https://cassyni.com/slides/outline/2KF1ML2Lh5VNvPZyWQZVbB https://cassyni.com/events/2KF1ML2Lh5VNvPZyWQZVbB/abstract https://cassyni-user-files-prod.s3.amazonaws.com/NR6nmy4AASmY4xGVaaM8ZL https://cassyni.com/events/2KF1ML2Lh5VNvPZyWQZVbB?videoPreview=1 Band structure and Dirac points of real-space quantum optics in periodic medianohttps://cassyni.com/events/2KF1ML2Lh5VNvPZyWQZVbB?videoPreview=12023-11-07T14:00:00+00:003794.68MetaMATThe field of photonic crystals is almost exclusively based on a Maxwell model of light. To capture light-matter interactions, it natural to study such systems under a quantum-mechanical photon model instead. In the real-space parametrization, interacting photon-atom systems are governed by a system of nonlocal partial differential equations. In this talk, we study resonant phenomena of such systems. Using integral equations, we phrase the resonant problem as a nonlinear eigenvalue problem. In a setting of high-contrast atom inclusions, we obtain fully explicit characterizations of resonances, band structure, and Dirac cones. Additionally, we present a strikingly simple relation between the Green’s function of the nonlocal equation and that of the local (Helmholtz) equation. In particular, we generalize existing lattice-summation methods to the nonlocal case. Based on this, we are able to achieve efficient numerical calculations of band structures of interacting photon-atom systems.https://cassyni-user-files-prod.s3.amazonaws.com/NR6nmy4AASmY4xGVaaM8ZL https://cassyni.com/events/8jj7BUTwCkY6xBoEhXoDw3/abstract https://cassyni-user-files-prod.s3.amazonaws.com/4faXGvhUqN3m9tKYz2e4TQ https://cassyni.com/slides/outline/9ErJArsXVLqsqXgtWba2ww https://cassyni.com/events/9ErJArsXVLqsqXgtWba2ww/abstract https://cassyni-user-files-prod.s3.amazonaws.com/TKqdxkYfVZmQan7G6bsvdt https://cassyni.com/events/9ErJArsXVLqsqXgtWba2ww?videoPreview=1 Designing molecular models by machine learning and experimental datanohttps://cassyni.com/events/9ErJArsXVLqsqXgtWba2ww?videoPreview=12020-12-11T14:00:00+00:003281.88AI Institute in Dynamic SystemsThe last years have seen an immense increase in high-throughput and high-resolution technologies for experimental observation as well as high-performance techniques to simulate molecular systems at a microscopic level, resulting in vast and ever-increasing amounts of high-dimensional data. However, experiments provide only a partial view of macromolecular processes and are limited in their temporal and spatial resolution. On the other hand, atomistic simulations are still not able to sample the conformation space of large complexes, thus leaving significant gaps in our ability to study molecular processes at a biologically relevant scale. We present our efforts to bridge these gaps, by exploiting the available data and using state-of-the-art machine-learning methods to design optimal coarse models for complex macromolecular systems. We show that it is possible to define simplified molecular models to reproduce the essential information contained both in microscopic simulation and experimental measurements.https://cassyni-user-files-prod.s3.amazonaws.com/TKqdxkYfVZmQan7G6bsvdt https://cassyni.com/slides/outline/PZ37zqJFMgX6XS26KWKR6V https://cassyni.com/events/PZ37zqJFMgX6XS26KWKR6V/abstract https://cassyni-user-files-prod.s3.amazonaws.com/PFvK8c4G4ciEoEp7NRifhp https://cassyni.com/events/PZ37zqJFMgX6XS26KWKR6V?videoPreview=1 Lagrangian Coherent Structures (LCS) in unsteady fluids with Finite Time Lyapunov Exponents (FTLE)nohttps://cassyni.com/events/PZ37zqJFMgX6XS26KWKR6V?videoPreview=12022-02-11T12:00:00+00:002752.12Brunton LabFluid dynamics are often characterized by coherent structures that persist in time and mediate the behavior and transport of the fluid. Lagrangian coherent structures (LCS) are a particularly important class of coherent structures, as they are the time-varying analogues of stable and unstable manifolds from dynamical systems theory, and they represent material lines of attraction and repulsion in the fluid. LCS are often computed via the Finite Time Lyapunov Exponent (FTLE) field, which involves computing the stretching between neighboring passive particles that are advected (integrated) along the flow field.https://cassyni-user-files-prod.s3.amazonaws.com/PFvK8c4G4ciEoEp7NRifhp https://cassyni.com/events/AiBQo4Ubwn8EKD1cfpMcyK/seminar/qa https://cassyni.com/slides/outline/AiBQo4Ubwn8EKD1cfpMcyK https://cassyni.com/events/AiBQo4Ubwn8EKD1cfpMcyK/abstract https://cassyni-user-files-prod.s3.amazonaws.com/SstCgX45n8szCQojGmi27Q https://cassyni.com/events/AiBQo4Ubwn8EKD1cfpMcyK?videoPreview=1 Dragonfly: Flights of Exploration Across Saturn's Moon Titan, an Organic Ocean Worldnohttps://cassyni.com/events/AiBQo4Ubwn8EKD1cfpMcyK?videoPreview=12023-06-20T15:30:00+00:003575.64AIAA JournalSaturn's largest moon, Titan, is an ocean world with a dense atmosphere, abundant complex organic material on its icy surface, and a liquid-water ocean within its interior. The Cassini-Huygens mission revealed surprisingly Earth-like geological processes and opportunities for organic material to have mixed with liquid water on Titan's surface in the past. These attributes make Titan a singular destination to seek answers to fundamental astrobiological questions about the habitability of other worlds in our solar system and prebiotic chemical processes like those that led to the development of life here on Earth. In this talk, I will present an overview of Titan and the exploration planned with NASA's upcoming Dragonfly New Frontiers mission. Dragonfly is a rotorcraft lander designed to perform wide-ranging in situ investigation of the chemistry and habitability of this carbon-rich extraterrestrial environment. Taking advantage of Titan's dense atmosphere and low gravity, Dragonfly will fly from place to place, exploring diverse geological settings to sample and measure detailed compositions of surface materials and observe Titan's geology and meteorology. During its ~3.3-year mission, Dragonfly will make multidisciplinary science measurements at a few dozen landing sites to characterize Titan's habitability and determine how far organic chemistry has progressed in environments that have provided key ingredients for life.https://cassyni-user-files-prod.s3.amazonaws.com/SstCgX45n8szCQojGmi27Q https://cassyni.com/slides/outline/L6Vtg3maHUeTVjiXfqwTZf https://cassyni.com/events/L6Vtg3maHUeTVjiXfqwTZf/abstract https://cassyni-user-files-prod.s3.amazonaws.com/SDJjMNfTSsNAGBnGC5CScN https://cassyni.com/events/L6Vtg3maHUeTVjiXfqwTZf?videoPreview=1 Nonlinear Control: Hamilton Jacobi Bellman (HJB) and Dynamic Programmingnohttps://cassyni.com/events/L6Vtg3maHUeTVjiXfqwTZf?videoPreview=12022-01-28T12:00:00+00:001058.12Brunton LabThis video discusses optimal nonlinear control using the Hamilton Jacobi Bellman (HJB) equation, and how to solve this using dynamic programming.https://cassyni-user-files-prod.s3.amazonaws.com/SDJjMNfTSsNAGBnGC5CScN https://cassyni.com/slides/outline/WxmBh617wYpw21YZHPB9WV https://cassyni.com/events/WxmBh617wYpw21YZHPB9WV/abstract https://cassyni-user-files-prod.s3.amazonaws.com/HWsy59pMRyQeEPs1zAZNLn https://cassyni.com/events/WxmBh617wYpw21YZHPB9WV?videoPreview=1 Active matter in inhomogeneous environmentsnohttps://cassyni.com/events/WxmBh617wYpw21YZHPB9WV?videoPreview=12023-05-05T15:00:00+00:003619.6Journal of Fluid MechanicsActive matter is a term used to describe matter that is composed of a large number of self-propelled active ‘particles’ that individually convert stored or ambient energy into systematic motion. Examples include a flock of birds, a school of fish, or at smaller scales a suspension of bacteria or even the collective motion within a human cell. When viewed collectively, active matter is an out-of-equilibrium material. This talk focuses on active matter systems where the active particles are very small, for example bacteria or chemically active colloidal particles. The motion of small active particles in homogeneous Newtonian fluids has received considerable attention, with interest ranging from phoretic propulsion to biological locomotion, whereas studies on active bodies immersed in inhomogeneous fluids are comparatively scarce. In this talk I will show how the dynamics of active particles can be dramatically altered by the introduction of fluid inhomogeneity and discuss the effects of spatial variations of fluid density, viscosity, and other fluid complexity.https://cassyni-user-files-prod.s3.amazonaws.com/HWsy59pMRyQeEPs1zAZNLn https://cassyni.com/events/G9K4JabNmpDJi5FrGjMQxm/abstract https://cassyni-user-files-prod.s3.amazonaws.com/7NXeWqRNPSiGUMKDzV7qM8 https://cassyni.com/events/MaUKvjE31DERyxY3ZvXkYm/seminar/qa https://cassyni.com/slides/outline/MaUKvjE31DERyxY3ZvXkYm https://cassyni.com/events/MaUKvjE31DERyxY3ZvXkYm/abstract https://cassyni-user-files-prod.s3.amazonaws.com/CyryvTJdnZJKcPHcGvSopi https://cassyni.com/events/MaUKvjE31DERyxY3ZvXkYm?videoPreview=1 Extensive polyploid clonality was a successful strategy for seagrass to expand into a newly submerged environmentnohttps://cassyni.com/events/MaUKvjE31DERyxY3ZvXkYm?videoPreview=12023-04-26T08:00:00+00:002931.08Royal Society PublishingPolyploidy has the potential to allow organisms to outcompete their diploid progenitor(s) and occupy new environments. Shark Bay, Western Australia, is a World Heritage Area dominated by temperate seagrass meadows including Poseidon's ribbon weed, Posidonia australis. This seagrass is at the northern extent of its natural geographic range and experiences extremes in temperature and salinity. Our genomic and cytogenetic assessments of 10 meadows identified geographically restricted, diploid clones (2n = 20) in a single location, and a single widespread, high-heterozygosity, polyploid clone (2n = 40) in all other locations. The polyploid clone spanned at least 180 km, making it the largest known example of a clone in any environment on earth. Whole-genome duplication through polyploidy, combined with clonality, may have provided the mechanism for P. australis to expand into new habitats and adapt to new environments that became increasingly stressful for its diploid progenitor(s). The new polyploid clone probably formed in shallow waters after the inundation of Shark Bay less than 8500 years ago and subsequently expanded via vegetative growth into newly submerged habitats.https://cassyni-user-files-prod.s3.amazonaws.com/CyryvTJdnZJKcPHcGvSopi https://cassyni.com/slides/outline/BCq1qk88PEgHJyYWGFeREd https://cassyni.com/events/BCq1qk88PEgHJyYWGFeREd/abstract https://cassyni-user-files-prod.s3.amazonaws.com/8ct449ktnLSE1Gv54Y7Vg https://cassyni.com/events/BCq1qk88PEgHJyYWGFeREd?videoPreview=1 Soft mechanics and fracture properties of cartilage and cartilage-inspired soft network materialsnohttps://cassyni.com/events/BCq1qk88PEgHJyYWGFeREd?videoPreview=12022-08-04T09:00:00+00:004155.28Journal of Biological PhysicsArticular cartilage (AC) is a soft tissue that provides a smooth cushion and distributes the mechanical load in joints. As a material, AC is remarkable. It is only a few millimeters thick, can bear up to ten times our body weight over 100-200 million loading cycles despite minimal regenerative capacity, and still avoids fracturing. Such properties are desperately needed for tissue engineering, tissue repair, and even soft robotics applications. I will discuss the structural origins of and microscopic mechanisms leading to AC's exceptional mechanical properties using the framework of rigidity percolation theory and compare our predictions with experiments. Our results provide an understanding of the tissue depth-dependent mechanical properties and how tissue mechanics changes in response to changes in tissue composition during diseases such as osteoarthritis. By combining this framework with biopolymer double networks, we show how micro-structure, composition, and constitutive mechanical properties can be tuned to resist and blunt cracks in cartilage-like soft materials. The flexibility in resulting material properties and ease of implementation can be harnessed to fabricate artificial tissue constructs with tunable mechanics. I will conclude with a discussion of new results from structurally inhomogeneous soft network materials that provide insights towards achieving this future.https://cassyni-user-files-prod.s3.amazonaws.com/8ct449ktnLSE1Gv54Y7Vg https://cassyni.com/events/J7w6bwhMw1MnxGEUvG9o1w/seminar/qa https://cassyni.com/slides/outline/J7w6bwhMw1MnxGEUvG9o1w https://cassyni.com/events/J7w6bwhMw1MnxGEUvG9o1w/abstract https://cassyni-user-files-prod.s3.amazonaws.com/6doxDxqjLZea5NHeZutvCv https://cassyni.com/events/J7w6bwhMw1MnxGEUvG9o1w?videoPreview=1 Probability Logics for Reasoning About Quantum Observationsnohttps://cassyni.com/events/J7w6bwhMw1MnxGEUvG9o1w?videoPreview=12023-04-26T14:00:00+00:003387.04Logica UniversalisIn this paper, we present two families of probability logics (denoted QLP and QLPORT ) suitable for reasoning about quantum observations. Assume that a means “O = a”. The notion of measuring of an observable O can be expressed using formulas of the form ??a which intuitively means “if we measure O we obtain a”. In that way, instead of non-distributive structures (i.e., non-distributive lattices), it is possible to relay on classical logic extended with the corresponding modal laws for the modal logic B. We consider probability formulas of the form CSz1,?1;...;zm,?m??a related to an observable O and a possible world (vector) w: if a is an eigenvalue of O, w1, . . . , wm form a base of a closed subspace of the considered Hilbert space which corresponds to eigenvalue a, and if w is a linear combination of the basis vectors such that w = c1·w1+. . .+cm·wm for some ci ? C, then ?c1 - z1? = ?1, . . . , ?cm - zm? = ?m, and the probability of obtaining a while measuring O in the state w is equal to Sm i=1?ci?2. Formulas are interpreted in reflexive and symmetric Kripke models equipped with probability distributions over families of subsets of possible worlds that are orthocomplemented lattices, while for QLPORT also satisfy ortomodularity. We give infinitary axiomatizations, prove the corresponding soundness and strong completeness theorems, and also decidability for QLP-logics.https://cassyni-user-files-prod.s3.amazonaws.com/6doxDxqjLZea5NHeZutvCv https://cassyni.com/events/LbB7qMvz8J8HKCi3Tx4Rjs/seminar/qa https://cassyni.com/slides/outline/LbB7qMvz8J8HKCi3Tx4Rjs https://cassyni.com/events/LbB7qMvz8J8HKCi3Tx4Rjs/abstract https://cassyni-user-files-prod.s3.amazonaws.com/RvX98xDWRs4vTy25hpTbs4 https://cassyni.com/events/LbB7qMvz8J8HKCi3Tx4Rjs?videoPreview=1 Wireless electrochemistry for determination of chirality in samplesnohttps://cassyni.com/events/LbB7qMvz8J8HKCi3Tx4Rjs?videoPreview=12023-07-18T13:00:00+00:002727.44Electrochimica ActaThe concept of inherent chirality has gained considerable attention due to the possible synthesis of π-conjugated monomers that can be employed for preparing chiral electrode surfaces after electrooligomerization [1]. These materials have been used in enantiorecognition measurements involving chiral analytes, resulting in high selectivity based on diastereomeric interactions between the deposited enantiopure antipode and the probes dissolved in solution. In this context the high enantioselectivity of such chiral surfaces was used in combination with the mechanical and electrical properties of polypyrrole (Ppy) films to develop three new straightforward read-outs for the absolute on-off recognition of enantiomers of a chiral probe in solution; i) electromechanical deformation [2], ii) electrochemically induced light emission [3] and iii) self-induced enantioselective trajectories [4]. These new approaches convert chiral information present at the molecular level into macroscopic actuation, light emission or controlled trajectories. Furthermore, such systems allow correlating the output signal with the concentration of the enantiomers present in solution, even in the case of mixtures containing different ratios of the molecular antipodes.https://cassyni-user-files-prod.s3.amazonaws.com/RvX98xDWRs4vTy25hpTbs4 https://cassyni.com/events/XTSQrQAXnNJkqUY55VJ7gh/seminar/qa https://cassyni.com/slides/outline/XTSQrQAXnNJkqUY55VJ7gh https://cassyni.com/events/XTSQrQAXnNJkqUY55VJ7gh/abstract https://cassyni-user-files-prod.s3.amazonaws.com/QpS5C6vL49xKAjNU3uriJ https://cassyni.com/events/XTSQrQAXnNJkqUY55VJ7gh?videoPreview=1 The Robots Are Here: Implications of Generative AI for Computing Educationnohttps://cassyni.com/events/XTSQrQAXnNJkqUY55VJ7gh?videoPreview=12023-06-13T04:00:00+00:003749.16The Auckland Bioengineering InstituteRecent breakthroughs in deep learning have led to the emergence of large language models (LLMs) that exhibit extraordinary performance at generating novel human-like content, including text, images and source code. It appears certain that such models will have a profound effect on educational practice and the development of tools for supporting student learning. For example, in the computing classroom, novices learning to code can use free tools to automatically suggest solutions to programming exercises and assignments. However, current tools were not designed with novices in mind, and little is known about how novices will interact with them in practice. Collaborative pedagogical approaches also look set for disruption. This talk will briefly present a timeline of the rapidly changing landscape of AI tools, summarise findings from recent work exploring the impact of LLMs in computing education, and discuss challenges and opportunities ahead.https://cassyni-user-files-prod.s3.amazonaws.com/QpS5C6vL49xKAjNU3uriJ https://cassyni.com/events/6m2CYDpHqUcog2FLZGi213/seminar/qa https://cassyni.com/slides/outline/6m2CYDpHqUcog2FLZGi213 https://cassyni.com/events/6m2CYDpHqUcog2FLZGi213/abstract https://cassyni-user-files-prod.s3.amazonaws.com/LjD4zUV8de6BAoS5yT2WZ4 https://cassyni.com/events/6m2CYDpHqUcog2FLZGi213?videoPreview=1 Pre-/post-processing & performancenohttps://cassyni.com/events/6m2CYDpHqUcog2FLZGi213?videoPreview=12023-06-15T10:00:00+00:006251.44NEKTAR++High-order mesh generation tools typically adopt the bottom-up approach - first creating a valid linear mesh followed by high-order tools for mesh curving. This poses a significant challenge for the linear mesh generation when very complex geometries are considered. Alternatively, one can produce the linear mesh with a third-party/commercial mesh generator and curve it in-house. NekMesh did have such capability, limited to a projection of only the edge quadrature points on the CAD. Now we present a complete redesign of this pipeline, which does not only projects edge and face nodes to the CAD B-Rep, but also integrates all NekMesh high-order modules for surface and volume optimizations, boundary-layer splitting and untangling into the process. By implementing this new pipeline, we have achieved the unique capability to produce meshes that exhibit similar surface&volume quality to the ones produced with the bottom-up approach, but also with the flexibility, robustness and user-friendly graphical user interface (GUI) of the commercial mesh generator. To demonstrate the capabilities of our new pipeline and showcase the improved mesh quality, we will show various simple and automotive geometries. The second part of this talk focuses on a posteriori mesh adaptation for compressible flows, specifically highlighting current activities in NekMesh and Nektar++. Initially, we will provide a brief overview of the existing r & p adaptation techniques and the new isoparametric h-adaptation. Then, these will be combined in r-p, h-p and h-r-p adaptations, showing the advantages of applying all three adaptation techniques simultaneously. To exploit parallelism, many codes are being deployed on heterogeneous systems so to make use of GPUs. Those developing codes have two options, write for a specific hardware (CUDA, HIP, SYCL, etc) or utilize a middle layer, Kokkos that encapsulates different hardware. In this talk the lessons learned from working on two different codes that utilize Kokkos and how these lessons can help guide Nektar++ as it transitions to heterogeneous systems. The post-processing and visualization of flow fields present two significant analysis and visualization challenges. The first challenge is the handling of elemental continuity, which is often only C0 continuous (in continuous Galerkin methods) or piecewise discontinuous (in discontinuous Galerkin methods). The second challenge is that, depending on the flow regime and other considerations, the meshes generated are often highly anisotropic. The (uniform-knot) line-SIAC (L-SIAC) filter has been proposed as a way of handling elemental continuity issues in an accuracy-conserving manner with the added benefit of casting the data in a smooth context even if the representation is element discontinuous. In this talk, we demonstrate that the state-of-the-art adaptive L-SIAC filter, designed for anisotropic meshes, suffers degradation in the quality of the post-processed solution when applied to the types of highly anisotropic meshes produced through adaptive mesh refinement and optimization. Hence, a new Non-Uniform Knot (NUK) L-SIAC filter is proposed that automatically conforms to the underlying mesh anisotropy. We demonstrate that the new filter behaves similarly to the adaptive L-SIAC filter when applied to uniform and mildly anisotropic meshes, and furthermore we show the superiority of the NUK L-SIAC filter when applied to highly anisotropic meshes.https://cassyni-user-files-prod.s3.amazonaws.com/LjD4zUV8de6BAoS5yT2WZ4 https://cassyni.com/slides/outline/TzuBXcdriAS7onEWRpvA9s https://cassyni.com/events/TzuBXcdriAS7onEWRpvA9s/abstract https://cassyni-user-files-prod.s3.amazonaws.com/9crDSN6tUAP8zpUMmfV9k2 https://cassyni.com/events/TzuBXcdriAS7onEWRpvA9s?videoPreview=1 Enabling a circular biodegradable plastic flow through a systems-thinking frameworknohttps://cassyni.com/events/TzuBXcdriAS7onEWRpvA9s?videoPreview=12023-07-31T13:00:00+00:001000.84Imperial College London Early Career Researcher InstituteThe threat of climate change has accelerated the shift in production and consumption patterns towards more sustainable systems. The proposition of a circular bioeconomy has favoured the development of biodegradable plastics in fast-moving consumer goods, especially in food packaging applications. Since biodegradable plastics can be disposed and treated alongside organic waste, including municipal and commercial food waste, they can contribute towards closed-loop material and product flows. Consumers play a key role as enablers of these flows, provided they accept, understand, use and dispose of biodegradable plastics appropriately. Mapping and facilitating the role of consumer behaviour in tackling post-consumer biodegradable plastic waste is therefore pivotal in designing sustainable systems for these materials and for achieving a circular plastic economy. To date, literature on pro-environmental behaviour, including recycling, reuse and the adoption of biodegradable plastics has focused on understanding these actions as individual circular behaviours. Adopting a systems approach, we first mapped the consumer behaviour chain that unfolds across stages of acquisition, use and disposal of biodegradable plastics. Informed by a systematic literature review and focus groups, we then developed a stratified framework to identify and structure factors (system elements) that influencing how consumers interact with biodegradable plastics, ultimately enabling or hindering the progression of the behaviour chain. Overall, 18 system elements (further split in 35 system sub-elements) were identified across 6 broad structural categories consisting of resources, intrinsic drivers, data, value, infrastructure and policy. The emerging model acted as a foundation for the design of a survey, as a means of moving from qualitative to quantitative insights. We aimed to explore the dynamic interactions that occur within the system and investigate how system elements interact with each other and how they influence consumer behaviour, focusing on behavioural intentions for circular disposal (which, in the context of this study, was defined as the intention to of dispose biodegradable food packaging waste in food/organic waste bins) and disposal behaviour more broadly. The survey was conducted at two academic institutions, Imperial College London (United Kingdom) and the University in California, Davis (United States), and formed the basis of a comparative case study and network analysis, in which the role of contextual setting of each case study site on behavioural intentions was also investigated. Results suggested that the presence and consistency of the relevant waste management infrastructure, as well as knowledge of bioplastic terminology and of appropriate disposal routes, play a key role in enhancing circular disposal intentions (and, hypothetically, ultimate circular disposal). The University of California, Davis's unique contextual setting, characterised by comprehensive state and institutional policies on organic waste management, contributed towards a more developed and consistent organic waste management infrastructure (including for food and food packaging waste), which in turn led to a higher proportion of surveyed participants to state having access to a separate food waste collection scheme and to display circular disposal behavioural intentions. Our approach enabled us to identify leverage points most effectively across the consumption phase of biodegradable plastics to inform design strategies aimed at supporting consumers as they transition towards more pro-environmental behaviour in the context of plastics sustainability and integrated human-physical systems. Image credit: [Jilbert Ebrahimi (Unsplash)](https://unsplash.com/photos/b0p818k8Ok8).https://cassyni-user-files-prod.s3.amazonaws.com/9crDSN6tUAP8zpUMmfV9k2 https://cassyni.com/events/pYA5PM3Su5nGvXzYo12Gu/seminar/qa https://cassyni.com/slides/outline/pYA5PM3Su5nGvXzYo12Gu https://cassyni.com/events/pYA5PM3Su5nGvXzYo12Gu/abstract https://cassyni-user-files-prod.s3.amazonaws.com/ELjpVdJm4NEQkg4HhhgDDY https://cassyni.com/events/pYA5PM3Su5nGvXzYo12Gu?videoPreview=1 Session 2: Optimisationnohttps://cassyni.com/events/pYA5PM3Su5nGvXzYo12Gu?videoPreview=12023-10-05T10:00:00+00:005602.24Brahmal Vasudevan Institute for Sustainable Aviation at Imperial College London**Chair: Prof Laura Mainini, Imperial College**https://cassyni-user-files-prod.s3.amazonaws.com/ELjpVdJm4NEQkg4HhhgDDY https://cassyni.com/events/9EGDme3v2mPcmW4TWfrkgu/seminar/qa https://cassyni.com/slides/outline/9EGDme3v2mPcmW4TWfrkgu https://cassyni.com/events/9EGDme3v2mPcmW4TWfrkgu/abstract https://cassyni-user-files-prod.s3.amazonaws.com/3s7FwuwCFBSi8xoG22u5GS https://cassyni.com/events/9EGDme3v2mPcmW4TWfrkgu?videoPreview=1 Research writingnohttps://cassyni.com/events/9EGDme3v2mPcmW4TWfrkgu?videoPreview=12023-08-22T18:30:00+00:003701.0SCIWRITERJust as our body handles a quick sprint differently to an endurance event, so our brain has two ways of processing information. Daniel Kahneman's book, Thinking Fast and Slow, suggests that when we skim-read a text, we primarily engage our fast, instinctive brain that makes snap decisions based on prior knowledge and 'muscle memory'. This can be a benefit - if our prior knowledge is reliable - but can lead us astray, particularly if we are less experienced and lack the required background knowledge. Instead, when evaluating complex information, we need to be able to engage both our fast brain and our slow, methodical brain as well. Research among educators suggests that this can be done in the following ways: - Previewing the material by identifying key concepts. - Cross-referencing technical terms to supporting materials. - Signposting the overall structure and most important points. - Chunking the material and providing non-linear interaction, or organizing the material in a more visual way. At Scholarcy, we apply technology to allow any researcher or student to implement these strategies themselves in a personalised way. By converting any collection of source documents, in any format, into our interactive flashcards, we support both informed skim reading and deeper analysis, while saving time and energy. In this seminar, I'll show you how to get the most from our suite of tools, helping you to supercharge your research and hopefully to successful completion of your studies. Writing lies at the heart of success in academia, but language can be a barrier to publication. In Does Science Need a Global Language, Scott Montgomery notes that over 75% of scientific papers are in English, with this figure reaching 90% in some fields. The added burden of writing in English requires authors with English as a second language to put in more time and effort in writing a research paper for journal submission, only to face a higher risk of rejection. With professional editing being time-consuming and expensive, researchers need an academic writing assistant they can trust. Here, Paperpal has emerged as a game-changing AI tool for researchers, offering high-quality writing support at a fraction of the cost. With precise AI academic translation, contextual synonym suggestions, paraphrasing support, and a range of in-depth language, consistency, and technical checks, Paperpal can support you from the draft-writing stage to final journal submission. In this seminar, I'll discuss how this AI academic writing tool, trusted by researchers and journals alike, can help you beat the writer’s block and overcome language barriers, ensuring you achieve your publication goals faster Researchers around the world spend hours online every week navigating millions of links across multiple databases to find new, relevant research articles or publications. In fact, an Elsevier and Sense About Science report showed that apart from robbing researchers of valuable time, this time-consuming effort often counts for nothing as nearly half of the shortlisted articles are not useful! This is where R Discovery, an AI-powered literature discovery and research reading app, aims to help researchers quickly discover, manage, access, and read a wide range of reliable research content. From personalized reading suggestions based on your preferences to curated research feeds, reading lists by the researcher community to options for how you consume research, this top-rated app puts the world of research in the palm of your hand. In this seminar, I’ll delve into how you can make the most of R Discovery’s meticulously designed AI features to maximize your time and productivity and stay ahead of the curve! https://cassyni-user-files-prod.s3.amazonaws.com/3s7FwuwCFBSi8xoG22u5GS https://cassyni.com/slides/outline/K7FvowWJDHPfmoLjGeAtgd https://cassyni.com/events/K7FvowWJDHPfmoLjGeAtgd/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Czo6nHBGE8VQeHmgr2w2CW https://cassyni.com/events/K7FvowWJDHPfmoLjGeAtgd?videoPreview=1 Scholarly Communication at the Dawn of Exponential Revolutionnohttps://cassyni.com/events/K7FvowWJDHPfmoLjGeAtgd?videoPreview=12023-05-08T17:00:00+00:003679.92DeSci FoundationIt is clear that we are entering a new phase of technological growth: Not an industrial revolution of the type that we have seen before but an exponential revolution awaits with all the challenges and wonders that entails. An abundance of data coupled with sophisticated tools for both capturing and analysing data has transformed research over the last half century. And yet, scholarly communication is still reliant on 17th Century technology. In this seminar we examine why this is the case and what the future of scholarly communication could look like.https://cassyni-user-files-prod.s3.amazonaws.com/Czo6nHBGE8VQeHmgr2w2CW https://cassyni.com/slides/outline/VUscnJ6KRu26JJdsHk7nN9 https://cassyni.com/events/VUscnJ6KRu26JJdsHk7nN9/abstract https://cassyni-user-files-prod.s3.amazonaws.com/RDsRnpxPVa7ZBHv5UcmL7g https://cassyni.com/events/VUscnJ6KRu26JJdsHk7nN9?videoPreview=1 Repulsion and rotation: Penetrating granular matter near a wallnohttps://cassyni.com/events/VUscnJ6KRu26JJdsHk7nN9?videoPreview=12020-08-28T12:00:00+00:001678.72Granular MatterHow a solid object penetrates granular matter near boundaries has been rarely studied. In this seminar I will describe detailed experiments showing how a cylindrical object penetrates into a granular bed near a vertical wall. We find two kinds of motion: the intruder separates from the wall as it sinks, and rotates around its symmetry axis. The repulsion is thought to be caused by the asymmetrical loading of force chains, which are stronger between the object and the wall. The rotation is associated to the tangential friction between the grains and the intruder --a fact that has been neglected in previous research. We introduce simple phenomenological models to explain both motions, and DEM simulations to further explore the parameter space. Moreover, we experimentally show the analogy between the penetration of two intruders released side-by-side far from boundaries, and one intruder released near a vertical wall, which suggests the idea that the method of images might be useful in the field of granular matter.https://cassyni-user-files-prod.s3.amazonaws.com/RDsRnpxPVa7ZBHv5UcmL7g https://cassyni.com/slides/outline/S2LPTWZeMh9TGcLJe5jpqK https://cassyni.com/events/S2LPTWZeMh9TGcLJe5jpqK/abstract https://cassyni-user-files-prod.s3.amazonaws.com/JzfGPitkwms4ZA2C7yghiW https://cassyni.com/events/S2LPTWZeMh9TGcLJe5jpqK?videoPreview=1 Learning to Design Efficient Logic Circuitsnohttps://cassyni.com/events/S2LPTWZeMh9TGcLJe5jpqK?videoPreview=12023-09-12T09:30:00+00:001890.88HiPEDS CentreLogic synthesis is the problem of designing a circuit composed of logic gates (e.g., AND, OR, etc.) from an abstract specification of a function (e.g., a truth table) that the circuit should implement. It is how the basic building blocks of modern chips are designed, and is therefore one of the fundamental problems of modern chip design. This is a challenging problem, because in addition to fidelity to the specification, logic synthesis must also take into account the efficiency of the design when implemented in hardware. We propose a machine learning-driven approach to design efficient logic circuits, composed of two stages: 1. Generate a design that optimizes correctness with respect to the specification. 2. Optimize the efficiency of the design while maintaining functional equivalence with respect to the design from the first stage. We compared our technique to other competitive approaches by participating in the IWLS 2023 Programming Contest and achieved the best solution on 82% of circuit design problems in the competition. These results demonstrate that the proposed approach can be used to design logic circuits that are both functionally correct and competitive with human-designed circuits.https://cassyni-user-files-prod.s3.amazonaws.com/JzfGPitkwms4ZA2C7yghiW https://cassyni.com/slides/outline/5H71WoPbvTtC8ct2MxpUwo https://cassyni.com/events/5H71WoPbvTtC8ct2MxpUwo/abstract https://cassyni-user-files-prod.s3.amazonaws.com/9oDL1ReHoB92bBMckQdAHC https://cassyni.com/events/5H71WoPbvTtC8ct2MxpUwo?videoPreview=1 An Open Source Deep Learning Toolkit for Perception & Cognition in Robotics and Other Areasnohttps://cassyni.com/events/5H71WoPbvTtC8ct2MxpUwo?videoPreview=12022-06-09T12:30:00+00:002363.48Journal on Image and Video ProcessingDeep Learning (DL) has provided powerful tools for a wide range of different application areas, including visual perception and cognition in robotics, media monitoring, image analysis, and others. However, deploying DL tools in real applications comes with several challenges, since DL requires different pipelines compared to traditional computer vision tools. For example, specialized software frameworks, along with the appropriate hardware should be used for training and inference, since DL models are often too resource-intensive to be directly deployed. This issue is even more important in embedded applications, such as robotics and drone vision where significant computational power and energy constraints exist. Furthermore, the fragmentation of the DL landscape can further slow down their integration, since models produced with different tools are often not interoperable. At the same time, DL tools are typically designed to follow a static inference paradigm. However, many systems can provide active perception capabilities that are usually not used by the current generation of DL tools. In this talk, we will discuss the aforementioned challenges and present the Open Deep Learning Toolkit for Robotics (OpenDR) which aims to overcome many of these limitations that occur in robotics and many other areas, focusing on visual perception applications. As part of the talk, we will also briefly showcase practical examples of using the OpenDR toolkit, discussing how tools can be optimized and adapted to different inference platforms that are often used.https://cassyni-user-files-prod.s3.amazonaws.com/9oDL1ReHoB92bBMckQdAHC https://cassyni.com/events/UVaQgvoGYyuwdYosBmeTZF/seminar/qa https://cassyni.com/slides/outline/UVaQgvoGYyuwdYosBmeTZF https://cassyni.com/events/UVaQgvoGYyuwdYosBmeTZF/abstract https://cassyni-user-files-prod.s3.amazonaws.com/PT62jbQPhf2JQwtXSYGop https://cassyni.com/events/UVaQgvoGYyuwdYosBmeTZF?videoPreview=1 Celebrating Editorial Impact in 2023nohttps://cassyni.com/events/UVaQgvoGYyuwdYosBmeTZF?videoPreview=12023-12-14T09:00:00+00:003834.72Topics at the heart of our communityThis year, Editors have worked on a number of initiatives that have made an impact on their journals; from Editorial Board development, to supporting growth, increasing diversity, and the impact of new collections- we have a lot to celebrate!https://cassyni-user-files-prod.s3.amazonaws.com/PT62jbQPhf2JQwtXSYGop https://cassyni.com/events/7kM2kDdE7kegVZMauej7fj/abstract https://cassyni-user-files-prod.s3.amazonaws.com/XghoPF5QcBVajdyMvCJ48e https://cassyni.com/slides/outline/4HooRS6Z3Yn3Ts42FzMA8u https://cassyni.com/events/4HooRS6Z3Yn3Ts42FzMA8u/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Va8xq1xYwNFb2KAVUqxykA https://cassyni.com/events/4HooRS6Z3Yn3Ts42FzMA8u?videoPreview=1 Designing Diversity for Sustained Innovationnohttps://cassyni.com/events/4HooRS6Z3Yn3Ts42FzMA8u?videoPreview=12023-12-18T16:00:00+00:004845.84DeSci FoundationThe wisdom of crowds hinges on the independence and diversity of their members’ information and approach. Here I explore how the wisdom of scientific, technological and business crowds for sustained discovery and invention operate through a process of collective abduction—the collision of deduction and induction—wherein unexpected findings stimulate innovators to forge new insights to make the surprising unsurprising. Drawing on tens of millions of research papers and patents across the life sciences, physical sciences and patented inventions, here I show that surprising designs and discoveries are the best predictor of outsized success and that surprising advances systematically emerge across, rather than within researchers or teams; most commonly when innovators from one field surprisingly publish problem-solving results to an audience in a distant and diverse other. This scales insights from my prior work that shows how across innovators, teams and fields, connection and conformity is associated with reduced replication and impeded innovation. Using these principles, I simulate processes of scientific and technological search to demonstrate the relationship between crowded fields and constrained collective inferences, and I illustrate how inverting the traditional artificial intelligence approach to avoid rather than mimic human search enables the design of diversity that systematically violates established field boundaries and is associated with marked success of innovation predictions. I conclude with a discussion of prospects and challenges in a connected age for sustainable innovation through the design and preservation of difference. https://cassyni-user-files-prod.s3.amazonaws.com/Va8xq1xYwNFb2KAVUqxykA https://cassyni.com/slides/outline/FA56SUL6hcxWz8t3sXar5j https://cassyni.com/events/FA56SUL6hcxWz8t3sXar5j/abstract https://cassyni-user-files-prod.s3.amazonaws.com/k1ZP7RUh98AtKWQk1Jykz https://cassyni.com/events/FA56SUL6hcxWz8t3sXar5j?videoPreview=1 A Tale of Three Coauthors: Comparison of Ising Modelsnohttps://cassyni.com/events/FA56SUL6hcxWz8t3sXar5j?videoPreview=12023-09-21T15:00:00+00:004458.0Journal of Mathematical SciencesOn Friday, Jan 14, 2022, I had a draft of a single author paper intended for the Lieb Festschrift. Six days later, the paper had three coauthors. This talk will explain the interesting story, expose some underlying machinery and sketch the proof of a lovely inequality on certain finite sums.https://cassyni-user-files-prod.s3.amazonaws.com/k1ZP7RUh98AtKWQk1Jykz https://cassyni.com/events/9iwSvxDKsasSbGdpGcb46H/seminar/qa https://cassyni.com/slides/outline/9iwSvxDKsasSbGdpGcb46H https://cassyni.com/events/9iwSvxDKsasSbGdpGcb46H/abstract https://cassyni-user-files-prod.s3.amazonaws.com/JNHJ28eV1LVA1EQKANqLsp https://cassyni.com/events/9iwSvxDKsasSbGdpGcb46H?videoPreview=1 Solution discovery in fluid dynamics using neural networksnohttps://cassyni.com/events/9iwSvxDKsasSbGdpGcb46H?videoPreview=12023-12-01T16:00:00+00:003778.84Journal of Fluid MechanicsI will discuss two examples of utilizing neural networks (NN) to find solutions to partial differential equations (PDEs). The first concerns the search for self-similar blow-up solutions of the Euler equations (Wang-Lai-Gómez-Serrano-Buckmaster, Phys. Rev. Lett. 2023). The second application uses PDE-constrained NNs as an inverse method in geophysics. Whether an inviscid incompressible fluid, described by the 3-dimensional Euler equations, can develop singularities in finite time is an open question in mathematical fluid dynamics. We employ NNs to find a numerical self-similar blow-up solution for the incompressible 3-dimensional Euler equations with a cylindrical boundary. In the second part of the talk, I will discuss how PDE-constrained NNs trained with real world data from Antarctica can help discover the fluid rhoelogy that govern ice-shelf dynamics. Despite its importance in governing the flow of glaciers into the ocean, the rheology of glacial ice, a crucial material property, cannot be directly measured in the field. Several geophysical-scale phenomena could potentially cause the laboratory-derived rheology of ice to deviate from itss behavior in the field. Using NN with data measured from space, here we infer glacial rheology that differ from those commonly assumed in climate simulations. This demonstrates the need to reassess the rheology of geophysical complex fluids beyond the laboratory setting.https://cassyni-user-files-prod.s3.amazonaws.com/JNHJ28eV1LVA1EQKANqLsp https://cassyni.com/events/N5BBCfuLFPe2dRa2XY6Ds3/abstract https://cassyni-user-files-prod.s3.amazonaws.com/GLCW1wYWRYBndDE9PXWPXL https://cassyni.com/events/YSpVHf1EsNCBJQZZqCyZBB/seminar/qa https://cassyni.com/slides/outline/YSpVHf1EsNCBJQZZqCyZBB https://cassyni.com/events/YSpVHf1EsNCBJQZZqCyZBB/abstract https://cassyni-user-files-prod.s3.amazonaws.com/49qaq7BxX3QGeDwvK7QH4z https://cassyni.com/events/YSpVHf1EsNCBJQZZqCyZBB?videoPreview=1 Distributed wastewater treatment and reuse as a water supply: impact on urban water system resiliencenohttps://cassyni.com/events/YSpVHf1EsNCBJQZZqCyZBB?videoPreview=12024-01-11T13:00:00+00:002454.4Nature WaterWater and wastewater systems are critical infrastructure whose disruption directly threatens public health, economic growth, as well as the reliability and functionality of other critical infrastructure including power, transportation, and health care systems. Hybrid urban water supply systems that combine conventional, centralized water sources with distributed sources such as reclaimed wastewater have great potential to reduce energy consumption while minimizing freshwater withdrawal. In this study, we quantitatively analyze the impact of distributed direct potable reuse of municipal wastewater on the resiliency of urban water supply systems using the City of Houston’s municipal water system as a testbed. A hybrid system configuration that supplements centralized drinking water supplies with reclaimed wastewater from distributed treatment and reuse systems exhibits lower severity, range of impact, and duration of substandard performance compared to the centralized design. Benefits are most prominent in areas more susceptible to a variety of systemic or localized disruptions in the centralized system. The analyses reveal vulnerable components in the current system and identify appropriate mitigation strategies that account for local geographical constraints. Findings from this study provide quantitative evidence for the risks current urban water systems face, underscoring the necessity to consider alternative system configurations for better performance and higher resilience.https://cassyni-user-files-prod.s3.amazonaws.com/49qaq7BxX3QGeDwvK7QH4z https://cassyni.com/slides/outline/H8h8jqS5rp71EKrgX4PE8u https://cassyni.com/events/H8h8jqS5rp71EKrgX4PE8u/abstract https://cassyni-user-files-prod.s3.amazonaws.com/DPTU6szjmKoWqDxY4ZvdrE https://cassyni.com/events/H8h8jqS5rp71EKrgX4PE8u?videoPreview=1 Introducing Transformative Plant Biotechnology: Considering B vitamin metabolism in plants, and for food and nutritional securitynohttps://cassyni.com/events/H8h8jqS5rp71EKrgX4PE8u?videoPreview=12023-09-20T13:45:00+00:001923.16The New Phytologist FoundationVitamins (as vital organic micronutrients for animals) were first discovered over a century ago. Plants biosynthesize these compounds de novo and are a predominant source of vitamins for humans. While gathering the wealth of information on the impact of vitamins in human health and disease alleviation, the biology of these compounds in plants themselves was largely sidelined. Within the vitamin classes, the B vitamins are renowned for their essential biochemical function as coenzymes in metabolism. However, each B vitamin is a family of compounds and little is known about the importance of maintaining individual family homeostasis. Plants undergo metabolic reprograming in response to environmental perturbations, thus regulation of vitamin homeostasis may be an important facet of metabolic homeostasis, influencing plant growth and health. In this talk, I will present examples of aspects that we uncovered that relate to the integration of B vitamins into plant growth and nutrient status. An application of this work leads to the possibility of overproduction of these compounds to enhance plant nutrient content. In this context, I will also discuss our work on enhancing the levels of particular B vitamins in consumed parts of crop plants for biofortification purposes.https://cassyni-user-files-prod.s3.amazonaws.com/DPTU6szjmKoWqDxY4ZvdrE https://cassyni.com/slides/outline/Kbw9yFfi46sVbGLF4kHrrq https://cassyni.com/events/Kbw9yFfi46sVbGLF4kHrrq/abstract https://cassyni-user-files-prod.s3.amazonaws.com/FyrtbU9F4yi5HdX6ek28VL https://cassyni.com/events/Kbw9yFfi46sVbGLF4kHrrq?videoPreview=1 Introducing Transformative Plant Biotechnology: Exploiting posttranslational modification mechanisms to boost stress resilience in cropsnohttps://cassyni.com/events/Kbw9yFfi46sVbGLF4kHrrq?videoPreview=12023-09-22T10:45:00+00:001855.84The New Phytologist FoundationNo abstracthttps://cassyni-user-files-prod.s3.amazonaws.com/FyrtbU9F4yi5HdX6ek28VL https://cassyni.com/events/8F3t2AJXMw4H8ioiuRgFkq/seminar/qa https://cassyni.com/events/8F3t2AJXMw4H8ioiuRgFkq/abstract https://cassyni-user-files-prod.s3.amazonaws.com/DvV77ZhGRWXHjurnWWpcjg https://cassyni.com/events/8F3t2AJXMw4H8ioiuRgFkq?videoPreview=1 LUA Celebration of the 6th edition of the World Logic Daynohttps://cassyni.com/events/8F3t2AJXMw4H8ioiuRgFkq?videoPreview=12024-01-14T15:00:00+00:006107.96Logica UniversalisThe celebration will be held from Cusco (Peru) during [SALOME 1: the first South American LOgic MEeting ](https://www.salome2024.org) Round Table with, Luis Felipe Alegre, Jasmin Özel, Juan Redmond, Philip Welch Interview with Jean-Yves Beziau by Caroline Pires Ting [Kurt Gödel: Deceased on the World Logic Day ! ](https://www.logica-universalis.org/wld6)https://cassyni-user-files-prod.s3.amazonaws.com/DvV77ZhGRWXHjurnWWpcjg https://cassyni.com/slides/outline/T1fDfWNadyBL5qri2d9bGq https://cassyni.com/events/T1fDfWNadyBL5qri2d9bGq/abstract https://cassyni-user-files-prod.s3.amazonaws.com/NKtyWsDKFLUNtb5athfvxe https://cassyni.com/events/T1fDfWNadyBL5qri2d9bGq?videoPreview=1 Biomimetic Structural Optimization Method: New paradigm for shape and topology optimizationnohttps://cassyni.com/events/T1fDfWNadyBL5qri2d9bGq?videoPreview=12021-06-14T12:00:00+00:003546.48Discover Applied SciencesThe trabecular bone adapts its form to mechanical loads and is able to form lightweight but very stiff structures. In this sense, it is a problem (for the Nature) similar to the structural optimization, especially the topology optimization. The structural optimization system based on shape modification using shape derivative [1] will be presented. Structural evolution during the structural optimization procedure is based on the adaptive remodeling of the trabecular bone and is independent of domain selection. In general the problem of stiffest design (compliance minimization) has no solution. If the volume of the object is increasing, the compliance is decreasing. Thus, in the standard approach to the energy based topology optimization the additional constraint has to be added. Usually the volume of the material is limited. But with such an assumption the optimization procedure does not include any criteria for stress. In case of the biomimetic approach presented here, the role of the additional constraint plays the strain energy density on the structural surface (which is between two assumed levels forming the insensitivity zone) and the volume or structural mass results from the optimization procedure. The variational approach to shape optimization in linearized elasticity is used in order to improve convergence of a heuristic algorithm. The method is enhanced to handle the problem of structural optimization under multiple loads [2]. The new approach does not require volume constraints. Instead of imposing volume constraints, shapes are parameterized by the assumed strain energy density on the structural surface.https://cassyni-user-files-prod.s3.amazonaws.com/NKtyWsDKFLUNtb5athfvxe https://cassyni.com/slides/outline/5mnEg7Z1mHN1x5sYA4wT81 https://cassyni.com/events/5mnEg7Z1mHN1x5sYA4wT81/abstract https://cassyni-user-files-prod.s3.amazonaws.com/2LvphBPr6AZ2pVdH9k8Vq8 https://cassyni.com/events/5mnEg7Z1mHN1x5sYA4wT81?videoPreview=1 Present and Future of the Conformal Bootstrapnohttps://cassyni.com/events/5mnEg7Z1mHN1x5sYA4wT81?videoPreview=12023-11-07T12:00:00+00:005268.28Physics ReportsI will start by reviewing the most notable results of the numerical conformal bootstrap, as applied to conformal field theories (CFTs) in condensed matter, particle physics, and quantum gravity. This includes the most precise determination of critical exponents for the superfluid Helium transition, as well as the first non-perturbative calculation of the low-lying spectrum of a non-abelian gauge theory, which also has a holographic interpretation. I will then present outstanding problems, both general principles and specific physical systems, that the bootstrap would like to tackle in the next few years.https://cassyni-user-files-prod.s3.amazonaws.com/2LvphBPr6AZ2pVdH9k8Vq8 https://cassyni.com/events/3JZqZKqGyMXFjd6NtwyG2h/seminar/qa https://cassyni.com/slides/outline/3JZqZKqGyMXFjd6NtwyG2h https://cassyni.com/events/3JZqZKqGyMXFjd6NtwyG2h/abstract https://cassyni-user-files-prod.s3.amazonaws.com/UtbqJcYsAL4jrqgs21PPBt https://cassyni.com/events/3JZqZKqGyMXFjd6NtwyG2h?videoPreview=1 End-Permian Mass Extinction: Patterns, Processes, and Lessons for the 21st Centurynohttps://cassyni.com/events/3JZqZKqGyMXFjd6NtwyG2h?videoPreview=12024-03-21T17:30:00+00:002006.04Cambridge PrismsThe end-Permian mass extinction, which occurred approximately 252 million years ago, was the most severe biodiversity crisis in the history of animal life. In the marine fossil record, about half of known animal families and 80% of genera were lost. Heavily calcified taxa with limited development of respiratory and circulatory systems are disproportionately represented among the victims. The geological record of the extinction interval contains chemical evidence, some based on newly developed proxies, of rapid global warming, ocean acidification, and ocean deoxygenation. High-precision age dating shows that eruption of the Siberian Traps large igneous province occurred during the extinction interval, providing a plausible mechanism for rapid and extreme environmental change. Earth system models can now replicate the environmental changes indicated by chemical proxies and the habitat space available to marine animals can be represented in these models based on a ratio of oxygen supply to metabolic demand. The model representation of biological response to global change predicts the observed gradient in extinction intensity from equator to pole, suggesting that temperature-induced hypoxia was a major direct cause of population collapse. Parallels between end-Permian and Anthropocene environmental changes can enable calibration of models designed to predict responses of the marine biosphere to environmental change anticipated over the next few centuries.https://cassyni-user-files-prod.s3.amazonaws.com/UtbqJcYsAL4jrqgs21PPBt https://cassyni.com/slides/outline/4nV2akFxtNFsHL3Y46U8K7 https://cassyni.com/events/4nV2akFxtNFsHL3Y46U8K7/abstract https://cassyni-user-files-prod.s3.amazonaws.com/9XKkbfmxiMRduUDpiAB81c https://cassyni.com/events/4nV2akFxtNFsHL3Y46U8K7?videoPreview=1 Viscous froth model applied to multiple topological transformations of bubbles flowing in a channel: three-bubble casenohttps://cassyni.com/events/4nV2akFxtNFsHL3Y46U8K7?videoPreview=12023-11-15T13:00:00+00:002777.24Royal Society PublishingThe flow of just three bubbles along a channel [1] captures many of the features of foam flow in porous media. Here a situation is considered in which bubbles are arranged in a staircase fashion zig-zagging across a channel (two bubbles attaching to one channel wall, but just a single bubble attaching to the other). The resulting topological asymmetry also implies asymmetry in the drag forces associated with foam film motion. When the system is driven fast enough, the imbalance in drag can cause the staircase structure to break. Bubbles then exchange neighbours during a so called T1 topological transformation. Previous work [2,3] has shown that the three-bubble system is sufficiently complex that it admits different ``flavours'' of T1 transformation, variously called T1c, T1u, T1l, and so on. Which flavour of T1 is selected