https://cassyni.com/events/7sbJMH5mSCZtMEmZtjqaCV/abstract https://cassyni-user-files-prod.s3.amazonaws.com/6mH6VaAgtqYixye46WUkPp https://cassyni.com/slides/outline/6PT8QpXzJJRYyrBoKR1JCV https://cassyni.com/events/6PT8QpXzJJRYyrBoKR1JCV/abstract https://cassyni-user-files-prod.s3.amazonaws.com/2C1mgicKQDB6Hzh7SuH2op https://cassyni.com/events/6PT8QpXzJJRYyrBoKR1JCV?videoPreview=1 Understanding Discourse Analysisnohttps://cassyni.com/events/6PT8QpXzJJRYyrBoKR1JCV?videoPreview=12023-04-28T04:10:00+00:002172.84Linguistics and Applied Language StudiesDiscourse analysis is a useful research tool for understanding how people communicate and is employed within a range of disciplines. In this seminar I explore what discourse analysis is and outline four key approaches to analysing discourse: Corpus Approaches to Discourse Analysis, Conversation Analysis, Interactional Sociolinguistics and Critical Discourse Studies. All are grounded in social constructionist theory: as we communicate we construct the social world. However, examples from research around the world demonstrate how the choice of which approach to use is not simply a case of randomly picking one. These approaches prioritise different types of data, typically utilise different analytical tools and techniques, as well as exploring varying issues and answering different questions. Each approach provides a unique lens with which to examine discourse and all generate useful insights about how we communicate. This research survey draws on my new textbook, and we invite you to help celebrate the publication of this book: Understanding Discourse Analysis (Routledge, 2023).https://cassyni-user-files-prod.s3.amazonaws.com/2C1mgicKQDB6Hzh7SuH2op https://cassyni.com/events/KEN5qrPQWvgEtngrs3yoq7/seminar/qa https://cassyni.com/slides/outline/KEN5qrPQWvgEtngrs3yoq7 https://cassyni.com/events/KEN5qrPQWvgEtngrs3yoq7/abstract https://cassyni-user-files-prod.s3.amazonaws.com/AFKvX4e18dTzPvXbCgM5Pc https://cassyni.com/events/KEN5qrPQWvgEtngrs3yoq7?videoPreview=1 Flat optics: arbitrary wavefront control with passive and active metasurfaces and metalenses for high volume applicationsnohttps://cassyni.com/events/KEN5qrPQWvgEtngrs3yoq7?videoPreview=12023-04-18T13:00:00+00:004688.24MetaMATI will discuss metasurfaces that enable light’s spin and orbital angular momentum to evolve along the propagation direction and nonlocal supercell designs that demonstrate multiple independent optical functions at arbitrary large deflection angles with high efficiency. 2D phase and polarization singularities (“structured dark”) have been realized, as well as 0D singularities. I will present active metasurfaces for high-speed optical modulation at telecom wavelengths based on electrooptic polymers and Si and give the state-of-the-art of commercial metalenses including their high-volume manufacturing for consumer electronics. Finally, I will discuss our recent work on metalenses for the EUV ( 50 nm wavelength) based on vacuum guiding.https://cassyni-user-files-prod.s3.amazonaws.com/AFKvX4e18dTzPvXbCgM5Pc https://cassyni.com/slides/outline/S9SYVRSkfLS2PbgSEVYjyo https://cassyni.com/events/S9SYVRSkfLS2PbgSEVYjyo/abstract https://cassyni-user-files-prod.s3.amazonaws.com/FaGQR3T96DCqPa5wwzeaBY https://cassyni.com/events/S9SYVRSkfLS2PbgSEVYjyo?videoPreview=1 The instruments of expeditionary science and the reworking of nineteenth-century magnetic experimentnohttps://cassyni.com/events/S9SYVRSkfLS2PbgSEVYjyo?videoPreview=12023-02-23T16:00:00+00:003055.04Royal Society PublishingDuring the mid-nineteenth century, British naval expeditions navigated the world as part of the most extensive scientific undertaking of the age. Between 