https://cassyni.com/slides/outline/6273CTNmz1e6nzbG6fT1c1 https://cassyni.com/events/6273CTNmz1e6nzbG6fT1c1/abstract https://cassyni-user-files-prod.s3.amazonaws.com/QYpCDwdBDtxpR2ubBczJQn https://cassyni.com/events/6273CTNmz1e6nzbG6fT1c1?videoPreview=1 In-situ fabrication of ZnO thin film electrode using spent Zn–C batterynohttps://cassyni.com/events/6273CTNmz1e6nzbG6fT1c1?videoPreview=12021-03-09T12:00:00+00:002834.28Discover Applied SciencesIn consideration of effective supercapacitors which are also affordable and lightweight, metal oxides can be considered because of the higher charge storage capability. This work establishes the in situ fabrication of a supercapacitor electrode, employing spent Zn–C batteries as precursor. Every year, extensive number of waste batteries including Zn–C battery end up in landfill, which prolonged the compulsion of waste disposal in landfill and creates environmental and health threat. The transformation of waste battery materials into fabricating components for energy applications, is of great significance for sustainable strategies but it is a challenging work to produce nanomaterials with purity by green methods. The present study proposes the in situ fabrication of ZnO NPs as ultra-thin film on a porous silicon (P-Si) substrate from spent Zn–C battery at 900 °C in the horizontal tube furnace under argon atmosphere. The particles were around 45 nm size and semi-spherical in morphology and showed uniform distributions all over the substrate as a discrete ultra-thin film. The ZnO ultra-thin film basically comprised of several ZnO film layer which stacked with each other periodically and made one thin layer of ~ 390 nm, where the single layer was ~ 45 nm. Formation of ZnO NPs were detected by the analysis of XRD, EDS and XPS. Using cyclic voltammetry as well as impedance spectroscopy in 0.6 M KOH as electrolyte, electrochemical properties of developed electrodes and supercapacitor have also been examined. The ZnO/P-Si electrode demonstrated a highest value of specific capacitance 547 F g−1 at 5 mV s−1 scan rate. Obtained results demonstrate that spent Zn–C battery can be selected to fabricate the energy storage devices which can offer economical, technological and environmental advantages.https://cassyni-user-files-prod.s3.amazonaws.com/QYpCDwdBDtxpR2ubBczJQn https://cassyni.com/slides/outline/15czjcuXbS75Ptsv6Bk1ss https://cassyni.com/events/15czjcuXbS75Ptsv6Bk1ss/abstract https://cassyni-user-files-prod.s3.amazonaws.com/35j1dtzhEA9G5TvU5rX2zJ https://cassyni.com/events/15czjcuXbS75Ptsv6Bk1ss?videoPreview=1 Delivery of precision medicinenohttps://cassyni.com/events/15czjcuXbS75Ptsv6Bk1ss?videoPreview=12023-04-25T07:30:00+00:003557.84Cambridge PrismsPrecision medicine is a rapidly evolving field that holds the promise of transforming healthcare. Realising this promise requires a comprehensive understanding of the complex healthcare systems in which precision medicine is delivered. This webinar will explore the challenges and remaining barriers that must be overcome to translate recent medical advancements into real-world clinical practice with the panel discussing a wide range of topics, including the impact of precision medicine on healthcare systems and existing frameworks, therapies and technology, regulatory and ethical considerations, and much more.https://cassyni-user-files-prod.s3.amazonaws.com/35j1dtzhEA9G5TvU5rX2zJ https://cassyni.com/events/7W76ZmM8779oRh7BHJykDj/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Q447TPMiTwhKwDF4zuc1Ga https://cassyni.com/events/KMZ7DepB2ejyni1z3jEx2Z/seminar/qa https://cassyni.com/slides/outline/KMZ7DepB2ejyni1z3jEx2Z https://cassyni.com/events/KMZ7DepB2ejyni1z3jEx2Z/abstract https://cassyni-user-files-prod.s3.amazonaws.com/THJZ1qFCdsb9PTpRBwpKae https://cassyni.com/events/KMZ7DepB2ejyni1z3jEx2Z?videoPreview=1 Nonadiabatic Landau–Zener–Stückelberg–Majorana transitions, dynamics, and interferencenohttps://cassyni.com/events/KMZ7DepB2ejyni1z3jEx2Z?videoPreview=12023-07-26T13:00:00+00:003502.04Physics ReportsSince the pioneering works by Landau, Zener, Stuckelberg, and Majorana (LZSM), it has been known that driving a quantum two-level system results in tunneling between its states. Even though the interference between these transitions is known to be important, it is only recently that it became both accessible, controllable, and useful for manipulating a growing number of quantum systems. In reference [1], we study systematically various aspects of LZSM physics and review the relevant literature, significantly expanding our earlier review article [2].https://cassyni-user-files-prod.s3.amazonaws.com/THJZ1qFCdsb9PTpRBwpKae https://cassyni.com/events/SGdZsDsXB4VmHX1ZRAotBF/seminar/qa https://cassyni.com/slides/outline/SGdZsDsXB4VmHX1ZRAotBF https://cassyni.com/events/SGdZsDsXB4VmHX1ZRAotBF/abstract https://cassyni-user-files-prod.s3.amazonaws.com/AiJJRkWEyPrP23XvE3jU8n https://cassyni.com/events/SGdZsDsXB4VmHX1ZRAotBF?videoPreview=1 The Decision Problem for Effective Proceduresnohttps://cassyni.com/events/SGdZsDsXB4VmHX1ZRAotBF?videoPreview=12023-06-14T14:00:00+00:006124.52Logica UniversalisThe “somewhat vague, intuitive” notion from computability theory of an effective procedure (method) or algorithm can be fairly precisely defined even if it is not sufficiently formal and precise to belong to mathematics proper (in a narrow sense)—and even if (as many have asserted) for that reason the Church–Turing thesis is unprovable. It is proved logically that the class of effective procedures is not decidable, i.e., that there is no effective procedure for ascertaining whether a given procedure is effective. This result is proved directly from the notion itself of an effective procedure, without reliance on any (partly) mathematical lemma, conjecture, or thesis invoking recursiveness or Turing-computability. In fact, there is no reliance on anything very mathematical. The proof does not even appeal to a precise definition of ‘effective procedure’. Instead, it relies solely and entirely on a basic grasp of the intuitive notion of an effective procedure. Though the result that effectiveness is undecidable is not surprising, it is also not without significance. It has the consequence, for example, that the solution to a decision problem, if it is to be complete, must be accompanied by a separate argument that the proposed ascertainment procedure invariably terminates with the correct verdict.https://cassyni-user-files-prod.s3.amazonaws.com/AiJJRkWEyPrP23XvE3jU8n https://cassyni.com/events/4Y6yq9QRrv8MUmjH35RDUq/seminar/qa https://cassyni.com/slides/outline/4Y6yq9QRrv8MUmjH35RDUq https://cassyni.com/events/4Y6yq9QRrv8MUmjH35RDUq/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Syd2mwb65r9u2GkNahogzi https://cassyni.com/events/4Y6yq9QRrv8MUmjH35RDUq?videoPreview=1 Session 1: Aeroelastic modellingnohttps://cassyni.com/events/4Y6yq9QRrv8MUmjH35RDUq?videoPreview=12023-10-05T08:00:00+00:006015.6Brahmal Vasudevan Institute for Sustainable Aviation at Imperial College London**Chair: Rafael Palacios (Imperial College)**https://cassyni-user-files-prod.s3.amazonaws.com/Syd2mwb65r9u2GkNahogzi https://cassyni.com/events/FQNGrBdyWzJq13ZJeceuRf/seminar/qa https://cassyni.com/slides/outline/FQNGrBdyWzJq13ZJeceuRf https://cassyni.com/events/FQNGrBdyWzJq13ZJeceuRf/abstract https://cassyni-user-files-prod.s3.amazonaws.com/DiqPVUmvSk8U7sEH3EDbe6 https://cassyni.com/events/FQNGrBdyWzJq13ZJeceuRf?videoPreview=1 Less overall, but more of the same: drivers of insect population trends lead to community homogenizationnohttps://cassyni.com/events/FQNGrBdyWzJq13ZJeceuRf?videoPreview=12023-08-10T10:00:00+00:003492.64Royal Society PublishingThe continuing decline in the diversity and biomass of insects and other arthropods has caused great concern not only among scientists, but also among society, policymakers and stakeholders. A major reason for this is that many ecosystem services depend on diverse insect communities. Despite numerous studies on the dynamics of insect communities, their causes are still not fully understood. Rather than focusing on additional evidence of population declines, a new special feature published in *Biology Letters* addresses the causes and consequences of population and diversity trends, aiming at a better mechanistic understanding of the observed dynamics.https://cassyni-user-files-prod.s3.amazonaws.com/DiqPVUmvSk8U7sEH3EDbe6 https://cassyni.com/slides/outline/YCSSY49hqv4fW9q9n2Xya5 https://cassyni.com/events/YCSSY49hqv4fW9q9n2Xya5/abstract https://cassyni-user-files-prod.s3.amazonaws.com/JFgrphRUHb2xitqkGmoeBQ https://cassyni.com/events/YCSSY49hqv4fW9q9n2Xya5?videoPreview=1 ParaSol: Thread-Level Speculation for Modern High-Performance Coresnohttps://cassyni.com/events/YCSSY49hqv4fW9q9n2Xya5?videoPreview=12023-09-12T08:00:00+00:001963.88HiPEDS CentreTo scale ILP, designers build deeper and wider out-of-order superscalar CPUs. However, this approach incurs quadratic scaling complexity, area, and energy costs with each generation. While small loops may benefit from increased instruction-window sizes and large loops may see speedups via thread-level parallelism across cores, there remains unexploited parallelism at a medium granularity. The ParaSol project taps into this potential by bringing thread-level speculation schemes into the modern era. Our approach runs multiple loop iterations from a single thread in parallel within the microarchitecture. Compiler-inserted hints indicate where the core can spawn future loop iterations as new microarchitectural threadlets, which can leapfrog execution beyond the parent thread’s instruction window, exposing a new, medium-grained parallelism, orthogonal to traditional ILP and TLP. The hardware monitors data dependencies between executing threadlets, forwards data for true dependencies and squashes threadlets when ordering violations occur. Across a range of hard-to-parallelise workload created by the our compiler, we can achieve meaningful whole-program speedups with only modest area and power overheads.https://cassyni-user-files-prod.s3.amazonaws.com/JFgrphRUHb2xitqkGmoeBQ https://cassyni.com/events/TFxQ5DgTTLXe747omYpyqw/seminar/qa https://cassyni.com/slides/outline/TFxQ5DgTTLXe747omYpyqw https://cassyni.com/events/TFxQ5DgTTLXe747omYpyqw/abstract https://cassyni-user-files-prod.s3.amazonaws.com/kwHpFL3io56Z9vDubRfiW https://cassyni.com/events/TFxQ5DgTTLXe747omYpyqw?videoPreview=1 High Impact Research from Chinanohttps://cassyni.com/events/TFxQ5DgTTLXe747omYpyqw?videoPreview=12023-11-29T16:00:00+00:003559.24Topics at the heart of our communityChina has been increasing investment into research and development for the past two decades, and Clarivate’s data now shows that China produces the highest number of citable documents globally (nearly twice as many as the USA). However, what has been less apparent is the quality of those papers. This month, we explore the scientific culture and impact of research from China, and show that the impact is now at least comparable to the USA and Europe across several disciplines. https://cassyni-user-files-prod.s3.amazonaws.com/kwHpFL3io56Z9vDubRfiW https://cassyni.com/events/2ZYBm3LDWSqgwbq5FLEtAH/seminar/qa https://cassyni.com/slides/outline/2ZYBm3LDWSqgwbq5FLEtAH https://cassyni.com/events/2ZYBm3LDWSqgwbq5FLEtAH/abstract https://cassyni-user-files-prod.s3.amazonaws.com/SUqKXS5wH4TyBRjhJkVCZc https://cassyni.com/events/2ZYBm3LDWSqgwbq5FLEtAH?videoPreview=1 Roundtable on Black in cancer research and oncologynohttps://cassyni.com/events/2ZYBm3LDWSqgwbq5FLEtAH?videoPreview=12023-09-28T13:00:00+00:006119.0Research Seminars by Springer NatureThis webinar will focus on the challenges of Black researchers and patients within the cancer field. Doctors Fiyinfolu and Onyinye Balogun (perhaps better known as the Onc Docs) will be discussing the Black patient experience in endometrial cancer. Dr Brandon Blue will be speaking about his work in reducing disparities in the treatment of plasma cell dyscasias, and Dr Kilan Ashad-Bishop will be discussing her role in building STEMNoire, a research and wellness community dedicated to Black women in the STEM fields. Runcie Chidebe will discuss his work as the executive director of Project PINK BLUE, a non-profit organisation which provides cancer advocacy and oncology training in Nigeria. As part of the round table discussion, we will welcome questions from our audience regarding the challenges within the field, and potential means to improve inclusion within oncology. This webinar will be hosted by Nature Portfolio editors.https://cassyni-user-files-prod.s3.amazonaws.com/SUqKXS5wH4TyBRjhJkVCZc https://cassyni.com/slides/outline/aA7KnVWRSxGUfoaVcZSfo https://cassyni.com/events/aA7KnVWRSxGUfoaVcZSfo/abstract https://cassyni-user-files-prod.s3.amazonaws.com/6JjtTcT6jb1NJVyvoUih9Q https://cassyni.com/events/aA7KnVWRSxGUfoaVcZSfo?videoPreview=1 Linear predictions of secondary flows over modulated wallsnohttps://cassyni.com/events/aA7KnVWRSxGUfoaVcZSfo?videoPreview=12023-03-08T16:00:00+00:002243.4Department of AeronauticsWhen a wall-bounded turbulent flow develops over a surface with heterogeneous attributes, for example with spanwise variations of the topography or of the roughness properties, secondary currents emerge in the form of time-averaged, streamwise-aligned vortices. These flows have been studied in great detail in the last 10 years, but several open questions remain. For instance, one key question is the role of the spanwise length scale over which variations of the surface properties occur and what mechanisms produce more intense secondary currents when such length scale is of the same order of the boundary layer thickness. The talk will present recent modelling work done at the University of Southampton to answer these questions. Linearised Reynolds-Averaged Navier-Stokes equations are introduced as a rapid predictive tool to explore the parameter space characterising heterogeneous surfaces and study the time-average response of the shear flow. The talk will focus on the derivation of the mathematical model, including the transport model for the eddy viscosity, the nonlinear Reynolds stress-strain model as well as linearised boundary conditions. Applications of this tool to turbulent channels with sinusoidal walls and with rectangular longitudinal ribs will be discussed.https://cassyni-user-files-prod.s3.amazonaws.com/6JjtTcT6jb1NJVyvoUih9Q https://cassyni.com/slides/outline/JNEH1f1EkNi6yUVafBqBb3 https://cassyni.com/events/JNEH1f1EkNi6yUVafBqBb3/abstract https://cassyni-user-files-prod.s3.amazonaws.com/PkZvBHhnW5GP9SsSo4nvXg https://cassyni.com/events/JNEH1f1EkNi6yUVafBqBb3?videoPreview=1 Deep Learning for Turbulence Closure Modelingnohttps://cassyni.com/events/JNEH1f1EkNi6yUVafBqBb3?videoPreview=12021-05-14T12:00:00+00:001347.84Brunton LabMachine learning, and in particular deep neural networks, are currently revolutionizing how we model turbulent fluid dynamics. This video describes how deep learning is being used for turbulence closure modeling, especially for the Reynolds averaged Navier Stokes (RANS) equations and large eddy simulations (LES).https://cassyni-user-files-prod.s3.amazonaws.com/PkZvBHhnW5GP9SsSo4nvXg https://cassyni.com/events/Jrst4LemBqG9yF2UFd7yrM/seminar/qa https://cassyni.com/slides/outline/Jrst4LemBqG9yF2UFd7yrM https://cassyni.com/events/Jrst4LemBqG9yF2UFd7yrM/abstract https://cassyni-user-files-prod.s3.amazonaws.com/WUELBzXYKH5eJPPvvfqqRp https://cassyni.com/events/Jrst4LemBqG9yF2UFd7yrM?videoPreview=1 GPU-Accelerated High-Fidelity Implicit LES of Coanda Cylinder Flow Instabilitiesnohttps://cassyni.com/events/Jrst4LemBqG9yF2UFd7yrM?videoPreview=12023-03-02T15:00:00+00:002318.2PyFRThis work covers multiple 3D Implicit Large Eddy Simulations covering two cases: The quiescent Coanda cylinder and the Coanda cylinder in a freestream. Previous works have shown RANS is insufficient in resolving Coanda jets, thus requiring higher fidelity tools. PyFR was chosen due to its demonstrated efficiency in running parallel computations on multiple GPUs. For the quiescent case we aim to capture unsteady flow structures observed experimentally around a Coanda cylinder placed in a water tank. Using dyes, image processing and PIV measurements, these experiments were able to capture streamwise counter-rotating vortices (Gortler instabilities) as well as some initial transient structures of interest. Due to the incompressible nature of the experimental setup the case was simulated using PyFR's artificial compressibility solver, making use of the acceleration capabilities available in dual time stepping and the synthetic turbulence generation capabilities of PyFR. In the case of the Coanda cylinder in a freestream our goal is to simulate the CoRe system (Coanda Reciprocating), a wind energy harvesting method involving the creation of reciprocating lift force on a cylinder by alternate blowing of air through opposing slots on a cylinder perpendicular to the wind direction. For the second case simulations were performed using PyFR's compressible solver due to the local Mach number crossing into the incompressible range. Simulations of the quiescent case were able to qualitatively capture both the counter rotating structures and the initial transients, though quantitative comparison of vorticity magnitude and vortex structure size shows a discrepancy from the experimental measurements. For the freestream case simulations were able to accurately capture the time averaged pressure distribution on the cylinder for momentum coefficients above 0.06, as well as the alternating lift force, though a large deviation in the drag force prediction was observed. https://cassyni-user-files-prod.s3.amazonaws.com/WUELBzXYKH5eJPPvvfqqRp https://cassyni.com/events/VEVa2hEnQStaVkKcGj4sXs/abstract https://cassyni-user-files-prod.s3.amazonaws.com/3BJyn5uNH8HExkX7YskMci https://cassyni.com/slides/outline/RmxLhui7LF1wU423d4gv13 https://cassyni.com/events/RmxLhui7LF1wU423d4gv13/abstract https://cassyni-user-files-prod.s3.amazonaws.com/W5xhCrN5i5jDxaWCWTHQ4v https://cassyni.com/events/RmxLhui7LF1wU423d4gv13?videoPreview=1 Nature Water Talks - Our February highlights: Decentralized water treatment technologies and groundwater arsenic contaminationnohttps://cassyni.com/events/RmxLhui7LF1wU423d4gv13?videoPreview=12023-03-07T13:00:00+00:004275.64Nature WaterFabio Pulizzi will host Nadja Contzen to discuss her work on the importance of user acceptance for the implementation of decentralized water treatment technologies. Yanhua Chen will then talk to Benjamin Bostick about factors that impact arsenic contamination of groundwater. Read the articles here: 1. <https://rdcu.be/c53DH> 2. <https://rdcu.be/c53DL> https://cassyni-user-files-prod.s3.amazonaws.com/W5xhCrN5i5jDxaWCWTHQ4v https://cassyni.com/events/UFCMwKwjXXnRpzVcAkbYiy/seminar/qa https://cassyni.com/slides/outline/UFCMwKwjXXnRpzVcAkbYiy https://cassyni.com/events/UFCMwKwjXXnRpzVcAkbYiy/abstract https://cassyni-user-files-prod.s3.amazonaws.com/FLuHvaFTYd5Yc1shTMFc9t https://cassyni.com/events/UFCMwKwjXXnRpzVcAkbYiy?videoPreview=1 Cost behaviour and reporting frequency during the COVID-19 outbreaknohttps://cassyni.com/events/UFCMwKwjXXnRpzVcAkbYiy?videoPreview=12023-05-04T23:00:00+00:003555.76SACLThis paper examines the effect of financial reporting frequency on cost management decisions during the COVID-19 outbreak in the first half of 2020, when firms had to make broad changes to their cost structures. Using the European setting, we find that quarterly reporters had more elastic cost structures relative to semi-annual reporters, meaning they had a larger change in cost for each change in sales. These differences existed already before the pandemic but became more pronounced during the crisis, consistent with our predictions based on managerial learning and monitoring pressure. When allowing for cost asymmetry, we find that our results are mainly driven by firms with decreases in sales and that quarterly reporters had anti-sticky costs. Our results are also stronger in highly affected industries. Further, we find that analysts updated their forecasts more frequently for quarterly reporters. Additional analyses also show higher cumulative abnormal returns around half-year earnings announcements and superior firm performance following the outbreak among quarterly reporters, potentially due to greater cost elasticity. With this study, we contribute to the literature on cost behaviour, reporting frequency, and to the emerging stream of accounting and finance studies on the COVID-19 pandemic.https://cassyni-user-files-prod.s3.amazonaws.com/FLuHvaFTYd5Yc1shTMFc9t https://cassyni.com/slides/outline/ER3SeBq3EiGxBp2uG5F8z9 https://cassyni.com/events/ER3SeBq3EiGxBp2uG5F8z9/abstract https://cassyni-user-files-prod.s3.amazonaws.com/L4HzZzmyu63h7gP5cCQU3x https://cassyni.com/events/ER3SeBq3EiGxBp2uG5F8z9?videoPreview=1 Anthromes, CO2 and Terrestrial Carbon – Session 2 (part 2): CO2 and land use change as drivers of terrestrial carbon dynamicsnohttps://cassyni.com/events/ER3SeBq3EiGxBp2uG5F8z9?videoPreview=12023-03-28T18:00:00+00:002516.44The New Phytologist Foundation2.00 – 2.20: The Amazon as a showcase on the interplay between CO2 effects, LUC and carbon dynamics , David Lapola 2.20 – 2.40: Contributions of CO 2 -fertilization and deforestation to future climate and carbon storage change in the Amazon, Yue Li https://cassyni-user-files-prod.s3.amazonaws.com/L4HzZzmyu63h7gP5cCQU3x https://cassyni.com/slides/outline/9UZQBMMnr8jvniKZFbY9G1 https://cassyni.com/events/9UZQBMMnr8jvniKZFbY9G1/abstract https://cassyni-user-files-prod.s3.amazonaws.com/VKrjZimK37Gn1pbTSFQpsQ https://cassyni.com/events/9UZQBMMnr8jvniKZFbY9G1?videoPreview=1 Survival after resection of brain metastasis: impact of synchronous versus metachronous metastatic diseasenohttps://cassyni.com/events/9UZQBMMnr8jvniKZFbY9G1?videoPreview=12023-04-03T20:00:00+00:001308.28Journal of Neuro-OncologyJoin Dr. Randy D'Amico & Dr. Jason Sheehan of the Journal of Neuro-Oncology for a discussion with Dr. med Anna-Laura Potthoff and Dr. med Matthias Schneider from the University Hospital Bonn to discuss their latest journal article on the survival after resection of brain metastasis & the impact of synchronous versus metachronous metastatic disease.https://cassyni-user-files-prod.s3.amazonaws.com/VKrjZimK37Gn1pbTSFQpsQ https://cassyni.com/slides/outline/Mpo8T53oDwWWpsFmWX3K2m https://cassyni.com/events/Mpo8T53oDwWWpsFmWX3K2m/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Mkmj5UxaRjDkA8PAKwXepv https://cassyni.com/events/Mpo8T53oDwWWpsFmWX3K2m?videoPreview=1 Phase Transitions in Evolutionary and Population Dynamicsnohttps://cassyni.com/events/Mpo8T53oDwWWpsFmWX3K2m?videoPreview=12021-09-30T09:00:00+00:003765.44Journal of Biological PhysicsUnderstanding the mechanisms of population collapse and evolutionary dynamics are critically important both for rescuing at-risk species as climate change accelerates, and for mapping the underlying patterns of evolutionary history. Studies of bacterial population collapse also have important implications for the increasing problem of antibiotic resistance. I will discuss applications of the statistical physics of nonequilibrium phase transitions (1) to computational models of evolutionary dynamics and (2) in experimental studies of microbial populations. In the computational studies, we find that simulated populations undergo a phase transition from survival to extinction as various control parameters are varied. This transition has some characteristics of directed percolation, but does not completely fall into that universality class. Experimentally, we find that microbial populations respond to some stressors with phase-transition-like collapse, and to other stressors with more graduate decline. Yeast cells (S. cerevisiae), for example, exhibit phase-transition-like behavior in the presence of heat stress, but a gradual decline in the presence of salt stress. Surprisingly, bacterial (E. coli) populations show such differential responses even to antibiotics with similar mechanisms of action.https://cassyni-user-files-prod.s3.amazonaws.com/Mkmj5UxaRjDkA8PAKwXepv https://cassyni.com/events/GtK5zEaYqMyVRmYRW3LKJd/seminar/qa https://cassyni.com/slides/outline/GtK5zEaYqMyVRmYRW3LKJd https://cassyni.com/events/GtK5zEaYqMyVRmYRW3LKJd/abstract https://cassyni-user-files-prod.s3.amazonaws.com/7oswdd1E6erJ3FnM9Ru7tS https://cassyni.com/events/GtK5zEaYqMyVRmYRW3LKJd?videoPreview=1 How Your Journal Can Support and Amplify the Sustainable Development Goalsnohttps://cassyni.com/events/GtK5zEaYqMyVRmYRW3LKJd?videoPreview=12023-06-29T12:45:00+00:002226.8Topics at the heart of our communityBuilding on the success of [last year's event](https://www.springernature.com/gp/advancing-discovery/spotlight-on), join us this June to learn more about Springer Nature’s Sustainable Development Goal (SDG) Programme and how journals are supporting and amplifying the SDGs. https://cassyni-user-files-prod.s3.amazonaws.com/7oswdd1E6erJ3FnM9Ru7tS https://cassyni.com/events/SmHAuuX3cX3pHHYT1c6gSZ/seminar/qa https://cassyni.com/slides/outline/SmHAuuX3cX3pHHYT1c6gSZ https://cassyni.com/events/SmHAuuX3cX3pHHYT1c6gSZ/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Jy38fEqweReeQr5bB8gzUv https://cassyni.com/events/SmHAuuX3cX3pHHYT1c6gSZ?videoPreview=1 Navigating Spacecraft Through the Giant Planets (and a Few Other Space Mission Ideas)nohttps://cassyni.com/events/SmHAuuX3cX3pHHYT1c6gSZ?videoPreview=12023-06-14T16:00:00+00:003428.84Department of AeronauticsWhat does it take to fly a spacecraft through the rings of Saturn, through the plumes of Enceladus, or through Jupiter and the icy surface of Europa? In this talk you will hear about these and other deep space mission concepts. You will understand what it takes to design a trajectory for a spacecraft to get to these far worlds, and how to accurately navigate a spacecraft in deep space. https://cassyni-user-files-prod.s3.amazonaws.com/Jy38fEqweReeQr5bB8gzUv https://cassyni.com/slides/outline/24rxbjAofdMs7qFiVPWaku https://cassyni.com/events/24rxbjAofdMs7qFiVPWaku/abstract https://cassyni-user-files-prod.s3.amazonaws.com/CsdhX7GP7mMPE3SuiedtZc https://cassyni.com/events/24rxbjAofdMs7qFiVPWaku?videoPreview=1 Te Awa Tupua—ko te Awa te tuatahi, ko te Awa te tuaruanohttps://cassyni.com/events/24rxbjAofdMs7qFiVPWaku?videoPreview=12023-05-03T12:00:00+00:003484.68Stout Research Centre for New Zealand StudiesIn 2017 for the first time in Aotearoa New Zealand a river was granted legal recognition. This recognition included a set of values, Tupua Te Kawa which now guide the way in which decisions are made across the Whanganui River catchment. For this reason, Te Awa Tupua (the Whanganui River Claim Settlement) provides one of the most striking departures in water governance this century in recent history. In this seminar, Nancy will talk about Te Awa Tupua and what we can learn from its approach.https://cassyni-user-files-prod.s3.amazonaws.com/CsdhX7GP7mMPE3SuiedtZc https://cassyni.com/slides/outline/Bwq3XQ7JSnSByMFjzxGwtq https://cassyni.com/events/Bwq3XQ7JSnSByMFjzxGwtq/abstract https://cassyni-user-files-prod.s3.amazonaws.com/5EJMfzTLwmnw9wZ8nxLHK4 https://cassyni.com/events/Bwq3XQ7JSnSByMFjzxGwtq?videoPreview=1 Limits on Energy and Angular Momentum for Escape and Collapse in the Full N-Body Problemnohttps://cassyni.com/events/Bwq3XQ7JSnSByMFjzxGwtq?videoPreview=12022-09-05T09:30:00+00:002334.28Celestial Mechanics and Dynamical AstronomyThe range of energies and angular momentum that exist for the full N-Body problem when components are resting on each other is studied. Using a simple model of equal sized spheres, lower and upper bounds on a system?s energy are found for the collection to remain connected as a single body, when fission into multiple components will occur, and what the implications are when individual components escape from the system.https://cassyni-user-files-prod.s3.amazonaws.com/5EJMfzTLwmnw9wZ8nxLHK4 https://cassyni.com/slides/outline/HNzK9YjxgBTKFY7nFz4ci1 https://cassyni.com/events/HNzK9YjxgBTKFY7nFz4ci1/abstract https://cassyni-user-files-prod.s3.amazonaws.com/TNviMhY9EsGxfpNnirHKmp https://cassyni.com/events/HNzK9YjxgBTKFY7nFz4ci1?videoPreview=1 Defocusing PTV applied to an open wet clutchnohttps://cassyni.com/events/HNzK9YjxgBTKFY7nFz4ci1?videoPreview=12023-10-24T14:00:00+00:002957.24Experiments in FluidsThe optical measurement technique Defocusing Particle Tracking Velocimetry (Defocusing PTV) is applied to the sub-millimeter gap of an open wet clutch to gain deeper insights into the unknown flow, which causes a significant loss in nowadays automobiles. The present work improves the fundamental understanding of the flow and its contribution to the generated drag torque and the physical process of aeration. A set of governing analytical equations is revealed from in-depth theoretical considerations, which describe the general cause-effect relations of the flow. To gain deeper insights into the unknown intra-groove phenomena Defocusing PTV is successfully applied to (locally) extract precise vortex information and fine resolved wall shear stress values. Metrological insights are generated with the introduction of a new detection strategy and the proven flexibility of Defocusing PTV, which makes comprehensive magnification and location-accuracy studies possible. The work is completed with a flow analysis along the entire radial region of interest, and the consideration of a more complex groove geometry.https://cassyni-user-files-prod.s3.amazonaws.com/TNviMhY9EsGxfpNnirHKmp https://cassyni.com/slides/outline/VjCRJdv5edJB9DMbELdLr9 https://cassyni.com/events/VjCRJdv5edJB9DMbELdLr9/abstract https://cassyni-user-files-prod.s3.amazonaws.com/3VKDe7yQn4qA3Wjzid43yG https://cassyni.com/events/VjCRJdv5edJB9DMbELdLr9?videoPreview=1 Discovering gedy's of precursory failure in motion datanohttps://cassyni.com/events/VjCRJdv5edJB9DMbELdLr9?videoPreview=12022-06-20T12:00:00+00:003495.08Granular MatterAdvancing the basic science of granular failure is challenging, but so is translating these advances from the lab to the field. In Yoda's words, "Difficult to see; always in motion is the future." Could motion be the key? After all, what is measured in the field is motion (or deformation), not stress. Here we share lessons learned from data-driven characterization and modelling of failure across space and time scales from motion data. Attention will be paid to the common intrinsic structure of such data - across different spatial scales - be it formed by individual grain movements in a lab test or by ground motion in the field. We coined this generic dynamics "gedy’s". With the support of partners (e.g., industry and International Consortium on Landslides), we briefly discuss examples of gedy's in some catastrophic landslides and how they can be exploited in applications of AI in practical landslide risk assessment and decision-making.https://cassyni-user-files-prod.s3.amazonaws.com/3VKDe7yQn4qA3Wjzid43yG https://cassyni.com/slides/outline/7zfqGZSzLUvmLU5JrFEg9j https://cassyni.com/events/7zfqGZSzLUvmLU5JrFEg9j/abstract https://cassyni-user-files-prod.s3.amazonaws.com/BHA99Uas7YoKc9ExH2Ajux https://cassyni.com/events/7zfqGZSzLUvmLU5JrFEg9j?videoPreview=1 Images, Videos & Personal Informationnohttps://cassyni.com/events/7zfqGZSzLUvmLU5JrFEg9j?videoPreview=12021-12-02T12:30:00+00:003656.16Journal on Image and Video ProcessingNo abstracthttps://cassyni-user-files-prod.s3.amazonaws.com/BHA99Uas7YoKc9ExH2Ajux https://cassyni.com/events/DRoUn5ZmAX2ATsf6rsUa77/seminar/qa https://cassyni.com/slides/outline/DRoUn5ZmAX2ATsf6rsUa77 https://cassyni.com/events/DRoUn5ZmAX2ATsf6rsUa77/abstract https://cassyni-user-files-prod.s3.amazonaws.com/XuD9wxHnEMYRdn9tu8QE3G https://cassyni.com/events/DRoUn5ZmAX2ATsf6rsUa77?videoPreview=1 HiPerDiF: A New Route to Produce Sustainable Compositesnohttps://cassyni.com/events/DRoUn5ZmAX2ATsf6rsUa77?videoPreview=12023-11-08T16:00:00+00:004603.72Department of AeronauticsThe High Performance Discontinuous Fibre (HiPerDiF) technology is now entering its 13th year. Originally developed at Bristol within the EPSRC-funded HiPerDuCT programme grant, and subsequently patented, the method offers a more sustainable route to the production of advanced composites. An upscaled machine, owned by the University of Bristol and based in the National Composites Centre, also makes it possible to generate novel prepreg material (25 mm wide) at scales (ca. 30-50 m/run) that allow the production of larger laminates for standard mechanical tests to be performed. This has led to the launch of a spin out company (Lineat Composites Ltd.) in 2021. In this presentation, Prof. Hamerton will describe the history of the technique and concentrate on more recent developments in a variety of current research projects within the Bristol Composites Institute. Check out these links: [1](https://www.compositesworld.com/articles/going-discontinuous-for-continuous-improvement) and [2](https://www.compositesworld.com/articles/high-performance-sustainability-and-cost-efficiency-advance-with-hiperdif). https://cassyni-user-files-prod.s3.amazonaws.com/XuD9wxHnEMYRdn9tu8QE3G https://cassyni.com/slides/outline/CSWGgiGiHbv1o7q6ku1FJD https://cassyni.com/events/CSWGgiGiHbv1o7q6ku1FJD/abstract https://cassyni-user-files-prod.s3.amazonaws.com/THs234zXz37C5UvyPLJZTc https://cassyni.com/events/CSWGgiGiHbv1o7q6ku1FJD?videoPreview=1 Web-Numerical Simulation of Vertical Axis Turbines for Hydrokinetic Applicationsnohttps://cassyni.com/events/CSWGgiGiHbv1o7q6ku1FJD?videoPreview=12021-12-13T11:30:00+00:003713.8Discover Applied SciencesThe application of Computational Fluid Dynamics (CFD) to energy-related problems has increased in the last decades in both renewable and conventional energy conversion processes. In recent years, the application of CFD in the study of hydraulic, marine, tidal, and hydrokinetic turbines has focused on the understanding of the details of the complex turbulent flow and also in improving the prediction of the performance of these devices. There are several complexities involved in the simulation of Vertical Axis Turbine (VAT) for hydrokinetic applications. One of them is the necessity of a dynamic mesh model. Typically, the model used in the simulation of these devices is the sliding mesh technique, but in recent years the fast development of the overset (also known as chimera) mesh technique has caught the attention of the academic community. In the present paper, a comparison between these two techniques is done in order to establish their advantages and disadvantages in the two-dimensional simulation of vertical axis turbines. The comparison was done not only for the prediction of performance parameters of the turbine but also for the capabilities of the models to capture complex flow phenomena in these devices and computational costs.https://cassyni-user-files-prod.s3.amazonaws.com/THs234zXz37C5UvyPLJZTc https://cassyni.com/events/LqZAaxnX9kFj6vsy7KGk9j/abstract https://cassyni-user-files-prod.s3.amazonaws.com/M65mf9ED8VVgAxJczRYPL2 https://cassyni.com/events/ATwUccCVw8dMFeM41KDakV/seminar/qa https://cassyni.com/slides/outline/ATwUccCVw8dMFeM41KDakV https://cassyni.com/events/ATwUccCVw8dMFeM41KDakV/abstract https://cassyni-user-files-prod.s3.amazonaws.com/3gp8zCUTxq3a163DsMWCTg https://cassyni.com/events/ATwUccCVw8dMFeM41KDakV?videoPreview=1 Presentation of EAJ Issue 13/2 - December 11thnohttps://cassyni.com/events/ATwUccCVw8dMFeM41KDakV?videoPreview=12023-12-11T16:00:00+00:004455.08European Actuarial JournalThe seminar is chaired by Torsten Kleinow and Griselda Deelstra.https://cassyni-user-files-prod.s3.amazonaws.com/3gp8zCUTxq3a163DsMWCTg https://cassyni.com/slides/outline/KrFxVbVUGq9aSB3y1LoRLq https://cassyni.com/events/KrFxVbVUGq9aSB3y1LoRLq/abstract https://cassyni-user-files-prod.s3.amazonaws.com/E8RsfuU2RWdi1vfRjyb9wt https://cassyni.com/events/KrFxVbVUGq9aSB3y1LoRLq?videoPreview=1 Introducing Transformative Plant Biotechnology: Building a molecular toolkit to understand Begonia evolutionnohttps://cassyni.com/events/KrFxVbVUGq9aSB3y1LoRLq?videoPreview=12023-09-21T09:00:00+00:001032.32The New Phytologist FoundationWith a pantropical distribution and over 2000 described species, Begonia is an understudied angiosperm genera. In particular, high diversity and multiple whole-genome duplication events make Begonia an excellent model to investigate the fates of duplicated genes and how evolution has modified gene function in different paralogs and different lineages. Sequence analysis reveals high level of copy number variation and variation in conserved regions of key leaf development genes. To discover the impact of theses changes on function we need to establish genetic engineering techniques in Begonia. We have created a pipeline to establish shoot regeneration through tissue culture in any Begonia species, which we are extending to establish stable transformation. We have also developed a transient transformation protocol to use for molecular subcellular localisation assays.https://cassyni-user-files-prod.s3.amazonaws.com/E8RsfuU2RWdi1vfRjyb9wt https://cassyni.com/slides/outline/RHPc17cF6sEyZadm1y3KJD https://cassyni.com/events/RHPc17cF6sEyZadm1y3KJD/abstract https://cassyni-user-files-prod.s3.amazonaws.com/PggPPkF1TLzbp5svNq2egE https://cassyni.com/events/RHPc17cF6sEyZadm1y3KJD?videoPreview=1 Coding bacterial genetic information into structural attributesnohttps://cassyni.com/events/RHPc17cF6sEyZadm1y3KJD?videoPreview=12021-10-25T12:00:00+00:003324.04Discover Applied SciencesThe gene transcription of bacteria starts with a promoter sequence being recognized by a transcription factor found in the RNAP enzyme, this process is assisted through the conservation of nucleotides as well as other factors governing these intergenic regions. Faced with this, the coding of genetic information into physical aspects of the DNA such as enthalpy, stability, and base-pair stacking could suggest promoter activity as well as protrude differentiation of promoter and non-promoter data. In this work, a total of 3131 promoter sequences associated to six different sigma factors in the bacterium E. coli were converted into numeric attributes, a strong set of control sequences referring to a shuffled version of the original sequences as well as coding regions is provided. Then, the parameterized genetic information was normalized, exhaustively analyzed through statistical tests. The results suggest that strong signals in the promoter sequences match the binding site of transcription factor proteins, indicating that promoter activity is well represented by its conversion into physical attributes. Moreover, the features tested in this report conveyed significant variances between promoter and control data, enabling these features to be employed in bacterial promoter classification. The results produced here may aid in bacterial promoter recognition by providing a robust set of biological inferences.https://cassyni-user-files-prod.s3.amazonaws.com/PggPPkF1TLzbp5svNq2egE https://cassyni.com/events/8VM4RscQBJQb9w4peMMeKw/seminar/qa https://cassyni.com/slides/outline/8VM4RscQBJQb9w4peMMeKw https://cassyni.com/events/8VM4RscQBJQb9w4peMMeKw/abstract https://cassyni-user-files-prod.s3.amazonaws.com/TPRLE1nJQGqfQDHdDB6ow4 https://cassyni.com/events/8VM4RscQBJQb9w4peMMeKw?videoPreview=1 Accounting for Carbonnohttps://cassyni.com/events/8VM4RscQBJQb9w4peMMeKw?videoPreview=12023-11-23T22:00:00+00:005338.64SACLThe paper designs an accounting for carbon that reports an entity’s net carbon contribution to society. The accounting is in the same form as financial accounting, reporting a balance sheet and an income statement. In the balance sheet, assets in reducing carbon are compared to liabilities for carbon admissions, reporting an entity’s net position in carbon, with the accumulated difference reporting its progress over time in reaching goals such as a net-zero carbon promise. With a balance sheet, the accounting provides more information than the standard flow number, the current period’s net emissions. By recognizing assets, an entity gets credit for current efforts to reduce carbon that are realized only later, thus dealing with the timing problem between investing in carbon removal and its effect. The accounting is a responsibility accounting that has many attractive reporting and incentive features and enables a pro forma analysis for evaluating carbon strategies. Like financial accounting, it facilitates consolidation accounting across groups such as industries or divisions within firms. It leads to an analysis like financial statement analysis that gets to the drivers of net emissions. Being in the form of financial accounting, it facilitates comparisons with financial metrics to evaluate trade-offs and “sustainability" more generally.https://cassyni-user-files-prod.s3.amazonaws.com/TPRLE1nJQGqfQDHdDB6ow4 https://cassyni.com/events/Fu5888KGmAiReWbHcEDNjw/seminar/qa https://cassyni.com/slides/outline/Fu5888KGmAiReWbHcEDNjw https://cassyni.com/events/Fu5888KGmAiReWbHcEDNjw/abstract https://cassyni-user-files-prod.s3.amazonaws.com/4rD7yX4ebX4NufSE94ZL14 https://cassyni.com/slides/outline/Axb5fHr2NbBQFQswbkWP1o https://cassyni.com/events/Axb5fHr2NbBQFQswbkWP1o/abstract https://cassyni-user-files-prod.s3.amazonaws.com/J1kmuAp7huj5uipWggcaE2 https://cassyni.com/events/Axb5fHr2NbBQFQswbkWP1o?videoPreview=1 Bayesian Aerothermal Interpolationnohttps://cassyni.com/events/Axb5fHr2NbBQFQswbkWP1o?videoPreview=12021-04-21T14:00:00+00:001075.32Leeds Institute for Fluid DynamicsBayesian aerothermal interpolation is the statistics and physics of inferring aerothermal quantities given few measurements. The 'Bayesian' perspective arises from both uncertainties in the measurements and uncertainties between measurements. It is in the latter that we need to carefully prescribe correlations between different physical quantities. This can be done by embedding a hierarchy of modelling assumptions within this correlation (a kernel), ranging from a loose assumption of spatial smoothness to conservation laws, or judgement, i.e., the variation in temperature between any two points is governed by some harmonic forcing. With an appropriate parameterisation of such a kernel function – which may be underscored by certain priors – Bayesian inference can be used to arrive at a posterior distribution, given a few measurements and uncertainties thereof. In this talk, I will share two Bayesian aerothermal interpolation case studies. The first is the measurement of jet-engine sub-system (fans, compressors, turbines, etc.) efficiencies, where the measurements are sparsely placed pressure and temperature rakes. The second case study is the quantification of density from old Schlieren images, where the sensors are densely sampled pixels that measure the refractive index gradient field.https://cassyni-user-files-prod.s3.amazonaws.com/J1kmuAp7huj5uipWggcaE2 https://cassyni.com/slides/outline/MLEPkGwvzZjYvPsUuRPiKw https://cassyni.com/events/MLEPkGwvzZjYvPsUuRPiKw/abstract https://cassyni-user-files-prod.s3.amazonaws.com/HtbNdzuEbYb4VUVjZJKSb8 https://cassyni.com/events/MLEPkGwvzZjYvPsUuRPiKw?videoPreview=1 Aspects of MHD wave heating in the complex solar atmospherenohttps://cassyni.com/events/MLEPkGwvzZjYvPsUuRPiKw?videoPreview=12022-03-10T12:00:00+00:003043.88Leeds Institute for Fluid DynamicsNo abstracthttps://cassyni-user-files-prod.s3.amazonaws.com/HtbNdzuEbYb4VUVjZJKSb8 https://cassyni.com/slides/outline/UjxTSXeoaS3PQyPwsJFSjw https://cassyni.com/events/UjxTSXeoaS3PQyPwsJFSjw/abstract https://cassyni-user-files-prod.s3.amazonaws.com/K176W213pbGoA6un9eMQ46 https://cassyni.com/events/UjxTSXeoaS3PQyPwsJFSjw?videoPreview=1 Liquid interface and buoyancy stabilization using high-frequency vibrationsnohttps://cassyni.com/events/UjxTSXeoaS3PQyPwsJFSjw?videoPreview=12022-10-21T12:00:00+00:003505.44UK Fluids NetworkUnder standard experimental conditions, a liquid layer placed above an air layer (e.g. painting on a ceiling) tends to fall due to gravity. However, it was demonstrated a few decades ago that vertical high-frequency vibrations can prevent the liquid’s fall. In the first part of the seminar, I will discuss such phenomenon as well as other unexpected phenomena due to high-frequency vibrations in fluids. In particular, I will show that the vibrations allow inverted buoyancy of small objects at the lower interface of the liquid. In the second part, I will discuss the case of non-vertical vibrations. As a result, non-horizontal liquid interfaces can be stabilized in so-called 'vibro-equilibria'. As for the case of vertical vibrations, floating objects behave as if gravity was directed orthogonally to the liquid’s interface. To conclude, I will show how vibrations and bubbles can be used to deform liquids in arbitrary manners, as well as transport phenomena at such interfaces.https://cassyni-user-files-prod.s3.amazonaws.com/K176W213pbGoA6un9eMQ46 https://cassyni.com/slides/outline/TkfFMAMkhWwEkDZwmKn7w3 https://cassyni.com/events/TkfFMAMkhWwEkDZwmKn7w3/abstract https://cassyni-user-files-prod.s3.amazonaws.com/2JNzjVmHe1NEMV92DLGDfC https://cassyni.com/events/TkfFMAMkhWwEkDZwmKn7w3?videoPreview=1 Multimode multiple scattering in disordered systems of spherical scatterersnohttps://cassyni.com/events/TkfFMAMkhWwEkDZwmKn7w3?videoPreview=12024-02-13T14:00:00+00:003599.08MetaMATWe will consider the propagation of ultrasound in nano/microparticle suspensions consisting of disordered (randomly distributed) solid particles in a viscous liquid or other soft viscoelastic material. Understanding the complex wave propagation in such systems is important, both from the point of view of characterising soft materials – for biological tissues, or for industrial process monitoring e.g. in pharma and food – and for the design of metamaterials where enhanced absorption may be desirable – for example for stealth coatings. An important and interesting characteristic of these systems is the existence of two wavenumbers of very different magnitudes in the continuous phase – for the compressional and shear modes. For typical liquids at MHz frequencies, and with colloidal particles, the dimensionless compressional wavenumber (based on particle size) may be small whereas the dimensionless shear wavenumber can range from small to large and is always much larger than the dimensionless compressional wavenumber. In addition, we have another length scale that affects the multiple scattering, i.e. the interparticle separation; its effects are usually accounted for through the concentration or number density but it may be helpful to consider these effects in terms of additional dimensionless wavenumbers relating to the interparticle distance. Recently, a new formulation for the effective wavenumber arising from multiple scattering in a multi-mode media was published (Luppe, Conoir & Valier-Brasier, Wave Motion 115 (2022) 103082). In this presentation, we will show analytical asymptotic results obtained from the model at long compressional wavelength (low frequency), but arbitrary shear wavelength for these soft media, highlighting the dominant wave-conversion and correlation contributions. We will show numerical results to validate the approximations made for this system and compare with experimental data. Although it is common to consider that structure has minimal effect at long wavelength, in these dual-wave-mode systems the particle correlations are seen to have a significant effect because of the influence of the small shear wavelength. https://cassyni-user-files-prod.s3.amazonaws.com/2JNzjVmHe1NEMV92DLGDfC https://cassyni.com/slides/outline/6WnGMmYBpq7vcTamtmZynD https://cassyni.com/events/6WnGMmYBpq7vcTamtmZynD/abstract https://cassyni-user-files-prod.s3.amazonaws.com/7mC6cdcJKoUDCppbY38Tdx https://cassyni.com/events/6WnGMmYBpq7vcTamtmZynD?videoPreview=1 Utilizing Multiple Strategies to Advance Equitable Implementation of Lung Cancer Screening: Implications of Varying Eligibility Criteria by Race and Ethnicitynohttps://cassyni.com/events/6WnGMmYBpq7vcTamtmZynD?videoPreview=12023-05-18T14:00:00+00:003203.4Center for Cancer TrainingIn 2013, lung cancer screening (lung screening) was recommended for high-risk