https://cassyni.com/slides/outline/MaapPFHacewLaAuVg2trJR https://cassyni.com/events/MaapPFHacewLaAuVg2trJR/abstract https://cassyni-user-files-prod.s3.amazonaws.com/M7QsvfJpzVyUbGDeXRqw5Y https://cassyni.com/events/MaapPFHacewLaAuVg2trJR?videoPreview=1 Organic Synthesis in Latin Americanohttps://cassyni.com/events/MaapPFHacewLaAuVg2trJR?videoPreview=12022-04-27T17:00:00+00:007767.68Thieme GroupLatin America is making great contributions to the field of organic synthesis and has a growing community of young researchers. Over the past few years, there has been significant growth in the development of synthetic methodologies as well as catalysis and natural products.https://cassyni-user-files-prod.s3.amazonaws.com/M7QsvfJpzVyUbGDeXRqw5Y https://cassyni.com/events/7FeBUGwvsaF8XK5ps94Ndj/seminar/qa https://cassyni.com/slides/outline/7FeBUGwvsaF8XK5ps94Ndj https://cassyni.com/events/7FeBUGwvsaF8XK5ps94Ndj/abstract https://cassyni-user-files-prod.s3.amazonaws.com/RXEsArGzi61ozKZtbbh5ta https://cassyni.com/events/7FeBUGwvsaF8XK5ps94Ndj?videoPreview=1 Realistic Hydrogen-based Solutions for Sustainable Aviationnohttps://cassyni.com/events/7FeBUGwvsaF8XK5ps94Ndj?videoPreview=12023-07-04T11:00:00+00:003345.28Brahmal Vasudevan Institute for Sustainable AviationAirlines, aircraft manufacturers and propulsion solution providers are all under significant pressure from consumers, investors, and customers to reduce emissions and provide zero carbon emission flight. There is growing consensus that hydrogen as an energy source will play a key role in transforming aviation into a zero-carbon system over the next few decades. McKinsey & Company found that “hydrogen – as a primary energy source for propulsion, either for fuel cells, direct burn in thermal (gas turbine) engines or as a building block for synthetic liquid fuels – could feasibly power aircraft with entry into service by 2035 for short-range aircraft.” In this presentation, I will discuss a hydrogen fuel cell-electric motor-propeller driven regional aircraft that is currently under development for introduction into service in 2025 and show how regional aircraft powered by green hydrogen are economically competitive on a cost per available seat-mile (CASM) basis with carbon-based fueled aircraft when the novel hydrogen storage and distribution system is employed. I will also discuss the fundamental challenges with using fuel cell-electric propulsion on larger aircraft, as well as the aircraft and propulsion system characteristics that ultimately determine the need to transition to direct combustion of hydrogen.https://cassyni-user-files-prod.s3.amazonaws.com/RXEsArGzi61ozKZtbbh5ta https://cassyni.com/events/UVYnaJHP9czDUmXcwN6ghT/seminar/qa https://cassyni.com/slides/outline/UVYnaJHP9czDUmXcwN6ghT https://cassyni.com/events/UVYnaJHP9czDUmXcwN6ghT/abstract https://cassyni-user-files-prod.s3.amazonaws.com/84Ck9xpzKP8PYyC8KJP7SW https://cassyni.com/events/UVYnaJHP9czDUmXcwN6ghT?videoPreview=1 Spotlight On...Research Integritynohttps://cassyni.com/events/UVYnaJHP9czDUmXcwN6ghT?videoPreview=12023-07-13T08:00:00+00:002520.56Topics at the heart of our communityAll stakeholders in the publishing process have a responsibility towards ensuring quality and integrity in scholarship. Join Chris Graf - Research Integrity Director - as he discusses Springer Nature’s world-leading research integrity team, as well as resources available to our editorial partners to guide your own comprehensive research integrity plans.https://cassyni-user-files-prod.s3.amazonaws.com/84Ck9xpzKP8PYyC8KJP7SW https://cassyni.com/slides/outline/Xx7e1iKwdBndLTsekXv9NM https://cassyni.com/events/Xx7e1iKwdBndLTsekXv9NM/abstract https://cassyni-user-files-prod.s3.amazonaws.com/JW1fM3FEWKK1ZPVJXYPuTC https://cassyni.com/events/Xx7e1iKwdBndLTsekXv9NM?videoPreview=1 Acceleration of Cyclostationary Signal Processing Algorithmsnohttps://cassyni.com/events/Xx7e1iKwdBndLTsekXv9NM?videoPreview=12023-09-11T10:30:00+00:001410.56HiPEDS CentreA time series is said to be cyclostationary if its probability distribution varies periodically with time. Cyclostationary time series analyses are suitable for a wide range of periodic phenomena in signal processing, including characterization of modulation types; noise analysis of periodic time-variant linear systems; synchronization problems; parameter and waveform estimation; channel identification and equalization; signal detection and classification; AR and ARMA modelling and prediction; and source separation In this talk we will discuss our recent research efforts to accelerate the estimation of the spectral correlation density through low-precision arithmetic, improved algorithms and bespoke hardware. For large input lengths, which are of interest in low signal-to-noise conditions, greater than 10x acceleration can be achieved using sparse techniques.https://cassyni-user-files-prod.s3.amazonaws.com/JW1fM3FEWKK1ZPVJXYPuTC https://cassyni.com/events/SWyzWCDAo9hYwbdR9cvMNu/seminar/qa https://cassyni.com/slides/outline/SWyzWCDAo9hYwbdR9cvMNu https://cassyni.com/events/SWyzWCDAo9hYwbdR9cvMNu/abstract https://cassyni-user-files-prod.s3.amazonaws.com/3vkDB5eDFZMw2t8Q5u9sUz https://cassyni.com/events/SWyzWCDAo9hYwbdR9cvMNu?videoPreview=1 First-principles theory of electrochemical capacitancenohttps://cassyni.com/events/SWyzWCDAo9hYwbdR9cvMNu?videoPreview=12023-11-07T14:00:00+00:004305.12Electrochimica ActaUnderstanding and interpreting electrochemical capacitance has advanced both theory and experiment in electrochemistry for more than a century. From a theoretical perspective, the interfacial capacitance is commonly defined based on the original notion of the interfacial Galvani potential, i.e., the inner electric potential difference between electrode and electrolyte phases. With the emergence of accurate first-principles methods, the atomistic simulation of the capacitive properties of electrochemical systems is gaining significant attention. At the atomistic level, however, the classical picture of inner potentials becomes questionable and new concepts are required, e.g., to explain electronic ‘quantum’ contributions to the capacitance of low-dimensional electrodes. In this seminar talk, I will present a new approach to describe electrochemical capacitance based on multicomponent density functional theory (MCDFT), which is a general formalism to treat multicomponent systems including electrons and ions/nuclei from first principles. It will be shown that MCDFT provides the conceptual framework needed to formulate a “modern” theory of electrochemical capacitance, connecting classical concepts of double-layer capacitance, quantum capacitance, and, eventually, reactive (pseudo)capacitance contributions. The formalism yields exact analytical expressions for the total capacitance incorporating electric and non-electric capacitance contributions. In the bulk limit of extended electrode and electrolyte phases, it is shown to reduce to the known classical expressions, providing firm basis for the classical approach based on the concept of Galvani potentials. Future opportunities towards a modern theory of capacitance will be discussed.https://cassyni-user-files-prod.s3.amazonaws.com/3vkDB5eDFZMw2t8Q5u9sUz https://cassyni.com/slides/outline/T1dbYsrhEcFbwNAJk4D9eD https://cassyni.com/events/T1dbYsrhEcFbwNAJk4D9eD/abstract https://cassyni-user-files-prod.s3.amazonaws.com/KujSrhfBMjbpap6tSDGvAi https://cassyni.com/events/2KDPEhWTHiZemusaDqd3xZ/seminar/qa https://cassyni.com/slides/outline/2KDPEhWTHiZemusaDqd3xZ https://cassyni.com/events/2KDPEhWTHiZemusaDqd3xZ/abstract https://cassyni-user-files-prod.s3.amazonaws.com/9UJEp7rU5UZNiT2mmBhz8e https://cassyni.com/events/2KDPEhWTHiZemusaDqd3xZ?videoPreview=1 Fate and transport of microplastics at water recycling plantsnohttps://cassyni.com/events/2KDPEhWTHiZemusaDqd3xZ?videoPreview=12023-11-01T08:00:00+00:004513.28ElsevierMicroplastic pollution is a growing global concern for environmental and public health. Water Recycling Plants (WRPs) are a significant pathway for microplastics (MP) to enter the environment. However, existing WRPs are not specifically designed to manage microplastic pollution. Water utilities generally have limited or no experience in sampling and analysing MPs. There was also no knowledge about the efficiency of lagoon-based WRPs in removing MPs. In Australia, 60% of more than 1,200 WRPs use pond/lagoon as the primary treatment step, while 77% use ponds as one of the treatment steps. Additionally, there is very limited understanding of seasonal variation of MPs in WRPs influent. As the first long-term MP study at WRPs, this research investigated the fate and transport of MPs in three Australian WRPs via a 2-year study, covering different treatment scenarios used by the water industry. Our study allowed water utilities to gain a first experience in sampling and characterising MPs. It identified that different treatment systems can all achieve promising removal of MPs (>97%). A seasonal variation of MPs concentration was also found, which was most likely related to stormwater events in the catchment. A multimedia model was established to help water utilities to predict MPs behaviours and enhance their removal. The results highlighted the potential of low-cost/low-energy lagoon-based WRPs for MP control. The new knowledge addresses water industry key knowledge gaps, helps water utilities to successfully manage MPs in WRPs, mitigates microplastic pollution risks in the environment, and addresses community’s concerns.https://cassyni-user-files-prod.s3.amazonaws.com/9UJEp7rU5UZNiT2mmBhz8e https://cassyni.com/events/MaShp6i9brJhqUqeHMbJv9/abstract https://cassyni-user-files-prod.s3.amazonaws.com/8qJFYYEUyQ1GzWbADRVQyL https://cassyni.com/slides/outline/J7uUVKBUXeS4onY5dhDMPK https://cassyni.com/events/J7uUVKBUXeS4onY5dhDMPK/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Hpnfd5wVEadD5bL6gccbze https://cassyni.com/events/J7uUVKBUXeS4onY5dhDMPK?videoPreview=1 Turbulence: Reynolds Averaged Navier Stokes (RANS) Equations (Part 2, Momentum Equation)nohttps://cassyni.com/events/J7uUVKBUXeS4onY5dhDMPK?videoPreview=12021-04-16T12:00:00+00:001221.48Brunton LabTo model the bulk properties of a turbulent fluid flow, we often expand the velocity field into an average and a fluctuating component, substitute into the Navier-Stokes equations, and then average the equations in time. This video describes how to derive the Reynolds averaged Navier-Stokes (RANS) equations, which are widely used for turbulence modeling in engineering applications.https://cassyni-user-files-prod.s3.amazonaws.com/Hpnfd5wVEadD5bL6gccbze https://cassyni.com/events/Lb9VijR6iwCZAj1eBP7z7F/seminar/qa https://cassyni.com/slides/outline/Lb9VijR6iwCZAj1eBP7z7F https://cassyni.com/events/Lb9VijR6iwCZAj1eBP7z7F/abstract https://cassyni-user-files-prod.s3.amazonaws.com/SWPzu1KST3TxctbcoiiMUz https://cassyni.com/events/Lb9VijR6iwCZAj1eBP7z7F?videoPreview=1 Human Systems Integration – Human Space Exploration from the Digital Thread to Spacesuitsnohttps://cassyni.com/events/Lb9VijR6iwCZAj1eBP7z7F?videoPreview=12023-08-24T15:30:00+00:003535.76AIAA JournalExploration of Space with Humans requires a new depth of understanding of Human Systems Integration (HSI) for all stakeholders. This includes modelling human performance in reduced gravity environments and understanding effects of “Bioastronautics”. This talk provides a perspective on the importance of incorporating HSI into Extravehicular Activity (EVA) spacesuits. Spacesuits are human shaped spacecraft, which must not only protect against the extreme environments of space, but also enable mobility for a variety of different anthropometrically shaped humans. The application of HSI throughout the design and development of EVA spacesuits is critical for successful and safe human exploration of the Moon, Mars, and beyond.https://cassyni-user-files-prod.s3.amazonaws.com/SWPzu1KST3TxctbcoiiMUz https://cassyni.com/slides/outline/XTQnjmeeP1P2gzqfnvMg45 https://cassyni.com/events/XTQnjmeeP1P2gzqfnvMg45/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Uc8Ge9xBfZqjGnyyeUpGwY https://cassyni.com/events/XTQnjmeeP1P2gzqfnvMg45?videoPreview=1 Evolution of design approaches in asymmetric organocatalysis over the last decadenohttps://cassyni.com/events/XTQnjmeeP1P2gzqfnvMg45?videoPreview=12023-03-21T13:00:00+00:002343.68Tetrahedron Chem and Tetrahedron Green ChemThis seminar intends to cover the vast field of asymmetric organocatalysis and its evolution during the last ten years, evaluating the corresponding timeline of the progression of the field concerning the main synthetic approaches as well as the ground-breaking synergetic approach between experimental and computational methods. With the combination of an evolutionary trend and the expansion of computing technology, further advancements in the field of asymmetric organocatalysis are undeniable. In addition, a theoretical study on the computationally led design of catalysts within phase transfer catalysis and halogen bond-based catalysis will be presented. The delicate balance between steric and attractive Non-Covalent Interactions (NCIs), as the main controlling factors, in organocatalysis will be examined.https://cassyni-user-files-prod.s3.amazonaws.com/Uc8Ge9xBfZqjGnyyeUpGwY https://cassyni.com/events/2otcQ1fs8Y3UbNs61wk28m/seminar/qa https://cassyni.com/slides/outline/2otcQ1fs8Y3UbNs61wk28m https://cassyni.com/events/2otcQ1fs8Y3UbNs61wk28m/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Ei8bar4yKfEi94aiyQUP1Y https://cassyni.com/events/2otcQ1fs8Y3UbNs61wk28m?videoPreview=1 Ongoing over-exploitation and delayed responses to environmental change highlight the urgency for action to promote vertebrate recoveries by 2030nohttps://cassyni.com/events/2otcQ1fs8Y3UbNs61wk28m?videoPreview=12023-11-22T11:00:00+00:003371.76Royal Society PublishingTo safeguard nature, we must understand the drivers of biodiversity loss. Time-delayed biodiversity responses to environmental changes (ecological lags) are often absent from models of biodiversity change, despite their well-documented existence. We quantify how lagged responses to climate and land-use change have influenced mammal and bird populations around the world, while incorporating effects of direct exploitation and conservation interventions. Ecological lag duration varies between drivers, vertebrate classes and body size groupings—e.g. lags linked to climate-change impacts are 13 years for small birds, rising to 40 years for larger species. Past warming and land conversion generally combine to predict population declines; however, such conditions are associated with population increases for small mammals. Positive effects of management (>+4% annually for large mammals) and protected areas (>+6% annually for large birds) on population trends contrast with the negative impact of exploitation (<−7% annually for birds), highlighting the need to promote sustainable use. Model projections suggest a future with winners (e.g. large birds) and losers (e.g. medium-sized birds), with current/recent environmental change substantially influencing abundance trends to 2050. Without urgent action, including effective conservation interventions and promoting sustainable use, ambitious targets to stop declines by 2030 may already be slipping out of reach.https://cassyni-user-files-prod.s3.amazonaws.com/Ei8bar4yKfEi94aiyQUP1Y https://cassyni.com/slides/outline/6kzaRbJQS7h5XYYwGhmaNR https://cassyni.com/events/6kzaRbJQS7h5XYYwGhmaNR/abstract https://cassyni-user-files-prod.s3.amazonaws.com/M7pCpTiSf4YJAnsypvxysc https://cassyni.com/events/EAie7r1H1yzv285QEadJnR/seminar/qa https://cassyni.com/slides/outline/EAie7r1H1yzv285QEadJnR https://cassyni.com/events/EAie7r1H1yzv285QEadJnR/abstract https://cassyni-user-files-prod.s3.amazonaws.com/KoyC3exDgMmeHBjXMRpCnA https://cassyni.com/events/EAie7r1H1yzv285QEadJnR?videoPreview=1 Anthromes, CO2 and Terrestrial Carbon – Session 1: What are anthromes? Their geography and relevance to the carbon cyclenohttps://cassyni.com/events/EAie7r1H1yzv285QEadJnR?videoPreview=12023-03-28T13:00:00+00:007431.8The New Phytologist FoundationFull programme at https://anthromes-co2-and-terrestrial-carbon.evessiocloud.com/2023/en/page/full-programme 9.00 – 9.10: Welcome to the meeting 9.10 – 9.40: The history and evolution of anthromes, Erle Ellis* 9.40 – 10.10: Tropical forest anthromes and the past, present and future terrestrial carbon cycle, Yadvinder Malhi* 10.10 – 10.30: Change is in the air: The fate of grassy ecosystems in the Anthropocene , Nichola Stephens (presenting remotely) 10.30 – 10.50: Prospects for Satellite Remote Sensing to Identify Evolving Anthromes and Quantify Carbon Cycle Dynamics, Forrest Hoffman https://cassyni-user-files-prod.s3.amazonaws.com/KoyC3exDgMmeHBjXMRpCnA https://cassyni.com/slides/outline/BhUctRmephENyxqcmnpwnD https://cassyni.com/events/BhUctRmephENyxqcmnpwnD/abstract https://cassyni-user-files-prod.s3.amazonaws.com/MNcYLvXqZ8bePAxZh9ij2N https://cassyni.com/events/BhUctRmephENyxqcmnpwnD?videoPreview=1 Molecular Knots and Links in Channel and Slit Confinementnohttps://cassyni.com/events/BhUctRmephENyxqcmnpwnD?videoPreview=12022-02-24T09:00:00+00:003427.12Journal of Biological PhysicsSpatial confinement based on nanoslits and nanochannels has become a primary means for probing the properties of filamentous molecules, such as DNA. These setups also provide the ideal settings to study how the static and dynamics of biopolymers is affected by intra- and inter-molecular entanglement, as confinement can boost the emergence of knots and links. As it will be discussed in this talk, theoretical models and numerical simulations are invaluable for exposing the surprising reverberations of topological constraints on the physical behaviour of confined filaments. As prototypic examples, we will first discuss the evolution of geometrical and topological entanglement of individual molecules in a nano-dozer setup and then broaden considerations to pairs of catenated ring polymers in different types of confinement.https://cassyni-user-files-prod.s3.amazonaws.com/MNcYLvXqZ8bePAxZh9ij2N https://cassyni.com/events/Q3iMA9TfCVzy27mq2iL7Yy/seminar/qa https://cassyni.com/slides/outline/Q3iMA9TfCVzy27mq2iL7Yy https://cassyni.com/events/Q3iMA9TfCVzy27mq2iL7Yy/abstract https://cassyni-user-files-prod.s3.amazonaws.com/VChLJYrRvk8kbaGgJs7hEW https://cassyni.com/events/Q3iMA9TfCVzy27mq2iL7Yy?videoPreview=1 Molecular classification and grading of meningiomanohttps://cassyni.com/events/Q3iMA9TfCVzy27mq2iL7Yy?videoPreview=12023-04-17T20:00:00+00:001494.76Journal of Neuro-OncologyJoin Dr. Randy D'Amico and Dr. Jason Sheehan of the Journal of Neuro-Oncology for a discussion with Dr. MacLean Nasrallah from the University of Pennsylvania Perelman School of Medicine and Dr. Kenneth Aldape from The National Cancer Institute's Center for Cancer Research for a discussion about their latest publication on the molecular classification and grading of meningioma. https://cassyni-user-files-prod.s3.amazonaws.com/VChLJYrRvk8kbaGgJs7hEW https://cassyni.com/events/PZ9cTMMny8E17ePYRcgWr9/seminar/qa https://cassyni.com/slides/outline/PZ9cTMMny8E17ePYRcgWr9 https://cassyni.com/events/PZ9cTMMny8E17ePYRcgWr9/abstract https://cassyni-user-files-prod.s3.amazonaws.com/BrZL1DbQPetdVBAGNWdPU https://cassyni.com/events/PZ9cTMMny8E17ePYRcgWr9?videoPreview=1 Towards enhancing self-management nohttps://cassyni.com/events/PZ9cTMMny8E17ePYRcgWr9?videoPreview=12024-03-14T10:20:00+00:003191.04Imperial College Renal and Transplant CentreSchedule: 1] 10:20-10:40 Health Literacy in Kidney Care - Lina Johansson 2] 10:40-11:00 Are your patients taking their antihypertensive medication? If not, why not? New understandings to improve health equity and self-management - Shone Surendranhttps://cassyni-user-files-prod.s3.amazonaws.com/BrZL1DbQPetdVBAGNWdPU https://cassyni.com/slides/outline/RXk2e5wtixSmDMfmnaYTGh https://cassyni.com/events/RXk2e5wtixSmDMfmnaYTGh/abstract https://cassyni-user-files-prod.s3.amazonaws.com/XCLR7XrwYrhwvrBsc1LDMG https://cassyni.com/events/RXk2e5wtixSmDMfmnaYTGh?videoPreview=1 The plasmonic eigenvalue problem beyond the quasi-static limitnohttps://cassyni.com/events/RXk2e5wtixSmDMfmnaYTGh?videoPreview=12024-01-30T14:00:00+00:003744.08MetaMATPlasmonic resonances in nanoparticles can be understood in the quasi-static limit as solutions to the plasmonic eigenvalue problem, i.e. solutions to the quasi-static homogeneous Maxwell's equations when considering the permittivity as the eigenvalue; this formulation makes the modes material-independent. In this talk I will consider analogous versions of the plasmonic eigenvalue problem in two scenarios. First, the full wave regime in 2D where the subwavelength assumption on the size of the nanoparticle is abandoned and the wave scattering problem has to be modelled by the Helmholtz equation. Second (time permitting), the nonlocal hydrodynamic Drude model, which describes, qualitatively, the light-matter interactions at scales where the quantum nature of matter becomes apparent. I will present a rigorous spectral analysis of the plasmonic eigenvalue problem in these two scenarios. The main results are the completeness of the material-independent modes for the Helmholtz equation, and the regularizing properties of nonlocality in the nonlocal hydrodynamic Drude model.https://cassyni-user-files-prod.s3.amazonaws.com/XCLR7XrwYrhwvrBsc1LDMG https://cassyni.com/slides/outline/KyRNbFBDXJs3fuvroF9rM https://cassyni.com/events/KyRNbFBDXJs3fuvroF9rM/abstract https://cassyni-user-files-prod.s3.amazonaws.com/ABn8Ydde498kwPFZQ1Pvni https://cassyni.com/events/KyRNbFBDXJs3fuvroF9rM?videoPreview=1 Introduction to this second series of Biometals webinars, The biology of mammalian multi-copper ferroxidases, Arsenic antibiotics: old and newnohttps://cassyni.com/events/KyRNbFBDXJs3fuvroF9rM?videoPreview=12024-02-13T14:00:00+00:005129.0BioMetalsThe mammalian multi-copper ferroxidases comprise a family of conserved enzymes that are essential for body iron homeostasis. Their main function is to ensure the efficient release of iron from body cells, and they facilitate this process by oxidising ferrous iron to its ferric form, allowing iron to be effectively exported from tissues via the protein channel ferroportin. There are currently three mammalian multi-copper ferroxidases, ceruloplasmin, hephaestin and zyklopen, with each predicted to contain six biosynthetically incorporated copper atoms which act as intermediate electron acceptors. Ceruloplasmin is found predominantly in the circulation as a secreted protein and is particularly important in facilitating iron release from the liver. It also exists as a GPI-linked membrane-bound form in the central nervous system where it plays a role in brain iron homeostasis. In contrast, both hephaestin and zyklopen are attached to cellular membranes via a single C-terminal transmembrane domain. Hephaestin is predominantly expressed in the enterocytes of the gastrointestinal tract and is essential for the efficient absorption of dietary iron. While the function of zyklopen is less well understood, it appears to be important for normal hair development, although the precise role played is not known. There is also some evidence that these proteins may have other, non-iron-related physiological functions, however, these are poorly described. In this presentation, I will compare and contrast the biological roles of the mammalian multi-copper ferroxidases and present some of our latest data on this important group of enzymes. Bacteria compete for survival in microbial jungles. It's like Jeff Goldblum says in Jurassic Park: "Life, uh, finds a way,'" Most organisms just try to survive living in arsenic. But some have found ways to use organoarsenicals as weapons against other bacteria in the continual battle for dominance in microbial warfare, while others find ways to fight back. Life always finds a way! This presentation will briefly describe the plethora of ars proteins and their roles in biology and medicine. Arsenic has been a ubiquitous toxin since life first arose nearly 4 Bya in primordial anoxic oceans. In response to this environmental challenge, early organisms evolved genes/proteins for resistance pathways that transport and biotransform arsenic. Since we cloned the first arsenic operon in 1983, nearly every letter of the English alphabet has been utilized in the naming of ars genes. They encode a wide variety of enzymes, regulators and transport proteins. To date, nearly 30 genes with demonstrated functions have been identified in ars operons. Even more striking is the ability of microbes to utilize this toxic metalloid to gain a competitive advantage over other microbes. Early in evolution, bacteria evolved the arsM gene encoding the ArsM As(III) S-adenosylmethionine (SAM) methyltransferase, which catalyzes methylation of inorganic arsenic to form highly toxic methylarsenite (MAs(III)), which has antibiotic properties in extant microbial communities. MAs(III) producers used as an antibiotic to kill off competitors. In response, other members of microbial communities evolved a variety of genes/proteins for transforming methylarsenicals into less toxic forms, i.e., antibiotic resistance. After the Great Oxidation Event (GOE), there was an expansion of genes/proteins that could use oxygen for arsenic biotransformations, and a number of those evolved into MAs(III) resistances. A more recent example of the adaptation of arsenic as a weapon in microbial warfare is synthesis of the natural product arsinothricin (2-amino-4-(hydroxymethylarsinoyl)butanoic acid or AST) by the soil bacterium Burkholderia gladioli GSRB05. AST is a nonproteogenic amino acid that has broad-spectrum antibiotic action and is effective against both gram-positive and gram-negative bacteria, including some of the most dangerous human pathogens. Most recently we demonstrated that AST effectively inhibits both Plasmodium erythrocytic proliferation and parasite transmission to mosquitoes, We propose that AST is a promising lead compound for developing a new class of multi-stage antimalarials.https://cassyni-user-files-prod.s3.amazonaws.com/ABn8Ydde498kwPFZQ1Pvni https://cassyni.com/events/JcahedLtNTutdFXbRoLKZX/seminar/qa https://cassyni.com/events/JcahedLtNTutdFXbRoLKZX/abstract https://cassyni-user-files-prod.s3.amazonaws.com/7KELawMhfCJCNGVEdtibLr https://cassyni.com/events/JcahedLtNTutdFXbRoLKZX?videoPreview=1 Open Data & Springer Nature’s New Research Data Policynohttps://cassyni.com/events/JcahedLtNTutdFXbRoLKZX?videoPreview=12023-05-18T08:00:00+00:001610.36Topics at the heart of our communityResearch Data are a key component of our open science strategy. We want the data underlying our publications to be as open as possible to the research community. In order to build our data handling and services, we must ensure our policies are clearly understood, actionable and in line with community expectations. Springer Nature’s new research data policy strives to embed transparency while improving support for authors and editors.https://cassyni-user-files-prod.s3.amazonaws.com/7KELawMhfCJCNGVEdtibLr https://cassyni.com/slides/outline/K7EJhJzQovTwd24V2Ed7pq https://cassyni.com/events/K7EJhJzQovTwd24V2Ed7pq/abstract https://cassyni-user-files-prod.s3.amazonaws.com/RMvCj4efHEkzjpLvARhtBG https://cassyni.com/events/K7EJhJzQovTwd24V2Ed7pq?videoPreview=1 Flamelet generated manifold simulation of highly swirling spray combustion: Adoption of a mixed homogeneous reactor and inclusion of liquid-flame heat transfernohttps://cassyni.com/events/K7EJhJzQovTwd24V2Ed7pq?videoPreview=12023-06-30T09:00:00+00:001506.6Cassyni SeminarsWe undertake the modeling of the combustion of highly swirling fuel sprays using the Flamelet-Generated-Manifold (FGM) combustion-chemistry-reduction technique, especially the use of adiabatic tables generated with non-premixed chemical reactors. Preceding investigations indicated that tables thus generated can present uncertainties when used for predicting the finite-rate phenomena and different flame modes, and these are important for better prediction of spray flames in gas turbines. Thus, to address these, we have adopted a mixed-homogeneous chemical reactor that is applicable to both pre-mixed and non-premixed reactions and evaluated this using detailed computations of a constant-pressure mixed reactor. In addition, we have included curated levels of flame-liquid heat gain and loss in the generation of the FGM libraries and analyzed the effects on the major species formation. The methodologies were then incorporated into a Reynolds-averaged-Navier-Stokes model to analyze the data from the reacting ethanol spray flames, and the results were tested against the values of the mixture fraction at axial locations, the burner power output, the flame heat release structure, and the mean of the flame lift-off. The computed burner power output and mean flame lift-off were ∼90.4% and ∼89.6% of the reported experimental data, respectively. Compared with the newest published large-eddy-simulation data, the predictions for the mixture fraction values especially at the center of the flame in the central-recirculation-zone were not underestimated, and the spatial distribution of the flame OH captured the flame height and shape better. The inclusion of mixed homogeneous reactors and flame-liquid heat transfer in FGM can enhance their use in spray-combustion studies. https://cassyni-user-files-prod.s3.amazonaws.com/RMvCj4efHEkzjpLvARhtBG https://cassyni.com/events/VUqzffaS2Y6N9XMd3La1WM/seminar/qa https://cassyni.com/slides/outline/VUqzffaS2Y6N9XMd3La1WM https://cassyni.com/events/VUqzffaS2Y6N9XMd3La1WM/abstract https://cassyni-user-files-prod.s3.amazonaws.com/RcF1FQURVy33aJzURCJ9T4 https://cassyni.com/events/VUqzffaS2Y6N9XMd3La1WM?videoPreview=1 Large normal-stress differences observed in a novel self-assembling functionalized dipeptide surfactant solutionnohttps://cassyni.com/events/VUqzffaS2Y6N9XMd3La1WM?videoPreview=12023-06-21T14:00:00+00:001547.96Cassyni SeminarsA number of functionalised dipeptides self-assemble in water under specific conditions to give micellar aggregates. The micellar aggregates formed depend on the exact molecular structure and are important to understand as they control the properties both of the micellar phase and also of the gel phase which can be formed from these precursor solutions. We investigated the rheological properties of a functionalised dipeptide which behaves as a surfactant at high pH. This solution has been shown previously to exhibit very “stringy” behaviour, and this has previously been characterised using capillary breakup extensional rheometry (CaBER). In the current technical note, we extend the rheological characterisation of an exemplar precursor solution via small-amplitude oscillatory shear and steady shear. Using a cone-and-plate geometry and a dedicated protocol, we can measure the first normal-stress difference N1 and using a parallel-plate geometry to also measure (N1-N2), subsequently determining the second normal-stress difference N2. In so doing, we confirm that these systems are highly elastic, e.g. for shear rates greater than ~ 30 s−1, corresponding to a Weissenberg number based on the longest relaxation time ~ 330, N1 > 10τ where τ is the shear stress, and also, we find that N2 can be significant, is negative and approximately equal in magnitude to ~ 0.36 ± 0.05 N1. Significant uncertainties associated with the normal-stress difference data led to us using a range of different rheometers (and geometries) and highlight the issues with determining N2 using this two-measurement approach. Despite these uncertainties, the non-negligible value of the second-normal stress difference is demonstrated for these fluids. Image credit: [Niquirk (Unsplash)](https://unsplash.com/photos/a-purple-and-white-object-floating-in-the-air-Ja3hyjhnMns).https://cassyni-user-files-prod.s3.amazonaws.com/RcF1FQURVy33aJzURCJ9T4 https://cassyni.com/events/4HnBJoafeBrKK5mn1aoPH7/seminar/qa https://cassyni.com/slides/outline/4HnBJoafeBrKK5mn1aoPH7 https://cassyni.com/events/4HnBJoafeBrKK5mn1aoPH7/abstract https://cassyni-user-files-prod.s3.amazonaws.com/JugQwh1bK8VSqizM7xPyMQ https://cassyni.com/events/4HnBJoafeBrKK5mn1aoPH7?videoPreview=1 Session 6: Enabling technologiesnohttps://cassyni.com/events/4HnBJoafeBrKK5mn1aoPH7?videoPreview=12023-10-06T09:30:00+00:004604.64Brahmal Vasudevan Institute for Sustainable Aviation at Imperial College LondonIn this cross-disciplinary session we aim to make some links that otherwise may not be obvious during the workshop. **Chair: Andrea Castrichini (Airbus)**https://cassyni-user-files-prod.s3.amazonaws.com/JugQwh1bK8VSqizM7xPyMQ https://cassyni.com/events/9iuppKhSUDwiSVMa2D3HEV/abstract https://cassyni-user-files-prod.s3.amazonaws.com/XosCeQzHiYdc9tJ93abBmY https://cassyni.com/events/N59Z63PSr2iJUwsdEy9nER/seminar/qa https://cassyni.com/slides/outline/N59Z63PSr2iJUwsdEy9nER https://cassyni.com/events/N59Z63PSr2iJUwsdEy9nER/abstract https://cassyni-user-files-prod.s3.amazonaws.com/S93sUhqQFuhykmx19d4UML https://cassyni.com/events/N59Z63PSr2iJUwsdEy9nER?videoPreview=1 Ultra-High by-pass ratio engine Limits and Perspectivesnohttps://cassyni.com/events/N59Z63PSr2iJUwsdEy9nER?videoPreview=12023-12-12T13:00:00+00:003825.12Brahmal Vasudevan Institute for Sustainable AviationDue to the continuous increase of turbofan efficiencies driven by the increase of fan size (higher bypass ratio/lower fan pressure ratio), commercial aircraft fuel burn per seat has reduced drastically in the last 50 years. However, despite the specific fuel consumption of these type of engines is still dropping at a very healthy rate, a turning point on fuel burn is foreseen as consequence of the increase of weight and drag of the whole propulsion system. Aircraft and engine manufacturers have been working together for long time in order to get more efficiency of those engines compensating this negative impact with better aerodynamics and lighter materials. Since sustainable aviation will require this type of gas turbines for many years to come, and due to the expected high production cost of sustainable fuels, the efficiency of this type of gas turbines will be more important than ever. However, how much room for improvement is still available? The Limits and perspectives of ultra-high by-pass ratio engines will be discussed in this Seminar. https://cassyni-user-files-prod.s3.amazonaws.com/S93sUhqQFuhykmx19d4UML https://cassyni.com/slides/outline/QYPaKTd53KUnqtMBnf4QxM https://cassyni.com/events/QYPaKTd53KUnqtMBnf4QxM/abstract https://cassyni-user-files-prod.s3.amazonaws.com/nJdrhqZf9a2ZuhhrCoFcz https://cassyni.com/events/QYPaKTd53KUnqtMBnf4QxM?videoPreview=1 Mathematics in culture and clinic: from understanding cell behaviours to in silico clinical trialsnohttps://cassyni.com/events/QYPaKTd53KUnqtMBnf4QxM?videoPreview=12023-08-22T04:00:00+00:003198.16The Auckland Bioengineering InstituteThe use of mechanistic models can provide insight at every point in the understanding of disease and treatment, from traditional bench experiments through to emerging clinical applications, such as *in silico* clinical trials (ISTs). This talk will cover two distinct areas of research that sit at opposite ends of this spectrum. Firstly, in the clinical application domain, previous work I did as part of the INSIST project, where we developed a framework to run ISTs for the treatment of acute ischemic stroke. ISTs test treatment therapies on large cohorts of virtual patients to supplement traditional clinical trials and reduce the risk, cost, and time required for testing new therapies. The framework includes both statistical and mechanistic models to generate virtual patients, model the stroke pathophysiology and treatment, and predict the outcome for each patient. I will give an overview of the INSIST framework and present several exploratory trials we ran. The second topic will be current work using mechanistic agent-based modelling to better understand cell behaviour in culture. This is motivated by a project combining *in vitro* experiments and mechanistic modelling to unravel mechanisms behind endometriosis onset. Effective use of cell culture experiments to inform models, and models to inform experiments, can be very powerful but is often not straightforward in practice. I will discuss my work on this to date, and also use this opportunity to provide a brief introduction to agent-based modelling for those who are interested in learning about this modelling approach. https://cassyni-user-files-prod.s3.amazonaws.com/nJdrhqZf9a2ZuhhrCoFcz https://cassyni.com/slides/outline/KbuXrd9pejwmSndqnBMRED https://cassyni.com/events/KbuXrd9pejwmSndqnBMRED/abstract https://cassyni-user-files-prod.s3.amazonaws.com/2Zex3GwmcaeiVJK5JyJ8Sr https://cassyni.com/events/KbuXrd9pejwmSndqnBMRED?videoPreview=1 Protocols for the Mpemba effect in granular fluidsnohttps://cassyni.com/events/KbuXrd9pejwmSndqnBMRED?videoPreview=12022-12-20T12:00:00+00:004221.72Granular MatterThe so-called Mpemba effect (ME) is a counterintuitive memory phenomenon according to which, given two samples of a fluid, the initially hotter one may cool more rapidly than the initially cooler one to a common steady state. Although initially reported in the case of water, its existence for that liquid is still questioned. On the other hand, the ME has been observed to emerge (both theoretically and computationally) in the case of granular fluids, where the role of temperature (T) is played by the mean kinetic energy per particle and the steady state is tuned by a certain set of control parameters. The key point responsible for the ME in granular fluids is the observation that the relaxation of T(t) to its stationary value is governed not only by its initial value T(0) but also by the initial values of one or more additional variables. In some of the works in the literature on the ME for granular fluids, the state at t=0 was assumed ad hoc, without a description of the prior preparation protocols for t<0. In this talk, I will discuss two classes of granular systems where protocols for the ME can be clearly devised. In the first class, the system is an inertial suspension made of inelastic and smooth hard spheres under shear [1], the control parameters being the shear rate and the bath temperature. One of the samples (A) is prepared in a quasi-equilibrium unsheared steady state, while the other sample (B) is prepared in a sheared steady state with a bath temperature smaller than that of sample A. Then, at t=0, a common bath temperature (equal to that of sample B) and a common shear rate (smaller than that of sample B) are applied and both systems are allowed to relax to the new steady state. The second class of systems is defined by a dilute two-dimensional gas of hard and rough hard disks driven by a stochastic force and a stochastic torque, which inject translational and rotational energy, respectively [2]. In this case, the control parameters are the noise temperature associated with the total noise intensity and the fraction of rotational noise. In the preparation protocol for the standard ME, sample A is prepared with a higher noise temperature than sample B, the fraction of rotational noise being 0 and 1 for samples A and B, respectively. At t=0, both samples are subjected to a common noise temperature (smaller than that of sample B) and a common fraction of rotational noise (different from 0 and 1), and their relaxation to the new steady state is analyzed.https://cassyni-user-files-prod.s3.amazonaws.com/2Zex3GwmcaeiVJK5JyJ8Sr https://cassyni.com/slides/outline/5mkcZV38MvSHocB8sW11VP https://cassyni.com/events/5mkcZV38MvSHocB8sW11VP/abstract https://cassyni-user-files-prod.s3.amazonaws.com/AYBjaT7aTMyDmt4WRpHgNr https://cassyni.com/events/5mkcZV38MvSHocB8sW11VP?videoPreview=1 Microstructure imaging by diffusion MRI: modeling, simulation, machine learning, application to brain imaging and morenohttps://cassyni.com/events/5mkcZV38MvSHocB8sW11VP?videoPreview=12022-02-03T12:30:00+00:003141.6Journal on Image and Video ProcessingMagnetic resonance (MR) imaging is the reference imaging modality both for functional and structural study of the human brain. Diffusion MR imaging allows measuring the water diffusion properties in every voxel of a volume. When considering the white matter of the brain, this low-level information allows to infer higher-level information, namely about the orientation of the neuronal fiber bundles, and therefore about brain connectivity as a whole. In this talk, we will first give a brief introduction to the physical phenomenon of diffusion and how it can be used in MRI to infer brain neuronal fiber orientation information. Then we will show that it actually can provide much more information than just fiber orientation. Indeed, by developing realistic tissue microstructure models, advanced diffusion MR sequences and robust model estimation techniques, we will show how to estimate tissue parameters at the microscopic scale from the macroscopic MR signals. In particular, we will introduce some of our recent works in this domain, where hyper-realistic synthetic tissue models, advanced Monte-Carlo simulations and ML-based estimation techniques are developed and combined. We will show the application of those techniques to address the analysis of the brain microstructure and discuss their potential in the analysis of other tissues.https://cassyni-user-files-prod.s3.amazonaws.com/AYBjaT7aTMyDmt4WRpHgNr https://cassyni.com/slides/outline/FeihV9yd95Wcf8BAP4mNdK https://cassyni.com/events/FeihV9yd95Wcf8BAP4mNdK/abstract https://cassyni-user-files-prod.s3.amazonaws.com/2pwA3xxRS7mUGhL1Mozonn https://cassyni.com/events/FeihV9yd95Wcf8BAP4mNdK?videoPreview=1 Robust Explainable AI: the Case of Counterfactual Explanationsnohttps://cassyni.com/events/FeihV9yd95Wcf8BAP4mNdK?videoPreview=12023-10-24T12:00:00+00:003339.04Imperial College London Early Career Researcher InstituteCounterfactual explanations (CXs) are routinely used to shed light on the decisions of machine learning models; however, CX generation strategies often lack robustness, which may jeopardise their explanatory function. In this talk we will begin by introducing the problem of (lack of) robustness and discuss its implications. We will then present some recent solutions we developed to compute CXs with formal robustness guarantees using tools from discrete optimisation and formal verification.https://cassyni-user-files-prod.s3.amazonaws.com/2pwA3xxRS7mUGhL1Mozonn https://cassyni.com/slides/outline/NZpnFMYrgrC8JQs935GkQd https://cassyni.com/events/NZpnFMYrgrC8JQs935GkQd/abstract https://cassyni-user-files-prod.s3.amazonaws.com/JUeA7WicR7RAGPeJvDYjw4 https://cassyni.com/events/NZpnFMYrgrC8JQs935GkQd?videoPreview=1 Effect of electrogenerated random defects on Pt(111) surface over methanol electrooxidation: Electrochemical and spectroscopic studiesnohttps://cassyni.com/events/NZpnFMYrgrC8JQs935GkQd?videoPreview=12024-02-25T12:00:00+00:002532.8Electrochimica ActaIn the present paper, the influence of electrogenerated (110) defects in the methanol oxidation reaction (MOR) on a Pt(111) electrode has been studied. It is shown that methanol oxidation is favored at the defected surfaces as evidenced by the displacement of the onset potential to lower values and the increase of the peak current density. The currents obtained by transient curves at short times (0.015 – 0.50 s) at 0.50 V vs RHE demonstrate the faster formation of strongly adsorbed species on disordered surfaces when compared to Pt(111). On the other hand, for long-term transient currents (600 s), the surface with a higher surface density of (110) defects presented the best activity among all ones studied. Galvanostatic results showed that potential oscillations emerged only on disordered surfaces. The large induction time up to the beginning of the oscillations as well as the lower fre­ quency registered on these surfaces demonstrates the enhancement of CO formation on defects. This point is confirmed by in situ FTIR experiments. From the results obtained by using electrochemical techniques, it was possible to infer that the dehydration rate constant (kdh) and the rate constant for CO oxidation (kCO) are affected by the number of (110) defects, which give rise to kCO and kdh values higher than those obtained for Pt(111).https://cassyni-user-files-prod.s3.amazonaws.com/JUeA7WicR7RAGPeJvDYjw4 https://cassyni.com/slides/outline/HdLjnX5cJGf6uK9o2bZkgV https://cassyni.com/events/HdLjnX5cJGf6uK9o2bZkgV/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Dt759ZeGCnMfBS1sVCztg6 https://cassyni.com/events/HdLjnX5cJGf6uK9o2bZkgV?videoPreview=1 Introducing Transformative Plant Biotechnology: Recoding Gene Regulatory Networksnohttps://cassyni.com/events/HdLjnX5cJGf6uK9o2bZkgV?videoPreview=12023-09-21T08:00:00+00:001870.56The New Phytologist FoundationQuantitative traits are determined by many genes and impacted by the environment. These traits result from the actions of suites of genes working combinatorially within complex gene regulatory networks (GRNs) that often contain partially redundant nodes and numerous network motifs, such as feedforward and feedback loops, that define and finetune network dynamics. Genetic technologies can be used to enhance crops and promote sustainable agriculture. However, the manipulation of traits governed by networks with complex topologies can be challenging. Predicting the effects of perturbations has been a significant barrier to applying genetic engineering to the improvement of quantitative traits. The process of rewiring or reconstructing regulatory networks using synthetic biology approaches can aid the understanding of how phenotypes emerge from network functions and inform rational engineering. Nitrogen is a critical nutrient for plant growth and yield. While external N has facilitated modern agriculture, over-application of N-containing fertilizers has drastic ecological and environmental consequences. In a recent project, we focus on elucidating a regulatory circuit acting upstream of the critical NIN-LIKE PROTEIN7 transcription factor and its conservation and divergence in plant lineages. The resulting network models provide a framework for targeted engineering to increase plant nitrogen use efficiency. We have deployed a range of engineering techniques to perturb the network, observing changes in plant growth in response to nitrate.https://cassyni-user-files-prod.s3.amazonaws.com/Dt759ZeGCnMfBS1sVCztg6 https://cassyni.com/events/VyYqwcFjGiVxnzPbzx8Upd/abstract https://cassyni-user-files-prod.s3.amazonaws.com/546kZ64JmrkAN5HHHxTupi https://cassyni.com/slides/outline/R34oUmnUt8xwPtgFzURV6V https://cassyni.com/events/R34oUmnUt8xwPtgFzURV6V/abstract https://cassyni-user-files-prod.s3.amazonaws.com/NTHMh5FHab2DVG9GEJhG6r https://cassyni.com/events/R34oUmnUt8xwPtgFzURV6V?videoPreview=1 Mechanistic models and machine learning: friends or foes?nohttps://cassyni.com/events/R34oUmnUt8xwPtgFzURV6V?videoPreview=12021-11-17T12:00:00+00:002767.76Discover Applied SciencesDeep learning, as many other disciplines in artificial intelligence, makes use of great quantities of data to identify the important features to learn of an event or behavior. Nevertheless, when we introduce some knowledge, such as the principles of the thermodynamics, we optimize the process of learning and, what is more, we are capable of developing interpretable models. The present work proposes the implementation of the so-called Structure Preserving Neural Network (SPNN) [1] to build a model to emulate sloshing dynamics. The cited neural network learns the GENERIC structure [2] of the dynamics by means of data. Its constraints ensure the fulfillment of energy conservation and entropy generation to provide accurate, interpretable, and trustable results. Following the spirit of deep learning, and given the high dimensionality of the problem, the dataset has been projected to a lower dimensional manifold with a sparse-autoencoder. There, we perform the learning process optimally over the main features of the dynamics embedded in the latent space. The net has been tested with a proof-of-concept fluid, which will be the basis to learn new behaviors. In addition, we address the inclusion of data acquisition for learning corrections, as well as new behaviors, from limited real-world data. When working with synthetic data for data-driven learning, i.e. data obtained from computer simulations, we can work with state variables that are not easily measurable, or even internal variables. We propose an approach based on Recurrent Neural Networks to relate measurements of the free surface of a liquid from video frames with the embedded space previously found to learn, predict and correct new behaviors.https://cassyni-user-files-prod.s3.amazonaws.com/NTHMh5FHab2DVG9GEJhG6r https://cassyni.com/slides/outline/TWJpiC275RjRkq9pYAL7pR https://cassyni.com/events/TWJpiC275RjRkq9pYAL7pR/abstract https://cassyni-user-files-prod.s3.amazonaws.com/H968XgvJe2fJezigdTNfxi https://cassyni.com/events/TWJpiC275RjRkq9pYAL7pR?videoPreview=1 Membrane functionalization in artificial cell engineeringnohttps://cassyni.com/events/TWJpiC275RjRkq9pYAL7pR?videoPreview=12021-04-06T12:00:00+00:002516.08Discover Applied SciencesBottom-up synthetic biology aims to construct mimics of cellular structure and behaviour known as artificial cells from a small number of molecular components. The development of this nascent field has coupled new insights in molecular biology with large translational potential for application in fields such as drug delivery and biosensing. Multiple approaches have been applied to create cell mimics, with many efforts focusing on phospholipid-based systems. This mini-review focuses on different approaches to incorporating molecular motifs as tools for lipid membrane functionalization in artificial cell construction. Such motifs range from synthetic chemical functional groups to components from extant biology that can be arranged in a ‘plug-and-play’ approach which is hard to replicate in living systems. Rationally designed artificial cells possess the promise of complex biomimetic behaviour from minimal, highly engineered chemical networks.https://cassyni-user-files-prod.s3.amazonaws.com/H968XgvJe2fJezigdTNfxi https://cassyni.com/slides/outline/ADcg6GNjiQMK5xPYypbkYm https://cassyni.com/events/ADcg6GNjiQMK5xPYypbkYm/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Wg6J5fxgZwNQNR2WCLWbsk https://cassyni.com/events/ADcg6GNjiQMK5xPYypbkYm?videoPreview=1 Effects of porous medium filling on thermally developing forced convection in a parallel plate channelnohttps://cassyni.com/events/ADcg6GNjiQMK5xPYypbkYm?videoPreview=12023-12-19T08:00:00+00:001973.0International Journal of ThermofluidsThis study obtains the semi-analytical solutions and explores the thermal characteristics of a thermally developing flow in a parallel plate channel, partially filled with a porous medium at the core, while considering local thermal non-equilibrium conditions, and viscous dissipation for the first time. The developing temperature field, for a porous medium filling of volume fraction fixed at 0.9, indicates an increasing difference in temperature between the solid and fluid phases with the axial distance. Besides, heat flux bifurcation starts in the entrance region as more heat diffuses to the solid at the interface, more markedly with a decreasing Darcy number, Da. When the thermal transport is dominated by interstitial heat transfer between solid and fluid in the porous medium, the thermal entrant length is the shortest. An increasing amount of porous medium filling with such quality and an increasing Da tend to shorten the thermal entry length. Nonetheless, as a lower Da porous media convects more heat away from the interface, it expedites the thermal development in cases where interstitial heat transfer in porous medium is poor. With an increasing porous medium fraction, the impact of viscous dissipation on heat transfer magnifies at the entrance region, thereby reducing the effectiveness of porous medium insert.https://cassyni-user-files-prod.s3.amazonaws.com/Wg6J5fxgZwNQNR2WCLWbsk https://cassyni.com/slides/outline/CgrhKgcMuh7oSts7XWWPGh https://cassyni.com/events/CgrhKgcMuh7oSts7XWWPGh/abstract https://cassyni-user-files-prod.s3.amazonaws.com/HmRyNpzMVBSzQ1QjWp8afx https://cassyni.com/events/CgrhKgcMuh7oSts7XWWPGh?videoPreview=1 Simulating the interaction between tidal flows and convectionnohttps://cassyni.com/events/CgrhKgcMuh7oSts7XWWPGh?videoPreview=12021-04-21T14:35:00+00:00883.6Leeds Institute for Fluid DynamicsTidal interactions are important in driving spin and orbital evolution in various astrophysical systems such as hot Jupiters, close bi-nary stars, and planetary satellites. However, the fluid dynamical mechanisms responsible for tidal dissipation in giant planets and stars remain poorly understood. One key mechanism is the interaction between tidal flows and turbulent convection which is thought to act as an eddy viscosity dampening the large scale tidal flow. Using hydrodynamical