https://cassyni.com/slides/outline/XLMsw7oJt5wuCACHYNTD6m https://cassyni.com/events/XLMsw7oJt5wuCACHYNTD6m/abstract https://cassyni-user-files-prod.s3.amazonaws.com/HwBesbU36AeirP96SkU7TU https://cassyni.com/events/XLMsw7oJt5wuCACHYNTD6m?videoPreview=1 Epigenetics behind tumor immunology: a mini reviewnohttps://cassyni.com/events/XLMsw7oJt5wuCACHYNTD6m?videoPreview=12024-03-22T15:00:00+00:002289.0OncogeneImmunogenic- and immune-therapies have become hot spots in the treatment of cancer. Although promising, these strategies are frequently associated with innate or acquired resistance, calling for combined targeting of immune inhibitory signals. Epigenetic therapy is attracting considerable attention as a combination partner for immune-based therapies due to its role in molding the state and fate of cancer and immune cells in the tumor microenvironment. Here, we describe epigenetic dysregulations in cancer, with a particular focus on those related to innate immune signaling and Type I interferons, and emphasize opportunities and current efforts to translate this knowledge into treatment regimens with improved clinical benefit.https://cassyni-user-files-prod.s3.amazonaws.com/HwBesbU36AeirP96SkU7TU https://cassyni.com/events/F2rSx3PSnXy2bptZytq4tM/seminar/qa https://cassyni.com/slides/outline/F2rSx3PSnXy2bptZytq4tM https://cassyni.com/events/F2rSx3PSnXy2bptZytq4tM/abstract https://cassyni-user-files-prod.s3.amazonaws.com/PzZFL5LutURiDJQejWHtYW https://cassyni.com/events/F2rSx3PSnXy2bptZytq4tM?videoPreview=1 Studies of (unsteady) vehicle areodynamics: test rigs at DLR Göttingennohttps://cassyni.com/events/F2rSx3PSnXy2bptZytq4tM?videoPreview=12023-05-30T14:00:00+00:003077.48Experiments in FluidsAerodynamics of ground vehicles are crucial for safe transportation. Studies of the aerodynamic behaviour of a vehicle are often performed with steady inflow conditions. However, real life conditions are rarely steady. In this talk I will present two test facilities at DLR Göttingen, which are capable of providing unsteady test conditions for various aerodynamic tests. The Crosswind Test Facility Göttingen is a Göttingen-type wind tunnel, which is equipped with a flap system to generate disturbances of the flow. The loads and moments on vehicles under unsteady inflow conditions can be tested depending on the frequency and amplitude of the disturbed flow. The Tunnel Simulation Facility Göttingen is a moving model rig. Unsteady and instantanious aerodynamic effects can be studied using various ground vehicles like cars or trains.https://cassyni-user-files-prod.s3.amazonaws.com/PzZFL5LutURiDJQejWHtYW https://cassyni.com/events/QRCYwfCJXbR2c447BbF5Pb/seminar/qa https://cassyni.com/slides/outline/QRCYwfCJXbR2c447BbF5Pb https://cassyni.com/events/QRCYwfCJXbR2c447BbF5Pb/abstract https://cassyni-user-files-prod.s3.amazonaws.com/EufpkQvmgyvXpTKLWNvqnv https://cassyni.com/events/QRCYwfCJXbR2c447BbF5Pb?videoPreview=1 An Intensional Formalization of Generic Statementsnohttps://cassyni.com/events/QRCYwfCJXbR2c447BbF5Pb?videoPreview=12023-04-19T14:00:00+00:003723.48Logica UniversalisA statement is generic if it expresses a generalization about the members of a kind, as in, ’Pear trees blossom in May,’ or, ’Birds lay egg’. In classical logic, generic statements are formalized as universally quantified conditionals: ’For all x, if ..., then ....’ We want to argue that such a logical interpretation fails to capture the intensional character of generic statements because it cannot express the generic statement as a simple proposition in Aristotle’s sense, i.e., a proposition containing only one single predicate. On the contrary, we’ll show that lambda abstraction and combinatory logic can help us transform the classical, non-simple and extensional expression of generic statements into a new, simple and intensional formalization, through the introduction of an operator that we will call ALL*. We will show that this new operator allows for the possibility of a single predication, e.g. fly(), because it builds, out of a concept like ’bird’, a concrete universal, e.g. ’birds’, upon which the single predicate can be applied to authentically formalize a generic statement, e.g. ’birds fly’.https://cassyni-user-files-prod.s3.amazonaws.com/EufpkQvmgyvXpTKLWNvqnv https://cassyni.com/events/H1UVFQVRwj7Wr1sCdRdSwX/seminar/qa https://cassyni.com/slides/outline/H1UVFQVRwj7Wr1sCdRdSwX https://cassyni.com/events/H1UVFQVRwj7Wr1sCdRdSwX/abstract https://cassyni-user-files-prod.s3.amazonaws.com/7ZZ97HBTsvaFCm8ntfJrce https://cassyni.com/events/H1UVFQVRwj7Wr1sCdRdSwX?videoPreview=1 How Your Journal Can Support and Amplify the Sustainable Development Goalsnohttps://cassyni.com/events/H1UVFQVRwj7Wr1sCdRdSwX?videoPreview=12023-06-29T08:00:00+00:002841.64Topics at the heart of our communityBuilding on the success of [last year's event](https://www.springernature.com/gp/advancing-discovery/spotlight-on), join us this June to learn more about Springer Nature’s Sustainable Development Goal (SDG) Programme and how journals are supporting and amplifying the SDGs. https://cassyni-user-files-prod.s3.amazonaws.com/7ZZ97HBTsvaFCm8ntfJrce https://cassyni.com/events/KUiWUpj491t1CxLmB7Y5fT/seminar/qa https://cassyni.com/slides/outline/KUiWUpj491t1CxLmB7Y5fT https://cassyni.com/events/KUiWUpj491t1CxLmB7Y5fT/abstract https://cassyni-user-files-prod.s3.amazonaws.com/GKEoz4vRkQ32aGnqdQK6HC https://cassyni.com/events/KUiWUpj491t1CxLmB7Y5fT?videoPreview=1 Ptolemy’s Almagest and the translation of diagrams in the twelfth-century Mediterraneannohttps://cassyni.com/events/KUiWUpj491t1CxLmB7Y5fT?videoPreview=12023-05-17T14:00:00+00:003059.64Royal Society PublishingIn this seminar *Notes and Records* editor, Professor Anna Marie Roos will interview Dr Robin S. Reich about her *Notes and Records* prize winning essay 'Ptolemy's Almagest and the translation of diagrams'. Mathaematikae Syntaxis of Claudius Ptolemy, written in the second century, was one of the most influential texts for medieval astronomy. Originally written in Greek and subsequently available in Arabic, this text, known as the Almagest throughout the Middle Ages, was translated into Latin for the fist time in the twelfth century in Sicily, and then again 75 years later in Toledo. Both the translators of these two versions and modern scholars have claimed that the text was translated into Latin twice because meaningful differences existed between the Greek version that was the source of the Sicilian translation and the Arabic that was the source of the Toledan. The implication is that these two different lineages yielded two different traditions of the Almagest in Latin. Alongside the text, many versions of this work include extensive diagrams. This essay considers how the transmission of the Almagest across languages is reflected in these diagrams. It argues that the consistency of the diagrams across different versions of the text reveals a more interconnected transmission with greater communication across languages than is otherwise indicated by the translation of the text. This discussion relies on a deep consideration of the role of diagrams in scientific texts, and has implications for how we understand the impact of translation on the preservation of complex scientific concepts. https://cassyni-user-files-prod.s3.amazonaws.com/GKEoz4vRkQ32aGnqdQK6HC https://cassyni.com/events/YKbqoE4axHCgvQ9vuQq7Cy/seminar/qa https://cassyni.com/slides/outline/YKbqoE4axHCgvQ9vuQq7Cy https://cassyni.com/events/YKbqoE4axHCgvQ9vuQq7Cy/abstract https://cassyni-user-files-prod.s3.amazonaws.com/J1N4JMbi4rkutQCC21DNuc https://cassyni.com/events/YKbqoE4axHCgvQ9vuQq7Cy?videoPreview=1 From Top-down Microarchitecture Analysis to Structured Performance Optimizationsnohttps://cassyni.com/events/YKbqoE4axHCgvQ9vuQq7Cy?videoPreview=12023-09-11T10:00:00+00:002039.12HiPEDS CentreThis session re-caps on the Top-down µarch Analysis (TMA) method - that is widely adopted in performance profiling tools, Microarchitecture challenges faced in out-of-order cores, and the abstraction that helped the method to be universally supported across CPU vendors (Intel as well as AMD & ARM). Then, we show how the primary TMA metrics of Frontend Bound, Bad Speculation, Core Bound, Memory Bound and Retiring can be used to classify and direct exploitation of popular software optimizations. The session closes with a use-case that got deployed in code generation of modern compilers. The use-case demonstrates how to mitigate Instruction Fetch Bandwidth issue through tuning of loop unrolling to speedup tight loops in recent wide-issue out-of-order cores.https://cassyni-user-files-prod.s3.amazonaws.com/J1N4JMbi4rkutQCC21DNuc https://cassyni.com/slides/outline/Qusn6yMiNQuBAMy2MFDUku https://cassyni.com/events/Qusn6yMiNQuBAMy2MFDUku/abstract https://cassyni-user-files-prod.s3.amazonaws.com/BpN4q25gQ9DFFw7wYn7Mvn https://cassyni.com/events/TP7oLPbLZhffXJSatw87Uq/seminar/qa https://cassyni.com/slides/outline/TP7oLPbLZhffXJSatw87Uq https://cassyni.com/events/TP7oLPbLZhffXJSatw87Uq/abstract https://cassyni-user-files-prod.s3.amazonaws.com/WcVHuWHW4o3ifGfepqQSi https://cassyni.com/events/TP7oLPbLZhffXJSatw87Uq?videoPreview=1 High Impact Research from Chinanohttps://cassyni.com/events/TP7oLPbLZhffXJSatw87Uq?videoPreview=12023-11-29T09:00:00+00:003300.2Topics at the heart of our communityChina has been increasing investment into research and development for the past two decades, and Clarivate’s data now shows that China produces the highest number of citable documents globally (nearly twice as many as the USA). However, what has been less apparent is the quality of those papers. This month, we explore the scientific culture and impact of research from China, and show that the impact is now at least comparable to the USA and Europe across several disciplines. https://cassyni-user-files-prod.s3.amazonaws.com/WcVHuWHW4o3ifGfepqQSi https://cassyni.com/events/WM33j7zNbov2Nvft9q3SfF/seminar/qa https://cassyni.com/slides/outline/WM33j7zNbov2Nvft9q3SfF https://cassyni.com/events/WM33j7zNbov2Nvft9q3SfF/abstract https://cassyni-user-files-prod.s3.amazonaws.com/WQz29mPHCGBWmwHdbCGyBt https://cassyni.com/events/WM33j7zNbov2Nvft9q3SfF?videoPreview=1 Potentially singular behavior of 3D incompressible Navier-Stokes equationsnohttps://cassyni.com/events/WM33j7zNbov2Nvft9q3SfF?videoPreview=12023-12-01T16:00:00+00:003749.2Journal of Mathematical Fluid MechanicsWhether the 3D incompressible Navier-Stokes equations can develop a finite time singularity from smooth initial data is one of the most challenging problems in nonlinear PDEs. In this talk, I will present some new numerical evidence that the 3D Navier-Stokes equations develop nearly self-similar singular scaling properties with maximum vorticity increased by a factor of $10^7$. This potentially singular behavior is induced by a potential finite time singularity of the 3D Euler equations. Unlike the Hou-Luo blowup scenario, the potential singularity of the 3D Euler and Navier-Stokes equations occurs at the origin. We have applied several blowup criteria to study the potentially singular behavior of the Navier-Stokes equations. The Beale-Kato-Majda blow-up criterion, the blowup criteria based on the growth of enstrophy and negative pressure, the Ladyzhenskaya-Prodi-Serrin regularity criteria all seem to imply that the Navier-Stokes equations develop nearly singular behavior. Finally, we present some new numerical evidence that a class of generalized axisymmetric Navier-Stokes equations with time dependent fractional dimension and nonlinear rotation force seem to develop asymptotically self-similar blowup.https://cassyni-user-files-prod.s3.amazonaws.com/WQz29mPHCGBWmwHdbCGyBt https://cassyni.com/slides/outline/MTPo1Srp6vsaLeCG2ogqxq https://cassyni.com/events/MTPo1Srp6vsaLeCG2ogqxq/abstract https://cassyni-user-files-prod.s3.amazonaws.com/KVhb3Dkh2HPLFTwdJCGRaW https://cassyni.com/events/MTPo1Srp6vsaLeCG2ogqxq?videoPreview=1 Interactions between lee waves and vortices: numerical simulations and laboratory experimentsnohttps://cassyni.com/events/MTPo1Srp6vsaLeCG2ogqxq?videoPreview=12022-02-03T12:00:00+00:003194.64Leeds Institute for Fluid DynamicsNo abstracthttps://cassyni-user-files-prod.s3.amazonaws.com/KVhb3Dkh2HPLFTwdJCGRaW https://cassyni.com/events/LU6av5ZmE1mRftNFvqDX9w/seminar/qa https://cassyni.com/slides/outline/LU6av5ZmE1mRftNFvqDX9w https://cassyni.com/events/LU6av5ZmE1mRftNFvqDX9w/abstract https://cassyni-user-files-prod.s3.amazonaws.com/ExTQ7BtjYPWiJLU4K5Av14 https://cassyni.com/events/LU6av5ZmE1mRftNFvqDX9w?videoPreview=1 The use of social media in assessing the impact of war on cetaceansnohttps://cassyni.com/events/LU6av5ZmE1mRftNFvqDX9w?videoPreview=12023-12-08T10:00:00+00:003502.76Royal Society PublishingWar has always brought millions of silent non-human victims but the scale of this suffering is often either unknown, neglected or difficult to quantify. Further, the complexities associated with long-term and large-scale monitoring of marine species make it difficult to assess the impacts of war and the mortality of cetaceans resulting from warfare has not been investigated. Here we propose the use of a modified form of citizen science, namely gathering the information from social media. Dolphin stranding is such a poignant incident for most people, that the probability of eyewitness posting information on social media appears high. We test this idea by collecting data on cetacean strandings along the Black Sea published on the Internet over the three months of Russia's invasion of Ukraine in 2022. We also validate this method with a small-scale scientific study on cetacean mortality during the same period of time, conducted in ‘Tuzlivski lymany’ Nature National Park in Ukraine. Our dual approach has produced similar results, indicating a dramatic increase in cetacean mortality due to war operations in the Black Sea. We advocate the future use of social media to bridge the knowledge gap on the impacts of war on animals, in particular cetaceans.https://cassyni-user-files-prod.s3.amazonaws.com/ExTQ7BtjYPWiJLU4K5Av14 https://cassyni.com/slides/outline/TspecLGdot5GATtiti5FZw https://cassyni.com/events/TspecLGdot5GATtiti5FZw/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Re3NLqqHcTUr7jcrsi3Hiv https://cassyni.com/events/TspecLGdot5GATtiti5FZw?videoPreview=1 Two-scale homogenisation of high-contrast subwavelength resonances and error analysisnohttps://cassyni.com/events/TspecLGdot5GATtiti5FZw?videoPreview=12024-02-06T14:00:00+00:004298.08MetaMATHigh-contrast two-scale homogenization is a field with several decades of history. In the context of wave propagation, the critical scaling between the two small parameters of the spatial scale separation and contrast appears to be a micro-resonant scaling. Renewed interest to this area in the context of metamaterial modelling seems to be due to the two-scale asymptotic models’ ability to display often unusual macroscopic physical effects in an asymptotically explicit way, clarifying the nature and the microscopic mechanism of the observable effects such as band gap opening due to the subwavelength resonances. We give a brief background overview and discuss various scenarios displaying interesting effects. Finally, we report on most recent progress on constructing improved approximations of a two-scale type with controllably small errors for a broad and growing set of models of physical interest, see [1], joint work with Shane Cooper and Ilia Kamotski. https://cassyni-user-files-prod.s3.amazonaws.com/Re3NLqqHcTUr7jcrsi3Hiv https://cassyni.com/events/JzBPtf95K12p8BR6mgiesX/seminar/qa https://cassyni.com/slides/outline/JzBPtf95K12p8BR6mgiesX https://cassyni.com/events/JzBPtf95K12p8BR6mgiesX/abstract https://cassyni-user-files-prod.s3.amazonaws.com/JD7ag6jjssJsAxMfwBHxxE https://cassyni.com/events/JzBPtf95K12p8BR6mgiesX?videoPreview=1 An update on the 12 Labours DigitalTWINS platform for supporting clinical translation of computational physiology workflowsnohttps://cassyni.com/events/JzBPtf95K12p8BR6mgiesX?videoPreview=12024-03-05T23:00:00+00:003464.96Auckland Bioengineering InstituteThis seminar will present our latest efforts towards developing a Physiome modelling platform for precision medicine - the 12 Labours DigitalTWINS platform (Digital Translational Workflows for INtegrating Systems). We are building this platform to support clinical translation of computational physiology workflows and the development of personalised digital twins of patients. We will describe how we are storing data within the platform using a FAIR data management system and the FHIR clinical standard for 12 Labours exemplar projects. These include workflows for diagnosis of breast cancer and pulmonary hypertension. We also present efforts towards creating a unified clinical data management plan that can be used by researchers in their ethics applications. These efforts aim to maximise the secondary use and linking of data, which is essential for integrating workflows being developed by different research groups to create integrated virtual human twins.https://cassyni-user-files-prod.s3.amazonaws.com/JD7ag6jjssJsAxMfwBHxxE https://cassyni.com/events/5A2UbX2P2BXLUzxPs1NF8h/abstract https://cassyni-user-files-prod.s3.amazonaws.com/AU5t7SVMP3rNd3GTBoHyr6 https://cassyni.com/events/7dGVpwG1DUHpqwRxQhGsrd/abstract https://cassyni-user-files-prod.s3.amazonaws.com/88ZiRnULMLk5Des8yEN9H8 https://cassyni.com/events/9brv1fr6yJWaweiBmf8pHB/abstract https://cassyni-user-files-prod.s3.amazonaws.com/TaqRS94XFoFSGGAvTM2FdQ https://cassyni.com/events/MxYc7TnHnt6oK9Cydq3ivh/seminar/qa https://cassyni.com/slides/outline/MxYc7TnHnt6oK9Cydq3ivh https://cassyni.com/events/MxYc7TnHnt6oK9Cydq3ivh/abstract https://cassyni-user-files-prod.s3.amazonaws.com/5CMTNnEAXiVoAYXWdG27ug https://cassyni.com/events/MxYc7TnHnt6oK9Cydq3ivh?videoPreview=1 Understanding the micro-world of particle-to-particle interactionsnohttps://cassyni.com/events/MxYc7TnHnt6oK9Cydq3ivh?videoPreview=12024-03-27T11:00:00+00:005750.84Granular MatterContact modeling of particle-to-particle interactions has its own value in the simulation process and the understanding of macroscopic phenomena such as sand dunes, landslides, vibrating granular systems and other problems involving powders and grains. However, the real contact problem of particle interactions, let it be natural crystalline grains or amorphous glass beads, has been highly overlooked by means of experimentation. In this seminar, we will look into this contact problem and specifically on the way particles interact with each other and with their surrounding environment through an experimental approach. We will discuss on the influence of stress history, rate of loading and creep, and predominantly we will see pairs of particles within a general context of Coulomb friction. It will also be attempted to link micro- and macroscopic observations from experimental results on granular systems.https://cassyni-user-files-prod.s3.amazonaws.com/5CMTNnEAXiVoAYXWdG27ug https://cassyni.com/slides/outline/H24ZedK3QJZmv3VddMLjCZ https://cassyni.com/events/H24ZedK3QJZmv3VddMLjCZ/abstract https://cassyni-user-files-prod.s3.amazonaws.com/6BwvY4AAkWgetG9Fs4xTsU https://cassyni.com/events/H24ZedK3QJZmv3VddMLjCZ?videoPreview=1 Is competitive ability the key adaptation to benign environments? Revisiting experiments on closely related species of tidal plantsnohttps://cassyni.com/events/H24ZedK3QJZmv3VddMLjCZ?videoPreview=12024-05-01T12:00:00+00:001316.64Royal Society PublishingA central goal in biology is to understand which traits underlie adaptation to different environments. Yet, few studies have examined the relative contribution of competitive ability towards adaptive divergence among species occupying distinct environments. Here we test the relative importance of competitive ability as an adaptation to relatively benign versus challenging environments, using previous, published studies of closely related species pairs of primarily tidal plants subjected to reciprocal removal with transplant experiments in nature. Subordinate species typically occupy more challenging environments and showed consistent evidence for adaptation to challenging conditions, with no significant competitive effect on nonlocal, dominant species. In contrast, dominant species typically occupy relatively benign environments, and performed significantly better than nonlocal, subordinate species that faced competition from the dominant species. Surprisingly, when the two species were not allowed to compete, subordinate species performed as well as the dominant species in the benign environments where the subordinate species does not occur. These results suggest that competitive ability is the most important adaptation distinguishing the species that occupy relatively benign environments. The limited scope and number of suitable experimental studies encourage future work to test if these results are generalizable across taxa and environments.https://cassyni-user-files-prod.s3.amazonaws.com/6BwvY4AAkWgetG9Fs4xTsU https://cassyni.com/events/KVJat3YfbbLGGyyCB3FMvV/seminar/qa https://cassyni.com/slides/outline/KVJat3YfbbLGGyyCB3FMvV https://cassyni.com/events/KVJat3YfbbLGGyyCB3FMvV/abstract https://cassyni-user-files-prod.s3.amazonaws.com/WsnpCRTW8EufE582pHPpLe https://cassyni.com/events/KVJat3YfbbLGGyyCB3FMvV?videoPreview=1 Computational Modeling of Multiphysics Problems in Granular Medianohttps://cassyni.com/events/KVJat3YfbbLGGyyCB3FMvV?videoPreview=12024-04-26T12:00:00+00:004609.48Granular MatterThis talk addresses the emerging challenges of numerical modeling of granular media, specifically those involving multiphysics problems related to contemporary climate change and energy crises. Three examples are used to demonstrate key computational elements in addressing relevant challenges, including the free-thaw of frozen permafrost, the transport, deposition, and mitigation of geophysical flows, and laser powder-bed fusion in additive manufacturing. We emphasize the importance of considering the multiscale nature of these processes, from continuum-scale governing equations to particle and pore scale characteristics, to accurately capture and understand the underlying mechanisms for providing pertinent solutions to engineering problems of varied complexity. We also discuss pending issues related to computational granular mechanics as a whole.https://cassyni-user-files-prod.s3.amazonaws.com/WsnpCRTW8EufE582pHPpLe https://cassyni.com/events/Su2eaJFYBTe6mZVf8v76LV/seminar/qa https://cassyni.com/slides/outline/Su2eaJFYBTe6mZVf8v76LV https://cassyni.com/events/Su2eaJFYBTe6mZVf8v76LV/abstract https://cassyni-user-files-prod.s3.amazonaws.com/MrRC9qjC8P3T2a9abxnbka https://cassyni.com/events/Su2eaJFYBTe6mZVf8v76LV?videoPreview=1 Why do dogs wag their tails?nohttps://cassyni.com/events/Su2eaJFYBTe6mZVf8v76LV?videoPreview=12024-06-26T16:00:00+00:002826.88Royal Society PublishingHave you ever wondered: “Why do dogs wag their tails and why do humans like it?" Domestic dogs may be "man's best friend": one-third of all households worldwide own one and our coexistence began around 35,000 years ago. However, many dog behaviours remain a scientific enigma. The rhythmic tail wagging of domestic dogs has always caught our attention. Through our intuition and a handful of scientific studies, we have attributed different meanings to this behaviour, leading to fragmented and conflicting answers. Here, we summarise existing research on the mechanisms, development, evolution and function of tail wagging in domestic dogs, highlighting where the results converge, diverge or do not exist. We propose investigating this behaviour from its evolutionary roots and we suggest two hypotheses to explain its increased occurrence and frequency in dogs compared to other canids. This behaviour could have arisen during the domestication process following two paths: a) as a by-product of selection for other traits, such as docility, or b) as a trait directly selected by humans who are attracted to repetitive and rhythmic movements. We invite testing these hypotheses through neuro-cognitive studies on both dogs and humans, thus shedding light not only on a key canine behavior but also on the evolutionary history of characteristic human traits, such as the propensity for rhythm.https://cassyni-user-files-prod.s3.amazonaws.com/MrRC9qjC8P3T2a9abxnbka https://cassyni.com/events/YLBvCStCQrewz8CWwVw4Eq/seminar/qa https://cassyni.com/slides/outline/YLBvCStCQrewz8CWwVw4Eq https://cassyni.com/events/YLBvCStCQrewz8CWwVw4Eq/abstract https://cassyni-user-files-prod.s3.amazonaws.com/MXBMs6eDssN4CGbuArbCzi https://cassyni.com/events/YLBvCStCQrewz8CWwVw4Eq?videoPreview=1 On BOS and its progenitor, the Background-Distortion Schlieren Techniquenohttps://cassyni.com/events/YLBvCStCQrewz8CWwVw4Eq?videoPreview=12024-10-22T14:00:00+00:003523.24Experiments in FluidsMy twin goals for this half hour are to describe a few unique aspects of the BOS technique that I have observed over 20 years of playing with it, and hopefully to raise your awareness of the close kinship between BOS and the much-older background-distortion schlieren technique from which it came; a relationship that I suspect many are not even aware of. This requires no heavy math but is conveyed, instead, mostly by examining schlieren images. BOS is simple and easy to use, which is its greatest advantage, but that simplicity also conveys disadvantages, particularly non-parallel illumination and a sharp focus on the background rather than on the schlieren object. A second great advantage of BOS is its ability to image large fields-of-view without expensive optics, and a third is its adaptability to outdoor use. Background-distortion schlieren, first discovered by Robert Hooke over 350 years ago, is now taken so much for granted that it usually goes nameless, or is simply referred to by terms such as “backlighting”. BOS and background-distortion schlieren share almost the same simple optical diagram, but while BOS necessarily focuses on a background pattern, background distortion schlieren focuses instead on the phenomenon under study with defocused background. Examples are drawn from nature and common experience, and include many experiments on multiphase flows such as drops and bubbles, where there are large differences in refractive index between the phases. A few simple guidelines help one to obtain both useful and attractive background-distortion schlieren images. Finally, a popular modern do-it-yourself macro-photography technique, sometimes called “oil and water photography,” is revealed to be a kitchen-table version of the ancient background-distortion schlieren method. https://cassyni-user-files-prod.s3.amazonaws.com/MXBMs6eDssN4CGbuArbCzi https://cassyni.com/events/DZYxSUJFjTcSwr2U2Lsems/abstract https://cassyni-user-files-prod.s3.amazonaws.com/GbRQVU39d5zH6JF7rw1MQS https://cassyni.com/events/CaFkM71CrYWJH6CTvNQKxy/abstract https://cassyni-user-files-prod.s3.amazonaws.com/LZ7CDMf8YHFW4pHtc1ywjc https://cassyni.com/events/WrGjB2TWVqvLSRFMnMSBxR/seminar/qa https://cassyni.com/slides/outline/WrGjB2TWVqvLSRFMnMSBxR https://cassyni.com/events/WrGjB2TWVqvLSRFMnMSBxR/abstract https://cassyni-user-files-prod.s3.amazonaws.com/LKUZkk2fLBPhczN5v2DcrA https://cassyni.com/events/WrGjB2TWVqvLSRFMnMSBxR?videoPreview=1 Overhauling the American Prison Industry: A View From 20 Years of Incarcerationnohttps://cassyni.com/events/WrGjB2TWVqvLSRFMnMSBxR?videoPreview=12024-11-14T17:00:00+00:003339.04Lived Places PublishingBased on letters written during his twenty years of incarceration, Maurice Tyree introduces both the problems of and solutions to the disaster that is the American carceral state. Touching on the effects of family and environment, the education system, and anti-Blackness, Tyree will offer up his thoughts on overhauling the prison industry, so those who leave prison can actually become assets to both themselves and their community. This conversation is led by Chris McAuley, Black Studies Collection Editor at Lived Places Publishing and includes Tyree's co-author Katie Singer. Together, they wrote [The Darkest Parts of my Blackness: A Journey of Remorse, Reform, Reconciliation, and (R)evolution](https://livedplacespublishing.com/book/isbn/9781915734297?utm_source=MB&utm_medium=cassyni&utm_campaign=black-studies&utm_content=Tyree), published in August 2024. https://cassyni-user-files-prod.s3.amazonaws.com/LKUZkk2fLBPhczN5v2DcrA https://cassyni.com/slides/outline/3gcVdRseMfTrEoiqoM3jGZ https://cassyni.com/events/3gcVdRseMfTrEoiqoM3jGZ/abstract https://cassyni-user-files-prod.s3.amazonaws.com/XTipJa4LcZE3R3pD8DwV8A https://cassyni.com/events/3gcVdRseMfTrEoiqoM3jGZ?videoPreview=1 Evaluation of microbiome enrichment and host DNA depletion in human vaginal samples using Oxford Nanopore’s adaptive sequencingnohttps://cassyni.com/events/3gcVdRseMfTrEoiqoM3jGZ?videoPreview=12022-05-10T11:00:00+00:00680.0Microbiome Virtual International Forum Metagenomic sequencing is promising for clinical applications to study microbial composition concerning disease or patient outcomes. Alterations of the vaginal microbiome are associated with adverse pregnancy outcomes, like preterm premature rupture of membranes, and preterm birth. Methodologically these samples often have to deal with low relative amounts of prokaryotic DNA and high amounts of host DNA (higher than 90%), decreasing the overall microbial resolution. Nanopore’s adaptive sampling method offers selective DNA depletion or target enrichment to directly reject or accept DNA molecules during sequencing without specialized sample preparation.https://cassyni-user-files-prod.s3.amazonaws.com/XTipJa4LcZE3R3pD8DwV8A https://cassyni.com/slides/outline/J1Se5t9kVJTCNfwHREQqTs https://cassyni.com/events/J1Se5t9kVJTCNfwHREQqTs/abstract https://cassyni-user-files-prod.s3.amazonaws.com/g33dsSZoo9dnXfPzb6Hne https://cassyni.com/events/J1Se5t9kVJTCNfwHREQqTs?videoPreview=1 On-person ecology and evolution using high-resolution approachesnohttps://cassyni.com/events/J1Se5t9kVJTCNfwHREQqTs?videoPreview=12023-09-19T15:00:00+00:002128.08Microbiome Virtual International Forum No abstracthttps://cassyni-user-files-prod.s3.amazonaws.com/g33dsSZoo9dnXfPzb6Hne https://cassyni.com/events/TtQj1Z6FGTXXEBwJvoBCbo/seminar/qa https://cassyni.com/slides/outline/TtQj1Z6FGTXXEBwJvoBCbo https://cassyni.com/events/TtQj1Z6FGTXXEBwJvoBCbo/abstract https://cassyni-user-files-prod.s3.amazonaws.com/45LbsJW3os64YEVBfidAbx https://cassyni.com/events/TtQj1Z6FGTXXEBwJvoBCbo?videoPreview=1 Cosmological tensionsnohttps://cassyni.com/events/TtQj1Z6FGTXXEBwJvoBCbo?videoPreview=12024-10-16T12:30:00+00:003014.04Physics ReportsThe standard cosmological model has been extraordinarily successful in explaining a wealth of detailed data about the cosmic microwave background (CMB) and the galaxy distribution in the current Universe. The model requires, though, the introduction of some new form of matter to make up the dark matter and also some reason why the vacuum has a nonzero energy density. It also requires some new physics to explain the flatness of the early Universe and its primordial density perturbations. Finally, there has arisen, over the past decade, a discrepancy between the cosmological expansion rate inferred from the CMB and galaxy distribution and that obtained with local measurements. This "Hubble tension" is not easily resolved without the introduction of yet some more new physics. I will discuss these issues and some possible resolutions.https://cassyni-user-files-prod.s3.amazonaws.com/45LbsJW3os64YEVBfidAbx https://cassyni.com/slides/outline/JVPgGpv7rjr8PipMna8KDw https://cassyni.com/events/JVPgGpv7rjr8PipMna8KDw/abstract https://cassyni-user-files-prod.s3.amazonaws.com/QFDXDyMJwXpUpSAZJbyT5G https://cassyni.com/events/JVPgGpv7rjr8PipMna8KDw?videoPreview=1 Turbulence Closure Models: Reynolds Averaged Navier Stokes (RANS) & Large Eddy Simulations (LES)nohttps://cassyni.com/events/JVPgGpv7rjr8PipMna8KDw?videoPreview=12021-04-23T12:00:00+00:002013.0Brunton LabTurbulent fluid dynamics are often too complex to model every detail. Instead, we tend to model bulk quantities and low-resolution approximations. To remain physical, these reduced approximations of the Navier-Stokes equations must be 'closed', and turbulence closure modeling is one of the most important topics in high-performance computing and scientific computing. This video describes several leading approaches, including the Reynolds averaged Navier Stokes (RANS) equations and large eddy simulations (LES).https://cassyni-user-files-prod.s3.amazonaws.com/QFDXDyMJwXpUpSAZJbyT5G https://cassyni.com/slides/outline/Jz3HKWZeJCQBPVMFP1R7VF https://cassyni.com/events/Jz3HKWZeJCQBPVMFP1R7VF/abstract https://cassyni-user-files-prod.s3.amazonaws.com/KEPy3Z1h82hpjGo32CAUCW https://cassyni.com/events/Jz3HKWZeJCQBPVMFP1R7VF?videoPreview=1 DNS-based optimisation of airfoils for Martian helicopters using PyFRnohttps://cassyni.com/events/Jz3HKWZeJCQBPVMFP1R7VF?videoPreview=12023-06-22T14:00:00+00:001997.76PyFRThe Martian atmosphere has a lower density and lower speed of sound compared to Earth. These conditions require Martian rotor blades to operate in a low-Reynolds-number (1,000 to 10,000 based on chord) compressible regime, that is atypical for terrestrial helicopters. Non-conventional airfoils with sharp leading edges and flat surfaces have shown improved performance under such conditions, and second-order accurate Reynolds-Averaged Navier-Stokes (RANS) and Unsteady RANS (URANS) solvers have been combined with Genetic Algorithms to optimize such airfoils. However, flow over the airfoils is characterized by unsteady roll-up of coherent vortices, and transition to turbulence. Hence RANS/URANS solvers may have limited predictive capability, especially at higher angles of attack. The current study overcomes this limitation by undertaking optimization using high-order accurate Direct Numerical Simulations (DNS) via the compressible flow solver in PyFR. Specifically, a triangular airfoil is optimized at an angle of attack of $\alpha = 12^{\circ}$ with spanwise-periodic DNS. Multi-objective optimization is performed to maximize lift and minimize drag, yielding a Pareto front of non-dominated airfoils. Q-criterion isosurfaces, lift coefficient spectra, pressure coefficient distributions, velocity line integral convolutions and skin friction distributions are analyzed for airfoils on the Pareto front to elucidate the flow physics that yield optimal performance. The optimized airfoils achieve up to a 48\% increase in lift and a 28\% reduction in drag compared to a reference triangular airfoil previously tested experimentally in the Mars Wind Tunnel at Tohoku University. The work constitutes the first use of DNS for aerodynamic shape optimization. https://cassyni-user-files-prod.s3.amazonaws.com/KEPy3Z1h82hpjGo32CAUCW https://cassyni.com/slides/outline/VMeyHs9fWp2buzePQ7N1Am https://cassyni.com/events/VMeyHs9fWp2buzePQ7N1Am/abstract https://cassyni-user-files-prod.s3.amazonaws.com/2x9Za8WWoBvC7qxgVHf5nn https://cassyni.com/events/VMeyHs9fWp2buzePQ7N1Am?videoPreview=1 Decoding the Science of Modern Science and Coding its Managerial Implicationsnohttps://cassyni.com/events/VMeyHs9fWp2buzePQ7N1Am?videoPreview=12023-05-01T02:00:00+00:003836.56Department of MarketingModern science is based on two sciences: quantum science is the science of microscopic reality and relativity is the science of macroscopic reality. According to quantum science, there is a symmetry between the positive and the negative so that the energy within a subject continues to be zero unless the subject as a system interacts without itself. According to relativity, momentum present within an object discontinues the symmetry with its position as a subject. The energy within the subject changes from zero to one as the subject becomes an object of manipulation by another. One is present within oneness of the sequence of positions the entity takes with momentum over time. Postmodern science points to quantum relativity as the third science, the substitute that integrates both sciences to be the science of mesoscopic reality. Specifically, as the momentum becomes infinite, the subject becomes giant after gaining a finite mass. When the energy of another attracts it as an object, another becomes a supergiant with an infinite mass. Another is a zero who becomes one, letting another take its position as a zero. If there are several dimensions of reality and different sciences for explaining each dimension, how do we understand reality as a whole for its management using the lens of science? The criterion for substantiating the validity of science must be rigorous: every thesis must be substantiated with the empirically-verifiable quantified values grounded in simple, not complex, mathematics based on the assumptions guided by illusionary ideas and imaginary theories. My research decodes the reality beyond quantum relativity using a management lens for coding the implications of management science. https://cassyni-user-files-prod.s3.amazonaws.com/2x9Za8WWoBvC7qxgVHf5nn https://cassyni.com/slides/outline/Ru7jy5czSc9xtJLpkSz3dw https://cassyni.com/events/Ru7jy5czSc9xtJLpkSz3dw/abstract https://cassyni-user-files-prod.s3.amazonaws.com/8KttimAGUTuNQDdAWgLxcn https://cassyni.com/events/Ru7jy5czSc9xtJLpkSz3dw?videoPreview=1 From Rock-and-Roll to Sailing in the Rain via 47 Years of Fun in Medical Imagingnohttps://cassyni.com/events/Ru7jy5czSc9xtJLpkSz3dw?videoPreview=12023-02-28T03:00:00+00:004140.2The Auckland Bioengineering InstituteThis talk provides a personal tour from the early days of CT and quantitative 3D imaging, through to the application of imaging with machine learning to guide interventions and understand disease progression. I will describe how early applications of quantitative CT led to tissue characterisation in cancer, why spatial alignment of images became important and how this led to the advent of image guided interventions. Recent work in improving minimally invasive liver surgery and the management of prostate cancer demonstrates how these technologies have developed. The importance of a multiscale approach, understanding the cellular structure of disease, is enabling advances in prostate cancer diagnosis. Work in image guided lung radiotherapy led to work in chronic obstructive lung disease (COPD). Application of novel machine learning techniques, originally developed to understand the progression of Alzheimer’s disease, enables the study of COPD progression. The COVID pandemic provided opportunities to apply these ideas to better understand the progression of severe infectious disease. I have learnt that bringing together groups working in many disease areas allows cross fertilisation of ideas and methods, and at the same time provides challenges requiring novel engineering solutions. Establishing close links between healthcare providers, industry and academia promotes translation of these new ideas to the clinic. https://cassyni-user-files-prod.s3.amazonaws.com/8KttimAGUTuNQDdAWgLxcn https://cassyni.com/events/7d8PFngaCffC7FN721yLUM/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Rtj4xN1e3BRvvHJStrUD5Y https://cassyni.com/slides/outline/EYCquMjvM5Qyc4MgPTYGd3 https://cassyni.com/events/EYCquMjvM5Qyc4MgPTYGd3/abstract https://cassyni-user-files-prod.s3.amazonaws.com/LBTPqAgs1TBiXvhrjahbgr https://cassyni.com/events/EYCquMjvM5Qyc4MgPTYGd3?videoPreview=1 Anthromes, CO2 and Terrestrial Carbon – Session 2 (part 1): CO2 and land use change as drivers of terrestrial carbon dynamicsnohttps://cassyni.com/events/EYCquMjvM5Qyc4MgPTYGd3?videoPreview=12023-03-28T15:20:00+00:002028.56The New Phytologist Foundation11.20 - 11.50: Carbon emissions and uptake from land use and land cover changes – uncertainties and implications for the land carbon sink, Almut Arneth* (presenting remotely) 11.50 – 12.10: Carbon dynamics in mature forests under elevated CO2: Evidence from three contrasting forests, Rich Norby Due to technical difficulties, Almut's talk is not currently available.https://cassyni-user-files-prod.s3.amazonaws.com/LBTPqAgs1TBiXvhrjahbgr https://cassyni.com/slides/outline/MwxXiExgLJeYF7aYduLSff https://cassyni.com/events/MwxXiExgLJeYF7aYduLSff/abstract https://cassyni-user-files-prod.s3.amazonaws.com/PjN9GDYgBZS8r5ZcN6Fm1G https://cassyni.com/events/MwxXiExgLJeYF7aYduLSff?videoPreview=1 Electrostatics with Fluctuations, Correlations and Disordernohttps://cassyni.com/events/MwxXiExgLJeYF7aYduLSff?videoPreview=12021-10-21T09:00:00+00:004827.88Journal of Biological PhysicsElectric charges contribute significantly to the effective interactions between molecular constituents of life such as proteins, biopolymers and membranes. These interactions are mediated through aqueous ionic fluids. Even as macromolecular and other contact surfaces in the soft and biomatter contexts are often heterogeneously (or even randomly) charged, electrostatic theories rely primarily on textbook models with uniform (or regular) surface charge distributions. The ionic fluid is, on the other hand, treated within traditional mean-field frameworks such as the Poisson-Boltzmann theory. Mean-field theories ignore possible fluctuations and correlations produced in and by the surrounding ionic fluid. These effects can dominate in the presence of multivalent ions, where electrostatic couplings are strong and lead to remarkable and counterintuitive (non-mean-field) phenomena. The latter include formation of large bundles of like-charged biopolymers such as F-actin and microtubules and condensation of DNA in bulk and in viruses. In this talk, I will review the recent progress made in our understanding of how surface charge disorder and strong electrostatic couplings impact the effective interactions between charged objects. I will discuss how recent theoretical advances, supported by numerical and experimental findings, have led to a major paradigm shift in the electrostatic theory of charged systems, where likes can attract, opposites can repel and neutral (albeit randomly charged) objects can do both. When surface charge disorder and strong electrostatic correlations are both relevant, an otherwise standard electrical double layer can become antifragile and lose entropy upon increasing the disorder strength, even as the system becomes thermodynamically more stable.https://cassyni-user-files-prod.s3.amazonaws.com/PjN9GDYgBZS8r5ZcN6Fm1G https://cassyni.com/slides/outline/XpvcduuB7Tis6daa9U6oob https://cassyni.com/events/XpvcduuB7Tis6daa9U6oob/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Rb9jXVpU5quDgxitDyA4ei https://cassyni.com/events/XpvcduuB7Tis6daa9U6oob?videoPreview=1 Frontiers in plant–microbe interactions - part 2nohttps://cassyni.com/events/XpvcduuB7Tis6daa9U6oob?videoPreview=12023-06-15T08:00:00+00:004962.36New PhytologistWe present an exciting two-part webinar highlighting the latest research in plant–microbe interactions, hosted by Francis Martin. Following the recent publication of our collection on the ‘[Impact of global change on the plant microbiome ](https://nph.onlinelibrary.wiley.com/toc/14698137/2022/234/6)’, and ahead of the forthcoming special issue on '[Mycorrhizal research now: from micro-to macro scale](https://www.newphytologist.org/news/view/326)’, these webinars will explore the latest research on the fascinating and complex relationships between plants and microbes. Leading researchers will share their insights into the molecular mechanisms that underlie the symbiotic relationships between plants and different types of microbes, including nodulating bacteria, endophytes, and mycorrhizal fungi. Part 1 will be held on 13 June. This will be held on Zoom Webinar you can access the webinar here on Cassyni, or register on [Eventbrite](https://www.eventbrite.com/e/new-phytologist-now-frontiers-in-plant-microbe-interactions-part-2-registration-634787515547?aff=odcleoeventsincollection&keep_tld=1) to get the zoom link via email. https://cassyni-user-files-prod.s3.amazonaws.com/Rb9jXVpU5quDgxitDyA4ei https://cassyni.com/slides/outline/StSaB5RvitBqhXsE8zPp5T https://cassyni.com/events/StSaB5RvitBqhXsE8zPp5T/abstract https://cassyni-user-files-prod.s3.amazonaws.com/8JXYgJekY7QSPTqga4yNiJ https://cassyni.com/events/2C2Mru5gmzVtY5aVcmoiPo/abstract https://cassyni-user-files-prod.s3.amazonaws.com/D7xW3T69LVdS4Y6TyRE9qQ https://cassyni.com/events/2C2Mru5gmzVtY5aVcmoiPo?videoPreview=1 MWater reform — an evolving consensus?nohttps://cassyni.com/events/2C2Mru5gmzVtY5aVcmoiPo?videoPreview=12023-04-26T12:00:00+00:003935.44Stout Research Centre for New Zealand StudiesThe Land and Water Forum’s first report was completed in 2010, and its last in 2018. The current government handed the baton to the Freshwater Leaders Group and sought simultaneous advice from Kahui Wai Māori. In this session, Alastair and John will aim to answer the following questions: is there is an evolving consensus round water? What are its practical effects?https://cassyni-user-files-prod.s3.amazonaws.com/D7xW3T69LVdS4Y6TyRE9qQ https://cassyni.com/events/4fGP6KKJyHGNu244ATiM7j/seminar/qa https://cassyni.com/slides/outline/4fGP6KKJyHGNu244ATiM7j https://cassyni.com/events/4fGP6KKJyHGNu244ATiM7j/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Xv8hMQaDsnceZvZ5ci6xfG https://cassyni.com/events/4fGP6KKJyHGNu244ATiM7j?videoPreview=1 Session 7: U-HARWARD overviewnohttps://cassyni.com/events/4fGP6KKJyHGNu244ATiM7j?videoPreview=12023-10-06T12:00:00+00:007729.16Brahmal Vasudevan Institute for Sustainable Aviation at Imperial College LondonAn overview of the main outcomes of the [U-HARWARD](https://www.u-harward-project.eu) Ultra High Aspect Ratio Wing Advanced Research and Designs project, part of CleanSky2 program. The format of this session will be different than the previous ones. Talks 1, 3-5 be 20 min long and Talk 2 will be 40 min long, all including Q&A.https://cassyni-user-files-prod.s3.amazonaws.com/Xv8hMQaDsnceZvZ5ci6xfG https://cassyni.com/events/C4zSna2BZ9aDPbaX8La5Xj/abstract https://cassyni-user-files-prod.s3.amazonaws.com/MN91LoYCsnpM1HXY5hZF9Q https://cassyni.com/slides/outline/NSdksZ86B88N4t9uPr4k53 https://cassyni.com/events/NSdksZ86B88N4t9uPr4k53/abstract https://cassyni-user-files-prod.s3.amazonaws.com/9Gzx5KxCVd9b4yaGTParjp https://cassyni.com/events/NSdksZ86B88N4t9uPr4k53?videoPreview=1 The Davy Notebooks Projectnohttps://cassyni.com/events/NSdksZ86B88N4t9uPr4k53?videoPreview=12023-07-27T11:15:00+00:004635.68Royal Society PublishingSir Humphry Davy (1778-1829) was the foremost chemist of the early nineteenth century. He isolated more elements than any other individual has before or since, including calcium, magnesium, sodium, and potassium. He was the first person to inhale nitrous oxide, which subsequently become an important anaesthetic. His popular lectures at the Royal Institution of Great Britain brought him public fame. The miners’ safety lamp he invented, which became known as the ‘Davy lamp’, was used widely in mines in Britain and abroad. In 1820 he became President of the Royal Society. Davy is now well known as a bridging figure between the ‘two cultures’ of the arts and sciences. Davy’s scientific processes can be seen in 75 extant notebooks held at the Royal Institution and Kresen Kernow in Redruth, Cornwall's new archive centre. These manuscripts record critical scientific experiments; drafts of important lectures and publications; geological drawings; character portraits of Davy’s eminent scientific contemporaries; to-do lists, shopping lists, and autobiographical notes; references to Davy’s reading and contain a great deal of poetry. Notebook pages — torn, stained, and burned — reveal that Davy wrote poetry in his laboratory while at his scientific work. This event offers very short tasters of our special issue of the Notes and Records of the Royal Society will be the primary vehicle of disseminating the findings of our major AHRC-funded research project transcribing and annotating the complete set of Davy’s notebooks. The project brings together leading scholars in a number of fields: History of Science, English Literature, Colonialism and Empire, and Digital Humanities. The notebooks have never been transcribed in their entirety before and made publicly available. Connections will be made between these and Davy’s letters, lectures, published