1839 and the early 1850s, the British government orchestrated a global surveying of the Earth's magnetic phenomena: this was a philosophical enterprise of unprecedented state support and geographical extent. But to conduct this investigation relied on the use of immensely delicate instruments, known as ‘dipping needles’. The most celebrated of these were those of Robert Were Fox, designed and built in Cornwall. Yet these devices were difficult to physically maintain and ensuring accuracy throughout a magnetic experiment was challenging. In 2020, Crosbie Smith and I took an original Fox dipping needle on a voyage from Falmouth to Cape Town, retracing the routes of survey expeditions, including James Clark Ross's 1839–43 Antarctic venture. The article offers an account of our experiences, combined with historical reports of the instrument's past performances. It explores the instrumental challenges involved in nineteenth-century global experimental investigation. The great problem for the British magnetic survey was of coordinating standardized experimental measurements over vast expanses of space and time. As this article argues, this was very much a question of instrumental management, both of dipping needles and of human performers.https://cassyni-user-files-prod.s3.amazonaws.com/FaGQR3T96DCqPa5wwzeaBY https://cassyni.com/events/FHBFUPDD1GF678EBTwPmED/seminar/qa https://cassyni.com/slides/outline/FHBFUPDD1GF678EBTwPmED https://cassyni.com/events/FHBFUPDD1GF678EBTwPmED/abstract https://cassyni-user-files-prod.s3.amazonaws.com/GaKyaVN647TXtHRDwm4sjU https://cassyni.com/events/FHBFUPDD1GF678EBTwPmED?videoPreview=1 The use of wavelet-based optical flows for wall-bounded turbulent flowsnohttps://cassyni.com/events/FHBFUPDD1GF678EBTwPmED?videoPreview=12023-06-13T14:00:00+00:003180.28Experiments in FluidsExperimental investigations of turbulent boundary layer flows requires the ability to resolve the velocity at high spatial resolution down to the wall. Particle image velocimetry (PIV) has been the workhorse of experimental fluid mechanics for many decades. However, the principles of cross-correlation based PIV often make it challenging to resolve the viscous sublayer with sufficient vector resolution, while still being able to resolve a significant portion of the velocity in the outer boundary layer regions. Optical flow is an alternative approach to velocimetry; it describes the apparent displacement of brightness intensity patters in an image sequence, and it is capable of determining the velocity field with impressive vector resolution down to the pixel scale. Originally developed by the computer vision community, variants of optical flow have been adopted within the fluid mechanics research community. However, in comparison to PIV, optical flow is far-less developed and applied within experimental fluid mechanics, since it is often more intimidating to learn and develop. Thus, the capabilities of optical flow and the understanding of how to best develop optical flow for accurate velocity estimations is often lacking. In this seminar, we will evaluate the capacity of wOF to resolve a turbulent boundary layer flow field with high accuracy and impressive spatial resolution. We will first assess the sensitivity of wOF findings to the regularization parameter (λ). This analysis will describe the effect of under-regularization or over-regularization for accurate measurements of velocity and wall shear stress, the latter of which is important for calculation of non-dimensional boundary layer parameters. This analysis is performed on synthetic DNS data of a turbulent channel flow. wOF findings will be compared with PIV as a benchmark to