individuals. The annual rate of lung screening has risen slowly, particularly among Black individuals. In part, this racial disparity resulted in expanded 2021 screening criteria. Methods: Survey data were used to: 1) describe the number of people screened in 2019, 2) compare the percent eligible for lung screening using the 2013 versus the 2021 guidelines, and 3) determine the percent eligible using more detailed criteria. Results: Lung screening rates increased in 2019, and the 2021 criteria will result in more individuals eligible for screening. Using additional criteria may identify more individuals eligible for lung screening. Conclusions: This presentation will discuss ways to include more individuals who may benefit from lung screening and other strategies that can improve screening rates in an equitable mannerhttps://cassyni-user-files-prod.s3.amazonaws.com/7mC6cdcJKoUDCppbY38Tdx https://cassyni.com/events/aJDtw4wSFauDMsRtHrz45/seminar/qa https://cassyni.com/slides/outline/aJDtw4wSFauDMsRtHrz45 https://cassyni.com/events/aJDtw4wSFauDMsRtHrz45/abstract https://cassyni-user-files-prod.s3.amazonaws.com/AZGLL9NHPEYqC8DtnAHKhQ https://cassyni.com/events/aJDtw4wSFauDMsRtHrz45?videoPreview=1 Introduction to the 6th Biometals Webinars, Mechanistic studies of the bacterial nitrosative stress sensor NsrRnohttps://cassyni.com/events/aJDtw4wSFauDMsRtHrz45?videoPreview=12024-07-02T13:00:00+00:003940.08BioMetalsNitric oxide (NO) is a ubiquitous signalling molecule and cytotoxic agent. In order to survive and thrive, organisms must be able to respond to NO, and the regulatory protein NsrR, a member of the Rrf2 protein superfamily, plays a major role in this as it is found in a wide range of benign and pathogenic bacteria. NsrR binds a [4Fe-4S] cluster as a cofactor and, in the absence of NO, represses transcription of genes primarily involved NO detoxification. Previously, we have shown that [4Fe-4S] NsrR reacts rapidly with NO, in a complex reaction involving multiple NO molecules per cluster, resulting in formation of NsrR-bound iron-nitrosyl species [3]. Here, we sought to investigate the reaction of [4Fe-4S] NsrR bound to DNA, in order to determine when high affinity DNA-binding is lost. Using surface plasmon resonance (SPR) and native mass spectrometry (MS) NsrR binding to the promoter regions of two NsrR-regulated genes, hmpA1 and hmpA2 was probed, revealing the nature of binding and the reaction of DNA-bound NsrR with NO in remarkable detail.https://cassyni-user-files-prod.s3.amazonaws.com/AZGLL9NHPEYqC8DtnAHKhQ https://cassyni.com/slides/outline/DvWL42F4QhRm737EreRiCD https://cassyni.com/events/DvWL42F4QhRm737EreRiCD/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Aq6Vavk8DY2LX7KMqsmhzN https://cassyni.com/events/DvWL42F4QhRm737EreRiCD?videoPreview=1 On the theory of functions of omega-bounded typenohttps://cassyni.com/events/DvWL42F4QhRm737EreRiCD?videoPreview=12023-11-02T15:00:00+00:002503.44Journal of Mathematical SciencesThe general theory of holomorphic, harmonic, delta-subharmonic functions of 𝜔-bounded type in different canonical domains of the complex plane is completed. As very particular cases, the theory involves the well-known 𝐴𝛼𝑝-spaces and many classical results of R. Nevanlinna and others.https://cassyni-user-files-prod.s3.amazonaws.com/Aq6Vavk8DY2LX7KMqsmhzN https://cassyni.com/slides/outline/8z2HbBmp27tjhwPtrAiiU5 https://cassyni.com/events/8z2HbBmp27tjhwPtrAiiU5/abstract https://cassyni-user-files-prod.s3.amazonaws.com/8kVJhzuMCiaTE2B3UDPF1Q https://cassyni.com/events/8z2HbBmp27tjhwPtrAiiU5?videoPreview=1 Evolutionary history of transformation from chronic lymphocytic leukemia to Richter syndromenohttps://cassyni.com/events/8z2HbBmp27tjhwPtrAiiU5?videoPreview=12024-05-16T18:00:00+00:003080.76Center for Cancer TrainingRichter syndrome (RS) evolving from chronic lymphocytic leukemia (CLL) exemplifies an aggressive malignancy that arises from an indolent or chronic cancer. Until recently, little was known about the molecular basis of this transformation from CLL to RS. To identify the genetic events that lead to the transformation of CLL to RS, we examined paired CLL and RS samples from a cohort of 52 patients with RS by whole exome sequencing and applied computational methods to separate out the RS and CLL DNA alterations. Our work uncovered recurrent genetic alterations in RS, including gene mutations, copy number alterations, whole genome doubling and chromothripsis, which was then confirmed in an independent validation cohort. We demonstrated that RS is largely different from DLBCL based on genetics, identified signaling pathways that are dysregulated in RS cells compared to CLL cells, and traced evolution to RS at a single-cell level. Our study identified genetic subtypes within RS and showed that RS DNA alterations can be detected in plasma samples, distinct from blood CLL cells, which may be a potential method for early diagnosis or detection of RS.https://cassyni-user-files-prod.s3.amazonaws.com/8kVJhzuMCiaTE2B3UDPF1Q https://cassyni.com/events/BTGJpc1SDQfE4ssTPrdMC1/seminar/qa https://cassyni.com/slides/outline/BTGJpc1SDQfE4ssTPrdMC1 https://cassyni.com/events/BTGJpc1SDQfE4ssTPrdMC1/abstract https://cassyni-user-files-prod.s3.amazonaws.com/F6c4aHB9ZTmAnZTJd9rAeJ https://cassyni.com/events/BTGJpc1SDQfE4ssTPrdMC1?videoPreview=1 Walls, waves, and interfacial gas transfer: What is turbulence doing?nohttps://cassyni.com/events/BTGJpc1SDQfE4ssTPrdMC1?videoPreview=12024-05-21T14:00:00+00:003007.68Experiments in FluidsSeventy percent of the Earth is covered by an air-water interface dependent on the flow on either side of it. This same interface is responsible for the largest carbon sequestration process on the planet. In this talk, we will explore the studies that have led us towards the on-going “GLITR” project focused on how turbulence on either side of a gas-liquid (air-water) interface manipulates the interface itself and gas transfer across it. The story begins with the influence of external turbulence on the flow over a rigid wall, before progressing into the mutual interactions of waves and sub-surface turbulence, and ending with preliminary bulk gas transfer measurements where it is demonstrated that the sub-surface turbulence intensity can significantly influence the transfer rate of sparingly soluble gases, specifically O$_2$, even though the bulk Reynolds number is held constant. These investigations are performed experimentally in a laboratory setting using active turbulence grids to manipulate the incoming turbulent flows.https://cassyni-user-files-prod.s3.amazonaws.com/F6c4aHB9ZTmAnZTJd9rAeJ https://cassyni.com/events/VEdgbqpDRFXDESPTfQNQv9/seminar/qa https://cassyni.com/slides/outline/VEdgbqpDRFXDESPTfQNQv9 https://cassyni.com/events/VEdgbqpDRFXDESPTfQNQv9/abstract https://cassyni-user-files-prod.s3.amazonaws.com/U6XSmV26N3psVvAu3SSppe https://cassyni.com/events/VEdgbqpDRFXDESPTfQNQv9?videoPreview=1 Digital Determinants of Health: AI and the need for equity-focused innovation in digital healthnohttps://cassyni.com/events/VEdgbqpDRFXDESPTfQNQv9?videoPreview=12024-03-14T15:00:00+00:003740.04Springer Nature Sustainable Development Goals Programme*Nature Reviews Nephrology* welcomes you to this webinar, in which our two speakers — Leo Celi and Kianoush Kashani — will present on the theme of Digital Determinants of Health, with a focus on artificial intelligence (AI) and the need for equity-focused innovation. The webinar will be held on 14th of March 2024 — World Kidney Day — which this year focuses on “Advancing equitable access to care and optimal medication practice”. In their [Comment](https://www.nature.com/articles/s41581-023-00763-4.epdf?sharing_token=ihZn7Tzp1ixBfK7a3X_6x9RgN0jAjWel9jnR3ZoTv0NaWQBzIFRPdPKT7AS3IVVHez49nwrLVjZJyLsCUt5034qu70IjW6yS7U3gUuTEQjm0O_u1j1PiMZLzRs7qKAyY_28RvtE3kXcXmwKeyufyUyKP715Wx73c6p6Bfp6w6Sg%3D) “Digital determinants of health: opportunities and risks amidst health inequities”, Leo Celi and colleagues argue that given the current digital revolution, digital tools and AI applications in health care must be developed with equity at the forefront to avoid perpetuating historical biases and inequities. With their [Consensus Statement](https://www.nature.com/articles/s41581-023-00744-7) on “Digital health and acute kidney injury”, Kianoush Kashani and colleagues highlight some of the potential applications of digital health tools in nephrology, as well as the need for equitable digitization. https://cassyni-user-files-prod.s3.amazonaws.com/U6XSmV26N3psVvAu3SSppe https://cassyni.com/slides/outline/PoW36KhSbDRp72ofen8Wxm https://cassyni.com/events/PoW36KhSbDRp72ofen8Wxm/abstract https://cassyni-user-files-prod.s3.amazonaws.com/MUu5iB3UKbPYr1ByuajKzE https://cassyni.com/events/PoW36KhSbDRp72ofen8Wxm?videoPreview=1 Asymmetric C-H Functionalizationnohttps://cassyni.com/events/PoW36KhSbDRp72ofen8Wxm?videoPreview=12022-05-11T09:00:00+00:0010148.4Thieme GroupAsymmetric C–H functionalization has received increasing attention from researchers in the past decade due to its significance in the construction of molecular complexity without the need to preactivate. Distinguishing the reactivity among multiple C–H bonds in a single molecule presents very challenging issues in organic synthesis and requires rigorous reaction design.https://cassyni-user-files-prod.s3.amazonaws.com/MUu5iB3UKbPYr1ByuajKzE https://cassyni.com/slides/outline/JNNPaoafmBLjiAZS3s8iyK https://cassyni.com/events/JNNPaoafmBLjiAZS3s8iyK/abstract https://cassyni-user-files-prod.s3.amazonaws.com/PhpJRFTLJ9szNT1zCW3hSN https://cassyni.com/events/JNNPaoafmBLjiAZS3s8iyK?videoPreview=1 How Chemistry Can Enable a Circular Economynohttps://cassyni.com/events/JNNPaoafmBLjiAZS3s8iyK?videoPreview=12024-01-26T14:00:00+00:007162.6Thieme GroupNo abstracthttps://cassyni-user-files-prod.s3.amazonaws.com/PhpJRFTLJ9szNT1zCW3hSN https://cassyni.com/slides/outline/Js1zdVECCdtnhw6KeJRXEd https://cassyni.com/events/Js1zdVECCdtnhw6KeJRXEd/abstract https://cassyni-user-files-prod.s3.amazonaws.com/DQ5Az443GjgFvfJnPayiCE https://cassyni.com/events/Js1zdVECCdtnhw6KeJRXEd?videoPreview=1 12 Labours Seminar Series (Platform 3): Measuring the geometry of the human body surfacenohttps://cassyni.com/events/Js1zdVECCdtnhw6KeJRXEd?videoPreview=12024-04-02T23:00:00+00:002539.4Auckland Bioengineering InstituteUnderstanding the arrangement of bone, muscle, and fat tissue in the human body is essential for the diagnosis of diseases and the development of personalised digital twins. While imaging modalities, such as CT and MRI give accurate measurements inside the body, these modalities require bulky and expensive equipment, expert operators, and time-consuming procedures. Optical scanning of the body is a modality that is becoming cheaper and of higher spatial resolution, however it is limited to capturing the anatomy of the skin surface only. By combining optical scanning techniques with statistical models of the human anatomy, based on large datasets of internal body scans, it may be possible to perform rapid and cheap scanning of individuals to estimate their internal anatomy. This talk will present the development of a custom optical 3D scanner, that consists of an array of inward-looking high-resolution cameras surrounding a human participant, and the subsequent use of statistical shape models for the skin surface and bone anatomy estimates. https://cassyni-user-files-prod.s3.amazonaws.com/DQ5Az443GjgFvfJnPayiCE https://cassyni.com/events/Rn6TH4HYM3eaCk5u1jzTPK/seminar/qa https://cassyni.com/slides/outline/Rn6TH4HYM3eaCk5u1jzTPK https://cassyni.com/events/Rn6TH4HYM3eaCk5u1jzTPK/abstract https://cassyni-user-files-prod.s3.amazonaws.com/2RG7B9KGG2HRRj4kWhUjWE https://cassyni.com/events/Rn6TH4HYM3eaCk5u1jzTPK?videoPreview=1 Relative operator entropies and operator inequalities based on Young's inequalitynohttps://cassyni.com/events/Rn6TH4HYM3eaCk5u1jzTPK?videoPreview=12024-04-26T08:00:00+00:002938.04Advances in Operator TheoryThe relative operator entropy is defined as $S(A|B)=A^{\frac{1}{2}}(\log A^{-\frac{1}{2}}BA^{-\frac{1}{2}})A^{\frac{1}{2}}$ and the Tsallis relative operator entropy as $T_x(A|B)=\dfrac{A\ \natural_x\ B-A}{x}$ for strictly positive operators $A$ and $B$ on a Hilbert space. We extend these relative operator entropies to the $n$-th relative operator entropies $S^{[n]}(A|B)$ and $T^{[n]}_x(A|B)$ based on the Taylor expansion. Furthermore, we generalize those entropies to the $n$-th residual relative operator entropy $R^{[n]}_{x,y}(A|B)$. By using them, we introduce operator valued divergences which are extensions of the $\alpha$-divergence. We construct new inequalities among those relative operator entropies and operator valued divergences. Those inequalities contain a refinement of Young's inequality as a special case.https://cassyni-user-files-prod.s3.amazonaws.com/2RG7B9KGG2HRRj4kWhUjWE https://cassyni.com/slides/outline/UFLUWUXAYLR4ZgZTZRu67F https://cassyni.com/events/UFLUWUXAYLR4ZgZTZRu67F/abstract https://cassyni-user-files-prod.s3.amazonaws.com/24vVkfuzuToi3igx5D7per https://cassyni.com/events/UFLUWUXAYLR4ZgZTZRu67F?videoPreview=1 The gut-kidney-heart axis as a driver of cardiovascular diseasenohttps://cassyni.com/events/UFLUWUXAYLR4ZgZTZRu67F?videoPreview=12023-11-08T15:00:00+00:003124.36Imperial College Renal and Transplant CentreNo abstracthttps://cassyni-user-files-prod.s3.amazonaws.com/24vVkfuzuToi3igx5D7per https://cassyni.com/events/52s5LM7VupPK4kdcjd57Vo/seminar/qa https://cassyni.com/slides/outline/52s5LM7VupPK4kdcjd57Vo https://cassyni.com/events/52s5LM7VupPK4kdcjd57Vo/abstract https://cassyni-user-files-prod.s3.amazonaws.com/6hannfBE6gMBdE6qZJX7RQ https://cassyni.com/events/52s5LM7VupPK4kdcjd57Vo?videoPreview=1 Using storytelling to guide L2 pronunciation developmentnohttps://cassyni.com/events/52s5LM7VupPK4kdcjd57Vo?videoPreview=12024-04-19T04:10:00+00:002071.12Linguistics and Applied Language StudiesStorytelling is a central component of human communication and relationship building. For thousands of years, stories have been used to inspire and educate, to pass on knowledge to the next generation, to share personal passions and life histories and to make meaningful connections with others. Developing the ability to tell one’s story is clearly important, but in a second language (L2), achieving this aim can be quite challenging. This is especially true if problematic pronunciation gets in the way. What personal stories does the L2 learner wish to share? What kind of connections do they wish to make with other people? This is the starting point. The L2 learner’s own stories, told first in the learner’s L1, become the platform for pronunciation instruction. This talk will discuss five keys to developing clear and fluent pronunciation (based on Baker, 2021), using storytelling as the vehicle for not only this development, but for the development of learners’ overall speaking competence and willingness to communicate as well. https://cassyni-user-files-prod.s3.amazonaws.com/6hannfBE6gMBdE6qZJX7RQ https://cassyni.com/events/MqPCrHsQgWxmtttCWSkbHo/seminar/qa https://cassyni.com/slides/outline/MqPCrHsQgWxmtttCWSkbHo https://cassyni.com/events/MqPCrHsQgWxmtttCWSkbHo/abstract https://cassyni-user-files-prod.s3.amazonaws.com/TXAfRywJ7K2YNnipN4gufC https://cassyni.com/events/MqPCrHsQgWxmtttCWSkbHo?videoPreview=1 Multi-Omics Approaches for Building Software as Medical Devicesnohttps://cassyni.com/events/MqPCrHsQgWxmtttCWSkbHo?videoPreview=12024-11-20T14:00:00+00:003377.12Sage PublishingThis Special Collection calls for contributions that advance software as medical device applications for the screening, early detection, differential diagnosis, prognosis and improved clinical management of cancers. With the increasing growth in data in medicine, the development of computational methods and workflows to effectively harness this resource and turn it into actionable information is in great need. Artificial Intelligence (including deep learning, machine learning, and data analytics software) is set to play a transformative role in the future of medicine, and this Special Collection on “Software as Medical Devices for Cancer Applications” will be a timely contribution to the state-of-the-art with respect to the single most burdensome group of diseases, viz. Cancers. Image credit: [Diabetesmagazijn.nl (Unsplash)](https://unsplash.com/photos/silver-and-white-cross-pendant-necklace-z03Q6GAkqKM). Image credit: [Markus Spiske (Unsplash)](https://unsplash.com/photos/colorful-software-or-web-code-on-a-computer-monitor-Skf7HxARcoc).https://cassyni-user-files-prod.s3.amazonaws.com/TXAfRywJ7K2YNnipN4gufC https://cassyni.com/events/GtuAPTQAHwRkVoArVy3bZf/seminar/qa https://cassyni.com/slides/outline/GtuAPTQAHwRkVoArVy3bZf https://cassyni.com/events/GtuAPTQAHwRkVoArVy3bZf/abstract https://cassyni-user-files-prod.s3.amazonaws.com/C1Z331P7pMJc1c85MeMc2A https://cassyni.com/events/GtuAPTQAHwRkVoArVy3bZf?videoPreview=1 Design Optimisation of Mechanical Metamaterialsnohttps://cassyni.com/events/GtuAPTQAHwRkVoArVy3bZf?videoPreview=12024-04-30T13:00:00+00:003645.04MetaMATIn this presentation the speaker will describe the work undertaken in his group on mechanical metamaterial optimisation. This work includes the application of design optimisation methods to grade unit geometries for a range of different applications, such as frequency control, and to ensure manufacturability. He will also speak about the recent work undertaken on the design optimisation of a unit geometry to obtain complex, non-linear behaviour, accounting for large strains, contact and buckling.https://cassyni-user-files-prod.s3.amazonaws.com/C1Z331P7pMJc1c85MeMc2A https://cassyni.com/events/KN9BcsdnVECErjeR3exEHb/seminar/qa https://cassyni.com/slides/outline/KN9BcsdnVECErjeR3exEHb https://cassyni.com/events/KN9BcsdnVECErjeR3exEHb/abstract https://cassyni-user-files-prod.s3.amazonaws.com/LRVrbQPHa3GsrURQrfw9BC https://cassyni.com/events/KN9BcsdnVECErjeR3exEHb?videoPreview=1 Optimizing Chaos: Aerodynamic Design using High-Fidelity Scale Resolving Simulationsnohttps://cassyni.com/events/KN9BcsdnVECErjeR3exEHb?videoPreview=12024-09-02T13:00:00+00:003608.2Sci-Fi-TurboCurrent industry-standard aerodynamic shape optimization is performed using a combination of Reynolds Averaged Navier-Stokes (RANS) solvers and adjoint-based optimization. However, despite decades of development RANS is often deficient, particularly for separated and transitional flows. High-fidelity scale-resolving techniques, such as Large Eddy Simulation (LES) and Direct Numerical Simulation (DNS), have been demonstrably more accurate in these flow regimes. Over the past decade enabling technologies for efficient high-fidelity simulations, including high-order spatial discretizations, temporal discretizations, and many-core hardware architectures, have significantly reduced their computational cost. However, significantly less attention has been dedicated to the development of suitable optimization frameworks for LES/DNS. This talk will focus on two recently proposed optimization frameworks for LES/DNS. The first is a gradient-based approach, which uses a combination of reduced order modelling, least squares shadowing, and the adjoint. The second is a gradient-free approach using Mesh Adaptive Direct Search (MADS). It will be demonstrated that both of these frameworks are suitable for the fundamental chaotic behavior of scale resolving simulations. The utility of these frameworks will then be demonstrated for general chaotic systems, aerodynamic optimization, and aeroacoustic optimization including low-pressure turbine cascades.https://cassyni-user-files-prod.s3.amazonaws.com/LRVrbQPHa3GsrURQrfw9BC https://cassyni.com/events/XiMHmxouTg36kQtE21WxRj/seminar/qa https://cassyni.com/slides/outline/XiMHmxouTg36kQtE21WxRj https://cassyni.com/events/XiMHmxouTg36kQtE21WxRj/abstract https://cassyni-user-files-prod.s3.amazonaws.com/B5QTDLhvWDMh9fEtRBYhQJ https://cassyni.com/events/XiMHmxouTg36kQtE21WxRj?videoPreview=1 Navigating uncertainties of wastewater-based epidemiology for reliable surveillancenohttps://cassyni.com/events/XiMHmxouTg36kQtE21WxRj?videoPreview=12024-07-02T10:00:00+00:003612.36ElsevierWastewater-based epidemiology (WBE) is a cost-effective and rapid survey approach that involves sampling and detecting chemical and biological markers in wastewater. WBE has been primarily employed to reveal information about illicit drug and pharmaceutical usage, diet, lifestyle, community health, and infectious diseases. In recent years, there has been a surge in research and implementation of WBE to detect COVID-19, which is critical for early-warning and tracking community transmission. Compared to other types of epidemiological surveillance, WBE offers many advantages but also has inherent methodological limitations and associated uncertainties. This talk will address various WBE uncertainties related to biomarker shedding, in-sewer decay and transport, wastewater sampling, biomarker analysis, and the back-calculation method. Comprehensive studies, using approaches such as systematic reviews, bioreactor tests, field studies, and modeling, have been conducted to identify ways to mitigate these uncertainties. However, various protocols have been developed in different WBE programs for wastewater sampling and analysis, making cross-comparisons of data obtained by different protocols challenging. Establishing a standard or best-practice WBE protocol for sampling, analysis, and reporting would be beneficial. Additionally, we will demonstrate how machine learning can enable AI-powered WBE to become a reliable surveillance tool.https://cassyni-user-files-prod.s3.amazonaws.com/B5QTDLhvWDMh9fEtRBYhQJ https://cassyni.com/events/SmsFK8Lf56W5MKAt1Xoxhb/seminar/qa https://cassyni.com/slides/outline/SmsFK8Lf56W5MKAt1Xoxhb https://cassyni.com/events/SmsFK8Lf56W5MKAt1Xoxhb/abstract https://cassyni-user-files-prod.s3.amazonaws.com/AdnMxCythdfuLuu3mij31x https://cassyni.com/events/SmsFK8Lf56W5MKAt1Xoxhb?videoPreview=1 A theory of stochastic fluvial landscape evolutionnohttps://cassyni.com/events/SmsFK8Lf56W5MKAt1Xoxhb?videoPreview=12024-06-10T13:00:00+00:003990.96Royal Society PublishingGeometries of eroding landscapes contain important information about geologic, climatic, biotic and geomorphic processes. They are also characterized by variability, which makes disentangling their origins challenging. Observations and physical models of fluvial processes, which set the pace of erosion on most continents, emphasize complexity and variability. By contrast, the spectral content of longitudinal river profiles and similarity of geometries at scales greater than approximately 100 km highlight relatively simple emergent properties. A general challenge then, addressed in this manuscript, is development of a theory of landscape evolution that embraces such scale-dependent insights. We do so by incorporating randomness and probability into a theory of fluvial erosion. First, we explore the use of stochastic differential equations of the Langevin type, and the Fokker–Planck equation, for predicting migration of erosional fronts. Second, analytical approaches incorporating distributions of driving forces, critical thresholds and associated proxies are developed. Finally, a linear programming approach is introduced, that, at its core, treats evolution of longitudinal profiles as a Markovian stochastic problem. The theory is developed essentially from first principles and incorporates physics governing fluvial erosion. We explore predictions of this theory, including the natural growth of discontinuities and scale-dependent evolution, including local complexity and emergent simplicity.https://cassyni-user-files-prod.s3.amazonaws.com/AdnMxCythdfuLuu3mij31x https://cassyni.com/events/25T2zwzR8Cp8Brt9VKDs1w/abstract https://cassyni-user-files-prod.s3.amazonaws.com/8KfmidBV39auccwndaU4d4 https://cassyni.com/events/5XzGKjX6CQgmDZBi8ybpYm/seminar/qa https://cassyni.com/slides/outline/5XzGKjX6CQgmDZBi8ybpYm https://cassyni.com/events/5XzGKjX6CQgmDZBi8ybpYm/abstract https://cassyni-user-files-prod.s3.amazonaws.com/TsBQmtM8f3zEDcABCwxoUr https://cassyni.com/events/5XzGKjX6CQgmDZBi8ybpYm?videoPreview=1 Active Manifold and Model Order Reduction to Accelerate Multidisciplinary Analysis and Optimizationnohttps://cassyni.com/events/5XzGKjX6CQgmDZBi8ybpYm?videoPreview=12024-09-24T17:00:00+00:003773.52AIAA JournalA computational framework for efficiently solving multidisciplinary analysis and optimization (MDAO) problems in relatively high-dimensional design parameter spaces is presented. It relies on hyperreduced projection-based reduced-order models (HPROM)s; and a new concept of active manifold (AM) that mitigates the curse of dimensionality during the training of the HPROMs. The AM is discovered using a deep convolutional autoencoder for dimensionality reduction: it is proposed as a superior alternative to the concept of active subspace whose capabilities are limited by the associated affine approximation. Additionally, the presented computational framework blends the idea of global HPROMs as surrogate models of nonlinear partial differential equation (PDE)-based objective and/or constraint functions with that of a database of local, linear PROMs for approximating a linear PDE-based constraint function. The framework is demonstrated for the solution of a flexible instance of NASA's Common Research Model for transport aircraft, where the objective function pertains to aerodynamics, one of the constraint functions relates to flutter, and the design space contains 58 structural and shape parameters. The obtained results illustrate the potential of the AM concept for mitigating the aforementioned curse of dimensionality. They also demonstrate the feasibility of the computational framework proposed for realistic MDAO problems and its ability to significantly reduce solution time.https://cassyni-user-files-prod.s3.amazonaws.com/TsBQmtM8f3zEDcABCwxoUr https://cassyni.com/slides/outline/4Yh4ENE3KVacYoMi318Vjs https://cassyni.com/events/4Yh4ENE3KVacYoMi318Vjs/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Q5JWCmBydFJ7JQkYVkppdL https://cassyni.com/events/4Yh4ENE3KVacYoMi318Vjs?videoPreview=1 Soluble Graphene Nanoarchitecturesnohttps://cassyni.com/events/4Yh4ENE3KVacYoMi318Vjs?videoPreview=12024-09-03T08:00:00+00:008934.24Thieme GroupIn this Cheminar, we will delve into the latest research advancements in the organic synthesis, characterization, and application of soluble graphene nanoarchitectures. The discussion will encompass a diverse range of structures and innovative functionalizations that are pushing the boundaries of this dynamic field. The event will be chaired by Prof. Akimitsu Narita from the Okinawa Institute of Science and Technology Graduate University, Japan. Featured Speakers: • Prof. Chunyan Chi (National University of Singapore, Singapore) • Prof. Uwe Bunz (Ruprecht-Karls-University Heidelberg, Germany) • Prof. Tomoyuki Ikai (Nagoya University, Japan) https://cassyni-user-files-prod.s3.amazonaws.com/Q5JWCmBydFJ7JQkYVkppdL https://cassyni.com/slides/outline/CwiL1zDxnGzbi8iB6rTYxm https://cassyni.com/events/CwiL1zDxnGzbi8iB6rTYxm/abstract https://cassyni-user-files-prod.s3.amazonaws.com/NsNjv1tw9cuMycomQF6Gsg https://cassyni.com/events/CwiL1zDxnGzbi8iB6rTYxm?videoPreview=1 Can we make commercial aircraft faster? Mitigating transonic buffet with porous trailing edgesnohttps://cassyni.com/events/CwiL1zDxnGzbi8iB6rTYxm?videoPreview=12024-01-25T14:00:00+00:00969.36Brunton LabIn the age of globalization, commercial aviation plays a central role in maintaining our international connectivity by providing fast air transport services for passengers and freight. However, the upper limit of the aircraft flight envelope, essentially the maximum aircraft speed, is usually fixed by the occurrence of a safety-critical aerodynamic phenomenon called transonic airfoil buffet. It refers to shock wave oscillations occurring on the aircraft wings, which induce unsteady aerodynamic loads acting on the wing structure. Since these loads can cause severe structural damage endangering flight safety, the aviation industry is highly interested in suppressing transonic airfoil buffet to extend the flight envelope to higher aircraft speeds. In this contribution, we demonstrate with experimental wind tunnel measurements that the application of porous trailing edges substantially attenuates the buffet phenomenon. Since porous trailing edges have the additional benefit of reducing acoustic aircraft emissions, our findings could pave the way for faster air transport with reduced noise emissions.https://cassyni-user-files-prod.s3.amazonaws.com/NsNjv1tw9cuMycomQF6Gsg https://cassyni.com/slides/outline/FQxMFQTayZm655BjeYNBgh https://cassyni.com/events/FQxMFQTayZm655BjeYNBgh/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Rba2JMnKxTq4jKaNKDk5jL https://cassyni.com/events/FQxMFQTayZm655BjeYNBgh?videoPreview=1 Supervised Learning for Operatorsnohttps://cassyni.com/events/FQxMFQTayZm655BjeYNBgh?videoPreview=12022-05-06T14:00:00+00:004366.92AI Institute in Dynamic SystemsConsider map $F: U \to V$. Given data pairs $\{u_j,F(u_j)\}$ the goal of supervised learning is to approximate $F$. Neural networks have shown considerable success in addressing this problem in settings where $X$ is a finite dimensional Euclidean space and where $Y$ is either a finite dimensional Euclidean space (regression) or a set of finite cardinality (classification). Motivated by the need for surrogate modeling (in, for example, Bayesian inversion) and by scientific discovery (in, for example, constitutive modeling) we focus on the design and analysis of algorithms which address supervised learning for settings where $U$ and $V$ comprise spaces of functions; thus $F$ is an operator. The talk describes emerging methodology in this area, emerging theory which underpins the methodology and numerical experiments which elucidate the efficiency of different approaches. Various applications from continuum mechanics are described, including an inverse problem arising in incompressible fluid flow and constitutive modeling in viscoelasticity.https://cassyni-user-files-prod.s3.amazonaws.com/Rba2JMnKxTq4jKaNKDk5jL https://cassyni.com/slides/outline/NL4S1c2pXLSbiMsiJYsZU1 https://cassyni.com/events/NL4S1c2pXLSbiMsiJYsZU1/abstract https://cassyni-user-files-prod.s3.amazonaws.com/4k2mRJ1xRkB4FwZFiL3u42 https://cassyni.com/events/NL4S1c2pXLSbiMsiJYsZU1?videoPreview=1 Trait complementarity and functional trade-offs in plant-mycorrhizal symbiosesnohttps://cassyni.com/events/NL4S1c2pXLSbiMsiJYsZU1?videoPreview=12024-06-07T16:00:00+00:00927.12New Phytologist Foundation The criteria by which plants select symbiotic partners are largely unknown, but functional complementarity of partner traits could be important to symbioses such as arbuscular mycorrhizas. Specifically, coarse-rooted plants are more likely to be limited by nutrient diffusion compared with fine-rooted plants, and therefore more reliant on fungi that can compensate with traits that maximize soil exploration. However there remains no evidence directly linking plant root traits and fungal functional traits. We tested the hypothesis that coarse-rooted plants associate with fungal partners that provide nutrient benefit by increased hyphal exploration. We collected roots from 30 plant species ranging from fine to coarse roots and used Next Generation Sequencing to identify the arbuscular mycorrhizal fungal community associated with each plant species. We found that plant root diameter was correlated with arbuscular mycorrhizal fungal community composition and diversity. We quantified exploration using root fragments from the same 30 species inoculated onto a common host plant grown in multi-compartment pots. Root fragments from coarse-rooted plants were associated with an increase in hyphal exploration away from the roots. Our results provide the first direct evidence of functional complementarity between plants and their arbuscular mycorrhizal fungal partners with important implications for fungal diversity and coexistence.https://cassyni-user-files-prod.s3.amazonaws.com/4k2mRJ1xRkB4FwZFiL3u42 https://cassyni.com/events/Npi34HgLxnzei8QbtzAMjK/seminar/qa https://cassyni.com/slides/outline/Npi34HgLxnzei8QbtzAMjK https://cassyni.com/events/Npi34HgLxnzei8QbtzAMjK/abstract https://cassyni-user-files-prod.s3.amazonaws.com/QSnhzGvcxLiBZ9issuiDY2 https://cassyni.com/events/Npi34HgLxnzei8QbtzAMjK?videoPreview=1 Emerging Trends in Glycoscience, Part #1nohttps://cassyni.com/events/Npi34HgLxnzei8QbtzAMjK?videoPreview=12024-07-22T07:00:00+00:006524.16Thieme GroupCarbohydrates are essential biomolecules with significant roles in chemistry, biology, and medicine. The "Emerging Trends in Glycoscience" issue highlights advancements in synthetic carbohydrate chemistry and their applications. It features 22 contributions, including reviews and original research, covering topics like molecular scaffolding, catalysis, and medicinal chemistry, providing insights into carbohydrate-based pharmacological developments. Our speakers: 1) Prof. Vito Ferro (University of Queensland): Exploiting the fluorine-directing effect to access rare L-hexoses. 2) Prof. Daisuke Takahashi (Keio University): Synthesis and immunological evaluation of oligosaccharide-protein conjugates for the development of a vaccine against avian pathogenic Escherichia coli O1. https://cassyni-user-files-prod.s3.amazonaws.com/QSnhzGvcxLiBZ9issuiDY2 https://cassyni.com/events/HPaPYmZa8kuaKGANJ5AZjs/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Edv6qa5u8XWo3suWXJWS7g https://cassyni.com/slides/outline/VjnVhrjh7CkSCwQBGRjHt1 https://cassyni.com/events/VjnVhrjh7CkSCwQBGRjHt1/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Bf8VbRE9ny66eFEYMjAGfY https://cassyni.com/events/VjnVhrjh7CkSCwQBGRjHt1?videoPreview=1 From mechanoregulation to inflammation of the osteoarthritic jointnohttps://cassyni.com/events/VjnVhrjh7CkSCwQBGRjHt1?videoPreview=12024-07-23T04:00:00+00:003326.84The Auckland Bioengineering InstituteDuring this seminar I will review some of my early contributions to the mechanobiology field in fracture healing and tissue engineering, in particular on how computational models of scaffolds for tissue engineering can be used to quantify the local mechanical stimuli experienced by cells. This will lead me to discuss the importance of inflammation and biomechanics in osteoarthritis and present the latest development of a mathematical model of inflammation for osteoarthritis.https://cassyni-user-files-prod.s3.amazonaws.com/Bf8VbRE9ny66eFEYMjAGfY https://cassyni.com/events/81FufnGbo4P2QC7ttLLdBb/abstract https://cassyni-user-files-prod.s3.amazonaws.com/VU3LtuKdQijZ6me9SdKKki https://cassyni.com/slides/outline/DSPZBJPNd6URXbhgtxaX8y https://cassyni.com/events/DSPZBJPNd6URXbhgtxaX8y/abstract https://cassyni-user-files-prod.s3.amazonaws.com/3cLm3492ibApNaUqCGNYar https://cassyni.com/events/DSPZBJPNd6URXbhgtxaX8y?videoPreview=1 The Size of the Centre of a Vector Latticenohttps://cassyni.com/events/DSPZBJPNd6URXbhgtxaX8y?videoPreview=12021-03-11T14:00:00+00:002434.96Positivity Journal, SpringerNatureI will survey the extreme sizes that the centre of a vector lattice can take and suggest some possible directions for related future research.https://cassyni-user-files-prod.s3.amazonaws.com/3cLm3492ibApNaUqCGNYar https://cassyni.com/slides/outline/9yrKrWrhYtbnVuQ8FJCZc9 https://cassyni.com/events/9yrKrWrhYtbnVuQ8FJCZc9/abstract https://cassyni-user-files-prod.s3.amazonaws.com/2V5tgvojTaXvLrRv3Y6Wna https://cassyni.com/events/9yrKrWrhYtbnVuQ8FJCZc9?videoPreview=1 Dogs with a vocabulary of object labels retain them for at least 2 yearsnohttps://cassyni.com/events/9yrKrWrhYtbnVuQ8FJCZc9?videoPreview=12024-08-16T12:00:00+00:00786.52Royal Society PublishingLong-term memory of words has a crucial role in the developing abilities of young ‎children to acquire language. In dogs, the ability to learn object labels is present in only a ‎small group of uniquely Gifted Word Learner (GWL) dogs. As they are very rare, little is ‎known about the mechanisms through which they acquire such large vocabularies. In the ‎current study, we tested the ability of five GWL dogs to retrieve 12 labelled objects two ‎years after the object-label mapping acquisition. The dogs proved to remember the labels ‎of between 3-9 objects. The results shed light on the process by which GWL dogs acquire ‎an exceptionally large vocabulary of object names. As memory plays a crucial role in ‎language development, these dogs supply a unique opportunity to study label retention ‎in a non-linguistic species.‎ This seminar discusses the article: Dror S, Miklósi Á, Fugazza C. 2024 Dogs with a vocabulary of object labels retain them for at least 2 years. Biol. Lett. 20:20240208. https://doi.org/10.1098/rsbl.2024.0208https://cassyni-user-files-prod.s3.amazonaws.com/2V5tgvojTaXvLrRv3Y6Wna https://cassyni.com/slides/outline/WETisAu6x2EG2QPh4XrG4D https://cassyni.com/events/WETisAu6x2EG2QPh4XrG4D/abstract https://cassyni-user-files-prod.s3.amazonaws.com/M3FAa5jpSUumhQuuPAESfg https://cassyni.com/events/WETisAu6x2EG2QPh4XrG4D?videoPreview=1 AI in the Academy: A Collaborative Debatenohttps://cassyni.com/events/WETisAu6x2EG2QPh4XrG4D?videoPreview=12024-08-27T12:00:00+00:003811.52Cassyni SeminarsThe emergence of artificial intelligence (AI) is swiftly changing the landscape of academia, the tools at our disposal as academics, how we teach, research, and produce knowledge. AI could be viewed as a game-changer; automating and outsourcing mundane tasks and processes. Or a threat to the ‘core business’ of intellectual life, or raise questions about how knowledge is produced and used, especially in Aotearoa New Zealand. This collaborative debate draws together the perspectives of academics from across Te Herenga Waka Victoria University of Wellinton, inviting a critical conversation that explores the promises and perils of AI in academia. AI in the Academy is a collaborative debate. In this format, speakers are encouraged to find common ground before presenting their differing viewpoints. The goal is not necessarily to win over the other side, but to reach a deeper understanding of the issue, challenges, and opportunities of AI. This type of debate emphasises listening, mutual understanding, open-mindedness, and respect for different perspectives. https://cassyni-user-files-prod.s3.amazonaws.com/M3FAa5jpSUumhQuuPAESfg https://cassyni.com/events/RHygQLRrZShEdJgM449GL5/seminar/qa https://cassyni.com/slides/outline/RHygQLRrZShEdJgM449GL5 https://cassyni.com/events/RHygQLRrZShEdJgM449GL5/abstract https://cassyni-user-files-prod.s3.amazonaws.com/NuvM1QJLzBjgFVNGe3vC6i https://cassyni.com/events/RHygQLRrZShEdJgM449GL5?videoPreview=1 The Future of Timekeeping: Embracing Nonlinearity for Improved Precisionnohttps://cassyni.com/events/RHygQLRrZShEdJgM449GL5?videoPreview=12024-10-01T13:00:00+00:002420.68Nonlinear Dynamics, an International Journal of Nonlinear Dynamics and Chaos in Engineering SystemsHigh precision timekeeping is essential for activities such as telecommunications and navigation. Modern clocks are self-sustained oscillators based on a lightly damped resonator with feedback that generates a limit cycle of a desired frequency. Resonator elements have historically evolved from Huygens’ isochronous pendulum to quartz crystals to atomic level transitions to micro- mechanical structures. Increasing the precision of a clock depends on mitigating the effects of noise and typically involves operating at resonator amplitudes near the onset of nonlinearity. In this talk I will provide a brief background about clock dynamics and describe how understanding the interplay of nonlinearity and noise is important for advancing clock precision. The talk will emphasize predictive modeling and experimental results from micro-electro-mechanical oscillators. **Key Learning Objectives** - Clocks are modeled by limit cycles with a counter - Clock precision is described by frequency stability which depends on noise properties of the resonator and supporting electronics - Micro-scale resonators consist of tiny vibrating structures that interface with electronics and are ubiquitous in modern electronics - These devices are essential components in cell phones, computers, vehicle stability systems, etc. - Clock precision can be improved by going beyond the linear range, which requires an understanding of the interplay of nonlinearity and noise **Who Should Attend** - Mechanical and electrical engineers - Applied physicists - Researchers/scientists in electro-mechanical systems and nonlinear dynamics - MEMS Research/Project managershttps://cassyni-user-files-prod.s3.amazonaws.com/NuvM1QJLzBjgFVNGe3vC6i https://cassyni.com/slides/outline/62h7bgCPSb6Mridr8kYxds https://cassyni.com/events/62h7bgCPSb6Mridr8kYxds/abstract https://cassyni-user-files-prod.s3.amazonaws.com/VpzVGqKUpthdBpLoG9TsMY https://cassyni.com/events/62h7bgCPSb6Mridr8kYxds?videoPreview=1 Unusual, large, and alternatively coded phages are prevalent in the human microbiomenohttps://cassyni.com/events/62h7bgCPSb6Mridr8kYxds?videoPreview=12021-10-14T10:00:00+00:002116.04Microbiome Virtual International Forum No abstracthttps://cassyni-user-files-prod.s3.amazonaws.com/VpzVGqKUpthdBpLoG9TsMY https://cassyni.com/slides/outline/MLpU9VmYT9Boz7v4wWVfMo https://cassyni.com/events/MLpU9VmYT9Boz7v4wWVfMo/abstract https://cassyni-user-files-prod.s3.amazonaws.com/PVKVUJE8EkUE7d1DpW6bgA https://cassyni.com/events/MLpU9VmYT9Boz7v4wWVfMo?videoPreview=1 A catalogue of small proteins from the global microbiomenohttps://cassyni.com/events/MLpU9VmYT9Boz7v4wWVfMo?videoPreview=12024-04-17T15:00:00+00:00566.04Microbiome Virtual International Forum Small Open Reading Frames (smORFs, operationally defined as those with fewer than 100 codons) are often neglected due to the limitation of computational and experimental methods. Recently, systematic studies have shown that smORFs are widely distributed ecologically and perform diverse functions. However, little is known about the distribution and role of smORFs in the global microbiome. Therefore, we constructed the global microbial smORFs catalogue (GMSC) from 63,410 publicly-available metagenomes across 72 distinct habitats and 87,920 high-quality isolated microbial genomes. GMSC (available at <https://gmsc.big-data-biology.org/>) contains 964,970,496 non-redundant smORFs, the majority of which are novel. We found that archaea harbor more small proteins than bacteria (as a fraction of their genomes). To enable the use of this resource, we provide a tool called GMSC-mapper that can identify and annotate reliable smORFs from microbial genomes and metagenomes. The resource shows an immense and underexplored diversity of smORFs and can be used to research the presence, distribution, and role of smORFs at the global scale.https://cassyni-user-files-prod.s3.amazonaws.com/PVKVUJE8EkUE7d1DpW6bgA https://cassyni.com/events/Wj7KurYdPUnK2Avaey94KX/seminar/qa https://cassyni.com/slides/outline/Wj7KurYdPUnK2Avaey94KX https://cassyni.com/events/Wj7KurYdPUnK2Avaey94KX/abstract https://cassyni-user-files-prod.s3.amazonaws.com/5E5xDKvSX2Vz5Gw7xxhXg2 https://cassyni.com/events/Wj7KurYdPUnK2Avaey94KX?videoPreview=1 Hamilton compression in Vertex-transitive Graphsnohttps://cassyni.com/events/Wj7KurYdPUnK2Avaey94KX?videoPreview=12024-09-25T15:00:00+00:003003.96The Journal of Algebraic CombinatoricsGiven a graph $X$ with a Hamilton cycle $C$, the compression factor $\kappa(X,C)$ of $C$ is the order of the largest cyclic subgroup of $C\cap X$, and the Hamilton compression $\kappa(X)$ of $X$ is the maximum of $\kappa(X,C)$ where $C$ runs over all Hamilton cycles in $X$. Motivated by Gregor, Merino and Mütze generalization of the well-known open problem regarding the existence of vertex-transitive graphs without Hamilton paths/cycles we have recently started to investigate existence of Hamilton cycles, admitting large rotational symmetry, in certain families of vertex-transitive graphs. In this talk I will present the results obtained thus far with a special emphasis given to the importance of the so-called Polycirculant conjecture when investigating Hamilton compression in vertex-transitive graphs. The work discussed in this talk is a joint work with Dragan Marušič and Andriaherimanana Sarobidy Razafimahatratra. https://cassyni-user-files-prod.s3.amazonaws.com/5E5xDKvSX2Vz5Gw7xxhXg2 https://cassyni.com/slides/outline/8Vw8q6S1dsrrDf7QgSTbMo https://cassyni.com/events/8Vw8q6S1dsrrDf7QgSTbMo/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Kc3pjeUCU8ERHNGHUQ5v4E https://cassyni.com/events/8Vw8q6S1dsrrDf7QgSTbMo?videoPreview=1 Association between delivery mode and the healthy newborn meconium microbiota: a systematic reviewnohttps://cassyni.com/events/8Vw8q6S1dsrrDf7QgSTbMo?videoPreview=12021-12-08T14:00:00+00:0064.44Microbiome Virtual International Forum Meconium is the newborn’s earliest fecal discharge, representing the intestinal content during in utero life, and was formerly thought to be sterile. Recent hypotheses of how meconium microbiota communities are formed include initial colonization during gestation and further influence by delivery mode and other perinatal factors including maternal health. We examined reports of differentially abundant meconium microbiota and alpha diversity by delivery mode (vaginal versus C-section) for newborns of healthy women. Ten articles met criteria for inclusion, representing 601 vaginal deliveries and 281 C-sections. Reported signatures were standardized using the NCBI taxonomy, and reports of differential alpha diversity were recorded. The only concordance in differential abundance signatures was in the genus Stenotrophomonas, reported in two of 10 studies as overabundant in the meconium of C-section delivery newborns when compared to newborns of vaginal delivery, and Enterococcus, reported in two of 10 studies as less abundant. In conclusion, little consistency is seen in published results on over or under abundance of meconium microbiota by delivery mode. Mode of delivery may play a role in the meconium microbiota; however, low replicability across studies limits conclusions that can be drawn about the contribution of mode of delivery to the infant gut microbiome. Future microbiome studies of low microbial biomass meconium should take extra measures to avoid sample contamination, employ negative controls to assess the effectiveness of these measures, set clearly defined inclusion and exclusion criteria for consistency with previous studies (particularly for antibiotics usage and gestational age), and have larger sample sizes.https://cassyni-user-files-prod.s3.amazonaws.com/Kc3pjeUCU8ERHNGHUQ5v4E https://cassyni.com/slides/outline/16D58qj941ZLTcvW8Gqxuj https://cassyni.com/events/16D58qj941ZLTcvW8Gqxuj/abstract https://cassyni-user-files-prod.s3.amazonaws.com/FHWu9p8neB2ZoFVeUPqWj8 https://cassyni.com/events/16D58qj941ZLTcvW8Gqxuj?videoPreview=1 Autism-related dietary preferences mediate autism-gut microbiome associationsnohttps://cassyni.com/events/16D58qj941ZLTcvW8Gqxuj?videoPreview=12022-02-08T11:00:00+00:00630.0Microbiome Virtual International Forum There is increasing interest in the potential contribution of the gut microbiome to autism spectrum disorder (ASD). However, previous studies have been underpowered and have not been designed to address potential confounding factors in a comprehensive way. We performed a large autism stool metagenomics study (n = 247) based on participants from the Australian Autism Biobank and the Queensland Twin Adolescent Brain project. We found negligible direct associations between ASD diagnosis and the gut microbiome. Instead, our data support a model whereby ASD-related restricted interests are associated with less-diverse diet, and in turn reduced microbial taxonomic diversity and looser stool consistency. In contrast to ASD diagnosis, our dataset was well powered to detect microbiome associations with traits such as age, dietary intake, and stool consistency. Overall, microbiome differences in ASD may reflect dietary preferences that relate to diagnostic features, and we caution against claims that the microbiome has a driving role in