depends on bubble sizes relative to channel size and also upon imposed driving pressure. All that previous work however focussed solely on the first T1 that the three-bubble system encountered [2,3]. The present contribution therefore examines the entire sequence of T1 transformations that a three-bubble system can undergo [1]. It is revealed that that the daughter states produced after the first T1 tend themselves to be unstable, meaning they are short-lived intermediates which break again via additional T1 transformations. Eventually the three bubble system reaches a stable final configuration that can then simply flow along. However, like the T1 transformations that produced them, these final configurations themselves come in different flavours. Which flavour is selected depends on bubble size relative to channel size and upon imposed driving pressure. A feature common to all the final configurations however is topological symmetry: in the final flowing structure, equal numbers foam films attach to either channel wall. One configuration which seems to be particularly favoured is a state in which just two bubbles stacked across the width of the channel continue flowing along, with a third bubble left behind altogether. This two-bubble configuration is found to have high mobility: not just higher mobility than the original parent three-bubble configuration, but also higher than any other competitor final configuration. https://cassyni-user-files-prod.s3.amazonaws.com/9XKkbfmxiMRduUDpiAB81c https://cassyni.com/slides/outline/CCD6GzxqUEZhmua11yKrj7 https://cassyni.com/events/CCD6GzxqUEZhmua11yKrj7/abstract https://cassyni-user-files-prod.s3.amazonaws.com/PwY2TNaQyQNFyaMro8ntm4 https://cassyni.com/events/CCD6GzxqUEZhmua11yKrj7?videoPreview=1 Modelling the interplay between zonal winds, waves and turbulence: application to gas giantsnohttps://cassyni.com/events/CCD6GzxqUEZhmua11yKrj7?videoPreview=12023-06-14T12:00:00+00:002685.72Leeds Institute for Fluid DynamicsThe ongoing NASA’s Juno mission is providing stunning observations of Jupiter, which illustrate the complex fluid dynamics involved on the gas giant. Among others, Jupiter’s atmosphere exhibits multiple persistent vortices embedded within strong east-west winds called zonal jets, both features being part of an intense turbulent flow. In this talk, I will present laboratory experiments complemented by numerical and theoretical analyses to better understand the emergence and properties of Jovian zonal winds. I will present an experimental setup where dominant zonal jets emerge spontaneously from a rapidly rotating turbulent flow with a topographic beta-effect. I will demonstrate the essential role of Rossby waves in the emergence and nonlinear saturation of the jets, illustrated by a transition between two regimes of jets involving a Rossby waves resonance. By studying the inhomogeneous and anisotropic properties of the turbulent flow, and using complementary quasigeostrophic numerical simulations, I will show that these experiments are in the so-called zonostrophic regime, relevant to gas giants. Finally, I will discuss the final scale of equilibration of zonal winds using an analytical quasi-linear model of the interaction between Rossby waves and the mean flow. The features and mechanisms presented in this talk are not exclusive to gas giants, and our results aim at being generic and applicable to other fluid systems subject to analogous physical effects, such as oceans, atmospheres and planetary liquid cores.https://cassyni-user-files-prod.s3.amazonaws.com/PwY2TNaQyQNFyaMro8ntm4 https://cassyni.com/slides/outline/NZrQMz4k6D7rStZYKeDC3F https://cassyni.com/events/NZrQMz4k6D7rStZYKeDC3F/abstract https://cassyni-user-files-prod.s3.amazonaws.com/LEfzcFDygUDXSAeWybvwgA https://cassyni.com/events/NZrQMz4k6D7rStZYKeDC3F?videoPreview=1 A new approach to solving the Navier-Stokes equationsnohttps://cassyni.com/events/NZrQMz4k6D7rStZYKeDC3F?videoPreview=12021-05-06T15:00:00+00:003408.12Leeds Institute for Fluid DynamicsConsider a closed space-time boundary in an unbounded fluid governed by the incompressible time-dependent Navier-Stokes equations. A boundary integral representation for the velocity is formulated in four dimensional space-time and given by a (space-time) boundary integral distribution of Navier-Stokes Green’s functions (NSlets). The NSlet is shown to tend towards an Eulerlet in the near-field and a Stokeslet in the far-field. A radial spoke potential description for the inertia term is introduced to apply the divergence theorem in the Green’s integral theory. The exterior and interior problems are considered together where the velocity is continuous over the common boundary. The initial value problem solution is demonstrated to exist and be smooth. The velocity boundary integral representation is deformed into a far-field integral or equivalently into a near-field integral where the NSlet becomes asymptotically smooth. Since the velocity is smooth, then the pressure is also smooth from the Helmholtz decomposition. The steady and two-dimensional cases are then given as local approximations in space and time, reducing to standard Stokeslet, Oseenlet and Eulerlet descriptions. Finally, an experiment is proposed to test the theory by inflating and deflating a spherical balloon tracing out a space-time ball, using a hot-wire probe to measure velocity.https://cassyni-user-files-prod.s3.amazonaws.com/LEfzcFDygUDXSAeWybvwgA https://cassyni.com/events/L6e1FCM1JHH6ERnP4XEzww/seminar/qa https://cassyni.com/slides/outline/L6e1FCM1JHH6ERnP4XEzww https://cassyni.com/events/L6e1FCM1JHH6ERnP4XEzww/abstract https://cassyni-user-files-prod.s3.amazonaws.com/PaeuA5YTBnjxxChD57kZoU https://cassyni.com/events/L6e1FCM1JHH6ERnP4XEzww?videoPreview=1 Biomimetic and Natural Product Synthesisnohttps://cassyni.com/events/L6e1FCM1JHH6ERnP4XEzww?videoPreview=12024-03-27T08:00:00+00:006405.8Thieme GroupInspired or learning from nature is always a great approach to solve problems. In terms of natural product synthesis, which is always challenging, it is wise to imitate nature’s way to overcome difficulty. Biomimetic synthesis has been recognized for its remarkable ability to simplify the synthetic processes toward complex natural targets. In this Thieme Cheminar, our speakers will discuss their recent results in this field.https://cassyni-user-files-prod.s3.amazonaws.com/PaeuA5YTBnjxxChD57kZoU https://cassyni.com/slides/outline/P4W1QfiGXffuSf6Rv5VzJZ https://cassyni.com/events/P4W1QfiGXffuSf6Rv5VzJZ/abstract https://cassyni-user-files-prod.s3.amazonaws.com/9sPjoWVmRLjyUTkybmjRYi https://cassyni.com/events/P4W1QfiGXffuSf6Rv5VzJZ?videoPreview=1 SMIwiz: An integrated toolbox for multidimensional seismic modelling and imagingnohttps://cassyni.com/events/P4W1QfiGXffuSf6Rv5VzJZ?videoPreview=12023-12-21T04:00:00+00:002118.32Computer Physics CommunicationsI contribute an open source software - SMIwiz, which integrates seismic modelling, reverse time migration (RTM), and full waveform inversion (FWI) into a unified computer implementation. SMIwiz has the machinery to do both 2D and 3D simulation in a consistent manner. The package features a number of computational recipes for efficient calculation of imaging condition and inversion gradient: a dynamic evolving computing box to limit the simulation cube and a well-designed wavefield reconstruction strategy to reduce the memory consumption when dealing with 3D problems. The modelling in SMIwiz runs independently: each shot corresponds to one processor in a bijective manner to maximize the scalability. A batchwise job scheduling strategy is designed to handle large 3D imaging tasks on computer with limited number of cores. The viability of SMIwiz is demonstrated by a number of applications on benchmark models.https://cassyni-user-files-prod.s3.amazonaws.com/9sPjoWVmRLjyUTkybmjRYi https://cassyni.com/events/R36RbQJNHVtfYNNfH3Mvj7/abstract https://cassyni-user-files-prod.s3.amazonaws.com/k6N3mm6SUwnR5eKZ93HM8 https://cassyni.com/slides/outline/TWLSppXzUnf9uJrDpjGZT3 https://cassyni.com/events/TWLSppXzUnf9uJrDpjGZT3/abstract https://cassyni-user-files-prod.s3.amazonaws.com/6mttXGKFStN4Y4zbS4f8q4 https://cassyni.com/events/TWLSppXzUnf9uJrDpjGZT3?videoPreview=1 Chondroitin Sulfate Proteoglycans Are De Facto Cellular Receptors for Human Papillomavirus 16 under High Serum Conditionsnohttps://cassyni.com/events/TWLSppXzUnf9uJrDpjGZT3?videoPreview=12023-11-16T14:00:00+00:002556.36Center for Cancer TrainingHeparan sulfate proteoglycans (HSPGs) have previously been identified as the predominant host attachment factors used by human papillomaviruses (HPVs) prior to infection. Here, we demonstrate that in vitro, HPV binding to HSPGs is strongly dependent on the surrounding experimental conditions, including the concentration of fetal bovine serum (FBS). We found that high concentrations of FBS can block HSPG-binding sites and cause a dependence on sulfated chondroitin sulfate proteoglycans (CSPGs) as alternative initial viral receptors. Further, we demonstrate that use of a human-derived alternative to FBS, human platelet lysate, also occludes HSPG-dependent binding, causing a shift toward CSPGs for viral attachment. As HPV infection of basal epithelial cells is thought to occur at sites of microtrauma with exposure to high serum levels and platelet factors, these unexpected findings highlight a possible role for CSPGs as important cellular receptors for the binding and infectivity of HPV in vivo.https://cassyni-user-files-prod.s3.amazonaws.com/6mttXGKFStN4Y4zbS4f8q4 https://cassyni.com/slides/outline/2ovEWeBkXtyCjrZVJWgTmP https://cassyni.com/events/2ovEWeBkXtyCjrZVJWgTmP/abstract https://cassyni-user-files-prod.s3.amazonaws.com/WvxwxwcmTr56T2oa6FFY94 https://cassyni.com/events/2ovEWeBkXtyCjrZVJWgTmP?videoPreview=1 MGMT promoter methylation in 1p19q‑intact gliomasnohttps://cassyni.com/events/2ovEWeBkXtyCjrZVJWgTmP?videoPreview=12024-02-05T21:00:00+00:001613.08Journal of Neuro-OncologyJoin The Journal of Neuro Oncology's Editor-in-Chief, Dr. Jason Sheehan, and Associate Editor, Dr. Randy D'Amico, for a conversation with Dr. Tony Wang, Dr. Simon Cheng, Dr. Fabio Iwamoto, and Dr. Connor Kinslow to discuss their latest publication on MGMT promoter methylation in 1p19q-intact gliomas. https://cassyni-user-files-prod.s3.amazonaws.com/WvxwxwcmTr56T2oa6FFY94 https://cassyni.com/slides/outline/DgBXXgRJBy9gG8PWv3v9iD https://cassyni.com/events/DgBXXgRJBy9gG8PWv3v9iD/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Fdc5ULMnpHZAuuAiqB8o8S https://cassyni.com/events/DgBXXgRJBy9gG8PWv3v9iD?videoPreview=1 Bianalytic polynomial approximations, Nevanlinna domains and univalent functions in model spacesnohttps://cassyni.com/events/DgBXXgRJBy9gG8PWv3v9iD?videoPreview=12023-01-26T15:00:00+00:003275.48Journal of Mathematical SciencesIn the talk we plan to consider the problem on uniform approximation by bianalytic polynomials on compact sets in the complex plane. The obtained results in this problem are essentially based on the new special analytic property of bounded simply connected domain in the plane which is known nowadays as a concept of a Nevanlinna domain. We will discuss this concept, and consider its relations with the theory of model spaces (that is the subspaces of the Hardy space 𝑯𝟐, which are invariant with respect to the backward shift operator). More precisely we discuss the problem on whether such spaces contain bounded univalent functions and what are the possible boundary properties of bounded univalent functions belonging to model spaces.https://cassyni-user-files-prod.s3.amazonaws.com/Fdc5ULMnpHZAuuAiqB8o8S https://cassyni.com/events/ADeJCttd7mH3ES5xGPYCBP/seminar/qa https://cassyni.com/slides/outline/ADeJCttd7mH3ES5xGPYCBP https://cassyni.com/events/ADeJCttd7mH3ES5xGPYCBP/abstract https://cassyni-user-files-prod.s3.amazonaws.com/PHQYnv2zKH9kWELc2Cob1Q https://cassyni.com/events/ADeJCttd7mH3ES5xGPYCBP?videoPreview=1 Assessing the accuracy of OpenET satellite-based evapotranspiration data to support water resource and land management applicationsnohttps://cassyni.com/events/ADeJCttd7mH3ES5xGPYCBP?videoPreview=12024-02-22T13:00:00+00:002177.8Nature WaterThis talk will give an overview of the recent accuracy assessment of the [OpenET](https://etdata.org/) remote sensing evapotranspiration (ET) data production platform. OpenET ET data accuracy was evaluated using direct comparisons with high quality *in situ* ET observations from 152 stations (primarily eddy covariance systems) across the contiguous United States. https://cassyni-user-files-prod.s3.amazonaws.com/PHQYnv2zKH9kWELc2Cob1Q https://cassyni.com/events/CgtKSK8FK43XbNZWp5SpuK/seminar/qa https://cassyni.com/slides/outline/CgtKSK8FK43XbNZWp5SpuK https://cassyni.com/events/CgtKSK8FK43XbNZWp5SpuK/abstract https://cassyni-user-files-prod.s3.amazonaws.com/8QVhuWx5bnMnQhV9y1jvxe https://cassyni.com/events/CgtKSK8FK43XbNZWp5SpuK?videoPreview=1 Dynamics of helical vortices in the wake of asymmetric rotorsnohttps://cassyni.com/events/CgtKSK8FK43XbNZWp5SpuK?videoPreview=12024-06-19T15:00:00+00:002842.04Department of AeronauticsThe wakes behind rotors such as wind turbines, propellers, and helicopters are characterized by helical vortices shed from the blade tips, which can have detrimental effects on downstream structures. Helical vortices are subject to displacement instabilities that lead to pairing between adjacent vortex loops and eventually cause the vortices to break down. Certain modes of these instabilities can be triggered by an asymmetry in the rotor generating the vortices. In three-vortex systems, like those formed by many industrial rotors, the nonlinear vortex interactions are highly complex, introducing the need for a simple model to predict their dynamics. We here present a model for helical vortex systems based on an infinite strip of periodically repeating point vortices, whose motion can be computed using a single equation. This greatly simplified model is shown to accurately reproduce the helical vortex dynamics predicted by a more sophisticated filament model and observed in previous experiments on model rotors. The model is then used to investigate different types of vortex perturbations representing rotor asymmetries, such as a displacement of a vortex (achievable by varying the blade tip geometry in an experiment), or a change of circulation (by varying the pitch). The effectiveness of the different types of rotor asymmetries for triggering the pairing instability was also investigated experimentally, by testing various rotor configurations in a water channel. The findings of the current study can be used to design rotors that passively accelerate wake recovery and mitigate negative effects on downstream structures. Preliminary numerical results concerning the influence of rotor asymmetry on wind turbine wake interactions will be shown.https://cassyni-user-files-prod.s3.amazonaws.com/8QVhuWx5bnMnQhV9y1jvxe https://cassyni.com/events/WUFhDYw2WtuWkw5X5dBtdT/seminar/qa https://cassyni.com/slides/outline/WUFhDYw2WtuWkw5X5dBtdT https://cassyni.com/events/WUFhDYw2WtuWkw5X5dBtdT/abstract https://cassyni-user-files-prod.s3.amazonaws.com/92g9Yz8SGtsYEUviCczbU2 https://cassyni.com/events/WUFhDYw2WtuWkw5X5dBtdT?videoPreview=1 By a whisker: the sensory role of vibrissae in hovering flight in nectarivorous batsnohttps://cassyni.com/events/WUFhDYw2WtuWkw5X5dBtdT?videoPreview=12024-03-06T16:00:00+00:003097.92Royal Society PublishingWhiskers are important tactile structures widely used across mammals for a variety of sensory functions, but it is not known how bats—representing about a fifth of all extant mammal species—use them. Nectar-eating bats typically have long vibrissae (long, stiff hairs) arranged in a forward-facing brush-like formation that is not present in most non-nectarivorous bats. They also commonly use a unique flight strategy to access their food—hovering flight. Here we investigated whether these species use their vibrissae to optimize their feeding by assisting fine flight control. We used behavioural experiments to test if bats' flight trajectory into the flower changed after vibrissa removal, and phylogenetic comparative methods to test whether vibrissa length is related to nectarivory. We found that bat flight trajectory was altered after vibrissae removal and that nectarivorous bats possess longer vibrissae than non-nectivorous species, providing evidence of an additional source of information in bats’ diverse sensory toolkit.https://cassyni-user-files-prod.s3.amazonaws.com/92g9Yz8SGtsYEUviCczbU2 https://cassyni.com/slides/outline/RXmekiTn8KNVMqNB59UtuK https://cassyni.com/events/RXmekiTn8KNVMqNB59UtuK/abstract https://cassyni-user-files-prod.s3.amazonaws.com/wm6VW17o6fdxFbx2ivxjg https://cassyni.com/events/RXmekiTn8KNVMqNB59UtuK?videoPreview=1 SGLT2 Inhibition in Adults with Kidney Diseasenohttps://cassyni.com/events/RXmekiTn8KNVMqNB59UtuK?videoPreview=12022-04-05T14:00:00+00:003252.08Imperial College Renal and Transplant CentreNo abstracthttps://cassyni-user-files-prod.s3.amazonaws.com/wm6VW17o6fdxFbx2ivxjg https://cassyni.com/events/6GV5x4EK1TmcbFKg9qtbD7/abstract https://cassyni-user-files-prod.s3.amazonaws.com/V8mDXKKXGbaGNUhYviYJ9c https://cassyni.com/slides/outline/3oF4idzgpB15Z65th46ECu https://cassyni.com/events/3oF4idzgpB15Z65th46ECu/abstract https://cassyni-user-files-prod.s3.amazonaws.com/2VuhPGoLNyuHjrd7b16BpA https://cassyni.com/events/3oF4idzgpB15Z65th46ECu?videoPreview=1 Springer Nature's Research Communities: Connecting the Stories Behind the Researchnohttps://cassyni.com/events/3oF4idzgpB15Z65th46ECu?videoPreview=12024-03-26T09:00:00+00:00819.64Topics at the heart of our communityOur 42 Research Communities encompass the natural, applied and humanitarian disciplines, and boast a membership of over 42,000 researchers and science-interested readers. Join our next Spotlight On… event to learn how these platforms will provide our Editors and Authors alike with greater opportunities to connect and collaborate with your network.https://cassyni-user-files-prod.s3.amazonaws.com/2VuhPGoLNyuHjrd7b16BpA https://cassyni.com/slides/outline/G9TAsjAoncqwSmKhfQexM3 https://cassyni.com/events/G9TAsjAoncqwSmKhfQexM3/abstract https://cassyni-user-files-prod.s3.amazonaws.com/QixwYGxW11Qd1RUHrLtjsU https://cassyni.com/events/G9TAsjAoncqwSmKhfQexM3?videoPreview=1 Machine Learning and the Physical Worldnohttps://cassyni.com/events/G9TAsjAoncqwSmKhfQexM3?videoPreview=12021-05-05T10:00:00+00:004386.04Data-Centric Engineering JournalMachine learning technologies have underpinned the recent revolution in artificial intelligence. But at their heart, they are simply data driven decision making algorithms. While the popular press is filled with the achievements of these algorithms in important domains such as object detection in images, machine translation and speech recognition, there are still many open questions about how these technologies might be implemented in domains where we have existing solutions but we are constantly looking for improvements. Roughly speaking, we characterise this domain as “machine learning in the physical world”. How do we design, build and deploy machine learning algorithms that are part of a decision making system that interacts with the physical world around us? In particular, machine learning is a data driven endeavour, but real world systems are physical and mechanistic. In this talk we will introduce some of the challenges for this domain and and propose some ways forward in terms of solutions.https://cassyni-user-files-prod.s3.amazonaws.com/QixwYGxW11Qd1RUHrLtjsU https://cassyni.com/events/AiKXND42xaks3u5U4VfAMb/seminar/qa https://cassyni.com/slides/outline/AiKXND42xaks3u5U4VfAMb https://cassyni.com/events/AiKXND42xaks3u5U4VfAMb/abstract https://cassyni-user-files-prod.s3.amazonaws.com/VPFSMJCPbncqXpyyXYZujU https://cassyni.com/events/AiKXND42xaks3u5U4VfAMb?videoPreview=1 Plasticulture: Challenges and Opportunities.nohttps://cassyni.com/events/AiKXND42xaks3u5U4VfAMb?videoPreview=12024-04-19T13:00:00+00:003495.04Cambridge PrismsScope: This inaugural webinar event for Cambridge Prisms: Plastics will explore the use of plastics in agriculture; agriplastics, and the broader use of plastics in various aspects of agriculture, including crop production, soil management, irrigation, and protection of crops; plasticulture. Our Panel of leading experts with diverse experience and perspectives will explore the complexities of plastic in agriculture. More specifically, this event will examine its trade-offs, advantages, global impact, policy implications, and new sustainable alternatives. Plasticulture has revolutionised agriculture and its practices, whilst raising critical questions about environmental sustainability, social equity, and long-term viability. Can new technologies and new materials offer solutions for this industry that meet all stakeholders needs while promoting human health and ensuring equitable access to sustainable livelihoods?https://cassyni-user-files-prod.s3.amazonaws.com/VPFSMJCPbncqXpyyXYZujU https://cassyni.com/events/BCy8QthZQ3Jv3fcMevwxcu/seminar/qa https://cassyni.com/slides/outline/BCy8QthZQ3Jv3fcMevwxcu https://cassyni.com/events/BCy8QthZQ3Jv3fcMevwxcu/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Dw5BWnWst5yYqXoQ4bEPSN https://cassyni.com/events/BCy8QthZQ3Jv3fcMevwxcu?videoPreview=1 The philosophy of logic of John Corcorannohttps://cassyni.com/events/BCy8QthZQ3Jv3fcMevwxcu?videoPreview=12024-03-27T15:00:00+00:005871.04Logica UniversalisThis talk surveys the philosophy of logic of John Corcoran by focusing on some of its characteristic themes: his understanding of logic as formal epistemology articulating the ontic-epistemic distinction of classical metaphysics, the Socratic belief-knowledge distinction, and the Aristotelian truth-knowledge distinction; his conception of mathematical logic as instrumental when considering mathematical logics as models of underlying reasoning found in the practice of proof; his tireless search for a careful and successful communication in a community of thinkers eliminating ambiguity of key terms and embracing ethical values; his discussion of argumentations and logic as a philosophical realization of the previous dichotomies, allowing precise definitions of key concepts, such as, argument, argumentation, proof, deduction, fallacy, and paradox; finally, his recovering and articulation of the XIX century information-theoretic conception of validity, exploring its heuristic power in the study of omega arguments and suggesting the existence of different paradigms of logical consequence equally entrenched in the theory and practice of logic.https://cassyni-user-files-prod.s3.amazonaws.com/Dw5BWnWst5yYqXoQ4bEPSN https://cassyni.com/events/Mb4QKx3eTngh3zAUZrF2oo/seminar/qa https://cassyni.com/slides/outline/Mb4QKx3eTngh3zAUZrF2oo https://cassyni.com/events/Mb4QKx3eTngh3zAUZrF2oo/abstract https://cassyni-user-files-prod.s3.amazonaws.com/3Et6xJGd3AjPa7oZSCyFMG https://cassyni.com/events/Mb4QKx3eTngh3zAUZrF2oo?videoPreview=1 Demystifying Transfersnohttps://cassyni.com/events/Mb4QKx3eTngh3zAUZrF2oo?videoPreview=12024-04-23T14:00:00+00:002308.56Topics at the heart of our communityTransfers represent an important aspect for content retention strategy in all journals. This presentation outlines the main benefits - and opportunities for growth - provided by transfers for Springer Nature Editors and their journals. Armed with data and examples, we show that in the majority of cases, a rejection does not mean a manuscript isn't worthy of publication. One journal's rejection can truly be another’s opportunity.https://cassyni-user-files-prod.s3.amazonaws.com/3Et6xJGd3AjPa7oZSCyFMG https://cassyni.com/events/J8XB1AWyPap42HruvBs5Gy/seminar/qa https://cassyni.com/slides/outline/J8XB1AWyPap42HruvBs5Gy https://cassyni.com/events/J8XB1AWyPap42HruvBs5Gy/abstract https://cassyni-user-files-prod.s3.amazonaws.com/AhvFRpyHB7wfa92mx8Z2mt https://cassyni.com/events/J8XB1AWyPap42HruvBs5Gy?videoPreview=1 XPRIZE Water Scarcitynohttps://cassyni.com/events/J8XB1AWyPap42HruvBs5Gy?videoPreview=12024-09-10T12:00:00+00:002471.04ElsevierWater scarcity is an escalating global crisis that affects nearly one-fourth of the population, with predictions indicating that by 2030, demand will surpass supply by 40%. This looming crisis is predominantly impacting densely populated coastal cities and is exacerbated by the limited 0.5% of Earth's freshwater that is usable, strained further by rapid urbanization, population growth, and climate change. XPRIZE Water Scarcity, a $119 million, 5-year competition, aims to address these challenges by fostering innovative advancements in seawater desalination technology. As 70% of the planet is covered by oceans, which contain over 96% of global water resources, desalination offers a potential solution for transforming abundant seawater into a sustainable freshwater supply. However, existing desalination methods, while mature, have not seen significant innovation since the early 2000s and are often prohibitively expensive and environmentally unsustainable for widespread adoption. The competition is structured into three tracks to tackle these challenges: the development of a new desalination system capable of sustainably producing one million liters of potable water per day, the creation of novel membrane materials to enhance the efficiency and lifespan of reverse osmosis processes, and an ideas competition to reshape the global perception of water's value. Through these efforts, XPRIZE Water Scarcity seeks to catalyze a paradigm shift in desalination technology by making it more robust, affordable, and environmentally sustainable. This initiative not only aims to redefine the landscape of desalination on a global scale but also to ensure broader socio-economic equity and enhance global water management practices, creating a future where clean water is equitably and sustainably abundant. https://cassyni-user-files-prod.s3.amazonaws.com/AhvFRpyHB7wfa92mx8Z2mt https://cassyni.com/slides/outline/U1VFvqTUAjtNsorwRkdSQu https://cassyni.com/events/U1VFvqTUAjtNsorwRkdSQu/abstract https://cassyni-user-files-prod.s3.amazonaws.com/SSFz4vuy45H4cH6U9prgdc https://cassyni.com/events/U1VFvqTUAjtNsorwRkdSQu?videoPreview=1 AI/ML+Physics: Preview of Upcoming Modules and Bootcampsnohttps://cassyni.com/events/U1VFvqTUAjtNsorwRkdSQu?videoPreview=12024-02-22T10:00:00+00:001140.88Brunton LabThis video provides a brief preview of the upcoming modules and bootcamps in this series on Physics Informed Machine Learning. Topics include: (1) Parsimonious modeling and SINDy; (2) Physics informed neural networks (PINNs); (3) Operator methods, like DeepONets and Fourier Neural Operators; (4) Symmetries in physics and machine learning; (5) Digital Twin technology; and (6) Case studies in engineering. SLB acknowledges support from the National Science Foundation AI Institute in Dynamic Systems and from The Boeing Company.https://cassyni-user-files-prod.s3.amazonaws.com/SSFz4vuy45H4cH6U9prgdc https://cassyni.com/events/6mcGwSduJ454k3smZCRJG5/seminar/qa https://cassyni.com/slides/outline/6mcGwSduJ454k3smZCRJG5 https://cassyni.com/events/6mcGwSduJ454k3smZCRJG5/abstract https://cassyni-user-files-prod.s3.amazonaws.com/6vvL75dTQhWkiXKhiGqXQa https://cassyni.com/events/6mcGwSduJ454k3smZCRJG5?videoPreview=1 Giant sequoia (Sequoiadendron giganteum) in the UK: carbon storage potential and growth ratesnohttps://cassyni.com/events/6mcGwSduJ454k3smZCRJG5?videoPreview=12024-05-20T14:00:00+00:003444.4Royal Society PublishingGiant sequoias (Sequoiadendron giganteum) are some of the UK’s largest trees, despite only being introduced in the mid-nineteenth century. There are an estimated half a million giant sequoias and closely related coastal redwoods (Sequoia sempervirens) in the UK. Given the recent interest in planting more trees, partly due to their carbon sequestration potential and also their undoubted public appeal, an understanding of their growth capability is important. However, little is known about their growth and carbon uptake under UK conditions. Here, we focus on S. giganteum and use three-dimensional terrestrial laser scanning to perform detailed structural measurements of 97 individuals at three sites covering a range of different conditions, to estimate aboveground biomass (AGB) and annual biomass accumulation rates. We show that UK-grown S. giganteum can sequester carbon at a rate of 85 kg yr−1, varying with climate, management and age. We develop new UK-specific allometric models for S. giganteum that fit the observed AGB with r 2 > 0.93 and bias < 2% and can be used to estimate S. giganteum biomass more generally. This study provides the first estimate of the growth and carbon sequestration of UK open-grown S. giganteum and provides a baseline for estimating their longer-term carbon sequestration capacity.https://cassyni-user-files-prod.s3.amazonaws.com/6vvL75dTQhWkiXKhiGqXQa https://cassyni.com/events/XU2VFcz9Ewm1uWAW5R1Pwj/seminar/qa https://cassyni.com/slides/outline/XU2VFcz9Ewm1uWAW5R1Pwj https://cassyni.com/events/XU2VFcz9Ewm1uWAW5R1Pwj/abstract https://cassyni-user-files-prod.s3.amazonaws.com/3VCuUe6PFu1SQcT7gyZWd4 https://cassyni.com/events/XU2VFcz9Ewm1uWAW5R1Pwj?videoPreview=1 Spotlight On…Research Integrity: Current Challenges and How to Protect Your Journalnohttps://cassyni.com/events/XU2VFcz9Ewm1uWAW5R1Pwj?videoPreview=12024-05-30T08:00:00+00:003558.12Topics at the heart of our communityResearch integrity and publication ethics are about trust. How can you be confident that the research articles you are reading and citing are reliable? What can be done to protect the integrity of the publication record? Join Tim Kersjes, Head of Research Integrity, Resolutions, as he presents case studies of best practices, and explores the latest trends, tools, and challenges pertaining to issues of research integrity. Discover how the Springer Nature Research Integrity Group is supporting both our Editors and the wider research community in publishing robust and reliable research.https://cassyni-user-files-prod.s3.amazonaws.com/3VCuUe6PFu1SQcT7gyZWd4 https://cassyni.com/events/q8EUcAeuUY3LxARYiiJXw/seminar/qa https://cassyni.com/slides/outline/q8EUcAeuUY3LxARYiiJXw https://cassyni.com/events/q8EUcAeuUY3LxARYiiJXw/abstract https://cassyni-user-files-prod.s3.amazonaws.com/LMisCxkVJYg6v4TkbJ97eN https://cassyni.com/events/q8EUcAeuUY3LxARYiiJXw?videoPreview=1 Industrial Applicationsnohttps://cassyni.com/events/q8EUcAeuUY3LxARYiiJXw?videoPreview=12024-06-13T08:00:00+00:004931.52Nektar++ Development TeamThis session comprises the following talks 1. Current Capabilities for Implicit Large Eddy Simulations on Industrial Geometries using Spectral h/p Element Methods 2. Vortex dynamics in small scale vertical-axis wind turbine 3. Computational modelling of underwater ocean acoustic propagation with Nektar++https://cassyni-user-files-prod.s3.amazonaws.com/LMisCxkVJYg6v4TkbJ97eN https://cassyni.com/slides/outline/EBLLdhLmsvNuEdQEX5H2g5 https://cassyni.com/events/EBLLdhLmsvNuEdQEX5H2g5/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Uj7wDYmkMmRM8VzMhbg2fg https://cassyni.com/events/EBLLdhLmsvNuEdQEX5H2g5?videoPreview=1 Deep Delay Autoencoders Discover Dynamical Systems w Latent Variables: Deep Learning meets Dynamics!nohttps://cassyni.com/events/EBLLdhLmsvNuEdQEX5H2g5?videoPreview=12022-02-25T14:00:00+00:001040.0Brunton LabA central challenge in data-driven model discovery is the presence of hidden, or latent, variables that are not directly measured but are dynamically important. Takens' theorem provides conditions for when it is possible to augment these partial measurements with time delayed information, resulting in an attractor that is diffeomorphic to that of the original full-state system. However, the coordinate transformation back to the original attractor is typically unknown, and learning the dynamics in the embedding space has remained an open challenge for decades. Here, we design a custom deep autoencoder network to learn a coordinate transformation from the delay embedded space into a new space where it is possible to represent the dynamics in a sparse, closed form. We demonstrate this approach on the Lorenz, Rössler, and Lotka-Volterra systems, learning dynamics from a single measurement variable. As a challenging example, we learn a Lorenz analogue from a single scalar variable extracted from a video of a chaotic waterwheel experiment. The resulting modeling framework combines deep learning to uncover effective coordinates and the sparse identification of nonlinear dynamics (SINDy) for interpretable modeling. Thus, we show that it is possible to simultaneously learn a closed-form model and the associated coordinate system for partially observed dynamics.https://cassyni-user-files-prod.s3.amazonaws.com/Uj7wDYmkMmRM8VzMhbg2fg https://cassyni.com/events/K7r1DAKufrqvqXPKJjGqiV/seminar/qa https://cassyni.com/slides/outline/K7r1DAKufrqvqXPKJjGqiV https://cassyni.com/events/K7r1DAKufrqvqXPKJjGqiV/abstract https://cassyni-user-files-prod.s3.amazonaws.com/PAwmhPVW6CdhkbWMuNjohx https://cassyni.com/events/K7r1DAKufrqvqXPKJjGqiV?videoPreview=1 The Physics of Flowing Emulsions in Wall-Bounded Turbulencenohttps://cassyni.com/events/K7r1DAKufrqvqXPKJjGqiV?videoPreview=12024-12-17T15:00:00+00:002913.92Experiments in FluidsEmulsions are common in both natural and industrial contexts, and recently, significant attention has been directed toward understanding the dynamics of turbulent emulsions. In this talk, we discuss recent studies of emulsions in wall-bounded turbulent Taylor–Couette flow, focusing on the statistics of the dispersed phase and the system’s global momentum transport. First, we examine the size distribution and breakup mechanisms of dispersed droplets in turbulent emulsions with a low volume fraction of the dispersed phase. For systems with a high volume fraction of the dispersed phase, we explore the response of global momentum transport in the turbulent emulsion and its connection to droplet statistics. Finally, we discuss catastrophic phase inversions, which can occur when the dispersed phase volume fraction exceeds a critical value during dynamic emulsification.https://cassyni-user-files-prod.s3.amazonaws.com/PAwmhPVW6CdhkbWMuNjohx https://cassyni.com/slides/outline/GeaMs7aQ5D9PbZso4mBfQ1 https://cassyni.com/events/GeaMs7aQ5D9PbZso4mBfQ1/abstract https://cassyni-user-files-prod.s3.amazonaws.com/QrbcjLK3JGzvDqdhYuyHux https://cassyni.com/events/GeaMs7aQ5D9PbZso4mBfQ1?videoPreview=1 The Surprising Robustness and Computational Efficiency of Weak Form System Identificationnohttps://cassyni.com/events/GeaMs7aQ5D9PbZso4mBfQ1?videoPreview=12023-02-03T14:00:00+00:003774.24AI Institute in Dynamic SystemsRecent advances in data-driven modeling approaches have proven highly successful in a wide range of fields in science and engineering. In this talk, I will briefly discuss several ubiquitous challenges with the conventional model development / discretization / parameter inference / model revision loop that our methodology attempts to address. I will present our weak form methodology which has proven to have surprising performance properties. In particular, I will describe our equation learning (WSINDy) and parameter estimation (WENDy) algorithms. Lastly, I will discuss applications to several benchmark problems illustrating how our approach addresses several of the above issues and offers advantages in terms of computational efficiency, noise robustness, and modest data needs (in an online learning context).https://cassyni-user-files-prod.s3.amazonaws.com/QrbcjLK3JGzvDqdhYuyHux https://cassyni.com/events/VVThBWuvtUUMN2gTKqDjQ1/seminar/qa https://cassyni.com/slides/outline/VVThBWuvtUUMN2gTKqDjQ1 https://cassyni.com/events/VVThBWuvtUUMN2gTKqDjQ1/abstract https://cassyni-user-files-prod.s3.amazonaws.com/LU27kMzCS6zmC8jWt2ADLA https://cassyni.com/events/VVThBWuvtUUMN2gTKqDjQ1?videoPreview=1 Quantifying Statements (Why ‘Every Thing’ is Not ‘Everything’, Among Other ‘Thing’s)nohttps://cassyni.com/events/VVThBWuvtUUMN2gTKqDjQ1?videoPreview=12024-07-10T14:00:00+00:005271.04Logica UniversalisThe present paper wants to develop a formal semantics about a special class of formulas: quantifying statements, which are a kind of predicative statements where both subject- and predicate terms are quantifier expressions like ‘everything’, ‘something’, and ‘nothing’. After showing how talking about nothingness makes sense despite philosophical objections, I contend that there are two sorts of meaning in phrases including ‘thing’, viz. as an individual (e.g. ‘some thing’) or as a property (e.g. ‘something’). Then I display two kinds of logical forms for quantifying statements, depending on how these ‘thing’s are ordered into a whole predication. Finally, an algebraic semantics is proposed for the finite set of quantifying statements to order these into a (fragmentary) dodecagon of logical relations. The corresponding Sub-Model Semantics (hereafter: SMS) aims to update the usual theory of opposition whilst leading to a research program for other kinds of statements like categorical and even modal propositions.https://cassyni-user-files-prod.s3.amazonaws.com/LU27kMzCS6zmC8jWt2ADLA https://cassyni.com/slides/outline/Bi6KQH79gdcNCUAT4HUffs https://cassyni.com/events/Bi6KQH79gdcNCUAT4HUffs/abstract https://cassyni-user-files-prod.s3.amazonaws.com/8KjQ1FTWcKBmP6wpQUciW2 https://cassyni.com/events/Bi6KQH79gdcNCUAT4HUffs?videoPreview=1 Gene Editing in Agriculturenohttps://cassyni.com/events/Bi6KQH79gdcNCUAT4HUffs?videoPreview=12024-06-07T13:00:00+00:001676.2New Phytologist Foundation Powered by best-in-class technology, Pairwise tackles the challenges that our food and agricultural system face to achieve our goal of building a healthier world through better fruits and vegetables. Here, we describe work done by the Pairwise pipeline achieving agronomic improvements in corn and blackberry. In corn, we use DNA base editing to demonstrate a tunable increase in kernel row number, while in blackberry we use gene editing to achieve a compact structure and early flowering plants. Taken together, this work shows the power of gene editing and the Pairwise product pipeline to positively impact crop performance across various species.https://cassyni-user-files-prod.s3.amazonaws.com/8KjQ1FTWcKBmP6wpQUciW2 https://cassyni.com/events/Q4L3fzoA4SNxEd6fKCyqSd/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Fj9cSaVdmDJZaNh5AT5hKC https://cassyni.com/events/JdCQAUgPEQHsqkrRiHz3TB/seminar/qa https://cassyni.com/slides/outline/JdCQAUgPEQHsqkrRiHz3TB https://cassyni.com/events/JdCQAUgPEQHsqkrRiHz3TB/abstract https://cassyni-user-files-prod.s3.amazonaws.com/9vrsw2TpFs9oU1TsVSvA3G https://cassyni.com/events/JdCQAUgPEQHsqkrRiHz3TB?videoPreview=1 Sociophonetics and sexual orientation in the Wellington regionnohttps://cassyni.com/events/JdCQAUgPEQHsqkrRiHz3TB?videoPreview=12024-07-19T04:10:00+00:001635.44Linguistics and Applied Language StudiesThe phonetic correlates of women’s sexual orientation have long been debated by researchers, with research conducted on a variety of languages including English (e.g. Barron-Lutzross, 2018; Waksler, 2001), Cantonese (Wong and Tu, 2019), German, Portuguese, and Italian (Kachel et al., 2017), and in different dialect regions such as Northern California (Podesva and van Hofwegen, 2015), Minnesota (Munson et al., 2006), and London (Lawrence, 2014, cited in Levon, 2021). These studies often compare the speech of queer women to that of heterosexual women and their results vary by language, methodology, and dialect. The present study investigates the phonetic production of 9 self-identified queer women from the Wellington region of New Zealand. The term queer women is used here as an umbrella term for participants, who identify as cis gender LGBTQIA+ women, and as gender fluid or bigender. All participants describe attraction to people of their same gender and/or to multiple genders. This study aims to address the relationship between measures of queer identity and phonetic variation in three different laboratory speech tasks: a sentence reading task to ensure comparable phonetic materials were obtained from all speakers, a response elicitation about queer experiences in New Zealand to create a queer conversational space (see Levon, 2011), and an interactive map task to simulate instruction and collaboration with a partner. The phonetic variables in this study are average pitch and pitch range, as well as vowel dispersion and use of creaky voice. The initial stage of this research involved interviews with members of local queer communities to record presentations of queerness and gender identity in the Wellington region. Measures used to assess factors influencing the phonetic presentation of queer identity include self reports of identity but also variables elicited through surveys such as concealment motivation, identity uncertainty, and internalized homonegativity (see Mohr and Kendra, 2011). In addition, I also include measures from a secondary survey which explores feelings of connectedness and membership within queer communities (see Lin and Israel, 2012). These measures gauge the impact of community support and engagement on presentations of queer identities. This research contributes to the study of social identity and phonetic variation, including how linguistic variables can be used in the construction of queer identities in New Zealand.https://cassyni-user-files-prod.s3.amazonaws.com/9vrsw2TpFs9oU1TsVSvA3G https://cassyni.com/events/S2vTrjPFpGbiLLNtgAqmsB/seminar/qa https://cassyni.com/slides/outline/S2vTrjPFpGbiLLNtgAqmsB https://cassyni.com/events/S2vTrjPFpGbiLLNtgAqmsB/abstract https://cassyni-user-files-prod.s3.amazonaws.com/4UW7a1PS8p7gRooZd9pHzW https://cassyni.com/events/S2vTrjPFpGbiLLNtgAqmsB?videoPreview=1 Engaging with Research from Chinanohttps://cassyni.com/events/S2vTrjPFpGbiLLNtgAqmsB?videoPreview=12024-07-31T08:00:00+00:003188.84Topics at the heart of our communityRitu Dhand will be in conversation with special guests Enda Bergin (Editorial Director, Nature Communications), and Professor Bhekie Mamba (Editor-In-Chief, npj Clean Water), sharing experiences and insights into fostering connections with the research community in China, and how the impact of their efforts benefited their journals. This event serves as an expansion on our previous topic in November 2023: 'High Impact Research from China'.https://cassyni-user-files-prod.s3.amazonaws.com/4UW7a1PS8p7gRooZd9pHzW https://cassyni.com/slides/outline/Eg1Zo1WBijrj46PkKBPzrH https://cassyni.com/events/Eg1Zo1WBijrj46PkKBPzrH/abstract https://cassyni-user-files-prod.s3.amazonaws.com/8wZfqfAmNx3ZSp7RZGfNfp https://cassyni.com/events/Eg1Zo1WBijrj46PkKBPzrH?videoPreview=1 Practical tips for a great seminarnohttps://cassyni.com/events/Eg1Zo1WBijrj46PkKBPzrH?videoPreview=12024-07-15T14:00:00+00:002164.76Cassyni**What makes a great seminar?** [Dr Elodie Chabrol](https://www.elodiechabrol.com/), is a seasoned science communicator with extensive experience in delivering seminars and workshops on making science accessible and engaging to the public. With a PhD in neurogenetics and a rich background in science communication, including her role as the International Director of Pint of Science international, she has honed her skills in presenting complex scientific ideas in a relatable and entertaining manner. Her seminars are packed with practical tips on effective communication, drawn from her vast experience in both academic and public outreach settings. Today, she walks us through what she learnt: her recipe for a successful seminar.https://cassyni-user-files-prod.s3.amazonaws.com/8wZfqfAmNx3ZSp7RZGfNfp https://cassyni.com/events/9jXXLB2wLAKhezgQJhh189/abstract https://cassyni-user-files-prod.s3.amazonaws.com/4FgdaAnvep4YjfTpmkQHpr https://cassyni.com/events/N5mFbtiwhy6Hh9ccZdCAtu/seminar/qa https://cassyni.com/slides/outline/N5mFbtiwhy6Hh9ccZdCAtu https://cassyni.com/events/N5mFbtiwhy6Hh9ccZdCAtu/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Ddiun9pFYoJVLCQzPstNqt https://cassyni.com/events/N5mFbtiwhy6Hh9ccZdCAtu?videoPreview=1 An introduction to Dr Mark Griffin – a data scientist working with the Auckland Bioengineering Institute and the Mātai Medical Research Institutenohttps://cassyni.com/events/N5mFbtiwhy6Hh9ccZdCAtu?videoPreview=12024-08-20T04:00:00+00:003057.04The Auckland Bioengineering InstituteMark is a data scientist based in the Gold Coast Health and Knowledge Precinct Australia. He works with the Mātai Medical Research Institute in Gisborne (as an Industry Senior Research Fellow), and as a result with people from the ABI (particularly with Dr Vickie Shim). He expects to be visiting the ABI and Mātai two or three times a year in future. On this first visit Mark will give an overview of the broad range of methodologies that he is working with covering both statistics and mathematical modelling for magnetic resonance imaging (MRI). Mark is probably the most active presenter of short courses in statistics in Australia having now presented over 100 two-day and 50 five-day workshops. This one-hour seminar is a heavily condensed version of approximately 40 days of workshop material that he regularly presents. On future visits Mark will talk about more focussed areas of his work. In this whirlwind talk Mark will cover: • Regression – the difference between linear, logistic and Poisson regression • Regression assumptions – why can’t I just enter the names of my variables into the software and click “run”? • Factor analysis – what is factor analysis, what results are produced, what is rotation, and what is the difference between factor analysis and principal component analysis? • Cluster analysis – what is cluster analysis? What is the difference between k means and hierarchical clustering? • Longitudinal data analysis – how mixed effects models account for the temporal correlation in the data • Survival or time-to-event analysis – what is survival analysis? • Missing data – why can’t I just ignore the observations with missing data? How does multiple imputation help? • Structural Equation Modelling – what is SEM? • Data visualization – why do I need to invest time customizing my data visualization? • Geographical Information Systems (GIS) – what is GIS? • Survey design – why do survey questions need to be worded carefully? • Applications in imaging processing for magnetic resonance imaging – Finite Element Models, filtering • Data management for complex clinical trialshttps://cassyni-user-files-prod.s3.amazonaws.com/Ddiun9pFYoJVLCQzPstNqt https://cassyni.com/events/KcXENUVKWgKkezNq6qPoth/abstract https://cassyni-user-files-prod.s3.amazonaws.com/U9WqmECyCb6P527f5LnGB8 https://cassyni.com/events/XxjLXZfSV8AcYfce5BxY2q/seminar/qa https://cassyni.com/slides/outline/XxjLXZfSV8AcYfce5BxY2q https://cassyni.com/events/XxjLXZfSV8AcYfce5BxY2q/abstract https://cassyni-user-files-prod.s3.amazonaws.com/4xKuvM3MesJN2a9Fg87REE https://cassyni.com/events/XxjLXZfSV8AcYfce5BxY2q?videoPreview=1 Modelling and simulation of brinicle formationnohttps://cassyni.com/events/XxjLXZfSV8AcYfce5BxY2q?videoPreview=12024-09-19T14:00:00+00:003177.04Royal Society PublishingBelow the Arctic sea ice, under the right conditions, a flux of icy brine flows down into the sea. The icy brine has a much lower fusion point and is denser than normal seawater. As a result, it sinks while freezing everything around it, forming an ice channel called a brinicle (also known as ice stalactite). In this paper, we develop a mathematical model for this phenomenon, assuming cylindrical symmetry. The fluid is considered to be viscous and quasi-stationary. The heat and salt transport are weakly coupled to the fluid motion and are modelled with the corresponding conservation equations, accounting for diffusive and convective effects. Finite-element discretization is employed to solve the coupled system of partial differential equations. We find that the model can capture the general behaviour of the physical system and generate brinicle-like structures while also recovering dendrite composition, which is a physically expected feature aligned with previous experimental results. This represents, to our knowledge, the first complete model proposed that captures the global structure of the physical phenomenon even though it has some discrepancies, such as brine accumulation.https://cassyni-user-files-prod.s3.amazonaws.com/4xKuvM3MesJN2a9Fg87REE https://cassyni.com/slides/outline/5nNK5LNdDrpH1ov8CA3Q9s https://cassyni.com/events/5nNK5LNdDrpH1ov8CA3Q9s/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Hkcop5nypfA41fQcZdewWn https://cassyni.com/events/5nNK5LNdDrpH1ov8CA3Q9s?videoPreview=1 Characterizing microbial community viability with RNA-based high-throughput sequencingnohttps://cassyni.com/events/5nNK5LNdDrpH1ov8CA3Q9s?videoPreview=12021-11-09T19:00:00+00:00764.04Microbiome Virtual International Forum Characterization of microbial community viability is of great importance: essentially all sequence-based technologies do not differentiate living from dead microbes, whereas the functions and phenotypes of microbial communities are defined by biochemically active (“viable”) organisms. As a result, our understanding of microbial community structures and their potential transmission mechanisms remains incomplete. As a potential solution to this issue, 16S RNA-based amplicon sequencing (not rRNA gene, but the rRNA transcripts) has been proposed as a method to quantify the viable fraction of a microbial community, but its reliability has not been evaluated systematically. Here, we present our work to benchmark 16S-RNA-seq (targeting 16S rRNA transcripts and genes for parallel RNA and DNA sequencing) for viability assessment in synthetic and realistic microbial communities. In synthetic communities, we found that 16S-RNA-seq successfully reconstructed the mixtures of heat-killed Escherichia coli and Streptococcus sanguinis. We then applied this technique to natural communities (computer screens and mice, soil, and saliva) spiked with known concentrations of living and heat-killed E. coli to evaluate its performance in realistic conditions. No significant compositional differences were explained by the 16S-RNA assessment, suggesting that 16S-RNA-seq is not appropriate for viability assessment in complex communities. Results were slightly different when evaluated in environmental samples of similar origins (i.e. from Boston subway systems), samples were differentiated both by environments as well as by library type. Overall, these results show that 16S-RNA-seq has promise, but that previous literature assuming that 16S-rRNA amplicons are directly, quantitatively enriched for viable microbes is likely incorrect, as the technique does not reflect microbial viability outside of very simple, synthetic “communities.” We are currently continuing this work to develop new RNA amplicon-seq markers based on protein-encoding genes cpn60, as well as to improve viability assessment with multi-omic integration, e.g. combining amplicon-seq with functional indicators such as metatranscriptomic and metaproteomic profiles. These can circumvent some of the current limitations of 16S-RNA-seq, providing a complementary definition of viability, and directly observing activities such as virulence, pathogenicity, or antimicrobial resistance that are not captured by amplicon sequencing.https://cassyni-user-files-prod.s3.amazonaws.com/Hkcop5nypfA41fQcZdewWn https://cassyni.com/slides/outline/NaSUmCtMYna7Wcc8MjK957 https://cassyni.com/events/NaSUmCtMYna7Wcc8MjK957/abstract https://cassyni-user-files-prod.s3.amazonaws.com/ADUjpzYFWBPSGbgtoMLznr https://cassyni.com/events/NaSUmCtMYna7Wcc8MjK957?videoPreview=1 Deep genomic characterization of the gut microbiome: A novel space for biomarker discoverynohttps://cassyni.com/events/NaSUmCtMYna7Wcc8MjK957?videoPreview=12024-03-20T15:00:00+00:001184.32Microbiome Virtual International Forum No abstracthttps://cassyni-user-files-prod.s3.amazonaws.com/ADUjpzYFWBPSGbgtoMLznr https://cassyni.com/slides/outline/2Kq5kYqx9ewdz7cZYVfSd3 https://cassyni.com/events/2Kq5kYqx9ewdz7cZYVfSd3/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Vnn3uWW6ouBhs5JdFnudQi https://cassyni.com/events/2Kq5kYqx9ewdz7cZYVfSd3?videoPreview=1 Experimental Investigation of Force Transients during Gust Encountersnohttps://cassyni.com/events/2Kq5kYqx9ewdz7cZYVfSd3?videoPreview=12022-11-09T14:00:00+00:003241.04Department of Aeronautics and AstronauticsA better understanding of the gust flow is crucial to develop models capable of predicting unsteady forcing. This study aims to improve understanding of fundamental flow physics behind the unsteady force production during gust encounters. The bulk of the results that will be presented in this talk were obtained experimentally for a flat plate passing through a transverse gust created in a water towing tank and found to have a sine-squared velocity profile. The effects of 4 different parameters, namely angle of attack, gust ratio, effective angle of attack, and aspect ratio, were explored. Both 2D (PIV) and 3D (dye-flow visualization) flowfields were examined for each parameter to highlight the force transients. The accuracy and limitations of Kussner's model were evaluated by comparing the sine-squared and trapezoidal transverse gusts. A momentum flux-based normalization is introduced to scale the force transients of different transverse velocity profiles. Moreover, the effect of gust type on the unsteady forcing was examined by comparing the sine-squared transverse and vortex gusts. Image credit: [Andrew Dawes (Unsplash)](https://unsplash.com/photos/a-red-object-on-a-pole-0zfhSTsriTg).https://cassyni-user-files-prod.s3.amazonaws.com/Vnn3uWW6ouBhs5JdFnudQi https://cassyni.com/slides/outline/4o56yy5aLwi8M4686Ba5Ly https://cassyni.com/events/4o56yy5aLwi8M4686Ba5Ly/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Bx956CWzgLHxBoWrx7kgqC https://cassyni.com/events/4o56yy5aLwi8M4686Ba5Ly?videoPreview=1 Not all stool is created equal: Strain engraftment competition and functional augmentation in a multi-donor faecal microbiota transplantation trial for obesitynohttps://cassyni.com/events/4o56yy5aLwi8M4686Ba5Ly?videoPreview=12022-04-12T12:00:00+00:0059.6Microbiome Virtual International Forum Transplantation of faecal microbiota (FMT) from healthy lean donors has been shown to transiently improve insulin sensitivity and alter fat distribution in individuals with obesity and metabolic syndrome. However, the mechanisms and levels of donor strain engraftment required to elicit these effects remain poorly characterised. To address this, we performed a double-blinded randomised placebo-controlled trial for FMT in 87 adolescents with obesity. Participants were randomized to receive multi-donor FMT (capsules containing the fecal microbiota of four healthy, lean, sex-matched donors) or placebo (saline capsules). Following a bowel cleanse, participants ingested a total of 28 capsules over two consecutive days. FMT capsules and recipient stool samples collected at baseline, 6-, 12- and 26-weeks post-treatment were analysed by shotgun metagenomic