discuss wOF’s performance against the state-of-the-art. wOF will then be applied and assessed to experimental particle images acquired within a turbulent boundary layer. We will discuss the optimization of wOF in the absence of ground-truth data, and the capability of wOF to extend beyond PIV as well as particle tracking velocimetry, when wOF parameters are chosen appropriately. https://cassyni-user-files-prod.s3.amazonaws.com/GaKyaVN647TXtHRDwm4sjU https://cassyni.com/slides/outline/9r3bxs6SBEA1iFyws2PyEm https://cassyni.com/events/9r3bxs6SBEA1iFyws2PyEm/abstract https://cassyni-user-files-prod.s3.amazonaws.com/349aWuzVAm9DYWCLRVTDyp https://cassyni.com/events/9r3bxs6SBEA1iFyws2PyEm?videoPreview=1 ELI Teacher Snapshotsnohttps://cassyni.com/events/9r3bxs6SBEA1iFyws2PyEm?videoPreview=12023-08-04T04:10:00+00:002871.52Linguistics and Applied Language StudiesEnglish Language Institute (ELI) teachers will have 2-3 minutes to share what they have recently been working on. Come hear about the ELI's diverse programmes and groups of learners.https://cassyni-user-files-prod.s3.amazonaws.com/349aWuzVAm9DYWCLRVTDyp https://cassyni.com/events/QfXMU124kKh67MPifdomjT/seminar/qa https://cassyni.com/slides/outline/QfXMU124kKh67MPifdomjT https://cassyni.com/events/QfXMU124kKh67MPifdomjT/abstract https://cassyni-user-files-prod.s3.amazonaws.com/2yKiNa9jiLpiGfB9tjbyNn https://cassyni.com/events/QfXMU124kKh67MPifdomjT?videoPreview=1 High-molecular-weight disinfection by-productsnohttps://cassyni.com/events/QfXMU124kKh67MPifdomjT?videoPreview=12023-05-10T14:00:00+00:003583.08Nature WaterChlorination is an effective way to disinfect water and reduce the potential impact of waterborne diseases. However, the addition of chlorine to water increases the generation of disinfection by-products. Although research is quite established for low carbon content DBPs, higher molecular weight compounds, which are less known, are likely to have a substantial impact on water quality. We shall discuss current knowledge on these compounds with William Mitch (Stanford University), Susan Richardson (South Carolina University) and Maria José Farré (ICRA, Barcelona), exploring the formation, potential environmental hazard and risk assessment. This event is supported by the WeChat channel: Environmentor 2017 https://cassyni-user-files-prod.s3.amazonaws.com/2yKiNa9jiLpiGfB9tjbyNn https://cassyni.com/events/T8mNhRFgwcTuCqCqd2xWRK/seminar/qa https://cassyni.com/slides/outline/T8mNhRFgwcTuCqCqd2xWRK https://cassyni.com/events/T8mNhRFgwcTuCqCqd2xWRK/abstract https://cassyni-user-files-prod.s3.amazonaws.com/KCkEfjLD1DYi1AhArJHD7c https://cassyni.com/events/T8mNhRFgwcTuCqCqd2xWRK?videoPreview=1 Water through the agesnohttps://cassyni.com/events/T8mNhRFgwcTuCqCqd2xWRK?videoPreview=12023-07-06T14:00:00+00:003625.32Nature WaterIn the special event of the Nature Water Talks series, we’ll talk to two researchers who strive to reach out to wide audiences. Fabio Pulizzi will ask Peter Gleick (author of "The three ages of water") and Giulio Boccaletti (author of "Water, a biography") about their vision for the future of water based on what we have learned from history, as well as the excitement and challenges of writing books that will be read by audiences beyond the research community. The webinar is supported by the Environmentor WeChat channel.https://cassyni-user-files-prod.s3.amazonaws.com/KCkEfjLD1DYi1AhArJHD7c https://cassyni.com/events/NgxZPtwrPrQRaBVWstdSQu/seminar/qa https://cassyni.com/slides/outline/NgxZPtwrPrQRaBVWstdSQu https://cassyni.com/events/NgxZPtwrPrQRaBVWstdSQu/abstract https://cassyni-user-files-prod.s3.amazonaws.com/KLBMfNjcTGHTbo1dyqxqUi