works, as well as his chemistry, geology, and other scientific interests, and his life and career. [The Davy Notebooks Project](wp.lancs.ac.uk/davynotebooks), which first launched as a pilot project in 2019, is a crowdsourced transcription project funded by the Arts and Humanities Research Council. Using Zooniverse, the world’s largest and most popular platform for people-powered research, the project is gathering transcriptions of the foremost man of science of the early nineteenth century, Sir Humphry Davy (1778-1829). The transcriptions of Davy's 75 strong notebook collection, produced with the help of our volunteer community, will soon be published and made freely available to all on the Lancaster Digital Collections platform. In this event, held on Monday 24th July 2023, members of the Davy Notebooks team meet with some of our Zooniverse volunteer transcribers and ask them to reflect on their experiences of transcribing on the project and what they have got out of it! Five of our volunteers, Helen, Carrie, John, David and Carlene also present on their favourite page and discoveries, and we give a behind the scenes look at our digital edition of Davy’s notebooks on the Lancaster Digital Collections platform. With thanks to our Zooniverse volunteer transcribers who attended this event: Helen, Carrie, John, David, Carlene, Angela, Chloe With Professor Sharon Ruston, Lancaster University, Dr Ellie Bird, Lancaster University, Professor Frank James, UCL, Dr Samantha Blickhan, Zooniverse, Dr Andrew Lacey, Lancaster University, Dr Alexis Wolf, Lancaster University.https://cassyni-user-files-prod.s3.amazonaws.com/9Gzx5KxCVd9b4yaGTParjp https://cassyni.com/slides/outline/VrMpZopxkzSCZTgNMivUV3 https://cassyni.com/events/VrMpZopxkzSCZTgNMivUV3/abstract https://cassyni-user-files-prod.s3.amazonaws.com/F6YvEBgF6KqpkVGv1ZxG1k https://cassyni.com/events/VrMpZopxkzSCZTgNMivUV3?videoPreview=1 Landscapes of Glassnohttps://cassyni.com/events/VrMpZopxkzSCZTgNMivUV3?videoPreview=12022-11-17T12:00:00+00:004363.32Granular MatterIf cooled sufficiently quickly, the disorder of a liquid can be "quenched" or locked in place; the resulting amorphous solid is glass. Although it appears to be solid on human timescales, glass continues to creep due to thermal vibrations at the molecular scale. Consider now a pile of sand; it too is a disordered system, but the grains are too massive for such thermal effects to be relevant. Yet, soils in nature relentlessly creep, on hillslopes below the angle of repose. The unchallenged dogma is that this creep is driven by churning of soil by (bio)physical disturbances, and diffusion models based on this premise underpin virtually all landscape evolution models (LEMs). River-bed sediments also creep, at flows below the threshold of motion, though this has received far less attention. In this talk I focus on recent work from my group and others that examines the origins of granular creep in hillslope and river systems, and the consequences of these findings for landscape dynamics. Our observations reveal surprises for both geologists and physicists. First, gravity-driven granular creep occurs with minimal disturbance, with rates and styles comparable to field observations. Second, this creep shares deep similarities with the behavior of glass, suggesting that mechanical disturbance in granular systems plays a role akin to thermal fluctuations in molecular systems. Third, fluid-driven creep in bed-load systems has similar behavior to gravity-driven hillslope creep. In both cases this creep acts to "harden" the bed, by compaction and the creation of structures that resist motion. Thus, sediment beds maintain a memory of their history of forcing, that dictates the threshold for landsliding (hillslopes) or entrainment (rivers). I hope to get some ideas from the audience on where to go next!https://cassyni-user-files-prod.s3.amazonaws.com/F6YvEBgF6KqpkVGv1ZxG1k https://cassyni.com/slides/outline/87qEXjMsSr4nkiQ5ydXond https://cassyni.com/events/87qEXjMsSr4nkiQ5ydXond/abstract https://cassyni-user-files-prod.s3.amazonaws.com/AR2LKHChLzqCMdjjJRzYjx https://cassyni.com/events/87qEXjMsSr4nkiQ5ydXond?videoPreview=1 Drone Vision and Deep Learning for Infrastructure Inspectionnohttps://cassyni.com/events/87qEXjMsSr4nkiQ5ydXond?videoPreview=12022-01-13T12:30:00+00:002986.76Journal on Image and Video ProcessingNo abstracthttps://cassyni-user-files-prod.s3.amazonaws.com/AR2LKHChLzqCMdjjJRzYjx https://cassyni.com/events/DYxt3FUeGtABt7yszFmhk1/seminar/qa https://cassyni.com/slides/outline/DYxt3FUeGtABt7yszFmhk1 https://cassyni.com/events/DYxt3FUeGtABt7yszFmhk1/abstract https://cassyni-user-files-prod.s3.amazonaws.com/z2XPB26mrCjvXjnnDpGTg https://cassyni.com/events/DYxt3FUeGtABt7yszFmhk1?videoPreview=1 Results from The EPSRC Future Composites Manufacturing Research Hubnohttps://cassyni.com/events/DYxt3FUeGtABt7yszFmhk1?videoPreview=12023-12-06T16:00:00+00:004023.48Department of AeronauticsThe seminar gives an overview of the research projects and findings from the EPSRC Future Composites Manufacturing Research Hub, 2017- 2024. The Hub is a £10.3M grant with industrial and institutional commitments of £8.9M and £3.7M respectively and has funded 37 composites manufacturing projects at 16 UK universities, with support from 39 industrial partners. The Hub portfolio includes a wide range of projects, from 6 month Feasibility Studies, through 2 year Innovation Fellowships to 3 year multi-institution Core Projects in the fields of: * High rate deposition and rapid processing technologies. * Design for manufacture via validated simulation. * Multifunctional composites and integrated structures. * Inspection and in-process evaluation. * Recycling and reuse. The seminar will also highlight some of the industrial impact and outreach activities undertaken by the Hub over the last seven years.https://cassyni-user-files-prod.s3.amazonaws.com/z2XPB26mrCjvXjnnDpGTg https://cassyni.com/slides/outline/CZffwtBbPy43DN9stHJNw7 https://cassyni.com/events/CZffwtBbPy43DN9stHJNw7/abstract https://cassyni-user-files-prod.s3.amazonaws.com/SjzpDJotsZXHWFfD75aipE https://cassyni.com/events/CZffwtBbPy43DN9stHJNw7?videoPreview=1 General Probabilistic Theories: An Introductionnohttps://cassyni.com/events/CZffwtBbPy43DN9stHJNw7?videoPreview=12024-01-10T12:00:00+00:002586.88Physics ReportsWe introduce the framework of general probabilistic theories (GPTs for short). GPTs are a class of operational theories that generalize both finite-dimensional classical and quantum theory, but they also include other, more exotic theories, such as the boxworld theory containing Popescu–Rohrlich boxes. We provide in-depth explanations of the basic concepts and elements of the framework of GPTs, and we also prove several well-known results. The review is self-contained and it is meant to provide the reader with consistent introduction to GPTs. Our tools mainly include convex geometry, but we also introduce diagrammatic notation and we often express equations via diagrams.https://cassyni-user-files-prod.s3.amazonaws.com/SjzpDJotsZXHWFfD75aipE https://cassyni.com/slides/outline/KyRMkmQMPCHbrRNk8j6Yyj https://cassyni.com/events/KyRMkmQMPCHbrRNk8j6Yyj/abstract https://cassyni-user-files-prod.s3.amazonaws.com/EFbGw5NuXsmjSAzCsMtHan https://cassyni.com/events/KyRMkmQMPCHbrRNk8j6Yyj?videoPreview=1 Introducing Transformative Plant Biotechnology: Developing Synthetic Biology Tools for Plant Genetic Engineering and Safe Plant Biodesignnohttps://cassyni.com/events/KyRMkmQMPCHbrRNk8j6Yyj?videoPreview=12023-09-21T08:30:00+00:001596.56The New Phytologist FoundationPlant biotechnology has been playing a more and more important role in plant genetic improvement for sustainable production of food, bioenergy and biomaterials. Synthetic biology holds great potential for transforming plant biotechnology research. Recently we developed multiple synthetic biology tools to facilitate plant transformation, multigene stacking, genome editing, and safe biosystems design. Specifically, we adopted a UV-visible green fluorescent protein (GFP) marker for early in vivo screening of transgenic events and real-time tracking of transgenic plants. In general, complex plant traits are controlled by multiple genes. The ability to stack multiple genes in plants is of great importance in the development of crops with desirable traits but can be challenging due to limited selectable marker options. To address this limitation, we developed a split selectable marker system based on protein splicing elements called “inteins” for Agrobacterium-mediated co-transformation in plants. To facilitate the delivery of gene editing agents into plant cells, we created an intein-mediated split-Cas9 system. To expedite multiplexed CRISPR/Cas-based genome editing, we developed a new platform, called “PARA”, for the rapid assembly of gRNA arrays. For safe plant biodesign, we created plant-based biosensors for detecting CRISPR-mediated genome engineering. Also, we demonstrated that anti-CRISPR proteins were very efficient for inhibiting CRISPR/Cas9-based tools in multiple plant species, laying a foundation for the future application of anti-CRISPR proteins in tunable genome editing in plants.https://cassyni-user-files-prod.s3.amazonaws.com/EFbGw5NuXsmjSAzCsMtHan https://cassyni.com/slides/outline/RQZ1GHX8DENzypxY9MLSw7 https://cassyni.com/events/RQZ1GHX8DENzypxY9MLSw7/abstract https://cassyni-user-files-prod.s3.amazonaws.com/PKCBcEWN8FaXZLuazg9FmY https://cassyni.com/events/RQZ1GHX8DENzypxY9MLSw7?videoPreview=1 Installation of offshore wind turbines: challenges and opportunitiesnohttps://cassyni.com/events/RQZ1GHX8DENzypxY9MLSw7?videoPreview=12021-11-11T12:00:00+00:003000.28Discover Applied SciencesDr. Zhiyu Jiang discusses Installation of offshore wind turbines: challenges and opportunities.https://cassyni-user-files-prod.s3.amazonaws.com/PKCBcEWN8FaXZLuazg9FmY https://cassyni.com/slides/outline/69GSTdHf6Nn8DEv3E3k9Eu https://cassyni.com/events/69GSTdHf6Nn8DEv3E3k9Eu/abstract https://cassyni-user-files-prod.s3.amazonaws.com/QfybV7Y4LG6qqHENK1HS3g https://cassyni.com/events/69GSTdHf6Nn8DEv3E3k9Eu?videoPreview=1 The Hawaiian Koʻa Card: coral health and bleaching assessment color reference card for Hawaiian coralsnohttps://cassyni.com/events/69GSTdHf6Nn8DEv3E3k9Eu?videoPreview=12021-03-24T12:00:00+00:003350.08Discover Applied SciencesCoral reefs are the foundation to our social, cultural, and economic life; however, reefs around the world are currently being threatened by many local and global impacts. Ongoing increases in seawater temperature pose significant threats to the integrity of these valuable ecosystems through extensive coral bleaching events. Therefore, we developed a coral health reference card, the Hawaiian Koʻa (coral) Card, to assess and quantify coral bleaching and to educate the community about its impacts in Hawai‘i. To accurately quantify the change in coral color during bleaching, controlled laboratory studies followed by field validations and surveys were conducted. Colors presented on the Hawaiian Koʻa Card have been linked to physiological state and health (e.g., symbiont density, chlorophyll levels, photosynthetic performance) of common coral species in Hawaiʻi due to bleaching. The Hawaiian Koʻa Card provides a technical solution to inform and improve management of our nearshore resources through collaborative monitoring efforts by community members, educators, researchers, and managers on a state-wide scale, which will assist in determining management efficacy, identifying regions and species of resilience, establishing baselines and focus areas, and developing and executing rapid response plans.https://cassyni-user-files-prod.s3.amazonaws.com/QfybV7Y4LG6qqHENK1HS3g https://cassyni.com/events/CnPznpQhoF6p9ChDa39Wm/abstract https://cassyni-user-files-prod.s3.amazonaws.com/7nghbfPg3xfceF73QzNYVt https://cassyni.com/slides/outline/B5kUvTkuUxKRffCij8oWeh https://cassyni.com/events/B5kUvTkuUxKRffCij8oWeh/abstract https://cassyni-user-files-prod.s3.amazonaws.com/QgWS2Q3hdbCQV4JXZSZgaS https://cassyni.com/events/B5kUvTkuUxKRffCij8oWeh?videoPreview=1 Dissipative Particle Dynamics for Surfactant Solutionsnohttps://cassyni.com/events/B5kUvTkuUxKRffCij8oWeh?videoPreview=12021-04-21T14:20:00+00:001148.0Leeds Institute for Fluid DynamicsSurfactants are present in many everyday products such as detergents, sham-poos, paints, and foods. Because of the amphiphilic nature of surfactant molecules, they self-assemble into lyotropic liquid crystal structures when in solution. There exists a wide range of possible solution phase structures, e.g. micellar, hexagonal, lamellar, etc, de-pending on the solution composition. The structure of these phases leads to distinct phase dependent rheologies. The rheology can be very difficult to predict numerically, and therefore is often measured experimentally for such systems. The specific surfactants to be studied in this work are alkyl ethoxysulfates (AES). These anionic surfactants are one of the most common components of personal care products. Small scale model-ling of the ‘clustering’ behaviour of surfactant molecules in solution helps us to under-stand the effects of the phase structure on the rheology of the material. Multiple simulation methods are possible for this type of investigation, but this talk will focus on the use of Dissipative Particle Dynamics (DPD). DPD is an off-lattice, mesoscopic simulation technique which involves a set of particles moving in continuous space. While similar, DPD has benefits over Molecular Dynamics (MD) techniques. In comparison, it has the potential for reaching longer length and time scales than MD. This makes DPD an ideal simulation method for such systems, as MD methods struggle to capture the self-assembly process of surfactant molecules, due to the long time scales involved. Most existing DPD research focuses on understanding equilibrium behaviour. However, the complex behaviour of surfactant solutions under shear flow is not well under-stood. Studying surfactant solutions via the DPD method allows us to investigate phase or structural changes that are induced in the fluid, as a result of applied shear. For example, when studying the micellar phase under increasing shear using DPD, we can show that micelles transform from spheres to worm like micelles forming in the direction of applied shear. How structural properties, such as the Radius of Gyration, are influenced by application of shear help us to understand these phase changes on a molecular level. This talk will also present how DPD can be used to calculate the shear viscosity of a fluid, along with the challenges in calculating such properties. The viscosities calculated can be compared with those found experimentally, in order to see if DPD is a viable method for predicting the viscosities of such systems.https://cassyni-user-files-prod.s3.amazonaws.com/QgWS2Q3hdbCQV4JXZSZgaS https://cassyni.com/slides/outline/6dwfcwT4wCFx2huZ29s7R7 https://cassyni.com/events/6dwfcwT4wCFx2huZ29s7R7/abstract https://cassyni-user-files-prod.s3.amazonaws.com/7tMVsoXBSAcEd59NfRRbGr https://cassyni.com/events/6dwfcwT4wCFx2huZ29s7R7?videoPreview=1 Site-specific regulation of translation initiation through RNA modificationsnohttps://cassyni.com/events/6dwfcwT4wCFx2huZ29s7R7?videoPreview=12023-06-15T14:00:00+00:003189.6Center for Cancer TrainingThe Arango lab works to unravel the molecular mechanisms by which post-transcriptional modifications of RNA regulate mRNA processing, stability, and translation and how this interplay affects cell fate decisions in homeostasis and disease. With more than 150 ribonucleotide modifications in all classes of RNA, the epitranscriptome has become a crucial regulatory layer of gene expression regulation. Although the vast diversity of RNA modifications entails an immense regulatory potential, deciphering the epitranscriptome is an enormous scientific challenge. Yet, its decryption will reveal fundamental aspects of gene expression regulation during normal metabolism and disease, which can potentially be leveraged for therapeutic applications. This seminar will focus on our recent findings that acetylation of cytidines in RNA regulates translation in a position-specific manner and the Arango’s laboratory ongoing studies to determine the mechanisms by which the RNA acetyltransferase complexes promote cell proliferation and cancer growth.https://cassyni-user-files-prod.s3.amazonaws.com/7tMVsoXBSAcEd59NfRRbGr https://cassyni.com/slides/outline/E3fjKC9wX4ZnXHS1z2iqq7 https://cassyni.com/events/E3fjKC9wX4ZnXHS1z2iqq7/abstract https://cassyni-user-files-prod.s3.amazonaws.com/6PG4AmvQGR364TZZwE18qt https://cassyni.com/events/E3fjKC9wX4ZnXHS1z2iqq7?videoPreview=1 On direct and inverse Kolmogorov equations for purely jump-like Markov processes and their generalizationsnohttps://cassyni.com/events/E3fjKC9wX4ZnXHS1z2iqq7?videoPreview=12023-10-19T15:00:00+00:003659.12Journal of Mathematical SciencesIn the work “On analytical methods in probability theory” (1931), A.N. Kolmogorov, starting from the relations called Kolmogorov-Chapman equations, derived for transition probabilities of inhomogeneous stochastically defined systems, or, as is now commonly said, for inhomogeneous Markov random processes (in an expanded meaning), reverse and direct equations in the following three cases: (A) systems with a finite number of states (B) systems with countable number of states (C) diffusion-type systems with a continuous set of states The report, which is largely of a review nature, considers the cases (A), (B) and the purely jump case for a Markov process with a Borel state space. The report is based on joint work with E.A. Fainberg.https://cassyni-user-files-prod.s3.amazonaws.com/6PG4AmvQGR364TZZwE18qt https://cassyni.com/slides/outline/GWukYcPZiMLGtDuaXidUZ3 https://cassyni.com/events/GWukYcPZiMLGtDuaXidUZ3/abstract https://cassyni-user-files-prod.s3.amazonaws.com/2PokLNgbFgbuUSuij2i7DQ https://cassyni.com/events/GWukYcPZiMLGtDuaXidUZ3?videoPreview=1 Complex tidal flow interactions in stellar and planetary convective envelopesnohttps://cassyni.com/events/GWukYcPZiMLGtDuaXidUZ3?videoPreview=12023-05-12T11:00:00+00:003378.56UK Fluids NetworkIn close star/star or star/planet systems, tidal interactions are known to shape the orbital architecture of the system, and modify the star and planet spins. Most stars around which planets have been discovered are low-mass solar-type stars, and thus feature a magnetised and often differentially-rotating convective envelope, as is also expected in giant gaseous planets. The dissipation of tidal flows, and more specifically the dissipation of inertial waves (restored by the Coriolis acceleration) is of particular importance in the convective envelopes, especially in the early stages of the life of an exoplanetary system. In parallel, the non-linear self-interactions of inertial waves are able to trigger differential rotation in convective shells in the form of axisymmetric zonal flows. In turn, linear numerical studies have shown that differential rotation can strongly affect the properties of inertial waves, namely their propagation and the dissipation of their kinetic energy. In this context, I will present our recent results of (magneto-)hydrodynamical non-linear numerical simulations of tidally-forced inertial waves, in 3D spherical convective shells. The emerging zonal flow strength and structure largely depend on the viscosity, tidal forcing amplitude and frequency. When strong, these flows deeply modify tidal dissipation rates from prior linear predictions. Moreover, we also find evidences of strong wave/wave and wave/zonal flow interactions leading to parametric and shear flow instabilities due to correlation resonances (when the Doppler-shifted frequency vanishes). Therefore, I will discuss to what extent these various non-linear effects disrupt the linear predictions for tides along the permissible forcing frequency range and for various viscosities, tidal amplitudes and size of the convective shells which are representative of the convective envelopes of low-mass stars and giant gaseous planets.https://cassyni-user-files-prod.s3.amazonaws.com/2PokLNgbFgbuUSuij2i7DQ https://cassyni.com/slides/outline/97BgrMgh8V2m8BifyZ1r6y https://cassyni.com/events/97BgrMgh8V2m8BifyZ1r6y/abstract https://cassyni-user-files-prod.s3.amazonaws.com/8sehyApEK5iUeGVpbbgNeJ https://cassyni.com/events/97BgrMgh8V2m8BifyZ1r6y?videoPreview=1 HDAC3 is critical in tumor development and therapeutic resistance in Kras-mutant non-small cell lung cancernohttps://cassyni.com/events/97BgrMgh8V2m8BifyZ1r6y?videoPreview=12024-04-18T18:00:00+00:002342.2Center for Cancer TrainingHDAC3 is one of the main targets of histone deacetylase (HDAC) inhibitors in clinical development as cancer therapies, yet the in vivo role of HDAC3 in solid tumors is unknown. We identified a critical role for HDAC3 in Kras-mutant lung cancer. Using genetically engineered mouse models (GEMMs), we found that HDAC3 is required for lung tumor growth in vivo. HDAC3 was found to direct and enhance the transcription effects of the lung cancer lineage transcription factor NKX2-1 to mediate expression of a common set of target genes. We identified FGFR1 as a critical previously unidentified target of HDAC3. Leveraging this, we identified that an HDAC3-dependent transcriptional cassette becomes hyperactivated as Kras/LKB1-mutant cells develop resistance to the MEK inhibitor trametinib, and this can be reversed by treatment with the HDAC1/HDAC3 inhibitor entinostat. We found that the combination of entinostat plus trametinib treatment elicits therapeutic benefit in the Kras/LKB1 GEMM.https://cassyni-user-files-prod.s3.amazonaws.com/8sehyApEK5iUeGVpbbgNeJ https://cassyni.com/slides/outline/VMo5s1j6XcfEegiEnnfYZ3 https://cassyni.com/events/VMo5s1j6XcfEegiEnnfYZ3/abstract https://cassyni-user-files-prod.s3.amazonaws.com/8HLJeM3CVRDkzTANqdSoKk https://cassyni.com/events/VMo5s1j6XcfEegiEnnfYZ3?videoPreview=1 Generating realistic turbulent wakes from scaled rotors in the lab: inflow control, rainfall and Coriolis forcesnohttps://cassyni.com/events/VMo5s1j6XcfEegiEnnfYZ3?videoPreview=12024-02-28T16:00:00+00:002761.96Department of AeronauticsWithin a worldwide effort to increase alternative energies generation, the study of the flow downstream one or several wind turbines has captured the attention of the turbulence community for its complexity; it involves turbulent wakes, interactions between them and their coupling with the background turbulent flow. The main limiting factors to reproduce operating conditions in applications rely in the difficulties generating realistic conditions in experimental facilities. This seminar is divided in two parts. In the first one, we will focus specifically on the spatial development of the turbulent wake under different inflows. In a series of experiments performed at Oldenburg’s large wind tunnel, the near and far wake of a scaled wind turbine have been studied. The spatial evolution has been characterized for different Reynolds numbers, tip speed ratios and background flows (laminar and turbulent). The resulting database shows that, while the flow always evolves according to the classical Richardson-Kolmogorov scalings, operating conditions have a strong influence in the properties of the wake. For instance, they are related to the velocity deficit scalings and the streamwise extent of the production region of turbulence. In the second part we will discuss further efforts to achieve realistic conditions in experimental facilities. First, experiments using scaled rotors in a wind tunnel under rainfall conditions will be discussed. It has been found that rainfall influences the persistence of the wake, and that the rain droplets tend so segregate in clusters and voids within the far wake. Further, to assess mesoscale phenomena in the atmosphere, a rotating platform was used to assess the influence of Coriolis force in the large-scale wake generated by a wind farm. Such effects are becoming relevant as wind farms become larger, and the global wake they generate is characterised by Rossby numbers low enough to make the Coriolis force significant. Our experiments confirm that, while the wake of a single rotor does not experiences any deflection, the merged wind farm wake is deflected due to the effect of rotation.https://cassyni-user-files-prod.s3.amazonaws.com/8HLJeM3CVRDkzTANqdSoKk https://cassyni.com/events/RuFrYECRTQnbczQg98Hb2D/seminar/qa https://cassyni.com/events/RuFrYECRTQnbczQg98Hb2D/abstract https://cassyni-user-files-prod.s3.amazonaws.com/8aLBhd3aJdtKpveAsZJKeE https://cassyni.com/events/RuFrYECRTQnbczQg98Hb2D?videoPreview=1 Gender, Language, and Bilingualism - New Perspectives on the Processing of Gender Stereotypesnohttps://cassyni.com/events/RuFrYECRTQnbczQg98Hb2D?videoPreview=12024-03-12T23:00:00+00:002022.48Linguistics and Applied Language StudiesSimultaneous bilingual children have been found to show less racial bias than their monolingual peers (Singh et al., 2019; 2020), which was predicted by better cognitive flexibility (Singh et al., 2021). It raises the question whether this can also be found in young adults who are either simultaneous or sequential bilinguals, respectively, and whether other aspects of social cognition, such as gender stereotyping, can also be predicted by cognitive flexibility. To further investigate the relationship between cognitive flexibility, social cognition and the bilingual experience, we set up an English reading EEG experiment. We tested 66 university students who were either Dutch or Spanish L1 speakers. All were sequential English L2 speakers, and around half were, in addition, Dutch-Frisian (n = 16), or Spanish-Catalan (n = 14) simultaneous bilinguals. The stimuli were English sentences with pronouns as critical words (e.g., “The lifeguard threw himself into the water.”). The presentation will discuss the experiment setup, and first behavioural results. https://cassyni-user-files-prod.s3.amazonaws.com/8aLBhd3aJdtKpveAsZJKeE https://cassyni.com/slides/outline/UNVsmeS3ehZ5yvtEgpCDk9 https://cassyni.com/events/UNVsmeS3ehZ5yvtEgpCDk9/abstract https://cassyni-user-files-prod.s3.amazonaws.com/2C5u1qpt1pwjTy1jCbQxHk https://cassyni.com/events/UNVsmeS3ehZ5yvtEgpCDk9?videoPreview=1 Minimal Change Disease/Primary FSGS - New ways to look at an old diseasenohttps://cassyni.com/events/UNVsmeS3ehZ5yvtEgpCDk9?videoPreview=12022-01-05T15:00:00+00:004218.36Imperial College Renal and Transplant CentreNo abstracthttps://cassyni-user-files-prod.s3.amazonaws.com/2C5u1qpt1pwjTy1jCbQxHk https://cassyni.com/slides/outline/4AjGW9jL9GRBpF8Pm2tvKo https://cassyni.com/events/4AjGW9jL9GRBpF8Pm2tvKo/abstract https://cassyni-user-files-prod.s3.amazonaws.com/XWszvg6y341y11H5rV8yrn https://cassyni.com/events/4AjGW9jL9GRBpF8Pm2tvKo?videoPreview=1 Building a Data Fit Organisationnohttps://cassyni.com/events/4AjGW9jL9GRBpF8Pm2tvKo?videoPreview=12022-09-07T14:00:00+00:001290.04Data-Centric Engineering JournalEvidence of use of AI-models to inform and drive day-to-day decisions about industrial assets is sparse despite significant investment in platforms, processes and developing models. While employees understand their roles in safety, cost and production, expectations for their behaviours and responsibilities towards the data they generate, manipulate and use are not clear. This talk describes the Data Fit approach for industries involved in implementing AI to support decisions by engineers, scientists and technicians. The novelties of the Data Fit framework are a) data workflows, b) roles and behaviours for all involved (lead, enabler, consumer, composer, custodian and creator), and c) an explicit need for feedback loops. Development involved the observation of over 100 data work flows. Technical subject matter experts and their managers report that the Data Fit framework provides clarity about expectations for behaviours of all involved in the data workflows. This leads to improve process quality and enables more consistent delivery of business value through data.https://cassyni-user-files-prod.s3.amazonaws.com/XWszvg6y341y11H5rV8yrn https://cassyni.com/slides/outline/EYLxUWKMMt3cLkRXn8qp1K https://cassyni.com/events/EYLxUWKMMt3cLkRXn8qp1K/abstract https://cassyni-user-files-prod.s3.amazonaws.com/YFJFVH9L1JdC836xU6KFwk https://cassyni.com/events/EYLxUWKMMt3cLkRXn8qp1K?videoPreview=1 FuturePub London - International Women's Daynohttps://cassyni.com/events/EYLxUWKMMt3cLkRXn8qp1K?videoPreview=12024-03-04T18:00:00+00:003795.36#FuturePub is back in London for our first event of 2024 and, by popular demand, we are thrilled to be hosting this at the awesome ping ping club Bounce in Farringdon once again! The focus of this FuturePub is to create a platform for conversation around inclusion, from gender imbalance in research and tech to intersectional challenges faced by people across the world, and how a more diverse research workforce and tech designed with everyone in mind will ultimately lead us through some of the challenges we face as a global society and towards a better quality of life for all. Speakers for the evening will be announced soon but we have reserved a couple of slots in case YOU or someone you know would like to join our line-up. If you're interested in speaking at this #FuturePub, or a future #FuturePub, let us know by filling out [this short proposal form](https://forms.gle/rXwMCYMeFiqJsVKeA).https://cassyni-user-files-prod.s3.amazonaws.com/YFJFVH9L1JdC836xU6KFwk https://cassyni.com/events/XqWh38ina3B8AfD19Pp64d/abstract https://cassyni-user-files-prod.s3.amazonaws.com/SdhUXPUvhNG5RmF7fAEztv https://cassyni.com/events/2CcSG7uJEZx9c7CvchWzeq/seminar/qa https://cassyni.com/slides/outline/2CcSG7uJEZx9c7CvchWzeq https://cassyni.com/events/2CcSG7uJEZx9c7CvchWzeq/abstract https://cassyni-user-files-prod.s3.amazonaws.com/AZgNQ6VyQteQdKbKrfHX2n https://cassyni.com/events/4frTVY8vRridy3gVAPRdNm/seminar/qa https://cassyni.com/slides/outline/4frTVY8vRridy3gVAPRdNm https://cassyni.com/events/4frTVY8vRridy3gVAPRdNm/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Kv1a7qHB3kvyoK2BG1u2Ja https://cassyni.com/slides/outline/D4sjHA8qte8d8P2xEEkgbf https://cassyni.com/events/D4sjHA8qte8d8P2xEEkgbf/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Jb6pbEHd1f1aydKyQ1ujdG https://cassyni.com/events/D4sjHA8qte8d8P2xEEkgbf?videoPreview=1 Arousal as a universal embedding for spatiotemporal brain dynamicsnohttps://cassyni.com/events/D4sjHA8qte8d8P2xEEkgbf?videoPreview=12023-12-22T14:00:00+00:001522.72Brunton LabNeural activity in awake organisms shows widespread and spatiotemporally diverse correlations with behavioral and physiological measurements. We propose that this covariation reflects in part the dynamics of a unified, arousal-related process that regulates brain-wide physiology on the timescale of seconds. Taken together with theoretical foundations in dynamical systems, this interpretation leads us to a surprising prediction: that a single, scalar measurement of arousal (e.g., pupil diameter) should suffice to reconstruct the continuous evolution of multimodal, spatiotemporal measurements of large-scale brain physiology. To test this hypothesis, we perform multimodal, cortex-wide optical imaging and behavioral monitoring in awake mice. We demonstrate that spatiotemporal measurements of neuronal calcium, metabolism, and blood-oxygen can be accurately and parsimoniously modeled from a low-dimensional state-space reconstructed from the time history of pupil diameter. Extending this framework to behavioral and electrophysiological measurements from the Allen Brain Observatory, we demonstrate the ability to integrate diverse experimental data into a unified generative model via mappings from an intrinsic arousal manifold. Our results support the hypothesis that spontaneous, spatially structured fluctuations in brain-wide physiology—widely interpreted to reflect regionally-specific neural communication—are in large part reflections of an arousal-related process. This enriched view of arousal dynamics has broad implications for interpreting observations of brain, body, and behavior as measured across modalities, contexts, and scales.https://cassyni-user-files-prod.s3.amazonaws.com/Jb6pbEHd1f1aydKyQ1ujdG https://cassyni.com/slides/outline/FY7kWaNU5vu7VKWWmvfKKb https://cassyni.com/events/FY7kWaNU5vu7VKWWmvfKKb/abstract https://cassyni-user-files-prod.s3.amazonaws.com/RE5pWr3gdNQzUac2w4rgpe https://cassyni.com/events/FY7kWaNU5vu7VKWWmvfKKb?videoPreview=1 Symmetry-informed model inference for active matternohttps://cassyni.com/events/FY7kWaNU5vu7VKWWmvfKKb?videoPreview=12022-06-03T14:00:00+00:003993.08AI Institute in Dynamic SystemsConsider map F: U o V. Given data pairs {u_j,F(u_j)} the goal of supervised learning is to approximate F. Neural networks have shown considerable success in addressing this problem in settings where X is a finite dimensional Euclidean space and where Y is either a finite dimensional Euclidean space (regression) or a set of finite cardinality (classification). Motivated by the need for surrogate modeling (in, for example, Bayesian inversion) and by scientific discovery (in, for example, constitutive modeling) we focus on the design and analysis of algorithms which address supervised learning for settings where U and V comprise spaces of functions; thus F is an operator. The talk describes emerging methodology in this area, emerging theory which underpins the methodology and numerical experiments which elucidate the efficiency of different approaches. Various applications from continuum mechanics are described, including an inverse problem arising in incompressible fluid flow and constitutive modeling in viscoelasticity.https://cassyni-user-files-prod.s3.amazonaws.com/RE5pWr3gdNQzUac2w4rgpe https://cassyni.com/events/C5aXBnqo1j2UTdCx8GHMnm/abstract https://cassyni-user-files-prod.s3.amazonaws.com/7AL44XnV9bupgDgamHNXXL https://cassyni.com/slides/outline/NTDqGmwhdhad8cCVRwAh6u https://cassyni.com/events/NTDqGmwhdhad8cCVRwAh6u/abstract https://cassyni-user-files-prod.s3.amazonaws.com/4VhxtxCCD1u1RSuhTZTdnE https://cassyni.com/events/NTDqGmwhdhad8cCVRwAh6u?videoPreview=1 The impacts of saltwater intrusion and sea level rise on plant and microbial communities of coastal wetlandsnohttps://cassyni.com/events/NTDqGmwhdhad8cCVRwAh6u?videoPreview=12024-06-07T15:45:00+00:001099.08New Phytologist Foundation Coastal freshwater forested wetlands provide important ecosystem services, yet are threatened by saltwater intrusion and sea level rise (SWISLR). In these systems, SWISLR is leading to increased marine salt exposure, soil alkalinization, and inundation. Remote sensing has revealed that nearly 10% of forested wetlands in the North American coastal plain have transitioned to shrubland or marsh since 1996. Despite the scale and importance of these community shifts, how the multivariate effects of SWISLR impact plant and microbial community turnover and diversity remains unresolved. In this study, we investigate the drivers of plant and microbial community turnover, diversity, and forest loss. We established three transects representing space-for-time gradients of saltwater exposure in the Albemarle-Pamlico Peninsula of North Carolina, USA. Along each transect, we surveyed plant community composition and collected soil cores for sequencing fungal (ITS2) and bacterial (16S) community DNA and soil chemistry analysis. Using model selection, we identified the strongest drivers of community turnover and diversity. We found that changes in soil salinity and pH were the greatest drivers of understory plant community turnover, while tree biomass was best predicted by inundation. For microbial communities, we observed complex interactions between salinity, pH, and inundation driving community turnoverhttps://cassyni-user-files-prod.s3.amazonaws.com/4VhxtxCCD1u1RSuhTZTdnE https://cassyni.com/events/NwsSKTbE5A8g8NjP2NTVND/abstract https://cassyni-user-files-prod.s3.amazonaws.com/3zc6NhhtK2ixevnXusqSJa https://cassyni.com/slides/outline/Vrwty2eaDZtTdBixPp2RWu https://cassyni.com/events/Vrwty2eaDZtTdBixPp2RWu/abstract https://cassyni-user-files-prod.s3.amazonaws.com/P8DzvGz5uEXZzWgBeugiZc https://cassyni.com/events/Vrwty2eaDZtTdBixPp2RWu?videoPreview=1 Integrating Digital and AI Technologies into Mental Health: Lessons from a Four-Year SG-NZ Collaboration on Multi-Modal AI Models.nohttps://cassyni.com/events/Vrwty2eaDZtTdBixPp2RWu?videoPreview=12024-07-09T04:00:00+00:004436.68The Auckland Bioengineering InstituteThe LYRIKS dataset is a unique study on Singaporean youths at ultra-high risk of developing a spectrum of mental health disorders. Although the original study concluded over 13 years ago, we continue to uncover novel findings. This ongoing discovery is fuelled by the availability of new digitization modalities, including omics and natural language processing, as well as advanced AI technologies. Through a four-year project funded by Singapore and New Zealand, my team explored the potential of novel bio and digital markers, ranging from genes to text. We also developed various new feature selection techniques and innovative network-based models. I will present a selection of notable works from this collaboration. Implementing AI and digital technology in healthcare goes beyond creating models that excel in academic publications. Stakeholder engagement is critical. Clinicians, although receptive, have reservations. Developers, who play a crucial role in building AI models, seek greater involvement. It is also essential to address and include the perspectives of patients, the public, and minority groups. I will discuss some of our ongoing efforts to incorporate stakeholder perspectives to enable successful digital transformation. Finally, I would like to share some thoughts for future research. Specifically, using context to enhance data integration, how to connect digital phenotyping with earlier findings to enhance mental health monitoring and management. https://cassyni-user-files-prod.s3.amazonaws.com/P8DzvGz5uEXZzWgBeugiZc https://cassyni.com/events/2hHfRS4i5PRyRaCSQodxq3/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Fg1E99GLkSyzKnD49bLWaz https://cassyni.com/events/WMd88Loz4PNHSeiUBv9Ph7/abstract https://cassyni-user-files-prod.s3.amazonaws.com/UeASourVe3eUk1Qmasxnii https://cassyni.com/slides/outline/8d6Y6GLtkEzsduSBopkizh https://cassyni.com/events/8d6Y6GLtkEzsduSBopkizh/abstract https://cassyni-user-files-prod.s3.amazonaws.com/KrNdFzHxgrWWo5g4eGZucJ https://cassyni.com/events/8d6Y6GLtkEzsduSBopkizh?videoPreview=1 Persistent Changes in the Gut Microbiome of COVID-19 Survivorsnohttps://cassyni.com/events/8d6Y6GLtkEzsduSBopkizh?videoPreview=12021-12-08T13:00:00+00:00804.04Microbiome Virtual International Forum There are hundreds of millions of survivors of coronavirus disease 2019 (COVID-19), and this group continues to grow. Sars-CoV-2, the causative agent of COVID-19, is detectable in gastrointestinal secretions with measurable impact on the gut microbiome. Given reports that COVID-19 causes persistent symptoms in a majority of COVID survivors, we sought to understand the long-term effects of COVID-19 on the gut microbiome. We longitudinally sampled 18 individuals (n = 14 COVID positive and n = 4 COVID-19 negative household contacts) living in San Francisco. Consistent with prior reports, we detect an association between COVID-19 and the gut microbiome. COVID-19 survivors exhibited greater dispersion of the microbial community. COVID-19 survivors gut microbial communities were more self-distinct when compared to COVID-19 negative individuals. Population level social distancing practices varied during the time of sample collection in our cohort, and we found an unexpected association between population level social distancing and gut microbial community variation. Alpha diversity varied overtime in COVID-19 negative individuals. In contrast alpha diversity over time mirrored the effects observed in beta-dispersion in this group in COVID-19 positive individuals. We analyzed a separate cohort of healthy San Franciscans pre-pandemic where we observed similar variation in alpha diversity over time. We conclude that COVID-19 survivors exhibit greater dispersion of their microbial communities, which is a perturbation observable months after infection and potentially compounded by population level social distancing practices.https://cassyni-user-files-prod.s3.amazonaws.com/KrNdFzHxgrWWo5g4eGZucJ https://cassyni.com/slides/outline/DNUQ1e2ANhMssFHFf96Yd https://cassyni.com/events/DNUQ1e2ANhMssFHFf96Yd/abstract https://cassyni-user-files-prod.s3.amazonaws.com/4WmGeoQqLBLF5RsWqXn3hY https://cassyni.com/events/DNUQ1e2ANhMssFHFf96Yd?videoPreview=1 Topic models for interpretable multidomain microbiome datanohttps://cassyni.com/events/DNUQ1e2ANhMssFHFf96Yd?videoPreview=12022-02-08T10:00:00+00:001610.0Microbiome Virtual International Forum Data from sequencing bacterial communities are formalized as contingency tables whose columns correspond to different biological sample-specimens. The row-features are a random collection of Amplicon Sequence Variants (ASVs in the case of 16S rRNA type amplicon sequencing) or gene fragments (in the case of metagenomics). In both cases, these entities are defined after the data are collected, thus imposing a nonparametric framework. There are usually more features-rows than columns imposing necessary regularization through use of Bayesian priors. However, the classical Dirichlet-multinomial models are insufficient to account for the strong associations (or exclusions) between certain bacteria, thus recent hierarchical models such as latent Dirichlet topic models have provided a more flexible framework that allow mixed membership models more appropriate for these non-Gaussian data. We will show how these hierarchical topic models can enhance our understanding of both longitudinal dependencies between samples and biological dependencies between taxa, regardless of the differences in sampling depth and sources of variability. This contains work with Kris Sankaran, Pratheepa Jeganathan, Laura Symul, Ben Callahan, and David Relman.https://cassyni-user-files-prod.s3.amazonaws.com/4WmGeoQqLBLF5RsWqXn3hY https://cassyni.com/slides/outline/AbgxGzvzW5DdjciRAncfRF https://cassyni.com/events/AbgxGzvzW5DdjciRAncfRF/abstract https://cassyni-user-files-prod.s3.amazonaws.com/MTbL7jCxj31h9HVQVGszML https://cassyni.com/events/AbgxGzvzW5DdjciRAncfRF?videoPreview=1 Functional screens of barcoded expression libraries uncover new gene functions in carbon utilization among gut Bacteroidalesnohttps://cassyni.com/events/AbgxGzvzW5DdjciRAncfRF?videoPreview=12022-11-08T13:00:00+00:00560.04Microbiome Virtual International Forum A mechanistic understanding of host-microbe interactions in the gut microbiome is hindered by poorly annotated bacterial genomes. While functional genomics can generate large gene-to-phenotype datasets to accelerate gene discovery, their applications to study gut anaerobes have been limited. For instance, most gain-of-function screens of gut bacterial genes have been performed in an aerobic host and included a small number of conditions. To address these challenges, we developed a strategy to barcode expression libraries for high-throughput interrogation of gene functions in competitive fitness assays. We demonstrate the power of this approach to uncover novel phenotypes for uncharacterized genes using pooled libraries constructed from a diverse set of gut Bacteroidales expressed in Bacteroides thetaiotaomicron. We identified new roles in carbohydrate metabolism for nine proteins, including enzymes, transporters, a regulator, and hypothetical proteins from mobile genetic elements. This approach can be readily applied to other organisms and additional phenotypic assays. Link to OA paper: https://www.biorxiv.org/content/10.1101/2022.10.05.510937v1https://cassyni-user-files-prod.s3.amazonaws.com/MTbL7jCxj31h9HVQVGszML https://cassyni.com/slides/outline/MTysQfgRZWKqQNEr4tnnzh https://cassyni.com/events/MTysQfgRZWKqQNEr4tnnzh/abstract https://cassyni-user-files-prod.s3.amazonaws.com/F2tFNYeGzUZXLfq6vpkE8n https://cassyni.com/events/MTysQfgRZWKqQNEr4tnnzh?videoPreview=1 Data-driven prediction of colonization outcomes for complex microbial communitiesnohttps://cassyni.com/events/MTysQfgRZWKqQNEr4tnnzh?videoPreview=12024-04-17T14:00:00+00:00522.04Microbiome Virtual International Forum Microbial interactions can lead to different colonization outcomes of exogenous species, be they pathogenic or beneficial in nature. Predicting the colonization of exogenous species in complex communities remains a fundamental challenge in microbial ecology, mainly due to our limited knowledge of the diverse mechanisms governing microbial dynamics. Here, we propose a data-driven approach independent of any dynamics model to predict colonization outcomes of exogenous species from the baseline compositions of microbial communities. We systematically validate this approach using synthetic data, finding that machine learning models can predict not only the binary colonization outcome but also the post-invasion steady-state abundance of the invading species. Then we conduct colonization experiments for commensal gut bacteria species Enterococcus faecium and Akkermansia muciniphila in hundreds of human stool-derived in vitro microbial communities, confirming that the data-driven approaches can predict the colonization outcomes in experiments. Furthermore, we find that while most resident species are predicted to have a weak negative impact on the colonization of exogenous species, strongly interacting species could significantly alter the colonization outcomes, e.g., Enterococcus faecalis inhibits the invasion of E. faecium invasion. The presented results suggest that the data-driven approaches are powerful tools to inform the ecology and management of microbial communities.https://cassyni-user-files-prod.s3.amazonaws.com/F2tFNYeGzUZXLfq6vpkE8n https://cassyni.com/slides/outline/LUgfKJPNgbDgjcQqxvKUBo https://cassyni.com/events/LUgfKJPNgbDgjcQqxvKUBo/abstract https://cassyni-user-files-prod.s3.amazonaws.com/6dqMUJ8U8LDp2nPGqSptyU https://cassyni.com/events/LUgfKJPNgbDgjcQqxvKUBo?videoPreview=1 Wastewater sequencing reveals community and variant dynamics of the collective human viromenohttps://cassyni.com/events/LUgfKJPNgbDgjcQqxvKUBo?videoPreview=12023-12-19T12:00:00+00:00688.0Microbiome Virtual International Forum Wastewater is a discarded human by-product, but its analysis may help us understand the health of populations. Epidemiologists first analyzed wastewater to track outbreaks of poliovirus decades ago, but so-called wastewater-based epidemiology was reinvigorated to monitor SARS-CoV-2 levels while bypassing the difficulties and pit falls of individual testing. Current approaches overlook the activity of most human viruses and preclude a deeper understanding of human virome community dynamics. Here, we conduct a comprehensive sequencing-based analysis of 363 longitudinal wastewater samples from ten distinct sites in two major cities. Critical to detection is the use of a viral probe capture set targeting thousands of viral species or variants. Over 450 distinct pathogenic viruses from 28 viral families are observed, most of which have never been detected in such samples. Sequencing reads of established pathogens and emerging viruses correlate to clinical data sets of SARS-CoV-2, influenza virus, and monkeypox viruses, outlining the public health utility of this approach. Viral communities are tightly organized by space and time. Finally, the most abundant human viruses yield sequence variant information consistent with regional spread and evolution. We reveal the viral landscape of human wastewater and its potential to improve our understanding of outbreaks, transmission, and its effects on overall population health. Link to OA paper: https://www.nature.com/articles/s41467-023-42064-1https://cassyni-user-files-prod.s3.amazonaws.com/6dqMUJ8U8LDp2nPGqSptyU https://cassyni.com/slides/outline/Ushw6vPJ9NdftwmK2meXQh https://cassyni.com/events/Ushw6vPJ9NdftwmK2meXQh/abstract https://cassyni-user-files-prod.s3.amazonaws.com/LDyKW269dPdVe31r8XpQGe https://cassyni.com/events/Ushw6vPJ9NdftwmK2meXQh?videoPreview=1 Do you see what I see? Improving color accessibility and organization of microbiome data visualizations with the microshades R packagenohttps://cassyni.com/events/Ushw6vPJ9NdftwmK2meXQh?videoPreview=12023-04-19T12:00:00+00:00496.04Microbiome Virtual International Forum Background: Color Vision Deficiency (CVD), commonly known as colorblindness, affects approximately 300 million people worldwide. Individuals with CVD do not experience complete loss of color vision, but have reduced ability to distinguish different colors. When creating scientific figures, it is important to consider that individuals with CVD may not perceive all colors as intended. While there are several CVD friendly color palettes available, they are often insufficient for visualizing complex data that is often generated in microbiome studies. Methods: To overcome CVD accessibility for microbiome datasets, we developed an R package, microshades. Microshades includes CVD accessible color palettes and data organization functions. To construct the palettes, hue (type of color), chroma (colorfulness), and luminance (brightness) were adjusted for optimal visual distinction and CVD accessibility. All shades were tested with a CVD simulator (cvdemulator) for accessibility. In addition to accessible color palettes, we also provide data organization functions. These include grouping data by taxonomic ranking, sorting the data vertically and horizontally, and restructuring the plot legends. Results: Each microshades color palette contains six hues with five sequential variations of chroma and luminance per hue, for a total of 30 available colors per palette. The microshades_cvd_palettes colors are universally CVD accessible to individuals with the three most common types of CVD (Deuteranope, Protanope, and Tritanope). The individual hues of the microshades_palettes colors are CVD friendly, but when used in conjunction with multiple hues, may not be universally accessible to all forms of CVD. Discussion: The microshades R package is a visualization tool designed for microbiome researchers. The package contains two CVD accessible palettes, along with several organization features. The microshades package can be used in conjunction with common microbiome R packages, such as phyloseq, to enhance microbiome data visualization. Link to paper: https://journals.asm.org/doi/10.1128/mra.00795-22https://cassyni-user-files-prod.s3.amazonaws.com/LDyKW269dPdVe31r8XpQGe https://cassyni.com/slides/outline/XLwxLLcvLfQAFtEsaTZA8d https://cassyni.com/events/XLwxLLcvLfQAFtEsaTZA8d/abstract https://cassyni-user-files-prod.s3.amazonaws.com/XGis3ZSg8GqxCpRjsJZUmC https://cassyni.com/events/XLwxLLcvLfQAFtEsaTZA8d?videoPreview=1 Turbulent boundary layers over acoustic liners: an aerodynamic and aeroacoustic perspectivenohttps://cassyni.com/events/XLwxLLcvLfQAFtEsaTZA8d?videoPreview=12024-02-21T11:00:00+00:002680.48Department of Aeronautics and AstronauticsThis talk ill explore the flow physics of compressible turbulent flows over perforated plates, typical of acoustic liners used in modern jet engines. We will examine the aerodynamic drag induced by acoustic liners and compare it with rough surfaces. Utilizing a comprehensive direct numerical simulation (DNS) dataset, which encompasses turbulent channel flow across various acoustic liner geometries and Reynolds numbers, we demonstrate that acoustic liners function as porous surfaces and operate in the fully rough regime under normal conditions. With this enhanced understanding of the flow physics, we develop optimized facesheet geometries that reduce drag while maintaining the acoustic performance of the baseline design. Lastly, we will present current simulations of turbulent boundary layers over acoustic liners, both with and without incoming sound waves, focusing on the internal boundary layer these surfaces induce and the resulting nonequilibrium effects.https://cassyni-user-files-prod.s3.amazonaws.com/XGis3ZSg8GqxCpRjsJZUmC https://cassyni.com/slides/outline/6eXk2AGgPmiD6Rx94Ey4Sy https://cassyni.com/events/6eXk2AGgPmiD6Rx94Ey4Sy/abstract https://cassyni-user-files-prod.s3.amazonaws.com/2p4YVdfYHhks5BAV1L5JNi https://cassyni.com/events/6eXk2AGgPmiD6Rx94Ey4Sy?videoPreview=1 Quantum Transport Theory of Strongly Correlated Matternohttps://cassyni.com/events/6eXk2AGgPmiD6Rx94Ey4Sy?videoPreview=12024-09-26T12:00:00+00:002126.24Physics ReportsKubo formulas for electric and thermal magneto-conductivities are generally notoriously costly to compute in strong scattering regime where Boltzmann equation and Hall conductivity proxies exceed their validity. This seminar cover three recently developed approaches which can significantly simplify such calculations. 