https://cassyni.com/slides/outline/wp3o5KUAhviHPEDnHfFfT https://cassyni.com/events/wp3o5KUAhviHPEDnHfFfT/abstract https://cassyni-user-files-prod.s3.amazonaws.com/X2EPszTSbbTsL1yyLwxTKC https://cassyni.com/events/wp3o5KUAhviHPEDnHfFfT?videoPreview=1 Modelling and Controlling Turbulent Flows through Deep Learningnohttps://cassyni.com/events/wp3o5KUAhviHPEDnHfFfT?videoPreview=12022-11-22T15:00:00+00:002975.64Data-Centric Engineering JournalThe advent of new powerful deep neural networks (DNNs) has fostered their application in a wide range of research areas, including more recently in fluid mechanics. In this presentation, we will cover some of the fundamentals of deep learning applied to computational fluid dynamics (CFD). Furthermore, we explore the capabilities of DNNs to perform various predictions in turbulent flows: we will use convolutional neural networks (CNNs) for non-intrusive sensing, i.e. to predict the flow in a turbulent open channel based on quantities measured at the wall. We show that it is possible to obtain very good flow predictions, outperforming traditional linear models, and we showcase the potential of transfer learning between friction Reynolds numbers of 180 and 550. We also discuss other modelling methods based on autoencoders (AEs) and generative adversarial networks (GANs), and we present results of deep-reinforcement-learning-based flow control. https://cassyni-user-files-prod.s3.amazonaws.com/X2EPszTSbbTsL1yyLwxTKC https://cassyni.com/events/LiJtyuKyqJLaayLRJmR7k9/seminar/qa https://cassyni.com/slides/outline/LiJtyuKyqJLaayLRJmR7k9 https://cassyni.com/events/LiJtyuKyqJLaayLRJmR7k9/abstract https://cassyni-user-files-prod.s3.amazonaws.com/SdZQABEKZQbz38vPw71V7t https://cassyni.com/events/LiJtyuKyqJLaayLRJmR7k9?videoPreview=1 Machine Learning for Scientific Discoverynohttps://cassyni.com/events/LiJtyuKyqJLaayLRJmR7k9?videoPreview=12023-03-23T15:30:00+00:003589.72AIAA JournalAccurate and efficient nonlinear dynamical systems models are essential to understand, predict, estimate, and control complex natural and engineered systems. In this talk, I will explore how machine learning may be used to develop these models purely from measurement data. We explore the sparse identification of nonlinear dynamics (SINDy) algorithm, which identifies a minimal dynamical system model that balances model complexity with accuracy, avoiding overfitting. This approach tends to promote models that are interpretable and generalizable, capturing the essential “physics” of the system. We also discuss the importance of learning effective coordinate systems in which the dynamics may be expected to be sparse. This sparse modeling approach will be demonstrated on a range of challenging modeling problems, for example in fluid dynamics. Because fluid dynamics is central to aerospace systems, we will emphasize the importance of machine learning solutions that are interpretable, explainable, generalizable, and that respect known physics.https://cassyni-user-files-prod.s3.amazonaws.com/SdZQABEKZQbz38vPw71V7t https://cassyni.com/slides/outline/XaaBzwZXVNX47FASvJeogy https://cassyni.com/events/XaaBzwZXVNX47FASvJeogy/abstract https://cassyni-user-files-prod.s3.amazonaws.com/FXveoEsfU9XdfNUYtriCVc https://cassyni.com/events/XaaBzwZXVNX47FASvJeogy?videoPreview=1 How to publish in the Journal of Management Studies (JMS)nohttps://cassyni.com/events/XaaBzwZXVNX47FASvJeogy?videoPreview=12023-02-09T02:00:00+00:003816.52Faculty of Business and EconomicsIt is our great privilege to welcome Kristina Potočnik to the Business School. Kristina is a leading Organizational Behaviour scholar and currently an associate editor at the Journal of Management Studies and International Journal of Selection and Assessment. She has kindly agreed to share her wisdom about: how to publish in elite Management journals, such as the Journal of Management Studies (JMS). We invite scholars of the Business School to join us for this workshop led by Kristina. This is a fantastic opportunity, particularly for emergent researchers and PhD students to get useful advice on how to prepare work for elite journals, how to make it beyond a desk reject, and how to eventually survive the review process.https://cassyni-user-files-prod.s3.amazonaws.com/FXveoEsfU9XdfNUYtriCVc https://cassyni.com/events/U82xgA2rRAeR5YrtGeGrA9/seminar/qa https://cassyni.com/slides/outline/U82xgA2rRAeR5YrtGeGrA9 https://cassyni.com/events/U82xgA2rRAeR5YrtGeGrA9/abstract https://cassyni-user-files-prod.s3.amazonaws.com/DJRMgweC31aw5jNgkZriAA https://cassyni.com/events/U82xgA2rRAeR5YrtGeGrA9?videoPreview=1 Cavitating flow in a venturi; insights from a multimodal approachnohttps://cassyni.com/events/U82xgA2rRAeR5YrtGeGrA9?videoPreview=12023-03-21T15:00:00+00:003372.24Experiments in FluidsIn an ongoing effort to study the fundamentals of partial cavitation, we use a benchmark flow (a cavitating venturi) and apply various imaging and flow measurement techniques. In this seminar, I will summarize some recent results using high-speed imaging, x-ray densitometry, tomographic PIV and magnetic resonance velocimetry. Each of these modalities provides an important piece of the puzzle; together they can be used to unravel the dynamics of the cavitating flow. With the complementary information, we can investigate the re-entrant jet flow, the strength of condensation shocks, and understand how these mechanisms compete in this highly dynamic multiphase flow.https://cassyni-user-files-prod.s3.amazonaws.com/DJRMgweC31aw5jNgkZriAA https://cassyni.com/events/7NoajSroywP9wZQbzXMWGd/seminar/qa https://cassyni.com/slides/outline/7NoajSroywP9wZQbzXMWGd https://cassyni.com/events/7NoajSroywP9wZQbzXMWGd/abstract https://cassyni-user-files-prod.s3.amazonaws.com/ReQGS2BspT9qQZtfiyzDXU https://cassyni.com/events/7NoajSroywP9wZQbzXMWGd?videoPreview=1 Netzero: Challenges for Aviation and for Structural Aircraft Designnohttps://cassyni.com/events/7NoajSroywP9wZQbzXMWGd?videoPreview=12023-06-06T11:00:00+00:003330.8Brahmal Vasudevan Institute for Sustainable AviationAchieving NetZero is of utmost importance for avoiding the worst effects of climate change, including frequency and intensity of natural disasters, as well as the associated socio-economic unrest and effect on our health. Aviation accounts for just over 2% of overall CO2 emissions worldwide (8% for the UK), and for about 4% of the warming effect. On current technology, aviation would use 27% of the total Carbon budget available to limit global warming to 1.5C by 2050; it would represent roughly 40% of the UK’s emissions by 2050 if other sectors decarbonise according to the government’s targets. Reducing the warming effect of aviation can be achieved via a combination of greener energy carriers (as alternatives to Jet Fuel), flight-path management, demand management, and carbon capture. Greener energy carriers, such as hydrogen, pose various challenges, including large-scale green energy production, distribution, airports and aircraft design. In fact, the timescale in which we need to explore design spaces suitable for hydrogen-powered aircraft, including high aspect ratio wings and blended-wing-body aircraft, require novel and more agile structural design methods, particularly for composite structures. Traditional structural design methods in Aeronautics explore a very large number of design variables using simple models, suitably calibrated following decades of experience, as well as extensive experimental and simulation data. More detailed finite element models are finally created to verify the design, but only once the design space has been very significantly reduced, and vast aspects of the design have been fixed. This process creates an obvious problem when moving away from the design space for which the simple models used at the start of this process were calibrated. A possible solution to the above consists of detailed finite element models of very large aircraft structures that have the capability to represent the detail required to predict likely hotspots in structural components such as a wing, and where the discretisation and the design variables can evolve during the analysis as required. Possible approaches for achieving such models will be presented during the talk. https://cassyni-user-files-prod.s3.amazonaws.com/ReQGS2BspT9qQZtfiyzDXU https://cassyni.com/events/Gm84cS9nKduRoJsjueq59F/seminar/qa https://cassyni.com/slides/outline/Gm84cS9nKduRoJsjueq59F https://cassyni.com/events/Gm84cS9nKduRoJsjueq59F/abstract https://cassyni-user-files-prod.s3.amazonaws.com/GdhVz2jaScaqdza84ajMJv https://cassyni.com/events/Gm84cS9nKduRoJsjueq59F?videoPreview=1 Solar water treatmentnohttps://cassyni.com/events/Gm84cS9nKduRoJsjueq59F?videoPreview=12023-06-08T10:00:00+00:003744.48ElsevierThe development of solar powered water treatment technologies had gained a lot of attention in the past decade with applications ranging from treatment of saline water for desalination purposes to treatment of wastewater. It is important to distinguish here between hybrid systems in-which an existing water treatment technology is coupled with an existing renewable energy technology, and other approaches in-which renewable energy such as solar energy is directly used for the treatment of water. An example of the latter is direct solar membrane distillation. In this seminar we will explore direct solar water treatment research with emphasis on solar membrane distillation. This will include recent findings in the field in addition to research gaps and future perspectives.https://cassyni-user-files-prod.s3.amazonaws.com/GdhVz2jaScaqdza84ajMJv https://cassyni.com/events/9MPzvBSujmbv3GgqMVDShB/seminar/qa https://cassyni.com/slides/outline/9MPzvBSujmbv3GgqMVDShB https://cassyni.com/events/9MPzvBSujmbv3GgqMVDShB/abstract https://cassyni-user-files-prod.s3.amazonaws.com/LdziUwNvoEehEpJNqdHh7c https://cassyni.com/events/9MPzvBSujmbv3GgqMVDShB?videoPreview=1 Viral spillover risk increases with climate change in High Arctic lake sedimentsnohttps://cassyni.com/events/9MPzvBSujmbv3GgqMVDShB?videoPreview=12023-05-15T14:00:00+00:001778.08Royal Society PublishingThe host spectrum of viruses is quite diverse, as they can sustainedly infect a few species to several phyla. When confronted with a new host, a virus may even infect it and transmit sustainably in this new host, a process called ‘viral spillover’. However, the risk of such events is difficult to quantify. As climate change is rapidly transforming environments, it is becoming critical to quantify the potential for spillovers. To address this issue, we resorted to a metagenomics approach and focused on two environments, soil and lake sediments from Lake Hazen, the largest High Arctic freshwater lake in the world. We used DNA and RNA sequencing to reconstruct the lake’s virosphere in both its sediments and soils, as well as its range of eukaryotic hosts. We then estimated the spillover risk by measuring the congruence between the viral and the eukaryotic host phylogenetic trees, and show that spillover risk increases with runoff from glacier melt, a proxy for climate change. Should climate change also shift species range of potential viral vectors and reservoirs northwards, the High Arctic could become fertile ground for emerging pandemics.https://cassyni-user-files-prod.s3.amazonaws.com/LdziUwNvoEehEpJNqdHh7c https://cassyni.com/slides/outline/Bpe29bgXw4NQQDAPuB85R7 https://cassyni.com/events/Bpe29bgXw4NQQDAPuB85R7/abstract https://cassyni-user-files-prod.s3.amazonaws.com/E6dzWztHR3sRCv8cgLaVpJ https://cassyni.com/events/Bpe29bgXw4NQQDAPuB85R7?videoPreview=1 How cells stay out of equilibrium by proliferating at high and frigid temperaturesnohttps://cassyni.com/events/Bpe29bgXw4NQQDAPuB85R7?videoPreview=12022-03-10T09:00:00+00:004714.32Journal of Biological PhysicsOne of the hallmarks of a living cell is that it can duplicate itself. An important question is when and why a cell might permanently lose its ability to proliferate and thereby transition into being a dead cell. The design principles that govern such 'life-to-death' transition remain incompletely understood. In this talk, I will describe two experimental studies in which we used the budding yeast, S. cerevisiae, to reveal such design principles in the context of high and frigid temperatures. Temperature is a universal parameter for life in that it controls the speed of all biochemical reactions in all organisms and every habitat. By either increasing the temperature to sufficiently high values or decreasing the temperature to sufficiently low values, we placed yeast cells at the edge of their capacity to duplicate. For both high temperatures (> 38 C) and near-freezing temperatures (0 C - 5 C), we found ways to extend yeast's ability to duplicate: we could enable more cells to duplicate with drastically shortened doubling times. We constructed 'phase diagrams' that describe cell-population growths for both temperature regimes. The same mathematical model, with one free parameter, reproduced both phase diagrams as well as stochastic proliferation of individual cells. At near-freezing temperatures, we discovered 'speed limits' - slowest and fastest possible doubling times - at which a yeast cell's life can progress: a cell that progresses more slowly than a 'low-speed limit' defined for each temperature faces a certain death. A mathematical model and experimental data elucidated how these speed limits arise. These findings establish a quantitative foundation for engineering organisms that can survive extreme temperatures and elucidating fundamental limits to slowing down life.https://cassyni-user-files-prod.s3.amazonaws.com/E6dzWztHR3sRCv8cgLaVpJ https://cassyni.com/slides/outline/JF4skV6Me1a6E2rrm5WV2D https://cassyni.com/events/JF4skV6Me1a6E2rrm5WV2D/abstract https://cassyni-user-files-prod.s3.amazonaws.com/QVYKkKB5AG6Xevp7ZNZiM4 https://cassyni.com/events/JF4skV6Me1a6E2rrm5WV2D?videoPreview=1 Turbulence: Reynolds Averaged Navier-Stokes (Part 1, Mass Continuity Equation)nohttps://cassyni.com/events/JF4skV6Me1a6E2rrm5WV2D?videoPreview=12021-04-02T12:00:00+00:001012.0Brunton LabOne of the most common strategies to model a turbulent fluid flow is to attempt to model the average, or mean flow field, by expanding the velocity field into an average and a fluctuating component. This video introduces this idea of 'Reynolds averaging' and shows how to obtain a mass continuity equation for the mean flow.https://cassyni-user-files-prod.s3.amazonaws.com/QVYKkKB5AG6Xevp7ZNZiM4 https://cassyni.com/slides/outline/EHt3P1vA8M8wSNQBMxvSRK https://cassyni.com/events/EHt3P1vA8M8wSNQBMxvSRK/abstract https://cassyni-user-files-prod.s3.amazonaws.com/JDGe2Li1AJpFf47sZwasen https://cassyni.com/events/EHt3P1vA8M8wSNQBMxvSRK?videoPreview=1 Mathematical modelling of inertial particle migration in curved microfluidic ductsnohttps://cassyni.com/events/EHt3P1vA8M8wSNQBMxvSRK?videoPreview=12023-05-02T23:00:00+00:003112.36Journal of Engineering MathematicsParticles suspended in flow through a closed duct migrate in the cross section of the duct due to the forces acting on them and may focus to different equilibrium positions in the cross section. This has been used for particle sorting in microfluidic devices, one example being "liquid biopsy", the isolation of circulating tumour cells from a blood sample. In this talk we will consider the migration of spherical neutrally-buoyant particles in curved microfluidic ducts. In addition to the primary flow along the duct, the curvature results in Dean vortices in the cross section. Particle migration is due to a balance between the inertial lift arising, primarily, from the flow along the duct, and drag arising from the cross-sectional vortices. In a spiral duct, the changing bend radius results in bifurcations in the particle equilibria and consequential changes in the particle dynamics, so that different spirals yield different outcomes. Recent mathematical modelling, aimed at predicting the migration of a spherical particle in such ducts under the assumptions that the particle Reynolds number is small and the bend radius of the duct changes slowly, will be discussed. The goal is to develop a model that might be used to determine a duct geometry for a specific application requiring separation of particles of different size. This is joint work with Dr Brendan Harding, Dr Rahil Valani, Dr Kyung Ha and Prof Andrea Bertozzi.https://cassyni-user-files-prod.s3.amazonaws.com/JDGe2Li1AJpFf47sZwasen https://cassyni.com/events/QAskRKNYJs8zSN6cA6dFBs/seminar/qa https://cassyni.com/slides/outline/QAskRKNYJs8zSN6cA6dFBs https://cassyni.com/events/QAskRKNYJs8zSN6cA6dFBs/abstract https://cassyni-user-files-prod.s3.amazonaws.com/WdpumFzL7WJeMcSkvM3Dgi https://cassyni.com/events/QAskRKNYJs8zSN6cA6dFBs?videoPreview=1 Cancer-associated fibroblastsnohttps://cassyni.com/events/QAskRKNYJs8zSN6cA6dFBs?videoPreview=12023-06-07T15:00:00+00:005802.16Research Seminars by Springer NatureThis webinar will focus on Cancer-associated fibroblasts. Our panelists will discuss developments in this exciting research field and their global perspectives. Prof Neta Erez will be speaking about how stromal plasticity shapes the metastatic microenvironment and Dr Ruth Scherz-Shouval will be speaking about cancer-CAF coevolution. Dr. Fatima Mechta-Grigoriou will be speaking about the role of CAF heterogeneity in immunosuppression and resistance to immunotherapy in cancer. Dr. Alexandre Calon will discuss how CAFs influence the response to anti-tumor therapy. The webinar will be hosted by [Nature Communications](https://www.nature.com/ncomms/) editors.https://cassyni-user-files-prod.s3.amazonaws.com/WdpumFzL7WJeMcSkvM3Dgi https://cassyni.com/events/KEPhxUuHvHby3GPG9cvFTj/seminar/qa https://cassyni.com/slides/outline/KEPhxUuHvHby3GPG9cvFTj https://cassyni.com/events/KEPhxUuHvHby3GPG9cvFTj/abstract https://cassyni-user-files-prod.s3.amazonaws.com/QzRzwYv1x9LvV5NanGpVGa https://cassyni.com/events/KEPhxUuHvHby3GPG9cvFTj?videoPreview=1 Prediction of Spray Vapor Tip Penetration of Diesel, Biodiesel and Synthetic Fuels Using Artificial Neural Networks with Confidence Intervalsnohttps://cassyni.com/events/KEPhxUuHvHby3GPG9cvFTj?videoPreview=12023-06-30T09:00:00+00:001930.52Cassyni SeminarsFuel spray and atomization processes affect the combustion and emissions characteristics of fuels in internal combustion engines. Biodiesel and synthetic fuels such as oxymethylene dimethyl ethers (OME) show great promise as alternative fuels and are complementary in terms of reproducing the fluid properties of conventional diesel fuels through blending, for instance. Averaged experimental results, empirical correlations and Computational Fluid Dynamics (CFD) have typically been used to evaluate and predict fuel spray liquid and vapor penetration values so as to better design internal combustion engines. Lately, Machine Learning (ML) is being applied to these investigations. Typically, ML spray studies use averaged experimental data and then over-trained neural networks on the limited available data. By contrast, in this study we present spray vapor tip penetration predictions using artificial neural networks with systematic treatment of uncertainties arising from experimental variability and limitations in the neural network training process. This has not been presented previously, and it allows the calculation of confidence intervals on the spray penetration predictions produced by neural networks. Using the present method, we evaluate four different diesel, biodiesel and OME fuel blends under four fuel injection conditions each and predict spray vapor tip penetration values with a correlation coefficient of 0.999. Across all fuel variants and injection conditions, one standard deviation represented less than 1.5 mm spray tip penetration (circa 2% of spray tip penetration) 1 ms from the start of injection. Despite this precision, a 95% confidence interval on neural network predictions encompassed the experimental fuel penetration data across all fuel variants, injection conditions and time steps. By calculating the confidence intervals on neural network predictions, we enable internal combustion engine designers to better quantify the applicability of neural networks in predicting spray characteristics.https://cassyni-user-files-prod.s3.amazonaws.com/QzRzwYv1x9LvV5NanGpVGa https://cassyni.com/events/5QEnfLnbdU6VQ5vZEwZqiu/seminar/qa https://cassyni.com/slides/outline/5QEnfLnbdU6VQ5vZEwZqiu https://cassyni.com/events/5QEnfLnbdU6VQ5vZEwZqiu/abstract https://cassyni-user-files-prod.s3.amazonaws.com/63jSkeybn3xdwHk7yPyKcA https://cassyni.com/events/5QEnfLnbdU6VQ5vZEwZqiu?videoPreview=1 What is Algebraic Combinatorics and What Should it Be?nohttps://cassyni.com/events/5QEnfLnbdU6VQ5vZEwZqiu?videoPreview=12023-07-26T15:30:00+00:003335.96The Journal of Algebraic CombinatoricsI will survey the history and trends of this relatively new field, and speculate about the future, and discuss what it SHOULD be, but also what it should NOT be.https://cassyni-user-files-prod.s3.amazonaws.com/63jSkeybn3xdwHk7yPyKcA https://cassyni.com/events/Vc1PvqVK8uEPZmgQAis99F/seminar/qa https://cassyni.com/slides/outline/Vc1PvqVK8uEPZmgQAis99F https://cassyni.com/events/Vc1PvqVK8uEPZmgQAis99F/abstract https://cassyni-user-files-prod.s3.amazonaws.com/RDfXjz5pkkV9SDkYqpGfk2 https://cassyni.com/events/Vc1PvqVK8uEPZmgQAis99F?videoPreview=1 Frontiers in plant–microbe interactions - part 1nohttps://cassyni.com/events/Vc1PvqVK8uEPZmgQAis99F?videoPreview=12023-06-13T08:00:00+00:005596.88New PhytologistWe present an exciting two-part webinar highlighting the latest research in plant–microbe interactions, hosted by Francis Martin. Following the recent publication of our collection on the ‘[Impact of global change on the plant microbiome ](https://nph.onlinelibrary.wiley.com/toc/14698137/2022/234/6)’, and ahead of the forthcoming special issue on '[Mycorrhizal research now: from micro-to macro scale](https://www.newphytologist.org/news/view/326)’, these webinars will explore the latest research on the fascinating and complex relationships between plants and microbes. Leading researchers will share their insights into the molecular mechanisms that underlie the symbiotic relationships between plants and different types of microbes, including nodulating bacteria, endophytes, and mycorrhizal fungi. Part 2 will be held on 15 June This will be held on Zoom Webinar you can access the webinar here on Cassyni, or register on [Eventbrite](https://www.eventbrite.com/e/new-phytologist-now-frontiers-in-plantmicrobe-interactions-part-1-registration-634728288397?aff=odcleoeventsincollection&keep_tld=1) to get the zoom link via email. https://cassyni-user-files-prod.s3.amazonaws.com/RDfXjz5pkkV9SDkYqpGfk2 https://cassyni.com/slides/outline/UciBqUCGFz8Eu1rQ4kPpLM https://cassyni.com/events/UciBqUCGFz8Eu1rQ4kPpLM/abstract https://cassyni-user-files-prod.s3.amazonaws.com/VT28ptgC9UQoS4vEZdhxWJ https://cassyni.com/events/UciBqUCGFz8Eu1rQ4kPpLM?videoPreview=1 Diagnostic and therapeutic implications of IDH mutations in gliomas following the 2021 World Health Organization classification of CNS tumorsnohttps://cassyni.com/events/UciBqUCGFz8Eu1rQ4kPpLM?videoPreview=12023-06-05T20:00:00+00:002120.68Journal of Neuro-OncologyJoin Dr. Randy D'Amico and Dr. Jason Sheehan from the Journal of Neuro-Oncology for a conversation with Prof. Dr. med. Tareq Juratli, FEBNS (Technical University Dresden), Michael Parsons, PhD (Massachusetts General Hospital), and PD Dr. med. Laila König (Universität Heidelberg) about their latest journal article, "Diagnostic and therapeutic implications of IDH mutations in gliomas following the 2021 World Health Organization classification of CNS tumors."https://cassyni-user-files-prod.s3.amazonaws.com/VT28ptgC9UQoS4vEZdhxWJ https://cassyni.com/events/HFputNq5ZpKJW6V4Msjv9B/seminar/qa https://cassyni.com/slides/outline/HFputNq5ZpKJW6V4Msjv9B https://cassyni.com/events/HFputNq5ZpKJW6V4Msjv9B/abstract https://cassyni-user-files-prod.s3.amazonaws.com/9dBTwd4Ngu9NaKcxrhE7wc https://cassyni.com/events/HFputNq5ZpKJW6V4Msjv9B?videoPreview=1 Formulation and demonstrations of three-dimensional background-oriented schlieren using a mirror for near-wall density measurements, TrackAER: real-time event-based quantitative flow visualizationnohttps://cassyni.com/events/HFputNq5ZpKJW6V4Msjv9B?videoPreview=12023-10-10T14:00:00+00:001755.32Experiments in FluidsThree-dimensional background-oriented schlieren (3D-BOS) is an effective method for reconstructing 3D density fields from optically measured data, but it has limitations in measuring near-wall regions, where most of the light paths are blocked. This paper proposes a new extension, 3D-BOS using Mirror, which uses a wall as a mirror to provide sufficient light paths. In this paper, first, the conventional formulations are modified for the proposed method to handle the mirror reflections of the light paths. Subsequently, the proposed method is validated using artificially generated model data of an ideal axisymmetric distribution. The proposed method can reconstruct the distribution as accurately as the conventional method for all the number of cameras examined. Finally, the proposed method is experimentally demonstrated using a candle plume. The proposed method can capture cylindrical low-density regions near the wall surface. We present a novel event-based quantitative flow visualization system, TrackAER, capable of continuously reconstructing, rendering and recording particle tracks in large test volumes without limitations on the measurement duration. Multiple event-based cameras are synchronized and calibrated to produce independent and asynchronous, yet temporally co-registered data streams of flow tracer positions. Subsequently, these data streams are merged into time-resolved three-dimensional particle tracks using photogrammetric techniques. Due to the operating principle of event cameras, the flow scenery is reduced to moving objects only, which effectively compresses the data stream at the camera source. In combination with an efficient data processing pipeline, the measurement system operates in real-time, reconstructing and rendering the investigated flow field without noticeable time lag. The data processing approach follows a “per-event” paradigm and enables the immediate observation and analysis of both, transient and long duration flow features. Specific issues resulting from event-based, frame-free processing are discussed as well as the advantages and limitations of event cameras. Exemplary results are provided to demonstrate the utility of the TrackAER system where Lagrangian particle track information is displayed in a virtual scene together with extracted quantitative information such as local flow velocities.https://cassyni-user-files-prod.s3.amazonaws.com/9dBTwd4Ngu9NaKcxrhE7wc https://cassyni.com/events/4QwaZyVYkYzLjL6Z8y6Wv1/seminar/qa https://cassyni.com/slides/outline/4QwaZyVYkYzLjL6Z8y6Wv1 https://cassyni.com/events/4QwaZyVYkYzLjL6Z8y6Wv1/abstract https://cassyni-user-files-prod.s3.amazonaws.com/JLJaacHHohPbAzqiHcUeSS https://cassyni.com/events/4QwaZyVYkYzLjL6Z8y6Wv1?videoPreview=1 Session 5: Integration / certificationnohttps://cassyni.com/events/4QwaZyVYkYzLjL6Z8y6Wv1?videoPreview=12023-10-06T07:30:00+00:003690.88Brahmal Vasudevan Institute for Sustainable Aviation at Imperial College London**Chair: Moti Karpel (Technion)**https://cassyni-user-files-prod.s3.amazonaws.com/JLJaacHHohPbAzqiHcUeSS https://cassyni.com/events/EnZGYL5ZyAcmFqPhA53QbX/seminar/qa https://cassyni.com/slides/outline/EnZGYL5ZyAcmFqPhA53QbX https://cassyni.com/events/EnZGYL5ZyAcmFqPhA53QbX/abstract https://cassyni-user-files-prod.s3.amazonaws.com/HxnkgU2m5F3nmhn1svzybL https://cassyni.com/events/EnZGYL5ZyAcmFqPhA53QbX?videoPreview=1 From moving masses to bending spaces: an excursion in metric geometrynohttps://cassyni.com/events/EnZGYL5ZyAcmFqPhA53QbX?videoPreview=12023-07-10T13:00:00+00:003210.0Springer Nature WebinarsIn this new session, Camillo De Lellis will interview Nicola Gigli about his personal journey out and in mathematics, how he came to choose the topics of his research and why he is excited about them. During the conversation the speakers will explain the connection between the concepts of optimal transport and curvature of a space, a discovery which has given birth to a new, fast growing research field, at the intersection of several areas of mathematics.https://cassyni-user-files-prod.s3.amazonaws.com/HxnkgU2m5F3nmhn1svzybL https://cassyni.com/slides/outline/Kj4w7o4hm75ns2xcuZeYs7 https://cassyni.com/events/Kj4w7o4hm75ns2xcuZeYs7/abstract https://cassyni-user-files-prod.s3.amazonaws.com/DrvucUZRzgTdFEoMeptfw4 https://cassyni.com/events/Kj4w7o4hm75ns2xcuZeYs7?videoPreview=1 Continuum models for granular statics and flow: How particle simulations can help in build them and verify the principles that underpin themnohttps://cassyni.com/events/Kj4w7o4hm75ns2xcuZeYs7?videoPreview=12023-01-24T12:00:00+00:005170.92Granular MatterWe have today the ability to numerically simulate the dynamics of millions of grains, but unless the simulation results are distilled to a continuum theory, we would not have understood the mechanics. In this talk, I will argue that by asking the right questions and using relatively simple analysis, one can use particle simulations to build models and develop an understanding. I will consider two problems, one in granular statics and another in slow flow, and demonstrate how we have used particle simulations to achieve a fundamental understanding of granular mechanics. In granular statics, such an understanding leads to a closure relation for the stress. In slow flow, it provides explanations for the basic principles that underpin continuum models. I will then show experimental verification of the key ideas distilled from the simulations.https://cassyni-user-files-prod.s3.amazonaws.com/DrvucUZRzgTdFEoMeptfw4 https://cassyni.com/slides/outline/Y5H3GtEpjYvekiCRsvDH1F https://cassyni.com/events/Y5H3GtEpjYvekiCRsvDH1F/abstract https://cassyni-user-files-prod.s3.amazonaws.com/BhCfZrAoHn5DqgoARPpEHt https://cassyni.com/events/T8nzp3maLyPdMcV5sSWHH7/seminar/qa https://cassyni.com/slides/outline/T8nzp3maLyPdMcV5sSWHH7 https://cassyni.com/events/T8nzp3maLyPdMcV5sSWHH7/abstract https://cassyni-user-files-prod.s3.amazonaws.com/GPnNaExfRX9EPxX57FuoLS https://cassyni.com/events/T8nzp3maLyPdMcV5sSWHH7?videoPreview=1 On rearrangement inequalities for triangular norms and co-norms in multi-valued logicnohttps://cassyni.com/events/T8nzp3maLyPdMcV5sSWHH7?videoPreview=12023-08-23T14:00:00+00:002929.08Logica UniversalisThe rearrangement inequality states that the sum of products of permutations of 2 sequences of real numbers are maximized when the terms are similarly ordered and minimized when the terms are ordered in opposite order. We show that similar inequalities exist in algebras of multi-valued logic when the multiplication and addition operations are replaced with various T-norms and T-conorms respectively. For instance, we show that the rearrangement inequality holds when the T-norms and T-conorms are derived from Archimedean copulas.https://cassyni-user-files-prod.s3.amazonaws.com/GPnNaExfRX9EPxX57FuoLS https://cassyni.com/slides/outline/5tv1pex1UHaKDrVuztJ98H https://cassyni.com/events/5tv1pex1UHaKDrVuztJ98H/abstract https://cassyni-user-files-prod.s3.amazonaws.com/AAhXnwNw8GZ9X96B3fQHUA https://cassyni.com/events/5tv1pex1UHaKDrVuztJ98H?videoPreview=1 Generation and Detection of Deepfakesnohttps://cassyni.com/events/5tv1pex1UHaKDrVuztJ98H?videoPreview=12022-03-03T12:30:00+00:003059.92Journal on Image and Video ProcessingGenerative adversarial networks have made remarkable progress in generating realistic images of high quality. While video generation is the natural sequel, it entails a number of challenges w.r.t. complexity and computation, associated to the simultaneous modeling of appearance, as well as motion. I will talk about our work related to design of generative models, which allow for realistic generation of face images and videos. We have placed emphasis on disentangling motion from appearance and have learned motion representations directly from RGB, without structural representations such as facial landmarks or 3D meshes. In our latest work, we have aimed at constructing motion as linear displacement of codes in the latent space. Based on this, our model LIA (Latent Image Animator) is able to animate images via navigation in the latent space. While highly intriguing, video generation has thrusted upon us the imminent danger of deepfakes, which can offer unprecedented levels of increasingly realistic manipulated videos. Deepfakes pose an imminent security threat to us all, and to date, deepfakes are able to mislead face recognition systems, as well as humans. Hence, we design generation and detection methods in parallel. In the second part of my talk, I will discuss our associated work, where in our latest work, we explore attention mechanisms in 3D CNNs. https://cassyni-user-files-prod.s3.amazonaws.com/AAhXnwNw8GZ9X96B3fQHUA https://cassyni.com/events/2SNnVsRLQ5hgCACMMDvBbT/seminar/qa https://cassyni.com/events/2SNnVsRLQ5hgCACMMDvBbT/abstract https://cassyni-user-files-prod.s3.amazonaws.com/5rV7hbfuvb6Coft8YNDuRG https://cassyni.com/events/2SNnVsRLQ5hgCACMMDvBbT?videoPreview=1 Session 8: Wrap-up and look aheadnohttps://cassyni.com/events/2SNnVsRLQ5hgCACMMDvBbT?videoPreview=12023-10-06T14:00:00+00:00914.88Brahmal Vasudevan Institute for Sustainable Aviation at Imperial College LondonThis is an opportunity to revisit the main challenges and opportunities associated with HARW concepts for highly-efficient aircraft, and the next steps needed to advance its feasibility into future aircraft programs.https://cassyni-user-files-prod.s3.amazonaws.com/5rV7hbfuvb6Coft8YNDuRG https://cassyni.com/events/4ucojHexbNUAZ6futuppKP/seminar/qa https://cassyni.com/slides/outline/4ucojHexbNUAZ6futuppKP https://cassyni.com/events/4ucojHexbNUAZ6futuppKP/abstract https://cassyni-user-files-prod.s3.amazonaws.com/22dSP3fKssr85d7V25HFB4 https://cassyni.com/events/4ucojHexbNUAZ6futuppKP?videoPreview=1 Commercialising bioengineering research: Lessons learnt from the Formus journeynohttps://cassyni.com/events/4ucojHexbNUAZ6futuppKP?videoPreview=12023-09-12T04:00:00+00:003756.04The Auckland Bioengineering InstituteFormus Labs, an ABI-spinout company, recently received FDA clearance for its orthopaedic pre-operative orthopaedic planning software and is looking to expand in the US and Japanese markets later in the year. Our recent success at the NZ HiTech Awards acknowledged the achievement of the team in bringing a medical technology to market, but behind the scenes this has been a long journey and one that stemmed from decades of academic research. This talk reflects on some of the opportunities, decisions, and lessons leant along this path to commercialisation. https://cassyni-user-files-prod.s3.amazonaws.com/22dSP3fKssr85d7V25HFB4 https://cassyni.com/events/DJe5Wuet49t9iS2Nxm9sYH/abstract https://cassyni-user-files-prod.s3.amazonaws.com/QzqGXSqPoSSw5prSjQV4BY https://cassyni.com/events/PBdnZD7GEftCiRioktrgJq/seminar/qa https://cassyni.com/slides/outline/PBdnZD7GEftCiRioktrgJq https://cassyni.com/events/PBdnZD7GEftCiRioktrgJq/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Wis1osd5CM2RYCFNLRymTk https://cassyni.com/events/PBdnZD7GEftCiRioktrgJq?videoPreview=1 Particle fragmentation in granular materialsnohttps://cassyni.com/events/PBdnZD7GEftCiRioktrgJq?videoPreview=12023-10-25T14:00:00+00:003743.04Granular MatterParticle fragmentation plays an important role in natural granular flows, soil microstructure evolution, and powder-based industrial processes. The energetic inefficiency of comminution and effects of particle breakage on the strength properties of soils and rockfills are among old issues that have remained poorly understood mainly because of the multiscale nature of the particle breakage process in granular materials. Along with modern experimental tools such as tomography, new insights can however be expected from particle dynamics simulations coupled with methods accounting for crack nucleation and propagation inside the particles. In this seminar, I will use several examples to illustrate the potential of this particlebased approach, allowing me also to discuss several aspects of particle fragmentation in granular materials: 1) Breakage of a single particle and its scaling with impact energy, 2) Evolution of particle size distribution in cascading flows in a rotating drum and its scaling with system parameters, 3) Evolution of particle size distribution in quasi-static flows and its effect on the rheology, 4) Population balance model and cushioning effect, and 5) Self-similar fragment size distributions and particle shapes arising from both single-particle and collective particle breakage. https://cassyni-user-files-prod.s3.amazonaws.com/Wis1osd5CM2RYCFNLRymTk https://cassyni.com/slides/outline/CKLsRYMqBEn13gCNrngYjP https://cassyni.com/events/CKLsRYMqBEn13gCNrngYjP/abstract https://cassyni-user-files-prod.s3.amazonaws.com/2GxEuPV66c8Av7m3GqsWSr https://cassyni.com/events/CKLsRYMqBEn13gCNrngYjP?videoPreview=1 Mixed gas diving: physiological challengesnohttps://cassyni.com/events/CKLsRYMqBEn13gCNrngYjP?videoPreview=12023-10-10T03:00:00+00:003699.6The Auckland Bioengineering InstituteRecreational scuba divers venture underwater to explore the underwater world or perform jobs like monitoring, data collection or just sightseeing. Deeper and longer divers increase the complexity of diving, like additional and different gases, more equipment and increased planning. These complex dives also increase the levels of physiological exposure. Divers are taught how to manage the risks of physiological challenges like decompression, hypercapnia, hypoxia, hyperoxia, nitrogen narcosis and hypothermia. Xavier will discuss these physiological challenges and the technological possibilities and opportunities to monitor or overcome them.https://cassyni-user-files-prod.s3.amazonaws.com/2GxEuPV66c8Av7m3GqsWSr https://cassyni.com/slides/outline/HkW93gzVQdo8KZUa9yrtKP https://cassyni.com/events/HkW93gzVQdo8KZUa9yrtKP/abstract https://cassyni-user-files-prod.s3.amazonaws.com/E1GUQjZ9K9VgbgLecbJ2Jz https://cassyni.com/events/HkW93gzVQdo8KZUa9yrtKP?videoPreview=1 Introducing Transformative Plant Biotechnology: Anthocyanin synthesis in tomato fruit is regulated by a photo-thermal switch controlled by COP1 and HY5 factorsnohttps://cassyni.com/events/HkW93gzVQdo8KZUa9yrtKP?videoPreview=12023-09-20T16:00:00+00:00708.4The New Phytologist FoundationAnthocyanins are polyphenols responsible for fruit coloration and beneficial for human health. The tomato line “Sunblack” can synthesize anthocyanins in the fruit peel under light, resulting in black fruits. This phenotype is due to specific alleles of MybAtv and Aft genes. Interestingly, temperature plays a crucial role in pigmentation during fruit development: at 23°C fruits can become completely black, at 28°C anthocyanin accumulation is strongly inhibited. To investigate this temperature-dependent process, we focused on the two major players of the light-signaling pathway. COP1 is a negative regulator and tags its targets for degradation under dark. HY5 acts as a master-positive regulator of photomorphogenesis activating transcription of biosynthetic and regulatory genes under light, included many involved in anthocyanin synthesis. Here, we speculate that COP1 levels can increase with temperature, even when fruits are exposed to light, thus degrading HY5, and inhibiting anthocyanin production. To demonstrate this, we evaluated under different conditions the content of COP1 and HY5 in the fruit exocarp, compared their gene expressions as well as their possible targets in anthocyanin synthesis. Our study sheds light on temperature-dependent regulation of anthocyanin synthesis in tomato and provides new insights into the complex interplay between light- and temperature-signaling during fruit development. **Co-Authors**: S.Gonzali, P. Peratahttps://cassyni-user-files-prod.s3.amazonaws.com/E1GUQjZ9K9VgbgLecbJ2Jz https://cassyni.com/events/W6iFCnAcP5dzDEiP8LRcTX/seminar/qa https://cassyni.com/slides/outline/W6iFCnAcP5dzDEiP8LRcTX https://cassyni.com/events/W6iFCnAcP5dzDEiP8LRcTX/abstract https://cassyni-user-files-prod.s3.amazonaws.com/5fukrwciKgSHTJuAvswa1C https://cassyni.com/events/W6iFCnAcP5dzDEiP8LRcTX?videoPreview=1 Nature Water Talks: Sanitation for allnohttps://cassyni.com/events/W6iFCnAcP5dzDEiP8LRcTX?videoPreview=12023-11-16T12:30:00+00:003570.2Nature WaterAccording to the UN, 4.2 billion people, that is, more than 50% of the world’s population, lack access to safely managed sanitation. As part of SDG6, we should aim to achieve safely managed sanitation for all by 2030. But how are we going to do that? And how do we even define safely managed sanitation? We’ll be talking about this and other aspects of sanitation with Jillian Maxcy-Brown (University of Alabama), Michael Templeton (Imperial College London) and Sonia Grego (Duke University).https://cassyni-user-files-prod.s3.amazonaws.com/5fukrwciKgSHTJuAvswa1C https://cassyni.com/slides/outline/TdUDyMvzBnsTB5UbfYdFTK https://cassyni.com/events/TdUDyMvzBnsTB5UbfYdFTK/abstract https://cassyni-user-files-prod.s3.amazonaws.com/QBKzSRtXtoYkAHwFoU6uW6 https://cassyni.com/events/TdUDyMvzBnsTB5UbfYdFTK?videoPreview=1 Advances in cancer photo-theranostics: the synergistic combination of transition metal complexes and gold nanostructuresnohttps://cassyni.com/events/TdUDyMvzBnsTB5UbfYdFTK?videoPreview=12021-04-26T12:00:00+00:001977.84Discover Applied SciencesIn this mini review, we highlight advances in the last five years in light-activated cancer theranostics by using hybrid systems consisting of transition metal complexes (TMCs) and plasmonic gold nanostructures (AuNPs). TMCs are molecules with attractive properties and high potential in biomedical application. Due to their antiproliferative abilities, platinum-based compounds are currently first-choice drugs for the treatment of several solid tumors. Moreover, ruthenium, iridium and platinum complexes are well-known for their ability to photogenerate singlet oxygen, a highly cytotoxic reactive species with a key role in photodynamic therapy. Their potential is further extended by the unique photophysical properties, which make TMCs particularly suitable for bioimaging. Recently, gold nanoparticles (AuNPs) have been widely investigated as one of the leading nanomaterials in cancer theranostics. AuNPs—being an inert and highly biocompatible material—represent excellent drug delivery systems, overcoming most of the side effects associated with the systemic administration of anticancer drugs. Furthermore, due to the thermoplasmonic properties, AuNPs proved to be efficient nano-sources of heat for photothermal therapy application. Therefore, the hybrid combination TMC/AuNPs could represent a synergistic merger of multiple functionalities for combinatorial cancer therapy strategies. Herein, we report the most recent examples of TMC/AuNPs systems in in-vitro in-vivo cancer tharanostics application whose effects are triggered by light-exposure in the Vis–NIR region, leading to a spatial and temporal control of the TMC/AuNPs activation for light-mediated precision therapeutics.https://cassyni-user-files-prod.s3.amazonaws.com/QBKzSRtXtoYkAHwFoU6uW6 https://cassyni.com/events/3RhchsEGgMjZ1PikjmKx2y/seminar/qa https://cassyni.com/slides/outline/3RhchsEGgMjZ1PikjmKx2y https://cassyni.com/events/3RhchsEGgMjZ1PikjmKx2y/abstract https://cassyni-user-files-prod.s3.amazonaws.com/3kMYXwWmdQ8e8yfoGLnhgJ https://cassyni.com/events/3RhchsEGgMjZ1PikjmKx2y?videoPreview=1 An investigation on space debris of unknown origin using proper elements and neural networks, Theory and applications of fast Lyapunov indicators to model problems of celestial mechanicsnohttps://cassyni.com/events/3RhchsEGgMjZ1PikjmKx2y?videoPreview=12023-12-01T14:00:00+00:004054.32Celestial Mechanics and Dynamical AstronomyProper elements represent a dynamical fingerprint of an object’s inherent state and have been used by small-body taxonomists in characterizing asteroid families. Being linked to the underlying dynamical structure of orbits, Celletti, Pucacco, and Vartolomei have recently adopted these innate orbital parameters for the association of debris from breakup or collision into its parent satellite. Building from this rich astronomical heritage and recent foundations, we introduce an unsupervised learning method—density-based spatial clustering of applications with noise (DBSCAN)—to determine clusters of orbital debris in the space of proper elements. Data is taken from the space-object catalog of trackable Earth-orbiting objects in the form of two-line element sets. Proper elements for debris fragments in low-Earth orbit are computed using an ad hoc numerical scheme, akin to the state-of-the-art Fourier-series-based synthetic method for the asteroid domain. Given the heuristic nature of classical DBSCAN, we investigate the use of neural networks, trained on known families, to augment DBSCAN into a classification problem and apply it to analyst objects of unknown origin. In the last decades, we have seen a rapid increment in the use of finite-time chaos indicators in celestial mechanics. They have been used to analyze the complex dynamics of planetary systems, of minor planets and of space debris. In fact, theoretical studies on fundamental dynamical models have revealed that, computed on short time intervals, they allow to efficiently detect resonances, represent the phase portraits of complex dynamics, compute center-stable-unstable manifolds as well as Lagrangian coherent structures. In this seminar, we focus on applications of the fast Lyapunov indicator (FLI) and review through examples why its computation is particularly powerful for those systems whose solutions may have an asymptotic behavior very different from the short-term one, as it is the case of sequences of close encounters in gravitational systems and the advection of particles in aperiodic flows. The main case study which is considered is the computation of the manifold tubes and the related transit orbits in the restricted three-body problem. https://cassyni-user-files-prod.s3.amazonaws.com/3kMYXwWmdQ8e8yfoGLnhgJ https://cassyni.com/slides/outline/Cp26arXF24Fps9BtetoWub https://cassyni.com/events/Cp26arXF24Fps9BtetoWub/abstract https://cassyni-user-files-prod.s3.amazonaws.com/7HEyHAkfuj8gk1qFg9bVTU https://cassyni.com/events/Cp26arXF24Fps9BtetoWub?videoPreview=1 Droplet dynamics in the presence of gas nanofilms: merging, wetting, bouncing & levitationnohttps://cassyni.com/events/Cp26arXF24Fps9BtetoWub?videoPreview=12021-10-06T14:00:00+00:002921.4Leeds Institute for Fluid DynamicsRecent advances in experimental techniques have enabled remarkable discoveries and insight into how the dynamics of thin gas/vapour films can profoundly influence the behaviour of liquid droplets: drops impacting solids can “skate on a film of air” [1], so that they can “bounce off walls” [2,3]; reductions in ambient gas pressure can suppress splashing [4] and initiate the merging of colliding droplets [5]; and evaporating droplets can levitate on their own vapour film [7] (the Leidenfrost effect). Despite these advances, the precise physical mechanisms governing these phenomena remains a topic of debate. A theoretical approach would shed light on these issues, but due to the strongly multiscale nature of these processes, brute force computation is infeasible. Furthermore, when films reach the scale of the mean free path in the gas (i.e. ~100nm) and below, new nanoscale physics appears that renders the classical Navier-Stokes paradigm inaccurate. In this talk, I will overview our development of efficient computational models for the aforementioned droplet dynamics in the presence of gas nanofilms into which gas-kinetic, van der Waals and/or evaporative effects can be easily incorporated [8,9]. It will be shown that these models can reproduce experimental observations – for example, the threshold between bouncing and wetting for drop impact on a solid is reproduced to within 5%, whilst a model excluding either gas-kinetic or van der Waals effects is ~170% off! These models will then be exploited to make new experimentally-verifiable predictions, such as how we expect drops to behave in reduced pressure environments. Finally, I will conclude with some exciting directions for future work.https://cassyni-user-files-prod.s3.amazonaws.com/7HEyHAkfuj8gk1qFg9bVTU https://cassyni.com/slides/outline/MD4zV733tCbYAxEm1K51m7 https://cassyni.com/events/MD4zV733tCbYAxEm1K51m7/abstract https://cassyni-user-files-prod.s3.amazonaws.com/QZM2mE8pXE4P4oykS4GYwY https://cassyni.com/events/MD4zV733tCbYAxEm1K51m7?videoPreview=1 Large-scale flows in turbulent convection: direct numerical simulations and machine learning modelsnohttps://cassyni.com/events/MD4zV733tCbYAxEm1K51m7?videoPreview=12021-12-02T12:00:00+00:003031.12Leeds Institute for Fluid DynamicsNo abstracthttps://cassyni-user-files-prod.s3.amazonaws.com/QZM2mE8pXE4P4oykS4GYwY https://cassyni.com/events/WbPUN6L2Du7p2hhtvSYadj/seminar/qa https://cassyni.com/slides/outline/WbPUN6L2Du7p2hhtvSYadj https://cassyni.com/events/WbPUN6L2Du7p2hhtvSYadj/abstract https://cassyni-user-files-prod.s3.amazonaws.com/LqXweWEjAZLWvD2zNbk9tz https://cassyni.com/events/WbPUN6L2Du7p2hhtvSYadj?videoPreview=1 Dynamic Oppositional Symmetries for Color, Jungian and Kantian Categoriesnohttps://cassyni.com/events/WbPUN6L2Du7p2hhtvSYadj?videoPreview=12023-12-13T15:00:00+00:004368.76Logica UniversalisThis paper investigates some classical oppositional categories, like synthetic vs. analytic, posterior vs. prior, imagination vs. grammar, metaphor vs. hermeneutic, metaphysics vs. observation, innovation vs. routine, and image vs. sound, and the role they play in epistemology and philosophy of science. The epistemological framework of objective cognitive constructivism is of special interest in these investigations. Oppositional relations are formally represented using algebraic lattice structures like the cube and the hexagon of opposition, with applications in the contexts of modern color theory, Kantian philosophy, Jungian psychology, and linguistics. https://cassyni-user-files-prod.s3.amazonaws.com/LqXweWEjAZLWvD2zNbk9tz https://cassyni.com/slides/outline/LDmnPjk11HVPWCQkuLbgxD https://cassyni.com/events/LDmnPjk11HVPWCQkuLbgxD/abstract https://cassyni-user-files-prod.s3.amazonaws.com/A1yMeMRV9oynFgHA8oFNqU https://cassyni.com/events/LDmnPjk11HVPWCQkuLbgxD?videoPreview=1 Turbulent wave-balance exchanges in the oceannohttps://cassyni.com/events/LDmnPjk11HVPWCQkuLbgxD?videoPreview=12024-03-31T11:00:00+00:001625.32Royal Society PublishingOceanic flows are turbulent and multi-scale in nature, and are composed of fast internal waves and slowly evolving balanced eddies. Contrary to conventional wisdom in physical oceanography, the past two decades of in situ, satellite altimeter and realistically forced global scale ocean model outputs have revealed that internal gravity waves can have comparable or higher energy levels than geostrophically balanced flows at 10–100 km scales in different parts of the world’s oceans. These relatively recent findings have fuelled a wide range of research activities aimed at understanding how fast internal gravity waves interact with slowly evolving balanced flows, particularly with the goal of deducing whether internal waves can form an energy sink for oceanic balanced flows. In this paper, we comprehensively review theoretical, numerical and observational investigations undertaken to study internal wave-balance flow exchanges. Theoretical calculations, inspired by different wave-balance regimes seen in observational and global ocean model outputs, are used to point out that internal waves can affect balanced flow dynamics. The theoretical results are followed up by a detailed discussion of numerical results on wave-balance interactions in a broad set of parameter regimes. The numerical results reveal how different kinds of waves exchange energy with balance flow, affect energy flux across scales of balanced flow and facilitate the generation of small-scale dissipative balanced flow structures. The numerical simulation results and global internal wave energy and balanced energy maps are used to conjecture that out of the 0.8 TW of power going to balanced flow kinetic energy in the ocean, at least 0.1 TW could be dissipated by internal gravity waves. We therefore hypothesize that internal waves can form a non-negligible energy sink for balanced flow in the world’s oceans.https://cassyni-user-files-prod.s3.amazonaws.com/A1yMeMRV9oynFgHA8oFNqU https://cassyni.com/events/ReuRuFrmqKandbzYuxqaub/seminar/qa https://cassyni.com/slides/outline/ReuRuFrmqKandbzYuxqaub https://cassyni.com/events/ReuRuFrmqKandbzYuxqaub/abstract https://cassyni-user-files-prod.s3.amazonaws.com/W5sokzf1ZaTmqr36NeZkuU https://cassyni.com/events/ReuRuFrmqKandbzYuxqaub?videoPreview=1 Diffraction of acoustic waves by edges and corners of a simple periodic materialnohttps://cassyni.com/events/ReuRuFrmqKandbzYuxqaub?videoPreview=12024-01-23T14:00:00+00:002745.08MetaMATIn diffraction theory, it is well known that the interfaces between two materials (points, lines or surfaces) play a fundamental role in wave scattering. In this talk I will explain the progress that is made into semi-analytical method to compute the wave scattering by a simple periodic material. The study of wave propagation in a periodic medium is a classical and important research direction but it is usually assumed that the material is infinite in all directions. The novelty of this approach is that the periodic material is semi-infinite and hence has edges and corners. In particular, I will consider semi-infinite arrays and wedges made of point scatters. The method will be a based on the generalisation of Wiener--Hopf techniques which has classically