simulations we investigate the dissipation of the large scale equilibrium tide as a result of its interaction with convection. Our approach is to conduct an extensive parameter sur-vey in order to study the interaction be-tween an oscillatory background shear flow, which represents a large-scale tidal flow, and the convecting fluid inside a small patch of a star or planet. This study has required data from a large number of simulations, where many have long integration times, and hence could not be possible without the use of HPC.https://cassyni-user-files-prod.s3.amazonaws.com/HmRyNpzMVBSzQ1QjWp8afx https://cassyni.com/slides/outline/G9RYm6evPFvDJHdJNqiWiR https://cassyni.com/events/G9RYm6evPFvDJHdJNqiWiR/abstract https://cassyni-user-files-prod.s3.amazonaws.com/FCnCdXiVm7nm8q7cZqmBGr https://cassyni.com/events/G9RYm6evPFvDJHdJNqiWiR?videoPreview=1 Dynamic evolution of locomotor performance independent of changes in extended phenotype use in spidersnohttps://cassyni.com/events/G9RYm6evPFvDJHdJNqiWiR?videoPreview=12024-02-19T10:00:00+00:002865.04Royal Society PublishingMany animals use self-built structures (extended phenotypes) to enhance body functions, such as thermoregulation, prey capture or defence. Yet, it is unclear whether the evolution of animal constructions supplements or substitutes body functions—with disparate feedbacks on trait evolution. Here, using brown spiders (Araneae: marronoid clade), we explored if the evolutionary loss and gain of silken webs as extended prey capture devices correlates with alterations in traits known to play an important role in predatory strikes—locomotor performance (sprint speed) and leg spination (expression of capture spines on front legs). We found that in this group high locomotor performance, with running speeds of over 100 body lengths per second, evolved repeatedly—both in web-building and cursorial spiders. There was no correlation with running speed, and leg spination only poorly correlated, relative to the use of extended phenotypes, indicating that web use does not reduce selective pressures on body functions involved in prey capture and defence per se. Consequently, extended prey capture devices serve as supplements rather than substitutions to body traits and may only be beneficial in conjunction with certain life-history traits, possibly explaining the rare evolution and repeated loss of trapping strategies in predatory animals.https://cassyni-user-files-prod.s3.amazonaws.com/FCnCdXiVm7nm8q7cZqmBGr https://cassyni.com/slides/outline/M5ubDw8AmqTWkhuysvmt8D https://cassyni.com/events/M5ubDw8AmqTWkhuysvmt8D/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Kk2PZZaTF1fP5xbBYxrgrJ https://cassyni.com/events/M5ubDw8AmqTWkhuysvmt8D?videoPreview=1 Interaction between fast tides and convection with application to giant planets and solar type starsnohttps://cassyni.com/events/M5ubDw8AmqTWkhuysvmt8D?videoPreview=12021-12-03T12:00:00+00:003227.0Leeds Institute for Fluid DynamicsWe propose a new formalism to calculate the exchange of energy between tides and a convective flow when the turnover timescale is larger than the tidal period. We argue that the standard picture, in which the tides are described as a mean shear flow which is damped by fluctuating convective eddies, is inconsistent and should be reversed. In other words, the fluctuations are the tidal oscillations and the mean shear flow is provided by the largest convective eddies. We further argue that, even if energy is intermittently transferred from convection to the tides, it must ultimately return to the convective flow and transported efficiently to the stellar surface on the convective timescale. This is consistent with assuming that energy is locally transferred from the tides to the convective flow. Using this assumption, we obtain values for the tidal dissipation Q factor of Jupiter and Saturn, for the circularization periods of late-type binaries (taking into account the full time evolution of the stellar structure) and for hot Jupiters in good overall agreement with observations.https://cassyni-user-files-prod.s3.amazonaws.com/Kk2PZZaTF1fP5xbBYxrgrJ https://cassyni.com/slides/outline/L6cP8Zq7tvMN5x5ymxJZKK https://cassyni.com/events/L6cP8Zq7tvMN5x5ymxJZKK/abstract https://cassyni-user-files-prod.s3.amazonaws.com/9zZ94gQeXht3ZvqyeFvHTt https://cassyni.com/events/L6cP8Zq7tvMN5x5ymxJZKK?videoPreview=1 Parallel-in-time multiple shooting for optimal control problems governed by the Navier–Stokes equationsnohttps://cassyni.com/events/L6cP8Zq7tvMN5x5ymxJZKK?videoPreview=12024-01-17T12:00:00+00:001858.64Computer Physics CommunicationsIn the past decades, multiple shooting methods have proven to be a promising direction to speed up the optimization process, especially in the context of ODE-based optimization. Very recently, Fang et al. (Journal of Computational Physics, vol. 452, 110926, 2022) proposed a multiple shooting algorithm for large-scale PDE-constrained optimization. The current paper continues this line of work and explores the potential of multiple shooting methods for optimal control problems governed by the three-dimensional Navier–Stokes equations. Similar to Fang et al., the augmented Lagrangian (AL) method is used to solve the resulting equality-constrained optimization problem, and we employ the classical limited-memory BFGS method for the unconstrained subproblems inside the AL loop. In the current work, we exploit the multiple shooting paradigm in full by processing the shooting windows parallel-in-time, allowing for significant parallel speed-ups compared to single shooting. The proposed method is validated on a velocity tracking case, using up to 100 windows. Our analysis shows that the multiple shooting algorithm allows for considerable algorithmic and parallel speed-ups. While algorithmic speed-up depends on the exact tracking case and initialization of the shooting windows, the multiple shooting algorithm always outperforms single shooting in terms of computational time (if the number of windows is sufficiently high) due to the parallel-in-time implementation. For a given amount of resources, we also show that the proposed parallel-in-time strategy can outperform spatial parallelization alone, especially when the spatial parallelization is saturated.https://cassyni-user-files-prod.s3.amazonaws.com/9zZ94gQeXht3ZvqyeFvHTt https://cassyni.com/slides/outline/6GTTqRiRc6qtSmdGsGx9aV https://cassyni.com/events/6GTTqRiRc6qtSmdGsGx9aV/abstract https://cassyni-user-files-prod.s3.amazonaws.com/7WsJ6HnY75CANLB3HGYCNA https://cassyni.com/events/6GTTqRiRc6qtSmdGsGx9aV?videoPreview=1 Are beliefs about the importance of genetics for cancer prevention and early detection associated with high risk cancer genetic testing in the U.S. Population?nohttps://cassyni.com/events/6GTTqRiRc6qtSmdGsGx9aV?videoPreview=12023-07-20T14:00:00+00:002817.88Center for Cancer TrainingPublic attitudes towards germline genetic testing for inherited cancers have been found to be generally positive. We know that diverse causal beliefs about cancer and sociodemographic factors are associated with uptake of cancer genetic testing. However, it is unclear how beliefs about genetically informed cancer prevention and genetically informed early detection of cancer shape testing behaviors. Using data from the National Health Information National Trends Survey, we studied this relationship between belief about cancer genetics and participation in cancer genetic testing. Interestingly, we find that belief in the importance of genetics for early detection of cancer was associated with testing however, belief in the importance of genetics for cancer prevention was not. The pattern of association is a surprising finding that warrants further investigation as better understanding cancer prevention beliefs and their impact on genetic test uptake may inform population genetic testing efforts.https://cassyni-user-files-prod.s3.amazonaws.com/7WsJ6HnY75CANLB3HGYCNA https://cassyni.com/slides/outline/3oDSc1UoQp5MQcPVQV9naH https://cassyni.com/events/3oDSc1UoQp5MQcPVQV9naH/abstract https://cassyni-user-files-prod.s3.amazonaws.com/2nAHsLiXwoi3c4DddQmEJa https://cassyni.com/events/3oDSc1UoQp5MQcPVQV9naH?videoPreview=1 The Landau Hamiltonian with delta-potentials supported on curvesnohttps://cassyni.com/events/3oDSc1UoQp5MQcPVQV9naH?videoPreview=12023-10-05T15:00:00+00:002840.44Journal of Mathematical SciencesThe spectral properties of a singularly perturbed self-adjoint Landau Hamiltonian in the plane with a delta-potential supported on a finite curve are studied. After a general discussion of the qualitative spectral properties of the perturbed Landau Hamiltonian and its resolvent, one of our main objectives is a local spectral analysis near the Landau levels. This talk is based on joint works with P. Exner, M. Holzmann, V. Lotoreichik, and G. Raikov.https://cassyni-user-files-prod.s3.amazonaws.com/2nAHsLiXwoi3c4DddQmEJa https://cassyni.com/slides/outline/AiHuFaY9ZDq8uRP4mviiiy https://cassyni.com/events/AiHuFaY9ZDq8uRP4mviiiy/abstract https://cassyni-user-files-prod.s3.amazonaws.com/8WAWBf5ayzJQPXXVDSnyjc https://cassyni.com/events/AiHuFaY9ZDq8uRP4mviiiy?videoPreview=1 The Ratio of Key Metabolic Transcripts Is a Predictive Biomarker of Breast Cancer Metastasis to the Lungnohttps://cassyni.com/events/AiHuFaY9ZDq8uRP4mviiiy?videoPreview=12024-03-21T18:00:00+00:003174.8Center for Cancer TrainingBreast cancer is a disease marked by cellular diversity. Primary breast tumors can spread to and colonize multiple organ sites, forming metastases. Understanding the factors that drive metastatic tropism and being able to predict metastasis to specific organs a priori remains a challenge. In this study, we investigated how rewired metabolism underlying organ-specific metastasis in breast cancer could help identify strategies to improve the treatment and prevention of metastatic disease. We found that parental breast cancer cells and metastases in the brain and lung each had a distinct, heritable metabolic flux signature. Lung metastatic cells maintained particularly high glycolytic flux by activating a pathway sink into lactate, characterized by a high ratio of lactate dehydrogenase (LDH) to pyruvate dehydrogenase (PDH) gene expression. This elevated LDH/PDH ratio also correlated with lung metastasis in patients with breast cancer. We employed feature classification models on patient data and found that expression of genes taken individually or collectively were unable to predict metastatic tropism. However, the LDH/PDH ratio was a significant predictor of metastasis to the lung specifically. Importantly, alterations of LDH/PDH in the primary tumor in cell lines and patients indicated future lung metastases, such that this ratio was a bona fide predictor. Lung metastases in pancreatic cancer models also exhibited the same metabolic flux alteration, suggesting that lactate production may be a convergent phenotype in lung metastasis across cancer types. Together, these analyses highlight the essential role that metabolism plays in organ-specific cancer metastasis and identify a putative biomarker for predicting lung metastasis in breast cancer patients.https://cassyni-user-files-prod.s3.amazonaws.com/8WAWBf5ayzJQPXXVDSnyjc https://cassyni.com/events/BCwWJGBfzgPBuBuxNN1WzH/seminar/qa https://cassyni.com/slides/outline/BCwWJGBfzgPBuBuxNN1WzH https://cassyni.com/events/BCwWJGBfzgPBuBuxNN1WzH/abstract https://cassyni-user-files-prod.s3.amazonaws.com/GXUQcNKTA3WbzLY6n9UaiS https://cassyni.com/events/BCwWJGBfzgPBuBuxNN1WzH?videoPreview=1 Reconstructing complex flows using neural data assimilationnohttps://cassyni.com/events/BCwWJGBfzgPBuBuxNN1WzH?videoPreview=12024-04-09T14:00:00+00:003655.04Experiments in FluidsWe report a neural data assimilation (DA) algorithm that can reconstruct turbulent Eulerian flow states in a large spatio-temporal domain from noisy Lagrangian tracks. The tracks are obtained via particle tracking velocimetry (PTV): an essential tool for experimental research on fluid turbulence. In PTV, tracer particles are seeded into a flow, illuminated, imaged, and linked across frames to produce a set of spatially-sparse Lagrangian particle trajectories, a.k.a. “tracks.” DA is frequently used to combine the tracks with equations that govern the flow to accurately reconstruct the velocity field and infer latent fields like pressure or density. Crucially, localization and tracking errors can degrade the performance of PTV, especially when using a single-camera setup as in plenoptic or digital-inline-holography PTV. Moreover, the particles may too heavy, too light, too large, or too abundant to act as ideal tracers, preventing easy access to the flow. Our neural DA algorithm can compensate for large, anisotropic localization errors, tracking errors, and inertial particle transport. We formulate physics losses based on the Navier–Stokes and Maxey–Riley equations. PTV data is embedded in our particle transport model as a hard constraint, and the tracked positions, size, and density of each particle may be estimated as part of the reconstruction. We demonstrate the method using simulated measurements of turbulent flows. Accurate flow states and particle properties are reconstructed from unlabeled PTV data.https://cassyni-user-files-prod.s3.amazonaws.com/GXUQcNKTA3WbzLY6n9UaiS https://cassyni.com/slides/outline/J83b4TkuYT4hYUbw2NWtmb https://cassyni.com/events/J83b4TkuYT4hYUbw2NWtmb/abstract https://cassyni-user-files-prod.s3.amazonaws.com/PTVVtuda5RbwXxNRwjTSAa https://cassyni.com/events/J83b4TkuYT4hYUbw2NWtmb?videoPreview=1 Advances in Skeletal Editing and Rearrangement Reactionsnohttps://cassyni.com/events/J83b4TkuYT4hYUbw2NWtmb?videoPreview=12023-11-15T14:00:00+00:006215.96Thieme GroupSkeletal editing allows chemists to insert, delete or exchange atoms in molecules. The focus of this webcheminar was on transformations that modify the heavy-atom skeleton of organic compounds, especially those amenable to late-stage synthesis. Transformations agnostic of the underlying chemical modality (e.g., transition metal catalysis, photochemistry, reagent development, etc.).https://cassyni-user-files-prod.s3.amazonaws.com/PTVVtuda5RbwXxNRwjTSAa https://cassyni.com/events/LbHcHszXjjqBuR5Va4RXVX/abstract https://cassyni-user-files-prod.s3.amazonaws.com/3PQrFvh25tNM17upWCdxte https://cassyni.com/slides/outline/UzJt5VzTCXFB4kRxdukaiR https://cassyni.com/events/UzJt5VzTCXFB4kRxdukaiR/abstract https://cassyni-user-files-prod.s3.amazonaws.com/9QAMLVs5bzHcVDu3amszNi https://cassyni.com/events/UzJt5VzTCXFB4kRxdukaiR?videoPreview=1 Crocodile perception of distress in hominid baby criesnohttps://cassyni.com/events/UzJt5VzTCXFB4kRxdukaiR?videoPreview=12024-02-14T10:00:00+00:002949.32Royal Society PublishingIt is generally argued that distress vocalizations, a common modality for alerting conspecifics across a wide range of terrestrial vertebrates, share acoustic features that allow heterospecific communication. Yet studies suggest that the acoustic traits used to decode distress may vary between species, leading to decoding errors. Here we found through playback experiments that Nile crocodiles are attracted to infant hominid cries (bonobo, chimpanzee and human), and that the intensity of crocodile response depends critically on a set of specific acoustic features (mainly deterministic chaos, harmonicity and spectral prominences). Our results suggest that crocodiles are sensitive to the degree of distress encoded in the vocalizations of phylogenetically very distant vertebrates. A comparison of these results with those obtained with human subjects confronted with the same stimuli further indicates that crocodiles and humans use different acoustic criteria to assess the distress encoded in infant cries. Interestingly, the acoustic features driving crocodile reaction are likely to be more reliable markers of distress than those used by humans. These results highlight that the acoustic features encoding information in vertebrate sound signals are not necessarily identical across species.https://cassyni-user-files-prod.s3.amazonaws.com/9QAMLVs5bzHcVDu3amszNi https://cassyni.com/slides/outline/XTYuJvE5Pp1fRguXBbfDSM https://cassyni.com/events/XTYuJvE5Pp1fRguXBbfDSM/abstract https://cassyni-user-files-prod.s3.amazonaws.com/6PbeA95WjH5Rq61YRFfkgn https://cassyni.com/events/XTYuJvE5Pp1fRguXBbfDSM?videoPreview=1 Should We Embrace Impossible Worlds Due to the Flaws of Normal Modal Logic?nohttps://cassyni.com/events/XTYuJvE5Pp1fRguXBbfDSM?videoPreview=12024-02-14T15:00:00+00:004376.08Logica UniversalisSome philosophers advance the claim that the phenomena of logical omniscience and of the indiscernibility of metaphysical statements, which arise in (certain) interpretations of normal modal logic, provide strong reasons in favour of impossible world approaches. These two specific lines of argument will be presented and discussed in this paper. Contrary to the recent much-held view that the characteristics of these two phenomena provide us with strong reasons to adopt impossible world approaches, the view defended here is that no such ‘knock-down arguments’ do emanate on those grounds. This is not to rule out that there cannot be any other good reasons for assuming impossible world semantics. However, the discussion of a further argument for impossible worlds will suggest that different attempts to argue for them likely present intertwined problems.https://cassyni-user-files-prod.s3.amazonaws.com/6PbeA95WjH5Rq61YRFfkgn https://cassyni.com/slides/outline/U11fz8hQKc92PzbxXwHFuX https://cassyni.com/events/U11fz8hQKc92PzbxXwHFuX/abstract https://cassyni-user-files-prod.s3.amazonaws.com/pbhEL6EgjXcY1HAuLdq6n https://cassyni.com/events/U11fz8hQKc92PzbxXwHFuX?videoPreview=1 Kidney Organoids from Petri Dish to Transplantationnohttps://cassyni.com/events/U11fz8hQKc92PzbxXwHFuX?videoPreview=12022-10-19T14:00:00+00:002431.08Imperial College Renal and Transplant CentreNo abstracthttps://cassyni-user-files-prod.s3.amazonaws.com/pbhEL6EgjXcY1HAuLdq6n https://cassyni.com/events/6m8gzjsqSvKiGEcnfP57kh/abstract https://cassyni-user-files-prod.s3.amazonaws.com/9rGsoavwqEACratLdmvbPL https://cassyni.com/slides/outline/7FnJ3RXMtNsmG19gFpMv21 https://cassyni.com/events/7FnJ3RXMtNsmG19gFpMv21/abstract https://cassyni-user-files-prod.s3.amazonaws.com/XpzG3Lu3LMaqMiobyFehyg https://cassyni.com/events/7FnJ3RXMtNsmG19gFpMv21?videoPreview=1 On the transitivity of Logical Consequence without Assuming Monotonicitynohttps://cassyni.com/events/7FnJ3RXMtNsmG19gFpMv21?videoPreview=12024-02-28T15:00:00+00:004404.04Logica UniversalisWe generalize Ripley’s results on the transitivity of consequence relation, without assuming a logic to be monotonic. Following Gabbay, we assume nonmonotonic consequence relation to be inclusive and cautious monotonic, and figure out the implications between different forms of transitivity of logical consequence. Weaker frameworks without inclusiveness or cautious monotonicity are also discussed. The paper may provide basis for the study of both non-transitive logics and nonmonotonic ones.https://cassyni-user-files-prod.s3.amazonaws.com/XpzG3Lu3LMaqMiobyFehyg https://cassyni.com/slides/outline/peeXuQb4Lngs8uSeuN82Z https://cassyni.com/events/peeXuQb4Lngs8uSeuN82Z/abstract https://cassyni-user-files-prod.s3.amazonaws.com/XGZCQLHCpKjvAWdXbiYiaz https://cassyni.com/events/peeXuQb4Lngs8uSeuN82Z?videoPreview=1 Digital twins in mechanics and medicinenohttps://cassyni.com/events/peeXuQb4Lngs8uSeuN82Z?videoPreview=12022-10-05T14:00:00+00:002370.88Data-Centric Engineering JournalWe review recent advances in the development of digital twins for mechanics and medicine and discuss challenges ahead. We provide applications to cancer treatment and prognosis, surgical simulation, chemical vapour deposition and other engineering processes and systems.https://cassyni-user-files-prod.s3.amazonaws.com/XGZCQLHCpKjvAWdXbiYiaz https://cassyni.com/events/Q4JRZNHGf5TE69QG2e3Pp1/abstract https://cassyni-user-files-prod.s3.amazonaws.com/2vdrcwKCeYT7erDMrQfyyG https://cassyni.com/events/Ge6mvQpLE5Q37kcpAwqUtd/abstract https://cassyni-user-files-prod.s3.amazonaws.com/AXyRzx7YNCcNxFSq3HwZz6 https://cassyni.com/events/5HfToPhKygQj3sED7UyzM3/seminar/qa https://cassyni.com/slides/outline/5HfToPhKygQj3sED7UyzM3 https://cassyni.com/events/5HfToPhKygQj3sED7UyzM3/abstract https://cassyni-user-files-prod.s3.amazonaws.com/BVvAnQN4UBe2bRQGkJuEBx https://cassyni.com/events/5HfToPhKygQj3sED7UyzM3?videoPreview=1 Scattering kernel of an array of floating ice floes: application to water wave transport in the marginal ice zonenohttps://cassyni.com/events/5HfToPhKygQj3sED7UyzM3?videoPreview=12024-06-20T07:00:00+00:003069.6Royal Society PublishingA radiative transfer model of water wave scattering in the marginal ice zone is considered. In this context, wave energy redistribution across the directional components of the spectrum as a result of scattering by the constituent ice floes is typically modelled via a scattering kernel describing the far-field directionality of the scattered wave field produced by a single floe in isolation. Recognizing the potential importance of the floe size distribution (FSD) on wave scattering, we propose an enhanced scattering kernel constructed from the far-field scattering pattern of a circular array of floes. This is achieved by solving the self-consistent multiple scattering of a time-harmonic plane wave by a large array of floating circular floes with radii sampled from a prescribed FSD. A fast multipole method is implemented to accelerate the numerical estimation of the solution. Simulations are then conducted to characterize the properties of the scattering kernel for a range of configurations. It is found that the scattering kernel obtained for a wide array has a large, narrow transmission peak in the forward direction, while it uniformizes low-amplitude scattered waves in other directions. An idealized application to radiative transfer theory is also considered.https://cassyni-user-files-prod.s3.amazonaws.com/BVvAnQN4UBe2bRQGkJuEBx https://cassyni.com/events/4JNFi2QH6mJaP7QD1WWfY9/seminar/qa https://cassyni.com/slides/outline/4JNFi2QH6mJaP7QD1WWfY9 https://cassyni.com/events/4JNFi2QH6mJaP7QD1WWfY9/abstract https://cassyni-user-files-prod.s3.amazonaws.com/97nARkUQ1EWH1EWCD2QoHY https://cassyni.com/events/4JNFi2QH6mJaP7QD1WWfY9?videoPreview=1 A 32-vertex generalization of the logical square: "Logical Lantern" for propositions in V.I. Markin's Universal language for traditional positive syllogistic theoriesnohttps://cassyni.com/events/4JNFi2QH6mJaP7QD1WWfY9?videoPreview=12024-05-29T14:00:00+00:003365.04Logica UniversalisIn this work is constructed a visual representation for logical relations (contradiction, subalternation, contrariety, subcontrariety) among propositions about each of the possible relations between two non-empty sets. Those relations between sets are equity, strict inclusion, reversed strict inclusion, intersection, exclusion and their combinations (disjunctions); also is used the constant of falsity "none". This representation follows the results by V.I. Markin, who created a universal language for traditional positive syllogistic theories. This language includes syllogistic constants for propositions about each of the 32 possible relations between two non-empty sets (5 basic constants; complex constants, constructed from basic ones; constants for truth and falsity). Among these 32 constants are the traditional vertices of the square of opposition: A ("All S are P"), E ("No S are P"), I ("Some S are P"), O ("Some S are not P"). The proposed scheme shows contradiction and subalternation and allows to deduce contrariety and subcontrariety relations among the propositions in question. It allows to easily find all the propositions that are in a given relation with some (arbitrary) chosen proposition. It also allows to find the relation between two chosen propositions. The scheme also helps to think about the square of opposition and similar diagrams on a meta level. Among the things it helps to think about are relations that are similar to those in the square of opposition, although not themselves present in the square. They are what we called "exhaustive n-place contrariety" and "exhaustive n-place subcontrariety" (n is a natural number, n is greater than 2) -- logical relations that are similar to usual contrariety (subcontrariety), but hold among more than two propositions and have an additional property: all the n propositions in this relation taken together are both truth-incompatible and falsity-incompatible. The proposed scheme can be used as a whole, or in parts (in a reduced way) - as diagrams that would show the logical relations among some but not all the possible propositions about relations of two non-empty sets. Such diagrams can be seen as variations of the Lantern, and the Lantern -- as their generalization. One of the variations is the square of opposition, one more -- Blanché hexagon. Other possible variations are more or less similar to the ones just mentioned and can have the same or different properties, making the Lantern -- together with V.I. Markin's Universal language for traditional positive syllogistic theories, on which the Lantern is based, -- a "common denominator", an instrument to compare and study the properties of different diagrams.https://cassyni-user-files-prod.s3.amazonaws.com/97nARkUQ1EWH1EWCD2QoHY https://cassyni.com/slides/outline/EfywgNzJKNvzuchM2cTZDf https://cassyni.com/events/EfywgNzJKNvzuchM2cTZDf/abstract https://cassyni-user-files-prod.s3.amazonaws.com/NkDLeqz43FmLZNUzGro9En https://cassyni.com/events/EfywgNzJKNvzuchM2cTZDf?videoPreview=1 Nonlinear parametric models of viscoelastic fluid flows with SINDynohttps://cassyni.com/events/EfywgNzJKNvzuchM2cTZDf?videoPreview=12023-12-01T14:00:00+00:00890.24Brunton LabReduced-order models have been widely adopted in fluid mechanics, particularly in the context of Newtonian fluid flows. These models offer the ability to predict complex dynamics, such as instabilities and oscillations, at a considerably reduced computational cost. In contrast, the reduced-order modeling of non-Newtonian viscoelastic fluid flows remains relatively unexplored. This work leverages the sparse identification of nonlinear dynamics (SINDy) algorithm to develop interpretable reduced-order models for a broad class of viscoelastic flows. In particular, we explore a benchmark oscillatory viscoelastic flow on the four-roll mill geometry using the classical Oldroyd-B fluid. This flow exemplifies many canonical challenges associated with non-Newtonian flows, including transitions, asymmetries, instabilities, and bifurcations arising from the interplay of viscous and elastic forces, all of which require expensive computations in order to resolve the fast timescales and long transients characteristic of such flows. First, we demonstrate the effectiveness of our data-driven surrogate model in predicting the transient evolution on a simplified representation of the dynamical system. We then describe the ability of the reduced-order model to accurately reconstruct spatial flow field in a basis obtained via proper orthogonal decomposition. Finally, we develop a fully parametric, nonlinear model that captures the dominant variations of the dynamics with the relevant nondimensional Weissenberg number. This work illustrates the potential to reduce computational costs and improve design, optimization, and control of a large class of non-Newtonian fluid flows with modern machine learning and reduced-order modeling techniques.https://cassyni-user-files-prod.s3.amazonaws.com/NkDLeqz43FmLZNUzGro9En https://cassyni.com/slides/outline/FAdYj4dpkqV3uPEEd3kMUy https://cassyni.com/events/FAdYj4dpkqV3uPEEd3kMUy/abstract https://cassyni-user-files-prod.s3.amazonaws.com/RMFDn1xZjjZ1tpvp4T9pTY https://cassyni.com/events/FAdYj4dpkqV3uPEEd3kMUy?videoPreview=1 Deep Networks and the Multiple Manifold Problemnohttps://cassyni.com/events/FAdYj4dpkqV3uPEEd3kMUy?videoPreview=12022-10-07T14:00:00+00:004098.56AI Institute in Dynamic SystemsData in science and engineering often exhibit nonlinear, low-dimensional structure, due to the physical laws that govern data generation. In this talk, we study how deep neural networks interact with structured data: + When can we guarantee to fit and generalize? How do the resources (depth, width, data) required depend on the complexity of the data? How can we leverage physical prior knowledge to reduce these resource requirements? Our main mathematical result is a guarantee of generalization for a model classification problem involving data on low-dimensional manifolds — we prove that for networks of polynomial width, with polynomially many samples, randomly initialized gradient descent rapidly converges to a solution which correctly labels every point on the two manifolds. To our knowledge this is the first such result for deep networks on data which are not linearly separable. We highlight intuitions about the roles of depth, width, sample complexity, and the geometry of feature representations, which may be useful in analyzing other problems involving low-dimensional structure (e.g., model discovery). We illustrate these ideas through applied problems in astrophysics and computer vision. In these settings, we further suggest how incorporating physical prior knowledge can reduce the resources (architecture, data) required for learning, leading to more efficient and interpretable learning architectures.https://cassyni-user-files-prod.s3.amazonaws.com/RMFDn1xZjjZ1tpvp4T9pTY https://cassyni.com/slides/outline/9jVuDYX3voPyWWz128kZVX https://cassyni.com/events/9jVuDYX3voPyWWz128kZVX/abstract https://cassyni-user-files-prod.s3.amazonaws.com/U4p3Xn1x9kbbmUp9n1YSjY https://cassyni.com/events/9jVuDYX3voPyWWz128kZVX?videoPreview=1 From PINNs to DeepOnets: Approximating functions, functionals, and operators using deep neural networks for diverse applicationsnohttps://cassyni.com/events/9jVuDYX3voPyWWz128kZVX?videoPreview=12020-10-02T14:00:00+00:004732.92AI Institute in Dynamic SystemsNo abstracthttps://cassyni-user-files-prod.s3.amazonaws.com/U4p3Xn1x9kbbmUp9n1YSjY https://cassyni.com/slides/outline/N5jdVGD4JcAZYfvDH4FjGH https://cassyni.com/events/N5jdVGD4JcAZYfvDH4FjGH/abstract https://cassyni-user-files-prod.s3.amazonaws.com/B3k9kUA4EjaUDV1AKBVfyQ https://cassyni.com/events/N5jdVGD4JcAZYfvDH4FjGH?videoPreview=1 Upper boundary on tree cover at global drylandsnohttps://cassyni.com/events/N5jdVGD4JcAZYfvDH4FjGH?videoPreview=12024-06-08T16:00:00+00:001140.08New Phytologist Foundation In a recent Tansley Review, Holdo and Nippert (2023) provided a comprehensive analysis of existing models that explain tree-grass coexistence along precipitation gradients in savannas. They proposed three key elements that a definitive savanna model should include and predicted the upper boundary pattern of tree cover based on the ‘Sankaran curve’ depending on soil texture. We tested this boundary pattern of tree cover in drylands using global field data (98 sites from 25 countries and six continents) accounting from a wide range of environmental conditions and grazing pressures. We found that the upper boundary on tree cover in global drylands increases with mean annual precipitation before reaching a threshold of 453 mm. Increasing grazing pressure significantly decreased this upper limit. However, the upper boundary on tree cover did not stabilize but instead decreased beyond this precipitation threshold. Our findings partially support the three coexistence mechanisms proposed by Holdo and Nippert and indicate some features that may be specific for water-limited rangelands: a lower precipitation threshold for the upper boundary on tree cover, a declining tree cover beyond the threshold, and an interplay between resource- and disturbance-based mechanisms. Overall, our findings advance our understanding of tree-grass coexistence in drylands and provide new elements to develop a definitive model of such coexistence across terrestrial ecosystems.https://cassyni-user-files-prod.s3.amazonaws.com/B3k9kUA4EjaUDV1AKBVfyQ https://cassyni.com/slides/outline/QYyeigSgVtw3ucPmpkAMzD https://cassyni.com/events/QYyeigSgVtw3ucPmpkAMzD/abstract https://cassyni-user-files-prod.s3.amazonaws.com/8JUp3n3Fa1c4v78jCxLWS https://cassyni.com/events/QYyeigSgVtw3ucPmpkAMzD?videoPreview=1 Habitat structural complexity predicts cognitive performance and behavior in western mosquitofishnohttps://cassyni.com/events/QYyeigSgVtw3ucPmpkAMzD?videoPreview=12024-06-29T17:00:00+00:001363.24Royal Society PublishingUrban stream syndrome alters stream habitat complexity. We define habitat complexity as the degree of variation in physical habitat structure, with increasing variation equating to higher complexity. Habitat complexity affects species composition and shapes animal ecology, physiology, behavior, and cognition. We used a delayed detour test to measure whether cognitive processes (motor self-regulation) and behavior (risk-taking) of female Western mosquitofish, Gambusia affinis, varied with habitat structural complexity (low, moderate, and high) that was quantified visually for nine populations. We predicted that motor self-regulation and risk-taking behavior would increase with increasing habitat complexity, yet we found support for the opposite. Lower complexity habitats offer less refuge potentially leading to higher predation pressure and selecting for greater risk-taking by fish with higher motor self-regulation. Our findings provide insight into how habitat complexity can shape cognitive processes and behavior and offers a broader understanding of why some species may tolerate conditions of urbanized environments.https://cassyni-user-files-prod.s3.amazonaws.com/8JUp3n3Fa1c4v78jCxLWS https://cassyni.com/events/H9Fb2Rjov2dY9aCsGaYjY9/seminar/qa https://cassyni.com/slides/outline/H9Fb2Rjov2dY9aCsGaYjY9 https://cassyni.com/events/H9Fb2Rjov2dY9aCsGaYjY9/abstract https://cassyni-user-files-prod.s3.amazonaws.com/KnrArfNHwPnxP4hQ8dbtfg https://cassyni.com/events/H9Fb2Rjov2dY9aCsGaYjY9?videoPreview=1 Nano Engineered Fiber reinforced composites for structural applicationsnohttps://cassyni.com/events/H9Fb2Rjov2dY9aCsGaYjY9?videoPreview=12024-06-24T14:00:00+00:003465.04Department of AeronauticsFiber reinforced composites are widely used in structural applications, especially in aerospace, automotive and other transport sectors because of the flexibility in tailoring its properties for the required applications. Nano materials are the class of materials which can enhance the different matrix properties and can be exploited for wide applications in engineering applications. One of our research activity is to enhance the matrix properties for its mechanical, thermal and other functional properties and study the performance of fiber reinforced composites which are filled with nano fillers. The presentation covers the topics on the influence of nano fillers on the base material and on fiber reinforced composites for extreme load conditions, which include, quasi-static to high strain rate conditions, impact resistant structures, shape memory polymer composites, structural crashworthiness, etchttps://cassyni-user-files-prod.s3.amazonaws.com/KnrArfNHwPnxP4hQ8dbtfg https://cassyni.com/events/XxhiQw9Z5mEtQBvEnd26QD/abstract https://cassyni-user-files-prod.s3.amazonaws.com/86VtJnT7k8Xp9TDfvh8CXG https://cassyni.com/slides/outline/SXa4uR2nFj9p1Kg1Bi2JQm https://cassyni.com/events/SXa4uR2nFj9p1Kg1Bi2JQm/abstract https://cassyni-user-files-prod.s3.amazonaws.com/NWPN8UBzJaR1YFn7z8toKC https://cassyni.com/events/SXa4uR2nFj9p1Kg1Bi2JQm?videoPreview=1 Radiation therapy with phenotypic medicine: towards N-of-1 personalizationnohttps://cassyni.com/events/SXa4uR2nFj9p1Kg1Bi2JQm?videoPreview=12024-08-27T11:00:00+00:00685.0Research Seminars by Springer NatureCurrent radiotherapy (RT) treatment strategies are developed based on decades-old radiobiological modeling, preclinical work, and population-driven trials. The pre-determined total dose is divided into smaller dose fractions and delivered over several weeks. The treatment responses are typically assessed months after the treatment. However, due to the presence of heterogeneity, the conventional one-dose-fits-all strategy may pose a challenge to optimising outcome. A personalized regimen based on individual response will be favoured. As an alternative strategy, we are proposing a small-data AI-derived phenotypic medicine (PM) platform that does not to any model training and testing in guiding clinicians to dose patient based on individual treatment response in real-time with their own data. It potentially reduces unnecessary toxicity for good responders and prevents inadequate disease control for poor responders. https://cassyni-user-files-prod.s3.amazonaws.com/NWPN8UBzJaR1YFn7z8toKC https://cassyni.com/events/FfJmtNoEbexsirDkR9sKfB/seminar/qa https://cassyni.com/slides/outline/FfJmtNoEbexsirDkR9sKfB https://cassyni.com/events/FfJmtNoEbexsirDkR9sKfB/abstract https://cassyni-user-files-prod.s3.amazonaws.com/3x1TvMVrHLPdZSr1U4tf4J https://cassyni.com/events/FfJmtNoEbexsirDkR9sKfB?videoPreview=1 The microbiome in cancer immunotherapynohttps://cassyni.com/events/FfJmtNoEbexsirDkR9sKfB?videoPreview=12024-09-18T14:00:00+00:005125.28Research Seminars by Springer NatureThe microbiota can influence the immune system and modulate response to cancer immunotherapy. In this webinar, our speakers will introduce the role of the microbiome in cancer immunotherapy, discussing recent developments in the field. The presentations will be followed by a panel discussion and Q&A session. The webinar will be hosted by Nature Cancer and Nature Communications editors.https://cassyni-user-files-prod.s3.amazonaws.com/3x1TvMVrHLPdZSr1U4tf4J https://cassyni.com/slides/outline/YTNwaFJxvaiiDeukaj94aR https://cassyni.com/events/YTNwaFJxvaiiDeukaj94aR/abstract https://cassyni-user-files-prod.s3.amazonaws.com/2jQhDGdVgJoyBM5UJJgn4N https://cassyni.com/events/YTNwaFJxvaiiDeukaj94aR?videoPreview=1 Novel rebreathing adaptation extends dive time in a semi-aquatic lizardnohttps://cassyni.com/events/YTNwaFJxvaiiDeukaj94aR?videoPreview=12024-10-05T12:00:00+00:001615.0Royal Society PublishingBubble use evolved in many small invertebrates to enable underwater respiration but, until recently, there has been no evidence that vertebrate animals use bubbles in a similar manner. Only one group of vertebrates, semi-aquatic Anolis lizards, may be an exception: these lizards dive underwater when threatened and, while underwater, rebreathe a bubble of air over their nostrils. Although it seems that rebreathing should be adaptive, possibly functioning to extend the time that lizards remain in underwater refugia, this has not been empirically tested. Here, I demonstrate that rebreathing serves to extend dive time in a semi-aquatic anole, Anolis aquaticus. I prevented formation of normal rebreathing bubbles by applying a commercial emollient where bubbles form on the skin to assess the impact of bubbles on rebreathing cycles, gular pumps, and dive times. Lizards that were allowed to rebreathe normally remained underwater an average of 32% longer than those with impaired rebreathing, indicating a functional role of rebreathing in underwater respiration. Unlike rebreathing, gular pumping was unaffected by treatment and may warrant further research regarding its role in supplementing underwater respiration. This study provides evidence that vertebrates use bubbles to respire underwater and raises questions about adaptive mechanisms and potential bio-inspired applications. https://cassyni-user-files-prod.s3.amazonaws.com/2jQhDGdVgJoyBM5UJJgn4N https://cassyni.com/slides/outline/8FcLJkcFR9ap3y9uewqmA5 https://cassyni.com/events/8FcLJkcFR9ap3y9uewqmA5/abstract https://cassyni-user-files-prod.s3.amazonaws.com/CwSHBZp3ZFQ6rZLs46E1e6 https://cassyni.com/events/8FcLJkcFR9ap3y9uewqmA5?videoPreview=1 Widespread within-person adaptation in the human gut microbiomenohttps://cassyni.com/events/8FcLJkcFR9ap3y9uewqmA5?videoPreview=12021-12-08T12:00:00+00:00664.04Microbiome Virtual International Forum Gut microbiota plays an essential role in regulating human health. How host environment drives microbial evolution was studied in some bacterial species, however, some studies concluded long-term purifying selection while others demonstrated evidence of adaptation. To address this problem, we broadly investigated the within-person evolution of 64 gut commensal species in healthy subjects. We found that most (24 of 27) species with sufficient genetic variation underwent recent adaptation, evidenced by parallel evolution (PE). This finding was supported by three lines of evidence on PE mutations (significantly more than expected, significantly higher dN/dS, significant enrichment of truncations). Moreover, signal transduction pathways underwent the strongest and most widespread positive selection. One striking example is an HTH-type transcriptional regulator (msmR) regulating carbohydrate transportation that underwent widespread PE in six species across 28 people, potentially driven by host diet changes. We resolved the previous debate of gut microbiota evolution showing widespread within-host adaptation, and identified adaptive mutations to guide precise microbiome manipulations.https://cassyni-user-files-prod.s3.amazonaws.com/CwSHBZp3ZFQ6rZLs46E1e6 https://cassyni.com/slides/outline/3K8Hqv912a3nesSZeU8mRw https://cassyni.com/events/3K8Hqv912a3nesSZeU8mRw/abstract https://cassyni-user-files-prod.s3.amazonaws.com/XLZR3Q9TWC61zoVRzqeMVG https://cassyni.com/events/3K8Hqv912a3nesSZeU8mRw?videoPreview=1 Gut metagenome associations with extensive digital health data in a volunteer-based Estonian microbiome cohortnohttps://cassyni.com/events/3K8Hqv912a3nesSZeU8mRw?videoPreview=12022-05-10T10:00:00+00:00638.0Microbiome Virtual International Forum As part of the Estonian Biobank, we established the Estonian Microbiome Cohort which includes stool, oral and plasma samples from 2509 participants and is supplemented with multi-omic measurements, questionnaires, and regular linkages to national electronic health records. Here we analyze stool data from deep metagenomic sequencing together with rich phenotyping, including 71 diseases, 136 medications, 21 dietary questions, 5 medical procedures, and 19 other factors. We identify numerous relationships (n = 3262) with different microbiome features. In this study, we extend the understanding of microbiome-host interactions using electronic health data and show that long-term antibiotic usage, independent from recent administration, has a significant impact on the microbiome composition, partly explaining the common associations between diseases.https://cassyni-user-files-prod.s3.amazonaws.com/XLZR3Q9TWC61zoVRzqeMVG https://cassyni.com/slides/outline/2pUgoEVUb7Vjf6ug42qyAd https://cassyni.com/events/2pUgoEVUb7Vjf6ug42qyAd/abstract https://cassyni-user-files-prod.s3.amazonaws.com/VuwTAgQyvGKjHKdQPBCm3c https://cassyni.com/events/2pUgoEVUb7Vjf6ug42qyAd?videoPreview=1 Replacing wakes with large-scale streaks in wind farmsnohttps://cassyni.com/events/2pUgoEVUb7Vjf6ug42qyAd?videoPreview=12022-11-23T13:00:00+00:003368.04Department of Aeronautics and AstronauticsStreamwise streaks are elongated regions of velocity excess and deficit ubiquitous in transitional and turbulent wall-bounded flows. Their prevalence has been explained by linear analyses showing that they are the most amplified disturbances in linearly stable laminar and turbulent shear flows. I will show that wind turbines can be used as "streak generators" to replace the (low-speed) rotor wakes with coherent high-speed streaks. When applied to wind farms, this approach leads to significant gains in the total power extracted from the wind. Maximum power gains are obtained when the transverse spacing of the wind turbines and of the large-scale forced streaks is of the same order as the spacing of the large-scale coherent streaks which are naturally amplified (in the absence of turbines) in turbulent boundary layers.https://cassyni-user-files-prod.s3.amazonaws.com/VuwTAgQyvGKjHKdQPBCm3c https://cassyni.com/slides/outline/AECkVVCMAyoa9gS91uhhad https://cassyni.com/events/AECkVVCMAyoa9gS91uhhad/abstract https://cassyni-user-files-prod.s3.amazonaws.com/UVqC2UBByouW4Lokz6k48v https://cassyni.com/events/AECkVVCMAyoa9gS91uhhad?videoPreview=1 BugSigDB: A Comprehensive Database of Published Microbial Signatures for Epidemiological Analysis of Microbiome Datanohttps://cassyni.com/events/AECkVVCMAyoa9gS91uhhad?videoPreview=12022-11-08T12:00:00+00:0060.84Microbiome Virtual International Forum Most microbiome studies report “signatures” of differentially abundant microbial taxa for a disease or exposure of interest, but heterogeneity in how complex methods and results are reported make comparisons between studies difficult. A signature represents statistically different bacterial taxa identified in a given study and represents a summary of a study’s findings. These signatures can be assessed across studies for consistency and agreement. BugSigDB is a manually curated database of microbial signatures collected from published microbiome differential abundance studies. Key information for each study is curated including study design, sample size, participant information, laboratory methods, and statistical methods in a structured, standardized format. BugSigDB is open source and available for researchers to use and contribute to. As of January 11th, 2022 it contains 2,107 microbial signatures curated from 522 published microbiome research articles. We present an applied example of use of BugSigDB gut microbiome signatures for COVID-19. Analysis of 132 signatures from 32 studies of COVID-19 and the gut microbiome reveal significant co-occurrence of several bacterial taxa within the phylum Firmicutes along with Actinobacteria, Bacteriodetes, and Proteobacteria (Figure 1). Across these studies, the genera Bacteroides and Alistipes were statistically found to be in decreased abundance among COVID-19 patients. bugsigdbr, an accompanying open source R/Bioconductor package, provides signatures and accompanying data downloads in a tidy data format. Data can also be accessed via a semantic wiki web interface at https://bugsigdb.org. Together, they allow for efficient systematic analysis of findings from microbiome studies across a variety of diseases and conditions of interest.https://cassyni-user-files-prod.s3.amazonaws.com/UVqC2UBByouW4Lokz6k48v https://cassyni.com/slides/outline/L7CTXnejMVod9g8Zp3QWMB https://cassyni.com/events/L7CTXnejMVod9g8Zp3QWMB/abstract https://cassyni-user-files-prod.s3.amazonaws.com/BpeCTURUje3AKhKWbJUXf4 https://cassyni.com/events/L7CTXnejMVod9g8Zp3QWMB?videoPreview=1 Gut microbiota manipulation in neurodevelopmental disorders: implication from animal models of infantile epilepsynohttps://cassyni.com/events/L7CTXnejMVod9g8Zp3QWMB?videoPreview=12023-12-19T11:00:00+00:00660.0Microbiome Virtual International Forum Infantile epileptic spasms syndrome (IESS) is a devastating early-onset epileptic encephalopathy with a poor neurodevelopmental prognosis. Accumulating evidence proposes an important role of gut microbiota in neurodevelopmental disorders via microbiota-gut-brain axis. In a neonatal rat model of IESS, we show both the ketogenic diet and antibiotic administration to reduce seizure frequency and to be associated with improved developmental outcomes. Seizure reductions were accompanied by specific gut microbial alterations including increases in Streptococcus thermophilus and Lactococcus lactis. Mimicking the fecal microbial alterations in a targeted probiotic, we administered these species in a 5:1 ratio. Probiotic administration reduced seizures and improved locomotor activities in control diet-fed animals, similar to KD-fed animals while a negative control (Ligilactobacillus salivarius) had no impact. These results suggest that a targeted microbiota manipulation could improve behavior outcome in infantile epilepsy and provides new insights into microbiota manipulation as a therapeutic avenue for neurodevelopmental disorders. Link to OA paper: https://www.thelancet.com/journals/ebiom/article/PIIS2352-3964(22)00017-2/fulltexthttps://cassyni-user-files-prod.s3.amazonaws.com/BpeCTURUje3AKhKWbJUXf4 https://cassyni.com/slides/outline/M6Vfd9wnEQumpRxZv1sqA5 https://cassyni.com/events/M6Vfd9wnEQumpRxZv1sqA5/abstract https://cassyni-user-files-prod.s3.amazonaws.com/67sV42GHkv8ZWe5dVXckyC https://cassyni.com/events/M6Vfd9wnEQumpRxZv1sqA5?videoPreview=1 Molecular mechanisms of microbial modulation of skin homeostasisnohttps://cassyni.com/events/M6Vfd9wnEQumpRxZv1sqA5?videoPreview=12024-04-17T13:00:00+00:001846.04Microbiome Virtual International Forum The human skin harbors an abundant microbial ecosystem with bidirectional metabolic exchanges supporting symbiotic and commensal functions. Metagenomic analyses of the diverse skin sites in healthy humans demonstrate that contrasting forces of the skin’s biogeography and individual characteristics shape the skin microbiome and the dynamics of its bacteria, fungi, and viruses. However, we have shown that shifts in the ecological properties of the skin microbiome are significantly associated with aging, skin disease, disease severity, and monogenic skin and immune disorders. We have used a variety of computational and functional approaches, including metagenomics, CRISPRi screening, organoid platforms, transcriptomic and spatial transcriptomics, and other technologies to probe genetic and functional diversity of the skin microbiome.https://cassyni-user-files-prod.s3.amazonaws.com/67sV42GHkv8ZWe5dVXckyC https://cassyni.com/events/6H3YEeY34gJ9WVfruN46cM/seminar/qa https://cassyni.com/slides/outline/6H3YEeY34gJ9WVfruN46cM https://cassyni.com/events/6H3YEeY34gJ9WVfruN46cM/abstract https://cassyni-user-files-prod.s3.amazonaws.com/FLTH9vEqw4HsA5CT8fGQnS https://cassyni.com/events/6H3YEeY34gJ9WVfruN46cM?videoPreview=1 And you thought doing soft particle mechanics is relaxing?nohttps://cassyni.com/events/6H3YEeY34gJ9WVfruN46cM?videoPreview=12024-09-19T13:00:00+00:004362.96Granular MatterThe deformability of particles affects the bulk behavior of their packings. For example, when compressive stresses applied to a packing become similar to the moduli of the particles in the packing, new bulk material behavior appears. In this webinar we will discuss experimental examples of such effects. Studies on "soft" particle packings such as hydrogel spheres reveal that by compressing them, we can see their relaxation behavior. Surprisingly, this relaxation dynamics is not always the same as the microscopic relaxation timescale in the hydrogel itself. Shearing such particles reveals such intrinsic viscoelastic behavior, but also compression at the single grain level. Relaxation dynamics at the particle scale may so be responsible for slow bulk relaxation dynamics such as creep, also observed in hydrogel particle packings. We will discuss some recent published and unpublished work on this topichttps://cassyni-user-files-prod.s3.amazonaws.com/FLTH9vEqw4HsA5CT8fGQnS https://cassyni.com/slides/outline/PZjgraBQRhgGBNS8ThnTt1 https://cassyni.com/events/PZjgraBQRhgGBNS8ThnTt1/abstract https://cassyni-user-files-prod.s3.amazonaws.com/QFYupLAVNhVMxgYtq7gVqQ https://cassyni.com/events/PZjgraBQRhgGBNS8ThnTt1?videoPreview=1 An efficient method for high molecular weight bacterial DNA extraction suitable for shotgun metagenomics from skin swabsnohttps://cassyni.com/events/PZjgraBQRhgGBNS8ThnTt1?videoPreview=12023-09-19T14:00:00+00:00904.88Microbiome Virtual International Forum The human skin microbiome represents a variety of complex microbial ecosystems that play a key role in host health. Molecular methods to study these communities have been developed but have been largely limited to low-throughput quantification and short amplicon-based sequencing, providing limited functional information about the communities present. Shotgun metagenomic sequencing has emerged as a preferred method for microbiome studies as it provides more comprehensive information about the species/strains present in a niche and the genes they encode. However, the relatively low bacterial biomass of skin, in comparison to other areas such as the gut microbiome, makes obtaining sufficient DNA for shotgun metagenomic sequencing challenging. Here we describe an optimised high-throughput method for extraction of high molecular weight DNA suitable for shotgun metagenomic sequencing. We validated the performance of the extraction method, and analysis pipeline on skin swabs collected from both adults and babies. The pipeline effectively characterised the bacterial skin microbiota with a cost and throughput suitable for larger longitudinal sets of samples. Application of this method will allow greater insights into community compositions and functional capabilities of the skin microbiome.https://cassyni-user-files-prod.s3.amazonaws.com/QFYupLAVNhVMxgYtq7gVqQ https://cassyni.com/slides/outline/WUp9W9Eka7S3gBRhq9MQ2h https://cassyni.com/events/WUp9W9Eka7S3gBRhq9MQ2h/abstract