sequencing allowing us to track donor strain engraftment and monitor changes in the recipient gut microbiome over time. We found that multi-donor FMT sustainably altered the structure and functional potential of the gut microbiome for up to six months. In what was effectively a microbiome competition experiment, we discovered that two donor microbiomes (one female, one male) dominated strain engraftment. These ‘super-donor’ microbiomes were characterized by high microbial diversity and a high Prevotella to Bacteroides ratio. Engrafted strains led to enterotype-level shifts in community composition and provided genes that altered the metabolic potential of the microbiome, including pathways previously shown to be important in energy balance homeostasis (e.g. NAD biosynthesis). Despite our attempts to standardize FMT dose and donors, FMT recipients varied widely in their engraftment of donor strains suggesting the host environment plays a critical role in mediating FMT receptivity. Further work is required to better understand the various host-microbe interactions that determine engraftment success to help in developing more effective and personalised microbial therapies. Link to OA paper: https://microbiomejournal.biomedcentral.com/articles/10.1186/s40168-021-01060-7https://cassyni-user-files-prod.s3.amazonaws.com/Bx956CWzgLHxBoWrx7kgqC https://cassyni.com/slides/outline/VzAYTTbE8esx1C8bKcAsV7 https://cassyni.com/events/VzAYTTbE8esx1C8bKcAsV7/abstract https://cassyni-user-files-prod.s3.amazonaws.com/KEg7Qeo6kUXFcqfQCMZcuC https://cassyni.com/events/VzAYTTbE8esx1C8bKcAsV7?videoPreview=1 The microbiome assembly: effect of environment and birthmodenohttps://cassyni.com/events/VzAYTTbE8esx1C8bKcAsV7?videoPreview=12023-03-14T11:45:00+00:001712.04Microbiome Virtual International Forum Mammals develop in utero under sterile conditions and acquire the pioneer microbial colonizers during and after birth. C-section entitles missing the exposure to maternal microbes during birth and has long lasting effects on the infant microbiome structure. Labor experience and the environment can also have effects on the assembly of the early life microbiome. Link to paper: https://www.nature.com/articles/s41598-018-33995-7https://cassyni-user-files-prod.s3.amazonaws.com/KEg7Qeo6kUXFcqfQCMZcuC https://cassyni.com/slides/outline/CCoAgDnSvp1xqdcb44Roky https://cassyni.com/events/CCoAgDnSvp1xqdcb44Roky/abstract https://cassyni-user-files-prod.s3.amazonaws.com/U838z2moDkJSBWpSK9Mdug https://cassyni.com/events/CCoAgDnSvp1xqdcb44Roky?videoPreview=1 BMI and BPH correlate with urinary microbiome diversity and lower urinary tract symptoms in mennohttps://cassyni.com/events/CCoAgDnSvp1xqdcb44Roky?videoPreview=12024-02-27T12:00:00+00:00646.04Microbiome Virtual International Forum Several studies have identified bacteria and other microbes in the bladder and lower urinary tract in the absence of infection. In women, the urinary microbiome has been associated with lower urinary tract symptoms (LUTS) such as urge urinary incontinence. However, similar studies have not been undertaken in large cohorts of men. Here we examine the urinary microbiome and its association with LUTS in a subset of 500 men aged 65 to 90 years from the Osteoporotic Fractures in Men (MrOS) study. We identified significant associations between benign prostatic hyperplasia (BPH), age, and body mass index (BMI) with several diversity metrics. Our analysis revealed complex relationships between BMI, BPH, LUTS, and alpha diversity which give insight into the intricate dynamics of the urinary microbiome. By beginning to uncover the interrelationships of BPH, BMI, LUTS, and the urinary microbiome, these results can inform future study design to better understand the heterogeneity of the male urinary microbiome.https://cassyni-user-files-prod.s3.amazonaws.com/U838z2moDkJSBWpSK9Mdug https://cassyni.com/slides/outline/P565otXszF8AWP91xAbwLR https://cassyni.com/events/P565otXszF8AWP91xAbwLR/abstract https://cassyni-user-files-prod.s3.amazonaws.com/G29qMHRSU2k3DK6BqUQjZp https://cassyni.com/events/P565otXszF8AWP91xAbwLR?videoPreview=1 Gut microbiome modulates tacrolimus pharmacokinetics through the transcriptional regulation of ABCB1nohttps://cassyni.com/events/P565otXszF8AWP91xAbwLR?videoPreview=12023-09-19T10:00:00+00:0064.24Microbiome Virtual International Forum Background. Following solid organ transplantation, tacrolimus (TAC) is an essential drug in the immunosuppressive strategy. Its use constitutes a challenge due to its narrow therapeutic index and its high inter- and intra- pharmacokinetic (PK) variability. As the contribution of the gut microbiota to drug metabolism is now emerging, it might be explored as one of the factors explaining TAC PK variability. Herein, we studied the contribution of the gut microbiota to TAC PK, using a combination of in vivo and in vitro models. Results. TAC oral administration was performed in mice. Compared to controls, mice with a lower intestinal microbial load due to antibiotics administration exhibit a 33% reduction in TAC whole blood exposure and a lower inter-individual variability. This reduction in TAC levels was strongly correlated with higher expression of the efflux transporter ABCB1 (also known as the p-glycoprotein (P-gp) or the multidrug resistance protein 1 (MDR1)) in the small intestine. Conventionalization of germ-free mice confirmed the ability of the gut microbiota to downregulate ABCB1 expression in a site-specific fashion. The functional inhibition of ABCB1 in vivo by zosuquidar formally established the implication of this efflux transporter in the modulation of TAC PK by the gut microbiota. Furthermore, we showed that polar bacterial metabolites could recapitulate the transcriptional regulation of ABCB1 by the gut microbiota, without affecting its functionality. Finally, whole transcriptome analyses pinpointed, among others, the Constitutive Androstane Receptor (CAR) as a transcription factor likely to mediate the impact of the gut microbiota on ABCB1 transcriptional regulation. Conclusions. We highlight for the first time how the modulation of ABCB1 expression by bacterial metabolites results in changes in TAC PK, affecting not only blood levels but also the inter-individual variability. More broadly, considering the high number of drugs with unexplained PK variability transported by ABCB1, our work is of clinical importance and paves the way for incorporating the gut microbiota in prediction algorithms for dosage of such drugs. Link to OA paper: http://dx.doi.org/10.1186/s40168-023-01578-yhttps://cassyni-user-files-prod.s3.amazonaws.com/G29qMHRSU2k3DK6BqUQjZp https://cassyni.com/slides/outline/HdxSJNR7AD367WtnMFc9Ly https://cassyni.com/events/HdxSJNR7AD367WtnMFc9Ly/abstract https://cassyni-user-files-prod.s3.amazonaws.com/8qSJonKgAwB6i5CkHz7exv https://cassyni.com/events/HdxSJNR7AD367WtnMFc9Ly?videoPreview=1 Understanding the Biodiversity of an Ecosystem Under Stress: Tales from Inflammatory Bowel Diseasesnohttps://cassyni.com/events/HdxSJNR7AD367WtnMFc9Ly?videoPreview=12023-11-14T13:00:00+00:002128.0Microbiome Virtual International Forum A wide variety of human diseases are associated with loss of microbial diversity in the human gut, inspiring a great interest in the diagnostic or therapeutic potential of the microbiota. However, the ecological forces that drive diversity reduction in disease states remain unclear, rendering it difficult to ascertain the role of the microbiota in disease emergence or severity. One hypothesis to explain this phenomenon is that microbial diversity is diminished simply because disease states select for microbial populations that are more fit to survive environmental stress caused by inflammation or other host factors. The purpose of this talk is to demonstrate how such microbes with 'high metabolic independence', characterized by the genomic presence of a set of key metabolic modules for the synthesis of essential nutrients dominate gut environments under stress. This paradigm depicts microbes as bystanders by default, rather than perpetrators or drivers of noncommunicable human diseases, and provides an ecological framework to explain the frequently observed reduction in microbial diversity associated with IBD and other noncommunicable human diseases and disorders.https://cassyni-user-files-prod.s3.amazonaws.com/8qSJonKgAwB6i5CkHz7exv https://cassyni.com/slides/outline/YTQZgsprKweSN8c9sJ5WD3 https://cassyni.com/events/YTQZgsprKweSN8c9sJ5WD3/abstract https://cassyni-user-files-prod.s3.amazonaws.com/54G1ff6JjU7mQgpeSc7iQe https://cassyni.com/events/YTQZgsprKweSN8c9sJ5WD3?videoPreview=1 Harmony in High Speed Combustionnohttps://cassyni.com/events/YTQZgsprKweSN8c9sJ5WD3?videoPreview=12023-11-02T11:00:00+00:003580.04Department of Aeronautics and AstronauticsProcesses in nature are sometimes characterized by disorder and other times by order.  Such is the case with the phenomena of combustion; one can compare the disorder of a crackling flame in a fireplace to the order of a candle flame in still air.  Analogs exist in high speed combustion such as might be present in rocket nozzles or high speed air-breathing jet engines.  Here, a paradigm problem in high speed combustion will be considered in which the transition from order to disorder will be studied in a controlled fashion.  The mathematical model is one that closely mimics nature, namely the compressible reactive Navier-Stokes equations for a mixture of calorically imperfect ideal gases that react via a model of detailed chemical kinetics.  The key physical mechanisms considered are reaction, advection, and diffusion. Their relative importance dictates the physical flame structures which are predicted.  One-dimenensional unsteady models of hydrogen-air combustion are examined.  The solution is mathematically verified by use of a wavelet-based method which adapts the computational grid automatically so as to meet a user-specified error tolerance.  The solution is then validated by comparing its predictions to those of similar experiments.  Importantly, both the model and the experiment reveal a fundamental frequency of about 1 MHz.   This resonance is mainly driven by reaction and advection between the lead shock and the end of the reaction zone, somewhat analogous to standing waves in organ pipes.  For higher frequency modes, the influence of physical diffusion is more important.   The model is then used to study the non-linear dynamics of oscillatory combustion, and a variety of harmonic modes are revealed as part of a transition towards chaos.  For simple kinetic models, the transition is characterized by a bifurcation process well-characterized by the Feigenbaum constant.   For detailed kinetics, a more complex transition is predicted. Image credit: [Tirza van Dijk (Unsplash)](https://unsplash.com/photos/bonfire-on-fire-pit-hbwdmqcmP6k).https://cassyni-user-files-prod.s3.amazonaws.com/54G1ff6JjU7mQgpeSc7iQe https://cassyni.com/events/TWvXE3MbwN7Qy2torpNWUu/abstract https://cassyni-user-files-prod.s3.amazonaws.com/2yjVjcTFu35yLcxodyPK3t https://cassyni.com/slides/outline/WyBXQXjQyxiqDAzaZuFmyo https://cassyni.com/events/WyBXQXjQyxiqDAzaZuFmyo/abstract https://cassyni-user-files-prod.s3.amazonaws.com/8yM4KPXmzS8pk2acKo6Bca https://cassyni.com/events/WyBXQXjQyxiqDAzaZuFmyo?videoPreview=1 Effect of Heat Flux and Exponential Viscosity Variation on the Stability of Thin Liquid Films over Cylindrical Substratesnohttps://cassyni.com/events/WyBXQXjQyxiqDAzaZuFmyo?videoPreview=12025-06-24T10:00:00+00:00600.44NODYSIn paper manufacturing technology, a Yankee cylinder—a hollow, uniformly heated cylinder, is commonly used to dry thin films of paper pulp. To develop a realistic model of this drying process, we consider the gravity-driven flow of an incompressible, Newtonian thin liquid film along the outer surface of a hollow, vertically-oriented cylindrical wall. This wall is assumed to be infinitely long and to have a small thickness. A heater embedded within the inner side of the cylinder maintains a uniform temperature across the cylindrical surface. The temperature difference between the heated wall and the surrounding liquid generates a constant heat flux, directed radially outward. Since the cylinder is hollow, some heat is lost from the inner surface of the cylindrical wall to the surrounding air filling the core. This heat loss, which was neglected in previous studies, influences the thermal gradient across the cylinder. Given that viscosity is temperature-dependent, we assume it varies exponentially with the local temperature gradient. Applying the long-wave expansion method, we derive a Benney-type nonlinear partial differential equation describing the evolution of the instantaneous film thickness. A normal-mode linear stability analysis is then conducted to determine the onset of instability, characterized by a critical Reynolds number that incorporates the effects of both viscosity variation and heat flux, including the influence of heat loss at the wall-liquid and wall-air interfaces. For the nonlinear regime, we use the Fourier Spectral Method to perform simulations based on the fully nonlinear free-surface equation. Results from the nonlinear analysis show strong agreement with findings from the corresponding linear stability analysis.https://cassyni-user-files-prod.s3.amazonaws.com/8yM4KPXmzS8pk2acKo6Bca https://cassyni.com/slides/outline/RY3su1ce9vdkpJkLxzFyzM https://cassyni.com/events/RY3su1ce9vdkpJkLxzFyzM/abstract https://cassyni-user-files-prod.s3.amazonaws.com/F5cwpnP7Wf49DU22fsKBtz https://cassyni.com/events/RY3su1ce9vdkpJkLxzFyzM?videoPreview=1 Canonical Forms of 3D Cusp-Fold Singularities and its Unfoldingnohttps://cassyni.com/events/RY3su1ce9vdkpJkLxzFyzM?videoPreview=12025-06-24T10:00:00+00:00718.28NODYSIn this paper we obtain 32 canonical forms for 3D piecewise smooth vector fields presenting the so called cusp-fold singularity. All these canonical forms are topologically distinct and collect the main topological aspects of the singularities described. Also, one-parameter bifurcations of these canonical forms are presented and the topologically equivalent piecewise smooth vector fields are obtained.https://cassyni-user-files-prod.s3.amazonaws.com/F5cwpnP7Wf49DU22fsKBtz https://cassyni.com/slides/outline/6GmK6MPB352t3ihr3gfgJ9 https://cassyni.com/events/6GmK6MPB352t3ihr3gfgJ9/abstract https://cassyni-user-files-prod.s3.amazonaws.com/8uWtkEo42S8vK7q8JeYc6A https://cassyni.com/events/6GmK6MPB352t3ihr3gfgJ9?videoPreview=1 Optimization and evaluation of lower limb exoskeleton based on human-exo coupling dynamicsnohttps://cassyni.com/events/6GmK6MPB352t3ihr3gfgJ9?videoPreview=12025-06-24T11:00:00+00:00770.8NODYSThe rapid advancement of lower limb exoskeleton technology has created new opportunities to enhance human locomotion and reduce operational fatigue. In our study, the in-depth investigation of human-exoskeleton coupling dynamics has been conducted and exoskeleton performance by evaluating assistive efficiency has been optimized. First, we propose a linear human-exoskeleton coupling model that integrates electromyography (EMG) features and human physiological parameters to predict coupling parameters using a CNN-LSTM neural network. On this basis, we refine the coupling model to a nonlinear framework, analyzing the effects of coupling position, looseness, and other influencing factors on the coupling parameters. Additionally, we propose a regression model for predictive analysis. To further explore human-exoskeleton interaction, we extract a dynamic physical model of coupling forces using a sparse regression algorithm. Additionally, we propose a mechanics-based ground reaction force calculation method and establish a human-exoskeleton coupling dynamic model for walking gait. The inertia parameters of both the exoskeleton and human body are experimentally identified to enhance model accuracy. Finally, to maximize the assistive effect of the lower limb exoskeleton, we introduce an optimization framework based on human energy efficiency principles. A set of comprehensive evaluation metrics, incorporating both joint and muscle dynamics, is established as a reference for exoskeleton performance evaluation.https://cassyni-user-files-prod.s3.amazonaws.com/8uWtkEo42S8vK7q8JeYc6A https://cassyni.com/slides/outline/8k1LKmcoEMoNQfBQbNaK25 https://cassyni.com/events/8k1LKmcoEMoNQfBQbNaK25/abstract https://cassyni-user-files-prod.s3.amazonaws.com/AdnWQdZPZY5Jqo8F18aBGz https://cassyni.com/events/8k1LKmcoEMoNQfBQbNaK25?videoPreview=1 Nonlinear control of a space robot for fast tracking pose trajectoriesnohttps://cassyni.com/events/8k1LKmcoEMoNQfBQbNaK25?videoPreview=12025-06-24T12:00:00+00:001752.64NODYSFuture space missions are calling for ultra-large space structures assembled on orbit by space robots. It is challenging to control flying space robots in such an assembly due to the nonlinear dynamic coupling between robots and their floating base. This lecture presents how to use Lie group structure of a robot configuration and to formulate the system momentum evolution equations. Then, it gives the design of manifold model predictive controller to solve a three-dimensional pose trajectory tracking problem. Furthermore, it presents the performance of the above controller in numerical simulations, emphasizing the momentum shaping and prediction horizon selection. Finally, the lecture demonstrates the trajectory tracking and object capturing experiments in a three-dimensional space via an air-bearing space robot simulator.https://cassyni-user-files-prod.s3.amazonaws.com/AdnWQdZPZY5Jqo8F18aBGz https://cassyni.com/slides/outline/J8MSKPReyRFh9RgWCnERVF https://cassyni.com/events/J8MSKPReyRFh9RgWCnERVF/abstract https://cassyni-user-files-prod.s3.amazonaws.com/CjYKrY4NRjRiwzdUAfbR6E https://cassyni.com/events/J8MSKPReyRFh9RgWCnERVF?videoPreview=1 Nonlinear Control Strategies in a Co-Simulation Framework for Hybrid Regional Aircraft Design Verificationnohttps://cassyni.com/events/J8MSKPReyRFh9RgWCnERVF?videoPreview=12025-07-09T16:00:00+00:00794.84NODYSThe nonlinear flight dynamic model of a hybrid regional aircraft is being developed in Simulink for integration into the Open Digital Platform of the European project ODE4HERA. The project aims to accelerate the development of hybrid regional architectures, which are far more complex systems than the in-service airplanes. The scope of this work is to develop the pilot behavior model in a typical flight mission. This is well captured with the Total Energy Control System technique, which simultaneously acts on throttle and elevator controls. The application case aims to verify the integration of on-board systems specifically designed for hybrid electric aircraft. In detail, the flight mechanics model is integrated with the hybrid propulsion system, electric distribution, and power sources. From this perspective, the main role of flight simulation is to demonstrate whether the proposed architecture can cover a typical mission profile expected for regional transport airplanes.https://cassyni-user-files-prod.s3.amazonaws.com/CjYKrY4NRjRiwzdUAfbR6E https://cassyni.com/slides/outline/GeQdBLV5f3b2ihhPMMZ1cH https://cassyni.com/events/GeQdBLV5f3b2ihhPMMZ1cH/abstract https://cassyni-user-files-prod.s3.amazonaws.com/RJXnV1emntizNJ2mNzb4fQ https://cassyni.com/events/GeQdBLV5f3b2ihhPMMZ1cH?videoPreview=1 Searching for SQuIDs: Stable Quasi-Isodynamic Designs as Fusion Reactor Candidatesnohttps://cassyni.com/events/GeQdBLV5f3b2ihhPMMZ1cH?videoPreview=12025-02-27T16:00:00+00:002533.36Journal of Plasma PhysicsQuasi-isodynamic (QI) stellarators are uniquely attractive fusion reactor candidates due to their good fast ion confinement and small toroidal currents, ensuring disruption-free operhttps://cassyni-user-files-prod.s3.amazonaws.com/RJXnV1emntizNJ2mNzb4fQ https://cassyni.com/slides/outline/9EgZV5nD5BHWxfWUoBwPAD https://cassyni.com/events/9EgZV5nD5BHWxfWUoBwPAD/abstract https://cassyni-user-files-prod.s3.amazonaws.com/U26cEmiACumaEwv76YygwQ https://cassyni.com/events/9EgZV5nD5BHWxfWUoBwPAD?videoPreview=1 Progress in Laboratory 3D Torisional Magnetic Reconnectionnohttps://cassyni.com/events/9EgZV5nD5BHWxfWUoBwPAD?videoPreview=12024-09-05T15:00:00+00:002537.64Journal of Plasma PhysicsMagnetic reconnection is a well known phenomenon in astrophysical plasmas and occurs in the solar corona and Earth's magnetotail. The most commonly studied type of reconnection in the lab is the 2D X-type. However, astrophysical plasmas have complex 3D magnetic structures which result in 3D reconnection events. This work is focused on a particular type of 3D reconnection called the torsional magnetic reconnection (TMR). TMR is one potential mechanism for coronal mass ejections and has been investigated theoretically and computationally since the early 2000s. Besides astrophysical cases, 3D reconnction also has potential application to space propulsion and inertial fusion, if the phenomenon can be produced in the lab. This talk presents the background on TMR and the current efforts to produce laboratory TMR between the University of Alabama in Huntsville and SpaceWave LLC under funding from the US Department of Energy.https://cassyni-user-files-prod.s3.amazonaws.com/U26cEmiACumaEwv76YygwQ https://cassyni.com/slides/outline/BhvaiW1qGU41Kbz3Lsr1t9 https://cassyni.com/events/BhvaiW1qGU41Kbz3Lsr1t9/abstract https://cassyni-user-files-prod.s3.amazonaws.com/NaxxjFbPNsg8SKa6Apr4hk https://cassyni.com/events/BhvaiW1qGU41Kbz3Lsr1t9?videoPreview=1 Separatrix parameters and core performances across WEST L-mode databasenohttps://cassyni.com/events/BhvaiW1qGU41Kbz3Lsr1t9?videoPreview=12023-06-08T15:00:00+00:002015.28Journal of Plasma PhysicsWEST database analysis shows a correlation of the recycled neutral source around the separatrix with core performances. This observation questions the causality chain between particle source and turbulent transport up to the core in L-mode, high recycling plasmas, an unavoidable phase of all scenarios. The best core performances correlate with the lowest values of the density at the separatrix n_sep, similarly to AUG and JET in H-mode [G. Verdoolaege et al 2021 Nucl. Fusion 61 076006]. Reflectometry in the midplane provides n_sep, while T_sep is inferred by the ‘two-point model’ using Langmuir Probe data on divertor targets. Lower separatrix resistivity does not correlate with better core performances, unlike H-mode observations [T. Eich et al 2020 Nucl. Fusion 60 056016]. As expected in presence of an efficient neutral source due to recycling fluxes, n_sep correlates with the D recycled particle flux at the divertor measured by visible spectroscopy. Coherently, at a given controlled central line integrated density n ̅, lower n_sep correlates with larger density gradient around the separatrix as well as larger global density peaking, n ̅/〈n〉 measured by interferometry. The later correlates as well with lower collisionality in the core, similarly to JET and AUG H-modes [C. Angioni et al 2007 Nucl. Fusion 47 1326]. The correlations reported allow phrasing the subsequent causality question: What is the interplay chain between low neutral recycling at the divertor plates, low density at the separatrix, high density peaking at the separatrix, high global density peaking, higher central temperature, better core energy confinement quality? The causality chain understanding is essential to prepare ITER operation and design DEMO scenarios where the ratio of the divertor leg to the ionization length will be larger and where the pumping efficiency with respect to the vacuum vessel volume will be weaker with respect to actual operating tokamaks.https://cassyni-user-files-prod.s3.amazonaws.com/NaxxjFbPNsg8SKa6Apr4hk https://cassyni.com/events/Q4AJzDhqeGpbMkvFboMBeu/abstract https://cassyni-user-files-prod.s3.amazonaws.com/8uyyeScaq7iVR2HtbqUks8 https://cassyni.com/slides/outline/Jd2fUhb4pEjWxtg1ztMPfT https://cassyni.com/events/Jd2fUhb4pEjWxtg1ztMPfT/abstract https://cassyni-user-files-prod.s3.amazonaws.com/HeUvGR88zJ973DrkAM94yc https://cassyni.com/events/Jd2fUhb4pEjWxtg1ztMPfT?videoPreview=1 Cross-scale interactions between ion and electron-scale turbulence in magnetized plasmasnohttps://cassyni.com/events/Jd2fUhb4pEjWxtg1ztMPfT?videoPreview=12022-05-26T15:00:00+00:003850.12Journal of Plasma PhysicsRecent gyrokinetic simulations have revealed the existence of cross-scale interactions between disparete turbulence at ion and electron gyroradius scales. I would like to start my talk by reviewing recent studies of multi-scale gyrokinetic simulations and discussing problems to be solved in future. For addressing one of these issues, we examine the extrapolation of cross-scale interactions toward high electron temperature burning plasmas, and demonstrate a possibility of reduction of turbulent transport by cross-scale interactions. In the latter part of this talk, I also would like to discuss the methodology for extracting and modeling cross-scale interactions between disparate-scale turbulence. To this end, we have developed a statistical analysis technique based on Mori-Zwanzig projection operator method, which decomposes time evolution of variable of interests into correlated/uncorrelated terms with regard to the explanatory variables. We discuss validity/applicability of the method to multi-scale turbulence problem based on the results of application example to simple plasma turbulence problem.https://cassyni-user-files-prod.s3.amazonaws.com/HeUvGR88zJ973DrkAM94yc https://cassyni.com/events/K7gGXPEbFhHZxfCubKeBvm/abstract https://cassyni-user-files-prod.s3.amazonaws.com/L7iwVqMmBaue5P6Xd8wRyp https://cassyni.com/events/VVHxVjpcUJuzVAW3cRb5cH/abstract https://cassyni-user-files-prod.s3.amazonaws.com/EoSqzZV82wmxtSFsBcsaYv https://cassyni.com/events/S2kjAxHwQ73MTUCUxmD85T/abstract https://cassyni.com/events/UVzkQNXZbPoqpQg3WT7koP/abstract https://cassyni.com/events/5HXMEF7txsn6KUkCgeHnBw/abstract https://cassyni-user-files-prod.s3.amazonaws.com/9f8bqmxK1VnWYFi7crxu8r https://cassyni.com/slides/outline/HdEFL124gpxCK6nLvVCevq https://cassyni.com/events/HdEFL124gpxCK6nLvVCevq/abstract https://cassyni-user-files-prod.s3.amazonaws.com/B5cd54a52RJeDPGMQw7782 https://cassyni.com/events/HdEFL124gpxCK6nLvVCevq?videoPreview=1 Oncology: Natural Killer Cell Therapynohttps://cassyni.com/events/HdEFL124gpxCK6nLvVCevq?videoPreview=12022-11-30T16:00:00+00:007558.36Research Seminars by Springer NatureThis webinar focuses on Natural Killer Cell Therapy. Our panellists discuss developments in this exciting research field and their global perspectives. Editorial Board Member of Cancer Immunology, Immunotherapy, Prof Torsten Tonn, is chairing the webinar. The journal invites you to read related content in the collection on [Natural Killer Cell Therapy](https://link.springer.com/collections/ihagbgjaeg) and welcomes future submissions. If you would be interested in contributing to the ongoing collection, we would be delighted to speak with you about any potential ideas for submissions and if you message us when you submit (via vicky.brewis@springernature.com), we will highlight your submission to the Editor in Chief as part of the collection.https://cassyni-user-files-prod.s3.amazonaws.com/B5cd54a52RJeDPGMQw7782 https://cassyni.com/slides/outline/BDZCp7XArcmB7hEnerfEsw https://cassyni.com/events/BDZCp7XArcmB7hEnerfEsw/abstract https://cassyni-user-files-prod.s3.amazonaws.com/H7U7R1qxyDNWZ6kU2KWy1x https://cassyni.com/events/BDZCp7XArcmB7hEnerfEsw?videoPreview=1 Taphonomy of late Miocene balaenopterids from the Stirone River, Emilia Romagna (Northern Italy)nohttps://cassyni.com/events/BDZCp7XArcmB7hEnerfEsw?videoPreview=12025-03-26T09:00:00+00:001408.48Frontiers in Earth ScienceAfter death, carcasses of large whales may have different destinies. Sometimes they fall on the sea floor where may be quickly buried by sediments; in these cases, in the presence of particular conditions, the skeletons may fossilize without disturbance maintaining the natural articulations of the bones. In other cases, the carcasses fall on the sea floor and stay there for long time. During this time interval, specialized whale-fall communities and opportunistic species dismember and exploit the carcass. In the case in which the disturbed and exploited carcass is buried, the natural articulations, and compactness and integrity of the bones are not maintained. The ecology of the whale-fall communities represents an interesting subject to understand how the enormous amount of energy stored in whale bodies is released to the environment. While a number of whale-fall communities is now described in the literature from extant marine ecosystems, only a few information is available from the fossil record and almost all what we know about the extinct whale species is from Pliocene. Here we describe the taphonomy of three balaenopterid whales from the late Miocene of the Stirone river including the holotype of Plesiobalaenoptera quarantellii, an undescribed balaenopterid and a single periotic bone from a third individual. The associated fauna suggests that these cetaceans were buried once deposited and disturbed on a sea floor of a shallow sea (about 30-50 m in depth). Several traces on the bones show the impact of whale-fall communities that intensely exploited the carcasses, dismembered most of them and partially damaged and destroyed some of the bones. In one case, the whale-fall community seems similar to those observed in extant ecosystems but, differing from the modern ones, it was active on a shallow sea floor. We provide a new stratigraphic analysis of the site for determining the age of the specimens with the highest precision; we also provide analysis of the associated fauna including molluscs, sea urchins, microfossils and fishes. The traces on the bones are then described and illustrated with macro photography in order to provide a detailed analysis of c. 10 Ma whale-fall communities providing evidence about whale-fall community evolution in the Mediterranean basin. https://cassyni-user-files-prod.s3.amazonaws.com/H7U7R1qxyDNWZ6kU2KWy1x https://cassyni.com/slides/outline/4oDDZ7f1MkLm5k9yUrscjF https://cassyni.com/events/4oDDZ7f1MkLm5k9yUrscjF/abstract https://cassyni-user-files-prod.s3.amazonaws.com/YUdu4BrEJPDg3J99qJLiSi https://cassyni.com/events/4oDDZ7f1MkLm5k9yUrscjF?videoPreview=1 Are We Staying True to the Vision of Open Science – or have we strayed?nohttps://cassyni.com/events/4oDDZ7f1MkLm5k9yUrscjF?videoPreview=12025-01-15T09:00:00+00:003187.52Academic Publishing in EuropeAPE 25 Question 1 : So if we wiped the slate completely clean, what would your vision of a world in which open science is operating optimally look like? A world in which open science would work optimally would be a world where priorities are set clearly. The centre of such a world is science (taken here in its widest sense, i.e. as knowledge) and the workings of this open science would be fully, thoroughly, consciously (and intelligently) organized to provide the best possible conditions for the production of reliable and usable knowledge. What do I mean by reliable and useful knowledge? Knowledge, however paradoxical this may sound to some, is never certain. Its main quality in fact is to be always open to criticism, emendations, corrections, clarifications and it can even be totally upended in some circumstances generally referred to as “revolution” in the sciences of nature (cf. Thomas Kuhn), or epistemological ruptures or breaks in other contexts, such as the human sciences (but not exclusively, cf. Bachelard, Canguilhem, Foucault). Unlike religious belief and its reliance on some form of transcendental source that, curiously, puts it in the ambit of certainty – another paradox -, knowledge is totally contingent, human based. Knowledge is the product of endless discussions, debates, criticisms following painstaking observations and experiments conducted systematically and methodically. It stands to reason that, given the contingent nature of knowledge, its quality depends on the depth and breadth to which discussions and debates are being conducted. The longer an issue is discussed, and the larger the number of researchers involved, the better knowledge will be. How do I define the quality of knowledge? Simply by its ability to encompass an ever greater set of variables, and by its capacity to make predictions with a better degree of accuracy. Think meteorology. Having posited the central position of knowledge, and its evolutionary status as I just did, it becomes clear that open science aims at preserving the centrality of knowledge, and aims also at optimizing the “Great Conversation” – a term which I have already used in the past, and the meaning of which is summarized in the previous paragraph. Anything that threatens the centrality of the quest for knowledge, and anything that limits the possibilities of scrutiny of existing knowledge works against the “Great Conversation”. Furthermore, anything that limits the possibility of contributions by qualified individuals also works against the “Great Conversation”. Now, the “Great Conversation” is a phrase that covers all the elements of scholarly communication and publication. From the discussions at the bench or in a seminar at the local and individual level to the exchanges of articles and other published interventions that reflect the existence of a debate about some issue, all these exchanges are part of the “Great Conversation”. The whole starting point of the Open Access movement was anchored in that perception and the Budapest Initiative, however imperfectly, was responding to a perspective where knowledge could be produced, circulated, discussed, modified, etc. with as few barriers as possible. Right off the start, participants like myself at the Budapest meeting of 2001 were keenly aware that material elements constrained this vision: communicating and publishing both cost something, and thinking about how to support mechanisms of communication and publishing became, of course, an immediate topic of concern. However, the necessity to think “realistically” did not mean replacing the centrality of knowledge by economic or financial issues. On the contrary, it meant thinking about financial or economic terms as supporting elements of the primary task at hand: producing knowledge. In other words, discussions about financing, business plans, etc. should have been framed with knowledge at the centre, and financial issues as supporting elements. Also, financial issues are not necessarily expressed in terms of business plans. Alas, the history of the Open Access movement has been marked by what should not have been done: rather than keeping the central position of knowledge in place, discussions quickly drifted to business plans. Even before Budapest, the likes of Vitek Tracz and Jan Velterop, with Biomed Central, were deflecting the discussions around the validity and advantages of a business model that would provide a degree of “business realism” to the Open Access movement: the APC model. The Open Access movement got caught in this diversion and the emergence of PloS in 2003 only reinforced the primacy of the business plan issue over knowledge issues. In effect, the Open Access movement had fallen victim to Lampedusa’ quip in his novel, “The Leopard”: If you want to keep everything in place, you have to change everything. Changing everything in this case meant a form of Open Access that kept the existing financial structure in place. What was the nature of the “everything in place”? Responding to this question would require diving into the history of scholarly publishing after WW II. This is not the place, and a sketch will have to do. The period after 1950 saw the incursions of commercial scientific publishers as more than providers of services to scientific communities. They started to create (and, therefore, own) large numbers of new journals that scientific associations were not creating and managed to make them economically viable thanks to the unique conditions of scientific research in the context of the Cold War. Then, thanks to Garfield’s Science Citation Index, and his Impact Factor, journals became the anchor of a market structure tightly defined by new competition rules based on Garfield’s indicator. Digitization in the 1990’s contributed to tightening this market structure further. From that point on, all the forms of competition at work within research – forms of competition which, initially, rested on establishing a priority regarding a specific question – were transformed into competition to publish in the journals deemed most prestigious, visible, authoritative, or whatever – no one really knows what the impact factor points to. This mode of competition, while placing the entity “journal” at the heart of knowledge production (instead of knowledge), extended from individuals to laboratories, institutions and even whole countries. Rankings became the universal obsession. Meanwhile, many of society journals had become the property of a few multinational entities such as Elsevier, Springer, Wiley, etc. The “changing everything” of Lampedusa was to make sure that the central position of journals would remain in place. The consequences of this deep transformation in the modalities of the “Great Conversation” are numerous and far-reaching. This is not the place to delve on them, given the constraints of the exercise. However, the post-WW II transformations have entangled business issues and the production of knowledge; they have largely contributed to placing the research communities on the sidelines of their communication mechanisms (including by dividing them between their elites sitting on editorial boards, and the rest judged by the same elites, often in opaque fashion). The APC model of Open Access, while apparently resolving the issue of reading access, has created new kinds of problems for poorer authors. And so on... To come back to the question raised here, the model of Open Science we need, therefore, to be freed from business constraints and profit motives. It must not discriminate against poor readers or poor authors. In this context, the Open Access “Diamond” model is the one to follow. This model does not oppose financial barriers to authors or readers. But the “Diamond” model implicitly retains the journal as its organizing principle and the transformation of scholarly journals into a form of merchandise tightly managed by a competitive market based on impact factors is the central problem. In other words, the “Diamond model” will be effective only if it manages to transform journals anew, or dispense with them altogether. Should the latter hypothesis look unrealistic, it is sufficient to point out that in a world of digital platforms, the role of journals becomes a central question and platforms become the dominant players. Here, two possible scenarios appear: •The journal remains in place, but transformed once again: now anchored in definite scientific communities, it becomes their mouthpieces (as it often used to be in the 19th century) to exchange with other, similar, communities. In this role, journals do not need to own their articles; instead,they should provide a trusted source of provenance. A Creative Commons license would also allow other, similar, community-based journals, to reproduce the articles that could be of interest to their communities. Moreover, journals would also find themselves decoupled from the value of published works: they would not intervene as venues of prestige, visibility, authority. The existence of journals could also be justified as rough sign posts for researchers navigating knowledge databases, but better navigating tools can be designed at the level of platforms, especially interconnected platforms. Finally, such journals could also act as a transitional stage in an increasingly digital word. •The journal disappears, and only the platform remains. On a platform, various algorithms can be used to aggregate research results – articles, data, software, letters, debates – in one manner or another, including in response to the needs of communities. On a platform, the goal is not to hold and preserve a version of record, but rather a “record of versions” (B. Kramer): a record of versions would track the evolution of the “Great Conversation” surrounding a particular point of knowledge (think about the page history on Wikipedia. On a platform, the syncopated nature of publishing as inherited from print could finally be replaced by a process where conversation and temporarily stabilized research results converge. The pace of publishing would better approximate the pace of scholarly communication. Researchers would navigate this new publishing landscape thanks to platform-based algorithms where the central position of knowledge would be restored. What about the financing of such a system? We can indeed come back to this old second-order issue. Now that the central place of knowledge has been secured, it is much easier to discuss this question: by coming in second, solutions will naturally be framed in terms of service to the central objective: knowledge. First of all, we should accept that publishing is an integral part of the research cycle, and not a special, separate phase taking place outside that cycle. This thesis is sometimes contested in publishing circles and is even supported by some librarians, but the NSF in the USA gives us a crucial precedent to move forward: when the issue of page charges arose in the 1950s, the NSF accepted that such charges should be paid out of research grants because research that was not published was not complete. In other words, research financing could be applied to research publishing costs. Once the unity of the research cycle is fully admitted, two questions emerge: who does what? Who pays for what? The answer to the first question is quite simple if it is agreed that researchers need publishing functions rather than publishers. These functions include registration, certification, preservation and dissemination, and there is no reason why a single actor should take on all these functions; on the contrary, registration is probably best done on site by the local library of the researcher. Certification is the task of other researchers who can ascertain the value and validity of a piece of work, not of publishers. And nothing other than a legacy of print says that “publishers” need to organize certification. Then librarians preserve: they have been preserving all over the world for centuries. As for dissemination, Internet has revolutionized that function. In the Internet, good connectivity and protocols are the key to efficient and universal dissemination. Now, this reasoning does not necessarily exclude firms or enterprises with relevant skills and know how. However, rather than collecting a rent from a competitive system that artificially intensifies the production of journals and of articles, such commercial entities would simply offer services to the scholarly communities and their infrastructures. However, these service, while helping the research process, would not become entangled with evaluation variables. As a counter example, imagine a scientific world where everyone would need to use test tubes, and imagine further that the evaluation of the research being produced depended on the brand of test tubes used... In conclusion to the first question, the most important objective is to disentangle the knowledge effort of the research communities from commercial objectives such as those pursued by a few multinational companies. Disentangling journals from scholarly value would also help a number of large scientific societies to distance their attempts at generating surpluses from their support of good knowledge. The second question can also find a good solution. If publishing is an integral part of research, the financing of scientific publishing (and communication) is done as part of the financing of research in general. Furthermore, the cost of publishing compared to the cost of research is very, very small (1 to 2%). This means that financing scientific and scholarly research is not related to finding a good business model, but rather is related to good governance and funding policies. But this is exactly how public money is spent. This is also how funding from charities is allocated. As for research funded by for-profit companies, it tends to lean in the direction of development rather than research, and it is often patented or kept secret; only a small fraction is published (e.g. in the pharmaceutical industry). Question 2: What do you see as being the role of academic institutions and the researchers themselves in that future open science world? Obviously, if knowledge is to be central in the “ideal” world, academic institutions, research institutions in general, and researchers must also play a central role. However, competition as defined by impact factor, venues, and competition of publishers through their journals works against the “Great Conversation”. Research institutions and researchers have fallen victim to a “divide and conquer” strategy where they have collectively devolved their evaluation of knowledge quality to publishing institutions. It has come to the point that, nowadays, journals grant prestige to the members of their editorial boards, rather than the reverse. As a first step, such institutions and researchers should rein in their competitive stance and focus on establishing priorities in discoveries rather than securing high visibility through the use of competitive venues. At the same time, they should give much greater emphasis to cooperation and networking with a very specific goal in mind: use the internetworking of research institutions to repatriate evaluation tasks in their midst. If research institutions begin to certify that whatever comes from their midst is worthy of being introduced in the scholarly world – a slightly more disciplined preprint world in effect – then the same networking structure could also give rise to evaluative functions that would be under the sole control of the research communities. A precedent exists to move in that direction: doctoral theses are evaluated by committees that include both internal and external readers. Take the Ph. D. jury as a model, but make the external readers the majority. Then publish the reports when the thesis is accepted and this is the record of the first version. Question 3 - What kinds of policies and business models would support each of your visions of open science? I believe that I responded to this question in the course of my first answer. Question 4 - What are the unintended consequences of the open science vision? The answer to this question will depend on the nature of the vision itself. Furthermore, if I design a vision of open science, I will work as hard as I can to avoid unintended consequences. This questions reads as if everybody agreed on a clear and fixed vision of open science (in contradiction with the plural encountered in the previous question). Is the goal here to design a possible critique of open science? The rel issue is: “What are some of the questions that may remain open in the deployment of this or that form of open science?”