being used to solve scattering by one array. This is joint work with M. A. Nethercote and R. C. Assierhttps://cassyni-user-files-prod.s3.amazonaws.com/W5sokzf1ZaTmqr36NeZkuU https://cassyni.com/slides/outline/6Pcs6bdJiTyus1x3zfFHDP https://cassyni.com/events/6Pcs6bdJiTyus1x3zfFHDP/abstract https://cassyni-user-files-prod.s3.amazonaws.com/7e2hMThRDSLBnaVpQeqL14 https://cassyni.com/events/6Pcs6bdJiTyus1x3zfFHDP?videoPreview=1 Enduring, Intersectional Cancer Mortality Disparities in Persistent Poverty Countiesnohttps://cassyni.com/events/6Pcs6bdJiTyus1x3zfFHDP?videoPreview=12023-08-17T14:00:00+00:003111.44Center for Cancer TrainingCounties with higher levels of poverty since 1980 (“persistent poverty”) tend to be rural and racially diverse, but it is not clear how poverty, rurality, and race work together to influence trends in cancer mortality. We analyzed cancer deaths from 1990-1992 and 2014-2018. During each time period, compared to other counties, persistent poverty counties had about 12 excess cancer deaths per 100,000 people per year (1990-1992: 12.7, 95% confidence interval[CI]=11.4-14.1; 2014-2018: 11.0, 95% CI=10.2-11.8). Over time, disparities by persistent poverty widened for colorectal and breast cancers, but they were stable or mixed for the remaining cancer types. The highest mortality rates were observed among African American or Black residents of rural, persistent poverty counties for colorectal, oropharyngeal, breast, cervical, and prostate cancers. Since several factors influence cancer mortality, a multi-faceted approach is needed to improve outcomes in persistent poverty counties.https://cassyni-user-files-prod.s3.amazonaws.com/7e2hMThRDSLBnaVpQeqL14 https://cassyni.com/events/T8pdmA4KtStTvEhzBYHVF/seminar/qa https://cassyni.com/slides/outline/T8pdmA4KtStTvEhzBYHVF https://cassyni.com/events/T8pdmA4KtStTvEhzBYHVF/abstract https://cassyni-user-files-prod.s3.amazonaws.com/AJwXooYXAWGnMdaLXPh4Rc https://cassyni.com/events/T8pdmA4KtStTvEhzBYHVF?videoPreview=1 Introduction to the 4th Biometals webinars, Significance of chirality in siderophores: From marine microbes to pathogens, Perspectives on copper import in Streptococcus pneumoniaenohttps://cassyni.com/events/T8pdmA4KtStTvEhzBYHVF?videoPreview=12024-04-09T13:00:00+00:005303.64BioMetalsWelcome to the 4th international webinars series For those who don't already know, these webinars have been set up by the international Biometals society and the journal Biometals with the help of Cassyni platform. • The aim is to promote research in the field of metal interactions in biology and to encourage the interdisciplinary exchange of information at international level. Today we welcome two speakers: Alison Butler will be talking about Significance of chirality in siderophores: From marine microbes to pathogens. Fe is essential but may be scarce in some environment and its complexation and uptake require strong ferric iron chelators, siderophores that solubilize this “easily rusty ions”. Several hundreds of structures of siderophores have been described. I am sure Alison knows almost all of them! More than 99% of the dissolved iron in the ocean is bound to organic ligands, as complexation of iron to organic ligands can increase the solubility of iron by orders of magnitude and prevent precipitation and scavenging. Interestingly, marine microorganisms and pathogens develop some tricks for marine siderophores optimization and uptake and Alison will talk about that. The 2nd speaker, Michael Johnson will be talking about copper import in Streptococcus pneumoniae. Copper is also an essential element for biological life but as other it can be toxic when its homeostasis is uncontrolled. Starting from antiquity, copper has been used as a bactericidal agent. The demonstration of its efficiency as Cu metal to inhibit bacterial growth make it still useful in medical environment. In cellulo, copper ions are supposed to go from one protein partner to another to avoid its redox reactivity (as Fe) that can produce reactive oxygen species. Its uptake in all cells, prokaryotes as eukaryotes is under tight control but only few Cuprophores have been described. Today Michael will discuss copper homeostasis in the pathogen Streptococcus pneumonia. Specific types of microbial siderophores can be identified in microbial genomes based on characteristics of the Fe(III)-binding groups. We are particularly interested in chirality in siderophores, both within the siderophore ligand, as well as at the Fe(III) site. In the large class of peptidic siderophores, beta-hydroxyaspartate is often present as an Fe(III)-binding ligand. Biosynthesis of beta-hydroxyaspartate is intriguing in regards to the stereoselective control of hydroxylation catalyzed by non heme iron enzymes. The origin of the beta-hydroxyaspartate diastereomers in these siderophores is revealed in the microbial genomes. A new class of tris catechol siderophores in marine and pathogenic microbes is based on a variation of enterobactin, adding a combinatoric suite of D- and L- cationic amino acids. Variation in amino acid chirality directs stereochemistry at the Fe(III) site, which in turn profoundly affects microbial growth. While microbial genome mining encompasses microbes from all environments, marine microbes are found to be prominent in our investigations into the discovery, biosynthesis and reactivity of beta-hydroxyaspartate, and triscatecholate siderophores. These and further developments on the bioinorganic chemistry of siderophores containing beta-hydroxyaspartate, and catechol will be presented. Copper is broadly toxic to microbes at the host-pathogen interface. However, how copper gets into many bacteria has been a difficult question, considering they do not have dedicated copper importers. Somewhat complicating this analysis is that many of these organisms are studied in complex media containing an abundance of resources they would not normally encounter in the host or environment. In this talk, I will describe steps we have taken to use a minimal media for growing Streptococcus pneumoniae, a causative agent of multiple diseases including pneumonia, middle ear infections, and sepsis in the defined, minimal, and host-adjacent RPMI media, and how it led us to find that there was an iron-dependent increase in intrabacterial copper.https://cassyni-user-files-prod.s3.amazonaws.com/AJwXooYXAWGnMdaLXPh4Rc https://cassyni.com/events/GGax2GZoVd4EiXx5WE1eMK/seminar/qa https://cassyni.com/slides/outline/GGax2GZoVd4EiXx5WE1eMK https://cassyni.com/events/GGax2GZoVd4EiXx5WE1eMK/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Qu4xmpMzxGehcFgC7QGVuY https://cassyni.com/events/GGax2GZoVd4EiXx5WE1eMK?videoPreview=1 Targeting nanoplastic and microplastic in wastewaternohttps://cassyni.com/events/GGax2GZoVd4EiXx5WE1eMK?videoPreview=12024-02-01T13:00:00+00:002288.48Nature WaterWith growing concerns over plastic accumulation in the environment, it is imperative to quantify nanoplastic and microplastic release to water bodies via water treatment plant effluent streams. Current methodological limitations present a major challenge for continuous monitoring of nanosized pollutants in effluent streams. In this work, a novel correlation was established between removal of nanoplastics and total suspended solids (TSS) during aggregation-based wastewater treatment. The established correlation successfully predicted nanoplastic removal for a wide range of relevant nanoplastic properties, including polymer type, size, surface functionalization and ageing history, under 41 different physico-chemical and activated sludge treatment conditions (R2 = 0.92; n = 117). The results of our correlation reveal a predicted nanoplastic removal between 39% and 69% for typical water treatment effluent streams governed by current TSS regulations in North America. The study also reveals the potential of using TSS as a simple metric to estimate microfibre, microsphere and microfragment removal.https://cassyni-user-files-prod.s3.amazonaws.com/Qu4xmpMzxGehcFgC7QGVuY https://cassyni.com/slides/outline/AqTJWkT2fayAKfhquK1rMs https://cassyni.com/events/AqTJWkT2fayAKfhquK1rMs/abstract https://cassyni-user-files-prod.s3.amazonaws.com/8dKuSpzU6MSRomrGLq67NW https://cassyni.com/events/AqTJWkT2fayAKfhquK1rMs?videoPreview=1 Prospective Evaluation of PI-RADS Version 2.1 for Prostate Cancer Detection and Investigation of Multiparametric MRI-derived Markersnohttps://cassyni.com/events/AqTJWkT2fayAKfhquK1rMs?videoPreview=12024-02-15T19:00:00+00:002620.64Center for Cancer TrainingIn our study, we assessed the Prostate Imaging Reporting and Data System (PI-RADS), version 2.1, which is a continually developing and internationally acknowledged MRI-based scoring system used for evaluating the risk of prostate cancer. Conducted between April 2019 and December 2021, our prospective study focused on biological males with suspected or known prostate cancer, aiming to determine the effectiveness of PI-RADS 2.1 in conjunction with MRI features like lesion size, shape, and volume for detecting clinically significant prostate cancer. Apart from assessing the cancer yield in each PI-RADS category, another aspect of our work was to identify more objective, measurable criteria for lesion shape and volume, moving beyond the subjective parameters currently used in PI-RADS. We discovered that the likelihood of identifying clinically significant prostate cancer increases with higher PI-RADS categories and that quantifiable MRI features, such as lesion volume and measure of roundness, are predictors of significant cancer. Our findings also highlight that merging certain subcategories in PI-RADS might result in unnecessary biopsies. In conclusion, our research suggests that incorporating the objective lesion imaging criteria into patient care, alongside PI-RADS scores, could improve diagnostic accuracy. If validated in further studies, these objective measures could potentially be integrated into future iterations of PI-RADS, offering a more precise and reliable approach to prostate cancer detection and reducing unnecessary interventions.https://cassyni-user-files-prod.s3.amazonaws.com/8dKuSpzU6MSRomrGLq67NW https://cassyni.com/slides/outline/BL6uZS6Z73XDKSEjVkJedB https://cassyni.com/events/BL6uZS6Z73XDKSEjVkJedB/abstract https://cassyni-user-files-prod.s3.amazonaws.com/FwkcCZBnRJcxKXpWFFRhNW https://cassyni.com/events/BL6uZS6Z73XDKSEjVkJedB?videoPreview=1 Evolutionary constraints and imperfect ant mimicsnohttps://cassyni.com/events/BL6uZS6Z73XDKSEjVkJedB?videoPreview=12024-02-15T12:00:00+00:00565.12Royal Society PublishingAdaptive evolution relies on both heritable variation and selection. Variation is the raw material upon which selection acts, so any mechanism that limits or prevents the generation of heritable variation reduces the power of selection to lead to adaptation. Such limitations are termed evolutionary constraints. While it is widely accepted that constraints play an important role in shaping evolutionary outcomes, their relative importance, as opposed to adaptation, in determining evolutionary outcomes remains a subject of debate. Evolutionary constraints are often evoked as the reason behind the persistence of inaccurate mimicry. Here, we compared the variation and accuracy of body-shape mimicry in ant-mimicking spiders with that of ant-mimicking insects, predicting greater constraints, and hence inaccuracy, in spiders mimicking ants, due to their evolutionary distance from the ant model. We found high inter-species variation in mimetic accuracy, but dorsally, no overall difference in mimetic accuracy between spider and insect mimics, which is inconsistent with a constraint causing inaccurate mimicry. Our study provides empirical evidence suggesting that imperfect mimicry in spiders and insects is predominantly shaped by adaptive processes rather than constraints or chance. Our findings contribute to our understanding of the mechanisms underlying evolutionary diversity and the processes that shape phenotypic outcomes.https://cassyni-user-files-prod.s3.amazonaws.com/FwkcCZBnRJcxKXpWFFRhNW https://cassyni.com/slides/outline/JFCzKdfnepCixivi9kp2QV https://cassyni.com/events/JFCzKdfnepCixivi9kp2QV/abstract https://cassyni-user-files-prod.s3.amazonaws.com/P61J7PtvkLBsHDQ6Zaa3Ft https://cassyni.com/events/JFCzKdfnepCixivi9kp2QV?videoPreview=1 Functional Dyesnohttps://cassyni.com/events/JFCzKdfnepCixivi9kp2QV?videoPreview=12023-10-26T15:00:00+00:007060.84Thieme GroupFunctional dyes possess the ability to absorb light within the visible spectrum but are harnessed for their unique properties in their excited states, such as heat generation or light emission. Today, functional dyes represent a vibrant and evolving field of research, where scientists are continually exploring novel molecules capable of harnessing light energy for diverse functional applications.https://cassyni-user-files-prod.s3.amazonaws.com/P61J7PtvkLBsHDQ6Zaa3Ft https://cassyni.com/events/6tJ6FuniZHTjgUwZnmNFPb/abstract https://cassyni-user-files-prod.s3.amazonaws.com/UmH1joaswWAC7jjDYZeuEv https://cassyni.com/events/7NwhJbSEzk1ngFUTPCf3eu/abstract https://cassyni-user-files-prod.s3.amazonaws.com/8NtWx8J6a52849WhDzxQYv https://cassyni.com/slides/outline/EJ29xAVb99maB4U2keDyob https://cassyni.com/events/EJ29xAVb99maB4U2keDyob/abstract https://cassyni-user-files-prod.s3.amazonaws.com/DUoPw8R1hEjJkMcFt5ZD8z https://cassyni.com/events/EJ29xAVb99maB4U2keDyob?videoPreview=1 The heterogeneous impacts of widespread upzoning: Lessons from Auckland, New Zealandnohttps://cassyni.com/events/EJ29xAVb99maB4U2keDyob?videoPreview=12024-03-13T13:00:00+00:002188.28Business SchoolZoning reform is increasingly recognised as an important strategy to increase housing affordability and environmental sustainability. Few cities have undertaken significant upzoning of low-density neighbourhoods, making the 2016 Auckland Unitary Plan (AUP) probably the most ambitious zoning reform in the world. Parcels zoned for single houses previously dominated Auckland, but three-quarters of them now allow multiple units. Existing studies have documented the building boom that followed this zoning reform, yet the relatively rare case offers additional insights. In this article, we use appraisal, census and zoning data on over 200,000 parcels in Auckland to answer three research questions about the heterogeneous impacts of the AUP. First, to what extent did upzoning increase the appraised value of properties’ redevelopment options? Second, did upzoning increase appraised property values to a greater degree in higher-income and more centrally located neighbourhoods? Finally, was zoning reform in Auckland significantly influenced by similar political pressures as in other countries? That is, was upzoning less likely (and downzoning more likely) in higher-income neighbourhoods? The answers to these three questions are substantially, it’s complicated, and yes.https://cassyni-user-files-prod.s3.amazonaws.com/DUoPw8R1hEjJkMcFt5ZD8z https://cassyni.com/events/Bpn8ikFxws138uEFHrRcoP/abstract https://cassyni-user-files-prod.s3.amazonaws.com/R3Em3gfNdCeccviC8iBpw8 https://cassyni.com/slides/outline/QBTppYC9mSbFWPj3A2LXSu https://cassyni.com/events/QBTppYC9mSbFWPj3A2LXSu/abstract https://cassyni-user-files-prod.s3.amazonaws.com/TqADxUtHUXXXmyahdDWFBU https://cassyni.com/events/QBTppYC9mSbFWPj3A2LXSu?videoPreview=1 Global citizenship education: How can we assess it, and why should we?nohttps://cassyni.com/events/QBTppYC9mSbFWPj3A2LXSu?videoPreview=12024-02-28T16:00:00+00:002535.2Cassyni SeminarsThis webinar will explore how Global Citizenship Education (GCE) can be practically assessed and why that matters. I will present the key findings of my PhD thesis, which examined the integration of GCE into ELT textbooks used in UAE secondary schools. This includes the adaptation of GCE to autocratic contexts and the design of a framework to develop and assess GCE. I will then demonstrate how I have embedded that framework into a portfolio platform for youth citizenship, Citizens, which I founded at the completion of my PhD and which has received Innovate UK funding to codesign with teenagers and prototype.https://cassyni-user-files-prod.s3.amazonaws.com/TqADxUtHUXXXmyahdDWFBU https://cassyni.com/events/KEynMhiuNs4E7J1h9YdXim/seminar/qa https://cassyni.com/slides/outline/KEynMhiuNs4E7J1h9YdXim https://cassyni.com/events/KEynMhiuNs4E7J1h9YdXim/abstract https://cassyni-user-files-prod.s3.amazonaws.com/6okvquiaJLNmyVm9VzS83x https://cassyni.com/events/KEynMhiuNs4E7J1h9YdXim?videoPreview=1 Cold adaptation does not handicap warm tolerance in the most abundant Arctic seabirdnohttps://cassyni.com/events/KEynMhiuNs4E7J1h9YdXim?videoPreview=12024-05-02T08:00:00+00:003527.72Royal Society PublishingArctic birds and mammals are physiologically adapted to survive in cold environments but live in the fastest warming region on the planet. They should therefore be most threatened by climate change. We fitted a phylogenetic model of upper critical temperature (TUC) in 255 bird species and determined that TUC for dovekies (Alle alle; 22.4°C)—the most abundant seabird in the Arctic—is 8.8°C lower than predicted for a bird of its body mass (150 g) and habitat latitude. We combined our comparative analysis with in situ physiological measurements on 36 dovekies from East Greenland and forward-projections of dovekie energy and water expenditure under different climate scenarios. Based on our analyses, we demonstrate that cold adaptation in this small Arctic seabird does not handicap acute tolerance to air temperatures up to at least 15°C above their current maximum. We predict that climate warming will reduce the energetic costs of thermoregulation for dovekies, but their capacity to cope with rising temperatures will be constrained by water intake and salt balance. Dovekies evolved 15 million years ago, and their thermoregulatory physiology might also reflect adaptation to a wide range of palaeoclimates, both substantially warmer and colder than the present day.https://cassyni-user-files-prod.s3.amazonaws.com/6okvquiaJLNmyVm9VzS83x https://cassyni.com/events/VcbUL4JvbUgedoJqAeaRQH/seminar/qa https://cassyni.com/slides/outline/VcbUL4JvbUgedoJqAeaRQH https://cassyni.com/events/VcbUL4JvbUgedoJqAeaRQH/abstract https://cassyni-user-files-prod.s3.amazonaws.com/PgssBHYVYsu4n4Wrt3YEAi https://cassyni.com/events/VcbUL4JvbUgedoJqAeaRQH?videoPreview=1 The Buddhist Sengzhao’s Roots in Daoism: Ex Contradictione Nihilnohttps://cassyni.com/events/VcbUL4JvbUgedoJqAeaRQH?videoPreview=12024-05-15T14:00:00+00:005125.04Logica UniversalisSengzhao (c.374–414) was a Chinese Neo-Daoist who converted to Mahāyāna Buddhism, and few people doubt his influence on Chinese Buddhist philosophy. In this article, provided his Neo-Daoism (*xuanxue*) and Madhyamaka Buddhism, I will present how Sengzhao featured a symbolic meaning of ‘void’ (*śūnya*) as rooted originally in Daoism. The Daoist contradictions, in particular between ‘being’ (*you*) and ‘nothing [non-being]’ (*wu*), are essential to the development of his doctrine of ‘no ultimate void’ (不真空論, *Buzhenkonglun*). To understand what Sengzhao meant by ‘void’, which is in denial about the ultimate reality, I broach a notion of *nihil* (‘nothing’ but also ‘no value’) that bears on his discursive practice. In this light, I formulate a Daoist argument for contradictions and ECN (*ex contradictione nihil* – nothing follows from contradictions) from Laozi’s *Daodejing*. Furthermore, I elaborate on Sengzhao’s defence of ECN in his *Buzhenkonglun*. Reconstructing his negative approach to contradictions within the scope of the four-valued expressions (*catuṣkoṭi*) in the Madhyamaka tradition from Nāgārjuna, I consider a likely objection that a fifth value such as the ineffable may be inferred as void. Instead of subsuming the ineffable value under his discourse, I finally endorse Sengzhao’s purpose of linguistic and conventional approximation of the ultimate reality as silence. As such, I conclude the significance of void in Sengzhao’s denials via contradictions (ECN), i.e. an early philosophical peak of Chinese Buddhism from Daoism.https://cassyni-user-files-prod.s3.amazonaws.com/PgssBHYVYsu4n4Wrt3YEAi https://cassyni.com/events/SA4F1GnFXGp1c71GWzCTsT/abstract https://cassyni-user-files-prod.s3.amazonaws.com/ARNQFB8vutZ3rgDJ7wmiWA https://cassyni.com/events/UdJGEh1siZaVy3Uq4g76bP/seminar/qa https://cassyni.com/slides/outline/UdJGEh1siZaVy3Uq4g76bP https://cassyni.com/events/UdJGEh1siZaVy3Uq4g76bP/abstract https://cassyni-user-files-prod.s3.amazonaws.com/T81oxr1YyfZdAwaasy6ppN https://cassyni.com/events/UdJGEh1siZaVy3Uq4g76bP?videoPreview=1 Saami in education: Translanguaging and Spaces for Saami language usenohttps://cassyni.com/events/UdJGEh1siZaVy3Uq4g76bP?videoPreview=12024-06-26T04:10:00+00:003720.28Linguistics and Applied Language StudiesThis session consists of two talks: One by David Kroik and the other by Maajja-Krihke Bransfjell. The abstracts are provided below in that order: South Saami language revitalisation, Indigenous efflorescence and Spaces for Saami language use In this talk, the construction of spaces for Saami language use is explored. In these spaces, learning and use of South Saami is at the centre. This dissertation in language teaching and learning focusses on the South Saami language, an Indigenous language in the parts of Saepmie that overlaps with Norway and Sweden. Against the backdrop of colonisation of the Saami and a long trend of assimilation by means of e.g. schooling, focus lies on contemporary spaces for Saami language use in formal educational contexts. Spaces for Saami language use are investigated and theorised upon from an insider position by a researcher/practitioner drawing upon a collaborative approach to the production of knowledge. The insider gaze through the lens of the theoretical concept of spaces for Saami language use and Indigenous efflorescence analyses South Saami language teaching, learning and revitalisation as part of a global trend in which Indigenous peoples reclaim, revitalise and restore their continuous use of land, space and language. The author investigates opportunities for and obstacles to furthering the development of spaces for Saami language use. How Saami practitioners of Indigenous efflorescence, for instance teachers, coordinators, artists and others commit to the language is brought to the fore. By means of their acts of decoloniality, they seek to take responsibility for and challenge the current educational situation. Spaces for Saami language use emerge as time and conditions ripen for them. Although unexpected to many, given the history of assimilation, to the practitioners of efflorescence involved in the process, this emergence comes not as a surprise but as a hard-earned result of the struggle. Although much work remains, hope is reawakened when conscious hard work and persistent labour bear fruit. «Edtjebe saemiestidh daelie?» [Are we supposed to speak Saami now?]: language spaces, language awareness and the use of language in a south-saami classroom Abstract Recent public reports proclaim that Saami children should be provided with education that facilitate their productive Saami language skills (NOU 2016:18, 2016; Pasanen et al., 2022, s. 13). Despite these reports and research suggesting that language education should be executed using strong language models (Baker & Wright, 2017) in order to achieve Saami language proficiency, Saami language education is restricted to a few hours weekly, using weak language models. With inspiration from the language revitalization project in Svahken Sijte (Todal, 2007) and Árran mánájgárdde in Lule-Saami area (Pasanen et al., 2022), I implemented Norwegian language spaces in a Saami classroom to encourage students to speak Saami in class. I let the bilingual concept translanguaging (Baker & Wright, 2017; García et al., 2016) guide my work together with the teacher in the Saami classroom, in which students were able to utilize their whole language repertoire. By means of classroom observations and interviews with the teacher and group interviews with the students, I evaluated the effect of the language spaces. By utilizing Norwegian language spaces in Saami language education, my analyses show an increased awareness around the use of Saami language in the classroom among teacher and students alike. The language spaces acted as a language frame in the classroom, in which the concretization of the languages contributed to an increased use of Saami language among the students. Based on this research I claim that language spaces can contribute to increased Saami language proficiency within children. References: Baker, C. & Wright, W. E. (2017). Foundations of bilingual education and bilingualism (6. utg.). Multilingual Matters. García, O., Ibarra Johnson, S. & Seltzer, K. (2016). The Translanguaging Classroom: Leveraging Student Bilingualism for Learning. Brookes Publishing. NOU 2016:18. (2016). Hjertespråket: forslag til lovverk, tiltak og ordninger for samiske språk (978-82-583-1293-9). K.-o. moderniseringsdepartementet. Departementenes sikkerhets- og serviceorganisasjon, Informasjonsforvaltning. https://www.regjeringen.no/contentassets/ad82d773c3094582a2660908b48886d3/no/pdfs/nou201620160018000dddpdfs.pdf Pasanen, A., Päiviö, Á.-M., Baal, B. A. B. & Mikkelsen, I. L. S. (2022). Sterke språkmodeller. Sámediggi. Todal, J. (2007). Samisk språk i Svahken Sijte: Sørsamisk vitalisering gjennom barnehage og skule. Sámi allaskuvla / Sámi University of Applied Sciences. https://cassyni-user-files-prod.s3.amazonaws.com/T81oxr1YyfZdAwaasy6ppN https://cassyni.com/events/5Qps4ZcD63YkU7YzEsH7yw/seminar/qa https://cassyni.com/slides/outline/5Qps4ZcD63YkU7YzEsH7yw https://cassyni.com/events/5Qps4ZcD63YkU7YzEsH7yw/abstract https://cassyni-user-files-prod.s3.amazonaws.com/TVhCzNcVKxa7HeRcuhBgHt https://cassyni.com/events/5Qps4ZcD63YkU7YzEsH7yw?videoPreview=1 Aerodynamic Optimisation of Aerofoils for Martian Rotorcraft Using Direct Numerical Simulationsnohttps://cassyni.com/events/5Qps4ZcD63YkU7YzEsH7yw?videoPreview=12024-10-07T16:00:00+00:003470.92AIAA JournalThroughout the last century, designers have worked to optimize aerofoils for a wide range of terrestrial conditions. However, Martian atmospheric density is less than 1% of that on Earth, and Martian surface temperature and atmospheric composition lead to a lower sound speed. Consequently, rotors for a Martian helicopter – such as Ingenuity which flew on Mars in 2021 – must operate in a low Reynolds number compressible regime that is seldom encountered on Earth. Non-conventional aerofoils with sharp edges and flat surfaces have shown improved performance under such conditions, and second-order-accurate Reynolds-averaged Navier-Stokes (RANS) and Unsteady RANS (URANS) solvers have been combined with genetic algorithms to optimise them. However, flow over such aerofoils is characterised by unsteady roll-up of coherent vortices that subsequently break down/transition. Accordingly, RANS/URANS solvers have limited predictive capability, especially at higher angles of attack where the aforementioned physics are more acute. In this seminar I will present recent efforts to overcome this limitation via use of high-order GPU-accelerated Direct Numerical Simulations (DNSs).https://cassyni-user-files-prod.s3.amazonaws.com/TVhCzNcVKxa7HeRcuhBgHt https://cassyni.com/slides/outline/7t4tHyqqHLKEq42YnZBkhs https://cassyni.com/events/7t4tHyqqHLKEq42YnZBkhs/abstract https://cassyni-user-files-prod.s3.amazonaws.com/JFYgweMoTWwWxvFmrW3Ptz https://cassyni.com/events/7t4tHyqqHLKEq42YnZBkhs?videoPreview=1 2024 ORCID Community Town Hallnohttps://cassyni.com/events/7t4tHyqqHLKEq42YnZBkhs?videoPreview=12024-03-20T18:00:00+00:003625.48ORCID EventsWe are delighted to invite you to attend the ORCID Community Town Hall meeting on March 20, 2024. To accommodate our global audience, we’ve organized two separate instances of the event. ORCID Community Town Hall Webinar on March 20 at 01:00 UTC (best for those located in APAC; see your time zone here) ORCID Community Town Hall Webinar on March 20 at 15:00 UTC (best for those located in EMEA and the Americas; see your time zone here) The ORCID senior team will share the progress we made in 2023 and give a special preview of our plans for 2024. As always, there will be plenty of opportunity for you to engage with us: to provide feedback, make suggestions, and ask questions.https://cassyni-user-files-prod.s3.amazonaws.com/JFYgweMoTWwWxvFmrW3Ptz https://cassyni.com/events/4RXeyCKAD8SboMiz8tooB3/seminar/qa https://cassyni.com/slides/outline/4RXeyCKAD8SboMiz8tooB3 https://cassyni.com/events/4RXeyCKAD8SboMiz8tooB3/abstract https://cassyni-user-files-prod.s3.amazonaws.com/AxF3xAo3PrDfjQv7HoFZmQ https://cassyni.com/events/4RXeyCKAD8SboMiz8tooB3?videoPreview=1 The Polymer Surfactant Aggregate Process For The Selective Recovery Of Valuable Metallic Species From Aqueous Effluent Streamsnohttps://cassyni.com/events/4RXeyCKAD8SboMiz8tooB3?videoPreview=12024-11-12T10:00:00+00:005165.04ElsevierAcidic copper mine wastewaters often contain significant amounts of Cu and Fe ions. Because of the challenging solution conditions (such as low pH), selective recovery of the Cu is usually limited for conventional technologies, such as ion exchange. The novel polymer surfactant aggregate (PSA) process, developed in previous studies (1), uses functionalized hydrophilic polymers in solution to achieve selective chelation of the target metallic ion. Surfactant aggregates then adsorb on to the chains to facilitate charge neutralisation, causing flocculation and settling, thus selectively removing the target. In this study, the functionalized polymer picolyl-polyethylenimine (PPEI) was synthesized and applied with an anionic surfactant (SDS) for Cu (II) selective recovery from Fe (III) in acidic aqueous streams. Performance was compared with conventional ion exchange resins, including functionalized silica. The PSA process based on functionalized PPE polymer shows a high selectivity of Cu over Fe at low pH values, removing in a short time up to 90% of 100 mg/L Cu from a mixture with 500 mg/L Fe. The talk will also discuss the selective recovery of palladium from tin, and the recovery of platinum group metals. The selective removal performance of the PSA process is superior to established ion exchange processes. It is achieved in minutes of contact rather than hours, and uses a simple, inexpensive flocculation process within a homogeneous aqueous phase and without the need for complex contacting equipment. https://cassyni-user-files-prod.s3.amazonaws.com/AxF3xAo3PrDfjQv7HoFZmQ https://cassyni.com/slides/outline/Eo9LwYuBRk52Ks289zkgrZ https://cassyni.com/events/Eo9LwYuBRk52Ks289zkgrZ/abstract https://cassyni-user-files-prod.s3.amazonaws.com/VLvwXQL9ub7UDjcFLX9grA https://cassyni.com/events/Eo9LwYuBRk52Ks289zkgrZ?videoPreview=1 Interpretable Aeroelastic Models for Control at Insect Scalenohttps://cassyni.com/events/Eo9LwYuBRk52Ks289zkgrZ?videoPreview=12022-09-29T14:00:00+00:001013.32Brunton LabIn this video, Michelle Hickner describes a data-driven modeling technique for aeroelastic systems and demonstrates how the interpretable model can aid in controller design.https://cassyni-user-files-prod.s3.amazonaws.com/VLvwXQL9ub7UDjcFLX9grA https://cassyni.com/events/Qg93yrMZcG55KriYx8TVd7/seminar/qa https://cassyni.com/slides/outline/Qg93yrMZcG55KriYx8TVd7 https://cassyni.com/events/Qg93yrMZcG55KriYx8TVd7/abstract https://cassyni-user-files-prod.s3.amazonaws.com/St2H3jJgv6Y5b38SzpwXtS https://cassyni.com/events/Qg93yrMZcG55KriYx8TVd7?videoPreview=1 Greening aviation: Is evidence-based policymaking possible?nohttps://cassyni.com/events/Qg93yrMZcG55KriYx8TVd7?videoPreview=12024-06-27T13:00:00+00:003450.08Brahmal Vasudevan Institute for Sustainable AviationAircraft are a significant and growing source of air and climate pollution. As a hard-to-abate sector, there are real technological, economic, and operational barriers to decarbonizing aviation. But effective regulation is also constrained by political forces, namely extreme industry concentration, international bureaucracy, protectionism, and international development politics. In this seminar, Dan Rutherford from the International Council on Clean Transportation draws on concrete examples from over 15 years of policy work to explore the promise and limits of evidence-based policymaking as the aviation industry takes its first steps toward net-zero flight.https://cassyni-user-files-prod.s3.amazonaws.com/St2H3jJgv6Y5b38SzpwXtS https://cassyni.com/events/HGQzHbeh2PmZZpXePxqsB3/seminar/qa https://cassyni.com/slides/outline/HGQzHbeh2PmZZpXePxqsB3 https://cassyni.com/events/HGQzHbeh2PmZZpXePxqsB3/abstract https://cassyni-user-files-prod.s3.amazonaws.com/P25qZjKfHVC5hR4RiWFJ1U https://cassyni.com/events/HGQzHbeh2PmZZpXePxqsB3?videoPreview=1 Age-Friendly Health System Transformation: Insights for Family Medicine from Implementation of the 4Msnohttps://cassyni.com/events/HGQzHbeh2PmZZpXePxqsB3?videoPreview=12024-08-22T20:00:00+00:003158.68Family MedicineLearning Objectives: - Describe what it means to be "age-friendly" - Discuss barriers, facilitators, and outcomes of Age-Friendly Health System implementation, using an implementation science framework - Reflect on opportunities for 4Ms integration into family medicine traininghttps://cassyni-user-files-prod.s3.amazonaws.com/P25qZjKfHVC5hR4RiWFJ1U https://cassyni.com/events/CKvwpmBSdpEG7QExtsnVmF/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Jwzyp8og7YT8xPKZ2vFWBg https://cassyni.com/slides/outline/FHnwzEYhsCd5KdZ1kS3V7s https://cassyni.com/events/FHnwzEYhsCd5KdZ1kS3V7s/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Qym1zWDvQe8we5xUgJGRYr https://cassyni.com/events/FHnwzEYhsCd5KdZ1kS3V7s?videoPreview=1 Exploiting Geometric Structure in Machine Learning and Optimizationnohttps://cassyni.com/events/FHnwzEYhsCd5KdZ1kS3V7s?videoPreview=12022-11-04T14:00:00+00:004556.32AI Institute in Dynamic SystemsMotivated by the observation that many applications involve non-Euclidean data, such as graphs, strings, or matrices, we discuss how Riemannian geometry can be exploited in Machine Learning and Optimization. First, we discuss the problem of characterizing data geometry from the perspective of Discrete Geometry, specifically focusing on the analysis of relational data. Secondly, we discuss examples of exploiting geometry in downstream tasks. We begin by considering the task of learning a classifier in hyperbolic spaces. Such spaces have received a surge of interest for representing large-scale, hierarchical data, since they achieve better representation accuracy with fewer dimensions. Next, we consider the problem of optimizing a function on a Riemannian manifold. Specifically, we will consider classes of optimization problems where exploiting Riemannian geometry can deliver algorithms that are computationally superior to standard (Euclidean) approaches.https://cassyni-user-files-prod.s3.amazonaws.com/Qym1zWDvQe8we5xUgJGRYr https://cassyni.com/slides/outline/9rfJUiRw3AXzvmJn9X3h8R https://cassyni.com/events/9rfJUiRw3AXzvmJn9X3h8R/abstract https://cassyni-user-files-prod.s3.amazonaws.com/ThKqkGHJpfBXWjqpPrf3pr https://cassyni.com/events/9rfJUiRw3AXzvmJn9X3h8R?videoPreview=1 Dynamical systems and machine learning: combining in a principled way data-driven models and domain-driven modelsnohttps://cassyni.com/events/9rfJUiRw3AXzvmJn9X3h8R?videoPreview=12020-10-16T14:00:00+00:004186.44AI Institute in Dynamic SystemsNo abstracthttps://cassyni-user-files-prod.s3.amazonaws.com/ThKqkGHJpfBXWjqpPrf3pr https://cassyni.com/slides/outline/NCu2kS7wQyJaxvEzQSYruB https://cassyni.com/events/NCu2kS7wQyJaxvEzQSYruB/abstract https://cassyni-user-files-prod.s3.amazonaws.com/AL8qLaQFBAJTZQU75bMKk https://cassyni.com/events/NCu2kS7wQyJaxvEzQSYruB?videoPreview=1 Unraveling the role of KNOTTED OF BRACHYPODIUM 7 in grass-specific cell wall developmentnohttps://cassyni.com/events/NCu2kS7wQyJaxvEzQSYruB?videoPreview=12024-06-07T14:00:00+00:00918.2New Phytologist Foundation The synthesis and deposition of cellulose, hemicellulose, and lignin in xylem and fiber cells is a key aspect of plant growth. KNOTTED-LIKE HOMEOBOX OF ARABIDOPSIS THALIANA 7 (KNAT7) is a transcriptional repressor of secondary cell wall thickening. A rabidopsis thaliana mutants have thicker interfascicular fiber walls and more lignin. Mutants of the closest rice ortholog show thicker interfascicular fiber walls, but without a reported change in lignin content. To further investigation the function of this genes in regulating secondary cell wall synthesis in grasses, mutant and overexpression lines of the Brachypodium distachyon KNAT7 ortholog, KNOTTED OF BRACHYPODIUM 7 (KNOB7) were generated. Stem interfascicular fiber wall thickness increased in the mutants and decreased in KNOB7 overexpressing plants. A similar trend was observed in the mutant related to the lignin composition, hydroxycinnamic acids and cell wall polysaccharide content. DNA affinity purification sequencing revealed 3,228 binding sites. Target genes were significantly enriched for phenylpropanoid pathway genes. The DNA target sequence of KNOB7 protein was a W-box like sequence, TTGAC. Our findings reveal that KNOB7 interacts with the W-box element to repress lignin biosynthesis and wall thickening.https://cassyni-user-files-prod.s3.amazonaws.com/AL8qLaQFBAJTZQU75bMKk https://cassyni.com/slides/outline/RApH9AWyT5ZDss3d9wpZmF https://cassyni.com/events/RApH9AWyT5ZDss3d9wpZmF/abstract https://cassyni-user-files-prod.s3.amazonaws.com/3q1oLxgHb8oy2X5QVr9B3t https://cassyni.com/events/RApH9AWyT5ZDss3d9wpZmF?videoPreview=1 Navigating Challenges in Peer Review: Perspectives from University Presses and Associationsnohttps://cassyni.com/events/RApH9AWyT5ZDss3d9wpZmF?videoPreview=12024-09-24T18:00:00+00:003672.32ORCIDJoin us on 24 September for a dynamic and insightful webinar featuring perspectives from universities, university presses, associations, and peer reviewers. This session will delve into the complexities and evolving landscape of peer review in scholarly publishing. Peer review is a cornerstone of academic integrity, but it comes with its own set of challenges, including reviewer selection, maintaining impartiality, and managing reviewer workloads. Our distinguished panel will share their experiences and strategies for overcoming these obstacles, ensuring high-quality and unbiased reviews. Topics to be covered include: - Current Trends, Challenges, and Innovations: Explore how different communities are adapting to the changing dynamics of peer review. - Impacts and Developments: Understand the effects of the Public Access ("Nelson") Memo in the US and Open Access (OA) mandate compliance. - Maintaining Quality and Integrity: Learn best practices for upholding rigorous standards while managing increasing submission volumes. - Technology and Tools: Discover the role of digital solutions, including ORCID, in streamlining the peer review process and the potential impact of AI. - Collaborative Community Review: Examine the possibilities that collaboration presents for creating value-driven review and publishing workflows.https://cassyni-user-files-prod.s3.amazonaws.com/3q1oLxgHb8oy2X5QVr9B3t https://cassyni.com/slides/outline/3SHh763t8wBp57mLmrRu4q https://cassyni.com/events/3SHh763t8wBp57mLmrRu4q/abstract https://cassyni-user-files-prod.s3.amazonaws.com/BTVU3WsUEsjoqbTXXUgS1L https://cassyni.com/events/3SHh763t8wBp57mLmrRu4q?videoPreview=1 Urinary microbiome resistance: urinary lactobacilli inhibit three major uropathogens in vitronohttps://cassyni.com/events/3SHh763t8wBp57mLmrRu4q?videoPreview=12022-04-12T15:00:00+00:00672.0Microbiome Virtual International Forum The human urinary microbiome is thought to affect the development and progression of urinary tract infections (UTI), particularly recurrent UTIs in aging women. To understand the possible interactions of urinary pathogens with commensal bacteria inhabiting the aging bladder, we conducted an initial functional assessment of a representative set of urinary lactobacilli that dominate this niche in pre- and postmenopausal women. We created a repository of urinary bladder bacteria isolated via Enhanced Quantitative Urinary Culture (EQUC) from healthy postmenopausal women, as well as those with culture-proven recurrent UTI diagnosis. This repository contains lactobacilli strains from eight different species. As many other lactobacilli are known to inhibit human pathogens, including typical uropathogens, we screened the urinary lactobacilli in our repository for their ability to inhibit model uropathogens in vitro. We observed that many urinary lactobacilli strongly inhibit model gram-negative pathogens Escherichia coli and Klebsiella pneumoniae but demonstrate less inhibition of gram-positive pathogen Enterococcus faecalis. The observed inhibition is not specific to these model uropathogens and also affects clinical and multidrug-resistant isolates. Our preliminary analysis of inhibition mechanisms implicates pH as an important factor with additional cell-dependent inhibition mechanisms that differ amongst species and strains of urinary lactobacilli. Overall, our data show that urinary lactobacilli are broadly inhibiting uropathogen growth in vitro via a combination of different mechanisms. Nevertheless, simple measured inhibition level is not predictive of health outcomes in colonized patients, and species and strain level diversity of urinary lactobacilli is high.https://cassyni-user-files-prod.s3.amazonaws.com/BTVU3WsUEsjoqbTXXUgS1L https://cassyni.com/slides/outline/AMN9kf7EHLwbZvkv9HzqDX https://cassyni.com/events/AMN9kf7EHLwbZvkv9HzqDX/abstract https://cassyni-user-files-prod.s3.amazonaws.com/M678LDUKPwbctYX577zbSe https://cassyni.com/events/AMN9kf7EHLwbZvkv9HzqDX?videoPreview=1 A Resource of Microbiome Benchmark Datasets with Biological Ground Truthnohttps://cassyni.com/events/AMN9kf7EHLwbZvkv9HzqDX?videoPreview=12022-11-08T11:00:00+00:0058.8Microbiome Virtual International Forum Little consensus exists about which statistical methods are most suitable for identifying differentially abundant (DA) taxa in microbiome research. A limitation of benchmarking DA methods is the lack of datasets with ground truth. Here, we introduce the MicrobiomeBenchmarkData package/resource of datasets with known biological ground truth and varying ecological complexity. We compiled and standardized three datasets: 1) a high-diversity dataset from the Human Microbiome Project contrasting subgingival and supragingival oral plaques using both 16S and shotgun data, 2) a low-diversity 16S dataset of healthy vaginal and bacterial vaginosis samples, and 3) a 16S spike-in dataset containing fixed amounts of foreign spiked-in bacteria across stool samples of patients who underwent allogeneic stem transplantation. We used the first two datasets to benchmark 17 differential abundance methods broadly categorized as classical, compositional, microbiome-specific, RNA-seq, and scRNA-seq tests. We used the third dataset to assess low variability of spiked-in bacteria. Overall, RNAseq methods performed best in the high-diversity dataset (gingiva) while most methods performed well in the low-diversity dataset (vagina). Notably, compositional methods proposed specifically for microbiome data analysis, performed equivalently to other methods in the high-complexity dataset but produced spurious results in the low-diversity dataset and increased unwanted variability of spike-in bacteria. The MicrobiomeBenchmarkData project aims to be a gold-standard resource of microbiome datasets for benchmarking DA methods based on biologically relevant signatures, following the data FAIRness principles of Findability, Accessibility, Interoperability, and Reusability. Datasets are available as TSV text files through Zenodo (https://doi.org/10.5281/zenodo.6911026), and as TreeSummarizedExperiment class objects through the MicrobiomeBenchmarkData R/Bioconductor package (https://waldronlab.io/MicrobiomeBenchmarkData).https://cassyni-user-files-prod.s3.amazonaws.com/M678LDUKPwbctYX577zbSe https://cassyni.com/slides/outline/MDf4tKrfLn3oEgHM3QAxny https://cassyni.com/events/MDf4tKrfLn3oEgHM3QAxny/abstract https://cassyni-user-files-prod.s3.amazonaws.com/8WDZPEVEQVH9wwhapVZaGv https://cassyni.com/events/MDf4tKrfLn3oEgHM3QAxny?videoPreview=1 Comprehensive analyses of a large human gut Bacteroidales culture collection reveal species and strain level diversity and evolutionnohttps://cassyni.com/events/MDf4tKrfLn3oEgHM3QAxny?videoPreview=12024-04-17T12:00:00+00:00614.04Microbiome Virtual International Forum Species of the Bacteroidales order are among the most abundant and stable bacterial members of the human gut microbiome with diverse impacts on human health. While Bacteroidales strains and species are genomically and functionally diverse, order-wide comparative analyses are lacking. We cultured and sequenced the genomes of 408 Bacteroidales isolates from healthy human donors representing nine genera and 35 species and performed comparative genomic, gene-specific, mobile gene, and metabolomic analyses. Families, genera, and species could be grouped based on many distinctive features. However, we also show extensive DNA transfer between diverse families, allowing for shared traits and strain evolution. Inter- and intra-specific diversity is also apparent in the metabolomic profiling studies. This highly characterized and diverse Bacteroidales culture collection with strain-resolved genomic and metabolomic analyses can serve as a resource to facilitate informed selection of strains for microbiome reconstitution.https://cassyni-user-files-prod.s3.amazonaws.com/8WDZPEVEQVH9wwhapVZaGv https://cassyni.com/slides/outline/Pgu67k6HY4pHbckub65bWu https://cassyni.com/events/Pgu67k6HY4pHbckub65bWu/abstract https://cassyni-user-files-prod.s3.amazonaws.com/FXWEJbmv2aBts72rQqLUjx https://cassyni.com/events/Pgu67k6HY4pHbckub65bWu?videoPreview=1 Microbiome Science for Everyone: MVIF season 1&2nohttps://cassyni.com/events/Pgu67k6HY4pHbckub65bWu?videoPreview=12023-09-19T13:00:00+00:0057.04Microbiome Virtual International Forum The Microbiome Virtual International Forum (MVIF) is a substitute for multi-day microbiome conferences. MVIF was created by microbiome scientists with intent to be free, beneficial, and convenient for scientists all over the world, no matter their career stage. The MVIF creators are hoping to make the event as productive as possible. Therefore, in this NSURP2023 project (https://nsurp.org/), my aim was to compare MVIF Season 1 and MVIF Season 2 by compiling speakers’ information from https://www.microbiome-vif.org/en-US/-/past-events and documenting it in a Google Sheet. I hypothesized that there would be a few differences between the seasons in some aspects of the past MVIF events. The speakers’ metadata was analyzed using Python libraires: pandas, numpy and matplotlib. The results showed that there were a total of 142 speakers with 53% being females and the remaining 47% being males. For both seasons, most of the speakers’ affiliated locations were the USA and European countries and their talks focused on the human gut and bioinformatics. I was able to see a difference between the two seasons: Season 1 had a total of 82 speakers (with consequently a higher number of talks) whereas Season 2 had 60 speakers. Although season 1 had more diverse microbiome topics, in Season 2 there’s a slight increase in non-human microbiome topics, such as water microbiome. From September, there will be a new season with an effort to amplify more diverse voices of microbiome science.https://cassyni-user-files-prod.s3.amazonaws.com/FXWEJbmv2aBts72rQqLUjx https://cassyni.com/slides/outline/LEMrnxZcTrweZvTLwRhdz5 https://cassyni.com/events/LEMrnxZcTrweZvTLwRhdz5/abstract https://cassyni-user-files-prod.s3.amazonaws.com/TsYbmuriarU2W8HTbv6Npn https://cassyni.com/events/LEMrnxZcTrweZvTLwRhdz5?videoPreview=1 The Human Microbiome in Precision Medicinenohttps://cassyni.com/events/LEMrnxZcTrweZvTLwRhdz5?videoPreview=12023-12-19T10:00:00+00:002433.0Microbiome Virtual International Forum The human microbiome is a high dimensional and dynamic part of our physiology that plays a key role in managing health and individualized responses to diet and medicine. The immune system controls our interaction with the microbial world, and the microbial communities in our bodies are central to modulating the immune response. Changes in the human microbiome and their metabolism have substantial influence on atopy, neurological disorders, metabolic disorders, and a range of complex conditions and disease states. Diet is incredibly important in shaping human health and the microbiome, altering both composition and metabolic activity, resulting in changes in immune, endocrine, and neurological systems. Microbiome-Wide Association Studies (MWAS) combined with novel quantitative multi-omic approaches are enabling us to use AI techniques to determine personalized responses to nutrition that drive diseases states and treatment efficacy. Through these innovations, we are finally realizing the paradigm of precision medicine for facilitating patient care.https://cassyni-user-files-prod.s3.amazonaws.com/TsYbmuriarU2W8HTbv6Npn https://cassyni.com/slides/outline/WbyYmK9dgUa56RkUxXeXfb https://cassyni.com/events/WbyYmK9dgUa56RkUxXeXfb/abstract https://cassyni-user-files-prod.s3.amazonaws.com/oCSu3MSvAHfCmzB7yPRRY https://cassyni.com/events/WbyYmK9dgUa56RkUxXeXfb?videoPreview=1 Mapping the functionality of the microbiome using metabolic phenotypingnohttps://cassyni.com/events/WbyYmK9dgUa56RkUxXeXfb?videoPreview=12023-04-19T10:00:00+00:002228.04Microbiome Virtual International Forum The contribution of the gut microbiota to human health and disease is undisputed, yet the mechanisms by which the microbiome exerts its effects remain poorly understood. Co-evolution of host and microbiome has influenced the functionality of both the microbiome and host such that metabolic complementarity exists within the microbiota and that critical biosynthetic pathways are provided for the host that significantly extend host metabolic capacity. Of all the ‘omics’ technologies, metabonomics provides one of the most accessible windows on investigating the impact of the microbiome on human health since metabolic profiles of easily obtainable biofluids such as blood plasma and urine carry information relating both to genetic and environmental influences, including microbiome-diet and microbiome-xenobiotic interactions. High resolution spectroscopy together with multivariate mathematical modelling has been used to model the metabolic consequences of perturbing the microbiota and to profile the effects of nutritional interventions on both the metabolism and the microbiome. Basic studies in germ free and antibiotic-treated animals have shown stark changes in the urinary and faecal metabolomes, which are largely restored to ‘normal’ following recolonization. Recent research indicates that the microbial metabolites can be predictive of response to drug treatment and to diet. This presentation describes the use of metabolic profiling to evaluate the impact of the gut microbiome on human health and focuses on applications in early and later life.https://cassyni-user-files-prod.s3.amazonaws.com/oCSu3MSvAHfCmzB7yPRRY https://cassyni.com/slides/outline/X6d9ozoA7w886CHNYxwKvu https://cassyni.com/events/X6d9ozoA7w886CHNYxwKvu/abstract https://cassyni-user-files-prod.s3.amazonaws.com/X2Q4XDcuuYZuNKnBcXyDVQ https://cassyni.com/events/X6d9ozoA7w886CHNYxwKvu?videoPreview=1 Vortex-dominated flows: Can’t live with them…Can’t live without them…nohttps://cassyni.com/events/X6d9ozoA7w886CHNYxwKvu?videoPreview=12024-02-14T11:00:00+00:003292.04Department of Aeronautics and AstronauticsVortex-dominated flows are in abundance in engineering applications and natural environment. Vortical structures influence not only the flow field but also have major implications on forces and moments experienced by objects as well as noise generated by them. If we can predict/infer the presence and characteristics of vortices, then we might be able to harness their potential to our benefit. In this talk, I will present experimental results from two case studies where vortical structures lead to detrimental performance in one and improved efficiency in the other. These examples come from varied application areas including flow past bluff bodies to underwater autonomous vehicles. https://cassyni-user-files-prod.s3.amazonaws.com/X2Q4XDcuuYZuNKnBcXyDVQ https://cassyni.com/slides/outline/RfVWJUgPHu33hL38x3wXwT https://cassyni.com/events/RfVWJUgPHu33hL38x3wXwT/abstract https://cassyni-user-files-prod.s3.amazonaws.com/BQoh55QPaEp3okaz6xa1Pk https://cassyni.com/events/RfVWJUgPHu33hL38x3wXwT?videoPreview=1 AI Transparency as the magic pill?nohttps://cassyni.com/events/RfVWJUgPHu33hL38x3wXwT?videoPreview=12024-08-30T11:00:00+00:005368.72SACLAs artificial intelligence (AI) gains prominence, managing its associated risks and challenges will become increasingly paramount. This presentation explores the value of AI transparency as the “magic pill” in inspiring more ethical, responsible and trustworthy AI systems. Using two case studies located in the public sector and popular chatbots, the presentation endeavours to provide a nuanced perspective on the role of transparency as it applies to diverse contexts. Additionally, the presentation considers the limitations of the transparency ideal, aiming to stimulate new perspectives and discussions on how transparency can be more effectively conceptualized and operationalized.https://cassyni-user-files-prod.s3.amazonaws.com/BQoh55QPaEp3okaz6xa1Pk https://cassyni.com/events/6QCwVpSvB3SAvjze2kMEFF/abstract https://cassyni-user-files-prod.s3.amazonaws.com/3MDhX8BuE8W3bMw928Ghxa https://cassyni.com/slides/outline/XazXiPHpXnQxJQcUCpjSAH https://cassyni.com/events/XazXiPHpXnQxJQcUCpjSAH/abstract https://cassyni-user-files-prod.s3.amazonaws.com/KH6xbxsBqgpssYqLebdZLr