ASD.https://cassyni-user-files-prod.s3.amazonaws.com/FHWu9p8neB2ZoFVeUPqWj8 https://cassyni.com/slides/outline/3ZT6NFxmFJKppZQ4fxkbdf https://cassyni.com/events/3ZT6NFxmFJKppZQ4fxkbdf/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Xi3cput6qHW8vmDzJ6RUgE https://cassyni.com/events/3ZT6NFxmFJKppZQ4fxkbdf?videoPreview=1 C. difficile is overdiagnosed in adults and a commensal in infantsnohttps://cassyni.com/events/3ZT6NFxmFJKppZQ4fxkbdf?videoPreview=12022-05-10T12:00:00+00:00618.0Microbiome Virtual International Forum Clostridioides difficile is an urgent threat in hospital-acquired infections world-wide, yet the microbial composition associated with C. difficile, in particular in C. difficile infection (CDI) cases, remains poorly characterised. Here, we analysed 534 metagenomes from 10 publicly available CDI study populations. While we detected C. difficile in only 30% of CDI samples, multiple other toxigenic species capable of inducing CDI-like symptomatology were prevalent, raising concerns about CDI overdiagnosis. We further tracked C. difficile in 42,814 metagenomic samples from 253 public studies. We found that C. difficile prevalence, abundance and association with other bacterial species is age-dependent. In healthy adults, C. difficile is a rare taxon associated with an overall species richness reduction, while in healthy infants C. difficile is a common member of the gut microbiome and its presence is associated with a significant increase in species richness. More specifically, we identified a group of species co-occurring with C. difficile exclusively in healthy infants, enriched in obligate anaerobes and in species typically found in the gut microbiome of healthy adults. Overall, gut microbiome composition in presence of C. difficile in healthy infants is associated with multiple parameters linked to a healthy gut microbiome maturation towards an adult-like state. Our results suggest that C. difficile is a commensal in infants, and that its asymptomatic carriage is dependent on the surrounding microbial context.https://cassyni-user-files-prod.s3.amazonaws.com/Xi3cput6qHW8vmDzJ6RUgE https://cassyni.com/slides/outline/AUXZ1q27Pi5cKNPe3QKXnM https://cassyni.com/events/AUXZ1q27Pi5cKNPe3QKXnM/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Mhv8e52iwmHjyn8xk3UFd8 https://cassyni.com/events/AUXZ1q27Pi5cKNPe3QKXnM?videoPreview=1 Recurrent urinary tract infection and estrogen shape the taxonomic ecology and function of the postmenopausal urogenital microbiomenohttps://cassyni.com/events/AUXZ1q27Pi5cKNPe3QKXnM?videoPreview=12022-11-08T14:00:00+00:00868.04Microbiome Virtual International Forum Postmenopausal women are severely affected by recurrent urinary tract infection (rUTI). The urogenital microbiome is a key component of the urinary environment. However, changes in the urogenital microbiome underlying rUTI susceptibility are unknown. Here, we perform shotgun metagenomics and advanced culture on urine from a controlled cohort of postmenopausal women to identify urogenital microbiome compositional and function changes linked to rUTI susceptibility. We identify candidate taxonomic biomarkers of rUTI susceptibility in postmenopausal women and an enrichment of lactobacilli in postmenopausal women taking estrogen hormone therapy. We find robust correlations between Bifidobacterium and Lactobacillus and urinary estrogens in women without urinary tract infection (UTI) history. Functional analyses reveal distinct metabolic and antimicrobial resistance gene (ARG) signatures associated with rUTI. Importantly, we find that ARGs are enriched in the urogenital microbiomes of women with rUTI history independent of current UTI status. Our data suggest that rUTI and estrogen shape the urogenital microbiome in postmenopausal women. Link to OA paper: https://www.cell.com/cell-reports-medicine/fulltext/S2666-3791(22)00302-0https://cassyni-user-files-prod.s3.amazonaws.com/Mhv8e52iwmHjyn8xk3UFd8 https://cassyni.com/slides/outline/HtHEpiEsNwKAxRcWHr7hpy https://cassyni.com/events/HtHEpiEsNwKAxRcWHr7hpy/abstract https://cassyni-user-files-prod.s3.amazonaws.com/FefdZmgo8wKvHMMdYDdcNr https://cassyni.com/events/HtHEpiEsNwKAxRcWHr7hpy?videoPreview=1 Advances in cpn60 barcoding for microbial species identificationnohttps://cassyni.com/events/HtHEpiEsNwKAxRcWHr7hpy?videoPreview=12023-09-19T16:00:00+00:00540.84Microbiome Virtual International Forum The “universal target” region of the gene encoding the 60 kDa chaperonin protein (cpn60, also known as groEL or hsp60) is a proven sequence barcode for bacteria and a useful target for marker gene amplicon-based studies of complex microbial communities. Application of cpn60 barcode sequencing is facilitated by 'universal' amplification primers and cpnDB, a manually curated reference database of cpn60 sequences. Recent developments to the cpn60 platform include demonstration that 150 bp from the 5' end of the barcode is sufficient for species level resolution of bacteria. These short sequences can be identified using established sequence classifiers (QIIME2 feature classifier and RDP classifier), making it simple to integrate cpn60 amplicon sequence identification into existing microbiome analysis pipelines, as recently demonstrated for human skin, vaginal, salivary and stool microbiomes. The purpose of this presentation is to provide a brief overview of cpn60 barcoding resources and applications, and to highlight recent research advances. Link to OA paper: https://www.nature.com/articles/s43705-023-00283-zhttps://cassyni-user-files-prod.s3.amazonaws.com/FefdZmgo8wKvHMMdYDdcNr https://cassyni.com/slides/outline/LMXG48UVaE5fKN64qY2LYu https://cassyni.com/events/LMXG48UVaE5fKN64qY2LYu/abstract https://cassyni-user-files-prod.s3.amazonaws.com/C4xzypFExNKFqQjHmAxXD8 https://cassyni.com/events/LMXG48UVaE5fKN64qY2LYu?videoPreview=1 Analyzing microbial evolution through gene and genome phylogeniesnohttps://cassyni.com/events/LMXG48UVaE5fKN64qY2LYu?videoPreview=12023-12-19T13:00:00+00:00738.0Microbiome Virtual International Forum Microbiome scientists critically need modern tools to explore and analyze microbial evolution. Often this involves studying the evolution of microbial genomes as a whole. However, different genes in a single genome can be subject to different evolutionary pressures, which can result in distinct gene-level evolutionary histories. To address this challenge, we propose to treat estimated gene-level phylogenies as data objects, and present an interactive method for the analysis of a collection of gene phylogenies. We use a local linear approximation of phylogenetic tree space to visualize estimated gene trees as points in low-dimensional Euclidean space, and address important practical limitations of existing related approaches, allowing an intuitive visualization of complex data objects. We demonstrate the utility of our proposed approach through microbial data analyses, including by identifying outlying gene histories in strains of Prevotella, and by contrasting Streptococcus phylogenies estimated using different gene sets. Our method is available as an open-source R package, and assists with estimating, visualizing, and interacting with a collection of bacterial gene phylogenies. Link to OA paper: https://doi.org/10.1093/biostatistics/kxad025https://cassyni-user-files-prod.s3.amazonaws.com/C4xzypFExNKFqQjHmAxXD8 https://cassyni.com/slides/outline/UkYXqkUR31VeUhSXuPMPmo https://cassyni.com/events/UkYXqkUR31VeUhSXuPMPmo/abstract https://cassyni-user-files-prod.s3.amazonaws.com/KyeWygGPQfMSoYNHsmE8zr https://cassyni.com/events/UkYXqkUR31VeUhSXuPMPmo?videoPreview=1 Evolution of the breastfed infant gut microbiome across the first year of life in the BLOSOM cohortnohttps://cassyni.com/events/UkYXqkUR31VeUhSXuPMPmo?videoPreview=12023-04-19T13:00:00+00:00640.04Microbiome Virtual International Forum Background. Assembly of the human gut microbiome during early life is a complex and dynamic process. Aberrations to the early gut microbiome have been repeatedly associated with later-life disease. While previous studies have explored the temporal development of the infant gut microbiome, none have done so in an exclusively breastfed population, nor in an Australian context. Here, we characterized the temporal development of the breastfed infant gut microbiome over the first 12 months of life in the BLOSOM birth cohort. Methods. Infant stool samples were collected at 2-5 days, and 1, 2, 3, 4, 5, 6, 9, and 12 months of age (n=684 samples from 85 infants). The gut microbiome was analysed using PacBio full-length 16S rRNA gene sequencing. Results. Exclusive breastfeeding was a strong determinant of the infant gut microbiome, with introduction of solid food driving a rapid and dramatic expansion in the gut community. Richness and Shannon diversity remained stable over the first 5 months of life, followed by a significant increase in diversity from 6 to 12 months (P&lt;0.0001). Bifidobacterium was the dominant genera in this cohort, with Bifidobacterium longum supsp. infantis representing the most abundant species (27% relative abundance across all samples). Bifidobacterium relative abundance increased across the first 4 months of life from a mean relative abundance of 23% at 2-5 days to 46% at 4 months. Bifidobacterium levels then began to steadily decline from 5 to 12 months (12 month mean relative abundance = 33%). The persistence of this health-promoting genera a 12 months of age is likely a reflection of the high breastfeeding retention rates in the BLOSOM cohort (&gt;80% still breastfeeding at 12 months of age). C-section delivery was a major determinant of the infant gut microbiome, with significant impacts on Bifidobacteria and Bacteroides. Similar impacts were seen in vaginally delivered infants whose mothers were exposed to intrapartum antibiotic prophylaxis, suggesting that antibiotic exposure related to delivery mode, rather than delivery mode per se, is responsible for the effect. Conclusion. In the first study of gut microbiome assembly in exclusively breastfed Australian infants, we demonstrate a high abundance of Bifidobacterium that persists to 12 months of age. Our results also demonstrate the dramatic impact of introduction of solid foods, and exposure to intra-partum antibiotics. These data illustrate “optimal” infant gut microbiome development associated with vaginal delivery and breastfeeding.https://cassyni-user-files-prod.s3.amazonaws.com/KyeWygGPQfMSoYNHsmE8zr https://cassyni.com/slides/outline/XDnZ5Ai3EJG8qdv6T5G2Vj https://cassyni.com/events/XDnZ5Ai3EJG8qdv6T5G2Vj/abstract https://cassyni-user-files-prod.s3.amazonaws.com/X9ZTnPXo1uhvna6xjvGM8J https://cassyni.com/events/XDnZ5Ai3EJG8qdv6T5G2Vj?videoPreview=1 The effect of buoyancy on pollution trapping in the wake of a stepnohttps://cassyni.com/events/XDnZ5Ai3EJG8qdv6T5G2Vj?videoPreview=12024-05-08T10:00:00+00:003127.04Department of Aeronautics and AstronauticsWhen wind blows over a row of houses, what happens to pollution emitted by vehicles driving in the building wakes? This talk will describe reduced-scale laboratory experiments that investigate a simplified version of this common urban fluid mechanics problem. The experiments focus on the effect of buoyancy on pollution dispersion in the wake of a step. The results are compared to a simple model that describes the competing effects of inertia and buoyancy forces in the wake and how these affect pollution trapping behind the step.https://cassyni-user-files-prod.s3.amazonaws.com/X9ZTnPXo1uhvna6xjvGM8J https://cassyni.com/events/TmFKkPBNA6PVowcXoQt4xu/abstract https://cassyni-user-files-prod.s3.amazonaws.com/XH1LA7z6htwyYYUNYFUMCS https://cassyni.com/slides/outline/VEuuk8y5SrnUgumdZF9W1B https://cassyni.com/events/VEuuk8y5SrnUgumdZF9W1B/abstract https://cassyni-user-files-prod.s3.amazonaws.com/JY8Z2wPuBVzn3HetoPkVok https://cassyni.com/events/VEuuk8y5SrnUgumdZF9W1B?videoPreview=1 Experimental Study on Dynamic Characteristics of a Geared Turbo Fan Engine Rotor Systemnohttps://cassyni.com/events/VEuuk8y5SrnUgumdZF9W1B?videoPreview=12025-06-24T02:00:00+00:00567.36NODYSBecause of some significant merits like high efficiency and low pollution, the geared turbo fan (GTF) engine has attracted wide attention in recent years. However, extra gearbox between the fan rotor and low-pressure (LP) turbine rotor introduces additional coupling effects, resulting in more complicated rotor dynamic characteristics. Thus, it is very important and meaningful to study these dynamic characteristics for the structural design and vibration control of the GTF engine rotor system. For this objective, some experimental cases on a lab GTF engine rotor system are studied in this paper. Firstly, the configuration of the lab GTF engine rotor system is introduced, and then experimental equipment and plan are shown. After that, dynamic testing for the critical speed, mode shape and dynamic response of the lab GTF engine rotor system is implemented. Experimental results demonstrate that the first three critical speeds of the lab GTF engine rotor system are 2356 r/min, 4606 r/min and 6318 r/min respectively corresponding to different mode shapes. With the rise of the rotating speed from 0 to 5000 r/min, both response amplitudes of the fan and turbine disks increase, and get maximum results at the second-order critical speed (4606 r/min).https://cassyni-user-files-prod.s3.amazonaws.com/JY8Z2wPuBVzn3HetoPkVok https://cassyni.com/slides/outline/RnNgRMSQNeuqfDU4uamYUM https://cassyni.com/events/RnNgRMSQNeuqfDU4uamYUM/abstract https://cassyni-user-files-prod.s3.amazonaws.com/KmkZeeWiH9P2Dktg5EhpAi https://cassyni.com/events/RnNgRMSQNeuqfDU4uamYUM?videoPreview=1 Forced Vibrations of Multi-Cracked Shear Deformable Beams by Means of Extended Modal Analysisnohttps://cassyni.com/events/RnNgRMSQNeuqfDU4uamYUM?videoPreview=12025-06-24T10:00:00+00:00742.04NODYSShear deformable beams modelled in accordance with the first order Timoshenko theory in presence of multiple cracks are the object of this study. The contribution provided by this work consists, first, in the derivation of the “extended” mode shapes explicitly formulated, by means of a distributional approach, to include the effect of multiple cracks. Then, it is proved that the orthogonality property of the proposed mode shapes embedding the effect of multiple cracks is preserved. On this ground, forced vibrations of the multi-cracked beam are analysed by making use of extended modal superposition by exploiting explicit expressions of the impulse response functions.https://cassyni-user-files-prod.s3.amazonaws.com/KmkZeeWiH9P2Dktg5EhpAi https://cassyni.com/slides/outline/UFchemg2ZwgL29wdTGgBCH https://cassyni.com/events/UFchemg2ZwgL29wdTGgBCH/abstract https://cassyni-user-files-prod.s3.amazonaws.com/ETowWvphxqN4oTAMx3jFzn https://cassyni.com/events/UFchemg2ZwgL29wdTGgBCH?videoPreview=1 Morphing Aeroelasticity of UAV Wing with Sliding Telescope Dynamics and Unsteady Aerodynamicsnohttps://cassyni.com/events/UFchemg2ZwgL29wdTGgBCH?videoPreview=12025-06-24T11:00:00+00:00955.4NODYSTelescopic morphing wing (TMW) technology offers several benefits, including improved aerodynamic performance, increased manoeuvrability, better fuel efficiency, and wider flight capabilities. However, modelling and analyzing these morphing mechanisms is highly challenging. A mathematical model that closely approximates reality is developed to investigate the effects of morphing on the aeroelastic behaviour of TMW structures. Inertial and elastic coupling between the beams is captured in this proposed dynamic modelling. The aerodynamic forces and moments acting on the wing are modelled using Wagner's unsteady aerodynamic formulations to obtain pure time-domain equations of motion. The non-stationary nature of the system parameters during morphing introduces nonlinear characteristics. Numerical simulations demonstrate complex dynamics, including energy transfer between beams and transient chaotic response during the morphing process.https://cassyni-user-files-prod.s3.amazonaws.com/ETowWvphxqN4oTAMx3jFzn https://cassyni.com/slides/outline/539JUeGMwReaXE1ndTrCaq https://cassyni.com/events/539JUeGMwReaXE1ndTrCaq/abstract https://cassyni-user-files-prod.s3.amazonaws.com/GZZkxqKgq2iUuefb7akVp2 https://cassyni.com/events/539JUeGMwReaXE1ndTrCaq?videoPreview=1 Bio-Inspired Small UAV: Nonlinear Modelling and Simulationnohttps://cassyni.com/events/539JUeGMwReaXE1ndTrCaq?videoPreview=12025-06-24T11:00:00+00:00577.92NODYSThis research considers the development of a nonlinear model of a raven which lacks a vertical tail. The aerodynamic coefficients are obtained using the AVL (developed by MIT). The aircraft’s wings are designed to morph, thereby introducing a variable dihedral angle on the wings and creating an extra degree of freedom to control the UAV, but creating a complex and challenging modelling and control problem. Iterations and runs were conducted on AVL to acquire a comprehensive set of aerodynamic coefficients with varying dihedral angles. This set of coefficients is then implemented in SIMULINK to create the nonlinear model of the UAV. The nonlinear SIMULINK UAV model is then used to generate a family of linear models at various dihedral angles, which are subsequently used to develop an LPV model. The nonlinear and LPV models developed in this work lay a solid foundation for subsequent advanced controller designs, including the LPV-based sliding mode control with control allocation. Despite the lack of a vertical tail, this controller is robust against any uncertainties and disturbances in the input channels, including actuator faults and failures.https://cassyni-user-files-prod.s3.amazonaws.com/GZZkxqKgq2iUuefb7akVp2 https://cassyni.com/events/CwYbLD8eN7SEqGXmPSpuB3/abstract https://cassyni-user-files-prod.s3.amazonaws.com/XEK33DR54PNAS9a7VSmPCS https://cassyni.com/slides/outline/FQncZdNGZQCjCD1Kw8jXty https://cassyni.com/events/FQncZdNGZQCjCD1Kw8jXty/abstract https://cassyni-user-files-prod.s3.amazonaws.com/S3WC4384T5ZBYzjf4QFam4 https://cassyni.com/events/FQncZdNGZQCjCD1Kw8jXty?videoPreview=1 Optimisation of Gyrokinetic Microstability Using Adjoint Methodsnohttps://cassyni.com/events/FQncZdNGZQCjCD1Kw8jXty?videoPreview=12025-05-08T15:00:00+00:002100.0Journal of Plasma PhysicsMicroinstabilities drive turbulent fluctuations in inhomogeneous, magnetized plasmas. In the context of magnetic confinement fusion devices, this leads to an enhanced transport of particles, momentum, and energy, thereby degrading confinement. In this work, we elaborate on the application of the adjoint method to efficiently determine the variation of linear growth rates for plasma microstabilities concerning a general set of external parameters within the local δf-gyrokinetic model. We then offer numerical verification of this approach. When coupled with gradient-based techniques, this methodology can facilitate the optimization process for the microstability of the confined plasmas across a high-dimensional parameter space. We present a numerical demonstration wherein the ion-temperature gradient (ITG) instability growth rate in a tokamak plasma is minimized with respect to flux surface shaping parameters. The adjoint method approach demonstrates a significant computational speed-up compared to a finite-difference gradient calculation.https://cassyni-user-files-prod.s3.amazonaws.com/S3WC4384T5ZBYzjf4QFam4 https://cassyni.com/slides/outline/BxFPEqqbVCL6AWhmHUMaN9 https://cassyni.com/events/BxFPEqqbVCL6AWhmHUMaN9/abstract https://cassyni-user-files-prod.s3.amazonaws.com/LrhM4rq3qmjjueGyULpVWv https://cassyni.com/events/BxFPEqqbVCL6AWhmHUMaN9?videoPreview=1 The surprising effectiveness of cosmic ray accelerationnohttps://cassyni.com/events/BxFPEqqbVCL6AWhmHUMaN9?videoPreview=12024-10-31T15:00:00+00:003147.08Journal of Plasma PhysicsIf I did not know better from observations I would say that cosmic rays could not be accelerated to multi-PeV energies in the Milky Way Galaxy or to energies of 100EeV beyond the Milky Way. Cosmic ray acceleration is basically a plasma process. I will examine the limits imposed by plasma physics and consider ways in which acceleration might be more effective than I at least would have expected.https://cassyni-user-files-prod.s3.amazonaws.com/LrhM4rq3qmjjueGyULpVWv https://cassyni.com/slides/outline/NKthKpwW7AtEqVhJb9EugH https://cassyni.com/events/NKthKpwW7AtEqVhJb9EugH/abstract https://cassyni-user-files-prod.s3.amazonaws.com/TK77WGwzn4QQZGSTYau6iJ https://cassyni.com/events/NKthKpwW7AtEqVhJb9EugH?videoPreview=1 PIC simulations of particle acceleration at relativistic magnetized shocksnohttps://cassyni.com/events/NKthKpwW7AtEqVhJb9EugH?videoPreview=12023-07-27T15:00:00+00:001909.88Journal of Plasma PhysicsThe efficiency of particle acceleration at shock waves in relativistic, magnetized astrophysical outflows is a debated topic with far-reaching implications. Most of previous numerical studies based on fully PIC simulations consider laminar in-flow conditions, i.e., nonturbulent, homogeneous background plasma of uniform magnetization. In this talk, based on a recent study, I will show how the presence of a well-developed turbulence upstream of a fast shock may change the picture. In particular, we carried out PIC simulations of a mildly relativistic magnetized pair shock (Lorentz factor γsh ≃ 2.7, magnetization level σ ≃ 0.01), and we found that strong turbulence can revive particle acceleration in a superluminal configuration that otherwise prohibits it. By the analysis of tracked particles we investigated the acceleration process and could conclude that, depending on the initial plasma temperature and magnetization, shock-drift or diffusive-type acceleration governs particle energization, producing power-law spectra dN/dγ ∝ γ^−s with s ≈ 2.5–3.5. At larger magnetization levels, stochastic acceleration within the preshock turbulence becomes competitive and can even take over shock acceleration.https://cassyni-user-files-prod.s3.amazonaws.com/TK77WGwzn4QQZGSTYau6iJ https://cassyni.com/slides/outline/NpYJNWb2YdSHqGECBaXhwb https://cassyni.com/events/NpYJNWb2YdSHqGECBaXhwb/abstract https://cassyni-user-files-prod.s3.amazonaws.com/PpayLxiCUX4NcnosSfoP4i https://cassyni.com/events/NpYJNWb2YdSHqGECBaXhwb?videoPreview=1 Fundamental Scaling of Adiabatic Compression of Field Reversed Configuration Thermonuclear Fusion Plasmasnohttps://cassyni.com/events/NpYJNWb2YdSHqGECBaXhwb?videoPreview=12022-12-08T16:00:00+00:003786.52Journal of Plasma PhysicsField Reversed Configuration (FRC) plasmas are plasma devices that have demonstrated that through magnetic compression can be heated to thermonuclear fusion conditions in the parameter space of an energy-producing generator. Of particular interest, FRCs are high-beta, in that the plasma particle kinetic energy is in balance with an externally applied magnetic field at all stages of operation. Dr. Kirtley will present the fundamental theory of FRC formation, scaling, and stability. A brief summary of experimental FRC programs dating to 1990 will be detailed. As will be presented, a cylindrical approximation for the energy and particle distribution within an FRC can, within 10%, match the fusion performance results of both full Magnetohydrodynamic (MHD) simulations as well as all robust, modern theoretical spatial and energy distribution models. Further, by using the cylindrical model, detailed fusion reaction, radiation, and energy transport equations are now numerically-tractable and can be modelled over a wide parameter space. A detailed numerical model will be presented with the key theoretical performance of the compression of high-beta fusion plasmas in both Deuterium-Tritium (D-T) and Deuterium-Helion (D-He-3) fuels. As will be shown, a high-beta D-He-3 plasma outperforms the traditional, low-beta D-T fuel and can theoretically yield a net-positive fusion generator.https://cassyni-user-files-prod.s3.amazonaws.com/PpayLxiCUX4NcnosSfoP4i https://cassyni.com/slides/outline/HPQerzUFibMDSPyxafXux9 https://cassyni.com/events/HPQerzUFibMDSPyxafXux9/abstract https://cassyni-user-files-prod.s3.amazonaws.com/JPTKqSbReUyJDvZdqkob5G https://cassyni.com/events/HPQerzUFibMDSPyxafXux9?videoPreview=1 Plasma Physics of Pulsar Magnetospheresnohttps://cassyni.com/events/HPQerzUFibMDSPyxafXux9?videoPreview=12022-07-07T15:00:00+00:004349.88Journal of Plasma PhysicsPulsars turn out to be much more complex than a seemingly simple rotating dipole field. The relativistic plasma required for current closure in their magnetospheres requires two signs of charge, so production of electron-positron pairs in required. A great deal of progress has been made over the last 15-20 years in understanding the structure of fields and currents in the pulsar magnetosphere. However, the source of the plasma and how the microphysics of its production is self-consistently coupled with the global magnetosphere is still not resolved. While we have determined that the main site of particle acceleration and high-energy radiation is in the current sheet outside the light cylinder, the details of the mechanisms involved are also not resolved. I will review the theoretical progress to date, from force-free MHD global models to particle-in-cell simulations. I will also review the recent ideas for generating the pulsar emission from radio to Very-High-Energy wavelengths that is ultimately needed to connect with observations.https://cassyni-user-files-prod.s3.amazonaws.com/JPTKqSbReUyJDvZdqkob5G https://cassyni.com/events/Vjcm25eNh3C5L5DmZ26e6H/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Cx1q4zouPUhYwWdyMkYsjC https://cassyni.com/events/YCrnFVsztKxZh1hL6i1GpD/abstract https://cassyni-user-files-prod.s3.amazonaws.com/FYRFZaxQh8c4ihSK2pke62 https://cassyni.com/events/TGNjnfQkVkRYHuyz6EJH65/abstract https://cassyni.com/events/816Az1BHNtpfXKwVAvhyPs/abstract https://cassyni.com/slides/outline/CRrx4ERL2JcJPi97V8YRxZ https://cassyni.com/events/CRrx4ERL2JcJPi97V8YRxZ/abstract https://cassyni-user-files-prod.s3.amazonaws.com/MA7z6t8oLh29mw6c2cE6pn https://cassyni.com/events/CRrx4ERL2JcJPi97V8YRxZ?videoPreview=1 Towards Equitable Access: Evaluating the Paediatric Interventional Radiology (PIR) Landscape in the Asia-Pacific Regionnohttps://cassyni.com/events/CRrx4ERL2JcJPi97V8YRxZ?videoPreview=12025-10-14T09:50:22+00:00652.32Society for Pediatric Interventional Radiology## Introduction To evaluate the current state of PIR workforce, opportunities and challenges in the Asia- Pacific (APAC) region. ## Materials and Methods A three-part electronic survey was distributed to members of the Society of Pediatric Interventional Radiology (SPIR), Asian Oceanian Society for Pediatric Radiology (AOSPR), and Asia-Pacific Society of Cardiovascular and Interventional Radiology (APSCVIR). Part 1 addressed individual provider practices, Part 2 focused on institutional service, and Part 3 assessed perceptions on priorities for developing PIR in APAC, with respondents rating the importance of different factors on a 10-point scale. ## Results A total of 116 individual and 100 institutional responses from 19 APAC countries/regions were analysed. Only 11.2% (13/116) individuals identified as paediatric interventional radiologists, while the majority (66.3%, 77/116) were adult interventional radiologists. Only 6.0% (7/116) reported performing PIR in &gt;50% of their clinical practice. Among the responding institutions, 28.0% (28/100) were children’s hospitals. Over half (52/100) have dedicated anaesthesia sessions for PIR. Common procedures included drainage (84%), biopsy (76%), vascular access (70%), and vascular anomaly treatment (70%). While all centres offered daytime PIR services, only 33.0% (33/100) provided on-call coverage. Among those, the majority (25/33) relied on a single PIR provider for on-call coverage. The highest-rated needs for PIR development were a specialist network for case discussion (mean score = 8.9), dedicated anaesthesia resources (8.7), and regional PIR training centres (8.5). ## Discussion PIR in the APAC region faces significant challenges in manpower and resource allocation. Strengthening structured training pathways and securing dedicated anaesthesia support are key to provide equitable PIR access across the region.https://cassyni-user-files-prod.s3.amazonaws.com/MA7z6t8oLh29mw6c2cE6pn https://cassyni.com/events/Uj1HZ88ftAYgQK3YTHTmTT/abstract https://cassyni-user-files-prod.s3.amazonaws.com/QuUR25BhYK8f41Deb7jJkE https://cassyni.com/slides/outline/SkdrHRffMDk6tBSJhgFCL5 https://cassyni.com/events/SkdrHRffMDk6tBSJhgFCL5/abstract https://cassyni-user-files-prod.s3.amazonaws.com/12sntQ4n6djVrsGRewgDkS https://cassyni.com/events/SkdrHRffMDk6tBSJhgFCL5?videoPreview=1 Maximizing the cost-effectiveness of relief prepositioning inventory and funding assurance strategy by integrating stockpiles, supply contract, and insurancenohttps://cassyni.com/events/SkdrHRffMDk6tBSJhgFCL5?videoPreview=12025-07-06T01:00:00+00:001288.32Risk SciencesRelief organizations face numerous challenges, such as funding shortfalls, delays in relief operations, and uncertain demand. A single prepositioning inventory strategy (e.g., stockpiles or supply contract) does not provide an effective solution to these challenges. Therefore, we propose a prepositioning inventory and funding assurance strategy that combines stockpiles, supply contracts with suppliers, and insurance agreements for relief organizations. A deterministic model for the proposed strategy is established along with the objective of maximizing cost-effectiveness. We establish two benchmark models: one combining stockpiles with supply contract and the other combining stockpiles with catastrophe insurance. Then, we compare the relief performance of maximizing cost-effectiveness with minimizing economic costs and minimizing social costs in the proposed strategy. Two-stage robust optimization models are established to address disaster uncertainties. The column-and-constraint generation algorithm is designed to solve robust models, and the Charnes–Cooper transform method is used to transform the fractional objective to an integrated objective. The results of two case studies in Dali and Zhaotong, China, show that the proposed strategy with maximizing cost-effectiveness leads to the acquisition of a moderate amount of insurance with options purchased in quantities that are larger than the stockpiles. Compared with the two benchmark strategies, the proposed strategy can improve cost-effectiveness and achieve cost reduction, especially in years with large disasters. In addition, the objectives of minimizing economic costs and social costs emphasize overly conservative prepositioning inventory and funding assurance strategies, while the optimization results of maximizing cost-effectiveness show robustness when facing disasters with various severities. This speech record is an excerpt from Professor Wang's keynote speech for the [Risk Sciences Colloquium – 2025 International Workshop on Risk Sharing (IWRS)](https://www.keaipublishing.com/en/journals/risk-sciences/event/2025-international-workshop-on-risk-sharing-iwrs/) , which was held on July 6-7, 2025, in Beijing, China. This video is categorized under ***Catastrophe Risk Sharing***.https://cassyni-user-files-prod.s3.amazonaws.com/12sntQ4n6djVrsGRewgDkS https://cassyni.com/slides/outline/Wha5dECtEdqLwUwkF2e6n1 https://cassyni.com/events/Wha5dECtEdqLwUwkF2e6n1/abstract https://cassyni-user-files-prod.s3.amazonaws.com/2ad9rHwzd7xmj6o5FGAHZ8 https://cassyni.com/events/Wha5dECtEdqLwUwkF2e6n1?videoPreview=1 Episode 11: A Conversation with Ellen Lavoie Smithnohttps://cassyni.com/events/Wha5dECtEdqLwUwkF2e6n1?videoPreview=12026-02-18T09:00:00+00:001913.04Advanced ScienceChemotherapy-induced peripheral neuropathy (CIPN) represents a significant challenge in cancer care, often leading to severe symptoms and poor quality of life, with historical limitations in effective interventions. Research on CIPN has been inspired by complex patient cases, highlighting the influence of individual experiences and social determinants of health on neuropathic pain. Early studies identified duloxetine as the first effective treatment for established painful CIPN in 30 years. However, a subsequent multi-site randomized controlled Phase 2 study investigating duloxetine for CIPN prevention observed a high placebo response rate when solely relying on patient-reported outcomes (PROs), indicating their vulnerability to subjective effects. Current efforts focus on developing more robust assessment and treatment strategies. An ongoing international study is employing a multimodal approach, integrating validated and novel PROs with objective physiological measures and a panel of serum biomarkers, including neurofilament light chain (NFL), as a potential indicator of axonal injury. Complementary research explores non-opioid interventions, such as green tea extract, tested in an animal model of oxaliplatin-induced neuropathy. The study also acknowledges patient heterogeneity, investigating how social determinants of health, such as access to healthy food and safe exercise environments, may influence treatment responses. Future directions aim to bridge the disconnect between subjective patient experiences and objective findings through comprehensive data collection and advanced analytical techniques, including machine learning, to develop more targeted and personalised CIPN management strategies.https://cassyni-user-files-prod.s3.amazonaws.com/2ad9rHwzd7xmj6o5FGAHZ8 https://cassyni.com/slides/outline/34Ve4eeVNsajYd2Nz1rYNR https://cassyni.com/events/34Ve4eeVNsajYd2Nz1rYNR/abstract https://cassyni-user-files-prod.s3.amazonaws.com/8afehrWQVVWHfT4kWNHKT4 https://cassyni.com/events/34Ve4eeVNsajYd2Nz1rYNR?videoPreview=1 Vibrating cables & flapping flags: classical fluid-solid instabilities or energy sourcesnohttps://cassyni.com/events/34Ve4eeVNsajYd2Nz1rYNR?videoPreview=12017-04-27T10:30:00+00:003853.08UK Fluids NetworkThe coupling of engineering structures with the wind or water currents flowing around them can generate so-called flow-induced vibrations, resulting in periodic and often large solid displacements and deformations. Until recently, such vibrations have been mostly studied from a control or stability point of view, to avoid or mitigate the resulting structural damage and fatigue. Yet recently, a new light is being shed on such fluid-solid interactions (FSI) as potential energy harvesting mechanisms to exploit the underlying energy transfer to power a generator. Here, we will present some of our recent work on two classical FSI problems (vortex-induced vibration of flexible cables and flapping flexible flags) as energy harvesting systems, highlighting fundamental principles regarding the efficiency of such systems and their optimisation.https://cassyni-user-files-prod.s3.amazonaws.com/8afehrWQVVWHfT4kWNHKT4 https://cassyni.com/slides/outline/PJf5FESiLEPajBHgGKsqVP https://cassyni.com/events/PJf5FESiLEPajBHgGKsqVP/abstract https://cassyni-user-files-prod.s3.amazonaws.com/BiP5SXMzhNJmVMAnXTUv94 https://cassyni.com/events/PJf5FESiLEPajBHgGKsqVP?videoPreview=1 High Order Semi-Implicit Asymptotic and Structure Preserving Schemes for Compressible Viscous Flowsnohttps://cassyni.com/events/PJf5FESiLEPajBHgGKsqVP?videoPreview=12022-10-17T14:00:00+00:003255.92Journal of Computational PhysicsIn the first part of this talk we introduce a high order pressure-based solver for the solution of the 3D compressible Navier-Stokes system at all Mach numbers. We propose a cell-centered discretization of the governing equations that splits the fluxes into a fast and a slow scale part, that are treated implicitly and explicitly, respectively. A novel semi-implicit discretization is proposed for the kinetic energy as well as the enthalpy fluxes in the energy equation, hence avoiding any need of iterative solvers. The implicit discretization yields an elliptic equation on the pressure that can be solved for both ideal gas and general equation of state (EOS). A nested Newton method is used to solve the mildly nonlinear system for the pressure in case of nonlinear EOS. High order in time is granted by implicit-explicit (IMEX) time stepping, whereas a novel CWENO technique efficiently implemented in a dimension-by-dimension manner is developed for achieving high order in space for the discretization of explicit convective and viscous fluxes. A quadrature-free finite volume solver is then derived for the high order approximation of numerical fluxes. Central schemes with no dissipation of suitable order of accuracy are finally employed for the numerical approximation of the implicit terms. Consequently, the CFL-type stability condition on the maximum admissible time step is based only on the fluid velocity and not on the sound speed, so that the novel schemes work uniformly for all Mach numbers. The schemes are proven to be asymptotic preserving in the low Mach limit of the governing equations. The second part of the talk is concerned with an implicit discretization of the viscous terms. A variational approach based on the discontinuous Galerkin (DG) spatial discretization is devised in order to obtain a discrete cell-centered Laplace operator. High order corner gradients of the velocity field are employed in 3D to derive the Laplace discretization, and the resulting viscous system is proven to be symmetric and positive definite. The last part of the talk is devoted to the design of a novel Structure-Preserving Discontinuous Galerkin (SPDG) operator that recovers at the discrete level the algebraic property related to the divergence of the curl of a vector field, which is typically referred to as div-curl problem. A staggered Cartesian grid is adopted in 3D, where the vector field is naturally defined at the corners of the control volume, while its curl is evaluated as a cell-centered quantity. We demonstrate that the novel SPDG schemes are capable of obtaining a zero div-curl identity with machine precision from second up to sixth order accuracy. Finally, we show the applicability of these SPDG methods by solving the incompressible Navier-Stokes equations written in vortex-stream formulation. Convergence and robustness of the proposed method are assessed through a wide set of benchmark problems involving low and high Mach number regimes, as well as inviscid and viscous flows.https://cassyni-user-files-prod.s3.amazonaws.com/BiP5SXMzhNJmVMAnXTUv94 https://cassyni.com/slides/outline/WiP8wV9av6hRDkp9ECjZuP https://cassyni.com/events/WiP8wV9av6hRDkp9ECjZuP/abstract https://cassyni-user-files-prod.s3.amazonaws.com/7dtYaNoAKnj1k6Zfa92kDL https://cassyni.com/events/WiP8wV9av6hRDkp9ECjZuP?videoPreview=1 Time-modulated composites: some recent results on field-pattern materialsnohttps://cassyni.com/events/WiP8wV9av6hRDkp9ECjZuP?videoPreview=12022-11-01T14:00:00+00:003745.28MetaMATField patterns are a new type of wave propagating in one-dimensional linear media with moduli that vary both in space and time [1, 2, 3]. Specifically, the geometry of these space-time materials is commensurate with the slope of the characteristic lines so that a disturbance does not generate a complicate cascade of subsequent disturbances, but rather concentrates on a periodic space-time pattern, that we call field pattern. Field patterns present spectacularly novel features. One of the most interesting ones is the appearance of a wave generated from an instantaneous source, whose amplitude, unlike a conventional wake, does not tend to zero away from the wave front. Furthermore, when the parameters of the material are suitably chosen, so that the condition of PT-symmetry is unbroken, the wavefront propagates maintaining the same amplitude. This is particularly remarkable if one observes that, due to the instantaneous time modulation, energy is not conserved but it increases exponentially in time. In this talk, we will explain how stable modes that do not blow up in time, even though the associated energy does, can be generated by suitably designing the spatial geometry of the composite, which must be related to the periodicity of the time modulation as well as the material properties. We will start from the classical results for the one-dimensional case, obtained in [1, 2, 3] in collaboration with Graeme W. Milton. Then, we will extend such design concepts to the two dimensional case and show the most recent results obtained in collaboration with Vincenzo Gulizzi.https://cassyni-user-files-prod.s3.amazonaws.com/7dtYaNoAKnj1k6Zfa92kDL https://cassyni.com/slides/outline/8VCwrj2yAVmxREzyFg46wf https://cassyni.com/events/8VCwrj2yAVmxREzyFg46wf/abstract https://cassyni-user-files-prod.s3.amazonaws.com/QwoziAJTiaRRiawTC5acDt https://cassyni.com/events/8VCwrj2yAVmxREzyFg46wf?videoPreview=1 Willis couplings in one-dimensional and quasi-one-dimensional acoustic systemsnohttps://cassyni.com/events/8VCwrj2yAVmxREzyFg46wf?videoPreview=12022-11-15T14:00:00+00:003974.08MetaMATSince the seminal work of Willis in the 80’s, the eponymous materials have received an increasing attention, because of their analogy with bi-isotropic/anisotropic electromagnetic metamaterials. The Willis coupling parameters couple the potential and kinetic energy in the acoustic conservation relations, therefore enhancing the ability to control waves in metamaterials compared to other materials that do not exhibit such coupling. In this talk, I will present a general method to derive the closed form expressions of the effective properties, including the Willis coupling, of asymmetric and nonreciprocal one dimensional acoustic systems. This method relies on the Pade’s approximation of the matrix exponential, the latter being nothing but the transfer matrix that may relate the state vectors at both sides of a unit cell. The effective properties of various one-dimensional asymmetric resonant systems are first derived, numerically and experimentally validated, and analyzed. The nonlocal feature of the Willis coupling is then investigated in a simple fluid laminate system. The asymmetric and nonreciprocal Willis couplings are finally analytically derived and discussed in a system constituted of a periodic arrangement of thermoacoustic amplifiers. https://cassyni-user-files-prod.s3.amazonaws.com/QwoziAJTiaRRiawTC5acDt https://cassyni.com/events/DS7L31EWbVDA58KX17oS3w/seminar/qa https://cassyni.com/slides/outline/DS7L31EWbVDA58KX17oS3w https://cassyni.com/events/DS7L31EWbVDA58KX17oS3w/abstract https://cassyni-user-files-prod.s3.amazonaws.com/YP4nutxw7tWcMmHu9DJ2vJ https://cassyni.com/events/DS7L31EWbVDA58KX17oS3w?videoPreview=1 New Phytologist Now - Tansley Medal winner Anna Trugmannohttps://cassyni.com/events/DS7L31EWbVDA58KX17oS3w?videoPreview=12022-10-06T16:00:00+00:002161.16New PhytologistIntegrating plant physiology and community ecology across scales through trait-based models to predict drought mortality Forests are a critical carbon sink and widespread tree mortality resulting from climate-induced drought stress has the potential to alter forests from a carbon sink to a source, causing a positive feedback on climate change. Process-based vegetation models aim to represent the current understanding of the underlying mechanisms governing plant physiological and ecological responses to climate. Yet model accuracy varies across scales, and regional-scale model predictive skill is frequently poor when compared with observations of drought-driven mortality. Anna proposes a framework that leverages differences in model predictive skill across spatial scales, mismatches between model predictions and observations, and differences in the mechanisms included and absent across models to advance the understanding of the physiological and ecological processes driving observed patterns drought-driven mortality. Hosted by New Phytologist Editor Nate McDowell Banner image by David Tip on Unsplash https://cassyni-user-files-prod.s3.amazonaws.com/YP4nutxw7tWcMmHu9DJ2vJ https://cassyni.com/events/LqR41pD68wd6NEp7idyCmT/abstract https://cassyni-user-files-prod.s3.amazonaws.com/6xfVuqiytG5A6MsWRYyLmC https://cassyni.com/events/XD4N6oJzkvBF3Dof2JrY5b/seminar/qa https://cassyni.com/slides/outline/XD4N6oJzkvBF3Dof2JrY5b https://cassyni.com/events/XD4N6oJzkvBF3Dof2JrY5b/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Y4QzpSNkT7JyumDqQy48ZC https://cassyni.com/slides/outline/Kr7qvSv3G2WwhUz7cfVsxZ https://cassyni.com/events/Kr7qvSv3G2WwhUz7cfVsxZ/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Enu1NH6QeiLqRh8PyQtEiS https://cassyni.com/events/Kr7qvSv3G2WwhUz7cfVsxZ?videoPreview=1 DNS investigation of turbulence transition of NACA0012 at near post-stall regimenohttps://cassyni.com/events/Kr7qvSv3G2WwhUz7cfVsxZ?videoPreview=12022-09-15T08:30:00+00:001704.92NEKTAR++Stall and post-stall conditions occur in different modern engineering settings, such as compressors and turbines in gas engines and wind turbines to name a few. To be able to design such components a detailed understanding of the complex flow physics generally encountered in these cases is required. Separation, turbulent transition, shear layers are an example of some of the intricate flow behaviour that may appear. In this work, an extensive Direct Numerical Simulation study of the solution at angles of attack 9, 10 and 12 degrees will be carried out. Similar flow features will be seen, but their location and intensity differs as the aerofoil is tilted more and more. Boundary layer quantities will be computed to assess the situation and the difference between the cases. Following this, an in-depth analysis of the effects of the mesh resolution, but in particular, of the spatial discretisation scheme will be carried out. The evidence suggests a very strong dependency on the small scale behaviour that mainly effects the leading edge bubble separation. Finally, a separate study will be carried out to understand the effects of the spanwise extrusion on the overall solution. The 10 degrees angle of attack case displayed a non-negligible dependency at both the leading edge and downstream of the 50% chord position. It is not conclusive as to whether the widest case (Lz=8) was sufficient to capture the entire flow physics. The 12 degree case, on the other hand, demonstrated that there is a much smaller dependency on the spanwise length.https://cassyni-user-files-prod.s3.amazonaws.com/Enu1NH6QeiLqRh8PyQtEiS https://cassyni.com/events/WDjXtoW4Ue9NDzHFdmSme5/abstract https://cassyni-user-files-prod.s3.amazonaws.com/51yQmGjYE1rfZoeALvXHbC https://cassyni.com/events/WDjXtoW4Ue9NDzHFdmSme5?videoPreview=1 Research Ideas Worth Funding III - Panel discussionnohttps://cassyni.com/events/WDjXtoW4Ue9NDzHFdmSme5?videoPreview=12022-10-27T21:00:00+00:007279.88Faculty of Business and EconomicsThis is the Business School Health and Well-being Research Beacon’s third transdisciplinary research ideas event (RIWF III) for all those interested in connecting and collaborating under the Beacon’s theme. In this panel discussion, leading researchers across a number of disciplines and faculties come together to discuss ideas for research and transdisciplinary collaboration on ‘Future of well-being’ and ‘Infusing cultural intelligence in healthcare’. There is unprecedented demand for multi-disciplinary work in the field of health and well-being which combines medicine, both physical and mental, as well as health management and psychological aspects of the social sciences. Our work in this domain is inspired by the notion of co-creation of policy frameworks and public-policy debates, on the basis of solid empirical research. We hope that this will trigger further thoughts and conversations and unveil shared research interests that you may want to explore further.https://cassyni-user-files-prod.s3.amazonaws.com/51yQmGjYE1rfZoeALvXHbC https://cassyni.com/slides/outline/71HkqJcHFV3LsY3p6XZEfF https://cassyni.com/events/71HkqJcHFV3LsY3p6XZEfF/abstract https://cassyni-user-files-prod.s3.amazonaws.com/NMdZVvzrHHRAGyXUmdncvi https://cassyni.com/events/71HkqJcHFV3LsY3p6XZEfF?videoPreview=1 Two-photon fluorescence lifetime imaging applied to the measurement of the droplet temperature in sprays, Measurement of instantaneous fully 3D scalar dissipation rate in a turbulent swirling flownohttps://cassyni.com/events/71HkqJcHFV3LsY3p6XZEfF?videoPreview=12023-02-21T15:00:00+00:003460.08Experiments