https://cassyni.com/events/NgxZPtwrPrQRaBVWstdSQu?videoPreview=1 Losing My Religion: How Organized Religion Continues to Control and Shape Black Women’s Identitynohttps://cassyni.com/events/NgxZPtwrPrQRaBVWstdSQu?videoPreview=12023-09-07T16:00:00+00:003404.08Lived Places PublishingWith a contemporary statistical decline in church attendance, in both the USA and the UK, religious institution’s power over people’s lives still remains strong. The (white) Christian church is undoing rights for minoritized groups and women’s bodily autonomy. A 2023 documentary, _Shiny Happy People_, speaks to the patriarchal control that the religious organization, The Institute of Basic Life Principles (IPBL), exercised over girls and women’s bodies, minds and autonomy. Though there were a small number of Black people that were a part of that church, none of them were interviewed for the documentary. The impact of organized religious institutions and the patriarchy used to shape and control our identities was missing from the documentary and largely missing in the public discourse. Let’s change that by talking about the good, the bad and the ugly or religion’s impact on the shaping of Black women’s identities. The discussion will draw from Dr. Pow's recently published book, *[Stories of Black Female Identity in the Making: Queering the Love in Blackness](https://livedplacespublishing.com/book/isbn/9781915271471?utm_source=MB&utm_medium=Web&utm_campaign=black-studies&utm_content=Pow)*, which is an exploration of how Black identity is constantly formed and reformed, along with intersections of gender and sexuality. https://cassyni-user-files-prod.s3.amazonaws.com/KLBMfNjcTGHTbo1dyqxqUi https://cassyni.com/slides/outline/YZveKZtMB1UkRhVYPTPoYq https://cassyni.com/events/YZveKZtMB1UkRhVYPTPoYq/abstract https://cassyni-user-files-prod.s3.amazonaws.com/HtCf3BgpxVctU9sQtcvFGi https://cassyni.com/events/YZveKZtMB1UkRhVYPTPoYq?videoPreview=1 Integrating Symbolic Simulation of C/C++ into a Comprehensive EDA Verification Environmentnohttps://cassyni.com/events/YZveKZtMB1UkRhVYPTPoYq?videoPreview=12023-09-12T13:00:00+00:001434.64HiPEDS CentreFormal verification of chip designs - once thought to be an impractical dream - has matured through many years of technological innovation, investment, and experience into a mainstream verification tool used across the semiconductor design industry. Mature and highly capable tools, with rich debugging environments, are available from the EDA vendors - and the technology continues to advance. This talk will tell the story of how a software verification tool for C programs - the CMBC bounded model checker developed by Daniel Kroening - was leveraged to integrate C/C++ symbolic simulation into a commercial formal verification environment. The aim of this project was to move beyond an academic prototype and enable equivalence checking of digital circuit models against real-world C/C++ reference model code – with full access to the proof engines, verification control, and debugging tools of a leading commercial verification environment. https://cassyni-user-files-prod.s3.amazonaws.com/HtCf3BgpxVctU9sQtcvFGi https://cassyni.com/events/TdSbrjR6nRwj2bnCNygoph/seminar/qa https://cassyni.com/slides/outline/TdSbrjR6nRwj2bnCNygoph https://cassyni.com/events/TdSbrjR6nRwj2bnCNygoph/abstract https://cassyni-user-files-prod.s3.amazonaws.com/SPNg13fAUdz2bGbZQPejd8 https://cassyni.com/events/TdSbrjR6nRwj2bnCNygoph?videoPreview=1 Structural power composites - the route to more electric aircraftnohttps://cassyni.com/events/TdSbrjR6nRwj2bnCNygoph?videoPreview=12023-10-06T12:00:00+00:003396.84Brahmal Vasudevan Institute for Sustainable AviationElectrification of aircraft is