https://cassyni.com/events/XazXiPHpXnQxJQcUCpjSAH?videoPreview=1 Stability analysis and post-instability behavior of spinning fluid-conveying pipes with structural dampingnohttps://cassyni.com/events/XazXiPHpXnQxJQcUCpjSAH?videoPreview=12025-06-24T10:00:00+00:00739.28NODYSThe nonlinear dynamics and stability of fluid-conveying pipes rotating about their longitudinal axis, incorporating structural damping, are investigated in this study. The stability region is investigated, and post-instability behavior is explored, with emphasis on the influence of rotational speed on stability in the presence of internal damping. This research contributes to a deeper understanding of nonlinear vibrations and structural stability in spinning fluid-conveying pipes.https://cassyni-user-files-prod.s3.amazonaws.com/KH6xbxsBqgpssYqLebdZLr https://cassyni.com/slides/outline/U8TJPbm9TaYKGiJuZAMUdT https://cassyni.com/events/U8TJPbm9TaYKGiJuZAMUdT/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Dbg8gjSYCHPrCW8h9FmcGE https://cassyni.com/events/U8TJPbm9TaYKGiJuZAMUdT?videoPreview=1 A deep learning approach for reduced-order modelling of nonlinear structuresnohttps://cassyni.com/events/U8TJPbm9TaYKGiJuZAMUdT?videoPreview=12025-06-24T10:00:00+00:00910.24NODYSModern engineering systems, such as complex space or civil structural systems, often exhibit high degrees of freedom, say, 105-106, which are typical examples of high-dimensional nonlinear dynamic systems. These systems pose a huge challenge for fast response prediction, which essentially requires low-dimensional or reduced-order modelling. This talk introduces a deep learning-based nonlinear model reduction algorithm, which leverages Autoencoder networks for feature extraction, representing dominant variables of nonlinear structure, and Transformer networks for modelling/prediction of evolution in the latent space, i.e., reduced dynamics. The trained model is computationally efficient compared to traditional brute-force simulation of multi-mode Galerkin models, and reliable results for different excitation frequencies also demonstrate its well generalization.https://cassyni-user-files-prod.s3.amazonaws.com/Dbg8gjSYCHPrCW8h9FmcGE https://cassyni.com/slides/outline/6taKQCwaatj18xKjgc9LUd https://cassyni.com/events/6taKQCwaatj18xKjgc9LUd/abstract https://cassyni-user-files-prod.s3.amazonaws.com/GgjAE1EZwPrWKtzNEy3dSv https://cassyni.com/events/6taKQCwaatj18xKjgc9LUd?videoPreview=1 Independent Control of Multiple Microrobots Based on Coil Array Magnetic Actuation Systemnohttps://cassyni.com/events/6taKQCwaatj18xKjgc9LUd?videoPreview=12025-06-24T10:00:00+00:00769.08NODYSIndependent control of magnetic microrobot teams is a major challenge in the field of micro/nano manipulation. In this work, we introduce a coil array magnetic actuation platform that can generate a series of localized magnetic fields for parallel actuation of more than one microrobot for cooperative tasks. An optimized coil structure is first designed to produce uniformly distributed magnetic fields, which lies in accurate and flexible control of microrobots. Then, a current calculation scheme for the coil is established, based on the visual feedback, discrete closed-loop motion control of multiple microrobots between any two equilibrium points is realized. Subsequently, considering the physical and actuation constraints associated with the system, we apply a conflict-based search path planning strategy that add distance limits to generate collision-free paths for all microrobots. Finally, the developed system is tested with extensive physical experiments. The results impressively demonstrated the effectiveness of the devised platform and the proposed methods.https://cassyni-user-files-prod.s3.amazonaws.com/GgjAE1EZwPrWKtzNEy3dSv https://cassyni.com/slides/outline/JkASdEz4XEwpEfJPqhi5fj https://cassyni.com/events/JkASdEz4XEwpEfJPqhi5fj/abstract https://cassyni-user-files-prod.s3.amazonaws.com/CN4852Kj6e1ehFf8nWi2BY https://cassyni.com/events/JkASdEz4XEwpEfJPqhi5fj?videoPreview=1 Can truly nonlinear dynamics be linearized?nohttps://cassyni.com/events/JkASdEz4XEwpEfJPqhi5fj?videoPreview=12025-07-09T16:00:00+00:00798.64NODYSLinearization is a powerful tool for assessing, understanding, and controlling complex nonlinear systems. Traditionally, such approaches have been limited to small regions of the phase space. However, recent advances—particularly those based on Koopman operator theory—have extended the validity of linearization techniques to larger domains. Despite this progress, their limitations for truly nonlinear systems, such as those with coexisting attractors, have been pointed out. This raises a fundamental question: Can truly nonlinear dynamics be linearized? In this talk, we answer this question affirmatively for prototypical nonlinear systems with i) a continuous spectrum, ii) limit cycles, and iii) coexisting solutions. We explicitly construct linear systems that replicate these nonlinear behaviors and employ deep learning to approximate a mapping between linear and nonlinear dynamics. This approach yields low-dimensional linearizations in closed form. We illustrate this approach through application to hallmark nonlinear systems: the pendulum, the Duffing oscillator, and the Van-der-Pol oscillator. Finally, we compare our method to existing linearization techniques and discuss its implications for studying bifurcations.https://cassyni-user-files-prod.s3.amazonaws.com/CN4852Kj6e1ehFf8nWi2BY https://cassyni.com/slides/outline/EnycFmos1aWfSzqiSb834q https://cassyni.com/events/EnycFmos1aWfSzqiSb834q/abstract https://cassyni-user-files-prod.s3.amazonaws.com/X79dn3WBx2E91uFLN4UFZY https://cassyni.com/events/EnycFmos1aWfSzqiSb834q?videoPreview=1 Dynamic mode decomposition for gyrokinetic eigenmode analysisnohttps://cassyni.com/events/EnycFmos1aWfSzqiSb834q?videoPreview=12025-07-24T15:00:00+00:002566.48Journal of Plasma PhysicsPlasma confinement in tokamaks is generally degraded by turbulence. This turbulence is associated with drift instabilities with short wavelengths across the magnetic field lines (typically comparable to Larmor radii). Various branches of such drift instabilities often co-exist, which significantly complicates microstability analysis of electromagnetic fusion plasmas, particularly, in relevance to scenario predictions in the presence of energetic particles and impurities. Drift instabilities are typically described by gyrokinetic theory and simulations. Gyrokinetic initial value solvers, while being well-suited to identifying dominant branches of drift wave eigenmodes, are not able to detect subdominant or stable branches (including branches only slightly less unstable than a dominant instability). To resolve subdominant modes, in the past, two types of gyrokinetic eigenvalue solvers have been developed: computationally expensive distribution function eigenvalue solvers and more efficient numerically gyrokinetic Maxwell dispersion relation solvers. While the latter can allow one to explore various gyrokinetic models and/or drift instabilities (e.g. thresholds of kinetic ballooning modes, closely spaced hybrid eigenmodes, global effects etc.), it is mathematically challenging to retain the majority of these effects simultaneously within one eigensolver. In this talk, we will present a different approach to compute dominant, subdominant and stable gyrokinetic eigenmodes in fusion plasmas without setting any restrictions on the plasma shape, beta (ratio of the plasma pressure to the magnetic field pressure), collisionality, number and type of plasma species. The approach is based on a dimensionality reduction algorithm called dynamic mode decomposition (DMD). DMD is a data-driven technique for performing spectral analysis of time series data via constructing a lower dimensional, linear dynamical model. The linear model is characterised by a set of spatial and temporal modes, to be obtained from eigenvalues and eigenvectors of a linear operator. In this talk, DMD is applied to the gyrokinetic-Maxwell system of the CGYRO gyrokinetic code via a newly developed CGYRO-DMD post-processor. The approach is numerically efficient and adds no cost to a typical gyrokinetic initial value problem. The CGYRO-DMD performance is illustrated for conventional, core tokamak plasmas; spherical tokamak (ST) like plasmas and for the high confinement, H-mode pedestal plasmas. https://cassyni-user-files-prod.s3.amazonaws.com/X79dn3WBx2E91uFLN4UFZY https://cassyni.com/slides/outline/FHdDJTTPT34iSmNc32QqL9 https://cassyni.com/events/FHdDJTTPT34iSmNc32QqL9/abstract https://cassyni-user-files-prod.s3.amazonaws.com/RvLnnsDBLiRA8kQsw1xT8A https://cassyni.com/events/FHdDJTTPT34iSmNc32QqL9?videoPreview=1 Particle Energization in Magnetic Reconnection Jetsnohttps://cassyni.com/events/FHdDJTTPT34iSmNc32QqL9?videoPreview=12025-03-20T15:00:00+00:002531.96Journal of Plasma PhysicsMagnetic reconnection is a fundamental plasma process that converts electromagnetic energy into particle acceleration and bulk plasma motion, driving some of the most energetic events in the Universe. In this study, we investigate how reconnection outflows transfer energy to the surrounding plasma using data from NASA’s Magnetospheric Multiscale (MMS) spacecraft in Earth’s magnetotail. Our analysis shows that turbulence generated within the reconnection outflow plays a key role in energy dissipation. Specifically, thermal ions are rapidly scattered and heated due to their interaction with strongly curved magnetic fields, while the convective electric field further accelerates higher-energy ions. Additionally, we find that electrons are efficiently heated by a magnetic field-aligned electric field, which arises to maintain charge neutrality. These findings provide new insights into energy dissipation and particle energization mechanisms in magnetic reconnection, improving our understanding of plasma dynamics in space and astrophysical environments.https://cassyni-user-files-prod.s3.amazonaws.com/RvLnnsDBLiRA8kQsw1xT8A https://cassyni.com/slides/outline/9rVZnwLcczye3u8NS7R3Lh https://cassyni.com/events/9rVZnwLcczye3u8NS7R3Lh/abstract https://cassyni-user-files-prod.s3.amazonaws.com/UducYdGZkjThLBXzjUTM7t https://cassyni.com/events/9rVZnwLcczye3u8NS7R3Lh?videoPreview=1 Plasma physics in strong laser fieldsnohttps://cassyni.com/events/9rVZnwLcczye3u8NS7R3Lh?videoPreview=12024-09-26T15:00:00+00:004070.4Journal of Plasma PhysicsPlasma behavior in extremely strong background electromagnetic fields is substantially modified from that of classical plasma owing to the onset of relativistic quantum electrodynamics (QED) processes. These processes include the stochastic emission of photons by electrons and the decay of a photon into an electron-positron pair. They are important because electron kinetic behavior is affected by momentum loss during the emission of energetic photons (known as “radiation reaction”), and plasma density may continuously vary over time through pair production. Such plasma behavior may be observed in extreme astrophysical environments and in focused laser light at the highest intensities. The coupling of quantum emission processes and relativistic collective particle dynamics results in dramatically new plasma physics phenomena, such as the generation of dense electron-positron pair plasma from near vacuum, complete laser energy absorption through QED processes, modified plasma dispersion properties, and anomalous particle trapping phenomena. This talk will review the fundamental physics of QED in strong fields and address open questions, provide an overview of pioneering experiments conducted in the laboratory, discuss theoretical and computational advances aimed at understanding plasma in strong fields, and explore upcoming and future research involving ultra-high-intensity lasers and high-energy beam facilities worldwide.https://cassyni-user-files-prod.s3.amazonaws.com/UducYdGZkjThLBXzjUTM7t https://cassyni.com/events/NCjJ4f2czokE644ah2vD7T/abstract https://cassyni-user-files-prod.s3.amazonaws.com/XWckQ5wxWT7EmfSusewaLn https://cassyni.com/events/QfyKJ5GFC6WiSzY9EipqqP/abstract https://cassyni-user-files-prod.s3.amazonaws.com/CVgcEQ491gjFDQSgD5wJbQ https://cassyni.com/events/HGFFbpZNcEDCgxMEgZDDPK/abstract https://cassyni-user-files-prod.s3.amazonaws.com/JGHvaGgYY7qGogEriNWTSN https://cassyni.com/events/KjVGqEnzoWyh3tpoEF7r7F/abstract https://cassyni-user-files-prod.s3.amazonaws.com/LjXwogvAjQbmAciRG4R6AJ https://cassyni.com/slides/outline/Y5hNzKy7mxpYwa4cCbgaFP https://cassyni.com/events/Y5hNzKy7mxpYwa4cCbgaFP/abstract https://cassyni-user-files-prod.s3.amazonaws.com/EvcFFjQ19JuwdTpRPuGyuY https://cassyni.com/events/Y5hNzKy7mxpYwa4cCbgaFP?videoPreview=1 Fast Magnetic Reconnectionnohttps://cassyni.com/events/Y5hNzKy7mxpYwa4cCbgaFP?videoPreview=12021-09-09T15:00:00+00:003228.76Journal of Plasma PhysicsWhen a magnetic field undergoes a near-ideal evolution that involves all three spatial coordinates, mathematics and Maxwell's equations give a characteristic time scale for the initiation of reconnection. This time is given by the ideal evolution multiplied by a factor that depends only logarithmically on the strength of the non-ideal effects. The critical mathematical concept is chaos, which means the streamlines of the ideal flow of the magnetic field lines can separate exponentially in time. The mathematics of vector representations in three dimensions together with Faraday's law define the ideal flow velocity of magnetic field lines as well as an electromotive-like constant on each line which gives the non-ideality. Maxwell's equations imply chaotic flows are energetically impossible in a two-dimensional evolution, which makes conventional two-dimensional reconnection theory an extremely specialized subject. The magnitude of the current density in a three-dimensional reconnection depends only logarithmically on the strength of the non-ideal effects instead of being inversely proportional as in two dimensions. The current density lies in numerous thin but wide ribbons along the magnetic field lines. The concepts that underlie three-dimensional reconnection theory are unfamiliar to the plasma physics community. The talk will both explain these concepts and give simple examples of their application. To ensure those who would like have time to assess unfamiliar concepts, the slides that will be used are attached here (opens in a new tab) .https://cassyni-user-files-prod.s3.amazonaws.com/EvcFFjQ19JuwdTpRPuGyuY https://cassyni.com/slides/outline/SeZjUorLwvjUYhpNbggnFw https://cassyni.com/events/SeZjUorLwvjUYhpNbggnFw/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Vd1hSXdAifRkwbmzFEDN9k https://cassyni.com/events/SeZjUorLwvjUYhpNbggnFw?videoPreview=1 Tokamak turbulence stabilization by electromagnetic effects and fast ionsnohttps://cassyni.com/events/SeZjUorLwvjUYhpNbggnFw?videoPreview=12022-02-24T16:00:00+00:003329.36Journal of Plasma PhysicsA decade ago the experimental discovery on JET that ion temperature profile stiffness (due to the strength of turbulence reaction to changes in ion temperature normalized gradient) is reduced by increased Neutral Beam and/or Ion Cylotron Resonant Heating power triggered an intense work to understand and reproduce/expand these results. The JET results were explained by means of gyrokinetic simulations as due to non-linear electromagnetic stabilization of ion turbulence associated with pressure gradients (including thermal and suprathermal components). In both JET and ASDEX-Upgrade evidence has been found that these mechanisms are at the basis of improved ion confinement and ion temperature peaking in high power Hybrid scenarios. On DIII-D a similar stabilizing effect was found. An additional mechanism linked to a purely fast ion driven resonant linear electrostatic stabilization has been found in JET high ICRH power discharges and very recently used in ASDEX-Upgrade to design pulses with improved ion temperature peaking. Significant progress has been achieved in the theoretical understanding of these stabilizing effects and work is still in progress to better understand the extrapolability to ITER conditions, especially in presence of highly energetic α particles. This talk will present an overview of the experimental and theoretical work on this topic and will discuss its impact on our predictive capabilities of tokamak scenarios.https://cassyni-user-files-prod.s3.amazonaws.com/Vd1hSXdAifRkwbmzFEDN9k https://cassyni.com/events/T9DLXVVsPPHXYUMGC7yaXF/abstract https://cassyni.com/events/5uLMY6gJWhUDQiN6KZmSNR/abstract https://cassyni.com/slides/outline/CJhYo4WSuwUHeGWPb2DjPj https://cassyni.com/events/CJhYo4WSuwUHeGWPb2DjPj/abstract https://cassyni-user-files-prod.s3.amazonaws.com/4CvpnSvM4foVuCHyatWuTL https://cassyni.com/events/CJhYo4WSuwUHeGWPb2DjPj?videoPreview=1 Comparison of antegrade and retrograde percutaneous gastrostomy techniques in childrennohttps://cassyni.com/events/CJhYo4WSuwUHeGWPb2DjPj?videoPreview=12025-10-14T09:49:25+00:00860.68Society for Pediatric Interventional Radiology## Introduction We compare procedural outcomes, adverse events, and efficacy of antegrade and retrograde percutaneous gastrostomy techniques in a pediatric cohort. ## Materials and Methods This was a retrospective analysis of 128 gastrostomy procedures—64 antegrade (performed between 10/2020 and 03/2024) and 64 retrograde (between 10/2018 and 01/2024). Patient data and procedure details, including procedure time, fluoroscopy time, radiation dose, technical success, and adverse events (AE) were collected. ## Results The antegrade group was younger (median age 1.9years vs. 12.0y) and smaller (median weight 11.5kg vs. 31.2kg) than the retrograde group (p<0.001). Antegrade group had similar mean procedure (67.0minutes±32.8min vs. 69.5min±25.9 minutes, p=0.64) and fluoroscopy times (8.0min±6.0min vs. 9.1 ± 7.8 minutes, p=0.35) compared to retrograde. Technical success was 100% for antegrade and 96.9% for retrograde (62/64, p = 0.50). No major AE occurred in either group. However, minor AE (e.g., small pneumoperitoneum, gastropexy anchor malposition, and rectus hematoma) were more frequent with the retrograde approach (0% vs 15.6%, p = 0.001). Radiation exposure (median dose-area-product) was higher in the retrograde group (60.6Gy·cm² vs. 18.5Gy·cm², p < 0.001). Both techniques achieved comparable outcomes, with a median weight gain at 3 months of ~1 kg in each group (p=0.94). All antegrade patients required an additional procedure under anesthesia for conversion to a low-profile gastrostomy button within 3 months, whereas buttons were placed primarily for the retrograde group. ## Discussion Both antegrade and retrograde gastrostomy techniques demonstrated high technical success and efficacy. Retrograde placement was performed in larger children and avoided a subsequent procedure for conversion to a gastrostomy button.https://cassyni-user-files-prod.s3.amazonaws.com/4CvpnSvM4foVuCHyatWuTL https://cassyni.com/slides/outline/RemKL7HLpWx9tuvhXHY3XK https://cassyni.com/events/RemKL7HLpWx9tuvhXHY3XK/abstract https://cassyni-user-files-prod.s3.amazonaws.com/5cn2RkdFrkBexJXrY3JRuG https://cassyni.com/events/RemKL7HLpWx9tuvhXHY3XK?videoPreview=1 Effective boundary conditions at a regularly microstructured wallnohttps://cassyni.com/events/RemKL7HLpWx9tuvhXHY3XK?videoPreview=12019-12-06T13:00:00+00:003298.88UK Fluids NetworkThe talk will discuss effective boundary conditions, correct to second order in a small parameter epsilon, for a rough wall with periodic micro-indentations. The length scale of the indentations is l, and epsilon = l/L << 1, with L a characteristic length of the macroscopic problem. At leading order the Navier slip condition is recovered; at next order the slip velocity includes a term arising from the streamwise pressure gradient. At second order also a transpiration velocity appears at the fictitious wall where the effective boundary conditions are enforced. For ease of derivation, the microscopic theory, based on a power series expansion of the dependent variables, will be limited to the case of two- dimensional roughness, the three-dimensional extension being trivial. The application to a macroscopic problem is carried out considering the case of the Hiemenz stagnation point flow over a rough wall.https://cassyni-user-files-prod.s3.amazonaws.com/5cn2RkdFrkBexJXrY3JRuG https://cassyni.com/slides/outline/4uvezDKi2LfAAMLL3A9gGD https://cassyni.com/events/4uvezDKi2LfAAMLL3A9gGD/abstract https://cassyni-user-files-prod.s3.amazonaws.com/7bNScVDMcaQ3eFiJaC2Y5c https://cassyni.com/events/4uvezDKi2LfAAMLL3A9gGD?videoPreview=1 Thermoacoustic instability: acoustic, flame and flow interactionsnohttps://cassyni.com/events/4uvezDKi2LfAAMLL3A9gGD?videoPreview=12020-01-16T16:00:00+00:003084.24UK Fluids NetworkThermoacoustic instability is caused by interactions between acoustic waves, flames and flow. It leads to damaging oscillations in the combustors of aero-engines, rocket engines, gas turbines and boilers. Carbon-free fuels like hydrogen and ammonia show increased propensity to thermoacoustic instability, and the design of futuristic aerospace engines is dependent on being able to avoid it. Because of the range of length scales involved - from the tiny flame front wrinkling to the long acoustic wavelengths - computational prediction is a real challenge. This talk will explore the acoustic, flame and flow interactions which underpin thermoacoustic instability. We will consider the response of the flame to acoustic waves, the damping of acoustic waves at area expansions with flow separation, and the importance of “entropy noise” - the noise generated when temperature fluctuations undergo a flow acceleration. The implications for efficient computational prediction will be discussed.https://cassyni-user-files-prod.s3.amazonaws.com/7bNScVDMcaQ3eFiJaC2Y5c https://cassyni.com/slides/outline/DJwvmqKdV859Kggo71UjV7 https://cassyni.com/events/DJwvmqKdV859Kggo71UjV7/abstract https://cassyni-user-files-prod.s3.amazonaws.com/7avV9jgypH5BDWvGqGgSX8 https://cassyni.com/events/DJwvmqKdV859Kggo71UjV7?videoPreview=1 Artificial Intelligence: Methods, Clinical Decision Support and Ethicsnohttps://cassyni.com/events/DJwvmqKdV859Kggo71UjV7?videoPreview=12022-09-20T04:00:00+00:003641.52The Auckland Bioengineering InstituteArtificial intelligence and machine learning are one of our era's most exciting methodological developments. It holds the potential to transform healthcare into a system where humans and machines work together to provide better treatment for our patients. In this talk, I give an overview of the core concepts of artificial intelligence, particularly contemporary deep-learning methods, to give researchers an appreciation of how artificial intelligence can be harnessed to support clinical decisions. I will clarify and emphasise the data quality and the human expertise needed to build robust clinical artificial intelligence models in clinical populations. As artificial intelligence is a rapidly evolving field, I take the opportunity to iterate important ethical principles to guide science and medicine as it moves into an artificial intelligence-enhanced future.https://cassyni-user-files-prod.s3.amazonaws.com/7avV9jgypH5BDWvGqGgSX8 https://cassyni.com/slides/outline/FnBx1FZFgQqdgdAMehPND3 https://cassyni.com/events/FnBx1FZFgQqdgdAMehPND3/abstract https://cassyni-user-files-prod.s3.amazonaws.com/2Z9eqRaZKT33Q7F2UFnb4a https://cassyni.com/slides/outline/8rimksHVtx7mVGMm9frNZ3 https://cassyni.com/events/8rimksHVtx7mVGMm9frNZ3/abstract https://cassyni-user-files-prod.s3.amazonaws.com/9mQW5RfiX5VyzQrfUwQKKk https://cassyni.com/events/8rimksHVtx7mVGMm9frNZ3?videoPreview=1 Ultra-sensitive Plasmonic Biosensors based on Two-Dimensional NanoMaterialsnohttps://cassyni.com/events/8rimksHVtx7mVGMm9frNZ3?videoPreview=12023-01-17T14:00:00+00:003913.64MetaMATSurface plasmon resonance sensors are commonly used an effective tool for real-time monitoring biomolecular interactions. The sensing mechanism is based on the evanescent field perturbation at the metallic sensing substrate induced by the binding of chemical and biological molecules. Molecular binding interactions could be measured from the signal of reflected light, under the condition that the surface plasmon resonance is excited by the incident light. In this talk, I will present the use of hybrid 2D nanomaterials-based metasurface nanostructure as an enhanced sensing substrate. The thickness of the plasmonic sensing substrate is tuned in an atomic scale and optimized to improve the sensing capability. Here, both a sharp phase signal change and phase-related Goos-Hänchen signal shift were achieved due to the strong resonance at the surface of the sensing film. The enhanced plasmonic sensitivities of 2D nanostructures were systematically investigated. It is worth noting that the tunability of atomic layer led to the sensing substrate optimized with a narrow scale < 1 nm. Through a precise engineering of the metasurface substrates, 3 orders of magnitude improvement of the sensitivity were demonstrated compared to the one with pure gold sensing substrate. This hybrid 2D nanomaterial-based metasurfaces would provide a good opportunity for developing portable theranostic devices in clinical applications.https://cassyni-user-files-prod.s3.amazonaws.com/9mQW5RfiX5VyzQrfUwQKKk https://cassyni.com/events/BKxnzHX86EtaakAt7517Eu/seminar/qa https://cassyni.com/slides/outline/BKxnzHX86EtaakAt7517Eu https://cassyni.com/events/BKxnzHX86EtaakAt7517Eu/abstract https://cassyni-user-files-prod.s3.amazonaws.com/H8qWQ47v5MqVewwM3MH9xA https://cassyni.com/events/BKxnzHX86EtaakAt7517Eu?videoPreview=1 Depth from Defocus Technique Applied to Unsteady Shock-Drop Secondary atomization, Resolution considerations for structured illumination microscale particle tracking velocimetrynohttps://cassyni.com/events/BKxnzHX86EtaakAt7517Eu?videoPreview=12023-04-04T14:00:00+00:003449.0Experiments in FluidsThe talk will focus on further enhancing a two-sensor depth from defocus (DFD) technique for measuring drop sizes in a spray. The aim is to achieve higher spatial and temporal resolution, to improve estimates of spatial size distribution and number concentration, and to provide additional guidelines for the calibration and design of the optical system for a specific application. The technique and these improvements are demonstrated using the case of secondary atomization when a shock wave interacts with a single drop. This is an application in which both high spatially and temporally resolved number density and size distributions of secondary droplets generated in the wake of the original drop are necessary. In microscale particle velocimetry, the spatial resolution of velocity measurements along the optical axis is often degraded by signal from tracer particles outside the focal plane. Structured illumination microscopy particle tracking velocimetry (SIM PTV) can eliminate most of this out-of-focus signal by using illumination with a non-zero spatial frequency to preferentially illuminate the in-focus particles. Two such (raw) images can then be combined to eliminate the background signal and demodulate the image. The objective of this study was to quantify and optimize the spatial and temporal resolution of SIM PTV based upon Poiseuille flow in a microchannel at Reynolds numbers Re ≈ 0.02. The axial spatial resolution, estimated for this known velocity profile from the standard deviation of the velocity measurements, is improved by at least a factor of 2 compared with the results for a uniformly illuminated flow. This axial spatial resolution is in good agreement with that given by the point spread function of the imaging system derived by Neil et al. (Opt Lett 22:1905-1907, 1997). The spatial frequency of the illumination that optimizes the spatial resolution is a function of the scattering area of the tracer particles. Interestingly, increasing the number of raw images does not appear to improve the axial resolution. Finally, the temporal resolution of SIM PTV is estimated based upon both image and velocity acquisition times.https://cassyni-user-files-prod.s3.amazonaws.com/H8qWQ47v5MqVewwM3MH9xA https://cassyni.com/slides/outline/Ngr4wNtJnQhWyy84mnGLfF https://cassyni.com/events/Ngr4wNtJnQhWyy84mnGLfF/abstract https://cassyni-user-files-prod.s3.amazonaws.com/HSQcxd5wR71g4K81dS9AVt https://cassyni.com/events/Ngr4wNtJnQhWyy84mnGLfF?videoPreview=1 Recent Advances in Shake-the-Box Lagrangian Particle Trackingnohttps://cassyni.com/events/Ngr4wNtJnQhWyy84mnGLfF?videoPreview=12022-09-27T14:00:00+00:003754.16Experiments in Fluids3D Lagrangian particle tracking (LPT) allows for position, velocity, and acceleration to be determined alongside a large number of individual particle tracks in the investigated volume. The advent of the dense 3D LPT technique Shake-The-Box (STB) in the past decade has opened further possibilities for characterizing unsteady flows by delivering input data for statistical analysis and powerful data assimilation techniques that use Navier–Stokes constraints. As a result, high-resolution Lagrangian and Eulerian data can be obtained, including long particle trajectories embedded in time-resolved 3D velocity and pressure fields. In the presentation recent advances in some key aspects of the STB technique will be addressed that aim at higher accuracies and particle image densities. https://cassyni-user-files-prod.s3.amazonaws.com/HSQcxd5wR71g4K81dS9AVt https://cassyni.com/slides/outline/HkN2UYR4PqAVasQimJZLw7 https://cassyni.com/events/HkN2UYR4PqAVasQimJZLw7/abstract https://cassyni-user-files-prod.s3.amazonaws.com/AHEH2X7sp7Sv85QnxgKrV4 https://cassyni.com/events/HkN2UYR4PqAVasQimJZLw7?videoPreview=1 Implementation of the finite in time integration schemenohttps://cassyni.com/events/HkN2UYR4PqAVasQimJZLw7?videoPreview=12022-09-14T15:00:00+00:001686.04NEKTAR++In this short talk Allen Sanderson will describe the implementation of the Finite in Time (FIT) Integration Scheme into Nektar++. The scheme is a fast convolution algorithm for computing solutions to (Caputo) time-fractional differential equations. It is an explicit solver that expresses the solution as an integral over a Talbot curve, which is discretized with quadrature. First-order quadrature is currently implemented.https://cassyni-user-files-prod.s3.amazonaws.com/AHEH2X7sp7Sv85QnxgKrV4 https://cassyni.com/slides/outline/Y5atXouaAX7eMxrr2AY8x5 https://cassyni.com/events/Y5atXouaAX7eMxrr2AY8x5/abstract https://cassyni-user-files-prod.s3.amazonaws.com/J54JhN6w3kVeCwcFGaN9Hg https://cassyni.com/events/Y5atXouaAX7eMxrr2AY8x5?videoPreview=1 The Gamified Survey Taking Process: Developing a Theoretical Frameworknohttps://cassyni.com/events/Y5atXouaAX7eMxrr2AY8x5?videoPreview=12022-10-12T01:00:00+00:002841.88Department of MarketingResearch addressing survey design methodology has been conducted extensively over the last half-century. By comparison, gamification is an under-researched concept in the world of academia. While the fit of gamification and survey design has been recognised, insight into this methodological interface remains tenuous. We develop an integrative framework of the gamified survey taking process, informed by Hunicke, LeBlanc and Zubek’s (2004) MDA Framework for game design, Tondello et al.’s (2016) HEXAD User Types, and Triantoro, Gopal, Benbunan-Fich & Lang’s (2019) three types of survey gamification mechanics. Deploying the framework, we develop several propositions and apply these to the gamified survey taking process. We conclude with theoretical, methodological, and managerial implications, followed with future research avenues.https://cassyni-user-files-prod.s3.amazonaws.com/J54JhN6w3kVeCwcFGaN9Hg https://cassyni.com/events/W6a8ddbBNH1MUYeXjf855F/seminar/qa https://cassyni.com/slides/outline/W6a8ddbBNH1MUYeXjf855F https://cassyni.com/events/W6a8ddbBNH1MUYeXjf855F/abstract https://cassyni-user-files-prod.s3.amazonaws.com/QrBKxUMBRf55BUnDTfPGqL https://cassyni.com/events/W6a8ddbBNH1MUYeXjf855F?videoPreview=1 How will global change affect plant reproduction? A framework for mast seeding trendsnohttps://cassyni.com/events/W6a8ddbBNH1MUYeXjf855F?videoPreview=12022-10-27T13:00:00+00:002356.12New PhytologistForest ecology traditionally focuses on plant growth and survival, leaving seed production as a major demographic process lacking a framework for how it will be affected by global change. Understanding plant reproductive responses to changing climate is complicated by masting, the annually variable seed production synchronized within populations. Predicting trends in masting is crucial, because masting impacts seed predation and pollination enough to override simple trends in mean seed production. Proximate mechanisms of seed production patterns in perennial plants are gathered to identify processes through which masting may be affected by a changing environment. Predicting trends in masting will require understanding the mechanisms that cause predictable seed failure after high-seed years, and the stochastic mechanisms that synchronize individuals in high-seed years. Hosted by New Phytologist Editor Maarja Öpik Banner image by Maxx Gong on Unsplash https://cassyni-user-files-prod.s3.amazonaws.com/QrBKxUMBRf55BUnDTfPGqL https://cassyni.com/slides/outline/YZp9s3poZZmqqV86HM2hoB https://cassyni.com/events/YZp9s3poZZmqqV86HM2hoB/abstract https://cassyni-user-files-prod.s3.amazonaws.com/U3LcC8rZJpdSMPNHjkuJMc https://cassyni.com/events/YZp9s3poZZmqqV86HM2hoB?videoPreview=1 The H0 Olympics: A fair ranking of proposed modelsnohttps://cassyni.com/events/YZp9s3poZZmqqV86HM2hoB?videoPreview=12022-11-14T14:00:00+00:002794.28Physics ReportsDespite the remarkable success of the $\Lambda$ Cold Dark Matter (ΛCDM) cosmological model, a growing discrepancy has emerged (currently measured at the level of ∼4−6$\sigma$) between the value of the Hubble constant $H_0$ measured using the local distance ladder and the value inferred using the cosmic microwave background and galaxy surveys. While a vast array of $\Lambda$CDM extensions have been proposed to explain these discordant observations, understanding the (relative) success of these models in resolving the tension has proven difficult — this is a direct consequence of the fact that each model has been subjected to differing, and typically incomplete, compilations of cosmological data. In this talk, based on the eponymous review paper published in Physics Report, we present the result of a comparison of seventeen different models which have been proposed to resolve the $H_0$ tension (spanning both early- and late-Universe solutions), and quantify the relative success of each using a series of metrics and a vast array of data combinations. We refer to this contest as the “$H_0$ Olympics”; the goal being to identify which of the proposed solutions, and more broadly which underlying mechanisms, are most likely to be responsible for explaining the observed discrepancy (should unaccounted for systematics not be the culprit). This work also establishes a foundation of tests which will allow the success of novel proposals to be meaningfully “benchmarked”.https://cassyni-user-files-prod.s3.amazonaws.com/U3LcC8rZJpdSMPNHjkuJMc https://cassyni.com/slides/outline/8N3YbZ8648dwfoNFMZjQNq https://cassyni.com/events/8N3YbZ8648dwfoNFMZjQNq/abstract https://cassyni-user-files-prod.s3.amazonaws.com/CdCaqHZbNsFfRsGhMLSpDt https://cassyni.com/events/8N3YbZ8648dwfoNFMZjQNq?videoPreview=1 Celebrating Editorial Impactnohttps://cassyni.com/events/8N3YbZ8648dwfoNFMZjQNq?videoPreview=12022-12-13T09:00:00+00:003807.52Topics at the heart of our communityJoin us to celebrate your fellow Editors and learn about the editorial initiatives that have made an impact on their journals. From Editorial Board development to support growth and increase diversity, to the impact of new collections, there’s a lot to celebrate in this December's special edition of the Spotlight On webinar series. https://cassyni-user-files-prod.s3.amazonaws.com/CdCaqHZbNsFfRsGhMLSpDt https://cassyni.com/slides/outline/2vuu631KE6YsGw81kejcPP https://cassyni.com/events/2vuu631KE6YsGw81kejcPP/abstract https://cassyni-user-files-prod.s3.amazonaws.com/TX1TFzfjKVczWABpd7cs7c https://cassyni.com/events/2vuu631KE6YsGw81kejcPP?videoPreview=1 Concluding remarks and some open problemsnohttps://cassyni.com/events/2vuu631KE6YsGw81kejcPP?videoPreview=12021-06-18T15:00:00+00:002159.96Journal of Fluid MechanicsThis series of webinars was planned in commemoration of George Batchelor's promotion of the field of fluid mechanics in all its varied aspects and applications. In rounding off the series, I shall first comment on how much George Batchelor himself would have enjoyed the 15 brilliant presentations that we have heard. It is good to know that our subject is flourishing so vigorously with the young talent that has been so evident through these presentations. I shall use the short time available to me to discuss three questions that I touched on in my JFM Perspectives paper Some topological aspects of fluid dynamics: (i) How are corner eddies affected by increasing the Reynolds number of the remote forcing? ii) How does a sheet of air enter through the free-surface cusp in a tightly controlled situation? (iii) How can knotted or linked magnetic flux tubes most efficiently jump from one minimum-energy state to another?https://cassyni-user-files-prod.s3.amazonaws.com/TX1TFzfjKVczWABpd7cs7c https://cassyni.com/slides/outline/3RZW8ieqfZ6vGheuM62Qeh https://cassyni.com/events/3RZW8ieqfZ6vGheuM62Qeh/abstract https://cassyni-user-files-prod.s3.amazonaws.com/N5sokUYxVTXbNkc2cVNyAE https://cassyni.com/events/3RZW8ieqfZ6vGheuM62Qeh?videoPreview=1 Acrobatics of non-stick dropletsnohttps://cassyni.com/events/3RZW8ieqfZ6vGheuM62Qeh?videoPreview=12021-02-19T16:00:00+00:005096.24Journal of Fluid MechanicsMaking drops non-wetting increases dramatically their mobility, compared to the situations we are used to. We'll describe a few consequences of this statement, with a particular focus on jumping droplets: two non-stick drops can transfer their surface energy into kinetic energy when they merge, and thus can jump from their substrate. The materials achieving such a property might be antifogging, since condensing water is likely to be evacuated without external source of energy. We’ll discuss to what extent this optimistic view is science-fiction - wearing glasses at the time of covid, we realize how non-antifogging common materials arehttps://cassyni-user-files-prod.s3.amazonaws.com/N5sokUYxVTXbNkc2cVNyAE https://cassyni.com/slides/outline/DoBC75ErtAjLoCx3NByJLD https://cassyni.com/events/DoBC75ErtAjLoCx3NByJLD/abstract https://cassyni-user-files-prod.s3.amazonaws.com/jENX572cXXLZ9UrjigzTG https://cassyni.com/events/DoBC75ErtAjLoCx3NByJLD?videoPreview=1 Active exterior cloaking for the heat equationnohttps://cassyni.com/events/DoBC75ErtAjLoCx3NByJLD?videoPreview=12022-07-04T16:10:00+00:001820.04ETOPIMWe present a method for cloaking objects from thermal measurements that uses active sources instead of exotic materials and where the sources do not completely surround the object to cloak. Rather than working with the heat equation in the time domain as in [3], our method relies on the frequency domain formulation as Helmholtz equation solutions with complex wavenumbers. This extends the active exterior cloaking for the Helmholtz equation method in [2] from positive wavenumbers to complex ones. In addition, we give convergence estimates for this cloaking approach[4]. We believe the same approach applies to cloaking in dispersive media.https://cassyni-user-files-prod.s3.amazonaws.com/jENX572cXXLZ9UrjigzTG https://cassyni.com/slides/outline/ALdxnHiBoxrhmWeUiXbLoP https://cassyni.com/events/ALdxnHiBoxrhmWeUiXbLoP/abstract https://cassyni-user-files-prod.s3.amazonaws.com/7EXd8gY91XFFh8jYq4JF5g https://cassyni.com/events/ALdxnHiBoxrhmWeUiXbLoP?videoPreview=1 Near-field characterization of surface plasmon polaritons on single-crystalline gold plateletsnohttps://cassyni.com/events/ALdxnHiBoxrhmWeUiXbLoP?videoPreview=12022-07-07T07:00:00+00:001301.08ETOPIMThe subwavelength confinement of surface plasmon polaritons (SPPs) makes them useful for various applications such as nanoplasmonic circuits, light generation and solar energy conversion. Scattering-type scanning near-field optical microscopes (s-SNOM) allow the direct measurement of the SPPs. However, in a reflection configuration, their full quantitative characterization is challenging because of complex wave patterns resulting from the interference between several excitation pathways. In a previous study, it has been shown that the wavelength of the SPPs launched by a s-SNOM tip (called tip-launched SPPs) could be retrieved by analyzing the s-SNOM signal far from the edges of the platelets [1]. In this study, we present results from the interferometric near-field measurements of both the amplitude and phase of SPPs on large single-crystalline gold platelets in the visible spectral range [2]. We study systematically the influence of the angle of the incident light on the SPPs. We find that the signal of the tip launched SPPs is best disentangled from other signals at grazing incident angle relative to the platelet’s edge. Moreover, we introduce a simple theoretical model to explain the π/2 phase shift observed between the SPP amplitude and phase profiles. Using this model, the wavelength Λtl and propagation length Ltlp of the tip-launched SPPs are retrieved by isolating and fitting their signals far from the edges. Our experimental results are in excellent agreement with our model using gold refractive index values from the literature. The presented method to fully characterize the SPP complex wavevector could enable the quantitative analysis of polaritons occurring in different materials in the visible range.https://cassyni-user-files-prod.s3.amazonaws.com/7EXd8gY91XFFh8jYq4JF5g https://cassyni.com/slides/outline/Cosz1hwp1FdC8T83GDVyXK https://cassyni.com/events/Cosz1hwp1FdC8T83GDVyXK/abstract https://cassyni-user-files-prod.s3.amazonaws.com/2QcuXoAAGjQ5y6vpE6G4rJ https://cassyni.com/events/Cosz1hwp1FdC8T83GDVyXK?videoPreview=1 Time-varying and reconfigurable driven photonicsnohttps://cassyni.com/events/Cosz1hwp1FdC8T83GDVyXK?videoPreview=12022-07-08T08:30:00+00:001256.04ETOPIMMetamaterials have revolutionised the way we control light transport and generation. Yet, to date, they rely on passive architectures, only redistributing incident wave energy - for example in a metalens, or a cloak - with no power to locally absorb or produce it to enhance responses. Here I will discuss our first steps towards driven photonic systems, able to convert energy to function and perform actions.https://cassyni-user-files-prod.s3.amazonaws.com/2QcuXoAAGjQ5y6vpE6G4rJ https://cassyni.com/slides/outline/PgAu9NhF4gjPoCeUAKg76m https://cassyni.com/events/PgAu9NhF4gjPoCeUAKg76m/abstract https://cassyni-user-files-prod.s3.amazonaws.com/PwJpg3EB8vbxeTThXFowhg https://cassyni.com/events/PgAu9NhF4gjPoCeUAKg76m?videoPreview=1 Toroidal plasmoid generation via extreme hydrodynamic shearnohttps://cassyni.com/events/PgAu9NhF4gjPoCeUAKg76m?videoPreview=12020-10-16T15:00:00+00:003513.84Journal of Fluid MechanicsSaint Elmo's fire and lightning are two known forms of naturally occurring atmospheric pressure plasmas. As a technology, non-thermal plasmas are induced from artificially created elecromagnetic or elecrostatic fields. Here we report the observation of arguably a unique case of a naturally formed such plasma created in the air at room temperature without external electromagnetic action, by impinging a high-speed microjet of deionized water on a dielectric solid surface. We demonstrate that tribo-electrification from extreme and focused hydrodynamic shear is the driving mechanism for the generation of energetic free electrons. Air ionization results in a plasma that, unlike the general family, is topologically well defined in the form of a coherent toroidal structure. Possibly confined through its self-induced electromagnetic field, this plasmoid is shown to emit strong luminescence and discrete frequency radio waves. Our experimental study suggests the discovery of a unique platform to support experimentation in low-temperature plasma science.https://cassyni-user-files-prod.s3.amazonaws.com/PwJpg3EB8vbxeTThXFowhg https://cassyni.com/slides/outline/LDdfpbAZzUrkmWLuWfJ9Zw https://cassyni.com/events/LDdfpbAZzUrkmWLuWfJ9Zw/abstract https://cassyni-user-files-prod.s3.amazonaws.com/UgP2zyyBAR4WjetW1rSjzN https://cassyni.com/events/LDdfpbAZzUrkmWLuWfJ9Zw?videoPreview=1 Pairs of commuting contractions: Ando lifts and functional modelsnohttps://cassyni.com/events/LDdfpbAZzUrkmWLuWfJ9Zw?videoPreview=12022-05-05T17:00:00+00:003114.56Acta Scientiarum MathematicarumThe Wold decomposition for an isometric Hilbert-space operator leads to a functional model for such an operator: the shift operator on a vectorial Hardy space direct sum with a unitary operator for which there is a good spectral theory (complete unitary invariants consisting of the scalar spectral measure together with multiplicity function on the unit circle). Sz.-Nagy and Foias (late 1960s) showed how to construct a functional model for a completely non-unitary contraction operator $T$ by understanding how to embed such a functional-model space into the Wold-decomposition functional-model for the single product isometry $V=V_1 V_2$. This story extends to the setting of commuting pairs of isometries and commuting pairs of contractions as follows. Berger-Coburn-Lebow (1978) found a functional model for a commuting pair of isometries $(V_1, V_2)$ by using the Wold-decomposition functional-model for the single product isometry $V = V_1 V_2$ as the ambient functional-model space. They also found a complete unitary invariant (a ``BCL tuple” consisting of a Hilbert coefficient space together with a unitary and projection operator on this space) from which one can construct the functional model. In the case where the product isometry is pure, $V$ is multiplication by the coordinate function $z$ while $V_1$ and $V_2$ are equal to multiplication by certain operator pencils with coefficients coming from the BCL tuple. In this talk we discuss the next step: finding a functional model for a commutative pair of contraction operators $(T_1, T_2)$ by seeing how to embed such a space into the BCL functional model for its minimal Ando isometric lift $(V_1, V_2)$. This amounts to finding the models for the commutative operator pair $(T_1, T_2)$ as acting on the Sz.-Nagy-Foias functional-model space for the single product operator $T = T_1 T_2$. Our approach to the Sz.-Nagy-Foias model was inspired by the approach of Douglas (1968). A complete invariant consists of (i) the Sz.