in FluidsDroplets temperature is a key parameter for the study of heat and mass transfers in many spray applications. Time correlated single photons counting (TCSPC) is applied to monitor the fluorescence decay and determine the droplet temperature in the mixing zone of two sprays which are injected with significantly different temperatures. For some well-chosen fluorescent dye, like rhodamine B (RhB), the fluorescence lifetime strongly varies with the temperature. Provided sufficiently different fluorescence lifetimes for the droplets of the two sprays, the fluorescence decay is expected to follow a multiple exponential decay. In this study, different approaches are tested for measuring the temperature of the two sprays as well as their mixing fraction based on the analysis of the fluorescence decay. Firstly, the measurement of the mixture fraction alone is tested by considering a configuration where one spray is seeded with eosin Y (EY) and the other with rhodamine 6G (Rh6G). Given the very different lifetimes of these dyes, which are not temperature dependent, the fluorescence decay is function of the volume fraction of liquid from each spray in these tests. A calibration is necessary to evaluate the mixing fraction. Both sprays are mounted on an automated platform allowing 3D scanning and motions which allows obtaining maps of the fluorescence decay. The out-of-field fluorescence, observed in dense sprays when fluorescence is induced by one-photon absorption, is suppressed by using a two-photon fluorescence excitation. This approach significantly improves the spatial resolution of the measurements. Finally, both the droplet temperature and the mixing fraction are measured simultaneously using a single dye, namely RhB, whose fluorescence lifetime is temperature dependent. Special care must be paid to the fact that RhB does not have a purely monoexponential decay at a given temperature. The fluorescence decay in the mixing zone of the two sprays is considered as a combination of two biexponentials. Results show that the volume fraction of a spray must exceed about 10% to make it possible to determine its temperature with an accuracy of about 2–3 °C. Simultaneous measurements of the sprays temperatures and volume fractions provide a means to calculate the mixing temperature (the average between the temperatures of the two sprays weighted by their volume fractions). This paper describes the measurement methodology for quantifying the instantaneous full 3D scalar dissipation rate (SDR) in order to characterize the rate of mixing. Measurements are performed in a near field of a jet-in-swirling-coflow configuration. All three components of SDR are measured using a dual-plane acetone planar laser-induced fluorescence technique. To minimize noise, a Wiener filtering approach is used. The out-of-plane SDR component is validated by assuming isotropy between axial and azimuthal components of SDR. An optimum laser-sheet separation distance is identified by comparing the SDR components on the basis of instantaneous, mean, and probability density function data. The in-plane resolution needs to match the Batchelor scale for the central difference scheme-based SDR deduction. However, the out-of-plane resolution requirement is different owing to the use of two-point difference based SDR and systematic biases. The optimum out-of-plane resolution is found to be 2.5xBatchelor scale. Finally, measurement guidelines are provided to assess the accuracy of 3D SDR measurements.https://cassyni-user-files-prod.s3.amazonaws.com/NMdZVvzrHHRAGyXUmdncvi https://cassyni.com/events/GPcEiHuFbBZcjHWx1f2oXs/seminar/qa https://cassyni.com/slides/outline/GPcEiHuFbBZcjHWx1f2oXs https://cassyni.com/events/GPcEiHuFbBZcjHWx1f2oXs/abstract https://cassyni-user-files-prod.s3.amazonaws.com/QPDdkeKoN6E65JYaJQ4Ym4 https://cassyni.com/events/GPcEiHuFbBZcjHWx1f2oXs?videoPreview=1 12 Labours Seminar Series: A multiscale modelling framework for computational physiologynohttps://cassyni.com/events/GPcEiHuFbBZcjHWx1f2oXs?videoPreview=12023-04-05T00:00:00+00:003969.2Auckland Bioengineering InstituteThere is much interest from the bioengineering healthcare community worldwide in the concept of a whole-body "digital twin" computational model that can be personalised and linked with data from clinical imaging and hospital-based functional measurements, as well as from a variety of wearable, implantable or home-based devices. To be effective this is going to require a new much more comprehensive and integrative approach to computational physiology. Models of subcellular biology that can take advantage of tissue biomarkers (blood, urine, etc) must be linked with measurements of genotype and included in models of higher-level physiological function at the tissue and organ scale. Surrogate (via machine learning) organ models must be included in organ systems and integrated into whole-body models that include autonomic neural and endocrine control. This talk will discuss the mathematical framework for an algorithmic energy-based approach to multiscale computational physiology that lends itself to crowd-sourcing the international effort needed to tackle the demanding requirements of a "digital" or "virtual" twin for healthcare. https://cassyni-user-files-prod.s3.amazonaws.com/QPDdkeKoN6E65JYaJQ4Ym4 https://cassyni.com/slides/outline/YCkHnypTGtFf7QVZvGrqWu https://cassyni.com/events/YCkHnypTGtFf7QVZvGrqWu/abstract https://cassyni-user-files-prod.s3.amazonaws.com/DtQyiPoFT21Tpit5q5q3h8 https://cassyni.com/events/YCkHnypTGtFf7QVZvGrqWu?videoPreview=1 Circular market systems in the makingnohttps://cassyni.com/events/YCkHnypTGtFf7QVZvGrqWu?videoPreview=12022-11-02T01:00:00+00:001907.64Department of MarketingThe circular economy (CE) – a new paradigm that encourages system thinking and innovation to reduce waste, increase resource efficiency, and keep materials in use – is gaining momentum in academic and managerial discourse (e.g., Bocken et al., 2016). Marketing scholars have developed a growing body of knowledge to support a shift in perspective from linear to circular business. Yet, while circular markets are critical for circular business to work, very few CE studies explicitly discuss markets and their making. Our systematic literature review revealed seven fields with implicit insights relevant to circular markets: circular business models, product-service systems, circular supply chains, industrial symbiosis, pro-circular customer behavior, eco-innovation, and technology infrastructure. To integrate these literatures, we used the guiding principles of market practices, which resulted in a new framework of circular market systems. This framework advances understanding of the CE at the nexus of sustainability, markets, and marketing, and offers integrative guideposts for future research. https://cassyni-user-files-prod.s3.amazonaws.com/DtQyiPoFT21Tpit5q5q3h8 https://cassyni.com/slides/outline/15UtAUL6adUSfCp4hWSUVb https://cassyni.com/events/15UtAUL6adUSfCp4hWSUVb/abstract https://cassyni-user-files-prod.s3.amazonaws.com/U8pTZrE8sKKAGcZwB8zFaN https://cassyni.com/events/15UtAUL6adUSfCp4hWSUVb?videoPreview=1 Nonlinear interaction of the self-sustaining process in the near-wall region of wall-bounded turbulencenohttps://cassyni.com/events/15UtAUL6adUSfCp4hWSUVb?videoPreview=12021-06-11T15:00:00+00:001716.68Journal of Fluid MechanicsWe investigate the nonlinear interaction in the self-sustaining process of wall-bounded turbulence. Resolvent analysis is used to identify the principal forcing (nonlinear) mode which produces the maximum amplification in direct numerical simulations of the minimal channel for the buffer layer. The identified mode is then removed from the nonlinear term of the Navier-Stokes equations at each time step from a direct numerical simulation of a minimal channel. The results show that the removal of the principal forcing mode is able to inhibit turbulence in the buffer layer, while the removal of subsequent modes only marginally affects the flow. Analysis of the dyadic interactions in the nonlinear term shows that contributions toward the principal forcing mode come from a limited number of wavenumber interactions. Using conditional averaging, the flow structures that are responsible for generating the principal forcing mode, and thus the nonlinear interaction to self-sustain turbulence, are identified to be spanwise rolls interacting with meandering streaks.https://cassyni-user-files-prod.s3.amazonaws.com/U8pTZrE8sKKAGcZwB8zFaN https://cassyni.com/slides/outline/3YiuPtZimvEw29HdFCM7DX https://cassyni.com/events/3YiuPtZimvEw29HdFCM7DX/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Nhgp4L7N3HDiTzDvFQrdLi https://cassyni.com/events/3YiuPtZimvEw29HdFCM7DX?videoPreview=1 Fingers, fractals, and flow in liquid metalsnohttps://cassyni.com/events/3YiuPtZimvEw29HdFCM7DX?videoPreview=12021-01-22T16:00:00+00:003314.0Journal of Fluid MechanicsA droplet of pure water placed on a clean glass surface will spread axisymmetrically, and a droplet of mercury will bead up into a spherical droplet. In both cases, the droplet is minimizing its surface energy -- creating an object with a minimized surface area -- and there is nothing to break the symmetry. Remarkably, droplets of the room-temperature liquid gallium-indium (EGaIn), which like all metals have an enormous surface tension, can nonetheless undergo fingering instabilities in the presence of an oxidizing voltage. I will describe how this oxide acts like a reversible surfactant, generating fingering instabilities, tip-splitting, and even fractals, through Marangoni instabilities. Remarkably, we find that EGaIn droplets placed in an electrolyte under an applied voltage can achieve near-zero surface tension. This effect can in turn be used to suppress the Rayleigh-Plateau instability in falling streams. Quantitative control of these effects provides a new route for the development of reconfigurable electronic, electromagnetic, and optical devices that take advantage of the metallic properties of liquid metals.https://cassyni-user-files-prod.s3.amazonaws.com/Nhgp4L7N3HDiTzDvFQrdLi https://cassyni.com/slides/outline/Ftw1YyjqkN5nupXSDYuqMf https://cassyni.com/events/Ftw1YyjqkN5nupXSDYuqMf/abstract https://cassyni-user-files-prod.s3.amazonaws.com/VDQdojLswkohfQZBqpbnVt https://cassyni.com/events/Ftw1YyjqkN5nupXSDYuqMf?videoPreview=1 Spectral and Topological Engineering with Space Groupsnohttps://cassyni.com/events/Ftw1YyjqkN5nupXSDYuqMf?videoPreview=12022-07-05T08:30:00+00:001977.04ETOPIMI will first introduce a variety of metamaterials that are designed by acting with the elements of a space group on one or several master resonators of given shapes and internal structures. The result is a metamaterial with a rich resonant spectral structure carrying a large number of topological gaps. Furthermore, aperiodic perturbations enrich the metamaterials with a phason that lives on exotic manifolds such as the Klein bottle. In the second part of the talk, I will describe how to identify the topological labels of the gaps and how to generate interesting bulk-boundary and bulk-defect correspondences.https://cassyni-user-files-prod.s3.amazonaws.com/VDQdojLswkohfQZBqpbnVt https://cassyni.com/slides/outline/AToN3Td4vKziWxHCcdv3ND https://cassyni.com/events/AToN3Td4vKziWxHCcdv3ND/abstract https://cassyni-user-files-prod.s3.amazonaws.com/6s3RMAoVgRqE7cXSN1JaTG https://cassyni.com/slides/outline/AxSy69GbMnYmWip6D5CqdX https://cassyni.com/events/AxSy69GbMnYmWip6D5CqdX/abstract https://cassyni-user-files-prod.s3.amazonaws.com/2AJ71TLQ41838cHFyKfoaW https://cassyni.com/events/AxSy69GbMnYmWip6D5CqdX?videoPreview=1 Bloch surface waves on a fiber tipnohttps://cassyni.com/events/AxSy69GbMnYmWip6D5CqdX?videoPreview=12022-07-08T10:10:00+00:00805.04ETOPIMWe present a nano-optical platform based on Bloch surface waves (BSWs) which covers the cleaved end facet of a multicore optical fiber and we demonstrate a multiplexing application. The platform is interfaced with the fiber cores using specially designed subwavelength gratings. A 16% coupling efficiency between fiber modes and BSWs is measured. Interconnecting various fiber cores and BSWs directly at the end of a multicore fiber opens the perspective of highly compact complex optical functionalities for the design of “smart fiber”. In counterpart, optical fibers provide a unique opportunity to obtain turnkey nano-optical functions addressing a vast application domain ranging from telecommunications to medical sensing.https://cassyni-user-files-prod.s3.amazonaws.com/2AJ71TLQ41838cHFyKfoaW https://cassyni.com/events/HsZ3rLqpuZEHA1W4s5iDQq/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Q4UDwD94FHjz4hnUee75La https://cassyni.com/slides/outline/LLo55m5T6qzmWwydQmcr8m https://cassyni.com/events/LLo55m5T6qzmWwydQmcr8m/abstract https://cassyni-user-files-prod.s3.amazonaws.com/4UcRjVGTeywQ4i6SeoJqLi https://cassyni.com/events/LLo55m5T6qzmWwydQmcr8m?videoPreview=1 Prolate wave operator and Zetanohttps://cassyni.com/events/LLo55m5T6qzmWwydQmcr8m?videoPreview=12022-05-06T16:10:00+00:003652.04Acta Scientiarum MathematicarumI will explain in my talk the recent work with Henri Moscovici on the link, in the ultraviolet regime, between the spectrum of a natural self-adjoint extension of the classical prolate wave operator and the squares of zeros of the Riemann zeta function.https://cassyni-user-files-prod.s3.amazonaws.com/4UcRjVGTeywQ4i6SeoJqLi https://cassyni.com/slides/outline/UjpLsP5NZdQkgHL6UcwuMf https://cassyni.com/events/UjpLsP5NZdQkgHL6UcwuMf/abstract https://cassyni-user-files-prod.s3.amazonaws.com/BUMqzuVbUkQR4bjFH7iDRx https://cassyni.com/events/UjpLsP5NZdQkgHL6UcwuMf?videoPreview=1 Unsteady Pressure-Sensitive Paint and Its Application to Transonic Buffet Studiesnohttps://cassyni.com/events/UjpLsP5NZdQkgHL6UcwuMf?videoPreview=12022-12-20T15:00:00+00:003608.96Experiments in FluidsUnsteady Pressure-Sensitive Paint (PSP) is an emerging technique that can measure pressure fields with high spatio-temporal resolution. Since the luminescence intensity of the PSP layer depends on oxygen partial pressure, the surface pressure can be calculated from the measured luminescence intensity. This seminar will cover the fundamentals of unsteady PSP, including principle, theoretical background, paint formulation, system requirements, and data reduction. Experimental results of applying unsteady PSP to transonic buffet of a 3-D swept wing will also be presented. From unsteady PSP measurements, characteristic pressure fluctuations known as "buffet cells" were extracted and their relationship to the onset of buffet was clarified. This experiment demonstrates the high capability and usefulness of unsteady PSP and related data reduction techniques.https://cassyni-user-files-prod.s3.amazonaws.com/BUMqzuVbUkQR4bjFH7iDRx https://cassyni.com/slides/outline/6We9ncxkp2VHsmWvW6GSPw https://cassyni.com/events/6We9ncxkp2VHsmWvW6GSPw/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Lmkmy2RQonrZ4uuTSL7zZU https://cassyni.com/events/6We9ncxkp2VHsmWvW6GSPw?videoPreview=1 Asymptotic windings of the block determinants of a unitary Brownian motion and related diffusionsnohttps://cassyni.com/events/6We9ncxkp2VHsmWvW6GSPw?videoPreview=12021-03-25T16:00:00+00:002399.12DataSıgWe study several matrix diffusion processes constructed from a unitary Brownian motion. In particular, we use the Stiefel fibration to lift the Brownian motion of the complex Grass- mannian to the complex Stiefel manifold and deduce a skew-product decomposition of the Stiefel Brownian motion. As an application, we prove asymptotic laws for the determinants of the block entries of the unitary Brownian motionhttps://cassyni-user-files-prod.s3.amazonaws.com/Lmkmy2RQonrZ4uuTSL7zZU https://cassyni.com/slides/outline/8ytB23CP1KG6yFL3TVRB5o https://cassyni.com/events/8ytB23CP1KG6yFL3TVRB5o/abstract https://cassyni-user-files-prod.s3.amazonaws.com/DpqBwHkYrCVoxjA8WvXFB4 https://cassyni.com/events/8ytB23CP1KG6yFL3TVRB5o?videoPreview=1 Celebrating the launch of Nature Water - Part 3: Focus on social sciences and open sciencenohttps://cassyni.com/events/8ytB23CP1KG6yFL3TVRB5o?videoPreview=12023-02-02T13:00:00+00:004569.72Nature WaterTo celebrate the launch of Nature Water, we have organized a series of webinars with some of the authors from the first issue. In this third webinar, editor Fabio Pulizzi will be talking to Julia Martin-Ortega about the role of social sciences in water research and with Rhea Verbeke and Stanislaus Schymanski about open science https://cassyni-user-files-prod.s3.amazonaws.com/DpqBwHkYrCVoxjA8WvXFB4 https://cassyni.com/slides/outline/Euh3gsUZgAq1BaZnrWXwFT https://cassyni.com/events/Euh3gsUZgAq1BaZnrWXwFT/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Jn3RjpLeMdc7diXPAQpYs8 https://cassyni.com/events/Euh3gsUZgAq1BaZnrWXwFT?videoPreview=1 Combustion in inert porous media: using DNS and experiments to address modelling challengesnohttps://cassyni.com/events/Euh3gsUZgAq1BaZnrWXwFT?videoPreview=12023-05-02T14:00:00+00:003110.04Experiments in FluidsCombustion in inert porous media (PMC) is a sub-category of combustion with heat recirculation and despite being a fairly old topic, it has seen renewed attention in the last decade. The main advantages of PMC are increased consumption rates and flammability ranges with very low emissions. In this talk, I will present recent work aiming at a better understanding of the flame structure at the pore level. Recent Direct Numerical Simulations and a new experimental technique will be presented in order to guide modelling of the flame in Volume Averaged Models. https://cassyni-user-files-prod.s3.amazonaws.com/Jn3RjpLeMdc7diXPAQpYs8 https://cassyni.com/events/6XNLkzMoHQaBgBdMvrfvp5/abstract https://cassyni-user-files-prod.s3.amazonaws.com/GFko81VPkTCpGmwF7BAAmU https://cassyni.com/events/GQLRgfJJ4ZeWXhdPSRSHx1/seminar/qa https://cassyni.com/slides/outline/GQLRgfJJ4ZeWXhdPSRSHx1 https://cassyni.com/events/GQLRgfJJ4ZeWXhdPSRSHx1/abstract https://cassyni-user-files-prod.s3.amazonaws.com/KMaW7VwXtFbJfzEKGMJfgi https://cassyni.com/events/GQLRgfJJ4ZeWXhdPSRSHx1?videoPreview=1 Responsive Hydrogels: Perspectives, Modelling, and Ongoing Effortsnohttps://cassyni.com/events/GQLRgfJJ4ZeWXhdPSRSHx1?videoPreview=12024-10-11T15:00:00+00:004077.04Journal of Fluid MechanicsHydrogels are hydrophilic polymer scaffolds surrounded by adsorbed water. From a dry state, they are capable of swelling in volume by up to two orders of magnitude – becoming up to 99% water - whilst still remaining solid (if a little squishy). Responsive hydrogels lose this affinity for water – sometimes quite profoundly – when an environmental stimulus, such as temperature or pH, transitions beyond a critical value. Conformational changes in the scaffold squeeze the water out, and the gel shrivels dramatically. This volume change is reversible (albeit non-reciprocal), allowing for cycles of activation and deactivation. As such, responsive hydrogels have important and exciting applications in microscale actuators. This talk will describe some of the big open areas of hydrogel modelling, before detailing two (very) recent unpublished theoretical pieces of work on 1) thermoresponsive displacement pumps for microfluidic devices, and 2) coupling pH-responsive gels to oscillating reactions to enable communication and synchronisation.https://cassyni-user-files-prod.s3.amazonaws.com/KMaW7VwXtFbJfzEKGMJfgi https://cassyni.com/slides/outline/8zcMzQbRUhLzmfSUtFpfVw https://cassyni.com/events/8zcMzQbRUhLzmfSUtFpfVw/abstract https://cassyni-user-files-prod.s3.amazonaws.com/PGFYXtrLLvzCfGCgdmZ8KG https://cassyni.com/events/8zcMzQbRUhLzmfSUtFpfVw?videoPreview=1 Inclusive Wireless Technologies for Independence and Participationnohttps://cassyni.com/events/8zcMzQbRUhLzmfSUtFpfVw?videoPreview=12021-05-15T10:00:00+00:00841.44 School of Public PolicyDr. Nathan Moon discusses inclusive wireless technologies and how they can support the independence and community participation of people with disabilities -- from smartphones and tablets to wearables and smart home devices. Not only are smartphone adoption rates higher among people with disabilities than the general population; they have also been using these devices longer. Dr. Moon challenges us to rethink device-centric" views of technology and instead to think of personal ecosystems of devices where people can easily reach for whatever device is convenient, appropriate, or handy to achieve the task at hand. He also reminds us that while universal design should be a goal, it cannot replace accessibility: and that one person's solution may be another's barrier. https://cassyni-user-files-prod.s3.amazonaws.com/PGFYXtrLLvzCfGCgdmZ8KG https://cassyni.com/slides/outline/Pp67VYX43nt5B4S6ehqoDo https://cassyni.com/events/Pp67VYX43nt5B4S6ehqoDo/abstract https://cassyni-user-files-prod.s3.amazonaws.com/DRvTBxxrbJCARL6oisipJ2 https://cassyni.com/events/Pp67VYX43nt5B4S6ehqoDo?videoPreview=1 Methane, Microbes, and More: Archaea in the Human Microbiomenohttps://cassyni.com/events/Pp67VYX43nt5B4S6ehqoDo?videoPreview=12025-01-21T14:00:00+00:001963.16Microbiome Virtual International ForumArchaea, a distinct domain of life, play critical yet often overlooked roles in the human microbiome. Despite their recognition as members of the human microbiota since the 1970s, archaea remain understudied due to their non-pathogenic nature and technical challenges. In this talk, I will explore the multifaceted contributions of archaea to human health, focusing on their role in fiber digestion, methane production, and interactions with the host. Recent advances from my research have unveiled more than 1,000 archaeal genomes from the human gut, encoding 1.8 million genes, half of which have unknown functions. These findings highlight the untapped potential of archaea in shaping microbiome and human physiology. Through a combination of metagenomics, comparative genomics, and laboratory-based studies such as targeted cultivation, we aim to understand the functional and ecological roles of archaea across diverse human microbiomes, including the gut, respiratory tract, and skin. https://cassyni-user-files-prod.s3.amazonaws.com/DRvTBxxrbJCARL6oisipJ2 https://cassyni.com/events/VFDm14dpspyUJU1tfL5hBB/seminar/qa https://cassyni.com/slides/outline/VFDm14dpspyUJU1tfL5hBB https://cassyni.com/events/VFDm14dpspyUJU1tfL5hBB/abstract https://cassyni-user-files-prod.s3.amazonaws.com/CUQ4VHASBCZAqir5ABgJsG https://cassyni.com/events/VFDm14dpspyUJU1tfL5hBB?videoPreview=1 Static deep stall analysis augmented by numerically constrained turbulent flowsnohttps://cassyni.com/events/VFDm14dpspyUJU1tfL5hBB?videoPreview=12025-01-16T15:00:00+00:002521.24PyFRAs computational resources have advanced, scale-resolving methods like Large Eddy Simulation (LES) have gained popularity in the aerodynamic design particularly in predicting massively separated flow regions. The limitations of traditional Reynolds-Averaged Navier-Stokes (RANS) are evident in this regime, given the importance of the intrinsic unsteadiness and the strong three dimensionality of the flow. This research focuses on wall-resolved Implicit Large Eddy Simulation (ILES) for airfoil flows in deep stall with a focus on its dynamics. Moreover, it is also of interest to understand how the spanwise extent of the computational domain affects the resolved aerodynamic forces and flow dynamics. The simulations in this study analyzed various spanwise extents ($l_z$ ranging from $0.10c$ to $2c$) under specific conditions: a chord Reynolds number $Re = 10^5$, asymptotic Mach number $M_{\infty} = 0.15$, and angle of attack $\alpha = 20$ degrees. Significant differences were found in aerodynamic coefficients and flow dynamics when the smallest spanwise extent was used. Specifically, spectral proper orthogonal decomposition (SPOD) showed that a small span failed to capture critical low-frequency dynamics necessary for predicting adequate stall behavior. Additionally, the turbulence field in the small span case remained largely $\emph{rod-like}$, unlike the three-dimensional turbulence seen in larger spans. The current work propose the nondimensional Spanwise Integral Length Scale ($SILS / l_z$) as a metric for determining the sufficiency of spanwise extent, using two point correlations for the streamwise velocity. Findings suggest that a spanwise extent of $l_z = 1c$ is sufficient, with minimal differences observed between $l_z = 1c$ and $l_z = 2c$. The results emphasize the importance of adequate spanwise resolution to accurately capture deep-stall flow structures and their unsteady behaviour.https://cassyni-user-files-prod.s3.amazonaws.com/CUQ4VHASBCZAqir5ABgJsG https://cassyni.com/slides/outline/RngXgH79od6qGmiL1fhjeM https://cassyni.com/events/RngXgH79od6qGmiL1fhjeM/abstract https://cassyni-user-files-prod.s3.amazonaws.com/UBySnwvqG7jdBj8vuPqaNS https://cassyni.com/events/RngXgH79od6qGmiL1fhjeM?videoPreview=1 Learning the shape: streamlining data needs in 2D irregular contour parameterizationnohttps://cassyni.com/events/RngXgH79od6qGmiL1fhjeM?videoPreview=12024-11-01T19:00:00+00:003621.12AI Institute in Dynamic SystemsThis presentation explores the intersection of machine learning (ML) and scientific discovery, particularly its role in solving complex engineering problems. While ML has proven successful in areas such as drug discovery and atmospheric predictions, its utility is context-dependent and must be justified based on the complexity of the problem and its data requirements. In this work, we present a proof of concept demonstrating the application of ML to optimize heat transfer in microscale geometries, one of the most computationally expensive problems due to the detailed meshing requirements. By applying data-driven approaches, we show how ML can streamline costly computations in thermal analysis without compromising precision. This methodology, developed for microfinned base geometries similar to those used in EV battery pack cooling systems, holds potential for broader applications in optimizing irregular geometries in engineering.https://cassyni-user-files-prod.s3.amazonaws.com/UBySnwvqG7jdBj8vuPqaNS https://cassyni.com/events/53T9jZw7NPqa8nG3jYnPkq/abstract https://cassyni-user-files-prod.s3.amazonaws.com/8DrdGPonjbfevWGuR76BGi https://cassyni.com/events/QJmLergTtcMtzXRcSoxmQ1/seminar/qa https://cassyni.com/slides/outline/QJmLergTtcMtzXRcSoxmQ1 https://cassyni.com/events/QJmLergTtcMtzXRcSoxmQ1/abstract https://cassyni-user-files-prod.s3.amazonaws.com/MYwBuRhPYjVAFr9f49mHae https://cassyni.com/events/QJmLergTtcMtzXRcSoxmQ1?videoPreview=1 SDG 5: How does lived experience impact research focus?nohttps://cassyni.com/events/QJmLergTtcMtzXRcSoxmQ1?videoPreview=12025-02-06T15:00:00+00:003645.04Springer Nature Sustainable Development Goals ProgrammeIntersectionality is a term used to describe the connections between social groups, such as race, gender, class, disability, and sexuality, and the systemic disadvantages felt by each. Discrimination is rife for many communities, and often membership of more than one social minority group can result in compounded and nuanced issues. The intersectionality subgroup is a part of the SDG5 working group, which organises events and campaigns focused on achieving gender equality for all. It can often be difficult to separate gender from other social values, which is what the Intersectionality subgroup hopes to explore. This panel discussion brings together a diverse selection of researchers from varying backgrounds, but all with experience researching social issues. We will discuss and dissect whether their decision to research these topics has been at all influenced by personal experiences of discrimination, and reflect upon how their work has caused their perceptions of themselves and their communities to evolve. Whilst there will not be time to take questions during the session, we invite you to ask questions following the session here on the event webpage, and will endeavour to provide an answer as soon as possible. If your question is aimed at a specific speaker, please do mention their name with your suggestion.https://cassyni-user-files-prod.s3.amazonaws.com/MYwBuRhPYjVAFr9f49mHae https://cassyni.com/slides/outline/Gu3GxbybJk4PEVEhteM8ww https://cassyni.com/events/Gu3GxbybJk4PEVEhteM8ww/abstract https://cassyni-user-files-prod.s3.amazonaws.com/911dDpMRPpjq7AhFLdHGsG https://cassyni.com/events/Gu3GxbybJk4PEVEhteM8ww?videoPreview=1 The methane imperativenohttps://cassyni.com/events/Gu3GxbybJk4PEVEhteM8ww?videoPreview=12024-10-16T14:00:00+00:005718.88Frontiers in ScienceNo abstracthttps://cassyni-user-files-prod.s3.amazonaws.com/911dDpMRPpjq7AhFLdHGsG https://cassyni.com/slides/outline/SHMkqbGZeSaf6EhqomphpZ https://cassyni.com/events/SHMkqbGZeSaf6EhqomphpZ/abstract https://cassyni-user-files-prod.s3.amazonaws.com/8oJbhFCG9bXiDpaAkioUZt https://cassyni.com/events/SHMkqbGZeSaf6EhqomphpZ?videoPreview=1 Disparities Persist, but so do Black Women: Black Women as Economic Contributorsnohttps://cassyni.com/events/SHMkqbGZeSaf6EhqomphpZ?videoPreview=12024-11-20T22:00:00+00:00679.24Center for Black Entrepreneurship, Spelman CollegeNo abstracthttps://cassyni-user-files-prod.s3.amazonaws.com/8oJbhFCG9bXiDpaAkioUZt https://cassyni.com/events/HPiW7v919ZYD3xEDgkU789/seminar/qa https://cassyni.com/slides/outline/HPiW7v919ZYD3xEDgkU789 https://cassyni.com/events/HPiW7v919ZYD3xEDgkU789/abstract https://cassyni-user-files-prod.s3.amazonaws.com/LZcgSteUDdjsth6dfBRhZY https://cassyni.com/events/HPiW7v919ZYD3xEDgkU789?videoPreview=1 How can Nonlinear Dynamics complement Machine Learning?nohttps://cassyni.com/events/HPiW7v919ZYD3xEDgkU789?videoPreview=12025-03-18T14:00:00+00:002676.8Nonlinear Dynamics, an International Journal of Nonlinear Dynamics and Chaos in Engineering SystemsMachine learning is rapidly evolving and is increasingly being used for developing dynamic models and for analysis and diagnostics. However, these data-based models are often not robust and generalizable. On the other hand, nonlinear dynamics is able to satisfactorily explain many complex phenomena we observe in the physical world. We will explore how these physics-derived insights can help improve data-based models and especially assist diagnostics. Engineering and biomedical applications will be provided to discuss the promising synthesis of nonlinear dynamics and machine learning. ### Who Should Attend: Engineers and scientists who are curious to explore how nonlinear dynamics can contribute to machine learning. ### Key Take-away point: Nonlinear dynamics, which provides the most comprehensive description of dynamical system behavior, can enrich the rapidly evolving field of machine learning. https://cassyni-user-files-prod.s3.amazonaws.com/LZcgSteUDdjsth6dfBRhZY https://cassyni.com/events/TGgb3b5VvicXuUEFCKEUG5/seminar/qa https://cassyni.com/slides/outline/TGgb3b5VvicXuUEFCKEUG5 https://cassyni.com/events/TGgb3b5VvicXuUEFCKEUG5/abstract https://cassyni-user-files-prod.s3.amazonaws.com/KJoYR2tahq6Xdz2t94791Y https://cassyni.com/events/TGgb3b5VvicXuUEFCKEUG5?videoPreview=1 Identification, Prevalence, Experience, and Treatment of Neurological Conditions in Womennohttps://cassyni.com/events/TGgb3b5VvicXuUEFCKEUG5?videoPreview=12025-06-18T14:00:00+00:003439.0Women's HealthWomen face a higher risk of many debilitating neurological conditions including, but not limited to Alzheimer’s disease, multiple sclerosis, migraines, myasthenia gravis, Parkinson’s disease, stroke, and vascular dementia. Not only are these conditions more prevalent in women than men, but women face noteworthy differences in the risk factors, symptoms, disease progression, and experience of many neurological diseases. Since women have traditionally been underrepresented in both randomized controlled trails and neurological research, much less is known about the unique risk factors, symptomology, treatment efficacy, and healthcare costs of neurological conditions in women. This special collection aims to gather and disseminate innovative quantitative and qualitative research, critical reviews, policy analyses, and case studies exploring the identification, prevalence, treatment, cost, and experience of neurological conditions in women. By showcasing the unique symptoms, treatments, experiences, challenges, and circumstances of women with neurological conditions, this collection will contribute to a deeper awareness and understanding of these conditions while promoting strategies to improve the diagnosis, treatment, and care of women suffering from these conditions.https://cassyni-user-files-prod.s3.amazonaws.com/KJoYR2tahq6Xdz2t94791Y https://cassyni.com/events/34uyn6NnRHUdjnUQGXwAqj/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Cw5RfeW5saCQoa5xpaynBQ https://cassyni.com/events/DSXfkSxodu74GHmYHdt4XF/abstract https://cassyni-user-files-prod.s3.amazonaws.com/WqM5uFCdE8gr6Y1gXtCRSn https://cassyni.com/events/9yzSRfS8ZhEREbTydyW6zR/seminar/qa https://cassyni.com/slides/outline/9yzSRfS8ZhEREbTydyW6zR https://cassyni.com/events/9yzSRfS8ZhEREbTydyW6zR/abstract https://cassyni-user-files-prod.s3.amazonaws.com/XfCKffq3ibskK3oz2HW25k https://cassyni.com/events/9yzSRfS8ZhEREbTydyW6zR?videoPreview=1 Status of LES of Wall-Bounded Flows in Industrial CFDnohttps://cassyni.com/events/9yzSRfS8ZhEREbTydyW6zR?videoPreview=12025-05-08T12:00:00+00:003341.44Sci-Fi-TurboWith the advent of GPU power, LES of wall-bounded flows becomes feasible in industrial CFD simulations with turn-around times within engineering expectations. The presentation will provide a broad-brush overview of the different elements in meshing, numerics and modeling used in such simulations. Several examples of simple building-block test cases to complex semi-realistic applications will be presented. Challenges and next steps and will be discussed. https://cassyni-user-files-prod.s3.amazonaws.com/XfCKffq3ibskK3oz2HW25k https://cassyni.com/events/PKXNnkRBpR77GHTy5masHo/abstract https://cassyni-user-files-prod.s3.amazonaws.com/6N794Gq1Lhp8h9Tw62BxMU https://cassyni.com/slides/outline/62qEApmpTPizbQhhXRrW29 https://cassyni.com/events/62qEApmpTPizbQhhXRrW29/abstract https://cassyni-user-files-prod.s3.amazonaws.com/HBwHbq7fYHP3fZ5zzTCayL https://cassyni.com/events/62qEApmpTPizbQhhXRrW29?videoPreview=1 Direct mapping of nonreciprocal discrete models using simple acoustic networksnohttps://cassyni.com/events/62qEApmpTPizbQhhXRrW29?videoPreview=12025-06-17T13:00:00+00:003759.04MetaMATA plethora of works in classical wave systems is dedicated to mimicking phenomena inspired by discrete models, typically originating from condensed matter physics. The most common approach is to “discretize” a continuous medium in order to reproduce the behavior of a given discrete model. This is usually achieved by introducing resonators and arranging them in periodic configurations that satisfy certain geometrical symmetries. Here, we present an alternative, broadband, and resonator-free method for discretizing space using networks of waveguides. This approach enables the construction of very simple configurations that can directly emulate a wide range of discrete models, capturing not only their edge or skin modes but their entire spectrum—while preserving their symmetries. As an example, I will discuss the theoretical and experimental realization of the Hatano-Nelson model in acoustic waveguides, using two different resonator-free configurations. https://cassyni-user-files-prod.s3.amazonaws.com/HBwHbq7fYHP3fZ5zzTCayL https://cassyni.com/events/UkEgapofc3JesSn7m92Xpy/abstract https://cassyni-user-files-prod.s3.amazonaws.com/9Chj5GHAJqZ99JqNq9UXQz https://cassyni.com/events/TkwUVTWcj8CWCgx7fAZD25/seminar/qa https://cassyni.com/slides/outline/TkwUVTWcj8CWCgx7fAZD25 https://cassyni.com/events/TkwUVTWcj8CWCgx7fAZD25/abstract https://cassyni-user-files-prod.s3.amazonaws.com/ME1z6Jw6CVytLhcV2MYLMt https://cassyni.com/events/TkwUVTWcj8CWCgx7fAZD25?videoPreview=1 Global perspectives on human milk and infant microbiomesnohttps://cassyni.com/events/TkwUVTWcj8CWCgx7fAZD25?videoPreview=12025-09-11T01:30:00+00:00888.52Microbiome Virtual International ForumBreastfeeding is a key driver of infant microbiome development. Human milk composition, including its microbiome, varies across cultures and geographies according to local environments and lifestyle practices. These variations in human milk are fundamental to shaping and understanding variations in infant microbiome development and associated health outcomes globally.https://cassyni-user-files-prod.s3.amazonaws.com/ME1z6Jw6CVytLhcV2MYLMt https://cassyni.com/slides/outline/6X4VW4h3rSPC4vxwncM4sF https://cassyni.com/events/6X4VW4h3rSPC4vxwncM4sF/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Djm6TKoGtW6NDxqisGrVCS https://cassyni.com/events/6X4VW4h3rSPC4vxwncM4sF?videoPreview=1 Identifying Impactful Research Topicsnohttps://cassyni.com/events/6X4VW4h3rSPC4vxwncM4sF?videoPreview=12023-05-04T14:00:00+00:005788.84No abstracthttps://cassyni-user-files-prod.s3.amazonaws.com/Djm6TKoGtW6NDxqisGrVCS https://cassyni.com/events/PonGEcrJcph5ZWBqYcuc3o/seminar/qa https://cassyni.com/slides/outline/PonGEcrJcph5ZWBqYcuc3o https://cassyni.com/events/PonGEcrJcph5ZWBqYcuc3o/abstract https://cassyni-user-files-prod.s3.amazonaws.com/FpbCwPGuJwUvuHVj7s8Zjc https://cassyni.com/events/PonGEcrJcph5ZWBqYcuc3o?videoPreview=1 An integrated airborne transmission risk assessment model for respiratory viruses: short- and long-range contributionsnohttps://cassyni.com/events/PonGEcrJcph5ZWBqYcuc3o?videoPreview=12025-07-15T10:00:00+00:004735.04Royal Society PublishingThis study presents an advanced airborne transmission risk assessment model that integrates both short- and long-range routes in the spread of respiratory viruses, building upon the CERN Airborne Model for Indoor Risk Assessment (CAiMIRA) and aligned with the new World Health Organization (WHO) terminology. Thanks to a two-stage exhaled jet approach, the model accurately simulates short-range exposures, thereby improving infection risk predictions across diverse indoor settings. Key findings reveal that in patient wards, the short-range viral dose is 10-fold higher than the long-range component, highlighting the critical role of close proximity interactions. Implementation of FFP2 respirators resulted in a remarkable 13-fold reduction in viral dose, underscoring the effectiveness of personal protective equipment (PPE). Additionally, the model demonstrated that an 8 h exposure in a poorly ventilated office can equate to the risk of a 15 min face-to-face, mask-less interaction, emphasizing the importance of physical distancing and source control. We also found in high-risk or low-occupancy settings, that secondary transmission is driven more by overall epidemic trends than by the presence of individual superspreaders. Monte Carlo simulations across various scenarios, including classrooms and offices, validate the model’s robustness in optimizing infection prevention strategies. These findings support targeted interventions for short- and long-range exposure to reduce airborne transmission.https://cassyni-user-files-prod.s3.amazonaws.com/FpbCwPGuJwUvuHVj7s8Zjc https://cassyni.com/slides/outline/7WPKi4Vz8iR4tAVMB9kqJm https://cassyni.com/events/7WPKi4Vz8iR4tAVMB9kqJm/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Seytv3xYcNX1wEAYi223FL https://cassyni.com/events/7WPKi4Vz8iR4tAVMB9kqJm?videoPreview=1 Cataloging the global microbiome. Very big data for very small thingsnohttps://cassyni.com/events/7WPKi4Vz8iR4tAVMB9kqJm?videoPreview=12025-09-09T15:15:00+00:00613.36Microbiome Virtual International ForumThe global microbiome is the collection of all microbes living on planet Earth. To study this system, we have developed approaches and methods to catalog this habitat, resulting in the Global Microbial Gene Catalog, version 1 (GMGCv1) and SPIRE, a collection of metagenome-assembled genomes (MAGs). Recently, we have expanded this work to also include small open reading frames (we currently consider all open reading frames ≥10 amino acids). We first built a catalogue of smorfs, which contains almost 1 billion sequences. https://cassyni-user-files-prod.s3.amazonaws.com/Seytv3xYcNX1wEAYi223FL https://cassyni.com/events/Ev7PQKCriaiuNk1p92cZim/seminar/qa https://cassyni.com/slides/outline/Ev7PQKCriaiuNk1p92cZim https://cassyni.com/events/Ev7PQKCriaiuNk1p92cZim/abstract https://cassyni-user-files-prod.s3.amazonaws.com/CLsxuFxhY1cNhB8Pdei6te https://cassyni.com/events/Ev7PQKCriaiuNk1p92cZim?videoPreview=1 Curvature dynamics of biomembranes: role of membrane viscosity and interleaflet frictionnohttps://cassyni.com/events/Ev7PQKCriaiuNk1p92cZim?videoPreview=12025-07-17T14:00:00+00:003957.84Journal of Biological PhysicsLipid bilayers are the main structural component of the membranes that shape and compartmentalize cells. Cell architecture is highly dynamic and membranes' conformation changes dramatically in processes such as movement, division, and vesicle trafficking. Fluidity plays essential role in the structural malleability and diversity of static shapes of membranes. However, its importance in the dynamics of membrane deformations is less appreciated. Membrane bending by thermal or active forces is commonly assumed to be damped by viscous losses in the surrounding medium. In this talk, I will present our experimental and theoretical work where we demonstrated that dissipation within the membrane controls the undulation dynamics of nonplanar membranes with a radius of curvature smaller than the Saffman-Delbruck length. Using flickering spectroscopy of giant vesicles made of DPPC:Cholesterol and pure diblock-copolymer bilayer membranes, the signature of membrane dissipation was detected in curvature fluctuations [1]. We extend the theoretical analysis to submicron liposomes, where lipid density fluctuations, which arise from the stretching and compression of the monolayer leaflets, and intermonolayer friction become important. The results highlight the crucial role of intramembrane dissipation in cellular membrane remodeling and in the thermally driven curvature fluctuations of submicron liposomes.https://cassyni-user-files-prod.s3.amazonaws.com/CLsxuFxhY1cNhB8Pdei6te https://cassyni.com/events/GtjRhgJqsmsPcvzSnZQwmw/seminar/qa https://cassyni.com/slides/outline/GtjRhgJqsmsPcvzSnZQwmw https://cassyni.com/events/GtjRhgJqsmsPcvzSnZQwmw/abstract https://cassyni-user-files-prod.s3.amazonaws.com/DeybohXK5PCqaq4BhFxPze https://cassyni.com/events/GtjRhgJqsmsPcvzSnZQwmw?videoPreview=1 Visual Clarity and Expressiveness in Logic Diagramsnohttps://cassyni.com/events/GtjRhgJqsmsPcvzSnZQwmw?videoPreview=12025-07-16T14:00:00+00:005001.44Logica UniversalisLogic diagrams help people understand and solve problems in logic. This paper explores how different types of these diagrams try to find a good balance between showing complex ideas fully (expressiveness) and being easy to understand visually (clarity). It traces their journey from early, straightforward drawings to more complex systems with clear rules to prevent confusion. This change often involved making a strategic choice, a calculated “chance,” to move away from very direct visual representation to gain greater overall clarity and power in problem-solving. This tension between comprehensive representation and ease of interpretation is a central challenge for anyone designing diagrammatic systems for logical relationships. A diagram that is too simple cannot convey intricate ideas completely, but one that tries to show every detail might become too complicated to understand. This means that different diagram types are often best suited for specific logical tasks or levels of complexity.https://cassyni-user-files-prod.s3.amazonaws.com/DeybohXK5PCqaq4BhFxPze https://cassyni.com/events/4YXKYb8iuL2FfwBJKbVqx9/seminar/qa https://cassyni.com/slides/outline/4YXKYb8iuL2FfwBJKbVqx9 https://cassyni.com/events/4YXKYb8iuL2FfwBJKbVqx9/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Bgc2SuCcL1VcRghiPLANmU https://cassyni.com/events/4YXKYb8iuL2FfwBJKbVqx9?videoPreview=1 Patient-related Outcome Measures and Quality of Life in Dialysis 1330-1500nohttps://cassyni.com/events/4YXKYb8iuL2FfwBJKbVqx9?videoPreview=12025-09-19T12:30:00+00:005618.52Imperial College Renal and Transplant Centre1330 Frailty 1400 Physiotherapy in Dialysis 1430 Incremental Dialysis Image credit: [Austin Distel (Unsplash)](https://unsplash.com/photos/person-reading-book-during-daytime-Ej_GTF0JPss).https://cassyni-user-files-prod.s3.amazonaws.com/Bgc2SuCcL1VcRghiPLANmU https://cassyni.com/slides/outline/KNHJC2DDW2psbRiGSLFmfs https://cassyni.com/events/KNHJC2DDW2psbRiGSLFmfs/abstract https://cassyni-user-files-prod.s3.amazonaws.com/SKAm5Tz5j7sjVWxWP66ver https://cassyni.com/events/KNHJC2DDW2psbRiGSLFmfs?videoPreview=1 The flexoskeleton: regulation of stomatal dynamics by guard cell wallsnohttps://cassyni.com/events/KNHJC2DDW2psbRiGSLFmfs?videoPreview=12024-10-22T13:00:00+00:001868.64The New Phytologist FoundationStomatal guard cells are encased in strong, flexible cell walls that underpin their dynamic responses to signaling cues, but how these walls are assembled with these properties is incompletely understood. Here, we explored how the properties of guard cell walls change during stomatal maturation in Arabidopsis thaliana and result in stomatal complexes that open and close efficiently. We established milestones for stomatal maturation, when the stomatal pore and guard cells enlarge with distinct kinetics, and found that although guard cell walls thicken during maturation, they become more mechanically anisotropic and achieve stomatal opening with smaller changes in turgor pressure and less energy input. We also found that cellulose is required for normal stomatal maturation and that both cellulose and pectins are critical for mechanical anisotropy and efficient stomatal opening in mature guard cells. Based on their molecular architectures, we developed a multi-scale model that recapitulates the biomechanics of wild type and mutant guard cell walls. Finally, we used cell ablation and automated cell segmentation in both Arabidopsis and grass stomatal complexes to find that cells adjacent to guard cells constrain their motions in unexpected ways. Together, these data functionally connect the molecular composition and structure of guard cell walls to their biomechanical properties and the efficiency of stomatal dynamics.https://cassyni-user-files-prod.s3.amazonaws.com/SKAm5Tz5j7sjVWxWP66ver https://cassyni.com/slides/outline/Sn1MtGv65u8i61EjQD7W5s https://cassyni.com/events/Sn1MtGv65u8i61EjQD7W5s/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Sx3ptaXqHX16aB6WQrDsVp https://cassyni.com/events/Sn1MtGv65u8i61EjQD7W5s?videoPreview=1 Harnessing structural instabilities within metamaterials to enhance energy absorption systemsnohttps://cassyni.com/events/Sn1MtGv65u8i61EjQD7W5s?videoPreview=12024-12-04T14:00:00+00:003242.48Department of Aeronautics and AstronauticsAdvances in additive manufacturing are increasingly allowing bespoke, carefully designed, metamaterial lattice structures to be constructed for enhanced mechanical performance. For instance, in structural elements that are designed to absorb energy and shield a more valuable structure, the properties combining a high initial stiffness followed by a quasi-zero underlying stiffness, ensure that a desired energy quantity may be absorbed within a limited displacement and that any stress transfer to the valuable structure is minimised. Presently, a lattice structure is studied analytically, numerically and in some prototype experiments, which is deliberately designed to switch locally under compression from conventional material behaviour to exhibiting auxetic (negative Poisson's ratio) behaviour through a sequence of snap-through instabilities within layers of individual lattice cells. The sequence of buckling instabilities can potentially be controlled to maintain the loading level alongside the quasi-zero structural stiffness while the required energy quantity is absorbed, without necessarily damaging the material permanently in the process. This is a departure from the usual paradigm where such structures are presently designed to be sacrificial and opens up the possibility of introducing such structural