https://cassyni-user-files-prod.s3.amazonaws.com/KcAKCAXk5ZwKsadjaWT1ot https://cassyni.com/events/WUp9W9Eka7S3gBRhq9MQ2h?videoPreview=1 Genomic analysis of cultivated infant microbiomes identifies Bifidobacterium 2’-fucosyllactose utilization can be facilitated by co-existing speciesnohttps://cassyni.com/events/WUp9W9Eka7S3gBRhq9MQ2h?videoPreview=12023-04-19T11:00:00+00:00592.0Microbiome Virtual International Forum Human milk oligosaccharides (HMOs) ensure proper infant gut microbiome establishment. Isolate studies have revealed the genetic basis for HMO metabolism, but they exclude the possibility of HMO assimilation via synergistic interactions involving multiple organisms. Here, we investigated microbiome responses to 2'-fucosyllactose (2’FL), a prevalent HMO and infant formula additive, by establishing individualized microbiomes using fecal samples from three different infants as the inocula. Bifidobacterium breve, a prominent member of infant microbiomes, typically cannot metabolize 2’FL. Using metagenomic data, we predicted that extracellular fucosidases encoded by co-existing members such as Ruminococcus gnavus initiate 2’FL breakdown, thus critical for B. breve’s growth. Using both targeted co-cultures and by supplementation of R. gnavus into one microbiome, we show that R. gnavus can promote extensive growth of B. breve through the release of lactose from 2’FL. Overall, microbiome cultivation combined with genome-resolved metagenomics demonstrated that HMO utilization can vary with an individual’s microbiome. Link to OA paper: https://www.biorxiv.org/content/10.1101/2023.03.10.532136v1https://cassyni-user-files-prod.s3.amazonaws.com/KcAKCAXk5ZwKsadjaWT1ot https://cassyni.com/slides/outline/WyTkYptH1Zz6fwxbRaeCJ1 https://cassyni.com/events/WyTkYptH1Zz6fwxbRaeCJ1/abstract https://cassyni-user-files-prod.s3.amazonaws.com/WuEfG3i2oBRsx5TQV9g5rW https://cassyni.com/events/WyTkYptH1Zz6fwxbRaeCJ1?videoPreview=1 Combustion instabilities in single and multi-flame systemsnohttps://cassyni.com/events/WyTkYptH1Zz6fwxbRaeCJ1?videoPreview=12024-02-28T11:00:00+00:003429.04Department of Aeronautics and AstronauticsGas turbine engines are an integral part of the global energy production and infrastructure. The ability to rapidly scale their power output makes them an attractive partner to intermittent renewable energy sources, meaning they are likely to retain their importance throughout the energy transition. They are also widely used for propulsion, with their high power to weight ratio, and their fuels’ energy to weight ratio making them difficult to replace for long distance transportation. There has long been a focus to reduce the emission of pollutants such as nitrous oxides (NOx) from gas turbines, but the impending climate crisis means there is a growing need to also eliminate the emission of carbon dioxide (CO2). One promising method of achieving this is to switch from hydrocarbon-based fuels such as natural gas (mainly composed of methane – CH4), to fuel blends composed of increasing proportions of carbon-free fuels such as hydrogen (H2) and ammonia (NH3). However, switching to these fuels is challenging due to substantially different fuel properties. Designing future gas turbine systems that can operate in a fuel-flexible manner, accepting a wide variety of alternative carbon-free fuels is not straightforward, and hindered by our incomplete understanding of these fuels and some important phenomena which occur during their use, including flame stabilization, combustion instabilities, and harmful emissions. In this talk recent experimental work on thermoacoustic instabilities in single flames and annular combustors will be presented, with an emphasis on the careful excitation of modes of interest, and the effects of realistic boundary conditions. Work will also be presented from a simple axially staged combustor, in which the concept of flexible fueling is briefly explored.https://cassyni-user-files-prod.s3.amazonaws.com/WuEfG3i2oBRsx5TQV9g5rW https://cassyni.com/slides/outline/Uzb7Do9KE8WSXDp8XkXfoT https://cassyni.com/events/Uzb7Do9KE8WSXDp8XkXfoT/abstract https://cassyni-user-files-prod.s3.amazonaws.com/JHokWba8xmijCo1LYdAEXx https://cassyni.com/events/Uzb7Do9KE8WSXDp8XkXfoT?videoPreview=1 Comparative analysis of performance of single-sided and double-sided vibro-impact dampersnohttps://cassyni.com/events/Uzb7Do9KE8WSXDp8XkXfoT?videoPreview=12025-06-24T02:00:00+00:00595.88NODYSWe compare the dynamic behavior and efficiency in mitigating primary structure (PS) vibrations for asymmetric single-sided and symmetric double-sided vibro-impact nonlinear energy sinks (SS and DS VI NES). We show that the performance of the different VI NES types with optimized parameters is similar, but their dynamic behavior differs significantly.https://cassyni-user-files-prod.s3.amazonaws.com/JHokWba8xmijCo1LYdAEXx https://cassyni.com/slides/outline/XTq8TDNwRRGvtAHh5SSJXP https://cassyni.com/events/XTq8TDNwRRGvtAHh5SSJXP/abstract https://cassyni-user-files-prod.s3.amazonaws.com/GKExSVVvcJSS5A22rpAEYE https://cassyni.com/events/XTq8TDNwRRGvtAHh5SSJXP?videoPreview=1 Nonlinear Control of Marine Surface Vehicles without velocity measurementnohttps://cassyni.com/events/XTq8TDNwRRGvtAHh5SSJXP?videoPreview=12025-06-24T10:00:00+00:00945.36NODYSThe paper deals with the tracking control of Marine Surface Vehicles without velocity measurement. An auxiliary filter is used to generate a velocity signal for the tracking error dynamics. Although the filter-based approach has been used before, this paper has two new contributions – unlike in literature, the approach in this paper doesn’t require the acceleration signals for computing the real input force. Secondly, the use of barrier Lyapunov functions has never been explored for marine vehicles when using the filter approach, whereas in this paper, the filter-based approach is combined with the use of barrier Lyapunov functions for improved transient response. Furthermore, unlike in literature on the use of filters without velocity measurement for marine vehicles, the inertia, Coriolis and damping matrices are assumed to be time-varying and external disturbances are also considered. The control law is designed using adaptive control methodology. Model uncertainties are effectively rejected by the nonlinear control law. Closed loop- system stability is proved via Lyapunov Theory. Results from numerical simulations are presented to validate the effectiveness of the proposed approach.https://cassyni-user-files-prod.s3.amazonaws.com/GKExSVVvcJSS5A22rpAEYE https://cassyni.com/slides/outline/U1Hu8RrGMDQHrTz8Rn4LzZ https://cassyni.com/events/U1Hu8RrGMDQHrTz8Rn4LzZ/abstract https://cassyni-user-files-prod.s3.amazonaws.com/BVvKEpwZL63S6JdTyikNSz https://cassyni.com/events/U1Hu8RrGMDQHrTz8Rn4LzZ?videoPreview=1 Is single-mode approximation safe for cubic (nonlinear) structures ?nohttps://cassyni.com/events/U1Hu8RrGMDQHrTz8Rn4LzZ?videoPreview=12025-06-24T11:00:00+00:00776.24NODYSIt has been long known in nonlinear dynamics community that, single mode approximation performs well for primary resonant dynamics of cubic structures, which is in a significant contrast with quadratic/cubic structures (the latter requires more cares for deriving reliable reduced-order models). In this talk, we focus on an inextensible beam model with a weak end stiffness kl and end mass ml, which leads to cubic (inertial) nonlinearity. In the formulation of multi-scale analysis, we revisit single-mode approximation by comparing it with direct perturbation method. The results indicate that single-mode approximation is safe when the system is far from hardening/softening (H/S) transition, as expected. However, when the nonlinear system approaches its H/S transition, both quantitative and qualitative differences arise, meaning that single-mode approximation is not safe for pure cubic structures. This is different from routine perturbation literature.https://cassyni-user-files-prod.s3.amazonaws.com/BVvKEpwZL63S6JdTyikNSz https://cassyni.com/slides/outline/6mQv932hUXayihzxZDrCqj https://cassyni.com/events/6mQv932hUXayihzxZDrCqj/abstract https://cassyni-user-files-prod.s3.amazonaws.com/BNkuyf2gDiuQg4JgrLTEp6 https://cassyni.com/events/6mQv932hUXayihzxZDrCqj?videoPreview=1 Motion Control and Actuation Strategy for a Three-Bar Tensegrity Robotnohttps://cassyni.com/events/6mQv932hUXayihzxZDrCqj?videoPreview=12025-06-24T11:00:00+00:00691.32NODYSTensegrity robots, known for their lightweight and adaptive structures, offer promising applications in planetary exploration and disaster response. This study investigates a three-rod tensegrity structure that, despite its structural simplicity, faces challenges such as unidirectional rolling and low locomotion efficiency. Employing the force density method, we analyze the structure’s geometric configuration and static equilibrium to elucidate its form-finding and force-deformation characteristics. A novel rolling determination method based on center-of-mass shifting, along with a traversal search algorithm, is introduced to optimize rolling modes and locomotion trajectories. Moreover, to balance efficiency with stability, two control strategies—the Velocity-Energy Balanced Actuation Strategy (VEBA) and the Maximum-Velocity Optimization Strategy (MVO)—are proposed and compared against the Minimal-Cable Actuation Strategy (MCA). Experimental validations using an Arduino-controlled prototype demonstrate that multi-cable coordinated actuation enhances rolling efficiency, reduces structural deformation, and improves overall stability.https://cassyni-user-files-prod.s3.amazonaws.com/BNkuyf2gDiuQg4JgrLTEp6 https://cassyni.com/slides/outline/Jd13N55BQsonpQyciKQx2q https://cassyni.com/events/Jd13N55BQsonpQyciKQx2q/abstract https://cassyni-user-files-prod.s3.amazonaws.com/B1GiC9J2tdVLRKLMUBZquQ https://cassyni.com/events/Jd13N55BQsonpQyciKQx2q?videoPreview=1 Noise-Assisted Synchronization in Networks of Coupled Mathieu Oscillatorsnohttps://cassyni.com/events/Jd13N55BQsonpQyciKQx2q?videoPreview=12025-07-09T16:00:00+00:00803.44NODYSStudies of the collective behavior of coupled dynamical agents continue to reveal a broad range of phenomena. Such behavior has been studied by using models such as the Kuramoto model, which can be related to dynamics of, for example, Josephson junctions, laser systems, power grids, and even sociology. In mechanical systems, synchronization is commonly analyzed in limit cycle oscillators, such as clocks or Van-der-Pol oscillators, where analogies with the Kuramoto model can be drawn. Here, the authors analyze a parametrically excited nonlinear Mathieu oscillator network and demonstrate that introducing random interventions can promote synchronous collective behavior. Specifically, in the uncoupled limit, the method of averaging is utilized to show that parametric excitation results in multiple stable periodic orbits. This phase space geometry remains largely intact under moderate coupling strengths and gives rise to a multitude of stable steady states, most of which, most of which correspond to asynchronous behavior. In addition, the emergence of chimera states, where synchronous and asynchronous behaviors coexist, is observed. When weak stochastic input is introduced, the asynchronous behavior is suppressed, and after an initial transient phase, a synchronous collective behavior is found to emerge. Thus, introducing noise (i.e., temporal disorder) to disordered dynamics is found to lead to order. This counterintuitive effect suggests applications in systems ranging from rotating machinery to Josephson junction arrays.https://cassyni-user-files-prod.s3.amazonaws.com/B1GiC9J2tdVLRKLMUBZquQ https://cassyni.com/slides/outline/EfpCzbtyuDNe2kWwKCpuRw https://cassyni.com/events/EfpCzbtyuDNe2kWwKCpuRw/abstract https://cassyni-user-files-prod.s3.amazonaws.com/WyzEWsbJqf67bevZEgB7ve https://cassyni.com/events/EfpCzbtyuDNe2kWwKCpuRw?videoPreview=1 Optimization of runaway electron mitigation by massive material injection in ITER and SPARCnohttps://cassyni.com/events/EfpCzbtyuDNe2kWwKCpuRw?videoPreview=12025-05-22T15:00:00+00:002716.8Journal of Plasma PhysicsDuring tokamak disruptions, strong electric fields can arise which are sufficient to cause electron runaway, whereby electrons are accelerated continuously. In future large-current tokamaks, such as ITER and SPARC, significant runaway electron generation is expected, due to the runaway generation being exponentially sensitive to the pre-disruption plasma current. Should the beam of runaway electrons come in contact with the tokamak wall, its energy can be almost instantly deposited deep into the wall. During disruptions, high heat loads can also arise from heat being transported into the wall when the magnetic surfaces are broken up during the thermal quench. Additionally, if the current decay is too fast or too slow, electromechanical forces caused by eddy or halo currents can cause forces and torques on the tokamak structure. While all of these unwanted aspects of a disruption can individually be addressed by massive material injection, they pose conflicting requirements on the injected material quantity and composition. In this talk, we investigate disruptions mitigated with combined deuterium and noble gas injection in ITER and SPARC. We use multi-objective Bayesian optimization of the densities of the injected material, taking into account limits on the maximum runaway current, the transported fraction of the heat loss, and the current quench time. Regions in the injected material density space corresponding to successful mitigation are found for both machines when optimizing pure deuterium plasma scenarios. When optimizing deuterium-tritium plasma scenarios, on the other hand, simultaneous mitigation of runaway current, transported heat loss and electromechanical forces appear more challenging for ITER than for SPARC.https://cassyni-user-files-prod.s3.amazonaws.com/WyzEWsbJqf67bevZEgB7ve https://cassyni.com/slides/outline/FATp3HYWLfvh2X3pue7hhF https://cassyni.com/events/FATp3HYWLfvh2X3pue7hhF/abstract https://cassyni-user-files-prod.s3.amazonaws.com/RoBPXhJJEMH8iW66odfKVG https://cassyni.com/events/FATp3HYWLfvh2X3pue7hhF?videoPreview=1 The Infinity Two Stellarator Fusion Pilot Plant baseline plasma physics designnohttps://cassyni.com/events/FATp3HYWLfvh2X3pue7hhF?videoPreview=12025-03-27T15:00:00+00:003458.6Journal of Plasma PhysicsIn this set of talks, we provide an assessment of the Infinity Two Fusion Pilot Plant (FPP) baseline plasma physics design. Infinity Two is a four-field period, aspect ratio A = 10, quasi-isodynamic stellarator with improved confinement appealing to a max-J approach, elevated plasma density and high magnetic field ( = 9 T). At the envisioned operating point (800 MW DT fusion), the configuration has robust magnetic surfaces based on MHD equilibrium calculations and is stable to both local and global MHD instabilities. The configuration has excellent confinement properties with small neoclassical transport and low bootstrap current (Ibootstrap ~ 2 kA). Calculations of collisional alpha particle confinement show small energy losses to the first wall (< 1.5%) and stable energetic particle/Alfven eigenmodes at high density. Low turbulent transport is produced using a combination of density profile control consistent with pellet fueling and reduced stiffness to turbulent transport via three-dimensional shaping. Transport simulations with the T3D-GX-SFINCS code suite with self-consistent turbulent and neoclassical transport predict that the Pfusion = 800 MW operating point is attainable with high fusion gain (Q = 40) at volume averaged electron densities of = 2 X 1020 m-3, below the Sudo density limit. Additional transport calculations show ignited solutions are available at slightly higher density (<n e = 2.2 X 10 20 m -3 ) with P fusion = 1.5 GW. The magnetic configuration is defined by a magnetic coil set with sufficient room for an island divertor, shielding and blanket solutions with tritium breeding ratios (TBR) above unity. An optimistic estimate for the gas-cooled solid breeder designed Helium Cooled Pebble Bed is TBR ~ 1.3. Infinity Two satisfies the physics requirements of a stellarator fusion pilot plant.https://cassyni-user-files-prod.s3.amazonaws.com/RoBPXhJJEMH8iW66odfKVG https://cassyni.com/slides/outline/9jLAXmRjWdqcdeobJj7uho https://cassyni.com/events/9jLAXmRjWdqcdeobJj7uho/abstract https://cassyni-user-files-prod.s3.amazonaws.com/UWkDHTMgeNKfuwDDc6ADUz https://cassyni.com/events/9jLAXmRjWdqcdeobJj7uho?videoPreview=1 Nonlinear evolution of Alfven waves and fast waves in magnetar magnetospheresnohttps://cassyni.com/events/9jLAXmRjWdqcdeobJj7uho?videoPreview=12024-10-17T15:00:00+00:002915.32Journal of Plasma PhysicsYoung and active neutron stars like magnetars may experience star quakes that can launch kHz Alfven waves into the magnetosphere. An Alfven wave packet propagating along the closed field lines undergoes several interesting nonlinear processes: (1) Alfven waves propagating to the outer magnetosphere may break and form an ejecta that accelerates away from the star. This process may be a viable mechanism to produce the simultaneous X-ray bursts and fast radio bursts from the galactic magnetar SGR 1935+2154. (2) The Alfven waves bouncing back and forth in the inner magnetosphere can convert to fast magnetosonic waves that spherically expands out. The fast waves can also become nonlinear before escaping the magnetosphere, producing shocks or regions with E>B that efficiently dissipate the fast wave energy, powering observable emission. In this talk, I’ll present our systematic study of all these processes and discuss their observational consequences.https://cassyni-user-files-prod.s3.amazonaws.com/UWkDHTMgeNKfuwDDc6ADUz https://cassyni.com/slides/outline/N5ZtoV7jtScCfojoZed5UZ https://cassyni.com/events/N5ZtoV7jtScCfojoZed5UZ/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Qihh1goVUQVtn5e7sWhLMU https://cassyni.com/events/N5ZtoV7jtScCfojoZed5UZ?videoPreview=1 Plasma Observatory ESA M7 candidate mission: science and numerical supportnohttps://cassyni.com/events/N5ZtoV7jtScCfojoZed5UZ?videoPreview=12023-07-06T15:00:00+00:003452.92Journal of Plasma PhysicsPlasma Observatory (PO) multi‐scale space mission is one of the five ESA M7 candidates for a launch in 2037 and is currently undergoing a competitive Phase 0 at ESA, for further downselection to Phase A at the end of 2023. The mission concept is tailored to study plasma energization and energy transport in the Earth's Magnetospheric System, simultaneously at both fluid and ion scales, at which the largest amount of electromagnetic energy is converted into energized particles and energy is transported. PO targets the two ESA Voyage 2050 themes for ESA-led M Mission: Magnetospheric Systems and Plasma Cross-scale Coupling. Baseline mission includes one mothercraft and six identical smallsat daughtercraft, covering all the key regions of the Magnetospheric System. Plasma energization and energy transport are central in space plasma physics research, with important implications for space weather science as well as for the understanding of distant astrophysical plasmas, and are strictly interconnected with important processes such as shocks, magnetic reconnection, turbulence and waves, plasma jets and their combination. The Earth's Magnetospheric System is the complex and highly dynamic plasma environment where the strongest particle energization and energy transport occur in the near‐Earth space. PO Numerical Simulation Working Group (NSWG) provides support to the development of the mission concept during all phases of mission design, not only from the scientific point of view but also for the definition of the payload, as well as for the optimization of the configuration of the spacecraft constellation. Here, we discuss the concept of the PO space mission and the role of the NSWG, focusing specifically on the complex interaction between shocks and plasma turbulence and presenting a novel combination of magnetohydrodynamic (MHD) and small‐scale, hybrid kinetic simulations, where a shock is propagating in a turbulent medium. Finally, we put our modelling effort in the context of spacecraft observations, elucidating the role of cross‐scale, multi‐spacecraft simultaneous measurements in resolving shock front irregularities at different scales.https://cassyni-user-files-prod.s3.amazonaws.com/Qihh1goVUQVtn5e7sWhLMU https://cassyni.com/slides/outline/QYov2uMN5jNh2kDN7LXiCV https://cassyni.com/events/QYov2uMN5jNh2kDN7LXiCV/abstract https://cassyni-user-files-prod.s3.amazonaws.com/PaGApctSFnnH75Q6GoKPWe https://cassyni.com/events/QYov2uMN5jNh2kDN7LXiCV?videoPreview=1 Accelerating the rate of discovery: Toward high-repetition-rate laser experiments for High-Energy Density (HED) Science and Inertial Fusion Energy (IFE)nohttps://cassyni.com/events/QYov2uMN5jNh2kDN7LXiCV?videoPreview=12022-11-17T16:00:00+00:002835.32Journal of Plasma PhysicsAs high-intensity short-pulse lasers that can operate at high-repetition-rate (HRR) (>10 Hz) come online around the world, the high-energy-density (HED) science they enable will experience a radical paradigm shift. The >10^3 increase in shot rate over today’s shot-per-hour drivers translates into dramatically faster data acquisition and more experiments, and thus the potential to significantly accelerate the advancement of HED science. However, to fully realize the potential benefits of HRR facilities requires a fundamental shift in how they are operated, and in fact, how the experiments done on them are designed and executed. Current energetic driver facilities depend on the ability to manually tune the lasers, the targets, the diagnostics settings, and more, between single shots or sets of shots through a manual feedback loop of data collection, data analysis, and optimization largely driven by experience and intuition. At 10 Hz, this paradigm is no longer sustainable as more complex data is collected more quickly than is possible to analyze manually. Simultaneously, on-the-fly optimization of experiments will become ever more crucial as higher repetition rates will lead to more deliberate inter-shot variations and the improved operational range to allow exploration over larger regions of phase space. Consequently, it is likely that the next generation of laser facilities will be limited not by their hardware but by our ability to use it effectively. We will present the vision and ongoing work to realize a HRR framework for rapidly delivered optimal experiments coupled to cognitive simulation to provide new insights in HED science, and lay the groundwork for Inertial Fusion Energy (IFE) rep rate operations.https://cassyni-user-files-prod.s3.amazonaws.com/PaGApctSFnnH75Q6GoKPWe https://cassyni.com/slides/outline/H95rLeeVVs5BGi2TZAv5kR https://cassyni.com/events/H95rLeeVVs5BGi2TZAv5kR/abstract https://cassyni-user-files-prod.s3.amazonaws.com/J98XK6mfRkhFPRv5azDKoU https://cassyni.com/events/H95rLeeVVs5BGi2TZAv5kR?videoPreview=1 Status of the Divertor Tokamak Test facilitynohttps://cassyni.com/events/H95rLeeVVs5BGi2TZAv5kR?videoPreview=12022-06-23T15:00:00+00:003497.6Journal of Plasma PhysicsThis talk illustrate the physics basis which supports the main engineering choices in the Divertor Test Tokamak facility (DTT) under construction in Frascati, Italy. DTT is a superconducting tokamak with 6 T on-axis maximum toroidal magnetic field, carrying plasma current up to 5.5 MA in pulses with total length up to 100 s. The D-shaped device has a major radius R=2.19 m, minor radius a=0.70 m, with an average triangularity 0.3. The auxiliary heating power coupled to the plasma at maximum performance is 45 MW, which allows matching the PSEP/R values with those of ITER and DEMO, where PSEP is the power flowing through the last closed magnetic surface. The primary mission of DTT is the study of the plasma exhaust and of tokamak divertor performance in conditions relevant to ITER and DEMO and in regimes where plasma core and edge behaviors are integrated. In addition to that DTT will provide a facility for high performance tokamak physics and to address core confinement and stability issues in a variety of plasma configurations, including negative triangularity scenarios and the management of transient events like disruptions and ELMs.https://cassyni-user-files-prod.s3.amazonaws.com/J98XK6mfRkhFPRv5azDKoU https://cassyni.com/events/KcKsa4t7h9qfdeW26rpiUM/abstract https://cassyni-user-files-prod.s3.amazonaws.com/LcNYYX1Hd3TjkNPe8g7xXQ https://cassyni.com/slides/outline/XxXyjA4EfbgXXKjq5DPScV https://cassyni.com/events/XxXyjA4EfbgXXKjq5DPScV/abstract https://cassyni-user-files-prod.s3.amazonaws.com/FJ6T3F8eUQL1tCnkn4ANpE https://cassyni.com/events/XxXyjA4EfbgXXKjq5DPScV?videoPreview=1 Extreme Plasma Astrophysics: a Shining New Frontiernohttps://cassyni.com/events/XxXyjA4EfbgXXKjq5DPScV?videoPreview=12021-09-16T15:00:00+00:003704.8Journal of Plasma PhysicsWhile traditional plasma physics deals with plasmas made up of a fixed number of electrons and ions that are nonrelativistic and nonradiative, there exist in the Universe important plasma environments with physical conditions so extreme that additional “exotic physics” (from a plasma physicist’s point of view) processes come into play: special and general relativity, strong coupling between plasma particles and photons, and, in most extreme cases, QED effects like pair production and annihilation. These processes alter the plasma dynamics near compact relativistic astrophysical objects — neutron stars and black holes — arguably, the most enigmatic and fascinating objects in the Universe. Understanding how collective plasma processes (waves, instabilities, shocks, magnetic reconnection, turbulence, etc.) operate under these exotic conditions calls for the development of a new, richer physical framework, which forms the scope of Extreme Plasma Astrophysics. I will review the rapid progress that is being made now in exploring this exciting new frontier, stimulated by the exploding astrophysical motivation and enabled by concerted, vigorous theoretical efforts and recent computational breakthroughs such as the advent of novel relativistic kinetic plasma codes incorporating radiation reaction and pair creation. I will illustrate this progress with recent studies of radiative relativistic turbulence and magnetic reconnection with pair creation in the context of accreting black-hole coronae and neutron-star magnetospheres. I will end by outlining the future directions of the burgeoning field of Extreme Plasma Astrophysics.https://cassyni-user-files-prod.s3.amazonaws.com/FJ6T3F8eUQL1tCnkn4ANpE https://cassyni.com/slides/outline/SXQLDdwTqZbT8TVbUJPed3 https://cassyni.com/events/SXQLDdwTqZbT8TVbUJPed3/abstract https://cassyni-user-files-prod.s3.amazonaws.com/79QDNudF8tY2rgP9eLxUNi https://cassyni.com/events/SXQLDdwTqZbT8TVbUJPed3?videoPreview=1 Exploring edge turbulence in the low and improved confinement regimes at the ASDEX Upgrade tokamaknohttps://cassyni.com/events/SXQLDdwTqZbT8TVbUJPed3?videoPreview=12022-03-03T16:00:00+00:002749.64Journal of Plasma PhysicsFuture tokamak fusion reactors will need to operate in a regime of high energy confinement while particle confinement remains low enough that impurities can be exhausted. The low confinement operating regime L-mode has no edge transport barrier and lacks high energy confinement. The high confinement operating regime H-mode has been a target for high confinement operation, however its steep pedestal gradients lead to the edge instability Edge Localized Modes (ELMs). ELMs exhaust impurities and allow for steady-state high confinement operation, but they also release substantial energy which can damage material surfaces. The “improved” confinement regime I-mode is a promising operational scenario for future fusion reactors because it features an edge energy transport barrier without a particle transport barrier and it is naturally ELM-free. The mechanism that leads to this separation of transport channels in I-mode is an open question. The nature of the edge and pedestal turbulence in I-mode plasmas, and its role in determining transport, is still under investigation. In this work we explore edge fluctuations in the L-mode and I-mode edge at the ASDEX Upgrade tokamak through detailed study with turbulence diagnostics. In conjunction, linear gyrokinetic studies probe the nature of the turbulence from the outer core to the pedestal top. We find that the pedestal Weakly Coherent Mode (WCM) remains similar in nature in L-mode and I-mode and that ion-scale fluctuations in the outer core and pedestal top also undergo little change between L-mode and I-mode. The electron scale is a potential candidate for the suppression of heat flux in I-mode, separated from possible particle flux mechanisms. Cross-scale coupling is seen to be important in the I-mode outer core and pedestal.https://cassyni-user-files-prod.s3.amazonaws.com/79QDNudF8tY2rgP9eLxUNi https://cassyni.com/events/T23wGKazH29W8E2V4jgStM/abstract https://cassyni.com/events/5nAxGvmRQLLBzU3KCBUJjX/abstract https://cassyni.com/slides/outline/CBY9XtbZoaLGE2BcTdvbkq https://cassyni.com/events/CBY9XtbZoaLGE2BcTdvbkq/abstract https://cassyni-user-files-prod.s3.amazonaws.com/45mRXH1TxJfUUwyCTWDmpS https://cassyni.com/events/CBY9XtbZoaLGE2BcTdvbkq?videoPreview=1 Efficacy of Image-Guided Epidural Steroid Injections in Pediatric Patientsnohttps://cassyni.com/events/CBY9XtbZoaLGE2BcTdvbkq?videoPreview=12025-10-14T09:48:56+00:00678.16Society for Pediatric Interventional Radiology## Introduction Epidural steroid injection (ESI) is an established treatment for spinal radiculopathy and back pain, however there is limited data on efficacy in children. The purpose of this study is to evaluate pediatric ESI responses, the recurrence rate, and potential factors influencing these outcomes. ## Materials and Methods A 7-year retrospective single-center review of children receiving image-guided ESI was performed. Non-verbal patients were excluded. Pre- and post-procedure symptoms were rated on a 0-10 scale. Responses were recorded from chart reviews as unchanged, partial response, significant response, or resolved. Recurrence was defined as returning/worsening symptoms after 1 month. Trauma history, limitations in daily activities (ADLs), sports participation, MRI findings, corticosteroid selection, and medical therapies were included for multivariate analysis. Ordinal logistic and binary probit regression were to determine the respective effects of confounding factors on outcomes. ## Results 45 children remained after exclusions with a mean age of 16.9 +/- 1.9 years. Symptom improvement occurred in 36 patients (80%) with significant improvement or resolution in 24 patients (53%) and a median numerical scale improvement of 60% [IQR 23%, 97%]. Oral steroid use (p=0.03), non-steroidal anti-inflammatory (NSAID) use (p=0.01), limitations in ADLs (p=0.04), and trauma (p=0.047) correlated with post-procedure improvement. Recurrence occurred in 26 cases (58%) increasing with slightly younger age (p=0.045) and NSAID use (0.02), although 87% of patients used NSAIDs. ## Discussion Epidural steroid injections provided relief in most symptomatic children, however recurrence occurred in over half the patients. Oral medication use, limitations in ADLs, and trauma history correlated with improved responses.https://cassyni-user-files-prod.s3.amazonaws.com/45mRXH1TxJfUUwyCTWDmpS https://cassyni.com/slides/outline/L6UGZRFgt7ijMG28PH11w3 https://cassyni.com/events/L6UGZRFgt7ijMG28PH11w3/abstract https://cassyni-user-files-prod.s3.amazonaws.com/UoYSG9t4GnCY9uDH9EjsdG https://cassyni.com/events/L6UGZRFgt7ijMG28PH11w3?videoPreview=1 Quasicentral modulus as a noncommutative nonlinear condenser capacitynohttps://cassyni.com/events/L6UGZRFgt7ijMG28PH11w3?videoPreview=12022-05-05T18:00:00+00:003241.76Acta Scientiarum MathematicarumThe quasicentral modulus is key in many questions about normed ideal perturbations of n-tuples of operators. I have extended the definition to that of a condenser quasicentral modulus and I will point out a noncommutative analogy with condenser capacity in nonlinear potential theory.https://cassyni-user-files-prod.s3.amazonaws.com/UoYSG9t4GnCY9uDH9EjsdG https://cassyni.com/events/WxjZaTVEYBuCsXr9zpEhss/seminar/qa https://cassyni.com/slides/outline/WxjZaTVEYBuCsXr9zpEhss https://cassyni.com/events/WxjZaTVEYBuCsXr9zpEhss/abstract https://cassyni-user-files-prod.s3.amazonaws.com/97tWoAgFQFJXzGwAeFdCYn https://cassyni.com/slides/outline/8jZNVhNcnayk522z2HZEv9 https://cassyni.com/events/8jZNVhNcnayk522z2HZEv9/abstract https://cassyni-user-files-prod.s3.amazonaws.com/CZqfijPK1sj1GnpZa3NqwU https://cassyni.com/events/8jZNVhNcnayk522z2HZEv9?videoPreview=1 Scattering light through temporal structurenohttps://cassyni.com/events/8jZNVhNcnayk522z2HZEv9?videoPreview=12023-02-07T14:00:00+00:004292.44MetaMATA sufficiently fast temporal drive can induce a host of peculiar temporal scattering phenomena, such as the temporal analogues of spatial reflection and diffraction, but obeying different causal relations. In this talk I will present a number of theoretical advances and new ideas in this direction, as well as two series of recent experiments that are pioneering the growing field of temporal electromagnetic control. Firstly, I will demonstrate the first realization of electromagnetic time-diffraction, the temporal analogue of Young's famous double-slit experiment, performed in Indium Tin Oxide at near-optical frequencies, and discuss its implications for the microscopic study of non-equilibrium dynamics in transparent conducting oxides, as well as its potential applications for temporal light modulation and for the direct measurement of the temporal coherence of optical pulses. In the second part of the talk I will demonstrate the first observation of electromagnetic time-reflection, performed in a microwave waveguide, explaining why this phenomenon can be practically observed despite the recent claims of its unfeasibility, and I will show how this platform can be leveraged to achieve temporal coherent wave control, whereby a broadband pulse can be "instantaneously" erased or "sculpted" by means of an additional idler pulse, tailored to annihilate the first entirely or in part upon time-reflection.https://cassyni-user-files-prod.s3.amazonaws.com/CZqfijPK1sj1GnpZa3NqwU https://cassyni.com/slides/outline/DBnXWfQkNkw7uSN1ydBbrD https://cassyni.com/events/DBnXWfQkNkw7uSN1ydBbrD/abstract https://cassyni-user-files-prod.s3.amazonaws.com/N2myEo4yDGXELw4H9CAver https://cassyni.com/events/DBnXWfQkNkw7uSN1ydBbrD?videoPreview=1 Wastewater-based epidemiology for COVID and beyondnohttps://cassyni.com/events/DBnXWfQkNkw7uSN1ydBbrD?videoPreview=12022-09-21T13:00:00+00:003594.04Nature WaterWastewater surveillance has proven to be an effective approach to monitor the spread of COVID-19 in the last two years. The specialists have learnt a great deal about the potential of wastewater-based epidemiology, but there are still challenges of technical and legal nature to apply this technique more broadly. We’ll discuss the future of wastewater-based epidemiology with Andrew Singer (UK Centre for Ecology & Hydrology, United Kingdom), Manish Kumar (University of Petroleum and Energy Studies, India), Mariana Matus (Biobot Analytics, USA) and Amy Kirby (Centers for Disease Control and Prevention).https://cassyni-user-files-prod.s3.amazonaws.com/N2myEo4yDGXELw4H9CAver https://cassyni.com/slides/outline/HdCdDNWBHU2UAd5wdvGDJD https://cassyni.com/events/HdCdDNWBHU2UAd5wdvGDJD/abstract https://cassyni-user-files-prod.s3.amazonaws.com/9uk5F1PEV22qsLSTaXSTaN https://cassyni.com/events/HdCdDNWBHU2UAd5wdvGDJD?videoPreview=1 An Efficient Implicit Solver for Incompressible flownohttps://cassyni.com/events/HdCdDNWBHU2UAd5wdvGDJD?videoPreview=12022-09-14T15:30:00+00:001425.8NEKTAR++Under-resolved Direct Numerical Simulation (uDNS) offers highly resolved insight into complex and unsteady flow phenomena such as vortices. The numerical algorihtms of uDNS however are difficult to stabilise whilst maintaining a high computational efficiency. In particular for industrial applications, complex geometries provide challenging test cases for a uDNS solver and significantly decrease the overall efficiency through numerical instabilities. Implicit time- stepping increases the stability of the algorithm, however, at larger computational costs. This work explores the potential of implicit time-stepping using Velocity-Correction schemes. While the cost for each time step increase, implicit schemes lift the CFL restriction for the time step and allow balancing temporal and spatial discretisation errors to achieve an efficient solution. At this stage of the project, a linearly implicit Velocity-Correction scheme based on Dong and Shen (2010) is presented and its stability margin compared to the widely used Semi-Implicit Velocity-Correction scheme.https://cassyni-user-files-prod.s3.amazonaws.com/9uk5F1PEV22qsLSTaXSTaN https://cassyni.com/slides/outline/VyQjNTgJFusL4JKkcGpwSM https://cassyni.com/events/VyQjNTgJFusL4JKkcGpwSM/abstract https://cassyni-user-files-prod.s3.amazonaws.com/EbvtMYnAtSFSmkhFc9NYcn https://cassyni.com/events/VyQjNTgJFusL4JKkcGpwSM?videoPreview=1 Strong and Weak Solutions of a Stochastic General Linear-Quadratic Diffusion Modelnohttps://cassyni.com/events/VyQjNTgJFusL4JKkcGpwSM?videoPreview=12022-12-01T22:00:00+00:003355.32SACLThis paper is concerned with a one-dimensional general linear-quadratic diffusion model (LQD model) consisting of a linear drift term and a quadratic diffusion term. A strong solution is found, conditioned on two dependent Wiener processes, using the fundamental solution proposed by Shaw and Schofield (2015, p. 982) where the LQD is decomposed into the sum of two underlying dependent processes: a gBm and an aBm. The strong solution embodies the sum of (i) a gBm, (ii) a time-integral of a gBm, and (iii) a standard Wiener process. An approximative weak solution is inspired by Ioffe and Nishnianidze (2020). Three distinctive cases of the LQD model are expressed as canonical equations with a unity diffusion function. Subsequently, they are turned into corresponding Schrödinger diffusion equations. A set of intertwining relationships produces accurate approximations related to the heat equation. Known solutions for each case are then transformed back into probability density functions in the original state-variable. The result constitutes the product of three case-specific components: (i) a stationary solution associated with one of the three fundamental Pearson distributions, (ii) a time-dependent density numerically approximated by an orthogonal polynomial series expansion (Legendre, Laguerre, or Hermite), and (iii) a time-dependent log-normal distribution function. Keywords: linear-quadratic stochastic model, Fokker–Planck equation, Lamperti transform, Schrödinger diffusion equation, heat equation, supersymmetry intertwining operators, Pearson family of probability distributions, classical orthogonal polynomial series expansion. Presentation [here](https://web.tresorit.com/l/noonE#BdHMXaDmOQRltEPGhhSA-g) Paper [here](https://web.tresorit.com/l/3gKiV#mhSpRlwf_UJSmHRwoqLnyw) https://cassyni-user-files-prod.s3.amazonaws.com/EbvtMYnAtSFSmkhFc9NYcn https://cassyni.com/slides/outline/YSekbsuvTCdpREoK9xjaAH https://cassyni.com/events/YSekbsuvTCdpREoK9xjaAH/abstract https://cassyni-user-files-prod.s3.amazonaws.com/UrHXWQJkrMS5HS7p6pXJyC https://cassyni.com/events/YSekbsuvTCdpREoK9xjaAH?videoPreview=1 Bayesian optimization and design of experimentsnohttps://cassyni.com/events/YSekbsuvTCdpREoK9xjaAH?videoPreview=12022-10-19T13:00:00+00:003315.92Department of Chemical EngineeringBayesian optimization is a popular machine learning-based approach for optimizing black-box functions, with successful applications including hyperparameter tuning of machine learning algorithms, design of engineering systems, and sensor set selection. After introducing Bayesian optimization, we present some joint research with the BASF Data Science for Materials & Chemistry teams. With BASF, we’re interested to solve Bayesian optimization challenges which may simultaneously exhibit: multiple objectives, mixed-feature spaces, asynchronous decisions, large batch sizes, input constraints, multi-fidelity observations, hierarchical choices, and costs associated with switching between experimental points. We review the machine learning contributions that we’ve found useful towards achieving these goals and discuss our own methodological and software contributions. We review work from many groups. My own work is a collaboration between Imperial (Jose Pablo Folch, Alexander Thebelt, Shiqiang Zhang, Jan Kronqvist, Calvin Tsay, Ruth Misener) and BASF (Robert Lee, Behrang Shafei, Nathan Sudermann-Merx, David Walz). https://cassyni-user-files-prod.s3.amazonaws.com/UrHXWQJkrMS5HS7p6pXJyC https://cassyni.com/slides/outline/8Et9LPDCwmVvFZ3UEBSGjw https://cassyni.com/events/8Et9LPDCwmVvFZ3UEBSGjw/abstract https://cassyni-user-files-prod.s3.amazonaws.com/4y9ich2xaGfjRaLTDb76Fp https://cassyni.com/events/8Et9LPDCwmVvFZ3UEBSGjw?videoPreview=1 Celebrating Editorial Impactnohttps://cassyni.com/events/8Et9LPDCwmVvFZ3UEBSGjw?videoPreview=12022-12-13T16:30:00+00:003410.32Topics at the heart of our communityJoin us to celebrate your fellow Editors and learn about the editorial initiatives that have made an impact on their journals. From Editorial Board development to support growth and increase diversity, to the impact of new collections, there’s a lot to celebrate in this December's special edition of the Spotlight On webinar series.https://cassyni-user-files-prod.s3.amazonaws.com/4y9ich2xaGfjRaLTDb76Fp https://cassyni.com/events/5H5PQAsiX6xTyqbn7ZGi61/abstract https://cassyni-user-files-prod.s3.amazonaws.com/D8pnrKd1XjMSotMtiX8dAn https://cassyni.com/events/H8fWdCvCTTBH5rAHEVSnWH/seminar/qa https://cassyni.com/slides/outline/H8fWdCvCTTBH5rAHEVSnWH https://cassyni.com/events/H8fWdCvCTTBH5rAHEVSnWH/abstract https://cassyni-user-files-prod.s3.amazonaws.com/EdUBDSAYZbfi5bJYGYGV4S https://cassyni.com/events/H8fWdCvCTTBH5rAHEVSnWH?videoPreview=1 Atomization in Forensic Applications and Aerosolization in Dentistrynohttps://cassyni.com/events/H8fWdCvCTTBH5rAHEVSnWH?videoPreview=12023-09-12T14:00:00+00:002876.36Experiments in FluidsThe talk discusses two inter-connected atomization and aerosolization-related situations. Keywords: (1) Biomedical, biological and bio-mimetic, (2) Miscellaneous 1. The first one arises in relation to the blood pattern analysis (BPA) in forensic applications, where a pattern of blood stains on the crime scene is used to determine the origin of blood spatter. Here, it is shown that blood drops resulting from gunshots form due to the Rayleigh-Taylor instability, which occurs in backward spatter because the denser blood is accelerated toward air. The subsequent evolution of backward spatter is treated as a system of two-interpenetrating continua, with a blob of blood droplets propagating through air experiencing gravity force, as well as aerodynamic drag, producing viscous suction and causing air entrainment. The leading blood drops experience the highest drag and entrain air in their wake, which results in the collective effect reducing the air drag experienced by the subsequent drops. The secondary, aerodynamically-driven atomization also pays significant role. The results also reveal a significant interaction of the backward blood spatter with the oncoming self-similar turbulent vortex ring of propellant muzzle gases in short-range shootings. It is shown that there is even possibility that a blood drop from the backspatter will fully turn around by a powerful vortex ring and land behind a victim, which is confirmed experimentally. 2. The second situation arises in dentistry where cavitron scalers severely aerosolize the irrigation water in contact with a tooth and a scaler vibrating at the frequency of 30 kH. Formation of droplets in this case is caused by the Faraday instability and is responsible for aerosol transmissibility of SARS-CoV-2 and other viruses and bacteria, which become airborne. The present work explored this situation experimentally and theoretically and introduced a novel approach, which remediated this dangerous situation and already found practical applications in dentistry. By altering the physical response of water to the ultrasonic forces by miniscule concentrations of FDA-approved polymers and thus, introducing viscoelasticity, the generation of aerosol droplets and the distance any aerosol may spread beyond the point of generation can be markedly suppressed or completely eliminated, which made dental procedures safe again. https://cassyni-user-files-prod.s3.amazonaws.com/EdUBDSAYZbfi5bJYGYGV4S https://cassyni.com/slides/outline/2okVps6S7jQqrgoEdGSUkV https://cassyni.com/events/2okVps6S7jQqrgoEdGSUkV/abstract https://cassyni-user-files-prod.s3.amazonaws.com/TtVf3WQNeb37S7vNvNPzJa https://cassyni.com/events/2okVps6S7jQqrgoEdGSUkV?videoPreview=1 Very-large scale motions in the atmospheric surface layernohttps://cassyni.com/events/2okVps6S7jQqrgoEdGSUkV?videoPreview=12021-06-18T15:00:00+00:001479.72Journal of Fluid MechanicsVery-large scale motions (VLSMs) are typical structures in wall-bounded turbulence at high Reynolds number, which make important contributions to mass and energy transport. This talk will present the atmospheric surface layer observations carried out at the Qingtu Lake observation array (QLOA) site. Furthermore, some studies on the VLSMs in the atmospheric surface layer based on the observed data are introduced, including the morphological and dynamic characteristics of the VLSMs and its effect on the sand dust transportation. The influences of dust particles and heat flux on the VLSMs are discussed as well. It is found that the length scale of the VLSMs has Reynolds number invariance, and evidenced that the VLSMs in the atmospheric surface layer evolute with a top-down mechanism. In the sand-laden flow, the energy of the VLSMs increases, while their energy fraction decreases. The inclination angle of the VLSMs increases with the increase of dust concentration. It is revealed that the VLSMs dominates the streamwise transport of PM10 (tiny particles with size less than 10 μm), but suppress the vertical transport of PM10 near the surface. Finally, it is demonstrated that the temperature and PM10 in the atmospheric surface layer have large structural feature similar as the VLSMs, though the shape of temperature and PM10 structures are different with the VLSMs.https://cassyni-user-files-prod.s3.amazonaws.com/TtVf3WQNeb37S7vNvNPzJa https://cassyni.com/slides/outline/3JQ6sYjxZBxtrTL8DhjH1o https://cassyni.com/events/3JQ6sYjxZBxtrTL8DhjH1o/abstract https://cassyni-user-files-prod.s3.amazonaws.com/NTN1XzHbpYwfdVaMzeGN4v https://cassyni.com/events/3JQ6sYjxZBxtrTL8DhjH1o?videoPreview=1 Infection transmission in the built environment – the interface of biology, fluid dynamics, design and human behaviournohttps://cassyni.com/events/3JQ6sYjxZBxtrTL8DhjH1o?videoPreview=12021-02-12T16:00:00+00:003659.24Journal of Fluid MechanicsCOVID-19 has presented us with the most difficult healthcare and societal challenge we have faced in living memory. To understand the mechanisms of transmission we have had to rapidly collect new evidence on the SARS-CoV-2 virus ranging from laboratory data on survival and fluid dynamics studies on droplet dispersion through to epidemiological evidence from outbreaks, contract tracing and cohort studies. Over this time we have become acutely aware of the role that the environment plays in transmission, and how our interactions in indoor spaces determine the risk of infection. But this is not the first disease to be associated with the built environment. Many other respiratory diseases have a clear association with indoor spaces including tuberculosis and influenza. Pathogens such as pseudomonas, legionella are associated with water systems, and even hospital acquired infections such as MRSA have been linked to dispersion within the environment. This presentation sets out what we know about transmission of pathogens in the built environment particular focus on the complex interactions between engineering systems, fluid dynamics, microbiology and the behaviour of people that determine the dispersion, transport and survival of pathogens. Engineering and modelling approaches that can be used to understand mechanisms for transmission and implement mitigation strategies are discussed. The talk discusses how research findings may be used to support practice, and where there gaps in knowledge in both understanding of fundamental processes and the real performance of engineering solutions.https://cassyni-user-files-prod.s3.amazonaws.com/NTN1XzHbpYwfdVaMzeGN4v https://cassyni.com/slides/outline/Dg1nquKymobKNxdGEogAhK https://cassyni.com/events/Dg1nquKymobKNxdGEogAhK/abstract https://cassyni-user-files-prod.s3.amazonaws.com/2urayhdJAmQSjiAYHhrN6a https://cassyni.com/events/Dg1nquKymobKNxdGEogAhK?videoPreview=1 From Topology to Devicesnohttps://cassyni.com/events/Dg1nquKymobKNxdGEogAhK?videoPreview=12022-07-05T06:00:00+00:001863.04ETOPIMThe thrive towards the implementation of topological band structures in metamaterials has led to the discovery of a number of new physical phenomena in the realm classical waves. To implement the sought-after models with a specific behavior, new toolboxes had to be established. These new techniques now allow us to build devices with high-level functionalities such as voice recognition-based classifiers.https://cassyni-user-files-prod.s3.amazonaws.com/2urayhdJAmQSjiAYHhrN6a https://cassyni.com/slides/outline/ADUZX7oJhbigMGKhb9JDAV https://cassyni.com/events/ADUZX7oJhbigMGKhb9JDAV/abstract https://cassyni-user-files-prod.s3.amazonaws.com/6jt25ztca4hChNCfEd1SpN https://cassyni.com/events/ADUZX7oJhbigMGKhb9JDAV?videoPreview=1 Converting between circularly polarized waves and longitudinal fields with an individual plasmonic nanohelixnohttps://cassyni.com/events/ADUZX7oJhbigMGKhb9JDAV?videoPreview=12022-07-07T07:20:00+00:001060.04ETOPIMA wide variety of optical applications and techniques require control of light polarization. So far, the manipulation of light polarization relies on components capable of interchanging two polarization states of the transverse field of a propagating wave (e.g., linear to circular polarizations, and vice versa). Here, we demonstrate that an individual helical nanoantenna is capable of locally converting longitudinally-polarized confined near-fields into a circularly polarized freely propagating wave, and vice versa, over a broad spectral range.https://cassyni-user-files-prod.s3.amazonaws.com/6jt25ztca4hChNCfEd1SpN https://cassyni.com/slides/outline/CgiakY2vttVAiCoG8qCqtR https://cassyni.com/events/CgiakY2vttVAiCoG8qCqtR/abstract https://cassyni-user-files-prod.s3.amazonaws.com/2XnJny53P6Y7PMFbMUZCVC https://cassyni.com/slides/outline/M5mUenYjm2pt21r8VFULjw https://cassyni.com/events/M5mUenYjm2pt21r8VFULjw/abstract https://cassyni-user-files-prod.s3.amazonaws.com/NfhnyK9ZptKppDuaJ99R8A https://cassyni.com/events/M5mUenYjm2pt21r8VFULjw?videoPreview=1 Research activities at NASA: the HERA Astronaut Analog mission, Astrobee, and the Advanced Composite Solar Sail Systemnohttps://cassyni.com/events/M5mUenYjm2pt21r8VFULjw?videoPreview=12022-12-14T15:00:00+00:003425.92Department of AeronauticsDuring this seminar, I will talk about three of the projects I’ve been involved with at NASA in the last few years: 1. **The Human Exploration Research Analog (HERA)** is a ground-based astronaut analog mission run at NASA’s JSC in Houston to study and evaluate impacts on the crew due to isolation, remoteness, and confined habitation. NASA scientists use the collected data to develop and verify countermeasures to reduce or mitigate psychological and physiological effects for future Deep Space missions. This simulation was a 45-day trip to Mars’s moon Phobos and back with the goal of performing geological operations with complete communications delays in effect. 2. **Astrobee** is a new class of free-flying robots that operates in the interior of the International Space Station (ISS). In addition to being a research platform for microgravity free-flying robotics, Astrobee improves the efficiency of ISS operations by providing flight and payload controllers with a mobile camera and a sensor platform. 