-Nagy-Foias characteristic function for the single product contraction operator $T$, (ii) the BCL tuple for the Ando lift $(V_1, V_2)$, and (iii) an embedding operator $\Lambda$ of the defect space of $T^*$ into the defect space of $V^* = V_1^* V_2^*$ which again is subject to some additional operator equations. Part of this construction is a functional model for any Ando lift $(V_1, V_2)$ for the commutative contractive pair $(T_1, T_2)$. Ando lifts are classified by a collection of spaces and operators which we call Ando tuples (the complete unitary invariant for $(T_1, T_2)$ but with the characteristic function $\Theta_T$ for $T = T_1 T_2$ dropped). There is a special class of Ando lifts for which it can be proved that the additional operator equations are automatically satisfied, leading to a new functional-model proof of the Ando dilation theory itself. Parallel results hold for commuting contractive $d$-tuples. The fact that the Ando dilation theorem does not extend in general to commutative contractive $d$-tuples once $d >2$ is explained by the fact that the auxiliary supplementary operator equations fail to hold in general. This is joint work with Haripada Sau of the Indian Institute of Technology Guwahati.https://cassyni-user-files-prod.s3.amazonaws.com/UgP2zyyBAR4WjetW1rSjzN https://cassyni.com/slides/outline/WbFMnwkbD6VBJ1e3XmF3FT https://cassyni.com/events/WbFMnwkbD6VBJ1e3XmF3FT/abstract https://cassyni-user-files-prod.s3.amazonaws.com/TXHsRySijKkxfwMahT9xSS https://cassyni.com/events/WbFMnwkbD6VBJ1e3XmF3FT?videoPreview=1 Skin-Interfaced Wearable Biosensorsnohttps://cassyni.com/events/WbFMnwkbD6VBJ1e3XmF3FT?videoPreview=12023-01-13T05:30:00+00:002905.0Mechanical EngineeringThe rising research interest in personalized medicine promises to revolutionize traditional medical practices. This presents a tremendous opportunity for developing wearable devices toward predictive analytics and treatment. In this talk, I will introduce our efforts in developing wearable biosensors for non-invasive molecular analysis. Such wearables can autonomously access sweat across activities and continuously measure a broad spectrum of analytes including metabolites, nutrients, hormones, and drugs. Laser-engraving and inkjet printing are used to manufacture these nanomaterials-based biosensors at large scale and low cost. The clinical value of our wearable systems is evaluated through human studies toward metabolic & nutritional monitoring, disease diagnosis, mental health assessment, and drug personalization. I will also discuss our research progress on energy harvesting from the body fluids and human motion to realize battery-free wireless wearable sensing. These wearable technologies could open the door to a wide range of personalized monitoring, diagnostic, and therapeutic applications.https://cassyni-user-files-prod.s3.amazonaws.com/TXHsRySijKkxfwMahT9xSS https://cassyni.com/slides/outline/X5txqdQ7eZ3EHnAw8CXqWm https://cassyni.com/events/X5txqdQ7eZ3EHnAw8CXqWm/abstract https://cassyni-user-files-prod.s3.amazonaws.com/UEe4reDYLURf241eGKvt2r https://cassyni.com/events/X5txqdQ7eZ3EHnAw8CXqWm?videoPreview=1 Ring-opening fluorination via C–C bond cleavage: An efficient approach to diverse fluorinated moleculesnohttps://cassyni.com/events/X5txqdQ7eZ3EHnAw8CXqWm?videoPreview=12022-12-06T15:00:00+00:003385.36Tetrahedron Chem and Tetrahedron Green ChemThe unique and desirable properties of fluorinated compounds in pharmaceutical, agrochemical, and materials sciences have driven the development of remote fluorination methods. In particular, the C–C cleavage/fluorination of cyclic molecules recently emerged as one of the most reliable approaches, allowing the efficient construction of otherwise inaccessible fluorinated molecules. While serving as a powerful platform, many ring-opening fluorination methods have relied on the use of expensive and/or low atom-economical electrophilic fluorine sources and often require precious metals such as silver or iridium, impeding their general applications in synthesis and 18F radioisotope studies. In this Perspective, we summarize the recent efforts on the C–C deconstructive fluorination methods, including our new approaches to synthesize remotely-fluorinated ketones, followed by future opportunities of this field toward better sustainability and positron emission tomography (PET) compatibility using earth-abundant element catalysts and simple nucleophilic fluoride salts as fluorine sources.https://cassyni-user-files-prod.s3.amazonaws.com/UEe4reDYLURf241eGKvt2r https://cassyni.com/slides/outline/6PUkXT3shfMH8KtCbywjq7 https://cassyni.com/events/6PUkXT3shfMH8KtCbywjq7/abstract https://cassyni-user-files-prod.s3.amazonaws.com/UYy3SnrvikaWVTAUhTkrAS https://cassyni.com/events/6PUkXT3shfMH8KtCbywjq7?videoPreview=1 New perspectives on rough paths, signatures and signature cumulantsnohttps://cassyni.com/events/6PUkXT3shfMH8KtCbywjq7?videoPreview=12021-05-06T16:00:00+00:003573.64DataSıgWe revisit rough paths and signatures from a geometric and 'smooth model' perspective. This provides a lean framework to understand and formulate key concepts of the theory, including recent insights on higher-order translation, also known as renormalization of rough paths. This first part is joint work with C Bellingeri (TU Berlin), and S Paycha (U Potsdam). In a second part, we take a semimartingale perspective and more specifically analyze the structure of expected signatures when written in exponential form. Following Bonnier-Oberhauser (2020), we call the resulting objects signature cumulants. These can be described - and recursively computed - in a way that can be seen as unification of previously unrelated pieces of mathematics, including Magnus (1954), Lyons-Ni (2015), Gatheral and coworkers (2017 onwards) and Lacoin-Rhodes-Vargas (2019). This is joint work with P Hager and N Tapia.https://cassyni-user-files-prod.s3.amazonaws.com/UYy3SnrvikaWVTAUhTkrAS https://cassyni.com/slides/outline/Szi4cadK5pFjEArbWEk6y https://cassyni.com/events/Szi4cadK5pFjEArbWEk6y/abstract https://cassyni-user-files-prod.s3.amazonaws.com/6BaVCSYDdDsLtFf9g6RZWW https://cassyni.com/events/Szi4cadK5pFjEArbWEk6y?videoPreview=1 Distributed synthesis for local controllers in networked systemsnohttps://cassyni.com/events/Szi4cadK5pFjEArbWEk6y?videoPreview=12023-02-08T16:00:00+00:003097.44Department of Aeronautics In traditional decentralized and distributed control, the subsystem level controllers are constrained to use states from a subset of neighboring subsystems to determine their control actions; however, the process of designing the controllers is centralized and utilizes the knowledge of the dynamics of all subsystems. For large scale systems involving plug and play operations, a distributed synthesis process in which the control synthesis is carried out locally at the subsystem level, without explicit knowledge of the dynamics of other subsystems in the network, may be required. We provide such a control design. We begin with a model based design and then consider the case when accurate models may not be available and a data-driven design is preferable.https://cassyni-user-files-prod.s3.amazonaws.com/6BaVCSYDdDsLtFf9g6RZWW https://cassyni.com/slides/outline/3vEjJ2pFWNak6AeR9C9Npu https://cassyni.com/events/3vEjJ2pFWNak6AeR9C9Npu/abstract https://cassyni-user-files-prod.s3.amazonaws.com/WAfDdRZWyXuTwSe5LRghv6 https://cassyni.com/events/3vEjJ2pFWNak6AeR9C9Npu?videoPreview=1 Two spectral calculations and their applications to PDE analysis of incompressible fluid flowsnohttps://cassyni.com/events/3vEjJ2pFWNak6AeR9C9Npu?videoPreview=12021-11-12T12:00:00+00:004580.64Journal of Mathematical Fluid MechanicsWe will discuss two problems for the incompressible Navier-Stokes equations whose solutions can be obtained via computations of suitable spectra. The first concerns the uniqueness of the Leray-Hopf solutions, where an important spectral computation still needs computer assistance. The second concerns the long-distance behavior of the steady 3d solutions in exterior domains. Here the relevant spectral computations can be done by the traditional 'paper and pencil' methods and one can obtain certain higher-order asymptotics for the solutions that may be somewhat unexpected. The talk is based on joint works with Hao Jia and Julien Guillod.https://cassyni-user-files-prod.s3.amazonaws.com/WAfDdRZWyXuTwSe5LRghv6 https://cassyni.com/events/GGSqT7zNUpRbyqtE7Yi6y3/abstract https://cassyni-user-files-prod.s3.amazonaws.com/UxNXnD2fi1rhm5d846XRxi https://cassyni.com/events/GGSqT7zNUpRbyqtE7Yi6y3?videoPreview=1 Game On Glio Podcastnohttps://cassyni.com/events/GGSqT7zNUpRbyqtE7Yi6y3?videoPreview=12023-02-20T21:00:00+00:001638.32Journal of Neuro-OncologyJoin Dr. Randy D'Amico and Dr. Jason Sheehan from the Journal of Neuro-Oncology for a conversation with the host of the Game On Glio Podcast and founder of Traphagen's Trail Ride 4 Brain Cancer, Shannon Traphagen, to discuss her podcast and her work to increase dialogue on brain cancer and find a cure for glioblastoma. https://cassyni-user-files-prod.s3.amazonaws.com/UxNXnD2fi1rhm5d846XRxi https://cassyni.com/slides/outline/AqKBwbsbenLXaydzWdiJyb https://cassyni.com/events/AqKBwbsbenLXaydzWdiJyb/abstract https://cassyni-user-files-prod.s3.amazonaws.com/WNdoL5UHm7pK6haha7mSWi https://cassyni.com/events/AqKBwbsbenLXaydzWdiJyb?videoPreview=1 Celebrating the launch of Nature Water - Part 1: Focus on water treatment systemsnohttps://cassyni.com/events/AqKBwbsbenLXaydzWdiJyb?videoPreview=12023-02-01T13:00:00+00:003562.96Nature WaterTo celebrate the launch of Nature Water, we have organized a series of webinars with some of the authors from the first issue. In this first webinar, editors Fabio Pulizzi and Shujuan Zhang will be talking to Menachem Elimelech about metal recovery from wastewater and with Bin Liu about his work on electrochemical hydrogenation.https://cassyni-user-files-prod.s3.amazonaws.com/WNdoL5UHm7pK6haha7mSWi https://cassyni.com/slides/outline/NgzBWXTjoDL9ifBvATZt3X https://cassyni.com/events/NgzBWXTjoDL9ifBvATZt3X/abstract https://cassyni-user-files-prod.s3.amazonaws.com/5AWMTuVsJRs5dBn4qjqc6r https://cassyni.com/events/NgzBWXTjoDL9ifBvATZt3X?videoPreview=1 Scalar Velocimetry using Cross-Scanning LIFnohttps://cassyni.com/events/NgzBWXTjoDL9ifBvATZt3X?videoPreview=12024-02-20T15:00:00+00:003112.16Experiments in FluidsVolumetric measurements of three-dimensional velocity fields are most often accomplished by seeding the liquid with small solid particles and then follow them around using multiple cameras. The resolution of this measurement is limited by the size and number of these particles. A second approach is to stir fluorescent dye into the liquid and infer the velocity field from the changes in the volumetric fluorescent field with time, by inverting the advection-diffusion equation. To track changes in the volumetric dye-field, one images its concentration plane-by-plane by illuminating it with a rapidly scanning laser-sheet, each video-frame measuring the intensity in one plane I(x,y). In practice, one can only image 10-100 adjacent planes, to capture the time-variations of the field. The drawback in this approach is the reduced resolution in the scanning z-direction. While you have 1000x1000 pixels in each (x,y)-plane, there are only of the order of 50 planes in the depth. Our approach overcomes this by using two perpendicular scanning directions and two high-speed cameras to record the fluorescent intensity field in (x,y) and (x,z) directions respectively. This will allow much denser velocity measurements in a larger volume. However, the data acquisition and analysis are more complicated than for the single scan direction. Below we describe how this is being implemented, along with preliminary results for a turbulent jet.https://cassyni-user-files-prod.s3.amazonaws.com/5AWMTuVsJRs5dBn4qjqc6r https://cassyni.com/events/GHB2RVPQxCWVnFzfYK7bPB/abstract https://cassyni-user-files-prod.s3.amazonaws.com/9KJVkohoGiHShbu64DxFhY https://cassyni.com/events/6ttAf8cL1ruzkWZznh5Xed/seminar/qa https://cassyni.com/slides/outline/6ttAf8cL1ruzkWZznh5Xed https://cassyni.com/events/6ttAf8cL1ruzkWZznh5Xed/abstract https://cassyni-user-files-prod.s3.amazonaws.com/YDZnrfmstqbYZSbVq7BwK4 https://cassyni.com/events/6ttAf8cL1ruzkWZznh5Xed?videoPreview=1 New bioinformatics resources from The International Cannabis Genome Research Consortiumnohttps://cassyni.com/events/6ttAf8cL1ruzkWZznh5Xed?videoPreview=12024-10-24T11:00:00+00:003423.04GigaScience PressThe International Cannabis Genome Research Consortium (ICGRC) has taken up the task of providing an authoritative source of rigorous and peer-reviewed scientific information relating to Cannabis genetics, genomics and phenotyping. Just out in GigaByte are papers presenting two of these outputs, the CannSeek database bringing together the many genomics datasets, and a community-driven bioinformatics platform to facilitate Cannabis multi-omics research. The papers promoting these resources, providing details on how to use them, and most importantly providing insight into how they were put together. To provide even more insight we are hosting an online seminar with the authors of these papers. Providing an opportunity to get firsthand insight from the authors on why these platforms are important, how you can use them, and the technical details on how they were developed. Also providing an opportunity to ask directly questions to them directly.https://cassyni-user-files-prod.s3.amazonaws.com/YDZnrfmstqbYZSbVq7BwK4 https://cassyni.com/events/QBbwPgmanFDtF5ntYhe4qB/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Gpyh7ywiFTDHyk9KF5QUSJ https://cassyni.com/slides/outline/YaYLqRDr2wrjduEXi7SCDK https://cassyni.com/events/YaYLqRDr2wrjduEXi7SCDK/abstract https://cassyni-user-files-prod.s3.amazonaws.com/8u9JxCbc3Eut5gnGUYvTWE https://cassyni.com/events/YaYLqRDr2wrjduEXi7SCDK?videoPreview=1 The production and transfer of uncertainty in turbulencenohttps://cassyni.com/events/YaYLqRDr2wrjduEXi7SCDK?videoPreview=12024-12-11T14:00:00+00:003132.04Department of AeronauticsTwo nearly identical turbulent velocity fields, initially differing by a very small error/uncertainty at the smallest scales and therefore near-perfectly correlated, gradually decorrelate as they evolve in time by incompressible Navier-Stokes dynamics. Initially this decorrelation is chaotic and characterised by a positive maximal Lyapunov exponent. Eventually it becomes stochastic and characterised by a power law growth of average uncertainty. Both uncertainty growth regimes are determined by turbulent compressive motions, via one-point strain rate statistics for the production of increasing uncertainty, and via two-point deformation rate statistics for the self-similar (scale-by-scale equilibrium) transfer (inverse cascade) of uncertainty from smaller to larger scales. The Reynolds number scaling of the maximal Lyapunov exponent is contingent on the sweeping of uncertainty fluctuations by average size turbulent eddies and on the Reynolds number scaling of the uncertainty containing length scale. https://cassyni-user-files-prod.s3.amazonaws.com/8u9JxCbc3Eut5gnGUYvTWE https://cassyni.com/slides/outline/3vxvGQDHykfdtakrZxYsF3 https://cassyni.com/events/3vxvGQDHykfdtakrZxYsF3/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Wd5LeXTxnn8nEspoG4uCsG https://cassyni.com/events/3vxvGQDHykfdtakrZxYsF3?videoPreview=1 MRGM: an enhanced catalog of mouse gut microbial genomes substantially broadening taxonomic and functional landscapesnohttps://cassyni.com/events/3vxvGQDHykfdtakrZxYsF3?videoPreview=12024-10-08T00:30:00+00:00292.0Microbiome Virtual International ForumMouse gut microbiome research is pivotal for understanding the human gut microbiome, providing insights into disease modeling, host-microbe interactions, and the dietary influence on the gut microbiome. To enhance the translational value of mouse gut microbiome studies, we need detailed and high-quality catalogs of mouse gut microbial genomes. We introduce the Mouse Reference Gut Microbiome (MRGM), a comprehensive catalog with 42,245 non-redundant mouse gut bacterial genomes across 1,524 species. MRGM marks a 40% increase in the known taxonomic diversity of mouse gut microbes, capturing previously underrepresented lineages through refined genome quality assessment techniques. MRGM not only broadens the taxonomic landscape but also enriches the functional landscape of the mouse gut microbiome. Using deep learning, we have elevated the Gene Ontology annotation rate for mouse gut microbial proteins from 3.2% with orthology to 60%, marking an over 18-fold increase. MRGM supports both DNA- and marker-based taxonomic profiling by providing custom databases, surpassing previous catalogs in performance. Finally, taxonomic and functional comparisons between human and mouse gut microbiota reveal diet-driven divergences in their taxonomic composition and functional enrichment. Overall, our study highlights the value of high-quality microbial genome catalogs in advancing our understanding of the co-evolution between gut microbes and their host.https://cassyni-user-files-prod.s3.amazonaws.com/Wd5LeXTxnn8nEspoG4uCsG https://cassyni.com/slides/outline/Ar3NuyGe8ARRPPkRwQ7oPj https://cassyni.com/events/Ar3NuyGe8ARRPPkRwQ7oPj/abstract https://cassyni-user-files-prod.s3.amazonaws.com/7DBQXgKn5Z12KA7Y5oA1ci https://cassyni.com/events/Ar3NuyGe8ARRPPkRwQ7oPj?videoPreview=1 Learning to LEED: Ecolabels, Innovation, and Green Market Transformationnohttps://cassyni.com/events/Ar3NuyGe8ARRPPkRwQ7oPj?videoPreview=12022-09-20T11:00:00+00:004294.96 School of Public PolicyDelivered at the University of Georgia College of Environment & Design's Environmental Ethics Seminar Series, September 2022.https://cassyni-user-files-prod.s3.amazonaws.com/7DBQXgKn5Z12KA7Y5oA1ci https://cassyni.com/slides/outline/JFo4irVQ7Pez2kZ99gXJfX https://cassyni.com/events/JFo4irVQ7Pez2kZ99gXJfX/abstract https://cassyni-user-files-prod.s3.amazonaws.com/JdgXjmz3McT98ShjtRfiTg https://cassyni.com/events/JFo4irVQ7Pez2kZ99gXJfX?videoPreview=1 Nucleosome remodeler exclusion by histone deacetylation enforces heterochromatic silencing and epigenetic inheritancenohttps://cassyni.com/events/JFo4irVQ7Pez2kZ99gXJfX?videoPreview=12024-11-14T18:00:00+00:00743.32National Institutes of HealthHeterochromatin enforces transcriptional gene silencing and can be epigenetically inherited, but the underlying mechanisms remain unclear. Here, we show that histone deacetylation, a conserved feature of heterochromatin domains, blocks SWI/SNF subfamily remodelers involved in chromatin unraveling, thereby stabilizing modified nucleosomes that preserve gene silencing. Histone hyperacetylation, resulting from either the loss of histone deacetylase (HDAC) activity or the direct targeting of a histone acetyltransferase to heterochromatin, permits remodeler access, leading to silencing defects. The requirement for HDAC in heterochromatin silencing can be bypassed by impeding SWI/SNF activity. Highlighting the crucial role of remodelers, merely targeting SWI/SNF to heterochromatin, even in cells with functional HDAC, increases nucleosome turnover, causing defective gene silencing and compromised epigenetic inheritance. This study elucidates a fundamental mechanism whereby histone hypoacetylation, maintained by high HDAC levels in heterochromatic regions, ensures stable gene silencing and epigenetic inheritance, providing insights into genome regulatory mechanisms relevant to human diseases.https://cassyni-user-files-prod.s3.amazonaws.com/JdgXjmz3McT98ShjtRfiTg https://cassyni.com/events/V84MjtiwmTqTZ2PAmDkzcM/seminar/qa https://cassyni.com/slides/outline/V84MjtiwmTqTZ2PAmDkzcM https://cassyni.com/events/V84MjtiwmTqTZ2PAmDkzcM/abstract https://cassyni-user-files-prod.s3.amazonaws.com/AhoCzECmMS6vSvUYGGoDF4 https://cassyni.com/events/V84MjtiwmTqTZ2PAmDkzcM?videoPreview=1 High Throughput Platform for the Rapid Stretching of Brain Cellsnohttps://cassyni.com/events/V84MjtiwmTqTZ2PAmDkzcM?videoPreview=12024-10-29T03:00:00+00:003029.04The Auckland Bioengineering InstituteNew Zealand has the highest incidence of Traumatic Brain Injury (TBI) in the world. It is an injury where an external impact causes damage to the tissue of the brain and it is speculated that high incidence is a result of the interest in contact sports in the country. TBI is also the leading cause of injury-related death and disability in children across the globe and despite the large body of research carried out, there are currently no therapeutic or biological diagnostic methods for TBI. The mild form of TBI (mTBI), also known as concussions, have proven a challenge for both diagnosis even though it accounts for 90% of the cases. Several in-vitro and in-vivo models have been presented for the study of mTBI but the lack of a clear indicator for the injury shows that a large amount of research and experiments still needs to be done. There is a clear need for a tool to carry out high throughput experimentation to understand this complex injury. This study carried out in the presents the development and characterization of a High Throughput Cell Stretching Platform that utilises a Dielectric Elastomer Actuator (DEA), a form of soft actuator, to apply mechanical insults onto brain tissue.https://cassyni-user-files-prod.s3.amazonaws.com/AhoCzECmMS6vSvUYGGoDF4 https://cassyni.com/slides/outline/xQ8CJ95dHNyMQrenDNXvV https://cassyni.com/events/xQ8CJ95dHNyMQrenDNXvV/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Y8rfskpqtppAomTQg6X8Vk https://cassyni.com/events/xQ8CJ95dHNyMQrenDNXvV?videoPreview=1 Bridging physics and machine learning in material design and optimisation?nohttps://cassyni.com/events/xQ8CJ95dHNyMQrenDNXvV?videoPreview=12024-10-09T13:00:00+00:003638.12Department of Aeronautics and AstronauticsLightweight materials have become integral in diverse sectors such as transportation, energy, and healthcare. Their varied microstructures and properties present significant potential for applications from load-bearing components to multifunctional structures. However, a major challenge lies in the heterogeneous material properties and vast design space of materials, impeding effective design and optimisation. My talk will address this challenge in two parts. Firstly, I will explore mechanics-based approaches to model the failure of materials. This will encompass a wide range of scenarios, from fracture, crushing behaviour, ballistic impact to liquid-solid impact of materials. Secondly, I will showcase the application of machine learning approaches for the design of porous architected materials, focusing on optimisation strategies. By bridging mechanics and machine learning, our work aims to unlock new possibilities in material design and optimisation.https://cassyni-user-files-prod.s3.amazonaws.com/Y8rfskpqtppAomTQg6X8Vk https://cassyni.com/slides/outline/JkUHtAeoxD8orDYewneGqj https://cassyni.com/events/JkUHtAeoxD8orDYewneGqj/abstract https://cassyni-user-files-prod.s3.amazonaws.com/NvguUVGB6sFbMP6otuFaMc https://cassyni.com/events/JkUHtAeoxD8orDYewneGqj?videoPreview=1 Linking individual stress to societal and planetary healthnohttps://cassyni.com/events/JkUHtAeoxD8orDYewneGqj?videoPreview=12024-04-09T14:00:00+00:005410.96Frontiers in ScienceIn this Frontiers Forum Deep Dive session on 9 April 2024, Prof Yoram Vodovotz, Prof Julia Arciero, Prof Paul Verschure, and Dr David Katz explored links among stress, inflammation, cognition, and behavior—and how these may spread and scale, with potentially far-reaching consequences. They were joined by Prof David Almeida and Prof Jennifer Steel for a panel discussion and question and answer session. The session brought together the authors of the Frontiers in Science lead article ‘A multiscale inflammatory map: linking individual stress to societal dysfunction’ to present a radical hypothesis—inflammation connects stressors affecting individuals to impaired decision-making at scale. The authors also present insights from a mathematical model including steps for reducing stress and building resilience in individuals and societies. https://cassyni-user-files-prod.s3.amazonaws.com/NvguUVGB6sFbMP6otuFaMc https://cassyni.com/slides/outline/KF7tvrJLPfgrqz5YYDw573 https://cassyni.com/events/KF7tvrJLPfgrqz5YYDw573/abstract https://cassyni-user-files-prod.s3.amazonaws.com/SC1MpJ5Cckji5GdjFhoo1x https://cassyni.com/events/KF7tvrJLPfgrqz5YYDw573?videoPreview=1 Stomata and Global Changenohttps://cassyni.com/events/KF7tvrJLPfgrqz5YYDw573?videoPreview=12024-10-21T13:00:00+00:002639.64The New Phytologist FoundationStomata will play a critical role in determining how the world’s terrestrial vegetation responds to our changing climate. In this talk I will review some recent advances in our ability to predict stomatal behaviour under rising CO2 concentrations, rising temperature, heatwaves, and drought. Many new insights have been gained through the use of optimisation approaches to predict stomatal conductance, and I will briefly survey some of these models. I will also discuss “non-optimal” stomatal behaviour: what can we learn when stomata don’t behave as optimisation models predict?https://cassyni-user-files-prod.s3.amazonaws.com/SC1MpJ5Cckji5GdjFhoo1x https://cassyni.com/events/7tCzs8RGJ8wsZk6QBEVJ69/seminar/qa https://cassyni.com/slides/outline/7tCzs8RGJ8wsZk6QBEVJ69 https://cassyni.com/events/7tCzs8RGJ8wsZk6QBEVJ69/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Up2B2bwRdHr43reyddUdzn https://cassyni.com/events/7tCzs8RGJ8wsZk6QBEVJ69?videoPreview=1 Building Excellence: Structuring Editorial Boards for Impactnohttps://cassyni.com/events/7tCzs8RGJ8wsZk6QBEVJ69?videoPreview=12025-03-20T09:00:00+00:003316.2Topics at the heart of our communityOur Editorial Boards form the foundation for successful journals, from improving author service and decision-making to building and maintaining connections with the research community it serves. Join Ritu Dhand for insights on how to structure your editorial team to attract more high-quality submissions, and how editors can contribute to journal performance, be effective journal advocates, and maintain high standards in research integrity. https://cassyni-user-files-prod.s3.amazonaws.com/Up2B2bwRdHr43reyddUdzn https://cassyni.com/slides/outline/SACMaRMgY5SeLo57ufW1Fj https://cassyni.com/events/SACMaRMgY5SeLo57ufW1Fj/abstract https://cassyni-user-files-prod.s3.amazonaws.com/8JezeZYji8ycYqH4FBcx2J https://cassyni.com/events/SACMaRMgY5SeLo57ufW1Fj?videoPreview=1 Black Founders’ Racialized Experiences and Ventures: A Multilevel Analysisnohttps://cassyni.com/events/SACMaRMgY5SeLo57ufW1Fj?videoPreview=12024-11-20T19:00:00+00:00810.56Center for Black Entrepreneurship, Spelman CollegeThis study investigates how educational backgrounds, structural inequities, and psychosocial factors influence the mental health of Black entrepreneurs. It highlights the pervasive "hustle" culture in entrepreneurship that often discourages seeking mental health support. Analyzing survey data from 2020 to 2024, the study finds that Black entrepreneurs who attended Historically Black Colleges and Universities (HBCUs) or Minority-Serving Institutions (MSIs) report better mental well-being and a stronger commitment to equity ethics compared to those from Predominantly White Institutions (PWIs), who exhibit higher entrepreneurial identity and self-efficacy. Equity ethics refers to a principled commitment among historically marginalized people of color, particularly in STEM fields, to actively address and mitigate systemic racial and social injustices through their professional and personal actions. The research reveals that attending an HBCU/MSI significantly predicts mental well-being, surpassing structural factors like homeownership or poverty, by reducing minority status stress and enhancing entrepreneurial self-efficacy. Financial stability, through sufficient income and business profits, is linked to improved well-being, while student loan debt is detrimental to mental health. Furthermore, higher Black homeownership rates correlate with a better quality of life and mental health, whereas poverty within Black communities often spurs activism for social change. We conclude by emphasizing the need for targeted interventions, inclusive policies, and institutional support to promote both entrepreneurial success and mental well-being among Black business owners.https://cassyni-user-files-prod.s3.amazonaws.com/8JezeZYji8ycYqH4FBcx2J https://cassyni.com/slides/outline/4vLzhf414kZ4MWnMKgEJjX https://cassyni.com/events/4vLzhf414kZ4MWnMKgEJjX/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Jb3tk7J4WdwyEyza6gDYqt https://cassyni.com/events/4vLzhf414kZ4MWnMKgEJjX?videoPreview=1 Stability of time discretizations for semi-discrete high order schemes for time-dependent PDEsnohttps://cassyni.com/events/4vLzhf414kZ4MWnMKgEJjX?videoPreview=12024-12-07T17:00:00+00:002069.32JKW Symposium TeamNo abstracthttps://cassyni-user-files-prod.s3.amazonaws.com/Jb3tk7J4WdwyEyza6gDYqt https://cassyni.com/slides/outline/EoHTWhUcSYhf4Z5yYg4EEq https://cassyni.com/events/EoHTWhUcSYhf4Z5yYg4EEq/abstract https://cassyni-user-files-prod.s3.amazonaws.com/2Cu3qwaePQFA4w1oiqjGHt https://cassyni.com/events/EoHTWhUcSYhf4Z5yYg4EEq?videoPreview=1 NSD2 is a requisite subunit of the AR/FOXA1 neo-enhanceosome in promoting prostate tumorigenesisnohttps://cassyni.com/events/EoHTWhUcSYhf4Z5yYg4EEq?videoPreview=12025-03-20T18:00:00+00:003639.72Center for Cancer TrainingThe androgen receptor (AR) is a crucial protein in the prostate gland. It attaches to DNA and turns on genes that control normal prostate development. In healthy prostate cells, AR helps prevent excessive cell division and promotes normal cell functions, like producing prostatic fluid. However, in prostate cancer, AR's normal role is disrupted. It gets redirected to different parts of the DNA, leading to uncontrolled cell growth and other aggressive cancer features. But how this change happens is unknown. In this study, we found a protein called NSD2 that plays a key role in enabling AR's cancer-promoting activity. NSD2 is only expressed in prostate cancer cells, where it directly interacts with AR and helps it bind to new areas of DNA. This new binding pattern comprises over 65% of AR's binding sites in prostatic tumors. Consistently, inhibition of NSD2 rendered prostate cancer cells more normal-like and weakened hallmark cancerous characteristics. Blocking NSD2 also made cancer cells more reliant on a similar protein called NSD1. Inhibition of both NSD1 and NSD2 together caused the death of AR-dependent prostate cancer cells. Overall, this research identifies NSD2 as a new partner in AR's cancer-promoting activity. It also suggests that targeting both NSD1 and NSD2 could be a promising new treatment strategy for advanced prostate cancer. https://cassyni-user-files-prod.s3.amazonaws.com/2Cu3qwaePQFA4w1oiqjGHt https://cassyni.com/slides/outline/9roR3s1N3yAdfTNdYCMEWh https://cassyni.com/events/9roR3s1N3yAdfTNdYCMEWh/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Xb5tkHcdr9dzReoaBePoDp https://cassyni.com/events/9roR3s1N3yAdfTNdYCMEWh?videoPreview=1 Redefining Retail Catchment by Mobile Geolocation Datanohttps://cassyni.com/events/9roR3s1N3yAdfTNdYCMEWh?videoPreview=12025-02-06T12:30:00+00:001018.4Business SchoolThis study identifies actual retail catchment areas using an evidence-based method using mobile location data, moving beyond traditional isochrone-based models. By employing geofencing, geohash techniques, and analysing over 117 million data points from 1.6 million users in Auckland, we map actual catchment areas of two shopping malls. Using DBSCAN clustering and the concave hull method, we identify catchment areas based on visitors’ home-like locations, revealing significant deviations from traditional boundaries. These insights enhance understanding of consumer travel patterns and motivations, enabling more targeted retail strategies. https://cassyni-user-files-prod.s3.amazonaws.com/Xb5tkHcdr9dzReoaBePoDp https://cassyni.com/events/PCMyXaWJi3y6WqqFBfGAiy/abstract https://cassyni-user-files-prod.s3.amazonaws.com/51KjBPoK8hHpRD99mh3n5L https://cassyni.com/events/5ueCo2M3wffD2GcMRehdYR/seminar/qa https://cassyni.com/slides/outline/5ueCo2M3wffD2GcMRehdYR https://cassyni.com/events/5ueCo2M3wffD2GcMRehdYR/abstract https://cassyni-user-files-prod.s3.amazonaws.com/HJ8PY9DFwzmfUdqinefcJz https://cassyni.com/events/5ueCo2M3wffD2GcMRehdYR?videoPreview=1 Lessons learned from language learning research in the classroom and the laboratory: Potential and pitfallsnohttps://cassyni.com/events/5ueCo2M3wffD2GcMRehdYR?videoPreview=12025-03-07T00:10:00+00:002949.68Linguistics and Applied Language StudiesOver the past ten years, I have been involved in a series of research projects which have aimed to add to the empirical knowledge on teaching methodology, but in a way that reflects real classroom conditions. These projects have often focused on the differential impact of task-based language teaching compared to other more traditional approaches, and have drawn on data from classroom video observation, surveys, interviews, and eye-tracking. To evaluate impact, the studies have utilized outcome measures ranging from language output and test scores to learner motivation and self-efficacy. While these studies have provided valuable insights, I have also learned about the many challenges involved in carrying out successful classroom-based research. In this talk, I will begin with a short overview of the teaching context, including reflections on the common problems faced English language teachers in Japan. I will then discuss a selection of my research projects, both classroom- and laboratory-based. In doing so, I will discuss the limitations of each one. Limitations are sometimes relegated to a kind of ‘afterthought’ position in many papers, but they can offer powerful tips for what to avoid (or try to avoid) in future studies. https://cassyni-user-files-prod.s3.amazonaws.com/HJ8PY9DFwzmfUdqinefcJz https://cassyni.com/slides/outline/2T6yUEpNsTnZzaJnmzKg1b https://cassyni.com/events/2T6yUEpNsTnZzaJnmzKg1b/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Fvu2wA6oEdvTH7aT2ZTQHL https://cassyni.com/events/2T6yUEpNsTnZzaJnmzKg1b?videoPreview=1 A Path to High-Order CFD on Optimally Curved Meshes: Towards Coarser, but Higher-Order Meshesnohttps://cassyni.com/events/2T6yUEpNsTnZzaJnmzKg1b?videoPreview=12024-12-06T17:00:00+00:001809.72JKW Symposium TeamOptimally curved meshes are required to achieve the desired accuracy, efficiency, robustness, and convergence of high-order CFD methods. This talk stresses that much more should be done than simply curving the mesh to match the geometry and curved boundaries. First, the precise locations of high-order geometry nodes matter. Second, mesh optimization formulation must capture the strong coupling between the optimal placements of vertices and high-order geometry nodes within the computational domain; this strong coupling effectively sizes, stretches, and curves mesh elements through an interrelated process. This talk discusses several ongoing efforts to enable solution-based and metric-based optimization approaches for guiding vertex and high-order geometry node movements in finite-element meshes; all these efforts focus solely on the meshing algorithms without improving the numerics of the high-order methods. Perhaps if such mesh optimization algorithms exist, they will enable meaningful CFD simulations on coarser but higher-order meshes.https://cassyni-user-files-prod.s3.amazonaws.com/Fvu2wA6oEdvTH7aT2ZTQHL https://cassyni.com/slides/outline/DKNGVH3vXXy3Wr8pPXZMxR https://cassyni.com/events/DKNGVH3vXXy3Wr8pPXZMxR/abstract https://cassyni-user-files-prod.s3.amazonaws.com/7jcmk8rmFTu2s3v4okfaFp https://cassyni.com/events/DKNGVH3vXXy3Wr8pPXZMxR?videoPreview=1 Finding and Hiring a Research Analyst Unicornnohttps://cassyni.com/events/DKNGVH3vXXy3Wr8pPXZMxR?videoPreview=12024-03-11T23:00:00+00:002877.68Research AnalyticsAs more data analytics programs pop up, we see graduates with these degrees and certificates in our applicant pool. However, the analyst that works in higher ed administration is not like a data scientist that looks for biomarkers in genomic data or the programmer that writes in R all day. What are the skills needed for this job? What exactly is this job that we are hiring for? Should managers prioritize applicants with analytics certificates? Or is experience with sponsored projects more important? We (your presenters) don’t have perfect answers but we (the collective conference attendees) can come up with imperfect guidelines! Much of this depends on your specific institution’s characteristics and needs, but there are three things we deem absolutely necessary for an analyst to have in their skillset: an analytical mind, diverse communication skills, and quickly adapting to your institutional culture.https://cassyni-user-files-prod.s3.amazonaws.com/7jcmk8rmFTu2s3v4okfaFp https://cassyni.com/slides/outline/FncHihHYipjXsncNwDTzgM https://cassyni.com/events/FncHihHYipjXsncNwDTzgM/abstract https://cassyni-user-files-prod.s3.amazonaws.com/5Js71XGySYcebBsFXPnbUJ https://cassyni.com/events/FncHihHYipjXsncNwDTzgM?videoPreview=1 Catastrophe Risk Sharingnohttps://cassyni.com/events/FncHihHYipjXsncNwDTzgM?videoPreview=12025-01-16T04:00:00+00:001876.56Risk Sciences#### Research Insights: Runhuan Feng ***[Risk Sciences](https://www.keaipublishing.com/en/journals/risk-sciences/)*** aims to foster diverse, multidisciplinary insights in risk sciences, bridging theory and practice through a series of academic activities. This talk is part of the "Research Insights" track of this series, presenting cutting-edge findings and methodologies, offering valuable perspectives to researchers and practitioners alike. Runhuan Feng is a Chair Professor in the School of Economics and Management at Tsinghua University. He is a Fellow of the Society of Actuaries and a Chartered Enterprise Risk Analyst. Prior to joining Tsinghua, he was a tenured Professor, the State Farm Companies Foundation Endowed Professor at the University of Illinois at Urbana-Champaign, the Faculty Lead for the Finance and Insurance sector at the Discovery Partnership Institute of the University of Illinois System. He is currently serving as the Executive Editor-in-Chief for *Risk Sciences*. This speech record is from Runhuan's keynote speech for the [Risk Sciences Colloquium – International Seminar on Climate Risks](https://www.keaipublishing.com/en/journals/risk-sciences/event/risk-sciences-colloquium-international-seminar-on-climate-risks/), to be held on January 16, 2025, in Seoul, South Korea. https://cassyni-user-files-prod.s3.amazonaws.com/5Js71XGySYcebBsFXPnbUJ https://cassyni.com/events/NhiNUtrnGbR3X5JMbDyNTf/abstract https://cassyni-user-files-prod.s3.amazonaws.com/FMoQcQMwpPbW1zFA6vKdvE https://cassyni.com/events/YagTQZoH3kVNNbJP6njjbb/abstract https://cassyni-user-files-prod.s3.amazonaws.com/WSiM4bcqjmoGd4hSEnvTeW https://cassyni.com/events/HmEL24PXt1t27yb1akGNjX/abstract https://cassyni-user-files-prod.s3.amazonaws.com/o7JNx6QHDhBYnivThNMY2 https://cassyni.com/events/W7SSB9ZerTit1eppZ6q6sf/abstract https://cassyni-user-files-prod.s3.amazonaws.com/4GMKcNL2UWTiawxhvVAiYE https://cassyni.com/events/TeCQwjL2fAxLyVb36K2jsT/seminar/qa https://cassyni.com/slides/outline/TeCQwjL2fAxLyVb36K2jsT https://cassyni.com/events/TeCQwjL2fAxLyVb36K2jsT/abstract https://cassyni-user-files-prod.s3.amazonaws.com/QcK8m8HdZ4BWqDnFZKaNBY https://cassyni.com/events/TeCQwjL2fAxLyVb36K2jsT?videoPreview=1 Tunability strategies for elastic metamaterials: waveguiding, tonotopy and topological localizationnohttps://cassyni.com/events/TeCQwjL2fAxLyVb36K2jsT?videoPreview=12025-05-20T13:00:00+00:003476.44MetaMATIn this talk, I will present recent work by our group documenting two different approaches to achieve dynamic tunability in elastic metamaterials, and some of the possible applications deriving from their augmented functionality. On the one hand, photoresponsive polymers can be used to reversibly locally modify material stiffness through the application of an external optical field, allowing to introduce structural organization in a previously homogeneous material, or to modify existing structural features. On the other, appropriately modulated residual strain fields can be introduced in structures able to undergo large deformations to modify their dispersion, and therefore their wave control functionality. I will show some examples of how these two approaches enable the modulation of wave properties such as transmission, tonotopy, and topological localization in different structures, and provide some insight into potential future developments.https://cassyni-user-files-prod.s3.amazonaws.com/QcK8m8HdZ4BWqDnFZKaNBY https://cassyni.com/slides/outline/8Nur956ZYKMUCuYYB1SSBF https://cassyni.com/events/8Nur956ZYKMUCuYYB1SSBF/abstract https://cassyni-user-files-prod.s3.amazonaws.com/58oXga5utGkfzXL28X9vT8 https://cassyni.com/events/8Nur956ZYKMUCuYYB1SSBF?videoPreview=1 “Gatekeepers”, “Enablers”, or “Technicians”? The Corporate Governance Implications of Lawyer Executive Directors in Offshore Economiesnohttps://cassyni.com/events/8Nur956ZYKMUCuYYB1SSBF?videoPreview=12025-04-08T02:00:00+00:004991.04SACLThe importance associated with lawyers as directors has largely been overlooked and is understudied in the literature. The few studies there are largely restricted to considering lawyers as nonexecutive directors and typically adopt a singular deterministic institutional approach. We depart from these prior studies in adopting a theoretical model which integrates the resource-based view with its institutional counterpart and in focusing on lawyers as executive directors with operational and strategic decision making capacity. The focus of our study is on the legally dynamic and innovative offshore jurisdictional frameworks of the Caribbean which hosts the largest concentration of the biggest offshore financial centers in the world. Our findings reveal that higher proportions of lawyer-executive directors are associated with increased firm transparency in financial reporting. This is further positively moderated when jurisdictions have higher financial secrecy and seemingly paradoxically higher institutional quality. Our results yield important implications for offshore finance and associated corporate governancehttps://cassyni-user-files-prod.s3.amazonaws.com/58oXga5utGkfzXL28X9vT8 https://cassyni.com/events/CpkHZDvHVSLifZJL5fD1Kj/seminar/qa https://cassyni.com/slides/outline/CpkHZDvHVSLifZJL5fD1Kj https://cassyni.com/events/CpkHZDvHVSLifZJL5fD1Kj/abstract https://cassyni-user-files-prod.s3.amazonaws.com/6YYSGN5D6boUSFrHApvNFg https://cassyni.com/events/CpkHZDvHVSLifZJL5fD1Kj?videoPreview=1 Chiral metamaterials for multifunctional microwave devicesnohttps://cassyni.com/events/CpkHZDvHVSLifZJL5fD1Kj?videoPreview=12025-07-04T13:00:00+00:002616.04UK Metamaterials NetworkControlling the polarisation states of light forms an important part of both classical optics and microwaves. One common way to controlling polarisation is through chirality. Natural chiral materials such as quartz have weak electro-magnetic coupling and optical activity is thus a rather weak effect compared to dielectric polarisation effect. “Chiral metamaterials” have brought about a dramatic increase in chirality, opening up a wide range of opportunities for device designers. This talk will illustrate the use of chiral metamaterials for the design of microwave devices, including antennas and polarisers. Particular focus will be on the ability to impart multifunctionality by exploiting polarisation.https://cassyni-user-files-prod.s3.amazonaws.com/6YYSGN5D6boUSFrHApvNFg https://cassyni.com/events/WbfhWPUtFWP5VB64pHKfim/abstract https://cassyni-user-files-prod.s3.amazonaws.com/FVyBQyn6uRcPTuM4KkYEri https://cassyni.com/slides/outline/RfBf3Z1drvr465Nioocfzd https://cassyni.com/events/RfBf3Z1drvr465Nioocfzd/abstract https://cassyni-user-files-prod.s3.amazonaws.com/EJy9ZNPdTTAfAQSHAGcoCa https://cassyni.com/events/RfBf3Z1drvr465Nioocfzd?videoPreview=1 Social Microbiome Gradient Across the Rural-to-Urban Transition in Indonesianohttps://cassyni.com/events/RfBf3Z1drvr465Nioocfzd?videoPreview=12025-09-11T01:15:00+00:00812.32Microbiome Virtual International ForumSocial Microbiome Gradient Across the Rural-to-Urban Transition in Indonesia Safarina G. Malik1, Clarissa A. Febinia1,2, Hirzi Luqman2, Pradiptajati Kusuma1, Lidwina Priliani1, Joseph Lewis2, Prisca C. Limardi1, Desak Made Wihandani3, Gde Ngurah Indraguna Pinatih3, Herawati Sudoyo1, Alexandre Almeida4, Guy S. Jacobs2 Indonesia, a densely populated and culturally diverse country, is undergoing rapid transition from traditional to urban lifestyles, a change that may disrupt established host-microbe relationships and influence disease risk. In this study, we analysed metagenomic data from 116 individuals representing a gradient of lifestyles, including transitional hunter-gatherers, rural agriculturalists, and urban dwellers. Our analysis revealed extensive taxonomic novelty among village-specific, non-spore-forming microbes, suggesting geography-dependent transmission. We also observed a clear rural-to-urban gradient in microbiome composition, with diversity declining alongside urbanisation and complex genus-level taxonomic shifts. Notably, population of origin had a stronger association with microbiome composition than dietary patterns, highlighting the importance of non-dietary factors in shaping gut microbial communities. By including underrepresented Southeast Asian populations, this study contributes to a more globally inclusive understanding of the human gut microbiome and helps address longstanding biases toward Western urban cohorts. Affiliations 1 Genome Diversity and Disease Division, Mochtar Riady Institute for Nanotechnology, Universitas Pelita Harapan, Tangerang, Banten, Indonesia 2 Department of Archaeology, University of Cambridge, Cambridge, UK 3 Faculty of Medicine, Udayana University, Denpasar, Bali, Indonesia 4 Department of Veterinary Medicine, University of Cambridge, Cambridge, UK https://cassyni-user-files-prod.s3.amazonaws.com/EJy9ZNPdTTAfAQSHAGcoCa https://cassyni.com/events/8s97UK1nwN1fgRonSBw12M/seminar/qa https://cassyni.com/slides/outline/8s97UK1nwN1fgRonSBw12M https://cassyni.com/events/8s97UK1nwN1fgRonSBw12M/abstract https://cassyni-user-files-prod.s3.amazonaws.com/FiKxCf5XhiLbgFj4rPwAYe https://cassyni.com/events/8s97UK1nwN1fgRonSBw12M?videoPreview=1 Tropolonoids: Unveiling Natural Multi-Target Compounds with Therapeutic Potentialnohttps://cassyni.com/events/8s97UK1nwN1fgRonSBw12M?videoPreview=12025-06-20T12:00:00+00:001547.6Anti-Cancer Agents in Medicinal ChemistryTropolonoids (tropone-containing compounds) – including natural products like tropolone, hinokitiol (β-thujaplicin), colchicine, puberulic acid, and β-thujaplicinol, as well as synthetic analogs such as bistropolones – exhibit a broad spectrum of pharmacological activities. They demonstrate significant antibacterial, antifungal, antiviral, and antitumor properties, in part by inhibiting metalloenzymes and other molecular targets. For example, tropolone and hinokitiol potently inhibit zinc-dependent metalloproteases and exhibit broad antimicrobial efficacy. Dihydroxytropolones, such as β-thujaplicinol, selectively inhibit the ribonuclease H activity of HIV-1 and hepatitis B virus. Tropolonoids have demonstrated anticancer relevance through diverse mechanisms. Colchicine, a tropolone-bearing alkaloid, binds to tubulin and disrupts microtubule polymerization, thereby arresting cell division. Hinokitiol, on the other hand, induces DNA demethylation by downregulating DNA methyltransferase 1 (DNMT1) in cancer cells. These examples underscore the pharmacological significance of tropolonoids as versatile lead compounds in drug discovery, with promising applications spanning antimicrobials to anticancer agents.https://cassyni-user-files-prod.s3.amazonaws.com/FiKxCf5XhiLbgFj4rPwAYe https://cassyni.com/events/TR3n4JvMVi9vPcst2KNaH/seminar/qa https://cassyni.com/slides/outline/TR3n4JvMVi9vPcst2KNaH https://cassyni.com/events/TR3n4JvMVi9vPcst2KNaH/abstract https://cassyni-user-files-prod.s3.amazonaws.com/8FtVnf7VhKg5aC1wLPW7Vg https://cassyni.com/events/TR3n4JvMVi9vPcst2KNaH?videoPreview=1 Acoustofluidics and Metamaterialsnohttps://cassyni.com/events/TR3n4JvMVi9vPcst2KNaH?videoPreview=12025-07-01T13:00:00+00:003643.52MetaMATAcoustofluidics exploits the forces produced by ultrasonic fields to control particle motion and fluid flow. The resulting particle trapping, manipulation, and transport has a wide range of potential applications in biomedical research and beyond. There is a growing appreciation for the ways in which metamaterials can help control and shape ultrasonic acoustic fields and thus enable unique configurations of particle and flow control. My research group has, undertaken several research efforts, in collaboration with colleagues at Duke University and elsewhere, to explore new ways to link acoustofluidics and metamaterials. I will first give a short introduction to acoustic metamaterials and provide some examples of surprising technical areas in which acoustics is important. I will then provide a summary of our more recent work, highlighting the ways in which metamaterials concepts can contribute to acoustofluidic functionality.https://cassyni-user-files-prod.s3.amazonaws.com/8FtVnf7VhKg5aC1wLPW7Vg https://cassyni.com/events/3vf51UYYYnUeHL6SRiE1JD/seminar/qa https://cassyni.com/events/3vf51UYYYnUeHL6SRiE1JD/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Jr7zCyvodEaYGEqwpDwCmC https://cassyni.com/events/3vf51UYYYnUeHL6SRiE1JD?videoPreview=1 The power of multi-physics Discrete Element Method (DEM) coupled algorithms to gain insight into complex physical problemsnohttps://cassyni.com/events/3vf51UYYYnUeHL6SRiE1JD?videoPreview=12025-06-17T13:00:00+00:004742.8Granular MatterIn this talk, we present recent advances in multi-physics and multi-scale modeling from the Multi-physics Multi-scale Modelling (M3) Laboratory at Westlake University. A key focus of our research has been the development of efficient coupling algorithms integrating the Discrete Element Method (DEM) with complementary numerical approaches, including Smooth Particle Hydrodynamics (SPH), the Material Point Method (MPM), the Lattice Boltzmann Method (LBM), and the Random Walk Method (RWM). These coupled frameworks enable the simulation of complex phenomena across diverse domains, such as geotechnical, environmental, and mining engineering. A second major research direction involves tapping into these numerical methods to complement experimental observations and generate detailed data for first-principles-based upscaling, bridging grain-scale to large scale physics. We illustrate this approach through detailed case studies, including investigations into the rheology of dense suspensions, granular column collapse dynamics, and pollutant dispersion in sediment-laden flows. Finally, we outline future directions to refine these simulation algorithms, expanding their capabilities to capture a broader range of physical phenomena with higher fidelity.https://cassyni-user-files-prod.s3.amazonaws.com/Jr7zCyvodEaYGEqwpDwCmC https://cassyni.com/events/BLP8hjFR8enUmucuPb5jiD/abstract https://cassyni-user-files-prod.s3.amazonaws.com/2ZEF17Qq6fzvdSXwy9KAoY https://cassyni.com/slides/outline/7PDvStb72MH48irdH3S8jw https://cassyni.com/events/7PDvStb72MH48irdH3S8jw/abstract https://cassyni-user-files-prod.s3.amazonaws.com/5uvFf7spbJprW5U1Egv1Ui https://cassyni.com/events/7PDvStb72MH48irdH3S8jw?videoPreview=1 Disentangling the exposome’s impact on the gut microbiome and healthnohttps://cassyni.com/events/7PDvStb72MH48irdH3S8jw?videoPreview=12025-09-11T01:45:00+00:00653.28Microbiome Virtual International Forum Extensive evidence demonstrates that gut microbes can mediate how exposure to environmental agents, including nutrients, pollutants, and parasites, impacts health. Consequently, the effort to manage vertebrate health benefits from defining how different environmental agents interact with the microbiome to drive physiology. This effort, however, remains bottlenecked by the extensive scope and variation of exposure. The zebrafish model system offers an opportunity to alleviate this bottleneck and study these interactions at scale, as it affords access to large sample sizes, automated exposure and phenotyping platforms, and short generation times. In this presentation, I summarize the utility and potential for the zebrafish model system to accelerate our understanding of how the exposome and microbiome interact to impact health. I also introduce key zebrafish research analytical and experimental tools that we and others innovated to this end, including longitudinal sampling designs, high-throughput germ-free fish assays, and strategies for multi-omic data integration. Finally, I will discuss recent research we have conducted that exemplifies the utility and impact of this model system for microbiome research. This discussion will include our recent characterization of how exposure to pollutants affects zebrafish gut microbiome assembly to impact larval fish behavior, and underscores the importance of defining the environmental determinants of dysbiosis in the effort to resolve and preserve health-promoting gut microbiota. https://cassyni-user-files-prod.s3.amazonaws.com/5uvFf7spbJprW5U1Egv1Ui https://cassyni.com/events/7su9cCkWsAksxBr959Z6v9/seminar/qa https://cassyni.com/slides/outline/7su9cCkWsAksxBr959Z6v9 https://cassyni.com/events/7su9cCkWsAksxBr959Z6v9/abstract https://cassyni-user-files-prod.s3.amazonaws.com/XFKciGhtMhbzsbCj9Kw1Jv https://cassyni.com/events/7su9cCkWsAksxBr959Z6v9?videoPreview=1 Sustainable Manufacturing of optical metasurfaces for imaging, sensing and displaynohttps://cassyni.com/events/7su9cCkWsAksxBr959Z6v9?videoPreview=12025-09-16T15:30:00+00:003665.68UK Metamaterials NetworkMetamaterials and metasurfaces are novel optical components composed of nanostructure arrays. They offer the advantage of an ultracompact form factor and can image submicron objects with resolution approaching the diffraction limit of light. The scope of this imaging extends from simple microscopes to more advanced light imaging applications such as 3D sensors, LiDAR, bio-imaging, and cameras. The wavelength range of imaging is also diversifying to support various imaging applications. Metalenses operating in the UV region enable high-resolution imaging due to the short wavelength of light. In the visible light spectrum, metalenses can be used for imaging in VR/AR displays. Near-infrared metalenses have potential applications in night vision devices and endoscopes. The wavelength range extends further to include the ultrasound region, where it can be used in photoacoustic microscopy. Additionally, elastic metalenses can be applied for energy harvesting, and acoustic metalenses can be used to focus sound waves. Furthermore, metalenses can perform imaging with various functionalities. They can tune their focal length, demonstrate trichannel imaging based on spin, and even image single photons emitted from a source. While metalenses operate across various wavelengths and offer diverse functionalities for numerous imaging applications, their design is currently not scalable, making large-area designs computationally heavy and expensive. To address this, efficient computational methods like RCWA and AI/DB-based design approaches have been developed. However, even with advances in large-area design capabilities, their commercialization has been hindered by manufacturing limitations such as high cost and low throughput. To reduce the production cost of metalenses, nanoimprint lithography has been employed. To address the low refractive index of conventional imprint resins, high-refractive-index particles are incorporated, creating a one-step printable platform On the other hand, ArF photolithography has been used to overcome low throughput and produce large-area metasurfaces at wafer scale. However, due to the high manufacturing costs associated with this method, research has been conducted on mass-producing metasurfaces by using wafer-scale nanoimprint technology to replicate metasurfaces initially created through photolithography. These scalable manufacturing approaches are expected to propel metalenses beyond the research level and into practical applications.https://cassyni-user-files-prod.s3.amazonaws.com/XFKciGhtMhbzsbCj9Kw1Jv https://cassyni.com/events/4RMvHRDqnxtEvVYaRVB9PK/seminar/qa https://cassyni.com/slides/outline/4RMvHRDqnxtEvVYaRVB9PK https://cassyni.com/events/4RMvHRDqnxtEvVYaRVB9PK/abstract https://cassyni-user-files-prod.s3.amazonaws.com/JUpw6E1po2HdJpBwGZfY7Q https://cassyni.com/events/4RMvHRDqnxtEvVYaRVB9PK?videoPreview=1 Drugs Treatment Algorithms, Diabetes and Medicine Review 1600-1730nohttps://cassyni.com/events/4RMvHRDqnxtEvVYaRVB9PK?videoPreview=12025-09-18T15:00:00+00:006877.04Imperial College Renal and Transplant Centre1600 AI for Drug Treatment Algorithms - Karin Bergling Research Scientist at Renal Research Institute Innovation Hub, New York 1630 Treatment of Diabetes for People on Dialysis - Sarah Gleeson Renal Consultant, ICHNT 1700 Medicine Review in Dialysis - Cathy Pogson Renal Pharmacist, Portsmouth University Hospitalhttps://cassyni-user-files-prod.s3.amazonaws.com/JUpw6E1po2HdJpBwGZfY7Q https://cassyni.com/slides/outline/Dp3VebDLNMSsLK8LBdgL8d https://cassyni.com/events/Dp3VebDLNMSsLK8LBdgL8d/abstract https://cassyni-user-files-prod.s3.amazonaws.com/4hyXVK2Xud5B4uQPekTRnn https://cassyni.com/events/Dp3VebDLNMSsLK8LBdgL8d?videoPreview=1 'will you be able to make the call': Complex decision making in emergency care nohttps://cassyni.com/events/Dp3VebDLNMSsLK8LBdgL8d?videoPreview=12025-10-10T00:10:00+00:002937.16Linguistics and Applied Language StudiesIn this paper, I explore how medical teams do decision making in complex, high-stakes emergency care events. My interest lies in how decisions are interactionally accomplished through talk, embodied action, and material affordances. Building on completed and ongoing work, I discuss how leadership and decision making are negotiated and distributed, and how the boundaries between team members are continually redefined in practice. Turning to prehospital care, I draw on ongoing research on decision making in emergency response and ambulance dispatch. I discuss and reflect on the P.A.T.H.S. framework -Participants, Artefacts, Transition Stages, Historicity, Setting- (Angouri et al., 2024), and its affordances for capturing the dynamic and distributed nature of dispatch decision making. I close the paper with reflections on the impact of sociolinguistic research in emergency care, considering how an interactional understanding of decision making can inform training, policy, and public awareness of how to communicate with emergency teams.https://cassyni-user-files-prod.s3.amazonaws.com/4hyXVK2Xud5B4uQPekTRnn https://cassyni.com/events/AMWGKogfJ9aEJcpmXyJNbo/seminar/qa https://cassyni.com/slides/outline/AMWGKogfJ9aEJcpmXyJNbo https://cassyni.com/events/AMWGKogfJ9aEJcpmXyJNbo/abstract https://cassyni-user-files-prod.s3.amazonaws.com/7G4TA1JoX5UGuDZLd5f7Uz https://cassyni.com/events/AMWGKogfJ9aEJcpmXyJNbo?videoPreview=1 The recycling of quantum correlations triggered by general quantum measurementsnohttps://cassyni.com/events/AMWGKogfJ9aEJcpmXyJNbo?videoPreview=12025-06-27T12:00:00+00:002989.32Physics ReportsQuantum correlation and measurement are central to understanding the quantum world and underpin the development of quantum information technologies. Recent advances in generalized and non-destructive measurements have enabled the exploration of quantum correlation sharing, including its fundamental significance and potential for quantum resource recycling. In this talk， we will examine the recent key progress in sharing Bell nonlocality, quantum steering, entanglement, network nonlocality, and contextuality, emphasizing the impact of measurement strategies.https://cassyni-user-files-prod.s3.amazonaws.com/7G4TA1JoX5UGuDZLd5f7Uz https://cassyni.com/slides/outline/MDMDdQBuuorodRcvu9r6r9 https://cassyni.com/events/MDMDdQBuuorodRcvu9r6r9/abstract https://cassyni-user-files-prod.s3.amazonaws.com/WwB5FQSHTjYkKMad7Atruk https://cassyni.com/slides/outline/PgbErpRY76dHzN6VSqkja5 https://cassyni.com/events/PgbErpRY76dHzN6VSqkja5/abstract https://cassyni-user-files-prod.s3.amazonaws.com/SGTRrXy6GZMzV9KDP4gdc https://cassyni.com/events/PgbErpRY76dHzN6VSqkja5?videoPreview=1 Mechanistic Investigation of Ligand Enabled Dirhodium Catalyst Modification: Implications in Reactivity and Stereoselectivitynohttps://cassyni.com/events/PgbErpRY76dHzN6VSqkja5?videoPreview=12024-08-30T13:00:00+00:003066.4Thieme India ChemTalksDirhodium based paddlewheel catalysts display divergent and unique reactivities and are widely used in a multitude of reactions. The reactivity and selectivity can be tuned by either changing the bridging carboxylate ligands or anchoring external ligands at the axial site of the dimeric catalyst.1 However, the shortcomings of both approaches necessitate the development of other catalysts, especially for