recognised as a key aspiration for mitigating the impact of aviation on the climate emergency. However, the slow pace of battery development, particularly the elevation of energy and power densities, and the immaturity of emerging battery technologies, is hindering the move towards more electric aircraft. An alternative strategy is to reduce the energy demands of future vehicles through adoption of multifunctional materials: these offer tremendous opportunities for light weighting and innovative design. In particular, the emergence of structural composites imbued with electrochemical functions (e.g. structural batteries) presents compelling opportunities for efficient energy storage by negating the parasitic weight associated with conventional devices. This presentation will introduce structural power composites and the motivation for their development, illustrating the potential applications for this technology. The hurdles to maturing structural power composites will be presented, and the presentation will culminate in outlining potential adoption routes for this exciting technology. https://cassyni-user-files-prod.s3.amazonaws.com/SPNg13fAUdz2bGbZQPejd8 https://cassyni.com/events/2w2PYZ4rqYFms9VTrm6i93/seminar/qa https://cassyni.com/slides/outline/2w2PYZ4rqYFms9VTrm6i93 https://cassyni.com/events/2w2PYZ4rqYFms9VTrm6i93/abstract https://cassyni-user-files-prod.s3.amazonaws.com/VxiQVpk8TDKkRbiKFGGdGa https://cassyni.com/events/2w2PYZ4rqYFms9VTrm6i93?videoPreview=1 Tracking in 3D: from dense point particles to concentrated polydispersed bubblesnohttps://cassyni.com/events/2w2PYZ4rqYFms9VTrm6i93?videoPreview=12024-01-23T15:00:00+00:003134.2Experiments in FluidsThis talk delves into the development of open-sourced 3D tracking methods applicable to both point tracer particles and finite-sized polydispersed bubbles. The primary challenge in optical tracking lies in addressing complexities arising from overlapped particle and bubble images, particularly as concentrations increase. The evolution of 3D tracking methods, from classical triangulation-then-tracking methods to the modern Shake-the-Box technique that incorporates intensity and temporal information, underscores the importance of leveraging comprehensive image information to reduce tracking ambiguities. This paper explores the optimal integration of information, including intensity, shape, and reflection features, into the tracking code for both point particles and complex-shaped ones. The integration of such multifaceted information enhances the tracking method's capabilities, extending its applicability to complex multiphase flows characterized by polydispersed, non-spherical, or deformable dispersed phases.https://cassyni-user-files-prod.s3.amazonaws.com/VxiQVpk8TDKkRbiKFGGdGa https://cassyni.com/events/CozUUE1MchL6ifVVNKs5Gy/seminar/qa https://cassyni.com/slides/outline/CozUUE1MchL6ifVVNKs5Gy https://cassyni.com/events/CozUUE1MchL6ifVVNKs5Gy/abstract https://cassyni-user-files-prod.s3.amazonaws.com/KhfZStUFnMhXrXyyMzrEPQ https://cassyni.com/events/CozUUE1MchL6ifVVNKs5Gy?videoPreview=1 Mixed Race, Mixed Messages: The Growing Identity Crisis of Multiracial Americans in an Increasingly Racially Divided Countrynohttps://cassyni.com/events/CozUUE1MchL6ifVVNKs5Gy?videoPreview=12023-10-26T16:00:00+00:003055.56Lived Places PublishingIn this conversation between **Chris McAuley**, Black Studies Collection Editor at Lived Places Publishing and **Steve Majors**, author of *A Multiracial Experience: One Man's Search for Race, Identity and Family*, they discuss how the growing number of Americans who identify as multiracial are navigating their experiences of living in a society that is