite-derived abundance indices over 20 years, we investigated population change among the seven Ross Sea emperor penguin (_Aptenodytes forsteri_) colonies. We found a 90% probability that the Ross Sea metapopulation had lower springtime attendance between 2005 and 2024 (mean change = -23%; 95% CI: -46 to +20%) and identified two distinct phases of change: slightly increasing 2005 to 2019/2020, followed by a steep decline 2020-2024, resulting in a decrease of ~23,000 birds in five years, or approximately 32% of the regional population. Over the 20 years, the two southernmost colonies, Cape Crozier and Cape Colbeck, increased in size, yet Beaufort, Coulman, Roget, and Washington declined, resulting in a negative population trend especially evident from 2021. Asynchronous population change suggests metapopulation dynamics, with immigration from western colonies possibly driving increases at Colbeck and Crozier. Winter and spring sea ice concentration anomalies (5-y lag) and El Niño phases (1-y lag) statistically explained the most variance in our time series. Our results indicate emperor penguins may be sensitive to sea ice fluctuations, offering insight into how this species may have adapted throughout their history, and emphasising the need for timely re-evaluation of targeted conservation strategies in an era of sea ice change. https://cassyni-user-files-prod.s3.amazonaws.com/PtAkkk36Rs5DusnaPcHmnE https://cassyni.com/slides/outline/VqP2ZmnwfN1mQ23ihJb2Lm https://cassyni.com/events/VqP2ZmnwfN1mQ23ihJb2Lm/abstract https://cassyni-user-files-prod.s3.amazonaws.com/31mn9rcEraKaxYHDXiqC2A https://cassyni.com/events/VqP2ZmnwfN1mQ23ihJb2Lm?videoPreview=1 Dynamic Simulations of Strongly Coupled Spin Ensembles for Inferring Nature of Electronic Correlations from Nuclear Magnetic Resonancenohttps://cassyni.com/events/VqP2ZmnwfN1mQ23ihJb2Lm?videoPreview=12026-03-03T12:48:29+00:002169.04Computer Physics CommunicationsWe develop an efficient package for the simulation of nuclear magnetic resonance spin echo experiments to study the effects of strong electronic spin correlations on the dynamics of the nuclear spin ensemble. A mean-field model is used to study correlated electronic phases through their hyperfine interaction with nuclear spins. We explore the dynamics of the interacting nuclear ensemble and discuss the key behaviors of the system. In particular, we classify the types of temporal asymmetry that the interaction induces in the system as well as a pulse-dependent shift in the spectral domain. Us- ing these results, we discuss how careful measurement of the pulse-dependent shift can be used to extract information about the anisotropy of the electronic interaction and how these results represent a novel tool for the examination of exotic NMR signatures in strongly correlated materials. Finally, we re- view specific aspects of the simulation package developed for our exploration and give explicit examples where package can be used to infer range and anisotropy of electronic correlations. In particular, we discuss its structure, accuracy, and the technical merits of the various approximations used to model the nuclear spin ensemble.https://cassyni-user-files-prod.s3.amazonaws.com/31mn9rcEraKaxYHDXiqC2A https://cassyni.com/events/TrqrcJEciFeq12G5EHjoRf/abstract https://cassyni.com/events/EXNAUUHLGFdBBcNj5Z7h6D/abstract https://cassyni-user-files-prod.s3.amazonaws.com/u7uWkcAjt2dXnjzBvQ3TC https://cassyni.com/events/EXNAUUHLGFdBBcNj5Z7h6D?videoPreview=1 Diet as a Microbiome Modifier: Ecological Considerations for Its Use Alongside Cancer Immunotherapynohttps://cassyni.com/events/EXNAUUHLGFdBBcNj5Z7h6D?videoPreview=12026-09-15T13:30:00+00:00779.12Microbiome Virtual International ForumDiet is a measurable modulator of the gut microbiome, but its effects are context-dependent, individualized, and constrained by microbial ecology. Plant-forward diets and targeted substrates such as fibre and prebiotics can induce substantial shifts in