stereoselective reactions. In a few recent studies, bisphosphine complexes have provided an alternative for catalyst modification (Scheme 1).2 While newer reactivity is observed, the stereoselectivity for carbene insertion reactions still remains poor.3 Interestingly, in another class of reactions involving the arylation of ketones, a specific set of ligands (Josiphos/Garphos) have shown excellent enantioselectivity (Scheme 1b).2b Irrespective of the reaction catalyzed, a commonly proposed active species involves an axial-equitorial coordination of the bisphosphine ligand with a concomitant dissociation of a carboxylate ligand (A). However, there is no evidence in favor of the active species, and therefore, the mechanism of such transformations remains unclear. In my talk, I will focus on our group’s recent efforts using both computations and experiments to provide a mechanistic rationale behind the success of ligand modified Rh(II) catalysts. Our results show that the novel catalytic species and mechanisms proposed in literature do not hold good, and could pave the way for developing some challenging asymmetric transformations.https://cassyni-user-files-prod.s3.amazonaws.com/SGTRrXy6GZMzV9KDP4gdc https://cassyni.com/slides/outline/AqjXf3bthCERn961o9nwSu https://cassyni.com/events/AqjXf3bthCERn961o9nwSu/abstract https://cassyni-user-files-prod.s3.amazonaws.com/21Dt2wc8T5K63CHSEQbW7G https://cassyni.com/events/AqjXf3bthCERn961o9nwSu?videoPreview=1 What's new about Novelty?nohttps://cassyni.com/events/AqjXf3bthCERn961o9nwSu?videoPreview=12025-06-25T08:00:00+00:005449.52The rise of novelty indicators offers new possibilities for research and innovation policy and practice – they could transform funding allocations, research assessment process, and academic incentive structures. However, it remains unclear what they are measuring and how well they might align with researchers' views of novelty. The Metascience Novelty Indicators Challenge (MetaNIC) will address this by evaluating the effectiveness of several novelty indicators in a challenge prize format. Researchers will test their indicators against a ground truth dataset constructed from expert assessments of novelty in publications. A final prize will be awarded to the indicators that perform best relative to this dataset. While MetaNIC will serve as an early testbed for novelty indicators, it’s essential to create the space for early engagement with the future end-users of indicators – funders, publishers, researchers and higher education providers, and metascience scholars – and explore broader questions around their desirability, acceptability, and impact. Our virtual symposium will provide a deliberative space for this. It will include an overview of approaches to conceptualizing and measuring novelty, followed by structured discussions with UK and global stakeholders on key questions such as: What does an ‘implementable’ novelty indicator tool look like, beyond the minimum viable product stage? What validity and reliability tests should it pass for adopters to feel confident driving decisions based on its outputs? What other systems (e.g., interfaces, training, policies) would end-users require to ensure usability? What impacts should the ecosystem anticipate?https://cassyni-user-files-prod.s3.amazonaws.com/21Dt2wc8T5K63CHSEQbW7G https://cassyni.com/events/2So8DK9dSVbaP24XfuPUqb/seminar/qa https://cassyni.com/slides/outline/2So8DK9dSVbaP24XfuPUqb https://cassyni.com/events/2So8DK9dSVbaP24XfuPUqb/abstract https://cassyni-user-files-prod.s3.amazonaws.com/ARJZpu5N25bDgRwdnReMiW https://cassyni.com/events/2So8DK9dSVbaP24XfuPUqb?videoPreview=1 Applications and Limitations of the Use of hiPSCs in Pharmacological Researchnohttps://cassyni.com/events/2So8DK9dSVbaP24XfuPUqb?videoPreview=12025-10-15T11:00:00+00:004270.04The Pharmacological Research family of journalsThe controversies surrounding animal experimentation, its application in pharmacological research has contributed immensely to drug discovery. The fact that most animal models share similar molecular targets with humans makes them essential regulatory requirements for pre-clinical pharmacology experiments for new drugs. Consequently, millions of experimental animals have been used globally. However, with the introduction of the replacement, reduction and refinement (3Rs) ethical framework to reduce experimental animal use and their suffering, investigators are required to adhere to their principles. Although in vitro models have been proposed as alternatives to animal models, there are limitations to their use, especially those related to pharmacokinetics under culture conditions. The use of stem cells, including induced pluripotent stem cells (iPSCs) reprogrammed from adult somatic cells, have been proposed as viable and reliable alternatives to animal experimentation and in vitro modelling because they can be reprogrammed into various cells for application in pharmacological research. In this respect, human induced pluripotent stem cells (hiPSCs) can be generated from patients with specific diseases, allowing the creation of in vitro disease models that mimic the cellular and molecular characteristics of the relevant disease. hiPSC-derived cells can also be employed in screening new drug candidates for efficacy and toxicity, thus allowing for personalised drug screening, and identifying drugs that are most likely to be effective and safe for a specific patient. Furthermore, hiPSCs have potential applications in identifying and validating potential drug targets by studying the cellular and molecular mechanisms underlying disease. However, despite promising applications of hiPSCs, there are challenges in ensuring the quality, safety, and reproducibility of hiPSC-derived cells, as well as in accurately modelling complex diseases and predicting long-term drug effects. Also, there are still ethical considerations related to the source of somatic cells used for re-programming. The lecture will throw more light on successful applications of hiPSCs in pharmacological research, as well as challenges with the use of iPSCs as alternatives to animal and in vitro experiments.https://cassyni-user-files-prod.s3.amazonaws.com/ARJZpu5N25bDgRwdnReMiW https://cassyni.com/events/ApfsK82DPV2pBZx1EsFVdw/seminar/qa https://cassyni.com/slides/outline/ApfsK82DPV2pBZx1EsFVdw https://cassyni.com/events/ApfsK82DPV2pBZx1EsFVdw/abstract https://cassyni-user-files-prod.s3.amazonaws.com/WGNRRocmP7967khw361Bt https://cassyni.com/events/ApfsK82DPV2pBZx1EsFVdw?videoPreview=1 Mechanisms of cellular plasticitynohttps://cassyni.com/events/ApfsK82DPV2pBZx1EsFVdw?videoPreview=12025-09-22T14:00:00+00:003812.24Night Science InstituteThe ability of cancer cells to consistently escape therapy remains a fundamental challenge for effective treatments. A longstanding debate in the field has centered on whether resistance arises primarily through genetic reprogramming or through cellular plasticity. Emerging evidence increasingly supports a “plasticity-first” model in which adaptive cellular states initially arise through a physiological response to environmental stress and are subsequently stabilized and extended by both epigenetic memory and genetic mutations. In this talk I will describe evidence that cancer cells can engage in an exploratory reprogramming of gene regulation as a means of adapting toward progressively resistant states. I will also offer my lab's perspective on the mechanisms that drive this adaptive gene regulation, including stress-induced feedback responses, combinatorial regulatory networks, and systems for maintaining and recalling adaptive states. Finally, I will highlight the broader relevance of these mechanisms – extending beyond cancer to contexts such as inflammation and neurobiology – and the insights they offer into the origin and evolution of novel gene regulatory programs.https://cassyni-user-files-prod.s3.amazonaws.com/WGNRRocmP7967khw361Bt https://cassyni.com/events/Mi2SniMKkdLdStcShFy52M/abstract https://cassyni-user-files-prod.s3.amazonaws.com/FgUncZ9C1gkKE1BN6NoodY https://cassyni.com/slides/outline/x6GwNULCKByjrcPg8SLkV https://cassyni.com/events/x6GwNULCKByjrcPg8SLkV/abstract https://cassyni-user-files-prod.s3.amazonaws.com/5Dibeufwnu8WcpfKs5Enri https://cassyni.com/events/x6GwNULCKByjrcPg8SLkV?videoPreview=1 Metamaterials for sports applicationsnohttps://cassyni.com/events/x6GwNULCKByjrcPg8SLkV?videoPreview=12022-10-20T12:00:00+00:003270.32UK Metamaterials NetworkThis seminar addresses the integration of metamaterials within sports engineering to enhance athletic performance, injury prevention, and participation. Sports engineering applies physics, mathematics, and technology to solve sport-specific challenges, with rapid technology adoption making it an ideal testbed for novel materials such as auxetics. Experimental mechanics, high-speed imaging, and modeling techniques are employed to characterize sports equipment and protective gear, including wrist protectors, rugby padding, running shoes, and tennis rackets. Notably, auxetic materials—characterized by a negative Poisson’s ratio—demonstrate enhanced indentation resistance, improved vibration damping, and synclastic curvature, offering potential for lighter, more flexible, and better-fitting protective equipment. Methods for producing auxetic foams involve thermo-mechanical compression and steam treatment to induce re-entrant cellular structures, with digital image correlation used to validate mechanical behavior under dynamic loading. Additive manufacturing enables precise control of auxetic structures, facilitating tailored mechanical properties and gradient designs. Applications extend to prosthetic socket liners with adaptive auxetic materials that conform to user morphology, and commercial sports products such as tennis rackets and running shoes incorporating auxetic-inspired structures. Ongoing collaborations with industry and regulatory bodies aim to certify and implement these materials in sports equipment, while educational initiatives promote public engagement with advanced materials science. The convergence of metamaterials and sports engineering presents significant opportunities for innovation in protective gear, performance equipment, and adaptive wearable technologies, with future work focusing on scalable manufacturing and smart, responsive material systems.https://cassyni-user-files-prod.s3.amazonaws.com/5Dibeufwnu8WcpfKs5Enri https://cassyni.com/slides/outline/EJJP6TeTAm2qdXrCeV14td https://cassyni.com/events/EJJP6TeTAm2qdXrCeV14td/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Vb8UNXST3ZhXrBnnki267x https://cassyni.com/events/EJJP6TeTAm2qdXrCeV14td?videoPreview=1 Digitization initiatives as a foundation for accelerating transition to sustainable future of energynohttps://cassyni.com/events/EJJP6TeTAm2qdXrCeV14td?videoPreview=12024-10-16T23:00:00+00:004613.04Business SchoolThe utilities market, involving both energy and water, is undergoing significant disruption and requires increased digital transformation. The energy sector, driven by technology innovations and regulatory pressures continues to make major shifts towards a net-zero future. These shifts are characterized by significant investment in diverse renewable energy sources along with initiatives that aim to enhance power generation, optimize consumption, improve customer experience, and reduce total cost of ownership. Increasingly, the water industry faces pressing challenges around access to clean water for a growing population, and the need to mitigate environmental impact and risk from inefficient water and wastewater management. At the heart of this disruption is technology, which is an essential catalyst for change. As the utilities market continues to evolve, technology plays a vital role in driving sustainable growth, environmental and sustainable stewardship, and improved services for consumers and generators alike. In the session, Dr Zeev Berkowitz, Chief Operating Officer at Gentrack Limited will describe the disruption in the markets and the way Gentrack’s technology enables utilities sectors to unlock ongoing benefits of efficient and effective systems, leading to a more sustainable future for all.https://cassyni-user-files-prod.s3.amazonaws.com/Vb8UNXST3ZhXrBnnki267x https://cassyni.com/events/JERZ81EyNiGNpdAsVK3fgZ/seminar/qa https://cassyni.com/slides/outline/JERZ81EyNiGNpdAsVK3fgZ https://cassyni.com/events/JERZ81EyNiGNpdAsVK3fgZ/abstract https://cassyni-user-files-prod.s3.amazonaws.com/7hTWZX9JvynF5DkcG4U6Dk https://cassyni.com/events/JERZ81EyNiGNpdAsVK3fgZ?videoPreview=1 Visual Data Compression in the AI Eranohttps://cassyni.com/events/JERZ81EyNiGNpdAsVK3fgZ?videoPreview=12025-09-04T13:00:00+00:003620.04Journal on Image and Video ProcessingThis talk will delve into the evolution of visual data compression in recent years, spotlighting how compression techniques and AI models are integrated together. Traditionally, image and video codecs such as JPEG, HEVC, and AV1 are designed primarily for accurate pixel reconstruction. However, the advancement of AI technologies has begun transforming these frameworks to meet modern application demands. This talk will discuss such shift through three lenses: - Compression with AI: enhance the coding performance of compression algorithms with AI techniques. I will discuss the use of generative AI models, particularly variational autoencoders in lossy image compression, and their resemblance to traditional coding concepts such as transform coding, and wavelet transform. - Compression for AI: design compression systems for AI-based recognition and processing (as opposed to human viewing only). I will showcase potential real-world applications of coding for machines and present several recent methods targeting mobile-cloud systems. - Compression of AI: efficient compression of AI models to reduce computational costs. I will present pruning and quantization methods to address the challenges of compressing neural network-based codecs.https://cassyni-user-files-prod.s3.amazonaws.com/7hTWZX9JvynF5DkcG4U6Dk https://cassyni.com/slides/outline/XZvsNTi9E5DLhqUTeYBzMK https://cassyni.com/events/XZvsNTi9E5DLhqUTeYBzMK/abstract https://cassyni-user-files-prod.s3.amazonaws.com/PQoreFJNyk65DcV6cps3sc https://cassyni.com/events/XZvsNTi9E5DLhqUTeYBzMK?videoPreview=1 Recovery of neurological and musculoskeletal conditions using health technologies incorporating multiscale biophysical digital twinsnohttps://cassyni.com/events/XZvsNTi9E5DLhqUTeYBzMK?videoPreview=12025-09-09T04:00:00+00:004442.44The Auckland Bioengineering InstituteThe effective management of neurological and musculoskeletal conditions necessitates interventions that optimise the functional biophysical environment, or niche, of neural and musculoskeletal tissues during daily activities, rehabilitation, and training. Advanced health and medical technologies can help create niches to recover sensorimotor control, tissue motion, loading, biology, and morphology. To understand and model these niches, our research combines multiscale experimental methods to create multiscale biophysical human digital twins of an individual’s neuro-muscle-skeletal-joint system. These are personalised rigid body and finite element computational models, which can even work in real-time by optimised mathematics and AI/ML methods. Such human digital twins are linked to digital twins of health and medical devices (e.g., implants, neurorehabilitation equipment, smart garments) i.e., HealthTech embedded with digital twins. These technologies can assist in designing surgeries, implants, and surgical instruments to reduce surgery times and improve outcomes. They can aid neurological condition recovery, where users intuitively control neurorehabilitation equipment through brain-computer interfaces, gamified virtual reality, and robotics with electrical stimulation of the spine and muscles to assist with movement. Finally, laboratory-quality measurements and digital twins can be performed outside the lab using AI, wearable sensors or computer vision pose estimation, enabling training in clinics, gyms, or fields, for health conditions such as Achilles tendinopathy and hip joint osteoarthritis. Such advancements in health technologies pave the way for managing neurological and musculoskeletal conditions in the future.https://cassyni-user-files-prod.s3.amazonaws.com/PQoreFJNyk65DcV6cps3sc https://cassyni.com/slides/outline/9MpLddBCnBVpES8re1J5AV https://cassyni.com/events/9MpLddBCnBVpES8re1J5AV/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Gmj97VQtaRUpg52C6Z3mD8 https://cassyni.com/events/9MpLddBCnBVpES8re1J5AV?videoPreview=1 Technology Procurement Contracts: The Forgotten Legal Conversation that underpins a Successful IT Implementationnohttps://cassyni.com/events/9MpLddBCnBVpES8re1J5AV?videoPreview=12021-08-24T23:00:00+00:003614.8Business SchoolThe successful implementation of information technology solutions is fundamentally underpinned by robust technology procurement contracts, a frequently overlooked legal dimension. This analysis delineates essential elements of a comprehensive procurement process, stressing the early engagement of key stakeholders from both customer (e.g., business, IT, legal, C-suite) and supplier (e.g., sales, commercial, legal, management) perspectives. Emphasis is placed on understanding customer procurement plans (RFI, RFP, RFT), managing supplier assumptions, fostering competitive tension, and establishing clear project constraints regarding budget, timing, and quality. Common contract types are explored, including software licenses (non-exclusive rights, user and hardware restrictions, prohibited acts) and Software-as-a-Service (SaaS) agreements, which are typically subscription-based, cloud-delivered, and often bundle support. Implementation agreements, crucial for high-value and complex projects like ERP or CRM, detail installation, configuration, customisation, user requirements, specifications, and project timetables. Other critical documents include Service Level Agreements (SLAs), which define performance metrics such as system availability (e.g., 99.9%) and priority issue resolution, and escrow arrangements for source code access under specific conditions. Key negotiation points span fee structures (initial, recurring, staged payments often including a warranty holdback period of 30 days to a year), comprehensive data security and privacy provisions (aligned with acts like the Privacy Act 2020), license terms, and termination rights. Warranties, encompassing software functionality, non-infringement of third-party intellectual property, and freedom from malware, are also vital, as are limitations and exclusions of liability, which frequently carve out critical areas such as IP infringement or data loss. This detailed contractual framework is essential for mitigating risks, protecting intellectual property, and ensuring the successful delivery and ongoing functionality of IT projects.https://cassyni-user-files-prod.s3.amazonaws.com/Gmj97VQtaRUpg52C6Z3mD8 https://cassyni.com/events/QAERnqXA3ZqH3FzTrAmm5P/seminar/qa https://cassyni.com/slides/outline/QAERnqXA3ZqH3FzTrAmm5P https://cassyni.com/events/QAERnqXA3ZqH3FzTrAmm5P/abstract https://cassyni-user-files-prod.s3.amazonaws.com/YBgQEGrFRQyeJ8wCjhy9re https://cassyni.com/events/QAERnqXA3ZqH3FzTrAmm5P?videoPreview=1 Inflammatory cell death and anti-tumor immunitynohttps://cassyni.com/events/QAERnqXA3ZqH3FzTrAmm5P?videoPreview=12025-10-14T15:00:00+00:005637.04Research Seminars by Springer NatureDifferent types of regulated cell death, including ferroptosis, necroptosis, and pyroptosis, can elicit an immune response. In this webinar, our speakers will introduce the concept of inflammatory/immunogenic cell death and discuss its implications for cancer immunity and immunotherapy. The presentations will be followed by a panel discussion and Q&A session. The webinar will be hosted by Nature Cancer and Nature Communications editors.https://cassyni-user-files-prod.s3.amazonaws.com/YBgQEGrFRQyeJ8wCjhy9re https://cassyni.com/slides/outline/KEp3fvdaxhVsERqHS8zsw3 https://cassyni.com/events/KEp3fvdaxhVsERqHS8zsw3/abstract https://cassyni-user-files-prod.s3.amazonaws.com/UhHwGqTPYy4Jf96c99dSjx https://cassyni.com/events/KEp3fvdaxhVsERqHS8zsw3?videoPreview=1 Hyperbolic wave attractornohttps://cassyni.com/events/KEp3fvdaxhVsERqHS8zsw3?videoPreview=12025-06-17T05:00:00+00:001916.0ETOPIMChaos theory is at the basis of many breakthroughs of the last century, ranging from the understanding of climate change to quantum physics and astronomy. In the context of wave physics, irregularly shaped cavities are known to feature a chaotic response, with rich implications for their dynamics and technological opportunities 1. At the other extreme, hyperbolic media are characterized by extreme optical anisotropy, supporting highly directional propagation of ray-like waves 2. Here, we study the intriguing dynamics of oddly-shaped cavities made of hyperbolic media. By leveraging the interplay between the directionality of hyperbolic wave propagation and the broken symmetry of oddly-shaped cavities, we demonstrate the emergence of a broadband, scale-independent and inherently stable wave pattern (Fig. 1a), which we dub a hyperbolic wave attractor given its analogy with limit cycles in nonlinear dynamical systems 3 , and internal wave attractors occurring in stratified fluids 4. We demonstrate the unique features of this wave phenomenon using linear elastodynamic waves in a pillared metasurface 5 (Fig. 1b). Notably, we establish a chiral convergence in the attractor formation wherever the source location (Fig. 1c), and the existence of continua of wave patterns with topological features across broad frequency ranges, well-suited to realize a proof-of-concept phonon spectrometer with some robustness to defects. Our findings connect hyperbolic media with attractor physics leveraging tailored broken symmetries at the material and cavity level, with implications for dynamical systems, particle trapping, sensing and topological wave steering, and with potential applications into emerging phononic, photonic and polaritonic platforms.https://cassyni-user-files-prod.s3.amazonaws.com/UhHwGqTPYy4Jf96c99dSjx https://cassyni.com/slides/outline/VcRjeHDcBK8Hkw8RTEwmcZ https://cassyni.com/events/VcRjeHDcBK8Hkw8RTEwmcZ/abstract https://cassyni-user-files-prod.s3.amazonaws.com/F9HjfZ7MtWkpZPRFYSaub4 https://cassyni.com/events/VcRjeHDcBK8Hkw8RTEwmcZ?videoPreview=1 Moire platforms beyond TMDs and graphenenohttps://cassyni.com/events/VcRjeHDcBK8Hkw8RTEwmcZ?videoPreview=12025-06-19T03:00:00+00:003641.48ETOPIMMoiré systems, formed by stacking and twisting two-dimensional materials, offer a versatile platform for engineering novel quantum phases by tuning electronic interactions and band structures. This analysis explores the realization of diverse interacting Hamiltonians beyond the well-studied graphene and transition metal dichalcogenide (TMD) moiré systems, emphasizing the potential to simulate complex many-body physics. The approach involves manipulating moiré superlattices through controlled twist angles in homo- and heterobilayers, enabling drastic bandwidth reduction and the emergence of flat bands with enhanced electron correlations. Theoretical frameworks incorporate topological band theory and Wannier orbital constructions, revealing that flat bands in twisted bilayer graphene exhibit nontrivial topology obstructing full localization, with a decomposition into heavy “f-electron”–like localized states and dispersive “c-electron” states. Projection of screened Coulomb interactions onto these localized orbitals yields effective Hubbard models, capturing Mott insulating and superconducting phases observed experimentally. Advanced spectroscopic techniques combining scanning tunneling microscopy (STM) with momentum resolution confirm interaction-driven band reconstructions consistent with dynamical mean-field theory predictions. Extending beyond graphene, the study highlights the rich phase space accessible by twisting materials with different band extrema (e.g., M points) and symmetries, leading to one-dimensional coupled chain models with complex correlated states. This work underscores moiré platforms as tunable quantum simulators for strongly correlated and topological matter, with implications for discovering new states and guiding material design in two-dimensional heterostructures.https://cassyni-user-files-prod.s3.amazonaws.com/F9HjfZ7MtWkpZPRFYSaub4 https://cassyni.com/slides/outline/Ud8XYuvZJQ296BJRMGUSof https://cassyni.com/events/Ud8XYuvZJQ296BJRMGUSof/abstract https://cassyni-user-files-prod.s3.amazonaws.com/GmB4WwdceBCwJiLuUqMRHY https://cassyni.com/events/Ud8XYuvZJQ296BJRMGUSof?videoPreview=1 Matching simulation with experiment - near-field mapping of metamaterials in the visible to terahertz rangenohttps://cassyni.com/events/Ud8XYuvZJQ296BJRMGUSof?videoPreview=12025-10-10T13:00:00+00:001849.04UK Metamaterials NetworkThe principle of metamaterial design stems around designing arrays of sub-wavelength elements, whose response gives rise to macroscale system properties. The properties of these sub-wavelength elements, their geometry and their distribution all influence the large-scale behaviour. The design of these meta-atoms can take place on nanoscale length scales and involves calculating the near-field response of the structures, which is transformed to give the far-field response. Experimental verification mainly takes place in the far-field and direct measurement of the near-field response of meta-components is lacking. In this talk, we introduce scattering-type scanning near-field optical microscopy (s-SNOM) as a powerful tool for measuring the near-field response of metamaterials and showcase the open-access facilities at Manchester open to the UK metamaterial community. https://cassyni-user-files-prod.s3.amazonaws.com/GmB4WwdceBCwJiLuUqMRHY https://cassyni.com/slides/outline/5Qf8NnWtfszPbFNaXTeUCD https://cassyni.com/events/5Qf8NnWtfszPbFNaXTeUCD/abstract https://cassyni-user-files-prod.s3.amazonaws.com/FyQPWxdhhuk8BBAFBu776v https://cassyni.com/events/5Qf8NnWtfszPbFNaXTeUCD?videoPreview=1 Bark beetle—fungi symbioses reshape nutrient dynamics, fungal decomposer succession, and decay rates in ponderosa pinenohttps://cassyni.com/events/5Qf8NnWtfszPbFNaXTeUCD?videoPreview=12025-07-09T12:00:00+00:00857.08NoneBark beetles introduce fungi into trees that redistribute nutrients and influence beetle fitness, likely altering fungal community assembly and wood decomposition. Most research examines beetles with obligate fungal partners, but little is known about species associating with loose, variable fungal consortia. We studied the red turpentine beetle, which lacks specific partners, to test how its fungal consortium affects tree nutrient dynamics, downstream fungal communities, and wood decay. We used beetle-colonized and uncolonized control logs to track fungal composition and changes in carbon (C), nitrogen (N), and phosphorus (P) in sapwood and phloem—from before colonization through brood emergence. Endophytic fungi were replaced in both treatments, but by different communities, and and logs with beetle-colonized phloem lost more sapwood density. Phloem, naturally low in N, became enriched in N, C, and P when colonized by beetle fungi, while sapwood N declined. Isotope tracing confirmed fungal transfer of nutrients from sapwood to phloem and into beetles. Our results demonstrate that even beetles without obligate partners benefit from nutrient provisioning by both consortium and non-consortium fungi, though consortium fungi are superior provisioners. Finally, beetle-associated fungi reshaped decomposer communities, with potential consequences for nutrient cycling and carbon storage in forest ecosystems. https://cassyni-user-files-prod.s3.amazonaws.com/FyQPWxdhhuk8BBAFBu776v https://cassyni.com/events/S8pqya7FoQ438yGhD8dhVw/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Ja6EvAzoiLmkYCo6gNf56E https://cassyni.com/events/5PbU2rwDNAnmzypQw1iMcR/seminar/qa https://cassyni.com/slides/outline/5PbU2rwDNAnmzypQw1iMcR https://cassyni.com/events/5PbU2rwDNAnmzypQw1iMcR/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Ggj1maf55VT6q1mB1ZCVBt https://cassyni.com/events/5PbU2rwDNAnmzypQw1iMcR?videoPreview=1 Settling aerodynamics is a driver of symmetry in deciduous tree leavesnohttps://cassyni.com/events/5PbU2rwDNAnmzypQw1iMcR?videoPreview=12025-10-22T14:00:00+00:003090.8Royal Society PublishingLeaves shed by deciduous trees contain 40% of the annually sequestered carbon and include nutrients vital to the expansion and health of forest ecosystems. To achieve this, leaves must fall quickly to land near the parent tree—otherwise, they are lost to the wind, like pollen or gliding seeds. However, the link between leaf shape and sedimentation speed remains unclear. To gauge the relative performance of extant leaves, we developed an automated sedimentation apparatus capable of performing approximately 100 free-fall experiments per day on biomimetic paper leaves. The majority of 25 representative leaves settle at rates similar to our control (a circular disc). Strikingly, the Arabidopsis mutant asymmetric leaves1 (as1) fell 15% slower than the wild-type. Applying the as1-digital mutation to deciduous tree leaves revealed a similar speed reduction. Data correlating shape and settling across a broad range of natural, mutated and artificial leaves support the fast-leaf hypothesis: deciduous leaves are symmetric and relatively unlobed partly because this maximizes their settling speed and concomitant nutrient retention.https://cassyni-user-files-prod.s3.amazonaws.com/Ggj1maf55VT6q1mB1ZCVBt https://cassyni.com/slides/outline/Qeuex9gZtPK6riyyeGtjFb https://cassyni.com/events/Qeuex9gZtPK6riyyeGtjFb/abstract https://cassyni-user-files-prod.s3.amazonaws.com/LcD78unmaACwkUyBn3RWgv https://cassyni.com/events/Qeuex9gZtPK6riyyeGtjFb?videoPreview=1 An ecophysiological basis for the assembly of Australian rainforest tree communitiesnohttps://cassyni.com/events/Qeuex9gZtPK6riyyeGtjFb?videoPreview=12025-08-05T08:45:00+00:00813.44NoneUnderstanding the role of climate in the assembly of rainforest tree communities is informative for predicting how future climates will impact species and communities. We surveyed rainforest tree communities across the Australian subtropics (spanning 600 to 2500 mm rainfall year$^{−1}$) and measured functional traits on 285 (91%) of all recorded species. We used principal component analysis to create axes approximating species' hydraulic strategies, leaf economics and stature and included these as predictors in joint species distribution models, along with traits describing dispersal ability and leaf phenology. Hydraulic strategy and leaf phenology strongly modulated species' occurrence trends along the moisture availability gradient, while stature and leaf economics modulated species' responses to minimum temperature and soil variables, respectively. Overall, we quantify the occurrence trends of almost half of Australia's subtropical rainforest tree species based on their functional traits, providing a general foundation for prediction under ongoing climate change.https://cassyni-user-files-prod.s3.amazonaws.com/LcD78unmaACwkUyBn3RWgv https://cassyni.com/events/Y4dieQPSUFcwMJWSc9kTfb/abstract https://cassyni-user-files-prod.s3.amazonaws.com/FBXGGPu533YuAmSoosLfwt https://cassyni.com/slides/outline/PAzTvjFsyNaVK22pV8PryB https://cassyni.com/events/PAzTvjFsyNaVK22pV8PryB/abstract https://cassyni-user-files-prod.s3.amazonaws.com/BXrRah5CytMygVZUz1YSSz https://cassyni.com/events/PAzTvjFsyNaVK22pV8PryB?videoPreview=1 The turbulence problem -- the wrong control parameter and one of the Martiansnohttps://cassyni.com/events/PAzTvjFsyNaVK22pV8PryB?videoPreview=12025-12-10T09:00:00+00:004030.04The Edinburgh Fluid Dynamics Group (EFDG)While the issue of what drives the transition to turbulence in pressure-driven pipe flow appears to be a basic, down-to-earth problem, somehow things got out of control.https://cassyni-user-files-prod.s3.amazonaws.com/BXrRah5CytMygVZUz1YSSz https://cassyni.com/slides/outline/GFoWpe8zDX7taSCEqnFHdP https://cassyni.com/events/GFoWpe8zDX7taSCEqnFHdP/abstract https://cassyni-user-files-prod.s3.amazonaws.com/HDe45G3P9B2eGzM91VUQZk https://cassyni.com/events/GFoWpe8zDX7taSCEqnFHdP?videoPreview=1 Shaping Georgia's Energy Future: Climate Solutions That Go Beyond Carbonnohttps://cassyni.com/events/GFoWpe8zDX7taSCEqnFHdP?videoPreview=12022-02-23T09:00:00+00:001324.4 School of Public PolicySubnational entities are recognizing the need to systematically examine options for reducing their carbon footprints. However, few robust and comprehensive analyses are available that lay out how US states and regions can most effectively contribute. Our ongoing collaborative research program, “Drawdown Georgia”, involves (1) understanding Georgia’s baseline carbon footprint and trends, (2) identifying the universe of Georgia-specific carbon-reduction solutions that could be impactful by 2030, (3) estimating the greenhouse gas reduction potential of these high-impact 2030 solutions for Georgia, and (4) estimating associated costs and benefits while also considering how the solutions might impact societal priorities, such as economic development opportunities, public health, environmental benefits, and equity. We began by examining the global solutions identified by Project Drawdown. The resulting 20 high-impact 2030 solutions provide a strategy for reducing Georgia’s carbon footprint in the next decade using market-ready technologies and practices and including negative emission solutions. https://cassyni-user-files-prod.s3.amazonaws.com/HDe45G3P9B2eGzM91VUQZk https://cassyni.com/slides/outline/BKKUMofjpwasBLUtqJYHuF https://cassyni.com/events/BKKUMofjpwasBLUtqJYHuF/abstract https://cassyni-user-files-prod.s3.amazonaws.com/R7gZTTXYzQ4wLjA8sM7w6v https://cassyni.com/events/BKKUMofjpwasBLUtqJYHuF?videoPreview=1 Tackling unproven cell-based therapies and the impact of COVID-19nohttps://cassyni.com/events/BKKUMofjpwasBLUtqJYHuF?videoPreview=12021-08-19T08:00:00+00:00448.08 School of Public PolicyThe proliferation of unproven cell-based therapies, particularly in the United States, has intensified regulatory and ethical challenges, with a notable concentration in orthopedics. Despite the US Food and Drug Administration (FDA) ending a period of regulatory discretion and clarifying guidelines that require clinics to initiate formal clinical trials, many providers continue to operate outside these frameworks, often in defiance of regulatory expectations. The COVID-19 pandemic further complicated this landscape by amplifying health misinformation and enabling some clinics to market unsubstantiated claims about cell therapies’ efficacy against COVID-19, frequently without robust clinical evidence. Although the FDA increased enforcement actions during the pandemic, issuing numerous warning letters against unsupported therapeutic claims, resource constraints and competing priorities limit regulatory capacity. Additionally, the emergence of speculative cell banking services—offering storage of various cell types for potential future use—raises concerns about premature commercialization and misleading marketing that may exploit patients. These services often lack meaningful engagement with regulatory processes critical to ensuring product safety and efficacy, mirroring early issues seen in the unproven therapy sector. Ongoing monitoring and regulatory vigilance are essential to safeguard patient interests, promote evidence-based development, and guide the responsible evolution of cell-based therapies and associated services.https://cassyni-user-files-prod.s3.amazonaws.com/R7gZTTXYzQ4wLjA8sM7w6v https://cassyni.com/slides/outline/MgxnSnmeSv91rKUS8yRdDP https://cassyni.com/events/MgxnSnmeSv91rKUS8yRdDP/abstract https://cassyni-user-files-prod.s3.amazonaws.com/CiHBj5BD2VKeTpWZxQbwLS https://cassyni.com/events/MgxnSnmeSv91rKUS8yRdDP?videoPreview=1 Where are we headed with a learner who struggles? Launching remediation pathwaysnohttps://cassyni.com/events/MgxnSnmeSv91rKUS8yRdDP?videoPreview=12024-10-23T08:00:00+00:003635.28AAMCWhat is the plan for learners who struggle in medical school? This question is frequently asked and difficult to answer across health professions education. While remediation is essential to assuring the success of students who struggle, it remains a stigmatized and perplexing area of medical school curricula. Join us as we examine two important cutting-edge concepts in remediation with practical examples. First, we will consider how remediation pathways can and should influence medical school curriculum and systems. We will then consider the role of “compassionate off-ramps” for situations where remediation cannot be successfully achieved. Future directions for impactful remediation systems will highlight what can be achieved as we strive toward optimizing curricula in competency-based medical education. This webinar is part of the Building Better Curriculum Series, hosted by the AAMC. For more information on the complete series, see the [series webpage](https://www.aamc.org/about-us/mission-areas/medical-education/curriculum-resources/establish-your-ci/webinars).  https://cassyni-user-files-prod.s3.amazonaws.com/CiHBj5BD2VKeTpWZxQbwLS https://cassyni.com/events/R9at7TqyjCoFQjK3r6FoPj/seminar/qa https://cassyni.com/slides/outline/R9at7TqyjCoFQjK3r6FoPj https://cassyni.com/events/R9at7TqyjCoFQjK3r6FoPj/abstract https://cassyni-user-files-prod.s3.amazonaws.com/EUjeUmr4QbKxuXS88zHRCJ https://cassyni.com/events/R9at7TqyjCoFQjK3r6FoPj?videoPreview=1 The World Logic Day and other LUA projects for 2026 nohttps://cassyni.com/events/R9at7TqyjCoFQjK3r6FoPj?videoPreview=12026-01-14T15:00:00+00:005033.6Logica UniversalisWe will remind the launch of the World Logic Day on January 14, 2019 by the Logica Universalis Association, its recognition the same year by UNESCO thanks to the support of the Brazilian Ambassador at UNESCO, Maria Edileuza Fontenele Reis. We will discuss the evolution of this project and its connection with other LUA projects such as the World Logic Prizes Contest. We will then present the various events that will be organized by LUA in 2026.https://cassyni-user-files-prod.s3.amazonaws.com/EUjeUmr4QbKxuXS88zHRCJ https://cassyni.com/slides/outline/LhfaMRUba12sBZeS2zxJQV https://cassyni.com/events/LhfaMRUba12sBZeS2zxJQV/abstract https://cassyni-user-files-prod.s3.amazonaws.com/4GMQ2EygECQoHE2wZUkdhQ https://cassyni.com/events/LhfaMRUba12sBZeS2zxJQV?videoPreview=1 2024 AAAS Annual Meeting Closing Plenary Panelnohttps://cassyni.com/events/LhfaMRUba12sBZeS2zxJQV?videoPreview=12024-02-21T09:00:00+00:004543.68 School of Public PolicyThe 2024 AAAS Annual Meeting Closing Plenary Panel convened leading figures in science, academia, and policy to address critical themes surrounding the identity of scientists, research integrity, institutional challenges, and the imperative of dismantling barriers within the scientific enterprise. Panelists debated the definition of a scientist, contrasting narrower views that restrict the term to active research practitioners with broader perspectives recognizing science as a universal, inquisitive pursuit embedded in diverse disciplines including social sciences. The discussion emphasized the importance of inclusivity and the role of scientific literacy across society. On research integrity, the panel acknowledged persistent issues such as data manipulation and systemic pressures favoring positive results, while affirming that trust in science remains warranted due to its demonstrable societal benefits. Institutional critiques highlighted outdated academic structures, particularly the protracted and inflexible nature of graduate training, and the inadequate compensation and mentorship of trainees, calling for fundamental reforms to better align education with evolving career pathways. The session underscored the necessity of transparent communication and public engagement to enhance trust and understanding. Concluding remarks focused on overcoming “walls” that impede interdisciplinary collaboration and science-informed policymaking, advocating for integrated ecosystems that unite scientists, policymakers, and communicators. The forthcoming 2025 AAAS meeting in Boston will build on these themes under the banner “Science Shaping Tomorrow,” emphasizing the collaborative role of science in addressing global challenges through trust and partnership.https://cassyni-user-files-prod.s3.amazonaws.com/4GMQ2EygECQoHE2wZUkdhQ https://cassyni.com/slides/outline/V6gr93UX2nSrLtzu6rHMdP https://cassyni.com/events/V6gr93UX2nSrLtzu6rHMdP/abstract https://cassyni-user-files-prod.s3.amazonaws.com/UwhzZknsPhMhJPCFpGH1pi https://cassyni.com/events/V6gr93UX2nSrLtzu6rHMdP?videoPreview=1 The Impact of AI on Businessnohttps://cassyni.com/events/V6gr93UX2nSrLtzu6rHMdP?videoPreview=12023-08-16T08:00:00+00:003042.2 School of Public PolicyThe seminar explores the multifaceted impact of artificial intelligence (AI) on business, emphasizing both its transformative potential and associated challenges. The discussion highlights generative AI’s recent advancements, such as rapid content creation and synthetic media, which mark a significant departure from earlier AI applications. These capabilities enable unprecedented scalability in creativity and operational efficiency, exemplified by platforms like Uber that leverage AI to optimize resource allocation and service delivery at scale. Organizational behavior perspectives underscore AI’s role as a partner in augmenting human work, facilitating upskilling, streamlining processes, and creating new job categories, while also acknowledging workforce anxieties about displacement. Case studies in healthcare illustrate AI’s capacity to enhance diagnostic accuracy, accelerate pharmaceutical development, and improve patient care by automating routine tasks, though concerns about data bias and privacy remain critical. The panel further addresses ethical and legal considerations, including intellectual property rights and responsible AI deployment, noting evolving regulatory frameworks and the necessity of human oversight to mitigate misinformation risks. Discussions on global equity recognize AI’s potential to democratize access to advanced tools, particularly in agriculture within developing countries, contingent on reductions in hardware and software costs. The seminar concludes with an optimistic outlook on AI-driven economic expansion, increased creativity, and the redefinition of work-life balance, while emphasizing the importance of lifelong learning, societal responsibility, and inclusive policy-making to ensure equitable benefits from AI integration in business and society.https://cassyni-user-files-prod.s3.amazonaws.com/UwhzZknsPhMhJPCFpGH1pi https://cassyni.com/slides/outline/U7Pe3gBU9sLhg9Atzsp2pV https://cassyni.com/events/U7Pe3gBU9sLhg9Atzsp2pV/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Rrey2Uzqeau8XRs2YknTCa https://cassyni.com/events/U7Pe3gBU9sLhg9Atzsp2pV?videoPreview=1 Panel: Assistive Mobile and Wearable Solutions for Seniorsnohttps://cassyni.com/events/U7Pe3gBU9sLhg9Atzsp2pV?videoPreview=12015-06-24T08:00:00+00:003824.4 School of Public PolicyThis seminar explores recent advances and challenges in assistive mobile and wearable technologies designed to enhance independence, health, and social engagement among seniors. Three innovative devices exemplify breakthroughs in mobility, hearing, and vision support: the Wheel, a compact, agile personal mobility device with advanced maneuverability and remote control features; Bridgy, a smart earpiece integrating hearing enhancement with vital sign monitoring and cognitive support; and Orcam, a wearable AI-powered camera system providing real-time visual assistance and object recognition for the visually impaired. These technologies address critical domains of aging-related decline, including mobility, sensory impairments, and cognitive challenges. Complementing these innovations, Panasonic’s On for Today platform offers an integrated, customizable ecosystem centered on seniors’ needs, facilitating coordinated care through an always-on display and cloud connectivity that supports reminders, messaging, and social interaction, thereby reducing anxiety and promoting autonomy. Empirical research from Georgia Tech’s HomeLab assessed mainstream activity and sleep trackers with 92 older adults, revealing significant barriers in device setup, packaging accessibility, and meaningful data presentation, particularly among those aged 70 and above. Findings emphasize the necessity for simplified interfaces, clearer instructions, and activity metrics aligned with seniors’ health guidelines. AARP’s Innovation at 50 Plus initiative highlights the substantial economic and social potential of technologies targeting the 50+ demographic, identifying key market opportunities in medication management, vitality enhancement, and vital signs monitoring. The seminar underscores the urgent need for integrated, user-centered solutions that bridge consumer devices with healthcare systems, with autonomous vehicles posited as a transformative future assistive technology for sustaining mobility and social connectivity in aging populations.https://cassyni-user-files-prod.s3.amazonaws.com/Rrey2Uzqeau8XRs2YknTCa https://cassyni.com/slides/outline/6sWf4HMuHBXPYPBj8Kbtff https://cassyni.com/events/6sWf4HMuHBXPYPBj8Kbtff/abstract https://cassyni-user-files-prod.s3.amazonaws.com/WQAt4K587dsbxNMLuRiyok https://cassyni.com/events/6sWf4HMuHBXPYPBj8Kbtff?videoPreview=1 STRINGS UN STI Forum 2021nohttps://cassyni.com/events/6sWf4HMuHBXPYPBj8Kbtff?videoPreview=12021-05-04T08:00:00+00:006868.48 School of Public PolicyThe STRINGS project addresses the critical challenge of aligning global science, technology, and innovation (STI) with the United Nations Sustainable Development Goals (SDGs), emphasizing inclusive pathways that respond to pressing planetary and social inequalities. The project integrates macro-level bibliometric mapping, meso-level expert consultations, and micro-level case studies across diverse contexts—including Argentina, Kenya, and India—to analyze how STI priorities correspond with SDG challenges and how diverse actors shape innovation pathways. Findings reveal stark disparities: 94% of SDG-related research originates in high-income countries, with low-income nations contributing a mere 0.2%, and significant misalignments exist between national SDG priorities and research specializations. The project highlights three roles for STI in advancing SDGs: instrumental (addressing concrete challenges such as renewable energy and vaccines), enabling (understanding complex socio-ecological interdependencies), and constitutive (navigating the SDGs as a multidimensional predicament requiring inclusive dialogue across disciplines and knowledge systems). Panel discussions underscore the necessity of building local participatory capabilities, addressing power imbalances, and fostering institutional innovations that integrate science policy, funding, and advice. The importance of catalytic use of SDG frameworks to reorient research agendas is emphasized, alongside the need for new metrics to assess STI impact beyond traditional outputs. Reflections from global governance experts advocate for establishing a global STI observatory, coordinated funding consortia, and regular high-level convenings to enhance transparency, priority-setting, and accountability. The project thus contributes a nuanced, multi-scalar analysis and proposes institutional and policy innovations essential for steering STI toward equitable and sustainable development outcomes.https://cassyni-user-files-prod.s3.amazonaws.com/WQAt4K587dsbxNMLuRiyok https://cassyni.com/events/w2cbStetbzN9HUP7qttwX/abstract https://cassyni-user-files-prod.s3.amazonaws.com/X71Dvj3xZwHwPinXtptbmQ https://cassyni.com/slides/outline/EHEikY4ms3qE2xiC6CTd5f https://cassyni.com/events/EHEikY4ms3qE2xiC6CTd5f/abstract https://cassyni-user-files-prod.s3.amazonaws.com/PNzeet5YwChd9TxtTLpJF8 https://cassyni.com/events/EHEikY4ms3qE2xiC6CTd5f?videoPreview=1 Fundamental Physics Opportunities with Multi-PetaWatt- and Multi-MegaJoule-class Facilitiesnohttps://cassyni.com/events/EHEikY4ms3qE2xiC6CTd5f?videoPreview=12024-03-07T06:00:00+00:004021.12Journal of Plasma PhysicsIn my talk, I will present some recent highlights from my research group in the Clarendon Laboratory, obtained working in partnership with many outstanding international collaborators. These fall under the three broad themes. The first is novel laser-plasma interactions, which include those resulting from twisted light, ionisation injection for laser- and beam-driven wakefield accelerators, along with frequency domain holographic and compressive sensing diagnostic developments relevant to future colliders. The second theme is that of extreme field physics using multi-petawatt laser facilities. These include first principles ionisation processes, absorption processes and ultra-bright attosecond X-rays from high harmonic generation, photon-photon scattering in the non-linear QED regime and, most recently, gravitational wave generation using petaWatt- and/or megaJoule-class facilities. We are now extending these studies to those of gravity-wave detection, with promising preliminary results. The third theme is that of inertial fusion studies. All of these studies indicate that an international, dual-use, 20-MJ ICF/IFE facility, with the first 2-MJ at high repetition rate supplying single-shot high energy amplifiers, will open many new exciting avenues for both fundamental physics and high energy density science in the decades ahead.https://cassyni-user-files-prod.s3.amazonaws.com/PNzeet5YwChd9TxtTLpJF8 https://cassyni.com/slides/outline/GkUjyxJQ4LbiPuBkdtNFob https://cassyni.com/events/GkUjyxJQ4LbiPuBkdtNFob/abstract https://cassyni-user-files-prod.s3.amazonaws.com/xTFpakoWn6NbxzQsGUDnN https://cassyni.com/events/GkUjyxJQ4LbiPuBkdtNFob?videoPreview=1 New Strategies for Dramatically Increasing Confinement in Magnetic Fusion Energynohttps://cassyni.com/events/GkUjyxJQ4LbiPuBkdtNFob?videoPreview=12023-12-07T06:00:00+00:002813.28Journal of Plasma PhysicsThe projected size and cost of a fusion power plant is strongly dependent on plasma confinement. In most magnetic fusion devices, the confinement time is determined by small scale turbulent transport of heat and particles. This turbulence can be suppressed under certain conditions, resulting in enhanced confinement regimes with enormous gradients of temperature and density. I will present a fundamental picture of the physical mechanisms by which such extreme conditions are thermodynamically viable. This fundamental understanding points to strategies by which transport barriers can be controlled and optimized. I will also describe numerical investigations interpreting wide-ranging experimental observations of transport barriers in tokamaks. One of the most pressing challenges for a fusion power plant is the conflicting demands of heat exhaust and confinement. I will introduce a new solution to this conundrum: a divertor concept that works in synergy with transport barriers to unlock even greater gains in confinement. If this can be achieved, it would enable much smaller and cheaper fusion devices than typically envisioned.https://cassyni-user-files-prod.s3.amazonaws.com/xTFpakoWn6NbxzQsGUDnN https://cassyni.com/slides/outline/KDkPL13uezJFeAH7qh4mMF https://cassyni.com/events/KDkPL13uezJFeAH7qh4mMF/abstract https://cassyni-user-files-prod.s3.amazonaws.com/5V5Uyoc8SJ9k7CDen3n5aE https://cassyni.com/events/KDkPL13uezJFeAH7qh4mMF?videoPreview=1 REACH Casual Friday: Team Dynamics & High-Performing Teamsnohttps://cassyni.com/events/KDkPL13uezJFeAH7qh4mMF?videoPreview=12026-02-20T18:00:00+00:003035.88Research Evaluation and Analytics Capacity Hub## This month's Casual Friday Topic: Team Dynamics & High-Performing Teams Most teams possess the talent to succeed, yet many remain stalled by invisible friction and unspoken silos. This casual Friday talk will provide components of a blueprint for fostering strong team dynamics to help turn individual experts into a cohesive, high-performing unit through transparency and shared accountability. In our REACH Casual Friday events we aim to gather virtually with network participants, especially those participating in RAMP. The first 30-minutes will be a focused presenter and topic followed by more causal networking and possible break-out rooms.https://cassyni-user-files-prod.s3.amazonaws.com/5V5Uyoc8SJ9k7CDen3n5aE https://cassyni.com/slides/outline/VbN5JMdvsbvgAfaFro1f2m https://cassyni.com/events/VbN5JMdvsbvgAfaFro1f2m/abstract https://cassyni-user-files-prod.s3.amazonaws.com/VKbufkuBoGakY8SD9DJi5C https://cassyni.com/events/VbN5JMdvsbvgAfaFro1f2m?videoPreview=1 Reactivity Patterns in Baylis-Hillman Ketones: Diversity and Intriguenohttps://cassyni.com/events/VbN5JMdvsbvgAfaFro1f2m?videoPreview=12025-08-28T08:00:00+00:003934.36Thieme India ChemTalksThe Morita–Baylis–Hillman (MBH) ketone is a multifunctional molecule with seemingly endless possibilities for modification. Our recent studies on these reactive olefins, which are obtained by a simple oxidation of MBH adducts, have led to some exciting observations and distinct reactivity patterns, while also affording access to a diverse array of heterocyclic scaffolds (Scheme 1). Recently, we have also isolated a cyclic dienamine motif that can be utilized in further synthetic maneuvers for the construction of frameworks such as acridines, dibenzodiazepines, benzofurans, etc. Our experiences and insights on working with the interesting MBH ketone shall be discussed in the presentation.https://cassyni-user-files-prod.s3.amazonaws.com/VKbufkuBoGakY8SD9DJi5C https://cassyni.com/slides/outline/4QJFwVeAVFgdLDzQq3F2oX https://cassyni.com/events/4QJFwVeAVFgdLDzQq3F2oX/abstract