3. NASA is developing new deployable structures and material technologies for solar sail propulsion systems destined for future low-cost deep space missions. NASA’s Advanced Composite Solar Sail System (ACS3) uses composite materials in its novel, lightweight booms that deploy from a Cubesat. Data obtained from ACS3 will guide the design of future larger-scale composite solar sail systems that could be used for several deep space exploration missions.https://cassyni-user-files-prod.s3.amazonaws.com/NfhnyK9ZptKppDuaJ99R8A https://cassyni.com/slides/outline/PZ1VtCnMxKbNNxKh2wNyTs https://cassyni.com/events/PZ1VtCnMxKbNNxKh2wNyTs/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Pp9RQsKJ2ZTwED8vPsWp4n https://cassyni.com/events/PZ1VtCnMxKbNNxKh2wNyTs?videoPreview=1 Dripping down the rivuletnohttps://cassyni.com/events/PZ1VtCnMxKbNNxKh2wNyTs?videoPreview=12020-10-09T15:00:00+00:003896.32Journal of Fluid MechanicsWe revisit the canonical Rayleigh-Taylor instability and investigate the case of a thin film of liquid continuously flowing down the underside of an inclined plane. The presence of a natural flow along the plane competes with the conventional droplet forming instability and gives rise to an intricate pattern formation, which is studied experimentally, numerically and theoretically using the lubrication equation. We observe the prevalence of streamwise-invariant structures, modulated along the transverse direction perpendicular to the flow direction, called rivulets. We determine the universal thickness profile towards which they saturate and explore the origin of this pattern selection by analyzing the impulse response as well as the response to localized defect on the substrate. We eventually discuss the role of these hydrodynamic instabilities on the morphogenesis of some typical karst draperies structures encountered in limestone caves.https://cassyni-user-files-prod.s3.amazonaws.com/Pp9RQsKJ2ZTwED8vPsWp4n https://cassyni.com/slides/outline/WU5xXmqi6jM9smKGQNwucZ https://cassyni.com/events/WU5xXmqi6jM9smKGQNwucZ/abstract https://cassyni-user-files-prod.s3.amazonaws.com/E8YCkwYbPKq8mVnbcnete https://cassyni.com/events/WU5xXmqi6jM9smKGQNwucZ?videoPreview=1 Future wearables by soft electronic materialsnohttps://cassyni.com/events/WU5xXmqi6jM9smKGQNwucZ?videoPreview=12022-12-21T05:00:00+00:002424.96Mechanical EngineeringWearable devices enable long-term and precise healthcare monitoring without medical professionals, which is especially important in a pandemic or aging society. As the next-generation of current wearable devices in the form of a watch or ring, wearable devices with skin-like softness and stretchability have been developed for improved comfort of wear and signal integrity. In this talk, we introduce several soft electronic materials by fully utilizing a variety of soft nanomaterials (e.g., silver nanowires, carbon nanotubes, polymer semiconductors, liquid metals) to realize soft electronic devices. Examples include wireless stretchable sensors to form body-area sensor networks, and stretchable high-frequency diodes to enable wireless operation of sensor and display. Furthermore, we discuss the application of skin-like soft electronic devices in human-computer interfaces for seamless communications between robots and humans.https://cassyni-user-files-prod.s3.amazonaws.com/E8YCkwYbPKq8mVnbcnete https://cassyni.com/slides/outline/RXbv4wNTi9p8UfbvPuEutR https://cassyni.com/events/RXbv4wNTi9p8UfbvPuEutR/abstract https://cassyni-user-files-prod.s3.amazonaws.com/6yZSJdex4khvZ26QwGYsu8 https://cassyni.com/events/RXbv4wNTi9p8UfbvPuEutR?videoPreview=1 Analysis and Application of Advanced Algorithm for Aeronautical Flowsnohttps://cassyni.com/events/RXbv4wNTi9p8UfbvPuEutR?videoPreview=12020-01-31T13:00:00+00:003032.48UK Fluids NetworkAdvanced high order methods using Spectral/hp element discretization including Galerkin, Discontinuous Galerkin (DG) and Flux Reconstruction (FR) formulations are gaining notable interest in both the academic and industrial sectors. The compact nature of the approach is not only attractive from the perspective of implementation on modern computational hardware but also provides a consistent geometric and spatially localized accuracy unlike many high order finite volume methods. These features make the methodology attractive in complex geometry flows involving transitional and turbulent boundary layers demanding a high level of accuracy for high end engineering applications that commonly arise in the aeronautical sector. In this presentation, we will present our current work on developing a spectral/hp element implicit compressible flow solver for aeronautically related application. The demands of handling “industrial strength” complex geometries at high Reynolds numbers necessarily leads to severe time step restrictions when using explicit time stepping approaches. We have therefore developed a Jacobian-Free-Newton-Krylov (JFNK) implicit solver which makes use of the explicit technique but still require the suitable preconditioners that can be demanding from a memory footprint perspective. After motivating the need for this type of solver we will outline the implementation challenges behind the scheme and demonstrate the suitability of the approach for a number of representative examples.https://cassyni-user-files-prod.s3.amazonaws.com/6yZSJdex4khvZ26QwGYsu8 https://cassyni.com/slides/outline/6GKMGH8zbJDFi5ZRUbecCD https://cassyni.com/events/6GKMGH8zbJDFi5ZRUbecCD/abstract https://cassyni-user-files-prod.s3.amazonaws.com/URoeBcx3cPSV5Cqha5TiXY https://cassyni.com/events/6GKMGH8zbJDFi5ZRUbecCD?videoPreview=1 Nonlinear Independent Component Analysis: Identifiability, Self-Supervised Learning, and Likelihoodnohttps://cassyni.com/events/6GKMGH8zbJDFi5ZRUbecCD?videoPreview=12021-04-29T16:00:00+00:003156.04DataSıgUnsupervised learning, in particular learning general nonlinear representations, is one of the deepest problems in machine learning. Estimating latent quantities in a generative model provides a principled framework, and has been successfully used in the linear case, especially in the form of independent component analysis (ICA). However, extending ICA to the nonlinear case has proven to be extremely difficult: A straight-forward extension is unidentifiable, ie it is not possible to recover those latent components that actually generated the data. Recently, we have shown that this problem can be solved by using additional information, in particular in the form of temporal structure or some additional observed variable. Our methods were originally based on 'self-supervised' learning increasingly used in deep learning, but in more recent work, we have provided likelihood-based approaches. In particular, we have developed computational methods for efficient maximization of the likelihood for two variants of the model, based on variational inference or Riemannian relative gradients, respectively.https://cassyni-user-files-prod.s3.amazonaws.com/URoeBcx3cPSV5Cqha5TiXY https://cassyni.com/slides/outline/KqJoSfkCigEJyr5U7wcU5 https://cassyni.com/events/KqJoSfkCigEJyr5U7wcU5/abstract https://cassyni-user-files-prod.s3.amazonaws.com/64R5wGdLWrjKU1LNYi8Rsc https://cassyni.com/events/KqJoSfkCigEJyr5U7wcU5?videoPreview=1 Data-assimilation and stability analysis of turbulent mean flows around airfoils close to stallnohttps://cassyni.com/events/KqJoSfkCigEJyr5U7wcU5?videoPreview=12023-02-15T16:00:00+00:002869.88Department of AeronauticsThe prediction of turbulent mean flows around airfoil near stalling conditions is still nowadays a challenge for numerical simulation based on Reynolds Averaged Navier Stokes equations. Transition and linear-eddy viscosity turbulence models classicaly used in the aeronautical industry do not properly capture the separation and reattachment of laminar/turbulent boundary layers that occur when increasing the angle of attack. This lack of accuracy prevents such turbulence models from properly predicting not only the mean flow but also the onset of low–frequency oscillations [3] or transverse cellular patterns [2] that are observed experimentally close to the stall angle. In this talk, we will show recent results of our group to improve (i) the turbulence mean flow estimation thanks to adjoint-based data-assimilation techniques [1] and (ii) the prediction of low-frequency oscillations and stall cells using global stability analysis of assimilated mean flows. Firstly, we will consider the onset of stall cells around a NACA4412 airfoil at Reynolds number Re=350 000. A transition/turbulence model is corrected using a full-state mean flow velocity field obtained from Direct Numerical Simulation. The stability analysis of the assimilated mean flow, based on the linearization of the RANS and turbulence models, reveals the existence of a three-dimensional steady global mode that gets unstable for angle of attack and transverse wavenumber in agreement with the experimental results. Those results will be discussed and compared to those obtained with methods recently proposed in the litterature and based on frozen eddy-viscosity approaches and eddy-viscosity fields estimated from DNS mean-flow. Secondly, we will consider the low-frequency flow-oscillations around a NACA0012 airfoil at angles of attack 10 degrees and various Reynolds numbers in the range [30000-50000]. In that case, velocity fields measured with Particle Image Velocimetry (PIV) are used to calibrate the turbulence model. The stability analysis of those assimilated mean flows predicts the existence of an unstable low-frequency global mode that may explain bursting events observed in the mean flow. We will conclude this talk by discussing the limit of our approach and the remaining challenges. https://cassyni-user-files-prod.s3.amazonaws.com/64R5wGdLWrjKU1LNYi8Rsc https://cassyni.com/slides/outline/3o5L2ruNQ1SifvKe1orFC1 https://cassyni.com/events/3o5L2ruNQ1SifvKe1orFC1/abstract https://cassyni-user-files-prod.s3.amazonaws.com/WY9RQwJAJdKYCBcQiaa6pn https://cassyni.com/events/3o5L2ruNQ1SifvKe1orFC1?videoPreview=1 R solver approach to the maximal regularity and free bounary problem for the Navier Stokes equationsnohttps://cassyni.com/events/3o5L2ruNQ1SifvKe1orFC1?videoPreview=12022-12-05T17:30:00+00:004473.84Journal of Mathematical Fluid MechanicsFirst, I will talk about the R solver method created by myself to prove the maximal regularity for the initial-boundary problem with non-homogeneous boundary date. By using this method, I proved the Lp in time and Lq in space maximal regularity theorem for the Stokes equations with free boundary conditions. The idea of R solver is based on Weis operator valued Fourier multiplier theorem. As an application, I will talk about the local and global wellposedness of free boundary problem of the Navier-Stokes equations.https://cassyni-user-files-prod.s3.amazonaws.com/WY9RQwJAJdKYCBcQiaa6pn https://cassyni.com/events/G9HSBx5VNTHaZbZSzAQyL9/abstract https://cassyni-user-files-prod.s3.amazonaws.com/F6aVQERhKtoVmXE9CafLt6 https://cassyni.com/slides/outline/Ai9ngRxiYRCWAjKDPFRBLh https://cassyni.com/events/Ai9ngRxiYRCWAjKDPFRBLh/abstract https://cassyni-user-files-prod.s3.amazonaws.com/7HKoR7yWExwKqYBCXKWG2a https://cassyni.com/events/Ai9ngRxiYRCWAjKDPFRBLh?videoPreview=1 Celebrating the launch of Nature Water - Part 2: Focus on water investments and affordabilitynohttps://cassyni.com/events/Ai9ngRxiYRCWAjKDPFRBLh?videoPreview=12023-02-01T16:00:00+00:003398.48Nature WaterTo celebrate the launch of Nature Water, we have organized a series of webinars with some of the authors from the first issue. In this second webinar, editor Karin Sjöstrand will be talking to Tom Mueller about uneven benefits of water infrastructure spending and with Benjamin Rachunok about water affordability.https://cassyni-user-files-prod.s3.amazonaws.com/7HKoR7yWExwKqYBCXKWG2a https://cassyni.com/slides/outline/8kHZU4mfFy4dsS9RT3xjLH https://cassyni.com/events/8kHZU4mfFy4dsS9RT3xjLH/abstract https://cassyni-user-files-prod.s3.amazonaws.com/6KzS2jafQGWK1phBe3kx7G https://cassyni.com/events/8kHZU4mfFy4dsS9RT3xjLH?videoPreview=1 Hyperbolic elastic wavesnohttps://cassyni.com/events/8kHZU4mfFy4dsS9RT3xjLH?videoPreview=12024-10-29T14:00:00+00:003736.04MetaMATHyperbolic metasurfaces have been offering an interesting platform to tailor waves, enabling subdiffractional wave propagation and enhanced wave-matter interactions thanks to their anisotropic features and open-topology dispersion. In this work, I will discuss their implementation for elastic waves, and the application of the peculiar propagation features of hyperbolic surface waves in complex geometries. I discuss in particular the emergence of hyperbolic wave attractors in oddly shaped cavities formed by extremely anisotropic media, and the design and implementation of hyperbolic lenses that mimic the problem of optimal airplane boarding in an analog-domain computing platform driven by hyperbolic surface waves.https://cassyni-user-files-prod.s3.amazonaws.com/6KzS2jafQGWK1phBe3kx7G https://cassyni.com/events/3ooX1EJQsPXcULS5SaFjc9/seminar/qa https://cassyni.com/slides/outline/3ooX1EJQsPXcULS5SaFjc9 https://cassyni.com/events/3ooX1EJQsPXcULS5SaFjc9/abstract https://cassyni-user-files-prod.s3.amazonaws.com/7V3qmLTLs3UCYHT4Kkegar https://cassyni.com/events/3ooX1EJQsPXcULS5SaFjc9?videoPreview=1 A quasi-optimal space-time finite element method for parabolic equationsnohttps://cassyni.com/events/3ooX1EJQsPXcULS5SaFjc9?videoPreview=12025-01-23T13:00:00+00:002982.04MOX Laboratory - Department of MathematicsWe outline the (potential) advantages of simultaneous space-time discretisations of parabolic evolution equations, and illustrate them with some numerical results. Other than for elliptic equations there is not one obvious variational formulation, and we present several possibilities. They have in common that the bilinear form is not coercive so that one has to resort to minimal residual discretisations, in most cases in a dual norm which leads to a saddle point problem. We present some technical details concerning adaptive mesh refinement, the construction of uniformly bounded Fortin interpolators, and optimal preconditioning.https://cassyni-user-files-prod.s3.amazonaws.com/7V3qmLTLs3UCYHT4Kkegar https://cassyni.com/events/J8dfTgaX12WxcWEN2JEB2d/seminar/qa https://cassyni.com/slides/outline/J8dfTgaX12WxcWEN2JEB2d https://cassyni.com/events/J8dfTgaX12WxcWEN2JEB2d/abstract https://cassyni-user-files-prod.s3.amazonaws.com/RiK8nfjMCD3HnRotGTLvZt https://cassyni.com/events/J8dfTgaX12WxcWEN2JEB2d?videoPreview=1 Light and temperature regulation of leaf morphogenesis in Arabidopsisnohttps://cassyni.com/events/J8dfTgaX12WxcWEN2JEB2d?videoPreview=12024-10-09T12:00:00+00:002465.36New PhytologistLeaves are the main photosynthetic organs in plants, and their anatomy is optimized for light interception and gas exchange. Although each species has a characteristic leaf anatomy, which depends on the genotype, leaves also show a large degree of developmental plasticity. Light and temperature regulate leaf development from primordia differentiation to late stages of blade expansion. While the molecular mechanisms of light and temperature signaling have been mostly studied in seedlings, in the latest years, research has focused on leaf development. Here, I will describe the latest work carried out in the environmental regulation of Arabidopsis leaf development, comparing signaling mechanisms between leaves and seedlings, highlighting the new discoveries, and pointing out the most exciting open questions.https://cassyni-user-files-prod.s3.amazonaws.com/RiK8nfjMCD3HnRotGTLvZt https://cassyni.com/slides/outline/XU8yi93grPTvViXxBXNVhP https://cassyni.com/events/XU8yi93grPTvViXxBXNVhP/abstract https://cassyni-user-files-prod.s3.amazonaws.com/TweeGc753PTaMEVNedFK6e https://cassyni.com/events/XU8yi93grPTvViXxBXNVhP?videoPreview=1 Data Efficient, Robust, and Interpretable Deep Reinforcement Learning for Robotics and Dynamical Systemsnohttps://cassyni.com/events/XU8yi93grPTvViXxBXNVhP?videoPreview=12024-10-18T19:00:00+00:003483.28AI Institute in Dynamic SystemsDeep reinforcement learning has achieved outstanding success in learning optimal control strategies directly from high-dimensional data by exploiting the expressive power of neural networks. However, neural network-based control policies tend to be over-parametrized, which means they need large amounts of training data, show limited robustness, and lack interpretability. These drawbacks become even more severe when controlling dynamical systems requiring real-world interaction and expensive simulation platforms, e.g., robots and fluids. In this talk, we will look at how to improve sample efficiency, robustness, and generalization in deep reinforcement learning through (i) unsupervised learning of low-dimensional data representations for robotics, (ii) sparse dictionary learning of control policies for parametric partial differential equations, and (iii) neural ordinary differential equations to blend physics and machine learning and to achieve energy-efficient control.https://cassyni-user-files-prod.s3.amazonaws.com/TweeGc753PTaMEVNedFK6e https://cassyni.com/events/Lbsgh6p9CKHSyShvZz8okZ/seminar/qa https://cassyni.com/slides/outline/Lbsgh6p9CKHSyShvZz8okZ https://cassyni.com/events/Lbsgh6p9CKHSyShvZz8okZ/abstract https://cassyni-user-files-prod.s3.amazonaws.com/UMq1pZzf6WYKtbTHiV9L2S https://cassyni.com/events/Lbsgh6p9CKHSyShvZz8okZ?videoPreview=1 Characterization and Control of Unsteady Separation on Swept Wingsnohttps://cassyni.com/events/Lbsgh6p9CKHSyShvZz8okZ?videoPreview=12024-11-18T14:00:00+00:003446.92AIAA JournalLarge transient excursions in angle of attack promote unsteady separation and dynamic stall over a wing, allowing it to briefly exceed static-stall conditions but also inducing potentially undesirable variations in aerodynamic loading or structural response. This phenomenon is prevalent in a number of engineering applications, including helicopter rotors, maneuvering aircraft, wind turbines, and wing–gust/wing-wake encounters. Thus, its prediction and control are of great interest.  Our group at AFRL has performed a large computational campaign over recent years coving a broad range of flow conditions, planforms, and kinematics to uncover the viscous mechanisms preceding stall onset.  In these studies, we have documented the dominant role of a small-scale laminar separation bubble (LSB) on the initiation of dynamic stall, which guided the development of a novel low amplitude, high-frequency control strategy to exploit the LSB dynamics for transient stall suppression.  Although originally designed for nominally 2D wing sections, the control technique was successfully extended to finite wings because by exploiting the mostly spanwise-uniform LSB prior to stall. Swept wings exhibit a similar LSB stall precursor state, yet their eventual stall behavior (transient tip stall) is drastically different than the dynamic center-wing stall of its straight wing counterpart. Despite this, the targeted, high-frequency control is also remarkably successful at also suppressing tip stall, demonstrating the dominant and somewhat universal nature of the LSB across relevant configurations and its potential for manipulation. The presentation will provide an overview of the swept-wing separation control, while also highlighting a promising passive control strategy through micro-cavity actuation.https://cassyni-user-files-prod.s3.amazonaws.com/UMq1pZzf6WYKtbTHiV9L2S https://cassyni.com/slides/outline/U1bkPMX1nBbHU2EPXrzYAZ https://cassyni.com/events/U1bkPMX1nBbHU2EPXrzYAZ/abstract https://cassyni-user-files-prod.s3.amazonaws.com/ESCWxbVy2agQUMtRuhMM1p https://cassyni.com/events/U1bkPMX1nBbHU2EPXrzYAZ?videoPreview=1 Occupational exposure to organic solvents and risk of bladder cancernohttps://cassyni.com/events/U1bkPMX1nBbHU2EPXrzYAZ?videoPreview=12024-11-21T12:00:00+00:00759.76National Institutes of HealthBACKGROUND: Bladder cancer has been linked to several occupations that involve the use of solvents, including those used in the dry-cleaning industry. OBJECTIVES: We evaluated exposure to solvents and risk of bladder cancer in 1182 incident cases and 1408 controls from a population-based study. METHODS: Exposure to solvents was quantitatively assessed using a job-exposure matrix (CANJEM). Exposure to benzene, toluene and xylene often co-occur. Therefore, we created two additional sets of metrics for combined benzene, toluene and xylene (BTX) exposure: (1) CANJEM-based BTX metrics and (2) hybrid BTX metrics, using an approach that integrates the CANJEM-based BTX metrics together with lifetime occupational histories and exposure-oriented modules that captured within-job, respondent-specific details about tasks and chemicals. Adjusted odds ratios (ORs) and 95% confidence intervals (95% CI) were estimated using logistic regression. RESULTS: Bladder cancer risks were increased among those ever exposed to benzene (OR = 1.63, 95% CI: 1.14–2.32), toluene (OR = 1.60, 95% CI: 1.06–2.43), and xylene (OR = 1.67, 95% CI: 1.13–2.48) individually. We further observed a statistically significant exposure-response relationship for cumulative BTX exposure, with a stronger association using the hybrid BTX metrics (ORQ1vsUnexposed = 1.26, 95% CI: 0.83–1.90; ORQ2vsUnexposed = 1.52, 95% CI: 1.00–2.31; ORQ3vsUnexposed = 1.88, 95% CI: 1.24–2.85; and ORQ4vsUnexposed = 2.23, 95% CI: 1.35–3.69) (p-trend=0.001) than using CANJEM-based metrics (p-trend=0.02). IMPACT: There is limited evidence about the role of exposure to specific organic solvents, alone or in combination on the risk of developing bladder cancer. In this study, workers with increasing exposure to benzene, toluene, and xylene as a group (BTX) had a statistically significant exposure-response relationship with bladder cancer. Future evaluation of the carcinogenicity of BTX and other organic solvents, particularly concurrent exposure, on bladder cancer development is needed.https://cassyni-user-files-prod.s3.amazonaws.com/ESCWxbVy2agQUMtRuhMM1p https://cassyni.com/events/6mimPxhSuVmyLGFDfJnQ1j/seminar/qa https://cassyni.com/slides/outline/6mimPxhSuVmyLGFDfJnQ1j https://cassyni.com/events/6mimPxhSuVmyLGFDfJnQ1j/abstract https://cassyni-user-files-prod.s3.amazonaws.com/MK39j9tofBKiLqmDNJ3oMY https://cassyni.com/events/6mimPxhSuVmyLGFDfJnQ1j?videoPreview=1 A Decade of ERPO: what does the evidence say about the use, effectiveness and opportunities for improving implementation and impact of this important firearm violence prevention tool?nohttps://cassyni.com/events/6mimPxhSuVmyLGFDfJnQ1j?videoPreview=12024-11-15T16:30:00+00:003601.08Sage PublishingERPO is a promising firearm violence prevention policy intervention. This Special Collection will focus on three topic areas: 1) How ERPO laws are being implemented and the factors associated with good implementation outcomes 2) Evaluations of ERPO impact on violence indicators 3) Commentaries that include evidence-informed recommendations for policy development or implementation California enacted the first modern ERPO law in 2014 with an effective date of January 1, 2016. In 2024, 21 states and the District of Columbia have an ERPO law. As we approach the 10th year of ERPO implementation, tens of thousands of ERPO orders have been issued. While there have been several descriptive studies, and accumulating evidence from hypothesis-testing research is pointing to associations between ERPO use/ERPO laws and suicides averted, many questions remain. We lack descriptive evidence from most states where ERPO is law, comparisons of different implementation models are lacking, and few papers address population impacts on homicide and suicide rates. In addition, understanding the equity implications of the policy and its implementation, especially the underutilization by communities that have high levels of firearm homicide (e.g., Black, Indigenous, and People of Color) and firearm suicide (e.g., veterans), is in need of rigorous and thoughtful scholarship. Questions about how advocacy has impacted the adoption, design and implementation of ERPO hold insights with broad implications for advancing public health. This collection will provide a comprehensive platform to guide the next 10 years of ERPO policy development and implementation.https://cassyni-user-files-prod.s3.amazonaws.com/MK39j9tofBKiLqmDNJ3oMY https://cassyni.com/events/7GNNSeLyLxL2L2n7Fk5CH3/seminar/qa https://cassyni.com/slides/outline/7GNNSeLyLxL2L2n7Fk5CH3 https://cassyni.com/events/7GNNSeLyLxL2L2n7Fk5CH3/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Vkje8ow2vt2xTniXpoM2vS https://cassyni.com/events/7GNNSeLyLxL2L2n7Fk5CH3?videoPreview=1 A Brief History of Plasticsnohttps://cassyni.com/events/7GNNSeLyLxL2L2n7Fk5CH3?videoPreview=12024-11-21T14:30:00+00:001875.04Cambridge PrismsThe appreciation or reception of materials can create a positive or a negative reaction in the user and an individual’s understanding of materials comes from their own experiential knowledge, influence of others, and cultural perception. The condemnation of the overuse of plastics materials and their impact on the environment when they become waste has, understandably, meant that today the cultural perception of plastics is largely that they are cheap, rubbish, throw away—all bad news. This position of negativity has been reached because we currently see the mismanagement of plastics waste as it blows about in the wind; we see it as rubbish in our streets, and as detritus in the oceans. However, our relationships with the material family, over the time they have existed, have had a varied and turbulent history with different perspectives generated by different people at different times. This article will briefly explore ‘a’, rather than ‘the’, history of the use of plastics with the aim of putting the current societal relationship with them into context.https://cassyni-user-files-prod.s3.amazonaws.com/Vkje8ow2vt2xTniXpoM2vS https://cassyni.com/slides/outline/qEiw8ECWvEwwAXseq5QHb https://cassyni.com/events/qEiw8ECWvEwwAXseq5QHb/abstract https://cassyni-user-files-prod.s3.amazonaws.com/YWLsfGZVDvEF4WRk4FQXQS https://cassyni.com/events/qEiw8ECWvEwwAXseq5QHb?videoPreview=1 Local mechanics: from crumpled sheets to origami and kirigaminohttps://cassyni.com/events/qEiw8ECWvEwwAXseq5QHb?videoPreview=12024-10-23T13:00:00+00:002960.68Department of Aeronautics and AstronauticsConsider a flat sheet of paper - bending it slightly creates a smooth continuous shape. However, large, constrained deformations (e.g. crumpling) result in the emergence of localised features, in this case a network of creases. After opening the crumpled sheet, the presence and behaviour of the creases is critical to the deformation characteristics of the global sheet. Similarly, introducing cuts into a sheet can drastically affect its mechanical behaviour. For example, increasing stretchability or introducing out-of-plane buckling modes. Understanding the influence of local features, and concisely describing their mechanics, will enable better predictions of the collapse of thin-walled structures but also support the creation of innovative shape-changing devices. In this talk Martin will describe novel analysis techniques for localised features and their applications in the design of deployable structures and energy dissipating devices. Image credit: [Chinh Le Duc (Unsplash)](https://unsplash.com/photos/assorted-color-star-themed-decors-poK5c-QWy1E).https://cassyni-user-files-prod.s3.amazonaws.com/YWLsfGZVDvEF4WRk4FQXQS https://cassyni.com/events/Q4SY8Wrhft5rpqU7RKLwCH/seminar/qa https://cassyni.com/slides/outline/Q4SY8Wrhft5rpqU7RKLwCH https://cassyni.com/events/Q4SY8Wrhft5rpqU7RKLwCH/abstract https://cassyni-user-files-prod.s3.amazonaws.com/GuuF2rJsG7GeNsDCCMoTT4 https://cassyni.com/events/Q4SY8Wrhft5rpqU7RKLwCH?videoPreview=1 Radical Chemistry in Organic Synthesis IInohttps://cassyni.com/events/Q4SY8Wrhft5rpqU7RKLwCH?videoPreview=12025-02-12T13:00:00+00:008413.8Thieme GroupThe introduction of photoredox catalysis as a tool in organic synthesis has transformed radical chemistry from being a curiosity with low practicability into an extremely powerful area of synthetic methodology. Some highlights of this chemistry, as well as coverage of more fundamental radical chemistry, are presented in the Science of Synthesis volumes on free radicals, edited by today's chairs Louis Fensterbank and Cyril Ollivier.https://cassyni-user-files-prod.s3.amazonaws.com/GuuF2rJsG7GeNsDCCMoTT4 https://cassyni.com/slides/outline/JdJtczjvqqznRyDspQM9Cq https://cassyni.com/events/JdJtczjvqqznRyDspQM9Cq/abstract https://cassyni-user-files-prod.s3.amazonaws.com/9NVq1L64iv9uMufainAfmx https://cassyni.com/events/JdJtczjvqqznRyDspQM9Cq?videoPreview=1 Immune-mediated diseases and climate changenohttps://cassyni.com/events/JdJtczjvqqznRyDspQM9Cq?videoPreview=12024-06-20T14:00:00+00:005364.64Frontiers in ScienceIn this Frontiers Forum Deep Dive session on 20 June 2024, Dr Kari Nadeau and Prof Ioana Agache explored links between climate change and immune dysregulation, and solutions for reducing climate-related impacts on human health. They were joined for a panel discussion and question and answer session by Dr John Balmes, Prof Stephen Holgate, Prof Edward Maibach, and Dr John Balbus. The session brought together the authors of the Frontiers in Science lead article ‘Immune-mediated disease caused by climate change-associated environmental hazards: mitigation and adaptation’ to discuss the urgent need for equitable, multilevel solutions for minimizing environmental health hazards associated with climate change. https://cassyni-user-files-prod.s3.amazonaws.com/9NVq1L64iv9uMufainAfmx https://cassyni.com/slides/outline/K7xVfgPTHJYqRjkmQqdwU9 https://cassyni.com/events/K7xVfgPTHJYqRjkmQqdwU9/abstract https://cassyni-user-files-prod.s3.amazonaws.com/S4qxZ8AKWPbgf2Jx8KWfP4 https://cassyni.com/events/K7xVfgPTHJYqRjkmQqdwU9?videoPreview=1 Stomatal form and function in the light side of the leafnohttps://cassyni.com/events/K7xVfgPTHJYqRjkmQqdwU9?videoPreview=12024-10-22T13:00:00+00:001828.68The New Phytologist FoundationMost plants have all or most of their stomata in the lower (abaxial) leaf side, whereas grasses and many other herbs, including the model plant Arabidopsis thaliana (Arabidopsis), have high stomatal numbers also on the upper (adaxial) leaf surface. Most studies on stomatal development and guard cell signalling have focused on abaxial stomata and very little is known on the formation and role of adaxial stomata in plants. Stomatal ratio describes the distribution of stomata between upper and lower leaf surfaces. How stomatal ratio is determined in plants remains unclear. Our recent work indicates that: i) mechanisms that govern stomatal development in the adaxial and abaxial epidermis in Arabidopsis are at least partly different, ii) adaxial and abaxial stomatal development and conductance respond differently to changes in environmental conditions, leading to changes in stomatal ratio and stomatal conductance ratio; and iii) stomatal ratio is positively related with yield in tomatoes. Thus, understanding the mechanisms of adaxial stomatal development and how stomatal ratio is adjusted in plants can help to breed crops with improved yield.https://cassyni-user-files-prod.s3.amazonaws.com/S4qxZ8AKWPbgf2Jx8KWfP4 https://cassyni.com/slides/outline/S32xKFSoRiJcvYkLnHCscq https://cassyni.com/events/S32xKFSoRiJcvYkLnHCscq/abstract https://cassyni-user-files-prod.s3.amazonaws.com/8YyoAuNVvsFfPKvcVxDDJ6 https://cassyni.com/events/S32xKFSoRiJcvYkLnHCscq?videoPreview=1 Ecosystem Support for Black Women Entrepreneursnohttps://cassyni.com/events/S32xKFSoRiJcvYkLnHCscq?videoPreview=12024-11-20T20:00:00+00:00711.36Center for Black Entrepreneurship, Spelman CollegeNo abstracthttps://cassyni-user-files-prod.s3.amazonaws.com/8YyoAuNVvsFfPKvcVxDDJ6 https://cassyni.com/events/5HoaNYGkzV3MnZJ4WAHXjK/seminar/qa https://cassyni.com/slides/outline/5HoaNYGkzV3MnZJ4WAHXjK https://cassyni.com/events/5HoaNYGkzV3MnZJ4WAHXjK/abstract https://cassyni-user-files-prod.s3.amazonaws.com/R4SoQK6G5dJeMG6tegirxE https://cassyni.com/events/5HoaNYGkzV3MnZJ4WAHXjK?videoPreview=1 Community Based Research and Action in Vulnerable Contextsnohttps://cassyni.com/events/5HoaNYGkzV3MnZJ4WAHXjK?videoPreview=12025-01-31T15:00:00+00:003816.12International Journal of Qualitative MethodsDrs. Hollist, Seibel, Vesely, and Lewin are experts in community-based research, specializing in collaborative partnerships with those communities to co-create interventions with the very community where it is needed. Drawing from diverse experiences across various contexts, they have developed a deep understanding of the complexities and nuances involved in effectively engaging communities in the development of sustainable support systems. In this seminar, they will share their insights, experiences, and strategies for conducting community-engaged, action-oriented research, emphasizing its value and practical methods for achieving meaningful outcomes.https://cassyni-user-files-prod.s3.amazonaws.com/R4SoQK6G5dJeMG6tegirxE https://cassyni.com/events/7m3bbxWPBmor9Vmd3rCATF/seminar/qa https://cassyni.com/slides/outline/7m3bbxWPBmor9Vmd3rCATF https://cassyni.com/events/7m3bbxWPBmor9Vmd3rCATF/abstract https://cassyni-user-files-prod.s3.amazonaws.com/CqvsjmrRhcF2Gbm5vXqwCA https://cassyni.com/events/7m3bbxWPBmor9Vmd3rCATF?videoPreview=1 Building Excellence: Structuring Editorial Boards for Impactnohttps://cassyni.com/events/7m3bbxWPBmor9Vmd3rCATF?videoPreview=12025-03-20T15:00:00+00:003358.32Topics at the heart of our communityOur Editorial Boards form the foundation for successful journals, from improving author service and decision-making to building and maintaining connections with the research community it serves. Join Ritu Dhand for insights on how to structure your editorial team to attract more high-quality submissions, and how editors can contribute to journal performance, be effective journal advocates, and maintain high standards in research integrity. https://cassyni-user-files-prod.s3.amazonaws.com/CqvsjmrRhcF2Gbm5vXqwCA https://cassyni.com/slides/outline/Eg84FXZjLBZdeJmCRHm6bw https://cassyni.com/events/Eg84FXZjLBZdeJmCRHm6bw/abstract https://cassyni-user-files-prod.s3.amazonaws.com/25jeamfmH378egh2bTS8ez https://cassyni.com/events/Eg84FXZjLBZdeJmCRHm6bw?videoPreview=1 Fc-optimized CD40 Agonistic Antibody Induces Tertiary Lymphoid Structures and Systemic Antitumor Immunity in Metastatic Cancer Patientsnohttps://cassyni.com/events/Eg84FXZjLBZdeJmCRHm6bw?videoPreview=12025-04-17T18:00:00+00:003291.44Center for Cancer TrainingCD40 agonistic antibodies are an attractive strategy to activate antigen-presenting cells (APC) and initiate antitumor immune responses. However, previous attempts to agonize this pathway have failed due to significant toxicity and poor on-target activity. We previously demonstrated that interactions between the antibody Fc domain and the inhibitory receptor FcgRIIB are critical for enhanced antitumor activity. Here, we present the results of a phase 1 study on intratumoral (IT) administration of an anti-CD40 agonistic antibody (2141-V11), Fc-engineered to enhance FcgRIIB binding (NCT04059588). We found that 2141-V11 was well-tolerated without dose-limiting toxicities. Among eleven evaluable metastatic cancer patients, six experienced tumor reduction, including two complete responses in melanoma and breast cancer. 2141-V11 induced regression in both injected and non-injected lesions, which correlated with systemic immune cell activation, robust tumor immune infiltration and formation of tertiary lymphoid structures (TLS) in complete responders. In several tumor models using mice humanized for CD40 and FcgRs, 2141-V11 induced de novo TLS formation in injected tumors, correlating with local and abscopal antitumor effects, systemic immune activation, and sustained antitumor immune memory. These findings demonstrate that IT 2141-V11 is safe and promotes effective and systemic antitumor immune responses in a subset of patients, supporting ongoing phase 2 studies and suggesting a unique mechanism of action for this Fc-enhanced immunotherapy.https://cassyni-user-files-prod.s3.amazonaws.com/25jeamfmH378egh2bTS8ez https://cassyni.com/slides/outline/9je1nh6Uwc2cFD3rQp46so https://cassyni.com/events/9je1nh6Uwc2cFD3rQp46so/abstract https://cassyni-user-files-prod.s3.amazonaws.com/JLH8m1wvVcM3ykYz6zHC1c https://cassyni.com/events/9je1nh6Uwc2cFD3rQp46so?videoPreview=1 Productivity And Reproducibility: Conflicting Pressures On Scientists?nohttps://cassyni.com/events/9je1nh6Uwc2cFD3rQp46so?videoPreview=12021-05-10T03:00:00+00:001944.0UKRNI first introduce the idea of quasi-cumulative science: where we think we are building on foundations of prior work, only to find that the earlier work is not solid. There is no single cause for this, but rather an unfortunate combination of factors that, taken together, have a detrimental effect on science. I discuss five of these, together with possible solutions, namely: 1. Publication bias 2. Citation bias. 3. P-hacking 4. Low statistical power 5. Obsession of funders/journals with novelty. https://cassyni-user-files-prod.s3.amazonaws.com/JLH8m1wvVcM3ykYz6zHC1c https://cassyni.com/events/QZ7mHq27WhZgeJTdDRTuNV/seminar/qa https://cassyni.com/slides/outline/QZ7mHq27WhZgeJTdDRTuNV https://cassyni.com/events/QZ7mHq27WhZgeJTdDRTuNV/abstract https://cassyni-user-files-prod.s3.amazonaws.com/2oWPrXxRFF2ewdzzVtzPAe https://cassyni.com/events/QZ7mHq27WhZgeJTdDRTuNV?videoPreview=1 Multiphysics Modeling in Biomechanics: Challenges and Opportunitiesnohttps://cassyni.com/events/QZ7mHq27WhZgeJTdDRTuNV?videoPreview=12025-02-18T03:00:00+00:002843.04The Auckland Bioengineering InstituteBiological media embed intrinsic complexity due to a multitude of factors, from the several elements involved to their different functions. Current knowledge, derived from advanced experimental-based models, still faces predictability and reliability issues limiting our ability to prevent the onset and evolution of pathologies. The present talk will run over a series of biomechanical models developed for soft active tissues, highlighting the remaining challenges and proposing possible routes for their investigation.https://cassyni-user-files-prod.s3.amazonaws.com/2oWPrXxRFF2ewdzzVtzPAe https://cassyni.com/slides/outline/KcdipzYs882fFCkHCwkueM https://cassyni.com/events/KcdipzYs882fFCkHCwkueM/abstract https://cassyni-user-files-prod.s3.amazonaws.com/ENPmNRVb9JFFnEAsBUJ5x2 https://cassyni.com/events/KcdipzYs882fFCkHCwkueM?videoPreview=1 Medical Data Governance and Sharing In Africanohttps://cassyni.com/events/KcdipzYs882fFCkHCwkueM?videoPreview=12024-11-26T12:00:00+00:001137.76NoneMedical imaging is vital to healthcare, yet Africa struggles with limited datasets due to infrastructural, financial, and policy challenges. Our work proposes AfriBiobank, a medical imaging biobank designed to consolidate data under unified ethical oversight, leveraging advanced technologies like FHIR, DICOM and semantic web standards for interoperability, scalability, and security. A distributed infrastructure with regional data centers could integrate federated learning approaches to uphold privacy standards during collaborative research and open barriers to diagnose tropical and rare diseases using data driven approach in the era of advanced artificial intelligence and foundational models.https://cassyni-user-files-prod.s3.amazonaws.com/ENPmNRVb9JFFnEAsBUJ5x2 https://cassyni.com/events/Xxqpz5iz6ZsX8sz6BJKdnV/seminar/qa https://cassyni.com/slides/outline/Xxqpz5iz6ZsX8sz6BJKdnV https://cassyni.com/events/Xxqpz5iz6ZsX8sz6BJKdnV/abstract https://cassyni-user-files-prod.s3.amazonaws.com/NR4zjd5ZKHTNroBKrwiwKC https://cassyni.com/events/Xxqpz5iz6ZsX8sz6BJKdnV?videoPreview=1 Nature Water Talks: interfacial solar evaporationnohttps://cassyni.com/events/Xxqpz5iz6ZsX8sz6BJKdnV?videoPreview=12025-02-26T14:00:00+00:003737.04Springer Nature Sustainable Development Goals ProgrammeInterfacial solar evaporation (ISE) provides a sustainable solution that extends beyond clean water production. In this webinar, we will talk to Jia Zhu (Nanjing University), Baoxia Mi (UC Berkeley), and Swee Ching Tan (National University of Singapore) about the opportunities and challenges of ISE in clean water production, mineral extraction, and so on. https://cassyni-user-files-prod.s3.amazonaws.com/NR4zjd5ZKHTNroBKrwiwKC https://cassyni.com/events/4oBbSV97xPR2wGTaCHwB6d/seminar/qa https://cassyni.com/slides/outline/4oBbSV97xPR2wGTaCHwB6d https://cassyni.com/events/4oBbSV97xPR2wGTaCHwB6d/abstract https://cassyni-user-files-prod.s3.amazonaws.com/LDiJwhKheoZXGwFz59GKRG https://cassyni.com/events/4oBbSV97xPR2wGTaCHwB6d?videoPreview=1 The mathematics and physics of wound healingnohttps://cassyni.com/events/4oBbSV97xPR2wGTaCHwB6d?videoPreview=12025-03-07T16:00:00+00:003852.04Journal of Fluid MechanicsI will discuss some recent work looking quantitatively at the process of wound healing using ideas from thermodynamics, continuum and statistical mechanics. Wound healing is a highly conserved process required for survival of an animal after tissue damage. The wound repair process is not only of great interest in its own right but is also a laboratory to study complex tissue dynamics and regeneration. Many wounds involve damage to an epithelial (barrier) tissue (like skin) that separates different regions of the body of a living organism. I will describe some recent work on studying wound healing in two dimensional epithelial tissues of a fruit fly pupal wing. This epithelium was chosen because it is transparent and accessible to sophisticated imaging techniques. We use live confocal time-lapse microscopy to follow the behaviour of cells in a tissue before and after wounding. I will focus on three cell-behaviours that are generally accepted to contribute to wound re-epithelialisation: cell shape deformation, cell division, and cell migration. I will describe how we are beginning to use a combination of mathematics, physics and biology to disentangle some of the organising principles behind the complex orchestrated dynamics that lead to wound healing.https://cassyni-user-files-prod.s3.amazonaws.com/LDiJwhKheoZXGwFz59GKRG https://cassyni.com/slides/outline/SXiBUZcDGXnSk1jraPKqo3 https://cassyni.com/events/SXiBUZcDGXnSk1jraPKqo3/abstract https://cassyni-user-files-prod.s3.amazonaws.com/BDk6RUMHaNLq9wuj5gBaEA https://cassyni.com/events/SXiBUZcDGXnSk1jraPKqo3?videoPreview=1 Synergies between resource use, biodiversity conservation and soil-plant-human healthnohttps://cassyni.com/events/SXiBUZcDGXnSk1jraPKqo3?videoPreview=12024-08-13T12:00:00+00:002460.04The New Phytologist FoundationAnno 2024 we live with > 8 billion people on planet Earth, all in need of food, energy, clean water, air and a home. Despite all our technical innovations humans remain critically dependent on natural resources, yet we consuming these faster than they can regenerate and thereby cross our planetary boundaries. We urgently need to shift to sustainable consumption and production to enable conservation and regeneration of natural habitats and to ensure a habitable planet for future generations. To do so we need to (re)value biodiversity, conserve indigenous knowledge and manage our ecosystems wisely. Innovations in plant and soil science can play an important role in this, in combination with technological advances, ecological knowledge and socio-economic inclusion. In this talk I will explore traditional and high-tech innovations to promote synergies between natural resource use, biodiversity conservation and soil, plant and human health.https://cassyni-user-files-prod.s3.amazonaws.com/BDk6RUMHaNLq9wuj5gBaEA https://cassyni.com/events/5nUoXrSAqJXBc2HaJGQVuX/seminar/qa https://cassyni.com/events/5nUoXrSAqJXBc2HaJGQVuX/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Kf7r71pAxjSMRvLNJMu2pN https://cassyni.com/slides/outline/2KwaD4uVm6eYaKz1ec2YNh https://cassyni.com/events/2KwaD4uVm6eYaKz1ec2YNh/abstract https://cassyni-user-files-prod.s3.amazonaws.com/98LeYxP9HpWbNKZpkmg5jL https://cassyni.com/events/2KwaD4uVm6eYaKz1ec2YNh?videoPreview=1 Nonlinearly-Stable High-Order Methods on Simplices with Improved Efficiencynohttps://cassyni.com/events/2KwaD4uVm6eYaKz1ec2YNh?videoPreview=12024-12-06T17:00:00+00:001683.08JKW Symposium TeamThis presentation reviews two efficient new nonlinearly-stable high-order methods applicable to simplices, both of which have the summation-by-parts property where integration-by-parts is mimicked discretely, which enables proofs of entropy stability. Both methods exploit a tensor-product structure on simplices to achieve efficiencies on simplices comparable to methods with a tensor-product structure developed for quadrilaterals and hexahedra. In the first approach presented, the tensor-product form is achieved through a collapsed coordinate transformation, an idea that has been used in the past. Through the development of schemes exploiting this strategy while having the summation-by parts property, entropy stability can be proven, thus producing methods with the same accuracy as existing entropy-stable multidimensional summation-by-parts operators with substantially reduced computational cost. The second new approach, tensor-product split-simplex operators, splits the simplices into quadrilateral or hexahedral subdomains, maps tensor-product summation-by-parts operators onto these subdomains, and reassembles into multidimensional operators using a continuous interface formulation. This approach is readily used in an entropy-stable framework as a result of the summation-by-parts property and also leads to substantial efficiency improvements relative to existing multidimensional summation-by-parts operators. https://cassyni-user-files-prod.s3.amazonaws.com/98LeYxP9HpWbNKZpkmg5jL https://cassyni.com/events/FfStTXNfcTbWTYHboqAs3T/seminar/qa https://cassyni.com/slides/outline/FfStTXNfcTbWTYHboqAs3T https://cassyni.com/events/FfStTXNfcTbWTYHboqAs3T/abstract https://cassyni-user-files-prod.s3.amazonaws.com/8LsNLfA5GPXxxhGnvL3dKU https://cassyni.com/events/FfStTXNfcTbWTYHboqAs3T?videoPreview=1 Future Leaders of Biophysicsnohttps://cassyni.com/events/FfStTXNfcTbWTYHboqAs3T?videoPreview=12025-03-27T14:00:00+00:005418.04Springer Nature Physics CommunityAn International Union for Pure and Applied Biophysics (IUPAB) On-line Event (4 x 15 min talks) for Biophysics Week, 2025. Organised by Springer/Nature, publisher of Biophysical Reviews. Open to all.https://cassyni-user-files-prod.s3.amazonaws.com/8LsNLfA5GPXxxhGnvL3dKU https://cassyni.com/events/CCuf8jqzYFisRqz3AAnuWd/seminar/qa https://cassyni.com/slides/outline/CCuf8jqzYFisRqz3AAnuWd https://cassyni.com/events/CCuf8jqzYFisRqz3AAnuWd/abstract https://cassyni-user-files-prod.s3.amazonaws.com/K12Tm589X3qcgxZVCbnGLn https://cassyni.com/events/NaYyDiwuAEH26pyaTqgEpm/abstract https://cassyni-user-files-prod.s3.amazonaws.com/17w3USA68HCJ4ud2YERS9U https://cassyni.com/events/P5CaGQbRbgq56bWU4Gy365/seminar/qa https://cassyni.com/events/P5CaGQbRbgq56bWU4Gy365/abstract https://cassyni-user-files-prod.s3.amazonaws.com/5VyLE5Sqa9qv6CSGHEEJcv https://cassyni.com/events/YTX49PtPwPMLxLybyQSbxh/seminar/qa https://cassyni.com/slides/outline/YTX49PtPwPMLxLybyQSbxh https://cassyni.com/events/YTX49PtPwPMLxLybyQSbxh/abstract https://cassyni-user-files-prod.s3.amazonaws.com/HXiFLhsGovxmU6q5qHH7dY https://cassyni.com/events/YTX49PtPwPMLxLybyQSbxh?videoPreview=1 Chemical Synthesis and Catalysis in Germanynohttps://cassyni.com/events/YTX49PtPwPMLxLybyQSbxh?videoPreview=12025-04-16T09:00:00+00:005554.0Thieme GroupJoin us for this Thieme Cheminar, where leading researchers—Dr. John Molloy (Max Planck Institute), Dr. Martin Klein (Merck Group), Dr. Golo Storch (TU München), and Prof. Ala Bunescu (University of Bonn)—will showcase their cutting-edge work in Synthesis and Catalysis. The session will be chaired by SYNTHESIS editorial board member, Prof. Daniele Leonori.https://cassyni-user-files-prod.s3.amazonaws.com/HXiFLhsGovxmU6q5qHH7dY https://cassyni.com/events/He4vktUemejzhjGETMyF6d/abstract https://cassyni-user-files-prod.s3.amazonaws.com/23S6uHvAVwyH4W8hdZrM66 https://cassyni.com/events/VzH2uyemk6arbQW3RiXyEm/abstract https://cassyni-user-files-prod.s3.amazonaws.com/4dqXPt4fobsnqgw3Je47Sv https://cassyni.com/events/2pcoNP4ubv8NPnyXSi9WYu/seminar/qa https://cassyni.com/slides/outline/2pcoNP4ubv8NPnyXSi9WYu https://cassyni.com/events/2pcoNP4ubv8NPnyXSi9WYu/abstract https://cassyni-user-files-prod.s3.amazonaws.com/JwLxk9fpn6cBXo9unRp23G https://cassyni.com/events/2pcoNP4ubv8NPnyXSi9WYu?videoPreview=1 Volume 2: Improving Menstrual Health throughout the Reproductive Life Coursenohttps://cassyni.com/events/2pcoNP4ubv8NPnyXSi9WYu?videoPreview=12025-07-22T14:00:00+00:003629.28Women's Health"My passion for menstrual health has always been rooted in a desire to challenge taboos and create space for open, informed dialogue. The response to Volume 1 and our first Cassyni seminar was incredibly affirming—witnessing the engagement, curiosity, and shared experiences reminded me why this work matters. That success has not only fuelled my drive but also made it clear: there’s so much more to explore. Volume 2 and a second seminar are natural next steps in continuing this vital conversation that comes at a critical moment when global systems that support women's and menstrual health are being systematically targeted and dismantled." - Marybec Griffin, Guest Editor of the Special Collectionhttps://cassyni-user-files-prod.s3.amazonaws.com/JwLxk9fpn6cBXo9unRp23G https://cassyni.com/slides/outline/R3nzT9BXMX3qCJnhREpyWd https://cassyni.com/events/R3nzT9BXMX3qCJnhREpyWd/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Hg7qDbpskxLboMixCBwhu8 https://cassyni.com/events/R3nzT9BXMX3qCJnhREpyWd?videoPreview=1 Net Zero Missions for Marine & Contribution from Applied Biomimeticsnohttps://cassyni.com/events/R3nzT9BXMX3qCJnhREpyWd?videoPreview=12025-04-09T15:00:00+00:002687.04Department of AeronauticsThe global commitment to achieving net zero is driving rapid advancements in renewable energy, with marine renewable energy at the forefront of research and innovation. The focus extends beyond energy harvesting to efficient storage, transportation, and utilization, enabling sustainable operations at sea. However, the complex and dynamic marine environment presents significant challenges in ensuring safe and efficient energy production and use. Addressing these challenges requires the development of cutting-edge, energy-efficient technologies tailored for marine applications. This presentation explores novel approaches to enhancing energy efficiency in marine renewables and propulsion, emphasizing integrated solutions that bridge hydrodynamics, biomimetics, and propulsion efficiency. By leveraging innovative engineering and applied biomimetic principles, we aim to support the maritime sector’s transition toward a sustainable, net-zero future.https://cassyni-user-files-prod.s3.amazonaws.com/Hg7qDbpskxLboMixCBwhu8 https://cassyni.com/slides/outline/3KGQR4iS3NgRPZWR39SJpD https://cassyni.com/events/3KGQR4iS3NgRPZWR39SJpD/abstract https://cassyni-user-files-prod.s3.amazonaws.com/WdCt8dB1ev9JmbHUvXujuG https://cassyni.com/events/WUWJFDa199F44vmHgu2Y5s/abstract https://cassyni-user-files-prod.s3.amazonaws.com/2TEkCo2ohyRuZfoJ7BSEKp https://cassyni.com/events/6GjgyisHdi79uF1Sm7jEfX/abstract https://cassyni-user-files-prod.s3.amazonaws.com/FwdAbd1btkYY3sTtxVcmAE https://cassyni.com/events/8jyiD96upzseGBV1JodsPT/seminar/qa https://cassyni.com/slides/outline/8jyiD96upzseGBV1JodsPT https://cassyni.com/events/8jyiD96upzseGBV1JodsPT/abstract https://cassyni-user-files-prod.s3.amazonaws.com/BGX8u8mh9xHSmvARJ5than https://cassyni.com/events/8jyiD96upzseGBV1JodsPT?videoPreview=1 Azo derivatives of monoterpenes as selective anti-Helicobacter pylori agents and fine- tuning of membrane permeability by their reversible photoisomerizationnohttps://cassyni.com/events/8jyiD96upzseGBV1JodsPT?videoPreview=12025-06-20T12:30:00+00:001682.04Anti-Cancer Agents in Medicinal ChemistryHelicobacter pylori (Hp) infection affects nearly half of the global population. Current therapeutic options include the administration of a combination of antibiotics and proton pump inhibitors, although antimicrobial resistance rise remains a big concern. Phenolic monoterpenes, e.g., eugenol, vanillin, carvacrol, and thymol, have always attracted the scientific community for their antimicrobial activity and the possibility to be easily derivatized. The functionalization of such compounds through the conventional aryl diazotization reaction can generate two series of mono- and bis-azo derivatives (1–28). Moreover, the free phenolic moiety of the most active compounds was functionalized as well, through acetylation, (thio)carbamoylation and methoxylation reactions, leading to compounds 29-36, to investigate the antimicrobial activity of the group. The compounds were tested against four Hp strains including three clinical isolates, finding some potent and selective inhibitors of bacterial growth. The most active compounds 20 and 28, both nitro-azobenzene derivatives, displayed Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) values between 2 and 4 μg/mL, and were not cytotoxic against two normal cell lines (GES-1 and HIEC-6). Furthermore, to shed light on the selectivity of the compounds' antibacterial effect, the most potent anti-Hp derivatives 20 and 28 were tested against three additional bacterial species: two Gram-negative, e.g., Escherichia coli and Pseudomonas aeruginosa, and the Gram-positive Staphylococcus aureus. Given the presence of a photo-switchable azo moiety, compounds 30 and 34 were also embedded into liposomes to obtain light-sensitive