specific taxa, yet cohort-wide effects on overall community composition are often modest compared with dominant inter-individual differences. Diversity is also an imperfect marker of benefit, particularly in cancer patients whose microbiomes may already be disrupted by disease, treatment, and antibiotics. This talk will discuss what diet can realistically achieve as a microbiome modifier, using an ecological perspective that distinguishes taxonomic change, community-level constraints, and microbial function. I will argue that the most clinically relevant effects of diet may lie less in broadly “remodelling” the microbiome and more in shaping microbial metabolism, including short-chain fatty acids, tryptophan-derived metabolites, bile acids, and other pathways that plausibly connect diet, the microbiome, and immune function. The presentation will highlight opportunities, misconceptions, and key evidence gaps for dietary strategies alongside cancer immunotherapy.https://cassyni-user-files-prod.s3.amazonaws.com/u7uWkcAjt2dXnjzBvQ3TC https://cassyni.com/events/4eRhfRritTUaUa56rZHmau/abstract https://cassyni-user-files-prod.s3.amazonaws.com/9J6EXt3mChGvn8WenFkvWa https://cassyni.com/events/GzdopX2qruKiRZtFKXCsQh/abstract https://cassyni-user-files-prod.s3.amazonaws.com/KBcgEJUvLxRhPr94BPiACN https://cassyni.com/slides/outline/2BBgS1d6hAi67dbYJsP8ry https://cassyni.com/events/2BBgS1d6hAi67dbYJsP8ry/abstract https://cassyni-user-files-prod.s3.amazonaws.com/E5htm9B4uuAbr5bcTasL1L https://cassyni.com/events/2BBgS1d6hAi67dbYJsP8ry?videoPreview=1 Cytokine release syndrome in solid tumours: Mechanism-based therapeutic strategies for prevention and managementnohttps://cassyni.com/events/2BBgS1d6hAi67dbYJsP8ry?videoPreview=12026-06-29T10:00:00+00:002110.04Sage PublishingCytokine release syndrome (CRS) represents a spectrum of immune hyperactivation initiated by rapid T-cell engagement and amplified through innate immune cells, particularly monocytes and macrophages, with downstream cytokine cascades driving endothelial dysfunction, capillary leak and organ impairment. CRS is a frequent, class-associated toxicity of T-cell-engaging immunotherapies and is being observed with increasing regularity as T-cell-redirecting therapies progress through clinical development in solid tumours. Although CRS is typically less severe in patients with solid tumours relative to those with haematological malignancies, phase II-III trials of these emerging agents consistently report grade 1-2 CRS in the majority of patients, highlighting the need for effective prevention and management strategies, while preserving anti-tumour activity of the primary therapy. Current grading and management algorithms have been largely extrapolated from experience with chimeric antigen receptor T-cell therapies and rely on step-up dosing, premedication, supportive care and escalation to interleukin (IL)-6/IL-6R blockade and corticosteroids. However, steroid-refractory or high-grade CRS, as well as overlapping syndromes underscore the limitations of this approach and the need for mechanism-based interventions targeting upstream mediators and signalling hubs. These include IL-1 blockade, Janus kinase-signal transducer and activator of transcription inhibition, granulocyte-macrophage colony-stimulating factor neutralisation, tumour necrosis factor-alpha inhibition and interferon gamma blockade. In this narrative review, we synthesise the mechanistic rationale and emerging clinical evidence underpinning CRS prevention and management in solid tumours, with a particular focus on T-cell engager (TCE) and other T-cell-redirecting therapies. We then outline key risk-mitigation strategies and discuss their potential implications for anti-tumour immunity. Finally, we highlight key knowledge gaps, particularly the paucity of prospective solid tumour-specific data, with current CRS prevention and management strategies therefore remaining largely extrapolated from haematological