. For example, what are the governance issues that could arise from a given open data policy? Question 5 - I think we’re great at introspection in our community, but I’d like to ask the panel have you considered whether we could learn anything from other fields or industries that would help to support what we’re describing here as open science? Is there a role, for example, for crowd sourcing of information or for decentralized science models? And what would we need to do differently to enable such changes to be made? This is a very puzzling question. What is “our community”? I thought we were asked to deal with “open science” and express a vision of it, but doing so does not imply belonging to a single, common, community made up of publishers, librarians, administrators of research, researchers, administrators of research funding, research policy designers and implementers, etc. Etc. As for “crowdsourcing of information” and “decentralised science models”, it is even more puzzling. Isn’t scientific research inherently a form of crowd sourcing – the crowd here being made up of hundreds of thousands of researchers –, and isn’t science inherently decentralised? I simply do not understand this question. Question 6 - how do we get from where we are now to the future vision end point? I believe that my answer is already stated in question 2. Let me restate it in point form: Limit competition to priority of discoveries; Institutions and individuals privilege cooperation; Institutions and individuals work toward recovering full control of research evaluation by researchers and research communities; Institutions network their platforms in a variety of ways to stimulate connectivity, dissemination, collaboration, discovery, etc. Institutions use network structures applied to platforms to design credible evaluation processes that are not entangled with commercial aims. The end result: an Internet of minds providing the best environment for the production of reliable knowledge.https://cassyni-user-files-prod.s3.amazonaws.com/YUdu4BrEJPDg3J99qJLiSi https://cassyni.com/slides/outline/PZLyFkxznei68zGMRbFcGV https://cassyni.com/events/PZLyFkxznei68zGMRbFcGV/abstract https://cassyni-user-files-prod.s3.amazonaws.com/CzpfxKviThT5fKiv33e74r https://cassyni.com/slides/outline/FANwhPzr8b9WbPYU1mui2Z https://cassyni.com/events/FANwhPzr8b9WbPYU1mui2Z/abstract https://cassyni-user-files-prod.s3.amazonaws.com/D9hAoiF8mc242tMgEbgfhY https://cassyni.com/events/FANwhPzr8b9WbPYU1mui2Z?videoPreview=1 Exploring Potential Energy Surfaces: Development of a Tool Kit in Programming Language Julianohttps://cassyni.com/events/FANwhPzr8b9WbPYU1mui2Z?videoPreview=12022-09-22T00:15:00+00:003554.36The MacDiarmid Institute for Advanced Materials and NanotechnologyWe are interested in investigating the thermodynamic behaviour, in particular melting, of nano-clusters and bulk materials by computer simulations. As basic ingredients the knowledge of the complex potential energy surfaces (PES) for these systems is needed. During Monte Carlo simulations the PES are explored allowing us to extract the thermodynamic properties of interest like the internal energy or heat capacity. Systems explored at present include neon in strong magnetic fields, small gallium and copper/brass clusters. The PES of these systems are computed using a dimer expansion of the energy, density-functional calculations and atomistic machine-learning techniques, respectively. Further, we are interested in understanding the PES better to get insight into the melting mechanisms - here cluster analysis tools and basin-hopping algorithms are explored. The diversity of the applications means that we have to be able to deal with different potential energy models, boundary conditions and statistical ensembles in our Monte Carlo implementation. Our goal is to write a comprehensive computer program that allows for straight-forward extension to new systems and for easy method development. For this reason we decided to switch from a Fortran implementation to the relatively modern programming language Julia. In particular, the intricate type system and multiple dispatch are helpful in achieving the goal of a single, but flexible code while maintaining the possibility to write fast code due to just-in-time compilation. https://cassyni-user-files-prod.s3.amazonaws.com/D9hAoiF8mc242tMgEbgfhY https://cassyni.com/slides/outline/N534dXKuEb1PtjWB8rngUm https://cassyni.com/events/N534dXKuEb1PtjWB8rngUm/abstract https://cassyni-user-files-prod.s3.amazonaws.com/3yxpgocwDXPJPioL9G8Jo8 https://cassyni.com/events/N534dXKuEb1PtjWB8rngUm?videoPreview=1 Surface acoustic waves for particle manipulation – a holistic experimental approachnohttps://cassyni.com/events/N534dXKuEb1PtjWB8rngUm?videoPreview=12022-06-07T14:00:00+00:002419.16Experiments in FluidsAcoustic fields can be used in microfluidic devices to manipulate particles for example for the fractionation of particle suspensions or the transport and alignment of cells in biological assays. Using so called interdigital transducers on piezo-electric substrates surface acoustic waves (SAW) can be excited by applying high frequency electric signals. The superposition of different SAW can produce complex acoustic fields and pressure distributions in the bulk volume of a microchannel. In principle two forces act on the particles. The scattering of the acoustic waves on suspended particles results in the acoustic radiation force that influences their motion. Due to viscous damping of radiated waves within a fluid, a superimposed fluid flow is generated due to the acoustic streaming effect. This flow will also act on the particles by drag forces. As the boundary conditions and the physical phenomena for such systems are unknown or at least associated with a high degree of uncertainties, experimental approaches play a key role for the characterization of SAW-based microfluidics. In the current presentation astigmatism particle tracking will be introduced for 3D3C velocity measurements in conjunction with lifetime imaging to simultaneously measure the temperature in SAW devices. The data will be complemented by laser vibrometer measurements of the wave field to shed more light on the complex physics.https://cassyni-user-files-prod.s3.amazonaws.com/3yxpgocwDXPJPioL9G8Jo8 https://cassyni.com/slides/outline/H8Z2Agrer1UNVdnq8P5gkd https://cassyni.com/events/H8Z2Agrer1UNVdnq8P5gkd/abstract https://cassyni-user-files-prod.s3.amazonaws.com/E9SGKH8iLbzqifPdBnHfpJ https://cassyni.com/events/H8Z2Agrer1UNVdnq8P5gkd?videoPreview=1 Flow transition of low Reynolds number flows past a plunging airfoilnohttps://cassyni.com/events/H8Z2Agrer1UNVdnq8P5gkd?videoPreview=12022-09-14T11:00:00+00:001309.8NEKTAR++The two-dimensional to three-dimensional transition of a flow past a plunging NACA 0012 airfoil at Reynolds numbers from Re=400 to 10 000 and an angle of attack of 15 degrees was investigated using global linear stability analysis and spanwise-homogeneous direct numerical simulation (DNS). Below a Strouhal number of 0.5, the transition Reynolds number is higher than the static airfoil which indicates the plunging motion stabilises the two-dimensional baseflow. For higher frequencies, an period-doubling mode first becomes unstable, which has a peak Floquet multiplier around a spanwise wavelength of 2c. This unstable mode also dominates in three-dimensional direct numerical simulations (DNS). Finally, a short-wave mode becomes unstable at St_c=0.95, which generates more small-scale vorticies in the DNS result.https://cassyni-user-files-prod.s3.amazonaws.com/E9SGKH8iLbzqifPdBnHfpJ https://cassyni.com/slides/outline/Xx19ZCGQ1k5ikFWCeRZ3ch https://cassyni.com/events/Xx19ZCGQ1k5ikFWCeRZ3ch/abstract https://cassyni-user-files-prod.s3.amazonaws.com/7Tm5tZn6huw9oGbVhtPJtE https://cassyni.com/events/Xx19ZCGQ1k5ikFWCeRZ3ch?videoPreview=1 How to develop a bioelectronic spinal cord implantnohttps://cassyni.com/events/Xx19ZCGQ1k5ikFWCeRZ3ch?videoPreview=12022-10-18T03:00:00+00:003086.6The Auckland Bioengineering InstituteThe development of an bioelectronic neural implant requires translational efforts combining knowledge from various research fields. In this talk you will get an insight into the development and fabrication of a subdural spinal cord implant optimized to generate sustained electric fields from the viewpoint of an engineer. We used finite element models to optimize electrode position and to quantify the generated electric field and tested stimulation capabilities in vitro of the super capacitive iridium oxide electrodes. If you ever wondered how 3 um features can be structured on 8 um thin flexible polymer films or how electric current is generated in tissue, then come along to this talk.https://cassyni-user-files-prod.s3.amazonaws.com/7Tm5tZn6huw9oGbVhtPJtE https://cassyni.com/events/5me86xyakUjPDPogmPdujj/abstract https://cassyni-user-files-prod.s3.amazonaws.com/CNsnJwjqA8ycbNd96ZrYx6 https://cassyni.com/slides/outline/2K6tnBSugGrkBhW87jFxCu https://cassyni.com/events/2K6tnBSugGrkBhW87jFxCu/abstract https://cassyni-user-files-prod.s3.amazonaws.com/TPr3zpkrD8Uy5us3VjKjUi https://cassyni.com/events/2K6tnBSugGrkBhW87jFxCu?videoPreview=1 Prediction of Drag for Rough Wall Boundary Layer Flowsnohttps://cassyni.com/events/2K6tnBSugGrkBhW87jFxCu?videoPreview=12021-12-03T16:00:00+00:002976.92Journal of Fluid MechanicsSignificant progress has been made towards the understanding of rough-wall boundary layers and the subsequent drag penalty. Continued progress is promising since a larger range of parameter space can now be investigated experimentally and numerically. Recent advances in rapid prototyping techniques enables the generation of systematic variations of roughness scales and computationally efficient simulations with creative surface mapping techniques allows for experiments and computations to investigate similar complex roughness. While a universal drag prediction correlation is still elusive and may not be possible, predictive correlations for classes of surface roughness pertinent to engineering applications seem achievable. Three surface parameters based solely on surface statistics are showing promise in predictive correlations for a range of studies. These include a measure of surface elevation a slope parameter and the skewness of the surface elevation probability density function. Other candidate parameters that may be useful in a predictive correlation or a surface filter are the streamwise and spanwise correlation lengths. The challenges to represent this wide range of surface conditions and potential scales to characterize engineering roughness including biofouling in predictive correlations will be discussed.https://cassyni-user-files-prod.s3.amazonaws.com/TPr3zpkrD8Uy5us3VjKjUi https://cassyni.com/slides/outline/4nLv1bgXsZdEYdygfRAavq https://cassyni.com/events/4nLv1bgXsZdEYdygfRAavq/abstract https://cassyni-user-files-prod.s3.amazonaws.com/MxiQVJe5P6PZxWHFV75qXL https://cassyni.com/events/4nLv1bgXsZdEYdygfRAavq?videoPreview=1 Extreme Events in Fluid Dynamics: Mechanisms, Prediction and Mitigationnohttps://cassyni.com/events/4nLv1bgXsZdEYdygfRAavq?videoPreview=12021-03-12T16:00:00+00:003892.8Journal of Fluid MechanicsA wide range of natural and engineering systems exhibit extreme events, i.e., spontaneous intermittent behavior manifested through sporadic bursts in the time series of their observables. Examples include ocean rogue waves, intermittency in turbulence, extreme weather patterns and epileptic seizure. Because of their undesirable impact on the system or the surrounding environment, the real-time prediction and mitigation of extreme events is of great interest. In this talk, I will discuss three aspects of extreme events. First, I introduce a variational method that unveils the mechanisms underpinning the formation of extreme events. Next, I show how this framework enables the data-driven, real-time prediction of extreme events. I demonstrate the application of this method with several examples, including the prediction of ocean rogue waves and the intermittent energy dissipation bursts in turbulent fluid flows. Finally, I will discuss a closed-loop adaptive control and a delay feedback control for mitigating extreme events.https://cassyni-user-files-prod.s3.amazonaws.com/MxiQVJe5P6PZxWHFV75qXL https://cassyni.com/slides/outline/DBNBoDgTLM3DhyL9jGVe9j https://cassyni.com/events/DBNBoDgTLM3DhyL9jGVe9j/abstract https://cassyni-user-files-prod.s3.amazonaws.com/23in9WF8QDSGoyu6Q1nSeJ https://cassyni.com/slides/outline/FecD2dv5Xdoi4uoiGxQGsf https://cassyni.com/events/FecD2dv5Xdoi4uoiGxQGsf/abstract https://cassyni-user-files-prod.s3.amazonaws.com/7c1pvCGnLcfKwshtDDBdzN https://cassyni.com/events/FecD2dv5Xdoi4uoiGxQGsf?videoPreview=1 Microscopic Auxetic Hierarchical Mechanical Metamaterials exhibiting controllable Mechanical Properties and Shape Morphingnohttps://cassyni.com/events/FecD2dv5Xdoi4uoiGxQGsf?videoPreview=12022-07-06T09:10:00+00:001172.04ETOPIMShape morphing [1, 2, 3] and the ability to control mechanical properties of functional materials [4, 5] remain some of the biggest challenges in the field of materials science. This stems from the fact that these properties, with the emphasis on the unusual types of mechanical behavior such as the auxeticity or negative stiffness, are of great significance in the case of numerous applications. Some of these applications include protective equipment, vibration damping and biomedical devices. Particularly important in this regard is a recent progress made in the field of hierarchical mechanical metamaterial [6, 7], i.e. structures composed of components being able to deform irrespectively to the rest of the system. The concept of hierarchy implemented in mechanical metamaterials enables them to exhibit a range of different mechanical properties without being reconstructed. This in turn makes it possible to potentially construct mechanical metamaterials capable of adjusting their mechanical response depending on the external stimulus. Nevertheless, despite several significant achievements reported in this field, studies related to hierarchical mechanical metamaterials are still at the very early stage and hierarchical structures reported in the literature normally share several limitations. First of all, it is worth mentioning that a vast majority of known hierarchical metamaterials are two-dimensional which significantly limits their applicability since they cannot respond to the stimulus applied from an arbitrary direction. However, an even larger limitation is the fact that the behavior of the currently known hierarchical mechanical metamaterials has been primarily studied at the microscale. On the other hand, the possibility of such a system to exhibit the programmable shape morphing would be of great significance at the much lower scales including the microscale where it could be utilized in the design of novel robotics and biomedical devices. In this work, we propose a novel microscopic 2D and 3D hierarchical metamaterial capable of exhibiting a wide range of auxetic behavior depending on the variation in its geometric parameters. We also show that the considered system is capable of shape morphing at the microscale where it can assume an arbitrary predefined shape. Finally, we show that in addition to the auxetic behavior, the considered hierarchical structure can exhibit very different rates of energy absorption and different values of stiffness. All of these results indicate that the proposed concept can be utilized in the design of novel types of robotics as well as protective equipment and vibration damping materials.https://cassyni-user-files-prod.s3.amazonaws.com/7c1pvCGnLcfKwshtDDBdzN https://cassyni.com/slides/outline/CC4yhrPQTRw53DW9dJ2KLq https://cassyni.com/events/CC4yhrPQTRw53DW9dJ2KLq/abstract https://cassyni-user-files-prod.s3.amazonaws.com/5cimqAsgQYqSmWN72sCCWA https://cassyni.com/events/CC4yhrPQTRw53DW9dJ2KLq?videoPreview=1 Time-modulated metamaterialsnohttps://cassyni.com/events/CC4yhrPQTRw53DW9dJ2KLq?videoPreview=12022-07-08T06:40:00+00:003033.04ETOPIMOur aim is to survey mathematical and computational frameworks to elucidate physical mechanisms for manipulating waves in a robust way at scales beyond the diffraction limit using subwavelength resonator systems. In particular, we demonstrate large-scale effective parameters with exotic values. We also show that these systems can exhibit localized and guided waves on very small length scales. Using the concept of topologically protected edge modes, such localization can be made robust against structural imperfections. Then we consider time-modulated systems of subwavelength resonators and prove in particular the possibility of achieving non-reciprocal wave propagation and obtaining zero-refractive index materials in the subwavelength regime.https://cassyni-user-files-prod.s3.amazonaws.com/5cimqAsgQYqSmWN72sCCWA https://cassyni.com/slides/outline/NZiHnqVK5QVDiCVgvxueey https://cassyni.com/events/NZiHnqVK5QVDiCVgvxueey/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Y6pYHFyASfUicorUpoCn5k https://cassyni.com/events/NZiHnqVK5QVDiCVgvxueey?videoPreview=1 Hypergestures: Body as Brandnohttps://cassyni.com/events/NZiHnqVK5QVDiCVgvxueey?videoPreview=12022-11-30T01:00:00+00:002917.8Department of MarketingFrom political salutes to footballers’ celebrations, organisations and consumers are using gestures like a logo or name to signify brands and social membership. These gestures related to brands perform the key functions of other brand elements whilst appearing to offer unique affordances associated with the gestural mode, including enhancing communication and acting as an embodied shortcut to social identity. With the rise of apps such as TikTok, which prioritises bodily movements, these gestures may be growing in popularity. However, whilst marketing research continues to highlight the unique benefits of new modes of branding, brand-related gestures remain unidentified and scarcely explored. My proposed research will identify and describe these conventionalised gestures, or “hypergestures”, for the first time and explore how they may influence consumer behaviour. I aim to contribute to embodied cognition and social identity theory in branding literature and offer practical implications for organisations wishing to leverage hypergestures.https://cassyni-user-files-prod.s3.amazonaws.com/Y6pYHFyASfUicorUpoCn5k https://cassyni.com/events/P4MtqX8qWs3Ghy2aXQCSvH/abstract https://cassyni-user-files-prod.s3.amazonaws.com/PKVpNBfmb6unt15ayESZEv https://cassyni.com/events/VySMV6CBfGo4Cn29tqmP4y/abstract https://cassyni-user-files-prod.s3.amazonaws.com/2JTLvvCzsDVMicV8bsMTfU https://cassyni.com/events/VySMV6CBfGo4Cn29tqmP4y?videoPreview=1 Experimentalism and Sociology: From Crisis to Experiencenohttps://cassyni.com/events/VySMV6CBfGo4Cn29tqmP4y?videoPreview=12023-01-24T17:00:00+00:005670.84SpringerHas society become a “real-world laboratory”? Tanja Bogusz asks this question in her book as she traces back the experimentalist approach from early American pragmatism to contemporary world society. She recommends that sociology, as a discipline, transform from a science of crisis towards an experimental science of experience, focusing on heterogeneous cooperation to overcome the epistemic disparities of our time. The speakers will discuss the book’s core ideas, as well as its impact on current global challenges. Springer, in association with the Center for Sustainable Society (CSS), University of Hamburg, is delighted to invite you to join the author and the internationally renowned panellists at this online event. Professor Stefan Aykut, Director, CSS, will begin the event with a short introduction on the center's programs. https://cassyni-user-files-prod.s3.amazonaws.com/2JTLvvCzsDVMicV8bsMTfU https://cassyni.com/slides/outline/YSgNiWRorZZYZiViSXg1nu https://cassyni.com/events/YSgNiWRorZZYZiViSXg1nu/abstract https://cassyni-user-files-prod.s3.amazonaws.com/QHmBFwX9wtcrDpbG9NCpUW https://cassyni.com/events/YSgNiWRorZZYZiViSXg1nu?videoPreview=1 Denoising of radar images by AI.nohttps://cassyni.com/events/YSgNiWRorZZYZiViSXg1nu?videoPreview=12022-12-06T14:00:00+00:002077.12MetaMATRonald Aznavourian¹, Jérôme Lanteri², Claire Migliaccio², Julien Marot¹ [1]: CNRS, Aix Marseille Université, Centrale Marseille, Institut Fresnel UMR 7249, Marseille, France, [ronald.aznavourian@fresnel.fr](ronald.aznavourian@fresnel.fr),[julien.marot@fresnel.fr](julien.marot@fresnel.fr) [2]: Laboratoire d’Électronique, Antennes et Télécommunications, Université Cote d’Azur, Nice, France,[jerome.lanteri@univ-cotedazur.fr](jerome.lanteri@univ-cotedazur.fr),[claire.migliaccio@univ-cotedazur.fr](claire.migliaccio@univ-cotedazur.fr) ## Abstract A lot of applications are possible with AI: classification, to sort a lot of images in many different categories, denoising, to improve the quality of a signal or an image, and “generative”, to create a fake image which seems to be very real. Here, I propose to use an autoencoder to denoise radar images. In order to achieve this, I first propose to create an adequate dataset of 60,000 images to train the autoencoder. ## Characterisation In the context of public space planning, the movement of pedestrians and cyclists is studied using radar images. More precisely, we sample in time, the distances between people or cyclists with a radar. By joining all the images acquired at each moment of capture, and that, during a period of time, one obtains the curves (generally rather rectilinear) of displacement of the pedestrians and cyclists. An example is given in Fig. 1. Unfortunately, the data acquisition equipment is not perfect, and the images obtained in this way are strongly distorted. In order to continue processing these data, it is imperative to remove the spurious data. To do this, there are different methods of "denoising" (Wiener filtering1, ACP2, …), and the one that seems to be the most effective is the one that consists of using an autoencoder. An autoencoder is an application of neural networks, and like all neural networks, it needs to be properly trained to be efficient. Indeed, to have tested a trained autoencoder on a dataset of 60 000 images representing numbers, we obtain crude images looking more like numbers than pedestrians and cyclists movement curves, as we can see it, in Fig. 2. I therefore propose a way to generate 60 000 images comparable to the images of the studied domain, in order to generate the dataset necessary for the training of the autoencoder, then to apply the autoencoder thus trained, on the acquired and noisy images, in order to denoise them.https://cassyni-user-files-prod.s3.amazonaws.com/QHmBFwX9wtcrDpbG9NCpUW https://cassyni.com/slides/outline/R2xK2FiwGhG2ogJotN4PLq https://cassyni.com/events/R2xK2FiwGhG2ogJotN4PLq/abstract https://cassyni-user-files-prod.s3.amazonaws.com/CQ3iyjbWkeXALRbyU68hjt https://cassyni.com/events/R2xK2FiwGhG2ogJotN4PLq?videoPreview=1 Turbulence, Periodic Orbits and Koopman Analysisnohttps://cassyni.com/events/R2xK2FiwGhG2ogJotN4PLq?videoPreview=12019-03-07T11:30:00+00:003193.08UK Fluids NetworkPeriodic orbits are known to be very important in describing chaotic attractors and the hope has been that they may also help our understanding of fluid turbulence. I'll discuss work trying to find periodic orbits buried in turbulent flows which, most recently, has utilised Dynamic Mode Decomposition/Koopman analysis.https://cassyni-user-files-prod.s3.amazonaws.com/CQ3iyjbWkeXALRbyU68hjt https://cassyni.com/slides/outline/2on7wVcKX6La1AVduqNvP7 https://cassyni.com/events/2on7wVcKX6La1AVduqNvP7/abstract https://cassyni-user-files-prod.s3.amazonaws.com/XUnZRh1UKRsVZciVWg2sdx https://cassyni.com/events/2on7wVcKX6La1AVduqNvP7?videoPreview=1 Photonic topological metamaterials built of sub-wavelength resonatorsnohttps://cassyni.com/events/2on7wVcKX6La1AVduqNvP7?videoPreview=12023-02-14T14:00:00+00:003964.28MetaMATArranging many identical entities (atoms, dielectric spheres, etc.) having the same resonant frequency in a dense two-dimensional structure and breaking the time-reversal symmetry by an external magnetic field may result in a photonic metamaterial with nontrivial topological properties. When the structure is periodic, the resulting topological bandgaps are characterized by non-zero Chern numbers and host topologically protected edge modes. Disorder in positions of resonators introduce localized modes inside the bandgap and eventually closes the latter when made sufficiently strong. More interestingly, disorder can also induce topological properties in an otherwise topologically trivial structure – a phenomenon known as the topological Anderson insulator. The resonant nature of scattering, the vector character of light, and the strong near-field coupling between neighboring resonators are at the origin of differences in behavior of the considered photonic structure with respect to electronic systems.https://cassyni-user-files-prod.s3.amazonaws.com/XUnZRh1UKRsVZciVWg2sdx https://cassyni.com/slides/outline/TWCLFfxZTz2XAcnNS3y24m https://cassyni.com/events/TWCLFfxZTz2XAcnNS3y24m/abstract https://cassyni-user-files-prod.s3.amazonaws.com/TwA38wJXAvtPQDYb4YHByx https://cassyni.com/events/TWCLFfxZTz2XAcnNS3y24m?videoPreview=1 Co-clustering Analysis of Multidimensional Big Datanohttps://cassyni.com/events/TWCLFfxZTz2XAcnNS3y24m?videoPreview=12021-09-08T09:00:00+00:002819.88DataSıgAlthough a multidimensional data array can be very large, it may contain coherence patterns much smaller in size. For example, we may need to detect a subset of genes that co-express under a subset of conditions. In this presentation, we discuss our recently developed co-clustering algorithms for the extraction and analysis of coherent patterns in big datasets. In our method, a co-cluster, corresponding to a coherent pattern, is represented as a low-rank tensor and it can be detected from the intersection of hyperplanes in a high dimensional data space. Our method has been used successfully for DNA and protein data analysis, disease diagnosis, drug therapeutic effect assessment, and feature selection in human facial expression classification. Our method can also be useful for many other real-world data mining, image processing and pattern recognition applications.https://cassyni-user-files-prod.s3.amazonaws.com/TwA38wJXAvtPQDYb4YHByx https://cassyni.com/slides/outline/Dg3QxXqsBAX3XSKfXNccKw https://cassyni.com/events/Dg3QxXqsBAX3XSKfXNccKw/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Cpqgo4ZvgeZ2vnr1b22q9Q https://cassyni.com/events/Dg3QxXqsBAX3XSKfXNccKw?videoPreview=1 A Novel Diffuse-Interface Method for Compressible Multiphase Flowsnohttps://cassyni.com/events/Dg3QxXqsBAX3XSKfXNccKw?videoPreview=12023-01-16T16:00:00+00:003820.92Journal of Computational PhysicsMultiphase flows have a wide range of applications in natural and engineering processes. In this talk, I’ll present a novel diffuse-interface model and robust numerical methods for simulations of compressible multiphase flows. I’ll first present the accurate conservative diffuse-interface/phase-field (ACDI) model for the simulation of multiphase flows. This method conserves the mass of each of the phases, and results in bounded transport of the volume fraction while maintaining the interface thickness on the order of only one to two grid points. I’ll present results from the canonical test cases, showing the improvement in the accuracy of interface shape and surface tension forces over the commonly used second-order conservative phase-field method. The capability of the ACDI model to maintain such sharp interfaces without the need for any special geometric treatment, unlike the sharp-interface methods, makes it a highly attractive interface-capturing method for accurate simulation of multiphase flows at an affordable cost. Next, for the simulation of compressible multiphase flows, a five-equation model that consists of transport equations for the volume fraction, the mass of each phase, momentum, and total energy is used. Starting from this baseline five-equation model, I’ll present modifications to the model in such a way that the resulting system of equations can be discretized using a non-dissipative central scheme that is suitable for the simulation of turbulent flows. The resulting model is conservative, accurate, scalable, and maintains a constant interface thickness throughout the simulation. I will present simulations of canonical and complex turbulent compressible multiphase flows. For stable and accurate numerical simulations of compressible flows, particularly at higher Reynolds numbers (Re), it is known that a discrete entropy condition needs to be satisfied in addition to the discrete conservation of kinetic energy. I’ll present a numerical flux formulation for the five-equation model that satisfies this condition (a KEEP scheme) and show that this formulation results in stable numerical simulations of compressible turbulent multiphase flows at high Re. Finally, I’ll briefly highlight some of the related research efforts on the use of these methods for the simulation of shock-interface interaction problems, phase change, and multi-material systems. https://cassyni-user-files-prod.s3.amazonaws.com/Cpqgo4ZvgeZ2vnr1b22q9Q https://cassyni.com/events/ADWBdkKC6xeQVk26siEeo7/seminar/qa https://cassyni.com/slides/outline/ADWBdkKC6xeQVk26siEeo7 https://cassyni.com/events/ADWBdkKC6xeQVk26siEeo7/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Sf8SrUGUCtMsAZk29TKArJ https://cassyni.com/events/ADWBdkKC6xeQVk26siEeo7?videoPreview=1 Renal Anaemianohttps://cassyni.com/events/ADWBdkKC6xeQVk26siEeo7?videoPreview=12023-03-10T16:30:00+00:002707.52Dialysis GroupDebate: IV Iron is good for you - the case is closedhttps://cassyni-user-files-prod.s3.amazonaws.com/Sf8SrUGUCtMsAZk29TKArJ https://cassyni.com/events/CgkCsAYpJFQtrgVfRQ9HX3/seminar/qa https://cassyni.com/slides/outline/CgkCsAYpJFQtrgVfRQ9HX3 https://cassyni.com/events/CgkCsAYpJFQtrgVfRQ9HX3/abstract https://cassyni-user-files-prod.s3.amazonaws.com/NiMxCSpZjdpcbCfn9FbFKc https://cassyni.com/events/CgkCsAYpJFQtrgVfRQ9HX3?videoPreview=1 Understanding and Improving Anode Performance in an Alkaline Membrane Electrolyzersnohttps://cassyni.com/events/CgkCsAYpJFQtrgVfRQ9HX3?videoPreview=12023-03-16T14:00:00+00:003673.0Electrochimica ActaThe massive international investment in water electrolysis has accelerated the need to reduce cost and increase durability. In recent years, Anion exchange membrane electrolyzers (AEMELs) have been touted as a possible low-cost option to supplant traditional alkaline electrolyzers and proton exchange membrane electrolyzers because they promise to combine the benefits of both – namely high current density operation, high discharge pressure, the use of noble-metal free catalysts, and the ability to use a wider range of materials for other cell components. As AEMELs are still early in their developmental stage, much of the reported work in the literature has dealt with the development of new catalysts or membranes for these devices and have worried less about engineering aspects of AEMEL design such as loading optimization, the structure and composition of the porous transport layers (PTL), the balance of IEC between the cathode, membrane and anode, etc. This presentation intends to take the audience through a systematic optimization of the anode electrode for AEMELs. Some of the variables to be discussed are: i) IEC and cross-linker content of the ionomers; ii) ionomer physical structure; iii) catalyst loading; iv) PTL density and thickness; and v) number of layers that comprise the catalyst layer. The balance and sometimes compromise between performance and durability will also be discussed. By the end of the presentations of electrodes will be demonstrated that were integrated into AEMELs and are able to show very low voltage operation on both deionized water and 0.3 M KOH as well as stable longer-term operation.https://cassyni-user-files-prod.s3.amazonaws.com/NiMxCSpZjdpcbCfn9FbFKc https://cassyni.com/events/LaXoCt5brzpZv6buA2CwdP/seminar/qa https://cassyni.com/slides/outline/LaXoCt5brzpZv6buA2CwdP https://cassyni.com/events/LaXoCt5brzpZv6buA2CwdP/abstract https://cassyni-user-files-prod.s3.amazonaws.com/uYb5dFtfthPsMPGF4kuki https://cassyni.com/events/LaXoCt5brzpZv6buA2CwdP?videoPreview=1 REACH Casual Friday: Automate Your Excel Workflow with Power Querynohttps://cassyni.com/events/LaXoCt5brzpZv6buA2CwdP?videoPreview=12025-11-21T18:00:00+00:002670.64Research Evaluation and Analytics Capacity Hub## This month's Casual Friday Topic: Automate Your Excel Workflow with Power Query In our REACH Casual Friday events we aim to gather virtually with network participants, especially those participating in RAMP. The first 30-minutes will be a focused presenter and topic followed by more causal networking and possible break-out rooms. In this presentation, you will learn to streamline the process of updating Excel reports using Power Query. I will demonstrate two workflows, manual vs Power Query, to update a research analytics report. We will contrast those workflows, then introduce the Power Query editor environment, basic functions such as sort and filter, and intermediate functions such as joining tables and creating custom columns. This presentation is intended for report builders who are familiar with Excel and likely have some experience using pivot tables.https://cassyni-user-files-prod.s3.amazonaws.com/uYb5dFtfthPsMPGF4kuki https://cassyni.com/slides/outline/oazBypukdb5GGBb8nDLzR https://cassyni.com/events/oazBypukdb5GGBb8nDLzR/abstract https://cassyni-user-files-prod.s3.amazonaws.com/72pjhDEfyix79UkmrozKYi https://cassyni.com/events/oazBypukdb5GGBb8nDLzR?videoPreview=1 Building Foundations for AI Success: Data Infrastructure and Culture for Effective Implementationnohttps://cassyni.com/events/oazBypukdb5GGBb8nDLzR?videoPreview=12026-01-29T14:00:00+00:003704.28AAMCThis session examined how AI could transform medical education while addressing common infrastructure and capacity challenges to adoption. Speakers shared practical strategies for building a foundation for responsible AI integration, including data governance, institutional culture, and infrastructure, alongside real-world use cases and adaptable tools. Attendees gained actionable insights to navigate barriers to adoption and explored best practices for sustainable implementation. This webinar is part of the Artificial Intelligence in Academic Medicine Webinar Series, hosted by the AAMC. It explores critical concepts, the current landscape, and practical strategies drawn from various perspectives and institutions to support you in navigating the evolving world of AI in academic medicine. For more information, see [the complete series webpage](https://www.aamc.org/about-us/mission-areas/medical-education/artificial-intelligence-ai-academic-medicine-webinar-series).https://cassyni-user-files-prod.s3.amazonaws.com/72pjhDEfyix79UkmrozKYi https://cassyni.com/slides/outline/PYE4gaMYgDf2FTjYJAqHCH https://cassyni.com/events/PYE4gaMYgDf2FTjYJAqHCH/abstract https://cassyni-user-files-prod.s3.amazonaws.com/6u8Q1bHHESnTTDQyjDqQVC https://cassyni.com/events/PYE4gaMYgDf2FTjYJAqHCH?videoPreview=1 Science Advocacy in Action: From Nucleus to Cytoplasmnohttps://cassyni.com/events/PYE4gaMYgDf2FTjYJAqHCH?videoPreview=12026-05-04T06:00:00+00:001038.44Journal of VirologyUnderstanding how Kaposi’s sarcoma–associated herpesvirus (KSHV) traverses the nuclear environment is essential for revealing weak points in the viral life cycle, and this work offers a transformative look at that process. By identifying the nucleoplasmic reticulum (NR) as a functional conduit for primary envelopment and nuclear egress, the research updates long‑standing models of herpesvirus biology and uncovers new host–virus interfaces that may be exploited therapeutically. The ability to track individually labeled viral genomes in live cells deepens mechanistic insight into early lytic replication and supports the development of antiviral strategies designed to disrupt nuclear egress before virions reach the cytoplasm. https://cassyni-user-files-prod.s3.amazonaws.com/6u8Q1bHHESnTTDQyjDqQVC https://cassyni.com/events/T2FJ4jCC6Ydb9ZuJ4iFYJh/seminar/qa https://cassyni.com/slides/outline/T2FJ4jCC6Ydb9ZuJ4iFYJh https://cassyni.com/events/T2FJ4jCC6Ydb9ZuJ4iFYJh/abstract https://cassyni-user-files-prod.s3.amazonaws.com/FhRogDN2CaLropQj5NwhpS https://cassyni.com/events/T2FJ4jCC6Ydb9ZuJ4iFYJh?videoPreview=1 A brief natural history of misinformationnohttps://cassyni.com/events/T2FJ4jCC6Ydb9ZuJ4iFYJh?videoPreview=12026-03-23T16:00:00+00:003446.64Royal Society PublishingThe idea that organisms benefit by acquiring information through social connections is a cornerstone of our understanding of social evolution and collective behaviour. Yet, while learning about the world through social ties can confer many benefits, these connections can also serve as conduits for misinformation. Studies of misinformation in human social systems are rapidly proliferating, yet our understanding of the biological origins of misinformation remains surprisingly limited. In this review, we survey examples of socially transmitted misinformation across biological systems. Our central findings are (i) that the transmission and use of misinformation is widespread in biological systems spanning levels of organization, and (ii) that the production and transmission of misinformation is probably an inevitable property that inherits from fundamental constraints on biological communication systems, rather than a pathology that lies apart from the normal functioning of such systems. In this light, we argue that there is a need for a more integrated theoretical and empirical science of misinformation in biology. We end by highlighting four emerging questions about misinformation and its role in driving ecological and evolutionary dynamics that this new field of inquiry should address.https://cassyni-user-files-prod.s3.amazonaws.com/FhRogDN2CaLropQj5NwhpS https://cassyni.com/events/8FdxRP88pWWYCSrJwWnCnh/seminar/qa https://cassyni.com/slides/outline/8FdxRP88pWWYCSrJwWnCnh https://cassyni.com/events/8FdxRP88pWWYCSrJwWnCnh/abstract https://cassyni-user-files-prod.s3.amazonaws.com/R6p3EZ5s3KPBFXXmkWhWv https://cassyni.com/events/8FdxRP88pWWYCSrJwWnCnh?videoPreview=1 Mixing Skyrmions and Merons in Topological Quasicrystals of Evanescent Optical Fieldnohttps://cassyni.com/events/8FdxRP88pWWYCSrJwWnCnh?videoPreview=12024-11-05T14:00:00+00:003110.04MetaMATPhotonic skyrmion and meron lattices are structured light fields with topologically protected textures, analogous to magnetic skyrmions and merons. In this talk, I report the theoretical existence of mixed skyrmion and meron quasicrystals in an evanescent optical field. Topological quasiperiodic tilings of even and odd point group symmetries are demonstrated in both the electric field and spin angular momentum. These quasicrystals contain both skyrmions and merons of Néel-type topology, marking the first demonstration of quasiperiodic tilings of such quasiparticles in a three-dimensional vector field. These results are in agreement with the observations of quasiperiodic arrangements of carbon nanoparticles in water driven by ultrasound, and pave the way towards engineering hybrid topological states of light, which may have potential applications in optical manipulation, metrology and information processing.https://cassyni-user-files-prod.s3.amazonaws.com/R6p3EZ5s3KPBFXXmkWhWv https://cassyni.com/events/AEENc7iEaLjJJA8YJUe9DF/seminar/qa https://cassyni.com/slides/outline/AEENc7iEaLjJJA8YJUe9DF https://cassyni.com/events/AEENc7iEaLjJJA8YJUe9DF/abstract https://cassyni-user-files-prod.s3.amazonaws.com/A9ntxeAVsdP92ckyqCMeYN https://cassyni.com/events/AEENc7iEaLjJJA8YJUe9DF?videoPreview=1 What is the graph of a dynamical system?nohttps://cassyni.com/events/AEENc7iEaLjJJA8YJUe9DF?videoPreview=12024-11-12T14:00:00+00:002553.28Nonlinear Dynamics, an International Journal of Nonlinear Dynamics and Chaos in Engineering SystemsFrequently we describe a dynamical system in terms of an attractor. That can leave out important information about unstable invariant sets. These represent hidden behavior that can become important when the system is perturbed. The graph of a dynamical system enables us to try to encapsulate some of the complexity. Some examples of why this is important will be presented, from the very simple to the very complex.https://cassyni-user-files-prod.s3.amazonaws.com/A9ntxeAVsdP92ckyqCMeYN https://cassyni.com/events/UzvabMKx4TdAHFknvQQJc5/seminar/qa https://cassyni.com/slides/outline/UzvabMKx4TdAHFknvQQJc5 https://cassyni.com/events/UzvabMKx4TdAHFknvQQJc5/abstract https://cassyni-user-files-prod.s3.amazonaws.com/ToU43PiAcCV4wMKmwDVvZC https://cassyni.com/events/UzvabMKx4TdAHFknvQQJc5?videoPreview=1 Dynamics of time-varying elastic metamaterialsnohttps://cassyni.com/events/UzvabMKx4TdAHFknvQQJc5?videoPreview=12024-12-03T14:00:00+00:003317.04MetaMATThis talk explores the fascinating dynamics of elastic metamaterials under time-varying modulation, shedding light on the transformation of both standing and wave modes. In the first part, the focus is on standing mode transformations in topological and nontopological structures driven by slow and fast time modulation. The critical role of modulation velocity in enabling edge-to-edge energy transfer is highlighted, with the transition between successful and unsuccessful transformations explained using the adiabatic theorem. These ideas are discussed through numerical simulations of spring-mass lattices and experimental demonstrations on time-varying electromechanical beams. The second part is instead focused on wave mode transformations in time-modulated systems, where intriguing phenomena such as frequency conversion, wave steering, trapping, and mode conversion take center stage. These effects are illustrated with examples from spring-mass lattices and elastic half-planes. The talk wraps up with early steps toward implementing these concepts in micro-electromechanical systems. https://cassyni-user-files-prod.s3.amazonaws.com/ToU43PiAcCV4wMKmwDVvZC https://cassyni.com/slides/outline/DgmbvuEueYbwKrS6x926k5 https://cassyni.com/events/DgmbvuEueYbwKrS6x926k5/abstract https://cassyni-user-files-prod.s3.amazonaws.com/HiQwu8Znbokzq64Lhy9qgA https://cassyni.com/slides/outline/M6XHjnTfdmqVyDEpARRc1s https://cassyni.com/events/M6XHjnTfdmqVyDEpARRc1s/abstract https://cassyni-user-files-prod.s3.amazonaws.com/VbrCsewazp5wWv2jr2MUTY https://cassyni.com/events/M6XHjnTfdmqVyDEpARRc1s?videoPreview=1 My Digital Gut: a tool set for microbiome-mediated precision nutrition - Pacific eventnohttps://cassyni.com/events/M6XHjnTfdmqVyDEpARRc1s?videoPreview=12024-12-04T01:00:00+00:002040.0Microbiome Virtual International ForumVariable responses to diet are mediated, to a large degree, by inter-individual variation in the composition of the gut microbiota. However, mapping ecological composition of the gut microbiome to its functional outputs, at scale, in the context of individual-specific dietary intake poses a daunting challenge. Furthermore, tracking dietary intake through gold-standard questionnaires is costly, requires high levels of compliance from participants, and is prone to reporting biases. In this talk, I present recent progress towards building a gut digital twin, which can be used to simulate personalized responses to dietary and probiotic interventions. I also present a novel data-driven diet tracking tool, which can be leveraged to estimate dietary intake directly from stool metagenomic data. Together, these tools are designed to empower high-throughput, microbiome-mediated precision nutrition.https://cassyni-user-files-prod.s3.amazonaws.com/VbrCsewazp5wWv2jr2MUTY https://cassyni.com/slides/outline/PZmJyChHq4bzL9iNi7LEjo https://cassyni.com/events/PZmJyChHq4bzL9iNi7LEjo/abstract https://cassyni-user-files-prod.s3.amazonaws.com/XcNYjtm1fhEvudeoN3NXgA https://cassyni.com/events/PZmJyChHq4bzL9iNi7LEjo?videoPreview=1 Generating Functions of Key Polynomials and Bounded Ascending Sequences of Integersnohttps://cassyni.com/events/PZmJyChHq4bzL9iNi7LEjo?videoPreview=12024-10-15T15:00:00+00:003625.68The Journal of Algebraic CombinatoricsThe fact that Schubert polynomials are the weighted counting functions for reduced RC-graphs, also known as reduced pipe dreams, was established using their generating functions inside an appropriate Demazure algebra. In this talk we present a work in progress with Noah Cape investigating the generating functions of another family of polynomials, the key polynomials, also known as Demazure characters. Each component in that function is a rational function, whose denominator is an explicit product whose definition is based on bounded ascending sequences of integers. We can also determine the first terms of the polynomial numerator, and we introduce resulting conjectural relations between the coefficients in key polynomials and signed sums of numbers of integral points on polytopes.https://cassyni-user-files-prod.s3.amazonaws.com/XcNYjtm1fhEvudeoN3NXgA https://cassyni.com/slides/outline/L7E5eRAckrjMJTQp4SxHCy https://cassyni.com/events/L7E5eRAckrjMJTQp4SxHCy/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Ccyh4mXmCcnSmWztgBrmxJ https://cassyni.com/events/L7E5eRAckrjMJTQp4SxHCy?videoPreview=1 1.5 The Legal and Policy Context: ScholComm is Sharingnohttps://cassyni.com/events/L7E5eRAckrjMJTQp4SxHCy?videoPreview=12024-12-06T17:00:00+00:003500.88Medical Library Association’s Scholarly Communications CaucusDiscuss copyright, licensing, and academic authors' rights, and how legal frameworks shape scholarly work.https://cassyni-user-files-prod.s3.amazonaws.com/Ccyh4mXmCcnSmWztgBrmxJ https://cassyni.com/events/U1dNVz2uBYX1cVvnpRvyoB/seminar/qa https://cassyni.com/slides/outline/U1dNVz2uBYX1cVvnpRvyoB https://cassyni.com/events/U1dNVz2uBYX1cVvnpRvyoB/abstract https://cassyni-user-files-prod.s3.amazonaws.com/XZoALopcGv5yCy9NcALZZx https://cassyni.com/events/U1dNVz2uBYX1cVvnpRvyoB?videoPreview=1 Guided elastic waves in soft elastomers: from topology to space-time interfacesnohttps://cassyni.com/events/U1dNVz2uBYX1cVvnpRvyoB?videoPreview=12025-02-04T14:00:00+00:003129.04MetaMATMechanical waves propagating in soft elastomers offer a rich platform for exploring novel wave phenomena with broad implications across science and technology. These materials, often characterized by their near incompressibility, exhibit unique wave behaviors that differ significantly from those in traditional solids. The longitudinal wave velocity ($V_L$) in these soft materials is much higher than the transverse wave velocity ($V_T$), which gives rise to intriguing phenomena when elastic waves propagate in them. In this talk, we will present a comprehensive description of the experimental setup developed to study guided waves in soft elastomers, allowing us to probe wave propagation with high precision. By exploiting the flexibility of this platform, we will demonstrate several previously unobserved effects in wave dynamics, including the emergence of Dirac cones, chiral wave propagation, and the ability to control wave behaviors using external stimuli. Additionally, we will explore the potential of externally manipulating the propagation to observe the crossing of spatio-temporal boundaries by wave packets.https://cassyni-user-files-prod.s3.amazonaws.com/XZoALopcGv5yCy9NcALZZx https://cassyni.com/events/GeiUSG9q61n2LFweTSVCnH/seminar/qa https://cassyni.com/slides/outline/GeiUSG9q61n2LFweTSVCnH https://cassyni.com/events/GeiUSG9q61n2LFweTSVCnH/abstract https://cassyni-user-files-prod.s3.amazonaws.com/BTF9ZNfggxiKcehCFnSqjc https://cassyni.com/events/GeiUSG9q61n2LFweTSVCnH?videoPreview=1 Unraveling the Role of Gravity in Shaping Intruder Dynamics within Vibrated Granular Medianohttps://cassyni.com/events/GeiUSG9q61n2LFweTSVCnH?videoPreview=12025-01-14T12:00:00+00:004734.08Granular MatterGranular segregation may play a role in shaping the surface features of small celestial bodies such as asteroids that can be explained with the Brazil nut effect. We study intruder dynamics in granular media on board the Chinese Space Station, finding that contrary to what occurs on Earth intruders tend to descend in microgravity conditions under specific vibration parameters. Our experiments aboard the Chinese Space Station reveal a gravity-driven transition in intruder dynamics within vibrated granular media. While vibrations typically enable an intruder to ascend in a granular bed, low-gravity conditions induce it to descend under similar vibrations. Using a Hall-sensor array tracking method, we monitored the intruder’s movement throughout each vibration cycle and identified two competing mechanisms: inertia and gravity-dependent penetration. As gravity decreases, we observed a significant reduction in the scaled damping coefficient and hydrostatic pressure coefficient indicating that bed particles disperse more readily upon intruder impact, facilitating deeper penetration. Our findings highlight a critical transition from downward to upward motion of the intruder as vibration acceleration exceeds a threshold, which increases as gravity decreases. These insights into intruder dynamics in low-gravity environments have implications for asteroid exploration and lunar base construction, enhancing our understanding of the Brazil nut effect and the formation of planetesimal.https://cassyni-user-files-prod.s3.amazonaws.com/BTF9ZNfggxiKcehCFnSqjc https://cassyni.com/events/VVbokfVMuH6z6ikJiWXGnH/seminar/qa https://cassyni.com/slides/outline/VVbokfVMuH6z6ikJiWXGnH https://cassyni.com/events/VVbokfVMuH6z6ikJiWXGnH/abstract https://cassyni-user-files-prod.s3.amazonaws.com/VXaiyMUiVPqbdUfsLS2T4r https://cassyni.com/events/VVbokfVMuH6z6ikJiWXGnH?videoPreview=1 Phylogenomics supports a single origin of terrestriality in isopodsnohttps://cassyni.com/events/VVbokfVMuH6z6ikJiWXGnH?videoPreview=12025-02-26T14:00:00+00:002362.0Royal Society PublishingTerrestriality, the adaptation to life on land, is one of the key ecological transitions, occurring numerous times across the tree of life. Within Arthropoda, there have been several independent transitions: in hexapods, myriapods, arachnids and isopods. Isopoda is a morphologically diverse order within Crustacea, with species adapted to almost every environment on Earth. The order is divided into 11 suborders with the most speciose, Oniscidea, including terrestrial isopods such as woodlice and sea-slaters. Recent molecular phylogenetic studies have challenged traditional isopod morphological taxonomy, suggesting that several well-accepted suborders, including Oniscidea, may be non-monophyletic. This implies that terrestriality may have evolved multiple times. Current molecular hypotheses, however, are based on limited sequence data. Here, I present the results of a phylogenetic analysis of publicly available isopod genome and transcriptome datasets, using 970 single-copy orthologues to estimate relationships across isopods and divergence times with molecular dating. These analyses support monophyly of terrestrial isopods and suggest conflicting relationships based on nuclear ribosomal RNA sequences may be caused by long-branch attraction. Dating analyses suggest a Permo-Carboniferous origin of isopod terrestriality, much more recently than other terrestrial arthropods.https://cassyni-user-files-prod.s3.amazonaws.com/VXaiyMUiVPqbdUfsLS2T4r https://cassyni.com/slides/outline/MbCWu6d5UbKKngEKxXYaC5 https://cassyni.com/events/MbCWu6d5UbKKngEKxXYaC5/abstract https://cassyni-user-files-prod.s3.amazonaws.com/5NnsCgSqv9Qkx56CDwkLmc https://cassyni.com/events/MbCWu6d5UbKKngEKxXYaC5?videoPreview=1 Vertical farming goes dynamicnohttps://cassyni.com/events/MbCWu6d5UbKKngEKxXYaC5?videoPreview=12024-11-26T15:00:00+00:005326.56Frontiers in Science### A visionary way to feed growing urban populations Explore how dynamic environmental conditions could revolutionize vertical farming—maximizing productivity and profitability and helping to supply nutritious food to growing populations. This complimentary, interactive event builds on a Frontiers in Science [lead article](https://www.frontiersin.org/journals/science/articles/10.3389/fsci.2024.1411259/full) promoting the use of dynamic environmental control in vertical farms to optimize crop yields, crop quality, and cost-effectiveness. You’ll hear from the article authors and other experts on the effects of altering different growing conditions—and how monitoring systems, modeling, and breeding programs can support vertical farms in supplying vitamin-rich fruits and vegetables to urban populations. You’ll also have the chance to pose questions to the expert panel of speakers. [Register here](https://events.frontiersin.org/vertical-farming-goes-dynamic/C)https://cassyni-user-files-prod.s3.amazonaws.com/5NnsCgSqv9Qkx56CDwkLmc https://cassyni.com/events/S34aRsxgq5EM52Sk4r9KFT/seminar/qa https://cassyni.com/slides/outline/S34aRsxgq5EM52Sk4r9KFT https://cassyni.com/events/S34aRsxgq5EM52Sk4r9KFT/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Wk2rEBE5oo978YYXvmpMjL https://cassyni.com/events/S34aRsxgq5EM52Sk4r9KFT?videoPreview=1 Were dinosaurs doomed to extinction? New insights from phylodynamic modelsnohttps://cassyni.com/events/S34aRsxgq5EM52Sk4r9KFT?videoPreview=12025-06-25T15:00:00+00:001705.84Cambridge PrismsNon-avian dinosaurs died out at the end of the Cretaceous period, coincident with the Chicxulub asteroid impact, at 66 Ma. However, how their diversity changed over the course of their preceding 180-million-year history is less well understood, and previous analyses have reached conflicting conclusions about the evolutionary trajectory of dinosaurs before their final extinction. This is, in large part, due to their highly fragmentary fossil record. Phylogenetic trees depicting evolutionary relationships provide additional information, including capturing a portion of lineage history that is otherwise not observable from fossil occurrence data. We investigated whether dinosaurs were declining in diversity during the latest Cretaceous using a phylodynamic modelling approach, which is more explicit and transparent than previous approaches, especially with respect to the assumptions made about how the dinosaur fossil record has been sampled. Using two alternative models, we show that based on available phylogenies we cannot currently reach a definitive conclusion about dinosaur diversification during the Cretaceous. More densely-sampled and accurate fossil timetrees, as well as models that capture more information about the quality of the dinosaur fossil record, may help to solve this debate.https://cassyni-user-files-prod.s3.amazonaws.com/Wk2rEBE5oo978YYXvmpMjL https://cassyni.com/events/UWJbfJCK2MzqRxvJcY3wyP/seminar/qa https://cassyni.com/slides/outline/UWJbfJCK2MzqRxvJcY3wyP https://cassyni.com/events/UWJbfJCK2MzqRxvJcY3wyP/abstract https://cassyni-user-files-prod.s3.amazonaws.com/PP9n3fyfKrfLS8iZLjrV18 https://cassyni.com/events/UWJbfJCK2MzqRxvJcY3wyP?videoPreview=1 International Women's Day Panel Discussionnohttps://cassyni.com/events/UWJbfJCK2MzqRxvJcY3wyP?videoPreview=12025-03-11T21:00:00+00:003271.44Women's Health"I wanted to host a panel discussion seminar for International Women’s Day in Women’s Health to highlight the diverse and often overlooked aspects of women’s health research, ensuring inclusivity beyond cisgender women. This seminar brings together experts from multidisciplinary fields to address key challenges, disparities, and innovations in women’s health globally, particularly amplifying voices from underrepresented communities. By fostering dialogue among researchers, clinicians, and policymakers, the discussion aims to drive forward more equitable and comprehensive healthcare solutions for all individuals impacted by women’s health issues." Stephanie Shroot Commissioning Editor for Women's Healthhttps://cassyni-user-files-prod.s3.amazonaws.com/PP9n3fyfKrfLS8iZLjrV18 https://cassyni.com/slides/outline/J8fHaK6QQPSgkyvmJsAcfF https://cassyni.com/events/J8fHaK6QQPSgkyvmJsAcfF/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Gf4VSQt4CRKPhhXi9ZVAb8 https://cassyni.com/events/J8fHaK6QQPSgkyvmJsAcfF?videoPreview=1 The future of organoid intelligencenohttps://cassyni.com/events/J8fHaK6QQPSgkyvmJsAcfF?videoPreview=12023-06-21T14:00:00+00:005092.04Frontiers in ScienceHuman brains outperform computers in many forms of processing and are far more energy efficient. What if we could harness their power in a new form of biological computing? Smirnova et al. present a collaborative research program for using 3D human brain cell cultures, called brain organoids, to develop biocomputers and to better understand the brain itself. Coining the term ‘organoid intelligence’ (OI), their article – and this hub of complementary content – explores the scientific and technological advances necessary to realize this vision, as well as ethical considerations. In this Frontiers Forum Deep Dive session on 21 June 2023, Professor Thomas Hartung, Dr Lena Smirnova and other renowned researchers, explored the future of organoid intelligence and the scientific, technological and ethical steps required for realizing its full potential. The session brought together the authors of the Frontiers in Science lead article ‘Organoid intelligence (OI): the new frontier in biocomputing and intelligence-in-a-dish’ which presents a roadmap for the strategic development of organoid intelligence as a scientific discipline. It was attended by hundreds of representatives from science, policy, and business across the world. https://cassyni-user-files-prod.s3.amazonaws.com/Gf4VSQt4CRKPhhXi9ZVAb8 https://cassyni.com/slides/outline/LbuJojL2bgDB7vQKrZ5FPB https://cassyni.com/events/LbuJojL2bgDB7vQKrZ5FPB/abstract https://cassyni-user-files-prod.s3.amazonaws.com/RwgZHxFSQ2TfEmzAzwDXkA https://cassyni.com/events/LbuJojL2bgDB7vQKrZ5FPB?videoPreview=1 Learning from the past and anticipating the future in stomatal developmentnohttps://cassyni.com/events/LbuJojL2bgDB7vQKrZ5FPB?videoPreview=12024-10-21T13:00:00+00:003398.88The New Phytologist FoundationStomata provide a framework to study the fundamental processes of plants at different organizational levels, from molecules and cells to whole plants and ecosystems. And across vast temporal scales, from milliseconds to millennia. Our lab focuses on the molecules and the mechanisms that make and pattern stomata, but this work is enriched by collaborations: with ecophysiologists, who used tools derived from the molecular-scale studies to improve organismal-scale models for photosynthetic activity; with evolutionary biologists, who, taking advantage of stomatal preservation and sequencing of historic DNA, have been able to track how stomatal genes and developmental patterns change, and how this might link to climate change in the Anthropocene. In this talk, I will highlight open questions and potential places of synergy for our community to explore in the pursuit of an integrated understanding of stomatal biology.https://cassyni-user-files-prod.s3.amazonaws.com/RwgZHxFSQ2TfEmzAzwDXkA https://cassyni.com/slides/outline/XUAbpmZaFkPeeCEMU6JwL1 https://cassyni.com/events/XUAbpmZaFkPeeCEMU6JwL1/abstract https://cassyni-user-files-prod.s3.amazonaws.com/7gqzLhzLAKHSnNtwhAFZZY https://cassyni.com/events/XUAbpmZaFkPeeCEMU6JwL1?videoPreview=1 The Lack of Accessible and Culturally Sensitive Mental Health Support for Black Entrepreneursnohttps://cassyni.com/events/XUAbpmZaFkPeeCEMU6JwL1?videoPreview=12024-11-20T16:00:00+00:00702.56Center for Black Entrepreneurship, Spelman College*"Black entrepreneurs are 50% more likely to suffer from a mental health condition—yet access to culturally competent support remains scarce."