increasingly fractured along persistent, rigid racial lines. https://cassyni-user-files-prod.s3.amazonaws.com/KhfZStUFnMhXrXyyMzrEPQ https://cassyni.com/slides/outline/T7CX8eAvXXAKSYJhcbqrd https://cassyni.com/events/T7CX8eAvXXAKSYJhcbqrd/abstract https://cassyni-user-files-prod.s3.amazonaws.com/GEBh7oy1Hhz888AeuWcPm8 https://cassyni.com/events/T7CX8eAvXXAKSYJhcbqrd?videoPreview=1 Introducing Transformative Plant Biotechnology: Panel discussion session: What is Transformative Plant Biotechnology?nohttps://cassyni.com/events/T7CX8eAvXXAKSYJhcbqrd?videoPreview=12023-09-20T13:30:00+00:002396.88The New Phytologist FoundationNo abstracthttps://cassyni-user-files-prod.s3.amazonaws.com/GEBh7oy1Hhz888AeuWcPm8 https://cassyni.com/events/JFBND19uFTGzpFEJsBsams/seminar/qa https://cassyni.com/slides/outline/JFBND19uFTGzpFEJsBsams https://cassyni.com/events/JFBND19uFTGzpFEJsBsams/abstract https://cassyni-user-files-prod.s3.amazonaws.com/RGTmLL1RoTe2ZQQfR9F8gW https://cassyni.com/events/JFBND19uFTGzpFEJsBsams?videoPreview=1 Kidney Beam for people using dialysis therapynohttps://cassyni.com/events/JFBND19uFTGzpFEJsBsams?videoPreview=12024-03-14T16:00:00+00:002792.04Imperial College Renal and Transplant CentreNo abstracthttps://cassyni-user-files-prod.s3.amazonaws.com/RGTmLL1RoTe2ZQQfR9F8gW https://cassyni.com/slides/outline/V7SfE3PSuXTULX4LUj7Gih https://cassyni.com/events/V7SfE3PSuXTULX4LUj7Gih/abstract https://cassyni-user-files-prod.s3.amazonaws.com/JPJ6CASeGmaik647RpmU9t https://cassyni.com/events/V7SfE3PSuXTULX4LUj7Gih?videoPreview=1 The Aaberg Exhaust: or why you don’t suck out your birthday candlesnohttps://cassyni.com/events/V7SfE3PSuXTULX4LUj7Gih?videoPreview=12022-11-18T12:00:00+00:001885.0UK Fluids NetworkNo abstracthttps://cassyni-user-files-prod.s3.amazonaws.com/JPJ6CASeGmaik647RpmU9t https://cassyni.com/slides/outline/KEWCQzxqXjJsdUkiFjHMDP https://cassyni.com/events/KEWCQzxqXjJsdUkiFjHMDP/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Be4qFVeUVFtV5ePX4PaUqC https://cassyni.com/events/KEWCQzxqXjJsdUkiFjHMDP?videoPreview=1 An update on an energy-based multiscale modelling framework for physiology.nohttps://cassyni.com/events/KEWCQzxqXjJsdUkiFjHMDP?videoPreview=12024-05-01T00:00:00+00:003670.04Auckland Bioengineering InstituteBond graphs provide a useful level of abstraction for modelling protein function for a wide range of physiological processes, such as metabolic reactions, membrane transporters, ion channels, myofilament mechanics, receptors and signalling, etc. In this talk I will show how bond graph templates (that conserve mass, charge and energy, respectively) are developed for enzyme-catalysed metabolic reactions, the sodium-potassium ATPase pump, and some of the members of the SLC transporter superfamily (including glucose transport, glutamate transport, sodium-calcium exchange, and sodium-hydrogen exchange). These can be parameterised for a specific cell and tissue type for which the experimental kinetic data is available. I will also show how analytic expressions can be derived for a representative four- or six-state model, given reasonable assumptions associated with steady state flux conditions, while always preserving thermodynamic consistency. Finally, based on work with Weiwei Ai and David Nickerson (Andre), I will present details on fitting parameters for the glucose transporters to experimental data and show how well the steady state flux expressions match the full kinetic analysis. https://cassyni-user-files-prod.s3.amazonaws.com/Be4qFVeUVFtV5ePX4PaUqC https://cassyni.com/events/5QMH7rr9EuoPzJJ1M3vwUZ/abstract https://cassyni-user-files-prod.s3.amazonaws.com/34LCJZGbPpcmJgtQHHxFDQ https://cassyni.com/slides/outline/HGPNAy8od2qqRLqF7PuRYR