1. Degeneracy-projected polarization (DPP) formulas for Hall-type conductivities, which reduce the Kubo formulas to on-shell expressions with significantly less matrix elements. The DPP formulas reduce to Berry curvature integral formulas for perfectly periodic models. 2. Continued fraction (CF) representation of dynamical longitudinal conductivities. The calculations produce a set of thermodynamic averages, which can be controllably extrapolated using their mathematical relations to low and high frequency conductivity asymptotics. 3. Hall-type coefficients summation formulas, which are constructed from thermodynamic expectation values of static operators. The thermodynamic formulas (2 and 3) are derived in the operator Hilbert space formalism, which avoids the opacity and high computational cost of the Hamiltonian eigenspectrum. The coefficients can be computed d by well established imaginary-time Monte Carlo sampling, high temperature expansion, traces of operator products, and variational wavefunctions at low temperatures. The power of approaches 1--3 is demonstrated by their application to strongly interacting n models of lattice electrons and bosons. The calculations clarify the far-reaching influence of strong many-body interactions on metallic transport near Mott insulators. Future directions for these approaches are discussed. https://cassyni-user-files-prod.s3.amazonaws.com/2p4YVdfYHhks5BAV1L5JNi https://cassyni.com/slides/outline/VN5K1JsxZDvW7A6QgdSde5 https://cassyni.com/events/VN5K1JsxZDvW7A6QgdSde5/abstract https://cassyni-user-files-prod.s3.amazonaws.com/HfzkCk1jQx2ZSLdDzbnr5C https://cassyni.com/events/VN5K1JsxZDvW7A6QgdSde5?videoPreview=1 Qualitative and Quantitative Features of Delay Differential Equations with Biological Systemsnohttps://cassyni.com/events/VN5K1JsxZDvW7A6QgdSde5?videoPreview=12025-06-24T14:00:00+00:001229.88NODYSThis paper proposes a delay differential model for glucose-insulin endocrine and metabolic regulation, incorporating beta-cell dynamics to maintain bloodstream insulin concentration. Two-time delays are involved in the model, which represent delayed insulin secretion and glucose reduction. Moderate hyperglycemia causes beta-cell growth (negative feedback), while severe hyperglycemia causes beta-cell reduction (positive feedback). A Hopf-bifurcation occurs when a time delay passes a bifurcation point. Based on biological findings, the model exhibits periodic oscillations. Numerical simulations have validated the theoretical results.https://cassyni-user-files-prod.s3.amazonaws.com/HfzkCk1jQx2ZSLdDzbnr5C https://cassyni.com/slides/outline/RuY5gXMHV23s5Tnr2y4g7F https://cassyni.com/events/RuY5gXMHV23s5Tnr2y4g7F/abstract https://cassyni-user-files-prod.s3.amazonaws.com/DiqXwuMRJeXsckTUGe4ju8 https://cassyni.com/events/RuY5gXMHV23s5Tnr2y4g7F?videoPreview=1 A Set-valued Impact Law Approach for Modeling and Analysis of Rigid Contact Universal Joint with Clearancenohttps://cassyni.com/events/RuY5gXMHV23s5Tnr2y4g7F?videoPreview=12025-06-24T10:00:00+00:00711.44NODYSThis study models and analyzes the dynamic behavior of a universal joint with mechanical clearance, emphasizing the impulsive impact dynamics at the cross-piece and yoke rigid interface using a set-valued impact law approach. This research sheds light on complex contact interactions of U-Joints which were previously not addressed.https://cassyni-user-files-prod.s3.amazonaws.com/DiqXwuMRJeXsckTUGe4ju8 https://cassyni.com/slides/outline/UNn6uwaugJpMSQGQaeyJqB https://cassyni.com/events/UNn6uwaugJpMSQGQaeyJqB/abstract https://cassyni-user-files-prod.s3.amazonaws.com/ELeYFkuprUE3PCqapfS8Mt https://cassyni.com/events/UNn6uwaugJpMSQGQaeyJqB?videoPreview=1 Simulation of the Piezoelectric Hysteresis Effects in Ultrasonic Motors Using Models with Masing–Bouc-Wen's Structurenohttps://cassyni.com/events/UNn6uwaugJpMSQGQaeyJqB?videoPreview=12025-06-24T11:00:00+00:00754.84NODYSThis study investigates the impact of piezoelectric hysteresis on the performance characteristics of ultrasonic motors (USMs). The hysteretic energy dissipation is simulated using models incorporating a Masing–Bouc-Wen structure with additional state variables. Contour plots of rotor speed, startup response time, and relative efficiency are obtained as functions of the hysteretic dissipation parameters. https://cassyni-user-files-prod.s3.amazonaws.com/ELeYFkuprUE3PCqapfS8Mt https://cassyni.com/slides/outline/5AJhjpBF3nnbwULZkr9LDj https://cassyni.com/events/5AJhjpBF3nnbwULZkr9LDj/abstract https://cassyni-user-files-prod.s3.amazonaws.com/AGJJd7pkESfEb49ucygnNJ https://cassyni.com/events/5AJhjpBF3nnbwULZkr9LDj?videoPreview=1 Research on predefined-time control of attitude pointing for parallel mechanismnohttps://cassyni.com/events/5AJhjpBF3nnbwULZkr9LDj?videoPreview=12025-06-24T11:00:00+00:00702.68NODYSA predefined-time attitude pointing control strategy based on a parallel platform is proposed to address the rapid, high-precision, and stable attitude pointing control of satellites within a limited timeframe. The approach involves analyzing the kinematics of the six-degree-of-freedom parallel platform's legs using the Newton-Euler method, establishing dynamic equations through force analysis of the legs and payload platform, and calculating dynamic response characteristics. Coordinate transformations and attitude descriptions based on Cardan angles are employed to derive the kinematic and dynamic equations of the platform's attitude motion. To enhance the speed and determinism of attitude pointing, a predefined-time stability theory forms the basis for designing a cascade control strategy and a robust sliding mode controller for attitude stability.https://cassyni-user-files-prod.s3.amazonaws.com/AGJJd7pkESfEb49ucygnNJ https://cassyni.com/slides/outline/H1tpxrDiz91R3BKDuwi5Qq https://cassyni.com/events/H1tpxrDiz91R3BKDuwi5Qq/abstract https://cassyni-user-files-prod.s3.amazonaws.com/BzZvHWb5mYbaSWgoQMpdGr https://cassyni.com/events/H1tpxrDiz91R3BKDuwi5Qq?videoPreview=1 Comparison of a Ramping and Steady State Excitation on the Bifurcation Structure of a Multi-bubble Systemnohttps://cassyni.com/events/H1tpxrDiz91R3BKDuwi5Qq?videoPreview=12025-07-09T16:00:00+00:00746.08NODYSThe combination of experiment and numerical investigation has unlocked new understanding of the mechanisms that mediate the reverse bifurcation first described by Lauterborn and Cramer in 1981.https://cassyni-user-files-prod.s3.amazonaws.com/BzZvHWb5mYbaSWgoQMpdGr https://cassyni.com/slides/outline/D4hzbP3XUUaGFWrYWq82ow https://cassyni.com/events/D4hzbP3XUUaGFWrYWq82ow/abstract https://cassyni-user-files-prod.s3.amazonaws.com/XMUSJPKxAkWBrPttcq4WqL https://cassyni.com/events/D4hzbP3XUUaGFWrYWq82ow?videoPreview=1 ITG-turbulence-driven Alfvénic modes in the Wendelstein 7-X stellaratornohttps://cassyni.com/events/D4hzbP3XUUaGFWrYWq82ow?videoPreview=12025-05-29T15:00:00+00:003130.12Journal of Plasma PhysicsThroughout several operational phases (2018–2025) of Wendelstein 7-X (W7-X), an optimized stellarator in Greifswald, Germany, magnetic and density fluctuation measurements show that shear Alfvén wave (SAW) excitation correlates with the broadband turbulence spectrum. The typical role of SAWs in magnetic confinement fusion (MCF) research relates to their excitation by energetic particles. In recent years, the interaction between SAWs and turbulence has revealed important numerical results in the presence of energetic particles. In W7-X, despite the absence of conventional energetic particle sources, SAWs persist in most experiments. The measured Alfvénic fluctuations resemble observations in ohmic tokamak scenarios, such as those at TFTR, ASDEX Upgrade, and TCV. Across various machines, common characteristics are evident for Alfvénic fluctuations correlated with the turbulence spectrum, in contrast to those driven by energetic particles. Alfvén eigenmodes (AEs) detected through Mirnov coil measurements are consistent with ellipticity, toroidicity, and non-circularity induced AEs. Phase Contrast Imaging (PCI) measurements indicate dominant ion-temperature-gradient (ITG) driven turbulence in these plasmas. We observe a correlation between the amplitudes of AEs and density fluctuations across different magnetic field configurations. Nonlinear gyrokinetic simulations using the EUTERPE code show that ITG turbulence can simultaneously drive zonal flows and generate AEs.https://cassyni-user-files-prod.s3.amazonaws.com/XMUSJPKxAkWBrPttcq4WqL https://cassyni.com/events/FXx1poH9fmLkcTL74X2fXs/abstract https://cassyni-user-files-prod.s3.amazonaws.com/SAfbKD2wZShCyF4SBnYiPx https://cassyni.com/slides/outline/C5QnW1kUbZU7am2YQrei13 https://cassyni.com/events/C5QnW1kUbZU7am2YQrei13/abstract https://cassyni-user-files-prod.s3.amazonaws.com/LyrkL2jvx8smKtbkbj7d9p https://cassyni.com/events/C5QnW1kUbZU7am2YQrei13?videoPreview=1 Deployable fusion plasmas?nohttps://cassyni.com/events/C5QnW1kUbZU7am2YQrei13?videoPreview=12024-10-24T15:00:00+00:002949.32Journal of Plasma PhysicsThe enormous and urgent challenges to provide the world with sufficient and suitable low carbon energy has given new impetus to fusion research. Some very substantial programmes aimed at pilot or developmental fusion power plants are now underway, usually at a very rapid pace. This pace can challenge the traditional scientific method (decisions based on empirical evidence supported by scientific understanding), so these programmes accept significant or even large uncertainties in the plasma and other systems. However, it seems likely that the uncertainty appetite will be reduced for deployable fusion plants, e.g. those built and operated for energy utilities perhaps part of national energy policies. The pace may still be high with such plants potentially designed in parallel with the pilot plants yet with significant differences. It is worth considering the impact on plasma R&D by asking a few questions about how one might arrive at a plasma which has the desired performance and can be adopted and integrated with sufficient confidence into a deployable plant. Some transitions in thinking and approach may be needed on the way..https://cassyni-user-files-prod.s3.amazonaws.com/LyrkL2jvx8smKtbkbj7d9p https://cassyni.com/slides/outline/NT46azrPDY2GFk25iXY3KB https://cassyni.com/events/NT46azrPDY2GFk25iXY3KB/abstract https://cassyni-user-files-prod.s3.amazonaws.com/S5V6tZqBgR2D41xuBqqWdc https://cassyni.com/events/NT46azrPDY2GFk25iXY3KB?videoPreview=1 Radiative cooling-driven (thermal) instabilities in weakly magnetized, diffuse, hot plasmasnohttps://cassyni.com/events/NT46azrPDY2GFk25iXY3KB?videoPreview=12023-07-13T15:00:00+00:004339.12Journal of Plasma PhysicsAstrophysical environments are diverse in characteristic density, temperature, and magnetic field. For example, intracluster and circumgalactic medium (ICM/CGM) are large-scale, mildly magnetized, weakly collisional, hot, and diffuse environments. On the other hand, solar and planetary coronae have strong magnetic fields in hot and relatively tighter gravitationally bound atmospheres. A common feature in many of these distinctly different environments is the multiphase nature of the medium, or in other words, the local coexistence of a range of temperatures and the lack of monolithic cold or hot phase. This feature suggests (i) maintenance of an approximate thermal equilibrium in a time-averaged sense and (ii) a mechanism to produce multiphase condensation despite an equilibrium. In this talk, I will discuss the physical mechanisms responsible for (i) and (ii) in the ICM/CGM using analytic models and numerical experiments. I will include a discussion on the permitted length scales in a multiphase medium. Further, I will highlight the role of the weak magnetic field in condensation (specifically, large-scale mode along the field) and maintenance of the hot background medium (energy transport problem). Some of these ideas can also be relevant to speculate on such instabilities and interpret solar prominence, clumpy AGN winds, and condensation in planetary coronae.https://cassyni-user-files-prod.s3.amazonaws.com/S5V6tZqBgR2D41xuBqqWdc https://cassyni.com/slides/outline/NwhhdgVuezaKFWYyJxpqaV https://cassyni.com/events/NwhhdgVuezaKFWYyJxpqaV/abstract https://cassyni-user-files-prod.s3.amazonaws.com/PwkNc8d5atCQ338ea46Whc https://cassyni.com/events/NwhhdgVuezaKFWYyJxpqaV?videoPreview=1 Fully kinetic simulations of plasma accretion in a three-dimensional shearing boxnohttps://cassyni.com/events/NwhhdgVuezaKFWYyJxpqaV?videoPreview=12022-12-01T16:00:00+00:003274.44Journal of Plasma PhysicsOne of the main uncertainties in the physics of plasma accretion onto compact objects (black holes and neutron stars) is represented by the dynamics of microscopic processes at kinetic scales. Although often expected to be collisionless, accretion flows around black holes are customarily studied with magnetohydrodynamic (MHD) models; these models however do not include out-of-equilibrium physics and cannot describe nonthermal particle acceleration and radiation, particle scattering and diffusion, and the transport of angular momentum through astrophysical accretion disks. To study these processes self-consistently, fully kinetic simulations are necessary; but the prohibitive costs typically associated to such numerical experiments have so far inhibited significant progress in this direction. In this talk, we will present the first mesoscale (i.e. attaining global MHD-like behavior) simulations of plasma accretion carried out with a fully kinetic approach in three dimensions. Our work is based on the shearing-box paradigm, which allows the first-principles study of a localized sector of an accretion disk at affordable costs. Our 3D kinetic simulations are large enough to reach convergence (with respect to physical parameters and box size), allowing us to analyze the detail of particle acceleration and angular-momentum transport in the turbulent plasma dynamics developing in a typical collisionless accretion flow.https://cassyni-user-files-prod.s3.amazonaws.com/PwkNc8d5atCQ338ea46Whc https://cassyni.com/slides/outline/HWa48AP8pxVEreJji3q3b3 https://cassyni.com/events/HWa48AP8pxVEreJji3q3b3/abstract https://cassyni-user-files-prod.s3.amazonaws.com/JWcj6cWJkr7KeAtQy96iiA https://cassyni.com/events/HWa48AP8pxVEreJji3q3b3?videoPreview=1 Collisionless Shockwaves in Magnetized High-Energy-Density Laboratory Plasmasnohttps://cassyni.com/events/HWa48AP8pxVEreJji3q3b3?videoPreview=12022-06-30T15:00:00+00:003063.32Journal of Plasma PhysicsAs a fundamental process for converting kinetic to thermal energy, collisionless shocks are ubiquitous throughout the heliosphere and astrophysical systems, from Earth's magnetosphere to supernova remnants. While these shocks have been studied for decades by spacecraft, telescopes, and numerical simulations, there remain key open questions in the fundamental physics of collisionless shocks, such as: How do shocks accelerate particles to extremely high energies? or How is energy partitioned between particles across a shock? In this talk, I will discuss results from high-energy-density experiments and simulations on the formation of supercritical collisionless shocks created through the interaction of a supersonic laser-driven magnetic piston and magnetized ambient plasma. Through proton and refractive imaging, we observe for the first time a magnetized collisionless shock, comparable to some of the strongest shocks in the heliosphere. By probing particle velocity distributions with Thomson scattering, we directly measure the coupling interactions between the piston and ambient plasmas that are critical steps in the formation of magnetized collisionless shocks. Particle-in-cell simulations constrained by experimental data further detail the shock formation process and predict key signatures that are observed in experiments. I will also discuss how the development of this experimental platform can complement, and in some cases overcome, the limitations of similar measurements undertaken by spacecraft missions and can allow novel investigations of energy partitioning and particle acceleration in shocks.https://cassyni-user-files-prod.s3.amazonaws.com/JWcj6cWJkr7KeAtQy96iiA https://cassyni.com/events/VrnAHFZFoQL6kKYYgQPmjB/abstract https://cassyni-user-files-prod.s3.amazonaws.com/D5BELAinVqqaMkxkV8r1N6 https://cassyni.com/events/YL2BWfnszh6b7G27E6JQT7/abstract https://cassyni-user-files-prod.s3.amazonaws.com/FAw3n5DmN3BzTxTyefsFBL https://cassyni.com/slides/outline/QvJ7pR61Qpo5MDqCfvgn13 https://cassyni.com/events/QvJ7pR61Qpo5MDqCfvgn13/abstract https://cassyni-user-files-prod.s3.amazonaws.com/7Pj1uFT1Mcp5hB2hu7YjeW https://cassyni.com/events/QvJ7pR61Qpo5MDqCfvgn13?videoPreview=1 Electron holes in collisionless plasmas: how long do these common nonlinear structures last?nohttps://cassyni.com/events/QvJ7pR61Qpo5MDqCfvgn13?videoPreview=12022-03-10T16:00:00+00:002959.04Journal of Plasma PhysicsElectron phase-space holes are now widely observed in space plasmas. They consist of a solitary positive potential peak with depleted electron population on trapped orbits that sustains the potential; and so they are intrinsically kinetic: governed by the Vlasov equation. Important new details about their speed and structure are now emerging from multi-satellite measurements. This talk will introduce the principles, observations, and simulations of electron holes; explain the ways that they behave like composite objects possessing lumped momentum, negative mass, and kinematic properties; and show how these concepts determine how and when they break up by instabilities. Instability probably determines the lifetime of a hole when collisions are negligible.https://cassyni-user-files-prod.s3.amazonaws.com/7Pj1uFT1Mcp5hB2hu7YjeW https://cassyni.com/events/TPY93qKdc7ZZiAJmDcbQiy/abstract https://cassyni-user-files-prod.s3.amazonaws.com/NJ9woCyUzCpd7wowVQmYTG https://cassyni.com/events/88FaFB6AVFxgwaGGJK172m/abstract https://cassyni.com/slides/outline/CZ2MKQLD8fkKoxTtcWqZbT https://cassyni.com/events/CZ2MKQLD8fkKoxTtcWqZbT/abstract https://cassyni-user-files-prod.s3.amazonaws.com/4haRq8ZsW8MbaBb66RhRzv https://cassyni.com/events/CZ2MKQLD8fkKoxTtcWqZbT?videoPreview=1 Long-Term Outcomes of Transarterial Embolization for Pulmonary Arteriovenous Malformations in Pediatric Hereditary Hemorrhagic Telangiectasianohttps://cassyni.com/events/CZ2MKQLD8fkKoxTtcWqZbT?videoPreview=12025-10-14T09:49:51+00:00692.32Society for Pediatric Interventional Radiology## Introduction Pulmonary arteriovenous malformations (PAVMs) are a common manifestation of hereditary hemorrhagic telangiectasia (HHT), and may lead to significant morbidity in children. Transarterial embolization (TAE) is the standard treatment, but pediatric-specific long-term data remain limited. This study aimed to assess long-term clinical and imaging outcomes of TAE in pediatric HHT and to identify predictors of oxygenation response and lesion durability. ## Materials and Methods This retrospective cohort included 33 pediatric HHT patients (mean age: 8.3 years) who underwent TAE for 63 PAVMs between 2004 and 2024. Clinical outcome was assessed by peripheral oxygen saturation (SpO₂) at baseline and at 1 month, 1, 3, and 5 years. Lesion-level outcomes included persistence, reperfusion, and recanalization. Regression models were used to identify clinical and anatomical predictors. Technical success, embolic material, number and size of feeding and draining vessels, and adverse events (AEs) were recorded. AEs were classified using the CIRSE system. ## Results TAE had a technical success rate of 96.8%. Median SpO₂ improved from 95% at baseline to 98% at 1 month (p<0.001), and remained at 98% at 1 (p<0.001) and 3 years (p=0.002), and 97% at 5 years (p=0.03). Diffuse disease and HHT type 1 were associated with lower follow-up SpO₂ (p=0.024–0.033 and p=0.023). Lesion persistence, reperfusion, and recanalization occurred in 16%, 19%, and 6%, respectively. Persistence was associated with larger size (p=0.007), diffuse disease (p=0.008), and number of draining veins (p=0.009). Reperfusion was associated with lesion complexity (p=0.015) and number of feeding arteries (p=0.030); recanalization with number of feeding arteries (p=0.046). AE rate was 12%, mostly minor. ## Discussion TAE proved to be effective and safe for managing PAVMs in pediatric patients with HHT, with sustained oxygenation improvement and low complication rates. Most lesions remained occluded over time, and SpO₂ levels improved significantly at early follow-up and remained stable for up to 5 years. Importantly, our study identified diffuse PAVM disease and HHT type 1 as consistent predictors of lower oxygenation at follow-up, even after adjustment for baseline SpO₂. This supports prior observations that diffuse involvement may represent a distinct clinical phenotype associated with worse prognosis. Additionally, we found that lesion size, vascular complexity, and number of draining veins were significantly associated with persistence, while reperfusion and recanalization were linked to lesion complexity and feeding artery count. These findings suggest that anatomical characteristics influence embolization durability and should be considered when planning treatment and surveillance strategies. Although embolization alone may not prevent long-term complications in diffuse cases, early intervention may still offer clinical benefits, particularly in maintaining oxygenation and delaying progression. Our data reinforce the need for tailored follow-up in patients with unfavorable features, and suggest that adjunctive or staged strategies, including surgery, may be required in select cases. Compared with previous pediatric series, our study provides a more granular assessment of outcomes by combining longitudinal SpO₂ analysis and lesion-level modeling, offering clinically relevant insight into which patients are most likely to benefit from treatment and which may require more intensive management.https://cassyni-user-files-prod.s3.amazonaws.com/4haRq8ZsW8MbaBb66RhRzv https://cassyni.com/events/UrAgpJ3YzXghpZNKafku6M/abstract https://cassyni-user-files-prod.s3.amazonaws.com/YSMsyVoTEYaCEHjLGfe4qC https://cassyni.com/slides/outline/C5idkwRE2Xf7CKGoWwauB3 https://cassyni.com/events/C5idkwRE2Xf7CKGoWwauB3/abstract https://cassyni-user-files-prod.s3.amazonaws.com/KCQwbDL6GAKBEG4D5aTPBc https://cassyni.com/events/C5idkwRE2Xf7CKGoWwauB3?videoPreview=1 How Current Research Practices Are Damaging Science And How Open Science Offers Some Solutionsnohttps://cassyni.com/events/C5idkwRE2Xf7CKGoWwauB3?videoPreview=12021-05-03T03:00:00+00:003296.96UKRNQuasi-cumulative science - where we think we are building on foundations of prior work, only to find the earlier work isn't solid - has a detrimental effect on science. There is no single cause for this, but rather an unfortunate combination of factors. Five of these, together with possible solutions, are discussed: 1. Publication bias - One solution is Registered Reports, which decouples decisions about publication from knowledge of research results. 2. Citation bias. Creates the impression of widespread agreement on a topic, because literature that does not support it gets forgotten - Systematic reviews are one method that attempts to redress the imbalance in citations, but it is not infallible. Unlikely to change unless we increase awareness of the serious consequences of citation bias, and train researchers to seek out and evaluate evidence contrary to their position. 3. P-hacking, or selective reporting of only positive findings from within a study, often after exploration of many different analysis options. I discuss one form of p-hacking which might be termed 'moving goalposts', where studies that appear to replicate an initial finding actually fail to do so, but instead present results on a related question - Registered reports offer a solution to p-hacking. 4. Low statistical power, often due to small sample sizes - Training scientists to explore simulated data is one way to counteract underpowered studies. 5. Obsession of funders/journals with novelty. A 'top down' influence that produces a distorted incentive structure for scientists, who avoid slow, careful science that builds up knowledge on a topic, and rather feel they must overhype results and jump from one hot topic to another - The solution is for funders and institutions to change how they evaluate researchers, to focus on rewarding those who adopt open, reproducible methods. The Hong Kong Principles for assessing researchers are introduced as one such approach.https://cassyni-user-files-prod.s3.amazonaws.com/KCQwbDL6GAKBEG4D5aTPBc https://cassyni.com/slides/outline/3Bf3KpZNVEikxsMA7Q9g1K https://cassyni.com/events/3Bf3KpZNVEikxsMA7Q9g1K/abstract https://cassyni-user-files-prod.s3.amazonaws.com/7UD3MKJUWDG2E1PXSojQSi https://cassyni.com/events/3Bf3KpZNVEikxsMA7Q9g1K?videoPreview=1 Upside-Down and Inside-Out: The Biomechanics of Cell Sheet Foldingnohttps://cassyni.com/events/3Bf3KpZNVEikxsMA7Q9g1K?videoPreview=12019-01-18T13:00:00+00:003005.44UK Fluids NetworkDeformations of cell sheets are ubiquitous in early animal development, often arising from a complex and poorly understood interplay of cell shape changes, division, and migration. I will describe our work on perhaps the simplest example of cell sheet folding: the “inversion” process of the algal genus Volvox, during which spherical embryos turn themselves inside out through a process hypothesized to arise from cell shape changes alone. We have used light sheet microscopy to obtain the first three-dimensional visualizations of inversion in vivo, and developed the first theory of this process, in which cell shape changes appear as local variations of intrinsic curvature, contraction and stretching of an elastic shell. Our results support a scenario in which these active processes function in a defined spatio-temporal manner to enable inversion.https://cassyni-user-files-prod.s3.amazonaws.com/7UD3MKJUWDG2E1PXSojQSi https://cassyni.com/slides/outline/8cNM7twrGruyqVKkP4MEaZ https://cassyni.com/events/8cNM7twrGruyqVKkP4MEaZ/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Dw9uQFV3EGMKnL9z2AvqEv https://cassyni.com/events/8cNM7twrGruyqVKkP4MEaZ?videoPreview=1 First lecture on micropolar chiral elasticitynohttps://cassyni.com/events/8cNM7twrGruyqVKkP4MEaZ?videoPreview=12022-11-29T14:00:00+00:002217.12MetaMATIn this lecture, I will introduce some basics of micropolar continuum elastic theory and its applications to the continuum modeling of chiral elastic metamaterials. Due to mirror symmetry breaking, chiral elastic metamaterials can exhibit interesting properties impossible within achiral ones, such as static push-to-twisting coupling and dynamic chiral phonons or acoustical activity. With the examples, one can see micropolar continuum theory can correctly describe the above behavior as well as related size effects. In traditional chiral metamaterials, mostly with cubic symmetry, chiral phonons and acoustical activity are allowed only along several phonon propagation directions. Chiral elastic metamaterials that support isotropic chiral phonons are preferred in practical applications. Here, chiral elastic metamaterials with isotropic properties are designed based on quasicrystalline lattice and periodic cubic lattice. Both designs are verified numerically by phonon band structure calculations. https://cassyni-user-files-prod.s3.amazonaws.com/Dw9uQFV3EGMKnL9z2AvqEv https://cassyni.com/events/LTxULvzLDD8nwCJQY9uymf/abstract https://cassyni-user-files-prod.s3.amazonaws.com/4r6dX116z5MUKT4n2xCEFQ https://cassyni.com/events/LTxULvzLDD8nwCJQY9uymf?videoPreview=1 Opening talknohttps://cassyni.com/events/LTxULvzLDD8nwCJQY9uymf?videoPreview=12022-05-06T16:00:00+00:00377.92Acta Scientiarum MathematicarumAbstract not yet added.https://cassyni-user-files-prod.s3.amazonaws.com/4r6dX116z5MUKT4n2xCEFQ https://cassyni.com/events/XLDmMyDssHKGTU8S9h9fiV/seminar/qa https://cassyni.com/events/XLDmMyDssHKGTU8S9h9fiV/abstract https://cassyni-user-files-prod.s3.amazonaws.com/GemykbJ16Uk5AZSrKoXxdk https://cassyni.com/slides/outline/TsgY3BhCo5SdRmpsW2miBf https://cassyni.com/events/TsgY3BhCo5SdRmpsW2miBf/abstract https://cassyni-user-files-prod.s3.amazonaws.com/67RdUSGnJCjoJWbBxgNgj8 https://cassyni.com/events/TsgY3BhCo5SdRmpsW2miBf?videoPreview=1 Controversial issues concerning the origin of the Earth’s magnetic fieldnohttps://cassyni.com/events/TsgY3BhCo5SdRmpsW2miBf?videoPreview=12020-04-13T13:00:00+00:002706.32UK Fluids NetworkThe origin of the Earth's magnetic field is an apparently simple, yet challenging problem. In terms of mathematical models, dynamo action in a rotating spherical domain is the -now well established- model to account for the magnetic field of planets and stars. Whereas the relevant equations are easily written, the parameters regime relevant to the Earth's core is so extreme that a numerical solution with these parameters is out of reach of today's largest computers. This raises the daunting question of the relevance of today's state-of-the-art numerical models to the mechanisms at work within our planet. Several issues, on which researchers often disagree, naturally follow: What can we learn by comparing models with observations? Can we test numerical models against theoretical results? Can the relevant forces balance in the Earth's core be approached in numerical models? Could the unresolved small scale and rapidly varying flow be important? In this talk, I will try to place the emphasis on open and controversial issues.https://cassyni-user-files-prod.s3.amazonaws.com/67RdUSGnJCjoJWbBxgNgj8 https://cassyni.com/events/HW9iQieqnYbLfnSZPNMkLu/seminar/qa https://cassyni.com/slides/outline/HW9iQieqnYbLfnSZPNMkLu https://cassyni.com/events/HW9iQieqnYbLfnSZPNMkLu/abstract https://cassyni-user-files-prod.s3.amazonaws.com/YGhMjU2RZSxVtX8EHHHcwx https://cassyni.com/events/HW9iQieqnYbLfnSZPNMkLu?videoPreview=1 Fast Pressure and Temperature Sensitive Paints for Understanding Complex High-Speed Flowsnohttps://cassyni.com/events/HW9iQieqnYbLfnSZPNMkLu?videoPreview=12023-09-26T14:00:00+00:003436.68Experiments in FluidsThis lecture presents the recent development on fast-responding pressure- and temperature-sensitive paints, which have evolved into powerful experimental tools for studying complex flow problems. Key advances have been made in paint development, measurement method and data processing, which extends the applications of fast PSP/TSP from regular wind-tunnel tests to more challenging conditions featuring hypervelocity, high temperature and optical occlusion. Full-field pressure and temperature measurements with high spatial and temporal resolution have been achieved on both stationary and moving models. This improves our understanding of fluid problems such as flow transition, shock wave-boundary layer interaction and jet impingement noise.https://cassyni-user-files-prod.s3.amazonaws.com/YGhMjU2RZSxVtX8EHHHcwx https://cassyni.com/events/2ghb2DF6coyiMr9rNiY1oB/seminar/qa https://cassyni.com/slides/outline/2ghb2DF6coyiMr9rNiY1oB https://cassyni.com/events/2ghb2DF6coyiMr9rNiY1oB/abstract https://cassyni-user-files-prod.s3.amazonaws.com/SkioRM9CfmjxnAUx9PQtUW https://cassyni.com/events/2ghb2DF6coyiMr9rNiY1oB?videoPreview=1 Autonomy and Future Mobility in Aerospacenohttps://cassyni.com/events/2ghb2DF6coyiMr9rNiY1oB?videoPreview=12024-02-06T16:00:00+00:003535.36AIAA JournalThis talk will track the unique evolution of an aircraft from its origin as a single-seat eVTOL (electric vertical takeoff and landing) intended for personal use to becoming the first-ever all-electric, autonomous eVTOL air-taxi put forward for certification by the FAA. Discover what autonomous flight means, the unique technologies necessary to make it all work, and the challenges that remain. This talk will unpack the technological advancements, infrastructure developments, and changes in societal perceptions that that are needed for this aircraft to really 'take off,' and will conclude with insights on what developments in autonomous aviation could mean for passengers, pilots, and the aviation industry writ large.https://cassyni-user-files-prod.s3.amazonaws.com/SkioRM9CfmjxnAUx9PQtUW https://cassyni.com/events/PRxb5Yw2TQAEt7gJnPUWWZ/seminar/qa https://cassyni.com/slides/outline/PRxb5Yw2TQAEt7gJnPUWWZ https://cassyni.com/events/PRxb5Yw2TQAEt7gJnPUWWZ/abstract https://cassyni-user-files-prod.s3.amazonaws.com/EToo4WFD6vxfJZwAidt7jk https://cassyni.com/events/PRxb5Yw2TQAEt7gJnPUWWZ?videoPreview=1 Bat activity correlated with migratory insect bioflows in the Pyreneesnohttps://cassyni.com/events/PRxb5Yw2TQAEt7gJnPUWWZ?videoPreview=12023-10-27T14:00:00+00:002666.24Royal Society PublishingHigh altitude mountain passes in the Pyrenees are known to be important migratory hotspots for autumn migrating insects originating from large swathes of northern Europe. In the Pyrenees, prior research has focused on diurnal migratory insects. In this study, we investigate the nocturnal component of the migratory assemblage and ask if this transient food source is also used by bat species. Three seasons of insect trapping revealed 66 species of four different orders, 90% of which were Noctuid moths, including the destructive pest Helicoverpa armigera, otherwise known as the cotton bollworm. Acoustic bat detectors revealed that high activity of Nyctalus spp. and Tadarida teniotis bats were closely synchronized with the arrival of the migratory moths, suggesting this food source is important for both resident and migratory bats to build or maintain energy reserves. Bats of the Nyctalus spp. are likely migrating through the study site using fly-and-forage strategies or stopping over in the area, while resident T. teniotis may be exploiting the abundant food source to build fat stores for hibernation. This study shows that nocturnal migratory insects are abundant in the Pyrenees during autumn and interact during migration, not only with their co-migrant bats but also with resident bat species. Image by Harald Süpfle, Wikimedia Commons.https://cassyni-user-files-prod.s3.amazonaws.com/EToo4WFD6vxfJZwAidt7jk https://cassyni.com/slides/outline/DZGjJB9PhrMBVNeJ8W6Zgq https://cassyni.com/events/DZGjJB9PhrMBVNeJ8W6Zgq/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Hid2yf4UirG7Jr4Y9JWcpv https://cassyni.com/events/DZGjJB9PhrMBVNeJ8W6Zgq?videoPreview=1 Modeling, analysis and simulation: methane hydrate in the subsurfacenohttps://cassyni.com/events/DZGjJB9PhrMBVNeJ8W6Zgq?videoPreview=12022-12-06T17:00:00+00:003096.04Journal of Engineering Mathematics"If you never heard of methane hydrate, this might be good news". Methane hydrate is an ice-like crystalline substance made of water molecules encasing a molecule of methane, abundantly present in marine and Arctic sediments whenever pressure is high enough and temperature is low enough. Its presence is a “smoking gun” in climate science due to a possibility of release of methane gas into the atmosphere. On human time scales, methane hydrate is also an environmental hazard as well as a potential energy resource. In our work we considered a comprehensive PDE model for hydrate evolution which is a complex coupled system of 4 nonlinear equations coupled by thermodynamics constraints. To make progress towards the understanding of its mathematical structure, we must simplify the model, but the simplifications must be modest enough to keep the model relevant, mathematics interesting enough, and to allow for simulation of realistic case scenarios. In the talk we will present results of this compromise, and discuss the well-posedness of the model as well as numerical stability of finite volume schemes. https://cassyni-user-files-prod.s3.amazonaws.com/Hid2yf4UirG7Jr4Y9JWcpv https://cassyni.com/events/PRpUWQMbSbXc9RcTPiAy8H/abstract https://cassyni-user-files-prod.s3.amazonaws.com/PvtmW7w5Ar27YAmWvbe1LA https://cassyni.com/events/PRpUWQMbSbXc9RcTPiAy8H?videoPreview=1 Sharing research via the medianohttps://cassyni.com/events/PRpUWQMbSbXc9RcTPiAy8H?videoPreview=12022-10-25T01:00:00+00:004641.76Faculty of Business and EconomicsEngaging with the media is an excellent way to increase the reach of your research, extend your network and achieve impact. Join us for our session on “Sharing research via the media” and hear from media experts and academics on how to effectively translate your research for the media. Speakers: * Liam Dann, Business Editor at Large for the NZ Herald * Bodo Lang, Associate Professor in the Department of Marketing and Assistant Dean External Engagement * Michael Lee, Associate Professor in the Department of Marketing and Assistant Dean Prof Programs and Director of the MBA * Robert MacCulloch, Professor in the Department of Economics and holds the Matthew S. Abel Chair of Macroeconomics * Hamish McNicol, Co-Editor of NBR, National Business Review * Alex Sims, Associate Professor in the Department of Commercial Law and Associate at the UCL Centre for Blockchain Technologies Agenda * 2.00 pm: Welcome from the Dean of Business, Professor Susan Watson * 2.05 pm: Sophie Boladeras, Media Advisor to the Business School: What support for media engagement is available to researchers * 2.10 pm: The media panelists share how to effectively contribute to media * 2.25 pm: Academic panelists share the benefits of media engagement and strategies they have used for effective engagement. * 2.50 pm: Q&As * 3.15 to 4 pm: Networking over refreshments - Please RSVP for catering purposes. Organisers: The FRC taskforce 'Translation and External Impact': Antje Fiedler, Robert MacCulloch, Edward Yiu, Christiane Rupp, and Sophie Boladeras. For further information, please email Christiane Rupp @ c.rupp@auckland.ac.nz https://cassyni-user-files-prod.s3.amazonaws.com/PvtmW7w5Ar27YAmWvbe1LA https://cassyni.com/slides/outline/E4FoiQyYye23b1Uc27pnry https://cassyni.com/events/E4FoiQyYye23b1Uc27pnry/abstract https://cassyni-user-files-prod.s3.amazonaws.com/WVuwPMZ5gQzkpdW28gc5EN https://cassyni.com/events/E4FoiQyYye23b1Uc27pnry?videoPreview=1 Mapping Tumor-Infiltrating Microbes: Microniches to Single Cells in the Tumor Microenvironmentnohttps://cassyni.com/events/E4FoiQyYye23b1Uc27pnry?videoPreview=12024-10-08T01:00:00+00:002346.0Microbiome Virtual International ForumWithin human gastrointestinal tract tumors, malignant cells are surrounded by a complex ecosystem that includes a range of non-transformed human cells, as well as a diverse collection of microorganisms. The goal of my research program is to understand the impact of tumor-infiltrating bacteria on cancer progression and patient response to treatment. My talk will begin by discussing our findings that specific tumor-infiltrating bacteria are an intrinsic component of the colorectal cancer tumor microenvironment, persisting with the cancer even at distant metastatic sites (Bullman et al., Science, 2017). Additionally, I will highlight our serendipitous findings during the search for a small molecule inhibitor of the oncomicrobe Fusobacterium nucleatum (sensu lato), which revealed a complex interplay between the intratumoral microbiota and cancer treatment drugs (LaCourse et al., Cell Reports, 2022). I will also present our recent efforts to understand the contribution of the intratumoral microbiota to the tumor microenvironment (Galeano Nino et al., Nature, 2022). Specifically, we sought to determine where these microbes physically reside within tumor tissue, what host cells they are interacting with, and most importantly, the consequences of these interactions. To do this, we adapted and applied emerging technologies, including spatial transcriptomics, spatial proteomics, and single-cell sequencing (developed as INVADEseq, Galeano Nino et al., Nature Protocols, 2023), to profile host-microbial interactions in human oral and colorectal cancers. Our results reveal that the intratumoral microbiota is not randomly distributed within human oral and colorectal tumors but instead are localized to distinct microniches associated with immune and epithelial cell functions that support cancer progression. Finally, I will discuss our recent pangenomic and functional studies on Fusobacterium strains isolated from human colorectal cancer tumors, revealing a distinct Fusobacterium nucleatum (sensu lato) clade that dominates the human colorectal cancer tumor niche (Zepeda-Rivera et al., Nature, 2024). Understanding how the microbiota impacts cancer progression and patient responses to treatment will facilitate the development of novel therapeutic approaches that incorporate the microbial component of the tumor microenvironment. https://cassyni-user-files-prod.s3.amazonaws.com/WVuwPMZ5gQzkpdW28gc5EN https://cassyni.com/events/JzmUHsxgmaV5CD3XmcRw8Z/seminar/qa https://cassyni.com/slides/outline/JzmUHsxgmaV5CD3XmcRw8Z https://cassyni.com/events/JzmUHsxgmaV5CD3XmcRw8Z/abstract https://cassyni-user-files-prod.s3.amazonaws.com/XjXx14ftn4P116joQXZPbL https://cassyni.com/events/JzmUHsxgmaV5CD3XmcRw8Z?videoPreview=1 Segregation and armoring in bidisperse granular beds sheared by viscous liquidsnohttps://cassyni.com/events/JzmUHsxgmaV5CD3XmcRw8Z?videoPreview=12024-10-15T11:00:00+00:003812.64Granular MatterA granular bed sheared by a viscous flow undergoes a complex motion, with fluid-like (considerable rate of deformation) and solid-like (slowly deforming) regions, known as bedload and creep, respectively. This is commonly found in river beds, for instance, where, in addition, the bed consists of polydisperse grains. In such cases, the bed structure changes considerably along time, with bed hardening and grain segregation taking place simultaneously. As a consequence, the transport rate of grains decreases as time goes on. In this talk, I will show our findings on the short- and long-time responses of a bidisperse bed sheared by a viscous liquid. For that, we carried out experiments in an annular flume filled with grains and oil, and we made use of RIM (refractive index matching) visualizations (Gonzalez et al., Phys. Fluids, 2023). On the top of the flume, a rotating lid imposed a Couette-type oil flow that entrained grains of the granular bed. We show that most of segregation occurs during the very first stages of the flow, that bed hardening becomes stronger while bedload and creep weaken along time, and that creep and hardening continue over long time scales (140 h, in our experiments). We found the segregation rates, their variation with the applied shearing and time, the time evolution of creeping and bedload, and we propose characteristic times for both the segregation (upward motion of large particles) and bed hardening. In addition, we carried out CFD-DEM (computational fluid mechanics – discrete element method) simulations, and show that the direct action of fluid forces is significant for the upward motion of large grains in the middle and upper parts of the bedload layer, while only contact forces are significant in the creep layer and lower part of the bedload layer (Gonzalez and Franklin, Phys. Fluids, under review). Our results shed light on the time evolution of polydisperse granular beds under the action of fluid flows, such as happens in river beds.https://cassyni-user-files-prod.s3.amazonaws.com/XjXx14ftn4P116joQXZPbL https://cassyni.com/events/5AcYzjqzUkybZ2aprw5XPj/seminar/qa https://cassyni.com/slides/outline/5AcYzjqzUkybZ2aprw5XPj https://cassyni.com/events/5AcYzjqzUkybZ2aprw5XPj/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Vsu3Pyqv3FAyt33JxBeAZL https://cassyni.com/events/5AcYzjqzUkybZ2aprw5XPj?videoPreview=1 How small a nanoplastic can be? A discussion on the size of this ubiquitous