https://cassyni-user-files-prod.s3.amazonaws.com/WPSSP2quoHxSWpTsCxn1fk https://cassyni.com/events/4QJFwVeAVFgdLDzQq3F2oX?videoPreview=1 Deep Learning for Groundwater Modellingnohttps://cassyni.com/events/4QJFwVeAVFgdLDzQq3F2oX?videoPreview=12024-01-25T06:00:00+00:00929.76Leeds Institute for Fluid DynamicsThis talk by Maria Luisa Taccari, a final-year PhD candidate from the University of Leeds, delves into the development of deep learning surrogate models in groundwater flow simulation. Surrogate models serve as efficient approximations of complex numerical groundwater models, like MODFLOW, which are traditionally crucial for water resource management but come with high computational demands. Through her research, Maria Luisa has illustrated that deep learning surrogate models, encompassing standard computer vision models, transformers, and neural operators, can substantially reduce computational demands. These data-driven methods have shown the potential to mimic the capabilities of numerical techniques accurately and efficiently. Finally, the talk also touches upon the application of these models with real-world data, which present unique challenges such as accounting for time-dependent problems, sparse data, and true-world variability.https://cassyni-user-files-prod.s3.amazonaws.com/WPSSP2quoHxSWpTsCxn1fk https://cassyni.com/slides/outline/EmuwurEBhsK3rjHYr9BvV3 https://cassyni.com/events/EmuwurEBhsK3rjHYr9BvV3/abstract https://cassyni-user-files-prod.s3.amazonaws.com/TZA7WwunFwdtdTCZ3s7Dcr https://cassyni.com/events/EmuwurEBhsK3rjHYr9BvV3?videoPreview=1 How to trap heat with thermal metamaterialsnohttps://cassyni.com/events/EmuwurEBhsK3rjHYr9BvV3?videoPreview=12025-10-24T10:30:00+00:002274.36UK Metamaterials NetworkIn order to control the flow of heat, one has to consider the dynamics effects of heating in the temporal domain. Conventional approaches reliant on steady-state diffusion governed by Fourier’s law inherently cannot capture this behaviour. By introducing structure into conductive materials and modelling heat transport using a non-conventional equation (Cattaneo equation), we expose clear signatures of non-Fourier dynamics, thermal waves, interference, delayed propagation, and ultimately trapping heat (temporarily). Our microstructure designs create bottlenecks and constructive interference, producing temperature spikes and elevated central temperatures not possible under standard diffusion and allow for heat trapping for multiple nanoseconds. This work provides a practical route to observe and exploit wave-like thermal behaviour in solids, laying the groundwork for next-gen thermal control in nanoscale systems. https://cassyni-user-files-prod.s3.amazonaws.com/TZA7WwunFwdtdTCZ3s7Dcr https://cassyni.com/events/5tGhCB6dCzGbpSovj7qKnd/abstract https://cassyni-user-files-prod.s3.amazonaws.com/HCDhmotex7X1qMRV4RGa6a https://cassyni.com/slides/outline/DHzktRoVnraSK2LPgzh4Cd https://cassyni.com/events/DHzktRoVnraSK2LPgzh4Cd/abstract https://cassyni-user-files-prod.s3.amazonaws.com/63XXbqwd6oqxUivmkqWzjp https://cassyni.com/events/DHzktRoVnraSK2LPgzh4Cd?videoPreview=1 Innovating Med Ed with AI: Insights from the Macy Reportnohttps://cassyni.com/events/DHzktRoVnraSK2LPgzh4Cd?videoPreview=12025-09-16T06:00:00+00:003504.28AAMCThis webinar explored a Josiah Macy Jr. Foundation–commissioned report on the AI landscape in medical education and its future implications. The speakers highlighted findings from a literature review and interviews with AI innovators, including exemplary uses of AI, its potential for competency-based education, and key challenges such as security, privacy, bias, and resource inequities. The presentation offered insights from [the September 2025 Academic Medicine supplement](https://journals.lww.com/academicmedicine/toc/2025/09001) and the 2024 Macy Foundation Conference on AI in Medical Education. This webinar is part of the Artificial Intelligence in Academic Medicine Webinar Series, hosted by the AAMC. It explores critical concepts, the current landscape, and practical strategies drawn from various perspectives and institutions to support you in navigating the evolving world of AI in academic medicine. For more information, see [the complete series webpage](https://www.aamc.org/about-us/mission-areas/medical-education/artificial-intelligence-ai-academic-medicine-webinar-series). https://cassyni-user-files-prod.s3.amazonaws.com/63XXbqwd6oqxUivmkqWzjp https://cassyni.com/slides/outline/FmEn7r37z9LvfxoxEgbgvZ https://cassyni.com/events/FmEn7r37z9LvfxoxEgbgvZ/abstract https://cassyni-user-files-prod.s3.amazonaws.com/PtRhGWshJEgsURveNAVH3U https://cassyni.com/events/FmEn7r37z9LvfxoxEgbgvZ?videoPreview=1 Risk sharing in a regional IAMnohttps://cassyni.com/events/FmEn7r37z9LvfxoxEgbgvZ?videoPreview=12025-07-06T01:00:00+00:001252.08Risk Sciences[***Risk Sciences***](https://www.keaipublishing.com/en/journals/risk-sciences/) aims to foster diverse, multidisciplinary insights in risk sciences, bridging theory and practice through a series of academic activities. Dr. Wong's research interests mainly lie in Actuarial science, Commodity markets and Financial mathematics. This speech record is an excerpt from Dr. Wong's keynote speech for the Risk Sciences Colloquium – 2025 International Workshop on Risk Sharing (IWRS) , which was held on July 6-7, 2025, in Beijing, China. This video is categorized under ***Climate Change and Sustainability***.https://cassyni-user-files-prod.s3.amazonaws.com/PtRhGWshJEgsURveNAVH3U https://cassyni.com/slides/outline/YZJwoiYrK56mAmVxQFsRqo https://cassyni.com/events/YZJwoiYrK56mAmVxQFsRqo/abstract https://cassyni-user-files-prod.s3.amazonaws.com/CxyJbtve6Vzah2EHodYT8A https://cassyni.com/events/YZJwoiYrK56mAmVxQFsRqo?videoPreview=1 Cosmic Ray Transport in the Multiphase ISMnohttps://cassyni.com/events/YZJwoiYrK56mAmVxQFsRqo?videoPreview=12026-01-29T16:00:00+00:002905.88Journal of Plasma PhysicsThe interstellar medium (ISM) is a complex and multiphase environment governed by a myriad of interconnected processes. Amongst these, an emergent and exciting avenue of study is the impact of cosmic rays (CRs) on driving galactic outflows and regulating star formation. I will present our work investigating the transport of GeV cosmic rays across a diverse range of galactic environments, utilizing TIGRESS MHD and CRMHD simulations of the star-forming ISM. Amongst our findings are that dynamical transport mechanisms (streaming at the ion Alfvén speed and advection with gas motion) are almost solely responsible for GeV CR transport in the extraplanar regions of galaxies, while diffusion along the magnetic field dominates within the primarily neutral ISM of galactic disks. I will discuss the predictive possibilities and consequences of our findings, as well as the exciting future avenues opened by our new CRMHD simulation suite. In addition to CRs, I will also discuss some of my broader work on the impact of plasma physics on star formation, including the impact of non-ideal MHD effects on prestellar core formation.https://cassyni-user-files-prod.s3.amazonaws.com/CxyJbtve6Vzah2EHodYT8A https://cassyni.com/events/BogrGCAQEnshPYozVALQ8d/seminar/qa https://cassyni.com/slides/outline/BogrGCAQEnshPYozVALQ8d https://cassyni.com/events/BogrGCAQEnshPYozVALQ8d/abstract https://cassyni-user-files-prod.s3.amazonaws.com/NZzCCWSas9Eit8wFkYjpmk https://cassyni.com/events/BogrGCAQEnshPYozVALQ8d?videoPreview=1 Measuring the motivational impact of tasks: Self-determination theory and task-based language teachingnohttps://cassyni.com/events/BogrGCAQEnshPYozVALQ8d?videoPreview=12026-03-06T00:00:00+00:003004.92Linguistics and Applied Language StudiesTask-based language teaching (TBLT) is now widely supported as an effective approach to language pedagogy, drawing on theories from psycholinguistics and sociolinguistics (Dörnyei, 2019; Ellis et al., 2020). However, it is only more recently that sustained discussion of motivation within a TBLT framework has begun to emerge (Namkung & Kim, 2024). The foundational element of TBLT is the task, and therefore an important but underexplored question concerns how task design may differentially influence learner engagement and motivation. In this talk, I will introduce Self-Determination Theory (SDT; Ryan & Deci, 2017) as a framework for understanding the motivational impact of tasks and then discuss and illustrate with examples the alignment between the four defining features of a task and the three basic psychological needs of autonomy, competence, and relatedness as described by SDT. I will then report on a small-scale study that reports on the development of an instrument to measure the motivational impact of tasks. A principal components analysis of Rasch residuals was conducted to refine the instrument and examine its underlying structure. I’ll conclude with Implications for task design, classroom-based research, and future empirical work into TBLT and motivation.https://cassyni-user-files-prod.s3.amazonaws.com/NZzCCWSas9Eit8wFkYjpmk https://cassyni.com/events/Q9vaXurQcbeHRhkCk5qZuP/seminar/qa https://cassyni.com/slides/outline/Q9vaXurQcbeHRhkCk5qZuP https://cassyni.com/events/Q9vaXurQcbeHRhkCk5qZuP/abstract https://cassyni-user-files-prod.s3.amazonaws.com/CNLEEBnJrErYEfHfcrUMPk https://cassyni.com/events/Q9vaXurQcbeHRhkCk5qZuP?videoPreview=1 From Turbulence Databases to Data-driven Models: Knowledge Discovery of Scaling Laws and Turbulence Modelingnohttps://cassyni.com/events/Q9vaXurQcbeHRhkCk5qZuP?videoPreview=12026-07-07T13:00:00+00:003642.16AIAA JournalArtificial intelligence is reshaping research paradigms in fluid mechanics. However, the prediction of engineering high-Reynolds-number wall-bounded turbulence remains a major bottleneck in aerodynamic design, particularly for flows involving complex geometries, surface curvature, adverse pressure gradients, and massive separation. This challenge is largely associated with the scarcity of high-fidelity data, incomplete understanding of the underlying physical mechanisms, and the limited predictive capability and generalizability of existing turbulence models. To address these challenges, we constructed AeroFlowData, an aerospace-oriented, high-resolution, high-Reynolds-number turbulence database comprising more than 500 cases and approximately 100 TB of data. The database covers a broad range of canonical and engineering configurations, including hypersonic vehicles, civil aircraft, turbomachinery flows, and supercritical-fluid cases. Then we discovered new mean-velocity and mixing-length scaling laws for wall-bounded turbulence, providing interpretable physical insights into high-Reynolds-number turbulent flows. Furthermore, we developed a data-driven turbulence modeling framework spanning black-box deep-learning models and white-box physics-informed model discovery. By incorporating physical constraints and a partitioned ensemble modeling strategy, the proposed models achieve improved universality and generalization across different flow regimes. The resulting models exhibit enhanced interpretability, robustness, and predictive accuracy, leading to substantially improved predictions for complex separated flows, including high-Reynolds-number airfoils, helicopter rotors, and civil aircraft configurations.https://cassyni-user-files-prod.s3.amazonaws.com/CNLEEBnJrErYEfHfcrUMPk https://cassyni.com/events/KDSY55PAE27G2c2rjc8aBF/seminar/qa https://cassyni.com/slides/outline/KDSY55PAE27G2c2rjc8aBF https://cassyni.com/events/KDSY55PAE27G2c2rjc8aBF/abstract https://cassyni-user-files-prod.s3.amazonaws.com/UoxDFsTmozy63pUsarfszE https://cassyni.com/events/KDSY55PAE27G2c2rjc8aBF?videoPreview=1 Introduction to the 27th international Biometals webinars (iBWs), Exploiting Zinc-Dependent Virulence: A Trojan Horse Strategy Against Pseudomonas aeruginosa, Identifying and targeting the Mg-Fe-PmrAB regulatory circuit reverses phosphate starvation-driven polymyxin resistance in Enterobacteriaceaenohttps://cassyni.com/events/KDSY55PAE27G2c2rjc8aBF?videoPreview=12026-06-02T13:00:00+00:005221.48BioMetalsThis seminar explored distinct mechanisms underlying bacterial virulence and adaptive antimicrobial resistance, focusing on the critical role of metal homeostasis. The first presentation investigated *Pseudomonas aeruginosa*, a significant pathogen in cystic fibrosis (CF) patients. Studies demonstrated that the bacterium's ability to establish infections is highly dependent on its capacity to proliferate in zinc-restricted environments, a condition frequently observed *in situ* in CF patient lungs. Zinc deficiency attenuates virulence factors such as growth, motility, biofilm formation, and oxidative stress resistance, and drives extensive metabolic remodeling towards anaerobic respiration, involving the regulation of over 600 genes. Capitalizing on this zinc dependency, a "Trojan horse" antibiotic, aztreopine, was developed by conjugating aztreonam with a simplified pseudopaline-inspired metallophore. Aztreopine demonstrated significantly enhanced activity (at least one log molar basis) against *P. aeruginosa* in zinc-deficient conditions, with its efficacy reliant on the ZrmA receptor, effective against clinical isolates, and active *in vivo* in *Galleria mellonella*. The second presentation addressed adaptive polymyxin resistance in Enterobacteriaceae during phosphate starvation, a common host stress. Comparative proteomic and genetic analyses in *Escherichia coli* revealed that phosphate starvation upregulates the *arn* genes, leading to L-Ara4N (4-amino-4-deoxy-L-arabinose) modification of lipid A. This modification, observed across various Enterobacteriaceae, reduces the negative charge and adds a positive charge to the outer membrane, thereby conferring polymyxin resistance. The *arn* operon's activation and subsequent polymyxin resistance are governed by the Mg-Fe-PmrAB two-component regulatory circuit, rather than the primary PhoBR phosphate starvation response. Phosphate starvation leads to a decrease in cellular magnesium and an increase in iron mobilization to the cell surface, activating PmrAB. Reversal strategies involving supplementation with excess magnesium or treatment with iron chelators effectively abolished this phosphate starvation-driven polymyxin resistance in Enterobacteriaceae, presenting a targetable vulnerability to combat adaptive resistance.https://cassyni-user-files-prod.s3.amazonaws.com/UoxDFsTmozy63pUsarfszE https://cassyni.com/events/Vb4E3RyBSdjgZ7Kzki5Trm/seminar/qa https://cassyni.com/slides/outline/Vb4E3RyBSdjgZ7Kzki5Trm https://cassyni.com/events/Vb4E3RyBSdjgZ7Kzki5Trm/abstract https://cassyni-user-files-prod.s3.amazonaws.com/AC86E3KCdyRkL8QX2dqRbk https://cassyni.com/events/Vb4E3RyBSdjgZ7Kzki5Trm?videoPreview=1 Recent Developments in Numerical Peridynamic Methods for Solid Mechanicsnohttps://cassyni.com/events/Vb4E3RyBSdjgZ7Kzki5Trm?videoPreview=12026-02-20T13:00:00+00:003034.16Department of AeronauticsInitially, the seminar will cover a few contributions by the author and his co-workers that might be applicable to the most recent works described in the second half of the talk. A coupling approach between numerical discretisations of CCM and PD [1] naturally lends itself to a more efficient numerical solution procedure or to an easier imposition of boundary conditions. A second method of imposing BC locally on a PD model will be presented [2]. The talk will then address the numerical solution of multiphysics problems and some common aspects of such problems [3]. We will consider fully saturated porous media, where fluid pressure or flow can deform the solid or generate cracks in it. The main topic of the presentation will be a PD model for large strain in nearly incompressible materials. Our work makes use of a correspondence model [4, 5], which is based on classical hyperelastic constitutive laws. The final topic will describe an efficient numerical procedure for solving PD problems, based on the work of Bobaru et al. [6]. 1) Overall equilibrium in the coupling of peridynamics and classical continuum mechanics, Ongaro, G., Seleson, P., Galvanetto, U., Ni, T., Zaccariotto, M.; Comp. Meth. Appl. Mech. Eng., 2021, 381, 113515. 2) A New Surface Node Method to Accurately Model the Mechanical Behavior of the Boundary in 3D State-Based Peridynamics, Scabbia, F., Zaccariotto, M., Galvanetto, U.; J. Peridyn. Nonl. Model., 2023, 5(4), pp. 521–555. 3) A Peridynamic-enhanced finite element method for Thermo–Hydro–Mechanical coupled problems in saturated porous media involving cracks, Ni, T., Fan, X., Zhang, J., ... Galvanetto, U., Schrefler, B.A.; Comp. Meth. Appl. Mech. Eng., 2023, 417, 116376. 4) A non-ordinary state-based peridynamic method to model solid material deformation and fracture, Warren, T.L., Silling, S.A., Askari, A., ... Epton, M.A., Xu, J.; Int. J. Sol. Struct., 2009, 46(5), pp. 1186–1195. 5) Peridynamic correspondence model for nearly-incompressible finite elasticity, Scabbia, F., Diana, V., Fantoni, F., Zaccariotto, M., Galvanetto, U.; Comp. Meth. Appl. Mech. Eng., 2025, 447, 118350. 6) PeriFast/Dynamics: A MATLAB Code for Explicit Fast Convolution-based Peridynamic Analysis of Deformation and Fracture, Jafarzadeh, S., Mousavi, F., Wang, L., Bobaru, F.; J. Peridyn. Nonl. Model., 2024, 6(1), pp. 33–61https://cassyni-user-files-prod.s3.amazonaws.com/AC86E3KCdyRkL8QX2dqRbk https://cassyni.com/slides/outline/S8WzieSWNRs3XR2S73hWKw https://cassyni.com/events/S8WzieSWNRs3XR2S73hWKw/abstract https://cassyni-user-files-prod.s3.amazonaws.com/PCfnE5grL1Td3FB43BqnAa https://cassyni.com/events/S8WzieSWNRs3XR2S73hWKw?videoPreview=1 SSP Innovation Showcase (Summer 2023)nohttps://cassyni.com/events/S8WzieSWNRs3XR2S73hWKw?videoPreview=12023-07-14T04:00:00+00:004030.68SSP Society for Scholarly PublishingA special complimentary webinar highlighting new and exciting industry innovations. Speakers representing innovative companies will present brief presentations on solutions and technology. This is a unique opportunity to get a glimpse of the latest developments in the industry. Featuring Cactus, Hum, Kriyadocs, Morressier, Origin Reports, and Xpublisher.https://cassyni-user-files-prod.s3.amazonaws.com/PCfnE5grL1Td3FB43BqnAa https://cassyni.com/events/5PHcmwGTwCbnPRa9pvnASR/abstract https://cassyni-user-files-prod.s3.amazonaws.com/3n3GM7Wnd4yNhf5xTAmg8W https://cassyni.com/events/7rXe1MW68VNGkN3iNcgoAM/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Md389dh52D3qzdwDyjfbKt https://cassyni.com/slides/outline/Ubm1x4g8ZidXtMVzejc93s https://cassyni.com/events/Ubm1x4g8ZidXtMVzejc93s/abstract https://cassyni-user-files-prod.s3.amazonaws.com/CGaCHSJVnTNr5mYyhma3c2 https://cassyni.com/events/Ubm1x4g8ZidXtMVzejc93s?videoPreview=1 Pathways to Decarbonization – The Role of Science and Technologynohttps://cassyni.com/events/Ubm1x4g8ZidXtMVzejc93s?videoPreview=12016-05-31T06:00:00+00:002330.48 School of Public PolicyThe urgent global imperative for deep decarbonization drives significant advancements in energy science and technology, spanning chemical hydrogen storage, utility-scale renewable integration, and electricity grid modernization. Research into chemical hydrogen storage has expanded beyond traditional metal hydrides to include novel solid-state materials like metal nitride–hydrogen systems. While these systems broaden chemical options, a critical challenge remains in developing materials that simultaneously offer high capacity, near-ambient hydrogen release, stability, reversibility, and recyclability, capable of replacing high-pressure cylinders with storage at tens of bars. In grid-scale applications, the decreasing cost of wind and solar power has spurred their rapid, gigawatt-scale deployment, necessitating systemic innovation for stable integration. Solutions involve new flexibility sources and demand-side management, such as optimizing electric heating based on hourly prices and aggregating water heater loads for frequency regulation. District heating networks are also utilized to provide flexibility to electricity systems. The electricity industry is undergoing rapid transformation, with power electronics facilitating microgrids and renewable interconnection. The convergence of solar, wind, and storage technologies, coupled with behind-the-meter opportunities, presents substantial potential. Innovative business models, exemplified by projects combining solar and battery storage leveraging frequency markets, demonstrate pathways to economically viable, unsubsidized decarbonization. Achieving these goals requires flexible infrastructure, cross-disciplinary collaboration, and robust regulatory and market frameworks tailored to diverse regional contexts.https://cassyni-user-files-prod.s3.amazonaws.com/CGaCHSJVnTNr5mYyhma3c2 https://cassyni.com/events/HEsjzyJwsYpbV8Yoz2LudX/abstract https://cassyni-user-files-prod.s3.amazonaws.com/7Lb7ufie6Mfn4e5tZpY8K8 https://cassyni.com/events/T7qpveFSehtvLeYqVb7GmT/seminar/qa https://cassyni.com/slides/outline/T7qpveFSehtvLeYqVb7GmT https://cassyni.com/events/T7qpveFSehtvLeYqVb7GmT/abstract https://cassyni-user-files-prod.s3.amazonaws.com/9eo1V65PuAFQqVYcaTtxVL https://cassyni.com/events/T7qpveFSehtvLeYqVb7GmT?videoPreview=1 Artificial Intelligence for Multimorbidity Management in Women: From Heart Disease to Mental Healthnohttps://cassyni.com/events/T7qpveFSehtvLeYqVb7GmT?videoPreview=12026-05-26T09:00:00+00:003736.36Women's Health“Women are not failing our models—our models have been failing women. For too long, cardiovascular risk has been measured against a male default. As data scientists, we now have the tools to change that. I’m excited to share my work on moving beyond gender as a simple variable toward a multimodal AI approach designed specifically for the female heart.” - Dr Sorayya Malek, Guest Editor of the Special Collectionhttps://cassyni-user-files-prod.s3.amazonaws.com/9eo1V65PuAFQqVYcaTtxVL https://cassyni.com/events/4PzQgZyR4HVdifk9ixJqdX/abstract https://cassyni-user-files-prod.s3.amazonaws.com/J5t3MAAgrwQgoMiEdAhagN https://cassyni.com/slides/outline/Emc6evZSGu84FB3Hk4FjK3 https://cassyni.com/events/Emc6evZSGu84FB3Hk4FjK3/abstract https://cassyni-user-files-prod.s3.amazonaws.com/9XYYrLzjCVTWEts8s6o7Ui https://cassyni.com/events/Emc6evZSGu84FB3Hk4FjK3?videoPreview=1 Computational design of metal hydrides for hydrogen storagenohttps://cassyni.com/events/Emc6evZSGu84FB3Hk4FjK3?videoPreview=12026-03-16T23:15:00+00:001986.68The MacDiarmid Institute for Advanced Materials and NanotechnologyIn a sustainable economy built on renewable energy, hydrogen plays a key role for storing energy and replacing fossil fuels. An efficient way to store hydrogen is to keep it in the solid state by binding it chemically in a metal hydride, which is particularly useful for seasonal energy storage or for applications where safety is a concern. Since experimental studies with hydrogen can be challenging and time-consuming, computational tools are extremely valuable for gaining a deeper understanding of the processes underlying the (de-)hydrogenation reaction. In this seminar, I will highlight our recent work on predicting the thermodynamics, interface energies, and volume expansion of metal-hydrogen systems using different computational methods. We leverage available experimental and computational data to build machine learning models as well as more sophisticated thermodynamic models for the calculation of phase diagrams (CALPHAD) to find novel metal hydride compositions and fine-tune existing alloys. Additionally, atomic-scale calculations based on density functional theory (DFT) are employed to model interfaces between the metal and hydride phases to inform meso-scale models and gain insights into nucleation barriers. As hydrogen is the lightest element of the periodic table, we also perform simulations that go beyond the classical approximation and test what happens if we treat the whole hydrogen atom as a quantum object instead.https://cassyni-user-files-prod.s3.amazonaws.com/9XYYrLzjCVTWEts8s6o7Ui https://cassyni.com/slides/outline/NBMnTonCG8MctEG9zW3uMf https://cassyni.com/events/NBMnTonCG8MctEG9zW3uMf/abstract https://cassyni-user-files-prod.s3.amazonaws.com/9ndGLrGHdYgHGwM4ZsknWa https://cassyni.com/events/NBMnTonCG8MctEG9zW3uMf?videoPreview=1 Publishing with Purpose: Beyond the Heart (Lightning Talk)nohttps://cassyni.com/events/NBMnTonCG8MctEG9zW3uMf?videoPreview=12026-02-25T13:00:00+00:00237.64Researcher to ReaderHeart failure research centres on the heart, yet patients often experience shortness of breath, reframing the disease as cardiopulmonary. This illustrates why Publishing with Purpose™ matters. Society publishers play a critical role in ensuring that clinically important cross-disciplinary insights reach the right audiences, by prioritizing scientific connection over commercial segmentation.https://cassyni-user-files-prod.s3.amazonaws.com/9ndGLrGHdYgHGwM4ZsknWa https://cassyni.com/events/2RRccTuChpCyBCG6yNXB5o/seminar/qa https://cassyni.com/slides/outline/2RRccTuChpCyBCG6yNXB5o https://cassyni.com/events/2RRccTuChpCyBCG6yNXB5o/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Er9zk3MiuTHtdiKkyvTitn https://cassyni.com/events/2RRccTuChpCyBCG6yNXB5o?videoPreview=1 Physical aspects of magnetic nozzle radiofrequency plasma thrusternohttps://cassyni.com/events/2RRccTuChpCyBCG6yNXB5o?videoPreview=12026-04-30T15:00:00+00:003150.44Journal of Plasma PhysicsA magnetic nozzle radiofrequency (rf) plasma thruster is one of electric propulsion devices for space propulsion, consisting of a rf plasma source and a magnetic nozzle. A high density plasma produced by an rf discharge is transported along the magnetic field lines and accelerated by the magnetic nozzle. The reaction forces are exerted onto the physical boundary and the magnetic fields, which propels a spacecraft. The system is very simple, while it contains many aspects of physics. Here I would like to present overview of our research on this configuration.https://cassyni-user-files-prod.s3.amazonaws.com/Er9zk3MiuTHtdiKkyvTitn https://cassyni.com/slides/outline/Ki7mEPYa4qb5r52NXiFYMT https://cassyni.com/events/Ki7mEPYa4qb5r52NXiFYMT/abstract https://cassyni-user-files-prod.s3.amazonaws.com/U2prtNKF92p2woX27T2xr2 https://cassyni.com/events/Ki7mEPYa4qb5r52NXiFYMT?videoPreview=1 F5 – From Silos to Synergy: Scaling the Research Ecosystemnohttps://cassyni.com/events/Ki7mEPYa4qb5r52NXiFYMT?videoPreview=12026-04-21T09:15:00+00:001480.12Research Analytics SummitImplementing successful research ecosystem requires more than software, it demands a cultural shift in strategy and a user – driven mission. Many institutions struggle with data silos and fragmented teams as they work to grow their research strategy. If this sounds familiar, you’re not alone. This presentation delves into two case studies, Indiana University and the University Toronto, each at different points in their journey to transform their research strategies. Learn how these universities went from legacy workflows to connected solutions that support cross – campus decision – making and responsible research evaluation. As seen in our multi – campus use cases, moving to a unified data structure allows universities to support improved reporting and benchmarking, and increased visibility into research outputs. Additional tools add efficiencies for your uses: bi – direction data integrations, AI – powered automated workflows, and faculty – centric designs. We will share how an intentional approach to stakeholder engagement allowed research administrators to develop cross – functional teams, discover local champions, and foster a culture of trust in their new research evaluation process. Learn how you can take these best practices back to your institution and build a scalable research ecosystem designed to grow with your institution, turning research management and data analytics into drivers for your institution’s success.https://cassyni-user-files-prod.s3.amazonaws.com/U2prtNKF92p2woX27T2xr2 https://cassyni.com/slides/outline/Y4KsPUih3HRwjkGBW4pGVb https://cassyni.com/events/Y4KsPUih3HRwjkGBW4pGVb/abstract https://cassyni-user-files-prod.s3.amazonaws.com/NjLCaisRGVby4q4wm5F9CJ https://cassyni.com/events/Y4KsPUih3HRwjkGBW4pGVb?videoPreview=1 I6 – Lightning Talks: (1) From Data to Insights: Research Metric Utilization at a National Lab (2) How We Are Learning Research Analytics Without an Analytics Office: A Small-Institution REACH Case (3) Advancing AI Implementation and Governance in Researcnohttps://cassyni.com/events/Y4KsPUih3HRwjkGBW4pGVb?videoPreview=12026-04-21T13:30:00+00:001860.64Research Analytics SummitLightning Talks: (1) From Data to Insights: Research Metric Utilization at a National Lab (2) How We Are Learning Research Analytics Without an Analytics Office: A Small-Institution REACH Case (3) Advancing AI Implementation and Governance in Research Administration at Emerging Research Institutions Presenters: (1) Kimberly Schramm (Universities Research Association) (2) Mysty Underwood (East Tenessee State University) (3) Douglas Dechow (Advancing AI Impelmentation and Governance in Research Adminsitration at Emerging Research Institutions)https://cassyni-user-files-prod.s3.amazonaws.com/NjLCaisRGVby4q4wm5F9CJ https://cassyni.com/slides/outline/4tfdqt8pu6yTY8jfX4Rooj https://cassyni.com/events/4tfdqt8pu6yTY8jfX4Rooj/abstract https://cassyni-user-files-prod.s3.amazonaws.com/VvrTKhS4eQFdTq23FGEtMt https://cassyni.com/events/4tfdqt8pu6yTY8jfX4Rooj?videoPreview=1 Organic 2D Crystals for Electronics and Quantum Materialsnohttps://cassyni.com/events/4tfdqt8pu6yTY8jfX4Rooj?videoPreview=12026-05-20T07:50:00+00:002461.8Connecting Science, Publishing, and Innovation**Plenary Lecture** Beyond graphene and inorganic two-dimensional materials, organic two-dimensional crystals (O2DCs) are emerging as a chemically programmable platform for electronics and quantum materials. Built from π-conjugated molecular building blocks, these synthetic layered systems combine structural precision, chemical tunability, and controllable interlayer interactions, enabling the design of electronic structures and transport properties at the molecular scale. In this lecture, I will first introduce advances in electronically active organic 2D frameworks, including 2D conjugated polymers and conjugated metal–organic frameworks (2D c-MOFs). These materials feature periodic π-conjugated networks and tunable covalent/coordination lattices that enable the design of electronic band structures and strongly coupled electronic systems, opening opportunities to explore charge transport, spin physics, and correlated electronic phenomena. These developments are also driving new device concepts in the emerging field of MOFtronics. Next, I will discuss our recent progress in the bottom-up synthesis of highly crystalline 2D polymer crystals, particularly through on-water surface synthesis strategies. The confined water surface provides a unique reaction environment that enables controlled 2D polymer growth and the formation of single- and few-layer 2D polymer crystals with long-range structural order. These materials exhibit extended in-plane conjugation, tunable electronic properties, and emerging charge and ion transport, establishing them as a new materials platform for organic electronics and energy-related applications. Finally, I will present our recent work on organic 2D van der Waals heterostructures. Using sequential on-water surface assembly, we achieve programmable layer-by-layer stacking of chemically distinct 2D crystals with controlled lattice registry, stacking sequence, and thickness. Such control over interlayer coupling enables emergent interfacial phenomena, including charge transfer, built-in electric fields, and novel electronic transport behavior. These advances establish O2DCs as a versatile materials platform bridging synthetic chemistry, materials science, and condensed-matter physics, opening new directions for next-generation electronics and quantum materials.https://cassyni-user-files-prod.s3.amazonaws.com/VvrTKhS4eQFdTq23FGEtMt https://cassyni.com/slides/outline/SdCDsxbvDFLsLt1wu9pUW9 https://cassyni.com/events/SdCDsxbvDFLsLt1wu9pUW9/abstract https://cassyni-user-files-prod.s3.amazonaws.com/PGzgegN1jRSc8f2j3MSJSi https://cassyni.com/events/SdCDsxbvDFLsLt1wu9pUW9?videoPreview=1 Intelligent Sports and Health • Series IV — The Integration and Application of Intelligent Technologies in Sports Performance and Medical Rehabilitationnohttps://cassyni.com/events/SdCDsxbvDFLsLt1wu9pUW9?videoPreview=12026-03-10T01:00:00+00:003358.56NoneTo promote academic exchanges, [Intelligent Sports and Health(ISH)](https://www.keaipublishing.com/en/journals/intelligent-sports-and-health/) hosts a series of thematic seminars. Renowned experts and active researchers are invited to share their cutting‑edge research outcomes On Mar. 10, 2026, Intelligent Sports and Health held the Youth Scholars Forum: The Integration and Application of Intelligent Technologies in Sports Performance and Medical Rehabilitationhttps://cassyni-user-files-prod.s3.amazonaws.com/PGzgegN1jRSc8f2j3MSJSi https://cassyni.com/events/5sxqwFRsn25cCtZfd2u8cd/abstract https://cassyni.com/events/FkvvrvNNZB9w4QZh8bfVkZ/seminar/qa https://cassyni.com/slides/outline/FkvvrvNNZB9w4QZh8bfVkZ https://cassyni.com/events/FkvvrvNNZB9w4QZh8bfVkZ/abstract https://cassyni-user-files-prod.s3.amazonaws.com/KFys16dcM2u7KZMycfQxY6 https://cassyni.com/events/FkvvrvNNZB9w4QZh8bfVkZ?videoPreview=1 Thieme Cheminar: Bioorthogonal Chemistrynohttps://cassyni.com/events/FkvvrvNNZB9w4QZh8bfVkZ?videoPreview=12026-04-22T12:00:00+00:007258.24Thieme GroupBioorthogonal chemistry offers powerful ways to carry out abiotic reactions within living systems, giving researchers the tools to observe and influence biology with exceptional selectivity. The field continues to evolve rapidly, with new ideas and approaches shaping its role in chemical biology and beyond. In this Thieme WebCheminar, Annemieke Madder, Kim Bonger and Asier Unciti‑Broceta—contributors to the Science of Synthesis volume Abiotic Reactions in Live Environments (edited by José Mascareñas and Maria Tomás-Gamasa)—will share their perspectives on current directions in bioorthogonal chemistry and how the area is developing across different research contexts. Chaired by Maria Tomás‑Gamasa, the session offers insights into how modern chemical methods can be used to study and manipulate biological systems.https://cassyni-user-files-prod.s3.amazonaws.com/KFys16dcM2u7KZMycfQxY6 https://cassyni.com/events/8MEVHJBPNfmsPXVrNPdwFT/seminar/qa https://cassyni.com/slides/outline/8MEVHJBPNfmsPXVrNPdwFT https://cassyni.com/events/8MEVHJBPNfmsPXVrNPdwFT/abstract https://cassyni-user-files-prod.s3.amazonaws.com/LcuKmu2h776VNwLe6UbLTp https://cassyni.com/slides/outline/Ng31d7wc6wqShhFfncAsXs https://cassyni.com/events/Ng31d7wc6wqShhFfncAsXs/abstract https://cassyni-user-files-prod.s3.amazonaws.com/bKwkvewkCrXhuSdK5uWBg https://cassyni.com/events/Ng31d7wc6wqShhFfncAsXs?videoPreview=1 Episode 4: Conversations with Jim Allison (Nobel Laureate) and Pam Sharmanohttps://cassyni.com/events/Ng31d7wc6wqShhFfncAsXs?videoPreview=12025-10-23T08:00:00+00:002469.0Advanced ScienceIn this latest episode, I chat with Dr. Jim Allison (Nobel Laureate, MD Anderson) and Dr. Pam Sharma (Director, Allison Institute) about how precision immunology, neuroscience, and data science are converging to reshape cancer research and treatment. Highlights from our conversation include: • The personal and professional motivations that have shaped Dr. Allison and Dr. Sharma’s groundbreaking research. • Complexity: insights into tumor microenvironment heterogeneously across tumors and patients. • Predictive biomarkers in personalized immunotherapy. • Strategic use of AI and machine learning to accelerate discovery. • Navigating uncertainty for early career researchers. https://cassyni-user-files-prod.s3.amazonaws.com/bKwkvewkCrXhuSdK5uWBg https://cassyni.com/slides/outline/W5m5KNeUgp9HCGn8kV2bws https://cassyni.com/events/W5m5KNeUgp9HCGn8kV2bws/abstract https://cassyni-user-files-prod.s3.amazonaws.com/7XULjttCRBWCpU3tNMAr6J https://cassyni.com/events/W5m5KNeUgp9HCGn8kV2bws?videoPreview=1 Navigating the Data Soup: Web3, AI, and the Future of Healthcare Datanohttps://cassyni.com/events/W5m5KNeUgp9HCGn8kV2bws?videoPreview=12026-04-01T13:00:00+00:003574.04AAMCAI and cloud technologies are advancing rapidly in medicine, but fragmented data systems and privacy constraints continue to limit access to patient‑level data. New platforms leverage blockchain, encryption, and tokenization to support data privacy and provenance, yet most academic medical centers struggle to operationalize these tools. This webinar explored how Web 3.0 technologies could help address persistent challenges in healthcare data governance and use. This webinar is part of the Artificial Intelligence in Academic Medicine Webinar Series, hosted by the AAMC. It explores critical concepts, the current landscape, and practical strategies drawn from various perspectives and institutions to support you in navigating the evolving world of AI in academic medicine. For more information, see [the complete series webpage](https://www.aamc.org/about-us/mission-areas/medical-education/artificial-intelligence-ai-academic-medicine-webinar-series). https://cassyni-user-files-prod.s3.amazonaws.com/7XULjttCRBWCpU3tNMAr6J https://cassyni.com/slides/outline/YZ16Ynt6t6umZDFhJAwEfo https://cassyni.com/events/YZ16Ynt6t6umZDFhJAwEfo/abstract https://cassyni-user-files-prod.s3.amazonaws.com/UH6NEsLoPFGaMg7eiD3E4n https://cassyni.com/events/YZ16Ynt6t6umZDFhJAwEfo?videoPreview=1 Bearing Witness in Real Time: Dynamic Research and the Flash Survey Methodnohttps://cassyni.com/events/YZ16Ynt6t6umZDFhJAwEfo?videoPreview=12026-08-20T20:00:00+00:003763.04Family MedicineLearning objectives: - Describe the principles of a newly forming methodology: dynamic research - Understand how Flash Surveys, as a method, balance fidelity and flexibility to generate real-time, practice-based evidence - Learn to strategically assess the trustworthiness of evidence generated from non-probability samples.https://cassyni-user-files-prod.s3.amazonaws.com/UH6NEsLoPFGaMg7eiD3E4n https://cassyni.com/slides/outline/R9H2rYBEJEcFoB4nk1KcDj https://cassyni.com/events/R9H2rYBEJEcFoB4nk1KcDj/abstract https://cassyni-user-files-prod.s3.amazonaws.com/6Gcsnac9nPuDr6HuyLLijp https://cassyni.com/events/R9H2rYBEJEcFoB4nk1KcDj?videoPreview=1 Kidney Talks - Finerenone: What has changed for primary care?nohttps://cassyni.com/events/R9H2rYBEJEcFoB4nk1KcDj?videoPreview=12026-07-22T09:00:00+00:001166.24Education for Primary Care Health Care ProfessionalsChronic kidney disease (CKD), particularly diabetic kidney disease (DKD), presents significant challenges in progression and associated cardiovascular events. Finerenone, a non-steroidal mineralocorticoid receptor antagonist (MRA), offers a distinct therapeutic approach. This agent demonstrates high potency and selectivity for the mineralocorticoid receptor, with no relevant affinity for glucocorticoid, androgen, estrogen, or progesterone receptors, differentiating it from steroidal MRAs and minimizing hormonal side effects. Clinical studies, including FIDELIO, have established its efficacy in patients with type 2 diabetes and kidney disease already receiving standard-of-care renin-angiotensin system (RAS) inhibitors. Finerenone treatment led to an 18% reduction (Hazard Ratio) in the primary renal composite endpoint (sustained eGFR decrease ≥40%, renal death, dialysis, or transplant) over three years, with a number needed to treat of 29. Evidence also supports benefits in heart failure with preserved ejection fraction, and studies are exploring its use in type 1 diabetes and non-diabetic kidney disease. The additive benefits of finerenone alongside SGLT2 inhibitors and GLP-1 receptor agonists significantly reduce CKD progression and mortality, potentially halving the risk of kidney failure. While hyperkalemia is a recognized side effect, its incidence is lower than with steroidal MRAs and poses minimal risk for patients with an eGFR above 45 mL/min. Current guidelines recommend finerenone for slowing DKD progression. Proposed shifts in prescribing protocols will enable primary care initiation for eligible patients with eGFR > 45 mL/min, aiming for faster access to optimize renal-protective therapy, delay disease progression, and improve long-term patient outcomes by preventing the need for dialysis.https://cassyni-user-files-prod.s3.amazonaws.com/6Gcsnac9nPuDr6HuyLLijp https://cassyni.com/events/3QkSpTi8z6EqzRnWMuvwXK/abstract https://cassyni-user-files-prod.s3.amazonaws.com/7GjBmTtXs6LjzJ1rHjZ8bG https://cassyni.com/events/AKpuU2mV8VzdVEn5jMVsg1/seminar/qa https://cassyni.com/events/AKpuU2mV8VzdVEn5jMVsg1/abstract https://cassyni-user-files-prod.s3.amazonaws.com/XckBUWitpgRhaSoK9r7iiJ https://cassyni.com/events/AKpuU2mV8VzdVEn5jMVsg1?videoPreview=1 Handling Time-Dependent Variability in Sampling Theorynohttps://cassyni.com/events/AKpuU2mV8VzdVEn5jMVsg1?videoPreview=12026-05-05T15:00:00+00:003941.76Journal of Statistical Theory and PracticeEstimation is a fundamental concept in statistics, where sample data are utilized to infer unknown population parameters. The use of auxiliary information, which is correlated with the study variable, has long been recognized as an effective approach to enhance the efficiency and precision of estimators. In recent years, memory-type estimators have gained considerable attention due to their ability to incorporate both current and past observations, thereby capturing underlying data dynamics more effectively. These estimators employ smoothing parameters to regulate the contribution of historical information, resulting in reduced estimation error and improved efficiency. In practical scenarios, data often exhibit temporal trends and fluctuations, which can adversely affect the performance of conventional estimators that assign equal weights to all observations. To address this limitation, the Exponentially Weighted Moving Average (EWMA) approach has been widely adopted. EWMA assigns exponentially decreasing weights to past observations, giving more importance to recent data points through a single smoothing parameter. This mechanism enables a balance between responsiveness to recent changes and stability against random fluctuations. The present study highlights the role of EWMA-based memory-type estimation in improving estimation accuracy. It demonstrates that by incorporating temporal structure and auxiliary information, EWMA-based estimators outperform traditional estimators in terms of variance reduction and efficiency, making them highly suitable for real-world applications involving time-dependent data.https://cassyni-user-files-prod.s3.amazonaws.com/XckBUWitpgRhaSoK9r7iiJ https://cassyni.com/events/PfMqq7kYPDsKXEMv8zByCZ/seminar/qa https://cassyni.com/slides/outline/PfMqq7kYPDsKXEMv8zByCZ https://cassyni.com/events/PfMqq7kYPDsKXEMv8zByCZ/abstract https://cassyni-user-files-prod.s3.amazonaws.com/C8Ci6Nv6hM7VjmVM9LuqRY https://cassyni.com/events/PfMqq7kYPDsKXEMv8zByCZ?videoPreview=1 A Rapid Assessment Approach for Skin Stratum‐Targeted Drug Delivery Systems Using Mass Spectrometry Imaging and Spatial Clusteringnohttps://cassyni.com/events/PfMqq7kYPDsKXEMv8zByCZ?videoPreview=12026-08-21T08:00:00+00:002165.28Small Science JournalI will discuss a novel mass spectrometry imaging-based concept for rapid visualization and evaluation of an active pharmaceutical ingredient (API) distribution across skin layers following dermal delivery. This innovative approach integrates desorption electrospray ionization mass spectrometry imaging (DESI-MSI) with a newly developed automated computational tool (access provided) that efficiently processes mass spectrometry imaging data, isolating skin tissue signals from background interference and segmenting the tissue into precise layers. The tool achieves detailed and facile assessment of API localization within skin strata in less than ten minutes per skin specimen. To validate this approach, we designed and characterized three nanoscale dermal drug delivery systems (DDSs) for the antifungal terbinafine that target distinct skin strata-ethosomes, transethosomes, and microemulsion. API permeation in human and porcine skin was evaluated using both manual and automated workflows. The integrated approach demonstrated superior accuracy in skin distribution analysis, substantial reduction in processing time, and improved efficiency in signal-tissue overlay. Comparative analysis of DDSs revealed marked differences in drug permeation depth and localization, with transethosomes showing the greatest potential for deeper dermal delivery. This approach is not only a powerful tool for DDSs evaluation but also enables detailed kinetic studies, providing valuable insights into drug permeation dynamics. https://cassyni-user-files-prod.s3.amazonaws.com/C8Ci6Nv6hM7VjmVM9LuqRY https://cassyni.com/events/LCpcWLDsK1zgVY4MVKp1fj/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Bh3hN8Ho3yWRnp6ZruJEyL https://cassyni.com/slides/outline/X55uXNTQy6BA1otP6s3hcZ https://cassyni.com/events/X55uXNTQy6BA1otP6s3hcZ/abstract https://cassyni-user-files-prod.s3.amazonaws.com/RK6JSqAYJrD6Bq5WEj6gwY https://cassyni.com/events/X55uXNTQy6BA1otP6s3hcZ?videoPreview=1 Presentation of EAJ Issue 16/1 - June 22ndnohttps://cassyni.com/events/X55uXNTQy6BA1otP6s3hcZ?videoPreview=12026-06-22T15:00:00+00:003570.2European Actuarial JournalActuarial science faces ongoing challenges in designing robust insurance products, managing diverse risks, and ensuring regulatory compliance. One area of focus involves life insurance policies supported by expected lapse rates, where insurers leverage anticipated policy terminations for pricing. Analysis of these policies, particularly in scenarios involving adverse selection where high-risk policyholders are less likely to lapse, indicates a substantial increase in potential insurance losses. Using a surplus equation model, it is shown that if expected lapses are not met, the expected present value of insurance losses can be significantly higher (e.g., nearly nine times more) than anticipated profits, with these costs being more pronounced at early policy issue ages. In the realm of parametric insurance, a critical concern is basis risk, the mismatch between an index-triggered payout and the actual loss experienced. A framework is developed to minimize this risk, utilizing an asymmetric squared approach to quantify expected basis risk. This approach demonstrates that optimal payment schemes correspond to conditional expectiles, offering a method for contract design that aligns payouts with policyholder risk perception. These schemes are shown to increase with the importance placed on avoiding undercompensation, and they can be practically implemented through asymmetric least squares regression. To support analysis and benchmarking of actuarial methods within the Solvency II regulatory framework, an open-source internal risk model, openIRM, is introduced. This MATLAB-based model, available with R and Python wrappers, integrates a G2++ two-factor interest rate model, a generalized Black–Scholes stock model, and an advanced policyholder model, performing nested Monte Carlo simulations. The model generates density distributions of basic own funds that reflect varying market conditions and provides insights into how different available capital estimation methods influence dispersion, serving as a publicly accessible tool for risk assessment and capital requirement evaluation.https://cassyni-user-files-prod.s3.amazonaws.com/RK6JSqAYJrD6Bq5WEj6gwY https://cassyni.com/events/8quiScLoDVFhDJ5D8LNEeq/seminar/qa https://cassyni.com/slides/outline/8quiScLoDVFhDJ5D8LNEeq https://cassyni.com/events/8quiScLoDVFhDJ5D8LNEeq/abstract https://cassyni-user-files-prod.s3.amazonaws.com/8UCEr3tVf1QZqGy9BdyaWi https://cassyni.com/events/8quiScLoDVFhDJ5D8LNEeq?videoPreview=1 Systems Design and Optimization in Electrified Aviation: Models, Methods, and Emerging Insightsnohttps://cassyni.com/events/8quiScLoDVFhDJ5D8LNEeq?videoPreview=12026-06-17T12:00:00+00:003449.36Brahmal Vasudevan Institute for Sustainable AviationThe electrification of aircraft requires more than incremental changes to propulsion: it calls for a fundamentally new way of thinking about how aircraft, propulsion architectures, power management systems, and operations interact as a unified whole. At the Integrated Design of Efficient Aerospace Systems (IDEAS) Laboratory at the University of Michigan, we develop computational frameworks that couple physics-based modeling, multidisciplinary design optimization, and systems engineering, all accelerated by machine learning, to address the challenges and opportunities of this evolving field. This seminar will show how we leverage these frameworks to rapidly explore the complex trade-offs inherent in novel aircraft concepts. We will discuss recent technical results and insights from our research, emphasizing viable design strategies and architectures that demonstrate significant efficiency gains in electrified aircraft. Key topics will include trade-off analysis across vehicle configuration, propulsion–power integration, and operational profiles, illustrated with examples drawn from our open-source design tools and current projects. https://cassyni-user-files-prod.s3.amazonaws.com/8UCEr3tVf1QZqGy9BdyaWi https://cassyni.com/slides/outline/SBekMdvdcxBTFtJaAkcCm https://cassyni.com/events/SBekMdvdcxBTFtJaAkcCm/abstract https://cassyni-user-files-prod.s3.amazonaws.com/LupohApvXKfq5zYQoNE7VQ https://cassyni.com/events/SBekMdvdcxBTFtJaAkcCm?videoPreview=1 AEHS Forum Series 21st • Exercise, Skeletal Muscle Mitochondrial Plasticity, and Metabolic Healthnohttps://cassyni.com/events/SBekMdvdcxBTFtJaAkcCm?videoPreview=12026-06-04T11:30:00+00:002548.36NoneTo further boost academic exchanges and build a more dynamic and diversified academic communication platform, [Advanced Exercise and Health Science(AEHS)](https://www.keaipublishing.com/en/journals/advanced-exercise-and-health-science/) has decided to regularly launch the AEHS Online Forum starting from January 2024. AEHS welcomes experts and scholars to share the latest research findings and exchange academic insights on this platform.https://cassyni-user-files-prod.s3.amazonaws.com/LupohApvXKfq5zYQoNE7VQ https://cassyni.com/events/3uRfymsYpuifpCMs7rfEvh/abstract https://cassyni-user-files-prod.s3.amazonaws.com/KeftGwZzWxcj54rZsvSdok https://cassyni.com/events/ApW8dLvtyKUTK1MSVJEB5P/seminar/qa https://cassyni.com/slides/outline/ApW8dLvtyKUTK1MSVJEB5P https://cassyni.com/events/ApW8dLvtyKUTK1MSVJEB5P/abstract https://cassyni-user-files-prod.s3.amazonaws.com/CP9DVtoARVGHfhV9j8ZB3L https://cassyni.com/events/ApW8dLvtyKUTK1MSVJEB5P?videoPreview=1 Structural defects in plants: key drivers of multi-scale performancenohttps://cassyni.com/events/ApW8dLvtyKUTK1MSVJEB5P?videoPreview=12026-06-17T10:55:00+00:001565.08NoneStructural defects, particularly kink bands, significantly influence the multi-scale performance and aging of plant fibers, with a focus on flax. These defects are plausibly induced during mechanical processing such as retting, scutching, or textile manufacturing, rather than during plant growth. Analysis using X-ray microtomography at Synchrotron Soleil revealed significant porosity, up to 20% in aged fibers, organized in an "onion peel" shape around the fiber lumen, correlating with cellulose layering. Second harmonic generation microscopy demonstrated substantial misorientation of crystalline cellulose within kink bands, ranging from 10 to 30 degrees, compared to 45-66 degrees in intact regions. Atomic force microscopy and Raman spectroscopy further indicated reduced longitudinal stiffness and crystallinity, respectively, in these damaged zones. Kink bands serve as critical sites for mechanical failure, with fiber fracture consistently occurring in these regions during tensile loading of both isolated fibers and flax composites. A correlation between kink band size and fiber Young's modulus has been observed, underscoring their detrimental impact on mechanical properties. Moreover, these defects act as entry points for biological colonization and accelerate polymer degradation, as evidenced by studies on ancient Egyptian flax textiles. Controlling mechanical processing parameters (e.g., pressure, time) is essential to minimize kink band formation and mitigate their negative effects on fiber properties, composite integrity, and long-term durability. Ongoing research explores potential methods for kink band recovery, including bleaching.https://cassyni-user-files-prod.s3.amazonaws.com/CP9DVtoARVGHfhV9j8ZB3L https://cassyni.com/slides/outline/Mgo3m1gL2kaeykssPQQJeq https://cassyni.com/events/Mgo3m1gL2kaeykssPQQJeq/abstract https://cassyni-user-files-prod.s3.amazonaws.com/VQXoS4BmhXQy24iVtDw62a https://cassyni.com/events/Mgo3m1gL2kaeykssPQQJeq?videoPreview=1 Quantum Rate Theory Applied to Redox Monolayers: Measuring the Electron Transfer Rate Without Free Parametersnohttps://cassyni.com/events/Mgo3m1gL2kaeykssPQQJeq?videoPreview=12026-06-17T16:00:00+00:003843.36Nanobionics Research GroupThis seminar validates Quantum Rate (QR) Theory by applying it to surface-confined redox monolayers. By using a ferrocene-tagged peptide platform, the research establishes a diffusionless electrochemical environment that enables direct extraction of kinetic rates without requiring empirical parameters. The theory centers on a master equation, where the degeneracy factor of four accounts for both electronic spin and the dynamic equilibrium between oxidation and reduction. The validation process relies on two primary methods: 1. Cyclic Voltammetry: By normalizing current to scan rate, the method isolates quantum capacitance at the reversible potential, directly providing the kinetic rate constant. 