https://cassyni.com/events/HGPNAy8od2qqRLqF7PuRYR/abstract https://cassyni-user-files-prod.s3.amazonaws.com/AemdA8MRcLnLQtZWxR7A2J https://cassyni.com/events/HGPNAy8od2qqRLqF7PuRYR?videoPreview=1 Strain and Strain rate-dependent Mechanical Metamaterialsnohttps://cassyni.com/events/HGPNAy8od2qqRLqF7PuRYR?videoPreview=12024-05-07T13:00:00+00:003658.04MetaMATGenerally, after the manufacturing process, the mechanical behaviors of a meta-structure or material are set and are hardly modified. Nevertheless, materials and structures with varying static or dynamical mechanical properties are attractive to many engineering fields. In this talk, I will introduce two types of mechanical metamaterials with tunable mechanical performances under large compressive deformations, one is strain-dependent mechanical metamaterial and another one is strain rate-dependent mechanical metamaterial. The tunable mechanical performances mean the tunable effective Young's modulus and Poisson's ratio (auxeticity), both of which are fundamental mechanical properties of materials. For the strain-dependent mechanical metamaterial, the corresponding theoretical model of their effective Young's modulus and Poisson's ratio were established, and the mechanism of their mechanical tunability has been explained. More importantly, simulation results demonstrate that the strain-dependent metamaterial has the potential for designing metamaterials exhibiting tunable phononic band gaps. For the strain rate-dependent mechanical metamaterial, we design a solid structure that displays unidirectional shock resistance, thus going beyond Newton’s second law in analogy to non-Newtonian fluids. We design the mechanical metamaterial with finite element analysis and fabricate it using three-dimensional printing at the centimetric scale (with fused deposition modeling) and at the micrometric scale (with two-photon lithography). The non-Newtonian elastic response is measured via dynamical velocity-dependent experiments. Reversing the direction of the impact, we further highlight the intrinsic non-reciprocal response. https://cassyni-user-files-prod.s3.amazonaws.com/AemdA8MRcLnLQtZWxR7A2J https://cassyni.com/events/Y5qVZUYYnmTBfxYcdSNnQV/seminar/qa https://cassyni.com/slides/outline/Y5qVZUYYnmTBfxYcdSNnQV https://cassyni.com/events/Y5qVZUYYnmTBfxYcdSNnQV/abstract https://cassyni-user-files-prod.s3.amazonaws.com/9ndpKvyFqnp7owXr9d9WHk https://cassyni.com/events/Y5qVZUYYnmTBfxYcdSNnQV?videoPreview=1 Adoptive cell immunotherapies for cancernohttps://cassyni.com/events/Y5qVZUYYnmTBfxYcdSNnQV?videoPreview=12024-05-14T14:00:00+00:004971.04Research Seminars by Springer NatureIn this webinar, our panelists will discuss recent developments and challenges for adoptive cell therapies for cancer treatment. Our speakers will introduce the different therapeutic approaches (tumor-infiltrating lymphocytes-therapy, chimeric antigen receptor (CAR)-T, CAR-NK, CAR-macrophages). The presentations will be followed by a panel discussion and Q&A session. The webinar will be hosted by [Nature Communications](https://www.nature.com/ncomms/) and [Communications Medicine](https://www.nature.com/commsmed) editors. The journals also invite you to consider the related collection on [Immune cell engineering for cancer therapy](https://www.nature.com/collections/dahdifegah), welcoming future submissions.https://cassyni-user-files-prod.s3.amazonaws.com/9ndpKvyFqnp7owXr9d9WHk https://cassyni.com/events/5uUU7FFjXW6r96r6kQTeXX/seminar/qa https://cassyni.com/slides/outline/5uUU7FFjXW6r96r6kQTeXX https://cassyni.com/events/5uUU7FFjXW6r96r6kQTeXX/abstract https://cassyni-user-files-prod.s3.amazonaws.com/U7WDJEAtsnGH46ojTiZ4ke