pollutantnohttps://cassyni.com/events/5AcYzjqzUkybZ2aprw5XPj?videoPreview=12025-02-20T14:30:00+00:001578.04Cambridge PrismsMicroplastics pollution is a widely recognized issue, although significant analytical challenges remain to be overcome in order to achieve a more comprehensive ecological understanding. The complex nature of this pollutant, with its variable physical and chemical properties, presents considerable challenges when it comes to establishing standardized methods for studying it. One crucial factor that influences its toxicity is particle size, yet even this parameter lacks a well-established framework, especially in the case of nanoplastics. Although the size range limits are already proposed in the literature, where the most acceptable values for microplastics are from 1 to 5,000 μm and for nanoplastics are from 1 to 1,000 nm, we propose narrowing these limits to 0.1–1,000 μm and 10–100 nm, respectively. We based our discussion on conceptual terminology, polymer structure and toxicity, highlighting the significance of accurately defining their size range. The standardization of these limits will allow the development of more efficient approaches to studying this pollutant, enabling a comprehensive understanding of its ecological consequences and potential risks.https://cassyni-user-files-prod.s3.amazonaws.com/Vsu3Pyqv3FAyt33JxBeAZL https://cassyni.com/slides/outline/MxgigcMiogjS3qGq2WMGJy https://cassyni.com/events/MxgigcMiogjS3qGq2WMGJy/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Gnj6PbM5uodjtDVzmdBbUi https://cassyni.com/events/MxgigcMiogjS3qGq2WMGJy?videoPreview=1 Innovative Approaches to Sensitive Question Surveys: A Hybrid Binary Model Using Paillier Encryption and Randomized Response Techniquesnohttps://cassyni.com/events/MxgigcMiogjS3qGq2WMGJy?videoPreview=12024-11-26T16:00:00+00:003213.84Journal of Statistical Theory and PracticeIn sensitive question surveys, respondent privacy is a major concern that can influence both participation rates and data accuracy. The key concern is the tendency of the respondents to lie or to not respond to the question of sensitive nature due to a fear of judgment of the surveyor. Traditional methods, such as the Randomized Response Technique (RRT), help preserve privacy but may compromise estimation accuracy. On the other hand, Paillier encryption—a widely used asymmetric encryption protocol—offers high security and perfect accuracy but can be computationally expensive and still relies on the integrity of the decryption key holder. In this webinar, we introduce a novel hybrid model combining the Paillier encryption scheme with Warner's Randomized Response Technique (RRT) as an attempt to enhance both privacy and efficiency in the process of data collection for sensitive binary response questions. Participants will gain insights into: - The fundamental attributes of the Paillier encryption protocol and its application in secure data collection. - The fundamentals of RRT for mitigating social desirability bias in sensitive questions. - The structure and benefits of a hybrid Paillier-RRT model. - Simulation results illustrating the model&#39;s performance in terms of Mean Squared Error (MSE). - A discussion on the concept of overall privacy under the hybrid Paillier-RRT model. This webinar is ideal for statisticians, data scientists, and researchers interested in advancing secure and accurate methods for surveying sensitive topics.https://cassyni-user-files-prod.s3.amazonaws.com/Gnj6PbM5uodjtDVzmdBbUi https://cassyni.com/events/D51qrJiGuSmFs56ocv4Dyw/seminar/qa https://cassyni.com/slides/outline/D51qrJiGuSmFs56ocv4Dyw https://cassyni.com/events/D51qrJiGuSmFs56ocv4Dyw/abstract https://cassyni-user-files-prod.s3.amazonaws.com/2TDrNHQQc8XCuRfMycKXZg https://cassyni.com/events/D51qrJiGuSmFs56ocv4Dyw?videoPreview=1 Systemwide characterization of the ERK program that drives pancreatic cancernohttps://cassyni.com/events/D51qrJiGuSmFs56ocv4Dyw?videoPreview=12025-05-15T18:00:00+00:003295.64Center for Cancer TrainingOver 95% of pancreatic ductal adenocarcinoma (PDAC) tumors harbor a KRAS mutation and nearly half are KRASG12D. Therefore, advancement of KRASG12D and RASMULTI ON inhibitors into the clinic will have a major impact on treating one of the deadliest cancers. However, treatment-associated resistance to currently approved KRAS inhibitors has emerged, with ~60% of relapsed patients acquiring mutations that reactivate the RAF-MEK-ERK and PI3K-AKT effector pathways. We found that ectopic expression of constitutively activated MEK1 kinase (MEK1- DD), ERK1 (ERK1-SD) or ERK2 (ERK2-SD) kinases, but not AKT1 (myr-AKT) kinase, drove near-complete resistance to direct inhibitors of KRAS in PDAC. Consistent with this, we found that treatment with either RASMULTI ON (RMC-7977), KRASG12D (MRTX1133), MEK (trametinib), or ERK (SCH772984) inhibitors induced nearly identical transcriptomic changes in PDAC. These observations prompted us to define the mechanistic basis for ERK-dependent growth in KRAS mutant PDAC. Ectopic expression of either constitutively active ERK1 or ERK2 was sufficient to rescue 92% (ERK1) or 83% (ERK2) of KRAS mediated transcription. Combined with genetic-loss-of function studies, we demonstrated that ERK1 and ERK2 are functionally identical in KRAS-mutant PDAC. Many ERK substrates are characterized by two ERK docking sequences, the DEF and D motifs. We identified 2,123 ERK-dependent phosphoproteins, with ~40% containing DEF and/or D-motifs. To address how each of these docking motifs contributes to mutant KRAS-ERK driven signaling in PDAC, we generated mutations in constitutively active ERK1 and ERK2 that prohibited ERK interaction with either of the two substrate docking motifs. We found that both DEF and D-motif interactions were required to rescue PDAC cell growth following MEK inhibition (trametinib) or KRAS inhibition (MRTX1133). Our studies establish ERK as the key driver of KRAS-dependent cancer growth, regulating a complex transcriptome and phosphoproteome that is reliant on ERK’s ability to recognize two docking motifs. https://cassyni-user-files-prod.s3.amazonaws.com/2TDrNHQQc8XCuRfMycKXZg https://cassyni.com/events/HWsuP63tFvgEUCYzp8mEm3/seminar/qa https://cassyni.com/slides/outline/HWsuP63tFvgEUCYzp8mEm3 https://cassyni.com/events/HWsuP63tFvgEUCYzp8mEm3/abstract https://cassyni-user-files-prod.s3.amazonaws.com/QqA3qumu4CHziCD36fHSjQ https://cassyni.com/events/HWsuP63tFvgEUCYzp8mEm3?videoPreview=1 The Role of Global Dynamics in Analysis, Control and Safe Designnohttps://cassyni.com/events/HWsuP63tFvgEUCYzp8mEm3?videoPreview=12025-02-18T14:00:00+00:002562.64Nonlinear Dynamics, an International Journal of Nonlinear Dynamics and Chaos in Engineering SystemsGlobal nonlinear dynamics has been evolving in a revolutionary way in about the last two decades, with development of sophisticated techniques employing concepts/tools of dynamical systems, bifurcation, and chaos theory, and applications to a wide variety of mechanical/structural systems. Relevant achievements entail a substantial change of perspective in dealing with vibration problems, and are ready to affect significantly the analysis, control, and safe design of systems at different scales. Upon framing the topic within the hystorical development of nonlinear dynamics in solid/structural mechanics, the seminar focuses on highlighting the role played by global analysis in unveiling the nonlinear response and actual safety of engineering systems in diverse environments. Reduced order models of macro/micro-structures are considered to illustrate a few objectives. ----------- ### Key Learning Objectives - Unveiling effects of fast/mechanical-slow/thermal coupling on long-term dynamics - Assessing robustness and overall stability of mechanical/structural systems via dynamical integrity - Leveraging global concepts/phenomena for control purposes - Predicting global safety mismatches due to practical conditions or - locally-tailored control - Dealing with non-deterministic systems: attractors distributions and basins of attraction - Enhancing load carrying capacity via a global dynamics-informed paradigm both safe and reliable - Exploiting refined nonlinear model reduction to face global dynamics of high-dimensional systems ### Who Should Attend - Researchers/scientists in applied mechanics and nonlinear dynamics of structures and systems - Mechanical and structural engineershttps://cassyni-user-files-prod.s3.amazonaws.com/QqA3qumu4CHziCD36fHSjQ https://cassyni.com/slides/outline/KyHFBcpvNPey7jJtk3o1bT https://cassyni.com/events/KyHFBcpvNPey7jJtk3o1bT/abstract https://cassyni-user-files-prod.s3.amazonaws.com/A2uUWBJ7bPAsHamEhujbDG https://cassyni.com/events/KyHFBcpvNPey7jJtk3o1bT?videoPreview=1 High-fidelity vortex-induced vibration of a wind turbine blade under extreme conditionsnohttps://cassyni.com/events/KyHFBcpvNPey7jJtk3o1bT?videoPreview=12022-09-15T08:00:00+00:001715.04NEKTAR++Modern wind turbines are put to the stand-still state under certain conditions such as above-design wind speeds or scheduled maintenance. In such situations the blade is prone to experiencing the incoming wind flow with a very high angle of attack that could lead to massive separation and development and shedding vortices from the blade, resulting in an unsteady loading on the blade structure. Further, due to the large size and hence enhanced flexibility of modern wind turbine blades, this unsteady loading of the flow together with the aeroelastic response of the blade could result in vibration of the blade in such conditions which is known as the stand-still vibration. In this talk, the simulation results of the stand-still vibration of the NREL 5MW blade under high wind speed condition will be presented. Simulations are performed using a recently developed fluid-structure solver that has been implemented in the Nektar++ framework and is based on the coupling with the uDNS incompressible Navier-Stokes solver of Nektar++ and Geometrically-Exact composite beam (GECB) beam solver of SHARPy library.https://cassyni-user-files-prod.s3.amazonaws.com/A2uUWBJ7bPAsHamEhujbDG https://cassyni.com/slides/outline/CeHReEygzcU5T8qptjc8V https://cassyni.com/events/CeHReEygzcU5T8qptjc8V/abstract https://cassyni-user-files-prod.s3.amazonaws.com/TmLFnLVVYDu61sbbnz6rfg https://cassyni.com/events/CeHReEygzcU5T8qptjc8V?videoPreview=1 Freezing a rivuletnohttps://cassyni.com/events/CeHReEygzcU5T8qptjc8V?videoPreview=12021-06-11T15:00:00+00:001338.92Journal of Fluid MechanicsWe investigate experimentally the formation of the particular ice structure obtained when a capillary trickle of water flows on a cold substrate. We show that after a few minutes the water ends up flow-ing on a tiny ice wall whose shape is permanent. We characterize and understand quantitatively the formation dynamics and the final thickness of this ice structure. In particular, we identify two growth regimes. First, a 1D solidification diffusive regime, where ice is building independently of the flowing water. And second, once the ice is thick enough, the heat flux in the water comes into play, breaking the 1D symmetry of the problem, and the ice ends up thickening linearly downward. This linear pattern is explained by considering the competition between the water cooling and its convection.https://cassyni-user-files-prod.s3.amazonaws.com/TmLFnLVVYDu61sbbnz6rfg https://cassyni.com/slides/outline/3ftJf4UbtHNxSPcQNaeErR https://cassyni.com/events/3ftJf4UbtHNxSPcQNaeErR/abstract https://cassyni-user-files-prod.s3.amazonaws.com/NLCcGpNiiBoeDFFasFyES2 https://cassyni.com/events/3ftJf4UbtHNxSPcQNaeErR?videoPreview=1 Engines of life: self-pumping, bio-inspired fluidsnohttps://cassyni.com/events/3ftJf4UbtHNxSPcQNaeErR?videoPreview=12021-02-05T16:00:00+00:003699.04Journal of Fluid MechanicsSperms, bacteria, and tissues, all work as engines of life converting chemical energy into motion. These systems are known as active materials and are capable of self-pumping with prominent role in biological processes, from organ formation to tumor progression. A generic property of active fluids is the spontaneous emergence of collective flows, which often leads to chaotic flow patterns characterized by swirls, jets, and topological disclinations in their orientation field. I will first discuss examples of these collective flows helping us understand biological processes. I will then discuss various strategies to tame, otherwise chaotic, active flows, showing how hydrodynamic screening of active flows can act as a robust way of controlling and guiding active particles into dynamically ordered coherent structures. I will also explain how combining hydrodynamics with topological constraints can lead to further control of exotic morphologies of active shells.https://cassyni-user-files-prod.s3.amazonaws.com/NLCcGpNiiBoeDFFasFyES2 https://cassyni.com/slides/outline/G26Qp9eirjDpL4rDLwCxzZ https://cassyni.com/events/G26Qp9eirjDpL4rDLwCxzZ/abstract https://cassyni-user-files-prod.s3.amazonaws.com/2RCyw1ymjJrM4isRnAfqYz https://cassyni.com/events/88ZRW6kuvE9gZ8WXQPwJCm/seminar/qa https://cassyni.com/slides/outline/88ZRW6kuvE9gZ8WXQPwJCm https://cassyni.com/events/88ZRW6kuvE9gZ8WXQPwJCm/abstract https://cassyni-user-files-prod.s3.amazonaws.com/8fBwmUPnwoT9FCcpQks6bQ https://cassyni.com/events/88ZRW6kuvE9gZ8WXQPwJCm?videoPreview=1 Assembly Modulation: An Emergent Drug Discovery Strategy Revealed by Viruses and Applicable Across Therapeutic Areasnohttps://cassyni.com/events/88ZRW6kuvE9gZ8WXQPwJCm?videoPreview=12025-03-05T17:00:00+00:005286.12Royal Society PublishingEvolution through natural selection is the most powerful force we know of in biology. Perhaps its most adept practitioners are viruses, particularly retroviruses. Approximately 8% of the human genome(1), and numerous physiological innovations from cognition(2) to the placenta(3), are likely due to ancient retroviral infections, a testimony to how they have shaped who we are as a species. A set of methods have been developed(4) which effectively turn viruses into “trufflehounds”(5) to reveal the high value molecular targets that viruses utilized to redirect a host cell’s protein machinery to depart from homeostasis (the balance that characterizes good health), and serve instead, the needs of the virus(6). We leveraged the viral discovery of functional targets(7), through phenotypic drug screens for for disruption of viral assembly(8), to enable identification of functional compounds, with which we have made several notable observations. First, that these drugs show efficacy in cells and animals(9,10,11). Second, we find that the same targets in our biology that viruses have exploited, are the ones that break in non-viral diseases, including cancer and neurodegeneration(12,13). Third, it appears that these drugs bind to allosteric sites, the natural control panels by which enzymes evolved to be regulated, but which have proven fiendishly difficult to identify directly by human tools(14,15). Finally, these compounds appear to have remarkable properties (e.g. barrier to viral resistance development, see references 9, 16) and may enable currently impossible clinical therapeutic strategies(9). Compounds with these features, active against various viral and non-viral disorders, are being advanced. Along the way they are revealing new features of biology. Two papers published last year in Open Biology, are the focus of this webinar. The first on a small molecule active against all of the major viral families causing human respiratory tract disease, including influenza, RSV and SARS-CoV-2, and the second paper on a small molecule active against all of over 80 different tumor cell lines, including all cancers in the National Cancer Institute’s 60 cancer screen. Each of these compounds binds to a novel, unconventional target: different transient, energy-dependent multi-protein complexes, composed of miniscule subsets of their component proteins present in the cell. These features make them hard to detect by genomic or conventional proteomic methods and are consistent with protein "moonlighting"(17). This webinar will review the available data and connect to broader questions, biochemical and clinical, with regards to human health and disease. References cited above 1. Markovitz DM. "Reverse genomics" and human endogenous retroviruses. Trans Am Clin Climatol Assoc. 2014;125:57-62; discussion 62-3. PMID: 25125718; PMCID: PMC4112691. 2. Campioni MR, Finkbeiner S. Going retro: ancient viral origins of cognition. Neuron. 2015 Apr 22;86(2):346-8. doi: 10.1016/j.neuron.2015.04.008. PMID: 25905805. 3. Zhang X, Muglia LJ. Baby's best Foe-riend: Endogenous retroviruses and the evolution of eutherian reproduction. Placenta. 2021 Sep 15;113:1-7. doi: 10.1016/j.placenta.2021.02.011. 4. Lingappa VR, Lingappa JR. Recent insights into biological regulation from cell-free protein-synthesizing systems. Mt Sinai J Med. 2005 May;72(3):141-60. PMID: 15915309. 5. Müller-Schiffmann A, et al. Viruses as 'Truffle Hounds': Molecular Tools for Untangling Brain Cellular Pathology. Trends Neurosci. 2021 May;44(5):352-365. doi: 10.1016/j.tins.2020.11.004. 6. Charvet B, et al. SARS-CoV-2 awakens ancient retroviral genes and the expression of proinflammatory HERV-W envelope protein in COVID-19 patients. iScience. 2023 May 19;26(5):106604. doi: 10.1016/j.isci.2023.106604. 7. Goodwin CM, Xu S, Munger J. Stealing the Keys to the Kitchen: Viral Manipulation of the Host Cell Metabolic Network. Trends Microbiol. 2015 Dec;23(12):789-798. doi: 10.1016/j.tim.2015.08.007. 8. Lingappa UF, et al. Host-rabies virus protein-protein interactions as druggable antiviral targets. Proc Natl Acad Sci U S A. 2013 Mar 5;110(10):E861-8. doi: 10.1073/pnas.1210198110. 9. Michon M, et al. A pan-respiratory antiviral chemotype targeting a transient host multi-protein complex. Open Biol. 2024 Jun;14(6):230363. doi: 10.1098/rsob.230363. 10. Du L, et al. A viral assembly inhibitor blocks SARS-CoV-2 replication in airway epithelial cells. Commun Biol. 2024 Apr 22;7(1):486. doi: 10.1038/s42003-024-06130-8. PMID: 38649430; PMCID: PMC11035691. 11. Lingappa AF, et al. Small molecule protein assembly modulators with pan-cancer therapeutic efficacy. Open Biol. 2024 Dec;14(12):240210. doi: 10.1098/rsob.240210. 12. Müller-Schiffmann A, et al. Oxidized MIF is an Alzheimer’s Disease drug target relaying external risk factors to tau pathology. bioRxiv 2021.09.11.459903; doi: https://doi.org/10.1101/2021.09.11.459903 13. Lingappa AF et al Structure-Activity-Relationship Exploration and Animal Validation of Novel Assembly Modulator Small Molecule Chemical Series with Pan-Cancer Selective Cytotoxicity. bioRxiv 2025.02.28.640839;  doi: https://doi.org/10.1101/2025.02.28.640839 14. Fenton AW. Allostery: an illustrated definition for the 'second secret of life'. Trends Biochem Sci. 2008 Sep;33(9):420-5. doi: 10.1016/j.tibs.2008.05.009. 15. Alblova M, et al. Molecular basis of the 14-3-3 protein-dependent activation of yeast neutral trehalase Nth1. Proc Natl Acad Sci U S A. 2017 Nov 14;114(46):E9811-E9820. doi: 10.1073/pnas.1714491114. 16. Reed JC, et al. Identification of an Antiretroviral Small Molecule That Appears To Be a Host-Targeting Inhibitor of HIV-1 Assembly. J Virol. 2021 Jan 16. 13;95(3):e00883-20. doi: 10.1128/JVI.00883-20. PMID: 33148797; PMCID: PMC7925099. 17. Jeffery CJ. Enzymes, pseudoenzymes, and moonlighting proteins: diversity of function in protein superfamilies. FEBS J. 2020 Oct;287(19):4141-4149. doi: 10.1111/febs.15446. Epub 2020 Jun 30. PMID: 32534477. https://cassyni-user-files-prod.s3.amazonaws.com/8fBwmUPnwoT9FCcpQks6bQ https://cassyni.com/slides/outline/AaxmJdXx2h8jwCbyk2DB17 https://cassyni.com/events/AaxmJdXx2h8jwCbyk2DB17/abstract https://cassyni-user-files-prod.s3.amazonaws.com/2kLp56W87t14DFZYsRAzSA https://cassyni.com/events/AaxmJdXx2h8jwCbyk2DB17?videoPreview=1 Optomagnetism in plasmonic nanostructuresnohttps://cassyni.com/events/AaxmJdXx2h8jwCbyk2DB17?videoPreview=12022-07-07T07:40:00+00:00718.04ETOPIMOptically-induced magnetism has drawn considerable interest in the past years for its ability to speed up magnetic processes. For example, static magnetic fields have been demonstrated to be generated in non-magnetic plasmonic (gold) nanoparticles and nano-apertures [1]. Such a phenomenon has been analyzed as the result of the inverse Faraday effect. Inverse Faraday effect in plasmonic structures can be predicted with a hydrodynamic description of the free electron gas of a metal [2]. More generally, the hydrodynamic model provides reference equations for describing optical nonlinearities in plasmonic nanostructures [3]. It is usually admitted that the inverse Faraday effect (IFE) originates from the spin angular momentum (SAM) of light. We evidence that part of the IFE in metals is induced by the orbital angular momentum (OAM) of light[4]. Using a simplified hydrodynamic model of the free electron gas of a metal, we theoretically investigate the IFE and resulting optomagnetism in a thin gold film as well as in axis-symmetric plasmonic nanostructures under illumination with various focused light beams carrying spin and/or orbital angular momenta [5, 6]. The resulting static magnetic field exhibits resonant behaviour and found to be maximum and dramatically confined at the corners and edges of the plasmonic structures, which reveals the ability of metallic discontinuities to concentrate and tailor static magnetic fields on the nanoscale. Plasmonics can thus generate and tune static magnetic fields and strong magnetic forces on the nanoscale, potentially impacting small scale magnetic tweezing and sensing as well as the generation of magneto-optical effects and spin-waves.https://cassyni-user-files-prod.s3.amazonaws.com/2kLp56W87t14DFZYsRAzSA https://cassyni.com/slides/outline/B5cNMKBUU9gnvy8sLTVyGR https://cassyni.com/events/B5cNMKBUU9gnvy8sLTVyGR/abstract https://cassyni-user-files-prod.s3.amazonaws.com/R8ShfEvJTnrud5qY4XrPsC https://cassyni.com/events/B5cNMKBUU9gnvy8sLTVyGR?videoPreview=1 Topological photonics and phononics from a multi-band perspectivenohttps://cassyni.com/events/B5cNMKBUU9gnvy8sLTVyGR?videoPreview=12022-07-08T09:40:00+00:001740.04ETOPIMTopological phases are usually classified by global topological invariants which are integers, such as Chern numbers in 2D or winding numbers in 1D. We will use some examples to illustrate that we can have topological systems that are characterized by non-Abelian entities such as quaternions.https://cassyni-user-files-prod.s3.amazonaws.com/R8ShfEvJTnrud5qY4XrPsC https://cassyni.com/slides/outline/HziT7Wki1vNJaFpqzU1M3j https://cassyni.com/events/HziT7Wki1vNJaFpqzU1M3j/abstract https://cassyni-user-files-prod.s3.amazonaws.com/QBddCP3wMet1Ux7Fn2QCyU https://cassyni.com/events/HziT7Wki1vNJaFpqzU1M3j?videoPreview=1 A scaling theory for meridional heat transport in oceans and planetary atmospheresnohttps://cassyni.com/events/HziT7Wki1vNJaFpqzU1M3j?videoPreview=12020-10-02T15:00:00+00:003725.84Journal of Fluid MechanicsDeveloping a theory of climate requires an accurate parameterization of the transport induced by turbulent eddies. A major source of turbulence in the mid-latitude planetary atmospheres and oceans is the baroclinic instability of the large-scale flows. I will introduce idealized models of planetary atmospheres and oceanic currents, before presenting a physically based scaling theory that quantitatively predicts the turbulent diffusivity, eddy kinetic energy and mixing length of baroclinic turbulence as a function of the large-scale flow characteristics, the bottom friction and the curvature of the planet (through beta). I will then use the theory as a quantitative parameterization in the case of meridionally dependent forcing, in the fully turbulent regime. Beyond its relevance for climate theories, this work is an intriguing example of a successful closure for a fully turbulent flow.https://cassyni-user-files-prod.s3.amazonaws.com/QBddCP3wMet1Ux7Fn2QCyU https://cassyni.com/slides/outline/Uryk8YzFfzYn6Xesc1F2zZ https://cassyni.com/events/Uryk8YzFfzYn6Xesc1F2zZ/abstract https://cassyni-user-files-prod.s3.amazonaws.com/UkiXFGxL1Sf7pXwpnbyMEW https://cassyni.com/events/Uryk8YzFfzYn6Xesc1F2zZ?videoPreview=1 Smart Textiles for Personalized Health Carenohttps://cassyni.com/events/Uryk8YzFfzYn6Xesc1F2zZ?videoPreview=12022-12-23T02:30:00+00:002912.96Mechanical EngineeringHealth care should move from its current reactive and disease-centric system to a personalized, predictive, preventative, and participatory model with a focus on disease prevention and health promotion.[1] As the world marches into the era of the Internet of Things (IoT) and 5G wireless, technology renovation enables the industry to offer a more individually tailored approach to healthcare with better health outcomes, higher quality, and lower cost.[2] However, empowering the utility of IoT-enabled technologies for personalized health care is still significantly challenged by the shortage of cost-effective on-body biomedical devices to continuously provide real-time, patient-generated health data.[3,4] Textiles have been concomitant and played a vital role in the long history of human civilization. Merging biomedical devices and textiles becomes increasingly important owing to the growing trend of IoT since it could serve as on-body healthcare platforms with incomparable wearing comfort. In this talk, I will introduce our current research on smart textiles for biomonitoring, [5-8] therapeutics,[9] power supply,[10,11] and textiles body area network for personalized health care[12-14].https://cassyni-user-files-prod.s3.amazonaws.com/UkiXFGxL1Sf7pXwpnbyMEW https://cassyni.com/slides/outline/6doZ3nsdvPdKJ1qhdUZa2q https://cassyni.com/events/6doZ3nsdvPdKJ1qhdUZa2q/abstract https://cassyni-user-files-prod.s3.amazonaws.com/LtvBECLHv9zaVAEEZiR8CN https://cassyni.com/events/6doZ3nsdvPdKJ1qhdUZa2q?videoPreview=1 Learning developmental path signature features with deep learning framework for infant cognitive scores predictionnohttps://cassyni.com/events/6doZ3nsdvPdKJ1qhdUZa2q?videoPreview=12021-04-21T09:00:00+00:002425.28DataSıgPath signature has unique advantages on extracting high-order differential features of sequential data. Our team has been studying the path signature theory and actively applied it to various applications, including infant cognitive score prediction, human motion recognition, hand-written character recognition, hand-written text line recognition and writer identification etc. In this talk, I will share our most recent works on infant cognitive score prediction using deep path signature. The cognitive score can reveal individual’s abilities on intelligence, motion, language abilities. Recent research discovered that the cognitive ability is closely related with individual’s cortical structure and its development. We have proposed two frameworks to predict the cognitive score with different path signature features. For the first framework, we construct the temporal path signature along the age growth and extract signature features of developmental infant cortical features. By incorporating the cortical path signature into the multi-stream deep learning model, the individual cognitive score can be predicted with missing data issues. For the second framework, we propose deep path signature algorithm to compute the developmental feature and obtain the developmental connectivity matrix. Then we have designed the graph convolutional network for the score prediction. These two frameworks have been tested on two in-house cognitive data sets and reached the state-of-the-art results.https://cassyni-user-files-prod.s3.amazonaws.com/LtvBECLHv9zaVAEEZiR8CN https://cassyni.com/slides/outline/E3Xck3aWWFw9nbNAbMRJSq https://cassyni.com/events/E3Xck3aWWFw9nbNAbMRJSq/abstract https://cassyni-user-files-prod.s3.amazonaws.com/UqD8X37nbeigLqJLviEJKp https://cassyni.com/events/E3Xck3aWWFw9nbNAbMRJSq?videoPreview=1 Improving quality of life post-tumor craniotomy using personalized, parcel-guided TMS: safety and proof of conceptnohttps://cassyni.com/events/E3Xck3aWWFw9nbNAbMRJSq?videoPreview=12023-01-16T21:00:00+00:001557.8Journal of Neuro-OncologyDr. Randy D'Amico and Dr. Jason Sheehan from the Journal of Neuro-Oncology sit down with Assistant Professor of Neurosurgery from the Yale School of Medicine, Dr. Jacky Yeung, to discuss how to improve quality of life post-tumor craniotomy using personalized, parcel-guided TMS.https://cassyni-user-files-prod.s3.amazonaws.com/UqD8X37nbeigLqJLviEJKp https://cassyni.com/slides/outline/973aHD7G7gQ8PVepasiJih https://cassyni.com/events/973aHD7G7gQ8PVepasiJih/abstract https://cassyni-user-files-prod.s3.amazonaws.com/7AC2GaaWXxj2ZqwnRToQL6 https://cassyni.com/events/973aHD7G7gQ8PVepasiJih?videoPreview=1 Celebrating the launch of Nature Water - Part 4: Focus on groundwaternohttps://cassyni.com/events/973aHD7G7gQ8PVepasiJih?videoPreview=12023-02-02T15:00:00+00:003747.28Nature WaterTo celebrate the launch of Nature Water, we have organized a series of webinars with some of the authors from the first issue. In this fourth webinar, editor Yanhua Chen will be talking to Oliver Schilling about deep groundwater contribution to Fuji’s springs and with Meagan Schipanski about her work on groundwater governance.https://cassyni-user-files-prod.s3.amazonaws.com/7AC2GaaWXxj2ZqwnRToQL6 https://cassyni.com/events/3C5P3GHfXecfA2oBPvEJUd/abstract https://cassyni-user-files-prod.s3.amazonaws.com/D4EpvpQxywLSDpQjwyGupJ https://cassyni.com/events/DZh51csgkGF5gY6KR2BCA9/abstract https://cassyni-user-files-prod.s3.amazonaws.com/WDY5bPeDgJzmgXA1p4cVYa https://cassyni.com/events/A79qgqM1g4NSeqnkmMoEdK/seminar/qa https://cassyni.com/slides/outline/A79qgqM1g4NSeqnkmMoEdK https://cassyni.com/events/A79qgqM1g4NSeqnkmMoEdK/abstract https://cassyni-user-files-prod.s3.amazonaws.com/UUzR5juYCsgMJqn4qsSTfL https://cassyni.com/events/A79qgqM1g4NSeqnkmMoEdK?videoPreview=1 Development of a Generalizable Data-Driven Turbulence Model: Conditioned Field Inversion and Symbolic Regressionnohttps://cassyni.com/events/A79qgqM1g4NSeqnkmMoEdK?videoPreview=12025-07-08T13:00:00+00:003767.16AIAA JournalThis seminar presents a series of interpretable and generalizable data-driven methods for turbulence modeling. The Reynolds-averaged Navier-Stokes (RANS) equations are widely used in engineering, but their turbulence models often struggle with separated flows. While recent advances in data-driven techniques have improved model accuracy in complex separated flows, these models frequently lack interpretability and generalizability, sometimes even reducing accuracy in simple wall-attached flows. Our first approach integrates symbolic regression (SR) with the field inversion and machine learning (FIML) framework to derive an interpretable analytical expression for the correction term β using field inversion data. This expression demonstrates generalizability across diverse cases, including 3D separated flows not included in the training set. However, it occasionally fails to consistently maintain the baseline model's accuracy in wall-attached flows. To address this limitation, we introduce a conditioned field inversion approach that confines corrections to regions outside the attached boundary layer. The resulting SR-CND model retains the capability of correcting separated flows comparably to classical field inversion, while preserving accuracy in attached boundary layers - a feature lacking in the classical method. This model has been validated through several 2D and 3D cases, including configurations from the high-lift prediction workshops (HPWs). Results demonstrate that the flow separation prediction accuracy is superior to that of the baseline model. Finally, we propose a non-local modeling approach to further enhance generalizability. By constructing a transport equation for the correction term β and calibrating its parameters for separated flows using data-driven methods, this model shows improved accuracy in various separated flows compared to the SR-CND model.https://cassyni-user-files-prod.s3.amazonaws.com/UUzR5juYCsgMJqn4qsSTfL https://cassyni.com/events/CaPrvFadsM8w1nGKK3hsMF/abstract https://cassyni-user-files-prod.s3.amazonaws.com/DCTrhJJWAeCHkDdRbQDTZg https://cassyni.com/events/PSgn3vL4vnF8gXnkD9szvh/abstract https://cassyni-user-files-prod.s3.amazonaws.com/5kJ8kRGbnt7xvh5pXzpZti https://cassyni.com/events/RRHCEevAgcTtnF4ya7jwMF/seminar/qa https://cassyni.com/slides/outline/RRHCEevAgcTtnF4ya7jwMF https://cassyni.com/events/RRHCEevAgcTtnF4ya7jwMF/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Gz1sMEsDAFspDSamUxaWaS https://cassyni.com/events/RRHCEevAgcTtnF4ya7jwMF?videoPreview=1 Micromechanics of Composites: Asymptotic Homogenization and Metamaterialsnohttps://cassyni.com/events/RRHCEevAgcTtnF4ya7jwMF?videoPreview=12025-03-25T14:00:00+00:003760.4Department of AeronauticsAn issue of a high significance in micromechanics of composites is determination of effective properties depending on the spatial distribution, geometric characteristics and mechanical properties of the constituents. Various asymptotic approaches to the analysis of composites have reached their conclusion in the multi-scale asymptotic homogenization. The proof of the possibility of homogenizing the composite material of a regular structure is one of the principal results of this theory. Asymptotic homogenization method has also indicated a method of transition from the original problem for the inhomogeneous composite to a problem for a homogeneous material described by a set of the effective properties. This transition is accomplished through the solution of the unit cell local problems that allows determining the effective properties and distribution of displacements and stresses. The presentation will cover the basics of asymptotic homogenization. Simple examples will be used to illustrate the asymptotic homogenization technique. The general asymptotic homogenization models will be further introduced and applied to the analysis of composite materials and thin-walled composite structures of a practical importance, including wafer-reinforced shells, composite grids, sandwich shells and carbon nanotubes. Final part of presentation will address new developments in the analysis, design and fabrication of lightweight composite metamaterials and cellular structures.https://cassyni-user-files-prod.s3.amazonaws.com/Gz1sMEsDAFspDSamUxaWaS https://cassyni.com/slides/outline/JVXnqyVYsYUm8QtDBFRrcD https://cassyni.com/events/JVXnqyVYsYUm8QtDBFRrcD/abstract https://cassyni-user-files-prod.s3.amazonaws.com/PLL6djigy4Tv7i3epMAJXg https://cassyni.com/events/JVXnqyVYsYUm8QtDBFRrcD?videoPreview=1 Cross-Dehydrogenative Couplingnohttps://cassyni.com/events/JVXnqyVYsYUm8QtDBFRrcD?videoPreview=12024-02-15T11:00:00+00:008000.84Thieme GroupDiscover Cross-Dehydrogenative Coupling in our next Thieme WebCheminar with our speakers Debabrata Maiti, Editor of the recent Science of Synthesis volume, Suman De Sarkar (India), Tatiana Besset (France) and Bert Maes (Belgium).https://cassyni-user-files-prod.s3.amazonaws.com/PLL6djigy4Tv7i3epMAJXg https://cassyni.com/events/69zdRzghZks21f2Uep9df3/seminar/qa https://cassyni.com/slides/outline/69zdRzghZks21f2Uep9df3 https://cassyni.com/events/69zdRzghZks21f2Uep9df3/abstract https://cassyni-user-files-prod.s3.amazonaws.com/93KggSVAWK2yvg6WzUcZ3c https://cassyni.com/events/69zdRzghZks21f2Uep9df3?videoPreview=1 Elastic Metamaterials for Wave Mode Conversion, Dispersion Engineering, and Topological Wave Localization Across Scalesnohttps://cassyni.com/events/69zdRzghZks21f2Uep9df3?videoPreview=12025-06-03T13:00:00+00:004227.76MetaMATWave control along elastic substrates dominates applications from large-scale geophysical contexts and mechanical vibrations to micro/nanometer on-chip devices, spintronics, and RF filters. The intrinsic complexity of elastic systems, supporting different wave modes, allows the design of structures capable of engineering their coupling, tailoring their group velocity, polarization, and propagation direction. The talk will focus on wave mode coupling as a design tool in elasticity to focus waves in controlled directions, tailor spatial energy distribution, and localize them. After introducing the framework, specific attention will be devoted to showing the advantages of exploiting wave mode conversion in topological systems, highlighting the enhanced localization capabilities that can be achieved. A direct link with applications will be emphasized, particularly in the areas of energy harvesting and radio frequency microelectromechanical systems (RF MEMS).https://cassyni-user-files-prod.s3.amazonaws.com/93KggSVAWK2yvg6WzUcZ3c https://cassyni.com/events/Abq4r9WRWsrGUJnGZTvCoX/seminar/qa https://cassyni.com/slides/outline/Abq4r9WRWsrGUJnGZTvCoX https://cassyni.com/events/Abq4r9WRWsrGUJnGZTvCoX/abstract https://cassyni-user-files-prod.s3.amazonaws.com/6JFgrbn2DUAcMCRioGLTJv https://cassyni.com/events/Abq4r9WRWsrGUJnGZTvCoX?videoPreview=1 Geomechanics from Micro to Macro in Space-soil engineeringnohttps://cassyni.com/events/Abq4r9WRWsrGUJnGZTvCoX?videoPreview=12025-04-30T13:00:00+00:004543.04Granular MatterWhite paper "China's Space Program: A 2021 Perspective" has unveiled new deep-space exploration missions, including the construction of a lunar research station, Mars and asteroid exploration and sampling etc., which involve a series of studies on the mechanical and engineering properties of space soils (lunar soil, Martian soil, and asteroid soil) and the interactions between these soils and equipment under the complex environments of deep space. This report will mainly present the micro constitutive model for space soil, the mechanism of problematic behaviours and the mechanical properties of TJ-1 lunar soil simulant, TJ-M1 Martian soil simulant and asteroid soil simulant developed for China's deep-space exploration projects, and further elucidates the effects of complex space environments (high vacuum, low gravity, etc.) on the engineering properties (CPT and plate load test) of lunar soil and the interactions between lunar soil and equipment (lunar rover and excavation), aiming to provide references for the successful implementation of China's deep space exploration missions.https://cassyni-user-files-prod.s3.amazonaws.com/6JFgrbn2DUAcMCRioGLTJv https://cassyni.com/events/MTg29k1g8Y8qo7aRveTw3s/seminar/qa https://cassyni.com/slides/outline/MTg29k1g8Y8qo7aRveTw3s https://cassyni.com/events/MTg29k1g8Y8qo7aRveTw3s/abstract https://cassyni-user-files-prod.s3.amazonaws.com/7T8i3BKYiFWCEj741Hspwx https://cassyni.com/events/MTg29k1g8Y8qo7aRveTw3s?videoPreview=1 Explaining synthetic face images generated by diffusion modelsnohttps://cassyni.com/events/MTg29k1g8Y8qo7aRveTw3s?videoPreview=12025-05-06T13:00:00+00:003004.04Journal on Image and Video ProcessingIn this talk, I will introduce a state-of-the-art approach designed to explain face images generated by diffusion models. Specifically, I will introduce the Explainable DIffusion PRobabilistic (EDIPR) model, which is based on a classification framework. EDIPR consists of three stages: an initial clustering stage, which serves as the pre-processing step to discover groups of similar face images in the training set; a synthesizing stage, carried out by a diffusion model; and an explaining stage, which allows determining which training images contributed the most to the generation of a new face image. To provide explainability, I will also introduce two influence scores as quantitative metrics: the Normalized Influence Score (NIS) and the class-Normalized Influence Score (cNIS). These scores provide the probability that a specific training image, or class, contributes to the generation of a synthetic face image. Based on synthetic images generated using real images of the FFHQ dataset as training data, I will show that EDIPR provides robust and plausible explanations linking the training images to the synthetic images at three levels of granularity: the region, the image, and the class level.https://cassyni-user-files-prod.s3.amazonaws.com/7T8i3BKYiFWCEj741Hspwx https://cassyni.com/events/6eDtmEbvxoXDVBHiuzeCW9/seminar/qa https://cassyni.com/slides/outline/6eDtmEbvxoXDVBHiuzeCW9 https://cassyni.com/events/6eDtmEbvxoXDVBHiuzeCW9/abstract https://cassyni-user-files-prod.s3.amazonaws.com/MEaTrC82qcVSrXfmawYJ78 https://cassyni.com/events/6eDtmEbvxoXDVBHiuzeCW9?videoPreview=1 Black, Queer, and Fabulous: Reclaiming Joy Through Fiercenessnohttps://cassyni.com/events/6eDtmEbvxoXDVBHiuzeCW9?videoPreview=12025-07-17T17:00:00+00:003018.44Lived Places PublishingBeing Black and queer from the inner city has both moments of pain and joy. In these lived experiences, **David B. Green Jr.** has learned to reclaim joy through "fierceness," which is something hard-won and deserving of celebration. This session serves a celebration of sorts, demonstrating how Black queer people can discover meaning and acceptance. https://cassyni-user-files-prod.s3.amazonaws.com/MEaTrC82qcVSrXfmawYJ78 https://cassyni.com/events/78sVovFTQG5GUwpcWRvzmT/seminar/qa https://cassyni.com/slides/outline/78sVovFTQG5GUwpcWRvzmT https://cassyni.com/events/78sVovFTQG5GUwpcWRvzmT/abstract https://cassyni-user-files-prod.s3.amazonaws.com/SqeEiQXt3tsh8sGWzhtAC6 https://cassyni.com/events/78sVovFTQG5GUwpcWRvzmT?videoPreview=1 Selected N-substituted benzisoselenazol-3(2H)-ones possess anti-mycotic activity in vitro and in a mouse model of vulvovaginal candidiasisnohttps://cassyni.com/events/78sVovFTQG5GUwpcWRvzmT?videoPreview=12025-06-20T13:00:00+00:002480.04Anti-Cancer Agents in Medicinal ChemistryThe global rise of virulent and drug-resistant Candida albicans strains has intensified the need for novel antifungal agents, especially as fluconazole (FLU) resistance increases in susceptible populations. Ebselen (EB), an organoselenium compound, has emerged as a promising candidate due to its inhibition of the fungal plasma membrane H⁺-ATPase (Pma1p), a target not addressed by current antifungals. However, EB’s poor solubility and off-target effects in mammalian systems limit its therapeutic potential. To overcome these challenges, our studies pursued two parallel strategies: the development of EB nanoformulations and the synthesis of novel EB analogs. EB-loaded self-nanoemulsifying preconcentrate (EB-SNEP) demonstrated potent antifungal activity in a murine vulvovaginal candidiasis (VVC) model, significantly reducing fungal burden (~800-fold) without signs of toxicity in host tissues or probiotic flora. Concurrently, libraries of EB analogs, including G- and CHB-series compounds, were screened in vitro for activity against both FLU-sensitive and -resistant C. albicans strains. Compounds such as G20 and CHB6 showed superior efficacy (MIC as low as 3.1 µM) and targeted Pma1p-dependent acidification mechanisms. Although some analogs displayed slightly reduced growth inhibition relative to EB, they may offer better host tolerability by minimizing non-specific interactions. Taken together, our findings support organoselenium-based inhibitors as a compelling class of antifungal agents. Both EB nanoformulations and selected analogs warrant further development as treatments for FLU-resistant candidiasis, with the dual benefits of novel target specificity and improved delivery profiles. https://cassyni-user-files-prod.s3.amazonaws.com/SqeEiQXt3tsh8sGWzhtAC6 https://cassyni.com/events/BahwE55BMP4WwbaQR5hZuw/abstract https://cassyni-user-files-prod.s3.amazonaws.com/33sr3o4MY8YydD4qZaby4r https://cassyni.com/slides/outline/97mmFaWJb4V2BumG1e7o8q https://cassyni.com/events/97mmFaWJb4V2BumG1e7o8q/abstract https://cassyni-user-files-prod.s3.amazonaws.com/P9gDJd3G3fogSwqVcLk5rn https://cassyni.com/events/97mmFaWJb4V2BumG1e7o8q?videoPreview=1 Sovereignty and Cyberspace: Institutions and Internet Governancenohttps://cassyni.com/events/97mmFaWJb4V2BumG1e7o8q?videoPreview=12018-10-03T11:00:00+00:003897.16 School of Public PolicyCyberspace is one of the most critical resource domains in contemporary society. The principle of state sovereignty is one of the most important concepts underpinning the world’s governance institutions. This lecture will examine the relationship between the two. Based on an analysis of the techno-economic features of the domain, it questions the desirability and practicality of sovereignty in cyberspace, and explores the applicability of global commons models to cyberspace. While I will show that self-governance by a transnational Internet community is both possible and in many respects already exists, the military significance of the cyber domain and the mounting tensions between national authority over information and communications and the globalized capabilities of the Internet means that governance in cyberspace must take state power into account. But does this mean we are doomed to revert to the territorially fragmented governance of a sovereignty-based model? Or can some way be found to reconcile the two?https://cassyni-user-files-prod.s3.amazonaws.com/P9gDJd3G3fogSwqVcLk5rn https://cassyni.com/slides/outline/RuqvwT22uzErh23793zsHF https://cassyni.com/events/RuqvwT22uzErh23793zsHF/abstract https://cassyni-user-files-prod.s3.amazonaws.com/UK8r47qiNUsebyTi2n8i1L https://cassyni.com/events/RuqvwT22uzErh23793zsHF?videoPreview=1 Statistical mechanics lessons for data-driven methodsnohttps://cassyni.com/events/RuqvwT22uzErh23793zsHF?videoPreview=12024-10-25T19:00:00+00:003927.0AI Institute in Dynamic SystemsData-driven methods are rapidly displacing the traditional numerical schemes across many applications from fluid dynamics to biochemical reaction networks to atmospheric chemistry. The methods work well if the parameters of the dataset and the hyperparameters of the algorithm are adjusted "just so" and the minimum of a well-chosen loss function is reliably reached. However, if the data is too noisy or the regularization is chosen incorrectly, the methods would often confidently choose a nonsense solution without prior warning. In this talk I use techniques from statistical mechanics to analyze the performance and failure of two popular data-driven methods. First, system identification attempts to reconstruct a sparse differential equation from noisy observations of trajectory data but requires a lot of trial-and-error parameter tuning. By using a Bayesian inference framework with a sparsifying prior, I provide an uncertainty quantification of the identified model and the detailed anatomy of its sparsity and noise induced failure. Second, sparse sensing uses a training data set of images to allow reconstructing a new image from just a few pixel-sized sensors. I show that the reconstruction quality is highly sensitive to the sensor locations, which are explained by an effective energy landscape, and becomes highly unstable when the number of sensors matches the model dimension.https://cassyni-user-files-prod.s3.amazonaws.com/UK8r47qiNUsebyTi2n8i1L https://cassyni.com/slides/outline/H2CgDmtUR7CQejZV22eGaq https://cassyni.com/events/H2CgDmtUR7CQejZV22eGaq/abstract https://cassyni-user-files-prod.s3.amazonaws.com/51JfRAiCb3zghL7rqnrwrv https://cassyni.com/events/H2CgDmtUR7CQejZV22eGaq?videoPreview=1 Conservation imperatives for biodiversity protectionnohttps://cassyni.com/events/H2CgDmtUR7CQejZV22eGaq?videoPreview=12024-11-14T15:00:00+00:005168.88Frontiers in ScienceIn this Frontiers Forum Deep Dive session on 14 November 2024, Dr Eric Dinerstein explored next steps in the habitat conservation of rare and threatened species as part of a larger global biodiversity strategy to counteract the ongoing sixth mass extinction driven by human activities. He was joined for a panel discussion and audience question and answer session by Andy Lee, Dr Neil Aldrin Mallari, and Dr Stephen Woodley. The session brought together the authors of the Frontiers in Science lead article ‘Conservation Imperatives: securing the last unprotected terrestrial sites’. https://cassyni-user-files-prod.s3.amazonaws.com/51JfRAiCb3zghL7rqnrwrv https://cassyni.com/slides/outline/KVShTC86cPxu1g33ZiYuJm https://cassyni.com/events/KVShTC86cPxu1g33ZiYuJm/abstract https://cassyni-user-files-prod.s3.amazonaws.com/SSLALdtxqV1kumHHWUQ4Hk https://cassyni.com/events/KVShTC86cPxu1g33ZiYuJm?videoPreview=1 Photoreceptor and photosynthetic regulation of stomatal developmentnohttps://cassyni.com/events/KVShTC86cPxu1g33ZiYuJm?videoPreview=12024-10-22T13:00:00+00:001805.44The