membranes whose photo-responsiveness, release behaviour, and permeability towards Cl- ions were investigated. In liposomal bilayer the selected guests underwent reversible photoinduced isomerization upon irradiation with UV and visible light, alternately. Non-irradiated hybrid liposomes retained entrapped 5(6)-carboxyfluorescein (CF), slowing its spontaneous leakage, whereas UV-irradiation promoted CF release, due to guest trans-to-cis isomerization. Photoisomerization enhanced membrane permeability towards Cl- ions.https://cassyni-user-files-prod.s3.amazonaws.com/BGX8u8mh9xHSmvARJ5than https://cassyni.com/events/LFeWtQ3F8a8W9J6ke2EwP/seminar/qa https://cassyni.com/slides/outline/LFeWtQ3F8a8W9J6ke2EwP https://cassyni.com/events/LFeWtQ3F8a8W9J6ke2EwP/abstract https://cassyni-user-files-prod.s3.amazonaws.com/RPKTRg7FhHVi1BdNjiqMYz https://cassyni.com/events/LFeWtQ3F8a8W9J6ke2EwP?videoPreview=1 Acoustic Computation: Bridging effective medium theory to biomedical ultrasound imagingnohttps://cassyni.com/events/LFeWtQ3F8a8W9J6ke2EwP?videoPreview=12025-07-08T09:00:00+00:002760.04MetaMATIn this talk, we reflect on the emerging concepts on wave-scatterer interactions, connecting effective medium theory (EMT) with biomedical ultrasound imaging. The homogenization process of acoustic effective medium is complementary to the imaging process. This can be seen from the relationship between spatial functions and time-frequency processing. We believe that a fundamental understanding of the physical responses of effective medium and materials, such as causality constraints and sum rules, will be beneficial for the advancement of imaging technology, and vice versa. In the domain of ultrasound imaging technology, these principles manifest as absorption-dependent pulse-tissue interactions that reduce reflectance layer-wise for imaging fidelity. For example, we show our recent effort on a soft holographic meta-structure to modulate sound waves and focus on arbitrary regions at the imaging plane. This flexible design improves imaging clarity and accuracy by enabling dynamic focal control. The use of simplified and approximate effective medium is common, which can enhance efficiency and accuracy for specific medical ultrasound scenarios in the future. https://cassyni-user-files-prod.s3.amazonaws.com/RPKTRg7FhHVi1BdNjiqMYz https://cassyni.com/slides/outline/7G4XBigDuz92iUXr9f9173 https://cassyni.com/events/7G4XBigDuz92iUXr9f9173/abstract https://cassyni-user-files-prod.s3.amazonaws.com/6vREfZKynjmLpe8HbqhxNa https://cassyni.com/events/7G4XBigDuz92iUXr9f9173?videoPreview=1 Microbiome spectra and prevalent colibactin-associated mutational process in Japanese colorectal cancernohttps://cassyni.com/events/7G4XBigDuz92iUXr9f9173?videoPreview=12025-09-11T02:45:00+00:00674.24Microbiome Virtual International ForumThe rising incidence of colorectal cancer (CRC), particularly among younger patients, has become a major public health concern in Japan and worldwide. While the association between the gut microbiota and CRC is well recognized, its molecular basis remains unclear. We aimed to clarify this relationship by integrating whole-genome sequencing (WGS) and transcriptome data from CRC tissues with whole-genome metagenomic sequencing (WGMS) of fecal samples. We applied explainable artificial intelligence (AI) analysis to classify CRC into four microbiome-based subtypes and examined their clinical and molecular characteristics. Colibactin-associated mutational signatures (SBS88 and ID18) were analyzed as potential early clonal events. One subtype was enriched in younger patients and associated with poor prognosis. WGS revealed colibactin-associated mutational signatures in 97 of 138 patients (70.3%), with a higher prevalence in the younger subtype. APC hotspot mutations and frameshift deletions matching the colibactin-specific motif were observed in 12 patients (8.7%). CRCs with colibactin signatures were characterized by an immunosuppressive tumor microenvironment. Colibactin exposure is a common yet potentially modifiable risk factor for CRC in the Japanese population. Our findings highlight the potential of microbiome-based subclassification to provide clinical and biological insights into CRC, particularly in younger patients.https://cassyni-user-files-prod.s3.amazonaws.com/6vREfZKynjmLpe8HbqhxNa https://cassyni.com/slides/outline/ChatJ41QP5ChFJyYxGusgq https://cassyni.com/events/ChatJ41QP5ChFJyYxGusgq/abstract https://cassyni-user-files-prod.s3.amazonaws.com/CTFWLB9t5WbMK8BgSw1t46 https://cassyni.com/events/ChatJ41QP5ChFJyYxGusgq?videoPreview=1 How photonic metasurfaces are an enabling technology for Industry 4.0 applicationsnohttps://cassyni.com/events/ChatJ41QP5ChFJyYxGusgq?videoPreview=12026-01-30T15:00:00+00:003067.64UK Metamaterials NetworkThe widespread deployment of sensors is a vital step in the path to delivering smart and autonomous manufacturing processes, both to monitor what is being made, and to monitor the machines that are making the items. Not only must data be gathered, but it must be rapidly processed to extract the required information to act on at the time it is needed. This, however, requires small and lightweight instrumentation that can be deployed without interfering with ongoing processes, and complex manipulation of light to produce signals to be manipulated into the optimal form before being recorded. Traditional approaches have only had limited success in achieving these aims, however, metasurfaces offer a platform by which these barriers can be overcome. These types of measurements are restricted enough, for example using monochromatic or narrowband light, that traditional issues, such as chromatic aberrations, are avoided removing the need to deal with the more complicated design processes. Here I will talk about why the technology is a good fit for this task and the steps we are taking to move this technology out of the lab and into real world use on the shop floor. https://cassyni-user-files-prod.s3.amazonaws.com/CTFWLB9t5WbMK8BgSw1t46 https://cassyni.com/slides/outline/M6BpNEH2oSinDBJ9mmYyDF https://cassyni.com/events/M6BpNEH2oSinDBJ9mmYyDF/abstract https://cassyni-user-files-prod.s3.amazonaws.com/6kv5naqd4Jx7gBAMYUBRhG https://cassyni.com/events/M6BpNEH2oSinDBJ9mmYyDF?videoPreview=1 Tugging at the Heartstrings: The Importance and Aetiology of Cardiac Mechano-arrhythmogenesisnohttps://cassyni.com/events/M6BpNEH2oSinDBJ9mmYyDF?videoPreview=12025-04-29T04:00:00+00:004121.92The Auckland Bioengineering InstituteFeedback is an essential element of biological systems’ autoregulation, and fundamental to the adaptation of physiological activity to varying demands. A prime example is the heart – an electro-mechanical pump whose electrical excitation causes mechanical contraction of cardiomyocytes, involving a feedforward mechanism of electrically-triggered, calcium-induced calcium release from intracellular stores (‘excitation-contraction coupling’), and mechano-sensitive feedback by which the mechanical state of cardiomyocytes affects their electrical activity and calcium handling (‘mechano-electric coupling’). Although mechano-electric coupling is important for maintaining and fine-tuning normal cardiac function, it can also contribute to arrhythmias by causing aberrant electrophysiological behaviour (‘mechano-arrhythmogenesis’), particularly in cardiac diseases that alter the finely balanced physiological heterogeneity of passive and active mechanics of the heart. While the influence of mechano-electric coupling on the heart’s electrical activity is well established, the mechanisms and molecular identity of specific drivers underlying mechano-arrhythmogenesis are unclear. This seminar will describe ongoing work in our laboratory exploring the importance and aetiology of cardiac mechano-arrhythmogenesis.https://cassyni-user-files-prod.s3.amazonaws.com/6kv5naqd4Jx7gBAMYUBRhG https://cassyni.com/slides/outline/PZRqbeWezjVGa7miKTTbwB https://cassyni.com/events/PZRqbeWezjVGa7miKTTbwB/abstract https://cassyni-user-files-prod.s3.amazonaws.com/UtYWfUsSbvGCsTRuKxcv9t https://cassyni.com/events/PZRqbeWezjVGa7miKTTbwB?videoPreview=1 2-Keto-1,3-Indandiones, a Versatile Ingredients for the Synthesis of Medicinally Important Spirocycles, Bicyclesnohttps://cassyni.com/events/PZRqbeWezjVGa7miKTTbwB?videoPreview=12024-09-27T13:00:00+00:002738.36Thieme India ChemTalksThe talk will be focused on the development of novel synthetic methodologies under transition metal-free conditions. Design and development of various 2-keto-1,3-indandiones as important precursors for constructing various bicyclic, spiro cyclic systems with suitable reacting partners. Because 2-keto-1,3- indandione has the unique characteristics of having two sets of nucleophilic and electrophilic sites within the molecule. Accordingly, the reaction of arynes with 2-keto-1,3-indandiones provided dibenzobicyclo[3.2.1]octadienone core and the reaction of dimethyl acetylene dicarboxylate (DMAD) with 2/3-keto-1,3-Indandiones afforded spiro[4.4]nonane compounds in presence of a catalytic amount of DABCO. Moreover, the spiro[4.4]nonanes were transformed into highly conjugated pentafulvene motifs via unprecedented C-C bond rearrangement in an acidic medium. So much interesting and exciting chemistry is going on in my laboratory using 2-(2′-ketoalkyl)-1,3-indandione as one of the key, intriguing, starting materials. Finally, my group’s contributions towards the total synthesis of natural products will be highlighted in this talk. *Key take-aways for the attendees:* * Sustainable approaches. * Importance of transition metal-free approaches. * Importance of spiro-, bi-cyclic systems in medicinal chemistry. * Substrate design in the methodology development. * Total synthesis of natural products.https://cassyni-user-files-prod.s3.amazonaws.com/UtYWfUsSbvGCsTRuKxcv9t https://cassyni.com/slides/outline/Aia8Psh1aq6QMtmEfmVop1 https://cassyni.com/events/Aia8Psh1aq6QMtmEfmVop1/abstract https://cassyni-user-files-prod.s3.amazonaws.com/3EqteeiwYihHYSkzb9f6Bx https://cassyni.com/events/Aia8Psh1aq6QMtmEfmVop1?videoPreview=1 Catalysts of Change: How can Metascience and Interdisciplinary Research Empower ECRs?nohttps://cassyni.com/events/Aia8Psh1aq6QMtmEfmVop1?videoPreview=12025-06-27T13:00:00+00:005765.04Interdisciplinary research plays a pivotal role in advancing metascience, while metascience provides essential tools and frameworks to enhance interdisciplinary collaboration and innovation. This 90-minute symposium explores how the dynamic relationship between metascience and interdisciplinary research fosters improved research practices and networks. Four early career researchers (ECRs) from diverse disciplines share their experiences and insights, discussing how these fields mutually reinforce one another to drive scientific progress. The symposium features four short presentations, each reflecting on the speakers’ experience as an interdisciplinary researcher and the broader impact of their work: * Anna Leung (psycholinguist and language teacher) bridges education and psychology theories in reading research to enhance knowledge dissemination and collaboration. * Elen Le Foll (corpus linguist and language teaching expert) focuses on promoting open science and open education practices in the humanities. * Shawn Hemelstrand (psychologist and methodologist) explores how statistics education and scientific communication enhance the reliability and accessibility of research findings. * Daniel Kristanto (engineer turned neuroscientist) integrates data science and metascience to develop frameworks that enable cross-disciplinary learning, fostering the transfer of impactful methods and insights across fields. Following the presentations, a 45-minute moderated panel discussion will provide a platform for exploring how ECRs can navigate the challenges of interdisciplinary research. The discussion focuses on the shared goals of metascience and interdisciplinary research, fostering dialogue on overcoming barriers, building collaborative networks, and driving meaningful progress in science. This symposium emphasises how the synergy between metascience and interdisciplinary collaboration inspires innovation and supports ECRs in their scientific growth. https://cassyni-user-files-prod.s3.amazonaws.com/3EqteeiwYihHYSkzb9f6Bx https://cassyni.com/events/BDDjSZLY2HeTMfJ8GCnc5K/abstract https://cassyni-user-files-prod.s3.amazonaws.com/2viSnd9URmQztBWHMJCZiE https://cassyni.com/events/Mas3XYSSeGCc2eHfZsfwPT/abstract https://cassyni-user-files-prod.s3.amazonaws.com/EqbzZNE6ity614PThuDwwk https://cassyni.com/slides/outline/pvsgCZT5x3xKcHcYk9D7b https://cassyni.com/events/pvsgCZT5x3xKcHcYk9D7b/abstract https://cassyni-user-files-prod.s3.amazonaws.com/UZk84LvhpJkUfv2UWqbjPC https://cassyni.com/events/pvsgCZT5x3xKcHcYk9D7b?videoPreview=1 Asymptotic links between signal processing, acoustic metamaterials and biologynohttps://cassyni.com/events/pvsgCZT5x3xKcHcYk9D7b?videoPreview=12022-09-07T12:00:00+00:001595.92UK Metamaterials NetworkThis study explores the asymptotic connections between acoustic metamaterials, cochlear-inspired biological structures, and signal processing frameworks, motivated by biomimicry’s potential to replicate nature’s efficient solutions. The analysis focuses on metamaterials composed of sub-wavelength resonators exploiting Minnaert resonance—air bubbles in water that strongly scatter sound at frequencies much lower than their size scale. An asymptotic approach is developed using a small parameter δ (the density ratio of air to water) to characterize low-frequency resonant modes via the eigenvalues and eigenvectors of a generalized capacitance matrix, a concept extending classical electrostatics. This framework enables efficient computation of resonant frequencies and modes, facilitating the design of graded metamaterial arrays that emulate cochlear frequency-position mappings and wave localization phenomena. Incorporation of nonlinear forcing terms models amplification and stability features akin to cochlear mechanics. Extending beyond physical structures, the resonant modes correspond to gammatone filters, linking the metamaterial response to established auditory signal processing models. Statistical analysis of natural sound amplitude distributions reveals low-dimensional parameterizations that, while limited in classification accuracy, suggest informative features for sound classification tasks. Inspired by the fruit fly olfactory system, a bio-inspired random projection and sparsification algorithm is introduced, demonstrating robustness improvements in musical genre classification under noise perturbations. The study also addresses the robustness of resonant frequencies to structural perturbations, showing stability consistent with biological cochlear resilience. These results provide a mathematically elegant platform for interdisciplinary exchange, advancing biomimetic metamaterial design, auditory signal processing, and understanding of biological sensory robustness.https://cassyni-user-files-prod.s3.amazonaws.com/UZk84LvhpJkUfv2UWqbjPC https://cassyni.com/slides/outline/EB8yqHja4PtpDHXRX6hwFj https://cassyni.com/events/EB8yqHja4PtpDHXRX6hwFj/abstract https://cassyni-user-files-prod.s3.amazonaws.com/GsiPaDgYmdhurXGVaaNSjY https://cassyni.com/events/EB8yqHja4PtpDHXRX6hwFj?videoPreview=1 Exploring Convergence: Emerging/Disruptive/Exponential Technologies (EDET)nohttps://cassyni.com/events/EB8yqHja4PtpDHXRX6hwFj?videoPreview=12024-09-24T23:00:00+00:003616.84Business SchoolThis seminar explores the convergence of Emerging, Disruptive, and Exponential Technologies (EDET), advocating for an integrated understanding of their collective impact over individual applications. EDET are characterized by unrealized practical applications, capacity to alter the status quo, continuous development, significant social and economic effects, radical novelty, fast growth, coherence, uncertainty, and quantitative doubling. The analysis introduces five "convergence lenses": the integration of physical and digital domains; the convergence of three-dimensional space (below, around, and above), enabling new data granularities; the inherent intersections of EDET themselves (e.g., AI, IoT, 6G); the data journey from raw data to wisdom (DIKW pyramid) for valuing applications; and the leveraging of technologies across converging industries and sectors, such as in climate resilience. It is argued that the relationships and intersections between technologies are more critical than isolated advancements. A key implication is the necessity of a comprehensive "converged impact framework," integrating considerations of trust, security, privacy, engagement, safety, resilience, accessibility, sustainability, and the entire life cycle of data and devices. The presentation critiques a technology-first approach, proposing a "right-to-left" decision-making framework. This framework prioritizes starting with quantifiable societal impact areas, like well-being in agriculture, to strategically guide technology development and deployment, thereby ensuring long-term benefits and mitigating potential environmental and social risks.https://cassyni-user-files-prod.s3.amazonaws.com/GsiPaDgYmdhurXGVaaNSjY https://cassyni.com/slides/outline/9EewNTGKfpMnpBp5WczwXb https://cassyni.com/events/9EewNTGKfpMnpBp5WczwXb/abstract https://cassyni-user-files-prod.s3.amazonaws.com/DKBunhtDWDc6HwCBcgtM7k https://cassyni.com/events/9EewNTGKfpMnpBp5WczwXb?videoPreview=1 The Invisible Risk: The Data-sharing Activities of Data Brokers and Information Leakagenohttps://cassyni.com/events/9EewNTGKfpMnpBp5WczwXb?videoPreview=12021-08-02T23:00:00+00:003235.04Business SchoolThe extensive, often opaque, data collection and sharing activities of data brokers present significant concerns regarding consumer information leakage. This study investigates the relationship between data exchange activities involving data brokers and the occurrence of information leakage observed on the dark web. Data was collected from various sources, including registrations from Vermont and California, third-party cookies scraped from S&P 1500 company websites (final sample of approximately 750 firms), competitor data from the Mergent database, and dark web posts monitored by DarkOwl from February 1st to July 31st, 2020. Information leakage was quantified by the number of unique dark web posts identifying breached data. The analysis reveals that a greater amount of data exchange activity between firms and data brokers, proxied by the presence of more third-party cookies on company websites, is positively associated with increased information leakage on the dark web. While a direct effect of data sharing among data brokers on overall information leakage was not initially observed, further analysis yielded nuanced findings. Registered data brokers generally exhibited lower information leakage, suggesting a potential "monitoring effect" from regulatory oversight or stronger security measures. However, registered data brokers with a higher number of competitors engaged in data sharing demonstrated an increased likelihood of information leakage. This indicates that while registration might signal internal security confidence, extensive sharing networks among data brokers, even registered ones (e.g., 47 registered brokers and 452 competitors in the refined sample), exacerbate systemic vulnerability and information leakage risks. The findings underscore the critical need for greater transparency and regulation within the data broker industry.https://cassyni-user-files-prod.s3.amazonaws.com/DKBunhtDWDc6HwCBcgtM7k https://cassyni.com/slides/outline/VVGLP7Jj4wzGLgoeKredyf https://cassyni.com/events/VVGLP7Jj4wzGLgoeKredyf/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Fm6jyQfmSLSwed39BN4ZmY https://cassyni.com/events/VVGLP7Jj4wzGLgoeKredyf?videoPreview=1 Novel unconventional superconductivity and phase-sensitive probesnohttps://cassyni.com/events/VVGLP7Jj4wzGLgoeKredyf?videoPreview=12025-06-19T01:00:00+00:001720.48ETOPIMThe study explores a novel class of unconventional superconductivity characterized by topologically obstructed pairing orders termed monopole pairing. This superconducting state emerges from the interplay of geometric phases, band topology, and electron interactions in systems such as doped magnetic Weyl semimetals. The analysis extends the concept of Berry phase from single-particle quantum states to Cooper pairs, revealing that pairing between Fermi surfaces with distinct monopole (Chern) charges induces a nonzero monopole charge for the Cooper pair. This topological feature enforces a nodal superconducting gap structure fundamentally distinct from known s-, p-, or d-wave symmetries, necessitating description via monopole harmonic functions rather than conventional spherical harmonics. The monopole pairing order exhibits a shifted angular momentum quantum number and breaks inversion symmetry, resulting in a total vorticity on the Fermi surface that differs from established unconventional superconductors. Proposed material realizations include magnetically doped Dirac semimetals where Weyl points and associated Fermi surfaces with opposite Chern numbers arise. Phase-sensitive Josephson junctions between monopole superconductors and conventional s-wave superconductors are designed to detect the unique angular momentum and topological signatures, including characteristic 2π and 4π periodicities linked to Majorana surface modes. The framework also predicts novel bulk-boundary correspondences, such as Majorana arcs connecting Fermi surface projections. This work provides a topological classification of superconducting orders beyond traditional paradigms and suggests experimental probes to identify monopole pairing, offering new avenues to investigate many-body effects in topological quantum materials.https://cassyni-user-files-prod.s3.amazonaws.com/Fm6jyQfmSLSwed39BN4ZmY https://cassyni.com/slides/outline/S2j74Kn3zk7dJzW5gCGgSq https://cassyni.com/events/S2j74Kn3zk7dJzW5gCGgSq/abstract https://cassyni-user-files-prod.s3.amazonaws.com/6WPPx3auPi3AqaxFxqqyXL https://cassyni.com/events/S2j74Kn3zk7dJzW5gCGgSq?videoPreview=1 Experimental validation of a three-dimensional water-like pentamode metamaterial fabricated via investment castingnohttps://cassyni.com/events/S2j74Kn3zk7dJzW5gCGgSq?videoPreview=12025-06-15T23:00:00+00:00743.28ETOPIMThis study presents the experimental validation of a three-dimensional water-like pentamode metamaterial fabricated via an innovative stereolithography (SLA)-assisted investment casting process. The motivation stems from the need for acoustic metamaterials replicating water’s elasticity matrix, which supports only hydrostatic stress, to enable applications such as acoustic lenses and cloaking. The pentamode unit cell was designed and optimized using finite element analysis to approximate the theoretical elasticity matrix of water, balancing geometric refinement with manufacturability constraints. Unlike common additive manufacturing methods, the investment casting approach offers high resolution, net-shape components, and reduced porosity and internal stresses, albeit with longer fabrication cycles and higher resource consumption. The sample was produced by printing a castable resin mold via SLA, followed by thermal burnout and aluminum casting under vacuum and gas pressure. To prevent water infiltration during acoustic testing, 1 mm thick CNC-machined walls were added, a dimension optimized through finite element modeling to maximize acoustic transmission. The experimental campaign involved acoustic transmission measurements at six frequencies between 10 and 60 kHz using a hydrophone and a three-axis robotic positioning system. Results showed that while the reference sample with only external walls exhibited high transmission (~0.95), the pentamode metamaterial’s transmission was significantly lower than expected, indicating fabrication or measurement challenges. Future work aims to refine specimen quality and explore compliant fillers to improve acoustic performance and enable more complex geometries.https://cassyni-user-files-prod.s3.amazonaws.com/6WPPx3auPi3AqaxFxqqyXL https://cassyni.com/slides/outline/5HVj7cc1ZWrNB13oQ5MLZK https://cassyni.com/events/5HVj7cc1ZWrNB13oQ5MLZK/abstract https://cassyni-user-files-prod.s3.amazonaws.com/FrEzFnipbYc6kvqU4WoyU2 https://cassyni.com/events/5HVj7cc1ZWrNB13oQ5MLZK?videoPreview=1 Microbial-plant interactions regulate soil organic phosphorus turnover and uptakenohttps://cassyni.com/events/5HVj7cc1ZWrNB13oQ5MLZK?videoPreview=12025-07-09T12:00:00+00:001139.56NoneOrganic forms of phosphorus are often major components of the total phosphorus pool in soil. Yet, it is generally assumed that plant uptake of phosphorus is determined solely by mineralisation, often by free-living microorganisms, of organic forms into so-called ‘plant-available’ inorganic forms. Here we challenge this idea and provide data indicating that ectomycorrhizal fungi can access and potentially take-up organic forms intact, thus contributing to host tree nutrition. We place these ideas in the context of forest community ecology using sub-tropical systems as an example. We then expand our ideas to consider grasslands, and explore how plants and their associated arbuscular mycorrhizal fungi may regulate turnover of organic phosphorus. The exploration of microbial mechanisms underpinning how plants acquire hitherto 'unavailable' forms of organic phosphorus is critical not only for our understanding of ecological processes, but also because we face a looming crisis in the supply of rock-phosphate for fertiliser production. https://cassyni-user-files-prod.s3.amazonaws.com/FrEzFnipbYc6kvqU4WoyU2 https://cassyni.com/slides/outline/7kjkM2qdkocrXwXMwmFyHF https://cassyni.com/events/7kjkM2qdkocrXwXMwmFyHF/abstract https://cassyni-user-files-prod.s3.amazonaws.com/WMbMa8H2WRozeXuSUfYKD8 https://cassyni.com/events/7kjkM2qdkocrXwXMwmFyHF?videoPreview=1 Research Inclusion as a Condition of Funding – RICOFnohttps://cassyni.com/events/7kjkM2qdkocrXwXMwmFyHF?videoPreview=12025-06-17T08:00:00+00:001905.12The Research on Research (RoR) Team### Why RICOF? Research needs to be serving communities which are most in need. Inclusive research increases scientific rigour, societal welfare, and brings economic impact. The RICOF project is taking place in stages. The presentation discussed activities taking place in the first stage of the project, which focuses on inclusive design in applications for funding. Subsequent stages will include a focus on research participants sex, gender and ethnicity. ### Delivering RICOF As part of the delivery of RICOF, training to applicants, funding committees and NIHR staff has been provided. This ensures that stakeholders are equipped with the skills to deliver the project and that guidelines published in connection to RICOF are implemented consistently across the organisation. In addition, guidelines are undergoing continuous improvement to ensure ongoing relevance. RICOF values feedback from the research community as inclusive design in research may be new to some. Programme teams are gathering feedback from applicants and public contributors. [NIHR Research Support Services](http://www.nihr.ac.uk/support-and-services/research-support-service) offer help to researchers in writing applications that meet inclusive design requirements. Currently, RICOF is being implemented across NIHR domestic research programmes. Funding programmes in Global Health and NIHR Infrastructure investment will be implemented throughout 2025/26 and 2026/27 respectively. The NIHR is actively working to align with the Health Research Authority to ensure that the work in preparing inclusive funding applications aligns with the requirements set out in the [HRA and MHRA’s Inclusion and Diversity Guidance](https://www.hra.nhs.uk/planning-and-improving-research/best-practice/increasing-diversity-people-taking-part-research/), thus, increasing efficiencies and avoiding duplication. ### Specific details to applications to NIHR Patient and Public Involvement continues its fundamental contribution to ensuring inclusive research design. RICOF and PPI requirements are overlapping but distinct. Both require applicants to think about how each will be built into the whole application to ensure that the scientific design as well as the budget required to deliver inclusive research and public and patient involvement are evident. Word count at application was not extended and there is no uplift in budget to accommodate RICOF. https://cassyni-user-files-prod.s3.amazonaws.com/WMbMa8H2WRozeXuSUfYKD8 https://cassyni.com/slides/outline/4nskBZUNXRE3KiDK6Czyvd https://cassyni.com/events/4nskBZUNXRE3KiDK6Czyvd/abstract https://cassyni-user-files-prod.s3.amazonaws.com/5u5oTrNBmYtJCjab4YpAdC https://cassyni.com/events/4nskBZUNXRE3KiDK6Czyvd?videoPreview=1 Prioritizing gut microbial SNPs linked to immunotherapy outcomes in NSCLC patients by integrative bioinformatics analysisnohttps://cassyni.com/events/4nskBZUNXRE3KiDK6Czyvd?videoPreview=12025-11-12T13:30:00+00:00729.4Microbiome Virtual International ForumBackground The human gut microbiome has emerged as a potential modulator of treatment efficacy for different cancers, including non-small cell lung cancer (NSCLC) patients undergoing immune checkpoint inhibitor (ICI) therapy. In this study, we investigated the association of gut microbial variations with response against ICIs by analyzing the gut metagenomes of NSCLC patients. Methods Strain identification from the publicly available metagenomes of 87 NSCLC patients, treated with nivolumab and collected at three different timepoints (T0, T1, and T2), was performed using StrainPhlAn3. Variant calling and annotations were performed using Snippy and associations between microbial genes and genomic variations with treatment responses were evaluated using MaAsLin2. Supervised machine learning models were developed to prioritize single nucleotide polymorphisms (SNPs) predictive of treatment response. Structural bioinformatics approaches were employed using MUpro, I-Mutant 2.0, CASTp and PyMOL to access the functional impact of prioritized SNPs on protein stability and active site interactions. Results Our findings revealed the presence of strains for several microbial species (e.g., Lachnospira eligens) exclusively in Responders (R) or Non-responders (NR) (e.g., Parabacteroides distasonis). Variant calling and annotations for the identified strains from R and NR patients highlighted variations in genes (e.g., ftsA, lpdA, and nadB) that were significantly associated with the NR status of patients. Among the developed models, Logistic Regression performed best (accuracy > 90% and AUC ROC > 95%) in prioritizing SNPs in genes that could distinguish R and NR at T0. These SNPs included Ala168Val (lpdA) in Phocaeicola dorei and Tyr233His (lpdA), Leu330Ser (lpdA), and His233Arg (obgE) in Parabacteroides distasonis. Lastly, structural analyses of these prioritized variants in objE and lpdA revealed their involvement in the substrate binding site and an overall reduction in protein stability. This suggests that these variations might likely disrupt substrate interactions and compromise protein stability, thereby impairing normal protein functionality. Conclusion The integration of metagenomics, machine learning, and structural bioinformatics provides a robust framework for understanding the association between gut microbial variations and treatment response, paving the way for personalized therapies for NSCLC in the future. These findings emphasize the potential clinical implications of microbiome-based biomarkers in guiding patient-specific treatment strategies and improving immunotherapy outcomes.https://cassyni-user-files-prod.s3.amazonaws.com/5u5oTrNBmYtJCjab4YpAdC https://cassyni.com/events/AhWU3x7LH7tnmKdE7UxN13/seminar/qa https://cassyni.com/slides/outline/AhWU3x7LH7tnmKdE7UxN13 https://cassyni.com/events/AhWU3x7LH7tnmKdE7UxN13/abstract https://cassyni-user-files-prod.s3.amazonaws.com/TJqJzc623DMqnxYzo6WxM4 https://cassyni.com/events/AhWU3x7LH7tnmKdE7UxN13?videoPreview=1 How optimal protein production led to understanding bacterial genome organizationnohttps://cassyni.com/events/AhWU3x7LH7tnmKdE7UxN13?videoPreview=12025-10-27T14:00:00+00:003669.56Night Science InstituteMany features of bacteria such as *E. coli* can be understood by assuming that natural selection tuned them to grow as fast as possible under limited resources. Starting from this insight, we developed a detailed biochemical model of protein synthesis and asked: what is the best way for a cell to allocate its resources among the components of the protein-making machinery? The model predicted that the optimal composition shifts strongly with growth rate – a prediction confirmed by experimental data. We then realized that this growth rate-dependence is supported by the chromosomal positions of the genes encoding the machinery, which are arranged to maximize their availability when needed. This led us to a bigger question: could the locations of all bacterial genes be shaped by such constraints? Strikingly, we found that most bacterial gene families show a bias toward specific chromosomal positions, suggesting a general principle linking genome organization to growth optimization.https://cassyni-user-files-prod.s3.amazonaws.com/TJqJzc623DMqnxYzo6WxM4 https://cassyni.com/events/2Kdix9EkL8TYxmjkYX6MCh/abstract https://cassyni-user-files-prod.s3.amazonaws.com/6Tp7oSuAyzK5HeSC6Z2LBg https://cassyni.com/slides/outline/G8e7ZUE779ysABsTiPx9zV https://cassyni.com/events/G8e7ZUE779ysABsTiPx9zV/abstract https://cassyni-user-files-prod.s3.amazonaws.com/JANDcyKTWukninSzr2By4J https://cassyni.com/events/G8e7ZUE779ysABsTiPx9zV?videoPreview=1 Carbon-Reduction Strategies and their Impact on System Resiliencenohttps://cassyni.com/events/G8e7ZUE779ysABsTiPx9zV?videoPreview=12022-01-13T09:00:00+00:003517.4 School of Public PolicyA framework has been developed for identifying and scaling promising climate solutions that are tailor-made for the unique economic, social and natural resources of sub-national entities including regions and metropolitan areas. This framework and its contribution to system resilience, are illustrated by an application to the Southeastern United States. The framework considers the magnitude of carbon reduction opportunities, the net present value associated with implementing them, and gives preference to those that advance equity, promote economic development, improve public health and nurture the larger environment. Optimization involves minimizing net greenhouse gas emissions, by considering both carbon abatement and carbon sinks. Solutions span electricity, transportation, buildings and industry, as well as agriculture, food, and forests, and they are integral to creating resilient future systems. https://cassyni-user-files-prod.s3.amazonaws.com/JANDcyKTWukninSzr2By4J https://cassyni.com/slides/outline/BCA56dkriaSqm6A7hvFAGM https://cassyni.com/events/BCA56dkriaSqm6A7hvFAGM/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Gt67pgTVcjL2thY4HyPZ58 https://cassyni.com/events/BCA56dkriaSqm6A7hvFAGM?videoPreview=1 Challenging Bioethics Issues and Public Policy: WSCS 2015 Panelnohttps://cassyni.com/events/BCA56dkriaSqm6A7hvFAGM?videoPreview=12015-12-10T09:00:00+00:002505.56 School of Public PolicyThis seminar panel critically examined contemporary bioethical challenges and public policy issues at the intersection of biomedical research, patient advocacy, and regulatory frameworks. A primary focus was the proliferation of “right to try” laws enacted in nearly half of U.S. states, which aim to grant patients access to experimental therapies post-phase one trials. Analysis revealed these laws largely provide symbolic rights without mandating manufacturer compliance, thus offering limited practical effect and raising concerns about exploitation by unregulated stem cell clinics operating in legal gray zones. The discussion highlighted the complex regulatory landscape involving federal FDA oversight versus state legislation, emphasizing the need for enhanced transparency and patient-driven data sharing to mitigate risks posed by unproven therapies. The panel also addressed the contentious use of fetal tissue in research, underscoring its critical role in advancing treatments for neurological and infectious diseases despite political controversies fueled by misleading media portrayals. Legal safeguards separating pregnancy termination decisions from tissue donation, alongside strict reimbursement policies, were affirmed, yet ongoing legislative threats persist in several states. The dialogue stressed the importance of clear, coordinated public education to counter misinformation and foster informed discourse, acknowledging the challenges posed by deeply polarized views. Drawing lessons from historical debates on cloning and embryonic stem cells, the panel advocated for cautious, evidence-based policy development that allows scientific progress while safeguarding ethical standards. Overall, the seminar underscored the necessity of nuanced, multi-level strategies integrating regulation, education, and patient engagement to navigate evolving bioethical landscapes.https://cassyni-user-files-prod.s3.amazonaws.com/Gt67pgTVcjL2thY4HyPZ58 https://cassyni.com/slides/outline/MZoPBcrmLYzzS59f1b8VaV https://cassyni.com/events/MZoPBcrmLYzzS59f1b8VaV/abstract https://cassyni-user-files-prod.s3.amazonaws.com/5BPimeZTLFsjsmu6x3ZM1G https://cassyni.com/events/MZoPBcrmLYzzS59f1b8VaV?videoPreview=1 Challenges and Successes of a Implementing a Required Longitudinal Service Learning Course at Albert Einstein College of Medicinenohttps://cassyni.com/events/MZoPBcrmLYzzS59f1b8VaV?videoPreview=12024-02-28T09:00:00+00:003486.8AAMCService learning is used in medical education to foster community partnerships, prepare students to care for underserved communities, and deepen the understanding of how social and structural determinants of health can be addressed. The Liaison Committee on Medical Education (LCME) recommends that medical schools provide “sufficient opportunities for, encourage, and support medical student participation in S-L and community service activities;" however, implementation varies among institutions, ranging from extracurricular programs and electives to formal curricula. We will present our experience implementing a required 4-year longitudinal service-learning course at Albert Einstein College of Medicine, including our challenges and successes as they relate to establishing community partnerships, curriculum development, and learner assessment. We will include perspectives from students, community partners, educational leadership, and our service-learning team. Participants will leave with ideas for implementation at their own institutions and opportunities for future collaboration and networking. This webinar is part of the Building Better Curriculum Series, hosted by the AAMC. For more information on the complete series, see the [series webpage](https://www.aamc.org/about-us/mission-areas/medical-education/curriculum-resources/establish-your-ci/webinars).  https://cassyni-user-files-prod.s3.amazonaws.com/5BPimeZTLFsjsmu6x3ZM1G https://cassyni.com/events/K6az4q92YdAEDuxLiJmdiM/seminar/qa https://cassyni.com/slides/outline/K6az4q92YdAEDuxLiJmdiM https://cassyni.com/events/K6az4q92YdAEDuxLiJmdiM/abstract https://cassyni-user-files-prod.s3.amazonaws.com/4xiTbSo3r7t72hLnRASPUr https://cassyni.com/events/K6az4q92YdAEDuxLiJmdiM?videoPreview=1 REACH Casual Friday: Change Managementnohttps://cassyni.com/events/K6az4q92YdAEDuxLiJmdiM?videoPreview=12026-03-27T17:00:00+00:002161.04Research Evaluation and Analytics Capacity Hub## This month's Casual Friday Topic: Change Management In an era of constant transformation, your most valuable skill is your ability to adapt. Join us in this coffee talk to discuss components of a Personal Resilience Toolkit, where you’ll learn to navigate the emotional 'change curve' and turn workplace changes into opportunities for growth and high-impact contribution regardless of the position you hold within your organization. https://cassyni-user-files-prod.s3.amazonaws.com/4xiTbSo3r7t72hLnRASPUr https://cassyni.com/slides/outline/J7G9rqL6GM8MQNr6MvkY3f https://cassyni.com/events/J7G9rqL6GM8MQNr6MvkY3f/abstract https://cassyni-user-files-prod.s3.amazonaws.com/4s6nZS12zdNc3giyabSEox https://cassyni.com/events/J7G9rqL6GM8MQNr6MvkY3f?videoPreview=1 Responsible research and innovation at the interfaces AI & Engineering Biologynohttps://cassyni.com/events/J7G9rqL6GM8MQNr6MvkY3f?videoPreview=12022-03-24T09:00:00+00:001495.08 School of Public PolicyThe convergence of artificial intelligence (AI) and engineering biology presents significant opportunities alongside complex challenges, necessitating frameworks for responsible research and innovation (RRI). This analysis contextualizes the interface of AI and synthetic biology by comparing their respective research scales and highlighting ambitious claims, such as accelerated discovery processes, economic impact, and contributions to sustainable development goals. Concurrently, it identifies critical concerns including scientific bias, equity in participation, scalability, intellectual property, data control, security risks, and ethical dilemmas related to algorithmic redesign of living organisms. The discussion situates these issues within established models of technological innovation, such as the Gartner Hype Cycle and Collingridge’s dilemma, emphasizing the tension between rapid technological advancement and slower governance adaptation. Existing codes of ethics from organizations like OECD and the Turing Institute share common principles of wellbeing, justice, and accountability, yet the AI–engineering biology interface may generate novel challenges, particularly regarding pace and complexity. The RRI framework advocated here promotes anticipatory, reflective, and inclusive research practices, integrating stakeholder engagement and iterative assessment throughout the research and development pipeline. Practical applications include public engagement on bio-based menthol production, development of rapid sustainability assessment tools tailored to bio-manufacturing, and embedding responsibility training within doctoral education. The analysis underscores the necessity of interdisciplinary collaboration and ongoing societal dialogue to align technological trajectories with ethical, social, and environmental priorities, fostering a mission-driven bioeconomy that addresses pressing societal needs responsibly.https://cassyni-user-files-prod.s3.amazonaws.com/4s6nZS12zdNc3giyabSEox https://cassyni.com/events/UUuTwpRztKgW5fRUdSFCay/seminar/qa https://cassyni.com/slides/outline/UUuTwpRztKgW5fRUdSFCay https://cassyni.com/events/UUuTwpRztKgW5fRUdSFCay/abstract https://cassyni-user-files-prod.s3.amazonaws.com/ErUY59b8m6XNPzXkvu79wt https://cassyni.com/events/UUuTwpRztKgW5fRUdSFCay?videoPreview=1 22nd international Biometals Webinarsnohttps://cassyni.com/events/UUuTwpRztKgW5fRUdSFCay?videoPreview=12026-01-06T14:00:00+00:005522.76BioMetalsThe 22nd International BioMetals Webinars focused on metal homeostasis, specifically zinc and iron regulation, highlighting their critical roles in biological systems. The first presentation examined metallothioneins (MTs), cysteine-rich proteins essential for zinc buffering and homeostasis. Using biochemical, spectroscopic, and mass spectrometry techniques, the study revealed that human MT isoforms bind zinc with differentiated affinities rather than uniform picomolar affinity, identifying three distinct zinc-binding affinity groups. This polymorphism and metamorphism of MTs enable dynamic zinc buffering across a physiologically relevant range of labile zinc concentrations. Comparative analyses extended to MTs from animals, plants, and bacteria demonstrated conserved differentiated zinc-binding properties, suggesting a broad biological significance. Structural and proteomic approaches mapped zinc-binding sites and elucidated interdomain interactions critical for MT function. The second presentation addressed iron homeostasis in the opportunistic pathogen Pseudomonas aeruginosa, emphasizing the role of iron-regulated small RNAs (PrrF) in controlling iron-dependent metabolism and virulence. Experimental studies using flow-cell biofilms at physiologically relevant temperatures (37°C) demonstrated that PrrF is essential for biofilm formation under low-iron conditions, contrasting with previous findings at 25°C. PrrF-mediated repression of aminobenzoate degradation genes redirects anthranilate toward production of alkylquinolone quorum sensing molecules (AQs), which promote biofilm maturation via autolysis and extracellular DNA release. Additionally, pyochelin, a siderophore previously considered secondary, was shown to be crucial for iron acquisition and biofilm formation at 37°C, compensating for pyoverdine loss. These findings underscore temperature-dependent shifts in iron homeostasis mechanisms relevant to Pseudomonas pathogenicity. Together, these studies advance understanding of metal regulation in diverse biological contexts, with implications for metal-related cellular processes and microbial pathogenesis.https://cassyni-user-files-prod.s3.amazonaws.com/ErUY59b8m6XNPzXkvu79wt https://cassyni.com/slides/outline/UyXSssZdvRJpveg7yTzDzV https://cassyni.com/events/UyXSssZdvRJpveg7yTzDzV/abstract https://cassyni-user-files-prod.s3.amazonaws.com/VC2o66cdcRdk8sqp52sH6W https://cassyni.com/events/UyXSssZdvRJpveg7yTzDzV?videoPreview=1 Bias and Diversity in Data, Software, and Institutionsnohttps://cassyni.com/events/UyXSssZdvRJpveg7yTzDzV?videoPreview=12020-11-20T09:00:00+00:003240.04 School of Public PolicyThis seminar addresses the critical challenges of bias and diversity in data, software, and institutional practices within artificial intelligence (AI) and machine learning (ML). The discussion foregrounds the pervasive impact of biased data—exemplified by medical misdiagnoses due to underrepresentation of darker skin tones—and highlights structural inequities rooted in historical and societal contexts. Emphasis is placed on the composition of decision-making bodies, advocating for broader inclusion of diverse perspectives to mitigate entrenched biases. Techniques such as stakeholder engagement, fairness indicators, and diagnostic tools are proposed to identify and address disparities in datasets and models, though their effectiveness depends on awareness of underlying social dynamics. The seminar also explores institutional barriers, including incentive structures and cultural norms that hinder critical examination of prevailing research paradigms and hiring practices. Notably, the concentration of faculty hiring within a narrow set of elite institutions perpetuates homogeneity, limiting diversity despite a broad pool of interested candidates. Strategies for fostering inclusivity include expanding notions of transferable skills, integrating social scientists into AI teams, and cultivating sponsorship alongside mentorship to support underrepresented groups. The role of leadership in setting priorities and incentives is underscored as essential for systemic change. Resources such as recent scholarship on decolonizing AI and critical technical practices are recommended to deepen engagement. Overall, the seminar elucidates the intertwined nature of technical, social, and institutional factors in addressing bias and diversity, advocating for intentional, multidisciplinary approaches to create equitable AI systems and environments.https://cassyni-user-files-prod.s3.amazonaws.com/VC2o66cdcRdk8sqp52sH6W https://cassyni.com/slides/outline/QXkFgymgn2B5SUfCWtbbch https://cassyni.com/events/QXkFgymgn2B5SUfCWtbbch/abstract https://cassyni-user-files-prod.s3.amazonaws.com/6uFDDa6qo4mxVd8BfuEB1p https://cassyni.com/events/QXkFgymgn2B5SUfCWtbbch?videoPreview=1 Elevated CO₂ gives mature Eucalyptus trees additional resistance and resilience to waterloggingnohttps://cassyni.com/events/QXkFgymgn2B5SUfCWtbbch?videoPreview=12025-08-05T09:00:00+00:00837.2NoneElevated atmospheric CO₂ concentration (eCa), by increasing plant carbon uptake, is thought to ameliorate the negative impacts of stresses on trees. Waterlogging is a severe stress that is potentially harmful to trees, but whether eCa offers trees extra resistance, resilience or both against waterlogging remains unclear. We examined the potential ameliorative effect of eCa against waterlogging at the Eucalyptus Free-Air CO₂ Enrichment (EucFACE) facility, which experienced a 11-month waterlogging. We hypothesised that eCa would reduce the impact of waterlogging on trees by increasing the availability of non-structural carbohydrates (NSC). We tracked the response of trees to waterlogging by measuring tree health, litterfall, photosynthesis, leaf area index (LAI), and NSC. We found that during waterlogging, eCa plots showed higher resistance by having healthier canopies and lower twig litterfall rates. Concurrently, eCa plots had higher LAI and healthy trees in eCa plots had higher sugar fractions in sapwood. We inferred that eCa provided trees with more NSC to resist waterlogging. After the waterlogging event, eCa plots exhibited a faster recovery by having higher leaf production. The higher leaf production was associated with a higher remobilisation of NSC in live bark. In summary, our findings suggest that eCa can ameliorate the negative impact of waterlogging and give trees additional resistance and resilience.https://cassyni-user-files-prod.s3.amazonaws.com/6uFDDa6qo4mxVd8BfuEB1p https://cassyni.com/events/H82Bzj4pC9sZgSUHxiyyAd/seminar/qa https://cassyni.com/slides/outline/H82Bzj4pC9sZgSUHxiyyAd https://cassyni.com/events/H82Bzj4pC9sZgSUHxiyyAd/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Y1qbKPGw7ufkY3d8Y6zJgE https://cassyni.com/events/H82Bzj4pC9sZgSUHxiyyAd?videoPreview=1 SDG 12: Futures of Food-Rethinking Consumption, Production, and Healthnohttps://cassyni.com/events/H82Bzj4pC9sZgSUHxiyyAd?videoPreview=12025-11-20T09:00:00+00:003665.92Springer Nature Sustainable Development Goals ProgrammeHow can we transform the way we produce, consume, and safeguard food to meet the urgent challenges of sustainability, equity, and health? This webinar brings together leading experts to explore the future of food systems through the lens of SDG 12: Responsible Consumption and Production. **Dr. Guoxun Chen** (Huazhong Agricultural University) will examine the nutritional and health dimensions of food consumption, highlighting how dietary choices intersect with sustainable production and long-term wellbeing. **Dr. Veronica Lattanzio** (National Research Council of Italy - EU Food Safety Forum) will discuss analytical approaches to food quality and authenticity, showing how science and policy can work together to reduce waste, protect consumers, and strengthen resilient food systems. **Dr Raveendra Patil** (University of Agricultural Sciences, Dharwad, India) will discuss food literacy, access and justice in the context of India and the global South. Together, the speakers will map out pathways for rethinking food systems that are not only more sustainable and resource-efficient, but also healthier and more just. The session will invite participants to reflect on how interdisciplinary research and practice can accelerate progress towards SDG 12, while shaping the future of food for generations to come. This webinar is part of the ongoing SDG Talks series curated by the SDG 12 Working Group, under the overarching theme “Sustainable Industries for SDG 12.” The series highlights critical dimensions of sustainable practices across diverse sectors, showing innovative approaches to responsible production, consumption, and systemic transformation.https://cassyni-user-files-prod.s3.amazonaws.com/Y1qbKPGw7ufkY3d8Y6zJgE https://cassyni.com/slides/outline/TzEEnWGb3WCgFtr7sVWuBb https://cassyni.com/events/TzEEnWGb3WCgFtr7sVWuBb/abstract https://cassyni-user-files-prod.s3.amazonaws.com/S6ymYppbsKBBMvWaoXNiUN https://cassyni.com/events/TzEEnWGb3WCgFtr7sVWuBb?videoPreview=1 Panel: The Internet of Things, A new Frontier for Seniors and Persons with Disabilitiesnohttps://cassyni.com/events/TzEEnWGb3WCgFtr7sVWuBb?videoPreview=12015-06-24T08:00:00+00:003235.96 School of Public PolicyThe Internet of Things (IoT) presents a transformative frontier for enhancing inclusion and independence among seniors and persons with disabilities, offering unprecedented opportunities in mobility, healthcare, and daily living. This panel discussion explores the multifaceted potential and challenges of IoT through perspectives from industry, academia, and advocacy. Key opportunities include leveraging IoT-enabled ride-sharing platforms to increase transportation accessibility and economic participation, and deploying in-home sensor networks to monitor health status and optimize medical treatments. The discussion emphasizes the critical importance of intelligent integration and interoperability of connected devices to ensure usability and network reliability. Significant