2. Electrochemical Impedance Spectroscopy: Converting impedance to complex capacitance spectra reveals quantum features in the complex plane, offering independent pathways to confirm the rate constant and providing a fundamental quantum explanation for charge-transfer resistance. Ultimately, this seminar demonstrates that classical models such as the Butler-Volmer model are specific Boltzmann limits of QR theory, and that tunneling decay parameters can be efficiently reverse-engineered from a single impedance dataset, thereby significantly simplifying characterization workflows.https://cassyni-user-files-prod.s3.amazonaws.com/VQXoS4BmhXQy24iVtDw62a https://cassyni.com/slides/outline/LhVqfePH9qUWK13sHRvyqw https://cassyni.com/events/LhVqfePH9qUWK13sHRvyqw/abstract https://cassyni-user-files-prod.s3.amazonaws.com/NmbJMcQaebMfybrhJa7P7C https://cassyni.com/events/LhVqfePH9qUWK13sHRvyqw?videoPreview=1 How Blockchain can transform the digital landscape in NZ and beyondnohttps://cassyni.com/events/LhVqfePH9qUWK13sHRvyqw?videoPreview=12021-11-19T06:00:00+00:001521.04Business SchoolNicole brings her fierce passion for smart and effective marketing communication to the role of CENNZnet General Manager. Combining a history of working across a broad range of technology disciplines, Nicole is on a crusade to ensure that Centrality is recognised globally as an edgy, market-leading and highly successful blockchain business.https://cassyni-user-files-prod.s3.amazonaws.com/NmbJMcQaebMfybrhJa7P7C https://cassyni.com/slides/outline/U7DuMu69jhnLoaaLFJniFw https://cassyni.com/events/U7DuMu69jhnLoaaLFJniFw/abstract https://cassyni-user-files-prod.s3.amazonaws.com/EqiMJ79kmPG6smTmx9HJNS https://cassyni.com/events/U7DuMu69jhnLoaaLFJniFw?videoPreview=1 MacMahon analysis view on Cylindric and Skew Shifted Partitionsnohttps://cassyni.com/events/U7DuMu69jhnLoaaLFJniFw?videoPreview=12026-07-13T14:00:00+00:003548.24The Journal of Algebraic CombinatoricsInteger partitions, their three-dimensional generalization, plane partitions, and its variants have been of interest to many. There have been some breakthroughs in cylindric partitions in the recent years, which made these objects to be looked at once again with fresh eyes and new techniques. I will share some new results on the cylindric partitions with 2 element profiles and skew double shifted plane partitions with 3 element profiles. This work is based on my recent collaborations with Runqiao Li.https://cassyni-user-files-prod.s3.amazonaws.com/EqiMJ79kmPG6smTmx9HJNS https://cassyni.com/slides/outline/V6X7TGPCcctVULQLMHG34q https://cassyni.com/events/V6X7TGPCcctVULQLMHG34q/abstract https://cassyni-user-files-prod.s3.amazonaws.com/28SP4wyHWFuAFfVm83c78z https://cassyni.com/events/V6X7TGPCcctVULQLMHG34q?videoPreview=1 When heat breaks photosynthesis: enzymes, diffusion, and the hidden bottlenecknohttps://cassyni.com/events/V6X7TGPCcctVULQLMHG34q?videoPreview=12026-06-03T07:30:00+00:00661.24Extreme heat is a major constraint on plant carbon assimilation, yet the processes that ultimately define the upper limits of photosynthesis remain incompletely resolved. Using the exceptional evolutionary diversity of the *Gossypium* genus, I investigate how photosynthetic performance is maintained under high temperature and compound heat and drought stress. Across multiple comparative experiments, including controlled temperature responses and simulated heatwave events (42°C for five days), substantial interspecific variation exists in the ability to sustain CO₂ assimilation under extreme heat. While species from hotter climates often possess Rubisco with superior high-temperature kinetics and more thermotolerant Rubisco activase, these biochemical advantages alone do not fully explain whole-leaf photosynthetic performance. Instead, recent evidence from temperature and drought experiments reveal that mesophyll conductance (gm) becomes a critical, temperature-sensitive bottleneck, constraining CO₂ delivery to Rubisco under extreme conditions. By integrating gas-exchange physiology, enzyme kinetics, and emerging insights into internal CO₂ diffusion, this work demonstrates that extending the thermal limits of photosynthesis requires coordinated optimisation of both biochemical capacity and CO₂ supply. These findings reposition mesophyll conductance as a key, yet underappreciated determinant of photosynthetic resilience to extreme heat, with implications for predicting plant responses to climate extremes and identifying new targets for crop improvement.https://cassyni-user-files-prod.s3.amazonaws.com/28SP4wyHWFuAFfVm83c78z https://cassyni.com/events/6sLvNWGas1y2fpbANkaa77/seminar/qa https://cassyni.com/slides/outline/6sLvNWGas1y2fpbANkaa77 https://cassyni.com/events/6sLvNWGas1y2fpbANkaa77/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Sntu8ZzpGqJeFRAStwGuTL https://cassyni.com/events/6sLvNWGas1y2fpbANkaa77?videoPreview=1 SDG 7 and SDG 12: Sustainable Manufacturing and Energy Efficiencynohttps://cassyni.com/events/6sLvNWGas1y2fpbANkaa77?videoPreview=12026-09-17T08:00:00+00:003201.4Springer Nature Sustainable Development Goals ProgrammeAchieving a sustainable industrial future requires transformative approaches that integrate resource-efficient manufacturing, clean energy systems, and technological innovation. As industries worldwide face growing pressure to reduce emissions while maintaining competitiveness, the convergence of sustainable manufacturing and energy efficiency has become a critical pathway toward advancing both SDG 7, (Affordable and Clean Energy), and SDG 12, (Responsible Consumption and Production). This webinar brings together leading experts to explore how advances in manufacturing processes, renewable energy integration, digital technologies, and circular economy strategies can accelerate industrial decarbonization. Discussions will examine opportunities for improving energy performance across production systems, leveraging AI and data-driven solutions to optimize resource use, and creating more resilient and sustainable industrial value chains. Through diverse perspectives spanning research, innovation, and real-world implementation, our panel of experts- **Natalia Hartono**, and **Julian Hunt** will highlight emerging trends, key challenges, and practical solutions for reducing industrial environmental impacts while supporting economic growth. Participants will gain insights into the role of clean energy technologies, circular production models, and cross-sector collaboration in shaping the next generation of sustainable industries. Participants will gain insights into the role of advanced manufacturing technologies, lifecycle-based design, circular value chains, and clean energy infrastructure in enabling the transition toward net-zero industry. The session will highlight both technological innovations and practical implementation challenges, offering perspectives from across engineering, energy systems, and sustainability research.https://cassyni-user-files-prod.s3.amazonaws.com/Sntu8ZzpGqJeFRAStwGuTL https://cassyni.com/slides/outline/7MzXRBv7JUX5fb83yBsNNR https://cassyni.com/events/7MzXRBv7JUX5fb83yBsNNR/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Q6hgrpiiw5aVijuN1g2i5U https://cassyni.com/events/7MzXRBv7JUX5fb83yBsNNR?videoPreview=1 Isoscopy and Quantum Coherence at Room Temperaturenohttps://cassyni.com/events/7MzXRBv7JUX5fb83yBsNNR?videoPreview=12026-07-01T12:00:00+00:005117.28Nanobionics Research GroupThis seminar in the Quantum Electrochemistry series introduces "Isoscopy," a new mesoscopic paradigm that explains how quantum coherence survives at room temperature (300 K) in wet electrochemical environments. The seminar resolves the anomaly of repeatedly observing the fundamental resistance quantum in fluctuating liquid electrolytes by demonstrating that the wet environment acts as an active thermodynamic stabilizer rather than a source of classical decoherence. By minimizing the Grand Canonical Potential, the ionic cloud reorganizes to perfectly match the junction's quantum capacitance, thereby establishing the isoscopic condition. This energetic balance creates a thermodynamic degeneracy and allows the system to operate exactly at the Heisenberg uncertainty limit. The theory is experimentally validated by a "solvent invariance" test, in which the resistance quantum remains universally locked near 12.9 kOhms across solvents with vastly different dielectric constants (DCM, ACN, and ACN/water). Finally, the seminar derives the "Bridge Identity" between conductance quantum and quantum capacitance, explicitly connecting the chemical electrodynamic rate and capacitance observables to the solid-state physicist's conductance quantum with zero free parameters.https://cassyni-user-files-prod.s3.amazonaws.com/Q6hgrpiiw5aVijuN1g2i5U https://cassyni.com/events/EH4z4kyTStGsAQ7dLdSJX7/seminar/qa https://cassyni.com/slides/outline/EH4z4kyTStGsAQ7dLdSJX7 https://cassyni.com/events/EH4z4kyTStGsAQ7dLdSJX7/abstract https://cassyni-user-files-prod.s3.amazonaws.com/dbLoz4uVaurDjfLozAQJJ https://cassyni.com/events/EH4z4kyTStGsAQ7dLdSJX7?videoPreview=1 The other 1%: Showcasing science and scientists from the Global South and indigenous communitiesnohttps://cassyni.com/events/EH4z4kyTStGsAQ7dLdSJX7?videoPreview=12026-08-06T15:00:00+00:003899.44Royal Society PublishingEleven countries make up 77% of submissions to _Proceedings B_, and these countries are all from the so-called Global North. We know that there are excellent scientists doing outstanding science outside of these eleven countries, so why aren’t we seeing more of it? The goal of this special feature is to showcase the excellent science from parts of the world that are underrepresented in _Proceedings B_ and the scientists doing the work. The scientists presenting in this seminar epitomize the 43 papers in this issue with their focus on global governance inequities, Traditional Ecological Knowledge, a focus on inclusion of local stakeholders, the impact of gene loss for conservation, and an emphasis on aquatic and terrestrial diversity in parts of the world that are less well studied. We hope that through this process there will be a growing recognition of the impactful science that has been overlooked in these underrepresented areas. Banner image: [Wikimedia Commons](https://commons.wikimedia.org/wiki/File:Blue_Marble_2002.png)https://cassyni-user-files-prod.s3.amazonaws.com/dbLoz4uVaurDjfLozAQJJ https://cassyni.com/slides/outline/FGPpGknPjAJjyde2jAr4xd https://cassyni.com/events/FGPpGknPjAJjyde2jAr4xd/abstract https://cassyni-user-files-prod.s3.amazonaws.com/6pnzupPPS48SqzRw2Q43ZG https://cassyni.com/events/FGPpGknPjAJjyde2jAr4xd?videoPreview=1 Michael Crommie Inverseminarnohttps://cassyni.com/events/FGPpGknPjAJjyde2jAr4xd?videoPreview=12025-06-22T08:00:00+00:005536.2In this 90-minute Inverse Seminar, viewers will witness UC Berkeley physicist Michael Crommie experiencing his own landmark papers through a unique reversed format where graduate students present his research back to him. Arriving unprepared, Crommie reveals the hidden stories behind his discoveries: accidental breakthroughs, multiple two-year failed projects never published, and the unacknowledged influences that shaped his work. Watch as this format transforms a typical virtual seminar into an engaging dialogue where all participants stay actively engaged, students ask bold questions, and Crommie spontaneously connects abstract physics concepts to simple chemistry in ways he's never articulated before—capturing the messy reality of how science actually unfolds.https://cassyni-user-files-prod.s3.amazonaws.com/6pnzupPPS48SqzRw2Q43ZG https://cassyni.com/events/QejvGNbFUDkjyroZvsG5Ts/abstract https://cassyni-user-files-prod.s3.amazonaws.com/AMAQuipCQgVg4fbkPtYwxA https://cassyni.com/events/W6M9ibU69PbYGJQZkQjtCu/seminar/qa https://cassyni.com/slides/outline/W6M9ibU69PbYGJQZkQjtCu https://cassyni.com/events/W6M9ibU69PbYGJQZkQjtCu/abstract https://cassyni-user-files-prod.s3.amazonaws.com/NbGntD6isRNrPLQ4QQQGg6 https://cassyni.com/events/W6M9ibU69PbYGJQZkQjtCu?videoPreview=1 Modern applications of geometric algebranohttps://cassyni.com/events/W6M9ibU69PbYGJQZkQjtCu?videoPreview=12026-09-24T11:00:00+00:003786.4Royal Society PublishingHypercomplex algebras are a consequent generalization of real and complex numbers, quaternions and Grassmann algebras. Of particular relevance in mathematics, physics and many engineering disciplines, including robotics, scientific computing, computer graphics, geometric modeling and deep learning etc., are William Kingdon Clifford’s geometric algebras. This theme issue brings together top-level geometric algebra experts to review recent developments in the field of geometric algebras, provide an overview of its modern applications, introduce cutting edge research and discuss the most promising future use of geometric algebra.https://cassyni-user-files-prod.s3.amazonaws.com/NbGntD6isRNrPLQ4QQQGg6 https://cassyni.com/events/CJXp7HR8VmuvmQKyscb5c1/abstract https://cassyni-user-files-prod.s3.amazonaws.com/QHZEGWtA3H2PJotnCuS47G https://cassyni.com/events/PBGh52QjzyqkmVQzNyAx4D/abstract https://cassyni-user-files-prod.s3.amazonaws.com/9TxzgBcnWDHu2dsC8GthTL https://cassyni.com/events/Cof16fpinNDNvCt5Gy7ney/abstract https://cassyni-user-files-prod.s3.amazonaws.com/BiXuvU77NDTfpjfzAKc7i6 https://cassyni.com/slides/outline/3SRogEdK9jpSooqCAXjST7 https://cassyni.com/events/3SRogEdK9jpSooqCAXjST7/abstract https://cassyni-user-files-prod.s3.amazonaws.com/SPbzQByswefx1EQnxF85ga https://cassyni.com/events/3SRogEdK9jpSooqCAXjST7?videoPreview=1 Startups to watch – Innovators of tomorrownohttps://cassyni.com/events/3SRogEdK9jpSooqCAXjST7?videoPreview=12025-01-15T12:00:00+00:003762.04Academic Publishing in EuropeSession: Startups to watch – Innovators of tomorrow Moderator: Sami Benchekroun (Morressier) Startup Judges: Sara Grimme, Jan Reichelt, Paul Peters, Sven Fund Startups: Audemic, Blueberg Paper, StudyStream, Syllahttps://cassyni-user-files-prod.s3.amazonaws.com/SPbzQByswefx1EQnxF85ga https://cassyni.com/events/QebohE1pTR87FAjiYBxY5b/abstract https://cassyni-user-files-prod.s3.amazonaws.com/BRALTLvowGemSycFJY9W4E https://cassyni.com/events/MC7pbhWvBw6qAHtMbJHLUd/seminar/qa https://cassyni.com/slides/outline/MC7pbhWvBw6qAHtMbJHLUd https://cassyni.com/events/MC7pbhWvBw6qAHtMbJHLUd/abstract https://cassyni-user-files-prod.s3.amazonaws.com/BCWsKV91JHyHp5EqRXZhMQ https://cassyni.com/events/MC7pbhWvBw6qAHtMbJHLUd?videoPreview=1 SDG 4: Unlocking Opportunities Through Inclusive Educationnohttps://cassyni.com/events/MC7pbhWvBw6qAHtMbJHLUd?videoPreview=12026-06-24T13:00:00+00:003991.12Springer Nature Sustainable Development Goals ProgrammeThe SDG 4 Working Group at Springer Nature is delighted to host a panel discussion featuring contributors to Inclusive and Equitable Education for All, edited by Richard Ingram and published by Palgrave Macmillan. Bringing together voices from academia, the charity sector, training providers, teachers, grassroots organisations and disability rights advocacy groups worldwide, the speakers will discuss their chapters and the real-world impact of their work in advancing SDG 4 through inclusive education. Bridging research and practice, the panel will situate key educational challenges within the broader agenda of sustainable development. It will show that inclusive and equitable education is not only an ethical imperative, but also a practical approach to improving outcomes for all learners, fostering more inclusive societies and addressing global challenges. https://cassyni-user-files-prod.s3.amazonaws.com/BCWsKV91JHyHp5EqRXZhMQ https://cassyni.com/events/S9UAc3xe4hMkY5NqX4VBcR/seminar/qa https://cassyni.com/slides/outline/S9UAc3xe4hMkY5NqX4VBcR https://cassyni.com/events/S9UAc3xe4hMkY5NqX4VBcR/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Hf2p2C3Dh1vtvQbLfcj5Q https://cassyni.com/events/S9UAc3xe4hMkY5NqX4VBcR?videoPreview=1 Recreating the Cell Damage after Mild Traumatic Brain Injury In Vitronohttps://cassyni.com/events/S9UAc3xe4hMkY5NqX4VBcR?videoPreview=12023-06-06T04:00:00+00:002407.2The Auckland Bioengineering InstituteTBI is brain damage due to an external force that negatively impacts brain function. Up to 90% of cases are in the mild severity range of TBI, known as mild TBI (mTBI), which includes concussion and sub-concussive impacts. A cell injury device (CID) based on a dielectric elastomer actuator (DEA) was developed to model mTBI via injuring cultured cells with mechanical stretching. The device was capable of producing mechanical strains up to 40% and by at least 20%, and 50 repeated insults in less than a minute, which faithfully mimicked mTBI impacts in vitro. Gene and protein expression analysis were performed on mechanically stimulated pericyte cell cultures, where key genes and proteins were quantified to measure the cell response to these mechanical insults. The results of this study demonstrated that the CIDs was a suitable tool for simulating mTBI as an in vitro stretch injury model, which was proficient to induce patient-specific responses to mechanical impacts.https://cassyni-user-files-prod.s3.amazonaws.com/Hf2p2C3Dh1vtvQbLfcj5Q https://cassyni.com/slides/outline/PCDrxRvshFLTn9mPnyxdLh https://cassyni.com/events/PCDrxRvshFLTn9mPnyxdLh/abstract https://cassyni-user-files-prod.s3.amazonaws.com/4CLGShKcW4fj5AFndwNecN https://cassyni.com/events/PCDrxRvshFLTn9mPnyxdLh?videoPreview=1 African microbiome data in BugSigDBnohttps://cassyni.com/events/PCDrxRvshFLTn9mPnyxdLh?videoPreview=12024-09-17T12:30:00+00:00263.0Microbiome Virtual International ForumThe complexity and diversity in microbiome research pose difficulties in consolidating and evaluating existing knowledge. BugSigDB, an open-source and open-science platform (https://bugsigdb.org) powered by the same technology as Wikipedia, is designed to address this issue through standardized recording of key methods and signatures in published microbiome literature. BugSigDB is maintained by a global network of hundreds of curators, including many from Africa, fostering a more comprehensive understanding of health and disease and encouraging more inclusive and impactful research results. Currently, BugSigDB includes microbiome data of 39 studies conducted in 18 African countries, out of a total of 1174 curated studies from 78 countries. The goal of the presented work is to increase the curation of microbiome studies involving African participants, thereby enriching the global dataset and ensuring that African data is adequately represented in microbiome research.https://cassyni-user-files-prod.s3.amazonaws.com/4CLGShKcW4fj5AFndwNecN https://cassyni.com/events/DKE9v8UVWjLQnA4xzrFpa9/seminar/qa https://cassyni.com/slides/outline/DKE9v8UVWjLQnA4xzrFpa9 https://cassyni.com/events/DKE9v8UVWjLQnA4xzrFpa9/abstract https://cassyni-user-files-prod.s3.amazonaws.com/BzZmq61aueCAwdTcAwyV1p https://cassyni.com/events/DKE9v8UVWjLQnA4xzrFpa9?videoPreview=1 Bounds on the spreading radius in droplet impact: the inviscid casenohttps://cassyni.com/events/DKE9v8UVWjLQnA4xzrFpa9?videoPreview=12024-10-01T10:00:00+00:002715.2Royal Society PublishingWe consider the classical problem of droplet impact and droplet spread on a smooth surface in the case of an ideal inviscid fluid. We revisit the rim–lamella model of Roisman et al. (Roisman et al. 2002 Proc. R. Soc. Lond. A 458, 1411–1430 (doi:10.1098/rspa.2001.0923)). This model comprises a system of ordinary differential equations (ODEs); we present a rigorous theoretical analysis of these ODEs, and derive upper and lower bounds for the maximum spreading radius. Both bounds possess a 𝑊⁢𝑒1/2 scaling behaviour, and by a sandwich result, the spreading radius itself also possesses this scaling. We demonstrate rigorously that the rim–lamella model is self-consistent: once a rim forms, its height will invariably exceed that of the lamella. We introduce a rational procedure to obtain initial conditions for the rim–lamella model. Our approach to solving the rim–lamella model gives predictions for the maximum droplet spread that are in close agreement with existing experimental studies and direct numerical simulations.https://cassyni-user-files-prod.s3.amazonaws.com/BzZmq61aueCAwdTcAwyV1p https://cassyni.com/slides/outline/SVW1HJg4b9B4WYiiR5U9b https://cassyni.com/events/SVW1HJg4b9B4WYiiR5U9b/abstract https://cassyni-user-files-prod.s3.amazonaws.com/77PW8iDiQvG6JDej7cnMyg https://cassyni.com/events/SVW1HJg4b9B4WYiiR5U9b?videoPreview=1 On the Musically Possiblenohttps://cassyni.com/events/SVW1HJg4b9B4WYiiR5U9b?videoPreview=12024-09-20T12:00:00+00:00884.32Hong Kong Baptist UniversityThis analysis explores the evolving boundaries of the musically possible, emphasizing their historical contingency shaped by technological, cultural, and institutional developments—from ancient notations and ritual flutes to contemporary digital interfaces and algorithmic systems. It critiques dominant AI approaches in music that prioritize automation and compositional sound generation within a “more of the same” paradigm, rooted in a narrow conception of music as fixed sound objects. The study highlights the epistemic role of musical instruments as both technological artifacts and carriers of music theory, arguing that current AI interfaces often reduce creative interaction to linear, transcriptive workflows, limiting co-creative potential. By contrast, it advocates for AI systems that support nonlinear, improvisational engagement, drawing on musical practice to rethink interface design. The limitations of generative AI are underscored, particularly its failure to fulfill promises of flexibility and malleability, often reinforcing monocultural stylistic repetition rather than fostering sonic diversity. The discourse situates music as an inherently artificial construct—an artifice of human sonic entanglement—and interrogates how AI’s servo-mechanical automation and generative models impact this nature. It challenges ontological essentialism by proposing a bottom-up focus on evolving musical practices and musicianship, especially as AI becomes ubiquitously embedded in creative processes. Finally, it envisions AI’s transformative potential less in generative composition than as a distributed, multi-agent cultural force reshaping collaborative performance and the social fabric of music-making.https://cassyni-user-files-prod.s3.amazonaws.com/77PW8iDiQvG6JDej7cnMyg https://cassyni.com/slides/outline/3ujXEhYJFsufRT2HG6z6sX https://cassyni.com/events/3ujXEhYJFsufRT2HG6z6sX/abstract https://cassyni-user-files-prod.s3.amazonaws.com/8VEaiqYta7Umz2Ao1PsKuY https://cassyni.com/events/3ujXEhYJFsufRT2HG6z6sX?videoPreview=1 Is It Ever All Right to Have Beliefs That Are Not Supported by Evidence?nohttps://cassyni.com/events/3ujXEhYJFsufRT2HG6z6sX?videoPreview=12023-03-18T12:00:00+00:007044.52Hong Kong Baptist UniversityThis seminar explored the philosophical question of whether it is justifiable to hold beliefs, particularly religious ones, without sufficient evidence. One perspective, drawing on William James's "The Will to Believe," argues that when evidence for or against a belief is unclear, individuals retain the right to choose between two risks: believing falsely or missing out on a truth. This position frames such a decision as a choice between two equally legitimate practical epistemologies, emphasizing that belief without evidence is only permissible when evidence is not actively contradictory and the belief is not immoral. James's later work, "The Varieties of Religious Experience," is noted for identifying some evidence supporting religious belief. Another approach proposes a conceptual scheme distinguishing between prudential and epistemic reasons for belief. Prudential reason is defined as doing something conducive to one's benefits or well-being, while epistemic reason involves belief supported by evidence that makes it more likely to be true. Conflicts can arise when prudential reasons suggest believing something for which there is no epistemic support, or vice versa. If both types of reasons are instrumental, their goals (practical benefit vs. truth) can be ranked to resolve conflict. However, if epistemic reason is non-instrumental, prudential and epistemic reasons may be incommensurable, rendering a belief both prudentially rational and epistemically irrational. A critique of James suggests his argument, when focused on truth-seeking, becomes primarily epistemic rather than purely prudential, and that believing without clear evidence to gain a chance at truth still carries the inherent risk of believing a falsehood or missing other truths.https://cassyni-user-files-prod.s3.amazonaws.com/8VEaiqYta7Umz2Ao1PsKuY https://cassyni.com/slides/outline/GFwdPniREKkXK8G6ETYq1f https://cassyni.com/events/GFwdPniREKkXK8G6ETYq1f/abstract https://cassyni-user-files-prod.s3.amazonaws.com/G8AXzvkGcoWqc7xobYBz4n https://cassyni.com/events/GFwdPniREKkXK8G6ETYq1f?videoPreview=1 How public relations creates shared-purposenohttps://cassyni.com/events/GFwdPniREKkXK8G6ETYq1f?videoPreview=12023-07-28T12:00:00+00:001897.48Hong Kong Baptist UniversityDiscover how organizations, particularly in New Zealand and Australia, integrate purpose into their operations and engage stakeholders to address societal issues, as illustrated through their compelling case study. Our speakers will delve into communication and management theories, showcasing the significance of the Creating Shared Value (CSV) framework in fostering a collective goal to enhance society while bringing value to all involved.https://cassyni-user-files-prod.s3.amazonaws.com/G8AXzvkGcoWqc7xobYBz4n https://cassyni.com/slides/outline/ApoytGbeQHfSvG1rdYZ32D https://cassyni.com/events/ApoytGbeQHfSvG1rdYZ32D/abstract https://cassyni-user-files-prod.s3.amazonaws.com/5j6U5qNATRian3mLzcVj8r https://cassyni.com/events/ApoytGbeQHfSvG1rdYZ32D?videoPreview=1 The Lawlessness of Law and Ordernohttps://cassyni.com/events/ApoytGbeQHfSvG1rdYZ32D?videoPreview=12019-12-21T12:00:00+00:001570.32Hong Kong Baptist UniversityThis seminar critically examines the inherent contradictions within the concept of "law and order," focusing on the context of recent political movements in Hong Kong. It challenges the assumption of law’s inherent legality, proposing instead that law must be actively "legalized" through institutional frameworks and processes. The analysis explores normative understandings of law, highlighting its relational function in mediating societal values and its integral role in upholding human rights, which necessitate responsive governance and a recognition of historical trauma. Applied to Hong Kong, the study suggests that governmental application of law, particularly in suppressing dissent, is characterized by high perceived obligation but notably low precision and delegation of authority, thereby granting an excessive "margin of appreciation" to enforcement agencies like the police. Furthermore, the discussion scrutinizes the "separation thesis," contrasting legal positivism with legal realism. Legal realism, which emphasizes the indeterminacy, contextuality, and interpretative nature of legal frameworks, is presented as a crucial lens for understanding how the maintenance of order can manifest as unlawful and for re-evaluating the unconditional obedience to law in relation to justice and morality. This approach advocates for interdisciplinary perspectives, including critical legal studies and cultural studies of law, to offer alternative insights into legal practice.https://cassyni-user-files-prod.s3.amazonaws.com/5j6U5qNATRian3mLzcVj8r https://cassyni.com/slides/outline/BKTavxFAqkDVv2YkDyqqHX https://cassyni.com/events/BKTavxFAqkDVv2YkDyqqHX/abstract https://cassyni-user-files-prod.s3.amazonaws.com/To3CBUsvauw7gwk6cMSoiN https://cassyni.com/events/BKTavxFAqkDVv2YkDyqqHX?videoPreview=1 Voices from Larung Gar: Shaping Tibetan Buddhism for the Twenty-First Centurynohttps://cassyni.com/events/BKTavxFAqkDVv2YkDyqqHX?videoPreview=12021-04-10T12:00:00+00:008583.88Hong Kong Baptist UniversityPanel 1: Larung Gar, Its Impact and Founding Figures featuring Anam Thubten, David Germano, and Antonio Terrone, moderated by Holly Gayley. Panel 2: Voices of Second Generation at Larung Gar on Buddhist engagement with animal rights, gender equality, and science, moderated by Michael Sheehy, with Padma 'tsho, Geoff Barstow, Sarah Jacoby, and Catherine Hardie.https://cassyni-user-files-prod.s3.amazonaws.com/To3CBUsvauw7gwk6cMSoiN https://cassyni.com/events/LhMj6Vor92qsaJz1tkdSTf/abstract https://cassyni-user-files-prod.s3.amazonaws.com/7KoyFZj1tb3V5dN9xkAtir https://cassyni.com/events/LhMj6Vor92qsaJz1tkdSTf?videoPreview=1 An Interview with Prof. Andrew Loke : Did the Resurrection of Jesus Happen?nohttps://cassyni.com/events/LhMj6Vor92qsaJz1tkdSTf?videoPreview=12025-04-16T12:00:00+00:002540.8Hong Kong Baptist UniversityAbstract not yet added.https://cassyni-user-files-prod.s3.amazonaws.com/7KoyFZj1tb3V5dN9xkAtir https://cassyni.com/slides/outline/MgewBs6u1wx2F4p1zj6mGZ https://cassyni.com/events/MgewBs6u1wx2F4p1zj6mGZ/abstract https://cassyni-user-files-prod.s3.amazonaws.com/KoB16ckhWqqF93cfrgBA4E https://cassyni.com/events/MgewBs6u1wx2F4p1zj6mGZ?videoPreview=1 Large-scale calligraphy performance at historic monumentnohttps://cassyni.com/events/MgewBs6u1wx2F4p1zj6mGZ?videoPreview=12022-09-15T12:00:00+00:00492.8Hong Kong Baptist UniversityThis series of public performance of Chinese calligraphy, entitled 'Ink dance at historic relics' has always been grounded in Chinese aesthetics, my passion for Chinese calligraphy and my physical strength. My work takes a critical view of such historical and cultural issues as conservation and revitalization of Hong Kong's heritage. Rendered in bold and forceful brushstrokes, my work endeavors to convey it's literary content in an artistically assertive manner. In 2009 this HKBU project of revitalizing the historic relic as its Academy of Visual Arts (AVA) was named an Honorable mention in UNESCO Asia-Pacific Heritage Awards for Culture Heritage Conservation. In this light, my artistic decision of executing the calligraphic couplet on a monumental scale is a celebration of the significance of the revitalized historic relic and its far-reaching educational impact. The huge couplets, hung on the façade of the two-storey building with colonnaded verandahs, creates an innovative fusion of the Colonial Neoclassical style of architecture and the traditional Chinese aesthetics of honesty and austerity in calligraphy. It is enormously satisfying to finish a huge work of calligraphy at a historic relic while at the same time enjoying the delightful ambience of interacting with the responsive audience during my performance.https://cassyni-user-files-prod.s3.amazonaws.com/KoB16ckhWqqF93cfrgBA4E https://cassyni.com/events/V6Nzt7ombpFrjeLUxbxVgZ/abstract https://cassyni-user-files-prod.s3.amazonaws.com/HwySfJFtYpMStWiC38C9DY https://cassyni.com/events/V6Nzt7ombpFrjeLUxbxVgZ?videoPreview=1 T02 Data Preprocessing in Orangenohttps://cassyni.com/events/V6Nzt7ombpFrjeLUxbxVgZ?videoPreview=12023-08-07T12:00:00+00:00510.12Hong Kong Baptist UniversityAbstract not yet added.https://cassyni-user-files-prod.s3.amazonaws.com/HwySfJFtYpMStWiC38C9DY https://cassyni.com/slides/outline/JE7hs5aDwk5PDNWTM4iojj https://cassyni.com/events/JE7hs5aDwk5PDNWTM4iojj/abstract https://cassyni-user-files-prod.s3.amazonaws.com/YM7V62cHMVV3LFLg9skG7G https://cassyni.com/events/JE7hs5aDwk5PDNWTM4iojj?videoPreview=1 Combine Sounds and Textgrids - Ep.10nohttps://cassyni.com/events/JE7hs5aDwk5PDNWTM4iojj?videoPreview=12021-06-09T12:00:00+00:00239.84Hong Kong Baptist UniversityPhonetic research often necessitates the integration of multiple distinct audio recordings and their associated acoustic-phonetic annotations for comprehensive analysis. This study presents a practical methodology for efficiently combining sound files and their corresponding TextGrids using Praat software. The process initiates with the concatenation of individual sound files, such as separate speech segments, into a single, continuous sound chain. This combined audio is then saved in a standard WAV file format for subsequent use. Concurrently, separately created TextGrids, each containing precise temporal and categorical annotations for an initial sound file, are concatenated to form a unified TextGrid chain. To ensure the integrity and accuracy of the combined data, both the newly created sound chain and TextGrid chain are loaded together for visual inspection and editing within the Praat interface. A crucial refinement step involves the identification and removal of an extraneous boundary that can arise within the concatenated TextGrid, thereby ensuring continuous and accurate annotation across the entire merged audio segment. The harmonised TextGrid chain, with its corrected annotations, is subsequently saved as a text file. This structured workflow provides an efficient and reliable approach to consolidating disparate phonetic data, streamlining data management and facilitating more extensive analytical possibilities for researchers working with segmented or diverse speech corpora.https://cassyni-user-files-prod.s3.amazonaws.com/YM7V62cHMVV3LFLg9skG7G https://cassyni.com/events/U75nnkWiiu9i4tWUrdVAsf/abstract https://cassyni-user-files-prod.s3.amazonaws.com/88WC2KjB7m5KiDhFLUwML2 https://cassyni.com/events/U75nnkWiiu9i4tWUrdVAsf?videoPreview=1 A Critique of Universalismnohttps://cassyni.com/events/U75nnkWiiu9i4tWUrdVAsf?videoPreview=12022-10-31T12:00:00+00:005449.8Hong Kong Baptist UniversityFr. James Dominic Rooney joins Philosophy for the People to discuss his recent critique of universalism from both a philosophical and theological perspective.https://cassyni-user-files-prod.s3.amazonaws.com/88WC2KjB7m5KiDhFLUwML2 https://cassyni.com/slides/outline/XZd27Y3Po72M6ap3WHs8QV https://cassyni.com/events/XZd27Y3Po72M6ap3WHs8QV/abstract https://cassyni-user-files-prod.s3.amazonaws.com/HSmNxhaqQfn1hYnb784jze https://cassyni.com/events/XZd27Y3Po72M6ap3WHs8QV?videoPreview=1 Hong Kong Spotlight by Art Baselnohttps://cassyni.com/events/XZd27Y3Po72M6ap3WHs8QV?videoPreview=12020-11-30T12:00:00+00:001019.92Hong Kong Baptist UniversityJoin Elaine Ng, editor and publisher of ArtAsiaPacific magazine for a video walk-through to discover an array of artworks, from oil paintings, sculptures, photographs to multimedia projects all under one roof.https://cassyni-user-files-prod.s3.amazonaws.com/HSmNxhaqQfn1hYnb784jze https://cassyni.com/events/7MrQr3LgHftSvu4CaWZpz9/abstract https://cassyni-user-files-prod.s3.amazonaws.com/4yvi5j1UdBu7Aoruj8hKCi https://cassyni.com/events/7MrQr3LgHftSvu4CaWZpz9?videoPreview=1 The Past, Present and Future of Cultural Diplomacy as an Academic Disciplinenohttps://cassyni.com/events/7MrQr3LgHftSvu4CaWZpz9?videoPreview=12022-06-02T12:00:00+00:004275.08Hong Kong Baptist UniversityAbstract not yet added.https://cassyni-user-files-prod.s3.amazonaws.com/4yvi5j1UdBu7Aoruj8hKCi https://cassyni.com/slides/outline/6sCooMh9rDLPw8XJz5H2iq https://cassyni.com/events/6sCooMh9rDLPw8XJz5H2iq/abstract https://cassyni-user-files-prod.s3.amazonaws.com/W1bKQNbGKnP7JCNPZR5by8 https://cassyni.com/events/6sCooMh9rDLPw8XJz5H2iq?videoPreview=1 COVID-19 and Metaphor: A Bilingual Study of Pandemic Metaphor in Hong Kong Public Discoursenohttps://cassyni.com/events/6sCooMh9rDLPw8XJz5H2iq?videoPreview=12021-11-04T12:00:00+00:005855.28Hong Kong Baptist UniversityThe COVID-19 epidemic has given rise to the publication of a vast number of documents in Hong Kong. A project designed to investigate metaphors about coronavirus as reflected in both English and Chinese texts published in the SAR has been running at HKBU since January 2021. As part of this a total of 44 documents relating to government, scientific research, literary writing and the press have been collated and analysed for their metaphorical content. Of these, it is articles from the press that tend to be richest in terms of both the number and the variety of the metaphorical expressions that they contain. Within certain texts, metaphorical expressions can occur in patterns that reflect an often complex metaphorical modelling of the topic. A great diversity of metaphorical expressions have been identified relating to experiential areas such as war and the military, language, the natural world, containers, racing against time, buildings, crime, the family, journeys and fire. Of these, it is the first three categories that account for the greatest number of metaphorical expressions by far. Writers talk about winning the battle against the disease and going to the front line to meet healthcare staff; the RNA of COVID-19 is presented as a transcript, and the virus is attributed with a proofreading mechanism; and the epidemic is variously described as a tempest and a continuous eruption in the community. At the same time, there seem to be clear differences between the English and Chinese sources in terms of the themes that occur most frequently. Taken together, these expressions bear witness to the way in which writers utilise many different aspects of human experience to talk about this unprecedented assault on our health, safety and way of life.https://cassyni-user-files-prod.s3.amazonaws.com/W1bKQNbGKnP7JCNPZR5by8 https://cassyni.com/slides/outline/vimLXDuTdoNY2oxyba2zh https://cassyni.com/events/vimLXDuTdoNY2oxyba2zh/abstract https://cassyni-user-files-prod.s3.amazonaws.com/84hCTtLEgToR9rfCL7444E https://cassyni.com/events/vimLXDuTdoNY2oxyba2zh?videoPreview=1 Violinist Patrick Yim — Interview & Performancenohttps://cassyni.com/events/vimLXDuTdoNY2oxyba2zh?videoPreview=12021-04-08T12:00:00+00:00652.28Hong Kong Baptist UniversityThe solo violin recital, "Virtuosity," developed for the Tai Kwun's Spotlight series, offers a comprehensive survey of the solo violin repertoire. The program encompasses historical cornerstones from Bach and Paganini to Eugène Ysaÿe and Maitong, alongside works by Kaija Saariaho and three newly commissioned pieces by Hong Kong composers. This selection aims to redefine the traditional concept of virtuosity, expanding beyond technical speed and difficulty to encompass the manipulation of tone color and timbre. Experimental techniques, such as varied bow positions (from bridge to fingerboard), the incorporation of unpitched noise, and extensive use of harmonics, are explored to achieve this expanded sonic palette, particularly evident in Saariaho's *Nocturne*. The recital is presented as a two-part event. The first night, on April 20th, features a traditional program performance. The second night, on April 21st, adopts an interactive format, focusing on the new compositions with direct engagement from their creators, allowing for in-depth discussion and the drawing of parallels between contemporary and historical works. This approach is informed by a background blending traditional conservatory training with a strong emphasis on contemporary music, including extensive collaboration with composers and commissioning new works since 2017. The project ultimately seeks to provide a deeper understanding of compositional perspectives within the solo violin genre.https://cassyni-user-files-prod.s3.amazonaws.com/84hCTtLEgToR9rfCL7444E https://cassyni.com/slides/outline/4R7KFkasAiYhcCGxrNjAhj https://cassyni.com/events/4R7KFkasAiYhcCGxrNjAhj/abstract https://cassyni-user-files-prod.s3.amazonaws.com/ABKueKqV7vz75gackFumQS https://cassyni.com/events/4R7KFkasAiYhcCGxrNjAhj?videoPreview=1 How the Heart Grows: From Multi-scale Data to a Multi-scale Modelnohttps://cassyni.com/events/4R7KFkasAiYhcCGxrNjAhj?videoPreview=12021-03-09T03:00:00+00:003414.92The Auckland Bioengineering InstituteThe heart is the first organ to form and the first to function during early development. Embryological heart development consists of a series of events believed to be highly conserved in vertebrates. Heart development begins with establishing the cardiac fields followed by a cardiac crescent formation at the embryonic midline. Fusion of the cardiac crescent results in linear heart tube formation. The straight heart tube then undergoes bending, elongation, twisting, and helical torsion to form a looped heart. The looping phase is then followed by septation and valve formation giving rise to a four-chambered heart in avians and mammals. The looping phase plays a central role in heart development. Successful looping is essential for proper alignment of the future cardiac chambers and tracts. Since aberrant looping results in various congenital heart diseases, cardiac looping has been studied for several decades by various disciplines. However, looping is a very complex process and, despite a great deal of experimental data and research, the underlying mechanisms controlling the looping phase are unclear. Although several hypotheses have been proposed for the looping process, none of them has yet been fully accepted or rejected. In this study, comprehensive experimental and computational workflows are successfully developed to investigate C-looping (the first phase of the entire looping process) using multi-scale and multi-disciplinary approaches. Overall, our results support the differential growth hypothesis of C-looping by providing further qualitative and quantitative evidence, also provide insights into new cellular features concerning the mechanism of C-looping. This study reveals the differential patterns of growth at both the cellular and tissue levels with a high spatial and temporal resolution, and shows how geometrical changes of C-looping at the tissue level are linked to growth features at the cellular level. The developed workflow also provides a sound basis for further investigation into new research questions regarding C-looping. Furthermore, we provide the first 3D datasets for the C-looping heart with cell to organism level information, including datasets of heart images and segmented myocardial cells within the heart. https://cassyni-user-files-prod.s3.amazonaws.com/ABKueKqV7vz75gackFumQS https://cassyni.com/slides/outline/LickEpzjGGXaCXagQrMJv9 https://cassyni.com/events/LickEpzjGGXaCXagQrMJv9/abstract https://cassyni-user-files-prod.s3.amazonaws.com/JjyPrVFh5FXe3SsFEw1Kci https://cassyni.com/events/LickEpzjGGXaCXagQrMJv9?videoPreview=1 Machine Learning Assisted Photonics: From Metasurface Design and Materials to Quantum Photonicsnohttps://cassyni.com/events/LickEpzjGGXaCXagQrMJv9?videoPreview=12021-04-14T14:00:00+00:004546.68MetaMATDiscovering unconventional optical designs via machine-learning promises to advance on-chip circuitry, imaging, sensing, energy, and quantum information technology. In this talk, photonic design approaches and emerging material platforms will be discussed showcasting emerging photonic materials, machine-learning-assisted topology optimization for thermophotovoltaic metasurface designs and machine-learning-enabled quantum optical measurements.https://cassyni-user-files-prod.s3.amazonaws.com/JjyPrVFh5FXe3SsFEw1Kci https://cassyni.com/slides/outline/SeK8T9DNKgPwEQYm2aEoaM https://cassyni.com/events/SeK8T9DNKgPwEQYm2aEoaM/abstract https://cassyni-user-files-prod.s3.amazonaws.com/PUB7yZ7tsotMPbmfTpfj5p https://cassyni.com/events/SeK8T9DNKgPwEQYm2aEoaM?videoPreview=1 An upper bound visualization of design trade-offs in adsorbent materials for gas separationsnohttps://cassyni.com/events/SeK8T9DNKgPwEQYm2aEoaM?videoPreview=12021-08-19T00:15:00+00:003356.52The MacDiarmid Institute for Advanced Materials and NanotechnologyHow good are your materials? This presentation answers that question for the field of gas separation, and the underpinning philosphy of our approach can be applied to any scientific materials field - including yours! The last 20 years has seen an explosion in the number of publications investigating porous solids for gas adsorption and separation. The combination of external drivers such as anthropogenic climate change and industrial efficiency has been coupled with discovery of new materials such as synthetic zeolites, metal–organic frameworks, covalent organic frameworks, and non-porous adsorbents. Numerous reviews catalogue these materials and their properties. However, the field lacks a unifying resource to visually compare and analyse materials properties with regard to their utility as a scientific advance and potential for industrial use. In the related field of membrane science, the ‘Robeson upper bound’ empirically describes the trade-off between gas permeability and selectivity and has become a ubiquitous tool for comparing membrane materials. In this article, we propose upper and lower bounds that empirically correlate the trade-offs encountered when designing adsorbent materials for gas separation, specifically: capacity, selectivity, and heat of adsorption. We apply bound visualizations to adsorbents studied for light alkene/alkane separations and highlight their use in identifying candidate materials for examination within process models and for guiding insights to the most effective materials design strategies. Furthermore, we note the limitations of upper and lower bound visualizations and provide links to a database resource for researchers to produce and download bound visualization plots. We anticipate that introducing bound visualizations to the field of adsorbents for gas separations will allow researchers to provide context for the importance of new materials discoveries, understand trade-offs in adsorbent design, and connect process engineers with candidate materials.https://cassyni-user-files-prod.s3.amazonaws.com/PUB7yZ7tsotMPbmfTpfj5p https://cassyni.com/slides/outline/V7e22Szej3wZMrw9UhgN93 https://cassyni.com/events/V7e22Szej3wZMrw9UhgN93/abstract https://cassyni-user-files-prod.s3.amazonaws.com/D4S5UjmVpQPf6y2viNtYWA https://cassyni.com/events/V7e22Szej3wZMrw9UhgN93?videoPreview=1 Metasurfaces for light shaping: a look into the past to better appreciate the present and futurenohttps://cassyni.com/events/V7e22Szej3wZMrw9UhgN93?videoPreview=12020-11-10T14:00:00+00:004059.4MetaMATIn integrated circuits, an important prerequisite for success is that every transistor can be driven or read independently, and nanotechnology is used to push the integration limit subject to that essential requirement. In dielectric metasurfaces for wavefront shaping, one aims to imprint spatially varying phases (or amplitudes, polarizations) on an incoming optical beam, and nanotechnology is used to spatially control the phase down to the subwavelength scale, as required for high numerical aperture focusing or imaging, beam steering over large angles, and computer-generated holography. Just like for integrated circuits, it is important that the phase can independently be controlled by adjacent nanostructures (or meta-atoms). This demanding requirement has marked the history of diffractive optics. I will review this history, evidence some fundamental limitations and introduce recent prospects in my group in relation to disordered metasurfaces.https://cassyni-user-files-prod.s3.amazonaws.com/D4S5UjmVpQPf6y2viNtYWA https://cassyni.com/slides/outline/wynUrQnasV5AFQdVhHuTB https://cassyni.com/events/wynUrQnasV5AFQdVhHuTB/abstract https://cassyni-user-files-prod.s3.amazonaws.com/4pjBbNxii8vS65jmBQYrF8 https://cassyni.com/events/wynUrQnasV5AFQdVhHuTB?videoPreview=1 Acoustic and elastic wave propagation in microstructured media with interfaces: homogenization, simulation and optimizationnohttps://cassyni.com/events/wynUrQnasV5AFQdVhHuTB?videoPreview=12021-11-16T14:00:00+00:005218.28MetaMATThe design of media at a microstructured scale allows to control wave propagation in a fine way and to obtain exotic effects at the macroscopic scale. Thanks to homogenization methods, the microstructure can be advantageously replaced, at the macro scale, by a homogeneous effective medium. Then, it raises the question of optimization tools in order to design the microstructure that allows to achieve a desired macroscopic effect. In this context, the consideration of interfaces (microstructured interfaces, imperfect interfaces) can lead to modifications in the homogenization methods, the numerical methods, or the optimization methods classically used. Two different cases of interfaces will be presented (PhD work, supervised by Cédric Bellis and Bruno Lombard): (i) Homogenization and optimization are first carried out for microstructured interfaces. The homogenization of a highly contrasted, and therefore resonant, microstructured interface is studied in the time-domain and leads to resonant jump conditions on an effective interface (coll: Kim Pham, Agnès Maurel, Jean-Jacques Marigo). The introduction of auxiliary variables allows to get a local evolution problem in time which is then solved numerically to perform time-domain simulations for the effective resonant meta-interface. Finally, the sensitivity of the effective non-resonant model to the geometry of the microstructure is determined using topological derivatives (coll: Rémi Cornaggia) in order to develop a topological optimization of the microstructure. (ii) Homogenization of solids with imperfect interfaces of the spring-mass type is then performed (coll: Raphaël Assier). The wavefields are approximated at low-frequency for possibly nonlinear cracks. An approximation of both the wavefields and the dispersion relation is also obtained at higher frequencies for a 1D array of linear cracks.https://cassyni-user-files-prod.s3.amazonaws.com/4pjBbNxii8vS65jmBQYrF8 https://cassyni.com/events/MDEjAt8NJN9u3pRAiihfYq/seminar/qa https://cassyni.com/slides/outline/MDEjAt8NJN9u3pRAiihfYq https://cassyni.com/events/MDEjAt8NJN9u3pRAiihfYq/abstract https://cassyni-user-files-prod.s3.amazonaws.com/WZQZuiu8MLvNcT3QSZHBZQ https://cassyni.com/events/MDEjAt8NJN9u3pRAiihfYq?videoPreview=1 Interface Capturing for Multiphase Flows in PyFRnohttps://cassyni.com/events/MDEjAt8NJN9u3pRAiihfYq?videoPreview=12021-09-09T14:00:00+00:002764.12PyFRSimulating multiphase flows requires capturing the sharp interface between different fluids. Carrying out such simulations using high-order methods is challenging due to the Gibbs phenomenon. The appearance of spurious oscillations in the vicinity of discontinuities and steep gradients makes it difficult to accurately resolve shocks and sharp interfaces. In this talk, an approach for interface capturing in PyFR using a preconditioned and localized phase-field model is presented. The accuracy of the interface normal vectors used in the phase-field model is improved by utilizing a preconditioning procedure based on the level set method with localized artificial viscosity stabilization. Kinematic numerical tests in 2D and 3D show that the developed approach significantly improves accuracy with little added computational effort, and yields better results when compared to similar methods. Dynamic interface capturing validation tests are carried out by coupling the proposed method to the entropically damped artificial compressibility method for solving the incompressible Navier–Stokes equations.https://cassyni-user-files-prod.s3.amazonaws.com/WZQZuiu8MLvNcT3QSZHBZQ https://cassyni.com/slides/outline/6PnbnNid8dYGjt8Ti4sw17 https://cassyni.com/events/6PnbnNid8dYGjt8Ti4sw17/abstract https://cassyni-user-files-prod.s3.amazonaws.com/CH5j6ELTz8LXBt5qunw1Dg https://cassyni.com/events/6PnbnNid8dYGjt8Ti4sw17?videoPreview=1 Bayesian Inverse Problemsnohttps://cassyni.com/events/6PnbnNid8dYGjt8Ti4sw17?videoPreview=12021-10-05T03:00:00+00:003182.28The Auckland Bioengineering InstituteMany problems in science and engineering consist of estimating some unknown parameters of a physical system from limited and noisy observations. In practical conditions, these problems are often unstable; hence, they should be treated in an appropriate framework in the theory of inverse problems. The regularisation framework for inverse problems is concerned with the stabilisation of unstable problems. In this framework, the unknown is taken as a deterministic multi-dimensional quantity and the observation error is taken to be unknown without any probabilistic structure. In the Bayesian framework for inverse problems, which is the focus of this talk, the unknown and observation error are explicitly taken and modelled as jointly distributed random variables. One of the advantages of the Bayesian framework is that it can quantify the uncertainty of a point estimate for the unknown, unlike the deterministic framework. This framework can be used for many interesting inverse problems. A couple of them will be discussed in this short talk. https://cassyni-user-files-prod.s3.amazonaws.com/CH5j6ELTz8LXBt5qunw1Dg https://cassyni.com/slides/outline/3vYaYxUzwLmjhitgFH5Zzu https://cassyni.com/events/3vYaYxUzwLmjhitgFH5Zzu/abstract https://cassyni-user-files-prod.s3.amazonaws.com/5tsoXqxkh9KnABeEMLFFcS https://cassyni.com/events/3vYaYxUzwLmjhitgFH5Zzu?videoPreview=1 Learning of pragmatic formulaic sequences through multimodal input: The role of genre and highlightingnohttps://cassyni.com/events/3vYaYxUzwLmjhitgFH5Zzu?videoPreview=12020-03-20T16:00:00+00:002395.0Linguistics and Applied Language StudiesFormulaic competence is one of the key aspects of mastering a foreign language and one of the most challenging. Our study explored two factors that could potentially contribute to successful learning of formulas. First, we investigated if the same pragmatic formulaic sequences presented in videos from two different genres, TED talks and Friends, are noticed and learnt differently. Secondly, we used highlighting to see if it helps learners to focus on the target expressions and leads to better learning. The results showed that both factors have an impact on learners’ performance and could be used for designing effective language instructions.https://cassyni-user-files-prod.s3.amazonaws.com/5tsoXqxkh9KnABeEMLFFcS https://cassyni.com/slides/outline/Aqd3CXYM5kXXCXtFcieW9b https://cassyni.com/events/Aqd3CXYM5kXXCXtFcieW9b/abstract https://cassyni-user-files-prod.s3.amazonaws.com/7ncosUqsLtEySnkDKXkHEN https://cassyni.com/events/Aqd3CXYM5kXXCXtFcieW9b?videoPreview=1 Large stochastic systems of interacting particlesnohttps://cassyni.com/events/Aqd3CXYM5kXXCXtFcieW9b?videoPreview=12020-11-23T15:00:00+00:004019.4Partial