elements that are repairable and therefore reusable, which may be advantageous in certain applications.https://cassyni-user-files-prod.s3.amazonaws.com/Sx3ptaXqHX16aB6WQrDsVp https://cassyni.com/slides/outline/FR6TpZ31zNPiomFb3Dfj4y https://cassyni.com/events/FR6TpZ31zNPiomFb3Dfj4y/abstract https://cassyni-user-files-prod.s3.amazonaws.com/3KMfCUnaNgVL9wAaxCVijg https://cassyni.com/events/FR6TpZ31zNPiomFb3Dfj4y?videoPreview=1 The Molecular Twin artificial-intelligence platform integrates multi-omic data to predict outcomes for pancreatic adenocarcinoma patientsnohttps://cassyni.com/events/FR6TpZ31zNPiomFb3Dfj4y?videoPreview=12025-04-03T18:00:00+00:003552.36Center for Cancer TrainingContemporary analyses focused on a limited number of clinical and molecular biomarkers have been unable to accurately predict clinical outcomes in pancreatic ductal adenocarcinoma. Here we describe a precision medicine platform known as the Molecular Twin consisting of advanced machine-learning models and use it to analyze a dataset of 6,363 clinical and multi-omic molecular features from patients with resected pancreatic ductal adenocarcinoma to accurately predict disease survival (DS). We show that a full multi-omic model predicts DS with the highest accuracy and that plasma protein is the top single-omic predictor of DS. A parsimonious model learning only 589 multi-omic features demonstrated similar predictive performance as the full multi-omic model. Our platform enables discovery of parsimonious biomarker panels and performance assessment of outcome prediction models learning from resource-intensive panels. This approach has considerable potential to impact clinical care and democratize precision cancer medicine worldwide.https://cassyni-user-files-prod.s3.amazonaws.com/3KMfCUnaNgVL9wAaxCVijg https://cassyni.com/slides/outline/VjvcH1K881P4wdU2f72qGH https://cassyni.com/events/VjvcH1K881P4wdU2f72qGH/abstract https://cassyni-user-files-prod.s3.amazonaws.com/VxmBXCSPSrVCmh7CSnenQW https://cassyni.com/events/VjvcH1K881P4wdU2f72qGH?videoPreview=1 How to Develop Near-Exact Distributions for Likelihood Ratio Statistics used to Test Different Covariance Structuresnohttps://cassyni.com/events/VjvcH1K881P4wdU2f72qGH?videoPreview=12025-02-04T14:00:00+00:003218.8Research Seminars by Springer NatureThe analysis of the covariance structure is a crucial topic in multivariate statistics. Not only does the covariance matrix contain valuable information about the dependence structure between variables, enabling informed conclusions and optimal decision-making, but it also helps in calibrating statistical models. With the increasing use of more complex models, it has become essential to verify assumptions about the structure of covariance matrices. In this study, we review several significant covariance structures and demonstrate how it is possible to simultaneously test the presence of different structures in the diagonal blocks of a covariance matrix. We examine the distribution of the likelihood ratio test statistic and derive the expression for its h-th null moment. To ensure practical usability, we develop near-exact approximations for the likelihood ratio statistic. We provide a practical application using real data, along with numerical studies and simulations, to illustrate the applicability of the test and assess the precision of the developed near-exact approximations. Finally, we demonstrate how the proposed methodology can be extended to the study of more complex covariance structures.https://cassyni-user-files-prod.s3.amazonaws.com/VxmBXCSPSrVCmh7CSnenQW https://cassyni.com/slides/outline/2aGNjQjFypvak1wWg6eNaR https://cassyni.com/events/2aGNjQjFypvak1wWg6eNaR/abstract https://cassyni-user-files-prod.s3.amazonaws.com/GTjCXdDeSmEUUimJji4NrA https://cassyni.com/events/2aGNjQjFypvak1wWg6eNaR?videoPreview=1 Half-Closed Discontinuous Galerkin Discretisationsnohttps://cassyni.com/events/2aGNjQjFypvak1wWg6eNaR?videoPreview=12024-12-06T17:00:00+00:001759.48JKW Symposium TeamWe introduce the concept of half-closed nodes for nodal Discontinuous Galerkin (DG) discretisations. This is in contrast to more commonly used closed nodes in DG where in each element nodes are placed on every boundary. Half-closed nodes relax this constraint by only requiring nodes on a subset of the boundaries in each element, with this extra freedom in node placement allowing for increased efficiency in the assembly of DG operators. To determine which element boundaries half-closed nodes are placed on we outline a simple procedure based on switch functions. We examine the effect on operator sparsity from using the different types of nodes and show that in particular for the Laplace operator for there to be no difference in the sparsity from using half-closed or closed nodes. We also discuss in this work some linear solver techniques commonly used for Finite Element or Discontinuous Galerkin methods such as static condensation and block-based methods, and how they can be applied to half-closed DG discretisations. Finally we demonstrate its use on a range of test problems including in CFD, and benchmark its performance on these numerical examples.https://cassyni-user-files-prod.s3.amazonaws.com/GTjCXdDeSmEUUimJji4NrA https://cassyni.com/events/LrHMZLBZd8LcuLzQY5gEZs/abstract https://cassyni-user-files-prod.s3.amazonaws.com/FhAKBMpT7xbNki8JPacq4i https://cassyni.com/slides/outline/8W5FQF1SegVUxMBG57m8k5 https://cassyni.com/events/8W5FQF1SegVUxMBG57m8k5/abstract https://cassyni-user-files-prod.s3.amazonaws.com/KU1sbNUUg63MaWfyuGj5gz https://cassyni.com/events/8W5FQF1SegVUxMBG57m8k5?videoPreview=1 Breakdown and repair of metabolism in the aging brainnohttps://cassyni.com/events/8W5FQF1SegVUxMBG57m8k5?videoPreview=12025-05-07T14:00:00+00:005514.2Frontiers in Science### Modeling metabolism in the aging brain A new open-source model of brain metabolism – the most complex ever built – shows how altering key chemicals through diet and exercise could restore resilience to aged brain cells. The model, published in a *[Frontiers in Science](https://www.frontiersin.org/journals/science/articles/10.3389/fsci.2025.1441297/full)* lead article, also reveals new targets for future dementia treatments. Join the model’s creators and study authors for an in-depth discussion on the most comprehensive computer model of brain metabolism to date. Building on these findings, this Deep Dive reveals how the new model, available open-source to researchers via the [Open Brain Platform](https://www.openbraininstitute.org/resources), could accelerate research into interventions to protect and repair the aging brain, such as diet, exercise, and new drug targets. Join us to learn how aging affects metabolism, neuronal activity, and blood flow in the brain, intricately mapped across 16,800 biochemical interactions. You’ll also have the chance to pose questions during the audience Q&A [Register here](https://events.frontiersin.org/aging-brain/Cassyni)https://cassyni-user-files-prod.s3.amazonaws.com/KU1sbNUUg63MaWfyuGj5gz https://cassyni.com/events/Qo8iZFB8JTf3vyWRYYPeN9/seminar/qa https://cassyni.com/slides/outline/Qo8iZFB8JTf3vyWRYYPeN9 https://cassyni.com/events/Qo8iZFB8JTf3vyWRYYPeN9/abstract https://cassyni-user-files-prod.s3.amazonaws.com/AYTy64zF8SjF6gGQuowVMQ https://cassyni.com/events/Qo8iZFB8JTf3vyWRYYPeN9?videoPreview=1 Alternatives in Animal Research: The Zebrafish Optionnohttps://cassyni.com/events/Qo8iZFB8JTf3vyWRYYPeN9?videoPreview=12025-09-24T11:00:00+00:004218.04The Pharmacological Research family of journalsThe utilisation of animals in scientific research has been a longstanding subject of debate, with concerns about animal welfare and ethics. In response, researchers have been investigating alternative models that can reduce the need for animal testing. One such alternative is the zebrafish (Danio rerio), a diminutive freshwater fish that has garnered popularity as a model organism across various fields of investigation. Zebrafish present several advantages as substitutes for traditional animal models. They possess genetic similarities to humans, with numerous genes exhibiting functions that are comparable. Their rapid development and high fecundity render them suitable for high-throughput screening and genetic research. Moreover, zebrafish are relatively cost-effective to maintain and breed, thereby reducing the expenses associated with animal research. A significant benefit of zebrafish is their transparency. Zebrafish embryos are transparent, allowing researchers to observe developmental processes in real-time. This transparency, coupled with advances in imaging technologies, has enabled detailed examination of tissue and organ development at an unprecedented level. Zebrafish have been employed to model a broad spectrum of human diseases, including cancer, neurodegenerative disorders, and infectious diseases. By introducing specific mutations or genetic modifications, researchers can develop zebrafish models that simulate human disease conditions. These models serve to elucidate disease mechanisms, evaluate potential therapies, and identify novel targets for treatment. The application of zebrafish in research holds potential to reduce animal testing in several ways. Firstly, they can serve as preliminary screening tools to identify prospective toxic compounds or therapeutic agents. Secondly, zebrafish facilitate the study of disease mechanisms and the discovery of novel therapeutic targets, thereby decreasing reliance on animal testing in the development of new treatments. Lastly, zebrafish are instrumental in assessing the efficacy and safety of emerging therapies, providing valuable insights into their potential effectiveness in humans. In conclusion, zebrafish represent a promising alternative to conventional animal models in scientific inquiry. Their genetic kinship to humans, rapid development, and high fecundity render them an attractive system for exploring various biological processes. With their transparency and suitability for high-throughput screening, zebrafish are poised to play an increasingly vital role in advancing our comprehension of human biology and disease. Adoption of zebrafish as an alternative model supports the principles of the 3Rs (replacement, reduction, and refinement) and ultimately contributes to the enhancement of human health. https://cassyni-user-files-prod.s3.amazonaws.com/AYTy64zF8SjF6gGQuowVMQ https://cassyni.com/slides/outline/34c8XAi2zKHe8EE9ASzyfj https://cassyni.com/events/34c8XAi2zKHe8EE9ASzyfj/abstract https://cassyni-user-files-prod.s3.amazonaws.com/BhhektDbvgPpG6twNRqBmY https://cassyni.com/events/34c8XAi2zKHe8EE9ASzyfj?videoPreview=1 Accessible Microbiota Drug Development: First Head-to-Head Trial of Defined LBP vs. FMTnohttps://cassyni.com/events/34c8XAi2zKHe8EE9ASzyfj?videoPreview=12025-11-12T15:00:00+00:00852.8Microbiome Virtual International ForumFecal microbiota transplantation (FMT) is an effective therapy for recurrent Clostridioides difficile infection (rCDI) but has undefined composition and poor scalability. In vitro manufactured live biotherapeutic products (LBP) enable both scalability and defined strain composition but with higher manufacturing complexity, resulting in few LBP trials. We developed an accessible platform to produce human-grade LBPs. We provide regulatory documentation and manufacturing protocols to facilitate translating microbiome advances to human trials. With this platform, we conduct the first direct comparison of the same bacterial strains administered after in vitro manufacturing (LBP) compared to donor sourced (FMT) across two doses. In a phase 1b randomized trial (n=18, NCT05911997), an endoscopic dose of the 15-strain consortium MTC01 was safe with rCDI prevention eight weeks after dosing in seven out of nine LBP patients, similar to eight out of nine FMT patients. Notably, MTC01 strain engraftment was superior to FMT at higher doses.https://cassyni-user-files-prod.s3.amazonaws.com/BhhektDbvgPpG6twNRqBmY https://cassyni.com/events/DuitrPpF8bVQxwMQCCfMUH/seminar/qa https://cassyni.com/slides/outline/DuitrPpF8bVQxwMQCCfMUH https://cassyni.com/events/DuitrPpF8bVQxwMQCCfMUH/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Fo4KyUjodbHotWB1csgVok https://cassyni.com/events/DuitrPpF8bVQxwMQCCfMUH?videoPreview=1 RAMP Community Call #2nohttps://cassyni.com/events/DuitrPpF8bVQxwMQCCfMUH?videoPreview=12025-08-26T19:00:00+00:001962.72Research Evaluation and Analytics Capacity HubLearn more about the Research Analytics Mentorship Program (RAMP), a signature program of the REACH Network. This peer-to-peer mentorship program aims to work with participants to grow and expand knowledge within areas related to research analytics, responsible evaluation, data-driven decision making and use of data within the field of research management. This community call will introduce participants to the RAMP program and answer any questions you might have. This is the second of two identical informational sessions about this program. https://cassyni-user-files-prod.s3.amazonaws.com/Fo4KyUjodbHotWB1csgVok https://cassyni.com/events/8yErPZLzk1xPZqe4BixMk9/seminar/qa https://cassyni.com/slides/outline/8yErPZLzk1xPZqe4BixMk9 https://cassyni.com/events/8yErPZLzk1xPZqe4BixMk9/abstract https://cassyni-user-files-prod.s3.amazonaws.com/HjgHcWYpBSd9Tpg8BxBQi https://cassyni.com/events/8yErPZLzk1xPZqe4BixMk9?videoPreview=1 Multiscale modelling based on biophysical mechanisms for the human digital twinnohttps://cassyni.com/events/8yErPZLzk1xPZqe4BixMk9?videoPreview=12025-12-09T23:00:00+00:004043.96Auckland Bioengineering InstituteWe have developed a biophysical modelling framework in the 12 Labours project, using compartmental bond graphs and spatial scaffolds. Bond graphs allow us to represent the physiological function of proteins and functional cell units based on conservation of mass, charge and energy. Cell models of epithelial cells, cardiomyocytes, and other cell types, are used to understand how cells maintain homeostasis. To understand homeostasis at the whole-body level, the cell models are being incorporated into models of the cardiorespiratory system and the autonomic nervous system. Spatial finite element scaffolds are used to represent organ/tissue structure and whole-body anatomy. The talk will show how this physics-based multiscale modelling framework is being developed to help interpret physiological and anatomical data for the human digital twin. https://cassyni-user-files-prod.s3.amazonaws.com/HjgHcWYpBSd9Tpg8BxBQi https://cassyni.com/slides/outline/5WksJ2r6UXvnkRT8q834BF https://cassyni.com/events/5WksJ2r6UXvnkRT8q834BF/abstract https://cassyni-user-files-prod.s3.amazonaws.com/8jyZ2ueEPTGHyC7F2jNqNN https://cassyni.com/events/5WksJ2r6UXvnkRT8q834BF?videoPreview=1 How Has the Pandemic Influenced Public Attitudes Toward Science?nohttps://cassyni.com/events/5WksJ2r6UXvnkRT8q834BF?videoPreview=12021-02-23T06:00:00+00:003586.0Part of the nonprofit Annual Reviews organizationCovid-19 has thrust science into the public consciousness. In the past year, the study of public health, mRNA technology, developmental psychology, immunology, behavior, and many others besides, have enjoyed a previously unimaginable level of attention. What effect is this having on how science and scientists are viewed by the public? In the United States, a growing number of people say that they will get vaccinated against Covid-19, but a sizable minority will not. And, while 85 percent of adults have confidence in scientists to act in the best interests of the public, only 39 percent have “a great deal of confidence” in this. We may have reached a pivotal moment in the relationship between science and the public. This discussion will explore attitudes to science, how they have changed in the past year, and the role that group identities play in shaping people’s views. It will also consider the lessons that science should learn from these responses, as well as from the pandemic.https://cassyni-user-files-prod.s3.amazonaws.com/8jyZ2ueEPTGHyC7F2jNqNN https://cassyni.com/slides/outline/4XTfCfZ3bcpe5fd8j9ZjNM https://cassyni.com/events/4XTfCfZ3bcpe5fd8j9ZjNM/abstract https://cassyni-user-files-prod.s3.amazonaws.com/PM7i8QL2LSHTA6sRdZ984v https://cassyni.com/events/4XTfCfZ3bcpe5fd8j9ZjNM?videoPreview=1 Women in Fluids Discussion Panelnohttps://cassyni.com/events/4XTfCfZ3bcpe5fd8j9ZjNM?videoPreview=12024-01-26T06:00:00+00:002813.88Leeds Institute for Fluid DynamicsNo abstracthttps://cassyni-user-files-prod.s3.amazonaws.com/PM7i8QL2LSHTA6sRdZ984v https://cassyni.com/slides/outline/3ZbCwQYCG6xTZFTv4e491w https://cassyni.com/events/3ZbCwQYCG6xTZFTv4e491w/abstract https://cassyni-user-files-prod.s3.amazonaws.com/UWu48ipbxgyL91fTANu8Tp https://cassyni.com/events/3ZbCwQYCG6xTZFTv4e491w?videoPreview=1 A New Urgency in Scholarly Communicationsnohttps://cassyni.com/events/3ZbCwQYCG6xTZFTv4e491w?videoPreview=12025-01-15T14:00:00+00:001789.6Academic Publishing in EuropeNo abstracthttps://cassyni-user-files-prod.s3.amazonaws.com/UWu48ipbxgyL91fTANu8Tp https://cassyni.com/slides/outline/HsyPZna7wy8BMAx69bnqt9 https://cassyni.com/events/HsyPZna7wy8BMAx69bnqt9/abstract https://cassyni-user-files-prod.s3.amazonaws.com/V8sKBphCpeYFhx5TajDBRg https://cassyni.com/events/HsyPZna7wy8BMAx69bnqt9?videoPreview=1 Panel Discussion: Navigating the Transition from Academia to Industrynohttps://cassyni.com/events/HsyPZna7wy8BMAx69bnqt9?videoPreview=12025-04-18T12:00:00+00:003595.2Thieme India ChemTalksNo abstracthttps://cassyni-user-files-prod.s3.amazonaws.com/V8sKBphCpeYFhx5TajDBRg https://cassyni.com/events/aaT3EDoTrrAfqFbn8e597/seminar/qa https://cassyni.com/slides/outline/aaT3EDoTrrAfqFbn8e597 https://cassyni.com/events/aaT3EDoTrrAfqFbn8e597/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Sj9kMjPFNpVKm2aZYgGZeN https://cassyni.com/events/aaT3EDoTrrAfqFbn8e597?videoPreview=1 Investigating source use in L2 student writing: vocabulary, development and stakeholder perceptions (work-in-progress)nohttps://cassyni.com/events/aaT3EDoTrrAfqFbn8e597?videoPreview=12025-06-06T01:10:00+00:003002.24Linguistics and Applied Language StudiesStudent plagiarism is a topic of considerable concern in higher education. Developing academic writers often face accusations of plagiarism, despite their best intention to produce work that meets the expectations of their new literacy community. For L2 students, source-based writing may be particularly challenging due to having to read more complex texts and to write in an academic style. Students have been found to resort to a coping strategy called patchwriting to deal with such difficulties. Despite the view of patchwriting as a form of plagiarism in university policies, it is increasingly recognised as a developmental stage, rather than a deceptive writing strategy. The proposed study focuses on this phenomenon by exploring a potential relationship with writers' vocabulary knowledge, as well as their developmental trajectories. In this presentation, I will talk about the motivation and rationale behind my doctoral research. I will also discuss my proposed methodology to address the research questions. Due to the pre-data collection stage of the research, no findings are available yet, but I will welcome any questions, feedback or observations that I can take forward to refine my research approach.https://cassyni-user-files-prod.s3.amazonaws.com/Sj9kMjPFNpVKm2aZYgGZeN https://cassyni.com/events/8zJWjUvg3jA1AQn4k1VoZ7/abstract https://cassyni-user-files-prod.s3.amazonaws.com/CCrKmoHPQCiPf6UNRWXtKY https://cassyni.com/events/BTYXxuAJF1vVXMFdHhQSH3/abstract https://cassyni-user-files-prod.s3.amazonaws.com/XaKVUGfutKWzc1xMJByDGA https://cassyni.com/slides/outline/43r6PGyK4WYRrUBnXVNsmw https://cassyni.com/events/43r6PGyK4WYRrUBnXVNsmw/abstract https://cassyni-user-files-prod.s3.amazonaws.com/CWHG5zTwGQJNNNdEcfh7v6 https://cassyni.com/events/43r6PGyK4WYRrUBnXVNsmw?videoPreview=1 The psychometrics of automatic speech recognitionnohttps://cassyni.com/events/43r6PGyK4WYRrUBnXVNsmw?videoPreview=12022-07-27T12:00:00+00:001294.6UK Metamaterials NetworkThis study investigates whether modern deep neural network (DNN) models of automatic speech recognition (ASR) serve as accurate models of the human auditory system by comparing their psychometric performance on manipulated speech stimuli. Three state-of-the-art ASR architectures were evaluated: a Kaldi model combining DNN with hidden Markov models using mel frequency cepstral coefficients (MFCCs), Mozilla DeepSpeech employing long short-term memory (LSTM) networks with MFCC inputs, and a more recent Wav2Vec model utilizing raw audio input with a convolutional neural network followed by a Transformer architecture. The models were tested on a range of auditory manipulations for which human psychometric data exist, including bandpass filtering, peak and center clipping, temporal fine structure (TFS) removal and restoration, and masker periodicity/fluctuations. Results consistently showed that humans outperform all ASR systems, particularly under distortions, and that the pattern of errors differs markedly between humans and models. Notably, none of the ASR models demonstrated sensitivity to TFS cues, despite the Wav2Vec model’s access to raw audio, while the CNN-Transformer architecture generally exhibited the closest performance to humans, especially in exploiting masker periodicity and fluctuations. These findings suggest that current ASR systems rely on mechanisms distinct from those used by the human auditory system, and that architectural differences, rather than training data volume alone, critically influence performance. The study highlights the importance of attention mechanisms and feature representations beyond MFCCs in approximating human auditory processing and provides an open-source framework for further comparative psychometric evaluation of ASR models.https://cassyni-user-files-prod.s3.amazonaws.com/CWHG5zTwGQJNNNdEcfh7v6 https://cassyni.com/slides/outline/ERTnMdZLH8ArNyUvYbKmTT https://cassyni.com/events/ERTnMdZLH8ArNyUvYbKmTT/abstract https://cassyni-user-files-prod.s3.amazonaws.com/KDmPRqVQTCQeefKuyMPftA https://cassyni.com/events/ERTnMdZLH8ArNyUvYbKmTT?videoPreview=1 Generative AI Industry Adoptionnohttps://cassyni.com/events/ERTnMdZLH8ArNyUvYbKmTT?videoPreview=12024-07-09T23:00:00+00:003373.0Business SchoolAnalysis of generative AI adoption trends reveals widespread employee engagement, with 75% globally and 84% in New Zealand utilizing AI tools at work, often bringing their own solutions. This adoption correlates with significant productivity uplifts, particularly for "power users" who can save nearly a day per month, and a strong demand for AI skills, with over three-quarters of New Zealand leaders preferring AI-proficient candidates. Generative AI applications are transforming beyond individual productivity to create organizational value through process optimization and automation. Microsoft's comprehensive Copilot suite, encompassing free online access, enterprise search, M365 integration, GitHub for developers, and Copilot for Security, exemplifies off-the-shelf solutions. Conversely, custom solutions are developed using tools like Azure AI Studio for tailored chatbots, prompt flow management, and content safety configurations, particularly for integrating with proprietary data and customer-facing applications. Specific industry applications include government initiatives (e.g., the Australian federal government's Copilot for M365 trial, New York City's data-prioritized chatbot), healthcare tools (e.g., Nuance DAX for ambient intelligence in consultations, cardiology literature solutions), educational platforms (e.g., Learning Accelerators for customized reading assignments, Khanmigo for AI-powered learning), and retail innovations (e.g., sales optimization, custom fashion assistants). Successful enterprise adoption necessitates a holistic strategy, prioritizing leadership engagement, human-centred change management (through education and demonstrating perceived value), and robust technical governance, underpinned by responsible AI principles, codified standards, implementation tools, and oversight mechanisms to ensure safe and effective integration.https://cassyni-user-files-prod.s3.amazonaws.com/KDmPRqVQTCQeefKuyMPftA https://cassyni.com/slides/outline/9Uyjto65tYdpysmaY7cmjK https://cassyni.com/events/9Uyjto65tYdpysmaY7cmjK/abstract https://cassyni-user-files-prod.s3.amazonaws.com/E4AKMjMWAQSHUdu5J6YsDQ https://cassyni.com/events/9Uyjto65tYdpysmaY7cmjK?videoPreview=1 The importance of technology representation at the board tablenohttps://cassyni.com/events/9Uyjto65tYdpysmaY7cmjK?videoPreview=12021-05-12T23:00:00+00:003640.4Business SchoolModern organisations face significant challenges due to insufficient technology representation and understanding at the board level. This analysis argues that technology is the core of contemporary business, necessitating a strategic and informed approach to IT governance. Drawing on extensive experience within a global logistics company, Mainfreight, an approach is outlined where the Chief Information Officer reports directly to the board, providing regular updates to foster technological literacy. The study highlights Mainfreight's operational model, which allocates approximately 2% of its over $3 billion revenue to IT spend, predominantly utilising bespoke, internally developed systems (98% own kit, 2% cloud) for cost efficiency and tailored functionality. Key findings indicate that robust disaster recovery and cybersecurity are critical, yet boards often struggle to appreciate these indirect investments. A logistics system developed for John Deere exemplifies proactive innovation, reducing supply chain time by one week, with 60% of orders arriving earlier than predicted. The analysis concludes that the absence of dedicated technology expertise on boards, coupled with a lack of comprehensive technology training for directors, leads to poor decision-making and increased project failure rates. Bridging this gap requires clear communication, a focus on internal talent development, and a fundamental shift in valuing technology as a strategic asset.https://cassyni-user-files-prod.s3.amazonaws.com/E4AKMjMWAQSHUdu5J6YsDQ https://cassyni.com/slides/outline/KMySw6YU54dsysU1LFKaVs https://cassyni.com/events/KMySw6YU54dsysU1LFKaVs/abstract https://cassyni-user-files-prod.s3.amazonaws.com/RtPdRRS2SDnzc6MAXzB6DL https://cassyni.com/events/KMySw6YU54dsysU1LFKaVs?videoPreview=1 MetaSilence - Controlling impact noise propagation with ceramic metatilesnohttps://cassyni.com/events/KMySw6YU54dsysU1LFKaVs?videoPreview=12025-06-17T05:00:00+00:001135.0ETOPIMThe propagation of impact noise through floor tiles presents a significant challenge in civil engineering, particularly in controlling vibrations generated by human activities. This study addresses the mitigation of such noise using ceramic metatiles designed as periodic structures composed of ceramic subtiles connected by silicone joints, forming a mass-spring system that exploits Bragg scattering and local resonances. Numerical simulations employing finite element methods with COMSOL, combined with experimental validation, characterize the elastic properties of the tiles and analyze wave dispersion and transmission. Dispersion curves reveal band gaps below 10 kHz, with particular attention to frequencies around 1 kHz relevant for impact noise. Parametric studies demonstrate that increasing the width of silicone joints significantly widens stop bands, enhancing attenuation. Transmission analyses for transverse and longitudinal waves indicate that metatiles reduce wave transmission by approximately 50–55 dB between 700 and 2500 Hz compared to standard ceramic tiles, with notable attenuation also observed from 500 to 700 Hz in experimental impact noise tests. These results confirm that the designed ceramic metatiles effectively suppress impact noise propagation within targeted frequency ranges, offering promising applications for noise control in flooring systems. The integration of numerical modeling and laboratory measurements provides a robust framework for optimizing metamaterial geometries and material properties to tailor acoustic performance in industrial and civil engineering contexts.https://cassyni-user-files-prod.s3.amazonaws.com/RtPdRRS2SDnzc6MAXzB6DL https://cassyni.com/slides/outline/XiBZ6Bib3WUjsYhpJbtJe1 https://cassyni.com/events/XiBZ6Bib3WUjsYhpJbtJe1/abstract https://cassyni-user-files-prod.s3.amazonaws.com/G8awkvQQmRs4aamhUcqgxW https://cassyni.com/events/XiBZ6Bib3WUjsYhpJbtJe1?videoPreview=1 An operator based approach to classifying topology in open and nonlinear systemsnohttps://cassyni.com/events/XiBZ6Bib3WUjsYhpJbtJe1?videoPreview=12025-06-19T01:00:00+00:001969.2ETOPIMIn this talk, I will provide an overview of some of the outstanding problems in the classification of topological materials in physical systems, and I will discuss how many of these problems can be addressed through the spectral localizer framework. For example, the chiral edge states that are guaranteed in systems with non-trivial Chern numbers hold great promise in photonic devices, where they can act as isolators or circulators in communications technologies. However, such photonic systems rarely conform to the idealized paradigm of a topological insulator adjacent to a trivial insulator. Instead, photonic systems usually abut air on at least one surface, into which the photons can radiate. Thus, many photonic systems instead resemble a topological insulator next to a “photonic metal,” i.e., a material that lacks a spectral gap for photons. As part of this talk, I will discuss how to classify such gapless heterostructures using the local markers in the spectral localizer framework, in both toy models as well as realistic systems described by differential operators. A second field of current interest in the photonic community is classifying the topology of non-linear systems, such as those described by a Gross–Pitaevskii equation. I will first illustrate how a localized state in such a system can exhibit atypical behavior, which has been experimentally observed. Then, I will demonstrate how the spectral localizer framework enables these input localized states to be topologically classified. Finally, I will also show how the spectral localizer framework can be directly applied to 2D electron gasses in semiconductor heterostructures, possibly patterned with antidot potentials. https://cassyni-user-files-prod.s3.amazonaws.com/G8awkvQQmRs4aamhUcqgxW https://cassyni.com/slides/outline/SH3uafbpDUPfUgTahgtWeZ https://cassyni.com/events/SH3uafbpDUPfUgTahgtWeZ/abstract https://cassyni-user-files-prod.s3.amazonaws.com/HirFVdrKrH1vTp4v8AXEnz https://cassyni.com/events/SH3uafbpDUPfUgTahgtWeZ?videoPreview=1 Relating topology and statistics of scattering singularities in inhomogeneous medianohttps://cassyni.com/events/SH3uafbpDUPfUgTahgtWeZ?videoPreview=12025-06-15T23:00:00+00:00615.2ETOPIMThe analysis explores the relationship between topology and the statistical behavior of scattering singularities in inhomogeneous media, focusing on wave scattering described by the scattering matrix in chaotic environments with multiple channels. Time delays, defined as frequency derivatives of functions related to the scattering matrix (notably the Wigner-Smith time delay), are shown to diverge precisely at phase singularities corresponding to coherent perfect absorption (CPA) conditions, reflectionless scattering modes (RSMs), and transmissionless scattering modes (TSMs). Experimental data from diverse systems—including tetrahedral graphs, chaotic billiards, and large cavities—demonstrate that when normalized by system-specific Heisenberg times, the probability density functions (PDFs) of various time delays exhibit universal power-law tails with an exponent of −3, independent of system dimensionality, channel number, symmetry class, or absorption. Topological analysis reveals that eigenvector coalescence points (exceptional points) and orthogonality points form stable structures—curves or loops in parameter space—that cannot spontaneously appear or vanish but only emerge or annihilate in pairs, reflecting constraints imposed by the two degrees of freedom of complex scalar fields. PDFs of functions diverging at these topological structures exhibit universal power laws of −2 or −3 depending on whether one or two degrees of freedom are constrained. Higher-order singularities formed by collisions of independent singularities lack topological protection and display system-dependent statistics. These findings establish a robust connection between the topology of scattering singularities and their universal statistical signatures, with implications for understanding wave dynamics in complex media.https://cassyni-user-files-prod.s3.amazonaws.com/HirFVdrKrH1vTp4v8AXEnz https://cassyni.com/events/5XpXdxRmnF8QLh1JRZyAm3/abstract https://cassyni-user-files-prod.s3.amazonaws.com/SM25VKDivXNBHvMbtBvAYE https://cassyni.com/events/CvUvzHYy4QEdEzybnztnbF/abstract https://cassyni-user-files-prod.s3.amazonaws.com/CG6RgNe7CaFYmnayRvbnYe https://cassyni.com/events/YBo7uaJKackx6k9AWG5AER/seminar/qa https://cassyni.com/slides/outline/YBo7uaJKackx6k9AWG5AER https://cassyni.com/events/YBo7uaJKackx6k9AWG5AER/abstract https://cassyni-user-files-prod.s3.amazonaws.com/CGjakTkafYfax8oJhC5LFx https://cassyni.com/events/YBo7uaJKackx6k9AWG5AER?videoPreview=1 Inflammation-Mediated Mechanisms of Endothelial Dysfunctionnohttps://cassyni.com/events/YBo7uaJKackx6k9AWG5AER?videoPreview=12026-05-06T13:00:00+00:004483.56The Pharmacological Research family of journalsEndothelial dysfunction is a hallmark of nearly all cardiovascular and metabolic diseases, serving as a critical link between inflammation and vascular injury. This presentation will explore how inflammatory mediators, ranging from cytokines and oxidative stress to platelet and leukocyte activation, disrupt endothelial homeostasis, impair nitric oxide signaling, and promote vascular remodeling. Drawing on recent discoveries from our laboratory and others, I will highlight molecular mechanisms linking chronic inflammation to endothelial barrier dysfunction, thrombosis, and altered vascular tone.https://cassyni-user-files-prod.s3.amazonaws.com/CGjakTkafYfax8oJhC5LFx https://cassyni.com/events/Kqcds7e61Xqs2mMyjaLc1B/seminar/qa https://cassyni.com/slides/outline/Kqcds7e61Xqs2mMyjaLc1B https://cassyni.com/events/Kqcds7e61Xqs2mMyjaLc1B/abstract https://cassyni-user-files-prod.s3.amazonaws.com/XWUjLnBbBkuxQEyRCg3CGE https://cassyni.com/events/Kqcds7e61Xqs2mMyjaLc1B?videoPreview=1 Transport phenomena in microswimmer suspensionsnohttps://cassyni.com/events/Kqcds7e61Xqs2mMyjaLc1B?videoPreview=12026-04-02T09:00:00+00:003624.04Journal of Fluid MechanicsSuspensions of microswimmers exhibit distinct characteristics as compared to those of passive particles because the internal particles are in a state of spontaneous motion. Although there have been many studies of microswimmer suspensions, not many have carefully considered the hydrodynamics. Hydrodynamics becomes particularly important when discussing non-dilute suspensions, because the lubrication flow generates a large force when the swimmers are in close proximity. This talk focuses on hydrodynamics and describes the transport phenomena of microswimmer suspensions, such as migration, collective motion, diffusion and rheology. The talk is structured to progressively scale up from a single microswimmer to collective motion to a macroscale continuum. At each scale, the discussion also evolves from dilute to concentrated suspensions. We first introduce natural swimming microorganisms, artificial microswimmers and mathematical models, as well as the fundamentals of fluid mechanics relevant to microswimmers. We then describe the migration of microswimmers by taxis, where microswimmers respond passively or actively to their hydrodynamic environment. Microswimmers exhibit collective motions, the mechanism of which is discussed in terms of hydrodynamics. The spreading of microswimmers is often diffusive, and the diffusion coefficient is much larger than for passive particles. Similarly, the mass diffusivity in microswimmer suspensions is higher due to their swimming activity. We explain these macroscopic diffusion properties. The viscosity of microswimmer suspensions can be higher or lower depending on the characteristics and orientation of the microswimmers. We describe the rheological properties of microswimmer suspensions in shear flow and Poiseuille flow. Finally, current issues and future research perspectives are discussed.https://cassyni-user-files-prod.s3.amazonaws.com/XWUjLnBbBkuxQEyRCg3CGE https://cassyni.com/events/WDEKqUE7E9UHZGf7kgHVgh/seminar/qa https://cassyni.com/slides/outline/WDEKqUE7E9UHZGf7kgHVgh https://cassyni.com/events/WDEKqUE7E9UHZGf7kgHVgh/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Tq6dWUDH8jQTTwXndcHy2N https://cassyni.com/events/WDEKqUE7E9UHZGf7kgHVgh?videoPreview=1 MOSBRI Outcomes: Advancing Molecular Biophysics Through Shared Data, Tools and Infrastructurenohttps://cassyni.com/events/WDEKqUE7E9UHZGf7kgHVgh?videoPreview=12026-04-08T11:00:00+00:005153.4Springer Nature Physics CommunityThe Molecular-Scale Biophysics Research Infrastructure (MOSBRI) project addressed the need for enhanced European-level coverage of molecular-scale biophysics, a field situated between atomic-resolution structural biology and cellular imaging. This initiative fostered community building through networking, training, and joint research activities, providing transnational access to 25 distinct technologies, including real-time biosensing, advanced spectroscopies, hydrodynamic, thermodynamic, and single-molecule approaches. Over its four-year span, MOSBRI attracted more than 250 applications for access and engaged nearly 1000 participants across 4 international conferences, 14 training schools, and 4 benchmarking actions. Key outcomes include the development of the eSPC software suite and the Molecular Biophysics Database (MBDB). The eSPC suite is a web-based, open-source platform offering user-friendly data analysis tools for techniques such as microscale thermophoresis (MST), differential scanning fluorimetry (DSF), dynamic light scattering (DLS), circular dichroism (CD), biolayer interferometry (BLI), and mass photometry (MP). Ongoing development focuses on integrating artificial intelligence via MCP servers for enhanced, high-throughput analysis, exemplified by the CheMelt tool for global analysis of chemical and thermal denaturation in DSF, which revealed that a reduced heat capacity of unfolding is a mechanism for achieving higher thermal stability in designed proteins. The MBDB serves as a public, FAIR (Findable, Accessible, Interoperable, Reusable) repository for raw biophysical data, standardizing formats and enabling cross-method searches for ITC, BLI, MST, and SPR data, with MP integration underway. It employs precise chemistry definitions and unique persistent identifiers. The formation of the Association of Resources for Biophysical Research in Europe (ARBRE) as a legal entity ensures the continuity of MOSBRI’s community-building efforts.https://cassyni-user-files-prod.s3.amazonaws.com/Tq6dWUDH8jQTTwXndcHy2N https://cassyni.com/events/RGkHNdkrqZwGAAwmkCaVxZ/seminar/qa https://cassyni.com/slides/outline/RGkHNdkrqZwGAAwmkCaVxZ https://cassyni.com/events/RGkHNdkrqZwGAAwmkCaVxZ/abstract https://cassyni-user-files-prod.s3.amazonaws.com/WBfRF7c5WQPtuWTPGTtE2S https://cassyni.com/events/RGkHNdkrqZwGAAwmkCaVxZ?videoPreview=1 Maxwell’s equations with hypersingularities at a negative index material conical tipnohttps://cassyni.com/events/RGkHNdkrqZwGAAwmkCaVxZ?videoPreview=12026-02-17T14:00:00+00:004769.92MetaMATIn this talk, we are interested in the analysis of time-harmonic Maxwell’s equations in presence of a conical tip of a material with negative dielectric constants. When these constants belong to some critical range, the electromagnetic field exhibits strongly oscillating singularities at the tip which have infinite energy. Consequently Maxwell’s equations are not well-posed in the classical $L^2$ framework. The goal of the present work is to provide an appropriate functional setting for 3D Maxwell’s equations when both the dielectric permittivity and the magnetic permeability take critical values. Following what has been done for the 2D scalar case, the idea is to work in weighted Sobolev spaces, adding to the space the so-called outgoing propagating singularities. The analysis requires new results of scalar and vector potential representations of singular fields. The outgoing behaviour is selected via the limiting absorption principle.https://cassyni-user-files-prod.s3.amazonaws.com/WBfRF7c5WQPtuWTPGTtE2S https://cassyni.com/events/2ZxXUV4WYrjb8ThFa1iBQR/seminar/qa https://cassyni.com/slides/outline/2ZxXUV4WYrjb8ThFa1iBQR https://cassyni.com/events/2ZxXUV4WYrjb8ThFa1iBQR/abstract https://cassyni-user-files-prod.s3.amazonaws.com/YM94dQ5YEXwUEyWsVsYoHG https://cassyni.com/events/2ZxXUV4WYrjb8ThFa1iBQR?videoPreview=1 The Middle East as a natural laboratory to advance our understanding of global hyperarid drylandsnohttps://cassyni.com/events/2ZxXUV4WYrjb8ThFa1iBQR?videoPreview=12025-10-22T13:00:00+00:001892.12Cambridge PrismsHyperarid drylands, though often perceived as barren, harbor exceptional biodiversity and sustain millions of people. Yet they remain among the least studied ecosystems on Earth. This talk will highlight how advancing research in the Middle East’s hyperarid regions can improve understanding of dryland ecology globally. I will discuss how large-scale greening initiatives provide an unprecedented opportunity to study ecosystem function, resilience, and adaptation to change. Establishing a coordinated research and monitoring framework would not only guide conservation and restoration but also support sustainable development and climate resilience in the world’s most arid environments.https://cassyni-user-files-prod.s3.amazonaws.com/YM94dQ5YEXwUEyWsVsYoHG https://cassyni.com/slides/outline/PnibthGdK7VTxw3pzLNAEq https://cassyni.com/events/PnibthGdK7VTxw3pzLNAEq/abstract https://cassyni-user-files-prod.s3.amazonaws.com/5RiXHzPDYz9niGYfCp9cH4 https://cassyni.com/events/PnibthGdK7VTxw3pzLNAEq?videoPreview=1 Educational Infrastructure: The Foundation for a Successful Curriculum Renewalnohttps://cassyni.com/events/PnibthGdK7VTxw3pzLNAEq?videoPreview=12024-04-17T08:00:00+00:003615.84AAMCIn this session, we will discuss some of the common resources (e.g. people, space, technology, tools, and governing structures) needed during almost any curriculum change process. We will highlight potential mistakes leaders make when embarking on curriculum renewal without considering these infrastructure needs. We will provide a general framework for thinking about the kinds of resources you may need when embarking on a curriculum change initiative and discuss ways you may be able to estimate the associated costs. We will discuss the importance of negotiating appropriately to secure resources and infrastructure and how to pivot if those resource needs cannot be met. Using the recent curriculum renewal process at Washington University School of Medicine as an example, we will provide details of the infrastructure required and answer questions from audience members about their planning processes and potential resource needs. This webinar is part of the Building Better Curriculum Series, hosted by the AAMC. For more information on the complete series, see the [series webpage](https://www.aamc.org/about-us/mission-areas/medical-education/curriculum-resources/establish-your-ci/webinars).  