New Phytologist FoundationOur work is focused on understanding the signalling mechanisms that mediate plant developmental changes in response to environmental signals. Stomata, the microscopic pores on the leaf surface, are an excellent model for examining how environmental signals modulate plant development. Factors such as light quantity and quality as well as atmospheric carbon dioxide have a major impact on stomatal development. Using a combination of genetic and molecular tools our work has demonstrated that plant photoreceptors, significantly phyB, play a critical role in regulating stomatal development in response to environmental signals. However, photoreceptor signalling is insufficient to explain some light responses and here, photosynthetic regulation plays a major role. This pathway targets key stomatal regulators and in combination with photoreceptor control, allows for fine tuning of stomatal development under different conditions.https://cassyni-user-files-prod.s3.amazonaws.com/SSLALdtxqV1kumHHWUQ4Hk https://cassyni.com/events/PvwfVnmBjBq6ykWcg1Cjgh/abstract https://cassyni-user-files-prod.s3.amazonaws.com/FD6CLsxk3zPAFoMo647LrS https://cassyni.com/slides/outline/SQXA6mBSkoigWV2cwA7qTT https://cassyni.com/events/SQXA6mBSkoigWV2cwA7qTT/abstract https://cassyni-user-files-prod.s3.amazonaws.com/8RpPujTcpW7dy5bqNZv5fC https://cassyni.com/events/SQXA6mBSkoigWV2cwA7qTT?videoPreview=1 Does earnings capacity or other factors predict self-employment across races as well as within and between states?nohttps://cassyni.com/events/SQXA6mBSkoigWV2cwA7qTT?videoPreview=12024-11-20T21:00:00+00:00528.52Center for Black Entrepreneurship, Spelman CollegeThe demand for innovation remains constant, but Black entrepreneurs often face barriers in accessing financial capital, limiting their ability to supply innovation despite having the necessary training and product demand. Homeownership equity has been identified as a potential collateral source for business ventures; however, persistent racial wealth and income disparities, which vary across states, create additional challenges. Black entrepreneurs remain underrepresented in external financing due to factors such as lower business revenue, fear of loan applications, and systemic discrimination. Using data from the Black Wealth Data Center, the Small Business Association, and the Survey of Income and Program Participation, this study evaluates self-employment trends among Black and White individuals based on wage, race, state, and residence-based person weight to examine the financial determinants of Black entrepreneurship and the impact of location on business success. The specific aim of this research is to analyze whether Black individuals are more financially inclined to start and sustain businesses when relocation is an option versus when it is not. Preliminary findings suggest that while homeownership equity may not be the most effective financial resource in all states, self-employment income and external loans provide viable alternatives. Additionally, states with large metropolitan Black populations tend to offer greater financial support for Black entrepreneurs. When relocation is not an option, homeownership equity may serve as a more practical financial strategy. These insights contribute to a broader understanding of how geographic and financial factors shape Black entrepreneurial success.https://cassyni-user-files-prod.s3.amazonaws.com/8RpPujTcpW7dy5bqNZv5fC https://cassyni.com/events/FYFs5iwu6jXkE1aNAbxrhs/seminar/qa https://cassyni.com/slides/outline/FYFs5iwu6jXkE1aNAbxrhs https://cassyni.com/events/FYFs5iwu6jXkE1aNAbxrhs/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Y9dnhFDSsDxgNkzknfkYWz https://cassyni.com/events/FYFs5iwu6jXkE1aNAbxrhs?videoPreview=1 Spin orbit resonance cascade via core shell model: application to Mercury and Ganymede, Forced Periodic Motion by Solar Radiation Pressure in the Polyhedral Gravity Modelnohttps://cassyni.com/events/FYFs5iwu6jXkE1aNAbxrhs?videoPreview=12025-01-31T14:00:00+00:004665.04Celestial Mechanics and Dynamical AstronomyA model describing the spin orbit resonance cascade will be presented. A two-layer (core–shell) structure of the body is assumed. Two sources of dissipation are assumed: a viscous one, depending on the relative angular velocity between core and shell and a tidal one, smaller than the first, due to the viscoelastic structure of the core. It will be shown how these two sources of dissipation are needed for the capture in spin–orbit resonance. The shell and the core fall in resonance with different time scales if the viscous coupling between them is big enough. Finally, the tidal dissipation of the viscoelastic core, decreasing the eccentricity, brings the system out of the resonance in a third very long time scale. This mechanism of entry and exit from resonance ends in the 1 : 1 stable state. The exploration of small bodies in our solar system is of great interest for the planetary science community due to their high scientific value. However, their generally weak and irregular gravity fields increase the difficulty associated with close proximity operations. Moreover, solar radiation pressure (SRP) can signifi- cantly perturb the motion of objects in their vicinity, particularly for bodies with high area-to-mass ratios. In this work, we adopt the polyhedral gravity model and identify natural dynamical structures that can be used for mission operations. Further, we study forced periodic motion in the body fixed frame while account- ing for the effect of SRP with eclipses. Overall, our work seeks to identify suitable orbits and locations in the vicinity of small bodies that can be exploited for the design of science orbits. To obtain periodic orbits in the model accounting for SRP perturbations, we use a Melnikov function to find orbits that satisfy reso- nances with the asteroid spin and show no net change in energy over the orbit. We then use a differential correction scheme to find numerical solutions in the time- periodic model. Our test cases are potentially hazardous asteroid 101955 Bennu and main belt asteroid 16 Psyche.https://cassyni-user-files-prod.s3.amazonaws.com/Y9dnhFDSsDxgNkzknfkYWz https://cassyni.com/events/Nx1YtcAf5xmJs4oER3m2kV/seminar/qa https://cassyni.com/slides/outline/Nx1YtcAf5xmJs4oER3m2kV https://cassyni.com/events/Nx1YtcAf5xmJs4oER3m2kV/abstract https://cassyni-user-files-prod.s3.amazonaws.com/RfVuqyNHMYYJv1qVBxc9wU https://cassyni.com/events/Vs61YBE1ENX6MsnonVKxuB/seminar/qa https://cassyni.com/slides/outline/Vs61YBE1ENX6MsnonVKxuB https://cassyni.com/events/Vs61YBE1ENX6MsnonVKxuB/abstract https://cassyni-user-files-prod.s3.amazonaws.com/9HQKYPQSgWBhvm2UKJE6na https://cassyni.com/events/Vs61YBE1ENX6MsnonVKxuB?videoPreview=1 ExaGRyPE: Numerical general relativity solvers based upon the hyperbolic PDEs solver engine ExaHyPEnohttps://cassyni.com/events/Vs61YBE1ENX6MsnonVKxuB?videoPreview=12025-04-22T13:00:00+00:003389.24Computer Physics CommunicationsExaGRyPE is a suite of solvers for numerical relativity based on ExaHyPE 2, our second-generation Exascale Hyperbolic PDE Engine. This solver tackles the Einstein equations in the CCZ4 formulation under a 3+1 foliation, with a focus on black hole spacetimes. The implementation utilizes a block-structured Cartesian grid with higher-order Finite Difference schemes and adaptive mesh refinement while enabling massive parallelism through message passing, domain decomposition, and task parallelism. Our approach formalizes simulation creation as a sequence of lowering operations, where abstract logical tasks are broken down into progressively finer tasks until reaching a C++ executable level. The program logic is specified through a domain-specific Python interface, which maps to numerical tasks, then to technical tasks for parallelization, and finally to task graphs containing PDE evaluations, initial conditions, and boundary conditions. This architecture creates a rigorous separation of concerns, shielding users from technical details and simplifying the development of novel physical models. We present simulations of various benchmarks, demonstrating the maturity and usability of the codebase while acknowledging domain-specific numerical challenges that warrant further investigation.https://cassyni-user-files-prod.s3.amazonaws.com/9HQKYPQSgWBhvm2UKJE6na https://cassyni.com/slides/outline/2hRmzae96C4cAGGHoUwWDK https://cassyni.com/events/2hRmzae96C4cAGGHoUwWDK/abstract https://cassyni-user-files-prod.s3.amazonaws.com/9Yejt4AJJMV4PfsWh5dGwg https://cassyni.com/events/2hRmzae96C4cAGGHoUwWDK?videoPreview=1 An artificial viscosity approach to high order entropy stable DG methodsnohttps://cassyni.com/events/2hRmzae96C4cAGGHoUwWDK?videoPreview=12024-12-06T17:00:00+00:001863.24JKW Symposium TeamEntropy stable discontinuous Galerkin (DG) methods improve the robustness of high order DG simulations of nonlinear conservation laws. These methods yield a semi-discrete entropy inequality, and rely on an algebraic flux differencing formulation which involves both summation-by-parts (SBP) discretization matrices and entropy conservative two-point finite volume fluxes. However, explicit expressions for such two-point finite volume fluxes may not be available for all systems, or may be computationally expensive to compute. We propose an alternative approach to constructing entropy stable DG methods using an artificial viscosity coefficient based on the local violation of a cell entropy inequality and a local entropy dissipation estimate. The resulting method yields the same global semi-discrete entropy inequality satisfied by entropy stable flux differencing DG methods. The artificial viscosity coefficients are parameter-free and locally computable over each cell. The resulting artificial viscosity preserves high order accuracy, improves linear stability, and does not result in a more restrictive maximum stable time-step size under explicit time-stepping. https://cassyni-user-files-prod.s3.amazonaws.com/9Yejt4AJJMV4PfsWh5dGwg https://cassyni.com/events/Kz9Yj8oPraNVeqVBZVW3Ps/abstract https://cassyni-user-files-prod.s3.amazonaws.com/2QvJgoeoq3PMKF731ijjzn https://cassyni.com/events/B6Uftq9wxLQKU5KA9uD14q/abstract https://cassyni-user-files-prod.s3.amazonaws.com/WCj6KgdN74b2FVETwM1Qnr https://cassyni.com/slides/outline/J18npxV14LGCmRGsGz5yX3 https://cassyni.com/events/J18npxV14LGCmRGsGz5yX3/abstract https://cassyni-user-files-prod.s3.amazonaws.com/UmP7QJxZVZ8BTD78CaKnWz https://cassyni.com/events/J18npxV14LGCmRGsGz5yX3?videoPreview=1 Insertion of Quinoid Carbene: Applications in Heterobiaryls to Extended Conjugated Systemsnohttps://cassyni.com/events/J18npxV14LGCmRGsGz5yX3?videoPreview=12024-11-08T13:00:00+00:003018.4Thieme India ChemTalksThe diazo quinone or quinone diazide compounds have been extensively utilized to introduce phenol/naphthol moieties into hydrocarbons or nitrogen-containing heterocycles under transition metal catalysis [1]. The reactions proceed via C–H/X-H insertion or migratory insertion of metal carbenes. In this presentation, the racemic synthesis of important ligand like 8-azaBINOL and phosphine ligands like QUINAP, METHOX, PINAP, PHENAP will be discussed [2,3]. Construction of indolocoumarin, especially isolamellarins, using the migratory insertion of quinoid carbene will be explained [4]. A straightforward Rh(III)-catalyzed method for the introduction of naphthol/phenol moieties to the C(sp3)–H bond of 8-methylquinoline using diazonaphthalen-2(1H)-ones/quinone diazides will be explained [5]. Further, site-selective N-arylation of benzotriazole, 2-hydroxy pyridine and amide bonds using quinoid carbene via insertion and migratory insertion methods will be explored [6-8]. Next, a Ru(II)-catalyzed method to construct O-alkylated arylnaphthyl thioether derivatives using α-thioesters and diazonaphthoquinone via an unprecedented [1,4]-oxa sigmatropic rearrangement and in a complementary method, O-heteroaryl alkylnaphthyl thioether derivatives via a a concerted intramolecular SNAr-type reaction will be explained [9]. https://cassyni-user-files-prod.s3.amazonaws.com/UmP7QJxZVZ8BTD78CaKnWz https://cassyni.com/events/97TuzeqZA6J2af6qsPnwC1/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Gvq3WY9HPyftrJa1nCKZqY https://cassyni.com/slides/outline/7dYiyEQsF5Z6JQp8JY3xwf https://cassyni.com/events/7dYiyEQsF5Z6JQp8JY3xwf/abstract https://cassyni-user-files-prod.s3.amazonaws.com/KmFKkhdjoHE7UYwcuBweK8 https://cassyni.com/events/7dYiyEQsF5Z6JQp8JY3xwf?videoPreview=1 Preserving microbial diversity: An Australian perspectivenohttps://cassyni.com/events/7dYiyEQsF5Z6JQp8JY3xwf?videoPreview=12025-09-11T03:00:00+00:00654.08Microbiome Virtual International ForumPreserving human microbiome diversity can be approached from different angles: 1) preserving microbial species, 2) preserving information (i.e., the metagenomes and metadata associated with it), and 3) helping future generations maintain a healthy, diverse microbiome. In this presentation, we will discuss some of the key elements and challenges of each. https://cassyni-user-files-prod.s3.amazonaws.com/KmFKkhdjoHE7UYwcuBweK8 https://cassyni.com/events/F3GnfV7jpwrvnzLbGQuhMf/seminar/qa https://cassyni.com/slides/outline/F3GnfV7jpwrvnzLbGQuhMf https://cassyni.com/events/F3GnfV7jpwrvnzLbGQuhMf/abstract https://cassyni-user-files-prod.s3.amazonaws.com/7YgFNkBCJekLnuz6xV978J https://cassyni.com/events/F3GnfV7jpwrvnzLbGQuhMf?videoPreview=1 Intrinsic Random Function Kriging on the Spherenohttps://cassyni.com/events/F3GnfV7jpwrvnzLbGQuhMf?videoPreview=12025-08-13T15:00:00+00:003231.48Journal of Statistical Theory and PracticeIntrinsic random functions (IRFs) can be used to model spatial processes on the sphere. To perform kriging using IRFs, one needs the knowledge of the IRF order (i.e., the degree of non-homogeneity) and its associate generalized covariance function, which are challenging in Euclidean spaces and hinder its practice. On the sphere, Huang et al. (2019) showed that IRFs behave differently from their counterparts in Euclidean spaces and can be characterized by their lower-frequency truncated processes. Based on this, we develop procedures to estimate both the IRF order and the associated parametric generalized covariance function. Then, a truly IRF-based universal kriging can be implemented in practice on the sphere. We demonstrate our methods through simulations, and the numerical results show that IRF kriging outperforms ordinary kriging. Additionally, we apply our procedure to a global temperature dataset to determine the IRF order.https://cassyni-user-files-prod.s3.amazonaws.com/7YgFNkBCJekLnuz6xV978J https://cassyni.com/slides/outline/EYdBcoUDPVJsoDohfycu6M https://cassyni.com/events/EYdBcoUDPVJsoDohfycu6M/abstract https://cassyni-user-files-prod.s3.amazonaws.com/6Fmu5XGmLHoraWBoYcrrJi https://cassyni.com/events/EYdBcoUDPVJsoDohfycu6M?videoPreview=1 Strategic Insights on Information Security in Businessnohttps://cassyni.com/events/EYdBcoUDPVJsoDohfycu6M?videoPreview=12024-08-21T23:00:00+00:003129.84Business SchoolThe pervasive nature of technology in modern business necessitates strategic insights into information security to protect financial and personal data. Common cyber threats, such as phishing and ransomware, demonstrate the widespread financial and personal consequences of security breaches. Even national institutions and critical infrastructure, exemplified by incidents involving the NZX and the RBNZ in New Zealand, remain susceptible to cyber events, including those originating from third-party vulnerabilities. Addressing these challenges requires a multi-faceted approach. Non-technical roles, including Information Security Analysts, GRC (Governance, Risk, and Compliance) specialists, and Security Auditors, are crucial for mitigating risk and ensuring adherence to frameworks. Professional certifications like CISM, CRISC, and CISA, alongside relevant privacy legislation such as the New Zealand Privacy Act and GDPR, provide foundational knowledge. The emergence of artificial intelligence (AI) introduces new security considerations, with evolving governance frameworks (e.g., ISO, NIST, EU AI Act) emphasizing transparent public disclosure, human oversight, the prevention of algorithmic bias, and continuous monitoring. Effective security management relies on frameworks like ISO 27001, the NIST Cybersecurity Framework, and COBIT, underpinning a continuous risk management cycle involving identification, assessment, treatment, and monitoring. These insights highlight the critical need for continuous learning and vigilance in safeguarding information in an increasingly interconnected and AI-driven world.https://cassyni-user-files-prod.s3.amazonaws.com/6Fmu5XGmLHoraWBoYcrrJi https://cassyni.com/slides/outline/9c999xzxzumrQ86MfVuuND https://cassyni.com/events/9c999xzxzumrQ86MfVuuND/abstract https://cassyni-user-files-prod.s3.amazonaws.com/JsTLSmPz3Fu6Yja3zeTAZU https://cassyni.com/events/9c999xzxzumrQ86MfVuuND?videoPreview=1 Digital transformation: Airport ecosystem forward planning with actionable insightsnohttps://cassyni.com/events/9c999xzxzumrQ86MfVuuND?videoPreview=12021-06-08T23:00:00+00:003106.0Business SchoolThe COVID-19 pandemic caused unprecedented disruption to global travel, leading to a 73% decline in overall passenger movements and a 97% drop in the international sector at Auckland Airport. This necessitated an agile approach to operational planning and rendered traditional forecasting methods obsolete. To address these challenges, Auckland Airport's capacity optimization team implemented advanced digital technologies and data analytics. Key initiatives included the intensive use of scenario planning (BONR) and information distribution tools (Power BI), alongside a migration from a legacy on-premise system to a Microsoft Azure cloud computing solution for enhanced data management. An automated forecasting system was developed using Azure tools and data science to predict passenger numbers based on dynamic recovery information, streamlining daily planning and reducing manual analysis. Additionally, a sophisticated capacity modeling tool (BONTRA) was utilized for "what-if" scenarios, informing the design of separate international arrival pathways (Zone A for quarantine-free travel, Zone B for non-quarantine-free travel) to comply with health requirements and social distancing. This modeling also determined optimum staffing levels to minimize guest wait times and prevent potential COVID-19 spread. An end-to-end guest journey flow model further identified operational pinch points, facilitating collaborative resolution of resource allocation issues with stakeholders. This digital transformation enabled the provision of reliable, actionable insights, strengthening collaboration and supporting the safe recovery and rebuilding of the travel and tourism sector.https://cassyni-user-files-prod.s3.amazonaws.com/JsTLSmPz3Fu6Yja3zeTAZU https://cassyni.com/events/StrutXADmJ5jthKFRWUSYm/seminar/qa https://cassyni.com/slides/outline/StrutXADmJ5jthKFRWUSYm https://cassyni.com/events/StrutXADmJ5jthKFRWUSYm/abstract https://cassyni-user-files-prod.s3.amazonaws.com/6iTzY1VuLBUAhtRHFe1MyG https://cassyni.com/events/StrutXADmJ5jthKFRWUSYm?videoPreview=1 Swipe Culture & Women’s Health: Exploring Current Themes in Dating App Researchnohttps://cassyni.com/events/StrutXADmJ5jthKFRWUSYm?videoPreview=12025-10-03T14:00:00+00:002552.24Women's Health"Dating apps are revolutionizing how we approach intimacy and digital communication, which has implications for our mental and sexual health. As a researcher, writer, and activist working in the digital health and sexuality space, launching this Special Collection is a passion project that has the potential to help us radically rethink women's health and the role that swipe culture plays in our lives." - Dr Treena Orchard, Guest Editor of the Special Collectionhttps://cassyni-user-files-prod.s3.amazonaws.com/6iTzY1VuLBUAhtRHFe1MyG https://cassyni.com/slides/outline/QRctf6vba1JvoDW8U7Khru https://cassyni.com/events/QRctf6vba1JvoDW8U7Khru/abstract https://cassyni-user-files-prod.s3.amazonaws.com/CUXAyRro76rEmYMKGHqYq4 https://cassyni.com/events/QRctf6vba1JvoDW8U7Khru?videoPreview=1 Coupled wave theory: from meta-media to gravitational wavesnohttps://cassyni.com/events/QRctf6vba1JvoDW8U7Khru?videoPreview=12025-11-21T11:00:00+00:003148.44UK Metamaterials NetworkCoupled wave theory has been used since the sixties as a method to describe how light is remitted from 1-D periodic structures, such as Bragg gratings. Some recent advances have enabled this venerable technique to be applied to some artificial meta-media, resulting in some interesting, and potentially useful effects: a Bragg-like reflection from a homogeneous medium, for example. The technique has also been adapted to recently explored time-varying media showing some interesting enhancements in temporal quasi-crystals. Finally, a truly four-dimensional coupled wave theory has recently been developed describing light modulated by lossless, dispersionless undulations that travel at the speed of light, i.e. gravitational waves.https://cassyni-user-files-prod.s3.amazonaws.com/CUXAyRro76rEmYMKGHqYq4 https://cassyni.com/slides/outline/KV8rCGTMBRmuQ7nnTdci8m https://cassyni.com/events/KV8rCGTMBRmuQ7nnTdci8m/abstract https://cassyni-user-files-prod.s3.amazonaws.com/RPk2NjnVzmErFtHq7M6qPU https://cassyni.com/events/KV8rCGTMBRmuQ7nnTdci8m?videoPreview=1 Distinct exceptional points in Hermitian phononic laminatesnohttps://cassyni.com/events/KV8rCGTMBRmuQ7nnTdci8m?videoPreview=12025-06-17T05:00:00+00:001866.0ETOPIMOpen systems, described by non-Hermitian operators, can exhibit degeneracies where two or more of their eigenmodes coalesce. These degeneracies, termed exceptional points (EPs), present exotic wave phenomena and thus serve as a tool for metamaterial design. Most studies focus on temporal EPs, which form when two (or more) resonance frequencies coalesce. These works incorporate gain and loss that are often balanced to form PT symmetry for temporal stability. Here, we present a framework that eliminates the need for material gain or loss by breaking spatial Hermitian symmetry using the features that are unique to elastodynamics. We design a unit cell with two isotropic Hermitian (conservative) materials to form a second-order EP, and show it give rise to negative refraction. We extend our design and achieve the coalescence of three Bloch modes (EP3) using anisotropic material [Fig. (c)]. We show it gives rise to modes with zero axial group velocity and finite transmittance, known as ’axially frozen modes’ [3]) [Fig. (d)]. These modes, previously discovered in 3D dielectric laminates [3], are now accessible in simpler, planar settings in elastodynamics, thanks to the distinct tensorial properties of elastodynamics. We acknowledge funding by the European Union (ERC, EXCEPTIONAL, Project No. 101045494). Views and opinions expressed are however those of the authors only and do not necessarily reflect those of the EU or the European Research Council Executive Agency. Neither the European Union nor the granting authority can be held responsible for them.https://cassyni-user-files-prod.s3.amazonaws.com/RPk2NjnVzmErFtHq7M6qPU https://cassyni.com/slides/outline/XqLxMMdU9scmHo2bRzBSGu https://cassyni.com/events/XqLxMMdU9scmHo2bRzBSGu/abstract https://cassyni-user-files-prod.s3.amazonaws.com/GFkM26KHso15zq6Uc18pbQ https://cassyni.com/events/XqLxMMdU9scmHo2bRzBSGu?videoPreview=1 Quantum algorithms to realize and study fractional Hall statesnohttps://cassyni.com/events/XqLxMMdU9scmHo2bRzBSGu?videoPreview=12025-06-19T01:00:00+00:001636.2ETOPIMIntermediate-scale quantum technologies provide unprecedented opportunities for scientific discoveries while posing the challenge of identifying important problems that can take advantage of them through algorithmic innovations. Fractional Hall systems which are one class of correlated electron systems with many interesting and puzzling properties. In this talk I present an efficient quantum algorithm to generate an equivalent many-body state to Laughlin's ν=1/3 fractional quantum Hall state on a digitized quantum computer. Our algorithm only uses quantum gates acting on neighboring qubits in a quasi-one-dimensional setting, and its circuit depth is linear in the number of qubits. I then present another quantum algorithm to generate and study out of equilibrium properties of fractional Hall state. Such features reveals novel geometric aspects of fractional Hall states which mimics gravitons.https://cassyni-user-files-prod.s3.amazonaws.com/GFkM26KHso15zq6Uc18pbQ https://cassyni.com/slides/outline/SQDJqqWhKqXgtvnMq5BeHT https://cassyni.com/events/SQDJqqWhKqXgtvnMq5BeHT/abstract https://cassyni-user-files-prod.s3.amazonaws.com/EuMRWQZ43mbhhp7zydzUsQ https://cassyni.com/events/SQDJqqWhKqXgtvnMq5BeHT?videoPreview=1 Pump-induced polariton excitation and topological transitions in Van der Waals crystalsnohttps://cassyni.com/events/SQDJqqWhKqXgtvnMq5BeHT?videoPreview=12025-06-15T23:00:00+00:00701.2ETOPIMThe study addresses the challenge of exciting surface phonon polaritons—resonant infrared surface waves supported by anisotropic polar materials—without requiring irreversible patterning of the material. These hyperbolic surface polaritons, characterized by anisotropic permittivity tensors with sign-changing components, enable ultraconfined and directional light propagation but are difficult to excite due to momentum mismatch and the mid-infrared frequency range. The approach employs a nonlinear phononics pump-probe scheme, where a strong mid-infrared pump pulse displaces ions in a van der Waals crystal (specifically α-MoO3), inducing a non-thermal phonon population that modifies material properties and enables parametric amplification of a weak probe signal. A transmission matrix method coupled with nonlinear polarization dynamics and Floquet mode expansions models the system, revealing that pumping near phonon resonances facilitates down-conversion of incoming radiation into backward-propagating hyperbolic surface waves without physical gratings. Furthermore, by varying the pump polarization and intensity along different crystal axes, the resonant frequencies of polaritonic modes are linearly modulated, inducing reversible topological transitions between hyperbolic and elliptic dispersion regimes. This all-optical modulation enables dynamic control over surface wave propagation and topology in van der Waals crystals, offering a reconfigurable platform for enhanced light–matter interactions and potential applications in mid-infrared photonics without permanent structural modifications.https://cassyni-user-files-prod.s3.amazonaws.com/EuMRWQZ43mbhhp7zydzUsQ https://cassyni.com/events/2h7vjeyPfDscYi22hQ1K3K/seminar/qa https://cassyni.com/slides/outline/2h7vjeyPfDscYi22hQ1K3K https://cassyni.com/events/2h7vjeyPfDscYi22hQ1K3K/abstract https://cassyni-user-files-prod.s3.amazonaws.com/XyerqtLtuSXPzEYY7ifQNa https://cassyni.com/events/2h7vjeyPfDscYi22hQ1K3K?videoPreview=1 Managing water across the flood–drought spectrum: Experiences from and challenges for the Netherlandsnohttps://cassyni.com/events/2h7vjeyPfDscYi22hQ1K3K?videoPreview=12025-09-25T14:00:00+00:002112.48Cambridge PrismsRecent impactful hydrometeorological events, on both the extreme wet and dry side of the spectrum, remind policymakers and citizens that climate change is a reality and that a shift in water management solutions is required. A selection of policy-shaping events in the Netherlands shows that both floods and droughts have occurred historically and continue to occur, causing significant impacts and challenges for water resources management. For decades, water management in the Netherlands has focused on implementing flood prevention policies, mostly prompted by specific events. The occurrence of droughts did not lead to comparable significant transitions in water management. The bias toward adaptation measures on the wet part of the spectrum (i.e., floods), increases vulnerability to dry extremes (i.e., droughts) as experienced in 2018–2020 and 2022. A required long-term, integral vision to rethink the existing water management system is challenging as droughts and floods act on different time scales. Furthermore, there is a fierce competition for land use and water use functions. ‘Transformation pathways’, applied across the full flood–drought spectrum, could provide a valuable framework in the development toward a sustainable management of water resources, involving stakeholders for just and equitable transitions and translating long-term visions into pathways for action.https://cassyni-user-files-prod.s3.amazonaws.com/XyerqtLtuSXPzEYY7ifQNa https://cassyni.com/slides/outline/5eyvu8LetcGRkwL5YxGJPw https://cassyni.com/events/5eyvu8LetcGRkwL5YxGJPw/abstract https://cassyni-user-files-prod.s3.amazonaws.com/852in2HJgatC1cLfiV4r9L https://cassyni.com/events/5eyvu8LetcGRkwL5YxGJPw?videoPreview=1 Back to the roots: belowground biomass as a primary carbon source for soil microbesnohttps://cassyni.com/events/5eyvu8LetcGRkwL5YxGJPw?videoPreview=12025-07-09T12:00:00+00:001724.04NoneEstimating plants' belowground biomass, their growth dynamics or functional traits are increasingly prominent, and an increasingly extensive number of root traits datasets have great potential to link root functioning to soil microbiome interactions.  I aim to (1) highlight the importance of considering the functional distribution and group-specific dynamics of belowground biomass for understanding root-microbe relationships (e.g. proportional shifts between roots and rhizomes in grasslands or between absorptive and transport roots in forests); (2) revisit the methodological challenges of measuring fine root growth dynamics in the context of global change; (3) summarize recent advances in quantifying root-mediated carbon fluxes in the rhizosphere. Current estimates of fine root biomass dynamics rely on a variety of methods, from soil coring to image-based approaches (e.g. cameras and scanners), while rhizosphere carbon fluxes were measured using cuvette and microdialysis techniques, combined with metabolite profiling and microbial community analyses. Belowground biomass dynamics with proportional shifts between long-lived rhizomes and short-lived roots in grasslands, or in the functional structure of fine roots in forest trees, are part of the adaptation in a changing environment that can significantly affect soil C input and pools. Shifts in phenology can alter root senescence patterns, triggering cascading effects on microbial communities.  https://cassyni-user-files-prod.s3.amazonaws.com/852in2HJgatC1cLfiV4r9L https://cassyni.com/slides/outline/3BmXnLcv6gRfYUYvHqJ7Jd https://cassyni.com/events/3BmXnLcv6gRfYUYvHqJ7Jd/abstract https://cassyni-user-files-prod.s3.amazonaws.com/5XbbgLdYSTUDwzcFgPvmiW https://cassyni.com/events/3BmXnLcv6gRfYUYvHqJ7Jd?videoPreview=1 Learning from unstable microbiomesnohttps://cassyni.com/events/3BmXnLcv6gRfYUYvHqJ7Jd?videoPreview=12025-11-12T14:00:00+00:002167.12Microbiome Virtual International ForumMost eukaryotes harbor diverse and complex microbial communities, but we also know of many cases where the community composition and microbial load are unstable. I will give an overview of a few examples from our work on the microbiota of several insects, and rice. I will then describe the red flour beetle in more detail: its microbiome is beneficial for the host, but both the benefit and the microbial community structure vary dramatically. Across a 3-year period, the total load and composition of the bacterial community of laboratory stock populations fluctuated dramatically, cycling between a few dominant taxa and hundreds of rare taxa. Manipulative experiments suggest that this ecological drift is caused by changes in host population size and structure driven by laboratory maintenance protocols, as well as intrinsic differences in life stage-specific host-microbe interactions driven by host ecology. I suggest that such unstable microbial communities can serve as great model systems to understand the evolution and ecology of diverse host-microbial interactions.https://cassyni-user-files-prod.s3.amazonaws.com/5XbbgLdYSTUDwzcFgPvmiW https://cassyni.com/slides/outline/2CShaLoypQPnjF2WuHtLs7 https://cassyni.com/events/2CShaLoypQPnjF2WuHtLs7/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Wj5ZMe1fqXE2E47YwiXyqY https://cassyni.com/events/2CShaLoypQPnjF2WuHtLs7?videoPreview=1 MetaRORnohttps://cassyni.com/events/2CShaLoypQPnjF2WuHtLs7?videoPreview=12025-04-02T08:00:00+00:002529.76The Research on Research (RoR) TeamThere are well-known complexities and challenges in current research evaluation approaches. One of these being that traditional evaluation methods, including rankings and binary publication decisions, often fail to capture the diverse value of research. However, implementing alternative evaluation approaches at scale poses significant practical resource barriers, (e.g., cost and time). A potential solution to this challenge involves multi-dimensional assessment, evaluating publications on criteria including validity, relevance, impact, ethics, and transparency. The MetaROR and AMOS are actively collaborating with RoRI partners, publishers, and meta science researchers to address these evaluation challenges through a platform that embeds the "publish, review, curate" model. The model offers better support towards knowledge creation by adopting a multi-dimensional approach to evaluation. The central message of the webinar looked at how MetaROR can offer an alternative for research evaluation while crucially remaining practical and applicable for use in contexts where large-scale evaluation is needed, including funding allocation, recruitment, and promotion. For more information on MetaROR and to contact the team, please visit <https://cms.metaror.org/>.https://cassyni-user-files-prod.s3.amazonaws.com/Wj5ZMe1fqXE2E47YwiXyqY https://cassyni.com/slides/outline/DZPDkhCwKJ464yr4JwEzz9 https://cassyni.com/events/DZPDkhCwKJ464yr4JwEzz9/abstract https://cassyni-user-files-prod.s3.amazonaws.com/E1QHLPXyKCKzZMtCN4JRqg https://cassyni.com/events/DZPDkhCwKJ464yr4JwEzz9?videoPreview=1 The ecology and evolution of small bacterial communitiesnohttps://cassyni.com/events/DZPDkhCwKJ464yr4JwEzz9?videoPreview=12026-01-20T14:00:00+00:002268.24Microbiome Virtual International ForumUnderstanding how microbial communities in natural ecosystems assemble and evolve is crucial, as these communities greatly affect us and our environment. But since studying eco-evolutionary dynamics in natural systems is extremely challenging, in my lab we use small bacterial communities as model systems. I will give an overview of the work in our lab. I will first talk about how four species of bacteria interact to degrade pollutants in industrial waste waters, how these interactions are shaped by the environment over short and evolutionary timescales, and how we can use the principles of group selection to breed new communities from scratch for more efficient bioremediation. I will then present more recent work that generalises on these findings to see whether we can predict and control ecological and evolutionary dynamics in other contexts as well.https://cassyni-user-files-prod.s3.amazonaws.com/E1QHLPXyKCKzZMtCN4JRqg https://cassyni.com/events/A6qzRugGF6BT3HYVfGs3TK/seminar/qa https://cassyni.com/slides/outline/A6qzRugGF6BT3HYVfGs3TK https://cassyni.com/events/A6qzRugGF6BT3HYVfGs3TK/abstract https://cassyni-user-files-prod.s3.amazonaws.com/6n6w2XmK3cPspRkNta6q2n https://cassyni.com/events/A6qzRugGF6BT3HYVfGs3TK?videoPreview=1 Exploring early life microbiome dynamicsnohttps://cassyni.com/events/A6qzRugGF6BT3HYVfGs3TK?videoPreview=12026-03-24T13:00:00+00:001936.4Microbiome Virtual International ForumEarly life represents a critical window for microbiome establishment, with long-lasting implications for immune development, metabolic function, and susceptibility to infection. In this talk, I will explore how microbial interventions, such as probiotics, can support healthy microbiome development in vulnerable infant populations. I will discuss emerging evidence on how beneficial microbes and their metabolites influence host-microbe interactions, shape microbial ecology, and potentially reduce the burden of antimicrobial resistance. Finally, I will consider how a deeper mechanistic understanding of early microbial colonisation can inform the design of targeted, precision-based strategies to promote optimal health trajectories from the very beginning of life.https://cassyni-user-files-prod.s3.amazonaws.com/6n6w2XmK3cPspRkNta6q2n https://cassyni.com/events/E2tJ7Zj8ExdSPBgBKaxV7B/seminar/qa https://cassyni.com/events/E2tJ7Zj8ExdSPBgBKaxV7B/abstract https://cassyni-user-files-prod.s3.amazonaws.com/FRa8By1AJVsjdmCgEio6u4 https://cassyni.com/events/E2tJ7Zj8ExdSPBgBKaxV7B?videoPreview=1 RAMP Community Call #1nohttps://cassyni.com/events/E2tJ7Zj8ExdSPBgBKaxV7B?videoPreview=12025-08-18T16:00:00+00:001769.24Research Evaluation and Analytics Capacity HubLearn more about the Research Analytics Mentorship Program (RAMP), a signature program of the REACH Network. This peer-to-peer mentorship program aims to work with participants to grow and expand knowledge within areas related to research analytics, responsible evaluation, data-driven decision making and use of data within the field of research management. This community call will introduce participants to the RAMP program and answer any questions you might have. This is the first of two identical informational sessions about this program. The next session will be held on 8/26.https://cassyni-user-files-prod.s3.amazonaws.com/FRa8By1AJVsjdmCgEio6u4 https://cassyni.com/slides/outline/GW8KLyxkSFPvk89jsGs7q7 https://cassyni.com/events/GW8KLyxkSFPvk89jsGs7q7/abstract https://cassyni-user-files-prod.s3.amazonaws.com/GPfS1oj1wREbXoJrVyXMQi https://cassyni.com/events/GW8KLyxkSFPvk89jsGs7q7?videoPreview=1 Discussion on Guiding Principles For Sound Energy Policynohttps://cassyni.com/events/GW8KLyxkSFPvk89jsGs7q7?videoPreview=12021-02-11T09:00:00+00:004336.76 School of Public PolicyThis seminar explores foundational principles for sound energy policy amid the urgent challenges of climate change and energy system transformation. The discussion emphasizes the necessity of bipartisan, consensus-driven approaches that balance multiple energy attributes—affordability, reliability, diversity, security, and environmental impact—without sacrificing one for another. Key guiding principles include adherence to science-based targets for net-zero emissions by mid-century, promotion of a just and equitable transition addressing historically underserved communities and workers affected by energy shifts, and the integration of climate adaptation and resilience into infrastructure planning. The importance of polycentric governance is highlighted, advocating coordinated action across federal, state, and local levels to optimize policy ecosystems tailored to regional contexts. Inclusiveness emerges as a critical principle, ensuring diverse stakeholder engagement to enhance policy quality, fairness, and political viability. The dialogue underscores that energy and climate policies are deeply interconnected, requiring integrated strategies that encompass housing, transportation, and economic development. Investment in research, development, and deployment of emerging technologies is identified as essential for achieving decarbonization goals while fostering economic growth and job creation. The discussion also critiques traditional notions such as energy independence, reframing them as risk management and supply chain security concerns. Finally, equity considerations call for intentional design of policies to avoid regressive impacts, with mechanisms like offsets and subsidies to support vulnerable populations. The seminar concludes that establishing widely accepted principles can facilitate more productive policy development and implementation in a politically divided environment.https://cassyni-user-files-prod.s3.amazonaws.com/GPfS1oj1wREbXoJrVyXMQi https://cassyni.com/slides/outline/96QFejFsrP6Qz5xqK7FVP3 https://cassyni.com/events/96QFejFsrP6Qz5xqK7FVP3/abstract https://cassyni-user-files-prod.s3.amazonaws.com/2pfnuZpwGyw7zygwP4BM2N https://cassyni.com/events/96QFejFsrP6Qz5xqK7FVP3?videoPreview=1 Biophysical models of the non-pregnant uterus to predict contractile dysfunctionnohttps://cassyni.com/events/96QFejFsrP6Qz5xqK7FVP3?videoPreview=12025-10-07T23:00:00+00:003555.4Auckland Bioengineering InstituteWhile the role of uterine contractions is well known in labour to ensure successful delivery of the fetus, the mechanisms driving coordinated uterine contractions are less clear. Outside of pregnancy the structural and contractile properties of the uterus relate to fertility issues, and conditions such as endometriosis. I will present data driven computational models that aim to describe the anatomy and function of the uterus in both preclinical animal models and using data that can be acquired clinically in humans. I will describe the key components that we include in multi-scale computational models of uterine function, and strategies that we have followed to combine data from multiple sources to better understand physiology. I will contextualise this research around wider efforts within the 12 Labours Project in which we seek to integrate data from wearables and clinical measurements to understand the human body.https://cassyni-user-files-prod.s3.amazonaws.com/2pfnuZpwGyw7zygwP4BM2N https://cassyni.com/slides/outline/BZeGt9VW3fruM2SProA86y https://cassyni.com/events/BZeGt9VW3fruM2SProA86y/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Nn5X4bF578ghbzVi85VbCS https://cassyni.com/events/BZeGt9VW3fruM2SProA86y?videoPreview=1 Learning to LEED: Ecolabels, Innovation, and Green Market Transformationnohttps://cassyni.com/events/BZeGt9VW3fruM2SProA86y?videoPreview=12024-01-18T09:00:00+00:003602.28 School of Public PolicyDelivered at the Brook Byers Institute for Sustainable Systems, Georgia Institute of Technology, on January 18th, 2024https://cassyni-user-files-prod.s3.amazonaws.com/Nn5X4bF578ghbzVi85VbCS https://cassyni.com/slides/outline/Put19sBWRUdVPBNc7ifHsj https://cassyni.com/events/Put19sBWRUdVPBNc7ifHsj/abstract https://cassyni-user-files-prod.s3.amazonaws.com/54EKWUeaDtjiTXaKpfGDNN https://cassyni.com/events/Put19sBWRUdVPBNc7ifHsj?videoPreview=1 Tracking performance at the education program objective level: Sounds good in theory, but does it work in practice?nohttps://cassyni.com/events/Put19sBWRUdVPBNc7ifHsj?videoPreview=12024-03-20T09:00:00+00:002874.72AAMCMedical schools must evaluate if students achieve education program objective (EPO) and address suboptimal EPO performance. Thus, assessment performance must be tracked at the EPO level. Each EPO is measured with different assessment types and outcomes (narrative, %, points) so aggregating EPO performance is difficult. In this session we will share one medical school's process for going from "unsatisfactory" to "satisfactory" for LCME element 8.4 specific to aggregating outcomes to ensure students achieve all EPOs. Additionally, we will share tips for sustainability that go beyond accreditation compliance. This webinar is part of the Building Better Curriculum Series, hosted by the AAMC. For more information on the complete series, see the [series webpage](https://www.aamc.org/about-us/mission-areas/medical-education/curriculum-resources/establish-your-ci/webinars).  