Differential Equations and ApplicationsI will present some recent results, obtained with D. Bresch and Z. Wang, on large stochastic many-particle or multi-agent systems. Because such systems are conceptually simple but exhibit a wide range of emerging macroscopic behaviors, they are now employed in a large variety of applications from Physics (plasmas, galaxy formation...) to the Biosciences, Economy, Social Sciences. The number of agents or particles is typically quite large, with 1020 - 1025 particles in many Physics settings for example and just as many equations.Analytical or numerical studies of such systems are potentially very complex leading to the key question as to whether it is possible to reduce this complexity, notably thanks to the notion of propagation of chaos(agents remaining almost uncorrelated). To derive this propagation of chaos, we have introduced a novel analytical method, which led to the resolution of two long - standing conjectures: The quantitative derivation of the 2 - dimensional incompressible Navier - Stokes system from the point vortices dynamics; The derivation of the mean - field limit for attractive singular interactions such as in the Keller - Segel model for chemotaxis and some Coulomb gases.https://cassyni-user-files-prod.s3.amazonaws.com/7ncosUqsLtEySnkDKXkHEN https://cassyni.com/slides/outline/EJBtdwauZKKw3veSU3rdbK https://cassyni.com/events/EJBtdwauZKKw3veSU3rdbK/abstract https://cassyni-user-files-prod.s3.amazonaws.com/DwjyS9ar3NJpwqCsiZNVpa https://cassyni.com/events/EJBtdwauZKKw3veSU3rdbK?videoPreview=1 WannierTools and its recent developmentsnohttps://cassyni.com/events/EJBtdwauZKKw3veSU3rdbK?videoPreview=12022-04-12T15:00:00+00:003336.52Computer Physics CommunicationsWannierTools is an open-source software to investigate novel topological materials. This code works in the tight-binding framework, which can be generated by another software package Wannier90 (Mostofi et al., 2008). It can help to classify the topological phase of a given material by calculating the Wilson loop, and can get the surface state spectrum, which is detected by angle resolved photoemission (ARPES) and in scanning tunneling microscopy (STM) experiments. It also identifies positions of Weyl/Dirac points and nodal line structures, calculates the Berry phase around a closed momentum loop and Berry curvature in a part of the Brillouin zone (BZ). Besides, WannierTools is also able to study band unfolding, Landau level spectrum, ordinary magnetoresistance, anomalous Hall effects and large scale simulations such as twisted 2D systems. https://cassyni-user-files-prod.s3.amazonaws.com/DwjyS9ar3NJpwqCsiZNVpa https://cassyni.com/slides/outline/QBBbgF3HjqKz3vLsGBZSMs https://cassyni.com/events/QBBbgF3HjqKz3vLsGBZSMs/abstract https://cassyni-user-files-prod.s3.amazonaws.com/6xPKLockNyHBu5Vp1pR1rN https://cassyni.com/events/QBBbgF3HjqKz3vLsGBZSMs?videoPreview=1 Metamaterials for concealment and scattering reduction in acoustics and elasticitynohttps://cassyni.com/events/QBBbgF3HjqKz3vLsGBZSMs?videoPreview=12022-03-08T14:00:00+00:006339.88MetaMATAvoiding detection from echolocation is one of the most interesting applications of acoustic metamaterials. Transformation Acoustics can be used to obtain perfect cloaking when a suitable mapping can be written, which is typically easy to find only for a restricted set of cases. In our work, we try to achieve scattering reduction and partial invisibility in a set of scenarios where practical feasibility is preventing perfect cloaking. First, we address the problem of underwater scattering reduction of elliptic obstacles, by applying suitable mapping defined in elliptical coordinates, which allow for practical realization and experimental testing of a non-axisymmetric, anisotropic pentamode near-cloak. Then, we approach the problem from a different perspective: specifically, we use PDE-constrained optimization aiming at cloaks obtained with isotropic materials only, which can be implemented with distributions of scatterers in the background fluid. The formulation of the optimization problem is done in such a way as to consider practical limits in the obtainable homogenized properties. In the same way of thinking i.e., isotropic materials are easier to implement than other exotic material distribution, we address elastic cloaking with isotropic materials, going back to Transformation Theories and exploiting conformal mapping, underlining the limits of applicability of such method to obtain cloak that works for Rayleigh waves. Finally, a different type of concealment can be conceived as being able to listen to what others say, without being listened to. This implies achieving nonreciprocal acoustic wave propagation. We derive the prescription for material properties that need to be implemented for non-reciprocal wave propagation of 2D cylindrical acoustic waves. https://cassyni-user-files-prod.s3.amazonaws.com/6xPKLockNyHBu5Vp1pR1rN https://cassyni.com/slides/outline/MhuxLCHn9BdisHQgWppdj3 https://cassyni.com/events/MhuxLCHn9BdisHQgWppdj3/abstract https://cassyni-user-files-prod.s3.amazonaws.com/FwPArwZqJ1oeKXLQ4Gto1Y https://cassyni.com/events/MhuxLCHn9BdisHQgWppdj3?videoPreview=1 Wall model for LES based on building-block flowsnohttps://cassyni.com/events/MhuxLCHn9BdisHQgWppdj3?videoPreview=12022-02-02T16:00:00+00:003404.6Department of Aeronautics A wall model for large-eddy simulation is proposed by devising the flow as a collection of building blocks, whose information enables the prediction of the stress as the wall. The core assumption of the model is that simple canonical flows (such as turbulent channel flows, boundary layers, pipes, ducts, speed bumps, etc) contain the essential flow physics to devise accurate models. Three types of building block units are used to train the model, namely, turbulent channel flows, turbulent ducts, and turbulent boundary layers with separation. The approach is implemented using two interconnected artificial neural networks: a classifier, which identifies the contribution of each building block in the flow; and a predictor, which estimates the wall stress via non-linear combinations of building-block units. The output of the model is accompanied by the confidence in the prediction. The latter aids the detection of areas where the model underperforms, such as flow regions that are not representative of the building blocks used to train the model. The model is validated in a realistic aircraft geometry from NASA Juncture Flow Experiment, which is representative of external aerodynamic applications with trailing-edge separation.https://cassyni-user-files-prod.s3.amazonaws.com/FwPArwZqJ1oeKXLQ4Gto1Y https://cassyni.com/slides/outline/GmYQKst5N3oKzUKmCAuhcZ https://cassyni.com/events/GmYQKst5N3oKzUKmCAuhcZ/abstract https://cassyni-user-files-prod.s3.amazonaws.com/yQQc27XGd6orrrA1S3DUr https://cassyni.com/events/GmYQKst5N3oKzUKmCAuhcZ?videoPreview=1 Sound-evoked plasticity differentiates tinnitus from non-tinnitus micenohttps://cassyni.com/events/GmYQKst5N3oKzUKmCAuhcZ?videoPreview=12025-08-12T09:00:00+00:001220.08Frontiers in NeuroscienceTinnitus is the perception of non-meaningful sound in the absence of external stimuli. Although tinnitus behavior in animal models is associated with altered central nervous system activity, it is not currently possible to identify tinnitus using neuronal activity alone. In the mouse inferior colliculus (IC), a subpopulation of neurons demonstrates a sustained increase in spontaneous activity after a long-duration sound (LDS). Here, we use the “LDS test” to reveal tinnitus-specific differences in sound-evoked plasticity through IC extracellular recordings and the auditory brainstem response (ABRLDS) in CBA/CaJ mice after sound exposure and behavioral tinnitus assessment. Sound-exposed mice showed stronger and shorter tone-evoked responses in the IC compared to unexposed controls, but these differences were not strong predictors of tinnitus. In contrast, in the LDS test, non-tinnitus mice had a significantly stronger suppression in tone-evoked spike rate compared to tinnitus and unexposed control mice. ABR peak amplitudes also revealed robust differences between tinnitus and non-tinnitus mice, with ABR peaks from non-tinnitus mice exhibiting significantly stronger suppression in the LDS test compared to tinnitus and control mice. No significant differences were seen between cohorts in ABR amplitude, latency, wave V:I ratio, wave V:III ratio, I-V intra-peak latency, and I-VI intra-peak latency. We found high-frequency tone stimuli better suited to reveal tinnitus-specific differences for both extracellular IC and ABR recordings. We successfully used the LDS test to demonstrate that tinnitus-specific differences in sound-evoked plasticity can be shown using both multi-unit near-field recordings in the IC and non-invasive far-field recordings, providing a foundation for future electrophysiological research into the causes and treatment of tinnitus.https://cassyni-user-files-prod.s3.amazonaws.com/yQQc27XGd6orrrA1S3DUr https://cassyni.com/slides/outline/LDwX5WqKRT3kP4bAckELjw https://cassyni.com/events/LDwX5WqKRT3kP4bAckELjw/abstract https://cassyni-user-files-prod.s3.amazonaws.com/MJAcDNXmcymRwuguCgnXaN https://cassyni.com/events/LDwX5WqKRT3kP4bAckELjw?videoPreview=1 12 Labours Seminar Series: Developing an implantable sensor for long term pressure monitoring within the bodynohttps://cassyni.com/events/LDwX5WqKRT3kP4bAckELjw?videoPreview=12022-05-04T00:00:00+00:003272.16Auckland Bioengineering InstituteNo abstracthttps://cassyni-user-files-prod.s3.amazonaws.com/MJAcDNXmcymRwuguCgnXaN https://cassyni.com/events/Ud236Ps1gxKEWa6fAqL1WM/abstract https://cassyni-user-files-prod.s3.amazonaws.com/P9kgVBBFYtMBhiJmkDWQpN https://cassyni.com/events/5QYdvGTM4SHV1eApM2W2tu/seminar/qa https://cassyni.com/events/5QYdvGTM4SHV1eApM2W2tu/abstract https://cassyni-user-files-prod.s3.amazonaws.com/AmmZuitNjQBJAAR2Sa1qgS https://cassyni.com/slides/outline/7snf9ggyFj3yNaeNtiQfcq https://cassyni.com/events/7snf9ggyFj3yNaeNtiQfcq/abstract https://cassyni-user-files-prod.s3.amazonaws.com/7ciNfxzXUDLDvDN8Hdzqx2 https://cassyni.com/events/7snf9ggyFj3yNaeNtiQfcq?videoPreview=1 The Thermal Signature of the Residual Foam in Breaking Wavesnohttps://cassyni.com/events/7snf9ggyFj3yNaeNtiQfcq?videoPreview=12022-04-12T10:40:00+00:002490.04Water WavesQuantifying energy dissipation due to wave breaking remains an essential but elusive goal for studying and modeling air-sea fluxes of heat, gas, and momentum. Previous observations have shown that lifetimes of bubble plumes and surface foam are directly related to the dissipated energy. Specifically, the foam decay time can be used to estimate the timescale of the subsurface bubble plume and the energy dissipated in the breaking process. A mitigating factor is that the foam decay time can be significantly affected by the surfactant concentration. We present an experimental investigation of a new technique that exploits the thermal signature of cooling foam to infer wave breaking dynamics. The experiments were conducted in a laboratory wave tank using artificial seawater with and without the addition of a surfactant. We show that the time from the start of the breaking process to the onset of cooling scales with the bubble plume decay time and the dissipated energy, and is not significantly affected by the presence of additional surfactants. We confirm observations from the field of the spatial variability of the temperature of foam generated by an individual breaking event, which has implications for inferring the spatial variability of bubble plume depth.https://cassyni-user-files-prod.s3.amazonaws.com/7ciNfxzXUDLDvDN8Hdzqx2 https://cassyni.com/slides/outline/4RFRpuAJBXBLLtLpF42i61 https://cassyni.com/events/4RFRpuAJBXBLLtLpF42i61/abstract https://cassyni-user-files-prod.s3.amazonaws.com/ADjZixQNk25TniWto6KmQS https://cassyni.com/events/4RFRpuAJBXBLLtLpF42i61?videoPreview=1 Implicational Tonoid Logics and Implicational Partial Galois Logicsnohttps://cassyni.com/events/4RFRpuAJBXBLLtLpF42i61?videoPreview=12022-03-16T11:40:00+00:006004.92Logica UniversalisImplicational Tonoid Logics: Algebraic and Relational Semantics This paper combines two classes of generalized logics, one ofwhich is the class of weakly implicative logics introduced by Cintula andthe other of which is the class of gaggle logics introduced by Dunn. Forthis purpose we introduce implicational tonoid logics. More precisely, wefirst define implicational tonoid logics in general and examine their rela-tion to weakly implicative logics. We then provide algebraic semanticsfor implicational tonoid logics. Finally, we consider relational semantics,called Routley–Meyer–style semantics, for finitary those logics. Implicational Partial Galois Logics: Relational Semantics Implicational tonoid logics and their relational semantics havebeen introduced by Yang and Dunn. This paper extends this investigationto implicational partial Galois logics. For this, we first define some impli-cational partial gaggle logics as special kinds of implicational tonoid logicscalled “implicational partial Galois logics.” Next, we provide Routley–Meyer-style relational semantics for finitary those logics.https://cassyni-user-files-prod.s3.amazonaws.com/ADjZixQNk25TniWto6KmQS https://cassyni.com/slides/outline/FHWiqwPqqbMosAAqrbGQ2q https://cassyni.com/events/FHWiqwPqqbMosAAqrbGQ2q/abstract https://cassyni-user-files-prod.s3.amazonaws.com/887rrCUptdMK1XNhSP8534 https://cassyni.com/events/FHWiqwPqqbMosAAqrbGQ2q?videoPreview=1 A Reinterpretation of the Semilattice Semantics with Applicationsnohttps://cassyni.com/events/FHWiqwPqqbMosAAqrbGQ2q?videoPreview=12021-08-11T10:40:00+00:003197.16Logica UniversalisIn the early 1970s, Alasdair Urquhart proposed a semilattice semantics for relevance logic which he provided with an influential informational interpretation. In this article, I propose a BHK-inspired reinterpretation of the semantics which is related to Kit Fine’s truthmaker semantics. I discuss and compare Urquhart’s and Fine’s semantics and show how simple modifications of Urquhart’s semantics can be used to characterize both full propositional intuitionistic logic and Jankov’s logic. I then present (quasi-)relevant companions for both of these systems. Finally, I provide sound and complete labelled sequent calculi for all of the systems discussed.https://cassyni-user-files-prod.s3.amazonaws.com/887rrCUptdMK1XNhSP8534 https://cassyni.com/slides/outline/NCcoc8y5PN3KWSrpWbmmp9 https://cassyni.com/events/NCcoc8y5PN3KWSrpWbmmp9/abstract https://cassyni-user-files-prod.s3.amazonaws.com/TcrsKn5Lvm3AF9YYZYnEer https://cassyni.com/events/NCcoc8y5PN3KWSrpWbmmp9?videoPreview=1 Quantum Escapades: From nanoconstrictions to black holesnohttps://cassyni.com/events/NCcoc8y5PN3KWSrpWbmmp9?videoPreview=12022-09-05T15:00:00+00:004691.88Annals of PhysicsTime and again, one encounters marvelous unifying physics that links phenomena from the most miniscule to astronomical scales. Universal phase transitions in magnets, superconductors, and the cosmos; simple harmonic motion from neutrinos to fluids to galaxies; defect and structure formation in the early Universe and in liquid Helium---to name just a few. Here, we explore how the inverted harmonic oscillator, the lesser known sister of the simple harmonic oscillator, offers fertile grounds for the same beautiful dynamics across scales and tantalizing ‘quantum escapades’. In its presence, deep parallels become manifest in quantum Hall systems, quantum optics, and curved spacetime. We journey through these parallels, linking phenomena as disparate as tunneling across point contacts, squeezing, Hawking-Unruh radiation, and black hole ringdown to offer fresh cross-disciplinary perspectives and new predictions. https://cassyni-user-files-prod.s3.amazonaws.com/TcrsKn5Lvm3AF9YYZYnEer https://cassyni.com/slides/outline/HG8m9JVpznWJ7M9UW84n61 https://cassyni.com/events/HG8m9JVpznWJ7M9UW84n61/abstract https://cassyni-user-files-prod.s3.amazonaws.com/9MzQpM2a9n7rLce86EbSaa https://cassyni.com/events/HG8m9JVpznWJ7M9UW84n61?videoPreview=1 Crystallography and Delaunay's Worknohttps://cassyni.com/events/HG8m9JVpznWJ7M9UW84n61?videoPreview=12021-02-27T16:30:00+00:00994.04Mathematical IntelligencerNo abstracthttps://cassyni-user-files-prod.s3.amazonaws.com/9MzQpM2a9n7rLce86EbSaa https://cassyni.com/slides/outline/KjNnNijTC5GnUHd33oyQow https://cassyni.com/events/KjNnNijTC5GnUHd33oyQow/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Hbe6K4QbghCiNYGLcvK2UW https://cassyni.com/events/KjNnNijTC5GnUHd33oyQow?videoPreview=1 Bessmertnyi Realizations, Representations, and Related Problems in Multiphase Compositesnohttps://cassyni.com/events/KjNnNijTC5GnUHd33oyQow?videoPreview=12022-07-19T13:00:00+00:004539.52MetaMATWe discuss multivariate functions that can be represented as the Schur complement of a linear (matrix-, tensor-, or operator-valued) pencil, i.e., the class of Bessmertnyi realizable functions. We motivate this by showing that for multiphase composites, both the effective operator in the theory of composites as well as the DtN map for an electrical network are in this class in which the associated linear pencil is of positive semidefinite type. This naturally leads to multivariate (matrix-, tensor-, or operator-valued) Herglotz-Nevanlinna functions in this class and several open problems in realizability theory. Next, we present Bessmertnyi realizations as the ``universal" state-space model/realization [compared to others common in electrical engineering (e.g., Kalman-type, Fornasini-Marchesini, Givone-Roesser) that are just a special cases of the Bessmertnyi realization]. Then we discuss our recent work (see doi:10.1007/s11785-021-01150-2 and doi:10.1016/j.laa.2021.06.007) on extensions of the Bessmertnyi realization theorem for multivariate rational functions, Schur complement algebra and operations, and their application in symmetric determinantal representations of polynomials. Finally, we will show how the latter relates to the open realization problems above. This is based on joint work with Anthony Stefan (Florida Institute of Technology).https://cassyni-user-files-prod.s3.amazonaws.com/Hbe6K4QbghCiNYGLcvK2UW https://cassyni.com/slides/outline/SeTF2HnoLV2Zy6ccRFYLxd https://cassyni.com/events/SeTF2HnoLV2Zy6ccRFYLxd/abstract https://cassyni-user-files-prod.s3.amazonaws.com/LvKMWw9EaWnD1oN36pPN1k https://cassyni.com/events/SeTF2HnoLV2Zy6ccRFYLxd?videoPreview=1 Satellites for Waternohttps://cassyni.com/events/SeTF2HnoLV2Zy6ccRFYLxd?videoPreview=12022-08-18T13:30:00+00:003723.76Nature WaterRemote sensing technologies, usually involving satellites, provide a unique gathering of information about the Earth’s water cycle. Join us for a conversation with Bridget Scanlon (UT Texas), Matthew Rodell (NASA) and Jida Wang (Kansas State University) about the role of satellite remote sensing in the monitoring of the state and evolution of our environment and management of freshwater resources. We will discuss earth missions (GRACE, GRACE-FO and SWOT), challenges, opportunities and strategies for using satellites to help address some of today’s water issues.https://cassyni-user-files-prod.s3.amazonaws.com/LvKMWw9EaWnD1oN36pPN1k https://cassyni.com/slides/outline/T96r4ySKmwacxs9W1gq9Dw https://cassyni.com/events/T96r4ySKmwacxs9W1gq9Dw/abstract https://cassyni-user-files-prod.s3.amazonaws.com/NKjMpDpH7BLPwNWp44VwFk https://cassyni.com/events/T96r4ySKmwacxs9W1gq9Dw?videoPreview=1 An Extended Paradefinite Logic Combining Conflation, Paraconsistent Negation, Classical Negation, and Classical Implication: How to Construct Nice Gentzen-type Sequent Calculinohttps://cassyni.com/events/T96r4ySKmwacxs9W1gq9Dw?videoPreview=12022-08-03T14:00:00+00:004523.44Logica UniversalisIn this study, an extended paradefinite logic with classical negation (EPLC), which has the connectives of conflation, paraconsistent negation, classical negation, and classical implication, is introduced as a Gentzen-type sequent calculus. The logic EPLC is regarded as a modification of Arieli, Avron, and Zamansky’s ideal four-valued paradefinite logic (4CC) and as an extension of De and Omori’s extended Belnap–Dunn logic with classical negation (BD+) and Avron’s self-extensional four-valued paradefinite logic (SE4). The completeness, cut-elimination, and decidability theorems for EPLC are proved and EPLC is shown to be embeddable into classical logic. The strong equivalence substitution property and the admissibilities of the rules of negative symmetry, contraposition, and involution are shown for EPLC. Some alternative simple Gentzen-type sequent calculi, which are theorem-equivalent to EPLC, are obtained via these characteristic properties.https://cassyni-user-files-prod.s3.amazonaws.com/NKjMpDpH7BLPwNWp44VwFk https://cassyni.com/events/BqND7y5aQSTJCvrgHn8u4R/abstract https://cassyni-user-files-prod.s3.amazonaws.com/MuNyQH7zD2szJMwaBxC6QE https://cassyni.com/slides/outline/Lj35xGj2JgRUPh2hhNRwPT https://cassyni.com/events/Lj35xGj2JgRUPh2hhNRwPT/abstract https://cassyni-user-files-prod.s3.amazonaws.com/46C769fBtKLEn4e2hXwE4E https://cassyni.com/events/Lj35xGj2JgRUPh2hhNRwPT?videoPreview=1 Ionizing radiation has negligible effects on the age, telomere length, and corticosterone levels of Chornobyl tree frogsnohttps://cassyni.com/events/Lj35xGj2JgRUPh2hhNRwPT?videoPreview=12024-11-08T12:00:00+00:002017.72Royal Society PublishingThe accident that occurred at Chornobyl nuclear power plant (Ukraine, 1986) contaminated a large extension of territory after the deposition of radioactive material. It is still under debate whether the chronic exposure to the radiation levels currently present in the area have long-term effects for organisms, such as decreases in longevity. Here, we investigate whether current levels of radiation in Chornobyl negatively impact the age of the Eastern tree frog Hyla orientalis. We also explore whether radiation induces changes in an ageing marker, telomere length, or in the stress hormone corticosterone. We found no effect of total individual absorbed radiation (including both external and internal exposure) on frog age (n = 197 individuals sampled in three consecutive years). We also did not find any relationship between individual absorbed radiation and telomere length, nor between individual absorbed radiation and corticosterone levels. Our results suggest that radiation levels currently experienced by Chornobyl tree frogs may not be high enough to cause severe chronic damage to semi-aquatic vertebrates such as this species. This is the first study addressing age and stress hormones in Chornobyl wildlife, and thus future research will confirm if these results can be extended to other taxa.https://cassyni-user-files-prod.s3.amazonaws.com/46C769fBtKLEn4e2hXwE4E https://cassyni.com/slides/outline/UdSNoqbJjND8hjYgTMQdyf https://cassyni.com/events/UdSNoqbJjND8hjYgTMQdyf/abstract https://cassyni-user-files-prod.s3.amazonaws.com/XezBeZZvRmQahmheH8a1yQ https://cassyni.com/events/UdSNoqbJjND8hjYgTMQdyf?videoPreview=1 Dynamics around the Earth–Moon triangular points in the Hill restricted 4-body problemnohttps://cassyni.com/events/UdSNoqbJjND8hjYgTMQdyf?videoPreview=12024-11-15T14:00:00+00:001555.48Celestial Mechanics and Dynamical AstronomyIn this talk, we give a review of the motion of a small particle moving near the triangular points (L4,5) of the Earth-Moon system subject to periodic forcing of the Sun modelled by the Hill restricted 4-body problem. We do this in several steps. First, we continue equilibria into periodic solutions in the perturbed problem, as well as resonant periodic solutions via subharmonic Melnikov methods. Then, we apply a center manifold reduction to limited effect. Given the limitations of the center manifold reduction, we apply a flow map method to compute five families of quasi-periodic invariant 2-tori around the two periodic orbits (one replacing L4 and a 2:1 resonant orbit) in the region. We compute their linear normal behavior and identify bifurcations. Mechanisms for transport between Earth, L4, and the Moon will be discussed.https://cassyni-user-files-prod.s3.amazonaws.com/XezBeZZvRmQahmheH8a1yQ https://cassyni.com/slides/outline/XbJNyJxZxkbwuxrjJufdLH https://cassyni.com/events/XbJNyJxZxkbwuxrjJufdLH/abstract https://cassyni-user-files-prod.s3.amazonaws.com/WfgyZCGsYrJLgaMCLxKEbx https://cassyni.com/events/XbJNyJxZxkbwuxrjJufdLH?videoPreview=1 Self-gravitational dynamics within the inner Oort cloudnohttps://cassyni.com/events/XbJNyJxZxkbwuxrjJufdLH?videoPreview=12024-11-15T14:00:00+00:001280.84Celestial Mechanics and Dynamical AstronomyThe formation of the Inner Oort Cloud (IOC)—a vast halo of icy bodies residing far beyond Neptune's orbit—is an expected outcome of the solar system's primordial evolution within a stellar cluster. Recent models have shown that the process of early planetesimal capture within the trans-Neptunian region may have been sufficiently high for the cumulative mass of the Cloud to approach several Earth masses. In light of this, here we examine the dynamical evolution of the IOC, driven by its own self-gravity. We show that the collective gravitational potential of the IOC is adequately approximated by the Miyamoto–Nagai model and use a semi-analytic framework to demonstrate that the resulting secular oscillations are akin to the von Zeipel–Lidov–Kozai resonance. We verify our results with direct N-body calculations and examine the effects of IOC self-gravity on the long-term behavior of the solar system's minor bodies using a detailed simulation. Cumulatively, we find that while the modulation of perihelion distances and inclinations can occur within an observationally relevant range, the associated timescales vastly surpass the age of the sun, indicating that the influence of IOC self-gravity on the architecture of the solar system is negligible.https://cassyni-user-files-prod.s3.amazonaws.com/WfgyZCGsYrJLgaMCLxKEbx https://cassyni.com/slides/outline/Kjo86ATkEVAgfT54LL43HF https://cassyni.com/events/Kjo86ATkEVAgfT54LL43HF/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Dva4EecP2kkJmYA99Wo57t https://cassyni.com/events/Kjo86ATkEVAgfT54LL43HF?videoPreview=1 Fecal microbiota transplantation alters the proteomic landscape of inflammation in HIV: identifying bacterial driversnohttps://cassyni.com/events/Kjo86ATkEVAgfT54LL43HF?videoPreview=12025-01-21T15:00:00+00:00746.04Microbiome Virtual International ForumBACKGROUND. Despite effective antiretroviral therapy, people with HIV (PWH) experience persistent systemic inflammation and increased morbidity and mortality. Modulating the gut microbiome through fecal microbiota transplantation (FMT) represents a novel therapeutic strategy. We aimed to evaluate proteomic changes in inflammatory pathways following repeated, low-dose FMT versus placebo. METHODS. This double-masked, placebo-controlled pilot study assessed the proteomic impacts of weekly FMT versus placebo treatment over 8 weeks on systemic inflammation in 29 PWH receiving stable antiretroviral therapy (ART). Three stool donors with high Faecalibacterium and butyrate profiles were selected, and their individual stools were used for FMT capsule preparation. Proteomic changes in 345 inflammatory proteins in plasma were quantified using the proximity extension assay, with samples collected at baseline and at weeks 1, 8, and 24. Concurrently, we characterized shifts in the gut microbiota composition and annotated functions through shotgun metagenomics. We fitted generalized additive models to evaluate the dynamics of protein expression. We selected the most relevant proteins to explore their correlations with microbiome composition and functionality over time using linear mixed models. RESULTS. FMT significantly reduced the plasma levels of 45 inflammatory proteins, including established mortality predictors such as IL6 and TNF-α. We found notable reductions persisting up to 16 weeks after the final FMT procedure, including in the expression of proteins such as CCL20 and CD22. We identified changes in 46 proteins, including decreases in FT3LG, IL6, IL10RB, IL12B, and IL17A, which correlated with multiple bacterial species. We found that specific bacterial species within the Ruminococcaceae, Succinivibrionaceae, Prevotellaceae families, and the Clostridium genus, in addition to their associated genes and functions, were significantly correlated with changes in inflammatory markers. CONCLUSIONS. Targeting the gut microbiome through FMT effectively decreased inflammatory proteins in PWH, with sustained effects. These findings suggest the potential of the microbiome as a therapeutic target to mitigate inflammation-related complications in this population, encouraging further research and development of microbiome-based interventions.https://cassyni-user-files-prod.s3.amazonaws.com/Dva4EecP2kkJmYA99Wo57t https://cassyni.com/events/4RfmYLtbDw5EY3nqXa7LZK/seminar/qa https://cassyni.com/slides/outline/4RfmYLtbDw5EY3nqXa7LZK https://cassyni.com/events/4RfmYLtbDw5EY3nqXa7LZK/abstract https://cassyni-user-files-prod.s3.amazonaws.com/7CouWqVnVXE9QETVkXHZgA https://cassyni.com/events/4RfmYLtbDw5EY3nqXa7LZK?videoPreview=1 DCTs, DSTs and transforms on path graphs: History and recent resultsnohttps://cassyni.com/events/4RfmYLtbDw5EY3nqXa7LZK?videoPreview=12025-02-13T13:00:00+00:003859.04Journal on Image and Video ProcessingSoon after turning 50, the DCT remains the dominant transform for image and video coding and by far the most popular among the family of discrete trigonometric transforms (DTTs), including the DCTs and DSTs. The connection between the DCT and eigendecompositions of path graphs has been known for at least 30 years, yet DTT extensions that leverage this graph interpretation have only emerged recently. In this talk, we provide an overview of the DCT and its connection to graphs and describe several recent graph-based extensions of the DCT having desirable properties. Among these extensions, we will describe graph-based transforms that are efficiently learnable from data, have computationally efficient implementations, or are optimized for perceptual and/or computational metrics (rather than mean squared error distortion). https://cassyni-user-files-prod.s3.amazonaws.com/7CouWqVnVXE9QETVkXHZgA https://cassyni.com/slides/outline/FHw4ZP88t1Fi4Kcs97M2W9 https://cassyni.com/events/FHw4ZP88t1Fi4Kcs97M2W9/abstract https://cassyni-user-files-prod.s3.amazonaws.com/5NHeQhjHNhkAZ9tRr3xusc https://cassyni.com/events/FHw4ZP88t1Fi4Kcs97M2W9?videoPreview=1 Total Quality Management In Academianohttps://cassyni.com/events/FHw4ZP88t1Fi4Kcs97M2W9?videoPreview=12023-04-20T03:00:00+00:006281.0UKRNIn order to ensure high quality outputs, many sectors do not focus on assessing carefully selected outputs but instead probe the day-to-day operations and procedures most critical to the quality and value of the work. Can we apply some of the methods of quality control used in manufacturing to research, for example to enhance reproducibility in certain disciplines? At the core of this approach, termed total quality management (TQM), is the proposition that if we take care of the process, the results will take care of themselves. This workshop will present pilots currently being conducted or set up at a range of UKRN institutions that are designed to explore this approach.https://cassyni-user-files-prod.s3.amazonaws.com/5NHeQhjHNhkAZ9tRr3xusc https://cassyni.com/events/HGZ6rkE83CQCJWbVne9QZK/abstract https://cassyni-user-files-prod.s3.amazonaws.com/3hiDqQyw1E5jxcDd2mU5in https://cassyni.com/events/T9XBnRAcpMUXA2bXJCumhF/abstract https://cassyni-user-files-prod.s3.amazonaws.com/GjbJeVsPdbvJN1HTKiDKgJ https://cassyni.com/events/SesajjX6NtvUAG4dhmcyRw/seminar/qa https://cassyni.com/slides/outline/SesajjX6NtvUAG4dhmcyRw https://cassyni.com/events/SesajjX6NtvUAG4dhmcyRw/abstract https://cassyni-user-files-prod.s3.amazonaws.com/JrCsHWv58GMEVH46GMFRWW https://cassyni.com/events/SesajjX6NtvUAG4dhmcyRw?videoPreview=1 The Future of Microbiome Medicine – An Editor’s Perspectivenohttps://cassyni.com/events/SesajjX6NtvUAG4dhmcyRw?videoPreview=12025-06-03T01:00:00+00:002357.32Microbiome Virtual International ForumThe microbiome field continues to grow at an exponential rate with sophisticated approaches that are pushing the frontiers of science and translating fast into clinical practice. The past year has witnessed sustained progress in microbiome research with a shift towards high quality mechanistic studies, Artificial Intelligence-Machine Learning approaches and clinical trials with microbiome therapeutics. However, there are TWO fundamental areas of research that have lagged behind and are in desperate need of resolution. The first is the comprehensive characterisation of the so-called “healthy microbiome”, and the second is the establishment of robust longitudinal clinical studies where the starting point, or baseline state, predates the development of the disease or condition. The advances in microbiome science over the past year are too numerous to mention and this lecture will offer an update on the most exciting stories so far! One particular area that has seen exciting recent progress is the greater understanding of the impact of diet on the microbiome and vice versa. A key publication has explored the signatures of vegan, vegetarian and omnivore diets and their relationships to health outcomes. This work reinforces how humans can shape their own gut microbiomes, and by extension their health, directly through simple dietary choices as well as more indirectly through agricultural and food production practices. Other work has shown how microbial transformation of dietary xenobiotics shapes the gut microbiome composition and explains why the same dietary compounds can have different effects on the microbiomes of different individuals. More work has looked at how the cardiometabolic benefits of certain diets (e.g., non-industrialised diets and African Heritage diets) are linked to microbiome modulation. The finding that species from the Oscillibacter genus are associated with decreased faecal and plasma cholesterol levels is noteworthy and offers the prospect of potential benefits for lipid homeostasis and cardiovascular, renal and metabolic health. This is the more exciting with the very recent discovery of the hormone Cholesin, which is capable of inhibiting cholesterol synthesis in the liver, leading to a reduction in circulating cholesterol levels. The lecture will also discuss recent advances in microbiome therapeutics and will conclude by discussing some of the recent guidelines related to microbiome research (e.g., establishing causality, use of pre-clinical models and therapeutic applications), development of live biotherapeutic products and microbiome testing in clinical practice. Finally, we will lay out a vision for the future of how microbiome medicine could be integrated into routine clinical practice. https://cassyni-user-files-prod.s3.amazonaws.com/JrCsHWv58GMEVH46GMFRWW https://cassyni.com/events/6Pu6EtnAk5FBKVLDtW2NJR/seminar/qa https://cassyni.com/slides/outline/6Pu6EtnAk5FBKVLDtW2NJR https://cassyni.com/events/6Pu6EtnAk5FBKVLDtW2NJR/abstract https://cassyni-user-files-prod.s3.amazonaws.com/We3LKtgeUg5pPhasUtgdnv https://cassyni.com/events/6Pu6EtnAk5FBKVLDtW2NJR?videoPreview=1 Arms race of physical defences: hooked trichomes of Macaranga ant-plants kill lycaenid caterpillars, but one specialist has a counter-defencenohttps://cassyni.com/events/6Pu6EtnAk5FBKVLDtW2NJR?videoPreview=12025-06-26T15:05:27+00:00876.08Royal Society PublishingThe coevolution of insects and chemical plant defences has been described as an arms race, but it is unclear whether physical plant defences can produce similar outcomes. Here, we report a previously unknown interaction from the mutualism between ants and *Macaranga* trees. Although *Macaranga* trees are well protected against herbivory by aggressive ants, caterpillars of the genus *Arhopala* (Lepidoptera: Lycaenidae) can feed on the leaves by appeasing the ants with nectar-like secretions. One ant-plant species, *M. trachyphylla*, bears hooked trichomes on its green surfaces. When placed on *M. trachyphylla* stems or petioles, *Arhopala* caterpillars associated with other *Macaranga* species (*A. major*, *A. dajagaka* and *A. zylda*) were quickly arrested by the sharp trichomes that pierced their cuticle, resulting in death by rapid blood loss and removal by ants. In striking contrast, *A. amphimuta* caterpillars, which occur naturally on *M. trachyphylla*, could easily walk over the hooked trichomes without any injury. As hooked trichomes are a novel trait within *Macaranga*, this interaction provides an example of de novo evolution of a physical plant defence, which in turn has been overcome by a specialist herbivore. Our study suggests that physical plant defences can lead to evolutionary arms races similar to those for chemical defences.https://cassyni-user-files-prod.s3.amazonaws.com/We3LKtgeUg5pPhasUtgdnv https://cassyni.com/events/GGsBAZifXEKWB1LFQ4njSM/abstract https://cassyni-user-files-prod.s3.amazonaws.com/MHZhHYZzspsHDFmWLNNtpN https://cassyni.com/events/LijEhM4GsiEUn8nSbHVkDT/abstract https://cassyni-user-files-prod.s3.amazonaws.com/RAsSyPTXDRERfBduFKCNmU https://cassyni.com/events/7NAG6y1Rie5SY9iciktgvy/abstract https://cassyni-user-files-prod.s3.amazonaws.com/LipBTwp1Ynja5t3uKXmAiJ https://cassyni.com/events/Bq4Ms3QpyUGJbNcRBhChtR/abstract https://cassyni-user-files-prod.s3.amazonaws.com/PnGXTecPx7X4UgCZxUo9SN https://cassyni.com/slides/outline/QBJ68m6qMH2tdXYdSchsfB https://cassyni.com/events/QBJ68m6qMH2tdXYdSchsfB/abstract https://cassyni-user-files-prod.s3.amazonaws.com/X8gwNaLAv8dv4gsyzRsALW https://cassyni.com/events/QBJ68m6qMH2tdXYdSchsfB?videoPreview=1 Exceptional fossils from Peru and an integrative phylogeny reconcile the evolutionary timing and mode of Gavialis and its kinnohttps://cassyni.com/events/QBJ68m6qMH2tdXYdSchsfB?videoPreview=12025-08-04T05:00:00+00:00954.76Royal Society PublishingThe acquisition of a long and slender snout (longirostry) resulted in extreme similar morphology across crocodylians and, therefore, raised a conflict between morphological and molecular phylogenetic hypotheses involving the longirostrine living gharials, Gavialis gangeticus and Tomistoma schlegelii. This discrepancy is not only topological but also concerns divergence time estimates for the crown clade Gavialidae, especially due to the inclusion of another longirostrine forms, ancient ‘thoracosaurs’—which introduces significant chronostratigraphic inconsistencies. To contribute to reconcile these contrasting lines of evidence, exceptionally preserved fossils of a new Miocene gavialid from Peru were included in a total-evidence Bayesian analysis. Our analysis integrates morphological, molecular, and chronostratigraphic data and incorporates most taxa of the largest adaptive radiation of gavialids, which occurred in the Cenozoic of South American and Caribbean (SAC). Our results demonstrate that including SAC taxa substantially increase divergence estimates for Gavialidae, surpassing those inferred from molecular data alone. The exceptional preservation of the new Peruvian fossils enabled character re-evaluation for gavialids and ‘thoracosaurs’, the latter recovered even outside Crocodylia and suggesting that longirostry resulted from independent evolution. These findings underscore the crucial role of SAC gavialids for understanding the morphological trajectory and phylogenetics of longirostrine crocodylians.https://cassyni-user-files-prod.s3.amazonaws.com/X8gwNaLAv8dv4gsyzRsALW https://cassyni.com/slides/outline/Uc4sCzLszgpXVukFkpYLDs https://cassyni.com/events/Uc4sCzLszgpXVukFkpYLDs/abstract https://cassyni-user-files-prod.s3.amazonaws.com/EsLsTHAdUeigPAcNmSsTiE https://cassyni.com/events/Uc4sCzLszgpXVukFkpYLDs?videoPreview=1 Plot twist: homologous recombination actually promotes the development of cancer!nohttps://cassyni.com/events/Uc4sCzLszgpXVukFkpYLDs?videoPreview=12025-10-10T15:00:00+00:002033.72OncogeneGenetic instability is a hallmark of cancer cells. Homologous recombination (HR) plays a pivotal role in maintaining genome stability through its DNA repair and replication fork escort functions. Therefore, HR is classified as a tumour suppressor pathway. Consistently, many HR genes are mutated in cancer, especially in hereditary breast and ovarian cancer. However, although RAD51 controls the central steps of HR, no RAD51 mutations are associated with cancer predisposition, constituting the “RAD51 paradox”. One of the potential explanations for the “RAD51 paradox” is that mutations affecting mediator/accessory genes (such as BRCA1 or BRCA2) in cancer result in the absence of RAD51 on damaged DNA, leaving access to alternative exclusively mutagenic repair processes, such as single-strand annealing (SSA) or alternative end-joining (A-EJ), which can rescue some cell viability but also increase genetic instability. This raises the question of whether cancer predisposition actually results from HR deficiency itself or from alternative, nonconservative repair pathways. One study assessing this question in a mouse model revealed that decreasing RAD51 HR activity without stimulating SSA or A-EJ in vivo not only does not favour tumorigenesis but rather protects against it. These data suggest that RAD51-controlled HR is not a tumour suppressor but rather favours tumour progression. Cancer cells are highly proliferative, actively replicating their genomes, and are therefore subjected to high replication stress; pathways enabling them to cope with this massive replication stress, such as HR, should help them survive and proliferate, contrary to the belief dogma that HR acts as a tumour suppressor pathway. We propose that HR/RAD51, through its essential role in overcoming replication stress, should facilitate cancer progression as soon as early pretumorigenic hyperplasia states that trigger an active replication program, challenging commonly accepted views.https://cassyni-user-files-prod.s3.amazonaws.com/EsLsTHAdUeigPAcNmSsTiE https://cassyni.com/events/2RjTsPZx8nPxnkWN5TTNFo/abstract https://cassyni-user-files-prod.s3.amazonaws.com/H8yUt6qesjZUnZMUGB8z4N https://cassyni.com/slides/outline/9LSq2mvn3W7D2cLRwURmQh https://cassyni.com/events/9LSq2mvn3W7D2cLRwURmQh/abstract https://cassyni-user-files-prod.s3.amazonaws.com/9gnVQfeuHALYYbyU3ZFeAr https://cassyni.com/events/9LSq2mvn3W7D2cLRwURmQh?videoPreview=1 Metagenomic analyses reveal E. coli-derived siderophores as potential signatures for breast cancernohttps://cassyni.com/events/9LSq2mvn3W7D2cLRwURmQh?videoPreview=12026-01-20T15:00:00+00:00550.52Microbiome Virtual International ForumBackground Breast cancer remains the leading cause of cancer-related mortality among women, highlighting the urgent need for novel insights into its biology. Recent evidence suggests the gut microbiome and its metabolites may play a role in breast cancer pathogenesis. This study investigates the gut microbiome and its predicted metabolite profiles in breast cancer patients to uncover potential mechanistic links. Methods Comprehensive metagenomic analyses were conducted on the gut microbiome of pre and postmenopausal breast cancer patients where microbial species were profiled through AMPHORA2 and metabolites were predicted through antiSMASH. Multivariate association analysis (MaAsLin2) was used to identify significant associations between specific microbial species, predicted metabolites, and breast cancer status. A custom ensemble machine learning classifier was developed to classify pre- and postmenopausal breast cancer cases and controls based on microbial and predicted metabolite features. Additionally, a synthetic microbiome dataset was generated through MIDASim to validate the reproducibility of the ML results. Furthermore, we proposed the underlying mechanism of E. coli-siderophore in breast cancer through literature and statistical support. Results Our analysis profiled 471 microbial species and predicted 40 key metabolites in the metagenomic data. Statistical analysis identified significant positive associations (p-value < 0.05) of E. coli, siderophore, and thiopeptide production, with breast cancer. The custom ensemble model achieved accuracy and AUC as high as 78% and 90%, respectively, in classifying pre and postmenopausal cases and controls. The high-ranking features, including E. coli, siderophore, and thiopeptide, supported the statistical findings and reinforced their biological relevance. Lastly, we propose a mechanistic model in which E. coli secretes siderophores under iron-limiting conditions, facilitating iron sequestration from the host, that can potentially promote angiogenesis and tumor progression. Conclusion Our findings suggest that microbial iron acquisition mechanisms could be critical in breast cancer pathophysiology. Further functional analyses are warranted to validate the proposed mechanisms and assess their therapeutic potential. This study highlights the gut microbiome and its predicted metabolites as promising targets for breast cancer treatment, offering new directions for research and clinical intervention."https://cassyni-user-files-prod.s3.amazonaws.com/9gnVQfeuHALYYbyU3ZFeAr https://cassyni.com/events/EGvsVcQ2S5eERi3mwx8m8q/abstract https://cassyni-user-files-prod.s3.amazonaws.com/8WSMGazCF9pGPhTcTZAqoC https://cassyni.com/slides/outline/Co4vhT17Knm7rBFeH3QWPw https://cassyni.com/events/Co4vhT17Knm7rBFeH3QWPw/abstract https://cassyni-user-files-prod.s3.amazonaws.com/aTN3Cy5qAKhxqAEgWJSGW https://cassyni.com/events/Co4vhT17Knm7rBFeH3QWPw?videoPreview=1 Assembly of the infant gut microbiome and resistome are linked to bacterial strains in mother’s milknohttps://cassyni.com/events/Co4vhT17Knm7rBFeH3QWPw?videoPreview=12026-04-21T00:30:00+00:00352.12Microbiome Virtual International ForumThe establishment of the gut microbiome in early life is critical for healthy infant development. Although human milk is recommended as sole nutrition for the infant, little is known about how variation in the milk microbiome shapes the microbial communities in the infant gut. Here, we quantified the similarity between the maternal milk and the infant gut microbiomes using 507 metagenomic samples collected from 195 mother-infant pairs at one, three, and six months postpartum. Microbial taxonomic overlap between milk and the infant gut was driven by Bifidobacterium longum, and infant microbiomes dominated by B. longum showed greater temporal stability than those dominated by other species. We identified numerous instances of strain sharing between milk and the infant gut, involving both commensal (e.g. B. longum) and pathobiont species (e.g. K. pneumoniae). Shared strains also included typically oral species such as S. salivarius and V. parvula, suggesting possible transmission from the infant’s oral cavity to the mother’s milk. At one month, the infant gut microbiome was enriched in biosynthetic pathways, suggesting that early colonisers might be more metabolically independent than those present at six months. Lastly, we observed significant overlap in antimicrobial resistance gene carriage within mother-infant pairs. Together, our results suggest that the human milk microbiome has an important role in the assembly, composition, and stability of the infant gut microbiome.https://cassyni-user-files-prod.s3.amazonaws.com/aTN3Cy5qAKhxqAEgWJSGW https://cassyni.com/events/DHgudW8kMtPShU68auks2d/abstract https://cassyni-user-files-prod.s3.amazonaws.com/EBQjnY7LzEFej6NUYVJv62 https://cassyni.com/slides/outline/TcX45xQrVXNkA7YMHhEEwf https://cassyni.com/events/TcX45xQrVXNkA7YMHhEEwf/abstract https://cassyni-user-files-prod.s3.amazonaws.com/JytWXdazoPygptE1ucPkNr https://cassyni.com/events/TcX45xQrVXNkA7YMHhEEwf?videoPreview=1 Haldane’s rule in the developing brain: X-linked and imprinted genes contribute to male-biased transgressive expression in hybrid micenohttps://cassyni.com/events/TcX45xQrVXNkA7YMHhEEwf?videoPreview=12026-05-22T12:00:00+00:001575.04Royal Society PublishingThe placenta and developing brains of eutherian mammals are intimately connected and enriched for imprinted gene (IG) expression. In hybrids, the placenta is a hotspot for genetic and epigenetic incompatibilities that preferentially affect males. Whether the hybrid brain is similarly affected is an open question. We evaluated the effects of hybridization and placental dysregulation on neural gene expression (embryonic, juvenile, adult) and behavior (juvenile, adult) in a cross between the house mouse (Mus m. domesticus) and Algerian mouse (M. spretus), in which transgressive expression of imprinted and X-linked genes is a prominent feature of undersized F1 male placentas. In hybrid hypothalamus, transgressive expression was mainly embryonic and highly male-biased. Although fewer genes were dysregulated in hybrid male embryonic hypothalamus relative to placenta, we infer a similar genetic architecture involving X-IG incompatibilities, and incompatibilities between IGs and autosomal interaction partners. Hybrids had heightened anxiety-like behaviors and reduced activity relative to parental species, with a tendency towards larger behavioral differences in adult males. As the first study to characterize the effects of interspecific hybridization on neural gene expression and behavior in a mammal, this work extends the scope of phenotypes impacted by intrinsic incompatibilities and demonstrates that the brain obeys Haldane’s rule.https://cassyni-user-files-prod.s3.amazonaws.com/JytWXdazoPygptE1ucPkNr https://cassyni.com/events/6NfhDC7B2CVCrMbeaeTbvu/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Uu4nV3EWQ4ERCqXRPjDsBL https://cassyni.com/events/LDQguZ3UmbSwZG6wXQuxhb/abstract https://cassyni-user-files-prod.s3.amazonaws.com/XdhjEsXQncZH3meomWeYW https://cassyni.com/slides/outline/9LawbvWD4JjqmJQHL9jJny https://cassyni.com/events/9LawbvWD4JjqmJQHL9jJny/abstract https://cassyni-user-files-prod.s3.amazonaws.com/FHpDXdFyoKZzZQYrmNCbjC https://cassyni.com/events/9LawbvWD4JjqmJQHL9jJny?videoPreview=1 Demographic noise induced patterns in space and timenohttps://cassyni.com/events/9LawbvWD4JjqmJQHL9jJny?videoPreview=12026-07-28T07:00:00+00:002308.0Physics ReportsPatterns in time and space spanning a wide range of scales abound in nature, from the circadian oscillations to epidemic cycles, from the skins patterns in zebras to the spatial structure of ecological habitats. For many of these systems, deterministic descriptions may necessitate fine tuning of parameters in order for patterns to form, in a way that is incompatible with their observed natural robustness. Furthermore, endogenous stochasticity such as that coming from fluctuations in small copy numbers of the interacting basic variables may be significant for these systems, in addition to external sources of noise that act as a macroscopic bias to deterministic, reproducible dynamics. Here we survey natural systems for which demographic noise has been shown to be important, and for which an individual-based description that is intrinsically stochastic is needed. This amounts to characterizing their microscopic dynamics via master equations, which return the probability for observing a system in a given state, at a given time. The application of perturbative expansions to obtain approximate analytical and numerical solutions of the master equations describing these specific systems, shows how the effects of demographic noise emerge in a perturbative fashion, and how endogenous stochasticity can be self-consistently amplified, yielding almost regular oscillations, termed quasi-cycles. These quasi-cycles appear for parameter values that lie outside the regions in parameter space where deterministic oscillations are predicted, thereby enhancing robustness. Thus, counter intuitively, noise can organize in regular quasi-periodic orbits, thereby building macroscopic order from microscopic disorder. This intriguing concept, introduced for the temporal domain, can be extended to the realm of spatial systems: demographic noise can seed the emergence of stochastic Turing patterns, which have been observed in systems ranging from developmental patterns, hallucinations to microbial biofilms. In this talk we illustrate this concept in detail by spatial pattern formation and synchronization of circadian clocks in the filamentous multicellular cyanobacterial organism <em>Anabaena</em>. We highlight the constructive role that demographic noise can play in seeding stochastic self-organized patterns in specific systems, both in time and space.https://cassyni-user-files-prod.s3.amazonaws.com/FHpDXdFyoKZzZQYrmNCbjC https://cassyni.com/events/NBVu2xMdGvzFcvL1PBMSjw/abstract https://cassyni-user-files-prod.s3.amazonaws.com/P1qakpKvCK8APN6MRJxYr2 https://cassyni.com/events/4tokR2iFuuc6GpoWujjMC1/abstract https://cassyni-user-files-prod.s3.amazonaws.com/UQqqAcdgfEsM6ANzxjaoFL https://cassyni.com/slides/outline/BLgyxevAZcyUPAHKXqQbf3 https://cassyni.com/events/BLgyxevAZcyUPAHKXqQbf3/abstract https://cassyni-user-files-prod.s3.amazonaws.com/4gpAGtm37FeVU1baVVauRx https://cassyni.com/events/BLgyxevAZcyUPAHKXqQbf3?videoPreview=1 Differences in metagenome coverage may confound abundance-based and diversity conclusionsnohttps://cassyni.com/events/BLgyxevAZcyUPAHKXqQbf3?videoPreview=12024-11-12T15:00:00+00:00615.72Microbiome Virtual International ForumAlthough the importance of rarefying 16S rRNA gene data to the same coverage for reliable comparisons of diversity between samples has been well appreciated, the impact of (shotgun) metagenome coverage (i.e., what fraction of diversity was sequenced) on biological conclusions is commonly overlooked. We demonstrate that uneven coverage can lead to misleading conclusions about which features (e.g., genes, genomes) may differentiate two metagenomes or their diversity comparisons. We outline an approach to minimize this impact.https://cassyni-user-files-prod.s3.amazonaws.com/4gpAGtm37FeVU1baVVauRx