https://cassyni-user-files-prod.s3.amazonaws.com/5RiXHzPDYz9niGYfCp9cH4 https://cassyni.com/slides/outline/VDrFQDPQ99as6Ldczxc4CD https://cassyni.com/events/VDrFQDPQ99as6Ldczxc4CD/abstract https://cassyni-user-files-prod.s3.amazonaws.com/7ZBgfhQ6pDGfXhbQ7Q44bQ https://cassyni.com/events/VDrFQDPQ99as6Ldczxc4CD?videoPreview=1 Case Studiesnohttps://cassyni.com/events/VDrFQDPQ99as6Ldczxc4CD?videoPreview=12021-06-02T08:00:00+00:001239.32 School of Public PolicyThe case method, originating in legal education, offers a robust framework for engaging with complex, real-world problems across diverse fields, including business and technology. This approach emphasizes problem-based learning by immersing students in detailed scenarios that foreground ethical, social, and practical dilemmas without reducing them to binary outcomes. Case studies grounded in recent, relevant events enhance student engagement and enable the application of theoretical ethical frameworks to tangible situations, thereby bridging the gap between abstract philosophy and practical decision-making. Exemplified by a labor case study on the Rana Plaza disaster, the method integrates historical context with contemporary challenges, fostering nuanced discussions on issues such as global labor conditions, economic necessity, and moral responsibility. This case also illustrates how technological advancements, like robotics, complicate ethical considerations by introducing trade-offs between innovation and social impact. The method’s adaptability extends to emerging technological domains, including machine vision, gene editing (e.g., CRISPR), and public health interventions, where ethical questions transcend scientific data and require multidisciplinary perspectives. The development of effective cases benefits from subject-matter expertise, ensuring depth and relevance, and is an iterative process responsive to classroom dynamics. The case method encourages critical thinking beyond profit maximization and compliance, promoting ethical reflection as integral to professional practice. Resources for case studies in technology ethics remain limited but are growing, with institutions like UT Austin providing valuable repositories. Overall, the case method serves as a dynamic pedagogical tool to cultivate ethical literacy and complex problem-solving skills in technology and related disciplines.https://cassyni-user-files-prod.s3.amazonaws.com/7ZBgfhQ6pDGfXhbQ7Q44bQ https://cassyni.com/slides/outline/RmK25Rrj4wiE4eL4MJE6fP https://cassyni.com/events/RmK25Rrj4wiE4eL4MJE6fP/abstract https://cassyni-user-files-prod.s3.amazonaws.com/BWPZL6nCHd1vUSwnmTJJAi https://cassyni.com/events/RmK25Rrj4wiE4eL4MJE6fP?videoPreview=1 The President and Economic Leadership: What Can the Gilded Age Tell Us?nohttps://cassyni.com/events/RmK25Rrj4wiE4eL4MJE6fP?videoPreview=12021-03-02T09:00:00+00:005287.16 School of Public PolicyDo presidents matter for America’s economic performance? This talk looks for answers in a set of least-likely cases: the Gilded Age presidents (1869-1901). The conventional wisdom is that prior to Theodore Roosevelt, presidents mattered little during peacetime. One reason is that the 19th century public expected little of its executives. And even if a president had wanted to affect policy, most observers argue that the Gilded Age presidency was too institutionally weak to do much. We also tend to stereotype Gilded Age presidents as ineffective, irrelevant, and forgettable. However, this talk will show that Gilded Age presidents were often dynamic, influential, and affected the nation’s economy in subtle ways that still apply today. Hence, this investigation is more than just an academic debate over long-dead politicians. While the differences might tempt us to dismiss this time period as irrelevant, the similarities between the Gilded Age and today are even more striking.https://cassyni-user-files-prod.s3.amazonaws.com/BWPZL6nCHd1vUSwnmTJJAi https://cassyni.com/slides/outline/525e8iggdiSxvesn5BJkms https://cassyni.com/events/525e8iggdiSxvesn5BJkms/abstract https://cassyni-user-files-prod.s3.amazonaws.com/6qv9TGPQ6W2GZviBbZ2VFU https://cassyni.com/events/525e8iggdiSxvesn5BJkms?videoPreview=1 Building Analogies: In Vitro Simulation Modeling in Biomedical Engineering Sciencesnohttps://cassyni.com/events/525e8iggdiSxvesn5BJkms?videoPreview=12021-08-03T08:00:00+00:004720.32 School of Public PolicyThis analysis examines the epistemic role of in vitro simulation modeling within Biomedical Engineering Sciences (BME), focusing on how such models are incrementally and iteratively constructed as analogical sources to understand and control complex biological systems. Unlike traditional analogical reasoning, which relies on retrieving pre-existing source analogies, BME researchers build these analogical models from the ground up in contexts where both the source and target systems are poorly understood and lack comprehensive theoretical frameworks. The study draws on cognitive ethnographies of pioneering university labs engaged in tissue and neural engineering, highlighting how hybrid model systems—comprising biological materials interfaced with engineered devices—serve as functional exemplifications of selected in vivo phenomena. These models, such as flow loops simulating shear forces on endothelial cells and tissue-engineered vascular constructs, are evaluated continuously for their capacity to instantiate biologically relevant features while managing simplifications and negative analogies. The process of building these models is characterized as a bootstrapping epistemic practice that integrates biological and engineering knowledge to create nested analogies within complex dynamical systems. The warrant for transferring experimental inferences from model to target relies on the models’ exemplification of relevant features rather than on notions of similarity or truth. This framework underscores the creative and constructive nature of analogical modeling in frontier biomedical research, emphasizing its significance for advancing both conceptual understanding and practical intervention despite ongoing uncertainties and ethical constraints.https://cassyni-user-files-prod.s3.amazonaws.com/6qv9TGPQ6W2GZviBbZ2VFU https://cassyni.com/slides/outline/7VKfN8vJq1DTHbMLcsDPVo https://cassyni.com/events/7VKfN8vJq1DTHbMLcsDPVo/abstract https://cassyni-user-files-prod.s3.amazonaws.com/2tRHXqMw4bXJcdFj9zChAn https://cassyni.com/events/7VKfN8vJq1DTHbMLcsDPVo?videoPreview=1 Interaction between Coherent Whistler Waves and Energetic Particles in the Magnetosphere and its Exploitation for Runaway Electron Suppression in Tokamaksnohttps://cassyni.com/events/7VKfN8vJq1DTHbMLcsDPVo?videoPreview=12025-08-07T06:00:00+00:002731.24Journal of Plasma PhysicsRecent spacecraft observations indicate that whistler mode chorus subelements are extremely coherent, i.e., are monochromatic and phase-aligned. In such cases, popular diffusion mechanisms such as the quasi-linear mechanism that requires a broadband wave spectrum are invalid, and coherent wave-particle interactions must be examined. It is shown that the vector relativistic equation of motion of a particle under a circularly polarized electromagnetic wave can be reduced to a scalar conservative equation of motion of a resonance mismatch parameter. This equation of motion involves a conserved pseudo-energy in a pseudo-potential, whose shape if double-welled can lead to a rapid, extreme scattering, which is often observed in the magnetosphere. This mechanism can then be leveraged to construct a "momentum firewall" for hazardous runaway electrons in tokamaks, wherein the accelerating electrons are prevented from gaining parallel momentum upon hitting the firewall and are instantaneously scattered in momentum space. This method is further verified by self-consistent particle-in-cell simulations.https://cassyni-user-files-prod.s3.amazonaws.com/2tRHXqMw4bXJcdFj9zChAn https://cassyni.com/slides/outline/EQQ81hyeyQyEnQLuzJnKeV https://cassyni.com/events/EQQ81hyeyQyEnQLuzJnKeV/abstract https://cassyni-user-files-prod.s3.amazonaws.com/6jGxLRdYKXttaAQjKsuidt https://cassyni.com/events/EQQ81hyeyQyEnQLuzJnKeV?videoPreview=1 Burning plasma physics studies on JETnohttps://cassyni.com/events/EQQ81hyeyQyEnQLuzJnKeV?videoPreview=12024-02-08T06:00:00+00:003102.32Journal of Plasma PhysicsThe era of burning magnetically confined plasmas is on the horizon. The optimization of plasma scenarios for stability and performance will have to be re-learned when a large population of alpha particles drives kinetic instabilities and produces the majority of the heating. A primary mission of the JET tokamak was to successfully confine alpha particles to allow the study of their behaviour, with JET being one of only two tokamaks to have ever operated with deuterium-tritium (DT) fuelling. In this talk, we discuss recently published results from JET experiments that give glimpses into future alpha particle effects, such as destabilization of Alfven eigenmodes, electron heating, and losses. https://cassyni-user-files-prod.s3.amazonaws.com/6jGxLRdYKXttaAQjKsuidt https://cassyni.com/slides/outline/Eu3j4PdBQsXHnAsoak57uo https://cassyni.com/events/Eu3j4PdBQsXHnAsoak57uo/abstract https://cassyni-user-files-prod.s3.amazonaws.com/ND4eqEoCuui9zEwbgwPpL6 https://cassyni.com/events/Eu3j4PdBQsXHnAsoak57uo?videoPreview=1 Structure formation in magnetohydrodynamic turbulence as a modulational instabilitynohttps://cassyni.com/events/Eu3j4PdBQsXHnAsoak57uo?videoPreview=12023-12-14T06:00:00+00:003371.48Journal of Plasma PhysicsStructure formation in magnetohydrodynamic (MHD) turbulence is a problem that has long been of interest, for example, in the context of turbulent dynamo and other types of self-organization of astrophysical and laboratory plasmas. Its onset can be approached as an instability of a statistical equilibrium with respect to a small perturbation. Such modulational instabilities (MIs) can be described much like familiar linear plasma instabilities in kinetic theory, except the role of mean fields there is played by coherent structures (such as an average magnetic field), and the role of plasma particles is played by the turbulent background fluctuations. Although local closures for the electromotive force are the current standard in mean-field dynamo theories, scale separation is far from guaranteed and quantumlike wave-kinetic theory, generally known as Wigner-Moyal kinetics, is needed instead. In the past, this framework has proven fruitful for studies of drift-wave and other types of turbulence, even within the quasilinear approximation (QLA), or collisionless-wave approximation. We show that although quasilinear Wigner-Moyal kinetics yields quantitatively accurate predictions for MHD in some regimes, remarkably, in adjacent regimes QLA can be inaccurate even qualitatively. This raises the question: what is the cause of such dramatic variations? We explore this question within two-dimensional incompressible MHD assuming simple nonlinear backgrounds that allow for a tractable model without truncating the modulational spectrum. We find that, although MI modes are typically assumed to be exponentially localized in the spectral space, i.e. have the form of evanescent spectral waves, this assumption is violated for some parameters. Then, MI modes become propagating spectral waves (PSWs) instead. PSWs have a constant amplitude and thus provide efficient ballistic energy transport down the modulational spectrum, something that is not captured by a typical wave-wave collision operator. Once transients have dissipated, PSWs are self-maintained as global modes with specific real frequencies and drain energy from the primary structure at a constant rate until the primary structure is depleted. The presence of PSWs thereby introduces dissipation to almost any nonlinear MHD wave even at arbitrarily small viscosity; this suppresses MIs in regimes where QLA would predict instabilities. Although PSWs cannot be captured by naive truncations, it may be possible to accommodate them with a proper closure. Finally, we find that introducing dispersion or dissipation constrains the scaling of modulational modes, suppressing PSWs and reinstating the accuracy of QLA. In this sense, ideal MHD is a "singular" system that is particularly sensitive to the accuracy of the closure within mean-field models.https://cassyni-user-files-prod.s3.amazonaws.com/ND4eqEoCuui9zEwbgwPpL6 https://cassyni.com/events/9Tv5YsWQaqSDPJdZyq5KvM/abstract https://cassyni-user-files-prod.s3.amazonaws.com/14JhuaN5ntNUcuQfVYj8WJ https://cassyni.com/slides/outline/Mp9opbCQxeCoRm9dCbBpvH https://cassyni.com/events/Mp9opbCQxeCoRm9dCbBpvH/abstract https://cassyni-user-files-prod.s3.amazonaws.com/UPMoGdih5kJ3roxUnL2jqY https://cassyni.com/events/Mp9opbCQxeCoRm9dCbBpvH?videoPreview=1 From AI to Robots - Representational Technologies of the Humannohttps://cassyni.com/events/Mp9opbCQxeCoRm9dCbBpvH?videoPreview=12023-12-06T09:00:00+00:003672.0Palgrave MacmillanThis seminar addresses the evolving intersection of artificial intelligence (AI), robotics, and the humanities, emphasizing the critical role of representational technologies in shaping human self-understanding and societal norms. The discussion foregrounds the concept of “representational technologies of the human,” defined as diverse forms of images and symbols—ranging from fictional narratives to physical robotic artifacts—that reproduce and mediate ideas about human identity, particularly focusing on gendered and sexualized representations of women. Drawing on anthropological and philosophical frameworks, the analysis reveals how these technologies perpetuate power imbalances and cultural narratives, such as the subservience and objectification of women, across both fictional and material domains. The seminar also highlights the ethical challenges and opportunities posed by AI integration in academic publishing and broader social contexts. It showcases a human-centered, collaborative approach to AI-assisted knowledge production, emphasizing the augmentation rather than replacement of human expertise. Furthermore, it underscores the importance of interdisciplinary scholarship—spanning ethics, philosophy, music, and communication studies—in critically examining AI’s societal impacts, including bias, inequality, and the preservation of human values. Governance frameworks and ethical oversight within publishing and technological development are presented as essential mechanisms to ensure responsible AI use. The seminar concludes by advocating for continued critical engagement with AI and robotics through humanities and social sciences perspectives to foster equitable, ethical, and culturally informed technological futures.https://cassyni-user-files-prod.s3.amazonaws.com/UPMoGdih5kJ3roxUnL2jqY https://cassyni.com/slides/outline/SFzFEk28umC3tQuR7ExQ4m https://cassyni.com/events/SFzFEk28umC3tQuR7ExQ4m/abstract https://cassyni-user-files-prod.s3.amazonaws.com/X3sv8AMPPmG1eNA8FAxgcE https://cassyni.com/events/SFzFEk28umC3tQuR7ExQ4m?videoPreview=1 How far does turbulence spread?nohttps://cassyni.com/events/SFzFEk28umC3tQuR7ExQ4m?videoPreview=12025-10-29T14:00:00+00:002506.12Department of AeronauticsIn this talk I will discuss how turbulence can spread in space in the absence of mean momentum injection. I will present results from direct numerical simulations of a turbulent flow in a long triply periodic box generated by a forcing that is localized in space. At long times a statistically stationary state is reached where the turbulent energy density in space fluctuates around a mean profile that peaks at the forcing location and decreases fast away from it. We measure this profile as a function of the distance from the forcing region for different values of the Reynolds number. It is shown that, as the Reynolds number is increased, it converges to a Reynolds-number-independent profile, implying that turbulence spreads due to self-advection and not due to molecular diffusion. In this limit, therefore, turbulence plays the simultaneous role of cascading the energy to smaller scales and transporting it to larger distances. The two effects are shown to be of the same order of magnitude. Thus a new turbulent state is reached where turbulent transport and turbulent cascade are equally important and control its properties.https://cassyni-user-files-prod.s3.amazonaws.com/X3sv8AMPPmG1eNA8FAxgcE https://cassyni.com/slides/outline/FPixDhnbFh17bwTALgoRKB https://cassyni.com/events/FPixDhnbFh17bwTALgoRKB/abstract https://cassyni-user-files-prod.s3.amazonaws.com/NAq5f8xsF4Sn92kw37gYRU https://cassyni.com/events/FPixDhnbFh17bwTALgoRKB?videoPreview=1 How Artificial Intelligence could be used towards the sustainable Management of existing infrastructuresnohttps://cassyni.com/events/FPixDhnbFh17bwTALgoRKB?videoPreview=12025-09-15T07:00:00+00:003178.84ArtIStE - Artificial Intelligence in Structural EngineeringArtificial Intelligence (AI) can significantly enhance the sustainable management of existing infrastructures through various applications, including, among others: (i) Predictive Maintenance: AI algorithms analyse data to predict failures before they occur, reducing downtime and extending infrastructure lifespan while minimizing resource use; (ii) Multicriteria Optimization: AI models optimize the decisions concerning operation and maintenance of infrastructures, leading to reduced carbon footprints; (iii) Asset Monitoring and Inspection: Using AI-powered image and video analysis (e.g., drone, CCTV), infrastructure components like bridges, roads, and pipelines can be regularly inspected for damages or degradation, enabling timely repairs and extending their lifetime; and (iv) Integration with IoT and Big Data: Combining AI with IoT devices and large datasets enables real-time decision-making, proactive maintenance, and adaptive operations aligned with sustainability goals. By leveraging these AI-driven approaches, it is possible to manage infrastructure more sustainably, reducing environmental impact, and extending infrastructure lifespan—all while maintaining safety and efficiency.https://cassyni-user-files-prod.s3.amazonaws.com/NAq5f8xsF4Sn92kw37gYRU https://cassyni.com/slides/outline/NoUe2b1MEvEgEzg2b8bbMo https://cassyni.com/events/NoUe2b1MEvEgEzg2b8bbMo/abstract https://cassyni-user-files-prod.s3.amazonaws.com/RW9VCTNNJuT7upr8zFKqBC https://cassyni.com/events/NoUe2b1MEvEgEzg2b8bbMo?videoPreview=1 Bridging innovation and adoption: understanding farmers' preferences for Agrobacterium-mediated transformation in gene-edited tomato cultivars in Nigerianohttps://cassyni.com/events/NoUe2b1MEvEgEzg2b8bbMo?videoPreview=12025-08-05T13:45:00+00:005756.72NoneAdvancements in plant biotechnology, including *Agrobacterium*-mediated transformation and gene editing, offer immense potential to enhance food security and agricultural sustainability in developing regions. This research leverages CRISPR-Cas9 gene editing to address challenges in tomato (*Solanum lycopersicum*) production in Nigeria, including low productivity, high post-harvest losses, and limited adoption of advanced technologies. Tomatoes are crucial for nutrition and livelihoods, but their short shelf life exacerbates food insecurity and financial instability for farmers. This study focused on designing and implementing CRISPR-Cas9 constructs to target the *Shelf-Life Food Regulator* (*SlFSR*) gene in two tomato varieties, Pusa Ruby and UC82, to extend post-harvest shelf life. Precise editing involved selecting optimal target sites within the *SlFSR* gene and optimizing guide RNA sequences. CRISPR-Cas9 cassettes were PCR-amplified, cloned, ligated, and introduced into tomato varieties via *Agrobacterium*-mediated transformation protocols, achieving high efficiency (~85%). Field surveys across three Nigerian states revealed socio-economic factors influencing technology adoption, such as gender disparities and reliance on rain-fed agriculture. This research demonstrates the potential of integrating socio-economic insights with precision genetic tools to enhance shelf life, stress tolerance, and fruit quality contributing to sustainable agriculture and food security.https://cassyni-user-files-prod.s3.amazonaws.com/RW9VCTNNJuT7upr8zFKqBC https://cassyni.com/slides/outline/Qn54DKbSzkTSLhxFx6TXnM https://cassyni.com/events/Qn54DKbSzkTSLhxFx6TXnM/abstract https://cassyni-user-files-prod.s3.amazonaws.com/GDAQdvfvGmiHm9JXL8oB8a https://cassyni.com/events/Qn54DKbSzkTSLhxFx6TXnM?videoPreview=1 Keeping the Humanities Visible in Scholarly Publishingnohttps://cassyni.com/events/Qn54DKbSzkTSLhxFx6TXnM?videoPreview=12026-01-14T10:30:00+00:003734.48Academic Publishing in EuropeIn academic publishing, many developments of recent decades have been driven by STM disciplines: from journal digitization and new business models to metadata standards, peer review best practices, and research funding principles. Humanities publishers have both benefited from and been constrained by this evolution. While STM innovations have proven valuable, many requirements suited to STM have been imposed on humanities publishing and funding despite being a poor fit. This has created the misperception that humanities publishing is slow and not innovative—a view that, combined with beliefs about STM’s superior economic impact, has increased funding pressure on the humanities. This session challenges these perceptions as not only unfair but fundamentally wrong. The humanities’ distinct pace reflects the specificities of these disciplines, which differ fundamentally from STM: focus on culture (language-sensitive) rather than global scope (with English as lingua franca); long discourses with extended lifecycles (where monographs excel) rather than short-lived discoveries (suited to journal articles); and emphasis on individual scholarship rather than collaborative research teams. These differences must be recognized when evaluating and developing publishing and funding models for the humanities. Beyond raising awareness of the humanities’ distinct value and publication ecosystem, this session aims to develop practical solutions to these challenges.https://cassyni-user-files-prod.s3.amazonaws.com/GDAQdvfvGmiHm9JXL8oB8a https://cassyni.com/events/QH5yo5mHixnJB9NveCAGUD/seminar/qa https://cassyni.com/slides/outline/QH5yo5mHixnJB9NveCAGUD https://cassyni.com/events/QH5yo5mHixnJB9NveCAGUD/abstract https://cassyni-user-files-prod.s3.amazonaws.com/DSKmiSefcPGE9bUrof6oVg https://cassyni.com/events/QH5yo5mHixnJB9NveCAGUD?videoPreview=1 Breaking Symmetry: Strategies for Acoustic and Elastic Wave Control in Metamaterialsnohttps://cassyni.com/events/QH5yo5mHixnJB9NveCAGUD?videoPreview=12026-03-24T14:00:00+00:004088.48MetaMATControlling the propagation of waves is a ubiquitous objective in various fields, including electromagnetics, acoustics, and mechanics. In the last decade, this ever-present challenge has motivated research in wave physics and materials science. Particularly, in elastodynamics, the presence of coupling and hybridization between distinct types of modes, such as longitudinal and shear waves, allows richer possibilities of manipulation. In this context, architected materials (or metamaterials) serve as an ideal playground for designing versatile media with tailored wave-controlling properties. Their resulting superior control over elastic and acoustic waves has enabled a wide range of applications spanning several length scales, such as noise reduction, non-destructive testing, and seismic vibration shielding. In this talk, we demonstrate how elastic and acoustic waves can be manipulated on diverse platforms aiming at distinct objectives but based on a fundamental design strategy: breaking the underlying spatial symmetry in one- and two-dimensional periodic systems to enable tailored dispersion properties.https://cassyni-user-files-prod.s3.amazonaws.com/DSKmiSefcPGE9bUrof6oVg https://cassyni.com/events/GsMv6q4R96UnR7C262Ye29/seminar/qa https://cassyni.com/slides/outline/GsMv6q4R96UnR7C262Ye29 https://cassyni.com/events/GsMv6q4R96UnR7C262Ye29/abstract https://cassyni-user-files-prod.s3.amazonaws.com/UrKtGURwChsaozTZEgJYcW https://cassyni.com/events/GsMv6q4R96UnR7C262Ye29?videoPreview=1 Shrinking the optical path: How to model a spaceplate via Huygens' metasurfacesnohttps://cassyni.com/events/GsMv6q4R96UnR7C262Ye29?videoPreview=12026-03-17T14:00:00+00:003797.52MetaMATSpaceplates have emerged in the context of nonlocal metasurfaces, enabling the compression of optical systems by minimizing the required empty space between their components. In this talk, we present our advances in designing and analyzing spaceplates that support resonances with opposite symmetries, operating under the so-called Huygens’ condition. Using the temporal coupled-mode theory, we demonstrate that the spatial compression provided by Huygens’ spaceplates is twice that of conventional single-resonance counterparts. Additionally, they can support broader operational bandwidths and numerical apertures, facilitating the reduction of chromatic aberrations. Moreover, Huygens’ spaceplates maintain nearly full transparency over a wide frequency and angular range, allowing their straightforward cascading for multi-frequency broadband operation. Finally, we propose a physical implementation of a Huygens’ spaceplate for optical frequencies based on a photonic crystal slab geometry.https://cassyni-user-files-prod.s3.amazonaws.com/UrKtGURwChsaozTZEgJYcW https://cassyni.com/slides/outline/TFK5Sjq5C3DvheRpVnNAWH https://cassyni.com/events/TFK5Sjq5C3DvheRpVnNAWH/abstract https://cassyni-user-files-prod.s3.amazonaws.com/LumpApdKZZeeSUEZED2JHL https://cassyni.com/events/TFK5Sjq5C3DvheRpVnNAWH?videoPreview=1 Making Peer Review Better for Researchers: What do article authors and readers want from peer review?nohttps://cassyni.com/events/TFK5Sjq5C3DvheRpVnNAWH?videoPreview=12026-02-24T12:10:00+00:002891.44Researcher to ReaderWhat really helps researchers both as authors and readers? We will look at some new ideas coming from researchers themselves both in traditional and non-traditional areas. How can peer review better serve authors in making the process faster and more efficient, perhaps even by starting further back in the research process? how can we harness the huge volume of new researchers in Asia to support the global pool of peer reviewers? And what do ECRs need from the peer review process to ensure their trust in the scholarly record? We are keen to hear ideas from the audience on how they might work with some of these ideas.https://cassyni-user-files-prod.s3.amazonaws.com/LumpApdKZZeeSUEZED2JHL https://cassyni.com/events/33YUBF8Mgc62Xxfya14s5w/seminar/qa https://cassyni.com/slides/outline/33YUBF8Mgc62Xxfya14s5w https://cassyni.com/events/33YUBF8Mgc62Xxfya14s5w/abstract https://cassyni-user-files-prod.s3.amazonaws.com/CECNT632tNaBw3hm1XFHZG https://cassyni.com/events/33YUBF8Mgc62Xxfya14s5w?videoPreview=1 Walzer and Justice: Spheres of Justice in the 2020snohttps://cassyni.com/events/33YUBF8Mgc62Xxfya14s5w?videoPreview=12025-11-23T18:00:00+00:004479.4Research Seminars by Springer NatureJoin us for a discussion of the newly published book *Walzer and Justice: Spheres of Justice in the 2020s*, a collection of essays that reinterpret and reimagine Michael Walzer’s classic work *Spheres of Justice*. https://cassyni-user-files-prod.s3.amazonaws.com/CECNT632tNaBw3hm1XFHZG https://cassyni.com/slides/outline/DRAA9biNuDiT4Ty7b71kmT https://cassyni.com/events/DRAA9biNuDiT4Ty7b71kmT/abstract https://cassyni-user-files-prod.s3.amazonaws.com/6fLXuhW2edY5ZxYfPkzevJ https://cassyni.com/events/DRAA9biNuDiT4Ty7b71kmT?videoPreview=1 Developing AI-Enhanced Curriculanohttps://cassyni.com/events/DRAA9biNuDiT4Ty7b71kmT?videoPreview=12025-10-16T06:00:00+00:003390.28AAMCReady to reimagine curriculum design with AI? This session will guide you through using AI tools to create syllabi, learning objectives, and curriculum maps—while critically evaluating their effectiveness and ethical implications. Learn how to harness AI’s potential without compromising educational equity or fairness. Whether you're building a new course or refining an existing one, this session will give you the tools to innovate responsibly. Objectives: - Use AI tools to design curriculum components, including syllabi and learning objectives - Integrate AI-generated content into curriculum mapping - Evaluate the effectiveness of AI in curriculum development - Evaluate the impact of bias and automation on educational equity and fairness This webinar is part of the AI Skill Building for Medical Educators webinar series, hosted by the AAMC. For more information, see [the complete series webpage](https://www.aamc.org/learn-network/affinity-groups/group-educational-affairs/webinar-series-ai-skill-building-medical-educators).   CME Information - View the last page of the slide deck for complete instructions on earning CME credit for this recording - CME credit for this learning opportunity is organized by Michigan State University College of Human Medicine Office of Continuing Medical Education - You will be prompted to create an account to obtain credithttps://cassyni-user-files-prod.s3.amazonaws.com/6fLXuhW2edY5ZxYfPkzevJ https://cassyni.com/events/Whsvt9sdfc2LZ3C1M7aHx1/abstract https://cassyni-user-files-prod.s3.amazonaws.com/MuQq7rJdWw9iRTNQ3Wgj2N https://cassyni.com/events/KLbwLFJ3LPFGn3fadiTGk5/seminar/qa https://cassyni.com/slides/outline/KLbwLFJ3LPFGn3fadiTGk5 https://cassyni.com/events/KLbwLFJ3LPFGn3fadiTGk5/abstract https://cassyni-user-files-prod.s3.amazonaws.com/HLdPXsP8EipxU4AdrpfEkE https://cassyni.com/events/KLbwLFJ3LPFGn3fadiTGk5?videoPreview=1 Co-Creating Data with Communities to Understand the Socioecological Drivers of Health: Bright Spot and Community Asset Mappingnohttps://cassyni.com/events/KLbwLFJ3LPFGn3fadiTGk5?videoPreview=12026-03-05T21:00:00+00:003553.52Family MedicineLearning Objectives: - Describe the Bright Spot and Community Asset Mapping methodology and how multivariate socioecological modeling can identify communities that perform better or worse than predicted for key health outcomes. - Explain how co-creating data with community members changes the selection of outcomes, interpretation of findings, and identification of actionable solutions. - Recognize how strengths-based, community-engaged data systems (e.g., Va-Accountable Health Engagement and Action Dashboard, VA-AHEAD) can support translational science, clinical care improvement, public health, and policy action by linking local data, lived experience, and intervention design.https://cassyni-user-files-prod.s3.amazonaws.com/HLdPXsP8EipxU4AdrpfEkE https://cassyni.com/events/Xgp3VLUAJq68fiuPc51ztD/abstract https://cassyni-user-files-prod.s3.amazonaws.com/NB3v7kWTc3TBpbcKf2eL2a https://cassyni.com/slides/outline/EQ6GknJuYSnFB9gVr4TThf https://cassyni.com/events/EQ6GknJuYSnFB9gVr4TThf/abstract https://cassyni-user-files-prod.s3.amazonaws.com/UzSfv2NHyTN3W5Cdomw3ki https://cassyni.com/events/EQ6GknJuYSnFB9gVr4TThf?videoPreview=1 Adaptative and flexible manufacturingnohttps://cassyni.com/events/EQ6GknJuYSnFB9gVr4TThf?videoPreview=12026-05-06T11:00:00+00:003172.044D Health Tech Network+Adaptive and flexible manufacturing is becoming a key requirement for next‑generation manufacturing systems in healthcare, where responsiveness, precision, and safety are paramount. Work will be presented on how adaptive manufacturing strategies can support the design and production of 4D health technology, using robotic manufacturing. Once key issue is that traditional robotic systems have joints which suffer from tribological effects, such as friction, wear and backlash. This can be eliminated by incorporating flexure‑based complaint mechanisms as pseudo joints which offer intrinsic compliance, reduced wear, and improved sterility, making them particularly attractive for medical and assistive robotic applications. Preliminary results highlight how components can be manufactured at scale while maintaining tight tolerances and repeatability. Flexible manufacturing approaches enable rapid iteration and customisation of health technology, allowing systems to evolve over time in response to clinical, ergonomic, and regulatory requirements. Adaptive manufacturing also supports resilient supply chains and personalised healthcare technologies accelerating innovation at the intersection of engineering, robotics, and healthcare delivery.https://cassyni-user-files-prod.s3.amazonaws.com/UzSfv2NHyTN3W5Cdomw3ki https://cassyni.com/slides/outline/SFgPypMPUo14GrfA1A2Ctm https://cassyni.com/events/SFgPypMPUo14GrfA1A2Ctm/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Fh8Cksody6VNz5J2AAT7pa https://cassyni.com/events/SFgPypMPUo14GrfA1A2Ctm?videoPreview=1 SSP Innovation Showcase (Summer 2025)nohttps://cassyni.com/events/SFgPypMPUo14GrfA1A2Ctm?videoPreview=12025-07-24T06:00:00+00:003628.6SSP Society for Scholarly PublishingA free webinar highlighting new and exciting industry innovations. Speakers presented their solutions in brief presentations and took questions. Participating Companies: Consensus, DCL, Hum, Silverchair.https://cassyni-user-files-prod.s3.amazonaws.com/Fh8Cksody6VNz5J2AAT7pa https://cassyni.com/slides/outline/SkL12VzuvFZ7GdC3bbK1A5 https://cassyni.com/events/SkL12VzuvFZ7GdC3bbK1A5/abstract https://cassyni-user-files-prod.s3.amazonaws.com/GiQdhb8DjaMj8fCzHcCnWJ https://cassyni.com/events/SkL12VzuvFZ7GdC3bbK1A5?videoPreview=1 The Forecast for Solarnohttps://cassyni.com/events/SkL12VzuvFZ7GdC3bbK1A5?videoPreview=12022-02-16T06:00:00+00:003623.24 School of Public PolicyCurrently responsible for just 2% of net generation, the U.S. solar industry has grown slowly over the last decade but could see rapid growth in the coming years. This webinar examined obstacles and opportunities in the sector, relevant state and federal policies, and what new technologies could mean for the future of the industry.https://cassyni-user-files-prod.s3.amazonaws.com/GiQdhb8DjaMj8fCzHcCnWJ https://cassyni.com/slides/outline/5WT237BM3Zjo8sCsj36s1F https://cassyni.com/events/5WT237BM3Zjo8sCsj36s1F/abstract https://cassyni-user-files-prod.s3.amazonaws.com/WXPPTeA5pHxS4YvNQz3xq4 https://cassyni.com/events/5WT237BM3Zjo8sCsj36s1F?videoPreview=1 A research career focused on investigating how self-incompatibility works nohttps://cassyni.com/events/5WT237BM3Zjo8sCsj36s1F?videoPreview=12025-08-05T10:00:00+00:003797.12NoneVernonica (Noni) Franklin-Tong is emeritus Professor at the University of Birmingham. She was educated in Suffolk and then at the University of Birmingham. Most of her career has been based at Birmingham. She is recognized at an international level for her work on self-incompatibility, cell-cell signalling and programmed cell death. In 2021 she was elected a Fellow of the Royal Society.Noni is renowned for her studies on self-incompatibility (SI). She has devoted her career to investigating cellular mechanisms involved in the regulation of the cell-cell recognition system of SI in *Papaver rhoeas* (the Field Poppy). Sexual reproduction in higher plants involves pollination, involving specific interactions between pollen and pistil. A key mechanism to prevent inbreeding is self-incompatibility (SI), which is a controlled by a single, multi-allelic S-locus. Incompatible ("self") pollen is rejected, and compatible ("non-self") pollen is allowed to fertilize the plant. SI plays a decisive role in determining plant reproductive success by preventing inbreeding. Regulation of pollination has high importance in relation to its impact on food security.Noni initiated pioneering cell and molecular research of *Papaver* SI. Her development of an *in vitro* bioassay allowed investigation of the cell biology of SI for the first time. This outstanding model system enabled elucidation of mechanisms responsible for rejection of incompatible pollen. Her studies have uncovered an intricate intracellular signalling network and revolutionized our understanding of the signals, downstream targets and key cellular processes that regulate SI, revealing new phenomena critical to this process, culminating in programmed cell death. Her lab achieved the first functional trans-genera transfer of a SI system using the *Papaver* S-determinants. This has implications for translational work; longer-term this may aid the quest to make F1 hybrids in some crops more easily. Noni will talk about her research career over the years. This will be a story about her personal journey and as her career has spanned ~40 years, it will also provide a bit of a historical perspective, as when she started her PhD, plant molecular biology did not exist! Although she will touch on some of her research findings along the way, showing how the research developed, her focus will be on illustrating some of the challenges that ECRs and researchers face, in the context of her career. This will include examples of attempts to obtain funding and problems to get manuscripts published, as well as personal challenges.https://cassyni-user-files-prod.s3.amazonaws.com/WXPPTeA5pHxS4YvNQz3xq4 https://cassyni.com/events/4X9owjtJAedeU7Nsd4dYCM/abstract https://cassyni-user-files-prod.s3.amazonaws.com/DX2KEz1WpFvjoXXpTHyBoC https://cassyni.com/slides/outline/NoAnmfLbox3gdSRmV3fQBo https://cassyni.com/events/NoAnmfLbox3gdSRmV3fQBo/abstract https://cassyni-user-files-prod.s3.amazonaws.com/EHjJRkYXrvCxUvhaZWpiLe https://cassyni.com/events/NoAnmfLbox3gdSRmV3fQBo?videoPreview=1 A1 – Machine Learning Methods for Determining the Likelihood of Grant Proposal Successnohttps://cassyni.com/events/NoAnmfLbox3gdSRmV3fQBo?videoPreview=12026-04-20T09:15:00+00:003023.68Research Analytics SummitHighly research active universities need robust, modern methods to categorize and understand the volume of proposals being submitted to sponsors. Proposals often take months of peer review before receiving a funding decision—especially those submitted to federal funders like the Department of Health and Human Services (DHHS) or the National Science Foundation (NSF). Research administrators and leadership need actionable insights on these proposals prior to the funding decision in order to prioritize workflows and strategic investments. Using a case study at a Carnegie R1 institution, this session will examine machine – learning models that could be trained using institutional proposal data to inform downstream decision – making and prioritization tools for research leadership and regulatory offices at universities highly engaged with HHS to understand the likelihood of a proposal being funded. Limitations and bias reduction strategies will be discussed.https://cassyni-user-files-prod.s3.amazonaws.com/EHjJRkYXrvCxUvhaZWpiLe https://cassyni.com/slides/outline/HN39G9DpyuxcEaBXt8fcCM https://cassyni.com/events/HN39G9DpyuxcEaBXt8fcCM/abstract https://cassyni-user-files-prod.s3.amazonaws.com/3FuRGoAjHUV1PYJt2cw8hL https://cassyni.com/events/HN39G9DpyuxcEaBXt8fcCM?videoPreview=1 E3 – from Data to Strategy: A Competitive Intelligence Roadmap for Federal Research Fundingnohttps://cassyni.com/events/HN39G9DpyuxcEaBXt8fcCM?videoPreview=12026-04-20T14:45:00+00:003752.24Research Analytics SummitThis project presents a structured approach to competitive intelligence (CI) for research institutions, focusing on understanding and enhancing federal research funding profiles. The analysis begins with a comparative assessment of the funding landscapes across the mentor and mentee five states (Colorado, Pennsylvania, Texas, Utah, and Virgina), providing context for how geographic and policy differences influence institutional funding opportunities. Building on this, each mentee institution will map its own research funding profile using NCSES data, identifying trends in funding amounts, and areas of research focus. The next layer of analysis examines the key federal agencies supporting each institution, with a particular focus on NIH, NSF, and DoD, to identify primary funders and funding patterns. Also, by benchmarking these profiles against peer institutions, participants will gain insight into competitive positioning, discover gaps, and uncover opportunities for strategic growth. The session will provide a replicable roadmap for conducting CI in research, offering practical guidance on how to analyze funding data, identify peers, and develop strategies to enhance competitiveness across major federal agencies. Participants will leave equipped to leverage CI to inform research development, strategic planning, and proposal targeting for sustained institutional success.https://cassyni-user-files-prod.s3.amazonaws.com/3FuRGoAjHUV1PYJt2cw8hL https://cassyni.com/slides/outline/ViFFREPwxMoU8FRLrVELLV https://cassyni.com/events/ViFFREPwxMoU8FRLrVELLV/abstract https://cassyni-user-files-prod.s3.amazonaws.com/TntmbWz5ut1QHNBWmwnsBk https://cassyni.com/events/ViFFREPwxMoU8FRLrVELLV?videoPreview=1 F1 – Lessons Learned from Implementing AI Agents for Higher Education Research Compliancenohttps://cassyni.com/events/ViFFREPwxMoU8FRLrVELLV?videoPreview=12026-04-21T09:15:00+00:001881.92Research Analytics SummitResearch administrators need auditable access to Uniform Guidance, yet chatbot answers of unknown provenance may be outdated or non – citable, creating significant compliance and decision – making risk. To solve that problem we are developing a Model Context Protocol (MCP) server. MCP offers a consistent and transparent way to supply context from external sources to AI systems to deliver more reliable, up to date outputs. AI agents, when combined with MCP, can reduce manual searching, support consistent decision – making, and ensure that responses to policy questions are based on the most current federal requirements. Join data professionals from the University of Missouri and the University of Idaho for a practical overview of AI agents in higher education and lessons learned from implementing a locally hosted MCP server. By the end of the session, attendees will understand the basics of the AI agents, how federal policy text can be extracted from the electronic Code of Federal Regulations (eCFR), and the core components of building an MCP server. Participants will also gain practical insights into implementation considerations and access to example Python code via a public code repository. This session is ideal for research administrators, analytic engineers, data scientists, and anyone interested in utilizing AI agents in higher education. Basic usage of AI and knowledge of programming is recommended to maximize learning from this session.https://cassyni-user-files-prod.s3.amazonaws.com/TntmbWz5ut1QHNBWmwnsBk https://cassyni.com/slides/outline/33EcvKTcFdu2vQRiTv8fuw https://cassyni.com/events/33EcvKTcFdu2vQRiTv8fuw/abstract https://cassyni-user-files-prod.s3.amazonaws.com/V4ieVW3tsrHQrszNSUHEdL https://cassyni.com/events/33EcvKTcFdu2vQRiTv8fuw?videoPreview=1 Topological Plasmonicsnohttps://cassyni.com/events/33EcvKTcFdu2vQRiTv8fuw?videoPreview=12026-05-20T11:40:00+00:002666.88Connecting Science, Publishing, and InnovationWe utilize a new technique, time-resolved vector microscopy, that enables us to compose entire movies on a sub-femtosecond time scale and a 10 nm scale of the electric field vectors of surface plasmon polaritons. By using our vector microscopy technique, we are able to image the plasmonic spin-momentum-locking and the plasmonic skyrmion dynamics. Depending on the shape and geometrical phase, in combination with the helicity of the excitation beam, topological plasmonic quasiparticles are created: skyrmions, merons, as well as quasicrystalline excitations with 4D topology. We observe their entire field vector dynamics at subfemtosecond time resolution [1-6]. The figure on the right depicts a snapshot of the skyrmion electric field vector arrangement with sub-10 nm resolution on a single crystalline, atomically flat gold surface. When applying the concept of twistronics to plasmons, intriguing topological excitations arise, such as skyrmion bags. We find magic angles similar to twisted graphene which defines exceptional topological features. Utilizing topological plasmonics and twistronics will open the door to linear optical features on the few nm length scale [7], without the need for techniques such as STED. https://cassyni-user-files-prod.s3.amazonaws.com/V4ieVW3tsrHQrszNSUHEdL https://cassyni.com/slides/outline/9xK5ZtWxQ3epRDRHqMhc4d https://cassyni.com/events/9xK5ZtWxQ3epRDRHqMhc4d/abstract https://cassyni-user-files-prod.s3.amazonaws.com/9PM2x1NQS66WiKzQ4UQHga https://cassyni.com/events/9xK5ZtWxQ3epRDRHqMhc4d?videoPreview=1 Walking through a project on the Reflect! platformnohttps://cassyni.com/events/9xK5ZtWxQ3epRDRHqMhc4d?videoPreview=12019-09-05T06:00:00+00:001313.64 School of Public PolicyReflect! has been designed to organize reflective consensus building on wicked problems in small teams. The Reflect! Platform facilitated collaboration on wicked problems. Wicked problems are complex problems whose complexity results from the fact that they can be framed in a number of different ways, depending on who is looking at them. Stakeholders frame wicked problems differently depending on their interests, needs, values, worldviews, and background knowledge. Our ability to cope with wicked problems—and with the conflicts they usually create—is crucial for consensus building in the political and corporate world, and for any task that requires collaboration among people with different backgrounds. Reflect! could be used in problem-based learning projects (especially in ethics and social science education), by teams of professionals, and by stakeholders in controversies—both in face-to-face deliberation and online.https://cassyni-user-files-prod.s3.amazonaws.com/9PM2x1NQS66WiKzQ4UQHga https://cassyni.com/slides/outline/AwdumtKtgKghESwhDu7NW9 https://cassyni.com/events/AwdumtKtgKghESwhDu7NW9/abstract https://cassyni-user-files-prod.s3.amazonaws.com/LHYYvii5NVWWQ85hjHPp6r https://cassyni.com/events/AwdumtKtgKghESwhDu7NW9?videoPreview=1 Scientific Machine Learning in High Dimensions nohttps://cassyni.com/events/AwdumtKtgKghESwhDu7NW9?videoPreview=12026-06-25T12:30:00+00:003390.04MOX Laboratory - Department of MathematicsMany problems at the frontier of scientific machine learning reduce to solving high-dimensional partial differential equations: Hamilton–Jacobi– Bellman equations in optimal control, the continuity equation and Fokker–Planck equation in generative modeling, and coupled systems in mean-field games and Bayesian inverse problems, to give some examples. While the reach of classical numerical methods is limited by the curse of dimensionality, recent advances at the interface of numerical analysis and machine learning are beginning to change that picture by combining classical mathematical structure with neural-network approximation and Monte-Carlo-style sampling. In this talk I will discuss the mathematical and computational foundations of these methods with a focus on high-dimensional stochastic optimal control. I will draw on selected results from our group's work on neural HJB solvers, conditional optimal transport for Bayesian inference, and mean-field-games, and place them in the broader landscape of methods that have emerged in recent years. I will outline the main challenge of closing the gap between theoretical guarantees and practical performance. I will emphasize the role of sampling in determining whether neural methods discover the structure of high-dimensional value functions, the design of benchmarks, and the choice of discretization and adjoint formulations when differentiating through neural SDEs. I will close with open questions and opportunities for the scientific machine learning community.https://cassyni-user-files-prod.s3.amazonaws.com/LHYYvii5NVWWQ85hjHPp6r https://cassyni.com/events/619sK3reHk9Pn2f1ip416M/seminar/qa https://cassyni.com/slides/outline/619sK3reHk9Pn2f1ip416M https://cassyni.com/events/619sK3reHk9Pn2f1ip416M/abstract https://cassyni-user-files-prod.s3.amazonaws.com/SiShvnSmrF9QGsixiCeaox https://cassyni.com/events/619sK3reHk9Pn2f1ip416M?videoPreview=1 What’s producing the rabbit ears! Our 19-year quest to understand the weird electrical behaviour of carbon-filled elastomersnohttps://cassyni.com/events/619sK3reHk9Pn2f1ip416M?videoPreview=12026-05-12T04:00:00+00:003005.2The Auckland Bioengineering InstituteBack in 2007 Ben O’Brien, while a Part IV undergrad engineering student identified an interesting phenomenon associated with carbon-filled composite sensors that we now refer to as the "rabbit-ear effect". His experimental results were described in a humble 2007 SPIE conference paper that is still very much alive today (6 citations in 2026 alone!). If you measured resistance across the sensor while actively stretching it, the resistance would suddenly jump high and then settle back. Relaxing the sensor produced the same result. The plot could resemble a pair of rabbit ears. This has remained a mystery until several years ago when Logan Ritchie another PhD student in our lab studied the phenomenon and made a beautiful discovery about the world of carbon-filled composites and their electrical behaviour. We are close to explaining what is at the bottom of the rabbit ears (Not ‘Bugs Bunny’s head’ either!). https://cassyni-user-files-prod.s3.amazonaws.com/SiShvnSmrF9QGsixiCeaox https://cassyni.com/slides/outline/8UPtYU6GV2ut8y8aGVxdpH https://cassyni.com/events/8UPtYU6GV2ut8y8aGVxdpH/abstract https://cassyni-user-files-prod.s3.amazonaws.com/JWRnP6WK5qEz2Y5xCQVee https://cassyni.com/events/8UPtYU6GV2ut8y8aGVxdpH?videoPreview=1 Sponsor spotlight: Reliable and cost-effective library preparation with INTEGRA’s MAGFLO NGS beads for Illumina MiSeq amplicon sequencingnohttps://cassyni.com/events/8UPtYU6GV2ut8y8aGVxdpH?videoPreview=12026-05-12T12:59:00+00:0067.8Microbiome Virtual International ForumThe study shows the comparable performance of INTEGRA‘s MAGFLO™ NGS and AMPure XP magnetic beads when used in size selection for next generation sequencing (NGS) library preparation, followed by Illumina MiSeq amplicon sequencing. Amplicons of 16S rRNA and internal transcribed spacer (ITS) were obtained from a microbial mock culture standard containing genomic DNA from 8 bacterial species (3 Gram-negative and 5 Gram-positive) and 2 yeasts. We demonstrated no significant difference between the performance of MAGFLO™ NGS and AMPure XP magnetic beads during size selection steps in library preparation, or in consecutive sequencing results, with no sequencing bias in alpha diversity analysis of microbial compositionhttps://cassyni-user-files-prod.s3.amazonaws.com/JWRnP6WK5qEz2Y5xCQVee https://cassyni.com/slides/outline/3Xur5dd26TNrjsREG2Fe69 https://cassyni.com/events/3Xur5dd26TNrjsREG2Fe69/abstract https://cassyni-user-files-prod.s3.amazonaws.com/15okzXKZPhmcHqs8Ay7uiv https://cassyni.com/events/3Xur5dd26TNrjsREG2Fe69?videoPreview=1 The United States pension risk transfer marketand its implications for China's social insurance programnohttps://cassyni.com/events/3Xur5dd26TNrjsREG2Fe69?videoPreview=12026-04-23T01:00:00+00:001213.24Risk SciencesDr. Peixin Liu is a J. L. Doob research assistant professor in Actuarial Science and Risk Management at the Program of Actuarial Science and Risk Management, University of Illinois Urbana-Champaign. His research expertise is in theoretical asset pricing. Meanwhile I keep broad interests in multiple applicational research topics ranging from traditional problems in financial economics and asset pricing to newly emerging challenges faced by human community. This speech record is an excerpt from Dr.Liu 's keynote speech for the Risk Sciences Colloquium – [2025 International Workshop on Risk Sharing (IWRS)](https://www.keaipublishing.com/en/journals/risk-sciences/event/2025-international-workshop-on-risk-sharing-iwrs/) , which was held on July 6-7, 2025, in Beijing, China. [Risk sciences](https://www.keaipublishing.com/en/journals/risk-sciences/) aims to foster diverse, multidisciplinary insights in risk sciences, bridging theory and practice through a series of academic activities. https://cassyni-user-files-prod.s3.amazonaws.com/15okzXKZPhmcHqs8Ay7uiv https://cassyni.com/events/Ft7xEio94uDidYf3ENpNEH/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Rdkd45aUbyZXc5LGgrQemk https://cassyni.com/events/HrjzY5u8E6NCt3DWqkE5Wd/seminar/qa https://cassyni.com/slides/outline/HrjzY5u8E6NCt3DWqkE5Wd https://cassyni.com/events/HrjzY5u8E6NCt3DWqkE5Wd/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Fy2vLjQjMFT2ihTKdvB2tE https://cassyni.com/events/HrjzY5u8E6NCt3DWqkE5Wd?videoPreview=1 Talk session 2: Applications - Fluid Dynamics Inohttps://cassyni.com/events/HrjzY5u8E6NCt3DWqkE5Wd?videoPreview=12026-06-08T14:30:00+00:006535.96Nektar++ Development TeamThis session explored advanced computational fluid dynamics techniques and