https://cassyni-user-files-prod.s3.amazonaws.com/54EKWUeaDtjiTXaKpfGDNN https://cassyni.com/events/JUkMeM4jbSYQzK8NWofVtH/abstract https://cassyni-user-files-prod.s3.amazonaws.com/ESwoXob9GyYDSeqTJm8pJr https://cassyni.com/events/JUkMeM4jbSYQzK8NWofVtH?videoPreview=1 Text to Trends: Unlocking New Innovation Indicators with NLP and Text Miningnohttps://cassyni.com/events/JUkMeM4jbSYQzK8NWofVtH?videoPreview=12024-06-18T08:00:00+00:003993.64 School of Public PolicyAbstract not yet added.https://cassyni-user-files-prod.s3.amazonaws.com/ESwoXob9GyYDSeqTJm8pJr https://cassyni.com/events/SP9eVuw228L5JfECEdFXhf/seminar/qa https://cassyni.com/slides/outline/SP9eVuw228L5JfECEdFXhf https://cassyni.com/events/SP9eVuw228L5JfECEdFXhf/abstract https://cassyni-user-files-prod.s3.amazonaws.com/H6Jb1XZN1zYudZX5c44yUS https://cassyni.com/events/SP9eVuw228L5JfECEdFXhf?videoPreview=1 Designing and implementing Christian-based addiction recovery programming using community-engaged methodsnohttps://cassyni.com/events/SP9eVuw228L5JfECEdFXhf?videoPreview=12025-11-13T21:00:00+00:003207.28Family MedicineAt the end of this talk, participants will be able to: * Understand the role of Christian clergy in designing and implementing addiction recovery programming using community-engaged methods. * Explain how Christian clergy’s recommendations for recovery program components have been integrated into the design of a pilot Christian based recovery support program in collaboration with two RI churches affiliated with the Ministers Alliance of RI. * Describe how Christian-based recovery support approaches can integrate with implementation science to study addiction recovery programming for public health and primary care settings.https://cassyni-user-files-prod.s3.amazonaws.com/H6Jb1XZN1zYudZX5c44yUS https://cassyni.com/events/SsoFYbaYTat8JRm5q4YKxy/seminar/qa https://cassyni.com/slides/outline/SsoFYbaYTat8JRm5q4YKxy https://cassyni.com/events/SsoFYbaYTat8JRm5q4YKxy/abstract https://cassyni-user-files-prod.s3.amazonaws.com/3DDroLCzaxQyfAkk2PL5yg https://cassyni.com/slides/outline/5dvGZCkyau4pAfmuxWLBp9 https://cassyni.com/events/5dvGZCkyau4pAfmuxWLBp9/abstract https://cassyni-user-files-prod.s3.amazonaws.com/8s8xJ5Z7VpQKPSS2A7fy1G https://cassyni.com/events/5dvGZCkyau4pAfmuxWLBp9?videoPreview=1 Baking Resilience into the Food Systemnohttps://cassyni.com/events/5dvGZCkyau4pAfmuxWLBp9?videoPreview=12021-03-24T06:00:00+00:003360.84Part of the nonprofit Annual Reviews organizationEmpty grocery stores shelves. Shuttered restaurants. Milk spoiled and dumped. The pandemic served as an unscheduled stress test for the world’s food systems, highlighting gaps, weak points, and strengths. How did food supply chains fare in different regions? What safety nets exist for those at risk of food insecurity? What are the benefits and drawbacks of local food-based systems versus global supply chains? How might other circumstances like drought or diminished crop yields affect how the population grows and consumes food? And, going forward, what can people and institutions do — from farmers to processors to governments — to build more resilient food supply chains in the face of climate change and future pandemics?https://cassyni-user-files-prod.s3.amazonaws.com/8s8xJ5Z7VpQKPSS2A7fy1G https://cassyni.com/slides/outline/VM1efPJHFWitWaxQ8LuBq7 https://cassyni.com/events/VM1efPJHFWitWaxQ8LuBq7/abstract https://cassyni-user-files-prod.s3.amazonaws.com/4xnGB7FbWZN9kWo4SKrJEa https://cassyni.com/events/VM1efPJHFWitWaxQ8LuBq7?videoPreview=1 Intellectual Property Issues Panelnohttps://cassyni.com/events/VM1efPJHFWitWaxQ8LuBq7?videoPreview=12016-03-04T09:00:00+00:005383.76 School of Public PolicyThis panel addresses the complex intellectual property (IP) challenges emerging from advances in 3D printing and digital modeling technologies, particularly as they intersect with cultural artifacts, medical applications, virtual models, and patent law. The discussion highlights how public domain cultural works, such as ancient bronzes, face “hyper ownership” through physical control, contractual restrictions, and attempts to assert copyright over reproductions, despite lacking legal basis for such protection. The transformative potential of 3D printing is emphasized as a democratizing force that shifts these works from tangible objects to informational assets, raising questions about access and cultural repatriation. In medical contexts, 3D printing facilitates surgical planning and patient-specific devices, yet reimbursement and IP enforcement remain significant hurdles, especially regarding copyrights in digitized medical images and patent rights in functional printed devices. The panel further explores virtual models and digital files, underscoring the limited copyright protection for exact digital replicas absent original creative input, as illustrated by the Meshworks case, and the evolving interplay of copyright, design patents, and rights of publicity in 3D-printed fashion and virtual representations. Patent exhaustion doctrine is examined through the Lexmark case, revealing that restrictions on use can be enforceable and that international sales do not exhaust U.S. patent rights, with implications for additive manufacturing’s spare parts market. The panel concludes that IP protection in additive manufacturing spans multiple rights—utility, design, copyright, trademark—and that future legal and business models must adapt to the dispersed, decentralized production enabled by these technologies, balancing innovation incentives with access and enforcement challenges.https://cassyni-user-files-prod.s3.amazonaws.com/4xnGB7FbWZN9kWo4SKrJEa https://cassyni.com/slides/outline/4ed4TqTvhyxfVuwurXrs1F https://cassyni.com/events/4ed4TqTvhyxfVuwurXrs1F/abstract https://cassyni-user-files-prod.s3.amazonaws.com/7RCyPMiMBRSJEF74Cy391G https://cassyni.com/events/4ed4TqTvhyxfVuwurXrs1F?videoPreview=1 Fluids outreach and Engagementnohttps://cassyni.com/events/4ed4TqTvhyxfVuwurXrs1F?videoPreview=12024-01-26T06:00:00+00:002096.52Leeds Institute for Fluid DynamicsNo abstracthttps://cassyni-user-files-prod.s3.amazonaws.com/7RCyPMiMBRSJEF74Cy391G https://cassyni.com/events/NRzSF5GhuppefUTv85bvjP/seminar/qa https://cassyni.com/slides/outline/NRzSF5GhuppefUTv85bvjP https://cassyni.com/events/NRzSF5GhuppefUTv85bvjP/abstract https://cassyni-user-files-prod.s3.amazonaws.com/PhrD5QQQmr7md4F2bdKr1k https://cassyni.com/events/NRzSF5GhuppefUTv85bvjP?videoPreview=1 Evidence of active sound production by a sharknohttps://cassyni.com/events/NRzSF5GhuppefUTv85bvjP?videoPreview=12025-11-19T15:00:00+00:003406.68Royal Society PublishingUnderwater sound travels five times faster in water than in air and presents an important sensory cue that is used by many marine organisms for orientation, mating, feeding and territory defense. Sharks and rays have been swimming in our oceans for more than 400 million years and possess inner ears to listen to the many sounds in the ocean but are not historically viewed as active sound producers. Three recent reports of several species of rays producing clicks in response to approaching divers have cast doubt on this long prevailing view and resulted in calls for more research into sound production in elasmobranchs. But how do we know what these animals can hear and what they might listen to? In this talk I will give a short introduction into underwater sound, touch briefly on the impacts of man-made noise pollution on marine animals. I then will give a brief overview of what methods researchers, including myself, use to study hearing abilities and sound perception in sharks. Lastly, I will talk about how I came to discover that New Zealand rig sharks can make strange noises and discuss some of the open questions in this field of research. https://cassyni-user-files-prod.s3.amazonaws.com/PhrD5QQQmr7md4F2bdKr1k https://cassyni.com/slides/outline/Nve3HkvEMHNhfEzoiWtizh https://cassyni.com/events/Nve3HkvEMHNhfEzoiWtizh/abstract https://cassyni-user-files-prod.s3.amazonaws.com/5SXo7DqGCZsbFMspggvJZc https://cassyni.com/events/Nve3HkvEMHNhfEzoiWtizh?videoPreview=1 Decoding the RNA language with AI-driven Foundation Modelnohttps://cassyni.com/events/Nve3HkvEMHNhfEzoiWtizh?videoPreview=12025-08-05T13:30:00+00:00888.48NoneUnderstanding the intricate language of plant RNA is essential for uncovering key regulatory elements driving growth, adaptation, and defense. Here, we present PlantRNA-FM, a pioneering AI-driven foundation model that integrates both RNA sequence and structure information from over 1,000 plant species. By training on 54 billion RNA elements, PlantRNA-FM accurately decodes functional motifs and structural patterns, enabling highly precise predictions of gene regulatory functions. In benchmark evaluations, the model outperformed existing approaches, successfully identifying crucial structural features such as those associated with translation efficiency. Experimental validations confirmed that certain RNA structures predicted by PlantRNA-FM promote efficient protein production in plants. Furthermore, our interpretability framework clarifies how the position and nature of these RNA motifs influence gene function, offering a comprehensive view of sequence–structure interplay. This capability not only accelerates the discovery of functional regulatory elements but also opens avenues for engineering RNA-based traits in crops. We anticipate that PlantRNA-FM will catalyze future breakthroughs in plant science, complementing traditional biology to rapidly advance our understanding and design of plant genetic systems.https://cassyni-user-files-prod.s3.amazonaws.com/5SXo7DqGCZsbFMspggvJZc https://cassyni.com/slides/outline/RtURLbmcBJrFUteqUgXEJH https://cassyni.com/events/RtURLbmcBJrFUteqUgXEJH/abstract https://cassyni-user-files-prod.s3.amazonaws.com/4tAQL6Y5n26vNTeqCQEHst https://cassyni.com/events/RtURLbmcBJrFUteqUgXEJH?videoPreview=1 Keys to Opportunity in the Housing Market: How Financial Models Advance and Constrain Low-Income Communitiesnohttps://cassyni.com/events/RtURLbmcBJrFUteqUgXEJH?videoPreview=12023-10-02T08:00:00+00:002554.24 School of Public PolicyThe increasing presence of investor ownership in the single-family housing market since the Great Recession has generated significant interest due to its complex effects on low-income communities and housing opportunity. This analysis synthesizes research on the roles and behaviors of various investor types, including individual landlords, small-scale investors, and large institutional “mega” investors owning thousands of properties across multiple markets. Empirical data reveal that investor ownership expanded as owner-occupancy declined during the housing crisis, with notable spatial heterogeneity across metropolitan areas. Large corporate investors, while comprising only 2–5% of the national single-family rental stock, are highly concentrated in specific cities and neighborhoods, often targeting newer or distressed homes in areas with above-average renter incomes. Evidence indicates that institutional investors contribute to reduced homeownership rates—particularly among Black and African American families—by shrinking owner-occupied housing availability and increasing housing prices. However, their impact on rental prices remains mixed, with some studies showing rent increases linked to market power and others suggesting rent moderation due to increased supply. Institutional landlords also exhibit higher eviction filing rates, though the actual eviction outcomes and maintenance quality remain underexplored. Methodological advances using open-source data processing tools now enable more accurate identification of investor ownership patterns, facilitating targeted policy interventions. Policy recommendations emphasize enhancing property ownership transparency through rental registries, strengthening tenant protections, and implementing regulatory measures such as building inspections and business licensure to mitigate adverse effects while balancing market dynamics. These findings underscore the need for nuanced, data-driven approaches to regulate investor participation in housing markets to promote equitable access and community stability.https://cassyni-user-files-prod.s3.amazonaws.com/4tAQL6Y5n26vNTeqCQEHst https://cassyni.com/slides/outline/59F3PtbZk5azLuCZCZbtQm https://cassyni.com/events/59F3PtbZk5azLuCZCZbtQm/abstract https://cassyni-user-files-prod.s3.amazonaws.com/6bbLvvZdsmkDjS4dLnSDyg https://cassyni.com/events/59F3PtbZk5azLuCZCZbtQm?videoPreview=1 Interdisciplinarity in the Making: Models and Methods in Frontier Sciencenohttps://cassyni.com/events/59F3PtbZk5azLuCZCZbtQm?videoPreview=12023-12-05T09:00:00+00:005742.8 School of Public PolicyThe study investigates interdisciplinarity in frontier bioengineering sciences through an analysis of modeling practices in four laboratories, focusing on how scientists create and justify investigative methods within complex distributed cognitive-cultural systems. Emphasizing the integration of cognitive, social, material, and cultural dimensions, the research employs cognitive ethnography and qualitative analysis to examine how interdisciplinary teams build hybrid models that serve as hubs for integrating diverse concepts, data, and epistemic norms. Two primary modeling approaches are identified: in vitro simulation models in biomedical engineering, which involve iterative construction of ontologically, conceptually, and methodologically hybrid analog devices, and computational modeling in integrative systems biology, which requires synthesizing sparse and heterogeneous biological data through parameter estimation and algorithm development. The findings reveal that model building not only facilitates problem solving but also generates novel conceptual resources, collaborative ecosystems, and enhanced inferential capacities. Challenges arise from epistemic differences between modelers and experimentalists, necessitating hybrid or symbiotic research roles to manage complexity and foster effective interdisciplinary collaboration. The analysis highlights the dynamic, iterative nature of model development, where each model generates new problems and research configurations. The work concludes by proposing the cultivation of interdisciplinary epistemic virtues through educational programs and targeted interventions, underscoring the importance of explicit strategies to support epistemic integration and innovation in interdisciplinary scientific practice.https://cassyni-user-files-prod.s3.amazonaws.com/6bbLvvZdsmkDjS4dLnSDyg https://cassyni.com/slides/outline/7cV4dJqBwNMUhqg7kFWX8h https://cassyni.com/events/7cV4dJqBwNMUhqg7kFWX8h/abstract https://cassyni-user-files-prod.s3.amazonaws.com/KD5H3LW9uJwyAvftJwxRyx https://cassyni.com/events/7cV4dJqBwNMUhqg7kFWX8h?videoPreview=1 Collisionless Shock As A Self-Regulatory Systemnohttps://cassyni.com/events/7cV4dJqBwNMUhqg7kFWX8h?videoPreview=12025-08-14T06:00:00+00:002415.6Journal of Plasma PhysicsCollisionless shocks are one of the most ubiquitous systems in space plasmas. They are one of the most efficient accelerators of charged particles. A collisionless shock is a multiscale system. The acceleration occurs at a scale that greatly exceeds the shock width. Yet, the processes in the whole shock affected space significantly depend on the structure of the shock transition region, in particular, on the ion dynamics inside the transition. The only in situ observations of collisionless shocks are possible only in the heliosphere. These observations show that the shock structure changes with the increase of the Mach number, becoming more and more complex. A collisionless shock is a self-organized system, the main task of which is the fast and stable transfer of the conserved quantities, that is, mass, momentum, and energy, from one side, upstream, to the other side, downstream, while adding entropy. "Fast" means that the transfer occurs at scales much smaller than the MHD scales. "Stable" means that there are not disruptions of substantial changes on average, except those which are caused by variations of ambient conditions. In this approach, the developing shock structure is the one that ensures this transfer. This means that if the transfer stability is not possible without an overshoot, an overshoot has to be formed. If it is not possible without rippling, rippling will develop. Since ions are the main carriers of these conserved quantities, it is ions that are responsible for developing the structure, and it is ions which have to most strongly affected by it. In particular, we show that overshoot plays an important role in regulating ion reflection so that the shock becomes stable.https://cassyni-user-files-prod.s3.amazonaws.com/KD5H3LW9uJwyAvftJwxRyx https://cassyni.com/events/49wqJXJWsAUqg9NZ6b8Zbs/seminar/qa https://cassyni.com/slides/outline/49wqJXJWsAUqg9NZ6b8Zbs https://cassyni.com/events/49wqJXJWsAUqg9NZ6b8Zbs/abstract https://cassyni-user-files-prod.s3.amazonaws.com/QxZfi4MhNtXQ3wioHoZq9p https://cassyni.com/events/49wqJXJWsAUqg9NZ6b8Zbs?videoPreview=1 Is diamagnetism really acausal?nohttps://cassyni.com/events/49wqJXJWsAUqg9NZ6b8Zbs?videoPreview=12025-11-07T14:00:00+00:003563.0UK Metamaterials NetworkDiamagnetism, in which the magnetisation in a medium opposes the direction of an applied magnetic field, is a weak but familiar effect in a wide class of materials. Being weak it is also a linear response to any applied field. The problem is that the existence of diamagnetism is in direct conflict with the requirements of causality as embodied in the familiar Kramers-Kronig relations. Nature doesn’t care about our confusion and diamagnetism exists and (as far as we are aware) physics is constrained by the requirements of causality (effect cannot precede cause). This puzzle has received intermittent attention from time to time over the last hundred years, with a variety of arguments made to resolve the paradox. But none of these, no matter how plausible, reveal the mechanism that resolves the existence of diamagnetism without sacrificing causality. I shall present some of the previous proposals before revealing the resolution of this paradox. https://cassyni-user-files-prod.s3.amazonaws.com/QxZfi4MhNtXQ3wioHoZq9p https://cassyni.com/slides/outline/F2D8KZY4XEfKCRCai8NFYh https://cassyni.com/events/F2D8KZY4XEfKCRCai8NFYh/abstract https://cassyni-user-files-prod.s3.amazonaws.com/MmMcT2A4W5oJUek8fYZmxA https://cassyni.com/events/F2D8KZY4XEfKCRCai8NFYh?videoPreview=1 Theoretical studies towards a negative triangularity tokamak power plantnohttps://cassyni.com/events/F2D8KZY4XEfKCRCai8NFYh?videoPreview=12023-10-12T06:00:00+00:003014.04Journal of Plasma PhysicsExperimental observations show that negative triangularity plasma shaping can significantly improve the energy confinement time of tokamaks. Moreover, unlike the standard positive triangularity shape, negative triangularity plasmas typically cannot access H-mode. Together these two facts may enable an attractive power plant design – the plasma can be heated to reactor-relevant conditions while remaining in L-mode to avoid the material survivability concerns associated with ELMs, yet still achieve sufficiently good confinement for high fusion gain. This potential has motivated the creation of EUROfusion’s Theory, Simulation, Verification, and Validation (TSVV) project on negative triangularity, which is investigating the feasibility of a negative triangularity power plant. In this talk, we will synthesize the most important results including the physical reasons behind the confinement time improvement, how performance scales to new parameter regimes (like spherical tokamaks), insights from reduced transport modeling, the scrape-off layer width, and more. We will connect these results to recent experiments and comment on the prospects for a negative triangularity power plant.https://cassyni-user-files-prod.s3.amazonaws.com/MmMcT2A4W5oJUek8fYZmxA https://cassyni.com/events/9b5Up3RHhCaEoYxM7DNTZF/abstract https://cassyni-user-files-prod.s3.amazonaws.com/BU7AkGxuFWW39jScw2G9C https://cassyni.com/events/QQZEKBLvGJ7KCwwxsfPbH7/seminar/qa https://cassyni.com/slides/outline/QQZEKBLvGJ7KCwwxsfPbH7 https://cassyni.com/events/QQZEKBLvGJ7KCwwxsfPbH7/abstract https://cassyni-user-files-prod.s3.amazonaws.com/7KkFT6dvdK1Gwmy92hGaea https://cassyni.com/events/QQZEKBLvGJ7KCwwxsfPbH7?videoPreview=1 MEMS and 3D printed optics enabled microscopynohttps://cassyni.com/events/QQZEKBLvGJ7KCwwxsfPbH7?videoPreview=12026-03-25T15:00:00+00:003148.04UK Microsystems NetworkAdvanced microscopy systems are becoming increasingly more powerful in resolving the smallest details of life's building blocks or intricate details of advanced materials. At the same time a drive to make imaging systems more compact and integrated is happening, aiming to bring microscopy and other imaging tools directly to the end-user application environments, from biology labs over clinical settings to field work and manufacturing environments. To support this drive, new tools and approaches are needed to miniaturized setups and integrate functionalities. In this talk I will introduce a range of optical micro-electro-mechanical systems (MEMS) scanning devices and affordable optical 3D printing approaches that separately or together can enable miniaturisation of microscopy setups and allow testing of new concepts to solve imaging challenges.https://cassyni-user-files-prod.s3.amazonaws.com/7KkFT6dvdK1Gwmy92hGaea https://cassyni.com/events/KU5BrLsfsiaHorEcsBgbYy/abstract https://cassyni-user-files-prod.s3.amazonaws.com/gN8x4NwsgWx5onFHkehj4 https://cassyni.com/slides/outline/2BP3EREJWhCB8yUMJqxEHK https://cassyni.com/events/2BP3EREJWhCB8yUMJqxEHK/abstract https://cassyni-user-files-prod.s3.amazonaws.com/JRkZsRkRQpJq334VerBbGr https://cassyni.com/events/2BP3EREJWhCB8yUMJqxEHK?videoPreview=1 Fluid Dynamics of Gas Giant Planets: interplay between rapidly rotating turbulence, waves and mean flowsnohttps://cassyni.com/events/2BP3EREJWhCB8yUMJqxEHK?videoPreview=12025-10-02T08:00:00+00:003603.4The Edinburgh Fluid Dynamics Group (EFDG)Jupiter’s colourful bands are sustained by strong east–west winds, known as zonal jets, which penetrate deep into its liquid hydrogen interior. These jets provide a striking example of how rapidly rotating, turbulent flows can self-organize at large scales. Understanding their long-term, nonlinear equilibration and interaction with underlying turbulence and waves remains a major challenge in planetary fluid dynamics. Zonal jets emerge due to the propagation of Rossby waves, large-scale waves in rotating fluids that arise from the variation of the Coriolis force with latitude. In this talk, after a broad introduction to the key physical concepts, I will examine zonal jet dynamics from two complementary perspectives: (1) two-dimensional turbulence, and (2) quasilinear wave–mean flow interactions. Using rapidly rotating laboratory experiments, numerical simulations, and theoretical analysis, I will highlight the central role of Rossby waves in the nonlinear dynamics of turbulent jets, from their emergence to their turbulent mixing properties. While motivated by Jupiter, these mechanisms are generic, with relevance for Earth's oceans, atmosphere, and planetary interiors such as liquid cores.https://cassyni-user-files-prod.s3.amazonaws.com/JRkZsRkRQpJq334VerBbGr https://cassyni.com/slides/outline/FWtMUshUN4992BmwU56Yx5 https://cassyni.com/events/FWtMUshUN4992BmwU56Yx5/abstract https://cassyni-user-files-prod.s3.amazonaws.com/MoLssdEDuy2htHnbexo9Wn https://cassyni.com/events/FWtMUshUN4992BmwU56Yx5?videoPreview=1 AI-informed Rapid Post-earthquake Inspection and Evaluation of Civil Infrastructurenohttps://cassyni.com/events/FWtMUshUN4992BmwU56Yx5?videoPreview=12025-09-15T07:00:00+00:002740.2ArtIStE - Artificial Intelligence in Structural EngineeringIn the aftermath of an earthquake, rapid structural inspection and evaluation are critical to ensure restoration of the normal order of life, work, and production. Traditional manual visual assessments by certified inspectors are slow, risky, and subjective, with limited availability delaying inspections. This lecture presents two approaches for automated rapid post-earthquake safety assessment. The first uses sparse acceleration measurements to define damage-sensitive features, inferred through a convolutional neural network. Validated experimentally at E-Defense in Japan, it proves effective for high-rise buildings. The second employs commercial UAV-collected images and a graphics-based digital twin (GBDT), incorporating finite element (FE) and photo-realistic computer graphics (CG) models. This approach is illustrated for a 45-story building in Guangzhou, China. These strategies enable rapid evaluation and efficient decision-making post-earthquake.https://cassyni-user-files-prod.s3.amazonaws.com/MoLssdEDuy2htHnbexo9Wn https://cassyni.com/events/HVWPnEoTXFHdGNka7btw1F/abstract https://cassyni-user-files-prod.s3.amazonaws.com/P7Kg6o64JpeeAoSm9DLeUN https://cassyni.com/slides/outline/QuETUVWL77bTkxH35UkfRF https://cassyni.com/events/QuETUVWL77bTkxH35UkfRF/abstract https://cassyni-user-files-prod.s3.amazonaws.com/FqgCrQwGwgJDWQLBwyunDt https://cassyni.com/events/QuETUVWL77bTkxH35UkfRF?videoPreview=1 Uncharted Intelligence: AI, Policy, and the Global Reinvention of Scholarly Publishingnohttps://cassyni.com/events/QuETUVWL77bTkxH35UkfRF?videoPreview=12026-01-14T09:00:00+00:003728.16Academic Publishing in EuropeThis dynamic session convenes leaders from tech giants, researchers, librarians, and publishers—both inside and outside the traditional scholarly sphere—to explore how AI is reshaping research communications worldwide. Panelists will spotlight bold projects, creative alliances, and transformative initiatives driving discovery, creativity, and equitable access, with ongoing policy developments providing context in the background. Attendees will gain actionable insights into harnessing cross-sector innovation and collaborative strategies that disrupt, rebuild, and enable thriving scholarly publishing in an era defined by uncharted intelligence.https://cassyni-user-files-prod.s3.amazonaws.com/FqgCrQwGwgJDWQLBwyunDt https://cassyni.com/events/Kxn38HYy7tytT1gkrxdje5/seminar/qa https://cassyni.com/slides/outline/Kxn38HYy7tytT1gkrxdje5 https://cassyni.com/events/Kxn38HYy7tytT1gkrxdje5/abstract https://cassyni-user-files-prod.s3.amazonaws.com/B5zYiXgwuDJDsvVp9cApxv https://cassyni.com/events/Kxn38HYy7tytT1gkrxdje5?videoPreview=1 Antimicrobial Resistance: Just Transitions for Shared Futuresnohttps://cassyni.com/events/Kxn38HYy7tytT1gkrxdje5?videoPreview=12026-03-31T09:00:00+00:007191.52Public HumanitiesThis seminar explores the special journal issue ‘Just Transitions’ as a framework to examine the social, ethical, and ecological dimensions of antimicrobial resistance (AMR). It reflects on how AMR intersects with injustice, marginality, and inequality, and considers how principles of solidarity, inclusivity, and sustainability can guide equitable and shared futures with the microbial world.https://cassyni-user-files-prod.s3.amazonaws.com/B5zYiXgwuDJDsvVp9cApxv https://cassyni.com/slides/outline/DYKZQmdG1arUUiHtiVJtQM https://cassyni.com/events/DYKZQmdG1arUUiHtiVJtQM/abstract https://cassyni-user-files-prod.s3.amazonaws.com/6HrL8BmPKY81KDaL1c7G1c https://cassyni.com/events/DYKZQmdG1arUUiHtiVJtQM?videoPreview=1 Leveraging AI to Enhance Effectiveness in Administration, Analytics, and Leadershipnohttps://cassyni.com/events/DYKZQmdG1arUUiHtiVJtQM?videoPreview=12025-09-25T06:00:00+00:003506.36AAMCThis session offers insights into how AI can drive efficiency and innovation. The speakers highlight practical AI use cases that streamline administrative and operational tasks. Examples include DOMINIQ, a secure chatbot that simplifies access to policies, and applications of AI in research administration, clinical revenue, and faculty productivity through tools like Python, Excel, and Power Automate. The speakers also explore how leaders use GPT models for reflective dialogue to strengthen interpersonal communication. This webinar is part of the Artificial Intelligence in Academic Medicine Webinar Series, hosted by the AAMC. It explores critical concepts, the current landscape, and practical strategies drawn from various perspectives and institutions to support you in navigating the evolving world of AI in academic medicine. For more information, see [the complete series webpage](https://www.aamc.org/about-us/mission-areas/medical-education/artificial-intelligence-ai-academic-medicine-webinar-series). https://cassyni-user-files-prod.s3.amazonaws.com/6HrL8BmPKY81KDaL1c7G1c https://cassyni.com/slides/outline/RPugdofjww5HaRGYsasdbT https://cassyni.com/events/RPugdofjww5HaRGYsasdbT/abstract https://cassyni-user-files-prod.s3.amazonaws.com/CL6751Ezy9TKtsruKYikRC https://cassyni.com/events/RPugdofjww5HaRGYsasdbT?videoPreview=1 Light-Matter Interactions In Time-Varying Nanophotonicsnohttps://cassyni.com/events/RPugdofjww5HaRGYsasdbT?videoPreview=12026-03-18T14:00:00+00:002842.2UK Metamaterials NetworkLight-matter interactions in time-modulated, frequency-dispersive, structured media can be drastically distinct from those in static media. We discuss the joint effect of dispersion and time-dependence on the scattering properties of nanostructures, their interaction with dipolar sources -that can become sinks-, and the existence of conservation laws in these time-dependent systems. We discuss how both gain and loss must be accounted for to properly define the local density of states in time-varying media.https://cassyni-user-files-prod.s3.amazonaws.com/CL6751Ezy9TKtsruKYikRC https://cassyni.com/events/Wq3L9KnWmyAMyHWnUVsRau/seminar/qa https://cassyni.com/slides/outline/Wq3L9KnWmyAMyHWnUVsRau https://cassyni.com/events/Wq3L9KnWmyAMyHWnUVsRau/abstract https://cassyni-user-files-prod.s3.amazonaws.com/4FQDmWjjtTRLR9cLSpvECv https://cassyni.com/events/Wq3L9KnWmyAMyHWnUVsRau?videoPreview=1 Alpha-particle orbits near rational flux surfaces in stellaratorsnohttps://cassyni.com/events/Wq3L9KnWmyAMyHWnUVsRau?videoPreview=12026-02-12T16:00:00+00:003527.8Journal of Plasma PhysicsRecent simulations [1, 2] have shown that, even when the magnetic field of a stellarator possesses nested toroidal flux surfaces, the orbits of passing energetic particles can exhibit islands. These 'drift islands' arise near rational flux surfaces and grow with energy, raising concerns that they could be a source of enhanced alpha transport specific to stellarators. To investigate how stellarators may be optimised to minimise this transport, we begin by deriving invariants that describe the orbits of passing particles in a general stellarator, on both rational and irrational surfaces. Near a rational surface, passing particles conserve an adiabatic invariant associated with the closed rational-surface field lines, which we call the 'transit adiabatic invariant'. We show that certain trapped particles — namely, those that complete many toroidal transits before bouncing — are also affected by the rational surface. They do not conserve the usual second adiabatic invariant but they do conserve the transit invariant, which allows us to describe their orbits analytically. To ensure accurate results even for energetic particles, we compute higher-order corrections to our invariants; the resulting theory agrees extremely well with guiding-centre and full-orbit simulations conducted using ASCOT. Our analytical formulas can be evaluated quickly, meaning they could facilitate current efforts to directly optimise stellarators for alpha confinement by removing the need to simulate all alpha orbits, or by allowing rapid generation of training data for machine learning. [1] R.B. White, A. Bierwage, and S. Ethier, Phys. Plasmas 29, 052511 (2022) [2] R.B. White, Phys. Plasmas 29, 092504 (2022)https://cassyni-user-files-prod.s3.amazonaws.com/4FQDmWjjtTRLR9cLSpvECv https://cassyni.com/events/F1uH4dsK6GUKbAYAZt3Pbs/seminar/qa https://cassyni.com/slides/outline/F1uH4dsK6GUKbAYAZt3Pbs https://cassyni.com/events/F1uH4dsK6GUKbAYAZt3Pbs/abstract https://cassyni-user-files-prod.s3.amazonaws.com/QVjPdsdHFymoefsg683M6E https://cassyni.com/events/F1uH4dsK6GUKbAYAZt3Pbs?videoPreview=1 Deep Learning Closure of the Navier–Stokes Equations for Transition-Continuum Flowsnohttps://cassyni.com/events/F1uH4dsK6GUKbAYAZt3Pbs?videoPreview=12026-02-24T15:00:00+00:003609.0AIAA JournalAccurately predicting complex flows in engineering systems remains a significant challenge. Computationally affordable flow predictions generally require the continuum equations to be solved, though the standard viscous stress, heat flux, and no-slip boundary conditions may be questioned at the sub-continuum Knudsen numbers characteristic of hypersonic flows. We present an adjoint-based, solver-embedded data assimilation method to augment the Navier–Stokes equations with neural network terms and higher-order constitutive equations. These are optimized in-situ using high-performance, Python-native flow solvers that leverage automatic differentiation programming techniques to construct the adjoint equations needed to calibrate models. We present applications to continuum predictions of nonequilibrium hypersonic flows and discuss related efforts to develop deep learning closures for statistical (Monte Carlo) simulations. We also discuss potential applications of adjoint-based machine learning to the prediction and control of complex flows.https://cassyni-user-files-prod.s3.amazonaws.com/QVjPdsdHFymoefsg683M6E https://cassyni.com/events/9amdZ7kYGEPFCJHvxy3bcR/seminar/qa https://cassyni.com/slides/outline/9amdZ7kYGEPFCJHvxy3bcR https://cassyni.com/events/9amdZ7kYGEPFCJHvxy3bcR/abstract https://cassyni-user-files-prod.s3.amazonaws.com/8Qs9F8a2j5B6QhyG9zGqKc https://cassyni.com/events/9amdZ7kYGEPFCJHvxy3bcR?videoPreview=1 Nonlinear estimators for the observation and stabilization of falling liquid filmsnohttps://cassyni.com/events/9amdZ7kYGEPFCJHvxy3bcR?videoPreview=12026-03-25T10:00:00+00:002827.04Royal Society PublishingFalling liquid films are complex physical processes modelled by infinite-dimensional dynamical systems. The interfacial behaviour is characterized by the Reynolds number, a non-dimensional parameter, and above a critical value the uniform film becomes unstable and travelling waves occur. By injecting and removing fluid from the base at discrete locations, we aim to stabilize otherwise unstable flat interfaces, with the additional limitation that observations of the state are restricted to finitely many measurements of the film height. Successful feedback control has recently been achieved in the case of full observations using linear-quadratic regulator (LQR) controls coupled to asymptotic approximations of the Navier–Stokes equations, but restricted observations severely curtailed their performance. In this study, we couple the well-understood full-information feedback control strategy to a nonlinear estimator. The dynamics of the estimator are designed to approximate those of the film, and we apply a forcing term chosen to ensure that measurements of the estimator match the available measurements of the film. Using this method, we restore the performance of the controls to a level approaching their full-information counterparts, even at moderately large Reynolds numbers. We also briefly investigate the effects of noise and the relative positioning of actuators and observers on the resulting dynamics.https://cassyni-user-files-prod.s3.amazonaws.com/8Qs9F8a2j5B6QhyG9zGqKc https://cassyni.com/events/GzXKMzyJFTcoqMWoDQqmf3/seminar/qa https://cassyni.com/slides/outline/GzXKMzyJFTcoqMWoDQqmf3 https://cassyni.com/events/GzXKMzyJFTcoqMWoDQqmf3/abstract https://cassyni-user-files-prod.s3.amazonaws.com/2g7VAY6hHeL1Nk2K28MnhC https://cassyni.com/events/GzXKMzyJFTcoqMWoDQqmf3?videoPreview=1 SDG 12: Advancing Circularity Through Changes in Products, Processes and Policynohttps://cassyni.com/events/GzXKMzyJFTcoqMWoDQqmf3?videoPreview=12026-02-26T09:00:00+00:007224.4Springer Nature Sustainable Development Goals ProgrammeThis webinar brings together two internationally recognized scholars, **Dr. Sudha Goel** and **Dr. Roberto Rinaldi** whose work contributes to advancing circularity across technological, industrial and societal systems. Although circular economy principles are widely promoted, their practical implementation requires interdisciplinary collaboration and evidence‑based strategies that address material flows, technological constraints and governance structures. Dr. Sudha Goel, Professor of Civil Engineering at the Indian Institute of Technology, Kharagpur, India specializes in water quality, waste management and sustainable infrastructure, with a strong focus on resource‑efficient systems in rapidly urbanizing contexts. Dr. Roberto Rinaldi, Associate Professor of Sustainable Chemistry at Imperial College, London, UK is known for his pioneering research on lignocellulosic biomass, catalytic transformations and the development of sustainable materials. Their talks will explore how transitions in product design, production processes and policy frameworks can support the shift toward more circular and resource‑efficient systems. The discussion will highlight the importance of interdisciplinary research, technological innovation and governance mechanisms in enabling more sustainable patterns of production and consumption. This session forms part of a broader webinar series dedicated to advancing knowledge and practice related to responsible production and consumption. This webinar is part of the ongoing SDG Talks series curated by the **SDG 12 Working Group**, under the overarching theme **“Sustainable Industries for SDG 12.”** The series highlights critical dimensions of sustainable practices across diverse sectors, showing innovative approaches to responsible production, consumption, and systemic transformation.https://cassyni-user-files-prod.s3.amazonaws.com/2g7VAY6hHeL1Nk2K28MnhC https://cassyni.com/slides/outline/SNqoEzGGbA95h6yw8YKLXf https://cassyni.com/events/SNqoEzGGbA95h6yw8YKLXf/abstract https://cassyni-user-files-prod.s3.amazonaws.com/9tWMTqxDoxzELU5TB6ZvvS https://cassyni.com/events/SNqoEzGGbA95h6yw8YKLXf?videoPreview=1 SSP Innovation Showcase (Summer 2024)nohttps://cassyni.com/events/SNqoEzGGbA95h6yw8YKLXf?videoPreview=12024-07-18T06:00:00+00:003633.88SSP Society for Scholarly PublishingJoin us for a free webinar highlighting new and exciting industry innovations. Speakers will present their solutions in brief presentations and take your questions. Don’t miss this opportunity to learn about developments in the industry. Participating Companies: CloudSource from SirsiDynix, Alchemist Taxonomy from Hum, Sensus Impact from Silverchair, and SiteFusion ProConsulthttps://cassyni-user-files-prod.s3.amazonaws.com/9tWMTqxDoxzELU5TB6ZvvS https://cassyni.com/slides/outline/SsVQHfuo2ch8gsWpiyc8ny https://cassyni.com/events/SsVQHfuo2ch8gsWpiyc8ny/abstract https://cassyni-user-files-prod.s3.amazonaws.com/EbvHRtJmWQ9Z7EeGRSaNfQ https://cassyni.com/events/SsVQHfuo2ch8gsWpiyc8ny?videoPreview=1 Does AI Promote Equity or Division?: Is AI democratising global knowledge or entrenching digital bias?nohttps://cassyni.com/events/SsVQHfuo2ch8gsWpiyc8ny?videoPreview=12026-02-25T14:35:00+00:001399.64Researcher to ReaderArtificial intelligence (AI) is changing scholarly publishing; but most AI systems are trained on Western datasets. The inherent risks are not just amplifying bias and narrowing perspectives but also marginalising voices from the Global South. This presentation explores how AI may democratise or divide global knowledge, and what safeguards are needed for equity and diversity in research. Are we accelerating equity or colonialism?https://cassyni-user-files-prod.s3.amazonaws.com/EbvHRtJmWQ9Z7EeGRSaNfQ https://cassyni.com/events/4eKDCuoBH1mftMhekSvfqF/seminar/qa https://cassyni.com/slides/outline/4eKDCuoBH1mftMhekSvfqF https://cassyni.com/events/4eKDCuoBH1mftMhekSvfqF/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Db7WURg6hGUtEDnuHXGtyC https://cassyni.com/events/4eKDCuoBH1mftMhekSvfqF?videoPreview=1 Visual priming and speech perception among Samoan speakersnohttps://cassyni.com/events/4eKDCuoBH1mftMhekSvfqF?videoPreview=12026-05-15T01:10:00+00:002452.48Linguistics and Applied Language StudiesThe Samoan language (gagana Sāmoa) has multiple registers, including two registers used commonly in day-to-day speech: T-style and K-style. K-style language is typically heard in contexts associated with fa'a Sāmoa (Samoan way of life) such as at home, in traditional ceremonies or at village meetings, whereas T-style language is typically used in non-Samoan contexts like the workplace, at church, or by TV and radio presenters. The distinction between these two styles is purely phonemic. Where T-style language uses the phonemes /t/, /n/ and /l/, K-style language replaces these with /k/, /ŋ/ and, to a lesser extent, /ɾ/. This study aims to investigate the impact of image-based contextual priming on participants' speech perception when presented with a word containing an ambiguous phoneme between /t/ and /k/.https://cassyni-user-files-prod.s3.amazonaws.com/Db7WURg6hGUtEDnuHXGtyC https://cassyni.com/slides/outline/D3LUzXo6joBf3h47pJFj49 https://cassyni.com/events/D3LUzXo6joBf3h47pJFj49/abstract https://cassyni-user-files-prod.s3.amazonaws.com/SYgMToZqm1PYfR41q8s8JA https://cassyni.com/events/D3LUzXo6joBf3h47pJFj49?videoPreview=1 HCR • Evidence Quality Assessment and Strength of Recommendations in Clinical Practice Guidelinesnohttps://cassyni.com/events/D3LUzXo6joBf3h47pJFj49?videoPreview=12025-11-27T01:00:00+00:003908.6NoneTo further advance academic exchanges and cooperation in global healthcare and rehabilitation, the journal [Healthcare and Rehabilitation (HCR)](https://www.keaipublishing.com/en/journals/healthcare-and-rehabilitation/) is pleased to launch the “Qilu International Academic Lecture on Healthcare and Rehabilitation”. This lecture series aims to build an interdisciplinary, high-quality international exchange platform that brings together top experts and young scholars from around the world to explore the latest research trends and cutting-edge topics in the field. On Nov. 27, 2025, Dr. Yuan Zhang, Assistant Professor at McMaster University and Brock University, delivered a report titled Evidence Quality Assessment and Strength of Recommendations in Clinical Practice Guidelines.https://cassyni-user-files-prod.s3.amazonaws.com/SYgMToZqm1PYfR41q8s8JA https://cassyni.com/slides/outline/NRgaz9bxUrdf3vDf1zfjZP https://cassyni.com/events/NRgaz9bxUrdf3vDf1zfjZP/abstract https://cassyni-user-files-prod.s3.amazonaws.com/PzGPRW7dFTamcoEyoNUphk https://cassyni.com/events/NRgaz9bxUrdf3vDf1zfjZP?videoPreview=1 Diversity Means Better Science (Lightning Talk)nohttps://cassyni.com/events/NRgaz9bxUrdf3vDf1zfjZP?videoPreview=12026-02-25T13:00:00+00:00435.12Researcher to ReaderWe explore why broader perspectives, inclusive practices and cross regional partnerships are driving stronger science, better solutions and breakthrough innovation. Discover how diversity is essential to scientific excellence — and what this means for the future of high impact research.https://cassyni-user-files-prod.s3.amazonaws.com/PzGPRW7dFTamcoEyoNUphk https://cassyni.com/slides/outline/NvLC2qFUvKBi3gkYcRxXph https://cassyni.com/events/NvLC2qFUvKBi3gkYcRxXph/abstract https://cassyni-user-files-prod.s3.amazonaws.com/J2AYttPqF8Vdoe47bcEcUW https://cassyni.com/events/NvLC2qFUvKBi3gkYcRxXph?videoPreview=1 A6 – Enhancing Research Performance Reporting via an Enterprise Data Warehouse and a Self – Service Analytics Portalnohttps://cassyni.com/events/NvLC2qFUvKBi3gkYcRxXph?videoPreview=12026-04-20T09:15:00+00:002713.16Research Analytics SummitEdith Cowan University (ECU) faced persistent challenges with fragmented and inconsistent research performance reporting, making it difficult for staff to benchmark, monitor, and improve research outcomes. Recognising the importance of accessible, reliable data for both university rankings and government funding, ECU launched a university – wide collaborative project to transform its research reporting landscape. The result was the ECU Analytics Portal – a central, self – service platform developed through extensive consultation with staff and benchmarked against sector peers. Built on SharePoint and powered by an Azure – based Enterprise Data Warehouse, the portal provides timely access to research outputs, grants, income, and HDR (higher degree by research) student supervision data. Interactive dashboards and comprehensive documentation support users at every level, from individual researchers to university leadership. This presentation will outline ECU’s journey, from identifying pain points to delivering a user – focused reporting solution, demonstrate the portal and major dashboards, as well as share lessons learned for those seeking to establish accessible, reliable research performance reporting.https://cassyni-user-files-prod.s3.amazonaws.com/J2AYttPqF8Vdoe47bcEcUW https://cassyni.com/slides/outline/HVCYXK8i6H6depWK1WxjqF https://cassyni.com/events/HVCYXK8i6H6depWK1WxjqF/abstract https://cassyni-user-files-prod.s3.amazonaws.com/LwPezTX9974Fb4U83q77wU https://cassyni.com/events/HVCYXK8i6H6depWK1WxjqF?videoPreview=1 E2 – You Can't Be an Analyst without Wordsnohttps://cassyni.com/events/HVCYXK8i6H6depWK1WxjqF?videoPreview=12026-04-20T14:45:00+00:002804.08Research Analytics SummitAs analysts, we talk about data all the time. We prepare high – level presentations, discuss technical details in meetings, and write emails all day long. But what about the words we use in all of these communications? How do we better communicate data so that we are articulate, factual, and understandable? Join your presenters as they stumble over their words in this presentation about communicating data, specifically, written communications, to technical and non – technical audiences in research administration. Not all of our output is in graphical form; nor should it be. Consider infographics, educational one – pagers, editorials, blurbs/sound bites for marketing teams, facts for public consumption, professional society journals, and even peer – reviewed journals. We hope to inspire you to diversify your output!https://cassyni-user-files-prod.s3.amazonaws.com/LwPezTX9974Fb4U83q77wU https://cassyni.com/slides/outline/VqQegQJq4iwVYVk7ysXTyP https://cassyni.com/events/VqQegQJq4iwVYVk7ysXTyP/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Nnpfv2CMna8crmKnxbY6Uv https://cassyni.com/events/VqQegQJq4iwVYVk7ysXTyP?videoPreview=1 F4 – Automating Expenditure Monitoring: Enhancing Decision – Making with Power BI Dashboardsnohttps://cassyni.com/events/VqQegQJq4iwVYVk7ysXTyP?videoPreview=12026-04-21T09:15:00+00:002699.68Research Analytics SummitAs institutions face increasing demands for real – time insights and data – driven decision – making, modernizing legacy reporting systems has become essential. This session will showcase UT San Antonio’s transformation of its Expenditure Monitoring Report from a multi – sheet Excel workbook dependent on hard – coded formulas and manual year – to – year comparisons into an automated, interactive Power BI dashboard connected to the VPR Server for live data refresh. The session is designed to be accessible to a general audience, including research administrators, finance professionals, and institutional leaders, without requiring prior Power BI experience. Attendees will learn how the project streamlined financial reporting, improved accuracy, and enabled leadership to explore trends, projections, and variances through intuitive visualizations and drill – down capabilities. https://cassyni-user-files-prod.s3.amazonaws.com/Nnpfv2CMna8crmKnxbY6Uv https://cassyni.com/slides/outline/3AQ2BVNVN134LekVbJRoYq https://cassyni.com/events/3AQ2BVNVN134LekVbJRoYq/abstract https://cassyni-user-files-prod.s3.amazonaws.com/VBt3kfxmzDRSH8K9ZraNGE https://cassyni.com/events/3AQ2BVNVN134LekVbJRoYq?videoPreview=1 Micro- and Nanosystems for the Diagnosis and Treatment of Infertility and Gynecological Cancernohttps://cassyni.com/events/3AQ2BVNVN134LekVbJRoYq?videoPreview=12026-05-20T09:40:00+00:002158.76Connecting Science, Publishing, and InnovationRecent advances in microrobotics are opening new frontiers in assisted reproductive technologies, particularly in the context of intrauterine and intratubal embryo transfer (IET/IFET). In this talk, I will present our latest developments in bioinspired medical microrobots designed to navigate and operate within the female reproductive tract. Traditional embryo transfer methods often lack precision and can lead to suboptimal implantation outcomes. Our approach uses magnetically guided microcarriers, enabling controlled movement and targeted release of embryos at the most suitable implantation sites. To further enhance the success of these procedures, we emphasize the importance of precise biosensing technologies that allow real-time analysis of embryos and gametes prior to robotic transfer. By integrating advanced biosensing techniques, we can assess key physiological parameters such as embryo viability, morphology, and cellular integrity, providing critical data for decision-making in reproductive treatments. I will discuss the engineering principles behind these medical microsystems, their biocompatibility, and their performance in biologically relevant models. Our technology has the potential to improve the precision of embryo placement, reduce the number of IVF cycles required, and enable more personalized fertility treatments. The integration of biosensing and microrobotics represents a transformative step toward minimally invasive, intelligent, and patient-tailored therapies that could significantly improve reproductive outcomes by ensuring that only the most viable embryos are transferred.https://cassyni-user-files-prod.s3.amazonaws.com/VBt3kfxmzDRSH8K9ZraNGE https://cassyni.com/slides/outline/TNAdSz5CsSAxWLWLX5j6yB https://cassyni.com/events/TNAdSz5CsSAxWLWLX5j6yB/abstract https://cassyni-user-files-prod.s3.amazonaws.com/K47obaPQQGAxCxhvjgKjJW https://cassyni.com/events/TNAdSz5CsSAxWLWLX5j6yB?videoPreview=1 Being Human 2021 - The Future of Storytellingnohttps://cassyni.com/events/TNAdSz5CsSAxWLWLX5j6yB?videoPreview=12021-12-16T09:00:00+00:003331.04NoneThe enduring power of storytelling is undeniable and the printed book has proved resilient, even in the face of digitization and the global pandemic. So what does the future have in store for reading, storytelling, and the ‘text’ in a world where visual media is increasingly dominant? How do advances in digitization change the way we read and experience texts? And how does this change the way that books and other kinds of textual media are made? In this recorded webinar, which was part of the 2021 Being Human Festival, our esteemed panelists draw on their own research projects to explore these questions to demonstrate how important research from across the humanities is in shaping our understanding of the past, present, and future of our cultural heritage and production.https://cassyni-user-files-prod.s3.amazonaws.com/K47obaPQQGAxCxhvjgKjJW https://cassyni.com/events/WL5sqiUEuYRKMxjdmyeS9b/seminar/qa https://cassyni.com/slides/outline/WL5sqiUEuYRKMxjdmyeS9b https://cassyni.com/events/WL5sqiUEuYRKMxjdmyeS9b/abstract https://cassyni-user-files-prod.s3.amazonaws.com/4evacpDHFc9tTzpv1r3D4a https://cassyni.com/events/WL5sqiUEuYRKMxjdmyeS9b?videoPreview=1 Academic reading across disciplines: Examining its dynamic role in EAL university students’ academic successnohttps://cassyni.com/events/WL5sqiUEuYRKMxjdmyeS9b?videoPreview=12026-07-24T04:10:00+00:002687.24Linguistics and Applied Language StudiesAcademic reading is widely regarded as essential in higher education. However, it has often been discussed as a generic concept, despite the fact that academic conventions do not apply uniformly across disciplines. Focusing on EAL international students studying at a university in New Zealand, this talk presents findings of three interconnected studies on how academic reading differs in terms of textual features and its implementation across disciplines, and how those differences influence EAL students’ academic development. Findings of studies highlight that disciplinary textual features alone are insufficient to explain patterns of reading engagement. Rather, EAL students’ academic reading practices are shaped by multiple factors such as pedagogical approaches, the availability of instructional scaffolding, and individual factors such as students’ English academic literacy skills, strategic awareness, and motivation to engage with texts. Research findings indicate that academic reading operates as a discipline-mediated practice whose functions, visibility, and degree of influence vary across academic fields. Although academic reading can provide varying degrees of support for EAL students’ linguistic and cognitive development at surface