concerns address privacy, data ownership, and the risk of information overload, highlighting the need for robust standards and user-centered design. Standards development is identified as essential for enabling secure, efficient, and accessible IoT ecosystems, with ongoing efforts to consolidate protocols and facilitate remote device management. User interfaces must accommodate diverse abilities, incorporating universal design principles and continuous user engagement from early development stages to ensure accessibility and acceptance. Affordability remains a central challenge, necessitating inclusive design and scalable solutions to serve individuals on limited incomes. The panel underscores that the successful realization of IoT’s benefits depends on harmonizing technological innovation with human factors, regulatory frameworks, and active involvement of persons with disabilities throughout the design and standardization processes. This integrated approach promises to advance IoT as a catalyst for social inclusion and improved quality of life.https://cassyni-user-files-prod.s3.amazonaws.com/S6ymYppbsKBBMvWaoXNiUN https://cassyni.com/slides/outline/GdKLinPWwyTgyeryWW58Ah https://cassyni.com/events/GdKLinPWwyTgyeryWW58Ah/abstract https://cassyni-user-files-prod.s3.amazonaws.com/MxjrJtyShBS79kJ3SAoZ4J https://cassyni.com/events/GdKLinPWwyTgyeryWW58Ah?videoPreview=1 Kinetic and Two-Temperature Physics of Black Hole Accretion Disks and X-ray Coronaenohttps://cassyni.com/events/GdKLinPWwyTgyeryWW58Ah?videoPreview=12023-11-09T06:00:00+00:002823.36Journal of Plasma PhysicsUnderstanding the plasma physics of accretion disks and coronae around black holes is crucial for interpreting the radiation observed from these systems. However, these plasmas span several different physical regimes. They can be highly collisional and well-described by a single temperature, or collisionless with nonthermal particles that have been accelerated to high energies. My work brings small-scale kinetic and two-temperature physics into the global setting of the accretion disk/corona system. I first use particle-in-cell (PIC) simulations to understand turbulence and particle acceleration in a collisionless, magnetized plasma. Next, I build an analytic model using prescriptions from PIC simulations to demonstrate an observable power-law from within the plunging region of a black hole. Finally, I use general relativistic magnetohydrodynamic (GRMHD) simulations to examine the impact of two-temperature physics on the radial structure of the full accretion disk. https://cassyni-user-files-prod.s3.amazonaws.com/MxjrJtyShBS79kJ3SAoZ4J https://cassyni.com/events/S1fSiQCNh2v1iiwv5kLZs3/abstract https://cassyni-user-files-prod.s3.amazonaws.com/WFVa5cuCBTQHZ4JZnvBRyG https://cassyni.com/slides/outline/5GS4mh2LFoekajVdodRDyX https://cassyni.com/events/5GS4mh2LFoekajVdodRDyX/abstract https://cassyni-user-files-prod.s3.amazonaws.com/8VekWZpUAizF8hTgmxna6a https://cassyni.com/events/5GS4mh2LFoekajVdodRDyX?videoPreview=1 Effects of the Pandemic on the Developing Childnohttps://cassyni.com/events/5GS4mh2LFoekajVdodRDyX?videoPreview=12021-04-19T06:00:00+00:003767.56Part of the nonprofit Annual Reviews organizationOver the past year, children have dealt with social distancing, Zoom school and family stress. The lucky ones suffered mainly boredom and loneliness; others faced illness, family poverty and hunger, loss of education, or unsafe conditions and abuse. Researchers have observed more depression, suicide and obsessive-compulsive symptoms in children. How will the year of Covid-19 affect their growth, development and futures? There’s reason for hope: Research on past disasters suggests many kids rebound. Two leading child development experts will discuss the ongoing fallout and their visions for what’s ahead. How can parents understand if their kids’ behavior is “normal” when little is normal right now? Who’s most at risk, and how can they be protected? How can parents support their children — and themselves? If kids fall behind on developmental milestones or school, will they be able to catch up?https://cassyni-user-files-prod.s3.amazonaws.com/8VekWZpUAizF8hTgmxna6a https://cassyni.com/events/NZBTcshURYtQu1B9mJow4y/seminar/qa https://cassyni.com/slides/outline/NZBTcshURYtQu1B9mJow4y https://cassyni.com/events/NZBTcshURYtQu1B9mJow4y/abstract https://cassyni-user-files-prod.s3.amazonaws.com/XxEDdb3AzaCxYrWBLvr1kA https://cassyni.com/events/NZBTcshURYtQu1B9mJow4y?videoPreview=1 The new Arctic - A look on the coastal changes, their consequences, and how to manage them nohttps://cassyni.com/events/NZBTcshURYtQu1B9mJow4y?videoPreview=12025-12-16T13:00:00+00:003501.48Springer Nature Sustainable Development Goals ProgrammeThere are only few places on our planet where climate change and its consequences for humans and the environment are as evident as in the Arctic. The EU project FACE-IT (The Future of Arctic Coastal Ecosystems - Identifying Transitions in fjord systems and adjacent coastal areas) investigated the effects of sea-ice and glacier retreat on Arctic fjord ecosystems, their biological diversity, and the impact on the living conditions of the people who use these fjords. Based on the findings, Simon Jungblut, the project manager of FACE-IT, will present how the biodiversity of the Arctic is changing and becoming increasingly similar to the species communities of temperate regions. He will also explain possible scenarios for the future of the Arctic coastal ecosystems and their connected livelihoods in the face of rapid climate change.https://cassyni-user-files-prod.s3.amazonaws.com/XxEDdb3AzaCxYrWBLvr1kA https://cassyni.com/slides/outline/4H8rgKjHNtYbuyfdhewuAd https://cassyni.com/events/4H8rgKjHNtYbuyfdhewuAd/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Mk37qozTK4QrsSkg15tgjg https://cassyni.com/events/4H8rgKjHNtYbuyfdhewuAd?videoPreview=1 The fluid dynamics of weather and climate forecastingnohttps://cassyni.com/events/4H8rgKjHNtYbuyfdhewuAd?videoPreview=12024-01-25T06:00:00+00:002486.08Leeds Institute for Fluid DynamicsWeather and climate forecasting are demanding computational fluid dynamics (CFD) problems - complex, high-resolution, coupled models that are being tested through repeatedly assimilating new observations to produce forecasts within a narrow operational window, every day of the year. Similarly, climate predictions, for example UKCP18 (the UK Climate Predictions 2018), require vast computers to run the weather models into future climate scenarios to provide advice to citizens, private sector and Governments. In this talk I will describe the process of making a weather and climate forecast, and how consistent investment in CFD has led to a consistent improvement in predictive capability. We shall also explore some of the remaining challenges, such as the representation of the moist convection that yields powerful tropical thunderstorms, and then scales up to affecting our weather in the mid latitudes, or the 2d turbulence in the ocean that is so important for the overall ocean circulation, and then the carbon cycle, so important for climate. Finally, I shall introduce some very recent results from AI deep learning emulators of weather models, which point to a major disruption in how operational centres produce weather forecasts, and may well disrupt the whole fluid dynamics endeavour!https://cassyni-user-files-prod.s3.amazonaws.com/Mk37qozTK4QrsSkg15tgjg https://cassyni.com/slides/outline/F9Q9hMxq2xj5SFVfKCBb7T https://cassyni.com/events/F9Q9hMxq2xj5SFVfKCBb7T/abstract https://cassyni-user-files-prod.s3.amazonaws.com/MvWH8o972LAjJY7NnM6H9g https://cassyni.com/events/F9Q9hMxq2xj5SFVfKCBb7T?videoPreview=1 A Physics-Enhanced Approach to Modelling and Monitoring Dynamicsnohttps://cassyni.com/events/F9Q9hMxq2xj5SFVfKCBb7T?videoPreview=12025-09-15T07:00:00+00:003045.0ArtIStE - Artificial Intelligence in Structural EngineeringModern engineering systems face complex, nonlinear, and dynamic conditions that challenge traditional modeling and monitoring approaches. While advances in sensing technologies have enabled detailed data collection, these datasets are often sparse, noisy, and distorted by environmental and operational factors. As a result, purely data-driven methods often struggle to effectively capture system behavior. This talk presents a physics-enhanced digital twin framework that combines physics-based understanding - particularly of system dynamics - with advanced data assimilation techniques. By integrating domain knowledge with observational data, these augmented twins provide interpretable, robust, and scalable solutions for system management. Such a hybrid approach overcomes key limitations of traditional methods and supports improved decision-making for complex, real-world systems. The presentation underscores how embedding physical principles into digital models enables more resilient, aware and responsive engineering infrastructure.https://cassyni-user-files-prod.s3.amazonaws.com/MvWH8o972LAjJY7NnM6H9g https://cassyni.com/events/9iGWBqr4Cve13PFRiHBo81/abstract https://cassyni-user-files-prod.s3.amazonaws.com/4DmtGhdBuwLhkmb5ZejJFp https://cassyni.com/events/SWLfsiMnXrPqYBwRsrTY3F/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Fxqc7arA43SEveey5NCurn https://cassyni.com/events/SWLfsiMnXrPqYBwRsrTY3F?videoPreview=1 Research Integrity in a Post-Truth Era – New Challenges, New Toolsnohttps://cassyni.com/events/SWLfsiMnXrPqYBwRsrTY3F?videoPreview=12026-01-14T08:00:00+00:003573.92Academic Publishing in EuropeIn a landscape of misinformation and AI-generated content, how do we safeguard research integrity? In an era where AI can fabricate research at scale and misinformation moves faster than peer review, the foundation of scientific trust is under unprecedented threat. This high-stakes session confronts the crisis head-on. A leading publisher, a whistleblower, and a policy/industry voice join forces to expose how integrity breaks down – and what it takes to rebuild it. We’ll cut through the noise with real cases, hard truths, and the emerging tools and alliances that can defend science when truth is no longer guaranteed.https://cassyni-user-files-prod.s3.amazonaws.com/Fxqc7arA43SEveey5NCurn https://cassyni.com/slides/outline/SzzGvQ1JyJwtXxUKUHkLJZ https://cassyni.com/events/SzzGvQ1JyJwtXxUKUHkLJZ/abstract https://cassyni-user-files-prod.s3.amazonaws.com/KAv87D3NZtG3VPm3tkUgg6 https://cassyni.com/events/SzzGvQ1JyJwtXxUKUHkLJZ?videoPreview=1 Making AI Work for Global Research Integrity: Using global data and early adoption lessons to guide responsible AI adoption worldwidenohttps://cassyni.com/events/SzzGvQ1JyJwtXxUKUHkLJZ?videoPreview=12026-02-25T14:00:00+00:001384.4Researcher to ReaderNew global data from a forthcoming white paper on the adoption of artificial intelligence (AI) reveals stark regional differences in how researchers view AI’s role in global publishing. This presentation shares original survey findings alongside lessons from Frontiers’ early adoption of AI (AIRA – Artificial Intelligence Review Assistant) for integrity checks and peer review support. Together, these insights provide clear directions for what publishers, funders, and institutions must do next to ensure AI strengthens inclusion, equity and integrity across scholarly communication.https://cassyni-user-files-prod.s3.amazonaws.com/KAv87D3NZtG3VPm3tkUgg6 https://cassyni.com/slides/outline/DAqMdFtcgVSQtn1cZcPvZj https://cassyni.com/events/DAqMdFtcgVSQtn1cZcPvZj/abstract https://cassyni-user-files-prod.s3.amazonaws.com/6R1jPMgGRuG2jTu78zQPeW https://cassyni.com/events/DAqMdFtcgVSQtn1cZcPvZj?videoPreview=1 Using AI with Data and Scholarshipnohttps://cassyni.com/events/DAqMdFtcgVSQtn1cZcPvZj?videoPreview=12025-09-18T06:00:00+00:003358.44AAMCExplore how AI can enhance your research in medical education, from data analysis and literature reviews to writing and visualizing findings. Learn practical strategies for ethical, transparent, and responsible use of AI in scholarship, whether you're new to these tools or looking to expand your toolkit. This webinar is part of the AI Skill Building for Medical Educators Webinar Series, hosted by the AAMC. For more information, see [the complete series webpage](https://www.aamc.org/learn-network/affinity-groups/group-educational-affairs/webinar-series-ai-skill-building-medical-educators).   CME Information - View the last page of the slide deck for complete instructions on earning CME credit for this recording - CME credit for this learning opportunity is organized by Michigan State University College of Human Medicine Office of Continuing Medical Education - You will be prompted to create an account to obtain credithttps://cassyni-user-files-prod.s3.amazonaws.com/6R1jPMgGRuG2jTu78zQPeW https://cassyni.com/slides/outline/YS9YYYdyChxjkXBBGsaJCu https://cassyni.com/events/YS9YYYdyChxjkXBBGsaJCu/abstract https://cassyni-user-files-prod.s3.amazonaws.com/RkPRkENGy2SnsZxrXexgSJ https://cassyni.com/events/YS9YYYdyChxjkXBBGsaJCu?videoPreview=1 The First Phase Diagram for the Dissipation of Astrophysical Plasma Turbulencenohttps://cassyni.com/events/YS9YYYdyChxjkXBBGsaJCu?videoPreview=12026-02-05T16:00:00+00:003604.88Journal of Plasma PhysicsA long-standing problem in heliophysics and astrophysics is to identify the physical mechanisms responsible for the removal of energy from turbulent plasmas under weakly collisional conditions and to quantify the resulting energization of the plasma species, either as plasma heat or particle acceleration. A major goal is to construct predictive models of the turbulent heating in terms of the fundamental plasma and turbulence parameters, quantifying the partitioning of dissipated turbulent energy between the ion and electron species and between the perpendicular and parallel degrees of freedom for each species. Here we present the theoretical framework needed to create the first phase diagram for the dissipation of plasma turbulence in terms of the fundamental, dimensionless parameters that characterize the system. A set of ten general plasma and turbulence parameters are defined, and reasonable approximations along with the exploitation of existing scaling theories for magnetohydrodynamic turbulence are used to reduce this general set of ten parameters to just three parameters in the isotropic temperature case: the ion plasma beta, the ion-to-electron temperature ratio, and the isotropic driving wavenumber. Analytical estimations of the scaling of each proposed damping mechanism on these fundamental parameters are used to develop the first phase diagram for the turbulent damping mechanisms as a function of the ion plasma beta and isotropic driving wavenumber for unity ion-to-electron temperature ratio. I will present an example of how to use this phase diagram to characterize the turbulent damping mechanisms in a kinetic simulation of weakly collisional plasma turbulence. This phase diagram establishes the framework needed to place the variety of numerical and observational results into a consistent context to enable meaningful comparisons.https://cassyni-user-files-prod.s3.amazonaws.com/RkPRkENGy2SnsZxrXexgSJ https://cassyni.com/events/VxuXK8QM1RCFPahcjBffUy/abstract https://cassyni-user-files-prod.s3.amazonaws.com/2CGz1NSW3y7HBCf8FiEKJe https://cassyni.com/slides/outline/R2RUrHw6cqfDzUzGihxfkq https://cassyni.com/events/R2RUrHw6cqfDzUzGihxfkq/abstract https://cassyni-user-files-prod.s3.amazonaws.com/6ufLS3KnsMp8QTCDeXavC6 https://cassyni.com/events/R2RUrHw6cqfDzUzGihxfkq?videoPreview=1 AI for Assessment and Evaluation in Medical Educationnohttps://cassyni.com/events/R2RUrHw6cqfDzUzGihxfkq?videoPreview=12025-12-18T14:00:00+00:003640.32AAMCObjectives - Understand the rationale and opportunities for AI-assessment and evaluation - Construct a reliable assessment tool using an application programming interface (API) - Reflect on considerations for sound and reliable AI-assessment approaches This webinar is part of the AI Skill Building for Medical Educators Webinar Series, hosted by the AAMC. For more information, see [the complete series webpage](https://www.aamc.org/learn-network/affinity-groups/group-educational-affairs/webinar-series-ai-skill-building-medical-educators).   CME Information - View the last page of the slide deck for complete instructions on earning CME credit for this recording - CME credit for this learning opportunity is organized by Michigan State University College of Human Medicine Office of Continuing Medical Education - You will be prompted to create an account to obtain credithttps://cassyni-user-files-prod.s3.amazonaws.com/6ufLS3KnsMp8QTCDeXavC6 https://cassyni.com/events/Gd1VTrimX1GhNQCZNFkGDs/abstract https://cassyni-user-files-prod.s3.amazonaws.com/MUw4QsvPuW5euCGHniVwR8 https://cassyni.com/events/K6H8ouUH7eyEcMi5cDqSYM/seminar/qa https://cassyni.com/slides/outline/K6H8ouUH7eyEcMi5cDqSYM https://cassyni.com/events/K6H8ouUH7eyEcMi5cDqSYM/abstract https://cassyni-user-files-prod.s3.amazonaws.com/6WQcY1yKSjETwyvYJFNiuC https://cassyni.com/events/K6H8ouUH7eyEcMi5cDqSYM?videoPreview=1 Evaluating and Advancing Large Language Models for Water Knowledge Tasks in Engineering and Researchnohttps://cassyni.com/events/K6H8ouUH7eyEcMi5cDqSYM?videoPreview=12026-02-25T11:00:00+00:003211.84ElsevierAlthough large language models (LLMs) have demonstrated significant value in numerous fields, there remains limited research on evaluating their performance or enhancing their capabilities within water science and technology. This study initially assessed the performance of eight foundational models (i.e., GPT-4, GPT-3.5, Gemini, GLM-4, ERNIE, QWEN, Llama3-8B, and Llama3-70B) on a wide range of water knowledge tasks in engineering and research by developing an evaluation suite called WaterER (i.e., 1043 tasks). GPT-4 was demonstrated to excel in diverse water knowledge tasks in engineering and research. Llama3-70B was best for Chinese engineering queries, while Chinese-oriented models outperformed GPT-3.5 in English engineering tasks. Gemini demonstrated specialized academic capabilities in wastewater treatment, environmental restoration, drinking water treatment, sanitation, anaerobic digestion, and contaminants. To further advance LLMs, we employed prompt engineering (i.e., five-shot learning) and fine-tuned open-sourced Llama3-8B into a specialized model, namely, WaterGPT. WaterGPT exhibited enhanced reasoning capabilities, outperforming Llama3-8B by over 135.4% on English engineering tasks and 18.8% on research tasks. Additionally, fine-tuning proved to be more reliable and effective than prompt engineering. Collectively, this study established various LLMs’ baseline performance in water sectors while highlighting the robust evaluation frameworks and augmentation techniques to ensure the effective and reliable use of LLMs.https://cassyni-user-files-prod.s3.amazonaws.com/6WQcY1yKSjETwyvYJFNiuC https://cassyni.com/events/S1MbTUXdG4j27AheyfQNh3/seminar/qa https://cassyni.com/slides/outline/S1MbTUXdG4j27AheyfQNh3 https://cassyni.com/events/S1MbTUXdG4j27AheyfQNh3/abstract https://cassyni-user-files-prod.s3.amazonaws.com/8H17SzZx5wvLSA8w3EWhiW https://cassyni.com/events/S1MbTUXdG4j27AheyfQNh3?videoPreview=1 Special Issue Launch: Supporting Mental Health & Wellbeing of Practitioners in Trainingnohttps://cassyni.com/events/S1MbTUXdG4j27AheyfQNh3?videoPreview=12026-05-14T17:00:00+00:002962.0MultiPsych JournalThis special issue welcomes guest editors Dr Sofie Bager-Charleson and Dr Craig Abex who will introduce the latest call for papers concerned with supporting the mental health and wellbeing of all practitioners in training. We will explore the importance of relational ethics, supervision, social justice, systemic and racial injustice and how we can support trainee mental health and wellbeing in the midst of the growing pressures across the mutlidisciplinary training programmes of psychology, psychiatry, neuroscience and psychotherapy. We consider the vital topics of lowering suicide rates and improving the mental health and wellbeing of a diverse range of trainees embarking on an international array of highly demanding training programmes. We look forward to calling for papers in these important areas of research.https://cassyni-user-files-prod.s3.amazonaws.com/8H17SzZx5wvLSA8w3EWhiW https://cassyni.com/events/5G8DWmMapqTkyBFNhYV2oX/seminar/qa https://cassyni.com/slides/outline/5G8DWmMapqTkyBFNhYV2oX https://cassyni.com/events/5G8DWmMapqTkyBFNhYV2oX/abstract https://cassyni-user-files-prod.s3.amazonaws.com/4pX1NLNmYTUj6F2XW8t95G https://cassyni.com/events/5G8DWmMapqTkyBFNhYV2oX?videoPreview=1 Future water demand modeling: A multi-sector review using a streamlined methodological approachnohttps://cassyni.com/events/5G8DWmMapqTkyBFNhYV2oX?videoPreview=12026-03-17T15:00:00+00:001707.4Cambridge PrismsFuture water demand modeling is of crucial importance for stakeholders, particularly in the era of rapidly changing climate and socioeconomic conditions. The modeling results can be applied to develop effective adaptation strategies that ensure equitable and sustainable allocation of water to various economic sectors, including institutional, commercial, industrial (ICI), residential and agricultural. However, a comprehensive review of existing future water demand modeling methods that consider both climatic and socioeconomic factors as well as the major economic sectors is currently lacking. This review article contributes to fill this knowledge gap while introducing a more streamlined and comprehensive methodological approach for conducting literature reviews in the environmental sciences domain. At the core of this method is a new framework designed to support research questions formulation and literature search strategies named STAR (Systems, Trouble/Treatment, Alternative, Response). In addition, it presents a data-requirement-based metric as well as a new nomenclature for classification of surveyed methods and approaches to guide the selection process of future water demand modeling methods. Furthermore, it proposes a hybrid modeling approach made up of three components (computational intelligence, dynamic systems and probabilistic scenarios) in the form of a theoretical workflow for future water demand modeling. The proposed workflow ensures broad applicability, making it adaptable not only to water demand management but also to a wide range of challenges across the environmental sciences.https://cassyni-user-files-prod.s3.amazonaws.com/4pX1NLNmYTUj6F2XW8t95G https://cassyni.com/slides/outline/4mWEaiDwnjqS7tQtPg8gAq https://cassyni.com/events/4mWEaiDwnjqS7tQtPg8gAq/abstract https://cassyni-user-files-prod.s3.amazonaws.com/WJLf7DAhyVfhiZzNdR8HGa https://cassyni.com/events/4mWEaiDwnjqS7tQtPg8gAq?videoPreview=1 Nanorobots for Biomedical and Environmental Applicationsnohttps://cassyni.com/events/4mWEaiDwnjqS7tQtPg8gAq?videoPreview=12026-05-20T09:00:00+00:002532.44Connecting Science, Publishing, and InnovationNanorobotics represent a groundbreaking advancement in the fight against environmental pollution and health challenges. These nanoscale devices are engineered to target critical issues such as the removal of nanoplastics from aquatic environments and the eradication of resilient biofilms that compromise medical treatments and device performance. Leveraging their precise atomic-scale designs, single-atom nanorobots disrupt biofilm structures to enhance therapeutic outcomes and adsorb micro- and nanoplastics to mitigate water pollution. This discussion explores the innovative architectures and mechanisms of single-atom nanorobots, emphasizing their potential to revolutionize biomedical and environmental fields. Key advancements include their role in delivering highly targeted therapies, boosting antibiotic efficiency, and capturing harmful plastic particles from ecosystems. The paper provides an in-depth analysis of their current capabilities, emerging applications, and the challenges of scaling these technologies for sustainable global impact. https://cassyni-user-files-prod.s3.amazonaws.com/WJLf7DAhyVfhiZzNdR8HGa https://cassyni.com/slides/outline/NYscMx2izahRHSvtfDsjty https://cassyni.com/events/NYscMx2izahRHSvtfDsjty/abstract https://cassyni-user-files-prod.s3.amazonaws.com/SkrGrtvQRhJAWFttTN73W6 https://cassyni.com/events/NYscMx2izahRHSvtfDsjty?videoPreview=1 SSP Innovation Showcase (Spring 2026) nohttps://cassyni.com/events/NYscMx2izahRHSvtfDsjty?videoPreview=12026-03-30T08:00:00+00:003642.72SSP Society for Scholarly PublishingThis free webinar showcased new developments and innovations shaping our industry. Participating companies included: Cashmere, ManuCheck, Vertex, and Cassyni. https://cassyni-user-files-prod.s3.amazonaws.com/SkrGrtvQRhJAWFttTN73W6 https://cassyni.com/events/PYCSZwqfGrjJ6z391btqZf/seminar/qa https://cassyni.com/slides/outline/PYCSZwqfGrjJ6z391btqZf https://cassyni.com/events/PYCSZwqfGrjJ6z391btqZf/abstract https://cassyni-user-files-prod.s3.amazonaws.com/KnLA7LZCdh9mawdyJCU99g https://cassyni.com/events/PYCSZwqfGrjJ6z391btqZf?videoPreview=1 Nektar++ updates and future developmentsnohttps://cassyni.com/events/PYCSZwqfGrjJ6z391btqZf?videoPreview=12026-06-08T12:00:00+00:007294.96Nektar++ Development TeamNektar++, an open-source spectral/hp element framework, is undergoing significant updates to enhance its performance on modern computing architectures and streamline community engagement. A new code architecture introduces "blocks of storage" and specialized operators for CPU, GPU, and AVX units, leveraging techniques such as vectorized sum factorization and threaded-on-output-point sum factorization for optimal performance. Benchmarks of the Helmholtz operator demonstrate a 5.5x speedup on CPUs with AVX-512 and up to a 10x speedup on A100 GPUs compared to legacy implementations. A redesigned compressible flow solver achieved a 3.2x speedup from architectural rewrites, increasing to 5.3x with AVX, while an incompressible Navier-Stokes solver showed a 6x speedup on a single GPU compared to 56 CPUs. For improved scalability on high-performance computing systems, HDF5 output formats for meshes and fields are being adopted as the default, replacing less efficient XML-based I/O. Community infrastructure is bolstered by a new collaborative online publications list and a dedicated forum for discussions, replacing the deprecated mailing list. Additionally, interactive Jupyter tutorials are now accessible via pre-configured VirtualBox images, simplifying user onboarding. Future directions include participation in the Remodel grant, focusing on in-simulation mesh adaptivity to dynamically adjust polynomial order, move mesh points, and refine meshes. These advancements aim to solidify Nektar++'s position as a robust tool for scientific and engineering simulations, fostering continued development and broader adoption.https://cassyni-user-files-prod.s3.amazonaws.com/KnLA7LZCdh9mawdyJCU99g https://cassyni.com/events/VTtpnG4JLGbf8s1DdKnLDs/abstract https://cassyni-user-files-prod.s3.amazonaws.com/HfXHcVfkVJCLo9fFVHcCGv https://cassyni.com/slides/outline/UUbcgtmFTMVWU7BDXMK1Qy https://cassyni.com/events/UUbcgtmFTMVWU7BDXMK1Qy/abstract https://cassyni-user-files-prod.s3.amazonaws.com/BSWDaEwYd7ctYzj7iKqhw4 https://cassyni.com/events/UUbcgtmFTMVWU7BDXMK1Qy?videoPreview=1 Welcome & Agendanohttps://cassyni.com/events/UUbcgtmFTMVWU7BDXMK1Qy?videoPreview=12026-02-24T09:30:00+00:00605.64Researcher to ReaderThe Conference Chairman welcomes the participants, thanks the sponsors, introduces the programme and makes feeble jokes.https://cassyni-user-files-prod.s3.amazonaws.com/BSWDaEwYd7ctYzj7iKqhw4 https://cassyni.com/slides/outline/EeShPkeZAXz2pviWcfxbg9 https://cassyni.com/events/EeShPkeZAXz2pviWcfxbg9/abstract https://cassyni-user-files-prod.s3.amazonaws.com/SvAZFKJV66oaEwG8JBrnva https://cassyni.com/events/EeShPkeZAXz2pviWcfxbg9?videoPreview=1 HCR • Using AI to support Precision Medicine and Precision Public Health Policy in Diabetesnohttps://cassyni.com/events/EeShPkeZAXz2pviWcfxbg9?videoPreview=12025-08-29T01:00:00+00:004643.52NoneTo further advance academic exchanges and cooperation in global healthcare and rehabilitation, the journal [Healthcare and Rehabilitation (HCR)](https://www.keaipublishing.com/en/journals/healthcare-and-rehabilitation/) is pleased to launch the “Qilu International Academic Lecture on Healthcare and Rehabilitation”. This lecture series aims to build an interdisciplinary, high-quality international exchange platform that brings together top experts and young scholars from around the world to explore the latest research trends and cutting-edge topics in the field. On August 29, 2025, Dr. Hui Shao, Associate Professor at Emory University’s Rollins School of Public Health, delivered a report titled "Using Artificial Intelligence to Support Precision Medicine and Precision Public Health Policy in Diabetes". https://cassyni-user-files-prod.s3.amazonaws.com/SvAZFKJV66oaEwG8JBrnva https://cassyni.com/slides/outline/F96JSSJ5bzY5phFQD7FPwT https://cassyni.com/events/F96JSSJ5bzY5phFQD7FPwT/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Hi7bKP7mZpF2io8yEyYdev https://cassyni.com/events/F96JSSJ5bzY5phFQD7FPwT?videoPreview=1 Visualizing and Addressing Health-Related Social Needs (HRSN)nohttps://cassyni.com/events/F96JSSJ5bzY5phFQD7FPwT?videoPreview=12026-04-02T20:00:00+00:003566.52Family Medicine_Please note that Dr. Chuck Eaton will present in lieu of Dr. Joseph Diaz._ Objectives: 1) Describe the purpose and process of developing the first version of a Care New England system-wide, community-facing HRSN dashboard 2) Discuss preliminary analysis regarding the association between HRSN and breast/colon cancer screening adherence 3) Discuss two pilot programs currently being deployed to address social needs within Care New England 4) Critique the current data visualization tools to inform future dashboard iterationshttps://cassyni-user-files-prod.s3.amazonaws.com/Hi7bKP7mZpF2io8yEyYdev https://cassyni.com/slides/outline/N4CPCdsK9mDbTywNs7kmim https://cassyni.com/events/N4CPCdsK9mDbTywNs7kmim/abstract https://cassyni-user-files-prod.s3.amazonaws.com/8JgTCoKiKB1fXS8AdYy6ut https://cassyni.com/events/N4CPCdsK9mDbTywNs7kmim?videoPreview=1 Kriyadocs: Designing Peer Review Around Researchers (Lightning Talk)nohttps://cassyni.com/events/N4CPCdsK9mDbTywNs7kmim?videoPreview=12026-02-25T13:00:00+00:00465.64Researcher to ReaderJournals need to improve user experience for researchers whilst handling increasing volumes of submissions; working at sufficient speed to meet researcher expectations; and maintaining research integrity. In this talk, we share how Kriyadocs works with scholarly publishers and industry experts to deliver a modern, flexible, robust solution for peer review.https://cassyni-user-files-prod.s3.amazonaws.com/8JgTCoKiKB1fXS8AdYy6ut https://cassyni.com/slides/outline/QXSQS46wM3z5pvQwQofQSh https://cassyni.com/events/QXSQS46wM3z5pvQwQofQSh/abstract https://cassyni-user-files-prod.s3.amazonaws.com/A7nt9x3SDoeSTbS6mpU21L https://cassyni.com/events/QXSQS46wM3z5pvQwQofQSh?videoPreview=1 A5 – Critical and Emerging Technologies: Strategic Planning and Partnershipsnohttps://cassyni.com/events/QXSQS46wM3z5pvQwQofQSh?videoPreview=12026-04-20T10:00:00+00:001909.2Research Analytics SummitGovernments and research funders increasingly prioritize critical and emerging technologies—including artificial intelligence, biotechnology, nuclear technologies, quantum information science, and semiconductors—to maintain competitiveness and address global challenges. These fields require significant investment and complex collaboration across government, industry, and academia, making effective governance and strategic planning essential. In this session, Elsevier will present an analysis of U.S. and global research positions and industry–academic partnerships in these technologies. Using trusted, curated data and advanced analytical tools, this work demonstrates how high-quality evidence is essential for accurately mapping innovation landscapes, informing policy, and enabling secure, strategic research partnerships.https://cassyni-user-files-prod.s3.amazonaws.com/A7nt9x3SDoeSTbS6mpU21L https://cassyni.com/slides/outline/H7iLjoQ4mBga4tE2re3mzd https://cassyni.com/events/H7iLjoQ4mBga4tE2re3mzd/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Sk1WHVNZJEZmeRnUMi895p https://cassyni.com/events/H7iLjoQ4mBga4tE2re3mzd?videoPreview=1 D2 – Streamlining HERD Submissions: Leveraging SQL, Power BI, and Campus Engagement for Reliable Reportingnohttps://cassyni.com/events/H7iLjoQ4mBga4tE2re3mzd?videoPreview=12026-04-20T13:30:00+00:002840.36Research Analytics SummitThe National Science Foundation’s Higher Education Research and Development (HERD) Survey is essential for benchmarking institutional research expenditures and informing strategic decision – making. This session presents the University of Florida’s repeatable approach to calculating and validating institutional data for inclusion in HERD reporting using an integrated SQL and Power BI workflow. The presentation focuses on the design of a centralized HERD reporting pipeline built on SQL Server ledger views and stored procedures that standardize financial data extraction and enforce HERD business rules. These components reduce manual effort, support consistent year – over – year reporting, and enable early identification of data quality issues through recurring SQL – based error checks deployed throughout the fiscal year. Attendees will also see how Power BI dashboards are integrated into the HERD preparation process as active validation tools rather than solely as final reporting outputs. These dashboards surface trends, flag anomalies, and support proactive issue resolution. The session concludes with UF’s HERD reporting roadmap for vending a validated HERD dataset tailored to executive leadership, research administrators, and departmental stakeholders.https://cassyni-user-files-prod.s3.amazonaws.com/Sk1WHVNZJEZmeRnUMi895p https://cassyni.com/slides/outline/KaxMyDdgxUT4RphbQKxQiZ https://cassyni.com/events/KaxMyDdgxUT4RphbQKxQiZ/abstract https://cassyni-user-files-prod.s3.amazonaws.com/4pMTiEuaWWo4wcYxrNNP1G https://cassyni.com/events/KaxMyDdgxUT4RphbQKxQiZ?videoPreview=1 F6 – Small but Mighty: From First Steps to Future Leadership in Research Analyticsnohttps://cassyni.com/events/KaxMyDdgxUT4RphbQKxQiZ?videoPreview=12026-04-21T09:15:00+00:002137.76Research Analytics SummitIn this session, the history, current state, and future goals of Ontario Tech University (OTU) will be discussed by two stakeholders driving an organizational shift towards modernization and establishing a data – driven culture. The session will begin with a broad presentation of key decisions, software, stakeholders, and other factors that brought OTU to the beginning of 2025. Following this will be an interwoven dialogue of the organization’s changes in 2025, including how these changes were selected for their immediate impact as well as their help in future goals. This will include software (eRAS, Romeo; Power BI, SQL/SSMS; Banner; Microsoft & Google Suite), stakeholders (Research Business Analyst; Directors; Finance; HR; Research accounting; and other departments), processes and workarounds, key challenges, supporters, and other factors we have faced on the road to change. The future will describe the hopeful future of OTU including the timeline, data strategy development, planned software upgrades, and AI implementation. At the end of the session, attendees will understand short – and long – term changes, plus their impact, currently being made by a small university aiming to modernize and build a culture driven by data and research.https://cassyni-user-files-prod.s3.amazonaws.com/4pMTiEuaWWo4wcYxrNNP1G https://cassyni.com/slides/outline/5koSg5WzfewaneEtVebzyj https://cassyni.com/events/5koSg5WzfewaneEtVebzyj/abstract https://cassyni-user-files-prod.s3.amazonaws.com/KRc1P683jMb2ThgG7qD8DC https://cassyni.com/events/5koSg5WzfewaneEtVebzyj?videoPreview=1 Palgrave Macmillan Being Human Festivalnohttps://cassyni.com/events/5koSg5WzfewaneEtVebzyj?videoPreview=12019-03-26T06:00:00+00:0092.08NoneThis seminar addressed a diverse and significant range of issues concerning what it means to be human and the evolving concept of "designing humans." Adopting a profoundly interdisciplinary methodology, the discussions synthesized perspectives from science, literature, philosophy, ethics, and history. This comprehensive approach allowed for an examination of complex problems that might otherwise appear disparate, highlighting the unifying capacity of the humanities to bridge diverse fields. A central topic explored was the ethical framework surrounding human reproduction, specifically investigating the moral implications of decisions related to procreating a particular child over another. This analysis engaged with broader themes of human "origins and endings," prompting critical consideration of human agency and intervention in these fundamental life processes. The seminar fostered an interactive environment aimed at generating provocative questions regarding humanity's potential to shape its own future, underscoring the societal and ethical responsibilities inherent in advancements related to human design.https://cassyni-user-files-prod.s3.amazonaws.com/KRc1P683jMb2ThgG7qD8DC https://cassyni.com/slides/outline/FdmXbkTVSp1ueAEv1DNN7f https://cassyni.com/events/FdmXbkTVSp1ueAEv1DNN7f/abstract https://cassyni-user-files-prod.s3.amazonaws.com/P1AbomdpeovBYNgFKLQV8J https://cassyni.com/events/FdmXbkTVSp1ueAEv1DNN7f?videoPreview=1 Opening the Black Box for Biologynohttps://cassyni.com/events/FdmXbkTVSp1ueAEv1DNN7f?videoPreview=12026-04-02T18:00:00+00:003707.36AI Institute in Dynamic SystemsWhat do neural networks learn? In this talk, I will explore ways we can understand deep neural networks and their generalization properties by decomposing them into smaller parts. Under the right conditions, these parts can surprisingly model real physical and biological systems, and in silico perturbation can be used to explore their design space. Motivated by problems in cancer biology, immune engineering, and DNA design, I will discuss how this new approach to mechanistic interpretability is helping us decode the hidden grammar of biology and program health. https://cassyni-user-files-prod.s3.amazonaws.com/P1AbomdpeovBYNgFKLQV8J https://cassyni.com/events/Vxbg4CjbaT1Fn2TMd6jUJy/seminar/qa https://cassyni.com/slides/outline/Vxbg4CjbaT1Fn2TMd6jUJy https://cassyni.com/events/Vxbg4CjbaT1Fn2TMd6jUJy/abstract https://cassyni-user-files-prod.s3.amazonaws.com/9WntxR6uUbqoadCb7N7pv2 https://cassyni.com/events/Vxbg4CjbaT1Fn2TMd6jUJy?videoPreview=1 Reconsidering Proto-Austronesiannohttps://cassyni.com/events/Vxbg4CjbaT1Fn2TMd6jUJy?videoPreview=12026-07-17T04:10:00+00:002982.4Linguistics and Applied Language StudiesA re-examination of the phoneme system of Proto-Austronesian, drawing on the Formosan language data and the reconstructions of the Proto-Austronesian lexicon in *The Austronesian Comparative Dictionary*. It considers the implications of this revised phoneme system for the subgrouping of the Formosan languages and the place of the Malayo-Polynesian languages in relation to that Formosan subgrouping. It proposes a simpler phoneme system than that used in *The Austronesian Comparative Dictionary*, with a coronal rather than a palatal centre of gravity, and a revised subgrouping of the Formosan languages that includes two new primary branches of Austronesian, one that incorporates the East Formosan languages and Bunun, and potentially also the Malayo-Polynesian languages, defined by the merger of proto-t and proto-C as *t*, and one that incorporates Rukai, Puyuma and Paiwan, and potentially also the Malayo-Polynesian languages, defined by the split of proto-k into *k* and *g*. It also proposes two replacement defining innovations for the Atayalic branch, namely the merger of proto-l and proto-N as *l* and the shift of proto-R to *g*, and an additional defining innovation for the Northwest Formosan branch, namely the shift of proto-j to *z*, complementing the already recognized merger of proto-S and proto-C as *s*, which form the voiceless and voiced pair of a spirantization process in Northwest Formosan that affects all affricates.https://cassyni-user-files-prod.s3.amazonaws.com/9WntxR6uUbqoadCb7N7pv2 https://cassyni.com/slides/outline/YRqhHcyDmjmk8xvvAne72u https://cassyni.com/events/YRqhHcyDmjmk8xvvAne72u/abstract https://cassyni-user-files-prod.s3.amazonaws.com/6hpq6bfdDjZNdppFqkuU9t https://cassyni.com/events/YRqhHcyDmjmk8xvvAne72u?videoPreview=1 Authorship Equity: Lessons from Global Health Collaborationnohttps://cassyni.com/events/YRqhHcyDmjmk8xvvAne72u?videoPreview=12026-09-17T20:00:00+00:003276.08Family MedicineLearning Objectives: - Analyze common patterns of authorship inequity in global health research and the factors that contribute to them. - Examine examples of authorship representation and inequity within family medicine and global health collaborations. - Apply strategies to foster equitable authorship and dissemination practices in collaborative research partnerships.https://cassyni-user-files-prod.s3.amazonaws.com/6hpq6bfdDjZNdppFqkuU9t https://cassyni.com/events/R27dbNGMBsUENvk1cd2Uaq/seminar/qa https://cassyni.com/slides/outline/R27dbNGMBsUENvk1cd2Uaq https://cassyni.com/events/R27dbNGMBsUENvk1cd2Uaq/abstract https://cassyni-user-files-prod.s3.amazonaws.com/XBm7ZgySv7k1bo2Z2zEBC2 https://cassyni.com/events/R27dbNGMBsUENvk1cd2Uaq?videoPreview=1 The Illusion of Transparency: Explainability and Safety in Healthcarenohttps://cassyni.com/events/R27dbNGMBsUENvk1cd2Uaq?videoPreview=12026-04-14T16:00:00+00:003138.0School of Data ScienceIn high-stakes clinical environments, the deployment of AI requires more than just high accuracy; it necessitates a foundation of trust built upon explainability and safety. This talk will explore the “Illusion of Transparency,” arguing that trustworthy properties are not emergent features of large-scale frontier models but must be intentionally engineered into the system. https://cassyni-user-files-prod.s3.amazonaws.com/XBm7ZgySv7k1bo2Z2zEBC2 https://cassyni.com/events/TVMepnVyPAEijsDaAJw7Jm/seminar/qa https://cassyni.com/slides/outline/TVMepnVyPAEijsDaAJw7Jm https://cassyni.com/events/TVMepnVyPAEijsDaAJw7Jm/abstract https://cassyni-user-files-prod.s3.amazonaws.com/KVVM8wxhPrz4P9rweGMkLN https://cassyni.com/events/TVMepnVyPAEijsDaAJw7Jm?videoPreview=1 Investigating the Coupling of Bone Morphology and Material Properties in a Paediatric Populationnohttps://cassyni.com/events/TVMepnVyPAEijsDaAJw7Jm?videoPreview=12026-04-28T04:00:00+00:002607.4The Auckland Bioengineering InstituteAccurate modelling of children’s bones is essential for understanding bone mechanics and supporting orthopaedic care. However, creating subject-specific finite element models typically requires full CT scans, which are often avoided in paediatric populations due to radiation exposure. This research develops a new framework to generate personalised bone models of the femur and tibia using limited or even no imaging data. Based on a large cohort of paediatric CT scans (N=330), statistical models were constructed to capture variations in both bone shape and density. These models were then used to predict individual bone structure under different data scenarios, including partial imaging and non-imaging inputs. The results show that incorporating bone density information is critical for accurate biomechanical predictions, and that reliable models can be achieved using only partial imaging. This work provides a practical pathway towards low-radiation, personalised modelling of children’s bones, with potential applications in orthopaedic research and surgical planning.https://cassyni-user-files-prod.s3.amazonaws.com/KVVM8wxhPrz4P9rweGMkLN https://cassyni.com/events/3Hb3ZHoFsj6paBTjEXdotR/abstract https://cassyni-user-files-prod.s3.amazonaws.com/C63py8Su9Jk7NuWCVe6pvi https://cassyni.com/events/ACfWCrrc28rc4zTJbyCk37/seminar/qa https://cassyni.com/slides/outline/ACfWCrrc28rc4zTJbyCk37 https://cassyni.com/events/ACfWCrrc28rc4zTJbyCk37/abstract https://cassyni-user-files-prod.s3.amazonaws.com/DG91rnqQ1zern9Bq3qPdDg https://cassyni.com/events/ACfWCrrc28rc4zTJbyCk37?videoPreview=1 The biophysical basis of intracellular homeostasisnohttps://cassyni.com/events/ACfWCrrc28rc4zTJbyCk37?videoPreview=12026-06-02T04:00:00+00:004260.92The Auckland Bioengineering InstituteCellular physiology operates at the theoretical limits set by physical laws – for example, ion channels are sensitive to the passage of a single elementary charge, and retinae can detect one photon. Eukaryotic cells also exploit every form of energy storage mechanism available – biochemical (e.g., solute concentrations and chemical bonds), electrical (e.g., capacitive charge storage in the cell membrane), mechanical (e.g., the elastic compliance of cellular membranes), and thermal (the heat storage essential for maintaining body temperature). Since cells appear to have evolved to maximally exploit the laws of physics within their particular environmental niche, we should try to explain cell behaviour in the light of those laws. This talk will present an analysis of cell homeostasis using a ‘bond graph’ modelling approach that ensures that the conservation laws of physics (i.e., conservation of mass, charge, and energy, respectively) are satisfied for the interdependent biochemical, electrical, mechanical, and thermal energy storage mechanisms operating within the cell. The bond graph approach is applied to several cell membrane transport mechanisms and then used to consider how physics constrains intracellular electrolyte homeostasis for enterocytes (the epithelial absorptive cells in the lining of the intestinal mucosa). The model includes the electrogenic sodium-potassium ATPase pump (NKA) and an inwardly rectifying potassium channel (Kir) in the basolateral membrane, the electrogenic sodium-driven glucose transporter (SGLT1) in the apical membrane, and the glucose transporter (GLUT2) expressed in both membranes. https://cassyni-user-files-prod.s3.amazonaws.com/DG91rnqQ1zern9Bq3qPdDg https://cassyni.com/events/M4xRLXc35Zxok3ZaTuzCqj/abstract https://cassyni-user-files-prod.s3.amazonaws.com/ScRpz6wRcCVTbzdjj1oTmG https://cassyni.com/events/MZdeVqmSvPSdZWZ6G27B1w/seminar/qa https://cassyni.com/slides/outline/MZdeVqmSvPSdZWZ6G27B1w https://cassyni.com/events/MZdeVqmSvPSdZWZ6G27B1w/abstract https://cassyni-user-files-prod.s3.amazonaws.com/WxFhqiJ1cyc9EUKtQpPZf4 https://cassyni.com/events/MZdeVqmSvPSdZWZ6G27B1w?videoPreview=1 Publishing in Ecology & Evolution: An Editor’s Perspectivenohttps://cassyni.com/events/MZdeVqmSvPSdZWZ6G27B1w?videoPreview=12026-07-02T13:00:00+00:003674.16Ecology and Evolution Stop by to meet Arley Muth, Co-Editor-in-Chief of Ecology and Evolution. Arley will be available to answer your questions about the publication process, the journal, and related topics.https://cassyni-user-files-prod.s3.amazonaws.com/WxFhqiJ1cyc9EUKtQpPZf4 https://cassyni.com/events/AhLjNB21rxLRtm2fMuw3SV/seminar/qa https://cassyni.com/slides/outline/AhLjNB21rxLRtm2fMuw3SV https://cassyni.com/events/AhLjNB21rxLRtm2fMuw3SV/abstract https://cassyni-user-files-prod.s3.amazonaws.com/BtVcTD9dz2iBziC3DbNeVk https://cassyni.com/events/AhLjNB21rxLRtm2fMuw3SV?videoPreview=1 Elucidating the Mechanism behind Enhanced Flax Fibre Mechanical Performance after Cyclic Moisture Conditioningnohttps://cassyni.com/events/AhLjNB21rxLRtm2fMuw3SV?videoPreview=12026-06-17T14:10:00+00:001237.0NoneFlax fibres are a sustainable alternative to synthetic reinforcements in biocomposites, exhibiting beneficial mechanical properties. Unexpectedly, prior research has shown that cyclic high-low humidity conditioning enhances flax fibre mechanical performance, a phenomenon reminiscent of wood hornification. However, the distinct chemical composition and structure of flax, particularly its high cellulose content (65-85%) and pectin-rich middle lamella (unlike wood's lignin-rich middle lamella), suggest a different underlying mechanism. This study investigated the origin of this strengthening and stiffening effect and the role of pectin. Fibre samples underwent cyclic moisture conditioning (85% RH for 2 days, 23% RH for 2 days, at 21 °C), and selected samples were subjected to enzymatic pectin removal using polygalacturonase. Tensile properties of elementary and technical flax fibres were assessed using automated single-fibre testing and impregnated fibre-bundle tests, respectively. X-ray diffraction measured cellulose crystallinity, and micro-computed tomography was used for lumen fraction correction (average 5.47%). Results indicate no significant hornification at the elementary fibre level. In contrast, technical flax fibres showed substantial improvement, with tensile strength and modulus increasing by 23% after 10 moisture cycles. This strengthening effect persisted, with a 20% improvement observed at 50 cycles and 12% after 100 cycles, demonstrating durability. Enzymatic pectin removal abolished the hornification effect on both tensile strength and modulus, confirming pectin's critical role. No statistically significant changes in cellulose crystallinity were detected post-cycling. These findings suggest that the enhanced mechanical performance originates at the technical fibre level and is mediated by the pectin in the middle lamella, possibly through pectin redistribution filling defects, distinct from wood hornification mechanisms.https://cassyni-user-files-prod.s3.amazonaws.com/BtVcTD9dz2iBziC3DbNeVk https://cassyni.com/slides/outline/LaLSQUUQ3ULUtkj6A3drD3 https://cassyni.com/events/LaLSQUUQ3ULUtkj6A3drD3/abstract https://cassyni-user-files-prod.s3.amazonaws.com/En54aqF7Wt4pRWzim4jsCS https://cassyni.com/events/LaLSQUUQ3ULUtkj6A3drD3?videoPreview=1 Developing AI for America’s Cup Sailing – Emirates Team NZnohttps://cassyni.com/events/LaLSQUUQ3ULUtkj6A3drD3?videoPreview=12021-11-19T06:00:00+00:001261.64Business SchoolThis study describes the development and application of an artificial intelligence (AI) system designed to accelerate the iterative design process of hydrofoils for Emirates Team New Zealand in the America's Cup. Faced with the challenge of a new boat class, a vast design parameter space, and limited physical prototypes, the traditional design-simulate-evaluate cycle was constrained by the time-intensive involvement of human sailors in simulators. To overcome this, an AI agent, conceptualized as a 'virtual sailor,' was developed using a reinforcement learning framework. This agent learned optimal sailing strategies by interacting with a high-fidelity simulator, supported by an infrastructure of approximately 1,000 virtualized cloud simulators to expedite training. A critical aspect of the development involved defining a robust reward function, a process informed by the subject-matter expertise of experienced sailors and boat designers. The AI system ultimately achieved sailing performance on par with, and in some cases superior to, human sailors across various wind conditions. This automation transformed the design workflow, allowing designers to evaluate dozens of new foil iterations overnight, a substantial improvement over the previous multi-day process. The enhanced speed and consistency of simulation enabled earlier identification of optimal designs, providing a significant competitive advantage. This successful integration of cutting-edge AI underscored the importance of collaborative development with end-users to build trust and ensure practical adoption within a high-performance environment.https://cassyni-user-files-prod.s3.amazonaws.com/En54aqF7Wt4pRWzim4jsCS https://cassyni.com/events/7Eq8A21EC7P4FLoGqoaEjX/seminar/qa https://cassyni.com/slides/outline/7Eq8A21EC7P4FLoGqoaEjX https://cassyni.com/events/7Eq8A21EC7P4FLoGqoaEjX/abstract https://cassyni-user-files-prod.s3.amazonaws.com/DkrFZRUkg6Ja7JTznPeVAW https://cassyni.com/events/7Eq8A21EC7P4FLoGqoaEjX?videoPreview=1 Indigenous Science and Practice in Ecology and Evolutionnohttps://cassyni.com/events/7Eq8A21EC7P4FLoGqoaEjX?videoPreview=12026-07-28T15:00:00+00:003412.04Ecology and Evolution A fulsome understanding of ecology and evolution is not possible without contributions from Indigenous traditional and local knowledge (TEK/LEK) of ecosystems. These knowledges are inherently tied to land and culture, and their incorporation or implementation requires working with Indigenous Peoples in good ways (Reid et al. 2024). Two-eyed seeing (Etuaptmumk in Mi’kmaw, conceptualized by Elder Albert Marshall), Indigenous science, and community-based approaches to understanding ecology and evolution can provide insight into challenging local- and global-scale problems. Indigenous Peoples globally have been sustainably managing natural resources and safeguarding biodiversity for millennia (Garnett et al. 2018), thus incorporation of Indigenous knowledges and knowledge systems into biodiversity conservation is timely and necessary (Ogar et al. 2020). Combining TEK/LEK with other data sources can identify species range shifts (e.g., Service