malignancies, alongside the need for biomarker-driven risk stratification, optimal sequencing and prophylactic strategies and the development of next-generation TCE designs.https://cassyni-user-files-prod.s3.amazonaws.com/E5htm9B4uuAbr5bcTasL1L https://cassyni.com/events/4AhePXDSjuVTfmRzUTxUhB/seminar/qa https://cassyni.com/slides/outline/4AhePXDSjuVTfmRzUTxUhB https://cassyni.com/events/4AhePXDSjuVTfmRzUTxUhB/abstract https://cassyni-user-files-prod.s3.amazonaws.com/3phRCvTytLyQaws8rAHpog https://cassyni.com/events/4AhePXDSjuVTfmRzUTxUhB?videoPreview=1 Extinction risk of reef corals, past and presentnohttps://cassyni.com/events/4AhePXDSjuVTfmRzUTxUhB?videoPreview=12024-03-07T10:00:00+00:001868.04Cambridge PrismsCoral reefs are under increasing pressure from direct human impacts and human-induced climate change. Reef corals are also thought to be at elevated extinction risk but estimates vary profoundly among studies. Works that use lost reef area as a proxy of coral population reduction tend to estimate high extinction risk, whereas approaches using estimates of coral population sizes advocate low extinction risk. The fossil record contributes to this discussion that (i) reef corals have low intrinsic extinction risk, (ii) the loss of reef area is a poor predictor of coral extinction rates, and (iii) reef coral extinction pulses were usually triggered by episodes of profound global warming. Taken together, the deep-time observations support that the current reef crisis is unlikely be develop into a coral mass extinction in the next century of so. In addition, the Red List categorization of reef coral conservation status does not align well with empirical extinctions of the near-time past.https://cassyni-user-files-prod.s3.amazonaws.com/3phRCvTytLyQaws8rAHpog https://cassyni.com/events/EYuQm6d5R6a9FzmiXf1KQZ/seminar/qa https://cassyni.com/slides/outline/EYuQm6d5R6a9FzmiXf1KQZ https://cassyni.com/events/EYuQm6d5R6a9FzmiXf1KQZ/abstract https://cassyni-user-files-prod.s3.amazonaws.com/XEtLxP2NLbpretgTytV8mU https://cassyni.com/events/EYuQm6d5R6a9FzmiXf1KQZ?videoPreview=1 Gut Microbiome Wellness Index 2 enhances health status prediction from gut microbiome taxonomic profilesnohttps://cassyni.com/events/EYuQm6d5R6a9FzmiXf1KQZ?videoPreview=12024-10-09T14:00:00+00:00676.0Microbiome Virtual International ForumRecent advancements in translational gut microbiome research have revealed its crucial role in shaping predictive healthcare applications. Herein, we introduce the Gut Microbiome Wellness Index 2 (GMWI2), an enhanced version of our original GMWI prototype, designed as a standardized disease-agnostic health status indicator based on gut microbiome taxonomic profiles. Our analysis involves pooling existing 8069 stool shotgun metagenomes from 54 published studies across a global demographic landscape (spanning 26 countries and six continents) to identify gut taxonomic signals linked to disease presence or absence. GMWI2 achieves a cross-validation balanced accuracy of 80% in distinguishing healthy (no disease) from non-healthy (diseased) individuals and surpasses 90% accuracy for samples with higher confidence (i.e., outside the “reject option”). This performance exceeds that of the original GMWI model and traditional species-level α-diversity indices, indicating a more robust gut microbiome signature for differentiating between healthy and non-healthy phenotypes across multiple diseases. When assessed through inter-study validation and external validation cohorts, GMWI2 maintains an average accuracy of nearly 75%. Furthermore, by reevaluating previously published datasets, GMWI2 offers new insights into the effects of diet, antibiotic exposure, and fecal microbiota transplantation on gut health. Available as an open-source command-line tool, GMWI2 represents a timely, pivotal resource for evaluating health using an individual’s unique gut microbial composition.https://cassyni-user-files-prod.s3.amazonaws.com/XEtLxP2NLbpretgTytV8mU