level, the underlying mechanisms through which it contributes to the students’ academic growth differ substantially across disciplines. Therefore, academic reading should be understood as a dynamic, discipline-sensitive practice with varying impacts on EAL students’ academic success across contexts.https://cassyni-user-files-prod.s3.amazonaws.com/4evacpDHFc9tTzpv1r3D4a https://cassyni.com/slides/outline/A5UUq4RqWQnqqTk4xjzjhX https://cassyni.com/events/A5UUq4RqWQnqqTk4xjzjhX/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Ek4HfQdYLAqJujXMKaGWyt https://cassyni.com/events/A5UUq4RqWQnqqTk4xjzjhX?videoPreview=1 Genetic, Clinical, and Therapeutic Dimensions of Huntington’s Diseasenohttps://cassyni.com/events/A5UUq4RqWQnqqTk4xjzjhX?videoPreview=12026-03-26T09:38:42+00:001082.28Brain and Behavior JournalHuntington disease (HD) is the most common dominantly inherited neurodegenerative disorder, characterized by progressive striatal and cortical neurodegeneration and associated motor, cognitive, and behavioral disturbances. The mutation responsible for the disease is a CAG trinucleotide repeat expansion in the HTT gene that encodes a polyglutamine tract in huntingtin, a ubiquitously expressed protein playing a plethora of functions. Since the identification of the mutation in 1993, research has unraveled key pathological mechanisms of the disease, from toxic protein aggregation and transcriptional dysregulation to mitochondrial impairment and synaptic failure. However, despite these advances, no definitive therapy exists to cure HD. In light of that, there is an urgent need of transformative research unraveling both genetic and biochemical aspects of the disease bridging preclinical insights to clinical solutions. Moreover, the disease is no longer considered only as a brain disorder. A number of studies highlights peripheral pathology, cardiovascular, metabolic, and immune disturbances, that may exacerbate neurodegeneration. This evolving paradigm presents HD as a multi-system condition, where systemic dysfunction intersects with neurological decline, affecting the disease management in patients. This special issue aims at bringing together cutting-edge contributions from leading experts in the field, for illuminating the multifaceted nature of HD.https://cassyni-user-files-prod.s3.amazonaws.com/Ek4HfQdYLAqJujXMKaGWyt https://cassyni.com/events/G1HMVti2BGMk3nypMm7VsB/seminar/qa https://cassyni.com/slides/outline/G1HMVti2BGMk3nypMm7VsB https://cassyni.com/events/G1HMVti2BGMk3nypMm7VsB/abstract https://cassyni-user-files-prod.s3.amazonaws.com/KADePzFUYW3UKeC21CKiML https://cassyni.com/events/G1HMVti2BGMk3nypMm7VsB?videoPreview=1 Advanced Metamaterials Special Webinar: David Cumming , Metamaterials for Imaging and Polarimetrynohttps://cassyni.com/events/G1HMVti2BGMk3nypMm7VsB?videoPreview=12026-05-28T11:00:00+00:003245.16Springer Nature Physics CommunityMetamaterials offer advanced capabilities for manipulating light and sound, enabling ultrathin optics and enhanced functionality in imaging and polarimetry. This work explores the design, fabrication, and application of plasmonic filters and metasurfaces across visible, infrared, and terahertz wavelengths. Plasmonic filters, based on arrays of holes or elliptical structures in thin metal films, demonstrate enhanced extraordinary transmission (up to twice previous designs) with good angular dispersion control and a wide color gamut, facilitating integration onto CMOS focal plane arrays. This enables single-processing step color filter integration and advanced polarization-sensitive imaging, including secure information encoding. Color imaging on single-photon avalanche diode (SPAD) arrays is demonstrated, with 64x64 pixel data reconstructed to 512x512 resolution, aiming for combined color, polarization, and 3D depth ranging. Beyond visible applications, ultralightweight metalenses designed from dielectric meta-atoms achieve diffraction-limited resolution (λ/2 for an F/1 lens at 1064 nm) for earth observation. Terahertz metamaterials are developed for multispectral filtering (visible to terahertz) and bolometric imaging, successfully detecting hidden objects. Furthermore, a terahertz metasurface axicon is demonstrated to generate Bessel beams with rotating polarization, enabling non-contact ellipsometry for precise refractive index characterization of dielectric materials like HDPE. These developments highlight the versatility of metamaterials for highly integrated, multi-functional imaging and sensing systems.https://cassyni-user-files-prod.s3.amazonaws.com/KADePzFUYW3UKeC21CKiML https://cassyni.com/events/WpjUtQ7mLzyNMjGXNQwEQu/abstract https://cassyni-user-files-prod.s3.amazonaws.com/FJBGosdgAAdu62wizwHfCA https://cassyni.com/slides/outline/MSSd83LgQfNsKyqrcnuAgM https://cassyni.com/events/MSSd83LgQfNsKyqrcnuAgM/abstract https://cassyni-user-files-prod.s3.amazonaws.com/AsYNLXaVyYeZ9XQxepeUMt https://cassyni.com/events/MSSd83LgQfNsKyqrcnuAgM?videoPreview=1 Operando X-ray imaging of 3D structures inside lithium batteriesnohttps://cassyni.com/events/MSSd83LgQfNsKyqrcnuAgM?videoPreview=12026-06-03T14:00:00+00:002382.04UK Metamaterials NetworkIt is conventionally difficult to measure lithium ion concentration inside commercially standard battery cell configurations using X-rays because the weak signals of lithium cannot be distinguished by strong signals from other heavy transition metal elements that are present in batteries. Here, we show operando X-ray Compton scattering-computed tomography (XCS-CT) that maps lithium ion concentration distributions and 3D electrode microstructural changes and lithium dendrite growth inside batteries during charging and discharging. Using the insights uncovered by XCS-CT, we develop two advanced processing methods to make electrode microstructure that speeds up lithium ion diffusion, one is directional ice templating for making electrodes with vertical pores for lithium ion batteries with liquid electrolyte, and the other is directional freezing and polymerisation for fabricating cathodes with vertical columns of cathode material and solid polymer electrolyte for solid-state lithium metal batteries that directly incorporate the solid polymer electrolyte within a single process. https://cassyni-user-files-prod.s3.amazonaws.com/AsYNLXaVyYeZ9XQxepeUMt https://cassyni.com/events/gWTGhTgrMEDcwqobfNSQV/seminar/qa https://cassyni.com/slides/outline/gWTGhTgrMEDcwqobfNSQV https://cassyni.com/events/gWTGhTgrMEDcwqobfNSQV/abstract https://cassyni-user-files-prod.s3.amazonaws.com/178FbjVAajA1GFVBPUJBae https://cassyni.com/events/gWTGhTgrMEDcwqobfNSQV?videoPreview=1 Moving without a motility machine—Mechanical dynamics and efficiency of growing chain-mediated bacterial slidingnohttps://cassyni.com/events/gWTGhTgrMEDcwqobfNSQV?videoPreview=12026-09-24T14:00:00+00:004863.04Journal of Biological PhysicsUnlike most cell motility mechanisms, bacterial sliding motility does not rely on any designated motility machinery and is driven by the force of cell growth. In rod-shaped bacteria like <em>Bacillus subtilis</em> and many <em>Clostridium</em> species, sliding is mediated by formation of long cell chains through persistent cell-cell linkage after cell divisions, which keeps the expansion force of cell growth aligned to boost propulsion. As the cell number in a chain grows, the cells are forced to accelerate and can in principle reach a very high speed. We developed a mechanical model framework to investigate the dynamics of growing bacterial chains on substrate surfaces. Our model predicted mechanical stress buildup in the growing chain and the critical stress that would cause the chain to break. The stress-induced chain breakage limits the maximum speed of the chain-mediated sliding. Additionally, our model predicted that mechanical stress can cause either sharp kinks or smooth buckles under different parameter regimes, which can explain corresponding behaviors observed in different bacterial species. Buckling is further found to alleviate the intra-chain stress, hence possibly helping to delay chain breakage. Our model provides a theoretical framework for predicting the dynamics and efficiency of growing chain–mediated bacterial sliding, and suggest cell properties that could optimize the sliding efficiency. Our model provides insights into the physical constraints on bacterial sliding, which could aid future design of synthetic microbial systems.https://cassyni-user-files-prod.s3.amazonaws.com/178FbjVAajA1GFVBPUJBae https://cassyni.com/events/6czVjXvwEvmF23Z9c95S8d/seminar/qa https://cassyni.com/slides/outline/6czVjXvwEvmF23Z9c95S8d https://cassyni.com/events/6czVjXvwEvmF23Z9c95S8d/abstract https://cassyni-user-files-prod.s3.amazonaws.com/4JtmWgiLADu7aZKy2eJ8Tg https://cassyni.com/events/6czVjXvwEvmF23Z9c95S8d?videoPreview=1 From Ideas to Impact: Neuroscience in Wiley's Advanced Portfolionohttps://cassyni.com/events/6czVjXvwEvmF23Z9c95S8d?videoPreview=12026-06-05T12:00:00+00:001660.88Advanced ScienceThis webinar introduces Wiley's Advanced Portfolio offer for neuroscience and related disciplines. Antonia Eisenkoeck, Deputy Editor of Advanced Science and Editor-in-Chief of Advanced Brain, presents the scope and editorial criteria for neuroscience submissions at Advanced Science, and introduces Advanced Brain, Wiley's new flagship open-access journal dedicated to the brain sciences. The session also covers author services and dissemination programs to help researchers maximize the reach of their work.https://cassyni-user-files-prod.s3.amazonaws.com/4JtmWgiLADu7aZKy2eJ8Tg https://cassyni.com/events/GVxafCsS25qZsZZB7hqoGZ/seminar/qa https://cassyni.com/slides/outline/GVxafCsS25qZsZZB7hqoGZ https://cassyni.com/events/GVxafCsS25qZsZZB7hqoGZ/abstract https://cassyni-user-files-prod.s3.amazonaws.com/VereALLMo6fbsv4RHWH8pn https://cassyni.com/events/GVxafCsS25qZsZZB7hqoGZ?videoPreview=1 Collective transitions from orbiting to matrix invasion in three-dimensional multicellular spheroidsnohttps://cassyni.com/events/GVxafCsS25qZsZZB7hqoGZ?videoPreview=12026-07-23T14:00:00+00:004252.68Journal of Biological PhysicsCoordinated cell rotation along a curved matrix interface can sculpt epithelial tissues into spherical morphologies. Subsequently, radially oriented invasion of multicellular strands or branches can occur by local remodelling of the confining matrix. These symmetry-breaking transitions emerge from the dynamic reciprocity between cells and matrix but remain poorly understood. Here we show that epithelial cell spheroids collectively transition from circumferential orbiting to radial invasion via bidirectional interactions with the surrounding matrix curvature. Initially, spheroids exhibit an ellipsoidal shape but become rounded as orbiting occurs. In turn, orbiting along sharper curvature results in locally stronger contractile tractions, which gradually align collagen fibres in the radial direction. Thus, the initially elongated morphology primes the matrix towards subsequent invasion of two to four strands that are roughly aligned with its major axis. We then show that orbiting can be arrested and invasion can be reversed using osmotic pressure. We also investigate coordinated orbiting in mosaic spheroids, showing that a small fraction of cells with weakened cell–cell adhesions can impede collective orbiting but still invade into the matrix. This work elucidates how symmetry breaking in tissue morphogenesis is governed by the interplay of collective migration and the local curvature of the cell–matrix interface, with relevance for embryonic development and tumour progression.https://cassyni-user-files-prod.s3.amazonaws.com/VereALLMo6fbsv4RHWH8pn https://cassyni.com/events/77e6nDaTgPKJ1p63CaNEPw/abstract https://cassyni-user-files-prod.s3.amazonaws.com/X98dPmamaX916tFuM463Dg https://cassyni.com/events/96EWxxAZSDY47XNGZYEApV/seminar/qa https://cassyni.com/slides/outline/96EWxxAZSDY47XNGZYEApV https://cassyni.com/events/96EWxxAZSDY47XNGZYEApV/abstract https://cassyni-user-files-prod.s3.amazonaws.com/BeAovsKsmJS6UznG3itewg https://cassyni.com/events/96EWxxAZSDY47XNGZYEApV?videoPreview=1 Natural Fibres from Colombia: A Sustainable Pathway for Composite Material Innovationnohttps://cassyni.com/events/96EWxxAZSDY47XNGZYEApV?videoPreview=12026-06-17T13:30:00+00:001217.32NoneThis study investigates the potential of Colombian natural fibers for developing sustainable composite materials. Research initially focused on *Guadua* bamboo, a prevalent Colombian resource, for which proprietary technologies were developed for high-quality fiber extraction, cleaning, and alignment. Microstructural analysis revealed bamboo's intelligent gradient structure and varied microfibril orientation, contributing to its mechanical behavior. Experimental characterization of individual bamboo fibers demonstrated competitive properties, including a stiffness of approximately 43 GPa. Unidirectional and cross-ply composites were fabricated, with findings indicating that chemical surface treatments were not required for enhanced composite performance. A significant application explored is a lightweight, sustainable prosthetic foot, optimized through finite element analysis and currently undergoing user trials, demonstrating comfort and good deformation. The research expanded to other indigenous Colombian natural fibers: fique, Tetera, Chiquichiqui, and Heliconia. Microstructural characterization, including tomographic imaging, and individual fiber tensile tests were performed. For fique, a methodology involving multiple span lengths corrected literature-reported Young’s modulus values and showed that 1% NaOH treatment improved composite performance. Chiquichiqui fibers exhibited a unique sponge-like structure with high strength and strains at failure above 25%. Tetera fibers presented a micro-composite arrangement with approximately 500 MPa strength and 3% failure strain. Heliconia fibers, with a beam-like shape, showed strengths around 600 MPa. Future work aims to analyze fiber surfaces for optimal matrix selection, comprehensively characterize composites, and identify their most suitable applications.https://cassyni-user-files-prod.s3.amazonaws.com/BeAovsKsmJS6UznG3itewg https://cassyni.com/slides/outline/VLquycCxqMAXe2MqNmssGZ https://cassyni.com/events/VLquycCxqMAXe2MqNmssGZ/abstract https://cassyni-user-files-prod.s3.amazonaws.com/t7aYc9XHXd4jx5yxB87av https://cassyni.com/events/VLquycCxqMAXe2MqNmssGZ?videoPreview=1 Exposure time, not temperature alone, determines the thermal limits of leaf respiration under heat stress across thermally contrasting biomes.nohttps://cassyni.com/events/VLquycCxqMAXe2MqNmssGZ?videoPreview=12026-06-03T07:50:00+00:00701.68Respiration is a fundamental process that constrains the thermal limits of plant life. Short-term measurements show leaf dark respiration (R) increases near-exponentially with temperature (T) until reaching extreme heat, often >50°C. However, short-term R–T curves do not capture responses over ecologically relevant timescales. Here, we quantified respiratory response to temperature (19-45°C) over one to 11 hours in 50 tree and shrub species growing in thermally-contrasting biomes in Australia and USA including: hot-arid desert, tropical rainforest, temperate woodland, temperate wet-forest, boreal forest, arctic. Respiration remained stable at 19 and 25˚C over the measurement period but generally declined at 35˚C and especially 45˚C which are below lethal thresholds inferred from shorter-term R-T curves. With increasing exposure to 45˚C, R progressively fell below values predicted by standard temperature-response models. The magnitude of this decline was generally larger for species from cooler biomes than warmer regions. Heat sensitivity through time also differed among plant functional types and species with differing leaf mass-leaf area ratios. These results demonstrate that exposure time plays an important role in determining the thermal limits of leaf respiration and reveal inherent species differences in how long respiratory metabolism can be maintained over durations.https://cassyni-user-files-prod.s3.amazonaws.com/t7aYc9XHXd4jx5yxB87av https://cassyni.com/events/BZUYCNQBdWJYUTqq7E8oYR/seminar/qa https://cassyni.com/slides/outline/BZUYCNQBdWJYUTqq7E8oYR https://cassyni.com/events/BZUYCNQBdWJYUTqq7E8oYR/abstract https://cassyni-user-files-prod.s3.amazonaws.com/SDzRUa5dMU6tvRJhRjNwGz https://cassyni.com/events/BZUYCNQBdWJYUTqq7E8oYR?videoPreview=1 Modal Logic in Europenohttps://cassyni.com/events/BZUYCNQBdWJYUTqq7E8oYR?videoPreview=12026-06-10T14:00:00+00:007739.32Logica UniversalisIn this talk, we present a book recently published in the Studies in Universal Logic, Modal Logic in Europe 1930-1959. This book explores the beginning of modern modal logic. The editors, Max Cresswell and Jacques Riche, have translated and commented on several foundational articles, some of them little known, if at all. Starting with a reminder of the early publication of C.I. Lewis's A Survey of Symbolic Logic (1918), the book continues with Oskar Becker's On the Logic of Modalities (1930), Mordchaj Wajsberg, An extended calculus of classes (1933), Robert Feys, The new logic of modalities (1937), and Fomalized systems of Aristotelian modalities (1950). Finally, following this period of syntactical studies, Arnould Bayart proposed his semantics of modal logic in The Soundness of first and second-order S5 modal predicate logic (1958) and The quasi-completeness of second-order S5 and completeness of first-order S5 (1959). 1959 was also the time of Saul Kripke's semantics of modal logic, the end of a period and the start of a new era in the development of the field. Following an introduction on the context of writing this book and Max Cresswell's plan, a short overview of the main results of the other authors, we will mainly concentrate on Feys and Bayart's original contributions. The first, as a typical representative of the so-called "logistique", the second, although in a "rather impenetrable study" (D. Makinson), for his Henkin method in articles that much earlier, until M. Cresswell, even the translation had defied A. Prior and many others. https://cassyni-user-files-prod.s3.amazonaws.com/SDzRUa5dMU6tvRJhRjNwGz https://cassyni.com/slides/outline/RtJgepgHm9HtcL4Gj7Vujj https://cassyni.com/events/RtJgepgHm9HtcL4Gj7Vujj/abstract https://cassyni-user-files-prod.s3.amazonaws.com/4iqoZY7nouog2rJ6o7osVp https://cassyni.com/events/RtJgepgHm9HtcL4Gj7Vujj?videoPreview=1 Atmospheric heat stress outweighs rainfall in regulating herbaceous biomass production in a Mediterranean shrublandnohttps://cassyni.com/events/RtJgepgHm9HtcL4Gj7Vujj?videoPreview=12026-06-04T09:40:00+00:00726.48"Extreme heat and the associated rise in atmospheric water demand are emerging as dominant regulators of plant functioning, yet long-term experimental evidence from natural drylands remains limited. Using a unique 23-year rainfall-manipulation experiment in a Mediterranean shrubland, combined with high-resolution meteorological data and interpretable machine-learning models, we show that atmospheric heat stress—quantified by vapour pressure deficit (VPD) and diurnal temperature range (DTR)—outweighs rainfall in controlling herbaceous biomass production. Biomass declined sharply under high VPD and large DTR even when seasonal precipitation was average, indicating a shift from hydrological drought limitation toward heat-driven “atmospheric drought.” These ecosystem-scale responses mirror physiological mechanisms documented at leaf and canopy levels: stomatal closure under elevated VPD, reduced night-time recovery under large DTR, and intensified soil–atmosphere coupling. Although wet-year legacies moderately buffered drought impacts, they failed to offset productivity losses under extreme heat conditions. Our results reveal that Mediterranean herbaceous communities, traditionally viewed as rainfall-limited, are increasingly governed by atmospheric heat stress. This transition has major implications for forecasting ecosystem responses in climate-change hotspots: rising VPD, heatwaves and thermal extremes will likely shorten growing seasons, suppress biomass even in wet years, and challenge precipitation-based predictions of dryland productivity."https://cassyni-user-files-prod.s3.amazonaws.com/4iqoZY7nouog2rJ6o7osVp https://cassyni.com/events/9auk8GKyH31svzMnMeM8zh/abstract https://cassyni-user-files-prod.s3.amazonaws.com/8cRE3GjQKPo85RPxGfPw1Q https://cassyni.com/slides/outline/VqYmFYtG5Xa8HBoyNYq1Mf https://cassyni.com/events/VqYmFYtG5Xa8HBoyNYq1Mf/abstract https://cassyni-user-files-prod.s3.amazonaws.com/5RrVn36xMMsmqs4zfZxHUi https://cassyni.com/slides/outline/872BDURAmPCiUSXgzTSLfF https://cassyni.com/events/872BDURAmPCiUSXgzTSLfF/abstract https://cassyni-user-files-prod.s3.amazonaws.com/UtehUWLPCcAngYgcBRD8bG https://cassyni.com/events/NvUJbypuw7pLnNpQ17G5Cy/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Gfq4GpZgxaL4hHXD66DyGA https://cassyni.com/events/68uLySb8rgjgGJcDr84QzH/abstract https://cassyni-user-files-prod.s3.amazonaws.com/QLU1dHMYWhLz5qSKe7yQKG https://cassyni.com/events/PRbVbNEWDi7nwBNVQTnnFw/abstract https://cassyni-user-files-prod.s3.amazonaws.com/9iHoCXSYiwZws8WkP3Uxj8 https://cassyni.com/events/Ky4GGahq9WF9uV4vkoQpj7/seminar/qa https://cassyni.com/slides/outline/Ky4GGahq9WF9uV4vkoQpj7 https://cassyni.com/events/Ky4GGahq9WF9uV4vkoQpj7/abstract https://cassyni-user-files-prod.s3.amazonaws.com/8XAABb8yx69kiG1JYvJXu8 https://cassyni.com/events/Ky4GGahq9WF9uV4vkoQpj7?videoPreview=1 Research Ethics and Integritynohttps://cassyni.com/events/Ky4GGahq9WF9uV4vkoQpj7?videoPreview=12026-09-21T13:00:00+00:003929.8Advanced ScienceThis talk will be a deep dive into research ethics and integrity, focusing on human and animal studies, ethical approvals, reporting requirements, and how these considerations inform editorial decisions, as well as AI and its uses.https://cassyni-user-files-prod.s3.amazonaws.com/8XAABb8yx69kiG1JYvJXu8 https://cassyni.com/events/RQBun6pbyYLZ2teimReigV/abstract https://cassyni-user-files-prod.s3.amazonaws.com/GtJgUR1WCL1uDAV5gS2F3U https://cassyni.com/events/B5PPSH4PFGGyiituMD7nQ5/abstract https://cassyni-user-files-prod.s3.amazonaws.com/ScwESSZJtPXztLMuA2PyjU https://cassyni.com/slides/outline/4B1VeStCAsgTGiWZesg1Qq https://cassyni.com/events/4B1VeStCAsgTGiWZesg1Qq/abstract https://cassyni-user-files-prod.s3.amazonaws.com/DYTXYLBcsnsHQaB1vRJceA https://cassyni.com/slides/outline/TNUUhujxJQMx7tkbdAfJ9B https://cassyni.com/events/TNUUhujxJQMx7tkbdAfJ9B/abstract https://cassyni-user-files-prod.s3.amazonaws.com/V3pxocx6YKUv3oaMMG4VwC https://cassyni.com/events/TNUUhujxJQMx7tkbdAfJ9B?videoPreview=1 Rethinking Peer Review: How independent peer review models drive transparency, equity and innovationnohttps://cassyni.com/events/TNUUhujxJQMx7tkbdAfJ9B?videoPreview=12026-02-25T09:00:00+00:003407.08Researcher to ReaderIndependent peer review providers are transforming research evaluation through journal-independent, community-driven models. The discussion will highlight how these initiatives promote transparency, equity, and efficiency in scholarly communication. Panellists will address how independent peer review reduces re-review fatigue, supports early-career researchers, and integrates with preprint and publishing workflows. The panel will provide insights into the evolving peer review landscape and give practical ideas for engaging with these platforms to advance more inclusive and effective models of research assessment.https://cassyni-user-files-prod.s3.amazonaws.com/V3pxocx6YKUv3oaMMG4VwC https://cassyni.com/events/UNMmCVrcdtvTFEpPJ8tgMs/seminar/qa https://cassyni.com/slides/outline/UNMmCVrcdtvTFEpPJ8tgMs https://cassyni.com/events/UNMmCVrcdtvTFEpPJ8tgMs/abstract https://cassyni-user-files-prod.s3.amazonaws.com/GPNhTgupDtJnoVvZop9638 https://cassyni.com/events/UNMmCVrcdtvTFEpPJ8tgMs?videoPreview=1 High recovery water processesnohttps://cassyni.com/events/UNMmCVrcdtvTFEpPJ8tgMs?videoPreview=12023-03-31T08:00:00+00:003896.64ElsevierHigh rate water recovery processes are becoming increasingly important as water scarcity increases, the move to a circular economy advances and ESG drives better environmental performance. The resource industry for example, is under increasing pressure to improve environmental performance to meet ESG responsibilities and this often translates reducing environmental impact associated with water discharges. High recovery processes are able to reduce the volume of contaminant laden streams from cleaned water that is discharged. The reduced contaminant volumes are then more easily managed. Similarly, during periods of drought the value of water increases significantly, and recovering as much clean water as possible becomes a target. The role of membranes in high recovery water treatment processes will be discussed along with approaches to achieving high water recovery and the challenges that arise. Silica as a contaminant that limits water recovery will be considered and approaches to mitigating silica fouling will be discussed. https://cassyni-user-files-prod.s3.amazonaws.com/GPNhTgupDtJnoVvZop9638 https://cassyni.com/events/HzrZgfL92izwJwthP9JtS1/seminar/qa https://cassyni.com/slides/outline/HzrZgfL92izwJwthP9JtS1 https://cassyni.com/events/HzrZgfL92izwJwthP9JtS1/abstract https://cassyni-user-files-prod.s3.amazonaws.com/49kBc76k38yXLdi4EhVWwG https://cassyni.com/events/HzrZgfL92izwJwthP9JtS1?videoPreview=1 Home Dialysis and Incremental Haemodialysisnohttps://cassyni.com/events/HzrZgfL92izwJwthP9JtS1?videoPreview=12024-03-14T11:30:00+00:005809.04Imperial College Renal and Transplant CentreThe who's and how's of these therapy options explained through patient stories Schedule: 1. 11:30-12:00 My Place - Case 1 - Maria F Slon Roblero 2. 12:00-12:30 My Time - Case 2 - Enric Vilar 3. 12:30-13:00 Panel discussionhttps://cassyni-user-files-prod.s3.amazonaws.com/49kBc76k38yXLdi4EhVWwG https://cassyni.com/slides/outline/GWmdyTp8hYhe9Xqj93KwAm https://cassyni.com/events/GWmdyTp8hYhe9Xqj93KwAm/abstract https://cassyni-user-files-prod.s3.amazonaws.com/2opmzaAix2sDPEK15pkgzJ https://cassyni.com/events/BaRi5mvKKmoFV8CEXEvUpu/seminar/qa https://cassyni.com/slides/outline/BaRi5mvKKmoFV8CEXEvUpu https://cassyni.com/events/BaRi5mvKKmoFV8CEXEvUpu/abstract https://cassyni-user-files-prod.s3.amazonaws.com/65mnUocpYrf4XzUwvP3TEv https://cassyni.com/events/BaRi5mvKKmoFV8CEXEvUpu?videoPreview=1 Dynamics of Leading-edge Vortex on an Airfoil: Prediction and Controlnohttps://cassyni.com/events/BaRi5mvKKmoFV8CEXEvUpu?videoPreview=12024-04-23T14:00:00+00:003639.84Experiments in FluidsDynamic stall due to unsteady motion is a common phenomenon in nature and engineering fields. The leading-edge vortex (LEV) or dynamic stall vortex (DSV) is the key structure determining the variation of aerodynamic force and moment in this process. In this talk, we will introduce dynamic models to describe LEV evolution and vortex lift mechanism, where effective velocity and effective angle are found to be two dominant parameters. Then, critical indicators are proposed for whole-life monitoring of dynamic stall, including formation of laminar separation bubble, LEV initiation, LEV centre position and the detachment of LEV. Finally, unsteady flow control strategies based on vortex manipulation are proposed to delay dynamic stall and maintain high lift.https://cassyni-user-files-prod.s3.amazonaws.com/65mnUocpYrf4XzUwvP3TEv https://cassyni.com/events/88RJvxBUuRX3pSSg1idkpV/abstract https://cassyni-user-files-prod.s3.amazonaws.com/7QerascFNLBsWiL923xno8 https://cassyni.com/slides/outline/gpJXd8SHKRDECWDjuhJMK https://cassyni.com/events/gpJXd8SHKRDECWDjuhJMK/abstract https://cassyni-user-files-prod.s3.amazonaws.com/6Taz4fUnFj16ieT5g7DLna https://cassyni.com/events/gpJXd8SHKRDECWDjuhJMK?videoPreview=1 Remote Gestures: A Prototype Performance, Visualisation and Interactionnohttps://cassyni.com/events/gpJXd8SHKRDECWDjuhJMK?videoPreview=12024-08-07T12:00:00+00:00101.32Hong Kong Baptist UniversityThis performance was based on a research project led by Roberto Alonso Trillo and Peter A C Nelson that sought to link creative processes and devices that were difficult to access during the COVID-19 period. Using our native disciplines as a test case, we explored how to remotely connect a violinist and a painter over any distance with minimum latency and maximum creative exchange. This went through multiple research iterations until we arrived at a functional combination of Michael Palumbo’s AllHands protocol for sending low-latency OSC messages, Stanford University’s CCRMA Jacktrip for video and sound, and a range of our own bespoke mapping systems for transferring data from a violin bow into a surround sound system, a 360 cinema, and a robotic calligraphy system. Remote Gestures was a special event where we tested these remote collaboration protocols in a live performance and shared our research with our art, music, and technology communities in Hong Kong.https://cassyni-user-files-prod.s3.amazonaws.com/6Taz4fUnFj16ieT5g7DLna https://cassyni.com/slides/outline/E32QgiJZFmG57sk2iGG2VT https://cassyni.com/events/E32QgiJZFmG57sk2iGG2VT/abstract https://cassyni-user-files-prod.s3.amazonaws.com/5Kz9fok7mQaN44mVVH5hSv https://cassyni.com/events/E32QgiJZFmG57sk2iGG2VT?videoPreview=1 Do you want to be a film star?nohttps://cassyni.com/events/E32QgiJZFmG57sk2iGG2VT?videoPreview=12020-09-29T12:00:00+00:003809.36Hong Kong Baptist UniversityWhat is the difference between Stage and Screen acting? Jump on to this webinar to discover the differences between them, and this will change your view of film acting, and film actors forever. Prof. Michael Bray, programme director of Bachelor of Fine Arts (Honours) in Acting for Global Screen, will walk you through the quality needed to be an excellent screen actor, and how having the right mental approach to the job distinguishes the best from the rest. Prof. Bray is the teacher to many notable students including Finn Jones (Game of Thrones, Iron Fist) and Lashana Lynch (Captain Marvel, No Time to Die). We will also introduce our university after the topic delivered by Prof. Bray.https://cassyni-user-files-prod.s3.amazonaws.com/5Kz9fok7mQaN44mVVH5hSv https://cassyni.com/events/GWGRv8YBT42ZUpDbFxAfDP/abstract https://cassyni-user-files-prod.s3.amazonaws.com/FLAt5udGTeeAcwH2BHKk6a https://cassyni.com/events/GWGRv8YBT42ZUpDbFxAfDP?videoPreview=1 DOTS by Annie Cheung (English)nohttps://cassyni.com/events/GWGRv8YBT42ZUpDbFxAfDP?videoPreview=12022-07-27T12:00:00+00:005613.28Hong Kong Baptist UniversityAbstract not yet added.https://cassyni-user-files-prod.s3.amazonaws.com/FLAt5udGTeeAcwH2BHKk6a https://cassyni.com/slides/outline/BZnPTJ4w4UVY5iWFFUTfVF https://cassyni.com/events/BZnPTJ4w4UVY5iWFFUTfVF/abstract https://cassyni-user-files-prod.s3.amazonaws.com/XQcY4J847BWi3RFCJD3Kan https://cassyni.com/events/BZnPTJ4w4UVY5iWFFUTfVF?videoPreview=1 Political Merit – What's Morality Got to Do With It?nohttps://cassyni.com/events/BZnPTJ4w4UVY5iWFFUTfVF?videoPreview=12024-02-08T12:00:00+00:00538.08Hong Kong Baptist UniversityAssociate Professor of Philosophy Dr. Eirik Harris is a social and political philosopher whose research interrogates the ways that the ideas of these early Chinese thinkers can contribute meaningfully to discussions in contemporary political philosophy and ethics.. Here Dr. Harris introduces the concept of “political merit” and then invites the audience to consider two conflicting perspectives from early Chinese philosophers on both the meaning of the term and the implications that these different meanings might have for us today.https://cassyni-user-files-prod.s3.amazonaws.com/XQcY4J847BWi3RFCJD3Kan https://cassyni.com/slides/outline/Pua9twWkzWSVmviByULRvu https://cassyni.com/events/Pua9twWkzWSVmviByULRvu/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Fw16m3sTZKQfA97DVN7pAz https://cassyni.com/events/Pua9twWkzWSVmviByULRvu?videoPreview=1 Asian Celebrity and the Pandemicnohttps://cassyni.com/events/Pua9twWkzWSVmviByULRvu?videoPreview=12020-06-18T12:00:00+00:004341.04Hong Kong Baptist UniversityIn this virtual roundtable discussion our panellists explore how celebrities in Asia responded to the Covid-19 pandemic. They draw on examples from China, India, Hong Kong and Singapore. They ask, was their input an example of democratisation, resistance, personal branding, or fan communion? Did some celebrities misread the room or provide affective responses for ordinary people to gather around? Did celebrities in Asia speak for or against the imagined nation state or offer new transnational relationships?https://cassyni-user-files-prod.s3.amazonaws.com/Fw16m3sTZKQfA97DVN7pAz https://cassyni.com/slides/outline/96YNDsqJsBj3in2ghnZ2mK https://cassyni.com/events/96YNDsqJsBj3in2ghnZ2mK/abstract https://cassyni-user-files-prod.s3.amazonaws.com/3zTmJad7L7EbcjUjTzgLmL https://cassyni.com/events/96YNDsqJsBj3in2ghnZ2mK?videoPreview=1 Telum Talks To...Robin Ewing, Director of International Journalismnohttps://cassyni.com/events/96YNDsqJsBj3in2ghnZ2mK?videoPreview=12020-10-27T12:00:00+00:00619.08Hong Kong Baptist UniversityThe global pandemic has put everyone in an unprecedented situation, including journalism students who have left their classrooms and ventured into the uncharted waters of the job market. But despite the unforeseen challenges and uncertainties, senior lecturer Robin Ewing believes that the students of journalism will continue to thrive as they have skill sets that set them apart from their competitors. "There is always going to be a need for people who can tell stories, sift through information, verify it, and provide timely and accurate information in an engaging way," she said. In a video interview with Telum Media, the Director of International Journalism of Hong Kong Baptist University also revealed how her university is upping its game by providing students with training on technology such as drone journalism and VR-powered storytelling, and shared tips on how students can create their own brand to impress potential employers.https://cassyni-user-files-prod.s3.amazonaws.com/3zTmJad7L7EbcjUjTzgLmL https://cassyni.com/slides/outline/JUSWPRPzAUMRP4TxNZLdwT https://cassyni.com/events/JUSWPRPzAUMRP4TxNZLdwT/abstract https://cassyni-user-files-prod.s3.amazonaws.com/JXGR3pALVeAvgVKzA7A47p https://cassyni.com/events/JUSWPRPzAUMRP4TxNZLdwT?videoPreview=1 Setting up Ultrasound Device - Ep.41nohttps://cassyni.com/events/JUSWPRPzAUMRP4TxNZLdwT?videoPreview=12022-07-06T12:00:00+00:00122.88Hong Kong Baptist UniversityAn ultrasound device for tracking tongue movement and position during speech production is presented. The system, a Telemed Smart US unit, comprises a beamformer and a probe. The beamformer generates electrical pulses, which the probe converts into acoustic waveforms for transmission. Subsequently, the probe receives reflected acoustic waveforms, enabling detailed observation of articulatory movements. System operation and monitoring are managed by EchoWave 2 software, installed on a connected computer. The setup procedure involves three sequential steps: first, connecting the beamformer's basic unit to a power source and a laptop; second, attaching the probe to the beamformer; and third, initiating the EchoWave 2 software. A green utility icon within the software confirms the successful configuration and operational readiness of the system for data acquisition in phonological studies.https://cassyni-user-files-prod.s3.amazonaws.com/JXGR3pALVeAvgVKzA7A47p https://cassyni.com/events/Jy67S73WbvuUNpzqxzdSCm/abstract https://cassyni-user-files-prod.s3.amazonaws.com/XHT8o8DAzpNgdAvRApkBwt https://cassyni.com/events/Jy67S73WbvuUNpzqxzdSCm?videoPreview=1 The First Cause (Cosmological) Argument: An Interview with Dr. Andrew Lokenohttps://cassyni.com/events/Jy67S73WbvuUNpzqxzdSCm?videoPreview=12024-09-06T12:00:00+00:00451.28Hong Kong Baptist UniversityAbstract not yet added.https://cassyni-user-files-prod.s3.amazonaws.com/XHT8o8DAzpNgdAvRApkBwt https://cassyni.com/slides/outline/VLhoQTdXpYXtuLHyz6aKtH https://cassyni.com/events/VLhoQTdXpYXtuLHyz6aKtH/abstract https://cassyni-user-files-prod.s3.amazonaws.com/AugLXJFtVKcvVsQg8sRC3Y https://cassyni.com/events/VLhoQTdXpYXtuLHyz6aKtH?videoPreview=1 T04 Data Sampling and Predictionsnohttps://cassyni.com/events/VLhoQTdXpYXtuLHyz6aKtH?videoPreview=12023-08-07T12:00:00+00:00481.96Hong Kong Baptist UniversityEvaluating the predictive performance of data mining algorithms on unseen data is critical when standard training approaches use an entire dataset, lacking a ground truth for new predictions. This study addresses this challenge by demonstrating systematic data sampling and prediction methodologies. A standard procedure involves splitting datasets into training and test sets, allowing algorithms to learn patterns on one subset and be evaluated on the other. Two primary strategies for data splitting are presented: a fixed proportion split, such as 70% for training and 30% for testing (with a caution regarding potential biases that can be mitigated through randomization or alternative strategies), and cross-validation, where an algorithm is trained multiple times on different data slices and tested on the remainder, exemplified by a 4-fold split (75% training, 25% testing). The approach was demonstrated using the Orange data mining software and a Titanic dataset. A Data Sampler widget was employed to divide 1,043 records into 731 instances for training and 312 for testing, facilitating the training of a decision tree model. Predictions were then generated for the test set. Evaluation of the model's performance revealed a precision of 84.4%. Further analysis using a Confusion Matrix widget highlighted correct classifications and classification errors, elucidating discrepancies between predicted and actual outcomes. These data sampling and prediction techniques are broadly applicable to various data mining algorithms and provide a foundation for assessing and improving model generalization.https://cassyni-user-files-prod.s3.amazonaws.com/AugLXJFtVKcvVsQg8sRC3Y https://cassyni.com/events/58wC8xvpK7PzjeY94KH2Tw/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Y9Papuz8wqrpCFJYnvZv7Y https://cassyni.com/events/58wC8xvpK7PzjeY94KH2Tw?videoPreview=1 Some More Advanced Topicsnohttps://cassyni.com/events/58wC8xvpK7PzjeY94KH2Tw?videoPreview=12022-11-21T12:00:00+00:003029.2Hong Kong Baptist UniversityAbstract not yet added.https://cassyni-user-files-prod.s3.amazonaws.com/Y9Papuz8wqrpCFJYnvZv7Y https://cassyni.com/slides/outline/RtAa5g6rkLfFsdzRLSCNMT https://cassyni.com/events/RtAa5g6rkLfFsdzRLSCNMT/abstract https://cassyni-user-files-prod.s3.amazonaws.com/4yhioNAakpzY6h6zY6jU4e https://cassyni.com/events/RtAa5g6rkLfFsdzRLSCNMT?videoPreview=1 Being an Art Capital: Key Global Trends Shaping Visual Art in the Next Decadenohttps://cassyni.com/events/RtAa5g6rkLfFsdzRLSCNMT?videoPreview=12023-01-11T12:00:00+00:003711.4Hong Kong Baptist UniversityThe global visual arts landscape has changed dramatically over the last 20 years. Technological disruptions like the phenomena of NFTs not only continue apace but are in fact commonplace. The only guarantee about the future is that change is inevitable. What are some of the key future global trends, and how might these forces shape the visual arts in the next 10 years? This panel offered unique perspectives on the art scene based on the respective contexts that they operate in. This included the importance of engaging with our local audiences and communities, fostering a collaborative spirit amongst traditional art and non-art stakeholders, and the urgent need to embrace diversity at all levels, including our art institutions. While there must be room for artists to create art for art’s sake, the panel acknowledged the potential and shifting role of artists and institutions to contribute to their local communities in supporting civic engagement and deepening involvement in societal issues, for a more inclusive and creative city.https://cassyni-user-files-prod.s3.amazonaws.com/4yhioNAakpzY6h6zY6jU4e https://cassyni.com/slides/outline/49dz3bdmSCHr4ti8xLohf3 https://cassyni.com/events/49dz3bdmSCHr4ti8xLohf3/abstract https://cassyni-user-files-prod.s3.amazonaws.com/7StCA2mq8e7FPQH5n5gfbU https://cassyni.com/events/49dz3bdmSCHr4ti8xLohf3?videoPreview=1 Hong Kong Chamber Project at HKUST — Music Alive!nohttps://cassyni.com/events/49dz3bdmSCHr4ti8xLohf3?videoPreview=12021-05-02T12:00:00+00:004350.28Hong Kong Baptist UniversityNo abstracthttps://cassyni-user-files-prod.s3.amazonaws.com/7StCA2mq8e7FPQH5n5gfbU https://cassyni.com/slides/outline/UMQbK6LUwdRkEaTyt8715P https://cassyni.com/events/UMQbK6LUwdRkEaTyt8715P/abstract https://cassyni-user-files-prod.s3.amazonaws.com/8PonYhaxS7mofeujp1Lacv https://cassyni.com/events/UMQbK6LUwdRkEaTyt8715P?videoPreview=1 Not a Hope in Hellnohttps://cassyni.com/events/UMQbK6LUwdRkEaTyt8715P?videoPreview=12024-11-27T12:00:00+00:006906.88Hong Kong Baptist UniversityA Discussion with Fr. James Dominic Rooney on his upcoming book on the doctrine of hell and why he decided to write on criticizing Universalismhttps://cassyni-user-files-prod.s3.amazonaws.com/8PonYhaxS7mofeujp1Lacv https://cassyni.com/slides/outline/7cBDNPASWQAV6b1hc1BfBs https://cassyni.com/events/7cBDNPASWQAV6b1hc1BfBs/abstract https://cassyni-user-files-prod.s3.amazonaws.com/DW91F9SAbhNtaAPjrzoWHC https://cassyni.com/events/7cBDNPASWQAV6b1hc1BfBs?videoPreview=1 BRICS: De-Americanizing the Internet?nohttps://cassyni.com/events/7cBDNPASWQAV6b1hc1BfBs?videoPreview=12021-05-19T12:00:00+00:005242.88Hong Kong Baptist UniversityWhile the Internet continues to be dominated by the United States in terms of its infrastructure, economics and governance, this domination is increasingly being challenged by the BRICS (Brazil, Russian, India, China and South Africa) countries, notably China, Russia and India. China already has the world’s largest Internet population, followed by India, primarily driven by mobile communications. With the world becoming increasingly mobile, networked and digitized, it is suggested that the BRICS communication flows will help to pluralize information and communication agendas and help create a new global communication order, leading to a de-Americanization of the Internet. The BRICS nations are playing an important role in this process, given their growing presence and assertiveness related to global cyber-issues, despite some strong divergences within the group. The paper discusses the process of de-Americanization within five domains: infrastructure, commerce, regulation, weaponization and surveillance of cyber space, and the developmental dimensions of the Internet. In all five domains, the contributions of the BRICS nations are delineated, especially in relation to the dominant agenda setters for the Internet, namely the US and the digital corporations based there.https://cassyni-user-files-prod.s3.amazonaws.com/DW91F9SAbhNtaAPjrzoWHC https://cassyni.com/slides/outline/Qv3WnkT2naTY2vZb6pEoKT https://cassyni.com/events/Qv3WnkT2naTY2vZb6pEoKT/abstract https://cassyni-user-files-prod.s3.amazonaws.com/PKLKefy1ixCBrsJVvnoMYi https://cassyni.com/events/Qv3WnkT2naTY2vZb6pEoKT?videoPreview=1 Multiscale methods for the study and design of catalytic exhaust systems for internal combustion engine applicationsnohttps://cassyni.com/events/Qv3WnkT2naTY2vZb6pEoKT?videoPreview=12021-09-16T00:15:00+00:003989.68The MacDiarmid Institute for Advanced Materials and NanotechnologyWhile vehicular powertrains shift to efficient electric designs, the majority of the world still relies on internal combustion power sources that require ongoing efforts for improvements in fuel efficiency and emissions control. Mandated requirements worldwide for cleaner, and increasingly fuel-efficient vehicles drive innovation in engine technologies and combustion strategies, as well as catalytic emissions control systems. Next generation technologies are being developed and implemented in engine and powertrain systems for both gasoline and diesel engine vehicles, where engine aftertreatment must meet increasingly specific conditions. As a result, there is an ever increasing need to use advanced, multi-scale analytical and characterization tools to understand and evaluate the effects of new engine and emissions control technologies, their complex interactions with other subsystems and overall performance metrics of vehicles. Discussion on recent and emerging analytical approaches are summarized for the following areas: 1) multifunctional and advanced catalytic emissions control components, 2) emission system substrate properties, 3) impacts of bio-fuels and 4) deposits in EGR coolers and injectors. Multi-scale analytical/characterization tools and methods discussed in this talk are likely to play an increasing role in future internal combustion engines and emissions control products. Numerous examples are discussed which utilize multi-instrument approaches to address key design and operational difficulties common in engine aftertreatment applications. https://cassyni-user-files-prod.s3.amazonaws.com/PKLKefy1ixCBrsJVvnoMYi https://cassyni.com/slides/outline/JzM8aSEPjAbB13bWV6MJfF https://cassyni.com/events/JzM8aSEPjAbB13bWV6MJfF/abstract https://cassyni-user-files-prod.s3.amazonaws.com/JzJCNq5THyoeCikaabhrcE https://cassyni.com/events/JzM8aSEPjAbB13bWV6MJfF?videoPreview=1 Waves in elastic chiral lattice systemsnohttps://cassyni.com/events/JzM8aSEPjAbB13bWV6MJfF?videoPreview=12021-03-30T14:00:00+00:005902.96MetaMATThe lecture gives an overview of the recent work on a new class of chiral elastic waves in lattice systems. It is based on the recent joint work with G. Carta, I. Jones and A. Movchan. One can distinguish between geometrically chiral structures and physically chiral structures, and our emphasis here is on physical chirality whose presence is reflected in the governing equations, whatever the geometry of the overall structure is. The analysis of the dispersion properties reveals a new class of vortex waveforms that characterise the dynamic response of the chiral elastic system and shows the dynamic anisotropy. Special attention is given to the defect modes and chiral Green’s function for discrete systems.https://cassyni-user-files-prod.s3.amazonaws.com/JzJCNq5THyoeCikaabhrcE https://cassyni.com/slides/outline/J12JNSRTStZJBp576YwYDj https://cassyni.com/events/J12JNSRTStZJBp576YwYDj/abstract https://cassyni-user-files-prod.s3.amazonaws.com/BhVepspArGqJDYxafDGGkn https://cassyni.com/events/J12JNSRTStZJBp576YwYDj?videoPreview=1 LALS Staff Seminar 2021nohttps://cassyni.com/events/J12JNSRTStZJBp576YwYDj?videoPreview=12021-03-05T16:00:00+00:003373.24Linguistics and Applied Language StudiesYou’ve heard of three-minute thesis, but what happens after you graduate? Apparently, you lose a whole minute. Kick off the new trimester by getting to know academic staff from the School of Linguistics and Applied Language studies a bit better. In this seminar, staff in the School will each discuss some of their current research. However, there is a catch! Each staff member is limited to two presentation slides and a total presentation time of two minutes. Come watch them efficiently and expertly explain their research! You’ll gain a better understanding of the breadth and wealth of the research being performed by members of the School of Linguistics and Applied Language studies.https://cassyni-user-files-prod.s3.amazonaws.com/BhVepspArGqJDYxafDGGkn https://cassyni.com/slides/outline/StkRS16g9rNqK67VF5L1FT https://cassyni.com/events/StkRS16g9rNqK67VF5L1FT/abstract https://cassyni-user-files-prod.s3.amazonaws.com/YBJEcYLozc9Joo9z1fswxa https://cassyni.com/events/StkRS16g9rNqK67VF5L1FT?videoPreview=1 Energetic and geometric variational principles for computational homogenization and applicationsnohttps://cassyni.com/events/StkRS16g9rNqK67VF5L1FT?videoPreview=12022-04-26T13:00:00+00:004415.4MetaMATThe homogenization of periodic elastic composites can be addressed through the reformulation of the local equations of the mechanical problem into energetic variational principle. We review such principles and describe a computational, FFT-based, approach that has shown effective on a variety of problems. Building on these tools, we propose a novel geometric variational formulation of the problem. This relies on the