* (Freeman et al., 2015) IGNITE!s “Mental Health Matters” project, supported by the Center for Black Entrepreneurship Fellowship and seed-funded by the W.K. Kellogg Foundation, addresses a critical gap in the entrepreneurial support ecosystem: the mental and emotional well-being of Black Business Owners. This initiative explored the systemic, cultural, and economic barriers that compromise mental health of Black Entrepreneurs and impede business sustainability. Using a Convergent Parallel Mixed Methods Design, the project engaged nearly 1,400 Alabama-based Black Entrepreneurs through IGNITE!s flagship DBIA Minority Business Training Pilot Program. The research uncovered deep challenges—ranging from stigma and chronic stress to economic instability and a lack of culturally relevant services—and tested a series of tailored interventions including virtual support groups, therapy access, and emotional wellness resources. Key Findings: * Mental wellness is not ancillary to business success—it is **foundational**. * Improved emotional well-being led to: * Better business outcomes * Increased entrepreneurial resilience * Reduced stigma around seeking mental health support * **IGNITE! Central**, a custom Salesforce-powered CRM, was used to: * Track real-time participant progress * Make data-informed decisions * Continuously refine and improve support pathways Through collaboration with culturally competent Mental Health Professionals, Community Advocates, Faith Leaders, Entrepreneur and/or Business Support Organizations, the initiative created a trusted, supportive ecosystem. The research findings have already begun influencing broader policy discussions around economic equity and mental health access. This project challenges traditional business development models by proving that culturally responsive mental health care is essential for sustainable entrepreneurship. IGNITE! now seeks partners to expand this work and launch a longitudinal study to evaluate long-term impacts on business growth, job creation, and wealth generation in underserved communities. https://cassyni-user-files-prod.s3.amazonaws.com/7gqzLhzLAKHSnNtwhAFZZY https://cassyni.com/slides/outline/7m5Dib2Gb8jaHyU2LR8c5s https://cassyni.com/events/7m5Dib2Gb8jaHyU2LR8c5s/abstract https://cassyni-user-files-prod.s3.amazonaws.com/9nyYQPz4X5m7EAX4wrDYDU https://cassyni.com/events/7m5Dib2Gb8jaHyU2LR8c5s?videoPreview=1 Adaptation and Optimization Using Scale-Resolving Unsteady Simulationsnohttps://cassyni.com/events/7m5Dib2Gb8jaHyU2LR8c5s?videoPreview=12024-12-05T14:00:00+00:001772.0JKW Symposium TeamScale-resolving simulations such as direct numerical simulations (DNS) and large-eddy simulations (LES) can be much more accurate but are also much more computationally expensive than steady solutions, such as Reynolds-averaged Navier-Stokes (RANS). Each scale-resolving evaluation of a quantity of interest, often a statistical time-average, requires orders of magnitude more computational time and resources than the corresponding steady-state, Reynolds-averaged evaluation. This cost inhibits the applicability of unsteady simulations to many-query studies, such as shape optimization and mesh adaptation for numerical error control. Furthermore, unsteady adjoints, already an expensive proposition, cannot be directly applied to scale-resolving problems due to their chaotic nature. The sensitivity-calculation approach proposed in this work does not use unsteady adjoint equations but instead relies on unsteady data to train a corrected turbulence model, which then yields the required adjoint solutions. It is non-intrusive and inexpensive, requiring only a small number of unsteady forward simulations, but sufficiently powerful to capture unsteady effects in the sensitivities. Results for high-order discretizations of the unsteady Navier-Stokes equations, augmented by a corrected Spalart-Allmaras turbulence closure, demonstrate the ability of the approach in driving aerodynamic shape optimization in turbulent-flow conditions, and in adapting unsteady flowfields to target statistical outputs of interest.https://cassyni-user-files-prod.s3.amazonaws.com/9nyYQPz4X5m7EAX4wrDYDU https://cassyni.com/slides/outline/4JXzPoVbWvrwGHATgkkeZ3 https://cassyni.com/events/4JXzPoVbWvrwGHATgkkeZ3/abstract https://cassyni-user-files-prod.s3.amazonaws.com/LKcrcvncSFuXK4dXtZZp3p https://cassyni.com/events/4JXzPoVbWvrwGHATgkkeZ3?videoPreview=1 Antony Jameson's contributions and lasting impact on computational aerodynamicsnohttps://cassyni.com/events/4JXzPoVbWvrwGHATgkkeZ3?videoPreview=12024-12-07T17:00:00+00:002329.6JKW Symposium TeamNo abstracthttps://cassyni-user-files-prod.s3.amazonaws.com/LKcrcvncSFuXK4dXtZZp3p https://cassyni.com/events/N5uNB3JNimivRqgTxJViHB/abstract https://cassyni-user-files-prod.s3.amazonaws.com/PtTcHzYaRQRQcgwELvsBzE https://cassyni.com/events/QZ9PQTXzv4VQnnA2VzQM17/seminar/qa https://cassyni.com/slides/outline/QZ9PQTXzv4VQnnA2VzQM17 https://cassyni.com/events/QZ9PQTXzv4VQnnA2VzQM17/abstract https://cassyni-user-files-prod.s3.amazonaws.com/MZuxSArC4TvZp2nVURsXWe https://cassyni.com/events/QZ9PQTXzv4VQnnA2VzQM17?videoPreview=1 Detonation !nohttps://cassyni.com/events/QZ9PQTXzv4VQnnA2VzQM17?videoPreview=12025-05-08T15:00:00+00:004029.64AIAA JournalA detonation is an explosion driven by energy released behind a leading shock wave traveling through a background of energetic material. It is the strongest form of combustion wave, travels orders of magnitude faster than a flame, and once it is started, it is difficult to impossible to contain until all of the fuel is consumed. Detonations may occur naturally, accidentally, and purposefully where there are energetic materials present. The highly destructive accidental detonations that occurred in large fuel storage plants, such Buncefield in the UK and Jaipur in India, lasted about two seconds. Naturally occurring detonations in Type Ia supernovae, which burn nuclear Carbon-12 to Oxygen-16, are finished in about two seconds. This presentation compresses the last 100 years’ of detonation-focused research into a brief review of some of the most important concepts. This review opens up a number of important and intriguing problems in reactive-flow physics that still need to be addressed. Finally we describe the new Detonation Research Test Facility that will be used to address some of these unresolved questions. https://cassyni-user-files-prod.s3.amazonaws.com/MZuxSArC4TvZp2nVURsXWe https://cassyni.com/events/5nWReUx4EfSukVyyaqLwY9/seminar/qa https://cassyni.com/slides/outline/5nWReUx4EfSukVyyaqLwY9 https://cassyni.com/events/5nWReUx4EfSukVyyaqLwY9/abstract https://cassyni-user-files-prod.s3.amazonaws.com/JSwGex6cYDMBiqL2B7JGx6 https://cassyni.com/events/5nWReUx4EfSukVyyaqLwY9?videoPreview=1 Presentation of EAJ Issue 15/1 - 19 May 2025nohttps://cassyni.com/events/5nWReUx4EfSukVyyaqLwY9?videoPreview=12025-05-19T15:00:00+00:003134.64European Actuarial JournalAuthors featured in the upcoming issue of the European Actuarial Journal present their paper's findings in a series of concise talks. The seminar will be chaired by Stephane Loisel, co-editor of the EAJ.https://cassyni-user-files-prod.s3.amazonaws.com/JSwGex6cYDMBiqL2B7JGx6 https://cassyni.com/events/H9RKiCq8LCBu2jy7wpniZ3/abstract https://cassyni-user-files-prod.s3.amazonaws.com/148tovd7d2s33JnFhPbZie https://cassyni.com/events/KcfLwd4kXUxPPgSgVWhMGy/abstract https://cassyni-user-files-prod.s3.amazonaws.com/49BvMCR9N9KhAhdvo6sauL https://cassyni.com/events/XxsT6iEsVvoFHMgVTsG5R7/abstract https://cassyni-user-files-prod.s3.amazonaws.com/WKYwoRhxdQfFCpNf7QdL1c https://cassyni.com/events/FfUWa9tZ1pXEc1z16Q7Jg5/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Hh6YSSVSTRKCLLWZZPip8e https://cassyni.com/events/Na8dWHDc7pP7uMwiDUzH8H/seminar/qa https://cassyni.com/slides/outline/Na8dWHDc7pP7uMwiDUzH8H https://cassyni.com/events/Na8dWHDc7pP7uMwiDUzH8H/abstract https://cassyni-user-files-prod.s3.amazonaws.com/HypvdYESYYjZronP972tXY https://cassyni.com/events/Na8dWHDc7pP7uMwiDUzH8H?videoPreview=1 On the Mathematical Modeling in Logic. An Analysis of the Structural Part of Object Determination Logic through the Formal Concept Analysisnohttps://cassyni.com/events/Na8dWHDc7pP7uMwiDUzH8H?videoPreview=12025-04-30T14:00:00+00:004631.04Logica UniversalisThe model of the structural part of Object Determination Logic (LDO) is translated and interpreted in the Formal Concept Analysis (FCA) model. In this article, we start from the premise that the modeling of a real problem has as its starting point a cognitive level that can be translated into the framework of a logic model and, subsequently, a mathematical model. We take these steps by considering the structural model of LDO, a lesser known and analyzed logic, and translating it into the FCA approach. Then, using the results of the analysis of the FCA model, we return to their interpretation within the LDO framework. Translation, i.e. the transition from the LDO model to the FCA model, is achieved by encoding in the FCA model, as faithfully as possible, each notion and constraint imposed by the LDO model. We illustrate this "methodology" by applying it to three situations corresponding to the cognitive elements of the LDO. The results obtained are interpreted from the point of view of cognitive elements of LDO. They enable us to establish the relationship between the LDO model and the FCA model, as well as the limits of each of the two models. On the basis of these limits, we propose an opening towards other types of mathematical models based on Soft Sets (SS) as parameterized sets.https://cassyni-user-files-prod.s3.amazonaws.com/HypvdYESYYjZronP972tXY https://cassyni.com/slides/outline/P4nEYxs8ZGwAu8UbovH5Pb https://cassyni.com/events/P4nEYxs8ZGwAu8UbovH5Pb/abstract https://cassyni-user-files-prod.s3.amazonaws.com/LnFP6hDxgFRk1vrF2R67gA https://cassyni.com/events/P4nEYxs8ZGwAu8UbovH5Pb?videoPreview=1 Extreme Aerodynamics: Flow Analysis and Control for Highly Gusty Conditionsnohttps://cassyni.com/events/P4nEYxs8ZGwAu8UbovH5Pb?videoPreview=12025-06-06T19:00:00+00:003367.08AI Institute in Dynamic SystemsAn air vehicle trying to operate in adverse weather or wakes of urban canyons and mountainous terrains would be hit by strong, large-scale atmospheric disturbances. In such extreme aerodynamic conditions, flight control becomes a great challenge, if not impossible, due to the enormous transient forces that the vehicle experiences. Currently, encounters with these extreme flow phenomena limit operations of fixed and rotating wing aircraft, especially those that are small to medium in size. The present study is focused on the analysis, modeling, and control of extreme aerodynamic flows, with unsteadiness far larger in amplitudes than those considered in traditional aerodynamics on a time scale comparable to those of the flow instabilities. The high dimensionality, strong nonlinearity, and multi-scale properties of these extreme flows make systematic analysis and control a tremendous challenge. Without the reduction of the state variable dimension and extraction of dominant dynamics, the application of dynamical systems and control theory for flight/flow control remains difficult. This talk will present our research group’s recent efforts to model and control such complex fluid flows by leveraging data-driven techniques. We in particular will discuss the use of unsupervised and supervised machine learning techniques and how they can be embedded in existing flow analysis techniques. Equipped with these toolsets, we extract the essential inertial manifolds of extreme aerodynamics to facilitate the development of sparse and reduced-order models to design flow control techniques. Some of the successes in characterizing, modeling, and controlling extreme aerodynamic flows will be presented, followed by discussions on open problems and outlooks. https://cassyni-user-files-prod.s3.amazonaws.com/LnFP6hDxgFRk1vrF2R67gA https://cassyni.com/slides/outline/YT6iRxA6tyTSkswjj3keGD https://cassyni.com/events/YT6iRxA6tyTSkswjj3keGD/abstract https://cassyni-user-files-prod.s3.amazonaws.com/TGw1o46PAzqj61V2ZUZLqc https://cassyni.com/events/YT6iRxA6tyTSkswjj3keGD?videoPreview=1 Biobanking of microorganisms from permafrost and glaciers of the Swiss Alpsnohttps://cassyni.com/events/YT6iRxA6tyTSkswjj3keGD?videoPreview=12025-09-09T13:30:00+00:00667.8Microbiome Virtual International ForumThe cold habitats of the Swiss Alps and the Arctic are undergoing change and are at risk of disappearing partially or completely with increasing global temperatures. Along with them, a poorly known diversity of microorganisms that have adapted to life in these supposedly hostile places. Therefore it is important to preserve this unknown microbial diversity. By cryopreserving approx. 1'500 microbial strains from these habitats, some of today's biodiversity can be preserved in biobanks. Here, we focus on the bioprospecting of Alpine and Polar microorganisms stored at long-term in the biobank to discover natural products that could be useful to us. This is especially relevant now, as these environments are among the most rapidly changing due to climate change. Over the past 20 years, we have collected soil, plastic and ice samples from a variety of Alpine and Polar environments. To bioprospect these ecosystems, we have followed two main approaches. The first involves searching our strains in the biobank for biosynthetic gene clusters, responsible for the production of secondary metabolites and genes related to plastic biodegradation by using tools that were developed for mining genomes for these gene clusters. The second approach involves a proof of concept to test of the selected strains in laboratory experiments for the abilities to produce antibiotic compounds and enzymes involved in plastic biodegradation. In both cases, our goal is to identify genes that may encode bioactive compounds or enzymes of interest—such as those with antimicrobial properties that could help us fight microbial infections and polymer degrading enzymes that might sustain a circular economy for plastic waste.https://cassyni-user-files-prod.s3.amazonaws.com/TGw1o46PAzqj61V2ZUZLqc https://cassyni.com/slides/outline/TWcfy7grWPvRMnEPia3eY5 https://cassyni.com/events/TWcfy7grWPvRMnEPia3eY5/abstract https://cassyni-user-files-prod.s3.amazonaws.com/E7FJEqXvDbWV9vaHAXdcPQ https://cassyni.com/events/TWcfy7grWPvRMnEPia3eY5?videoPreview=1 Promoting Research Integrity Through Meta Research in the Publication Processnohttps://cassyni.com/events/TWcfy7grWPvRMnEPia3eY5?videoPreview=12023-05-01T14:00:00+00:005541.32Though the vast majority of journals endorse peer review as an approach to increase trust in the literature, few make their publication process and all the associated data (e.g. submitted manuscripts, peer review reports and editorial decisions of accepted and rejected manuscripts) available to evaluate effectiveness of interventions meant to improve the quality of the publication process. We argue that scholarly journals can and should do more to apply rigorous standards to their own peer review practices by opening up their manuscript management data for meta research. In this panel discussion, we will present an overview of some of the issues in the journal publication processes that hinder research integrity, and illustrate why increased transparency is needed. Followed by a journal’s perspective of what can be done to address this will be presented and we end with two case studies as examples. https://cassyni-user-files-prod.s3.amazonaws.com/E7FJEqXvDbWV9vaHAXdcPQ https://cassyni.com/events/8FL7ATTPPYKYbCBtoGTLqs/seminar/qa https://cassyni.com/slides/outline/8FL7ATTPPYKYbCBtoGTLqs https://cassyni.com/events/8FL7ATTPPYKYbCBtoGTLqs/abstract https://cassyni-user-files-prod.s3.amazonaws.com/T5DE9kSiPt97zRRHYEX18i https://cassyni.com/events/8FL7ATTPPYKYbCBtoGTLqs?videoPreview=1 Large language models in the drug discovery: Quest for carbonic anhydrase inhibitorsnohttps://cassyni.com/events/8FL7ATTPPYKYbCBtoGTLqs?videoPreview=12025-06-20T09:15:00+00:002096.04Anti-Cancer Agents in Medicinal ChemistryLarge language models (LLMs) are transforming the landscape of drug discovery by accelerating target identification, molecular design, and data-driven predictions. This study explores the application of LLMs in the quest for novel carbonic anhydrase (CA) inhibitors, a class of therapeutic agents with relevance in cancer, glaucoma, and neurological disorders. By integrating natural language processing with cheminformatics and structural biology, LLMs enable efficient mining of chemical knowledge, virtual screening, and generation of candidate molecules. https://cassyni-user-files-prod.s3.amazonaws.com/T5DE9kSiPt97zRRHYEX18i https://cassyni.com/events/DgTkfyaADaQwibmgothEoF/seminar/qa https://cassyni.com/slides/outline/DgTkfyaADaQwibmgothEoF https://cassyni.com/events/DgTkfyaADaQwibmgothEoF/abstract https://cassyni-user-files-prod.s3.amazonaws.com/RrZXxsJbwJzbmNcJHWLKt2 https://cassyni.com/events/DgTkfyaADaQwibmgothEoF?videoPreview=1 Women's Health: Shaping the Future of Research and Publishingnohttps://cassyni.com/events/DgTkfyaADaQwibmgothEoF?videoPreview=12026-01-28T15:00:00+00:001783.36Women's HealthPlease join us for an engaging talk that offers a behind-the-scenes look at the journal Women’s Health. We will explore the journal’s scope, article types, peer review process, and the development of ongoing Special Collections. As the editorial team, including Publishing Editor and Commissioning Editor for Special Collections, we will share insights into how themed content is curated and how you can contribute to these focused areas of research. Attendees will come away with practical guidance on preparing a successful submission, understanding editorial expectations, and navigating the publishing process. Whether you're a first-time author or an experienced researcher, this session is designed to support and empower you in sharing your work with a diverse, international audience. "As the Publishing Editor and Commissioning Editor for Special Collections at Women’s Health, we are proud to support authors from all backgrounds in sharing high-quality, impactful research that improves healthcare for women around the world. This webinar is designed to demystify the publishing process, highlight opportunities within our Special Collections, and help you feel confident submitting your work to our journal." - Stephanie Shroot and Shasha Sharief Disclaimer: The information provided herein is current as of 2026 and is intended for general guidance only. Please note that circumstances, regulations, or data may change over time, and as such, the content may become outdated. We make no guarantees regarding the future accuracy or applicability of this information. Always verify with up-to-date sources before making decisions based on this material.https://cassyni-user-files-prod.s3.amazonaws.com/RrZXxsJbwJzbmNcJHWLKt2 https://cassyni.com/slides/outline/ADvXMC3V9NYJguU8AEKHGR https://cassyni.com/events/ADvXMC3V9NYJguU8AEKHGR/abstract https://cassyni-user-files-prod.s3.amazonaws.com/3CgxapVJptMr6VaQ3CKHLJ https://cassyni.com/events/ADvXMC3V9NYJguU8AEKHGR?videoPreview=1 Critical Metascience: Does Metascience Need to Change?nohttps://cassyni.com/events/ADvXMC3V9NYJguU8AEKHGR?videoPreview=12025-06-23T14:00:00+00:008827.0Over the years metascience and associated Open Science reforms have garnered extensive criticism. Moderated by Sven Ulpts (psychology/science studies) and Sheena Bartscherer (social sciences/science studies), in this pre-conference event we would like to provide an open forum for these critical metascience voices by hosting key representatives: Mark Rubin (psychology) will introduce the area of critical metascience and its importance, while Carlos Santana (philosophy of science) will talk about the perils of designing Open Science infrastructures for machine availability and highlight how that can trade off with human epistemic needs. Lisa Malich (history of science/ psychology) will talk about the dangers of Metascience's tendencies to homogenize research, while Lai Ma (information science) will question the assumptions of knowledge as public good and openness as equitable. Thomas Hostler (psychology) will talk about potential alignments of open research reforms with academic capitalism and how this can lead to the exploitation of academic labour. To keep the session dynamic, the audience is invited to give feedback after each talk. Following the talks we'll transition into an open roundtable discussion, to reflect on the kinds of reactions and feedback our panellists have received during the event, but also in the past from the wider metascience community. We will close the event by asking whether these fundamental critiques have had an impact on the culture surrounding metascience, especially concerning reflexivity and how the community engages with criticism. We intend to foster an inclusive discourse culture and to provide an intellectual playground for critical and thought-provoking exchange.https://cassyni-user-files-prod.s3.amazonaws.com/3CgxapVJptMr6VaQ3CKHLJ https://cassyni.com/slides/outline/3Jr4hcz8zxnXC6UYnnkM7j https://cassyni.com/events/3Jr4hcz8zxnXC6UYnnkM7j/abstract https://cassyni-user-files-prod.s3.amazonaws.com/6KXrYMRUHWbHFWxqmcSdVY https://cassyni.com/events/3Jr4hcz8zxnXC6UYnnkM7j?videoPreview=1 Reconstructing paleo-trophic relationships on the Brazilian Romualdo Formation (Early Cretaceous) through mercury analysis in fossilsnohttps://cassyni.com/events/3Jr4hcz8zxnXC6UYnnkM7j?videoPreview=12025-06-05T22:00:00+00:002028.92Frontiers in Earth ScienceMercury (Hg) biomagnification values tend to reflect relationships between species in the trophic web the larger the value, the higher their position in the web. Here we present the first attempt to reconstruct paleo-trophic linkages during the onset of the Romualdo Formation in the Araripe Basin (Northeastern Brazil), based on analyses of Hg concentration ([Hg]) of fossil specimens recorded in this lithological unit. The aim is to understand possible relationships between vertebrate and invertebrate species inhabiting its paleoenvironments during the early "lagoon" phase of its deposition. Observed ratios (log[Hg]Sample) between [Hg] in fossils ([Hg]Fossil) and their surrounding concretions ([Hg]Rock) indicate greater biomagnification with change in feeding habits and size of evaluated vertebrate taxa, being lowest in the small actinopterygian fish genera Rhacolepis and Tharrhias and reaching its peak in the large predators Cladocyclus and Calamopleurus (the apex species of the trophic pyramid). Feeding habits of Vinctifer were also reviewed, and the genus was reinterpreted from filter feeder to mesopredator; Neoproscinetes and an unidentified batoid (Chondrichthyes), two durophagous bottom-feeding taxa, recorded values compatible with their predicted feeding habits. Low log[Hg]Sample ratios were observed in ornithocheiraean pterosaurs (Reptilia), suggesting it a mesopredators specialized in the smaller fish species, while Thalassodrominae presented intermediate to high log[Hg]Sample, pointing out to a unique trophic role as a terrestrial opportunistic generalist, ranging from predator to scavenger.https://cassyni-user-files-prod.s3.amazonaws.com/6KXrYMRUHWbHFWxqmcSdVY https://cassyni.com/events/ChAYacH7LfJo3qwghvDuzM/abstract https://cassyni-user-files-prod.s3.amazonaws.com/XCqHgkwGZE6vMGz1v35pMU https://cassyni.com/events/M6DSUrnvCoeWMezZ4LVQqs/abstract https://cassyni-user-files-prod.s3.amazonaws.com/ELxPWgaaHSR31Hra7Tw9gS https://cassyni.com/events/PZTTiH2YQ6QzibU7c2Q3Zo/seminar/qa https://cassyni.com/slides/outline/PZTTiH2YQ6QzibU7c2Q3Zo https://cassyni.com/events/PZTTiH2YQ6QzibU7c2Q3Zo/abstract https://cassyni-user-files-prod.s3.amazonaws.com/V3wkudcFAWz9R94Yi2CV18 https://cassyni.com/events/PZTTiH2YQ6QzibU7c2Q3Zo?videoPreview=1 Innovative Environmental Solutions towards Green and Sustainable Artificial Intelligencenohttps://cassyni.com/events/PZTTiH2YQ6QzibU7c2Q3Zo?videoPreview=12025-06-26T15:00:00+00:004547.8Environmental Science and EcotechnologyDiscover an insightful webinar hosted by Environmental Science and Ecotechnology that tackles the urgent challenge of making AI environmentally sustainable. Leading experts will delve into critical topics, including the carbon footprint of data centers, the health risks tied to AI's energy demands, and cutting-edge solutions like Health-Informed AI models. This event shines a spotlight on the growing ecological impact of artificial intelligence and offers practical strategies to minimize it. It’s a must-attend for anyone eager to merge technological innovation with sustainability, providing valuable takeaways for a more eco-conscious digital future. Image credit: [Christopher Burns (Unsplash)](https://unsplash.com/photos/white-and-black-digital-wallpaper-Kj2SaNHG-hg).https://cassyni-user-files-prod.s3.amazonaws.com/V3wkudcFAWz9R94Yi2CV18 https://cassyni.com/slides/outline/L6vEPVVsKtYMguAYxN262y https://cassyni.com/events/L6vEPVVsKtYMguAYxN262y/abstract https://cassyni-user-files-prod.s3.amazonaws.com/3WERC9LRXu8WrS3q7kmzQN https://cassyni.com/events/L6vEPVVsKtYMguAYxN262y?videoPreview=1 Spaceport Location Planning in the Continental United Statesnohttps://cassyni.com/events/L6vEPVVsKtYMguAYxN262y?videoPreview=12025-07-01T10:00:00+00:003418.76Department of AeronauticsThe burgeoning commercial space transportation industry necessitates an expansion of launch infrastructure to meet rising demands. To rigorously reason about where such future spaceports might be located and what their impacts might be, we introduce a facility location planning model for future US spaceports (SPFLP). The SPFLP outputs a cost-optimal set of candidate locations for future spaceports while satisfying a range of operational constraints. By conducting sensitivity analyses on the SPFLP, we can examine differences in flight rerouting costs and optimal launch mission allocations. Our model and numerical experiments offer valuable insights for future spaceport site selection, contributing to the strategic development of commercial space transportation while keeping in mind the need to integrate these operations within the US National Airspace System. I will conclude by briefly expanding on other applications of operations research in aerospace engineering, including in sustainable aviation and air traffic management. Joint work with Teja Koduru, Angel Lin, Jackson Miller, Aria Olson, Kevin Sun, Nattanan Wongprapinkul, Haochen Wu, Gökçin Çınar, Oliver Jia-Richards, and Aaron Johnson.https://cassyni-user-files-prod.s3.amazonaws.com/3WERC9LRXu8WrS3q7kmzQN https://cassyni.com/events/UzcjLRfCdVSAfhWXpKU7S5/abstract https://cassyni-user-files-prod.s3.amazonaws.com/9noK3Sg1hwXiq52zxWJy66 https://cassyni.com/slides/outline/4JE98spr5xfweivCafpTP3 https://cassyni.com/events/4JE98spr5xfweivCafpTP3/abstract https://cassyni-user-files-prod.s3.amazonaws.com/43UmgJtGH4SKWar4Pna55p https://cassyni.com/events/4JE98spr5xfweivCafpTP3?videoPreview=1 Skin metatranscriptomics reveals a landscape of variation in microbial activity and gene expression across the human bodynohttps://cassyni.com/events/4JE98spr5xfweivCafpTP3?videoPreview=12025-10-15T02:00:00+00:00644.24Microbiome Virtual International ForumMetatranscriptomics methods for the skin are hampered by low microbial biomass, contamination with host cells, and low RNA stability. We develop a robust, clinically tractable skin metatranscriptomics workflow that provides high technical reproducibility of profiles, uniform coverage across gene bodies, and strong enrichment of microbial mRNAs. Paired application of this protocol with metagenomics to five skin sites in a cohort of 27 healthy adults identifies a notable divergence between transcriptomic and genomic abundances. Specifically, Staphylococcus species and the fungi Malassezia had an outsized contribution to metatranscriptomes at most sites, despite their modest representation in metagenomes. Species-level analysis shows signatures of microbial adaptation to their niches. Gene-level analysis identifies diverse antimicrobial genes transcribed by skin commensals in situ, including several uncharacterized bacteriocins. Correlation of microbial gene expression with organismal abundances uncovers >20 genes that putatively mediate interactions between microbes. This work highlights how skin metatranscriptomics identifies active species and microbial functions in situ.https://cassyni-user-files-prod.s3.amazonaws.com/43UmgJtGH4SKWar4Pna55p https://cassyni.com/slides/outline/LHGdWuveVVreczW3Cxga1 https://cassyni.com/events/LHGdWuveVVreczW3Cxga1/abstract https://cassyni-user-files-prod.s3.amazonaws.com/LifwB26gy2h3ddRgnxiyPC https://cassyni.com/events/ACrs1GToqfLh6LL7bwmqTT/seminar/qa https://cassyni.com/slides/outline/ACrs1GToqfLh6LL7bwmqTT https://cassyni.com/events/ACrs1GToqfLh6LL7bwmqTT/abstract https://cassyni-user-files-prod.s3.amazonaws.com/BXmBBSHJ1MqPmS6R1nQpAJ https://cassyni.com/events/ACrs1GToqfLh6LL7bwmqTT?videoPreview=1 Neuroproteomics as a tool for understanding schizophrenianohttps://cassyni.com/events/ACrs1GToqfLh6LL7bwmqTT?videoPreview=12025-11-26T11:00:00+00:004028.0The Pharmacological Research family of journalsThe combination of liquid chromatography (LC) to mass spectrometry (MS) builds up a powerful tool for identifying and quantifying thousands of proteins in a single sample, providing data to test increasingly complex hypotheses. In the past two decades, both separation science and MS instruments grow in capability, providing higher numbers of identifications and more robust quantitation. Whilst large-scale proteomics has set the tone in discovery important proteins to a given biological context, investigating the biology associated to each of the identified proteins are pivotal for the understanding of biological mechanisms. In addition, it is possible to focus proteomic findings to the discovery of drug targets and the evaluation of therapeutic interventions. During my presentation, I intend explore a proteomic workflow employed to study schizophrenia. Such workflow starts from a standard large-scale proteomic analysis in clinical samples that is narrowed down to a few proteins whose biological function is investigated in more detail in pre-clinical models. Using this, we shed light in the role of glia cells and in the identification of potential biomarkers associated with effective schizophrenia medication. Evolving from the large-scale neuroproteomic analysis to a focused investigation of specific proteins may enable, for instance, potential molecular targets that may become useful for the development of innovative treatments to schizophrenia.https://cassyni-user-files-prod.s3.amazonaws.com/BXmBBSHJ1MqPmS6R1nQpAJ https://cassyni.com/slides/outline/G9jQ22KfpE7CuEhsZFS3S5 https://cassyni.com/events/G9jQ22KfpE7CuEhsZFS3S5/abstract https://cassyni-user-files-prod.s3.amazonaws.com/VVRT46KesxjJ4Hc7J3abTC https://cassyni.com/events/G9jQ22KfpE7CuEhsZFS3S5?videoPreview=1 Scaling Digital Sustainabilitynohttps://cassyni.com/events/G9jQ22KfpE7CuEhsZFS3S5?videoPreview=12022-10-13T23:00:00+00:006790.32Business SchoolThe global imperative of the climate crisis and the rising prominence of Environmental, Social, and Governance (ESG) frameworks underscore the critical role of digital technologies in driving sustainability transformation. This seminar explores how technology can facilitate sustainability initiatives and assesses the current state of digital sustainability, particularly within New Zealand. Drawing on global consulting experience, several case studies demonstrate technology’s application in ESG. Examples include smart reusable cup systems enabling data-driven reuse models, industry-wide collaborations for establishing carbon measurement methodologies in music streaming, and environmental impact assessments for cryptocurrencies, noting Ethereum 2.0's projected 99.9% footprint reduction post-transition to a Proof of Stake model. Complementary academic research, including a survey of 200 large Asia-Pacific companies and two ongoing studies of approximately 100 New Zealand firms, reveals significant regional disparities. New Zealand companies lack "Leaders" in digital sustainability, with most categorized as "Explorers" needing to develop capabilities in partnership, governance, or sustainability orientation. Compared to Australia, New Zealand exhibits less internal alignment between IT and sustainability functions. Investment in sustainability is primarily driven by regulation and customers, with a pronounced preference for social over environmental outcomes. A critical finding is that no New Zealand companies surveyed currently track or set targets for Scope 3 emissions, and 62% are unaware of their service providers' emissions, with 55% indicating they would remove non-reporting IT service providers rather than fostering their development. These findings highlight a significant gap in New Zealand's digital sustainability maturity, particularly in understanding and managing indirect emissions, and call for increased investment in data, consistent measurement methodologies, and collaborative development across the supply chain.https://cassyni-user-files-prod.s3.amazonaws.com/VVRT46KesxjJ4Hc7J3abTC https://cassyni.com/slides/outline/AibkWWCtzC28WNTdxLSFSd https://cassyni.com/events/AibkWWCtzC28WNTdxLSFSd/abstract https://cassyni-user-files-prod.s3.amazonaws.com/8KS1xD8GzRgmi46M91JnPg https://cassyni.com/events/AibkWWCtzC28WNTdxLSFSd?videoPreview=1 Value Creation via Digital Transformationnohttps://cassyni.com/events/AibkWWCtzC28WNTdxLSFSd?videoPreview=12021-11-19T00:00:00+00:001171.76Business SchoolThis presentation explored digital innovation in value creation through two distinct initiatives. The first focused on the rapid deployment of digital solutions during crises, exemplified by SOS BUSINESS, a not-for-profit platform launched in March 2020. This initiative enabled small businesses, such as cafes, to sell vouchers online during COVID-19 lockdowns, providing vital cash flow. The platform, initially a quick build, rapidly scaled to serve over 2,800 businesses, ultimately generating approximately $3 million in revenue through numerous small transactions. This required migrating to a custom-configured Shopify e-commerce system and developing robust fraud detection processes, highlighting the critical role of speed and adaptability in digital transformation under pressure. The second part of the presentation addressed systemic challenges within the New Zealand technology sector, which employs 110,000 people and contributes $13.9 billion in exports, representing 8% of the national GDP. Despite this significant growth, the sector faces considerable issues with diversity and inclusion: women constitute only 27% of the IT workforce, Māori 4%, and Pasifika less than 3%. This is compounded by a disproportionate decline in tertiary IT graduates from these underrepresented groups, exacerbating talent shortages. In response, the Hi-Tech Trust has established an endowment fund to foster equitable participation. This fund provides scholarships addressing barriers like childcare and transport costs, supports first-generation university students, and invests in grassroots programs, such as teaching computer programming skills in prisons, to create broader opportunities and ensure long-term talent development.https://cassyni-user-files-prod.s3.amazonaws.com/8KS1xD8GzRgmi46M91JnPg https://cassyni.com/events/MatfeAxL3d8LB7z4rScP25/abstract https://cassyni-user-files-prod.s3.amazonaws.com/4XNu86pV5uFuUcFGToAATp https://cassyni.com/slides/outline/LbbTYofHAi2BWNA4kU94DB https://cassyni.com/events/LbbTYofHAi2BWNA4kU94DB/abstract https://cassyni-user-files-prod.s3.amazonaws.com/XwLHEo7Cp5aC6CDHmpeYPG https://cassyni.com/events/LbbTYofHAi2BWNA4kU94DB?videoPreview=1 Thermodynamic paradoxes and topological singularities in fluctuation-induced fieldsnohttps://cassyni.com/events/LbbTYofHAi2BWNA4kU94DB?videoPreview=12025-06-17T05:00:00+00:001837.0ETOPIMThe analysis addresses thermodynamic paradoxes arising in non-reciprocal systems supporting fluctuation-induced electromagnetic fields, particularly focusing on thermal energy transport in topological and unidirectional waveguides. Starting from Nyquist–Johnson theory and the fluctuation–dissipation theorem, the study examines how thermal noise currents generate electromagnetic energy flows characterized by the Poynting vector. While reciprocal systems exhibit zero net thermal energy flow at equilibrium, non-reciprocal systems can sustain circulating energy currents with zero divergence, leading to closed orbits of energy flow. A paradox emerges in unidirectional waveguides with localized dissipation only at one end: thermal energy generated cannot be absorbed or returned, implying an unphysical accumulation of energy and violation of equilibrium. Quasi-static approximations reveal singular field behavior at critical points, with finite stored energy only ensured by including material loss. However, even with loss distributed throughout the system, the paradox persists due to the bi-orthogonal modal expansion involving both lossy and gain-like modes, producing unavoidable singularities in the Green’s function and Poynting vector. The resolution is found by incorporating spatial dispersion effects, which arise naturally from the microscopic granularity of ferrite materials and prevent field localization. This nonlocal response introduces additional counter-propagating modes, restoring bidirectionality and eliminating singularities. Crucially, the presence of spatial dispersion renders the system topological, enforcing bulk-edge correspondence that balances inward and outward modes and forbids energy sinks. Thus, topological protection emerges as a fundamental mechanism preventing thermodynamic paradoxes in fluctuation-induced fields within non-reciprocal media.https://cassyni-user-files-prod.s3.amazonaws.com/XwLHEo7Cp5aC6CDHmpeYPG https://cassyni.com/slides/outline/XTrkZqtppnCf2dz6N1NkA1 https://cassyni.com/events/XTrkZqtppnCf2dz6N1NkA1/abstract https://cassyni-user-files-prod.s3.amazonaws.com/BhZZHhoarJFTCQRC7qxpkn https://cassyni.com/events/XTrkZqtppnCf2dz6N1NkA1?videoPreview=1 Gyrotropic metamaterials with tailored magnetizationnohttps://cassyni.com/events/XTrkZqtppnCf2dz6N1NkA1?videoPreview=12025-06-19T23:00:00+00:002291.16ETOPIMMagnetic materials play a crucial role in nonreciprocal electromagnetic devices, such as Faraday rotators, isolators, circulators, and nonreciprocal phase shifters. However, their use is often limited by the need for a uniform bias magnetic field and nonuniform demagnetizing fields. This results in the restricted aperture of free-space devices, poor temperature stability, and incompatibility with magnetic field-sensitive applications. Alternative methods have been developed to achieve nonreciprocity using active, nonlinear, and time-varying metamaterials, each with its own advantages and limitations. Here, we present a new approach1 based on self-biased gyrotropic metamaterials composed of magnetically hard magnets embedded in a magnetically soft ferrite matrix. In this configuration, the hard magnets provide the magnetic bias for the soft ferrite matrix, which produces a nonreciprocal response. This gyrotropic metamaterial can exhibit zero net magnetization (ZNM) while producing strong and uniform Faraday rotation over a broad temperature range. Without bias and demagnetizing fields, the aperture of this Faraday rotator can be virtually unlimited. Using this method, we demonstrate uniform 45-degree Faraday rotation and effective isolation across the microwave X-band. Figure 1 presents the magnetic and MW properties of a gyrotropic metamaterial featuring ZNM. This ZNM metamaterial consists of a hexagonal array of NdFeB micromagnets embedded in a planar YIG matrix. The ferrite's thickness is tuned to achieve a 45-degree Faraday rotation at 10 GHz. Figure 1a shows the zcomponent of the magnetic field He produced by the NdFeB micromagnets without the ferrite. The field He is highly uniform throughout the array and strong enough to magnetize the ferrite matrix to its saturation point. As expected for ZNM metamaterials, the internal field He is zero both inside and outside the composite, except near the poles of the micromagnets (Fig. 1b). When the ZNM metamaterial is sandwiched between two impedance-matching layers, it produces a 45-degree Faraday rotation and a slight ellipticity, as demonstrated in Fig. 1c. This Faraday rotator achieves isolation exceeding 40 dB and insertion loss below 0.5 dB within the frequency range of 9 to 11.5 GHz (Fig. 1d)https://cassyni-user-files-prod.s3.amazonaws.com/BhZZHhoarJFTCQRC7qxpkn https://cassyni.com/slides/outline/7G69JMC7KM4krxEFSE5Sjf https://cassyni.com/events/7G69JMC7KM4krxEFSE5Sjf/abstract https://cassyni-user-files-prod.s3.amazonaws.com/X3HotKvkhpKy6JGPuocYBg https://cassyni.com/events/7G69JMC7KM4krxEFSE5Sjf?videoPreview=1 From data to diversity: exploring Australia’s AM fungal communities through AusAMFnohttps://cassyni.com/events/7G69JMC7KM4krxEFSE5Sjf?videoPreview=12025-07-10T12:00:00+00:001062.04NoneArbuscular mycorrhizal (AM) fungi are important for plant nutrition, soil function, and terrestrial resilience. Despite the important advances made in our understanding of their diversity and distribution, we still lack a coherent picture of their diversity and distribution. Nowhere is this more apparent than in Australia: a continent of ecological singularity, vast heterogeneity, and profound evolutionary isolation, yet until recently, a conspicuous blank spot on the mycorrhizal map. The newly established AusAMF database begins to address this disparity, drawing together AM fungal community data from over 600 georeferenced sites spanning all major Australian biomes, collected via standardised protocols for soil storage, DNA extraction, and sequencing. This unprecedented dataset permits spatially explicit inferences about AM fungal biogeography, hints at the imprint of dispersal limitation, and lays the groundwork for disentangling environmental and evolutionary drivers of community assembly. The data highlight a striking spatial structuring and suggest new lines of inquiry into context-dependent diversity, phylogenetic composition, and functional biogeography. AusAMF represents a platform for hypothesis generation—a scaffold for advancing both regional and global understanding of these ancient and essential symbionts. With additional sampling underway, this expanding dataset promises further insights yet to be analysed, interpreted, and integrated into the broader story of mycorrhizal biogeography. https://cassyni-user-files-prod.s3.amazonaws.com/X3HotKvkhpKy6JGPuocYBg https://cassyni.com/slides/outline/Cg6tEghS2x7BTGog9dgUBP https://cassyni.com/events/Cg6tEghS2x7BTGog9dgUBP/abstract https://cassyni-user-files-prod.s3.amazonaws.com/MwjZYgqd7g15i3aBRqPgSA https://cassyni.com/events/Cg6tEghS2x7BTGog9dgUBP?videoPreview=1 An online panel about problem-based (distance) learning with the Reflect! platformnohttps://cassyni.com/events/Cg6tEghS2x7BTGog9dgUBP?videoPreview=12020-04-28T08:00:00+00:002979.84 School of Public PolicyNo abstracthttps://cassyni-user-files-prod.s3.amazonaws.com/MwjZYgqd7g15i3aBRqPgSA https://cassyni.com/slides/outline/AhY6AadDgUpWuoKdQ3todf https://cassyni.com/events/AhY6AadDgUpWuoKdQ3todf/abstract https://cassyni-user-files-prod.s3.amazonaws.com/YQ9inNhTeQsa7sgKr1L4xe https://cassyni.com/events/AhY6AadDgUpWuoKdQ3todf?videoPreview=1 Rocks, Fluids, and Life: Microbes in Earth's Deep Ocean and Beyondnohttps://cassyni.com/events/AhY6AadDgUpWuoKdQ3todf?videoPreview=12026-06-02T01:00:00+00:002477.72Microbiome Virtual International ForumThe deep ocean’s rocky crust, covering 70% of Earth and accounting for 75% of its volcanic activity, hosts a vast and largely uncharacterized microbial biosphere crucial for global biogeochemical cycles. This subseafloor environment functions as a giant aquifer, trapping 2% of global ocean volume and providing a substantial habitable space sustained by constant water-rock reactions. Microbial life is investigated through sampling naturally leaking crustal fluids, next-generation sequencing, RNA stable isotope probing, NanoSIMS, eukaryotic grazing experiments, and viral analyses. Hydrothermal vents exhibit microbial cell concentrations up to 100,000 cells/mL. These communities are phylogenetically and functionally diverse, displaying high microdiversity and functional redundancy. Hydrogenotrophic methanogens (Archaea), capable of growth up to 122 °C, are significant primary producers, fixing inorganic carbon and cycling H2, Fe, CH4, S, and N. Eukaryotic grazing activity is notably higher than in surrounding seawater, with microbial eukaryotes showing endemism. Viral populations (DNA viruses) are also diverse and endemic, characterized by a narrow host range and high specialization. Older, non-volcanic ridge flanks (3.5-23 million years old), such as the North Pond system, support low-biomass (~1,000 cells/mL) but active, motile microbial communities. These are primarily heterotrophic, consuming organic carbon, and NanoSIMS experiments reveal a wide range of single-cell carbon uptake rates, indicating metabolic readiness. This deep-sea life provides essential ecosystem services, including genetic resources for drug discovery, novel chemical compounds, and critical roles in carbon and nutrient cycling. As human activities increasingly impact the deep ocean, understanding these services is vital for responsible stewardship. Furthermore, the discovery of robust deep-sea ecosystems informs the search for extraterrestrial life, particularly on ocean worlds like Enceladus, where detected chemical signatures (hydrogen, CO2, methane) suggest potential low-temperature hydrothermal systems analogous to Earth's.https://cassyni-user-files-prod.s3.amazonaws.com/YQ9inNhTeQsa7sgKr1L4xe https://cassyni.com/events/J7HmyTqyfi45ZA8LcLJJuT/seminar/qa https://cassyni.com/slides/outline/J7HmyTqyfi45ZA8LcLJJuT https://cassyni.com/events/J7HmyTqyfi45ZA8LcLJJuT/abstract https://cassyni-user-files-prod.s3.amazonaws.com/JGgeujLZU7nxeoXyWgwdjC https://cassyni.com/events/J7HmyTqyfi45ZA8LcLJJuT?videoPreview=1 Thieme Cheminar: Rising Stars in Organic Chemistry, Session 5nohttps://cassyni.com/events/J7HmyTqyfi45ZA8LcLJJuT?videoPreview=12025-11-19T08:00:00+00:006889.16Thieme GroupThe Science of Synthesis Early Career Board (ECAB), established in 2022, recognizes some of the most up-and-coming young organic chemists. We are very proud to present ECAB members of the 2025 board as speakers in this Rising Stars Cheminar. In this Thieme Cheminar, Science of Synthesis Early Career Advisory Board members Emma Davison (New Zealand), Chuan He (China), Tomohiro Hattori (Japan), Hyunwoo Kim (South Korea), Xiao-Hui Yang (China), and Durga Prasad Hari (India) will present their research. The session is chaired by Shu Kobayashi (Japan).https://cassyni-user-files-prod.s3.amazonaws.com/JGgeujLZU7nxeoXyWgwdjC https://cassyni.com/slides/outline/DfQ6L3zUusDL82dgFc9nzH https://cassyni.com/events/DfQ6L3zUusDL82dgFc9nzH/abstract https://cassyni-user-files-prod.s3.amazonaws.com/JnBDvpss4jSup24tUwfdEn https://cassyni.com/events/DfQ6L3zUusDL82dgFc9nzH?videoPreview=1 Two approaches for mitigating global climate changenohttps://cassyni.com/events/DfQ6L3zUusDL82dgFc9nzH?videoPreview=12020-10-22T08:00:00+00:004349.68 School of Public PolicyThis seminar presents two distinct approaches to mitigating global climate change: Solar Radiation Management (SRM) via stratospheric sulfur geoengineering and greenhouse gas emissions reductions through targeted policy and technology deployment. The analysis of SRM focuses on the deliberate injection of sulfur dioxide (SO2) aerosols into the stratosphere to reflect sunlight and reduce surface temperatures, inspired by volcanic eruption analogs such as Mount Pinatubo. Climate model intercomparison projects (GeoMIP) simulate scenarios with varying SO2 injection rates, revealing that while SRM can effectively lower global temperatures, it induces regional precipitation changes—particularly reductions in summer monsoon rainfall over India and China—and risks rapid warming upon abrupt termination. Additional concerns include stratospheric ozone depletion, acid rain, ecosystem disruption, and governance challenges related to setting planetary temperature targets and managing complex intervention systems. Cost estimates suggest SRM could be implemented at billions of dollars annually, cheaper than comprehensive energy system transformation, but indirect risks remain substantial. In contrast, the emissions reduction approach emphasizes subnational implementation, exemplified by the Drawdown Georgia Project, which adapts global carbon mitigation frameworks to state-level contexts. This methodology prioritizes 20 high-impact, cost-competitive solutions—ranging from rooftop solar expansion and energy-efficient transportation to land-use practices—selected through stakeholder engagement and technical feasibility criteria. Modeling indicates achievable scenarios could reduce Georgia’s carbon footprint by 35% by 2030, with potential for net-negative emissions under maximum technical deployment. Economic analysis highlights that many solutions, such as rooftop solar and reduced food waste, offer net cost savings alongside health co-benefits from reduced air pollution. The integration of interactive tools enables stakeholders to explore emissions reduction pathways tailored to local conditions. Together, these approaches underscore the complexity of climate mitigation, balancing rapid symptom management via geoengineering with systemic decarbonization strategies that address root causes and co-benefits.https://cassyni-user-files-prod.s3.amazonaws.com/JnBDvpss4jSup24tUwfdEn https://cassyni.com/slides/outline/M59n8wDEu6Stm5rYW3wy2u https://cassyni.com/events/M59n8wDEu6Stm5rYW3wy2u/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Cb7nTuGKv8Bd3aBnq2JohY https://cassyni.com/events/M59n8wDEu6Stm5rYW3wy2u?videoPreview=1 Meeting the Moment: Supporting the Use of AI in Medical Educationnohttps://cassyni.com/events/M59n8wDEu6Stm5rYW3wy2u?videoPreview=12025-02-27T09:00:00+00:003542.76AAMCThe speakers introduce two new resources: the [Principles for the Responsible Use of AI in and for Medical Education](https://www.aamc.org/about-us/mission-areas/medical-education/principles-ai-use) and the International Advisory Committee on AI's [2025 Vision and Integration Frameworks](https://www.medbiq.org/initiatives/international-advisory-committee-artificial-intelligence). This webinar is part of the Artificial Intelligence in Academic Medicine Webinar Series, hosted by the AAMC. It explores critical concepts, the current landscape, and practical strategies drawn from various perspectives and institutions to support you in navigating the evolving world of AI in academic medicine. For more information, see [the complete series webpage](https://www.aamc.org/about-us/mission-areas/medical-education/artificial-intelligence-ai-academic-medicine-webinar-series). https://cassyni-user-files-prod.s3.amazonaws.com/Cb7nTuGKv8Bd3aBnq2JohY https://cassyni.com/events/PYPoNMSs6PDP82L73jrbkq/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Ja7vLhzvvyAHhxmgHftSqc https://cassyni.com/events/PYPoNMSs6PDP82L73jrbkq?videoPreview=1 Milton Mueller on the UN Digital Compactnohttps://cassyni.com/events/PYPoNMSs6PDP82L73jrbkq?videoPreview=12024-12-06T09:00:00+00:001565.36 School of Public PolicyAbstract not yet added.https://cassyni-user-files-prod.s3.amazonaws.com/Ja7vLhzvvyAHhxmgHftSqc https://cassyni.com/slides/outline/L5ra3ZvC2BLk6L2YQ5UeE1 https://cassyni.com/events/L5ra3ZvC2BLk6L2YQ5UeE1/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Bwc4zXGSagJiN7RvThNCWz https://cassyni.com/events/L5ra3ZvC2BLk6L2YQ5UeE1?videoPreview=1 21st Century Liberal Artsnohttps://cassyni.com/events/L5ra3ZvC2BLk6L2YQ5UeE1?videoPreview=12016-12-02T09:00:00+00:006144.12 School of Public PolicyThe seminar explores the distinctive character and evolving role of liberal arts education at a technological university, specifically Georgia Tech, in the 21st century. Emphasizing interdisciplinarity, problem-focus, and innovation, the liberal arts at Georgia Tech integrate humanities and social sciences with science and technology to address complex global challenges. The discussion highlights diverse disciplinary perspectives from public policy, economics, history and sociology, modern languages, and international affairs, illustrating how each contributes uniquely to a human-centered, technologically informed liberal arts framework. Key themes include the necessity of bridging disciplinary boundaries through co-disciplinary collaboration, the cultivation of critical thinking and cultural competence, and the importance of addressing contemporary issues such as climate change, privacy, global citizenship, and social justice. Challenges identified include declining investment in humanities, the compartmentalization of disciplines, and the difficulty of engaging students who often prioritize technical majors. The seminar underscores the liberal arts’ role in fostering broad-minded tolerance, ethical reasoning, and the capacity to pose open-ended questions amid uncertainty. Contributions from allied colleges emphasize shared commitments to public good, cultural understanding, and integrative education. The dialogue concludes with a call for renewed efforts to embed liberal arts sensibilities across curricula, enhance student engagement beyond mere requirements, and develop inclusive frameworks that reconcile multiculturalism with societal cohesion. This integrated approach positions liberal arts as essential to preparing students for leadership in a complex, interconnected world shaped by technological innovation.https://cassyni-user-files-prod.s3.amazonaws.com/Bwc4zXGSagJiN7RvThNCWz https://cassyni.com/events/TzFru8nUSs8QQg8N7u4g3P/seminar/qa https://cassyni.com/slides/outline/TzFru8nUSs8QQg8N7u4g3P https://cassyni.com/events/TzFru8nUSs8QQg8N7u4g3P/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Bw6KKS1KmQzZ4pmpgb8xoY https://cassyni.com/events/TzFru8nUSs8QQg8N7u4g3P?videoPreview=1 The dispersion of harmonic generation in a nonlinear wavenohttps://cassyni.com/events/TzFru8nUSs8QQg8N7u4g3P?videoPreview=12026-03-31T13:00:00+00:003550.08MetaMATWave motion lies at the heart of many disciplines in the physical sciences and engineering. For example, problems and applications involving light, sound, heat, or fluid flow are all likely to involve wave dynamics at some level. While the theory of linear waves is fairly established, nonlinear wave motion remains a complex, often mysterious, object—particularly when the nonlinearity is strong. For example, an unbalanced nonlinear wave distorts acutely as it travels and appears to ultimately fully lose its original shape, and in many instances the final outcome is onset of a form of instability. Inherent to this distortion is an intricate mechanism of harmonic generation manifesting in intensive time-varying exchange of energy between the harmonics that matches the wave’s ongoing nonlinear evolution in space and time. In this work, a general theory is presented for the dispersion of these generated harmonics as they emerge and develop in a traveling nonlinear wave. The harmonics dispersion relation−derived by the theory−provides direct and exact analytical prediction of the collective harmonics spectrum in the frequency-wavenumber domain, and does so without prior knowledge of the spatial-temporal solution. Despite its time-independence, the new relation is shown to be applicable at any temporal state of evolution of the nonlinear wave as long as the wave is balanced or has not yet reached its breaking point. The theory is applied to nonlinear elastic waves in a homogeneous rod and an extension is demonstrated to rods with a periodic array of property modulation (phononic crystal) or intrinsic resonators (elastic metamaterial). Finally, the theory is shown to provide a rigorous explanation of the foundational mechanisms of solitary waves. https://cassyni-user-files-prod.s3.amazonaws.com/Bw6KKS1KmQzZ4pmpgb8xoY https://cassyni.com/events/EA6wbzfnA3cvmVffDDiGJZ/seminar/qa https://cassyni.com/slides/outline/EA6wbzfnA3cvmVffDDiGJZ https://cassyni.com/events/EA6wbzfnA3cvmVffDDiGJZ/abstract https://cassyni-user-files-prod.s3.amazonaws.com/FUY9mzWKae3nhtvwizWzyt https://cassyni.com/events/EA6wbzfnA3cvmVffDDiGJZ?videoPreview=1 Presentation of EAJ Issue 15/2 - November 3rdnohttps://cassyni.com/events/EA6wbzfnA3cvmVffDDiGJZ?videoPreview=12025-11-03T16:00:00+00:003128.32European Actuarial JournalEhm et al. (2016) defined forecast dominance, or Bregman dominance as dominance for every Bregman loss function. This letter explores Bregman dominance to compare competing candidate pure premiums. An actuarial interpretation is given for the expectation of extremal consistent loss functions characterizing Bregman dominance, showing their relevance in the context of insurance pricing. An effective testing procedure for Bregman dominance is proposed based on Murphy diagrams and its performance is evaluated through a simulation study. Compared to the existing literature, the proposed testing procedure is easier because it exploits the independence and homogeneity assumptions made in insurance studies and focuses on the conditional mean. An application to a Swiss motor insurance data set demonstrates the potential of the proposed procedure. This article introduces an equity-LIBOR Market Model (LMM) that integrates the investment strategy into the valuation process of participating life insurance policies. Within this framework, we consider bond portfolios rebalanced across multiple maturities and provide a semi-analytical formula for approximating the fair value of liabilities. We then investigate the impact of the investment policy on the net asset value and the Solvency Capital Requirement. To carry out this analysis, we propose a Monte Carlo method for generating sample paths under both LIBOR and real measures, alongside an estimation procedure under the real measure. The numerical illustration focuses on the asset-liability management of an endowment and a life annuity. We introduce and provide evidence to support the Proportionality Hypothesis which states that Covid-19 