their applications across diverse engineering domains. One presentation focused on enhancing Newton's method for solving nonlinear problems, particularly in finding invariant solutions of the Navier-Stokes equations. Globalisation techniques, including inexact forcing, line search (backtracking), and trust-region methods leveraging GMRES, were discussed as modifications implemented within Nektar++ to improve robustness and efficiency, especially for geometric homotopy studies. A second talk demonstrated the application of high-order spectral element methods in Nektar++ for gas turbine simulations, highlighting improved shock resolution and boundary layer analysis compared to RANS models. This work detailed insights into high-pressure turbine and compressor blade flows, including the influence of pressure waves on transition and corner separation. The final presentation investigated turbulent wakes and F1 aerodynamics, first demonstrating the turbulent properties and Reynolds number insensitivity of a thin flat plate wake at Re=400 through high-fidelity DNS. Subsequently, it showcased the validation of implicit Large Eddy Simulation (LES) of an F1 front wing using novel Particle Tracking Velocimetry (PTV) experiments with LED illumination. This comparative study identified a previously unreported interaction vortex in the wake and revealed detailed agreements and discrepancies in vortex structures and ground-effect secondary vorticity.https://cassyni-user-files-prod.s3.amazonaws.com/Fy2vLjQjMFT2ihTKdvB2tE https://cassyni.com/events/6zUhX3faa2BGbZmG5C56m3/seminar/qa https://cassyni.com/slides/outline/6zUhX3faa2BGbZmG5C56m3 https://cassyni.com/events/6zUhX3faa2BGbZmG5C56m3/abstract https://cassyni-user-files-prod.s3.amazonaws.com/GQGptATunbpFzrE5pvkWjY https://cassyni.com/events/6zUhX3faa2BGbZmG5C56m3?videoPreview=1 Sustainable Materials for Electronics and Roboticsnohttps://cassyni.com/events/6zUhX3faa2BGbZmG5C56m3?videoPreview=12026-07-10T09:00:00+00:006913.4Advanced Electronic Materials JournalWe are pleased to invite you to join an upcoming webinar organized by the journal Advanced Electronic Materials with the title "Sustainable Materials for Electronics and Robotics" : with four speakers Dr. Pietro Cataldi (Universitas Mercatorum), Dr. Dimitrios Papageorgiou (Queen Mary University of London), Prof. Almudena Rivadeneyra (University of Granada) and Dr. Florian Hartman (Max Planck Institute for Intelligent Systems) the webinar is dedicated to the rapidly evolving field of biopolymers and sustainable materials for electronics and robotics. As electronic and robotic technologies become increasingly embedded in modern life, their environmental footprint—particularly in terms of waste—has emerged as a critical global challenge. This webinar will explore cutting-edge research and innovation to address this issue by developing biodegradable, biobased, and recyclable materials that can replace conventional components without compromising performance. Topics will span from fundamental material science to application-driven engineering solutions, highlighting opportunities for creating devices that align with circular economy principles. Join us to gain insight into how sustainable material innovation can enable the next generation of environmentally responsible electronic and robotic technologies. https://cassyni-user-files-prod.s3.amazonaws.com/GQGptATunbpFzrE5pvkWjY https://cassyni.com/events/ZM41XYojz6CChX2UH5Jmb/seminar/qa https://cassyni.com/slides/outline/ZM41XYojz6CChX2UH5Jmb https://cassyni.com/events/ZM41XYojz6CChX2UH5Jmb/abstract https://cassyni-user-files-prod.s3.amazonaws.com/UkzBJXEotPJH5zmaeU2JP8 https://cassyni.com/events/ZM41XYojz6CChX2UH5Jmb?videoPreview=1 Publishing with Impact: Insights from Wiley Advanced Editors - Part 2nohttps://cassyni.com/events/ZM41XYojz6CChX2UH5Jmb?videoPreview=12026-06-18T12:00:00+00:002037.52Advanced ScienceThe responsible integration of artificial intelligence (AI) tools and the upholding of research integrity are critical for scholarly publishing. A global study involving over 2,400 researchers reveals a significant increase in general AI tool use (from 57% to 84% in one year) and specific AI use for research and publishing tasks (from 45% to 62%). While AI enhances efficiency (85%), work quantity (77%), and quality (73%), concerns persist regarding inaccuracies (64%) and privacy (58%). Researchers overwhelmingly demand transparency, with nearly three-quarters requesting disclosure of AI use in the peer review process. Concurrently, a sharp rise in research misconduct is observed, with retracted papers doubling every 3.3 years and paper-mill products every 1.5 years. Suspicious patterns in submissions, content (e.g., data manipulation, plagiarism), and peer review are identified, often originating from paper mills, predatory publishers, and conferences. Publishers employ specialist software, including an AI-powered papermill detection service with six distinct tools, to combat these issues. Guidelines emphasize that AI tools should support, not replace, human judgment. Disclosure is required for AI use in methodology, substantial text generation, or image creation/editing. However, AI must not be used to create or alter original research data, mimic others' voices, or introduce bias, nor can AI be listed as an author. Confidentiality of unpublished manuscripts uploaded to AI tools is strictly prohibited. Safeguarding research integrity requires collective responsibility from authors, peer reviewers, editors, readers, and publishers.https://cassyni-user-files-prod.s3.amazonaws.com/UkzBJXEotPJH5zmaeU2JP8 https://cassyni.com/events/JMRDhQ4Y4ur2hWD2drM3gq/seminar/qa https://cassyni.com/slides/outline/JMRDhQ4Y4ur2hWD2drM3gq https://cassyni.com/events/JMRDhQ4Y4ur2hWD2drM3gq/abstract https://cassyni-user-files-prod.s3.amazonaws.com/KvHMXXyjrBVGtZnNMpwLna https://cassyni.com/events/JMRDhQ4Y4ur2hWD2drM3gq?videoPreview=1 Welcome and Introductionnohttps://cassyni.com/events/JMRDhQ4Y4ur2hWD2drM3gq?videoPreview=12026-06-17T09:30:00+00:001561.56Noneby: Dr Gustavo Quino Dr Carlos Fuenteshttps://cassyni-user-files-prod.s3.amazonaws.com/KvHMXXyjrBVGtZnNMpwLna https://cassyni.com/slides/outline/VDgWiSJ5iz2WDn34FPajdf https://cassyni.com/events/VDgWiSJ5iz2WDn34FPajdf/abstract https://cassyni-user-files-prod.s3.amazonaws.com/37jbAKGLPB1JvRKmE25Rwt https://cassyni.com/events/VDgWiSJ5iz2WDn34FPajdf?videoPreview=1 Why and how? Quantitative determination of plant programmed cell death induced by extreme heat.nohttps://cassyni.com/events/VDgWiSJ5iz2WDn34FPajdf?videoPreview=12026-06-03T08:00:00+00:002031.28As global temperatures surge beyond historical norms, plants increasingly face episodes exceeding 45°C, conditions that can trigger catastrophic cellular damage, tissue death, and ecosystem collapse. While research has defined the thermal limits of many plant species, the molecular and cellular determinants of survival versus death under extreme heat are not fully understood. Using tractable model systems, such as root hair assays and cell suspension cultures, we can quantify programmed cell death (PCD) in individual cells with high precision and dissect the transition from protective acclimation response to irreversible damage. These methods, informed by realistic heat application regimes and combined stress experiments, can open the door to integrative studies linking molecular signalling with whole-plant thermotolerance. In addition, we put forward the idea of adapting the concept of thermal performance curves to cellular systems as a novel, quantitative route to better connect cell-level stress physiology with organismal and ecological outcomes. Understanding how plant cells regulate their survival under extreme heat will not only inform strategies for enhancing crop resilience but also contribute to broader discussions on biological boundaries to life in a warming world.https://cassyni-user-files-prod.s3.amazonaws.com/37jbAKGLPB1JvRKmE25Rwt https://cassyni.com/events/51uuSwbNDYtc46HDKcHSDK/abstract https://cassyni-user-files-prod.s3.amazonaws.com/TqwYud4Rma31iKWjmgxxs8 https://cassyni.com/events/7V9vgMpzQqf6R2kmsJC4wF/seminar/qa https://cassyni.com/slides/outline/7V9vgMpzQqf6R2kmsJC4wF https://cassyni.com/events/7V9vgMpzQqf6R2kmsJC4wF/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Erim3Syrcu7WFaB3H14pvA https://cassyni.com/events/7V9vgMpzQqf6R2kmsJC4wF?videoPreview=1 From ultrasound to magnetic resonance imaging: Characterizing skeletal muscle structure and function in vivonohttps://cassyni.com/events/7V9vgMpzQqf6R2kmsJC4wF?videoPreview=12026-07-07T04:00:00+00:003630.32The Auckland Bioengineering InstituteSkeletal muscle is one of the most fascinating tissues of our body due to its capability to actively generate forces. Our current understanding of in vivo muscle behavior is largely based on observations from animal muscles, as direct muscle force measurements in humans are limited and highly invasive. Still, we know from decades of research that muscle structure is closely tied to its function, and this relationship manifests as length- and activity-dependent nonlinear behavior. The advancement of medical imaging techniques provides a great opportunity to characterize this behavior non-invasively, in vivo, at the whole muscle level. Ultrasound-based techniques such as shear wave elastography (SWE) and MRI-based techniques such as diffusion-tensor imaging each give unique insights; however, their use and interpretation of the derived measures are still challenging. This presentation will summarize my PhD research. I will explore what SWE experiments in passive and active muscle states can reveal, examine the current limitations to interpreting these data, and discuss how MRI-based models might help overcome these challenges in the future.https://cassyni-user-files-prod.s3.amazonaws.com/Erim3Syrcu7WFaB3H14pvA https://cassyni.com/events/EQEPKvtLZFQsuqkMEjm15w/abstract https://cassyni-user-files-prod.s3.amazonaws.com/E3tTAqHUxpS9oQqgQJqBGa https://cassyni.com/events/9TkLs6R6AfsrWk31EG41Mo/abstract https://cassyni-user-files-prod.s3.amazonaws.com/73BmsVSxQ9Xk13QWvCA97k https://cassyni.com/events/SFpWYxvpVbdh1Yj1PqKkH3/abstract https://cassyni-user-files-prod.s3.amazonaws.com/XGtPy1UFsGY6a3sWDHctKg https://cassyni.com/events/Bw1zD9AbmKa7hNyBycnozd/abstract https://cassyni-user-files-prod.s3.amazonaws.com/EVWo8sqgcMxFtY9rk4eena https://cassyni.com/events/NoJuLov2pkgKN8Vcsixwa5/abstract https://cassyni-user-files-prod.s3.amazonaws.com/VS6bRSPkW3LaVvV4KMhFmp https://cassyni.com/events/NoJuLov2pkgKN8Vcsixwa5?videoPreview=1 Tensor Decompositions and Low-rank Tensor Recoverynohttps://cassyni.com/events/NoJuLov2pkgKN8Vcsixwa5?videoPreview=12026-09-17T12:30:00+00:002844.04MOX Laboratory - Department of MathematicsTensor methods provide effective tools for representing, processing, analyzing, and recovering high-dimensional multiway data arising from imaging, sensing, communications, scientific computing, and machine learning applications. This talk reviews tensor decompositions and low-rank tensor recovery problems, together with applications and recent research directions. For tensor decompositions, we focus on their algebraic forms and characteristic properties. For low-rank tensor recovery, we introduce a generalized model that covers representative problems such as tensor completion and tensor robust principal component analysis. The corresponding methodologies are reviewed from three perspectives: low-rankness characterization, noise modeling, and structural priors for tensor data. We also summarize representative applications such as natural image and video restoration, hyperspectral image restoration, spatiotemporal traffic data imputation, and signal reconstruction.https://cassyni-user-files-prod.s3.amazonaws.com/VS6bRSPkW3LaVvV4KMhFmp https://cassyni.com/events/2Yj8SnPWpyycfKxgGA9R2u/seminar/qa https://cassyni.com/slides/outline/2Yj8SnPWpyycfKxgGA9R2u https://cassyni.com/events/2Yj8SnPWpyycfKxgGA9R2u/abstract https://cassyni-user-files-prod.s3.amazonaws.com/AuLTzQfax8GXamAGaYC3kJ https://cassyni.com/events/2Yj8SnPWpyycfKxgGA9R2u?videoPreview=1 Manual Therapies for Older Adults during the Decade of Healthy Ageing - Webinarnohttps://cassyni.com/events/2Yj8SnPWpyycfKxgGA9R2u?videoPreview=12026-09-02T11:00:00+00:008893.04Chiropractic & Manual Therapies This webinar will focus on the successful Special Issue in Chiropractic & Manual Therapies, titled 'Manual Therapies for Older Adults during the Decade of Healthy Ageing'. Authors from all 10 publications in the Special Issue will be joining, to present their research, discuss findings in detail, and answer your questions. Image credit: [Sincerely Media (Unsplash)](https://unsplash.com/photos/a-woman-holding-a-red-handle-while-standing-next-to-a-man-LYn0koTX-oo).https://cassyni-user-files-prod.s3.amazonaws.com/AuLTzQfax8GXamAGaYC3kJ https://cassyni.com/slides/outline/LqC56n5zv4DH9za9jPb1u7 https://cassyni.com/events/LqC56n5zv4DH9za9jPb1u7/abstract https://cassyni-user-files-prod.s3.amazonaws.com/LVS6j6LH9fkVwnbjBUNZQr https://cassyni.com/events/LqC56n5zv4DH9za9jPb1u7?videoPreview=1 FOS3D: A Fluorescence‐Enabled Toolkit for Characterizing a Three‐dimensional Osteosarcoma Modelnohttps://cassyni.com/events/LqC56n5zv4DH9za9jPb1u7?videoPreview=12026-09-03T21:00:00+00:001565.36Advanced OncologyOsteosarcoma (OS) is an aggressive primary bone malignancy for which therapeutic progress remains limited. Physiologically relevant three-dimensional (3D) models are needed to better investigate OS biology and treatment response, but their broader application is restricted by laborious workflows and destructive analytical methods. We developed FOS3D, a fluorescence-enabled 3D OS platform combining gelatin methacryloyl hydrogels with stable green fluorescent protein-expressing tumor cells. By modulating hydrogel composition and photo-crosslinking, we reproduced a range of stiffnesses representative of the OS stromal microenvironment. Whole-well fluorescence scanning enabled rapid, non-destructive longitudinal monitoring of tumor cell growth and treatment response, while light-sheet microscopy provided volumetric visualization of tumor organization within intact constructs. Molecular and histological analyses revealed microenvironment-driven changes associated with extracellular matrix remodeling, stemness, and drug resistance. Application of FOS3D to cisplatin and doxorubicin screening across two OS cell lines demonstrated dose-dependent responses and the enhanced treatment tolerance observed in 3D cultures. FOS3D therefore provides a scalable toolkit for investigating OS progression and evaluating therapeutic responses in physiologically relevant 3D environments.https://cassyni-user-files-prod.s3.amazonaws.com/LVS6j6LH9fkVwnbjBUNZQr https://cassyni.com/events/AxDzB79W8u8xJUa8DppemB/abstract https://cassyni-user-files-prod.s3.amazonaws.com/USA4LGXWiMRxbBFSPXtYnz https://cassyni.com/slides/outline/GNoBQ2xYuihYTKEPzKYfdf https://cassyni.com/events/GNoBQ2xYuihYTKEPzKYfdf/abstract https://cassyni-user-files-prod.s3.amazonaws.com/9zGHtkcyBe2ckotJKE8MT4 https://cassyni.com/events/GNoBQ2xYuihYTKEPzKYfdf?videoPreview=1 From Birds to Boroughs: Detection of Clade 2.3.4.4b Highly Pathogenic H5N1 Influenza Virus in NYCnohttps://cassyni.com/events/GNoBQ2xYuihYTKEPzKYfdf?videoPreview=12025-03-28T12:00:00+00:003440.04Journal of VirologyJoin Christine Marizzi, PhD, Phillip Meade, PhD, Kailani Gaynor, and Sadia Choudhury as they introduce the New York City Virus Hunters, a community science initiative that screens wild birds for infectious diseases—including avian influenza—that could impact wildlife and humans alike. Hear firsthand from program alumni about their experiences as youth researchers and discover how community scientists, veterinarians, and virologists are working together to generate real-world data and prepare for future pandemics. Learning Objectives: • Stay informed on emerging infectious disease in New York City’s migratory and resident wild birds.  • Learn about the power of community science, and how more representation, health literacy, and the ability to communicate scientific findings can enhance community trust and community engagement. • Become familiar with how to leverage media and journalism without getting misquoted. • Obtain insider tips on collaborating with youth in research.https://cassyni-user-files-prod.s3.amazonaws.com/9zGHtkcyBe2ckotJKE8MT4 https://cassyni.com/slides/outline/ZeuGTDZAxHBoxBScXQAiR https://cassyni.com/events/ZeuGTDZAxHBoxBScXQAiR/abstract https://cassyni-user-files-prod.s3.amazonaws.com/LZwjBpYDmCdtx9LJoWWLr2 https://cassyni.com/events/ZeuGTDZAxHBoxBScXQAiR?videoPreview=1 MetaMaps Workshop #1: Multimodal Mapping in the Artsnohttps://cassyni.com/events/ZeuGTDZAxHBoxBScXQAiR?videoPreview=12024-06-28T12:00:00+00:002160.44Hong Kong Baptist UniversityMBow was founded by Roberto Alonso Trillo and Peter Nelson to explore technological approaches to media art and performance. Nelson has produced exhibitions and new media experiences in Hong Kong since 2015, including interactive computer games for the K11 Art Foundation and Art Mall, VR films for Videotage, and solo projects for HanArt TZ Gallery. Trillo has been working as a sonic artist and performer in Hong Kong since 2019, including projects for Freespace at West Kowloon, the Hong Kong Museum of Arts, the Cultural Centre, or Hong Kong's City Hall. Nelson and Trillo have been producing exhibitions and performances together in Hong Kong since 2020, their major highlight being the 2022 Machine Visions exhibition and performance series with the Osage Art Foundation. As founding directors of MBow, Trillo and Nelson combine their expertise as technology designers and manufacturers with their combined three decades of experience as artists, musicians, and curators to present intellectually and physically immersive experiences that use art and technology to weave stories of our changing times for audiences in Hong Kong and beyond.https://cassyni-user-files-prod.s3.amazonaws.com/LZwjBpYDmCdtx9LJoWWLr2 https://cassyni.com/slides/outline/Dus1RYPg9Q83hdRFasxtrZ https://cassyni.com/events/Dus1RYPg9Q83hdRFasxtrZ/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Y2EBCRMTC1E2tJxkgj38qt https://cassyni.com/events/Dus1RYPg9Q83hdRFasxtrZ?videoPreview=1 JS2340 Bachelor of Fine Arts in Acting for Global Screennohttps://cassyni.com/events/Dus1RYPg9Q83hdRFasxtrZ?videoPreview=12021-06-03T12:00:00+00:002677.72Hong Kong Baptist UniversityThe programme director, Professor Michael Bray, is going to introduce a four-years undergraduate course, the Bachelor of Fine Arts in Acting for Global Screen, offered by our Academy of Film (電影學院) of the School of Communication at HKBU.https://cassyni-user-files-prod.s3.amazonaws.com/Y2EBCRMTC1E2tJxkgj38qt https://cassyni.com/events/8yNxxhvRkpb2JXhuaQFu8R/abstract https://cassyni-user-files-prod.s3.amazonaws.com/CpGiN1AFeZNSwcoX8X2LcW https://cassyni.com/events/8yNxxhvRkpb2JXhuaQFu8R?videoPreview=1 “Hallyu” (The Korean Wave) : Bloom and Reflectionnohttps://cassyni.com/events/8yNxxhvRkpb2JXhuaQFu8R?videoPreview=12022-12-09T12:00:00+00:002557.32Hong Kong Baptist University“Hallyu” (The Korean Wave）is the most popular and eye-catching cultural phenomenon in the world in past two decades. It has not only made Korea a “Cultural Power”, but also attracts scholars from different academic disciplines to study this special cultural phenomenon. This sharing session aims to briefly account for the rise and development of the “Hallyu”, and try to explore the reflections on this cultural phenomenon in recent years.https://cassyni-user-files-prod.s3.amazonaws.com/CpGiN1AFeZNSwcoX8X2LcW https://cassyni.com/slides/outline/BSczC8A3x7MWfUBU86AXrM https://cassyni.com/events/BSczC8A3x7MWfUBU86AXrM/abstract https://cassyni-user-files-prod.s3.amazonaws.com/HCmac2cCDBvgge47GW5fR8 https://cassyni.com/events/BSczC8A3x7MWfUBU86AXrM?videoPreview=1 Female identitiesnohttps://cassyni.com/events/BSczC8A3x7MWfUBU86AXrM?videoPreview=12020-06-27T12:00:00+00:00756.04Hong Kong Baptist UniversityNo abstracthttps://cassyni-user-files-prod.s3.amazonaws.com/HCmac2cCDBvgge47GW5fR8 https://cassyni.com/slides/outline/PnQkdmbst9JUMgPQr63JJ1 https://cassyni.com/events/PnQkdmbst9JUMgPQr63JJ1/abstract https://cassyni-user-files-prod.s3.amazonaws.com/QD5MeCKzQ4UcAWEmi1Qaw8 https://cassyni.com/events/PnQkdmbst9JUMgPQr63JJ1?videoPreview=1 Bangladesh’s Approach Towards Emerging Alliances in Asianohttps://cassyni.com/events/PnQkdmbst9JUMgPQr63JJ1?videoPreview=12023-02-14T12:00:00+00:009810.2Hong Kong Baptist UniversityNational security experts, academics, and international strategists gathered at the ‘Bangladesh's Approach towards Emerging Alliances in Asia’ seminar, organized by the Center for Peace Studies (CPS), North South University (NSU). They urged the Bangladesh government to identify the key areas of interest in order to achieve the country&#39;s economic and development goals within the developing Asian alliances. The participants noted that Asia is becoming the center of politics, economics, and culture, and that Bangladesh must overcome the challenges of being part of security alliances amid growing competition between global and regional powers.https://cassyni-user-files-prod.s3.amazonaws.com/QD5MeCKzQ4UcAWEmi1Qaw8 https://cassyni.com/slides/outline/JqviAw8dVZmSxag4qcLJZs https://cassyni.com/events/JqviAw8dVZmSxag4qcLJZs/abstract https://cassyni-user-files-prod.s3.amazonaws.com/6neLHYRXr8cnq2VvZ5Ezzi https://cassyni.com/events/JqviAw8dVZmSxag4qcLJZs?videoPreview=1 How to prove that God exists in less than 4 minutes (using the Cosmological Argument)nohttps://cassyni.com/events/JqviAw8dVZmSxag4qcLJZs?videoPreview=12024-01-28T12:00:00+00:008917.84Hong Kong Baptist UniversityIn this debate, atheist philosopher Dr. Daniel Linford and Christian philosopher Dr. Andrew Loke debate the topic: "In light of contemporary physics, we should not accept that the totality of physical reality had a cause or a beginning." Dr. Linford is taking the affirmative position and will go first.https://cassyni-user-files-prod.s3.amazonaws.com/6neLHYRXr8cnq2VvZ5Ezzi https://cassyni.com/events/UEFC3vRbqGHipL9CkjosSV/abstract https://cassyni-user-files-prod.s3.amazonaws.com/VrfgaDVkCDPYnFaFj6NnLe https://cassyni.com/events/UEFC3vRbqGHipL9CkjosSV?videoPreview=1 Hell & Universalism Part 1nohttps://cassyni.com/events/UEFC3vRbqGHipL9CkjosSV?videoPreview=12022-12-13T12:00:00+00:006307.2Hong Kong Baptist UniversityAbstract not yet added.https://cassyni-user-files-prod.s3.amazonaws.com/VrfgaDVkCDPYnFaFj6NnLe https://cassyni.com/slides/outline/42UanRitKq9peePMpxWa29 https://cassyni.com/events/42UanRitKq9peePMpxWa29/abstract https://cassyni-user-files-prod.s3.amazonaws.com/8ZLoWZym7vMWpqxJqeEabp https://cassyni.com/events/42UanRitKq9peePMpxWa29?videoPreview=1 Patrick Yim performs ‘Inside the Mind Of…’ by Austin Yipnohttps://cassyni.com/events/42UanRitKq9peePMpxWa29?videoPreview=12020-10-19T12:00:00+00:00165.96Hong Kong Baptist UniversityFor the 2020 MacDowell National Benefit on October 19, violinist Dr. Patrick Yim performed “Inside the Mind Of...,” an audiovisual violin piece from the chamber opera "Grandmother," by composer and MacDowell Fellow Austin Yip (19). The composition was one the works Austin drafted during his Fall 2019 MacDowell residency.https://cassyni-user-files-prod.s3.amazonaws.com/8ZLoWZym7vMWpqxJqeEabp https://cassyni.com/slides/outline/GP72exdJLgtY4Ztp8ZsXaV https://cassyni.com/events/GP72exdJLgtY4Ztp8ZsXaV/abstract https://cassyni-user-files-prod.s3.amazonaws.com/YP54imxWuGq9e1pmSZZrop https://cassyni.com/events/GP72exdJLgtY4Ztp8ZsXaV?videoPreview=1 Privacy Commissioner For Personal Datanohttps://cassyni.com/events/GP72exdJLgtY4Ztp8ZsXaV?videoPreview=12023-08-29T12:00:00+00:00379.72Hong Kong Baptist UniversityThe Personal Data (Privacy) Ordinance is overseen by the Privacy Commissioner for Personal Data, an independent body tasked with ensuring compliance. This abstract examines the High Court's decision in *EASTWEEK PUBLISHER LIMITED, EASTWEEK LIMITED V PRIVACY COMMISSIONER FOR PERSONAL DATA, CACV000331/1999*, which significantly clarified the scope of personal data protection. The case originated from a complaint filed in September 1997 by Ms. Maria Tam Nga Wai, whose photograph was secretly taken in a public street, published in Eastweek magazine on September 25, 1997, and accompanied by critical commentary. The Commissioner determined that Eastweek had unfairly collected personal data concerning the complainant, violating Data Protection Principle 1 subparagraph 2, which mandates fair data collection. Eastweek’s application for judicial review was dismissed, but its subsequent appeal was allowed. The High Court judgment distinguished between "personal privacy" and "information privacy." It held that for an item to constitute "personal data" under the Ordinance, it must be "an item of personal information attaching to the identified subject." Since the complainant was photographed as an anonymous subject to illustrate a fashion sense, and her identity was not known or needed for the article, the court concluded that the Ordinance did not apply. This ruling indicates that common journalistic practices involving photographs of unidentified individuals in public for illustrative purposes are not unduly constrained by the Ordinance, provided no specific information about an identified person is being compiled. Media entities remain subject to the Ordinance when collecting data about specific individuals.https://cassyni-user-files-prod.s3.amazonaws.com/YP54imxWuGq9e1pmSZZrop https://cassyni.com/slides/outline/JMH78FV747DPxp9BFB3WJZ https://cassyni.com/events/JMH78FV747DPxp9BFB3WJZ/abstract https://cassyni-user-files-prod.s3.amazonaws.com/N6y3dmbtgDBdoeiYrFisZp https://cassyni.com/events/JMH78FV747DPxp9BFB3WJZ?videoPreview=1 Introduction to R and R-Studio - Ep.42nohttps://cassyni.com/events/JMH78FV747DPxp9BFB3WJZ?videoPreview=12022-07-06T12:00:00+00:00231.0Hong Kong Baptist UniversityR and RStudio are presented as powerful tools for data analysis and visualization. R functions as a free software environment and programming language, while RStudio provides an integrated, user-friendly shell for working with R. The setup process involves installing R before RStudio. RStudio’s interface features a code editor, an R console, and panels for environment/history and files/plots/packages. The utility of these tools is demonstrated through a practical example involving the calculation of mean experimental scores for different subject groups (female and male). Experimental results, initially in an Excel file, are first converted to a CSV format for compatibility with R. The dataset is then imported into RStudio using the `read.csv()` function. Subsequent analysis involves applying the `aggregate()` function, specifically `aggregate(Score ~ Gender, data1, mean)`, to compute the mean scores for each gender group. This process successfully yields the distinct mean values, highlighting the effectiveness of R and RStudio in performing targeted data aggregation and statistical calculations.https://cassyni-user-files-prod.s3.amazonaws.com/N6y3dmbtgDBdoeiYrFisZp https://cassyni.com/slides/outline/VDYQ9HieiBPsV5yCriHCFP https://cassyni.com/events/VDYQ9HieiBPsV5yCriHCFP/abstract https://cassyni-user-files-prod.s3.amazonaws.com/3VbBLrrVfmGe66gVq8stSA https://cassyni.com/events/VDYQ9HieiBPsV5yCriHCFP?videoPreview=1 T05 Artificial Neural Networksnohttps://cassyni.com/events/VDYQ9HieiBPsV5yCriHCFP?videoPreview=12023-08-07T12:00:00+00:00518.48Hong Kong Baptist UniversityArtificial neural networks (ANNs) are supervised algorithms that emulate biological brain structures for data classification and prediction. The foundational perceptron, introduced in 1958, features input and output layers composed of interconnected neurons, where weighted links undergo adjustment during training to enable pattern recognition. Its evolution into multi-layer perceptrons (MLPs) in the 1980s, incorporating "hidden layers," marked the advent of deep learning. The network's topology, defined by the number of layers and neurons within them, is critical, with input and output layers corresponding to data size and target classes, respectively. An empirical investigation using the Orange workflow environment evaluated MLP performance for classifying the Titanic dataset. With "sex," "age," and "pclass" as features and a 70% data sampling rate, an MLP configured with 50 hidden neurons achieved a precision of 84.9%, exceeding that of decision trees (84.4%). The addition of the "Embarked" feature subsequently reduced precision to 84.6%. Increasing the hidden layer to 256 neurons restored precision to 84.9%. However, configuring the network with two hidden layers (256, 256) decreased precision to 84.4%, suggesting an overly complex model for the dataset. These findings underscore that determining the optimal ANN configuration is an iterative trial-and-error process, given the unexplainable nature of their internal decision mechanisms.https://cassyni-user-files-prod.s3.amazonaws.com/3VbBLrrVfmGe66gVq8stSA https://cassyni.com/slides/outline/Rm1ApWBydyXETPfeD3uEiZ https://cassyni.com/events/Rm1ApWBydyXETPfeD3uEiZ/abstract https://cassyni-user-files-prod.s3.amazonaws.com/UHEq2mZTw8Aq7PaPFLFFj4 https://cassyni.com/events/Rm1ApWBydyXETPfeD3uEiZ?videoPreview=1 The Intersection between Cantonese Opera and Hong Kong Cinemanohttps://cassyni.com/events/Rm1ApWBydyXETPfeD3uEiZ?videoPreview=12020-12-17T12:00:00+00:006365.08Hong Kong Baptist UniversityThe panel will explore the unique environment in Hong Kong and the aesthetics of Cantonese Opera which contributed to the evolution of Cantonese Opera on film and formed the basis of the world-renowned Hong Kong film industry. The expert scholars will also examine many influences that helped shape Cantonese Opera in Hong Kong film including the importance of women as the stories and music were being produced as entertainment for the masses. The historical remnants and influences of the period on contemporary Cantonese opera, film and performance art will also be explored.https://cassyni-user-files-prod.s3.amazonaws.com/UHEq2mZTw8Aq7PaPFLFFj4 https://cassyni.com/slides/outline/51mnso1wCkFyKQDMvvytq3 https://cassyni.com/events/51mnso1wCkFyKQDMvvytq3/abstract https://cassyni-user-files-prod.s3.amazonaws.com/8AbLcTfg7aQz7RcavVp4nA https://cassyni.com/events/51mnso1wCkFyKQDMvvytq3?videoPreview=1 Corpora and Translation Education: Advances and Challengesnohttps://cassyni.com/events/51mnso1wCkFyKQDMvvytq3?videoPreview=12024-03-26T12:00:00+00:004972.32Hong Kong Baptist UniversityThis edited volume explores advances and challenges in integrating corpora into translation education, emphasizing the need for translators to acquire both translation and technology literacies in the evolving language industry. Contributions survey the origins and state-of-the-art of corpus-based teaching methods, advocating for approaches that empower students as active participants in corpus design and utilization. One chapter investigates applying incremental learning to post-editing systems for online adaptation of automatic post-editing (APE) models. This experimental study, using neural networks and non-synthetic corpora, found that APE models struggled to achieve high performance and often over-corrected, indicating the difficulty of automating post-editing and the need for more stable models and real-time human-system interaction. Other contributions detail practical applications for teaching, including effective monolingual terminology extraction using tools like Sketch Engine, strategies for acquiring parallel texts from resources like OPUS to enrich translation memories, and methods for creating virtual corpora to analyze domain-specific vocabulary. Research on learner corpora highlights data acquisition challenges and presents findings from a corpus of Hong Kong tertiary students. Analysis revealed distortion of meaning as a frequent error in both English-to-Chinese and Chinese-to-English translations, alongside style errors in the former and tense errors in the latter. Overall, the volume underscores that corpora, when integrated with other methodological tools such as cognitive maps, can enhance trainees' cognitive processes, creativity, and understanding of specialized domains, ultimately helping them master complex concepts and face contemporary industry challenges. The ongoing discussion about the role of artificial intelligence in translation pedagogy is also addressed, stressing the importance of developing core translation skills and critical analysis in students.https://cassyni-user-files-prod.s3.amazonaws.com/8AbLcTfg7aQz7RcavVp4nA https://cassyni.com/slides/outline/7V1p7DFZQ32TgLgvUctXYy https://cassyni.com/events/7V1p7DFZQ32TgLgvUctXYy/abstract https://cassyni-user-files-prod.s3.amazonaws.com/TqixRGuPxbsMwQcbbwPuAv https://cassyni.com/events/7V1p7DFZQ32TgLgvUctXYy?videoPreview=1 Interpreting in Emergencies: Implications for Crisis Responsenohttps://cassyni.com/events/7V1p7DFZQ32TgLgvUctXYy?videoPreview=12023-12-04T12:00:00+00:002932.36Hong Kong Baptist UniversityAs disasters, public health crises, conflicts and climate change become increasingly prevalent worldwide, the importance of effective communication during emergencies has come to the fore. This growing area of research points to the increasingly crucial and complex role of interpreting in a globalised world where crises unfold across borders and language barriers. In this presentation, Marija Todorova reviews key findings and advances in interpreting for emergency management and relief efforts. Through a case study of Hong Kong's disaster response, she examines difficulties in utilizing interpreting to promote inclusion of affected populations across all phases of crisis mitigation.https://cassyni-user-files-prod.s3.amazonaws.com/TqixRGuPxbsMwQcbbwPuAv https://cassyni.com/slides/outline/TG88kzmmsW5zyciNX7rJQV https://cassyni.com/events/TG88kzmmsW5zyciNX7rJQV/abstract https://cassyni-user-files-prod.s3.amazonaws.com/YPST7op2rmgQYuwhjf351Y https://cassyni.com/events/TG88kzmmsW5zyciNX7rJQV?videoPreview=1 Adventures with Nanocrystalsnohttps://cassyni.com/events/TG88kzmmsW5zyciNX7rJQV?videoPreview=12021-10-27T23:15:00+00:002573.32The MacDiarmid Institute for Advanced Materials and NanotechnologyHi all - Due to some IP issues I wont be talking about my new upconversion data. Instead I will talk about 3 papers from my PhD on: Multiple Exciton Generation in PVs. Photon Reabsorption in LEDs. and a project we fondly referred as "Good Dot Bad Dot".https://cassyni-user-files-prod.s3.amazonaws.com/YPST7op2rmgQYuwhjf351Y https://cassyni.com/slides/outline/LM6vLgkCXpBm8WDtWrZ3Jm https://cassyni.com/events/LM6vLgkCXpBm8WDtWrZ3Jm/abstract https://cassyni-user-files-prod.s3.amazonaws.com/MnpDG4BJ4SKaJ7kEdKrnQE https://cassyni.com/events/LM6vLgkCXpBm8WDtWrZ3Jm?videoPreview=1 12 Labours Seminar Series (Exemplar Project 2): Personalised rehabilitation of upper limb disordersnohttps://cassyni.com/events/LM6vLgkCXpBm8WDtWrZ3Jm?videoPreview=12022-03-01T23:00:00+00:003825.56Auckland Bioengineering InstituteWe will present a new approach to personalised rehabilitation of musculoskeletal disorders, which incorporates quantitative assessment using wearable sensors and novel clinic-based tools together with biomechanical models and data-driven classification systems. Examples will be presented for the assessment of shoulder function and paediatric lower limb disorders. https://cassyni-user-files-prod.s3.amazonaws.com/MnpDG4BJ4SKaJ7kEdKrnQE https://cassyni.com/slides/outline/6Wx13YdWEzgHVKmBcBCdZw https://cassyni.com/events/6Wx13YdWEzgHVKmBcBCdZw/abstract https://cassyni-user-files-prod.s3.amazonaws.com/CbwT59QEd6eLqQEZXSHyZp https://cassyni.com/events/6Wx13YdWEzgHVKmBcBCdZw?videoPreview=1 Displacement convexity and mean-field gamesnohttps://cassyni.com/events/6Wx13YdWEzgHVKmBcBCdZw?videoPreview=12021-02-22T15:00:00+00:003075.56Partial Differential Equations and ApplicationsIn the theory of mean-field games (MFGs), a priori estimates play a crucial role to prove the existence of classical solutions. In particular, uniform bounds for the density of players' distribution and its inverse are of utmost importance. Here, inspired by previous results in the optimal transport theory, we investigate a priori bounds for a first-order planning problem with a non-vanishing potential and establish a displacement-convexity property. Using Moser's iteration method, we show that if the potential satisfies a certain smallness condition, then a displacement-convexity property holds. This property enables Lq bounds for the density. In the one-dimensional case, the displacement-convexity property also gives Lq bounds for the inverse of the density. Finally, using these Lq estimates and Moser's iteration method, we obtain L1 estimates for the density of the distribution of the players and its inverse. We conclude with an application of our estimates to prove the existence and uniqueness of solutions for a first-order mean-field planning problem.https://cassyni-user-files-prod.s3.amazonaws.com/CbwT59QEd6eLqQEZXSHyZp https://cassyni.com/slides/outline/JsBjKGKWcoT9aoGjMi4B2M https://cassyni.com/events/JsBjKGKWcoT9aoGjMi4B2M/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Js8o7fAaBcfcnURoTDQiyL https://cassyni.com/events/JsBjKGKWcoT9aoGjMi4B2M?videoPreview=1 Homogenization of resonant metafilmsnohttps://cassyni.com/events/JsBjKGKWcoT9aoGjMi4B2M?videoPreview=12021-03-23T14:00:00+00:005302.12MetaMATIn this talk, we will illustrate with three different examples the modeling of resonant metasurfaces using asymptotic homogenization techniques. We will first present the method on a periodic array of Helmholtz resonators (open cavities) in acoustics. In this case, the combination of bulk homogenization and interface homogenization allows to derive an approximated model in the time domain where the array of resonators is replaced by an anisotropic effective medium with effective jump conditions at boundaries. These conditions encapsulate all the evanescent contribution of the fields near the opening of the resonators and account for the transition between a quarter wavelength resonator to a Helmholtz resonator as the opening shrinks. In a second example we will focus on Mie resonance in elastodynamic for anti-plane shear waves. We will consider an array of sub-wavelength soft inclusions embedded in an elastic matrix. Due to the contrast of material properties between the constituents, the wavelength inside the soft inclusions become comparable to its size, hence leading to Mie resonances. We will show how asymptotic homogenization allows to capture the resonant behavior in an effective model consisting in frequency-dependent jump conditions across the array. Finally we will extend these results to a non-linear example in acoustic consisting in a screen of air bubbles inside water subjected to large pressure variations which is known to exhibit subwavelength Minnaert resonance. Homogenization theory applied to Navier-Stokes equations allows in this case to derive non-linear jump conditions where the behavior of the bubbles radii is governed by a non-linear equation of the Rayleigh-Plesset’s type.https://cassyni-user-files-prod.s3.amazonaws.com/Js8o7fAaBcfcnURoTDQiyL https://cassyni.com/slides/outline/JNY8GafzBLu6b2jqmGmNm3 https://cassyni.com/events/JNY8GafzBLu6b2jqmGmNm3/abstract https://cassyni-user-files-prod.s3.amazonaws.com/DaFmedrCiGti1sUKRJbNdc https://cassyni.com/events/JNY8GafzBLu6b2jqmGmNm3?videoPreview=1 BoltzTraP2nohttps://cassyni.com/events/JNY8GafzBLu6b2jqmGmNm3?videoPreview=12022-03-08T16:00:00+00:003250.52Computer Physics CommunicationsBoltzTraP2 is a software package for calculating a smoothed Fourier expression of periodic functions and the Onsager transport coefficients for extended systems using the linearized Boltzmann transport equation. It uses only the band and k-dependent quasi-particle energies, as well as the intra-band optical matrix elements and scattering rates, as input. The code can be used via a command-line interface and/or as a Python module. I will introduce the code and illustrate it through the discovery of a new thermoelectric material.https://cassyni-user-files-prod.s3.amazonaws.com/DaFmedrCiGti1sUKRJbNdc https://cassyni.com/slides/outline/VEoRHcuXqR5a7JZsNp14hs https://cassyni.com/events/VEoRHcuXqR5a7JZsNp14hs/abstract https://cassyni-user-files-prod.s3.amazonaws.com/DZ5gXRR2FrwkmxL3Dv553k https://cassyni.com/events/VEoRHcuXqR5a7JZsNp14hs?videoPreview=1 Black-hole waves at corners of a metallic particlenohttps://cassyni.com/events/VEoRHcuXqR5a7JZsNp14hs?videoPreview=12020-10-20T14:00:00+00:005320.08MetaMATIn this talk, we consider electromagnetic waves in presence of a metallic inclusion with corners, assuming that the dielectric permittivity has a very small imaginary part, that will be neglected, and a negative real part. Due to the sign-change of the dielectric permittivity, very unusual singular phenomena take place at corners. In particular, for some configurations, a part of the energy may be trapped by the corners: this is the so-called blackhole effect [1]. In this presentation, we first give a mathematical analysis of this blackhole phenomenon, based on a detailed description of the corner’s singularities, in the 2D case. This phenomenon leads to numerical instabilities of finite element simulations. The solution that we have found and validated is to introduce a complex scaling at the corners. Finally, we compute the plasmonic eigenvalues of a 2D subwavelength particle with a corner [2]. While a smooth particle has a discrete sequence of eigenvalues, blackhole waves at the corner lead to the presence of an essential spectrum filling an interval. Numerical results show that the complex scaling deforms this essential spectrum, so as to unveil both embedded eigenvalues and complex plasmonic resonances. The latter are analogous to well-known complex scattering resonances, with the local behaviour at the corner playing the role of the behaviour at infinity.https://cassyni-user-files-prod.s3.amazonaws.com/DZ5gXRR2FrwkmxL3Dv553k https://cassyni.com/events/43jbvkumT4qXGrz2M4ESUd/abstract https://cassyni-user-files-prod.s3.amazonaws.com/eXZBekbdGYHcyvnfaqoci https://cassyni.com/slides/outline/QJLzwQxArCTzoMybAHt8vh https://cassyni.com/events/QJLzwQxArCTzoMybAHt8vh/abstract https://cassyni-user-files-prod.s3.amazonaws.com/KmHSuq6AF6Kd2a1tGQSTVg https://cassyni.com/slides/outline/Hsru7GWaLXRGmZkKyAeQaq https://cassyni.com/events/Hsru7GWaLXRGmZkKyAeQaq/abstract https://cassyni-user-files-prod.s3.amazonaws.com/MB1CxCctWcdQXfN85JVPwU https://cassyni.com/events/Hsru7GWaLXRGmZkKyAeQaq?videoPreview=1 12 Labours Seminar Series: Overview of 12 Labours project and multiscale modellingnohttps://cassyni.com/events/Hsru7GWaLXRGmZkKyAeQaq?videoPreview=12021-11-02T23:00:00+00:003616.72Auckland Bioengineering InstituteThe ABI is leading the [International Physiome Project](https://www.iups.org/activities/physiome/) for the International Union of Physiological Sciences (IUPS) and it is a founding member of the Virtual Physiological Human (VPH) Institute [VPH Institute](https://www.vph-institute.org), an international non-profit organisation, whose mission is to ensure that the Virtual Physiological Human is fully realised, universally adopted, and effectively used both in research and clinic. The Physiome Project aims to establish a standards-based framework for multiscale computational physiology and has established the Physiome journal and associated portal in support of this aim. A five year project has recently been funded by the NZ Government’s Ministry of Business, Innovation and Employment (MBIE) to extend the Physiome Project infrastructure and to develop clinical workflows based around three ‘exemplar projects’ using three underpinning technology platforms as described below. The overall goal for the 12 Labours project is to further develop the predictive modelling capability that ABI and its international partners have built in the Physiome Project, and to add personalised modelling and various forms of wearable or implantable device to assist in the clinical diagnosis and treatment of a range of medical conditions. All software and models are open source and freely available as our contribution to open science but we are also looking for opportunities to create spinout companies that facilitate the clinical uptake of our science. As described below, we will use three exemplar projects (EPs) to demonstrate healthcare applications of multiscale biophysically based modelling, by combining multiscale models of multiple organ systems to address complex physiological questions. These three exemplars are: - *EP1: Pulmonary hypertension*: this exemplar will couple our previously independent research on the cardiovascular and respiratory systems to treat pulmonary hypertension. - *EP2: Personalised rehabilitation of upper limb disorders*: based on our neuro-musculoskeletal system work that is closely linked with the ICON project co-funded by the German Government. - *EP3: Control of organ function by the autonomic nervous system*: based on coupling our previously independent work on maternal health and the digestive system with our NIH-funded work on mapping the autonomic nervous system. The three technology platforms being developed are: - *Platform 1: A framework for personalised Physiome modelling*. We will develop the tools and databases needed to combine models, to link models across spatial and temporal scales, and to personalise the models ready to be used by the EPs in platforms 2 and 3. - *Platform 2: A Physiome modelling platform for precision medicine*. We will develop the workflows and databases needed to implement personalised Physiome models in a clinical setting. - *Platform 3: Continuous monitoring using Physiome workflows*. We will develop an interface between personalised Physiome models and wearable, implanted and home-based devices that can provide a continuous flow of data to update an individual’s personalised model for diagnostic monitoring and predicting therapeutic outcomes. Under 12 Labours, the multiscale models developed in the Physiome Project will be personalised for an individual with the tools developed in Platform 1, incorporated into clinical workflows in Platform 2, and interfaced to home-based healthcare devices in Platform 3.https://cassyni-user-files-prod.s3.amazonaws.com/MB1CxCctWcdQXfN85JVPwU https://cassyni.com/slides/outline/KMrxUaUvTcvyQGGF9pB9CZ https://cassyni.com/events/KMrxUaUvTcvyQGGF9pB9CZ/abstract https://cassyni-user-files-prod.s3.amazonaws.com/5EqsBVNEjMSiGpmVQy4wS6 https://cassyni.com/events/KMrxUaUvTcvyQGGF9pB9CZ?videoPreview=1 Imaging biological systems at the micron scalenohttps://cassyni.com/events/KMrxUaUvTcvyQGGF9pB9CZ?videoPreview=12022-04-05T04:00:00+00:002835.12The Auckland Bioengineering InstituteOur research group uses light to study biological processes with the aim of developing new diagnostic devices. We mainly focus on non-communicable diseases, food quality and food safety. We work mainly with 3 optical techniques: optical coherence tomography, fluorescence spectroscopy and nonlinear microscopy. During the talk, I will focus on a few projects and showcase some recent results.https://cassyni-user-files-prod.s3.amazonaws.com/5EqsBVNEjMSiGpmVQy4wS6 https://cassyni.com/slides/outline/SGwR89YGc2gku5FpXFk5MF https://cassyni.com/events/SGwR89YGc2gku5FpXFk5MF/abstract https://cassyni-user-files-prod.s3.amazonaws.com/S9MzuqDY7jiGbBxA27ojkA https://cassyni.com/events/SGwR89YGc2gku5FpXFk5MF?videoPreview=1 Bringing metamaterials to practice: influence of base material and novel applicationsnohttps://cassyni.com/events/SGwR89YGc2gku5FpXFk5MF?videoPreview=12022-04-19T13:00:00+00:006001.08MetaMATPhononic materials enable unprecedented control over acoustic waves in solids. In real structures, their expected functionalities can however be severely affected by the mechanics of base material. The first part of the talk discusses the influence of linear viscoelasticity on wave attenuation by polymer phononic materials. The accuracy of the mechanical models commonly used to model viscoelastic