et al. 2014), climate impacts (Gagnon et al. 2020), and insights into behaviour and habitat use (Dubos et al. 2023). At Ecology and Evolution, we invite Indigenous researchers, scientists using Indigenous practices and approaches, and those working in good ways (Reid et al. 2024) with Indigenous communities, to submit to a new special issue and ongoing special section - Indigenous Science and Practice in Ecology and Evolution. We welcome papers showcasing the use of Indigenous practices and approaches, alone or alongside other approaches to answer ecological and evolutionary questions. Contributions are welcome in all spaces of the journal. Image credit: [Courtney Kenady (Unsplash)](https://unsplash.com/photos/orange-and-blue-flower-field-during-daytime-h5ZPU1hU5CM).https://cassyni-user-files-prod.s3.amazonaws.com/DkrFZRUkg6Ja7JTznPeVAW https://cassyni.com/slides/outline/UyMiC6UKWFkU465ZDtxuRw https://cassyni.com/events/UyMiC6UKWFkU465ZDtxuRw/abstract https://cassyni-user-files-prod.s3.amazonaws.com/3cPCCzurpdZQbQcsjZFxVU https://cassyni.com/events/UyMiC6UKWFkU465ZDtxuRw?videoPreview=1 Defining the limits and trade-offs of plant photosynthetic heat tolerance under extreme heatnohttps://cassyni.com/events/UyMiC6UKWFkU465ZDtxuRw?videoPreview=12026-06-03T07:40:00+00:00740.48Rising atmospheric temperatures are triggering heatwaves at higher frequencies, duration and intensity across the globe, However, our understanding of ‘how hot is too hot?’ for plant function and survival remains limited, largely because of the difficulty of gathering *in situ* empirical data at temperatures that represent the heatwaves of the near future. Located in Phoenix, USA, the Desert Botanical Garden offers a unique opportunity to investigate plant responses to extreme heat by leveraging summer maximum air temperatures that regularly exceed 45 °C. Here, I will present an overview of ongoing research examining plant photosynthetic heat tolerance, highlighting new insights into the physiological dynamics of plant responses under extreme heat. These include the species-specific capacity to employ evaporative cooling to maintain leaf temperatures below the damage thresholds of Photosystem II despite an increased risk of hydraulic failure, as well as evidence of trade-offs between the heat mitigation strategies of transpirational leaf cooling versus Photosystem II heat acclimation that emerge when plants are exposed to air temperatures exceeding 50 °C. These results demonstrate the critical need for continued experimental work conducted at air temperatures that reflect the likely maximum summer temperatures of coming decades.https://cassyni-user-files-prod.s3.amazonaws.com/3cPCCzurpdZQbQcsjZFxVU https://cassyni.com/slides/outline/Tz4W6jBGdLeKPLFZ7vVad3 https://cassyni.com/events/Tz4W6jBGdLeKPLFZ7vVad3/abstract https://cassyni-user-files-prod.s3.amazonaws.com/472oFgZPG67YwcgDACLDKL https://cassyni.com/events/Tz4W6jBGdLeKPLFZ7vVad3?videoPreview=1 Closing Panel discussionnohttps://cassyni.com/events/Tz4W6jBGdLeKPLFZ7vVad3?videoPreview=12026-06-05T09:30:00+00:002323.44This closing panel discussion will integrate insights from across the symposium to reflect on what extreme heat means for the future of plant lifehttps://cassyni-user-files-prod.s3.amazonaws.com/472oFgZPG67YwcgDACLDKL https://cassyni.com/events/7jWMKLAe2vrt4onnduhCuj/abstract https://cassyni-user-files-prod.s3.amazonaws.com/HYGmfr6qyMwdBKprcSQTKU https://cassyni.com/events/3JB7xWcsLJZ5eD6AETM69T/abstract https://cassyni-user-files-prod.s3.amazonaws.com/KG1TH7YUX2M41fGHA2u5yG https://cassyni.com/slides/outline/ohUeVtTN5HyrUZ3EtaSk5 https://cassyni.com/events/ohUeVtTN5HyrUZ3EtaSk5/abstract https://cassyni-user-files-prod.s3.amazonaws.com/PVkzTorbWv6cNhfmViiuHx https://cassyni.com/events/ohUeVtTN5HyrUZ3EtaSk5?videoPreview=1 Quantum Biosensors and Affinity Assaysnohttps://cassyni.com/events/ohUeVtTN5HyrUZ3EtaSk5?videoPreview=12026-07-08T13:00:00+00:004308.28Nanobionics Research GroupThis seminar number five of the Quantum Electrochemistry series translates the foundational physical principles of isoscopy and quantum capacitance into applied methodologies for molecular diagnostics and drug discovery. The core design principle relies on the observation that molecular binding events perturb the thermodynamic quantum capacitance of the interface while leaving the kinetic charge relaxation resistance invariant. By using the reciprocal of the quantum capacitance as the transducer signal, which is proportional to the interfacial quantum energy, the platform provides a direct electrical response to biological recognition without the need for labeled reagents. This response fits the Langmuir isotherm, enabling two distinct analytical pathways from a single measurement. The Hanes-Woolf linearization focuses on spatial occupancy to yield analytical sensitivity metrics suitable for clinical diagnostics, whereas the Nernstian free-energy route extracts certified thermodynamic binding parameters essential for drug discovery. A crucial innovation of this methodology is the internal thermodynamic certification afforded by the invariance of the charge-relaxation resistance, ensuring that the extracted affinity constants are not kinetically biased. The versatility of this framework is demonstrated through multiple applications, including rapid qualitative and quantitative point-of-care assays for Dengue viral proteins, highly sensitive multi-biomarker panels for cancer and neurodegenerative diseases, and attomolar sensitivity achieved using single-layer graphene for cardiovascular markers and respiratory viruses. The presentation concludes by outlining the scalability of these low-dimensional scale structures, highlighting their potential for miniaturization and integration into high-throughput screening arrays. This scalability addresses a major bottleneck in artificial intelligence-driven drug discovery by providing massive, bias-free thermodynamic databases generated entirely in the ideal dilute regime.https://cassyni-user-files-prod.s3.amazonaws.com/PVkzTorbWv6cNhfmViiuHx https://cassyni.com/slides/outline/9DRYLkbKwwbpM45WCmSBA5 https://cassyni.com/events/9DRYLkbKwwbpM45WCmSBA5/abstract https://cassyni-user-files-prod.s3.amazonaws.com/BoCzA8FNg76cifn44R44PY https://cassyni.com/events/9DRYLkbKwwbpM45WCmSBA5?videoPreview=1 HCR • Frontier Advances in Cancer Rehabilitationnohttps://cassyni.com/events/9DRYLkbKwwbpM45WCmSBA5?videoPreview=12026-07-08T08:00:00+00:005777.36NoneTo further advance academic exchanges and cooperation in global healthcare and rehabilitation, the journal [Healthcare and Rehabilitation (HCR)](https://www.keaipublishing.com/en/journals/healthcare-and-rehabilitation/) is pleased to launch the “Qilu International Academic Lecture on Healthcare and Rehabilitation”. This lecture series aims to build an interdisciplinary, high-quality international exchange platform that brings together top experts and young scholars from around the world to explore the latest research trends and cutting-edge topics in the field. On Jul.08, 2026, Ms. Yingchun Zeng, Assistant Professor at National University of Singapore, delivered a report titled Frontier Advances in Cancer Rehabilitation.https://cassyni-user-files-prod.s3.amazonaws.com/BoCzA8FNg76cifn44R44PY https://cassyni.com/events/H7rTJwyVmzKCoaHtFKMKNu/abstract https://cassyni-user-files-prod.s3.amazonaws.com/A4mXvnrrPFfrQ5SsbVyetW https://cassyni.com/slides/outline/5kwZFE6RgTaDXLJjtKuYN1 https://cassyni.com/events/5kwZFE6RgTaDXLJjtKuYN1/abstract https://cassyni-user-files-prod.s3.amazonaws.com/3TG5bJWrbXfP9utYdREBJN https://cassyni.com/events/FdueAu2vTceYNrJmPtfuVw/abstract https://cassyni-user-files-prod.s3.amazonaws.com/CJScfSx5QM8xzZF3jUFyvW https://cassyni.com/events/P47HorVrtchjMF6DFaspRK/abstract https://cassyni-user-files-prod.s3.amazonaws.com/9qTCThMRqJhyHNqXWRn6N2 https://cassyni.com/events/HcyeJLP64acexNqyeft2Rs/abstract https://cassyni-user-files-prod.s3.amazonaws.com/6B5YDLpEsAXHmZrX8ch2p6 https://cassyni.com/events/TX31gZR9YopKZFGFxvjcEZ/seminar/qa https://cassyni.com/slides/outline/TX31gZR9YopKZFGFxvjcEZ https://cassyni.com/events/TX31gZR9YopKZFGFxvjcEZ/abstract https://cassyni-user-files-prod.s3.amazonaws.com/No7KKcvJTU7q7QdoaqB7YJ https://cassyni.com/events/TX31gZR9YopKZFGFxvjcEZ?videoPreview=1 Control over mechanical properties of magneto-mechanical metamaterialsnohttps://cassyni.com/events/TX31gZR9YopKZFGFxvjcEZ?videoPreview=12025-05-27T13:00:00+00:003666.04MetaMATMechanical metamaterials are typically fabricated through the use of a single material and their effective properties depend primarily on the structural design. However, by introducing magnetic inclusions in such structures, it is possible to considerably influence their deformation patterns as a result of magnetic interactions between the magnetic components as well as the response of such elements to the external magnetic field. In this presentation, based on specific examples of magneto-mechanical metamaterials, it will be shown that Poisson's ratio of the system can be controlled via changes in the external magnetic field. It will also be discussed that it is possible to considerably change the wave transmission through the system as a result of the magnetically triggered reconfiguration process. Finally, it will be shown that magnetic interactions between the magnetic components incorporated within the metamaterial can induce the nonreversible deformation process as well as the nonreciprocal behavior.https://cassyni-user-files-prod.s3.amazonaws.com/No7KKcvJTU7q7QdoaqB7YJ https://cassyni.com/events/5m7Hw1Bk6d8aQCV9bjYC9j/seminar/qa https://cassyni.com/slides/outline/5m7Hw1Bk6d8aQCV9bjYC9j https://cassyni.com/events/5m7Hw1Bk6d8aQCV9bjYC9j/abstract https://cassyni-user-files-prod.s3.amazonaws.com/XR8n3Et6fx18vM7fM8E9zW https://cassyni.com/slides/outline/WwvWGCYXrj38bZZbyUkZyf https://cassyni.com/events/WwvWGCYXrj38bZZbyUkZyf/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Q7dDAJqke6ASypMUNtxQ8e https://cassyni.com/events/WwvWGCYXrj38bZZbyUkZyf?videoPreview=1 Stratified Turbulence: Climate’s mysterious mixernohttps://cassyni.com/events/WwvWGCYXrj38bZZbyUkZyf?videoPreview=12026-06-04T18:00:00+00:003934.84AI Institute in Dynamic SystemsStatically stable density stratification is ubiquitous in geophysical flows, with the atmosphere, lakes and oceans all typically having an average density distribution that decreases upwards in a gravitational field. Due to the associated stabilising effect of the buoyancy force, it would seem intuitive that such statically stable density distributions should suppress vertical motions, relative to horizontal motions. Such inevitable anisotropy complicates even further developing an understanding of turbulence in density-stratified fluids. Stratified turbulence is not just an interesting research challenge in classical physics, but also is a key component of the global climate system, as stratified turbulence has a leading order effect on the transport of heat and other scalars such as carbon dioxide, pollutants etc in the world’s oceans and atmosphere. Indeed, how stratified turbulence can actually be born and then survive for a significant period, hence irreversibly mixing significant scalar quantities, are open questions, associated with ongoing controversy in the global research community. In this talk, I will review some recent studies by my collaborators that have advanced our understanding of various key properties of stratified turbulence and mixing, using an appropriate combination of physics-based and data-driven techniques, while also demonstrating that there is still much more to learn about this fascinating and vitally important class of fluid flows https://cassyni-user-files-prod.s3.amazonaws.com/Q7dDAJqke6ASypMUNtxQ8e https://cassyni.com/slides/outline/3na7yXdR9Wme1ChW8igyEd https://cassyni.com/events/3na7yXdR9Wme1ChW8igyEd/abstract https://cassyni-user-files-prod.s3.amazonaws.com/KXWnHwXumsnGYFdX2NgjrN https://cassyni.com/events/3na7yXdR9Wme1ChW8igyEd?videoPreview=1 Confessions at the End of the Day — 'What is Screen Acting' Masterclass & Q&Anohttps://cassyni.com/events/3na7yXdR9Wme1ChW8igyEd?videoPreview=12021-10-21T12:00:00+00:005746.76Hong Kong Baptist UniversityThis live event recording was filmed on 21 October 2021 during the British Council's SPARK Festival of Creativity. The event premiered the short film Confessions at the End of the Day, followed by a live question and answer (Q and A) with some of the students and the programme directors of AGS and CSM performance, as well as a master class led by Professor Michael Bray on the differences of acting for film and acting on stage.https://cassyni-user-files-prod.s3.amazonaws.com/KXWnHwXumsnGYFdX2NgjrN https://cassyni.com/slides/outline/KL6k7PnxE19eGDwb2nLWh https://cassyni.com/events/KL6k7PnxE19eGDwb2nLWh/abstract https://cassyni-user-files-prod.s3.amazonaws.com/75PzNX3BoYhB8fJkPvoGgn https://cassyni.com/events/KL6k7PnxE19eGDwb2nLWh?videoPreview=1 HD212771 — Violin & Dance Improvisationnohttps://cassyni.com/events/KL6k7PnxE19eGDwb2nLWh?videoPreview=12022-04-26T12:00:00+00:00601.36Hong Kong Baptist UniversityNo abstracthttps://cassyni-user-files-prod.s3.amazonaws.com/75PzNX3BoYhB8fJkPvoGgn https://cassyni.com/slides/outline/G8nE8coY7xcVtswK75FhNm https://cassyni.com/events/G8nE8coY7xcVtswK75FhNm/abstract https://cassyni-user-files-prod.s3.amazonaws.com/8WyBosVqYUuq5uEWwPdiFp https://cassyni.com/events/G8nE8coY7xcVtswK75FhNm?videoPreview=1 Getting an academic job in Communicationnohttps://cassyni.com/events/G8nE8coY7xcVtswK75FhNm?videoPreview=12022-08-26T12:00:00+00:008331.24Hong Kong Baptist UniversityThe panel will consist of two phases. The first half will be an overview of what one does to prepare and apply for a job as an academic presented by Michael Kent. The second half will consist of comments from the panel members about how the hiring process works in their own country, and a chance to ask question.https://cassyni-user-files-prod.s3.amazonaws.com/8WyBosVqYUuq5uEWwPdiFp https://cassyni.com/events/LaCKqKty2fhrA4fEmNLJpm/abstract https://cassyni-user-files-prod.s3.amazonaws.com/UKZWX2L2N549GTuy2hYkxe https://cassyni.com/events/LaCKqKty2fhrA4fEmNLJpm?videoPreview=1 The Nature of the Human Personnohttps://cassyni.com/events/LaCKqKty2fhrA4fEmNLJpm?videoPreview=12024-04-16T12:00:00+00:00470.28Hong Kong Baptist UniversityHow do Buddhism, Chinese traditions, and Hinduism address the essence of human sentience? What is consciousness? What is the self? What is qi? Do humans have souls or spirits? Are humans dualistic beings? Or pure souls/spirits?https://cassyni-user-files-prod.s3.amazonaws.com/UKZWX2L2N549GTuy2hYkxe https://cassyni.com/events/UyDbcwttVT7qKQ1hqDfN3f/abstract https://cassyni-user-files-prod.s3.amazonaws.com/577jTXSF8uxrjcH3t3ain2 https://cassyni.com/events/UyDbcwttVT7qKQ1hqDfN3f?videoPreview=1 T03 Decision Trees in Orangenohttps://cassyni.com/events/UyDbcwttVT7qKQ1hqDfN3f?videoPreview=12023-08-07T12:00:00+00:00436.08Hong Kong Baptist UniversityAbstract not yet added.https://cassyni-user-files-prod.s3.amazonaws.com/577jTXSF8uxrjcH3t3ain2 https://cassyni.com/events/TyvPXabqcY1geeBhjFC3Em/abstract https://cassyni-user-files-prod.s3.amazonaws.com/N5pWadkkWwi5x8HAivKEDL https://cassyni.com/events/TyvPXabqcY1geeBhjFC3Em?videoPreview=1 Hell & Universalism Part 2nohttps://cassyni.com/events/TyvPXabqcY1geeBhjFC3Em?videoPreview=12023-04-15T12:00:00+00:006953.04Hong Kong Baptist UniversityAbstract not yet added.https://cassyni-user-files-prod.s3.amazonaws.com/N5pWadkkWwi5x8HAivKEDL https://cassyni.com/slides/outline/oZN5MK2MGfM7nVBrDGuMo https://cassyni.com/events/oZN5MK2MGfM7nVBrDGuMo/abstract https://cassyni-user-files-prod.s3.amazonaws.com/7a3bRCgiF1FGoebruTyoEN https://cassyni.com/events/oZN5MK2MGfM7nVBrDGuMo?videoPreview=1 Páll Ragnar Pálsson: Hermitage for Solo Violinnohttps://cassyni.com/events/oZN5MK2MGfM7nVBrDGuMo?videoPreview=12021-08-15T12:00:00+00:00491.16Hong Kong Baptist UniversityNo abstracthttps://cassyni-user-files-prod.s3.amazonaws.com/7a3bRCgiF1FGoebruTyoEN https://cassyni.com/slides/outline/Ahead6gmHvXRW1h5WAFuPK https://cassyni.com/events/Ahead6gmHvXRW1h5WAFuPK/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Fc4Z1WJfEanudZmNWBG6Gn https://cassyni.com/events/Ahead6gmHvXRW1h5WAFuPK?videoPreview=1 Cultural Governance and Collective Sovereignty: TheCase of Human Rights Museumsnohttps://cassyni.com/events/Ahead6gmHvXRW1h5WAFuPK?videoPreview=12021-06-10T12:00:00+00:001692.24Hong Kong Baptist UniversityThis study examines human rights museums as cultural institutions that perform governance functions to enhance collective sovereignty and legal common sense within communities. It conceptualizes these museums as public spaces that educate on human rights, memorialize historical traumas, and cultivate a shared legal consciousness grounded in human rights norms. The analysis focuses on six national-level museums across the Trans-Pacific region, selected for their historical significance, rich collections, and active public engagement with issues such as immigration, indigenous rights, resistance movements, and the legacies of the Cold War. The project integrates critical legal studies and cultural studies to explore how these museums articulate their missions, respond to socio-political and legal mandates, and employ innovative museological techniques. Emphasis is placed on the museums’ roles in supporting legal processes, such as truth commissions and land restitution claims, and in sustaining transnational networks that promote human rights awareness and cultural justice. The study highlights the dynamic nature of human rights museums as sites where legal meanings are negotiated, contested, and disseminated, contributing to the formation of a trans-Pacific cosmopolitan citizenship. By situating these museums within broader geopolitical and cultural contexts shaped by migration, conflict, and historical exclusion, the research aims to reframe museum studies through a transnational lens that foregrounds the interplay between cultural memory, law, and collective political agency. Fieldwork involving institutional ethnography and artifact analysis is planned to deepen understanding of these processes.https://cassyni-user-files-prod.s3.amazonaws.com/Fc4Z1WJfEanudZmNWBG6Gn https://cassyni.com/slides/outline/BCJBfnLHjP5UVnDy6bYhed https://cassyni.com/events/BCJBfnLHjP5UVnDy6bYhed/abstract https://cassyni-user-files-prod.s3.amazonaws.com/K34YnJwCSthmgWyz8ToU2i https://cassyni.com/events/BCJBfnLHjP5UVnDy6bYhed?videoPreview=1 Race and Religion in Chinanohttps://cassyni.com/events/BCJBfnLHjP5UVnDy6bYhed?videoPreview=12024-03-18T12:00:00+00:004824.28Hong Kong Baptist UniversityWhat are the variety and vitality of lives like in a country where religion is often tightly controlled? How does race or ethnicity inform us of the dynamics of Chinese religions and politics, and of China in general? And most importantly, why should we care? Join award-winning journalist Ian Johnson, Catherine Hardie (Hong Kong Baptist University), and UVA’s Charles Laughlin, who discuss the ways their respective work engages with the entanglement of religion, race, and politics in China.https://cassyni-user-files-prod.s3.amazonaws.com/K34YnJwCSthmgWyz8ToU2i https://cassyni.com/slides/outline/MZVXvhC1uaozppVEsLoddf https://cassyni.com/events/MZVXvhC1uaozppVEsLoddf/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Rptj6B6PyuYqY3Nes197aE https://cassyni.com/events/MZVXvhC1uaozppVEsLoddf?videoPreview=1 Book Talk: Reorienting Chinese Stars in Global Polyphonic Networks: Voicenohttps://cassyni.com/events/MZVXvhC1uaozppVEsLoddf?videoPreview=12021-06-17T12:00:00+00:005349.32Hong Kong Baptist UniversityThis book talk introduces Dorothy Lau's new monograph, Reorienting Chinese Stars in Global Polyphonic Networks: Voice, Ethnicity, Power (2021), and offers a discussion of some of its highlights. It includes an exposition of the methodological shift from the visual-based to aural-based vectors of studying Chinese stars and reimagining Chineseness. The “linguaphonic” model as this book advances moves away from a conceptualization of transnational Chinese stardom reliant on the centrality of either action or body but pivots on specific phonic modalities — spoken forms of tongues, manners of enunciation, styles of vocalization — as means to mine ethnic and ideological underpinnings of Chinese stardom. The talk also features one of the cases covered in the monograph in order to elaborate how the contours of the ethnic fame-making is remapped in the global mediascape.https://cassyni-user-files-prod.s3.amazonaws.com/Rptj6B6PyuYqY3Nes197aE https://cassyni.com/slides/outline/J6xJbufLqNwMo8BgDgRg6q https://cassyni.com/events/J6xJbufLqNwMo8BgDgRg6q/abstract https://cassyni-user-files-prod.s3.amazonaws.com/GJt2WhYKAwHfNKMeh2Cjjk https://cassyni.com/events/J6xJbufLqNwMo8BgDgRg6q?videoPreview=1 Setting up Recording in Paradigm - Ep.29nohttps://cassyni.com/events/J6xJbufLqNwMo8BgDgRg6q?videoPreview=12022-01-04T12:00:00+00:00217.28Hong Kong Baptist UniversityThis abstract details the procedure for integrating a microphone into experiments conducted using the Paradigm software, focusing on its application for precise reaction time measurement. The motivation stems from the need to accurately capture vocal responses in tasks such as the Stroop task, where participants verbally name colors to assess cognitive interference and response delays. The setup involves navigating Paradigm's interface to add and configure a microphone as a response device. Initially, the microphone device must be enabled under the 'Devices' menu, where specific parameters like 'Over Threshold' (recommended 10-20%) and 'Sample Length' (e.g., 1 second) are adjusted to optimize sensitivity. Subsequently, the enabled microphone is assigned to the relevant experimental event, with the 'Voice Key' function activated to detect speech onset. A test run confirmed the successful logging of vocal reaction times for each trial, demonstrating Paradigm's capability to accurately record response latency. This methodology provides a robust approach for researchers to collect quantitative data on vocal reaction times, enhancing the precision of experimental analyses in psycholinguistics and cognitive psychology.https://cassyni-user-files-prod.s3.amazonaws.com/GJt2WhYKAwHfNKMeh2Cjjk https://cassyni.com/slides/outline/XSTcrN8WgjtKgLVGNuZzmb https://cassyni.com/events/XSTcrN8WgjtKgLVGNuZzmb/abstract https://cassyni-user-files-prod.s3.amazonaws.com/UvchNZFhPgEqorFq4Twctv https://cassyni.com/events/XSTcrN8WgjtKgLVGNuZzmb?videoPreview=1 What Defines Hong Kong Artnohttps://cassyni.com/events/XSTcrN8WgjtKgLVGNuZzmb?videoPreview=12020-08-25T12:00:00+00:003680.92Hong Kong Baptist UniversityWe were pleased to have four speakers from different fields in the art industry partaking in this talk: William Lim, renowned Hong Kong architect, art collector, and artist; Elaine Ng, Editor of Art Asia Pacific Magazine; Carmen Shek Cerne, Head of Sale and Senior Specialist on Chinese Paintings from Christie’s; and Alexander Seno, Art Critic and Head of Development at Asia Art Archive, who was the moderator of the discussion. Each speaker shed light on how their experiences with Hong Kong’s art industry have influenced and shaped their understanding of Hong Kong art.https://cassyni-user-files-prod.s3.amazonaws.com/UvchNZFhPgEqorFq4Twctv https://cassyni.com/slides/outline/6k3QYBnGjrCNWtCXrgyu5w https://cassyni.com/events/6k3QYBnGjrCNWtCXrgyu5w/abstract https://cassyni-user-files-prod.s3.amazonaws.com/2rd6N7TnPuTw8oh8Sy7QRc https://cassyni.com/events/6k3QYBnGjrCNWtCXrgyu5w?videoPreview=1 Understanding Wikipedia’s Dark Matter: TRANSLATION AND MULTILINGUAL PRACTICE IN THE WORLD’S LARGEST ONLINE ENCYCLOPAEDIAnohttps://cassyni.com/events/6k3QYBnGjrCNWtCXrgyu5w?videoPreview=12021-12-16T12:00:00+00:005047.32Hong Kong Baptist UniversityThis corpus-based study investigates public narratives surrounding interpreters and interpreting, using Wikipedia as a "looking glass" to examine perceptions of the profession. Drawing on established work on interpreter invisibility and agency, the research addresses how interpretations of interpreting are shaped and circulated. English and Chinese corpora were compiled from Wikipedia articles, talk pages, and WikiNews, utilizing search terms such as "interpret\*," "interpreter(s)," "interpreting," "interpretation," and the Chinese term 口译. Data collection employed WebBootCat and a custom Wiki API, while analysis tools included Sketch Engine, LancsBox for collocation analysis, and IBM Watson Natural Language Understanding for sentiment and entity extraction. Findings from the English corpus indicate that "interpreting" is frequently associated not only with language but also with computer programming (e.g., "program," "compiler," "command") and concepts related to music and literature. In contrast, the Chinese corpus revealed a more focused discourse on interpreting as a professional practice, with fewer computer-related associations and frequent links to terms like "research" and "foreign ministry," including specific professional figures. Sentiment analysis of the English "Language interpretation" article showed a positive overall score (0.368552), with high joy and some negative sentiment linked to the drawbacks of consecutive interpreting. The Chinese counterpart demonstrated an even more positive sentiment (0.507732) and no negative keywords or entities, suggesting a more favourable public perception in Chinese contexts. The study highlights methodological considerations in corpus construction and the combination of quantitative and qualitative analysis, concluding with implications for understanding the status and power dynamics of language professions and advocating for interpreter participation in Wikipedia content creation.https://cassyni-user-files-prod.s3.amazonaws.com/2rd6N7TnPuTw8oh8Sy7QRc https://cassyni.com/slides/outline/7Eh1asRoBJkRWejRT8GhMF https://cassyni.com/events/7Eh1asRoBJkRWejRT8GhMF/abstract https://cassyni-user-files-prod.s3.amazonaws.com/K2yg56fjbLRqMAisbm6xhC https://cassyni.com/events/7Eh1asRoBJkRWejRT8GhMF?videoPreview=1 India in the Global News Spherenohttps://cassyni.com/events/7Eh1asRoBJkRWejRT8GhMF?videoPreview=12021-03-12T12:00:00+00:007598.4Hong Kong Baptist UniversityThis analysis explores India's underrepresentation within the global news sphere, contrasting its sophisticated media system with the persistent dominance of Anglo-American media. The study examines the structural landscape of international news, identifying key players in traditional print, wire, and broadcast media, and assesses the emerging opportunities within the digital domain. It is found that a US-UK news duopoly, comprising agencies like Thomson Reuters and Associated Press and influential outlets such as *The Wall Street Journal*, *Time*, and the BBC, accounts for over 80% of international news flow. This dominance enables the setting of global news agendas, often leading to selective coverage or skewed narratives concerning non-Western perspectives, despite the growth of "contra-flows" from regions like the Arab world and East Asia. Domestically, Indian media exhibits "Bollywoodization" and sensationalism, which further undermine its international credibility and distract from critical national and global issues. While India possesses a demographic advantage in digital adoption and government initiatives like "Digital India" and "Aatmanirbhar Bharat" aim to foster indigenous platforms, its digital presence remains largely reactive and fragmented. The country's significant achievements, such as its large-scale vaccine development, often go unnoticed internationally due to the absence of a coherent external narrative. For India to assert a more effective voice globally, a strategic, professional, and well-resourced media approach, potentially involving public-private partnerships and a clear media policy, is required to project its distinct narrative and counter misleading information.https://cassyni-user-files-prod.s3.amazonaws.com/K2yg56fjbLRqMAisbm6xhC https://cassyni.com/events/Kc5GYQF94uW8KMEQXkNjnm/seminar/qa https://cassyni.com/slides/outline/Kc5GYQF94uW8KMEQXkNjnm https://cassyni.com/events/Kc5GYQF94uW8KMEQXkNjnm/abstract https://cassyni-user-files-prod.s3.amazonaws.com/JmNTtjoxkYtQTnkReYFpht https://cassyni.com/events/Kc5GYQF94uW8KMEQXkNjnm?videoPreview=1 Quantum simulator design and exploration with open source matrix product state codesnohttps://cassyni.com/events/Kc5GYQF94uW8KMEQXkNjnm?videoPreview=12021-06-01T15:00:00+00:004179.6Computer Physics CommunicationsOn the way to universal quantum computing, quantum simulators, specialized quantum computers built on a wide variety of experimental architectures, have already been a huge success and are fulfilling Feynman's original 1982 vision of quantum computing. Each such simulator, of which there are over 300 worldwide presently, requires a dedicated experimental platform and costs on the order of several million dollars to build. Such experiments have many interacting parts often requiring a complex rearrangement and months of work in order to perform a specified quantum computation. A widely accessible and easy to use software tool to shortcut design considerations for quantum simulator experimentalists is much needed. We have created such a tool, OpenMPS, downloaded over 4,500 times to date. Our open source software package, a Python wrapper with a Fortran core, is centered around 1D matrix product state (MPS) and matrix product density operator (MPDO) methods, for both closed and open quantum systems, which any experimentalist can download and easily use locally to design and benchmark their quantum simulator architecture of choice. The software elements include (i) prebuilt generalized Ising, Hubbard, and other quantum many-body models, (ii) different time propagation methods for short and long-range interactions, and (iii) supplemental exact diagonalization and quantum trajectory methods. In this talk, I present the capabilities of this code and a range of applications from my own group including exploring new complexity tools for quantum states taken from neuroscience; finding Kibble-Zurek exponents to predict defect formation in quantum quenches with long-range interactions and complex phase diagrams in more advanced Hamiltonians; discovering new features in entangled non-equilibrium quantum dynamics which establish quantum many-body chaos as a separate and open field from classical and quantum chaos; and discovering new regimes of macroscopic quantum tunneling escape with a half-life based on quantum fluctuations. This survey of research outcomes will demonstrate the wide capabilities and potential of OpenMPS in quantum simulator applications.https://cassyni-user-files-prod.s3.amazonaws.com/JmNTtjoxkYtQTnkReYFpht https://cassyni.com/slides/outline/SX9jByJVDKFupADyuBwfwT https://cassyni.com/events/SX9jByJVDKFupADyuBwfwT/abstract https://cassyni-user-files-prod.s3.amazonaws.com/K4yB6eQeum1EjJsL236ogA https://cassyni.com/events/SX9jByJVDKFupADyuBwfwT?videoPreview=1 Hybrid solid-state electrolytes for lithium metal batteriesnohttps://cassyni.com/events/SX9jByJVDKFupADyuBwfwT?videoPreview=12021-10-13T23:15:00+00:002248.64The MacDiarmid Institute for Advanced Materials and NanotechnologyRechargeable Li metal batteries using Li metal anodes have attracted worldwide interest because of their high theoretical specific capacity (3860 mAh g-1) and lowest electrode potential (-3.040 V vs standard hydrogen electrode). The critical barriers limiting their commercial application include uncontrolled dendritic Li growth and the unstable Li-electrolyte interface resulting in short circuit and possible explosion. Solid-state electrolytes (SSEs) in place of liquid electrolytes are deemed a promising method to solve the safety concerns. Herein, we design and synthesise a series of hybrid solid-state electrolytes (HSSEs) that is Li-ion-conducting and electron insulating for the Li metal anode. The Ta-Nb co-doped ceramic powders with high ionic conductivity (1.04 ×10-3 S cm-1) dispersed in a polymer matrix could significantly enhance HSSEs mechanical properties, and decrease the polymer’s local crystallization, which is favourable for Li-ion transfer. The symmetric cell of PEO-LLZTNO HSSEs showed stable cycling with 56 mV polarization potential under 0.1mA cm2 for ~1040 h at 60 oC, indicating a stable Li | PEO-LLZTNO 10% | Li interface with the ability to suppress lithium dendrite growth. This talk will also present a modified PVDF based HSSE that demonstrates excellent electrochemical performance when it is paired with a high-voltage cathode material NCM811. This cell can survive from the nail test in the air. The PVDF based HSSEs could power a portable game player and wearable ECG kit in the real application. Our research shows that the HSSEs would be promising candidates for the long lifespan safety batteries. https://cassyni-user-files-prod.s3.amazonaws.com/K4yB6eQeum1EjJsL236ogA https://cassyni.com/slides/outline/LbTLyf5r9uPYnHFuHU4BHF https://cassyni.com/events/LbTLyf5r9uPYnHFuHU4BHF/abstract https://cassyni-user-files-prod.s3.amazonaws.com/JcozbKLoxtPcdCYU7YiByp https://cassyni.com/events/LbTLyf5r9uPYnHFuHU4BHF?videoPreview=1 Nanophononic metamaterials: Thermal conductivity reduction by “millions” of local resonancesnohttps://cassyni.com/events/LbTLyf5r9uPYnHFuHU4BHF?videoPreview=12021-04-06T14:00:00+00:004572.4MetaMATThe concept of a metamaterial has been introduced in electromagnetics and acoustics as an artificially structured locally resonant material that exhibits unique, and often extreme, effective properties in the subwavelength regime. Here we introduce the notion of a locally resonant metamaterial to the area of heat transfer at the nanoscale. In contrast to electromagnetic and acoustic metamaterials, the underlying phenomenon is not limited to the subwavelength regime and does not depend on an effective properties characterization. This new type of metamaterial–termed nanophononic metamaterial (NPM) [1-3]–is also fundamentally different from what is known as thermal metamaterials, which are primarily concerned with transformation heat diffusion and not wave-based phenomena. One realization of an NPM is a freestanding silicon membrane (thin film) with a periodic array of nanoscale pillars erected on one or both free surfaces. Heat is transported along the membrane portion of this nanostructured material as a succession of propagating vibrational waves, phonons. The atoms making up the minuscule pillars on their part generate resonant vibrational waves, which we describe as vibrons. These two types of waves linearly interact causing a mode coupling for each pair which appears as an avoided crossing in the pillared membrane’s phonon band structure. This in turn (1) enables the generation of new modes localized in the nanopillar portion(s) and (2) reduces the base membrane phonon group velocities around the coupling regions. In addition, the phonon lifetimes drop due to changes in the scattering environment, including both phonon-phonon scattering and boundary scattering. These three effects inhibit the in-plane thermal transport. Given that the number of vibrons scales with the number of degrees of freedom of a nanopillar, these effects intensify as the size of the nanopillar(s) increases–possibly reaching millions of vibrons–and in principle may be tuned to influence the entire phonon spectrum (which for silicon extends up to over 17 THz). This novel phenomenon thus provides an opportunity for achieving exceptionally strong reductions in the thermal conductivity, with excellent potential for utilization in thermoelectric energy conversion.https://cassyni-user-files-prod.s3.amazonaws.com/JcozbKLoxtPcdCYU7YiByp https://cassyni.com/slides/outline/UzUcmH5mcgoXwccNMKPEW9 https://cassyni.com/events/UzUcmH5mcgoXwccNMKPEW9/abstract https://cassyni-user-files-prod.s3.amazonaws.com/E3jHa74YhKVu8APNeZ9Ksc https://cassyni.com/events/UzUcmH5mcgoXwccNMKPEW9?videoPreview=1 Mechanics and dynamics of two-dimensional quasiperiodic compositesnohttps://cassyni.com/events/UzUcmH5mcgoXwccNMKPEW9?videoPreview=12020-11-03T14:00:00+00:005556.0MetaMATPeriodic configurations have dominated the design of phononic and elastic-acoustic metamaterial structures for the past decades. Unlike periodic crystals, quasicrystals lack translational symmetry but are unrestricted in rotational symmetry. This provides the opportunity to investigate novel classes of quasicrystal inspired elastic composites whose mechanical static and dynamic properties are largely unexplored. This presentation illustrates the performance of continuous elastic quasicrystals composites, here denoted as quasiperiodic (QP) composites, characterized by different rotational symmetry orders which is directly enforced through a design procedure in reciprocal space. Static mechanical properties are investigated as a function of symmetry order and filling fraction. Results indicate that higher order symmetries, such as 8-, 10- and 14-fold, lead to equivalent stiffness characteristics that interpolate those of the constituent materials while maintaining high levels of isotropy for all filling fractions. Thus, QP composites exhibit more uniform strain energy distributions when compared to periodic 4-fold and 6-fold symmetric configurations. Similarly, nearly-isotropic wave propagation is observed over a broader range of frequencies. The spectral dynamic properties are also investigated by enforcing rotational symmetry constraints in a wedge-type unit cell, which allows for the estimation of bandgaps, whose presence is confirmed in frequency response computations. Wave directionality and bandgaps are also estimated through parallel studies conducted on plate structures characterized by QP patterns of surface stubs. These experiments show clear bandgaps, illustrate how wave fronts reflect the rotational symmetry of the domains, and demonstrate that higher order geometries lead to isotropic propagation over a broader range of frequencies. The investigations presented herein open avenues for the general exploration of the properties of quasiperiodic media, with potentials for novel architectured material designs that expand the opportunities provided by periodic media.https://cassyni-user-files-prod.s3.amazonaws.com/E3jHa74YhKVu8APNeZ9Ksc https://cassyni.com/slides/outline/M65KuiDVC11sda6PbLQXuw https://cassyni.com/events/M65KuiDVC11sda6PbLQXuw/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Pxpj2EmRKGSVjopztTjyug https://cassyni.com/events/M65KuiDVC11sda6PbLQXuw?videoPreview=1 Gradient-Free Aerodynamic Shape Optimization using PyFR and MADSnohttps://cassyni.com/events/M65KuiDVC11sda6PbLQXuw?videoPreview=12021-09-30T14:00:00+00:002114.0PyFRThe development of next-generation aircraft will rely on our ability to perform shape optimization using high-fidelity Computational Fluid Dynamics (CFD). Whereas previous low-fidelity solvers, such as the Reynolds Averaged Navier-Stokes (RANS) approach, are amenable to gradient based optimization, high-fidelity fidelity solvers, such as Large Eddy Simulation (LES), are not. LES resolves unsteady turbulent structures, resulting in chaotic divergence of the flow and objective functions when perturbed. As a result, classical sensitivity analysis via the adjoint or tangent methods is unconditionally unstable. In this presentation we demonstrate the utility of a gradient-free Mesh Adaptive Direct Search (MADS) approach for performing shape optimization with LES. We first demonstrate the suitability of MADS for optimizing model problems, specifically the Lorenz system. We then use MADS coupled with PyFR to perform shape optimization of an SD7003 airfoil and two independent optimizations of a T106D turbine cascade. Results demonstrate >20% performance improvement relative to reference designs for both cases. Importantly, these results are obtained within days via two independent levels of parallelism. This demonstrates that aerodynamic shape optimization using LES is now feasible, and that it can be used for practical aerospace geometries.https://cassyni-user-files-prod.s3.amazonaws.com/Pxpj2EmRKGSVjopztTjyug https://cassyni.com/slides/outline/PZKM98T7PHnMzWZx92KAds https://cassyni.com/events/PZKM98T7PHnMzWZx92KAds/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Bpf463j3xdyKdoHMnbZQPg https://cassyni.com/events/PZKM98T7PHnMzWZx92KAds?videoPreview=1 Folk perceptions of language and creativity: figurative language and playnohttps://cassyni.com/events/PZKM98T7PHnMzWZx92KAds?videoPreview=12021-04-30T16:00:00+00:002169.92Linguistics and Applied Language StudiesThe relationship among creativity, humour, and figurative language is often taken for granted, with the assumption that figurative language is naturally also creative and also humorous. This assumption is not necessarily incorrect, as many scholars have drawn theoretical and empirical links among these three phenomena. Regardless of what the researchers say, what do we know about common, folk perceptions of creativity as they relate to figurative language, such as metaphor and sarcasm? In this seminar, Stephen reports on a study designed to measure these perceptions. Participants provided self-ratings of creativity for their own language when compared to preconstructed responses containing different combinations of figurative language. Results from ordinal regression models demonstrate participants were less likely to selfrate their answers as more creative when comparing their answers to preconstructed responses containing figurative language, but only for specific metaphors or instances of sarcasm. Moreover, participants who made explicit attempts to include figurative language or play in their response were significantly more likely to self-rate their answers as more creative. These results suggest layperson perceptions of creativity are influenced by figurative language and language play, aligning well with the current scholarly literature.https://cassyni-user-files-prod.s3.amazonaws.com/Bpf463j3xdyKdoHMnbZQPg https://cassyni.com/slides/outline/6GdCXCok2GQFKdogagaoND https://cassyni.com/events/6GdCXCok2GQFKdogagaoND/abstract https://cassyni-user-files-prod.s3.amazonaws.com/CMceYoaUQNNHzub1GfhiJ2 https://cassyni.com/events/6GdCXCok2GQFKdogagaoND?videoPreview=1 Solving mean-field PDEs with symmetric neural networksnohttps://cassyni.com/events/6GdCXCok2GQFKdogagaoND?videoPreview=12021-02-08T15:00:00+00:003985.76Partial Differential Equations and ApplicationsWe propose numerical methods for solving non-linear partial differential equations (PDEs) in the Wasserstein space of probability measures, which arise notably in the optimal control of mean-field dynamics, and are motivated by models of large population of interacting agents. The method relies first on the approximation of the PDE in infinite dimension by a backward stochastic differential equation (BSDE) with a forward system of $N$ interacting particles. We provide the rate of convergence of this finite-dimensional probabilistic approximation for the solution to the PDE and its $L$-derivative. Next, by exploiting the symmetry of the particles system, we design a machine learning algorithm based on certain types of neural networks, named PointNet and DeepSet, for computing simultaneously the pair solution to the BSDE by backward induction through sequential minimization of loss functions. We illustrate the efficiency of the PointNet/DeepSet networks compared to classical feedforward ones, and provide some numerical results of our algorithm for the examples of a mean-field systemic risk and a mean-variance problem.https://cassyni-user-files-prod.s3.amazonaws.com/CMceYoaUQNNHzub1GfhiJ2 https://cassyni.com/slides/outline/3oPBHna7pydiHUZu7tnSN1 https://cassyni.com/events/3oPBHna7pydiHUZu7tnSN1/abstract https://cassyni-user-files-prod.s3.amazonaws.com/5miQGg3sanBkjwKTDwx7yY https://cassyni.com/events/3oPBHna7pydiHUZu7tnSN1?videoPreview=1 Linguistic discrimination in urban apartment searches: Names and accents across neighborhoodsnohttps://cassyni.com/events/3oPBHna7pydiHUZu7tnSN1?videoPreview=12020-02-14T16:00:00+00:00591.6Linguistics and Applied Language StudiesThis presentation uncovers the role that language plays in the distribution of living spaces in a city. One important factor is the hidden or unhidden stereotypes towards certain ethnicities represented through their speech. These often hidden biases lead to landlords’, landladies’ and real estate agents’ decisions on granting apartment viewings towards speakers of certain ethnic names and accents, but less for others. The language-based discrimination occurs statistically less frequently in the more diverse neighborhoods. A discourse analysis of such conversations shows the subtle moves that potentially disempower minority language speakers and re-establish the unbalanced power relationship of the native speakers and the immigrant applicants.https://cassyni-user-files-prod.s3.amazonaws.com/5miQGg3sanBkjwKTDwx7yY https://cassyni.com/slides/outline/L6n7pLvSK5uixpGPVMwD73 https://cassyni.com/events/L6n7pLvSK5uixpGPVMwD73/abstract https://cassyni-user-files-prod.s3.amazonaws.com/MYVQjiMXqi3UnQLTTTNnrA https://cassyni.com/events/L6n7pLvSK5uixpGPVMwD73?videoPreview=1 12 Labours Seminar Series (Exemplar Project 3): Control of organ function by the autonomic nervous systemnohttps://cassyni.com/events/L6n7pLvSK5uixpGPVMwD73?videoPreview=12022-02-01T23:00:00+00:003417.76Auckland Bioengineering InstituteThis seminar will give an overview of Exemplar Platform 3 (EP3) of the 12 Labours project: Control of organ function by the autonomic nervous system. EP3 seeks to leverage upon preliminary work previously conducted at the Auckland Bioengineering Institute in the Gastrointestinal Motility and Placental Health research groups. In particular, we will present work conducted to date, and planned future work, on mathematical modelling and measurement of intrinsic electrical activity in the stomach and uterus, and its response to external electrical stimulii, homonal changes, and the autonomic nervous system. https://cassyni-user-files-prod.s3.amazonaws.com/MYVQjiMXqi3UnQLTTTNnrA https://cassyni.com/slides/outline/8FkSsuBgRxDSnfDm3d9JYM https://cassyni.com/events/8FkSsuBgRxDSnfDm3d9JYM/abstract https://cassyni-user-files-prod.s3.amazonaws.com/D7jbYHchsJAhcp6Z6txXJe https://cassyni.com/events/8FkSsuBgRxDSnfDm3d9JYM?videoPreview=1 Characterizing the tumor suppressor activity of FLCN in Birt-Hogg-Dubé syndrome cell models through transcriptomic and proteomic analysisnohttps://cassyni.com/events/8FkSsuBgRxDSnfDm3d9JYM?videoPreview=12025-04-08T16:00:00+00:001392.12OncogeneBirt-Hogg-Dubé syndrome (BHD) patients are uniquely susceptible to all renal tumor subtypes. However, the underlying mechanism of carcinogenesis is unclear. To study cancer development in BHD, we used human proximal kidney (HK2) cells and found that long-term folliculin (FLCN) knockdown was required to increase the tumorigenic potential of these cells, as evidenced by the formation of larger spheroids under nonadherent conditions. Transcriptomic and proteomic analyses revealed links between the FLCN, cell cycle control and DNA damage response (DDR) machinery. In addition, HK2 cells lacking FLCN had an altered transcriptome profile and enriched cell cycle control genes. G1/S cell cycle checkpoint signaling was compromised by increased protein levels of cyclin D1 (CCND1) and hyperphosphorylation of retinoblastoma 1 (RB1). A FLCN interactome screen revealed that FLCN binds to DNA-dependent protein kinase (DNA-PK). This novel interaction was reversed in an irradiation-responsive manner. Knockdown of FLCN in HK2 cells caused a marked increase in γH2AX and RB1 phosphorylation. The levels of both CCND1 and phosphorylated RB1 remained high during DNA damage, which was associated with defective cell cycle control caused by FLCN knockdown. Furthermore, Flcn-knockdown C. elegans were defective in cell cycle arrest caused by DNA damage. This work revealed that long-term FLCN loss and associated cell cycle defects in BHD patients could contribute to their increased risk of cancer.https://cassyni-user-files-prod.s3.amazonaws.com/D7jbYHchsJAhcp6Z6txXJe https://cassyni.com/slides/outline/T1oLEex1emoxovksVdEUCm https://cassyni.com/events/T1oLEex1emoxovksVdEUCm/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Cqvk1ziY8eq8Z7qdETvtLW https://cassyni.com/events/T1oLEex1emoxovksVdEUCm?videoPreview=1 Optical Resonances in Metal Nanostructure Lattices, Tuning the Al–M Interactions in Group 1 Aluminylsnohttps://cassyni.com/events/T1oLEex1emoxovksVdEUCm?videoPreview=12021-09-29T23:15:00+00:003486.88The MacDiarmid Institute for Advanced Materials and NanotechnologyNanostructured surfaces exhibiting resonances with long life-times and high quality factors have shown promise in applications including on-chip lasing1 and sensing2. Metal nanostructure with dimensions less than 100 nm can exhibit localised plasmon resonances (LSPR) in the visible spectrum. These structures strongly scatter the incident light resulting in a low quality factor resonance, however, when arranged in a lattice radiation can be supressed resulting in much higher quality factors. These lattices have been used in a range of sensors applications and are also interesting for use as on-chip laser cavities, where polarisation, wavelength and direction of the lasing emission can be controlled by adjusting the lattice parameters. In this presentation I will present the fabrication of lithographically defined metal nanostructure lattices from the single structure to more complex lattices. Angle resolved extinction spectrum measurements will be presented with support from numerical models. Finally, I present modelling of new lattice configuration which converts linear polarisation to elliptical polarisation due to the breaking of geometric symmetry. Aluminium is an earth-abundant material that can be utilised in the +1 oxidation (low-valent) state to affect small molecule activation. For the neutral aluminium(I) systems, the reduction of greenhouse gases (i.e. CO2, N2O) proves to be a more challenging task. However, a relatively new class of anionic aluminium(I) system has been shown to have extreme potency towards activating greenhouse gases, and other small polar (i.e. NH3) and non-polar molecules (i.e. H2). These complexes are termed the aluminyl anions, and they contain a low valent aluminium(I) centre that is supported by a dianionic ligand charge-balanced by a group 1 metal cation. The cation plays a vital role in the reactivity of these complexes, and dictates the structure of the aluminyl in both the solid- and solution-state. Until recently, all of the reported aluminyl systems were exclusive to potassium. This talk details the synthesis of the first sodium and lithium aluminyls, isolated as contacted dimeric pairs (CDPs), and their conversion into the corresponding monomeric ion-pairs (MIPs) and separated ion-pairs (SIPs) using appropriate chelating ligands.https://cassyni-user-files-prod.s3.amazonaws.com/Cqvk1ziY8eq8Z7qdETvtLW https://cassyni.com/slides/outline/AiTdwMdTyPPVnHZUVLMNWh https://cassyni.com/events/AiTdwMdTyPPVnHZUVLMNWh/abstract https://cassyni-user-files-prod.s3.amazonaws.com/8A71ezaWfyf6NkUmcnXQRL https://cassyni.com/events/AiTdwMdTyPPVnHZUVLMNWh?videoPreview=1 The brain's waterscapenohttps://cassyni.com/events/AiTdwMdTyPPVnHZUVLMNWh?videoPreview=12020-12-07T15:00:00+00:003184.68Partial Differential Equations and ApplicationsYour brain has its own waterscape: whether you are reading or sleeping, fluid flows around or through the brain tissue and clears waste in the process. These physiological processes are crucial for the well-being of the brain. In spite of their importance we understand them but little. Mathematics and numerics could play a crucial role in gaining new insight. Indeed, medical doctors express an urgent need for modeling of water transport through the brain, to overcome limitations in traditional techniques. Surprisingly little attention has been paid to the numerics of the brain’s waterscape however, and fundamental knowledge is missing. In this talk, I will discuss mathematical models and numerical methods for the brain's waterscape across scales - from viewing the brain as a poroelastic medium at the macroscale and zooming in to studying electrical, chemical and mechanical interactions between brain cells at the microscale.https://cassyni-user-files-prod.s3.amazonaws.com/8A71ezaWfyf6NkUmcnXQRL https://cassyni.com/slides/outline/RXumKs3D98186DrBVzB74R https://cassyni.com/events/RXumKs3D98186DrBVzB74R/abstract https://cassyni-user-files-prod.s3.amazonaws.com/NHTpJjppVtsfy73M8s3Jwp https://cassyni.com/events/RXumKs3D98186DrBVzB74R?videoPreview=1 12 Labours Seminar Series (Exemplar Project 1): Pulmonary hypertensionnohttps://cassyni.com/events/RXumKs3D98186DrBVzB74R?videoPreview=12022-04-06T00:00:00+00:003598.88Auckland Bioengineering InstitutePulmonary hypertension (PH) is a debilitating and progressive disease that can occur idiopathically or secondary to other chronic disease. PH is classified into five groups based on aetiology and mechanisms. In general, it involves progressive remodelling of the pulmonary circulation and right heart, and abnormally high blood pressures. 