infection fatality rates are approximately proportional to all-cause death rates by age and subgroup (e.g., socio-economic class). We also show that vaccination played a very significant role in preventing people infected with Covid-19 from needing to be hospitalised, since it reduced the average severity of an infection. Death rates involving Covid-19 were very significantly lower for people in the fully vaccinated group compared to the unvaccinated group. During the pandemic, death rates from other causes were in some cases reduced (e.g., flu and pneumonia), in some cases unchanged (e.g., lung cancer) and in some cases elevated (e.g., heart disease). We discuss the implications of our findings both for potential adjustments to extrapolative mortality models which allow for future pandemics in a way that is consistent with the Proportionality Hypothesis and for insurance companies in terms of both modelling extreme scenarios and the design of mortality catastrophe bonds. This paper tackles the problem of approximating the distribution of future biometric indices under a cohort-based perspective. Unlike period-based evaluations, cohort-based schemes require the computation of conditional expectations for which explicit solutions often do not exist. To overcome this issue, we suggest the application of a well-established methodology, i.e., the Least-Squares Monte Carlo approach. The idea is to approximate conditional expectations by combining simulations and regression techniques, thus avoiding a straightforward but computationally demanding nested simulations method. To show the extreme flexibility and generality of the proposal, we provide extensive numerical results concerning two main longevity indices, life expectancy and lifespan disparity, obtained by adopting both single- and multi-population mortality models. Comparisons between period- and cohort-based results are made as well. Finally, the paper shows that the proposed methodology can be used to approximate other biometric indices at future dates for which cohort-based estimations are often replaced by period ones for computational simplicity. Subjective survival probabilities reflect individuals’ views about own future survival and they vary based on socio-demographic factors. Actuaries and demographers use parametric survival models, often calibrated on population mortality data, to capture and interpret mortality trends. Recent research highlights the importance of considering subjective survival beliefs in mortality studies. In the same spirit, this work aims to evaluate the applicability of subjective survival probabilities in insurance pricing. More specifically, the proposed methodology focuses on the construction of subjective survival tables for pricing insurance products based on various parametric modelling approaches. Our results indicate that subjective survival probabilities contain information useful for predicting actual mortality and pricing life insurance products for the U.S. population.https://cassyni-user-files-prod.s3.amazonaws.com/FUY9mzWKae3nhtvwizWzyt https://cassyni.com/events/Jby18n1PWXXuNd7rQSRH5f/abstract https://cassyni-user-files-prod.s3.amazonaws.com/GbALzZWGUhxFe7HouHvUCE https://cassyni.com/slides/outline/Wx7s4c9jgFXDcbra1ciLAq https://cassyni.com/events/Wx7s4c9jgFXDcbra1ciLAq/abstract https://cassyni-user-files-prod.s3.amazonaws.com/SSz3gqtvbySpaTzSq8GmT4 https://cassyni.com/events/Wx7s4c9jgFXDcbra1ciLAq?videoPreview=1 Academic Entrepreneurship as a Psycho-social Phenomena; Oppertunities in Practice and Researchnohttps://cassyni.com/events/Wx7s4c9jgFXDcbra1ciLAq?videoPreview=12025-08-04T08:00:00+00:004173.0 School of Public PolicyThis seminar examines academic entrepreneurship as a psycho-social phenomenon, emphasizing the interplay between individual identity development and institutional innovation practices. Traditional technology transfer models, often linear and patent-centric, inadequately capture the complex, non-linear processes by which scientific knowledge translates into societal impact. The analysis draws on a multidisciplinary approach combining economic perspectives with social psychology, particularly focusing on identity formation among graduate students and postdoctoral researchers. Empirical insights reveal that approximately 90% of postdocs do not secure academic positions, leading to existential crises and identity exits that result in significant personal and innovation losses. Programs such as the I-Corps customer discovery initiative illustrate how short-term entrepreneurial experiences can reshape identity and improve engagement with innovation resources, though challenges remain in providing adequate mentoring and career guidance. Case studies from DARPA Grand Challenges highlight how diverse, low-resource teams without formal robotics or entrepreneurship backgrounds successfully innovated by leveraging academic knowledge and experimental play, underscoring the importance of team dynamics and iterative learning. The findings suggest that universities should reconceptualize postdoctoral roles as innovation fellowships that integrate research, teaching, and technology transfer missions, supported by diversified mentoring networks spanning academia, government, and industry. This integrated framework aims to better align career realities with innovation outcomes, fostering sustainable academic entrepreneurship and enhancing the social impact of scientific expertise.https://cassyni-user-files-prod.s3.amazonaws.com/SSz3gqtvbySpaTzSq8GmT4 https://cassyni.com/slides/outline/RWzDZ62xrDS9DjcLQhiYBP https://cassyni.com/events/RWzDZ62xrDS9DjcLQhiYBP/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Mf7heimBsMmQBovBW8CTav https://cassyni.com/events/RWzDZ62xrDS9DjcLQhiYBP?videoPreview=1 The Political Economy of Data as an Input to AI Applicationsnohttps://cassyni.com/events/RWzDZ62xrDS9DjcLQhiYBP?videoPreview=12024-10-18T08:00:00+00:006795.76 School of Public PolicyThis seminar examines the political economy of data as a critical input to artificial intelligence (AI) applications, focusing on the emergent phenomenon of data enclosure and its governance implications. Data enclosure describes the process by which user-generated data, once openly accessible, becomes increasingly restricted through technological and contractual mechanisms controlled by platform providers. This shift impacts privacy, competition, and data governance in multi-sided digital markets, particularly amid the commercialization of generative AI. Analysis of leading large language models reveals variations in dataset sizes and sourcing strategies, highlighting that data quantity alone does not determine model performance; qualitative differences in data curation and use are equally significant. Emerging technical protocols, such as the Text and Data Mining (TDM) reservation and Robots Exclusion Protocols, aim to enable rights holders to signal preferences regarding data use, though their adoption and enforcement remain limited. Contractual agreements between data suppliers and AI developers are proliferating, with multiple non-exclusive licenses reflecting the growing market value of curated data. The seminar also explores market-based governance through APIs and intermediary platforms that facilitate data access, security, and monetization. A case study of India’s data sovereignty approach illustrates a state-centric strategy combining data localization, accumulation, and market creation to assert control over data assets, motivated by economic and national security concerns. The Indian model underscores tensions between territorial data control and the need for global collaboration to ensure data quality and effective AI governance. Overall, the analysis highlights the complex interplay of technological, legal, and economic factors shaping data governance in AI’s evolving landscape.https://cassyni-user-files-prod.s3.amazonaws.com/Mf7heimBsMmQBovBW8CTav https://cassyni.com/slides/outline/6FhekRoVjMqGT9ZqVQ8EVB https://cassyni.com/events/6FhekRoVjMqGT9ZqVQ8EVB/abstract https://cassyni-user-files-prod.s3.amazonaws.com/BkhKZWQ4Ybys9rhdmHENU6 https://cassyni.com/events/6FhekRoVjMqGT9ZqVQ8EVB?videoPreview=1 Intelligent Design in the Classroom?nohttps://cassyni.com/events/6FhekRoVjMqGT9ZqVQ8EVB?videoPreview=12006-11-28T09:00:00+00:005161.88 School of Public PolicyThe ongoing controversy surrounding the teaching of evolution in U.S. public school biology classrooms reflects deep cultural, religious, and legal tensions. Evolution challenges traditional worldviews by contradicting certain creationist beliefs about the age of the Earth and the purpose of life, raising questions about the relationship between science and religion and provoking concerns about teleology and social policy misapplications. Historically, anti-evolution laws, such as those upheld in the early 20th century, prohibited teaching evolution, culminating in landmark legal battles like the Scopes Trial. Subsequent balanced treatment acts mandated teaching creationism alongside evolution but were ultimately ruled unconstitutional by the U.S. Supreme Court in 1987, which emphasized criteria distinguishing science from religion, including falsifiability and reliance on natural laws. Despite legal setbacks, challenges persist through measures like textbook disclaimers and ambiguous “alternatives to evolution” policies, which allow teachers discretion to present critiques of evolution without explicitly endorsing creationism. The Intelligent Design movement has emerged as a more nuanced rival, accepting much of evolutionary theory while arguing that certain complex biological features (e.g., the human eye) cannot be explained solely by gradual evolutionary processes, invoking concepts such as irreducible complexity. However, Intelligent Design lacks a unified positive framework and remains contested regarding its scientific rigor and compatibility with common descent. The debate continues over whether such views should be included in biology curricula or relegated to separate classes on ethics or philosophy, with legal and educational implications hinging on the secular intent and scientific status of these perspectives.https://cassyni-user-files-prod.s3.amazonaws.com/BkhKZWQ4Ybys9rhdmHENU6 https://cassyni.com/slides/outline/3nTdX1ZsY54jQzL42cKsUy https://cassyni.com/events/3nTdX1ZsY54jQzL42cKsUy/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Ks1N4mqMWYCcCMhVR496oG https://cassyni.com/events/3nTdX1ZsY54jQzL42cKsUy?videoPreview=1 Fueling the emerging fusion industry: fusion fuel cycle modeling and tritium breeder blanket technology development at the MIT PSFCnohttps://cassyni.com/events/3nTdX1ZsY54jQzL42cKsUy?videoPreview=12024-05-02T06:00:00+00:002770.72Journal of Plasma PhysicsDecades of global work on fusion technology and plasma physics, coupled with a burgeoning private fusion industry, have led to a renewed optimism in the potential of magnetically confined, deuterium-tritium (DT) fueled fusion power plants (FPP). However, to unlock this potential, we must rapidly accelerate development of tritium breeding blanket technology. Due to the scarcity of tritium, it is imperative that DT-fueled FPPs breed their own tritium in lithium-containing blankets that surround the plasma. The first part of the talk will discuss the broad challenges associated with developing breeder blankets and fuel cycle systems capable of attaining tritium self-sufficiency in an FPP, as identified by the recently culminated U.S. Fusion Fuel Cycles and Breeding Blankets workshop and roadmapping process. These challenges are heightened by the fact that experimental data regarding tritium production and extraction in breeder materials is very limited, but the development timelines of private companies are quite accelerated. The second part of the talk will focus on recent results from the tritium breeding research program at the MIT Plasma Science and Fusion Center. First, I will discuss our efforts to build improved models for understanding the tritium needs of a given FPP design, including updated definitions of tritium burn efficiency and more accurate methods of incorporating tritium loss mechanisms. These models help us understand key performance targets for an FPP, predict on-site inventory, and determine whether a given design is likely to be able to sustain sufficient levels of tritium production to ensure its continued operation and the eventual startup of new plants. Second, I will provide an overview of the MIT LIBRA project, which aims to demonstrate global measurements of tritium breeding ratios approaching 1 in molten FLiBe salt exposed to a 14 MeV neutron environment. I will present the key advantages and drawbacks of a molten-salt liquid immersion breeding blanket, present results from our most recent tritium breeding campaigns, and discuss the practical experimental challenges - both past and ongoing - that the LIBRA project team is tackling as we carry out this work.https://cassyni-user-files-prod.s3.amazonaws.com/Ks1N4mqMWYCcCMhVR496oG https://cassyni.com/slides/outline/G8fjg6jzWWubJfZrzxtbd7 https://cassyni.com/events/G8fjg6jzWWubJfZrzxtbd7/abstract https://cassyni-user-files-prod.s3.amazonaws.com/KrjdbeuDsucNEdyDuq38Ht https://cassyni.com/events/G8fjg6jzWWubJfZrzxtbd7?videoPreview=1 From planetary interiors to harnessing star power: exploring the frontier matter at extreme conditions.nohttps://cassyni.com/events/G8fjg6jzWWubJfZrzxtbd7?videoPreview=12024-02-29T06:00:00+00:003321.32Journal of Plasma PhysicsThe study of matter under extreme conditions is a highly interdisciplinary subject with broad applications to materials science, plasma physics, geophysics and astrophysics. Understanding the processes which dictate physical properties in warm dense plasmas and condensed matter, requires studies at the relevant length-scales (e.g., interatomic spacing) and time-scales (e.g., phonon period). Experiments performed at XFEL lightsources across the world, combined with dynamic compression, provide ever-improving spatial- and temporal-fidelity to push the frontier. This talk will cover a very broad range of conditions, intended to present an overview of important recent developments in how we generate extreme environments and then how we characterize and probe matter at extremes conditions– providing an atom-eye view of transformations and the fundamental physics dictating plasma and materials properties. Examples of case-studies closely related to planetary sciences and inertial fusion energy, as enabled by ultrafast X-ray imaging, diffraction and spectroscopy, will be discussed.https://cassyni-user-files-prod.s3.amazonaws.com/KrjdbeuDsucNEdyDuq38Ht https://cassyni.com/slides/outline/BCBhDGGk7wNZuZrWzVBbty https://cassyni.com/events/BCBhDGGk7wNZuZrWzVBbty/abstract https://cassyni-user-files-prod.s3.amazonaws.com/2YFX3dJf7G2pK64DwGASRL https://cassyni.com/events/BCBhDGGk7wNZuZrWzVBbty?videoPreview=1 Biophysics in Africa: Modelling the covalent intermediates of the nitrilase superfamilynohttps://cassyni.com/events/BCBhDGGk7wNZuZrWzVBbty?videoPreview=12024-02-28T06:00:00+00:002478.32Springer Nature Physics CommunityThe nitrilase superfamily, which includes amidases, are thiol enzymes that catalyze the hydrolysis and condensation of non-peptide, carbon-nitrogen linkages. The mechanism of action of these enzymes remains unknown – but substantial insight has been gained from our studies of the closely related amidases. All the enzymes have a structurally conserved active site grouping comprising two glutamates, a lysine, and a cysteine. All postulated mechanisms involve covalent modification of the cysteine. Such covalently modified amino acids cannot be modelled by the best available modelling tools used in the field. I have developed a procedure that enables optimization of these amino acids using the Interactive Structure Optimization by Local Direct Exploration (ISOLDE) package incorporated in UCSF ChimeraX. In addition to coordinates that conventional docking programs rely on, ISOLDE employs electron density to minimize protein structures. Application of my protocols to the nitrilases has afforded substantial insight that potentially eliminates some mechanistic proposals.https://cassyni-user-files-prod.s3.amazonaws.com/2YFX3dJf7G2pK64DwGASRL https://cassyni.com/slides/outline/6kNsujxuaBK6Gv9CFLrXtZ https://cassyni.com/events/6kNsujxuaBK6Gv9CFLrXtZ/abstract https://cassyni-user-files-prod.s3.amazonaws.com/8NVMFPub4MrDiT8ueaVSTg https://cassyni.com/events/6kNsujxuaBK6Gv9CFLrXtZ?videoPreview=1 Bilingualism, the Brain and Societynohttps://cassyni.com/events/6kNsujxuaBK6Gv9CFLrXtZ?videoPreview=12021-09-15T06:00:00+00:003780.24Part of the nonprofit Annual Reviews organizationFor many stuck in Covid lockdowns, learning a new language offered respite — and possibly gave their brains a boost. Studies find that actively speaking two languages later in life may help to delay the cognitive decline associated with Alzheimer’s and other kinds of dementia. Research also suggests that children who grow up using two languages do better on standardized tests than their monolingual peers. But in many places bilingualism is not always valued. In the United States, for example, white, affluent English speakers are often encouraged to learn a second language, yet many people in poor, minority or indigenous communities are actively discouraged from speaking anything other than English. Join us for a discussion with two leading experts on bilingualism’s role in cognition and how speaking multiple languages may be lauded or frowned on depending on the societal context.https://cassyni-user-files-prod.s3.amazonaws.com/8NVMFPub4MrDiT8ueaVSTg https://cassyni.com/slides/outline/S1h4q2iG6PqjsCeKNKH1Vf https://cassyni.com/events/S1h4q2iG6PqjsCeKNKH1Vf/abstract https://cassyni-user-files-prod.s3.amazonaws.com/FUC14uCdcat6aSbdej8f2v https://cassyni.com/events/S1h4q2iG6PqjsCeKNKH1Vf?videoPreview=1 Changing Library Priorities in an AI Worldnohttps://cassyni.com/events/S1h4q2iG6PqjsCeKNKH1Vf?videoPreview=12026-01-13T13:00:00+00:003552.24Academic Publishing in EuropeHow are AI tools reshaping libraries’ strategies, services, and workflows—and what kinds of content, platforms, and tools are libraries now seeking from publishers?https://cassyni-user-files-prod.s3.amazonaws.com/FUC14uCdcat6aSbdej8f2v https://cassyni.com/events/7F2UxRcS1ds9Ggg5qn9L9s/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Bq8zz9ZxdnyowY4SF9ss8r https://cassyni.com/slides/outline/otqSuVfBbn4spRrEs9YAR https://cassyni.com/events/otqSuVfBbn4spRrEs9YAR/abstract https://cassyni-user-files-prod.s3.amazonaws.com/PbSWek9nZAZVzbWytKjPLi https://cassyni.com/events/otqSuVfBbn4spRrEs9YAR?videoPreview=1 Numerical modeling of solar inertial modesnohttps://cassyni.com/events/otqSuVfBbn4spRrEs9YAR?videoPreview=12023-03-16T06:00:00+00:002743.64Leeds Institute for Fluid DynamicsThis study addresses the characterization and modeling of solar inertial modes—global oscillations in the Sun’s convection zone whose restoring force is the Coriolis force—offering a complementary helioseismic tool distinct from conventional high-frequency p and g modes. Three main classes of Rossby (inertial) modes are examined: classical (retrograde-propagating, toroidal, non-convective), thermal (prograde-propagating, convectively driven, density-stratification dependent), and topographic (retrograde-propagating, confined near the poles, linked to spherical shell curvature). Numerical approaches include linear eigenvalue analyses incorporating realistic solar stratification, differential rotation, and turbulent diffusion; fully nonlinear rotating convection simulations; and mean-field modeling with parameterized turbulent transport. Key findings reveal that classical Rossby modes are clearly observed and well reproduced by linear theory, including the influence of turbulent viscosity and solar differential rotation, which modifies mode structure and explains observed latitudinal eigenfunction sign changes. Thermal Rossby modes dominate nonlinear simulations, transporting substantial enthalpy and angular momentum, though they remain undetected observationally, highlighting the convective conundrum. Topographic Rossby modes, previously overlooked, are shown to be baroclinically unstable when latitudinal entropy gradients are included, producing spiraling polar flow patterns consistent with solar observations and transporting heat pole-to-equator. Mean-field models demonstrate that these baroclinic modes modulate solar differential rotation by relaxing latitudinal entropy variations, implying that neglecting nonaxisymmetric inertial modes in 2D models may overestimate differential rotation amplitudes. The detection of baroclinic topographic modes provides indirect evidence for subtle (~7 K) latitudinal temperature variations in the solar convection zone, inaccessible by direct measurement but inferable through inertial mode analysis. This integrated modeling framework advances understanding of solar interior dynamics and offers new diagnostics for helioseismology.https://cassyni-user-files-prod.s3.amazonaws.com/PbSWek9nZAZVzbWytKjPLi https://cassyni.com/slides/outline/GdLxqQuQMLPR8S9Dkucu2V https://cassyni.com/events/GdLxqQuQMLPR8S9Dkucu2V/abstract https://cassyni-user-files-prod.s3.amazonaws.com/QuCwFs5jkeNgjsJGWPz8ge https://cassyni.com/events/GdLxqQuQMLPR8S9Dkucu2V?videoPreview=1 Managing AI Risks: from Governance to Insurancenohttps://cassyni.com/events/GdLxqQuQMLPR8S9Dkucu2V?videoPreview=12025-09-26T01:00:00+00:003703.4Risk Sciences[***Risk Sciences***](https://www.keaipublishing.com/en/journals/risk-sciences/) aims to foster diverse, multidisciplinary insights in risk sciences, bridging theory and practice through a series of academic activities. This speech record is an excerpt from Dr. von Gablenz and Dr. Li's keynote speech for the [Risk Sciences Colloquium – Artificial Intelligence and Risk Management](https://www.keaipublishing.com/en/journals/risk-sciences/event/risk-sciences-colloquium-artificial-intelligence-and-risk-management/) , which was held on September, 26, 2025, in Beijing, China.https://cassyni-user-files-prod.s3.amazonaws.com/QuCwFs5jkeNgjsJGWPz8ge https://cassyni.com/events/BgrvNaS9xkrPjLRskRuuJM/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Nq1eMnWxZ47jGoetbk56mc https://cassyni.com/slides/outline/Q36eeJ8ALZcymVN61MR557 https://cassyni.com/events/Q36eeJ8ALZcymVN61MR557/abstract https://cassyni-user-files-prod.s3.amazonaws.com/BY3pxMj3KjKMxC8BrEU6nJ https://cassyni.com/events/Q36eeJ8ALZcymVN61MR557?videoPreview=1 Seed dispersers help plants keep up with climate change on mountainsnohttps://cassyni.com/events/Q36eeJ8ALZcymVN61MR557?videoPreview=12025-08-04T14:00:00+00:002571.84NoneClimate change is forcing species to shift their distributions to track suitable climates. For sessile organisms such as plants, the dispersal of their seeds is crucial, as it is their only opportunity to move. Thus, on mountains, animal seed dispersers may be important in helping plants ascend to higher altitudes. However, the role of animal dispersers remains poorly understood due to a lack of empirical datasets spanning multiple disperser guilds along elevational gradients. To address this gap, I built seed dispersal networks for the five altitudinal vegetation belts of Tenerife Island (0-3,718 m a.s.l.) to evaluate whether animal dispersers enable plants to colonise higher elevations under climate change. The overall network comprised 283 unique interactions among 73 plant and 27 animal species. Seed dispersers functionally connect vegetation belts, offering viable pathways for plants to colonise upper areas. Furthermore, 11 plant species were dispersed to higher elevations beyond their current distribution range, achieving vertical distances exceeding those required to escape rising temperatures. Nonetheless, over half of the plants reaching higher elevations were exotic. This work suggests that diverse disperser communities are key for helping plants track climate change on mountainous, yet exotic plants may also benefit from this upward lift.https://cassyni-user-files-prod.s3.amazonaws.com/BY3pxMj3KjKMxC8BrEU6nJ https://cassyni.com/slides/outline/K6ccBTeuwz5xNPejzsi5Ly https://cassyni.com/events/K6ccBTeuwz5xNPejzsi5Ly/abstract https://cassyni-user-files-prod.s3.amazonaws.com/8ovYBMvKZYkTLCUyPHcvii https://cassyni.com/events/K6ccBTeuwz5xNPejzsi5Ly?videoPreview=1 Differentiable flow solvers and online learning for the dynamical systems view of turbulence nohttps://cassyni.com/events/K6ccBTeuwz5xNPejzsi5Ly?videoPreview=12026-01-28T14:00:00+00:003426.04Department of AeronauticsOnline learning is a technique in which a differentiable flow solver is included inside the training loop for a neural network. One common use case in fluid mechanics is subgrid scale parameterizations in turbulence. In that problem, online learning produces schemes that are more stable than their “offline” counterparts, but the approach can also be used in a variety of other problems, including solution discovery and state estimation. In this talk I will describe three problems rooted in a “dynamical systems” view of fluid motion in which differentiable solvers play a critical role. First, I will show how the search for unstable periodic orbits – exact solutions of the Navier-Stokes equations which contain a particular recurrent process relevant to the chaotic flow – can be framed as an optimization problem. A scalar loss function which measures the distance between the state and its location a time $T$ later is minimized using a combination of automatic differentiation through the solver in combination with a high-dimensional optimizer. The approach converges an order of magnitude more solutions in a two-dimensional Kolmogorov flow than have been computed by earlier methods. In the second problem, I will present an online-learning algorithm for super resolution. Super resolution refers to the prediction of a high-resolution flow snapshot (usually with a neural network) given coarse-grained observations. In contrast to the usual approach, our method does not require a library of high resolution snapshots: the loss function is a modification of the variational 4DVar algorithm for state estimation and seeks to match the coarse-grained evolution of the predicted state to measurements. I will compare the performance to classical 4DVar and assess the impact of known limiting lengthscales for assimilation. I will also show how these ideas can be applied in non-Newtonian fluids where key dynamical variables cannot be measured expreimentally. Finally, I will describe a method to learn mappings between a family of dynamical systems, with a training algorithm motivated by the definition of topological equivalence. The resulting neural networks allow for continuation of arbitrary solutions of the governing equations and extend the standard dynamical systems toolbox which can follow statistically-steady states only. https://cassyni-user-files-prod.s3.amazonaws.com/8ovYBMvKZYkTLCUyPHcvii https://cassyni.com/slides/outline/VUEJ9pEwAbiNttwt1yey2V https://cassyni.com/events/VUEJ9pEwAbiNttwt1yey2V/abstract https://cassyni-user-files-prod.s3.amazonaws.com/N92nyaFetFx4HsB2LkEHxJ https://cassyni.com/events/VUEJ9pEwAbiNttwt1yey2V?videoPreview=1 Machine Learning for Space Weather and the challenge of rare and extreme eventsnohttps://cassyni.com/events/VUEJ9pEwAbiNttwt1yey2V?videoPreview=12025-12-11T20:00:00+00:003966.0AI Institute in Dynamic SystemsSpace weather refers to the conditions in near-Earth space driven by solar activity—solar flares, coronal mass ejections, and geomagnetic storms—that can disrupt satellites, radio communication, navigation systems, and power grids. In recent years, the field has been revolutionized by the rapid improvement in data-driven and machine learning based forecasting. Yet the events that matter most for operational decision-making are precisely those that occur least often. This creates a core scientific challenge: our models must anticipate the rare and the extreme, even though the historical record is dominated by quiet days. Classical machine learning methods struggle in this setting. In regression tasks with strongly imbalanced target distributions, “more data” often means “more of the same,” offering limited benefit. The data that capture extremes are far more informative than abundant but redundant samples. In this talk, I will give an overview on recent advances of machine learning in the broad field of space weather and space physics. Emphasis will be given on three complementary methods that address the imbalanced regression challenge. ACCRUE (Accurate and Reliable Uncertainty Estimate) is a model-agnostic post-hoc technique that converts deterministic models into probabilistic ones with calibrated and trustworthy uncertainties. PARIS (Pruning Algorithm via the Representer theorem for Imbalanced Scenarios) applies influence-aware sample attribution to identify and remove redundant or counterproductive data, improving performance specifically on rare events. ProBoost (Probabilistic Boosting) integrates the two ideas, forming an uncertainty-weighted ensemble in which each model contributes proportionally to its calibrated confidence. Although motivated by space weather prediction, these approaches are broadly applicable to any domain where rare or extreme events—not the majority of the data—drive the real-world risk.https://cassyni-user-files-prod.s3.amazonaws.com/N92nyaFetFx4HsB2LkEHxJ https://cassyni.com/slides/outline/UUw64SwtHgcEE97sv1BeDb https://cassyni.com/events/UUw64SwtHgcEE97sv1BeDb/abstract https://cassyni-user-files-prod.s3.amazonaws.com/JBZfnaiYtFJSXXkKjipozN https://cassyni.com/events/UUw64SwtHgcEE97sv1BeDb?videoPreview=1 Resolved: AI Tools Will Provide a Net Benefit to Scholarly Communicationnohttps://cassyni.com/events/UUw64SwtHgcEE97sv1BeDb?videoPreview=12026-02-24T16:15:00+00:003591.0Researcher to ReaderTwo debaters argue for and against the proposition. This will be a formal debate, with the result decided by the impact of the arguments on all the Conference participants. An initial ‘baseline’ vote is taken at the start of the debate, and another vote is taken at the end. The winner is the side that has swayed opinion in their favour.https://cassyni-user-files-prod.s3.amazonaws.com/JBZfnaiYtFJSXXkKjipozN https://cassyni.com/events/7jhi7jmqrTLy69fbdtGJL5/abstract https://cassyni-user-files-prod.s3.amazonaws.com/HnMMbDFgym8J3vp9yDxj9G https://cassyni.com/slides/outline/EenAmJqBzs6kaxfB1KqEUm https://cassyni.com/events/EenAmJqBzs6kaxfB1KqEUm/abstract https://cassyni-user-files-prod.s3.amazonaws.com/5vN8Lg2jzShtPFqmiML8pe https://cassyni.com/events/EenAmJqBzs6kaxfB1KqEUm?videoPreview=1 Academic Data Hubs in the Era of Cloud and AInohttps://cassyni.com/events/EenAmJqBzs6kaxfB1KqEUm?videoPreview=12025-08-01T06:00:00+00:003643.6AAMCThis webinar showcases NYU Grossman School of Medicine’s Academic Data Hubs initiative. By leveraging cloud technologies, AI, and large language models, these hubs centralize data, strengthen governance, and enhance analytics for education, faculty, and research administration. The speaker highlights the strategy, design, and real-world use cases demonstrating how curated data hubs enable precision medical education and workflow optimization. This webinar is part of the Artificial Intelligence in Academic Medicine Webinar Series, hosted by the AAMC. It explores critical concepts, the current landscape, and practical strategies drawn from various perspectives and institutions to support you in navigating the evolving world of AI in academic medicine. For more information, see [the complete series webpage](https://www.aamc.org/about-us/mission-areas/medical-education/artificial-intelligence-ai-academic-medicine-webinar-series). https://cassyni-user-files-prod.s3.amazonaws.com/5vN8Lg2jzShtPFqmiML8pe https://cassyni.com/events/F9RmozUiSKeoajC4bm82k5/seminar/qa https://cassyni.com/slides/outline/F9RmozUiSKeoajC4bm82k5 https://cassyni.com/events/F9RmozUiSKeoajC4bm82k5/abstract https://cassyni-user-files-prod.s3.amazonaws.com/5GnbvJrWM5rB6HvY7JXgFx https://cassyni.com/events/F9RmozUiSKeoajC4bm82k5?videoPreview=1 JWPE 3-min Pitch 2025: "My Life in Water" - Part 1 nohttps://cassyni.com/events/F9RmozUiSKeoajC4bm82k5?videoPreview=12025-12-02T10:00:00+00:001984.88ElsevierThe JWPE 3-Minute Pitch - 'My Life in Water' is a global initiative that celebrates the outstanding research conducted by PhD students from any country working in the area of water processing and engineering. It aims at supporting dissemination and outreach training to develop capacity building for JWPE’s outcoming and emerging researchers. The challenge is for PhD students to encapsulate their research in a three-minute presentation, using language understandable to a non-specialist audience.https://cassyni-user-files-prod.s3.amazonaws.com/5GnbvJrWM5rB6HvY7JXgFx https://cassyni.com/events/QXmsocHaBP6oaxMboTY3FK/abstract https://cassyni-user-files-prod.s3.amazonaws.com/D6Mh9RgR5E3BBPJz83oRu8 https://cassyni.com/slides/outline/KbHqLmpKnoZnBreFnyq3XB https://cassyni.com/events/KbHqLmpKnoZnBreFnyq3XB/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Ux7htFAYUBAgHPTsm4RKAW https://cassyni.com/events/KbHqLmpKnoZnBreFnyq3XB?videoPreview=1 From Submission to Acceptance: Writing Strong Manuscripts and Decoding Peer Reviewnohttps://cassyni.com/events/KbHqLmpKnoZnBreFnyq3XB?videoPreview=12025-09-30T08:00:00+00:002896.76Thieme India ChemTalksAcademic manuscript submission often encounters high rejection rates, frequently exceeding 60% in leading journals, with decisions based not only on research quality but also on journal fit, presentation, and clarity. This analysis provides strategies for developing strong manuscripts and effectively navigating the peer review process. Common reasons for rejection include poor presentation, mismatched journal scope, or a lack of significant novel insights. Editors prioritize a clear alignment with journal scope, demonstrated novelty, and data integrity. Authors are advised to carefully select journals whose focus, such as synthetic methodologies, catalysis, or natural product synthesis, matches their work. Manuscript preparation should feature a concise, informative title and an abstract that summarizes the problem, methodology, key results, and conclusion. The introduction should employ a funnel model, outlining the scientific problem, reviewing existing literature, and clearly articulating how the current work addresses identified gaps. The results and discussion sections require a logical narrative and transparent data presentation to ensure conclusions are well-supported. Comprehensive and well-organized supporting information is crucial for establishing trust and validating findings. Ethical compliance is paramount, strictly prohibiting plagiarism, data fabrication, and duplicate publication, including salami-slicing, as these are grounds for immediate rejection. When responding to reviewer feedback, authors should address each comment point-by-point, providing logical justifications for any disagreements. Ultimately, clear writing, compelling novelty, and scientific significance are vital for increasing manuscript acceptance rates and enhancing scholarly communication.https://cassyni-user-files-prod.s3.amazonaws.com/Ux7htFAYUBAgHPTsm4RKAW https://cassyni.com/slides/outline/XwVwVrzSmFQe5Xt4mLPmfK https://cassyni.com/events/XwVwVrzSmFQe5Xt4mLPmfK/abstract https://cassyni-user-files-prod.s3.amazonaws.com/CaQubM4mBsjNjNWTaKK1gz https://cassyni.com/events/XwVwVrzSmFQe5Xt4mLPmfK?videoPreview=1 Neuromorphic Opto-Electronics for Next-Generation Compute: Opportunities & Challengesnohttps://cassyni.com/events/XwVwVrzSmFQe5Xt4mLPmfK?videoPreview=12026-02-18T13:30:00+00:002376.44UK Metamaterials NetworkEvery computational task, from basic arithmetic to the training of sophisticated language models, relies on translating high-level software instructions into sequences of charge manipulations in silicon. This translation becomes increasingly inefficient when applied to modern AI workloads, where the mapping of each neuron, connection, and synapse into transistor operations is fundamentally bottlenecked. In this talk, I will cover recent demonstrations of active and brain-inspired opto-electronic devices which leverage the bandwidth and speed of photonics for parallel information processing and storage. I will focus on device-level implementations and extend the discussion to larger architectures and small-scale accelerators. https://cassyni-user-files-prod.s3.amazonaws.com/CaQubM4mBsjNjNWTaKK1gz https://cassyni.com/events/MZXA3KhuJwjiyJBe9uk5GH/abstract https://cassyni-user-files-prod.s3.amazonaws.com/DgQFPKYqdj22sT7874445c https://cassyni.com/events/UyFDjaQmtp3ZTsi77nbogH/seminar/qa https://cassyni.com/slides/outline/UyFDjaQmtp3ZTsi77nbogH https://cassyni.com/events/UyFDjaQmtp3ZTsi77nbogH/abstract https://cassyni-user-files-prod.s3.amazonaws.com/LKkYvmnxompDEHyDu9JL2J https://cassyni.com/events/UyFDjaQmtp3ZTsi77nbogH?videoPreview=1 From Bench to Bedside: The Mission of Therapeutics Nownohttps://cassyni.com/events/UyFDjaQmtp3ZTsi77nbogH?videoPreview=12026-03-16T14:30:00+00:005695.84Thieme BioSciencesThis inaugural webinar introduces *Therapeutics Now*, a new journal dedicated to publishing high-quality research across the entire therapeutics pipeline, from molecular discovery and preclinical validation to clinical development and regulatory science. The session will outline the journal’s vision, editorial scope, article types, and its mission to accelerate translational impact. Attendees will also meet members of the Editorial Board and learn how they can contribute to and engage with the journal.https://cassyni-user-files-prod.s3.amazonaws.com/LKkYvmnxompDEHyDu9JL2J https://cassyni.com/events/Gd37aVEevNCRWstxepghrV/seminar/qa https://cassyni.com/slides/outline/Gd37aVEevNCRWstxepghrV https://cassyni.com/events/Gd37aVEevNCRWstxepghrV/abstract https://cassyni-user-files-prod.s3.amazonaws.com/VEB7VcwFfGsnBLWQF7uJyC https://cassyni.com/events/Gd37aVEevNCRWstxepghrV?videoPreview=1 Particle Size Distributions: Effects on the mechanics of granular materials and the need for community-driven approachesnohttps://cassyni.com/events/Gd37aVEevNCRWstxepghrV?videoPreview=12026-04-22T12:00:00+00:003851.24Granular MatterGranular materials behave in complex ways, driven by particle characteristics such as size, shape, mineralogy, and surface roughness. Despite major advances from experiments and numerical modelling, linking particle-scale features to bulk mechanical response remains a fundamental challenge. Particle size distributions (PSDs) sit at the heart of this problem. In discrete element method (DEM) simulations, however, their representation is often simplified due to computational cost—raising important questions about accuracy, efficiency, and the reliability of predictions. In this webinar, experimental and numerical examples highlight some challenges in modelling PSD effects, and their impact on the observed DEM results. It will be argued that tackling these challenges requires a shift towards community-driven research and the wider adoption of open-source DEM tools—enabling more transparent, reproducible, and collaborative progress across the field. https://cassyni-user-files-prod.s3.amazonaws.com/VEB7VcwFfGsnBLWQF7uJyC https://cassyni.com/events/BgZ57emQXnfQ7nBceLyi8M/seminar/qa https://cassyni.com/slides/outline/BgZ57emQXnfQ7nBceLyi8M https://cassyni.com/events/BgZ57emQXnfQ7nBceLyi8M/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Luf51Pjc7A7UCfzEeCgTrv https://cassyni.com/events/BgZ57emQXnfQ7nBceLyi8M?videoPreview=1 GenAI models for urban water systems: Opportunities, challenges and future directionsnohttps://cassyni.com/events/BgZ57emQXnfQ7nBceLyi8M?videoPreview=12026-06-11T14:00:00+00:001902.48Cambridge PrismsGenerative artificial intelligence (AI), particularly large language models, offers transformative potential for the management and operation of urban water systems. As water utilities face increasing pressures from climate change, ageing infrastructure and population growth, AI-driven tools provide new opportunities for real-time monitoring, predictive maintenance and enhanced decision support. This article explores how generative AI can revolutionise the water industry by enabling more efficient operations, improved customer engagement and advanced training mechanisms. It examines current applications, such as AI-integrated supervisory control and data acquisition systems and conversational interfaces, and evaluates their performance through emerging case studies. While highlighting the benefits, the article also addresses key challenges, including data privacy, model reliability, ethical considerations and regulatory uncertainty. Through a balanced analysis of opportunities and risks, this study outlines future directions for research and policy, offering practical recommendations for the responsible adoption of generative AI in urban water management to improve resilience, efficiency and sustainability across the sector.https://cassyni-user-files-prod.s3.amazonaws.com/Luf51Pjc7A7UCfzEeCgTrv https://cassyni.com/slides/outline/BBsqxLbzgyBaJKC6rErjx9 https://cassyni.com/events/BBsqxLbzgyBaJKC6rErjx9/abstract https://cassyni-user-files-prod.s3.amazonaws.com/AneQhg8D8t39SWZK1AXKne https://cassyni.com/events/BBsqxLbzgyBaJKC6rErjx9?videoPreview=1 Session 5A: Photo-electrochemical (PEC) and Photocatalysis (PC)nohttps://cassyni.com/events/BBsqxLbzgyBaJKC6rErjx9?videoPreview=12025-10-22T22:00:00+00:006377.0Centre for Energy TechnologyThis seminar session critically examines advances and challenges in photoelectrochemical (PEC) and photocatalytic (PC) water splitting for green hydrogen production, emphasizing material development, system design, and techno-economic considerations. The discussion highlights the fundamental trade-offs in photocatalyst design, particularly balancing band gap width for visible-light absorption with sufficient driving force for water redox reactions. Innovative approaches include the development of narrow band gap oxysulfide and oxynitride photocatalysts, selective dual co-catalyst deposition to enhance charge separation, and the fabrication of scalable photocatalyst sheets integrating solid mediators to improve electron transfer and stability. Z-scheme systems, both in suspension and with spatially separated reaction chambers, demonstrate improved solar-to-hydrogen (STH) efficiencies up to 2.5%, with outdoor panel reactors achieving around 1.2% STH. Techno-economic analyses underscore the necessity of increasing efficiency and reducing system costs to approach the target hydrogen production cost of approximately $1–3.5 per kilogram, with system designs evolving toward simplified, scalable reactors minimizing ancillary costs. The session also addresses the critical need for standardized testing protocols and international collaboration to ensure reproducibility and accelerate industrial adoption. While current efficiencies remain below the ideal 20–30% STH, incremental improvements in material quality, charge separation, and device engineering are projected to enable practical applications, particularly for niche uses where hydrogen storage and intermittent production are acceptable. The integration of advanced characterization techniques and interdisciplinary efforts is emphasized as essential for overcoming existing “valleys of death” in scaling solar-driven hydrogen technologies.https://cassyni-user-files-prod.s3.amazonaws.com/AneQhg8D8t39SWZK1AXKne https://cassyni.com/slides/outline/J6yviYBEEjs5wbt5WFN7jT https://cassyni.com/events/J6yviYBEEjs5wbt5WFN7jT/abstract https://cassyni-user-files-prod.s3.amazonaws.com/NdgQ2FuBKiW9xrU8rHQpVt https://cassyni.com/events/J6yviYBEEjs5wbt5WFN7jT?videoPreview=1 Momentum-Conserving Physics-Informed Graph Neural Networks for Dynamical Systemsnohttps://cassyni.com/events/J6yviYBEEjs5wbt5WFN7jT?videoPreview=12026-02-19T17:00:00+00:003977.8AI Institute in Dynamic SystemsAccurate and interpretable modeling of multi-body dynamical systems is a fundamental challenge in domains ranging from robotics and aerospace to biophysics and materials science. Traditional physics-based approaches are often computationally expensive and difficult to scale, while purely data-driven methods like graph neural networks (GNNs) may lack physical consistency and generalization. This talk presents Dynami-CAL GraphNet, a new physics-informed GNN framework that explicitly integrates conservation laws, specifically, the pairwise conservation of linear and angular momentum, into its architecture. By leveraging edge-local reference frames that are equivariant to rotations and translations, our model produces physically consistent predictions and offers interpretable insights into the forces and moments governing each interaction. We demonstrate the effectiveness of Dynami-CAL GraphNet across a wide spectrum of tasks. Beyond standard 3D granular systems with inelastic collisions, we systematically evaluated the model on complex, real-world datasets, including human body motion prediction and protein molecular dynamics simulations. In all cases, Dynami-CAL GraphNet was benchmarked against several established baseline methods. Our results show not only stable error accumulation over extended prediction horizons and superior maintenance of physical constraints, but also a strong ability to extrapolate to previously unseen system configurations and interaction regimes, a key capability for robust deployment in real-world scenarios. This talk will highlight how embedding physical principles within machine learning architectures enables not only accuracy and interpretability, but also robust extrapolation to previously unseen scenarios, opening new avenues for real-time, scalable, and generalizable modeling of complex systems in science and engineering. https://cassyni-user-files-prod.s3.amazonaws.com/NdgQ2FuBKiW9xrU8rHQpVt https://cassyni.com/slides/outline/Tyx1eD7j1twQo7t71p8UsP https://cassyni.com/events/Tyx1eD7j1twQo7t71p8UsP/abstract https://cassyni-user-files-prod.s3.amazonaws.com/J5mruTRYuizrswNopHS4JJ https://cassyni.com/events/Tyx1eD7j1twQo7t71p8UsP?videoPreview=1 Is energy efficiency a worthwhile investment?nohttps://cassyni.com/events/Tyx1eD7j1twQo7t71p8UsP?videoPreview=12016-11-03T06:00:00+00:00338.96 School of Public PolicyAn interview with Dr. Marilyn A. Brown from the School of Public Policy, Georgia Institute of Technology, co-author of Fact and Fiction in Global Energy Policy, and co-recipient of the 2007 Nobel Peace Prize for her research on mitigating climate change.https://cassyni-user-files-prod.s3.amazonaws.com/J5mruTRYuizrswNopHS4JJ https://cassyni.com/events/6k52epJA9D86fMtw9FvLiZ/seminar/qa https://cassyni.com/slides/outline/6k52epJA9D86fMtw9FvLiZ https://cassyni.com/events/6k52epJA9D86fMtw9FvLiZ/abstract https://cassyni-user-files-prod.s3.amazonaws.com/3kkciq6DSzsC4wZ12BqyP4 https://cassyni.com/events/6k52epJA9D86fMtw9FvLiZ?videoPreview=1 Multi-scale Network Neurosciencenohttps://cassyni.com/events/6k52epJA9D86fMtw9FvLiZ?videoPreview=12026-02-20T18:00:00+00:003453.76School of Data ScienceConnectomes are comprehensive maps of the wiring within nervous systems, representing connections from the cellular and synaptic level (on the nanometer scale) to large-scale brain areas (on the centimeter scale). Network neuroscience focuses on modeling and analyzing these connectomes. While the primary goal of network neuroscience—understanding the principles of connectome organization and its impact on brain function—remains consistent across different scales, specific scientific questions often require examining particular spatial levels. For instance, exploring the relationship between clinical outcomes and connectome organization in humans currently requires analysis at the areal level. In my talk, I will present several ongoing research projects from my lab that span multiple scales of network neuroscience. These include nanoscale connectome analyses from model organisms such as C. elegans, Drosophila, and zebrafish, as well as large-scale functional MRI studies. I will conclude with a discussion of key open questions and challenges in the field, along with potential directions for advancing the discipline.https://cassyni-user-files-prod.s3.amazonaws.com/3kkciq6DSzsC4wZ12BqyP4 https://cassyni.com/slides/outline/Jbf9srLe5ZLum4sbJMV5uf https://cassyni.com/events/Jbf9srLe5ZLum4sbJMV5uf/abstract https://cassyni-user-files-prod.s3.amazonaws.com/QFCe87AX8duHwa4f8fL3ae https://cassyni.com/events/Jbf9srLe5ZLum4sbJMV5uf?videoPreview=1 D4 – One Dataset, Many Audiences: Designing Research Reporting That Actually Gets Usednohttps://cassyni.com/events/Jbf9srLe5ZLum4sbJMV5uf?videoPreview=12026-04-20T13:30:00+00:002841.52Research Analytics SummitHow do research institutions communicate the same data to audiences with very different needs, responsibilities, and levels of data fluency—without oversimplifying or overwhelming? This session presents practical approaches from the University of Arizona and Texas Tech University, where teams have developed flexible reporting frameworks that align metrics with leadership priorities, support users through training and consultation, and ensure secure, role-appropriate access to research data. Through brief case examples, presenters will illustrate how audience-specific reporting structures can improve stakeholder engagement and increase the use of data for decision-making. The session will then shift to a facilitated discussion in which participants can compare practices, surface common challenges, and exchange concrete ideas for improving data communication in their own organizations. Designed for beginner to intermediate audiences, this session offers actionable models and a collaborative space to explore what effective, audience-specific research reporting looks like in real institutional settings.https://cassyni-user-files-prod.s3.amazonaws.com/QFCe87AX8duHwa4f8fL3ae https://cassyni.com/events/K6JkvXzAX1txkqQUtnmtAy/abstract https://cassyni-user-files-prod.s3.amazonaws.com/3bgJEUYt9xctc92TfBo62a https://cassyni.com/slides/outline/VTvSttaBjdXPHLhcutimrV https://cassyni.com/events/VTvSttaBjdXPHLhcutimrV/abstract https://cassyni-user-files-prod.s3.amazonaws.com/6Adfu7P87W91pV4nQEUFLr https://cassyni.com/events/VTvSttaBjdXPHLhcutimrV?videoPreview=1 I1 – Implementing and Leveraging RIM Systems for Research Analytics: Partnerships and Institutional Use Casesnohttps://cassyni.com/events/VTvSttaBjdXPHLhcutimrV?videoPreview=12026-04-21T13:30:00+00:002722.52Research Analytics SummitAs the research enterprise becomes increasingly data – driven, higher education institutions rely on interconnected practices to understand and advance their research mission, including research information management (RIM), research analytics, persistent identifiers, and impact assessment. Library professionals play a pivotal role by contributing expertise in RIM systems administration; building interconnected institutional data ecosystems; and overseeing the technical infrastructure that supports annual review processes. This panel brings together four library professionals whose work intersects directly with institutional strategy through collaboration with faculty, research offices, sponsored programs, and academic leadership to generate insights, strengthen research visibility, and promote responsible evaluation practices. The panelists offer a multi – institutional view of how research analytics, persistent identifiers, open scholarship, and metadata stewardship intersect in practice. They will discuss the operational realities of RIM System administration and how library professionals bridge faculty needs and leadership priorities, including close collaboration with campus partners to manage Faculty Activity Reports and ensure their seamless integration with RIM systems. Through discussion of implementation challenges, cross – campus collaboration, and patterns of adoption and resistance, the panel will highlight a variety of institutional priorities and practices.https://cassyni-user-files-prod.s3.amazonaws.com/6Adfu7P87W91pV4nQEUFLr https://cassyni.com/events/EeUKWPASZtukyQQuuEu3Jm/seminar/qa https://cassyni.com/slides/outline/EeUKWPASZtukyQQuuEu3Jm https://cassyni.com/events/EeUKWPASZtukyQQuuEu3Jm/abstract https://cassyni-user-files-prod.s3.amazonaws.com/QC4DoeNLPizkdEvmTQNn2 https://cassyni.com/events/EeUKWPASZtukyQQuuEu3Jm?videoPreview=1 Image generation with end-to-end training and benefits of a good VAEnohttps://cassyni.com/events/EeUKWPASZtukyQQuuEu3Jm?videoPreview=12026-04-09T11:00:00+00:003568.04Journal on Image and Video ProcessingLatent diffusion models underly modern image generation, which requires a variational auto-encoder (VAE) for image encoding and decoding, and a diffusion transformer for generation. While end-to-end training has been the spirit of deep learning, it is surprising that latent diffusion models are not trained end-to-end, causing representation bottlenecks. In this talk, I will introduce our work that jointly trains the VAE and diffusion transformer and show how it accelerates training and yields high quality images. Further, I will discuss use cases where the resulting end-to-end trained VAEs bring significant benefits. This includes higher-quality text-to-image generation and automatic agentic search of diffusion transformer architectures. I will conclude with new perspectives. https://cassyni-user-files-prod.s3.amazonaws.com/QC4DoeNLPizkdEvmTQNn2 https://cassyni.com/events/F97vZ4oy1MToyAwoVgBqa5/seminar/qa https://cassyni.com/slides/outline/F97vZ4oy1MToyAwoVgBqa5 https://cassyni.com/events/F97vZ4oy1MToyAwoVgBqa5/abstract https://cassyni-user-files-prod.s3.amazonaws.com/J6myjx6f3S3TG218CGu43G https://cassyni.com/events/F97vZ4oy1MToyAwoVgBqa5?videoPreview=1 A variational approach to higher-order homogenizationnohttps://cassyni.com/events/F97vZ4oy1MToyAwoVgBqa5?videoPreview=12026-04-28T13:00:00+00:003278.96MetaMATIt is convenient to describe materials possessing a microstructure using homogeneous effective properties. When the ratio $\eta$ between the size of the microstructure and the size of the overall structure is very small, effective models can be obtained by applying a homogenization procedure. Asymptotic homogenization is particularly well-suited to treat periodic microstructures. This approach relies on an expansion of the mechanical fields in powers of the scale ratio $\eta$. At leading order, classical homogenization is recovered and a standard Cauchy medium is obtained. Next orders yield additional corrections, that depend on the successive strain gradients. By contrast with phenomenological approaches, asymptotic homogenization allows to rigorously identify the microscopic solution accounting for the effective behavior. Besides, the higher-order corrections permit to improve the accuracy of the model by capturing size-effects. These effects typically occur when the scale ratio $\eta$ is not sufficiently small or when the microscopic constituents have contrasted stiffness properties. Although accurate