behavior of polymers is discussed and validated experimentally for conventionally and additively manufactured phononic structures. Next, two application prospects for metamaterials are proposed. These are metamaterial surface patterns for manipulating the aerodynamic and acoustic characteristics of artificial wings and kirigami metasheets as modular actuator arrays in adaptive optics.https://cassyni-user-files-prod.s3.amazonaws.com/S9MzuqDY7jiGbBxA27ojkA https://cassyni.com/slides/outline/Smb2AqBo3VEotqni7h2scZ https://cassyni.com/events/Smb2AqBo3VEotqni7h2scZ/abstract https://cassyni-user-files-prod.s3.amazonaws.com/J5CQAYWx88e1EDTEM9fpbY https://cassyni.com/events/Smb2AqBo3VEotqni7h2scZ?videoPreview=1 Mixed methodology approach for ergonomic and multiphysical characterisation of metamaterialsnohttps://cassyni.com/events/Smb2AqBo3VEotqni7h2scZ?videoPreview=12022-05-03T13:00:00+00:003619.56MetaMATMetamaterials have paved so far the way towards higher freedom of design of building’s features as their physical characteristics depend on the geometry rather than the constituent material. At this point, the research has reached an overall assessment of such innovative materials and applications are now arising within the engineering field. However, many building engineering applications have to address multiple physical constraints and mechanical responses while being tailored for ergonomic management by the final users. At this moment there is no clear indication of how these systems may interact with i) different environmental conditions and ii) different indoor and outdoor functions of the building. In this talk, I will first highlight our recent work to draw a new experimental method outlying the impact of metamaterials on the user’s perception through both ergonomics, psychoacoustics, and soundscape. In the second part of the presentation, I will introduce a new method in development to include different environmental conditions (in terms of temperature for example) to this ergonomic/human perception approach. Such methods could be used to make metamaterials more affordable from the engineers, designers, industries, and users’ point of view with a significant improvement in the industrial design applicability. https://cassyni-user-files-prod.s3.amazonaws.com/J5CQAYWx88e1EDTEM9fpbY https://cassyni.com/slides/outline/25AoreqZ6bYrjPVybUSmvu https://cassyni.com/events/25AoreqZ6bYrjPVybUSmvu/abstract https://cassyni-user-files-prod.s3.amazonaws.com/XtRBsDKQgRxWgmzndg7WNi https://cassyni.com/events/25AoreqZ6bYrjPVybUSmvu?videoPreview=1 Plant adaptation, domestication and invasion ecologynohttps://cassyni.com/events/25AoreqZ6bYrjPVybUSmvu?videoPreview=12022-05-12T14:00:00+00:003684.04New PhytologistHosted by New Phytologist Editor, [Andre Kessler, Cornell University](http://www.eeb.cornell.edu/kessler/index.html). Featuring - Anahí Fernandez, author of [Intentional and unintentional selection during plant domestication: herbivore damage, plant defensive traits and nutritional quality of fruit and seed crops](https://nph.onlinelibrary.wiley.com/doi/10.1111/nph.17452) - Ayub Oduor, author of [Native plant species show evolutionary responses to invasion by Parthenium hysterophorus in an African savanna](https://nph.onlinelibrary.wiley.com/doi/full/10.1111/nph.17574) https://cassyni-user-files-prod.s3.amazonaws.com/XtRBsDKQgRxWgmzndg7WNi https://cassyni.com/slides/outline/9UsFSH2YH6vvQGZpMgULS1 https://cassyni.com/events/9UsFSH2YH6vvQGZpMgULS1/abstract https://cassyni-user-files-prod.s3.amazonaws.com/6tB1dDFoa4S2BNzgHWW2yt https://cassyni.com/events/9UsFSH2YH6vvQGZpMgULS1?videoPreview=1 Tell me how to talk: Using meta pragmatics as a tool for understanding workplace interactionnohttps://cassyni.com/events/9UsFSH2YH6vvQGZpMgULS1?videoPreview=12022-06-10T04:00:00+00:003068.16Linguistics and Applied Language StudiesWhile local sociocultural norms (“ways of doing things round here”) are sometimes made explicit, our analysis of workplace interaction indicates that professional values and rules for appropriate behaviour often remain very subtle and inexplicit. Increasingly researchers are turning to metapragmatics for information about the ideas that interactants orient to when evaluating the behaviour of their interlocutors. While there is no direct link between stated ideologies and practices, investigations of talk about social meaning provide access to circulating Discourses. Using examples from our corpus we will explore metapragmatics in action. Importantly we seek successful examples of defending your position (especially as an outsider) and challenging the assumptions of others.https://cassyni-user-files-prod.s3.amazonaws.com/6tB1dDFoa4S2BNzgHWW2yt https://cassyni.com/slides/outline/HPJAQUQi79eJrnnCQEPUeq https://cassyni.com/events/HPJAQUQi79eJrnnCQEPUeq/abstract https://cassyni-user-files-prod.s3.amazonaws.com/9jUcbrmDUsXvbMcTUPUqVG https://cassyni.com/events/HPJAQUQi79eJrnnCQEPUeq?videoPreview=1 A Memo on Multiplicitynohttps://cassyni.com/events/HPJAQUQi79eJrnnCQEPUeq?videoPreview=12021-02-27T18:00:00+00:001198.04Mathematical IntelligencerNo abstracthttps://cassyni-user-files-prod.s3.amazonaws.com/9jUcbrmDUsXvbMcTUPUqVG https://cassyni.com/slides/outline/FQg877JiwxVpcboZkhb6bf https://cassyni.com/events/FQg877JiwxVpcboZkhb6bf/abstract https://cassyni-user-files-prod.s3.amazonaws.com/LMAZk7k4ki3jPyRj3SN71p https://cassyni.com/events/FQg877JiwxVpcboZkhb6bf?videoPreview=1 Mathematical Perspectives on Liar Paradoxesnohttps://cassyni.com/events/FQg877JiwxVpcboZkhb6bf?videoPreview=12021-09-15T10:40:00+00:004208.48Logica UniversalisThe liar paradox is a famous and ancient paradox related to logic and philosophy. It shows it is perfectly possible to construct sentences that are correct grammatically and semantically but that cannot be true or false in the traditional sense. In this paper the authors show four approaches to interpreting paradoxes that illustrate the influence of: (a) the levels of language, (b) their belonging to indeterminate compatible propositions (ICP) or indeterminate propositions (IP), (c) being based on universal antinomy and (d) the theory of dialetheism.https://cassyni-user-files-prod.s3.amazonaws.com/LMAZk7k4ki3jPyRj3SN71p https://cassyni.com/events/Bx8tnKn3skdBauW173D94q/abstract https://cassyni-user-files-prod.s3.amazonaws.com/BPaaDaSnHDsNaBGhAPbmae https://cassyni.com/slides/outline/NKnCsJsxVjBLFtVYQi6UNy https://cassyni.com/events/NKnCsJsxVjBLFtVYQi6UNy/abstract https://cassyni-user-files-prod.s3.amazonaws.com/TjzToxa1u1sZM4iXknkMVG https://cassyni.com/events/NKnCsJsxVjBLFtVYQi6UNy?videoPreview=1 Direct C-H-sulfonylation of pyridine and related 6-membered N-heteroaromaticsnohttps://cassyni.com/events/NKnCsJsxVjBLFtVYQi6UNy?videoPreview=12022-07-25T13:00:00+00:003047.84Tetrahedron Chem and Tetrahedron Green ChemHeteroaromatic sulfones and sulfonamides constitute important scaffolds in medicinal chemistry and the development of new drugs. Herein we describe a straightforward approach for the direct installation of sulfonyl functionalities onto 6-ring N-heteroaromatics via the direct functionalization of C-H-bonds. This novel method is based on preactivation of the N-heterocycle with trifle anhydride, followed by a base-mediated addition of sulfinate nucleophile and a subsequent elimination-rearomatization. Using this straightforward process, various N-heteroaromatics could be converted directly into the desired sulfonylated products in moderate to high yields. By exploiting either sulfur dioxide or the sulfur dioxide surrogates DABSO and rongacyl, this methodology could be extended to a modular construction of the key sulfonyl functionality. Furthermore, application of this protocol to the late-stage diversification of drug-like scaffolds and natural products is demonstrated. Further studies towards a base-mediated regioselective C4-sulfonylation of pyridines are described as well. In summary, our methods enable a a straightforward synthesis of biologically relevant sulfonylated N-heterocycles, an important motif in drug development. https://cassyni-user-files-prod.s3.amazonaws.com/TjzToxa1u1sZM4iXknkMVG https://cassyni.com/slides/outline/Qo2E6j7ah1x9MNJfN7FD4q https://cassyni.com/events/Qo2E6j7ah1x9MNJfN7FD4q/abstract https://cassyni-user-files-prod.s3.amazonaws.com/4aQP538xVQePFb6CvdxayL https://cassyni.com/events/Qo2E6j7ah1x9MNJfN7FD4q?videoPreview=1 Writing and Reading for/in Publicnohttps://cassyni.com/events/Qo2E6j7ah1x9MNJfN7FD4q?videoPreview=12022-05-11T04:30:00+00:003502.48Stout Research Centre for New Zealand StudiesMany academics are also public commentators, blog post authors and regular guests on radio. Lydia was a prolific public intellectual, writing countless book reviews for public outlets, talking on the radio about books and reading, and participating in our major writer and readers festivals.https://cassyni-user-files-prod.s3.amazonaws.com/4aQP538xVQePFb6CvdxayL https://cassyni.com/slides/outline/4YQq655BHtKM6KyY9AMQeq https://cassyni.com/events/4YQq655BHtKM6KyY9AMQeq/abstract https://cassyni-user-files-prod.s3.amazonaws.com/7sUDiaYrSyYAr8pgPUyMnn https://cassyni.com/events/4YQq655BHtKM6KyY9AMQeq?videoPreview=1 The vocabulary of the 1pm COVID-19 briefings: Implications for research, teaching and government communicationsnohttps://cassyni.com/events/4YQq655BHtKM6KyY9AMQeq?videoPreview=12022-08-12T04:00:00+00:003264.48Linguistics and Applied Language StudiesIn this talk, we report on a corpus-based study of vocabulary in the 1pm COVID-19 briefings in two ways across time (2020 and 2021) and between speakers (Prime Minister Jacinda Ardern and Director General of Health Dr Ashley Bloomfield). The first analysis focuses on the characteristics of the words in the corpus (e.g. risk, staggered, pandemic, motu and doffing) and vocabulary load of the corpus. The second reports briefly on single and multiword technical vocabulary (e.g. self-isolation, bubbles and MIQ) and highlights some complexities in undertaking such a study. Implications for teaching and government communications will be discussed.https://cassyni-user-files-prod.s3.amazonaws.com/7sUDiaYrSyYAr8pgPUyMnn https://cassyni.com/events/TGGFL9MCtJidiJnDuo9qnm/seminar/qa https://cassyni.com/slides/outline/TGGFL9MCtJidiJnDuo9qnm https://cassyni.com/events/TGGFL9MCtJidiJnDuo9qnm/abstract https://cassyni-user-files-prod.s3.amazonaws.com/AB8bnVziUCU5BKoHAXBJ1k https://cassyni.com/events/TGGFL9MCtJidiJnDuo9qnm?videoPreview=1 Next-generation HPC models for future rotorcraft applicationsnohttps://cassyni.com/events/TGGFL9MCtJidiJnDuo9qnm?videoPreview=12022-10-20T14:00:00+00:004309.92PyFRRotorcraft technologies pose great scientific and industrial challenges for numerical computing. As available computational resources approach the exascale, shifting legacy workflows and optimizing parallel efficiency and scalability of existing software on new hardware is often demanding. This is the case for the Leonardo Company, whose cutting-edge davinci-1 high-performance computing (HPC) cluster, powered by NVIDIA A100 GPUs, is currently being tested in order to be made available for engineering working groups. This talk will report preliminary results in CFD simulations using the T106A Low Pressure Turbine blade geometry on the HPC facility. Time to solution and weak and strong scalability on davinci-1’s GPU nodes are assessed for PyFR as well as commercial packages Ansys Fluent® and STAR-CCM+®. The results provide a first assessment of the potential of HPC architectures in scaling engineering applications towards certification by simulation, and the first step for the Company towards the use of innovative HPC toolkits in the field of Rotorcraft technologies.https://cassyni-user-files-prod.s3.amazonaws.com/AB8bnVziUCU5BKoHAXBJ1k https://cassyni.com/slides/outline/7zygXV7jmT7kwijizVZY6Z https://cassyni.com/events/7zygXV7jmT7kwijizVZY6Z/abstract https://cassyni-user-files-prod.s3.amazonaws.com/4HxGEAseJjTsBajdXK8RZ8 https://cassyni.com/events/7zygXV7jmT7kwijizVZY6Z?videoPreview=1 Rate determining term of electrocatalytic reactionsnohttps://cassyni.com/events/7zygXV7jmT7kwijizVZY6Z?videoPreview=12022-10-11T12:00:00+00:003799.24Electrochimica ActaThe quest to find highly active electrocatalysts for electrochemical energy conversion devices requires mechanistic concepts to guide activity analysis, the most commonly employed ones being the rate-determining step (RDS) and the potential-determining step (PDS). Here we present a generalized concept, the rate-determining term (RDT). The RDT concept is not simply a semantic change but a nontrivial improvement over the RDS and PDS concepts, as it incorporates the detailed kinetics and thermodynamics of multistep electrocatalytic reactions. The theoretical basis of the RDT concept is steady-state microkinetic modelling, for which we put forward a unified and compact formalism for electrocatalytic reactions with first-order kinetics. The new formalism allows us to write the expression for the rate determining term of the reaction in general and analytical form. The RDT concept is then used to derive analytical expressions for the Tafel slope and the volcano plot of activity that can be used in the studies of multistep electrocatalytic reactions. Thereafter, the efficacy of the RDT concept is demonstrated for two important case studies, the oxygen evolution reaction and the carbon dioxide reduction reaction. Fundamental insights into the origins of the potential-dependent Tafel slope are obtained. An important consequence, gleaned from this analysis, is that one cannot infer a RDS from measured Tafel slopes. In addition, kinetic factors are shown to exert a notable influence on the slopes and apex location in volcano plots of activity. The present RDT is anticipated to be a powerful analytical tool for multistep electrocatalytic reactions with first-order kinetics.https://cassyni-user-files-prod.s3.amazonaws.com/4HxGEAseJjTsBajdXK8RZ8 https://cassyni.com/slides/outline/Jsc52i3ofDM3mxikeE8oVf https://cassyni.com/events/Jsc52i3ofDM3mxikeE8oVf/abstract https://cassyni-user-files-prod.s3.amazonaws.com/WzZYS3Cc7sYopQ2uj7tsVg https://cassyni.com/events/Jsc52i3ofDM3mxikeE8oVf?videoPreview=1 HYPIC: A fast hybrid EM PIC-MCC code for ion cyclotron resonance energization in cylindrical coordinate systemnohttps://cassyni.com/events/Jsc52i3ofDM3mxikeE8oVf?videoPreview=12024-10-08T12:00:00+00:00436.84Computer Physics CommunicationsIon cyclotron resonance energization (ICRE) such as ion cyclotron resonance heating (ICRH) is widely applied to magnetic confinement fusion and high-power electric propulsion. Since ICRE involves cyclotron resonance processes, a kinetic model is required. Both conventional particle-in-cell (PIC) simulations and solving the Boltzmann equation require enormous computation and memory. The hybrid simulation incorporating of adiabatic electrons and PIC ions provides a viable solution for both a substantial reduction in computation and the inclusion of cyclotron resonance effects. Under the adiabatic electron approximation, we have developed a two-dimensional (r,z) hybrid electromagnetic (EM) PIC-MCC (Monte-Carlo collision) simulation program, named HYPIC. The advantages of HYPIC are the inclusion of ion kinetic effects, electrostatic (ES) and EM effects, and collisional effects of ions and electrons, with a small computation. The HYPIC program is able to fast simulate the antenna-plasma interactions and the ion cyclotron resonance energization and/or ion cyclotron resonance heating processes in linear devices, such as high-power electric propulsion, magnetic mirror, and field-reversed-configuration (FRC), etc. We also introduced the latest upgrades in HYPIC v1.1.https://cassyni-user-files-prod.s3.amazonaws.com/WzZYS3Cc7sYopQ2uj7tsVg https://cassyni.com/events/7WhAxzAjZgc4VijcHEh2Um/seminar/qa https://cassyni.com/slides/outline/7WhAxzAjZgc4VijcHEh2Um https://cassyni.com/events/7WhAxzAjZgc4VijcHEh2Um/abstract https://cassyni-user-files-prod.s3.amazonaws.com/H34eJ2DkNUQfo7XyKk6b5x https://cassyni.com/events/7WhAxzAjZgc4VijcHEh2Um?videoPreview=1 Flow Chemistrynohttps://cassyni.com/events/7WhAxzAjZgc4VijcHEh2Um?videoPreview=12024-12-11T14:00:00+00:003472.2Thieme GroupFlow chemistry provides unique advantages in organic synthesis, including allowing for greener or more atom-efficient routes, safer reaction setups, or enhanced product scaling. This [SynOpen](https://www.thieme.de/de/synopen/journal-information-102839.htm) Cheminar will explore a variety of topics in synthetic flow chemistry, with great speakers from institutes around the world.https://cassyni-user-files-prod.s3.amazonaws.com/H34eJ2DkNUQfo7XyKk6b5x https://cassyni.com/slides/outline/5Y8Ntt6XDDKPxFFZXeuMw3 https://cassyni.com/events/5Y8Ntt6XDDKPxFFZXeuMw3/abstract https://cassyni-user-files-prod.s3.amazonaws.com/TvBR4cjDX6rPLu3CwS78jY https://cassyni.com/events/5Y8Ntt6XDDKPxFFZXeuMw3?videoPreview=1 Pioneering hybrid heat recovery systems: Thermoelectric generators as insulators and channels boosted by vortex generatorsnohttps://cassyni.com/events/5Y8Ntt6XDDKPxFFZXeuMw3?videoPreview=12025-01-09T12:00:00+00:00740.08International Journal of ThermofluidsVortex generators are very effective tools in increasing heat transfer from one region to another, especially by convection, and appear to be a very promising concept to be coupled with heat recovery systems. On the other hand, Thermoelectric Generators (TEGs) are devices able to convert differences in temperature into electrical power using the Seebeck effect, the main advantage being working on high or even low differences in temperature. These TEG modules could be very effective tools in the hybridization of heat recovery systems. In this context, the present paper suggests an innovative system that couples three important energy axes together such as Heat recovery, TEGs, and Vortex generators. The current study employs a TEG in a rectangular channel to analyze the influence of the TEG on the flow and the effect of the effect of flow regime on producing electric power in order to assess the viability of this recently proposed concept. The investigation is conducted by varying the Reynolds number in a range of five values: 1000, 2000, 4000, 7000, and 10,000, applying six different configurations. Consequently, the results show that several factors affect the electrical power generated by TEG such as the emplacement, angle of attack, and absence/presence of vortex generators. On the other side, the heat recovered by the flow is affected by the TEG and Re, where the highest heat recovery is achieved at Re = 10,000 for configuration 4 with electrical power of 7.4 W, and for configuration 5 heat recovered by the flow of 1913 W. Besides, it was concluded that TEGs decreased the losses in both hot and cold sides by 1.42 times.https://cassyni-user-files-prod.s3.amazonaws.com/TvBR4cjDX6rPLu3CwS78jY https://cassyni.com/events/4YqAoWoULJDFHVRZRgS389/abstract https://cassyni-user-files-prod.s3.amazonaws.com/488usX5JcGC2Q7eLsstRjc https://cassyni.com/slides/outline/WEbqSKUXxprtm6TYTD9oSV https://cassyni.com/events/WEbqSKUXxprtm6TYTD9oSV/abstract https://cassyni-user-files-prod.s3.amazonaws.com/5dqKSxQHgxdNpvPRF9Wfa6 https://cassyni.com/events/WEbqSKUXxprtm6TYTD9oSV?videoPreview=1 Assessment of Health Insurance’s Role in Reducing Financial Barriers to Health Service Access: Perspective from a Resource Limited Settingnohttps://cassyni.com/events/WEbqSKUXxprtm6TYTD9oSV?videoPreview=12025-04-12T12:00:00+00:00781.96Sage PublishingBackground: In Ethiopia, Community-Based Health Insurance (CBHI) schemes aim to enhance healthcare accessibility and reduce financial barriers to health care access by provide protection against out-of-pocket (OOP) expenses. However, evidence on the institutional experience of insured patients remains limited. This study explores the financial implications of CBHI membership among inpatients at St. Paul’s Hospital Millennium Medical College. Methods: A cross-sectional study was conducted in the St. Paul’s Hospital Millennium Medical College Inpatient Department. After stratifying across different wards, the study participants were chosen by systematic random sampling. Data on socio-demographics and payment related factors were collected with a structured questionnaire. Ethical approval and informed consent were obtained. Results: 260 respondents, of whom 168 (64.6%) were CBHI members and 92 (35.4%) were non-members, had participated in the study. The result reveals that both CBHI members and non-members continue to bear OOP expenses, undermining the financial protection intended by the scheme. Among CBHI members, self-sponsored out-of-pocket payments along with health insurance (65, 38.7%) were the major source of financing. The significant reduction in reported difficulty in paying for basic necessities among CBHI members compared to non-members (p=0.034) does suggest that the insurance offers some level of financial relief. Conclusion: While CBHI provides some financial relief, gaps in coverage need more in-depth exploration. Keywords: Health Insurance, healthcare access, health financing, health policy outcomes, financial barriers.https://cassyni-user-files-prod.s3.amazonaws.com/5dqKSxQHgxdNpvPRF9Wfa6 https://cassyni.com/events/RJ7nyV1HaFKsMzkCSjSoiM/abstract https://cassyni-user-files-prod.s3.amazonaws.com/VA6FCYnct8zTfaK6tbdqG https://cassyni.com/slides/outline/9xcvppBhq1qp2mfYwSdoEd https://cassyni.com/events/9xcvppBhq1qp2mfYwSdoEd/abstract https://cassyni-user-files-prod.s3.amazonaws.com/7FsDLjPsyZQZoT99Tn4cd4 https://cassyni.com/events/9xcvppBhq1qp2mfYwSdoEd?videoPreview=1 Healthy microbiome—moving towards functional interpretationnohttps://cassyni.com/events/9xcvppBhq1qp2mfYwSdoEd?videoPreview=12025-11-12T15:00:00+00:00605.2Microbiome Virtual International Forum"Background Microbiome-based disease prediction has significant potential as an early, noninvasive marker of multiple health conditions linked to dysbiosis of the human gut microbiota, thanks in part to decreasing sequencing and analysis costs. Microbiome health indices and other computational tools currently proposed in the field often are based on a microbiome’s species richness and are completely reliant on taxonomic classification. A resurgent interest in a metabolism-centric, ecological approach has led to an increased understanding of microbiome metabolic and phenotypic complexity, revealing substantial restrictions of taxonomy-reliant approaches. Findings In this study, we introduce a new metagenomic health index developed as an answer to recent developments in microbiome definitions, in an effort to distinguish between healthy and unhealthy microbiomes, here in focus, inflammatory bowel disease (IBD). The novelty of our approach is a shift from a traditional Linnean phylogenetic classification toward a more holistic consideration of the metabolic functional potential underlining ecological interactions between species. Based on well-explored data cohorts, we compare our method and its performance with the most comprehensive indices to date, the taxonomy-based Gut Microbiome Health Index (GMHI), and the high-dimensional principal component analysis (hiPCA) methods, as well as to the standard taxon- and function-based Shannon entropy scoring. After demonstrating better performance on the initially targeted IBD cohorts, in comparison with other methods, we retrain our index on an additional 27 datasets obtained from different clinical conditions and validate our index's ability to distinguish between healthy and disease states using a variety of complementary benchmarking approaches. Finally, we demonstrate its superiority over the GMHI and the hiPCA on a longitudinal COVID-19 cohort and highlight the distinct robustness of our method to sequencing depth. Conclusions Overall, we emphasize the potential of this metagenomic approach and advocate a shift toward functional approaches to better understand and assess microbiome health as well as provide directions for future index enhancements. Our method, q2-predict-dysbiosis (Q2PD), is freely available (https://github.com/Kizielins/q2-predict-dysbiosis)."https://cassyni-user-files-prod.s3.amazonaws.com/7FsDLjPsyZQZoT99Tn4cd4 https://cassyni.com/events/24DdyFKRQL49ij9aBTf6eR/abstract https://cassyni-user-files-prod.s3.amazonaws.com/HCdmK3uZZfbcqJj1wPyVX4 https://cassyni.com/events/GQ2aRjdYdbTWvSxyJB7S1B/abstract https://cassyni-user-files-prod.s3.amazonaws.com/WtN8rEWQhQMsECERjfGu4i https://cassyni.com/slides/outline/DSDpVXJ4Cvv4ejXHBYwsMF https://cassyni.com/events/DSDpVXJ4Cvv4ejXHBYwsMF/abstract https://cassyni-user-files-prod.s3.amazonaws.com/DWovWxvDgTdJWG1azUQite https://cassyni.com/events/DSDpVXJ4Cvv4ejXHBYwsMF?videoPreview=1 A hive divided: how space and species sculpt stingless bee microbiomesnohttps://cassyni.com/events/DSDpVXJ4Cvv4ejXHBYwsMF?videoPreview=12026-01-20T15:00:00+00:00795.6Microbiome Virtual International ForumStudying host-associated microbiome assembly is key to understanding microbial and host evolution and health. While honey bee microbiome have been a central model for such investigations among pollinators, they overlook the diversity of eusocial dynamics and multi-kingdom interactions. Stingless bees—a diverse group of highly eusocial insects that includes managed species, varies in colony biology, and harbors a symbiotic yeast essential for larval development in at least one species—offer a valuable complementary system to study microbiome assembly under an eco-evolutionary context. Using amplicon sequencing, metagenomics, and microbial experiments, we investigate the drivers of microbiome assembly in stingless bee colonies. We reveal a spatially structured, site-adapted microbiome, where high microbial influx hive components are segregated from the brood, which harbors a stable, multi-kingdom community. We show that the brood microbiome is not only physically protected but also maintained through selective bacterial-fungal interactions and abiotic conditions shaped by bees and their symbionts, such as temperature and pH. Our findings uncover multi-layered mechanisms shaping eusocial superorganism microbiomes, from host biology to cross-kingdom interactions, while providing critical insights into microbiome maintenance of important pollinators.https://cassyni-user-files-prod.s3.amazonaws.com/DWovWxvDgTdJWG1azUQite https://cassyni.com/events/BSUscyacwJisvn7cjQrzU5/abstract https://cassyni-user-files-prod.s3.amazonaws.com/GEWtKASFhBHYgSHqe9TSwp https://cassyni.com/events/BSUscyacwJisvn7cjQrzU5?videoPreview=1 Green Market Transformation: Learning to LEED, at Indiana Universitynohttps://cassyni.com/events/BSUscyacwJisvn7cjQrzU5?videoPreview=12022-09-12T08:00:00+00:003283.36 School of Public PolicyDelivered at the Ostrom Workshop, Indiana University, on September 12th, 2022.https://cassyni-user-files-prod.s3.amazonaws.com/GEWtKASFhBHYgSHqe9TSwp https://cassyni.com/events/BwBitvFvBV8UaF9bh2RTnM/seminar/qa https://cassyni.com/slides/outline/BwBitvFvBV8UaF9bh2RTnM https://cassyni.com/events/BwBitvFvBV8UaF9bh2RTnM/abstract https://cassyni-user-files-prod.s3.amazonaws.com/5PRriNpQanw7xXRUiALaPQ https://cassyni.com/events/BwBitvFvBV8UaF9bh2RTnM?videoPreview=1 The Fluctuation-Dissipation Relations: Growth, Diffusion, and Beyondnohttps://cassyni.com/events/BwBitvFvBV8UaF9bh2RTnM?videoPreview=12025-11-06T05:00:00+00:002504.84Physics ReportsIn this review, we scrutinize historical and modern results on the linear response of dynamical systems to external perturbations with a particular emphasis on the celebrated relationship between fluctuations and dissipation expressed by the fluctuation–dissipation theorem (FDT). The conceptual foundation of FDT originates from the definition of the equilibrium state and Onsager’s regression hypothesis. Over time, the fluctuation–dissipation relation has been vividly investigated also in systems far from equilibrium, which often exhibit wild fluctuations in measured parameters. In this review, we recall the major formulations of the FDT, including those proposed by Langevin, Onsager and Kubo. We discuss the role of fluctuations in a broad class of growth and diffusion phenomena and examine the violation of the FDT resulting from a transition from Euclidean to fractal geometry. Finally, we highlight possible generalizations of the FDT formalism and discuss situations where the relation breaks down and is no longer applicable.https://cassyni-user-files-prod.s3.amazonaws.com/5PRriNpQanw7xXRUiALaPQ https://cassyni.com/slides/outline/ViZ6gA4hPKzTjofbxaAXWV https://cassyni.com/events/ViZ6gA4hPKzTjofbxaAXWV/abstract https://cassyni-user-files-prod.s3.amazonaws.com/CmRBy9AFGotpF5Nm7uCwDQ https://cassyni.com/events/ViZ6gA4hPKzTjofbxaAXWV?videoPreview=1 Rewinding the tape: historical contingency and functional constraints have shaped the evolution of APikL virulence effectors in the blast fungusnohttps://cassyni.com/events/ViZ6gA4hPKzTjofbxaAXWV?videoPreview=12025-12-06T07:00:00+00:002198.2Royal Society PublishingProtein evolution is influenced by historical contingencies and functional constraints, but their combined impact on rapidly diversifying pathogen virulence effectors remains poorly understood. Here, we combined ancestral state reconstructions and functional assays to recapitulate the evolution of the MAX-fold effector protein APikL2 of the plant pathogenic blast fungus Magnaporthe (syn. Pyricularia) oryzae, focusing on the ancestral and functionally critical amino acid residue D66 (Asp, Codon: GAT). "Rewinding the tape" experiments based on ancestral sequence resurrection revealed that, out of the seven potential amino acid substitutions derived from single nucleotide polymorphisms, only the naturally occurring D66N (Asp to Asn, GAT to AAT) expanded the binding spectrum to host plant proteins of the heavy metal associated (HMA) family. In contrast, three of the nonsynonymous substitutions were deleterious resulting in loss of binding to HMA proteins. Additionally, we identified three cases of homoplasy in the APikL effector family, involving HMA-binding interfaces, indicating recurrent convergent evolution. Our findings suggest an experimental framework for predicting evolutionary outcomes of pathogen effector-host target interactions with implications for plant disease resistance breeding.https://cassyni-user-files-prod.s3.amazonaws.com/CmRBy9AFGotpF5Nm7uCwDQ https://cassyni.com/slides/outline/9ygbAjmP8j3Rd3DiXtZupR https://cassyni.com/events/9ygbAjmP8j3Rd3DiXtZupR/abstract https://cassyni-user-files-prod.s3.amazonaws.com/6AHvigCuVnhkjC8VFedArJ https://cassyni.com/events/9ygbAjmP8j3Rd3DiXtZupR?videoPreview=1 Evolutionary Dynamics Within The Honey Bee Gut Microbiome Via Longitudinal Metagenomicsnohttps://cassyni.com/events/9ygbAjmP8j3Rd3DiXtZupR?videoPreview=12026-03-24T14:00:00+00:00802.24Microbiome Virtual International Forum Host-associated microbial communities are shaped by a combination of evolutionary and ecological processes. Within honey bees, broad-scale ecological dynamics of bee-associated bacteria have been extensively studied through 16S rRNA gene-based analyses. However, little is known about how honey bee-associated bacteria evolve over time. Here, we utilize longitudinally-sampled metagenomics from 12 individual honey bee colonies to quantify the ecological and evolutionary dynamics of >300 bacterial species within and across honey bee colonies over the course of one year. We find that honey bee microbial communities are highly specific to the colony of origin, and that measures of ecological and evolutionary diversity are highly stable with respect to changes in season. Adapting standard population genetic models of evolutionary processes, we find that bee-associated microbial species accumulate genetic differences within bees that can be reliably distinguished from incidents of strain replacement. By tracking high-quality polymorphic alleles, we find that bacterial species commonly generate myriad, smaller evolutionary changes, including nucleotide variants that rapidly sweep to high frequency. We further show that the majority of these sweeps cannot be explained by stochastic processes (e.g. drift). Finally, we provide evidence that while purifying selection is dominant within the honey bee gut microbiome, a large number of these allelic sweeps occur simultaneously in spatially and taxonomically distant bacterial hosts, highlighting potential convergent, adaptive responses in the honey bee gut microbiome.https://cassyni-user-files-prod.s3.amazonaws.com/6AHvigCuVnhkjC8VFedArJ https://cassyni.com/slides/outline/42nS3MPdkoLpFu3myCqRxy https://cassyni.com/events/42nS3MPdkoLpFu3myCqRxy/abstract https://cassyni-user-files-prod.s3.amazonaws.com/6WwQW3SLDjrjMvsagz1Rze https://cassyni.com/events/42nS3MPdkoLpFu3myCqRxy?videoPreview=1 Proof-of-principle for human sex-linked bacteria in multiple sclerosis: Female-linked bacterium Eggerthella lenta drives Th1 response and disease via TLR2nohttps://cassyni.com/events/42nS3MPdkoLpFu3myCqRxy?videoPreview=12026-04-21T00:30:00+00:00385.52Microbiome Virtual International ForumWomen face increased risk of autoimmune disease. The human gut microbiota also differs by biological sex; however, the degree to which sex differences in the gut microbiota impact autoimmunity remains largely unexplored. A meta-analysis of 27 human cohorts revealed 91 sex-associated gut bacterial species. The top two female-enriched species, Eisenbergiella [Dialister] tayi and Eggerthella lenta, were more abundant in multiple sclerosis (MS) patients than healthy controls and positively associated with disease. E. lenta significantly worsened disease in the experimental autoimmune encephalomyelitis (EAE) mouse model, consistent with T cell infiltration and interferon-γ (IFN-γ) in the brain and T helper 1 (Th1) and T helper 17 (Th17) immune responses in the gut. E. lenta induced intestinal Th1 and Th17 signatures in healthy mice, independent of bacterial viability. TLR2 directly drives IFN-γ production in helper T cells in response to E. lenta in vitro and is necessary for E. lenta’s effect in EAE. Together, these results support a causal role for E. lenta-mediated TLR2 activation in intestinal and brain immune activation, potentially contributing to MS development. This study provides proof-of-concept for select human gut microbiota members contributing to sex biases in autoimmunity and a foundation to explore impacts of other sex-associated bacterial species.https://cassyni-user-files-prod.s3.amazonaws.com/6WwQW3SLDjrjMvsagz1Rze https://cassyni.com/slides/outline/14fprDPPuAcNNvwfiLM1ND https://cassyni.com/events/14fprDPPuAcNNvwfiLM1ND/abstract https://cassyni-user-files-prod.s3.amazonaws.com/TfsCjHwFPTgfiKURMAQBJv https://cassyni.com/events/14fprDPPuAcNNvwfiLM1ND?videoPreview=1 Construction of deformed anisotropic compact star models coupled with the quadratic equation of state in Einstein's theory of gravitynohttps://cassyni.com/events/14fprDPPuAcNNvwfiLM1ND?videoPreview=12026-05-14T19:00:00+00:001392.84Annals of PhysicsIn the present study, two new anisotropic solutions are obtained within the Einstein's gravity by employing the minimal geometric deformation technique. To achieve this, we start with an anisotropic fluid serving as the seed source within a static, spherically symmetric fluid interior. As a way to introduce the additional source's gravitational coupling to the original matter content, we add a corresponding Lagrangian density. By using a modification to the radial metric component to the field equations characterizing both fluids, two separate sets of equations are obtained. A couple of novel analytical solutions are produced by solving each system separately using some unique constraints. By comparing the interior and exterior geometries, the integration constants of the solutions are found. After that, the suggested models' fundamental properties are graphically displayed through the estimated radius and mass of a star candidate $Vela~X-1$. We deduce that the anisotropic models constructed in this investigation meet all requirements for physical acceptability within the selected range of the decoupling parameter.https://cassyni-user-files-prod.s3.amazonaws.com/TfsCjHwFPTgfiKURMAQBJv https://cassyni.com/slides/outline/LKz1mW8kRP8hEyh5PS8iEZ https://cassyni.com/events/LKz1mW8kRP8hEyh5PS8iEZ/abstract https://cassyni-user-files-prod.s3.amazonaws.com/M4QyX6TcU33RizFDJB5HVg https://cassyni.com/events/LKz1mW8kRP8hEyh5PS8iEZ?videoPreview=1 Addressing Cervical Cancer Screening Disparities: At-Home Self-Collection Among LGBQ+ Populationsnohttps://cassyni.com/events/LKz1mW8kRP8hEyh5PS8iEZ?videoPreview=12026-06-15T18:00:00+00:00913.2Sage PublishingBackground: Over 20 million people in the U.S. are behind on cervical cancer screenings (CCS). Sexual minority populations are 50% less likely to engage in routine screening, putting them at higher risk for cervical dysplasia and cancer due to undetected precancer and delayed diagnosis. Their barriers to speculum exams include access to care, sexual trauma, and provider bias. At-home HPV self-collection (SC) offers a clinically accurate, preferred alternative screening method. Objective: To assess clinical agreement, usability, and screening experiences and preferences for an FDA-authorized at-home vaginal SC device among participants who identify as lesbian, gay, bisexual, pansexual, queer, or other non-heterosexual identities (LGBQ+). Methods: SELF-CERV was a prospective, multi-site method-comparison study conducted across 16 U.S. sites. Participants completed SC in a simulated at-home setting and underwent clinician collection with a speculum and cervical brush; paired specimens were tested for primary HPV using the Roche cobas. Surveys assessed barriers to screening, prior screening experiences, usability, and preferences. 609 participants were enrolled; 599 had paired samples, including 74 LGBQ+ participants. Results: Compared with heterosexual participants, LGBQ+ participants more frequently delayed or avoided screening, had lower preventive care engagement, and described worse prior speculum-based screening experiences, including higher pain, discomfort, and aversion. Clinical agreement between self- and clinician-collected specimens was comparable, with no unanticipated safety concerns. The SC device was rated as easy to use and acceptable across groups; LGBQ+ participants reported greater comfort and empowerment and a stronger preference for at-home self-collection. Qualitative comments emphasized privacy and reduced distress, including trauma- and dysphoria-related concerns. Conclusion: At-home SC is a clinically valid, usable, and strongly preferred CCS option, particularly among LGBQ+ populations who experience disproportionate barriers to speculum-based CCS. Broader adoption of FDA-authorized at-home SC paired with telehealth will enable future impact assessment to reduce persistent disparities in CCS for LGBQ+ populations.https://cassyni-user-files-prod.s3.amazonaws.com/M4QyX6TcU33RizFDJB5HVg https://cassyni.com/events/XCFJnYNJ5TKAmFX6zyNQBP/abstract https://cassyni-user-files-prod.s3.amazonaws.com/3pFAU14oimLyEMGdc1Dsdp https://cassyni.com/slides/outline/PnYsCvBJtww76NTGEmLqgH https://cassyni.com/events/PnYsCvBJtww76NTGEmLqgH/abstract https://cassyni-user-files-prod.s3.amazonaws.com/2WvfV24D6DPHYMEFiAiNmU https://cassyni.com/events/PnYsCvBJtww76NTGEmLqgH?videoPreview=1 Pollutant biodegradation profile mediated by multi-trophic microbial dynamics in riversnohttps://cassyni.com/events/PnYsCvBJtww76NTGEmLqgH?videoPreview=12026-06-02T00:30:00+00:00538.24Microbiome Virtual International ForumMicrobial communities and environmental conditions are closely linked to ecosystem functions and directly govern the biodegradation of pollutants in aquatic environments. However, the role of multi-trophic interactions and their spatiotemporal dynamics in these processes remains poorly understood. Here, we examined how seasonal and spatial variations, mediated by trophic interactions within benthic microbial communities, influence their composition, functional capacity, and collective potential to degrade a diverse array of organic pollutants in rivers. By characterizing both prokaryotic (i.e., archaea and bacteria) and eukaryotic taxa (i.e., algae, fungi, protists, and metazoans), and inferring metabolic pathways, we explored the connections between community composition and pollutant degradation in wastewater-receiving rivers across four seasons. Mediation analysis revealed that variation in multi-trophic community structure statistically mediates the total effect of environmental factors on the biodegradation profiles of 96 organic pollutants, with prokaryotic communities explaining 60% of the total environmental influence. Eukaryotic groups also showed significant indirect mediation effects, with fungal, protistan, algal, and metazoan communities accounting for 56%, 53%, 26%, and 38% of the mediated effect, respectively. Across the two rivers studied, spatial variation explained more of the variance in community composition than seasonality did over the sampled year. Together, these results provide ecosystem-level insights into how multi-trophic microbial community organization is associated with pollutant biodegradation potential in dynamic river environments and support the development of predictive frameworks for sustainable water management.https://cassyni-user-files-prod.s3.amazonaws.com/2WvfV24D6DPHYMEFiAiNmU https://cassyni.com/slides/outline/HNBFqHoFzibEyGFPGoy9ad https://cassyni.com/events/HNBFqHoFzibEyGFPGoy9ad/abstract https://cassyni-user-files-prod.s3.amazonaws.com/X8TqqjEc4iJUtGoTcWZeFG https://cassyni.com/events/HNBFqHoFzibEyGFPGoy9ad?videoPreview=1 Particle-beam-driven plasma wakefield accelerationnohttps://cassyni.com/events/HNBFqHoFzibEyGFPGoy9ad?videoPreview=12026-09-10T11:00:00+00:003229.8Physics ReportsThe extensive research in particle-beam-driven plasma wakefield acceleration has progressed along three primary pathways: electron-driven, positron-driven, and proton-driven wakefield generation. Several accelerator facilities worldwide have made significant contributions to research and progress in this field, with remarkable milestones achieved. Together, these three pathways are strategically advancing toward their ultimate applications in future compact particle colliders and X-ray light sources. This talk will review the fundamental concepts, major experimental milestones, and current status of beam-driven plasma wakefield acceleration, based on our comprehensive review paper recently published in Physics Reports.​‌https://cassyni-user-files-prod.s3.amazonaws.com/X8TqqjEc4iJUtGoTcWZeFG https://cassyni.com/events/3YVvUrSdZ2q7ou3fFwxvMB/abstract https://cassyni-user-files-prod.s3.amazonaws.com/W3MDVFaH6rxYAKosm76134 https://cassyni.com/slides/outline/GPkMHSUgbzCFTyaoQLLLv9 https://cassyni.com/events/GPkMHSUgbzCFTyaoQLLLv9/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Nncd3S2VYNc3giYzXGrkeS https://cassyni.com/events/GPkMHSUgbzCFTyaoQLLLv9?videoPreview=1 The Elephant in the Room: Fluid Dynamics in the age of Machine Learningnohttps://cassyni.com/events/GPkMHSUgbzCFTyaoQLLLv9?videoPreview=12023-12-07T15:00:00+00:003974.64The Edinburgh Fluid Dynamics Group (EFDG)"With four parameters I can fit an elephant, and with five I can make him wiggle his trunk," said John von Neumann in a powerful exhortation that physical models should contain only a handful of parameters. A century later, we seem happy to use physics-agnostic neural networks containing millions of parameters. What would von Neumann say? How should physical modellers respond? In this talk, I will frame a response within a Bayesian framework, in which physical principles such as conservation of mass and momentum are expressed as high quality prior information with quantified uncertainties. I will show how Bayesian inference becomes computationally tractable when combined with adjoin methods, and demonstrate this through assimilation of 3D Flow-MRI data directly into CFD, and selection of models in an acoustic problem.https://cassyni-user-files-prod.s3.amazonaws.com/Nncd3S2VYNc3giYzXGrkeS https://cassyni.com/slides/outline/25HJKAu6i3FmJzhjmubDED https://cassyni.com/events/25HJKAu6i3FmJzhjmubDED/abstract https://cassyni-user-files-prod.s3.amazonaws.com/TtMLLi3QK93WHbRsvydgVC https://cassyni.com/events/25HJKAu6i3FmJzhjmubDED?videoPreview=1 AI and research: a promising relationship? nohttps://cassyni.com/events/25HJKAu6i3FmJzhjmubDED?videoPreview=12024-05-16T08:00:00+00:005465.0The Research on Research (RoR) TeamThe event was a sell out with 250 registered and more than 100 people attending on the day.https://cassyni-user-files-prod.s3.amazonaws.com/TtMLLi3QK93WHbRsvydgVC https://cassyni.com/events/HshARVRFvMruthZvFm1ko7/seminar/qa https://cassyni.com/slides/outline/HshARVRFvMruthZvFm1ko7 https://cassyni.com/events/HshARVRFvMruthZvFm1ko7/abstract https://cassyni-user-files-prod.s3.amazonaws.com/WwvDNBwxrE19nmJTGpqBwk https://cassyni.com/events/HshARVRFvMruthZvFm1ko7?videoPreview=1 Older Age and Advanced Kidney Diseasenohttps://cassyni.com/events/HshARVRFvMruthZvFm1ko7?videoPreview=12024-03-14T14:00:00+00:005439.04Imperial College Renal and Transplant CentreOur leading expert will use 4 patient stories to illustrate learning points in ethics, frailty, dementia, supportive care and patient expectations. Schedule: 1. 14:00-14:20 Ethics Focused Patient Story 2. 14:20-14:40 Frailty and Advanced Kidney Care and Dialysis 3. 14:40-15:00 Supportive Assisted Peritoneal Dialysis and Dementia 4. 15:00-15:20 Inpatient Care and Patient Expectations 5. 15:20 General Discussion with Delegate Questionshttps://cassyni-user-files-prod.s3.amazonaws.com/WwvDNBwxrE19nmJTGpqBwk https://cassyni.com/slides/outline/DvnZCKPvSJh2ZWVQkVCoHF https://cassyni.com/events/DvnZCKPvSJh2ZWVQkVCoHF/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Dudxr7cyB5YFJQhuK7vYQe https://cassyni.com/events/DvnZCKPvSJh2ZWVQkVCoHF?videoPreview=1 TADF Emitters for Organic Light-Emitting Diodesnohttps://cassyni.com/events/DvnZCKPvSJh2ZWVQkVCoHF?videoPreview=12025-05-23T11:00:00+00:003762.72Thieme India ChemTalksOrganic Light-Emitting Diodes (OLEDs) represent a state-of-the-art technology in display and lighting systems, leveraging organic semiconducting materials to emit light in response to an electric current. Unlike traditional liquid crystal displays (LCDs), OLEDs are self-emissive, enabling deeper blacks, higher contrast ratios, and more vivid color reproduction. Key advantages of OLEDs include their lightweight structure, mechanical flexibility, foldability, rapid response times, and wide viewing angles, features that make them particularly well-suited for applications in smartphones, televisions, and wearable electronics. The ability to fabricate OLEDs on flexible substrates also enables innovative form factors, such as foldable phones and rollable screens. A significant advancement in OLED material development is the emergence of thermally activated delayed fluorescence (TADF) emitters, categorized as third-generation emitters. TADF is a photophysical process that enables the utilization of triplet excitons via reverse intersystem crossing (RISC), driven by ambient thermal energy. By designing molecules with a small singlet–triplet energy gap (ΔEst), efficient up conversion of non-radiative triplet excitons into radiative singlet states becomes feasible. The ability of TADF emitters to achieve 100% internal quantum efficiency (IQE), coupled with a metal-free molecular framework, positions them as highly attractive alternatives to conventional fluorescent and phosphorescent materials. The efficiency of TADF processes is strongly dependent on the RISC rate (kRISC), which is maximized by minimizing ΔEst. This is typically achieved through rational donor–acceptor molecular design, which simultaneously enhances charge transport and optimizes emission properties. Our research focuses on the development of next-generation TADF emitters with tailored photophysical properties, high photoluminescence quantum yield (PLQY), efficient charge mobility, and improved device longevity, targeting high-performance, fully organic OLED displays and lighting systems.https://cassyni-user-files-prod.s3.amazonaws.com/Dudxr7cyB5YFJQhuK7vYQe