12 Labours’ Exemplar Project 1 is developing a cardio-respiratory model linked with a whole body circulation model, to simulate pre- and post-capillary PH. The vision is to provide a patient-specific model that is carefully calibrated to clinical imaging and physiological measurements to test potential diagnostic and treatment strategies, but that also reduces to a pragmatic form for real-time whole-body simulations to monitor patient physiological signals in the home. Our initial studies will establish a clinical modelling workflow to evaluate post-treatment cardio-respiratory function in patients for whom surgical treatment is an option. This will provide a proof-of-concept imaging and data to modelling platform that we will extend to other groups of PH.https://cassyni-user-files-prod.s3.amazonaws.com/NHTpJjppVtsfy73M8s3Jwp https://cassyni.com/slides/outline/EB2VNmg2SxBudgKfLfZVxR https://cassyni.com/events/EB2VNmg2SxBudgKfLfZVxR/abstract https://cassyni-user-files-prod.s3.amazonaws.com/D6JoWF1gT3x6nsuj47yJMt https://cassyni.com/events/EB2VNmg2SxBudgKfLfZVxR?videoPreview=1 Systems Engineering Stories from the New Space Eranohttps://cassyni.com/events/EB2VNmg2SxBudgKfLfZVxR?videoPreview=12021-12-15T18:00:00+00:003646.6Department of AeronauticsThe seminar will focus on the practical considerations involved in developing, building and operating spacecraft and rockets in the 21st century. The discussion will cover typical challenges encountered in the aerospace industry as one takes a project from concept to realized product. We will cover what types of agility, resilience, and skills serve one well when encountered with technical issues. The abundance of information access to a broader group of talented individuals on the Internet, advanced computation, modern communication techniques, advent of rapid prototyping, and reduction of launch costs have all fundamentally changed what is possible in the space industry today. At the same time, good old fashioned experiments and tests are necessary to move projects along.https://cassyni-user-files-prod.s3.amazonaws.com/D6JoWF1gT3x6nsuj47yJMt https://cassyni.com/events/Q42CR58QdUBxdg268oGJiy/abstract https://cassyni-user-files-prod.s3.amazonaws.com/eUKKiSdU2BbDZm5bLtuNe https://cassyni.com/slides/outline/5HPEf6YTx59TbPr3DeCuG1 https://cassyni.com/events/5HPEf6YTx59TbPr3DeCuG1/abstract https://cassyni-user-files-prod.s3.amazonaws.com/QKoi1mnW6vByZD8mNBq6mt https://cassyni.com/events/5HPEf6YTx59TbPr3DeCuG1?videoPreview=1 Non-Hermitian elastodynamics without gain and lossnohttps://cassyni.com/events/5HPEf6YTx59TbPr3DeCuG1?videoPreview=12022-05-17T13:00:00+00:004842.08MetaMATExceptional points are singular states of non-Hermitian systems that generate counterintuitive physics, such as unidirectional transmission and negative refraction. The common approach to access them is by designing parity-time symmetry, which requires a challenging balance between material gain and loss. In this talk, I will show how the unique nature of elastodynamics can be harnessed to mimic gain and loss, generate exceptional points and exotic non-Hermitian wave phenomena, using nothing more than isotropic elastic layers. If time permits, I will briefly show another special feature of elastodynamics, when considering piezoelectric composites. I will show that these composites have effective coupling that does not exist at the microscale, in addition to the Willis coupling. This so-called electromomentum coupling reflects another knob to design the dynamics of the medium, and must be included in order to obtain a physical constitutive description. https://cassyni-user-files-prod.s3.amazonaws.com/QKoi1mnW6vByZD8mNBq6mt https://cassyni.com/slides/outline/MakZ52Nu2pVhT35uPSXW69 https://cassyni.com/events/MakZ52Nu2pVhT35uPSXW69/abstract https://cassyni-user-files-prod.s3.amazonaws.com/GJsNeTJUd7DiaGJjSRnBvE https://cassyni.com/events/MakZ52Nu2pVhT35uPSXW69?videoPreview=1 Verifying global stability of fluid flows despite transient growth of energynohttps://cassyni.com/events/MakZ52Nu2pVhT35uPSXW69?videoPreview=12022-02-09T16:00:00+00:003068.44Department of AeronauticsVerifying nonlinear stability of a laminar fluid flow against all perturbations is a classic challenge in fluid dynamics. All past results rely on monotonic decrease of a perturbation energy or a similar quadratic generalized energy. This "energy method" cannot show global stability of a flow in which perturbation energy may grow transiently. For the many flows that allow transient energy growth but seem to be globally stable (e.g. pipe flow and other parallel shear flows at certain Reynolds numbers) there has been no way to mathematically verify global stability. After explaining why the energy method was the only way to verify global stability of fluid flows for over 100 years, I will describe a different approach that is broadly applicable but more technical. This approach, proposed in 2012 by Goulart and Chernyshenko, uses sum-of-squares polynomials to computationally construct non-quadratic Lyapunov functions that decrease monotonically for all flow perturbations. I will present a computational implementation of this approach for the example of 2D plane Couette flow, where we have verified global stability at Reynolds numbers above the energy stability threshold. This energy stability result for 2D Couette flow had not been improved upon since being found by Orr in 1907. The results I will present are the first verification of global stability – for any fluid flow – that surpasses the energy method. This is joint work with Federico Fuentes (Universidad Católica de Chile) and Sergei Chernyshenko (Imperial College London).https://cassyni-user-files-prod.s3.amazonaws.com/GJsNeTJUd7DiaGJjSRnBvE https://cassyni.com/slides/outline/UVrdqDx8abBD6Kmt3T2ssT https://cassyni.com/events/UVrdqDx8abBD6Kmt3T2ssT/abstract https://cassyni-user-files-prod.s3.amazonaws.com/QM4jA6yPE9sg9gdKrDYpB8 https://cassyni.com/events/UVrdqDx8abBD6Kmt3T2ssT?videoPreview=1 Quantifying relevance in learning and inferencenohttps://cassyni.com/events/UVrdqDx8abBD6Kmt3T2ssT?videoPreview=12022-06-01T12:00:00+00:004327.68Physics ReportsLearning is a distinctive feature of intelligent behaviour. High-throughput experimental data and Big Data promise to open new windows on complex systems such as cells, the brain or our societies. Yet, the puzzling success of Artificial Intelligence and Machine Learning shows that we still have a poor conceptual understanding of learning. These applications push statistical inference into uncharted territories where data is high-dimensional and scarce, and prior information on ``true'' models is scant if not totally absent. Here we review recent progress on understanding learning, based on the notion of "relevance". The relevance, as we define it here, quantifies the amount of information that a dataset or the internal representation of a learning machine contains on the generative model of the data. This allows us to define maximally informative samples, on one hand, and optimal learning machines on the other. These are ideal limits of samples and of machines, that contain the maximal amount of information about the unknown generative process, at a given resolution (or level of compression). Both ideal limits exhibit critical features in the statistical sense: Maximally informative samples are characterised by a power-law frequency distribution (statistical criticality) and optimal learning machines by an anomalously large susceptibility. The trade-off between resolution (i.e. compression) and relevance distinguishes the regime of noisy representations from that of lossy compression. These are separated by a special point characterised by Zipf's law statistics. This identifies samples obeying Zipf's law as the most compressed loss-less representations that are optimal in the sense of maximal relevance. Criticality in optimal learning machines manifests in an exponential degeneracy of energy levels, that leads to unusual thermodynamic properties. This distinctive features is consistent with the invariance of the classification under coarse graining of the output, which is a desirable property of learning machines. This theoretical framework is corroborated by empirical analysis showing i) how the concept of relevance can be useful to identify relevant variables in high-dimensional inference and ii) that widely used machine learning architectures approach reasonably well the ideal limit of optimal learning machines, within the limits of the data with which they are trained.https://cassyni-user-files-prod.s3.amazonaws.com/QM4jA6yPE9sg9gdKrDYpB8 https://cassyni.com/events/9EYSuwCn4NetEacKLBrWEH/seminar/qa https://cassyni.com/slides/outline/9EYSuwCn4NetEacKLBrWEH https://cassyni.com/events/9EYSuwCn4NetEacKLBrWEH/abstract https://cassyni-user-files-prod.s3.amazonaws.com/6WgoqhXAEy1wve2LuMce5C https://cassyni.com/slides/outline/N5TQLy4CGzuJ6CY3PDUeBF https://cassyni.com/events/N5TQLy4CGzuJ6CY3PDUeBF/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Qh9obTfX4gUB1JJ4mXZTLA https://cassyni.com/events/N5TQLy4CGzuJ6CY3PDUeBF?videoPreview=1 A new look at periodic homogenization methods towards generalized continua and applications to architectured materialsnohttps://cassyni.com/events/N5TQLy4CGzuJ6CY3PDUeBF?videoPreview=12022-06-28T13:00:00+00:004087.56MetaMATThe seminar aims to provide a classification of generalized continua constructed by a micromechanical approach, relying on an extension of Hill macrohomogeneity condition for the micromorphic effective medium. Starting from the Cauchy balance equations holding at the microscopic level, equilibrium equations for a micromorphic effective medium are derived. The construction of the static macroscopic variables conjugated to the introduced macroscopic kinematic degrees of freedom relies on the additive decomposition of the microscopic displacement into a homogeneous part and a fluctuation. The homogeneous part represents in an exact manner the effective micromorphic medium, and the fluctuation corrects for its deviation from the initially heterogeneous periodic medium. The homogenized micromorphic constitutive law is derived based on suitable variational principles and the solution of the so-called unit cell BVP’s. Examples of architected media representative of some of the constructed effective generalized media illustrate the proposed homogenization method. An enhanced Timoshenko microstructured beam model is constructed, exhibiting couplings between different deformation modes induced by the response of its underlying tetrachiral microstructure. The ranking of the different effective media with respect to the small-scale parameter (ratio of lattice size to a macroscopic dimension) is established, based on the asymptotic expansion of the homogeneous part of the microscopic displacement. https://cassyni-user-files-prod.s3.amazonaws.com/Qh9obTfX4gUB1JJ4mXZTLA https://cassyni.com/slides/outline/7kdFtWn69MuwxLKbmL7Xyw https://cassyni.com/events/7kdFtWn69MuwxLKbmL7Xyw/abstract https://cassyni-user-files-prod.s3.amazonaws.com/7VYyQo5eMrCCVy3MAFhiK8 https://cassyni.com/events/7kdFtWn69MuwxLKbmL7Xyw?videoPreview=1 Burgers-like wave turbulence in the surf zonenohttps://cassyni.com/events/7kdFtWn69MuwxLKbmL7Xyw?videoPreview=12022-04-12T10:40:00+00:001833.84Water WavesOcean wave fields are made of a large number of waves that are mutually interacting in a random way. It is an important example of wave turbulence (Nazarenko, 2011). Significant achievements for modelling wave turbulence in deep water have been made since the pioneer work of Hasselman (1962). Under the hypotheses of weak nonlinearities and strong dispersion Hasselman derived a kinetic equation for the wave action, which is the basis of current operational wave forecasting models. A remarkable property of Hasselmann kinetic equation is that it possesses a stationary analytical solution that corresponds to a constant flux of energy from high to small wave numbers(Zakharov and Filonenko, 1966). The solution corresponds, in the frequency wave spectrum, to a power law of the form of ω-4 (ω the pulsation), that is in agreement with field observations. In shallow waters, the weak wave turbulence approach is no longer valid because, as the waves propagate shoreward, the nonlinearities increase and the dispersive effects decrease. In the inner surf zone, waves are strongly nonlinear and almost non-dispersive. The interacting random waves become phase-locked and generate sawtooth waves. These coherent structures result from the competition between nonlinear and dissipative processes. During this talk, I will analysed wave dynamics in the inner surf zone. First, I will show that this dynamics has strong similarities with Burgers-like turbulence (Saffman 1968). Then I will present the derivation of a theoretical power spectral density law which describes wave energy from the inertial range to the dissipative range (see figure below). Finally, we will discuss about the implications of this work for predicting energy dissipation and turbulent eddy viscosity in the inner surf zone.https://cassyni-user-files-prod.s3.amazonaws.com/7VYyQo5eMrCCVy3MAFhiK8 https://cassyni.com/slides/outline/4J62ZjFR5A3Jve237fjaT7 https://cassyni.com/events/4J62ZjFR5A3Jve237fjaT7/abstract https://cassyni-user-files-prod.s3.amazonaws.com/AbDmWU9257VY3TVEBFDAK8 https://cassyni.com/events/4J62ZjFR5A3Jve237fjaT7?videoPreview=1 On the Origin of Logical Determinism in Babylonianohttps://cassyni.com/events/4J62ZjFR5A3Jve237fjaT7?videoPreview=12022-04-13T10:40:00+00:005892.32Logica UniversalisIn this paper, I show that the idea of logical determinism can be traced back from the Old Babylonian period at least. According to this idea, there are some signs (omens) which can explain the appearance of all events. These omens demonstrate the will of gods and their power realized through natural forces. As a result, each event either necessarily appears or necessarily disappears. This idea can be examined as the first version of eternalism – the philosophical belief that each temporal event (including past and future events) is actual. In divination lists in Akkadian presented as codes we can reconstruct Boolean matrices showing that the Babylonians used some logical-algebraic structures in their reasoning. The idea of logical contingency was introduced within a new mood of thinking presented by the Greek prose – historical as well as philosophical narrations. In the Jewish genre ’aggādōt, the logical determinism is supposed to be in opposition to the Greek prose.https://cassyni-user-files-prod.s3.amazonaws.com/AbDmWU9257VY3TVEBFDAK8 https://cassyni.com/slides/outline/FAMKamUxjEDnSur4jCyGPw https://cassyni.com/events/FAMKamUxjEDnSur4jCyGPw/abstract https://cassyni-user-files-prod.s3.amazonaws.com/WinFiUL5yKg7FFxe9SRGR4 https://cassyni.com/events/FAMKamUxjEDnSur4jCyGPw?videoPreview=1 Logical constants in abstract frameworks and A Note on Logicality of Generalized Quantifiersnohttps://cassyni.com/events/FAMKamUxjEDnSur4jCyGPw?videoPreview=12021-08-18T10:40:00+00:006074.56Logica UniversalisAbstract Logical Constants A possibility of defining logical constants within abstract logical frameworks is discussed, in relation to abstract definition of logical consequence. We propose using duals as a general method of applying the idea of invariance under replacement as a criterion for logicality. A Note on Logicality of Generalized Quantifiers This note follows up an earlier paper in which a possibility of defining logical constants within abstract logical frameworks was discussed, by using duals as a general method of applying the idea of invariance under replacement as a criterion for logicality. In the present note, this approach is applied to the discussion on logicality of generalized quantifiers. It is demonstrated that generalized quantifiers are logical constants by this criterion.https://cassyni-user-files-prod.s3.amazonaws.com/WinFiUL5yKg7FFxe9SRGR4 https://cassyni.com/slides/outline/H8yMt8awtRNGh6phNjmeT7 https://cassyni.com/events/H8yMt8awtRNGh6phNjmeT7/abstract https://cassyni-user-files-prod.s3.amazonaws.com/8zWD2qHvpghn5sfni5i3ft https://cassyni.com/events/H8yMt8awtRNGh6phNjmeT7?videoPreview=1 As the World Grew Smaller—The Early Vision for The Mathematical Intelligencernohttps://cassyni.com/events/H8yMt8awtRNGh6phNjmeT7?videoPreview=12021-02-27T17:00:00+00:001095.04Mathematical IntelligencerNo abstracthttps://cassyni-user-files-prod.s3.amazonaws.com/8zWD2qHvpghn5sfni5i3ft https://cassyni.com/slides/outline/SXHqm7svE7tYYrHqHsFDKj https://cassyni.com/events/SXHqm7svE7tYYrHqHsFDKj/abstract https://cassyni-user-files-prod.s3.amazonaws.com/JJjnDuMWMhyDm27SwQ8SMC https://cassyni.com/events/SXHqm7svE7tYYrHqHsFDKj?videoPreview=1 The infrastructure of Readingnohttps://cassyni.com/events/SXHqm7svE7tYYrHqHsFDKj?videoPreview=12022-04-27T04:30:00+00:004036.4Stout Research Centre for New Zealand StudiesWhat does the future of reading look like? And is reading in rural areas still a 'thing'? This seminar reflects on Lydia Wevers' beautiful memoir "On Reading". The panel discusses Lydia's commitment to the infrastructure of reading and investigates the current state of reading in Aotearoa New Zealand, the role libraries have to play in our society, and how reading can and should be fostered.https://cassyni-user-files-prod.s3.amazonaws.com/JJjnDuMWMhyDm27SwQ8SMC https://cassyni.com/events/KcDP7Ypa5i8m43JFvRgHB3/seminar/qa https://cassyni.com/slides/outline/KcDP7Ypa5i8m43JFvRgHB3 https://cassyni.com/events/KcDP7Ypa5i8m43JFvRgHB3/abstract https://cassyni-user-files-prod.s3.amazonaws.com/FGv679htEc4XN4FLkFbB2n https://cassyni.com/events/KcDP7Ypa5i8m43JFvRgHB3?videoPreview=1 Recent Progress on Urban Heat Mitigation Technologiesnohttps://cassyni.com/events/KcDP7Ypa5i8m43JFvRgHB3?videoPreview=12022-08-24T09:00:00+00:004217.2ElsevierRegional climate change in cities is the most documented phenomenon of climate change. Higher urban temperatures are documented experimentally for more than 450 major cities in the world. Numerous investigations demonstrate that the mean magnitude of the temperature increase may exceed 4-6 C, while at the peak it may exceed 10 C. The serious increase of the frequency and the strength of heat waves creates strong synergies between the global and regional climate change and intensify the magnitude of the overheating. Urban overheating causes a serious impact both on the energy demand and generation sectors. It increases the cooling energy consumption of buildings, rises the peak electricity demand, and obliges utilities to build additional power plants, it affects seriously health issues and in particular heat related mortality and morbidity, impacts the concentration of pollutants and damages the urban environmental quality, and finally deteriorates the levels of local vulnerability and thermal comfort. To counterbalance the problem of urban overheating, numerous heat mitigation systems and technologies are proposed, and implemented in more than 250 large scale urban projects. Mitigation policies and technologies aim to strengthen the cooling potential of heat sinks and weaken the intensity of the heat sources. Among the developed mitigation technologies, the use of advanced, materials like the recently developed photonic components and the reflective, cool materials, the implementation of additional greenery in buildings and open spaces, the use of passive evaporative systems involving additional irrigation of urban zones and finally the dissipation of the excess heat into the ground seems to provide higher mitigation potential. The present lecture reviews and reports the recent progress and knowledge on the specific impact of current and projected urban overheating in energy, peak electricity demand, air quality, mortality and morbidity and urban vulnerability. In parallel, it discusses new findings related to the characteristics and the magnitude of urban overheating, and reports and analyses recent knowledge on the synergies between urban heat island and heat waves. Finally, it presents recent developments in the field of mitigation and adaptation technologies for buildings and cities and provides inside information on current and future potential.https://cassyni-user-files-prod.s3.amazonaws.com/FGv679htEc4XN4FLkFbB2n https://cassyni.com/slides/outline/T1wSooXSfaSbYcpitJY1b3 https://cassyni.com/events/T1wSooXSfaSbYcpitJY1b3/abstract https://cassyni-user-files-prod.s3.amazonaws.com/DYv2zAQxtLKzNHr98gGfjU https://cassyni.com/events/T1wSooXSfaSbYcpitJY1b3?videoPreview=1 Natural Deduction for Quantum Logicnohttps://cassyni.com/events/T1wSooXSfaSbYcpitJY1b3?videoPreview=12022-08-10T14:00:00+00:004686.0Logica UniversalisThis paper presents a natural deduction system for orthomodular quantum logic. The system is shown to be provably equivalent to Nishimura’s quantum sequent calculus. Through the Curry-Howard isomorphism, quantum $\lambda$-calculus is also introduced for which strong normalization property is established.https://cassyni-user-files-prod.s3.amazonaws.com/DYv2zAQxtLKzNHr98gGfjU https://cassyni.com/slides/outline/5n4TpQhsntdHQrqZ1kKsSD https://cassyni.com/events/5n4TpQhsntdHQrqZ1kKsSD/abstract https://cassyni-user-files-prod.s3.amazonaws.com/7LbgdPsDbYo8P2GiaW6BFL https://cassyni.com/events/5n4TpQhsntdHQrqZ1kKsSD?videoPreview=1 Looking around the corner: non-line-of-sight imaging for reconstructing surfaces of hidden objectsnohttps://cassyni.com/events/5n4TpQhsntdHQrqZ1kKsSD?videoPreview=12022-08-23T04:00:00+00:003500.12The Auckland Bioengineering InstituteNon-line-of-sight (NLOS) imaging refers to computational imaging techniques for reconstructing scenes that are not directly in line of sight from the observer. While current NLOS imaging methods reconstruct either the albedo or surface normals of the hidden scene, the two quantities provide complementary information of the scene, so an efficient method to estimate both simultaneously is desirable. In this talk, I show how the recovery of the two quantities can be formulated as a vector deconvolution problem and solved using the Cholesky–Wiener decomposition. We show that surfaces fitted non-parametrically using our recovered normals are more accurate than those produced with NLOS surface reconstruction methods recently proposed, and are 1,000× faster to compute than using inverse rendering.https://cassyni-user-files-prod.s3.amazonaws.com/7LbgdPsDbYo8P2GiaW6BFL https://cassyni.com/slides/outline/FAmfJDDFme7ge5J61j3tsF https://cassyni.com/events/FAmfJDDFme7ge5J61j3tsF/abstract https://cassyni-user-files-prod.s3.amazonaws.com/4zoSdBze3cL6JQv6Tu5Wxv https://cassyni.com/events/FAmfJDDFme7ge5J61j3tsF?videoPreview=1 Indicators for Open Researchnohttps://cassyni.com/events/FAmfJDDFme7ge5J61j3tsF?videoPreview=12023-03-15T03:00:00+00:007762.88UKRNHow can institutions baseline, plan and assess progress toward open and transparent research, in ways that respect the diversities across the research system, support good practice and efficiency, and do not encourage unhelpful and invalid rankings? In this workshop, you will hear from a range of initiatives working toward this goal, including PLOS, ScholCommLab, the QUEST Center Berlin, the Finnish self-assessment tool and the new EU-funded GraspOS project, as well as a UK funder and university. The workshop will conclude with a UKRN call for the research community to share views on what priorities we should have in monitoring open research; this will inform pilots in a number of UKRN institutions.https://cassyni-user-files-prod.s3.amazonaws.com/4zoSdBze3cL6JQv6Tu5Wxv https://cassyni.com/events/4JWNHAyi7ZwD7oU4QBpCvR/abstract https://cassyni-user-files-prod.s3.amazonaws.com/2HKbTojapjVeLA9tr1ar1t https://cassyni.com/events/T2MnXFFjhzLVjnGkApce4M/abstract https://cassyni-user-files-prod.s3.amazonaws.com/QckKjpbhAzWpTw9WhQbgU6 https://cassyni.com/events/4JCX2FJxgbkDWFDoJ6t1kR/seminar/qa https://cassyni.com/slides/outline/4JCX2FJxgbkDWFDoJ6t1kR https://cassyni.com/events/4JCX2FJxgbkDWFDoJ6t1kR/abstract https://cassyni-user-files-prod.s3.amazonaws.com/DQse7Hxws7RxH9EcAiJDg2 https://cassyni.com/events/4JCX2FJxgbkDWFDoJ6t1kR?videoPreview=1 Peritoneal Dialysis: Problem-based learning 0900-1030nohttps://cassyni.com/events/4JCX2FJxgbkDWFDoJ6t1kR?videoPreview=12025-09-19T08:00:00+00:006983.48Imperial College Renal and Transplant Centrenull Image credit: [Google DeepMind (Unsplash)](https://unsplash.com/photos/a-group-of-different-colored-pills-egDR0kw-Ptw).https://cassyni-user-files-prod.s3.amazonaws.com/DQse7Hxws7RxH9EcAiJDg2 https://cassyni.com/slides/outline/AELs4dmnBnSCtNVzQb1Exu https://cassyni.com/events/AELs4dmnBnSCtNVzQb1Exu/abstract https://cassyni-user-files-prod.s3.amazonaws.com/PWHiPHPmBiGZ2VUHdr3mTk https://cassyni.com/events/AELs4dmnBnSCtNVzQb1Exu?videoPreview=1 Anti-T lymphocyte Globulin plus Posttransplant Cyclophosphamide 25 mg/kg versus Posttransplant Cyclophosphamide 50 mg/kg in Patients with Acute Leukemiasnohttps://cassyni.com/events/AELs4dmnBnSCtNVzQb1Exu?videoPreview=12025-04-18T14:00:00+00:001147.84Bone Marrow TransplantationIn this study, we aimed to compare the engraftment days, graft-versus-host disease (GVHD) development, relapse and overall survival rates in patients using myeloablative/reduced intensity conditioning regimens with posttransplant cyclophosphamide (PTCy) 25 mg/kg x2 with Anti-T lymphocyte Globulin (ATLG) (n = 29) and PTCy 50 mg/kg x2 doses (n = 41) in patients with acute leukemias. Matched related, matched unrelated, 1 mismatched unrelated, and haploidentical donors were selected for the patients. Platelet (median 11 vs 17 days) and neutrophil (median 14 vs 15 days) engraftment times were shorter in ATLG+ PTCy25 treated patients (both p < 0.05); veno-occlusive disease rates, graft failure and poor graft functions were similar between the two approaches (all p > 0.05); cumulative incidences of grade II-IV aGVHD at +100 days, grade III-IV aGVHD at +100 days, and grade II-IV cGVHD at 1-year were comparable between ATLG+PTCy25 and PTCy50 groups (all p > 0.05). Cumulative incidences of relapse and non-relapse mortality at 1-year were similar in two cohorts (both p > 0.05). PTCy50 was associated with a statistically significant benefit in terms of GVHD-free/relapse-free survival (GRFS) at 1-year (p = 0.03). Median GRFS was 115 (95% CI: 42–214) days and 248 (95% CI: 151-not reached) days, respectively [HR was 0.51 (0.28–0.95), p = 0.03; GRFS at 1-year was 20.7% vs 44.3%, respectively]. However, the groups were comparable in terms of PFS and OS. Median PFS was 332 days (95% CI: 182 days-not reached) for ATLG+PTCy25 group. It was not reached (95% CI: 210 days-not reached) for the patients who received PTCy50. Median OS was not reached in either ATLG+PTCy25 (95% CI: 191 days-not reached) or PTCy50 groups (Log rank = 0.42). Our study showed that lowering PTCy dose with ATLG seems to accelerate platelet and neutrophil engraftment rates; confers similar survival and relapse rates, similar acute and chronic GVHD frequency despite increased GRFS at 1-year.https://cassyni-user-files-prod.s3.amazonaws.com/PWHiPHPmBiGZ2VUHdr3mTk https://cassyni.com/events/L6tcGryyvXcdYRU9fo5eQM/abstract https://cassyni-user-files-prod.s3.amazonaws.com/WWsw4immNJwqeg2KGcHESJ https://cassyni.com/events/RY2FnP6kkZi2fq3wgRKYMj/abstract https://cassyni-user-files-prod.s3.amazonaws.com/3kYk9H6sJ5DorBo2FnSCV4 https://cassyni.com/events/3oVfkJdfSRLcs5mfJKvsfK/abstract https://cassyni-user-files-prod.s3.amazonaws.com/SUMrZs29hw8zc87wecWDRg https://cassyni.com/slides/outline/LbZqSB9PmM6TMtTfTuCcaZ https://cassyni.com/events/LbZqSB9PmM6TMtTfTuCcaZ/abstract https://cassyni-user-files-prod.s3.amazonaws.com/TtAu31hkL3qKG2n6ZTUNa https://cassyni.com/events/LbZqSB9PmM6TMtTfTuCcaZ?videoPreview=1 Novel Anticancer Triple Formula Based on Aptamer-Conjugated PEGylated Nanoliposomesnohttps://cassyni.com/events/LbZqSB9PmM6TMtTfTuCcaZ?videoPreview=12025-07-21T10:24:16+00:00548.56Sage Publishing### Background Cancer remains a leading cause of death worldwide, necessitating the development of affordable and innovative therapies to reduce its human and economic burden. ### Objectives In this study, we aimed to develop a synergistic anticancer formula encapsulated in nanoliposomes to enhance efficacy and minimize side effects. Additionally, we explored the effect of aptamer conjugation on the efficacy and stability of the formula. ### Methods The Etoricoxib-β-cyclodextrin complex was prepared using the kneading method, and nanoliposomes were developed via thin film hydration. The AS1411 aptamer was conjugated to the nanoliposomes to target nucleolin, a protein overexpressed in cancer cells. The etoricoxib-β-cyclodextrin complex was characterized using proton nuclear magnetic resonance, and various liposome properties, including size, encapsulation efficiency, and stability, were optimized. The release profiles of the active compounds were evaluated using high-performance liquid chromatography, and their cytotoxicity was assessed in human cancer cell lines. ### Results The nanoliposomes co-loaded with the three agents and their aptamer-conjugated counterpart showed optimal characteristics, with particle sizes of 133.3±1.45 nm and 174.8±4.78 nm, and zeta potentials of -15.26±1.80 mV and -15.66±2.57 mV, respectively. The encapsulation efficiencies were 88.63% (raloxifene), 41.73% (etoricoxib), and 39.26% (naringin) without the aptamer, and 81.99%, 36.66%, and 38.33%, respectively, with the aptamer. The IC50 of the formula for the three co-loaded agents was 167.4 µg/mL for A549 cells and 2.6 µg/mL for MCF-7 cells. Cytotoxicity was further enhanced using their aptamer conjugate, particularly against the MDA-MB-231 cell line. https://cassyni-user-files-prod.s3.amazonaws.com/TtAu31hkL3qKG2n6ZTUNa https://cassyni.com/slides/outline/osDLGymnErLj39bzTbmJd https://cassyni.com/events/osDLGymnErLj39bzTbmJd/abstract https://cassyni-user-files-prod.s3.amazonaws.com/XUJXP55JbdvQnG6cPN73qx https://cassyni.com/events/osDLGymnErLj39bzTbmJd?videoPreview=1 The antibiotic paradox in allogeneic stem cell transplantationnohttps://cassyni.com/events/osDLGymnErLj39bzTbmJd?videoPreview=12025-09-18T10:00:00+00:001360.04Research Seminars by Springer NatureOngoing research addressing the role of microbiota in complications of allogeneic stem cell transplantation has revealed a detrimental role of loss of microbiota diversity on occurrence of GvHD and other complications. This dysbiosis is mainly caused by the use of broad spectrum antibiotics required to treat neutropenic infections in these patients. On the other hand, old data suggested that antibiotic prophylaxis reducing bacterial translocation in the intestinal tract reduces GvHD, associated neutrophil activation and mortality and resulted in recommendation of decontamination. We call this siutation an obvious antibiotic paradox in allogeneic transplantation and try to contribute some explanations by addressing the differential mode of action dependent on the target location: Luminal dysbiosis of stool microbiota may worsen inflammation, while suppression of costimulation by bacterial PAMPs in the GvHD tissues reduces immune activation. https://cassyni-user-files-prod.s3.amazonaws.com/XUJXP55JbdvQnG6cPN73qx https://cassyni.com/slides/outline/EekYegKJbWB2SUxmiktnr9 https://cassyni.com/events/EekYegKJbWB2SUxmiktnr9/abstract https://cassyni-user-files-prod.s3.amazonaws.com/HaWTq5dTvDdNxdvwXPsSvi https://cassyni.com/events/EekYegKJbWB2SUxmiktnr9?videoPreview=1 Clinical Experience of Using Integrated Whole Genome and Transcriptome Sequencing as A Framework for Pediatric and Adolescent Acute Myeloid Leukemia Diagnosis and Risk Assessmentnohttps://cassyni.com/events/EekYegKJbWB2SUxmiktnr9?videoPreview=12025-10-31T17:07:56+00:002020.84LeukemiaPediatric acute myeloid leukemia (AML) exhibits distinct genetic characteristics, including unique driver alterations and mutations with prognostic and therapeutic implications. Cytogenetics study, along with Next Generation Sequencing (NGS) panel testing, have long been the standard for molecular diagnosis of AML. While these approaches enable diagnosis and prognosis determination in most cases, they have limitations—particularly in detecting emerging rare, recurrent genetic abnormalities. In this study, we systematically reviewed our real-time clinical experience with the diagnostic workup of pediatric AML using an integrated whole genome and whole transcriptome sequencing (iWGS-WTS) approach and compared the test results obtained from various methodologies, including whole genome sequencing (WGS), whole exome sequencing (WES), whole transcriptome sequencing (WTS), iWGS-WTS, cytogenetics, and targeted panel NGS. Our findings demonstrate that the iWGS-WTS approach improves the identification of clinically relevant genetic alterations, enhancing precise disease classification and risk assessment. Additionally, the iWGS-WTS approach streamlines sample acquisition and reduces testing redundancy, positioning it as a practical and superior alternative to traditional diagnostic methods in pediatric AML management.https://cassyni-user-files-prod.s3.amazonaws.com/HaWTq5dTvDdNxdvwXPsSvi https://cassyni.com/slides/outline/DBu1yBUHzCe2V3ZnA4L39X https://cassyni.com/events/DBu1yBUHzCe2V3ZnA4L39X/abstract https://cassyni-user-files-prod.s3.amazonaws.com/9SQSf4oNFiD3R19BjjUq2E https://cassyni.com/events/DBu1yBUHzCe2V3ZnA4L39X?videoPreview=1 Reverse Central Dogma: Computational Exploration of Protein-to-Nucleic Acid Information Flownohttps://cassyni.com/events/DBu1yBUHzCe2V3ZnA4L39X?videoPreview=12026-01-20T13:30:00+00:00425.24Microbiome Virtual International ForumThis seminar presentation synthesizes two interconnected research initiatives that together challenge conventional paradigms in molecular biology and drug discovery through advanced computational methodologies. The first project, "Reverse Central Dogma," confronts the foundational principle of molecular biology by demonstrating the theoretical feasibility of reverse information flow from proteins to nucleic acids. Through extensive molecular docking simulations involving 12 distinct peptide motifs and 4 nucleotide types, we identified statistically significant amino acid-nucleotide binding specificities, with arginine-rich peptides exhibiting exceptional preference for guanine nucleotides (ΔG = -9.8 kcal/mol, p < 0.01). We developed and validated a novel reverse translation algorithm that successfully converts protein sequences into probable nucleic acid sequences with confidence levels of 72–83%, employing Boltzmann probability distributions and Monte Carlo sampling. This work establishes a robust theoretical foundation for peptide-guided nucleic acid assembly, with profound implications for origin-of-life scenarios and synthetic biology applications. The second project, "Seed to Lead," translates computational innovation into therapeutic potential by developing a mechanism-driven pipeline to valorize Nepalese hemp seed byproducts for cancer therapy. This research focuses on underutilized lignanamides—bioactive compounds from Cannabis seeds—and employs a three-phase computational-experimental strategy. Through in silico molecular docking, we identified promising lignanamide interactions with Nicotinamide Phosphoribosyltransferase (NAMPT), a critical enzyme in cancer metabolism. Our designed lead compound, CSE-03, demonstrates predicted moderate inhibition with high selectivity (Therapeutic Index: 3.8), addressing the historical failure of potent NAMPT inhibitors due to systemic toxicity. The project integrates phytochemical extraction, ADMET prediction, and in vitro validation to create a cost-effective blueprint for mechanism-guided drug discovery in resource-limited settings. Collectively, this presentation illustrates how computational biology serves as a unifying bridge between theoretical innovation and applied therapeutic development. By employing shared methodologies; molecular docking, statistical modeling, and algorithm development, we simultaneously challenge six decades of biological dogma and propose novel solutions to twenty-year clinical failures. This work not only advances our fundamental understanding of biological information systems but also demonstrates a practical pathway for leveraging local biodiversity to address global health challenges, exemplifying the transformative potential of integrated computational-experimental approaches in modern biotechnology.https://cassyni-user-files-prod.s3.amazonaws.com/9SQSf4oNFiD3R19BjjUq2E https://cassyni.com/slides/outline/9DHRmc1tw8yBcN1ep68dmo https://cassyni.com/events/9DHRmc1tw8yBcN1ep68dmo/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Fz3wkP9qskPqYRFNTGD5tr https://cassyni.com/events/9DHRmc1tw8yBcN1ep68dmo?videoPreview=1 Genomic GC bias correction improves species abundance estimation from metagenomic datanohttps://cassyni.com/events/9DHRmc1tw8yBcN1ep68dmo?videoPreview=12026-01-20T15:00:00+00:00608.0Microbiome Virtual International ForumMetagenomic sequencing measures the species composition of microbial communities, and has revealed the crucial role of microbiomes in the etiology of a range of diseases such as colorectal cancer. Quantitative comparisons of microbial communities are, however, affected by GC-content dependent biases. Here, we present GuaCAMOLE, a computational method to detect and remove GC bias from meta-genomic sequencing data. The algorithm relies on comparisons between individual species in a single sample to estimates the sequencing efficiency at levels of GC content, and outputs unbiased species abundances. GuaCAMOLE thus works regardless of the specific amount or direction of GC-bias present in the data and does not rely on calibration experiments or multiple samples. Applying our algorithm to 3435 gut microbiomes of colorectal cancer patients from 33 individual studies reveals that the type and severity of GC bias varies considerably between studies. In many studies we observe a clear bias against GC-poor species in the abundances reported by existing methods. GuaCAMOLE successfully removes this bias and corrects the abundance of clinically relevant GC-poor species such as F. nucleatum (28% GC) by up to a factor of two. GuaCAMOLE thus contributes to a better quantitative understanding of microbial communities by improving the accuracy and comparability of species abundances across experimental setups.https://cassyni-user-files-prod.s3.amazonaws.com/Fz3wkP9qskPqYRFNTGD5tr https://cassyni.com/slides/outline/E9mUESV9KiWD1TizpZqdVw https://cassyni.com/events/E9mUESV9KiWD1TizpZqdVw/abstract https://cassyni-user-files-prod.s3.amazonaws.com/V4yQLuzB1UX7aQhAieHoVY https://cassyni.com/events/E9mUESV9KiWD1TizpZqdVw?videoPreview=1 Urinary concentrations of a direct ethanol metabolite indicate substantial ingestion of fermenting fruit by chimpanzeesnohttps://cassyni.com/events/E9mUESV9KiWD1TizpZqdVw?videoPreview=12026-02-05T12:00:00+00:001772.8Royal Society PublishingFrugivorous animals routinely ingest fruit sugars and the associated products of microbial fermentation. Yeast-derived ethanol within fruit is a recently described chronic feature (~14 g/day) of the chimpanzee diet, but physiological evidence of exposure has not yet been demonstrated. We assayed urine collected from 19 wild chimpanzees for the presence of ethyl glucuronide (EtG), a direct metabolite of ethanol. Urine samples were obtained from study individuals feeding almost exclusively in the canopy of mast-fruiting *Gambeya albida* (=*Chrysophyllum albidum*), freshly fallen fruits of which averaged a pulp-ethanol content of 0.09% (±0.01 SE; range 0.01–0.40%) across multiple ripe crops. Of twenty individual urine samples (nine from females and eleven from males, aged 10–46 years), seventeen tested positive for EtG at an analytical threshold of 300 ng/mL; out of a subset of eleven of these positive samples, ten samples further tested positive at a threshold of 500 ng/mL. These values are high relative to calibrations of the test method for modern humans, and are consistent with substantial rates of ethanol consumption via frugivory in the wild.https://cassyni-user-files-prod.s3.amazonaws.com/V4yQLuzB1UX7aQhAieHoVY https://cassyni.com/events/7jNEkBbD28EFL7iwFEPfXT/abstract https://cassyni-user-files-prod.s3.amazonaws.com/D1eaXqTBigkZKMzS5NYMZg https://cassyni.com/events/4Gq1RQ4XwvMcJRRNba1hzd/seminar/qa https://cassyni.com/slides/outline/4Gq1RQ4XwvMcJRRNba1hzd https://cassyni.com/events/4Gq1RQ4XwvMcJRRNba1hzd/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Epm9CmJoCGnuETtGVziDYr https://cassyni.com/events/4Gq1RQ4XwvMcJRRNba1hzd?videoPreview=1 COIK Derived Forms and the Learnernohttps://cassyni.com/events/4Gq1RQ4XwvMcJRRNba1hzd?videoPreview=12026-05-22T01:10:00+00:003036.16Linguistics and Applied Language StudiesIf a learner knows the word 'happy' and the suffix '‑ness', it is sometimes assumed that 'happiness' will present little difficulty in receptive contexts. However, many derived forms are far less transparent. The word 'suggestion' (suggest + -ion) is clear but 'suggestive' requires pragmatic knowledge not inherent in the word. In some cases, the root may be polysemous ('match'), while derived forms may select only one of the root's senses ('matchless'). In other cases, the derived form may be polysemous even when the root isn't because the process of derivation introduces a metaphor ('salty', 'juicy'). Other derived forms require a small leap: argue --> arguably; create --> creative; remark --> remarkable. This seminar presents a list of COIK ('Clear Only If Known') derived forms.. The goal of this research is twofold: first, to present a list of derived words that learners may find problematic (and which instructors and materials developers might overlook); and second, to inform work on learners' ability to make sense of unfamiliar words with whose parts are already known by distinguishing derived forms that may be guessable from those that probably aren't. https://cassyni-user-files-prod.s3.amazonaws.com/Epm9CmJoCGnuETtGVziDYr https://cassyni.com/slides/outline/CfuXSH6EDRd6Rvvs9f7Nm3 https://cassyni.com/events/CfuXSH6EDRd6Rvvs9f7Nm3/abstract https://cassyni-user-files-prod.s3.amazonaws.com/L8ZWs9KcS3f8LWgRjiAzi https://cassyni.com/events/CfuXSH6EDRd6Rvvs9f7Nm3?videoPreview=1 Strain-level genetic heterogeneity and colonization dynamics drive microbiome therapeutic efficacynohttps://cassyni.com/events/CfuXSH6EDRd6Rvvs9f7Nm3?videoPreview=12026-04-21T02:00:00+00:00754.24Microbiome Virtual International ForumFecal microbiota transplantation (FMT) has shown immunotherapeutic promise, yet its efficacy in non-small-cell lung cancer (NSCLC) remains unclear. We demonstrate that FMT improves anti-PD-1 efficacy and progression-free survival in a single-arm trial of advanced PD-L1-negative NSCLC. Analyzing over 2,000 metagenomes from diverse disease cohorts and healthy controls via a high-resolution strain-tracking framework, we reveal that phylogenetically distinct strains within identical species exert opposing therapeutic effects, resolving prior inconsistencies. We identify conserved ecological principles where engraftment relies on species-intrinsic metabolic and immune evasion traits. Crucially, successful colonization by specific beneficial strain variants correlates with positive clinical outcomes. Finally, we identify 38 priority species with robust engraftment potential and significant heterogeneity as candidates for precision therapeutics. These findings establish a strain-function-efficacy paradigm, elucidating the mechanistic basis of variable outcomes and guiding next-generation microbiome drug development.https://cassyni-user-files-prod.s3.amazonaws.com/L8ZWs9KcS3f8LWgRjiAzi https://cassyni.com/slides/outline/P3XDQdgFS3FUHDTnFfAYAH https://cassyni.com/events/P3XDQdgFS3FUHDTnFfAYAH/abstract https://cassyni-user-files-prod.s3.amazonaws.com/UfwrPcNvBxDy33y4rRMxNa https://cassyni.com/events/P3XDQdgFS3FUHDTnFfAYAH?videoPreview=1 Quantum Phase Diagrams and Transitions for Chern Topological Insulatorsnohttps://cassyni.com/events/P3XDQdgFS3FUHDTnFfAYAH?videoPreview=12026-05-22T10:00:00+00:001848.4Annals of PhysicsTopological invariants such as Chern classes are central to the classification of topological phases. When system parameters vary, phase diagrams emerge in which these invariants can jump across critical loci, signaling a breakdown of topology. Our results place the behavior of Chern classes in phase diagrams on a robust theoretical foundation, unifying mathematical theory with concrete physical realizations. We give a fundamental mathematical analysis of this phenomenon and prove that any given abstract phase diagram of Chern phases can be realized through covering (winding) maps. The data of such a diagram can be given by specifying concrete physical systems with the given Chern classes. We provide examples of such systems, and construct explicit families exhibiting arbitrary Chern jumps, with critical loci governed by classical rose curves. These curves achieve the minimal number of Dirac points required, reflecting their role as local topological charges. Our analysis establishes this behavior as generic and unavoidable. To provide concrete condensed matter examples, we examine various lattices and tight-binding models, showing that effective winding maps—and hence higher Chern numbers—can be realized via th nearest-neighbor couplings. We give explicit formulas for a family of 2D lattices using imaginary quadratic field extensions and their norms. Our study includes the square, triangular, honeycomb and Kagome lattices. https://cassyni-user-files-prod.s3.amazonaws.com/UfwrPcNvBxDy33y4rRMxNa https://cassyni.com/slides/outline/3nGGibxfiYaePx35zUN7Ho https://cassyni.com/events/3nGGibxfiYaePx35zUN7Ho/abstract https://cassyni-user-files-prod.s3.amazonaws.com/AUq7Nk6HpBFNa6zaMzMcyL https://cassyni.com/events/3nGGibxfiYaePx35zUN7Ho?videoPreview=1 Bloch Motions and Spinning Topsnohttps://cassyni.com/events/3nGGibxfiYaePx35zUN7Ho?videoPreview=12026-06-25T10:16:36+00:001785.84Annals of PhysicsThis work investigates the dynamics of closed quantum systems in the Bloch vector representation using methods from rigid body dynamics and the theory of integrable systems. To this end, equations of motion for Bloch components are derived from the von Neumann equation that are mathematically equivalent to equations of motion for a distribution of point masses from classical mechanics. Furthermore, using the Heisenberg equation, another system of Bloch vector equations is derived, which constitutes an Euler–Poinsot system of the type commonly encountered in the theory of torque-free spinning tops. This insight is used to prove the Liouville integrability of the corresponding Hamilton equations of motion and to construct an explicit closed-form solution using the Arnold–Liouville theorem. Within the same framework, stability criteria for quantum dynamics are then derived which correspond to the Energy-Casimir method of classical Newtonian mechanics. Following that, specific solutions to the equations of motion are constructed that encode the complex dynamics of composite quantum systems. Eventually, to show that this formalism provides concrete physical predictions, an analogue of the intermediate axis theorem is derived and the effect of oscillating entanglement is discussed. As a basis for this, special types of solutions to the equations of motion are derived that constitute oscillating entangled states, i.e., dynamical quantum states that change their entanglement structure from maximally entangled to separable and vice versa.https://cassyni-user-files-prod.s3.amazonaws.com/AUq7Nk6HpBFNa6zaMzMcyL https://cassyni.com/events/G8UNsh8ngzRWHdGtxpvqRw/abstract https://cassyni-user-files-prod.s3.amazonaws.com/KePJutmtxH5qd2hWr74qrE https://cassyni.com/events/L6FHeP8bfEJv91nAQ2cq4h/abstract https://cassyni-user-files-prod.s3.amazonaws.com/YVe1A35j99Gkdyfgr7jRTC https://cassyni.com/events/2JQKvSZkcFhaVe1BEfXaqB/abstract https://cassyni-user-files-prod.s3.amazonaws.com/46arXaUckjnCJFrEKWqUoQ https://cassyni.com/events/F9ER1asWcoAiZPKFbnYwKj/abstract https://cassyni-user-files-prod.s3.amazonaws.com/QVavUegp4dNo3gpja2JYqC https://cassyni.com/slides/outline/4meM9roNoYU4raUjnMSDZ7 https://cassyni.com/events/4meM9roNoYU4raUjnMSDZ7/abstract https://cassyni-user-files-prod.s3.amazonaws.com/MMWebPF4pYsf7ozAjTpomx https://cassyni.com/events/4meM9roNoYU4raUjnMSDZ7?videoPreview=1 Extinction Debt and Colonisation Credit in Conservation Sciencenohttps://cassyni.com/events/4meM9roNoYU4raUjnMSDZ7?videoPreview=12026-09-17T11:00:00+00:00714.84Royal Society PublishingExtinction debt and colonisation credit describe the delayed impacts of environmental change on biodiversity, yet their significance largely remains unrecognised by those shaping conservation efforts. To address this gap, we conducted a systematic review of 127 empirical studies quantifying these biological lags across taxa, habitats, and anthropogenic drivers. Our synthesis revealed geographic biases, with research concentrated in Northern Hemisphere terrestrial ecosystems, alongside taxonomic and habitat biases that continue to limit our understanding of these dynamics. Evaluation of anthropogenic drivers revealed a similarly skewed research effort, with habitat fragmentation dominating extinction debt studies and land-use change leading colonisation credit research. By synthesising proposed conservation strategies, we identified pathways for integrating time-lagged ecological responses into conservation frameworks. Despite the conceptual importance of these lags, most empirical efforts remain focused on isolated taxonomic groups, with limited consideration of how debts and credits propagate through communities or influence ecosystem services. This narrow focus restricts the utility of current findings for broad-scale conservation. We recommend that future research prioritises the mechanisms driving lags across understudied ecosystems and environmental contexts. Crucially, conservation interventions must move beyond static biodiversity snapshots and explicitly account for extinction debt and colonisation credit to ensure long-term ecosystem resilience.https://cassyni-user-files-prod.s3.amazonaws.com/MMWebPF4pYsf7ozAjTpomx https://cassyni.com/events/CBNQr7WFPQmuMA1CkEHwy7/abstract https://cassyni-user-files-prod.s3.amazonaws.com/3Fz9XarhH8MYE2eVSKZG2A https://cassyni.com/events/8F2FuXndxa8YzF7Kcrjp8D/seminar/qa https://cassyni.com/slides/outline/8F2FuXndxa8YzF7Kcrjp8D https://cassyni.com/events/8F2FuXndxa8YzF7Kcrjp8D/abstract https://cassyni-user-files-prod.s3.amazonaws.com/31Uusxf9a5ytUMQTP2aBYz https://cassyni.com/events/8F2FuXndxa8YzF7Kcrjp8D?videoPreview=1 Federated learning in digital healthcarenohttps://cassyni.com/events/8F2FuXndxa8YzF7Kcrjp8D?videoPreview=12024-11-06T15:30:00+00:004725.04Cell Press, PatternsIn an era where data privacy and accessibility are paramount, federated learning emerges as a transformative paradigm, enabling collaborative AI model training across distributed healthcare datasets. This special collection brings together pioneering research and insights from academia and industry, exploring the intersection of federated with the future of data-driven healthcare. Join us in unravelling the potential of federated learning to revolutionize healthcare delivery while safeguarding patient privacy.https://cassyni-user-files-prod.s3.amazonaws.com/31Uusxf9a5ytUMQTP2aBYz https://cassyni.com/slides/outline/Ff93CbhvBVQWqz3LhkEfsT https://cassyni.com/events/Ff93CbhvBVQWqz3LhkEfsT/abstract https://cassyni-user-files-prod.s3.amazonaws.com/7PuwLPKibS5xESc3cPgkvz https://cassyni.com/events/Ff93CbhvBVQWqz3LhkEfsT?videoPreview=1 μGrowthDB: querying, visualizing, and sharing microbial growth curve datanohttps://cassyni.com/events/Ff93CbhvBVQWqz3LhkEfsT?videoPreview=12026-03-24T12:30:00+00:00490.8Microbiome Virtual International ForumMicrobial growth curve data contain valuable information about microorganisms' physiology and metabolism. However, they are currently reported in various formats scattered across publications. A generic resource that allows querying and comparing microbial growth curve data is currently missing. For this reason, we developed μGrowthDB, an open repository designed to store, visualize, analyze, and share quantitative measurements of species abundances and metabolite profiles from monocultures and communities of known composition. μGrowthDB is designed to accommodate a range of experimental designs and measurement techniques. In addition to querying microbial growth curves by organism or metabolite, μGrowthDB supports comparative visualisation of growth curves and offers a guided data submission process intended to make data upload as easy as possible. μGrowthDB is available at: https://mgrowthdb.gbiomed.kuleuven.be/.https://cassyni-user-files-prod.s3.amazonaws.com/7PuwLPKibS5xESc3cPgkvz