in the bulk region, the higher-order corrections produced by homogenization still miss significant boundary effects, which can strongly degrade the quality of the predictions. Besides, in these higher-order models, the order of the equilibrium equation is increased and new boundary conditions are required. In continuum mechanics, boundary conditions are usually derived by minimizing the energy of the system. For higher-order models such an energy is missing, which makes the identification of appropriate boundary conditions particularly difficult. Deriving such an energy present several challenges. First, the strain-gradient stiffness appearing in these models can be non-positive. A raw truncation of the bulk energy therefore yields a non-positive strain energy density. This property is highly undesirable as it leads to ill-posed boundary-value problems. Secondly, in order to guarantee the accuracy of the model, one must account for the energy generated by the boundary layers. This produces boundary contributions to the energy, that can be non-positive as well. In this work, we tackle the limitations mentioned above and uncover such an energy in 1D. We proceed in two steps. First, we combine asymptotic homogenization in the bulk and a rigorous boundary layer analysis in order to derive a formal approximation of the microscopic energy, that we call a pseudo-energy. This pseudo-energy contains a bulk term and a boundary term that are accurate up to order $\eta^2$ included. Besides, we show that the higher-order forces entering the boundary term satisfy some compatibility conditions which guarantee that the pseudo-energy can be made stationary order by order (perturbatively). As an example, we treat a 1D spring network with next-nearest neighbor interaction. We demonstrate that the predictions of this perturbative model are asymptotically exact at order $\eta^2$. Next, we propose a new procedure that transforms such a pseudo-energy into a truncated energy, restoring positivity. Two key ingredients are involved in this procedure. First, we restore positivity on the boundaries by transferring the boundary elasticity into a ghost term which, by construction, can be ignored. Next, we restore positivity in the bulk by applying a truncation method inspired from Cholesky decomposition. As a result, the obtained effective energy is positive and produces a well-posed boundary-value problem variationally. The energy is of the strain-gradient type, and is formulated in terms of a generalized strain. We further show on the example of the spring network, that the predictions of the model coincide with that of the perturbative approach. Finally, as an extension, we derive the pseudo-energy of a continuous laminate. In that case, the effective stiffnesses on boundary need to be computed numerically. Keywords : linear elasticity, higher-order homogenization, variational approach, boundary effects, positive energy, asymptotic analysishttps://cassyni-user-files-prod.s3.amazonaws.com/J6myjx6f3S3TG218CGu43G https://cassyni.com/slides/outline/9hzH3YhCBKNjaJhZtmC3ad https://cassyni.com/events/9hzH3YhCBKNjaJhZtmC3ad/abstract https://cassyni-user-files-prod.s3.amazonaws.com/A3CfADHRBaJQLFf3bx1raJ https://cassyni.com/events/9hzH3YhCBKNjaJhZtmC3ad?videoPreview=1 An interview with Dr. Robert Califfnohttps://cassyni.com/events/9hzH3YhCBKNjaJhZtmC3ad?videoPreview=12026-04-20T19:00:00+00:002227.04npj Digital Medicine Hear about the future of digital health from former FDA Commissioner Robert Califf. https://cassyni-user-files-prod.s3.amazonaws.com/A3CfADHRBaJQLFf3bx1raJ https://cassyni.com/slides/outline/N4E1KGPCZ89KcTdn9ghDMP https://cassyni.com/events/N4E1KGPCZ89KcTdn9ghDMP/abstract https://cassyni-user-files-prod.s3.amazonaws.com/M19EaqBXUaUsQo54KKEut https://cassyni.com/events/N4E1KGPCZ89KcTdn9ghDMP?videoPreview=1 Episode 2: Conversation with Michelle Monjenohttps://cassyni.com/events/N4E1KGPCZ89KcTdn9ghDMP?videoPreview=12025-08-20T09:00:00+00:002285.68Advanced ScienceIn this podcast, Dr. Michelle Monje (Stanford University) joins me to discuss: • Neuron - glioma interactions • Cancer neuroscience as a new hallmark • Immunotherapy challenges https://cassyni-user-files-prod.s3.amazonaws.com/M19EaqBXUaUsQo54KKEut https://cassyni.com/events/Kayz5r9aMqNnaJPzgttrMB/seminar/qa https://cassyni.com/slides/outline/Kayz5r9aMqNnaJPzgttrMB https://cassyni.com/events/Kayz5r9aMqNnaJPzgttrMB/abstract https://cassyni-user-files-prod.s3.amazonaws.com/K8pTjvijEfm5uK3CVH7puC https://cassyni.com/events/Kayz5r9aMqNnaJPzgttrMB?videoPreview=1 Thieme Cheminar: Safe and Sustainable by Design (SSbD): Advancing Innovation in Chemicals and Materialsnohttps://cassyni.com/events/Kayz5r9aMqNnaJPzgttrMB?videoPreview=12026-05-06T12:00:00+00:008521.28Thieme GroupThis Cheminar brings together leading experts to discuss recent advances in Safe and Sustainable by Design (SSbD), highlighting frameworks and practical approaches to integrate safety, sustainability, and circularity into chemicals, materials, and product innovation. Topics include conceptual SSbD frameworks, Safe-Sustainable-and-Recyclable-by-Design strategies for polymers, system-level barriers in circular economy transitions, and approaches linking material functionality with safety. The session features four invited talks showcasing research published in SCNOW and related EU projects, offering insights into how SSbD principles are being applied to drive sustainable innovation in chemistry and materials science. Speakers: • Lya Soeteman-Hernández • Simon Clavaguera • Irantzu Garmendia Aguirre • Denise Flahertyhttps://cassyni-user-files-prod.s3.amazonaws.com/K8pTjvijEfm5uK3CVH7puC https://cassyni.com/slides/outline/XwC6EwKhLHDeTydofFTaVK https://cassyni.com/events/XwC6EwKhLHDeTydofFTaVK/abstract https://cassyni-user-files-prod.s3.amazonaws.com/QNEFZbFzBNhH5DriGUzoie https://cassyni.com/events/XwC6EwKhLHDeTydofFTaVK?videoPreview=1 Supporting new investigators with their quantitative projects: principles and examplesnohttps://cassyni.com/events/XwC6EwKhLHDeTydofFTaVK?videoPreview=12026-06-25T20:00:00+00:003506.76Family MedicineBy the end of this lecture, participants will be able to: 1. Understand how to effectively support residents and medical students in designing and implementing quantitative projects 2. Recognize essential principles and resources for teaching about and implementing quantitative projects, including related to idea generation, project design and planning, identifying entity levels and levels of measurement, and selecting and using various data analysis and communication of findings strategies 3. Describe avoidable pitfalls in quantitative research design, implementation and analysis.https://cassyni-user-files-prod.s3.amazonaws.com/QNEFZbFzBNhH5DriGUzoie https://cassyni.com/slides/outline/2JHqTvWCzozfuRdj8ZAV5X https://cassyni.com/events/2JHqTvWCzozfuRdj8ZAV5X/abstract https://cassyni-user-files-prod.s3.amazonaws.com/9pzxTRPrxg53kbwaGm39X4 https://cassyni.com/events/2JHqTvWCzozfuRdj8ZAV5X?videoPreview=1 Stereotype Threat, Code-Switching, and Authenticity of Entrepreneursnohttps://cassyni.com/events/2JHqTvWCzozfuRdj8ZAV5X?videoPreview=12025-11-19T19:30:00+00:00907.28Center for Black Entrepreneurship, Spelman CollegeBlack entrepreneurs frequently encounter stereotype threat and discrimination, often employing code-switching as a coping mechanism, which raises questions about its impact on their authenticity and overall well-being. This study investigated the relationships between stereotype threat, code-switching, authenticity, and well-being among Black entrepreneurs. A conceptual model was developed where stereotype threat acts as an independent variable and code-switching as a mediator, with racial ideology (assimilationist versus nationalist beliefs, drawn from the multidimensional model of racial identity) explored as a contextual influence. Data were collected via a two-part survey from approximately 70 Black entrepreneurs, primarily within the Baltimore, DC, and Virginia areas. Initial findings revealed a significant negative relationship between stereotype threat and well-being. With updated data incorporating additional participants, code-switching was found to mediate the relationship between racial ideology and authenticity. Specifically, a nationalist ideology was linked to reduced feelings of authenticity when code-switching, which in turn negatively impacted well-being, whereas an assimilationist ideology showed positive relationships with felt authenticity. The findings suggest that Entrepreneur Support Organizations could develop targeted training programs to mitigate the negative effects of code-switching on the well-being of minority entrepreneurs. Future work involves expanding data collection, increasing participant numbers for enhanced statistical power, and exploring other forms of code-switching, as well as examining potential differences across socioeconomic status and diaspora groups.https://cassyni-user-files-prod.s3.amazonaws.com/9pzxTRPrxg53kbwaGm39X4 https://cassyni.com/slides/outline/4mXrhLjqC6mAGN7HgF57oT https://cassyni.com/events/4mXrhLjqC6mAGN7HgF57oT/abstract https://cassyni-user-files-prod.s3.amazonaws.com/L3R1gwgTHBHCEA4NfraWfx https://cassyni.com/events/4mXrhLjqC6mAGN7HgF57oT?videoPreview=1 Being Human 2023 - The Future In and Of Humanities: Rhyme Meets Reason?nohttps://cassyni.com/events/4mXrhLjqC6mAGN7HgF57oT?videoPreview=12023-11-16T09:00:00+00:004423.2NoneHow are the Humanities important in the future, how can they contribute to the challenges the future will bring, and in what ways can we study the future itself via humanities subjects? This wide-ranging and thought-provoking session, which was part of the 2023 Being Human Festival, examines how rhyme and reason might meet as we navigate manifold future challenges. Our esteemed panelists address a range of subjects in response to this dichotomy, including digital storytelling and AI-proof narrative skill sets, nihilism and tech, the role that the humanities can play in addressing future global challenges, and how literary speculations about the future compare to other methodologies.https://cassyni-user-files-prod.s3.amazonaws.com/L3R1gwgTHBHCEA4NfraWfx https://cassyni.com/slides/outline/DAZ8UxjketB9RhTkk6QB2M https://cassyni.com/events/DAZ8UxjketB9RhTkk6QB2M/abstract https://cassyni-user-files-prod.s3.amazonaws.com/RTbHYjDMjn1fs79vcK2S46 https://cassyni.com/events/DAZ8UxjketB9RhTkk6QB2M?videoPreview=1 The HKBU-produced Database on Sun Yat-sen Parks in the Worldnohttps://cassyni.com/events/DAZ8UxjketB9RhTkk6QB2M?videoPreview=12018-10-25T06:00:00+00:00907.12Hong Kong Baptist UniversityThis study investigates the construction of Sun Yat-sen as a political icon through an examination of memorial parks established in his honour across major Chinese communities worldwide. Leveraging a collaborative approach between the History Department and the Digital and Multimedia Service section of the Library at Hong Kong Baptist University, an online database on worldwide Sun Yat-sen Parks was developed. The project, conducted from the 2014-2015 to 2017-2018 academic years, aimed to systematically document and present these significant cultural sites. The resulting database, launched in Chinese in 2016 and English in 2017, features geographical locations and detailed textual and visual information for 106 Sun Yat-sen Parks. These parks are distributed globally, including 78 in Mainland China, 18 in Taiwan, 2 in Hong Kong, 1 in Singapore, 3 in the United States, and 3 in Canada. The platform incorporates an interactive world map, park lists, images, and videos, alongside findings on historical parks, re-dedicated sites, and parks featuring statues. Utilising digital technologies to classify materials and share research, the database has attracted over 334,000 views and led to a scholarly publication. This initiative underscores the value of digital humanities in broadening research scope and impact, demonstrating the efficacy of interdisciplinary collaboration between scholars and librarians in promoting historical studies and enhancing institutional visibility.https://cassyni-user-files-prod.s3.amazonaws.com/RTbHYjDMjn1fs79vcK2S46 https://cassyni.com/events/Cfw9Yuc7cnYpaiD7Q4f9cq/seminar/qa https://cassyni.com/slides/outline/Cfw9Yuc7cnYpaiD7Q4f9cq https://cassyni.com/events/Cfw9Yuc7cnYpaiD7Q4f9cq/abstract https://cassyni-user-files-prod.s3.amazonaws.com/AAN4RPCJHwSRkVypjLJzDC https://cassyni.com/events/Cfw9Yuc7cnYpaiD7Q4f9cq?videoPreview=1 Clinician-AI collaboration: Recent study and future directionsnohttps://cassyni.com/events/Cfw9Yuc7cnYpaiD7Q4f9cq?videoPreview=12026-07-23T22:00:00+00:002885.04npj Digital Medicine We discuss opportunities to design AI systems that function as collaborating partners for physicians rather than as standalone tools. The conversation is framed by a study published in npj Digital Medicine showing how an AI system designed to support a collaborative clinician-AI workflow can improve physicians' diagnostic performance.https://cassyni-user-files-prod.s3.amazonaws.com/AAN4RPCJHwSRkVypjLJzDC https://cassyni.com/events/WTJXL9QtpdQokGj7fcQDLy/abstract https://cassyni-user-files-prod.s3.amazonaws.com/VjXH2ik8XH6LHGG1hpG52E https://cassyni.com/events/K3sbpEvvcjtBVFvjMPvCV/seminar/qa https://cassyni.com/slides/outline/K3sbpEvvcjtBVFvjMPvCV https://cassyni.com/events/K3sbpEvvcjtBVFvjMPvCV/abstract https://cassyni-user-files-prod.s3.amazonaws.com/58LqaNxF8yv29Mpokjc23G https://cassyni.com/events/K3sbpEvvcjtBVFvjMPvCV?videoPreview=1 RAMP 2026-27 Community Call #1nohttps://cassyni.com/events/K3sbpEvvcjtBVFvjMPvCV?videoPreview=12026-07-07T19:00:00+00:002627.24Research Evaluation and Analytics Capacity HubApplications for the Research Analytics Mentorship Program (RAMP) open on July 8th! We are looking for both mentors and mentees looking to join a community of research analytics professionals dedicated to learning, collaboration, and professional growth. RAMP brings together research analytics professionals from across the country and international locations to share knowledge, expand their networks, and learn from one another through mentorship and peer collaboration. Whether you're interested in growing your skills as a mentee or sharing your experience as a mentor, we invite you to join our next cohort. Join our community call to learn more about the program, ask questions, and help to prepare your application. Both community calls will cover the same content for those interested in the program. https://cassyni-user-files-prod.s3.amazonaws.com/58LqaNxF8yv29Mpokjc23G https://cassyni.com/slides/outline/Wwx8Nq4RG5xrk3G1G3h1cH https://cassyni.com/events/Wwx8Nq4RG5xrk3G1G3h1cH/abstract https://cassyni-user-files-prod.s3.amazonaws.com/3ysPzWeW9iyXXNMS2p35gS https://cassyni.com/events/Wwx8Nq4RG5xrk3G1G3h1cH?videoPreview=1 Soil microbial diversity decline amplifies heat stress impacts on plant metabolism and productivitynohttps://cassyni.com/events/Wwx8Nq4RG5xrk3G1G3h1cH?videoPreview=12026-06-04T07:30:00+00:00672.0Soil microbial biodiversity is crucial for ecosystem stability, functionality, and sustainable food production. However, the combined effects of heatwaves and microbial diversity loss on plant productivity remain poorly understood. Since plant seeds harbour distinct endophytes that contribute to plant development and stress tolerance, we hypothesized that declining soil microbial diversity would reduce plant productivity and intensify heat-stress responses, while the functional composition of seed endophytes would remain relatively stable. We established a soil microbial diversity gradient by mixing agricultural and gamma-irradiated soils, and grew Setaria viridis through a full life cycle. Plant physiological and stress-related traits, together with rhizosphere microbial community structure and functional responses, were assessed under combined microbial diversity loss and heatwave stresses. A decline in soil microbial diversity was associated with significant reductions in plant height, biomass, root growth, and yield. Physiological stress indicators, such as malondialdehyde, proline, and anthocyanins, increased markedly, indicating that reduced soil microbial diversity acts as an environmental stressor. Heatwave exposure further changed leaf metabolomic and proteomic composition, including a strong upregulation of small heat shock proteins. Despite these changes, functional composition of seed endophytes remained similar to parental seeds, suggesting an inherent buffering capacity that may support reproductive success under environmental perturbations.https://cassyni-user-files-prod.s3.amazonaws.com/3ysPzWeW9iyXXNMS2p35gS https://cassyni.com/slides/outline/6FXv4eiBKCGuaayGjq6uvd https://cassyni.com/events/6FXv4eiBKCGuaayGjq6uvd/abstract https://cassyni-user-files-prod.s3.amazonaws.com/4yAc5swZ2e5gC8BS8nWQVL https://cassyni.com/events/6FXv4eiBKCGuaayGjq6uvd?videoPreview=1 A parallel between linear Landau damping and a similar phenomenon for neutral particlesnohttps://cassyni.com/events/6FXv4eiBKCGuaayGjq6uvd?videoPreview=12026-07-09T15:00:00+00:002626.12Journal of Plasma PhysicsThe Euler-Vlasov equation for sprays couple the dynamics of neutral particles (grains of sand, dust, ...) with a gas or a compressible fluid. A question is to understand the dynamics of such systems which are very common in engineering (diesel engines, ...). I will show that it is possible to write a dispersion relation which describes the dynamics linearized around certain rest profiles. It appears that the dispersion is extremely close to the well known dispersion relation in plasma (the one that describes the poles corresponding to linear Landau damping). Even if the physics is very different, the math is very close with some respects. I will explain the construction of this new dispersion relation. Illustration with a variety of numerical simulations show that other phenomenon can be obtained as well, such as the two stream instability. This is based on the PhD thesis of Victor Fournet. https://cassyni-user-files-prod.s3.amazonaws.com/4yAc5swZ2e5gC8BS8nWQVL https://cassyni.com/events/BghBgoLqYbJ2rUFU32HFWd/seminar/qa https://cassyni.com/slides/outline/BghBgoLqYbJ2rUFU32HFWd https://cassyni.com/events/BghBgoLqYbJ2rUFU32HFWd/abstract https://cassyni-user-files-prod.s3.amazonaws.com/8LnAsz8bTeySB9wrncoC6r https://cassyni.com/events/BghBgoLqYbJ2rUFU32HFWd?videoPreview=1 When Good Research Isn’t Enough: Crafting Impact Narratives That Countnohttps://cassyni.com/events/BghBgoLqYbJ2rUFU32HFWd?videoPreview=12026-08-05T03:00:00+00:005211.8Management and International BusinessOnline seminar – University of Auckland Business School Research impact is more than a good story. A clear, compelling impact narrative can strengthen proposals and submissions, attract collaborators and funders, and act as a practical roadmap for your research. This interactive online seminar brings impact to the forefront of research design. You’ll be introduced to the core principles, concepts and frameworks that underpin powerful impact narratives and discover practical strategies to help you design an impact narrative for your own research that speaks to colleagues, funders, partners and the wider public. Session will cover: · What & why research impact is important · Key principles around research impact · Tips on crafting & using your own impact narrative The session will be facilitated by Professor Swee Mak, Associate Deputy Vice-Chancellor, Research & Innovation Capability, RMIT University (Melbourne, Australia), and is designed to support you in building a more impact-focused research practice. We encourage you to complete a Researcher Impact and Innovation Persona survey before the session. You access the survey through this link: https://www.surveymonkey.com/r/Impactseminar_AU https://cassyni-user-files-prod.s3.amazonaws.com/8LnAsz8bTeySB9wrncoC6r https://cassyni.com/events/5GHxCYSuF127rM1dNnj1pR/abstract https://cassyni-user-files-prod.s3.amazonaws.com/5grK63DqLxqayoPhZrphCS https://cassyni.com/slides/outline/7jXyRxgXSHncDHVBvUdeYM https://cassyni.com/events/7jXyRxgXSHncDHVBvUdeYM/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Ty6v9mQR9nafpP4PCetBx https://cassyni.com/events/CBqznpGKEYXFpyGBe3e8UV/abstract https://cassyni-user-files-prod.s3.amazonaws.com/GQcHX5CwKywTwgTgqSx2MC https://cassyni.com/events/P48uvV1kHydTVincY9pG3w/abstract https://cassyni-user-files-prod.s3.amazonaws.com/WRRSN5eJ5GN4T3vuhzheEi https://cassyni.com/events/SWNHzLsfwDKZgfdqARPyfs/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Jwr8xsLkoDoUjJbPF52rJz https://cassyni.com/events/Q2noPNTQubRz9w7puGUsu7/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Nn5EX4ot2oNeVwJ3h6BnLW https://cassyni.com/slides/outline/2oGutALNGbfVLSsW2kDeRj https://cassyni.com/events/2oGutALNGbfVLSsW2kDeRj/abstract https://cassyni-user-files-prod.s3.amazonaws.com/36wttTHYcdjwJ5aTndowR8 https://cassyni.com/events/2oGutALNGbfVLSsW2kDeRj?videoPreview=1 Mingled Voicesnohttps://cassyni.com/events/2oGutALNGbfVLSsW2kDeRj?videoPreview=12021-08-13T12:00:00+00:00115.04Hong Kong Baptist UniversityThe “Mingled Voices 1-5” event, kindly hosted by the University of Hong Kong Libraries Reading Club, took place on Thursday 15 July 2021. Readings were given by poets whose work appears in the "Mingled Voices" series of poetry anthologies, deriving from the International Proverse Poetry Prize (single poems), now in its sixth edition. The event was moderated by Dr Gillian Bickley, Co-publisher with her husband, Dr Verner Bickley, MBE, of Proverse Hong Kong and Co-founder, also with Verner, of the international Proverse Prizes. The readings were given in two parts. The first group of readings featured poets currently in Hong Kong. The second group featured poets from around the world, present through pre-recorded videos. Among them were many prize-winners.https://cassyni-user-files-prod.s3.amazonaws.com/36wttTHYcdjwJ5aTndowR8 https://cassyni.com/slides/outline/3HvWvqyti4DYLDQPdBWSh3 https://cassyni.com/events/3HvWvqyti4DYLDQPdBWSh3/abstract https://cassyni-user-files-prod.s3.amazonaws.com/KNysoF6QaJkPsS8VzNR6Wi https://cassyni.com/events/3HvWvqyti4DYLDQPdBWSh3?videoPreview=1 What is Happiness?nohttps://cassyni.com/events/3HvWvqyti4DYLDQPdBWSh3?videoPreview=12022-08-31T12:00:00+00:00432.56Hong Kong Baptist UniversityEveryone desires happiness, yet happiness is elusive. What is the nature of Happiness and how can it be attained exactly? In this video, Dr. Mark J. Boone is going to introduce the course "GFVM1036: Happiness: East and West".https://cassyni-user-files-prod.s3.amazonaws.com/KNysoF6QaJkPsS8VzNR6Wi https://cassyni.com/slides/outline/DfYCuCZuvfqxrihXeHTLNZ https://cassyni.com/events/DfYCuCZuvfqxrihXeHTLNZ/abstract https://cassyni-user-files-prod.s3.amazonaws.com/HmhviF9djQPiYuNDBD2jca https://cassyni.com/events/DfYCuCZuvfqxrihXeHTLNZ?videoPreview=1 Philosopher Analyses "Parasite" | Parasite and Marxist Philosophynohttps://cassyni.com/events/DfYCuCZuvfqxrihXeHTLNZ?videoPreview=12022-12-05T12:00:00+00:00452.8Hong Kong Baptist UniversityThis analysis explores the 2019 film *Parasite* through the lens of Marxist philosophy, examining how the material conditions of production shape individual rationality and societal values. The study employs a close reading of Bong Joon-ho's narrative, focusing on the class dynamics between the impoverished Kim family and the wealthy Park family. It is argued that the film subverts traditional portrayals of social class by foregrounding the Kims' struggle for survival in a highly capitalistic Korean society. The Kims' deceptive actions, from fraud to violent assault, are interpreted as a direct consequence of their economic precarity, aligning with Engels' perspective on the choices available to the working class. The analysis highlights how the ruling class's values, as described by Marx, become internalized even by those exploited, leading the Kims to disdain other poor individuals. A central motif, the unassailable "smell" of poverty, demonstrates how class structures persist despite the Kims' talent and hard work, signifying an inherent inferiority in the eyes of the upper class. Ki-taek's climactic act of violence, while testing the Marxist hypothesis of class consciousness and liberation (as discussed by thinkers like Lukács, Fanon, and Foucault), ultimately leads to a bleak conclusion. The film suggests that even a spontaneous revolutionary act fails to liberate the poor, trapping Ki-taek within a metaphorical "iron cage" as described by Weber, thus illustrating the pervasive and inescapable nature of economic determinants on individual agency and societal structures.https://cassyni-user-files-prod.s3.amazonaws.com/HmhviF9djQPiYuNDBD2jca https://cassyni.com/slides/outline/CgEzoqGs3kjpBxsXYJz1Zf https://cassyni.com/events/CgEzoqGs3kjpBxsXYJz1Zf/abstract https://cassyni-user-files-prod.s3.amazonaws.com/7CZPdgx4uuqCYudXXK6QKg https://cassyni.com/events/CgEzoqGs3kjpBxsXYJz1Zf?videoPreview=1 Yoonie Han plays Arirang Concerto (Jisoo Lee) with Collegium Musicum HKnohttps://cassyni.com/events/CgEzoqGs3kjpBxsXYJz1Zf?videoPreview=12021-11-12T12:00:00+00:00181.88Hong Kong Baptist UniversityKorean-American pianist Yoonie Han plays Arirang Concerto (Jisoo Lee) at the Hong Kong City Hall with the Collegium Musicum during Festive Korea, November 2021.https://cassyni-user-files-prod.s3.amazonaws.com/7CZPdgx4uuqCYudXXK6QKg https://cassyni.com/slides/outline/ACzyaR3ErTyKq2Pxzd5Nqj https://cassyni.com/events/ACzyaR3ErTyKq2Pxzd5Nqj/abstract https://cassyni-user-files-prod.s3.amazonaws.com/6HX8vqJ8v4pakwed9T67yp https://cassyni.com/events/ACzyaR3ErTyKq2Pxzd5Nqj?videoPreview=1 Touring Ottoman Lands: Murray's Routes for Southwest Asianohttps://cassyni.com/events/ACzyaR3ErTyKq2Pxzd5Nqj?videoPreview=12024-12-22T12:00:00+00:001718.84Hong Kong Baptist UniversityDuring the 19th century, major developments in transportation and the broad distribution of travel literature reshaped the principles of global travel, marking this period as a pivotal moment in the evolution of tourism. Within this context, the Ottoman Empire emerged as a prominent destination for the burgeoning tourist classes. Guidebooks, notably John Murray's Handbooks for Travellers, played a crucial role in structuring and refining the tourist experience, offering curated routes and comprehensive descriptions of key destinations. Through a diachronic visualization, the project aims to present a comprehensive look at the evolving tourist landscapes within the Ottoman Empire and beyond in Southwest Asia during the second half of the 19th century.https://cassyni-user-files-prod.s3.amazonaws.com/6HX8vqJ8v4pakwed9T67yp https://cassyni.com/slides/outline/M4qvt1YVU8Fu9qC8Mod765 https://cassyni.com/events/M4qvt1YVU8Fu9qC8Mod765/abstract https://cassyni-user-files-prod.s3.amazonaws.com/75RSvkpAQajE7HKamvgKNn https://cassyni.com/events/M4qvt1YVU8Fu9qC8Mod765?videoPreview=1 The Battle of Hong Kong in 1941nohttps://cassyni.com/events/M4qvt1YVU8Fu9qC8Mod765?videoPreview=12021-11-05T12:00:00+00:005380.28Hong Kong Baptist UniversityThis talk introduces our spatial history project “Hong Kong 1941,” which uses geographic information systems (GIS) to build an interactive web map about the Battle of Hong Kong and a database of British military installations in Hong Kong during the Second World War. It offers an easy-to-use historical database for educators, tourists, and conservation professionals. There have been numerous studies on the Battle of Hong Kong in 1941; in recent years, more primary sources are available in the form of the memoirs of those who had experienced it. However, it has been a challenge for researchers to show the spatial and temporal dimensions of the battle and their relationship with the events, the people’s experience, and the war ruins that still exist in Hong Kong. The spatial history project “Hong Kong 1941” tries to tackle such a challenge and aims to bridge the gaps that existed between the British and Japanese accounts to offer a clearer view of the battle and to show the diverse experiences of the combatants and the civilians during the eighteen days of fighting. It also serves as a platform where stories often overlooked by war narratives are exhibited in conjunction with the major events.https://cassyni-user-files-prod.s3.amazonaws.com/75RSvkpAQajE7HKamvgKNn https://cassyni.com/slides/outline/RWgNJANDRFF9cUwvGTPgEZ https://cassyni.com/events/RWgNJANDRFF9cUwvGTPgEZ/abstract https://cassyni-user-files-prod.s3.amazonaws.com/WSGVV1dLH4QWQwCzhwgPQS https://cassyni.com/events/RWgNJANDRFF9cUwvGTPgEZ?videoPreview=1 Dogmatic Authoritynohttps://cassyni.com/events/RWgNJANDRFF9cUwvGTPgEZ?videoPreview=12025-07-12T12:00:00+00:005637.48Hong Kong Baptist UniversityPat is joined by Fr. James Dominic Rooney to discuss some of his recent work on dogmatic authority and the logic of infallibility. They also touch a bit on the question (yes, again!) of whether Christians and Muslims worship the same God.https://cassyni-user-files-prod.s3.amazonaws.com/WSGVV1dLH4QWQwCzhwgPQS https://cassyni.com/slides/outline/PY5x7Rn7fR2PWmfguVXjp1 https://cassyni.com/events/PY5x7Rn7fR2PWmfguVXjp1/abstract https://cassyni-user-files-prod.s3.amazonaws.com/K4CbXbHQrf13xLunBGWdxa https://cassyni.com/events/PY5x7Rn7fR2PWmfguVXjp1?videoPreview=1 Industrial Production in the Ancient World: Bronze Mirrors and Bells in Chinanohttps://cassyni.com/events/PY5x7Rn7fR2PWmfguVXjp1?videoPreview=12024-11-15T12:00:00+00:005120.48Hong Kong Baptist UniversityThis study examines the industrial production of bronze mirrors and bells in ancient China, arguing for the existence of an industrial revolution around 500 BCE marked by large-scale, efficient replication techniques. The analysis focuses on the manufacturing processes underlying these artifacts, emphasizing the transition from a pre-500 BCE system—where one model produced a single bronze object—to a post-500 BCE system characterized by multiple identical molds derived from a single decorated model. Detailed comparative examinations of decorative patterns on bronze mirrors from various East Asian sites reveal identical motifs and “fingerprint” granularity, indicating sophisticated replication through successive transfers between component models, pad models, and molds. This multi-stage production involved a division of labor and assembly-line methods aimed at maximizing efficiency and material conservation, including the reuse of trimmed mold fragments. The study also extends to bronze bells, highlighting their unique acoustic properties achieved through precise replication and mold-core configurations verified by 3D model superimposition. The findings demonstrate that ancient Chinese artisans employed complex, systematic manufacturing principles—power, accuracy, economy, continuity, and speed—well before modern industrialization. This industrial capacity facilitated mass production that supported territorial control, culminating in the Han Empire’s expansion. The research underscores the intellectual sophistication and sustainable practices of ancient Chinese metallurgy, challenging assumptions about technological primitiveness and offering a framework for understanding early industrial arts through archaeological and digital methodologies.https://cassyni-user-files-prod.s3.amazonaws.com/K4CbXbHQrf13xLunBGWdxa https://cassyni.com/slides/outline/L5YineFSbD9kV5N8Fq9nHB https://cassyni.com/events/L5YineFSbD9kV5N8Fq9nHB/abstract https://cassyni-user-files-prod.s3.amazonaws.com/WFKVB6AeEDaJenkUEGP8Na https://cassyni.com/events/L5YineFSbD9kV5N8Fq9nHB?videoPreview=1 China's Cloud Control in the Shadows of Ecological Civilizationnohttps://cassyni.com/events/L5YineFSbD9kV5N8Fq9nHB?videoPreview=12022-04-30T12:00:00+00:001258.24Hong Kong Baptist UniversityWilliam Burroughs in “The Limits of Control” points out that there is always an implicit impasse in all control systems: control mechanism needs opposition that it cannot completely control; when there is no more opposition, and when control is complete, the fulfilment would render the system meaningless. There is nothing more incomplete or unfulfilling than weather control, which is called geoengineering, a technology that helps human to modify and manipulate the weather. For decades, China has been investing heavily in this technology, resulting with owning one of the world’s most advanced weather modification programs, even though the definitive scientific evidence for the efficacy of cloud seeding, rainmaking, rain-suppression, or hail-suppression remains debatable and undetermined. China’s geoengineering endeavours do not only reveal the authorities’ plans to control the clouds in order to regulate the weather, but also their desire to take the form of the clouds by assuming a privileged, transcendent vantage point up in the sky over the world (the fantasy of political elite to play god by seeing the world in its entirety objectively, understanding the real and explaining all). The state project of ecological civilization emerged as a top-down model built upon the Chinese socialist ideologies with the emphasis on the mutual compatibility of economic growth, environmental sustainability and social justice. The top-down, nontransparent, and non-participatory policies single-mindedly pursue the stipulated objectives but may possibly create second-order problems and unintended cloudy consequences, other than designating the parallel universe of the political leaders’ cloud perspectives and the world on the ground. The image or metaphor of the clouds is also manifested in China’s determination to monitor the cloud computing industry. For competitive and governance reasons, Beijing is eager to bolster the capabilities of Chinese cloud companies, like Alibaba Cloud, Huawei and Tencent. After all, surveillance technologies and digital security rely upon an efficient cloud system. While cloud computing promises the dematerialization of data storage and the ubiquitous connectivity of frictionless computation in all spaces, its nature and infrastructure cannot be obfuscated as shapeless, amorphous clouds but remains as stratified grid-network constructions and data hubs on some real location that require immense amounts of power to keep them running and are simultaneously emitting carbon dioxide. By no means is China as an authoritarian country the only state in the world that manipulates the clouds in terms of modifying weather and doing digital surveillance. But China serves as a good model, not only given its sheer size, growth rate and volatile situation, to examine how the combination of geoengineering and digital technologies impacts on cloud control. Clouds could mean both connection and isolation, as if China wants global trade and economic self-sufficiency at the same time. But the paradox is in order to make cloud control effective, no one can isolate one cloud from another. Etymologically, control means stopping the roll or the wheel. As long as there’s no way to stop cloud rolling, control can never succeed but is self-motivated to perpetuate.https://cassyni-user-files-prod.s3.amazonaws.com/WFKVB6AeEDaJenkUEGP8Na https://cassyni.com/slides/outline/WTAQkzqTopnB1afGGw6fxh https://cassyni.com/events/WTAQkzqTopnB1afGGw6fxh/abstract https://cassyni-user-files-prod.s3.amazonaws.com/8JwSf9vkMLbNDWARjkt2Tp https://cassyni.com/events/WTAQkzqTopnB1afGGw6fxh?videoPreview=1 Faith in the midst of pandemicnohttps://cassyni.com/events/WTAQkzqTopnB1afGGw6fxh?videoPreview=12020-05-16T12:00:00+00:001977.4Hong Kong Baptist UniversityThe widespread COVID-19 pandemic presents significant challenges to faith, prompting questions about suffering, divine intention, and the nature of evil. This analysis develops a three-step framework for defending faith in such situations: knowing the content of one's faith, discerning the current circumstances, and applying faith practically. Theologically, faith is anchored in God's unchanging goodness, which is identified as the source of all good and perfect gifts, not unjustified evil. The study distinguishes four categories of evil: divine judgment, natural/physical occurrences, demonic forces, and man-made evil (including moral transgressions, human errors, and environmental pollution). Through this discernment, the current pandemic is characterized primarily as a largely man-made phenomenon, stemming from factors such as its origin in a Wuhan wet market, initial misinformation, global travel, and widespread disregard for health advisories. This perspective differentiates it from biblical prophecies of divine judgment, which are described as inescapable. The analysis concludes by affirming confidence in God's sovereignty and purpose, advocating for the practical application of faith. This involves cultivating wisdom, making efficient use of time, understanding divine will, avoiding debauchery, being filled with the Spirit, engaging in spiritual praise, worshipping incessantly, expressing continuous gratitude, and practicing mutual submission, as outlined in Ephesians 5:15-21. Adherence to these principles enables believers to navigate adversity, strengthen their faith, and respond to others' inquiries regarding hope.https://cassyni-user-files-prod.s3.amazonaws.com/8JwSf9vkMLbNDWARjkt2Tp https://cassyni.com/slides/outline/Wwp1ogUzFHLE1MC9sNPUE1 https://cassyni.com/events/Wwp1ogUzFHLE1MC9sNPUE1/abstract https://cassyni-user-files-prod.s3.amazonaws.com/GizkJkGf4znXaR1m1hrgEA https://cassyni.com/events/Wwp1ogUzFHLE1MC9sNPUE1?videoPreview=1 User Generated Content: Aesthetics of Enclosed Creativitynohttps://cassyni.com/events/Wwp1ogUzFHLE1MC9sNPUE1?videoPreview=12020-08-29T12:00:00+00:00930.48Hong Kong Baptist UniversityUser-generated content (UGC) and Web 2.0 models are transforming relationships with creative software, yielding aesthetic outcomes often underexplored by art historians. This study investigates the aesthetics of "enclosed creativity," focusing on works made within proprietary game engines and creative game sandboxes. These creations, exemplified by platforms such as Garry's Mod (over 15 million copies sold), Minecraft (69 million copies), and Dreams (over 35,000 player creations within six months), represent a significant, yet often overlooked, creative practice at the intersection of software development and platform capitalism. The research employs a hermeneutic analysis of creative game sandboxes, particularly Media Molecule’s Dreams. It examines the technical history of game modification and cinematic practices, alongside the dynamic interplay between legal restrictions, such as license agreements, and user demands, which shapes a "media hybrid" as conceptualized by Lawrence Lessig. This collision of copyright enforcement with user-driven remixing practices is identified as a fundamental aesthetic consideration, aligning with "database aesthetics" and post-production culture. Three tentative aesthetic features of enclosed creativity are identified: claustrophobia, repetition, and redundancy. Claustrophobia manifests in the inherent challenges of overcoming platform defaults and the filter-bubble effect of content recommendations. Repetition is evident in the constant recreation of cultural fragments and recurring discourse surrounding intellectual property disputes. Redundancy highlights the ephemeral nature of individual creations within proprietary systems, which is historically balanced by their repetitive recreation across new platforms. This framework contributes to the aesthetic study of game modifications and informs planned empirical research.https://cassyni-user-files-prod.s3.amazonaws.com/GizkJkGf4znXaR1m1hrgEA https://cassyni.com/slides/outline/6FPoVW8kJPeGqtuRM9oNYM https://cassyni.com/events/6FPoVW8kJPeGqtuRM9oNYM/abstract https://cassyni-user-files-prod.s3.amazonaws.com/6Z6xxq2auWH65bmmLNKnB8 https://cassyni.com/events/6FPoVW8kJPeGqtuRM9oNYM?videoPreview=1 Grolier Hybrid Reading — James Shea and Dorothy Tse reading the poems of Yam Gongnohttps://cassyni.com/events/6FPoVW8kJPeGqtuRM9oNYM?videoPreview=12022-06-22T12:00:00+00:002263.56Hong Kong Baptist UniversityBorn in 1949, Yam Gong, the pen name of Lau Yee-ching, is a celebrated Hong Kong poet whose honors include the Hong Kong Youth Literature Award, the Work- ers’ Literature Award, and the Hong Kong Biennial Award for Chinese Literature for his first book And So You Look at Festival Lights along the Street (1997). He later published an extended edition of this collection, titled And So Moving a Stone You Look at Festival Lights along the Street (2010).https://cassyni-user-files-prod.s3.amazonaws.com/6Z6xxq2auWH65bmmLNKnB8 https://cassyni.com/slides/outline/Jum2ffVup7FSoC5Lg6NpD https://cassyni.com/events/Jum2ffVup7FSoC5Lg6NpD/abstract https://cassyni-user-files-prod.s3.amazonaws.com/UikgucmvchUjsCQfihcEYn https://cassyni.com/events/Jum2ffVup7FSoC5Lg6NpD?videoPreview=1 Behind The Way We Talk: Deaf Culture & Film Talk w/ Director Adam Wongnohttps://cassyni.com/events/Jum2ffVup7FSoC5Lg6NpD?videoPreview=12025-06-14T12:00:00+00:00791.16Hong Kong Baptist UniversityA soul-searching story about three friends, Wolf, Alan and Sophie, who have different conditions of deafness. When Sophie graduates from the university and starts a new job, she realises she has been struggling to be seen as normal. Tensions grow between the three friends as they find themselves conflicting over how best to communicate with the world while remaining true to themselves.https://cassyni-user-files-prod.s3.amazonaws.com/UikgucmvchUjsCQfihcEYn https://cassyni.com/slides/outline/8idpivNNVgQmCqNytqi1GH https://cassyni.com/events/8idpivNNVgQmCqNytqi1GH/abstract https://cassyni-user-files-prod.s3.amazonaws.com/bmfcjWZdxqQCYycdAvZTc https://cassyni.com/events/8idpivNNVgQmCqNytqi1GH?videoPreview=1 Regarding Racismnohttps://cassyni.com/events/8idpivNNVgQmCqNytqi1GH?videoPreview=12021-06-16T12:00:00+00:006566.16Hong Kong Baptist UniversityRace, a permanent feature of Singapore’s social relations, has stepped out from the shadows, demanding the nation’s attention. A string of social media videos exposing people’s intolerance and hate has sparked widespread revulsion. But there is much less agreement about what these incidents mean. Can they be dismissed as extreme outliers or are they representative of wider rifts? Does the problem start and end with errant individuals, or is it time to refine Singapore’s approaches to ethnic identity? Do they reveal the need for more open conversations — or that the less said, the better? This roundtable gathers scholars of anthropology, sociology, politics and literature for a multidisciplinary conversation about how concerned citizens might think about race and respond to racism.https://cassyni-user-files-prod.s3.amazonaws.com/bmfcjWZdxqQCYycdAvZTc https://cassyni.com/slides/outline/6mBwDzucFeBAYtRkGgLfnm https://cassyni.com/events/6mBwDzucFeBAYtRkGgLfnm/abstract https://cassyni-user-files-prod.s3.amazonaws.com/ANVMzAsi7qaZAJiXW5tL3g https://cassyni.com/events/6mBwDzucFeBAYtRkGgLfnm?videoPreview=1 High-Order Implicit Large Eddy Simulation of Flow over a Low-Reynolds Turbine Cascadenohttps://cassyni.com/events/6mBwDzucFeBAYtRkGgLfnm?videoPreview=12021-07-15T14:00:00+00:003510.08PyFRIn the present study scale-resolving simulations of flow over a low-Reynolds turbine cascade are performed using PyFR. Various flow metrics, including isentropic Mach number distribution at mid-span and total pressure loss in the wake are compared against experimental data for two different Reynolds-numbers. The good agreement of th results and experimental data demonstrate the potential of PyFR specially as a GPU-accelerated CFD tool for simulating unsteady flows on unstructured meshes. Moreover a detailed analyze of the influence of turbulent inflow and different Reynolds-numbers on the separation, laminar-turbulent transition and total pressure wake loss is presented.https://cassyni-user-files-prod.s3.amazonaws.com/ANVMzAsi7qaZAJiXW5tL3g https://cassyni.com/events/K7RfVibcdSx2eMwJ2DCDFB/seminar/qa https://cassyni.com/slides/outline/K7RfVibcdSx2eMwJ2DCDFB https://cassyni.com/events/K7RfVibcdSx2eMwJ2DCDFB/abstract https://cassyni-user-files-prod.s3.amazonaws.com/HQb41rnGYYN6BrReLD7eRk https://cassyni.com/events/K7RfVibcdSx2eMwJ2DCDFB?videoPreview=1 Precision calculations in the MSSM Higgs sector with FeynHiggsnohttps://cassyni.com/events/K7RfVibcdSx2eMwJ2DCDFB?videoPreview=12021-06-29T15:00:00+00:003055.44Computer Physics CommunicationsIn this talk I will give an overview of the status and recent developments of the FeynHiggs code. The main purpose of FeynHiggs is to calculate the Higgs boson masses and other physical observables in the Minimal Supersymmetric Standard Model (MSSM). To obtain an accurate prediction of the Higgs boson masses for low and high supersymmetry scales, state-of-the-art fixed-order and effective-field-theory calculations are combined. FeynHiggs provides not only a prediction for the Higgs boson masses, but also an estimate for the remaining theoretical uncertainties. I will highlight some of the recent improvements in the effective field theory calculation that are relevant for a light Higgs boson mass spectrum and in the presence of CP-violating phases. Finally, I will point out some exemplary phenomenological studies using FeynHiggs to constrain the MSSM Higgs sector.https://cassyni-user-files-prod.s3.amazonaws.com/HQb41rnGYYN6BrReLD7eRk https://cassyni.com/slides/outline/phtmASMs4e99niQGCdg4d https://cassyni.com/events/phtmASMs4e99niQGCdg4d/abstract https://cassyni-user-files-prod.s3.amazonaws.com/9w177z1iuCi4FBw4VVKW8e https://cassyni.com/events/phtmASMs4e99niQGCdg4d?videoPreview=1 Evaluating sheep as a large animal model in hearing & balance researchnohttps://cassyni.com/events/phtmASMs4e99niQGCdg4d?videoPreview=12021-05-11T04:00:00+00:002728.6The Auckland Bioengineering InstituteBioengineers WANTED! In this talk, we will share our ongoing research work and highlight some challenges in the field in hope to hear innovative solutions from ABI! Hearing loss affects 1.5 Billion people worldwide, majority of this caused by pathologies in the inner ear. There is no treatment that can effectively prevent or reverse the inner ear pathology. Key limitation in the field is the lack of clinical tools to deliver drugs to the inner ear, or to diagnose the inner ear pathologies of individual cases. We hope to contribute to solving these limitations by establishing the sheep as a large animal preclinical model suitable for developing new clinical tools for inner ear therapeutics. The aim of this study was to characterize the aspects of sheep cochlea to allow us to make comparison to those of human and rodents. We have combined imaging modalities (confocal microscopy, MRI and microCT) to characterized the geometry of cochlea and vestibular systems of sheep with the most focus on the round window, the membrane-covered opening and the presumed path for therapeutic agent to enter the cochlea. We are now using the sheep as the model platform to develop new drug delivery methodology. https://cassyni-user-files-prod.s3.amazonaws.com/9w177z1iuCi4FBw4VVKW8e https://cassyni.com/slides/outline/3JjaF6vbPX5ccVGncMbupR https://cassyni.com/events/3JjaF6vbPX5ccVGncMbupR/abstract https://cassyni-user-files-prod.s3.amazonaws.com/5H4oDzQM9Kdf4x2LiQmbRx https://cassyni.com/events/3JjaF6vbPX5ccVGncMbupR?videoPreview=1 Foreign, illegal prostitutes’: migrant sex work and the media, Building the body as a site of pleasure: Contributions from embodied sociolinguisticsnohttps://cassyni.com/events/3JjaF6vbPX5ccVGncMbupR?videoPreview=12020-11-13T16:00:00+00:003932.32Linguistics and Applied Language StudiesIn 2003, New Zealand decriminalised sex work, a hard-fought win for a stigmatised group. However, people on temporary visas can still be deported for selling sex. This presentation considers how the media constructs migrant sex workers in ways that contribute to this discrimination. Using a corpus of news articles under a critical discourse framework, I offer quantitative and qualitative insights into this question, highlighting the way the law is used to perpetuate anti-migrant and whorephobic Discourses in supposedly progressive New Zealand. Talking about women's erotic pleasure is politically powerful because it directly challenges patriarchal hostility toward female sexual agency. This presentation explores the ways in which sexual pleasure dynamically unfolds in the discursive construction of the body. Using a lens of embodied sociolinguistics, I show how experiences of sexual pleasure are negotiated in talk between female friends, and how individuals learn, teach and come to know each other’s bodies. This leads to a critical mapping of bodies as construction sites across time and space, building an extension into contemporary theorizing about bodies and language.https://cassyni-user-files-prod.s3.amazonaws.com/5H4oDzQM9Kdf4x2LiQmbRx https://cassyni.com/slides/outline/L6ojvySKiSqT7Hxnmvsejf https://cassyni.com/events/L6ojvySKiSqT7Hxnmvsejf/abstract https://cassyni-user-files-prod.s3.amazonaws.com/J8APYdhHXRqWxDFMc1XfSE https://cassyni.com/events/L6ojvySKiSqT7Hxnmvsejf?videoPreview=1 Conceptual-based design of ultra-broadband microwave metamaterial absorbernohttps://cassyni.com/events/L6ojvySKiSqT7Hxnmvsejf?videoPreview=12021-05-04T14:00:00+00:003471.16MetaMATBy introducing metallic-ring structural resonances in the microwave regime, we have designed and realized a metamaterial absorber with hierarchical structures that can display an averaged -19.4 dB reflection loss from 3-40 GHz. The overall thickness of the sample is 14.2 mm, only 5% over the minimum thickness dictated by the causality limit. The measured performance is polarization-independent at normal incidence, while absorption at oblique incidence remains considerably effective up to 45 degrees. We provide a conceptual basis for our absorber design, based on the magnetically-excited, two-dimensional capacitive-coupled (electrical) dipolar resonances in the lateral plane, coupled to the standing wave along the incident wave direction. To realize broadband impedance matching, we use a metallic boundary to split the dipolar resonance into two resonances, and add resistors so as to maximize dissipation over the frequency range in-between the two split resonances. To further extend the absorption spectrum to an ultra-broadband range, we employ a double-layer self-similar structure, in conjunction with the absorption of the diffracted waves at the higher end of the frequency spectrum. The resulting microwave absorber pushes the overall performance close to the causality limit, while simultaneously possesses a large relative absorption bandwidth.https://cassyni-user-files-prod.s3.amazonaws.com/J8APYdhHXRqWxDFMc1XfSE https://cassyni.com/slides/outline/WURRuL2Lw4TsdoFvo2pYRB https://cassyni.com/events/WURRuL2Lw4TsdoFvo2pYRB/abstract https://cassyni-user-files-prod.s3.amazonaws.com/LiZp3Dqnq5k2jQ3hH5jRo4 https://cassyni.com/events/WURRuL2Lw4TsdoFvo2pYRB?videoPreview=1 Acoustic Metamaterial Wizardrynohttps://cassyni.com/events/WURRuL2Lw4TsdoFvo2pYRB?videoPreview=12020-12-01T14:00:00+00:007868.16MetaMATAcoustic metamaterials are non-naturally occurring structures consisting of arrays of sub-wavelength resonators designed to manipulate the propagation of sound, exhibiting effective negative density or modulus [1,2]. Counterintuitive metamaterial properties such as acoustic negative refraction, superlensing and cloaking have been demonstrated. Another example is extraordinary acoustic transmission, i.e. the passage of more acoustic energy than expected through a small sub-acoustic-wavelength aperture acting as an acoustic meta-atom. This has been be demonstrated in a variety of systems, having first been shown in optics. I will first present our experimental work in this field using kHz airborne acoustics [3], in which case we find giant transmission, with enhancements up to ~60, by use of an aperture closed with a membrane. I will then show how gigantic transmission enhancement, by more than a factor of 500, can be achieved in solid acoustics [4,5]. Closely related to extraordinary acoustic transmission is the phenomenon of enhanced transmission between acoustically mismatched media. I will review experimental work on the enormously enhanced passage of acoustic waves from water to air based on the use of a kHz acoustic metasurface [6]. Finally, I will present recent kHz experiments on acoustic metabeams [7] and metarods [8] with perfect bandgaps that prevent all vibrations from passing along them at certain frequencies. The era of metawands that do not vibrate is upon us.https://cassyni-user-files-prod.s3.amazonaws.com/LiZp3Dqnq5k2jQ3hH5jRo4 https://cassyni.com/slides/outline/Wy52x1fsNX1vdZnpPU7LgV https://cassyni.com/events/Wy52x1fsNX1vdZnpPU7LgV/abstract https://cassyni-user-files-prod.s3.amazonaws.com/QJGSdBHM1ekjrZSFyEJFF4 https://cassyni.com/events/Wy52x1fsNX1vdZnpPU7LgV?videoPreview=1 Manipulating water waves using bathymetric plate arraysnohttps://cassyni.com/events/Wy52x1fsNX1vdZnpPU7LgV?videoPreview=12021-10-19T14:00:00+00:005519.56MetaMATThis talk will describe how closely-spaced arrays of vertical plates protruding from the bed of an incompressible fluid can be used to produce interesting effects on water waves propagating on the surface of the fluid. We will consider how both fully depth dependent and depth-averaged (shallow water) models are formulated and how they compare and illustrate their use in a number of different settings. For instance, we can generate examples of bathymetric devices which represent all-frequency all-angle refractive devices which allow negative refraction and for which the phase velocity is directed towards the source. Other examples include the use of bathymetric plate arrays to perfectly transmit energy through bends in waveguides and, when formed into a cylinder, act as a bathymetric lens.https://cassyni-user-files-prod.s3.amazonaws.com/QJGSdBHM1ekjrZSFyEJFF4 https://cassyni.com/slides/outline/ADp2tfywXvqQ7JGMyoAqy7 https://cassyni.com/events/ADp2tfywXvqQ7JGMyoAqy7/abstract https://cassyni-user-files-prod.s3.amazonaws.com/7fTQcJvzEX6x2YRSC9T9bU https://cassyni.com/events/ADp2tfywXvqQ7JGMyoAqy7?videoPreview=1 Gradient estimates for the insulated conductivity problemnohttps://cassyni.com/events/ADp2tfywXvqQ7JGMyoAqy7?videoPreview=12020-11-02T15:00:00+00:003202.0Partial Differential Equations and ApplicationsIn this talk, we discuss the insulated conductivity problem with multiple inclusions embedded in a bounded domain in n-dimensional Euclidean space. The gradient of a solution may blow up as two inclusions approach each other. The optimal blow up rate was known in dimension n=2. It was not known whether the established upper bound of the blow up rates in higher dimensions were optimal. We answer this question by improving the previously known upper bound of the blow up rates in dimension n > 2. This is a joint work with Zhuolun Yang.https://cassyni-user-files-prod.s3.amazonaws.com/7fTQcJvzEX6x2YRSC9T9bU https://cassyni.com/events/TWWBWbdJtxDWnB2dY8uDEm/seminar/qa https://cassyni.com/slides/outline/TWWBWbdJtxDWnB2dY8uDEm