definition of Hilbert spaces of kinematically and statically admissible tensor fields, whose orthogonality and duality properties will be recalled. These are endowed with specific energetic scalar products that make use of a reference and uniform elasticity tensor. The corresponding strain and stress Green’s operators are introduced and interpreted as orthogonal projection operators in the admissibility spaces. In this context and as an alternative to classical minimum energy principles, two geometric variational principles are investigated with the introduction of functionals that aim at measuring the discrepancy of arbitrary test fields to the kinematic, static or material admissibility conditions of the problem. By relaxing the corresponding local equations, this study aims in particular at laying the groundwork for the homogenization of composites whose constitutive properties are only partially known or uncertain. The local fields in the composite and their macroscopic responses are computed through the minimization of the proposed geometric functionals. To do so, their gradients are computed using the Green’s operators and gradient-based optimization schemes are discussed. A FFT-based implementation of these schemes is proposed and they are assessed numerically on a canonical example for which analytical solutions are available.https://cassyni-user-files-prod.s3.amazonaws.com/YBJEcYLozc9Joo9z1fswxa https://cassyni.com/slides/outline/2CLD7pkSCxgt9dpkirjuZo https://cassyni.com/events/2CLD7pkSCxgt9dpkirjuZo/abstract https://cassyni-user-files-prod.s3.amazonaws.com/7s3BCJpHgwcGki1gYQb7Dp https://cassyni.com/events/2CLD7pkSCxgt9dpkirjuZo?videoPreview=1 High-fidelity observations and modeling of wave breaking dissipation and bubble plumesnohttps://cassyni.com/events/2CLD7pkSCxgt9dpkirjuZo?videoPreview=12022-04-12T10:40:00+00:001592.04Water WavesCombining high-fidelity numerical modeling and field observations, we examine wave-breaking-induced energy dissipation and bubble plumes over a wide range of sea state conditions, including storms with sustained winds up to 22 m/s and significant wave heights up to 10 m. We use a polydisperse two-fluid LES/VOF model (Derakhti & Kirby, 2014) to simulate bubble entrainment and turbulent bubbly flow in short-crested deep water wave breaking events. Bubble contributions to dissipation and momentum transfer between the water and air phases are considered. Using the numerical model results, we examine the statistical characteristics of wave breaking and associated turbulent dissipation rates in a field of intermittent events. We show that convergence of statistics occurs for signals that have minimum length of approximately 1000–3000 wave periods with randomly spaced observations in time and space relative to 3D breaking events. We further show important effects of obscuration of velocity measurements due to entrained bubbles on the estimated turbulent dissipation rates. Observations are recently collected in the North Pacific Ocean and include arrays of surface following SWIFT buoys as well as shipboard winds and optical video systems. Two types of SWIFT buoys are concurrently used with uplooking and downlooking Acoustic Doppler Current Profilers to measure turbulence and image bubble plumes with echograms in a wave-following reference frame. This vertical reference is used throughout the analysis, with important distinctions from the more common mean-sea-level reference frame. Combining the data from both types of SWIFT buoys, we obtain turbulence dissipation rate profiles that extend from sea surface to 3 m depth. The echograms extend to 30 m depth range and indicate bubble plumes reach more than 10 m beneath the surface, with residence time of several wave periods. The volume of bubble plumes is estimated by combining active whitecap coverage and plume depth measurements. Dependencies of the observations on wave age, bulk and spectral steepness, and wind accelerations are explored. Finally, we show that bubble plume statistics are closely linked to wave breaking dissipation, such that one may scale the other.https://cassyni-user-files-prod.s3.amazonaws.com/7s3BCJpHgwcGki1gYQb7Dp https://cassyni.com/slides/outline/VMxpYnpQwnDbXYteWCJCLm https://cassyni.com/events/VMxpYnpQwnDbXYteWCJCLm/abstract https://cassyni-user-files-prod.s3.amazonaws.com/DgF5nbKuNE5nCCepMJNCge https://cassyni.com/events/VMxpYnpQwnDbXYteWCJCLm?videoPreview=1 Dynamics of waves in continuum honeycomb structuresnohttps://cassyni.com/events/VMxpYnpQwnDbXYteWCJCLm?videoPreview=12020-10-28T14:00:00+00:005697.48MetaMATWe overview results on the dynamics of waves (e.g. Schroedinger and Maxwell equations) in honeycomb structures and their deformations. We study phenomena which arise from the presence of Dirac (conical) points in the bulk band structure. These include the existence of robust edge (interface) states, which localize along certain sharp terminations, and along domain walls. We then discuss recent work on the emergence of pseudo-magnetic fields in non-uniformly deformed honeycomb structures. We apply these results to predict Landau-like energy levels in photonic crystals, and present numerical confirmation of the theory.https://cassyni-user-files-prod.s3.amazonaws.com/DgF5nbKuNE5nCCepMJNCge https://cassyni.com/slides/outline/TszPJ7MxE3dd3L58c7huMf https://cassyni.com/events/TszPJ7MxE3dd3L58c7huMf/abstract https://cassyni-user-files-prod.s3.amazonaws.com/NXncq5eaid9iobguPddaDc https://cassyni.com/events/TszPJ7MxE3dd3L58c7huMf?videoPreview=1 12 Labours Seminar Series (Platform 1): A framework for personalised Physiome modellingnohttps://cassyni.com/events/TszPJ7MxE3dd3L58c7huMf?videoPreview=12022-06-01T00:00:00+00:004099.64Auckland Bioengineering InstituteMost human disease (chronic or susceptibility to a virus) seems to have about a 50:50 mix of genetic predisposition and 'environmental' (i.e. non-genetic) association. The MBIE-funded 12 Labours project is attempting to bring both of these factors to bear on three specific medical challenges (the three Exemplar Projects) by building three technology platforms - P1: multiscale modelling; P2: model-based clinical workflows; and P3: a common infrastructure for handing data from wearable and implantable devices. The talk will address one aspect of this challenge for P1. Namely, how do we create a modelling infrastructure that can connect multiscale gene/protein/cell/tissue/organ models with anatomical systems that involve the whole body: the cardiovascular system, the autonomic nervous system, the enteric nervous system, the epithelial integumentary system, the lymphatic system, and the musculoskeletal system (for force transmission). We certainly do not have all the answers to this challenge, but we are beginning to construct what we call 'functional connectivity' maps that we think will help link this whole body connectivity with our standards-based infrastructure for multiscale modelling (based on the CellML and FieldML standards that ABI has pioneered). https://cassyni-user-files-prod.s3.amazonaws.com/NXncq5eaid9iobguPddaDc https://cassyni.com/slides/outline/QvBdMu2ToP6AmcdSVVYLhj https://cassyni.com/events/QvBdMu2ToP6AmcdSVVYLhj/abstract https://cassyni-user-files-prod.s3.amazonaws.com/J4QyhZXk8yhAvXTtgdYB5Q https://cassyni.com/events/QvBdMu2ToP6AmcdSVVYLhj?videoPreview=1 Cultures of Readingnohttps://cassyni.com/events/QvBdMu2ToP6AmcdSVVYLhj?videoPreview=12022-05-04T04:30:00+00:003520.2Stout Research Centre for New Zealand StudiesWhile we often imagine reading as a solitary activity, many of us read as Lydia Wevers read: surrounded by family, community, and culture. Taking Lydia’s Reading on the Farm as a starting point, this panel will think about the cultures of reading that define us in Aotearoa, arising from our pasts, presents, and futures, in discussion with academics and internationally renowned writers Tina Makereti and Ingrid Horrocks.https://cassyni-user-files-prod.s3.amazonaws.com/J4QyhZXk8yhAvXTtgdYB5Q https://cassyni.com/slides/outline/6e7QJiYPMMpJua5xjZVmCq https://cassyni.com/events/6e7QJiYPMMpJua5xjZVmCq/abstract https://cassyni-user-files-prod.s3.amazonaws.com/CETFHdfbJ1EGafGE9HQaf8 https://cassyni.com/events/6e7QJiYPMMpJua5xjZVmCq?videoPreview=1 Existence and large time behavior in hydrodynamic swarmingnohttps://cassyni.com/events/6e7QJiYPMMpJua5xjZVmCq?videoPreview=12021-02-15T15:00:00+00:003362.36Partial Differential Equations and ApplicationsI will discuss recent developments in our study of hydrodynamic swarming driven by symmetric communication kernels. A main question of interest is the emergent behavior which we quantify in terms of the spectral gap of a weighted Laplacian associated with the alignment operator. I will derive threshold conditions which guarantee existence of multiD strong solutions, their large time flocking behavior with long-range kernels, and mention open questions for in the presence of short-range kernels.https://cassyni-user-files-prod.s3.amazonaws.com/CETFHdfbJ1EGafGE9HQaf8 https://cassyni.com/slides/outline/97MRY8n1Yeb813u5gxeVth https://cassyni.com/events/97MRY8n1Yeb813u5gxeVth/abstract https://cassyni-user-files-prod.s3.amazonaws.com/82wcPpfdZcX4xW9zVQEGnS https://cassyni.com/events/97MRY8n1Yeb813u5gxeVth?videoPreview=1 On mean-field models in pedestrian dynamicsnohttps://cassyni.com/events/97MRY8n1Yeb813u5gxeVth?videoPreview=12020-12-14T15:00:00+00:002913.44Partial Differential Equations and ApplicationsIn this talk I will start with a general overview on mean-field models for pedestrian dynamics, outlining the challenges in the derivation and the analysis of the corresponding PDE models. I will then illustrate how this continuum description can be used to understand the effect of inflow and outflow rates as well as the geometry on pedestrian density profiles. Finally I will present how the Bayesian framework can be used to identify parameters in mean field models and quantify uncertainty in those estimates using trajectory data.https://cassyni-user-files-prod.s3.amazonaws.com/82wcPpfdZcX4xW9zVQEGnS https://cassyni.com/slides/outline/PvqB3Ghe7k8CQ9JrVa4JPP https://cassyni.com/events/PvqB3Ghe7k8CQ9JrVa4JPP/abstract https://cassyni-user-files-prod.s3.amazonaws.com/GBhyPHPbWk5hA1yxK3V4HL https://cassyni.com/events/PvqB3Ghe7k8CQ9JrVa4JPP?videoPreview=1 Tackling the Complex Dynamics of Unsteady Flowsnohttps://cassyni.com/events/PvqB3Ghe7k8CQ9JrVa4JPP?videoPreview=12022-02-23T16:00:00+00:003887.76Department of AeronauticsControlling the behavior of flows around air, marine, and ground vehicles can greatly enhance their performance, efficiency, and safety. The high-dimensionality, strong nonlinearity, and multi-scale properties of these flows make effective their control a tremendous challenge. Without the reduction of the state variable dimension and extraction of important dynamics, the application of dynamical systems and control theory for flow control remains a difficult task. We focus on developing physics-based approaches to model and control complex fluid flows by leveraging modal analysis, data science, network science, machine learning, and high-performance computing. Equipped with these toolsets, we extract essential dynamics to facilitate the development of sparse and reduced-order models to design flow control techniques for high-dimensional unsteady fluid flows. We discuss some of the challenges and successes in characterizing, modeling, and controlling unsteady bluff-body wakes and stalled flows over wings. The techniques developed here are validated with DNS and LES. https://cassyni-user-files-prod.s3.amazonaws.com/GBhyPHPbWk5hA1yxK3V4HL https://cassyni.com/slides/outline/MxGNyAdRmGqXrfpojzGdqf https://cassyni.com/events/MxGNyAdRmGqXrfpojzGdqf/abstract https://cassyni-user-files-prod.s3.amazonaws.com/2yJAfpHW4fr4pNt6Ge7shg https://cassyni.com/events/MxGNyAdRmGqXrfpojzGdqf?videoPreview=1 Using Deep-Learning to Solve Complex Multiphase Flowsnohttps://cassyni.com/events/MxGNyAdRmGqXrfpojzGdqf?videoPreview=12021-07-16T14:00:00+00:003590.24Department of Chemical Engineering Euler-Lagrange (EL) and Euler-Euler (EE) techniques have been widely employed for solving particle, droplet, and bubble-laden flows. Since flow around the individual particles is not resolved, the accuracy of the technique depends on the fidelity of the point-particle force laws used. The main focus of this talk is the use of emerging machine learning techniques along with physical insight into the averaging processes involved in the EL and EE techniques can yield closures that recover fully-resolved-like accuracy at orders of magnitude lower cost. The standard EL approach has been limited to (i) particles of size much smaller than the grid-scale and (ii) dilute flows where inter-particle interaction is weak. We will discuss recent developments that begin to ease these limitations. As the grid size approaches the particle size, we face the unpleasant prospect of force law becoming less accurate due to the self-induced flow generated, which corrupts the estimation of undisturbed flow velocity. We will discuss theoretical approaches to properly correcting for the self-induced flow. We will also present the data-driven pairwise interaction extended point-particle (PIEP) model which rigorously extends the point-particle technique to higher volume fractions. This model systematically accounts for the precise location of all the neighboring particles. We will also present results from the application of deep learning where the algorithm is trained to predict multiphase flow.https://cassyni-user-files-prod.s3.amazonaws.com/2yJAfpHW4fr4pNt6Ge7shg https://cassyni.com/events/KV2MjkPoZz4zpWb2HCUGqT/seminar/qa https://cassyni.com/slides/outline/KV2MjkPoZz4zpWb2HCUGqT https://cassyni.com/events/KV2MjkPoZz4zpWb2HCUGqT/abstract https://cassyni-user-files-prod.s3.amazonaws.com/JLVzgvNjSVLVBefipg53tS https://cassyni.com/events/KV2MjkPoZz4zpWb2HCUGqT?videoPreview=1 From Neural PDEs to Neural Operators: Blending data and physics for fast predictionsnohttps://cassyni.com/events/KV2MjkPoZz4zpWb2HCUGqT?videoPreview=12022-04-21T14:00:00+00:004322.6Department of Chemical EngineeringWe will review physics-informed neural network and summarize available extensions for applications in computational mechanics and beyond. We will also introduce new NNs that learn functionals and nonlinear operators from functions and corresponding responses for system identification. The universal approximation theorem of operators is suggestive of the potential of NNs in learning from scattered data any continuous operator or complex system. We first generalize the theorem to deep neural networks, and subsequently we apply it to design a new composite NN with small generalization error, the deep operator network (DeepONet), consisting of a NN for encoding the discrete input function space (branch net) and another NN for encoding the domain of the output functions (trunk net). We demonstrate that DeepONet can learn various explicit operators, e.g., integrals, Laplace transforms and fractional Laplacians, as well as implicit operators that represent deterministic and stochastic differential equations. More generally, DeepOnet can learn multiscale operators spanning across many scales and trained by diverse sources of data simultaneously. https://cassyni-user-files-prod.s3.amazonaws.com/JLVzgvNjSVLVBefipg53tS https://cassyni.com/slides/outline/4faEMEz4QFTNWaJKGYeYHj https://cassyni.com/events/4faEMEz4QFTNWaJKGYeYHj/abstract https://cassyni-user-files-prod.s3.amazonaws.com/AiPAme3uBUdZThp1JdWHx2 https://cassyni.com/events/4faEMEz4QFTNWaJKGYeYHj?videoPreview=1 Encoding Complete Metric Structures by Classical Structuresnohttps://cassyni.com/events/4faEMEz4QFTNWaJKGYeYHj?videoPreview=12022-04-20T10:40:00+00:002278.52Logica UniversalisWe show how to encode, by classical structures, both the objects and the morphisms of the category of complete metric spaces and uniformly continuous maps. The result is a category of, what we call, cognate metric spaces and cognate maps. We show this category relativizes to all models of set theory (unlike the category of complete metric spaces and uniformly continuous maps). We extend this encoding to an encoding of complete metric structures by classical structures. This provide us with a general technique for translating results about infinitary logic on classical structures to the setting of infinitary continuous logic on continuous structures. Our encoding will also allow us to talk about not only the relations between complete metric structures, but also the potential relations between complete metric structures, i.e. those which are satisfied in some larger model of set theory. For example we will show that given any two complete metric structures we can determine if they are potentially isomorphic by looking at any admissible set which contains them both.https://cassyni-user-files-prod.s3.amazonaws.com/AiPAme3uBUdZThp1JdWHx2 https://cassyni.com/slides/outline/FXqXNHDc4Kdr2r8Lt5tEEZ https://cassyni.com/events/FXqXNHDc4Kdr2r8Lt5tEEZ/abstract https://cassyni-user-files-prod.s3.amazonaws.com/MxGn9LbXBSr3qBdqhSCpHU https://cassyni.com/events/FXqXNHDc4Kdr2r8Lt5tEEZ?videoPreview=1 Decidability of Logical Theories and Their Combinationnohttps://cassyni.com/events/FXqXNHDc4Kdr2r8Lt5tEEZ?videoPreview=12021-09-08T10:40:00+00:004510.44Logica UniversalisProvides a comprehensive, self-contained introduction to decidability of first-order theories, using detailed proofs and examples to illustrate and clarify complex concepts Incorporates computability theory and reduction techniques to determine the decidability of theories Illustrates a variety of ways to deduce logical consequences from a theory, including the use of Gentzen calculus for first-order logichttps://cassyni-user-files-prod.s3.amazonaws.com/MxGn9LbXBSr3qBdqhSCpHU https://cassyni.com/events/C5JJ3Vgvz7mD19pnERWGhj/abstract https://cassyni-user-files-prod.s3.amazonaws.com/B9FmhEd24VbKjgd8ud1WJr https://cassyni.com/slides/outline/D4bW8ryys2sMfuenLPybWd https://cassyni.com/events/D4bW8ryys2sMfuenLPybWd/abstract https://cassyni-user-files-prod.s3.amazonaws.com/PRBVNsGG8jGqqys7mgpdWv https://cassyni.com/events/D4bW8ryys2sMfuenLPybWd?videoPreview=1 Towards Design Rules for Light-Responsive Molecular Materialsnohttps://cassyni.com/events/D4bW8ryys2sMfuenLPybWd?videoPreview=12022-07-21T00:15:00+00:003416.28The MacDiarmid Institute for Advanced Materials and NanotechnologyOrganic materials are attractive for technologies that perform functions using sunlight, such as photovoltaics/solar cells and photocatalysts. A key drawcard of organic materials is that their properties can be modified at a molecular level. However, this benefit is difficult to harness when it comes to materials development. The key knowledge barrier that researchers face is our limited understanding of how molecular structure affects solid state photo-physics, which is slowing the progress of these technologies. For example, very few of >35,000 publications on organic photovoltaics (OPVs) have demonstrated improved efficiency.[1] The result is that, although molecular properties can be predicted using quantum chemistry, these powerful tools cannot yet be applied to organic optoelectronics in the same way as drug discovery, where candidate molecules are computationally screened to guide synthesis. The aim of my research is to enable a more systematic approach. In this talk I will cover key parts of my research journey in this area, including: 1) The exploration of chirality as a tool to reduce energetic disorder in organic electronics. [2] 2) New materials and theoretical chemistry methods I have developed to understand intermolecular charge transfer processes. [3] 3) Theoretical insights into energy transport in high-performance organic solar cell materials. [4] 4) Our recent discovery that a well-known organic solar cell molecule generates electric charges directly from light, unlike previous generations of materials. [5]https://cassyni-user-files-prod.s3.amazonaws.com/PRBVNsGG8jGqqys7mgpdWv https://cassyni.com/slides/outline/HWTZfeKbDWnLH36yXcgcHj https://cassyni.com/events/HWTZfeKbDWnLH36yXcgcHj/abstract https://cassyni-user-files-prod.s3.amazonaws.com/AMHcuiKd2hE6Moza2QrDx2 https://cassyni.com/events/HWTZfeKbDWnLH36yXcgcHj?videoPreview=1 Hot Hands: What Data Science Can (and Can't) Tell Us About Basketball Trendsnohttps://cassyni.com/events/HWTZfeKbDWnLH36yXcgcHj?videoPreview=12021-02-27T17:30:00+00:001210.04Mathematical IntelligencerNo abstracthttps://cassyni-user-files-prod.s3.amazonaws.com/AMHcuiKd2hE6Moza2QrDx2 https://cassyni.com/slides/outline/TPRebKG5zfrf8Z713BSyRf https://cassyni.com/events/TPRebKG5zfrf8Z713BSyRf/abstract https://cassyni-user-files-prod.s3.amazonaws.com/LepQC9gFSdbghiGEMhjwSE https://cassyni.com/events/TPRebKG5zfrf8Z713BSyRf?videoPreview=1 Positivity-preserving entropy-based adaptive filtering for shock capturingnohttps://cassyni.com/events/TPRebKG5zfrf8Z713BSyRf?videoPreview=12022-08-18T14:00:00+00:003040.28PyFRThe wide-spread adoption of discontinuous spectral element methods in the industry is hindered by these schemes' lack of robustness in the vicinity of discontinuities. In this talk, I will present a positivity-preserving entropy-based adaptive filtering method as a shock capturing approach. By adapting the filter strength to enforce positivity and a local discrete minimum entropy principle, the resulting approach can robustly resolve strong discontinuities with sub-element resolution, does not require problem-dependent parameter tuning, and can be easily implemented on general unstructured meshes with relatively low computational cost. The efficacy of the approach will be shown in numerical experiments on the Euler and Navier-Stokes equations for problems including extreme shocks, shock-vortex interactions, and complex compressible turbulent flows.https://cassyni-user-files-prod.s3.amazonaws.com/LepQC9gFSdbghiGEMhjwSE https://cassyni.com/slides/outline/8895nf2cspFnMy4W7srfjT https://cassyni.com/events/8895nf2cspFnMy4W7srfjT/abstract https://cassyni-user-files-prod.s3.amazonaws.com/TRMxiM1u2wpG4xDNK4BTCz https://cassyni.com/events/8895nf2cspFnMy4W7srfjT?videoPreview=1 Coherently degenerate state engineering of organic small molecule materials to generate Wannier excitonsnohttps://cassyni.com/events/8895nf2cspFnMy4W7srfjT?videoPreview=12022-10-04T15:00:00+00:003359.4Chemical Physics ImpactOrganic small molecules (OSMs) are promising materials for solar cells, optoelectronic devices, sensing, and OLED, just to name a few. Understanding and furthering the rational design of these OSMs have been the most active area of research for their applications. One of the challenges of OSM research is the generation of the Frenkel excitons upon UV-Vis absorption that are less effective in device performance than the Wannier excitons produced in inorganic materials, such as Si-based. Therefore, the ability to engineer Wannier exciton generating OSM materials is the pinnacle of OSM research. In this presentation, I will describe a coherently degenerate state strategy to design OSMs that are capable of generating Wannier excitons. I will also outline the technique being developed to identify coherently degenerate states in the molecules based on the results of density functional theory calculations. The last part of this presentation will focus on a number of utilizations culminating in pioneering investigations of these newly designed OSMs. The first example will explore the photovoltaics performance of the newly designed materials together with the characterization of the excitonic properties of the materials. The second example will highlight the significant impact of this engineering method on the design of OSMs for other applications. https://cassyni-user-files-prod.s3.amazonaws.com/TRMxiM1u2wpG4xDNK4BTCz https://cassyni.com/events/QRvjv2bLzyVvQmkPaCFu2u/abstract https://cassyni-user-files-prod.s3.amazonaws.com/N9hmvcwkRmA38rb8SinMg2 https://cassyni.com/events/LySkpW6SjVUeKbKBfTyNCm/abstract https://cassyni-user-files-prod.s3.amazonaws.com/7siCicZ1kmHYqXctZUQebp https://cassyni.com/events/UsQ5qziYiQSgHh6ttXKfTs/abstract https://cassyni-user-files-prod.s3.amazonaws.com/MYtD7iwPsvTVPh23DFHar2 https://cassyni.com/events/JW7sFCKAL7w2CSWeBB98sF/abstract https://cassyni-user-files-prod.s3.amazonaws.com/XzURCeE8dMZFdKYCWzqG1L https://cassyni.com/slides/outline/PwFWkiRwAA26bJksn68vrh https://cassyni.com/events/PwFWkiRwAA26bJksn68vrh/abstract https://cassyni-user-files-prod.s3.amazonaws.com/FHMU7Xe5EmGXh2xUde9nqU https://cassyni.com/events/PwFWkiRwAA26bJksn68vrh?videoPreview=1 Just A Gut Feeling: Faecal Microbiota Transplant For Treatment Of Depressionnohttps://cassyni.com/events/PwFWkiRwAA26bJksn68vrh?videoPreview=12025-01-21T13:30:00+00:00409.44Microbiome Virtual International ForumThe microbiota-gut-brain-axis allows bidirectional crosstalk between the brain and the gut microbiota (GM) and is believed to play a central role in the regulation of mood, cognition, behaviour, as well as metabolism, health, biological processes and homeostasis. Manipulation of the GM through faecal microbiota transplant (FMT) is a new, exciting and promising treatment for major depressive disorder (MDD). Studies have demonstrated significant gut dysbiosis in depressed patients compared to healthy cohorts, with an overgrowth of pro-inflammatory microbiota, a reduction in anti-inflammatory species and reduced overall stability and taxonomic richness. FMT allows healthy microbiota to be introduced into the gastrointestinal tract (GIT) and this ultimately leads to a restoration of eubiosis. This presentation provides an overview of the current research into the GM and the FMT as a therapy for depression. We first summarise the current data on the GM and depression. We then discuss the communication through the microbiota-gut-brain-axis and how antidepressant treatment and the GM interact through this. We then review the composition of the dysbiosis found in depressed patients, focusing on how this can be treated by FMT and the future directions in the treatment of depression. https://cassyni-user-files-prod.s3.amazonaws.com/FHMU7Xe5EmGXh2xUde9nqU https://cassyni.com/events/TPqzJkzP35kZKiZ2KhXbty/abstract https://cassyni-user-files-prod.s3.amazonaws.com/A4ym6RDEij5cXSGFabDb1x https://cassyni.com/events/WMmEhVPR5BzvBLnKabSw5P/abstract https://cassyni-user-files-prod.s3.amazonaws.com/SbPpxkCTahC7Y669vB9k1L https://cassyni.com/slides/outline/Qvby5Lkkqnz4xn5Tn1cyB3 https://cassyni.com/events/Qvby5Lkkqnz4xn5Tn1cyB3/abstract https://cassyni-user-files-prod.s3.amazonaws.com/HrufC9d2FMF5pXE6ANn6hc https://cassyni.com/events/Qvby5Lkkqnz4xn5Tn1cyB3?videoPreview=1 Faecal metaproteomics analysis reveals a high cardiovascular risk profile across healthy individuals and heart failure patientsnohttps://cassyni.com/events/Qvby5Lkkqnz4xn5Tn1cyB3?videoPreview=12025-06-03T02:00:00+00:00587.4Microbiome Virtual International ForumThe gut microbiota is a crucial link between diet and cardiovascular disease (CVD). Using fecal metaproteomics, a method that concurrently captures human gut and microbiome proteins, we determined the crosstalk between gut microbiome, diet, gut health, and CVD. Traditional CVD risk factors (age, BMI, sex, blood pressure) explained < 10% of the proteome variance. However, unsupervised human protein-based clustering analysis revealed two distinct CVD risk clusters (low-risk and high-risk) with different blood pressure (by 9 mmHg) and sex-dependent dietary potassium and fiber intake. In the human proteome, the low-risk group had lower angiotensin-converting enzymes, inflammatory proteins associated with neutrophil extracellular trap formation and auto-immune diseases. In the microbial proteome, the low-risk group had higher expression of phosphate acetyltransferase that produces SCFAs, particularly in fiber-fermenting bacteria. This model identified severity across phenotypes in heart failure patients and long-term risk of cardiovascular events in a large population-based cohort. These findings underscore multifactorial gut-to-host mechanisms that may underlie risk factors for CVD.https://cassyni-user-files-prod.s3.amazonaws.com/HrufC9d2FMF5pXE6ANn6hc https://cassyni.com/events/GXByguYRjxbYLhHkRZQZe5/abstract https://cassyni-user-files-prod.s3.amazonaws.com/H644Pja39SASzrm41JLRBt https://cassyni.com/events/MxNsRggyNiYSSH2ZvRR58y/abstract https://cassyni-user-files-prod.s3.amazonaws.com/GA4ojBrgu83vkJrjKpH6hk https://cassyni.com/events/4fgiom3c1hAH6BW5Synyb3/seminar/qa https://cassyni.com/slides/outline/4fgiom3c1hAH6BW5Synyb3 https://cassyni.com/events/4fgiom3c1hAH6BW5Synyb3/abstract https://cassyni-user-files-prod.s3.amazonaws.com/GVvfeZkycDtcQY6HGRaEri https://cassyni.com/events/4fgiom3c1hAH6BW5Synyb3?videoPreview=1 Dialysis In Specific Settings 1100-1230nohttps://cassyni.com/events/4fgiom3c1hAH6BW5Synyb3?videoPreview=12025-09-19T10:00:00+00:006550.92Imperial College Renal and Transplant Centre1100 Renal Replacement Therapy in Intensive Care - Pitfalls and Solutions Marlene Pluess, Berlin Germany 1145 A Special Unit for iHD in Acutely Sick Patients - Anisha Tanna, Renal Consultant, London North West NHS Trust Image credit: [Bagoes Ilhamy (Unsplash)](https://unsplash.com/photos/a-man-laying-in-a-hospital-bed-being-examined-by-a-nurse-Pi_H3N_qbVQ). Image credit: [Bagoes Ilhamy (Unsplash)](https://unsplash.com/photos/a-man-laying-in-a-hospital-bed-being-examined-by-a-nurse-Pi_H3N_qbVQ).https://cassyni-user-files-prod.s3.amazonaws.com/GVvfeZkycDtcQY6HGRaEri https://cassyni.com/events/UMiSa21ENbcjqq8Q2NRs2D/seminar/qa https://cassyni.com/slides/outline/UMiSa21ENbcjqq8Q2NRs2D https://cassyni.com/events/UMiSa21ENbcjqq8Q2NRs2D/abstract https://cassyni-user-files-prod.s3.amazonaws.com/S5kMR9zCD1vwHMo5Ag2v9c https://cassyni.com/events/UMiSa21ENbcjqq8Q2NRs2D?videoPreview=1 Transmitted Variation in Engineering Designnohttps://cassyni.com/events/UMiSa21ENbcjqq8Q2NRs2D?videoPreview=12025-09-24T12:00:00+00:003391.8Data-Centric Engineering JournalWe explore the concept of parameter design applied to the production of glass beads in the manufacture of metal-encapsulated transistors. The main motivation is to complete the analysis hinted at in a publication by Jim Morrison in 1957, which was an early example of discussing the idea of transmitted variation in engineering design, and an influential paper in the development of analytic parameter design as a data-centric engineering activity. Parameter design is a secondary design activity focused on selecting the nominals of the design variables to achieve the required target performance and to simultaneously reduce the variance around the target. Although the 1957 paper is not recent, its approach to engineering design is modern.https://cassyni-user-files-prod.s3.amazonaws.com/S5kMR9zCD1vwHMo5Ag2v9c https://cassyni.com/slides/outline/A5nL5z6awNyqT1zL4pvvsX https://cassyni.com/events/A5nL5z6awNyqT1zL4pvvsX/abstract https://cassyni-user-files-prod.s3.amazonaws.com/5mvQCgTJfBkGnVFowAX2zJ https://cassyni.com/events/A5nL5z6awNyqT1zL4pvvsX?videoPreview=1 Sulfated dietary fiber protects gut microbiota from antibioticsnohttps://cassyni.com/events/A5nL5z6awNyqT1zL4pvvsX?videoPreview=12025-11-12T13:30:00+00:00433.84Microbiome Virtual International ForumAntibiotics, while essential for combating pathogens, also disrupt commensal bacteria, leading to gut microbiota imbalance and associated diseases. However, strategies to mitigate such collateral damage remain largely underexplored. In this study, we found that fucoidan, a marine polysaccharide derived from brown seaweed, provides broad-spectrum growth protection against multiple classes of antibiotics for human gut microbial isolates in vitro and for fecal communities ex vivo. This protective effect is dependent on the structural integrity, molecular weight, and sulfur content of the polysaccharide. Transcriptomic analysis showed that while fucoidan had minimal impact on baseline gene expression, it counteracted about 60% of the genes induced by kanamycin, suggesting a potential inhibition of kanamycin. Mass spectrometry results further showed that this inhibition may be due to the non-specific binding of fucoidan to kanamycin in solution. Finally, animal model experiments revealed that fucoidan facilitated the recovery of gut microbes following antibiotic treatment in vivo. These findings suggest fucoidan could serve as a potential intervention to help protect gut microbiota during antibiotic therapy. Further studies are needed to evaluate its clinical potential and ensure it does not compromise antimicrobial efficacy.https://cassyni-user-files-prod.s3.amazonaws.com/5mvQCgTJfBkGnVFowAX2zJ https://cassyni.com/events/PRKGT55eC6rXUhzKWd1hAu/seminar/qa https://cassyni.com/slides/outline/PRKGT55eC6rXUhzKWd1hAu https://cassyni.com/events/PRKGT55eC6rXUhzKWd1hAu/abstract https://cassyni-user-files-prod.s3.amazonaws.com/LY4cjdKyidqHu9MVBPm3DY https://cassyni.com/events/PRKGT55eC6rXUhzKWd1hAu?videoPreview=1 Recycling Technologies for Minerals Supply Resilience and National Securitynohttps://cassyni.com/events/PRKGT55eC6rXUhzKWd1hAu?videoPreview=12026-02-13T13:00:00+00:004601.92JOM, The Journal of The Minerals, Metals & Materials SocietyThis topic aims to develop and implement recycling and environmental technology strategies that mitigate urgent supply risks and strengthen the availability of critical minerals essential to clean energy, electronics, defense, and other high-tech sectors. We encourage contributions that advance the science and engineering of recovery technologies for critical minerals from primary, secondary, and unconventional sources. Particular emphasis is placed on the development of decentralized recycling infrastructure, rapid response capabilities, sensor systems, closed-loop processes, and adaptive technologies that minimize reliance on imported raw materials. This topic aims to provide a platform for scalable, sustainable, and secure recycling technologies.https://cassyni-user-files-prod.s3.amazonaws.com/LY4cjdKyidqHu9MVBPm3DY https://cassyni.com/events/KTmLbRCvSkPJCHzMm6kQNy/abstract https://cassyni-user-files-prod.s3.amazonaws.com/K4g6h6g2JdJZqN2s4yeoJe https://cassyni.com/slides/outline/XoySkWP3RCEA5yEAjTK8X7 https://cassyni.com/events/XoySkWP3RCEA5yEAjTK8X7/abstract https://cassyni-user-files-prod.s3.amazonaws.com/64nXGtFHe9YdU1pUjgfLEa https://cassyni.com/events/XoySkWP3RCEA5yEAjTK8X7?videoPreview=1 Francis Galton's eugenics and the Royal Society, 1860-1911nohttps://cassyni.com/events/XoySkWP3RCEA5yEAjTK8X7?videoPreview=12026-05-25T12:00:35+00:001272.6Royal Society PublishingFrancis Galton (1822-1911) was the founder of eugenics - an ideologically-driven vision for increasing the so-called "quality" of humanity, which claimed to be grounded in science (and has since been scientifically discredited). He was elected a Fellow of the Royal Society, one of the most prestigious scientific institutions in the world, in 1860; five years before he first articulated his vision for human heredity, and decades before eugenics gained traction in Britain. In this seminar, I discuss three connections between Francis Galton's eugenics and the Royal Society. I explore his involvement in the Evolution Committee and the Royal Society's soirées, as well as the institutional recognition he received in the form of medals, and argue that each of these contributed to the perceived legitimacy of the eugenic claim to scientific authority.https://cassyni-user-files-prod.s3.amazonaws.com/64nXGtFHe9YdU1pUjgfLEa https://cassyni.com/slides/outline/5dcRJH6E9vspZ7XerRPze9 https://cassyni.com/events/5dcRJH6E9vspZ7XerRPze9/abstract https://cassyni-user-files-prod.s3.amazonaws.com/AUBYQg8YMPc9Tue9Rnau4i https://cassyni.com/events/5dcRJH6E9vspZ7XerRPze9?videoPreview=1 Impact of heat stress on colony foundation in antsnohttps://cassyni.com/events/5dcRJH6E9vspZ7XerRPze9?videoPreview=12026-03-17T14:00:00+00:00863.56Royal Society PublishingClimate change not only leads to increased average temperatures but also to episodes of extreme heat that impact the reproduction and survival of organisms. These effects have broader ecological consequences when thermal disturbances affect ecosystem engineers such as ants. The impacts of thermal stress on ant populations have primarily been studied in mature colonies, which are relatively protected against thermal disturbances by the nest architecture and/or various behavioral responses. However, little is known about the effects of thermal stress on founding queens, which are commonly exposed to heat stress during and after the nuptial flight. To study this question, we exposed founding queens of the black garden ant (Lasius niger) to a brief, acute heat stress just after the nuptial flight. We then monitored queen survival and the number of eggs, larvae, pupae and workers produced. We found that the exposure of founding queens to the thermal stress impacted the success of colony foundation via increased queen mortality and reduced likelihood of producing workers, which primarily stemmed from alterations of egg production and/or development. Our results demonstrate the impact of thermal disturbances associated with climate change on the foundation of ant colonies, which could lead to declines in ant populations.https://cassyni-user-files-prod.s3.amazonaws.com/AUBYQg8YMPc9Tue9Rnau4i https://cassyni.com/slides/outline/2B5ByVZZ5j1BXRE6Cm237K https://cassyni.com/events/2B5ByVZZ5j1BXRE6Cm237K/abstract https://cassyni-user-files-prod.s3.amazonaws.com/UUUWxE4vXhxnZ7bHQuXkri https://cassyni.com/events/2B5ByVZZ5j1BXRE6Cm237K?videoPreview=1 Understanding Contest Skill to reduce the welfare costs of aggressionnohttps://cassyni.com/events/2B5ByVZZ5j1BXRE6Cm237K?videoPreview=12026-04-20T09:00:00+00:001631.68Royal Society PublishingWe present the basis for studying skill in animals, its relevance to contest behaviour and animal welfare. The relationship between skill and resource holding potential in agonistic interactions is unknown for most species, but work in hermit crabs suggests a role for accuracy in predicting contest success. Aggression between pigs managed on commercial farms varies between individuals and can cause substantial welfare harms. Therefore, we investigated whether performing contest behaviour skilfully could lead to more efficient and less harmful contests, for both winners and losers.https://cassyni-user-files-prod.s3.amazonaws.com/UUUWxE4vXhxnZ7bHQuXkri https://cassyni.com/events/YJefupYTG1hyuSDgXZS6hK/abstract https://cassyni-user-files-prod.s3.amazonaws.com/FwnW84hFc3sDnm5Vk8rUuL https://cassyni.com/slides/outline/QtvcDZqag9QU9Q2myPpUFF https://cassyni.com/events/QtvcDZqag9QU9Q2myPpUFF/abstract https://cassyni-user-files-prod.s3.amazonaws.com/2kFPk8FVhZ63Eb6gD61Sqk https://cassyni.com/events/QtvcDZqag9QU9Q2myPpUFF?videoPreview=1 Alignment of the Planetary Health Diet with Pregnancy Dietary Guidelines: Insights from Two Cohortsnohttps://cassyni.com/events/QtvcDZqag9QU9Q2myPpUFF?videoPreview=12026-04-07T09:00:00+00:00402.16The Nutrition SocietyThe Planetary Health Diet (PHD) is a mostly plant-based diet that aims to optimise human health whilst minimising the environmental impact of food production. Limited data exists on whether the PHD fulfils key nutritional requirements during pregnancy. This research aimed to examine the PHD in early pregnancy and how it aligns with daily nutrient intake and European Food Safety Authority (EFSA) dietary guidelines. Pregnant women (n=678) from two Irish cohorts (ROLO and MicrobeMom) were analysed. Dietary intakes in early pregnancy were determined using a 3-day food diary and used to calculate PHD Index (PHDI) scores. Women were dichotomised by the median score, to create a ‘High PHDI’ (>88.99) and a ‘Low PHDI’ group (≤88.99). Differences in nutrient intakes and adherence to dietary guidelines between ‘High’ and ‘Low’ PHDI groups were explored using Mann-Whitney U tests for non-normally distributed variables and chi-square tests for categorical variables. Compared to those with a ‘Low’ score, those with a ‘High’ PHDI score reported higher intakes of dietary fibre (g/day) (17.32(13.39,21.08) vs 21.74 (18.28,25.88),p<0.001), iron (mg/day) (10.48(8.48,12.82) vs 12.06(9.48,14.60),p<0.001), folate (µg DFE/day) (250.73 (193.88,312.45) vs 279.57(219.43,356.81),p<0.001), and calcium (mg/day) (837.75(695.36,1056.72) vs 956.57(751.84,1155.03),p<0.001). Compared to those with a ‘Low PHDI’ score, a greater proportion of women in the ‘High PHDI’ group met EFSA recommendations for dietary fibre intake (10.3% vs 28.9%,p<0.001). The PHD may support maternal nutritional adequacy in pregnancy, while promoting environmental sustainability. Our findings provide valuable insights that can inform future dietary recommendations for pregnancy, contributing to both maternal health and planetary well-being.https://cassyni-user-files-prod.s3.amazonaws.com/2kFPk8FVhZ63Eb6gD61Sqk https://cassyni.com/slides/outline/B4oK34EmngpiehGUMHQW93 https://cassyni.com/events/B4oK34EmngpiehGUMHQW93/abstract https://cassyni-user-files-prod.s3.amazonaws.com/hcmJNsxwXTjP5V1otbZuQ https://cassyni.com/events/B4oK34EmngpiehGUMHQW93?videoPreview=1 AMR-GNN: A multi-representation graph neural network framework to enable genomic antimicrobial resistance predictionnohttps://cassyni.com/events/B4oK34EmngpiehGUMHQW93?videoPreview=12026-04-21T02:00:00+00:001292.04Microbiome Virtual International ForumWhole-genome sequencing (WGS) data are an invaluable resource for understanding antimicrobial resistance (AMR) mechanisms. However, WGS data are high-dimensional and the lack of standardised genomic representations is a key barrier to AMR phenotype prediction. To fully explore these high-resolution data, we propose AMR-GNN, a graph deep learning-based framework that integrates multiple genomic representations with graph neural networks (GNN) to enable AMR phenotype prediction from genomic sequence data. We test AMR-GNN with *Pseudomonas aeruginosa*, a clinically relevant Gram-negative bacterial pathogen known for its complex AMR mechanisms. We present AMR-GNN as a proof-of-concept framework designed to address several key problems in AMR phenotype prediction with data-driven machine learning (ML) approaches, including using multiple genomic representations to enhance performance, to mitigate the influence of clonal relationships and to identify informative biomarkers to provide explainability. Follow-up validation on the largest publicly available dataset spanning both Gram-negative and Gram-positive pathogens highlights AMR-GNN’s broad applicability in detecting AMR in diverse and clinically relevant pathogen-drug combinations.https://cassyni-user-files-prod.s3.amazonaws.com/hcmJNsxwXTjP5V1otbZuQ https://cassyni.com/slides/outline/XKQi3iHBBpTCBVqt8MfXpH https://cassyni.com/events/XKQi3iHBBpTCBVqt8MfXpH/abstract https://cassyni-user-files-prod.s3.amazonaws.com/YF34dvCMwSg2ocAnPzyf7U https://cassyni.com/events/XKQi3iHBBpTCBVqt8MfXpH?videoPreview=1 Association Between Dietary Inflammatory Index and Cardiometabolic Risk in Women with Polycystic Ovary Syndromenohttps://cassyni.com/events/XKQi3iHBBpTCBVqt8MfXpH?videoPreview=12026-05-11T11:00:00+00:00358.72The Nutrition SocietyPolycystic ovary syndrome (PCOS) is associated with an increased risk of cardiometabolic disorders, often exacerbated by chronic inflammation. This study aims to investigate the effects of the Dietary Inflammatory Index (DII), a measure of the inflammatory potential of diet, on cardiometabolic risk factors in women with PCOS. We hypothesized positive associations between DII and adverse cardiometabolic profiles in PCOS. In this case-control study, thirty-eight women with PCOS (mean age 21.6 years, BMI 26.3 kg/m²) and 39 age- and BMI-matched healthy controls (mean age 21.2 years, BMI 25.9 kg/m²) were included. Clinical, hormonal, and biochemical assessments were conducted. Dietary intake was assessed using a validated food frequency questionnaire to calculate DII. Women with PCOS exhibited significantly higher fasting insulin, HOMA-IR, and a more adverse lipid profile compared to healthy controls, indicating increased cardiometabolic risk. These differences remained significant after adjusting for the DII, suggesting they are primarily attributable to PCOS, as shown by ANCOVA analysis. In contrast, higher TyG, CMI, and VAI values observed in the PCOS group were largely explained by DII. Furthermore, DII was positively associated with anthropometric and biochemical markers, including waist-to-hip ratio, fasting glucose, triglycerides, and cardiovascular risk indices, indicating that higher dietary inflammation is linked to poorer cardiometabolic health in women with PCOS. A pro-inflammatory dietary pattern, reflected by a higher DII score, is associated with unfavorable cardiometabolic risk factors in women with PCOS. These findings underscore the importance of dietary inflammation in the pathophysiology of PCOS and support anti-inflammatory dietary strategies to mitigate associated risks. https://cassyni-user-files-prod.s3.amazonaws.com/YF34dvCMwSg2ocAnPzyf7U https://cassyni.com/slides/outline/49n6ckDCSzvUoamzM27F3K https://cassyni.com/events/49n6ckDCSzvUoamzM27F3K/abstract https://cassyni-user-files-prod.s3.amazonaws.com/PFNtQJWpgCWJDu2FfWvvZL https://cassyni.com/events/49n6ckDCSzvUoamzM27F3K?videoPreview=1 Mechanical limits shape the eccentric form of rose pricklesnohttps://cassyni.com/events/49n6ckDCSzvUoamzM27F3K?videoPreview=12026-07-31T20:00:00+00:001016.4Royal Society PublishingRose prickles are defensive structures known to many plant enthusiasts. Unlike other stingers in nature that have mostly circular cross-sections, rose prickles have a distinct elliptical shape. The reason for this elliptical cross-section remains poorly understood. In this seminar based on the publication of the same title, we hypothesise that the shape of prickles could be limited by a trade-off between bending, cutting and buckling. Cutting experiments with model prickles of different cross-sectional aspect ratios demonstrated that circular prickles bend rather than cut, while high aspect ratio prickles buckle. Cutting is mainly observed at medium aspect ratios between 2 and 4, which is not inconsistent with biological rose prickles. The mechanical trade-off between bending, cutting and buckling might therefore be a driver behind the elliptical cross-section of rose prickles.https://cassyni-user-files-prod.s3.amazonaws.com/PFNtQJWpgCWJDu2FfWvvZL https://cassyni.com/events/FWico6c9wtan9KbXkfTuAM/abstract https://cassyni-user-files-prod.s3.amazonaws.com/4NMvkAqnwAoAZwymeiCQTQ https://cassyni.com/events/FWico6c9wtan9KbXkfTuAM?videoPreview=1 When Fish Fails to Protect: Interrogating the South Asian Cardiometabolic Paradox in the Era of Aquaculture Transitionnohttps://cassyni.com/events/FWico6c9wtan9KbXkfTuAM?videoPreview=12026-07-28T00:00:00+00:00603.72The Nutrition SocietySouth Asia presents a striking nutritional paradox: populations among the world’s highest fish consumers carry disproportionate cardiometabolic risk at body mass index levels well below disease thresholds for European populations. Marine fish is established as cardioprotective in fatty-fish-consuming coastal populations, yet this benefit appears to break down in South Asian contexts. This commentary interrogates four interlocking mechanisms. First, aquaculture-driven species substitution has replaced omega-3-rich species such as hilsa and coastal sardines with leaner farmed varieties offering only a fraction of the cardioprotective lipid profile. Second, deep frying in high-omega-6 oils substantially degrades polyunsaturated fatty acid bioavailability. Third, heavy metal co-contamination in arsenic- and mercury-affected watersheds may attenuate omega-3 benefits. Fourth, urbanization is eroding fish intake among the highest-risk subgroups, while aggregate dietary data obscure this heterogeneity. Generic eat-more-fish guidance is insufficient; ethnicity-sensitive, sustainability-conscious guidance on species, preparation, and contamination risk is needed to realize fish’s cardioprotective potential in South Asia.https://cassyni-user-files-prod.s3.amazonaws.com/4NMvkAqnwAoAZwymeiCQTQ https://cassyni.com/events/WLfxEwHrN7saRzN4muMiQd/abstract https://cassyni-user-files-prod.s3.amazonaws.com/4SnGbhvzhLBSK7K957LWMk