https://cassyni.com/events/TWWBWbdJtxDWnB2dY8uDEm/abstract https://cassyni-user-files-prod.s3.amazonaws.com/BFDH4CgWaLUixt5VHM6hXk https://cassyni.com/events/TWWBWbdJtxDWnB2dY8uDEm?videoPreview=1 Traveling waves for nonlinear wave equationsnohttps://cassyni.com/events/TWWBWbdJtxDWnB2dY8uDEm?videoPreview=12021-12-09T14:00:00+00:002245.88Partial Differential Equations and ApplicationsLocal, classical traveling waves can serve as building blocks for global traveling waves by gluing them together. We will illustrate for both the Camassa-Holm and the nonlinear variational wave equation, how this can be done by using ideas from scalar conservation laws. In addition, we will highlight that some traveling waves do not belong to the most prominent set of solutions and hence cannot be obtained by classical methods when solving the Cauchy problem with a traveling wave profile as initial data.https://cassyni-user-files-prod.s3.amazonaws.com/BFDH4CgWaLUixt5VHM6hXk https://cassyni.com/slides/outline/LAnAzrP33nx51njrmpFGh https://cassyni.com/events/LAnAzrP33nx51njrmpFGh/abstract https://cassyni-user-files-prod.s3.amazonaws.com/UuLPbhkZ7CuXLnD3R5PdFt https://cassyni.com/events/LAnAzrP33nx51njrmpFGh?videoPreview=1 Self-collimation, Veselago lens, Dirac cones and embedded states in continuum in acoustics without phononic crystals and metamaterialsnohttps://cassyni.com/events/LAnAzrP33nx51njrmpFGh?videoPreview=12021-10-26T14:00:00+00:005740.76MetaMATThe concepts of photonic crystals and metamaterials initially appeared in optics and electromagnetism, and were subsequently extended to acoustic waves. However, a number of phenomena thought to be specific to these “artificial” media have been observed in solid state acoustics with conventional materials – in some cases well before the advent of metamaterials and photonic/phononic crystals. In this talk, which will cover both historical and recent research, we will discuss several such phenomena: (i) “self-collimation” of bulk and surface acoustic waves in natural crystals; (ii) negative group velocity, Veselago lens and Dirac cones exhibited by guided acoustic waves in plates; (iii) robust embedded states in continuum on natural crystal surfaces and in simple layered structures.https://cassyni-user-files-prod.s3.amazonaws.com/UuLPbhkZ7CuXLnD3R5PdFt https://cassyni.com/slides/outline/RXwPSVZ6YUvrEhYanZ7Yh3 https://cassyni.com/events/RXwPSVZ6YUvrEhYanZ7Yh3/abstract https://cassyni-user-files-prod.s3.amazonaws.com/AWFXMRT4TyiZvf6ATMu126 https://cassyni.com/events/RXwPSVZ6YUvrEhYanZ7Yh3?videoPreview=1 Can a butterfly in Brazil control the climate of Texas?nohttps://cassyni.com/events/RXwPSVZ6YUvrEhYanZ7Yh3?videoPreview=12020-10-28T14:00:00+00:003386.64Department of AeronauticsThe butterfly effect is a well-known phenomenon in fluid dynamics. A small perturbation to a chaotic dynamical system, such as turbulent flows or the Earth’s atmosphere, can lead to large differences at a later time. Lorenz famously posed the question, does the flap of a butterfly’s wings in Brazil set off a tornado in Texas? The answer is now widely accepted to be yes. This result has significant consequences to simulations that resolve chaotic dynamics in aerodynamic flows. Whereas a tiny perturbation can change the state of a chaotic system, it is unclear whether it can change the long-time statistics. Statistics of many turbulent flows are known to be stable, insensitive to initial conditions. Ergodic theory provided a foundation for such stability. If the weather is ergodic, then it seems unlikely that the butterfly in Brazil can affect the long-time statistics of weather, also known as the climate of Texas. Indeed, for many scale-resolved aerodynamic simulations to be meaningful, we must believe that their statistics are not super sensitive to perturbations such as numerics and modeling approximations. The concept and theory of shadowing in dynamical systems support such claims for stability. The speaker, having dedicated almost a decade of research into the theory and computation of shadowing, has recently found the approach insufficient. Even systems that satisfy most idealized assumptions in shadowing theory can be arbitrarily sensitive to parameter perturbations. This question thus resurfaces: can a butterfly in Brazil change the climate of Texas? In this talk, we will illustrate why the theory of shadowing cannot give a negative answer to this question. We will then construct a simple mathematical model in which arbitrarily small perturbations can significantly influence the statistics of a stable, ergodic system. In Lorenz’s analogy, a sufficiently intelligent butterfly could wield robust control over the climate. While still seeking an answer to the question in the title for realistic flow physics, we emphasize its importance to aerodynamics and control. If the answer is yes, we must question whether we can trust any numerical or laboratory simulation in predicting the statistics of chaotic aerodynamics, even if numerics and modeling can be made arbitrarily precise. A positive answer also reveals an opportunity to control the statistics of large and powerful chaotic flows with tiny and even imperceptible control actions.https://cassyni-user-files-prod.s3.amazonaws.com/AWFXMRT4TyiZvf6ATMu126 https://cassyni.com/slides/outline/BD8s6fnspCsGvXnmNLacQd https://cassyni.com/events/BD8s6fnspCsGvXnmNLacQd/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Bs2wEJUkfzEnr9tVwVFijg https://cassyni.com/events/BD8s6fnspCsGvXnmNLacQd?videoPreview=1 Deep Learning of Conjugate Mappingsnohttps://cassyni.com/events/BD8s6fnspCsGvXnmNLacQd?videoPreview=12022-02-03T13:00:00+00:002877.88Department of AeronauticsDespite many of the most common chaotic dynamical systems being continuous in time, it is through discrete time mappings that much of the understanding of chaos is formed. Henri Poincaré first made this connection by tracking consecutive iterations of the continuous flow with a lower-dimensional, transverse subspace. The mapping that iterates the dynamics through consecutive intersections of the flow with the subspace is now referred to as a Poincaré map, and it is the primary method available for interpreting and classifying chaotic dynamics. Unfortunately, in all but the simplest systems, an explicit form for such a mapping remains outstanding. In this talk I present a method of discovering explicit Poincaré mappings using deep learning to construct an invertible coordinate transformation into a conjugate representation where the dynamics are governed by a relatively simple chaotic mapping. The invertible change of variable is based on an autoencoder, which allows for dimensionality reduction, and has the advantage of classifying chaotic systems using the equivalence relation of topological conjugacies. We illustrate with low-dimensional systems such as the Rössler and Lorenz systems, while also demonstrating the utility of the method on the infinite-dimensional Kuramoto-Sivashinsky equation. https://cassyni-user-files-prod.s3.amazonaws.com/Bs2wEJUkfzEnr9tVwVFijg https://cassyni.com/slides/outline/ManBBetnSBRRbWnJg1Twim https://cassyni.com/events/ManBBetnSBRRbWnJg1Twim/abstract https://cassyni-user-files-prod.s3.amazonaws.com/BjsXy8ZsZd6mRuZip6xb6n https://cassyni.com/events/ManBBetnSBRRbWnJg1Twim?videoPreview=1 Modelling and controlling turbulent flows through deep learningnohttps://cassyni.com/events/ManBBetnSBRRbWnJg1Twim?videoPreview=12022-04-12T15:00:00+00:003343.36Department of AeronauticsThe advent of new powerful deep neural networks (DNNs) has fostered their application in a wide range of research areas, including more recently in fluid mechanics. In this presentation, we will cover some of the fundamentals of deep learning applied to computational fluid dynamics (CFD). Furthermore, we explore the capabilities of DNNs to perform various predictions in turbulent flows: we will use convolutional neural networks (CNNs) for non-intrusive sensing, i.e. to predict the flow in a turbulent open channel based on quantities measured at the wall. We show that it is possible to obtain very good flow predictions, outperforming traditional linear models, and we showcase the potential of transfer learning between friction Reynolds numbers of 180 and 550. We also discuss other modelling methods based on autoencoders (AEs) and generative adversarial networks (GANs), and we present results of deep-reinforcement-learning-based flow control.https://cassyni-user-files-prod.s3.amazonaws.com/BjsXy8ZsZd6mRuZip6xb6n https://cassyni.com/slides/outline/XTkG7KqHDLVkT2nLBaEJrh https://cassyni.com/events/XTkG7KqHDLVkT2nLBaEJrh/abstract https://cassyni-user-files-prod.s3.amazonaws.com/JTfPx6HcYrUWbtzVx4NBXL https://cassyni.com/events/XTkG7KqHDLVkT2nLBaEJrh?videoPreview=1 From Dropwise 3D-Printing to icephobic feathers of penguins: Spreading and arrest near moving contact line during solidificationnohttps://cassyni.com/events/XTkG7KqHDLVkT2nLBaEJrh?videoPreview=12022-04-27T16:00:00+00:003656.16Department of Chemical EngineeringSpreading of liquid drop on cold solid substrates is a complicated problem that involves heat transfer, fluid dynamics, and phase change physics with the combination of complex wetting behavior of contact line. Many researchers are trying to obtain the final shape of the droplet or in other words the contact angle and radius of the drop after the solidification is complete. Understanding the physics behind the non-isothermal spreading of droplet is of utmost importance owing to its broad applications in diverse areas of industry in particular in 3D printing application. This work mainly focuses on obtaining important physical parameters involved in the process of spreading of molten droplets as well as controlling the post-solidification geometry of droplets. A complete set of experimental study is performed that shows the final radius in the case of free fall of droplet under high impact velocity is independent of the initial condition of the impact including the impact velocity and temperature gradients. The analytical modeling of the problem also verifies the accuracy of these results. Interestingly, there is a relationship between the 3D printing process and icephobicity for that one needs to look at nature. Antarctic penguins reside in a harsh environment where air temperature may reach -40C with wind speed of 40 m/s and water temperature remains around -2.2∘C. Penguins are constantly in and out of the water and splashed by waves, yet even in sub-freezing conditions, the formation of macroscopic ice is not observed on their feathers. Bird feathers are naturally hydrophobic ; however, penguins have an additional hydrophobic coating on their feathers to reinforce their non-wetting properties. This coating consists of preen oil which is applied to the feathers from the gland near the base of the tail. The combination of the feather’s hydrophobicity and surface texture is known to increase the contact angle of water drops on penguin feathers to over 140∘ and classify them as superhydrophobic. We here develop an in-depth analysis of ice formation mechanism on superhydrophobic surfaces through careful experimentations and development of a theory to address how ice formation is delayed on these surfaces. Furthermore, we investigate the anti-icing properties of warm and cold weather penguins with and without preen oil to further design a surface minimizing the frost formation which is of practical interest especially in aircraft industry.https://cassyni-user-files-prod.s3.amazonaws.com/JTfPx6HcYrUWbtzVx4NBXL https://cassyni.com/slides/outline/7Fyeqq8ZhuMrHM2VFnw1SM https://cassyni.com/events/7Fyeqq8ZhuMrHM2VFnw1SM/abstract https://cassyni-user-files-prod.s3.amazonaws.com/6zuNN7S7vPe6pykEeiXBmY https://cassyni.com/events/7Fyeqq8ZhuMrHM2VFnw1SM?videoPreview=1 Depth-limited wave breaking dissipation in a potential flow codenohttps://cassyni.com/events/7Fyeqq8ZhuMrHM2VFnw1SM?videoPreview=12022-04-12T10:40:00+00:001258.04Water WavesSimulation of waves beyond the breaking point in a fully non-linear potential flow model (e.g. Raoult et al. [1]) is considered with a semi-empirical dissipation term that requires correctly determining the breaking onset and estimating the energy dissipation rate. A kinematic breaking criterion, similar to those found recently to be practical for arbitrary water depth (e.g. Derakthi et al. [2]), is applied here. The criterion is based on 푈/퐶, the ratio of the free surface water velocity to the wave phase speed. To estimate the wave breaking strength in shallow water, previous work by Svendsen et al. [3] that continues to be used and developed (e.g. Grilli et al. [4]), has shown that a hydraulic jump model can provide a reliable approach for spilling shallow water breakers. Alternatively, Derakthi et al. [5] proposed a parameterization for the breaking strength in deep and intermediate water depending on the rate of change of 푈/퐶. Here, a range of depth-limited wave breaking cases for regular and irregular waves are considered and validated with experimental measurements, and values for the rate of change of 푈/퐶 and the breaking strength are calculated for shallow water cases. Current work includes exploring if and how these different parameterizations may be combined to develop a unified approach to be applied in fully nonlinear potential flow models.https://cassyni-user-files-prod.s3.amazonaws.com/6zuNN7S7vPe6pykEeiXBmY https://cassyni.com/slides/outline/pr1LK1nssGmtUnFeswDSu https://cassyni.com/events/pr1LK1nssGmtUnFeswDSu/abstract https://cassyni-user-files-prod.s3.amazonaws.com/9rFMwSfjQvfLrknLVqYeDU https://cassyni.com/events/pr1LK1nssGmtUnFeswDSu?videoPreview=1 An Intuitionist Reasoning Upon Formal Intuitionist Logic: Logical Analysis of Kolmogorov's 1932 Papernohttps://cassyni.com/events/pr1LK1nssGmtUnFeswDSu?videoPreview=12022-02-09T11:40:00+00:006867.2Logica UniversalisTwo dichotomies are considered as the foundations of a scientific theory: the kind of infinity—either potential or actual-, and the kind of organization of the theory—axiomatic or problem-based. The original intuitionist program relied on the choices of potential infinity and the problem-based organization. I show that the logical theory of Kolmogorov’s 1932 paper relied on the same choices. A comparison of all other theories sharing the same foundational choices allows us to characterize their common theoretical development through a few logical steps. The theory illustrated by Kolmogorov’s paper is then rationally re-constructed according to the steps of this kind of development. One obtains a new foundation of intuitionist logic, which is of a structural kind since it is based on and developed according to the structure of the above mentioned two fundamental choices. In addition, Kolmogorov’s illustration of his theory of intuitionist logic is an instance of rigorous reasoning of the intuitionist kind.https://cassyni-user-files-prod.s3.amazonaws.com/9rFMwSfjQvfLrknLVqYeDU https://cassyni.com/slides/outline/GeJ8ipRY3bt896VdAvQaJy https://cassyni.com/events/GeJ8ipRY3bt896VdAvQaJy/abstract https://cassyni-user-files-prod.s3.amazonaws.com/LxqTUpj3Hj7B5DpadczfDx https://cassyni.com/events/GeJ8ipRY3bt896VdAvQaJy?videoPreview=1 The Talmudic Logic Projectnohttps://cassyni.com/events/GeJ8ipRY3bt896VdAvQaJy?videoPreview=12021-06-23T10:40:00+00:005592.84Logica UniversalisWe describe the state of the Talmudic Logic project as of end of 2019. The Talmud is the most comprehensive and fundamental work of Jewish religious law, employing a large number of logical components centuries ahead of their time. In many cases the basic principles are not explicitly formulated, which makes it difficult to formalize and make available to the modern student of Logic. This project on Talmudic Logic, aims to present logical analysis of Talmudic reasoning using modern logical tools. We investigate principles of Talmudic Logic and publish a series of books, one book or more for each principle. http://www.collegepublications.co.uk/stl/ The series begins with the systematic analysis of Talmudic inference rules. The first book shows that we can present Talmudic reasoning intuitions as a systematic logical system basic to modern non-deductive reasoning, such as Argumentum A Fortiori, Abduction and Analogy. The second book offers a systematic common sense method for intuitively defining sets and claims that this method adequately models the Talmudic use of the rules Klal uPrat. These books also criticize modern Talmudic research methodology. Later books deal with additional topics like Deontic logic, and Temporal logic, Agency and processes in the Talmud and more. The aims of the project are two fold: 1. To import into the Talmudic study modern logical methods with a view to help understand complicated Talmudic passages, which otherwise cannot be addressed. 2. To export from the Talmud new logical principles which are innovative and useful to modern contemporary logic.https://cassyni-user-files-prod.s3.amazonaws.com/LxqTUpj3Hj7B5DpadczfDx https://cassyni.com/events/9Ea52ZifTjacP4Jicknwru/abstract https://cassyni-user-files-prod.s3.amazonaws.com/5ypGkWqXPYGuTXUP6NjTXk https://cassyni.com/slides/outline/Q43pXheJ2q7gn9iVRNCkMb https://cassyni.com/events/Q43pXheJ2q7gn9iVRNCkMb/abstract https://cassyni-user-files-prod.s3.amazonaws.com/XufBTFk18sKcs6mCbMvpLn https://cassyni.com/events/Q43pXheJ2q7gn9iVRNCkMb?videoPreview=1 The Riemann mapping theorem from Riemann’s viewpointnohttps://cassyni.com/events/Q43pXheJ2q7gn9iVRNCkMb?videoPreview=12022-07-27T13:00:00+00:003196.48 Journal of Geometric Analysis & Complex Analysis and its SynergiesThe Riemann Mapping Theorem (RMT for short) is in every Textbook on Complex Variables. It was first announced in Riemann’s lecture in 1851, the lecture notes of which are available even on the internet. Nevertheless, what one finds in the textbooks is the proof by Carathéodory, which takes a viewpoint quite different from Riemann’s original. On the other hand, Riemann’s original viewpoint is novel and rich, but too sketchy to be accepted as precise proof, as many experts say. Then in 2017, Robert E. Greene of UCLA and I gave detailed proof of the general case following the ideas of Riemann [1]. The purpose of this presentation is to give a comprehensive report on it.https://cassyni-user-files-prod.s3.amazonaws.com/XufBTFk18sKcs6mCbMvpLn https://cassyni.com/slides/outline/JcvB2BXXCo2cPHUFpTCxN9 https://cassyni.com/events/JcvB2BXXCo2cPHUFpTCxN9/abstract https://cassyni-user-files-prod.s3.amazonaws.com/9cKDLgrLNWPuB7HgM1BhrN https://cassyni.com/events/JcvB2BXXCo2cPHUFpTCxN9?videoPreview=1 On Another Planenohttps://cassyni.com/events/JcvB2BXXCo2cPHUFpTCxN9?videoPreview=12021-02-27T15:00:00+00:00525.04Mathematical IntelligencerNo abstracthttps://cassyni-user-files-prod.s3.amazonaws.com/9cKDLgrLNWPuB7HgM1BhrN https://cassyni.com/slides/outline/S2eEiSEPnfLSsrzinL4gn9 https://cassyni.com/events/S2eEiSEPnfLSsrzinL4gn9/abstract https://cassyni-user-files-prod.s3.amazonaws.com/5VhYT42U8Fns7EMN6CBaFp https://cassyni.com/events/S2eEiSEPnfLSsrzinL4gn9?videoPreview=1 Dynamic Constraint Aggregation for Solving Very Large-scale Airline Crew Pairing Problemsnohttps://cassyni.com/events/S2eEiSEPnfLSsrzinL4gn9?videoPreview=12021-02-11T16:16:24+00:00659.04Operations Research ForumNo abstracthttps://cassyni-user-files-prod.s3.amazonaws.com/5VhYT42U8Fns7EMN6CBaFp https://cassyni.com/slides/outline/Kbo3Q76H3JErraGPg4zKUZ https://cassyni.com/events/Kbo3Q76H3JErraGPg4zKUZ/abstract https://cassyni-user-files-prod.s3.amazonaws.com/T3N7h92k2Lu7HzDmVcWiA https://cassyni.com/events/Kbo3Q76H3JErraGPg4zKUZ?videoPreview=1 Storm clouds and rainbows: intersectional discourses of parents of transgender children in Aotearoanohttps://cassyni.com/events/Kbo3Q76H3JErraGPg4zKUZ?videoPreview=12022-10-21T03:00:00+00:002974.44Linguistics and Applied Language StudiesThis talk presents the results of a research project exploring the intersectional discourses adopted by parents of transgender children in Aotearoa to support their children and resist gender-based oppression. There is a growing body of research on parent experiences in this area, but it has overwhelming focused on trauma rather than resilience, and on parents who are white North American middle-class mothers. Existing research has pointed to a range of social discourses about childhood gender diversity that parents encounter, but our project is the first to analyse how parents respond to these from a discourse analysis perspective. Our research uses the method of reflective drawing, asking 20 parents of different genders, sexual orientations, and cultural backgrounds to draw their experience of parenting a transgender child and to discuss this in interview. We identify seven visual metaphors in the parents’ drawings, each representing distinct discourses of gender affirmation: these include storm clouds and rainbows, a maze, family portraits, blank space, holding hands, hearts, and arches. Using critical multimodal discourse analysis, we explore how the participants discursively construct their experience from their uniquely situated perspectives, as Māori, Pasifika, Asian, Pākehā, female, male, non-binary and queer parents. We argue that these perspectives reveal both challenges and benefits, reflecting the burdens of intersectional oppression, while fostering the parents’ capacity for engaging in discursive resistance to advance their children’s interests. https://cassyni-user-files-prod.s3.amazonaws.com/T3N7h92k2Lu7HzDmVcWiA https://cassyni.com/events/qGM3kk5vHAg5eEGwQ1qvD/seminar/qa https://cassyni.com/slides/outline/qGM3kk5vHAg5eEGwQ1qvD https://cassyni.com/events/qGM3kk5vHAg5eEGwQ1qvD/abstract https://cassyni-user-files-prod.s3.amazonaws.com/NZyNmsTqWzH6vAuYnfX1HG https://cassyni.com/events/qGM3kk5vHAg5eEGwQ1qvD?videoPreview=1 A consensus on the definition of positive animal welfarenohttps://cassyni.com/events/qGM3kk5vHAg5eEGwQ1qvD?videoPreview=12025-01-23T12:15:00+00:00923.04Royal Society PublishingThe concept of animal welfare is evolving due to progress in our scientific understanding of animal biology and changing societal expectations. Animal welfare science has been primarily concerned with minimising suffering, but there is growing interest in also promoting positive experiences, grouped under the term Positive Animal Welfare (PAW). However, there are discrepancies in the use of the term PAW. An interdisciplinary group arrived at a consensus that “PAW can be defined as the animal flourishing through the experience of predominantly positive mental states and the development of competence and resilience. Positive animal welfare goes beyond ensuring good physical health and the prevention and alleviation of suffering. It encompasses animals experiencing positive mental states resulting from rewarding experiences, including having choices and opportunities to actively pursue goals and achieve desired outcomes”. The definition also considers individual and species-specific differences. It provides a framework for researchers to investigate PAW and thereby generate innovative, informative, and reproducible science. Studies of PAW can contribute to a richer picture of an animal’s life and may elucidate the biological foundations of happiness. The definition creates opportunities to inspire scientific progress in animal biology, and to align animal care practices, legislation and markets with societal expectations.https://cassyni-user-files-prod.s3.amazonaws.com/NZyNmsTqWzH6vAuYnfX1HG https://cassyni.com/slides/outline/7GPzZGrrkKFkUWUWYK1duf https://cassyni.com/events/7GPzZGrrkKFkUWUWYK1duf/abstract https://cassyni-user-files-prod.s3.amazonaws.com/8Y2YWJUuqSK7pxJ3HNZxxW https://cassyni.com/events/7GPzZGrrkKFkUWUWYK1duf?videoPreview=1 RNA Splicing: A split consensus reveals two major 5' splice site classesnohttps://cassyni.com/events/7GPzZGrrkKFkUWUWYK1duf?videoPreview=12025-06-05T09:00:00+00:002874.04Royal Society PublishingThe established consensus sequence for human 5’ splice sites masks the presence of two major splice site classes defined by preferential base-pairing potentials with either U5 snRNA loop 1 or the U6 snRNA ACAGA box. The two 5’ splice site classes are separable in genome sequences, sensitised by specific genotypes, and associated with splicing complexity. The two classes reflect the commitment to 5’ splice site usage occurring primarily during 5’ splice site transfer to U6 snRNA. Separating the human 5’ splice site consensus into its two major constituents can help us understand fundamental features of eukaryote genome architecture and splicing mechanisms and inform treatment design for diseases caused by genetic variation affecting splicing.https://cassyni-user-files-prod.s3.amazonaws.com/8Y2YWJUuqSK7pxJ3HNZxxW https://cassyni.com/slides/outline/EBUTCqvCtj1XyKU5ukaa4M https://cassyni.com/events/EBUTCqvCtj1XyKU5ukaa4M/abstract https://cassyni-user-files-prod.s3.amazonaws.com/MKjgNxT8rMWLe7YN9khtyL https://cassyni.com/events/EBUTCqvCtj1XyKU5ukaa4M?videoPreview=1 Genetic variation in age-dependent attractiveness in a fish with a mixed mating systemnohttps://cassyni.com/events/EBUTCqvCtj1XyKU5ukaa4M?videoPreview=12025-02-08T17:00:00+00:00973.24Royal Society PublishingReproductive senescence is common across taxa and females often show a predictable decline in fecundity after maturity. Attending to these age-dependent cues could help males make optimal mate choice decisions. Here, we examined reproductive senescence and male mate choice in the androdioecious mangrove rivulus (*Kryptolebias marmoratus*) where self-fertilizing hermaphrodites exist with rare males. Hermaphrodites showed a strong decline in fecundity as they aged and genetic lineages varied in their fecundity both at young and old ages. Surprisingly, when given a simultaneous choice between genetically identical old and young hermaphrodites males did not simply prefer younger hermaphrodites. Instead, male preference for younger vs older partners depended on the genetic lineage of the partners, resulting in a strong genotype x age interaction. For some genetic lineages, hermaphrodites were more attractive to males when younger, but for other genetic lineages, hermaphrodites were more attractive when older. Our results suggest that genetic identity of the partner is key to how males weigh age-dependent changes in fecundity, and that males are able to assess genetic variation in attractiveness over a partner’s reproductive lifespan. Exploring how gamete viability and outcrossing is affected by age across genetic lineages could help us further understand these male preferences.https://cassyni-user-files-prod.s3.amazonaws.com/MKjgNxT8rMWLe7YN9khtyL https://cassyni.com/slides/outline/T2PQdsmd7MGDtFy9TPZ5gy https://cassyni.com/events/T2PQdsmd7MGDtFy9TPZ5gy/abstract https://cassyni-user-files-prod.s3.amazonaws.com/DVbprS16QmWTkhdvxVKdV8 https://cassyni.com/events/T2PQdsmd7MGDtFy9TPZ5gy?videoPreview=1 Science and field work in the McMurdo Dry Valleys, Antarcticanohttps://cassyni.com/events/T2PQdsmd7MGDtFy9TPZ5gy?videoPreview=12025-03-18T10:00:00+00:00923.16Microbiome Virtual International ForumAntarctica was once thought to be a lifeless continent, defined by its most notably feature, a continuous sheet of ice. However, diverse microbial lifeforms thrive in this otherwise inhospitable habitat, particularly in the rare places where sufficient light and liquid water are available. The McMurdo Dry Valleys (MDVs) harbor one of the most diverse and productive microbial habitats in Antarctica. Nestled within the valleys of the Transantarctic Mountains in Eastern Antarctica, the MDVs are a cold desert region, characterized by dry soils and minimum annual precipitation. Permanently ice-covered lakes represent oases receiving limited light and year-round liquid water for consortia of microorganisms. Within the stratified water columns, diverse communities of protists play important roles in carbon and nutrient cycling within truncated food webs dominated by the microbial loop. Our research group has studied the distribution and function of the MDV lake protist community for nearly two decades. In this seminar long-term studies of Antarctic protists in the field and lab will be discussedhttps://cassyni-user-files-prod.s3.amazonaws.com/DVbprS16QmWTkhdvxVKdV8 https://cassyni.com/events/5HqCVAnePqy5w2zTnjDyMw/seminar/qa https://cassyni.com/slides/outline/5HqCVAnePqy5w2zTnjDyMw https://cassyni.com/events/5HqCVAnePqy5w2zTnjDyMw/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Qs58GARTPioC2y8dMtS3hp https://cassyni.com/events/5HqCVAnePqy5w2zTnjDyMw?videoPreview=1 Cantor set structure of the weak stability boundary for infinitely many cycles in the restricted three-body problem, Aegis, the ESA asteroid orbit determination and impact monitoring systemnohttps://cassyni.com/events/5HqCVAnePqy5w2zTnjDyMw?videoPreview=12025-03-28T14:00:00+00:004840.04Celestial Mechanics and Dynamical AstronomyThe geometry of the weak stability boundary region for the planar restricted three-body problem about the secondary mass point has been an open problem. Previous studies have conjectured that it may have a fractal structure. This region is studied for infinitely many cycles about the secondary mass point, instead of a finite number studied previously. It is shown that the boundary consists of a family of infinitely many Cantor sets and is thus fractal in nature. It is also shown that on two-dimensional surfaces of section, it is the boundary of a region only having bounded cycling motion for infinitely many cycles, while the complement of this region generally has unbounded motion. It shares properties of a Mandelbrot set. Its relationship to the non-existence of KAM tori is described, among many other properties. An interesting application is discussed on capture into the Solar System. The NEO Coordination Centre (NEOCC) of the European Space Agency is an operational centre that, among other activities, computes the orbits of near-Earth objects and their probabilities of impact with the Earth. The NEOCC started providing information about near-Earth objects in 2012 on a dedicated web portal, accessible at https://neo.ssa.esa.int/. Since the beginning of the operational phase, many developments and improvements have been implemented regarding the software, the data provided, and the portal. One of the most important upgrades is that the NEOCC is now independently providing data through a newly developed Orbit Determination and Impact Monitoring system, named Aegis. All the data computed by Aegis are publicly available on the NEOCC web portal, and Aegis is also used to maintain all the major services offered. The most important services comprise an orbital catalogue of all known asteroids, a list of possible future impacts with the Earth (also called Risk List), a list of forthcoming close approaches, a set of graphical toolkits, and an on-demand ephemerides service. Many of the services are also available through dedicated APIs, which can be used to automatically retrieve data. Here we give an overview of the algorithms implemented in the Aegis software, give a practical example of usage for planetary defence, and provide a summary of the services offered by the NEOCC that are supported by Aegis. https://cassyni-user-files-prod.s3.amazonaws.com/Qs58GARTPioC2y8dMtS3hp https://cassyni.com/slides/outline/2KyCKhRPATaGiogQwAxz1K https://cassyni.com/events/2KyCKhRPATaGiogQwAxz1K/abstract https://cassyni-user-files-prod.s3.amazonaws.com/QwckttPYB4MicpHKKupLaa https://cassyni.com/events/2KyCKhRPATaGiogQwAxz1K?videoPreview=1 Do anomalies break the momentum routing invariance?nohttps://cassyni.com/events/2KyCKhRPATaGiogQwAxz1K?videoPreview=12025-04-26T16:00:00+00:002810.32Annals of PhysicsIn this talk it is intended to show that anomalies do not break the momentum routing invariance of Feynman diagrams. Well known textbook exemples are revisted and the main idea is applied to a framework with non-minimal Lorentz violation. https://cassyni-user-files-prod.s3.amazonaws.com/QwckttPYB4MicpHKKupLaa https://cassyni.com/events/pxVnq5LVJygU5z1qK5ekD/seminar/qa https://cassyni.com/slides/outline/pxVnq5LVJygU5z1qK5ekD https://cassyni.com/events/pxVnq5LVJygU5z1qK5ekD/abstract https://cassyni-user-files-prod.s3.amazonaws.com/YBpT8CDdyUei7zE5j3ayy8 https://cassyni.com/events/pxVnq5LVJygU5z1qK5ekD?videoPreview=1 Home Haemodialysis: Problem-based learning 0930-1100 nohttps://cassyni.com/events/pxVnq5LVJygU5z1qK5ekD?videoPreview=12025-09-18T08:30:00+00:006547.8Imperial College Renal and Transplant Centre0930 Vascular Access in Home Haemodialysis, Paul Herbert Transplant and VA Surgeon and Saidat Abbas VA Nurse Specialist, ICHNT 1015 Home Haemodialysis, Technologies and the potential for AI, Alirio Martinho Belchior Lead Nurse, Portsmouth University Hospital Image credit: [Marek Piwnicki (Unsplash)](https://unsplash.com/photos/a-red-and-white-photo-of-trees-with-no-leaves-JE4AbhuFJII).https://cassyni-user-files-prod.s3.amazonaws.com/YBpT8CDdyUei7zE5j3ayy8 https://cassyni.com/slides/outline/3HnQMhQThFaubXLYEWCuJm https://cassyni.com/events/3HnQMhQThFaubXLYEWCuJm/abstract https://cassyni-user-files-prod.s3.amazonaws.com/LHk5eqmzdpP2VdtXws5c1t https://cassyni.com/events/3HnQMhQThFaubXLYEWCuJm?videoPreview=1 agenT-797: Allogeneic iNKT Cell Therapy for the Treatment of Cancer - Complete Clinical Response in a R/R Germ Cell Tumornohttps://cassyni.com/events/3HnQMhQThFaubXLYEWCuJm?videoPreview=12025-08-22T13:00:00+00:001304.96OncogeneInvariant natural killer T (iNKT) cells represent a promising new frontier in cell therapy, uniquely positioned at the crossroads of innate and adaptive immunity. With their potent, broad-spectrum anti-tumor activity and low risk of graft-versus-host disease, iNKT cells are especially well-suited for use in allogeneic cancer immunotherapy. In this presentation, we delve into the distinct biology that underpins their therapeutic potential and highlight our clinical data supporting their efficacy and safety. Notably, we report a remarkable case of complete remission in a patient with heavily pre-treated metastatic germ cell cancer, achieved with agenT-797, an ex vivo expanded, allogeneic iNKT cell therapy.https://cassyni-user-files-prod.s3.amazonaws.com/LHk5eqmzdpP2VdtXws5c1t https://cassyni.com/events/UyZ4zW5XKnEZ5RxNDsXzrH/abstract https://cassyni-user-files-prod.s3.amazonaws.com/eQYwzJugRg5qveNrF2mgr https://cassyni.com/events/9Dcu9ACXmU5uNPxKCk1GaR/seminar/qa https://cassyni.com/slides/outline/9Dcu9ACXmU5uNPxKCk1GaR https://cassyni.com/events/9Dcu9ACXmU5uNPxKCk1GaR/abstract https://cassyni-user-files-prod.s3.amazonaws.com/DzoqF8Bujed5vTQP5ALC1C https://cassyni.com/events/9Dcu9ACXmU5uNPxKCk1GaR?videoPreview=1 Decent Work for All? Confronting Precarity and Poverty in the Sustainable Development Agendanohttps://cassyni.com/events/9Dcu9ACXmU5uNPxKCk1GaR?videoPreview=12025-12-03T15:00:00+00:003731.0Springer Nature Sustainable Development Goals ProgrammeJoin us for a thought-provoking discussion on tackling precarious work in the context of digitalization, sustainability, and social equity. This seminar will delve into two pressing challenges—and explore potential solutions—for improving job quality and reducing in-work poverty during a time of rapid economic and technological transformation. Engage with leading scholars in a multidisciplinary dialogue on how to ensure decent, fair, and secure work as we navigate the twin transitions shaping the future of employment.https://cassyni-user-files-prod.s3.amazonaws.com/DzoqF8Bujed5vTQP5ALC1C https://cassyni.com/slides/outline/4HAUnxFAnFUL4TN2zDtLoF https://cassyni.com/events/4HAUnxFAnFUL4TN2zDtLoF/abstract https://cassyni-user-files-prod.s3.amazonaws.com/KuC3y1imCgsfWLtugbzESz https://cassyni.com/events/4HAUnxFAnFUL4TN2zDtLoF?videoPreview=1 The effect of type 2 diabetes genetic predisposition on non-cardiovascular comorbiditiesnohttps://cassyni.com/events/4HAUnxFAnFUL4TN2zDtLoF?videoPreview=12025-11-20T16:44:33+00:001186.8Research Seminars by Springer NatureType 2 diabetes is associated with a range of non-cardiovascular non-oncologic comorbidities. To move beyond associations and evaluate causal effects between type 2 diabetes genetic predisposition and 21 comorbidities, we apply Mendelian randomization analysis using genome-wide association studies across multiple genetic ancestries. Additionally, leveraging eight mechanistic clusters of type 2 diabetes genetic profiles, each representing distinct biological pathways, we investigate causal links between cluster-stratified type 2 diabetes genetic predisposition and comorbidity risk. We identify causal effects of type 2 diabetes genetic predisposition driven by distinct genetic clusters. For example, the risk-increasing effects of type 2 diabetes genetic predisposition on cataracts and erectile dysfunction are primarily attributed to adiposity and glucose regulation mechanisms, respectively. We observe opposing effect directions across different genetic ancestries for depression, asthma and chronic obstructive pulmonary disease. Our findings leverage the heterogeneity underpinning type 2 diabetes genetic predisposition to prioritize biological mechanisms underlying causal relationships with comorbidities.https://cassyni-user-files-prod.s3.amazonaws.com/KuC3y1imCgsfWLtugbzESz https://cassyni.com/slides/outline/9iJ8JUMwcHZjBrwpzr8Ekd https://cassyni.com/events/9iJ8JUMwcHZjBrwpzr8Ekd/abstract https://cassyni-user-files-prod.s3.amazonaws.com/AsBvMGQ1eDBJ8hH97STmTk https://cassyni.com/events/9iJ8JUMwcHZjBrwpzr8Ekd?videoPreview=1 Heatwaves impair female but not male fertility in a subsocial insectnohttps://cassyni.com/events/9iJ8JUMwcHZjBrwpzr8Ekd?videoPreview=12025-12-11T22:00:00+00:00970.76Royal Society PublishingClimate change is increasing the frequency of heatwaves with detrimental effects on reproduction. Sex differences in thermal sensitivity of fertility could impact population persistence under global warming, with some predictions indicating increased vulnerability in males. Yet, few studies have measured both male and female fertility simultaneously. Here, we investigated the independent and combined effect of temperature stress on male and female reproductive success and offspring fitness in the burying beetle Nicrophorus vespilloides. Despite the expectation of increased thermal sensitivity in males, we found a significant reduction in all reproductive success traits when females, but not males, were exposed to a heatwave. We also found evidence for additive combined effects of heat stress on male and female fertility, although this had no downstream consequences for offspring fitness. In sum, our findings suggest that the effects of climate change on female fertility may have been underestimated. This could have important implications for populations under increasing environmental threat given that population growth tends to be determined by female fertility.https://cassyni-user-files-prod.s3.amazonaws.com/AsBvMGQ1eDBJ8hH97STmTk https://cassyni.com/slides/outline/FAVS9v4Pk2rRAzkECD49Ks https://cassyni.com/events/FAVS9v4Pk2rRAzkECD49Ks/abstract https://cassyni-user-files-prod.s3.amazonaws.com/LBvg8NrKqq8kDph16fvef8 https://cassyni.com/events/FAVS9v4Pk2rRAzkECD49Ks?videoPreview=1 Isolation, engineering and ecology of temperate phages from the human gutnohttps://cassyni.com/events/FAVS9v4Pk2rRAzkECD49Ks?videoPreview=12026-02-10T02:00:00+00:00651.88Microbiome Virtual International ForumLarge-scale metagenomic and data-mining efforts have revealed an expansive diversity of bacteriophages (phages) within the human gut1,2,3. However, functional understanding of phage–host interactions within this complex environment is limited, largely due to a lack of cultured isolates available for experimental validation. Here we characterize 134 inducible prophages originating from 252 human gut bacterial isolates using 10 different induction conditions to expand the experimentally validated temperate phage–host pairs originating from the human gut. Importantly, only 18% of computationally predicted prophages could be induced in pure cultures. Moreover, we construct a 78-member synthetic microbiome that, when co-cultured in the presence of human colonic cells (Caco2), led to the induction of 35% phage species. Using cultured isolates, we demonstrate that human host-associated cellular products may act as induction agents, providing a possible link between gastrointestinal cell lysis and temperate phage populations4,5. We provide key insights into prophage diversity and genetics, including a genetic pathway for domestication, finding that polylysogeny was common and resulted in coordinated prophage induction, and that differential induction can be influenced by divergent prophage integration sites. More broadly, our study highlights the importance of culture-based techniques, alongside experimental validation, genomics and computational prediction, to understand the biology and function of temperate phages in the human gut microbiome. These culture-based approaches will enable applications across synthetic biology, biotechnology and microbiome fields.https://cassyni-user-files-prod.s3.amazonaws.com/LBvg8NrKqq8kDph16fvef8 https://cassyni.com/slides/outline/AhEEuexUFWdXJYfDFoZwgq https://cassyni.com/events/AhEEuexUFWdXJYfDFoZwgq/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Q8VZH5rrebMGkNS8eNt342 https://cassyni.com/events/AhEEuexUFWdXJYfDFoZwgq?videoPreview=1 Blooming Ambitions: Nineteenth-Century Flower Exhibitions, Science, and the Cultivation of Urban Life in Portugalnohttps://cassyni.com/events/AhEEuexUFWdXJYfDFoZwgq?videoPreview=12026-03-09T13:00:00+00:001848.36Royal Society PublishingThis talk explores nineteenth-century Portuguese horticultural exhibitions, situating them within European exhibition culture. It shows how these events helped professionalize horticulture and provided a platform for gardeners, horticulturists, and amateurs—including women—to showcase innovations and contribute to scientific knowledge. Focusing on the evolving leadership of Lisbon and Porto, the study highlights how exhibitions promoted competition, knowledge exchange, and public engagement, transforming plants into objects of science, art, and culture. By examining the role of the Royal Society of Horticulture, the talk demonstrates how these exhibitions fostered both urban modernization and broader cultural appreciation of horticulture in Portugal.https://cassyni-user-files-prod.s3.amazonaws.com/Q8VZH5rrebMGkNS8eNt342 https://cassyni.com/slides/outline/XSVExzeQ66p3ppBffUWSQD https://cassyni.com/events/XSVExzeQ66p3ppBffUWSQD/abstract https://cassyni-user-files-prod.s3.amazonaws.com/3danTiAeQQ1i3mu7AeJrCe https://cassyni.com/events/XSVExzeQ66p3ppBffUWSQD?videoPreview=1 Faster speciating cacti have faster evolving flowersnohttps://cassyni.com/events/XSVExzeQ66p3ppBffUWSQD?videoPreview=12026-02-25T11:30:25+00:001817.64Royal Society PublishingThe rise of biodiversity is shaped by variation in speciation rates. Across many taxonomic groups, both trait values and the rates at which traits evolve have been proposed to influence diversification, but these factors can act independently. Here, we test two competing hypotheses in the cactus family, that speciation depends on flower length variation, or on the rate of evolutionary change in flower length. Across >750 species in 107 genera, we find that flower length is only weakly related to speciation, whereas the rate of flower-length evolution is a strongly positive predictor. Moreover, flower length and rate of evolutionary change in flower length are only weakly correlated, indicating that rapid change, rather than any particular floral morphology, underlies cactus diversification. These results challenge expectations that specialised morphologies accelerate diversification, suggesting instead that in cacti it is the tempo of floral change, rather than any particular floral form, that explains their extraordinary diversity.https://cassyni-user-files-prod.s3.amazonaws.com/3danTiAeQQ1i3mu7AeJrCe https://cassyni.com/slides/outline/5G9qdPsUECPV7ewmz7RUS9 https://cassyni.com/events/5G9qdPsUECPV7ewmz7RUS9/abstract https://cassyni-user-files-prod.s3.amazonaws.com/MSEf3V6hGw4ye4Gvv5fh58 https://cassyni.com/events/5G9qdPsUECPV7ewmz7RUS9?videoPreview=1 Microstructural biomechanics underpin Cambrian phosphatic brachiopod diversification nohttps://cassyni.com/events/5G9qdPsUECPV7ewmz7RUS9?videoPreview=12026-04-17T10:00:00+00:00864.32Royal Society PublishingThis study investigates the microstructure and biomechanics of the Wuliuan phosphatic brachiopods Iberotreta sampelayoi and Genetreta trilix from the Láncara Formation in northern Spain. Both taxa share the characteristic stacked columnar shell architecture of early linguliforms, yet quantitative analyses reveal marked differences in microcolumn geometry. Iberotreta possesses small, densely packed and highly regulated columns, whereas Genetreta develops larger, more heterogeneous columns with weaker geometric constraint. Statistical comparisons show that all column dimensions differ significantly between species, and allometric analyses indicate tightly coordinated growth in Iberotreta versus a less constrained pattern in Genetreta, consistent with greater sensitivity to local physiological or environmental conditions. Biomechanical modelling demonstrates that these disparities correspond to contrasting functional strategies: G. trilix withstands higher stresses, particularly in the lateral middle region, while I. sampelayoi maintains stiffness with reduced mineral investment, producing a lightweight and energetically efficient shell. Comparisons with extant brachiopods support a functional link between shell microstructure and biomechanical performance. Together, our results demonstrate that variation in column size, organization and allometry served as an adaptive axis in early phosphatic brachiopods, showing that micrometre-scale skeletal architecture played a central role in shaping the ecological complexity of Cambrian benthic communities during the early Cambrian.https://cassyni-user-files-prod.s3.amazonaws.com/MSEf3V6hGw4ye4Gvv5fh58 https://cassyni.com/slides/outline/R29FhznEbEPxXi2Fs2aFSd https://cassyni.com/events/R29FhznEbEPxXi2Fs2aFSd/abstract https://cassyni-user-files-prod.s3.amazonaws.com/SXnRof5UsTkHz8mAgxpz6J https://cassyni.com/events/R29FhznEbEPxXi2Fs2aFSd?videoPreview=1 The seminal proteome of a monandrous fly, Drosophila subobscuranohttps://cassyni.com/events/R29FhznEbEPxXi2Fs2aFSd?videoPreview=12026-06-08T07:00:00+00:00826.84Royal Society PublishingWhen females mate with multiple partners, males can improve their fertility by transferring proteins that influence female behaviour. In species where females rarely re-mate, competition between males is reduced and ejaculates are expected to contain fewer manipulative proteins. We characterised seminal fluid proteins in the fruit fly, Drosophila subobscura, a species where females usually mate just once, and compared them to a related species, D. melanogaster, where females mate multiple times. We found that D. subobscura males still produce manipulative proteins, similar to D. melanogaster, suggesting that despite different mating systems, conflict may characterise seminal fluid protein composition of this monandrous species.https://cassyni-user-files-prod.s3.amazonaws.com/SXnRof5UsTkHz8mAgxpz6J https://cassyni.com/slides/outline/TVPGwR1rnXASteVpQiUtAZ https://cassyni.com/events/TVPGwR1rnXASteVpQiUtAZ/abstract https://cassyni-user-files-prod.s3.amazonaws.com/T4bK8vbsZpuQVD1bUcMyJv https://cassyni.com/events/TVPGwR1rnXASteVpQiUtAZ?videoPreview=1 Energetic flexibility as a hidden axis of life-history trade-offs: experimental evidence from a long-lived seabirdnohttps://cassyni.com/events/TVPGwR1rnXASteVpQiUtAZ?videoPreview=12026-06-15T09:22:47+00:001717.56Royal Society PublishingBalancing current reproductive investment with survival and future fecundity is a central challenge for long-lived animals, shaping life-history evolution. Although carry-over effects are well documented, the underlying energetic mechanisms remain unclear. Herein, we introduce the energetic flexibility concept, i.e. the ability of individuals to dynamically reallocate energy among competing life-history functions, which serves as a hidden axis influencing carry-over effects. We manipulated energetic costs in breeding black-legged kittiwakes (Rissa tridactyla) through food-supplementation and wing-clipping and tracked post-breeding migration. Individuals incurring higher energetic costs exhibited lower immediate breeding success, departed the colony earlier, travelled longer distances and achieved higher subsequent reproductive success, albeit with reduced apparent survival. Reduced energetic costs did not exhibit detectable carry-over effects on migration or reproduction. Oxidative stress, a proxy for physiological condition, did not increase in individuals with elevated energetic costs, implying prioritized self-maintenance. Collectively, these results showed that individuals flexibly reallocated energy to compensate for short-term costs and invested in future fitness. Our findings provide rare experimental evidence that energetic trade-offs mediate behavioural and reproductive carry-over effects. Recognizing energetic flexibility as a hidden axis of carry-over effects offers a unifying framework for understanding the mechanisms whereby animals balance reproduction, survival and migration in variable environments.https://cassyni-user-files-prod.s3.amazonaws.com/T4bK8vbsZpuQVD1bUcMyJv https://cassyni.com/slides/outline/2ny4dEfcqdUVjCD5tVtnUu https://cassyni.com/events/2ny4dEfcqdUVjCD5tVtnUu/abstract https://cassyni-user-files-prod.s3.amazonaws.com/A34bXeURLZdpj1LNJpwfxJ https://cassyni.com/events/2ny4dEfcqdUVjCD5tVtnUu?videoPreview=1 Spine Open Journal Club: July 2026nohttps://cassyni.com/events/2ny4dEfcqdUVjCD5tVtnUu?videoPreview=12026-07-28T01:00:00+00:003475.4In this journal club, we will discuss three of the most popular articles in the initial series of publications at Spine Open. The live discussion will take place on July 27, 2026 at 9PM Eastern. This Spine Open Journal Club will present three highlight articles from the first series of publications in Spine Open. This 60 minute journal club will discuss the following papers: 1. A Retrospective Analysis of Early Outcomes from a Biphasic Calcium Phosphate Bone Graft With a Submicron, Needle-Like Surface Topography Used in Posterior Spinal Fusion Procedures. 2. Evaluating Two Recombinant BMP-2 Formulations in Transforaminal Lumbar Fusion: Does the Carrier Matter? 3. Volume-Outcome Relationship in Oncologic Surgery for Metastatic Spine Disease: A Systematic Review Editor in Chief Andrew Schoenfeld will discuss the articles with guest hosts Dr. Todd Albert and Dr. Addisu Mesfin.https://cassyni-user-files-prod.s3.amazonaws.com/A34bXeURLZdpj1LNJpwfxJ https://cassyni.com/slides/outline/ACh8KVNVRVnLDmjYrNkWtu https://cassyni.com/events/ACh8KVNVRVnLDmjYrNkWtu/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Jp8USnkH1s1d97AioEpmHg https://cassyni.com/events/ACh8KVNVRVnLDmjYrNkWtu?videoPreview=1 Sphingosine-1-phosphate receptor modulators resensitizeFLT3-ITD acute myeloid leukemia cells with NRAS mutations toFLT3 inhibitorsnohttps://cassyni.com/events/ACh8KVNVRVnLDmjYrNkWtu?videoPreview=12026-06-30T15:00:00+00:001558.28LeukemiaFLT3 inhibitor efficacy in AML with FLT3-ITD is short-lived, frequently due to new mutations, most commonly in NRAS. Sphingosine kinase1 (SPHK1), which phosphorylates sphingosine to generate sphingosine-1-phosphate (S1P), is upregulated and localized to the plasmamembrane in RAS-mutated cells. We studied S1P and FLT3 co-targeting to overcome FLT3 inhibitor resistance in NRAS-mutated FLT3-ITDAML cells. NRAS-mutated FLT3-ITD AML cell lines and patient blasts were treated with FLT3 inhibitors and/or S1P receptor (S1PR)modulators. FLT3 inhibitor sensitivity was assessed by immunoblotting, cytotoxicity, apoptosis and colony formation. Co-treatment wasalso assessed in vivo in an orthotopic mouse model. Downstream RAS and SPHK1 effectors were measured by immunoblotting and qRT-PCR. The S1PR modulators fingolimod (FTY720) and mocravimod (KRP-203) resensitized FLT3-ITD-expressing MOLM-14 and MV4-11human AML cells with G12D, G12S, Q61K or Q61H, but not G12C, and patient blasts with G13D, G13V or G12D NRAS mutations to FLT3inhibitors. Moreover, FTY720 co-treatment resensitized G12D NRAS-mutated M14(R)701 cells to gilteritinib in vivo. Co-treatment inactivatedERK, transcriptionally downregulated SPHK1, and inactivated downstream AKT, p70 S6K and BAD, with inactivation abrogated byconstitutive SPHK1 expression. The clinically applicable S1PR modulators fingolimod and mocravimod resensitize NRAS-mutated FLT3-ITDAML cells to FLT3 inhibitors, supporting potential clinical efficacy.https://cassyni-user-files-prod.s3.amazonaws.com/Jp8USnkH1s1d97AioEpmHg https://cassyni.com/slides/outline/Efqq7EQsJaJNBEDLbmmM4Z https://cassyni.com/events/Efqq7EQsJaJNBEDLbmmM4Z/abstract https://cassyni-user-files-prod.s3.amazonaws.com/XTBpCtonWuEobMjGdoYzox https://cassyni.com/events/Efqq7EQsJaJNBEDLbmmM4Z?videoPreview=1 Age-related microbiome metabolites alter RNA splicing and chromatin accessibility in the brainnohttps://cassyni.com/events/Efqq7EQsJaJNBEDLbmmM4Z?videoPreview=12025-12-10T02:00:00+00:00576.96Microbiome Virtual International ForumThe gut microbiome generates diverse metabolites that can enter the bloodstream and alter host biology, including brain function. Hundreds of physiologically relevant, gut-brain signaling molecules likely exist; however, there has been no systematic, high-throughput effort to identify and validate them. Here, we integrate computational, in vitro, and in vivo approaches to pinpoint microbiome-derived metabolites whose blood levels change during aging, and that induce corresponding changes in the mouse brain. First, we mine large-scale metabolomics datasets from human cohorts (each n ≥ 1200) to identify 30 microbiome-associated metabolites whose blood levels change with age. We then screen this panel in an in vitro transcriptomic assay to identify metabolites that perturb genes linked to age-related neurodegeneration. We then test four metabolites in an acute-exposure mouse model, and use multi-omic approaches to evaluate their impact on cellular functions in the brain. We confirm the known neurodegeneration-promoting effects of trimethylamine N-oxide (TMAO), including mitochondrial dysfunction, and further discover its disruptive impact on the pathways of glycolysis, GABAergic signaling, and RNA splicing. Additionally, we identify glycodeoxycholic acid (GDCA), a microbiome-derived secondary bile acid, as a potent regulator of chromatin accessibility and suppressor of genes that protect the brain from age-related, neurodegeneration-promoting insults. GDCA also acutely reduces mobility. In summary, we present a scalable framework for linking microbiome metabolites to host pathologies, and apply it to identify microbial metabolites that induce molecular changes related to neurodegeneration.https://cassyni-user-files-prod.s3.amazonaws.com/XTBpCtonWuEobMjGdoYzox