https://cassyni.com/events/5uUU7FFjXW6r96r6kQTeXX?videoPreview=1 Transition in the Hypersonic Boundary Layernohttps://cassyni.com/events/5uUU7FFjXW6r96r6kQTeXX?videoPreview=12024-06-18T13:00:00+00:003570.16AIAA JournalThe transition in the hypersonic boundary layer represents a pivotal area of interest within the fluid mechanics community. This talk provides a review of the recent advancements in hypersonic boundary-layer transition studies, encompassing research facilities and experimental methodologies. It introduces the hypersonic quiet wind tunnel as an essential tool for acquiring near-space real flight data. Techniques for near-wall measurement, including temperature-sensitive paint, near-wall particle image velocimetry, infrared thermography, and Rayleigh-scattering visualization, are explored. The talk addresses critical issues in hypersonic boundary layer transitions, focusing on the instability and nonlinear interaction among various instability modes. It proposes the phase-locked mechanism of these instability modes and introduces a novel principle of aerodynamic heating in hypersonic flows. Additionally, it thoroughly discusses the structural formation of boundary layers over flat plates, sharp cones, flared cones, and delta wings.https://cassyni-user-files-prod.s3.amazonaws.com/U7WDJEAtsnGH46ojTiZ4ke https://cassyni.com/events/PCCEqoQzHtQjdg4zWR2Bi5/seminar/qa https://cassyni.com/slides/outline/PCCEqoQzHtQjdg4zWR2Bi5 https://cassyni.com/events/PCCEqoQzHtQjdg4zWR2Bi5/abstract https://cassyni-user-files-prod.s3.amazonaws.com/QKdJj71jqyaA8uQ6kXR5u8 https://cassyni.com/events/PCCEqoQzHtQjdg4zWR2Bi5?videoPreview=1 Emerging Trends in Glycoscience, Part #2nohttps://cassyni.com/events/PCCEqoQzHtQjdg4zWR2Bi5?videoPreview=12024-11-12T15:00:00+00:007102.64Thieme GroupCarbohydrates are essential biomolecules with significant roles in chemistry, biology, and medicine. The "Emerging Trends in Glycoscience" issue highlights advancements in synthetic carbohydrate chemistry and their applications. It features 22 contributions, including reviews and original research, covering topics like molecular scaffolding, catalysis, and medicinal chemistry, providing insights into carbohydrate-based pharmacological developments. Our speakers: Prof. Xi Chen (University of California, Davis): Advances in Chemoenzymatic Synthesis of Sialosides Prof. Alexei Demchenko (Saint Louis University): From Stereocontrolled Glycosylation to Automated Chemical Synthesis https://cassyni-user-files-prod.s3.amazonaws.com/QKdJj71jqyaA8uQ6kXR5u8 https://cassyni.com/events/W7GhVNULSJAX8V4Zsrb7rm/seminar/qa https://cassyni.com/slides/outline/W7GhVNULSJAX8V4Zsrb7rm https://cassyni.com/events/W7GhVNULSJAX8V4Zsrb7rm/abstract https://cassyni-user-files-prod.s3.amazonaws.com/3XBqnTgj58TVUPaU6CYCUE https://cassyni.com/events/W7GhVNULSJAX8V4Zsrb7rm?videoPreview=1 Particles floating on turbulent waternohttps://cassyni.com/events/W7GhVNULSJAX8V4Zsrb7rm?videoPreview=12024-09-24T14:00:00+00:003014.64Experiments in FluidsEvery year, millions of tons of plastics enter the ocean. Devising effective strategies to mitigate such pollution requires the quantitative understanding of how floating particles travel and spread in turbulent waters. Past studies have mostly focused on the influence exerted by the surface on the flow underneath, while the characterization of the transport along the surface remains incomplete. I will summarize our recent experiments using laboratory and field-scale facilities. Microscopic particles faithfully follow the free surface flow, revealing a rich structure that shares similarities with both three-dimensional and two-dimensional turbulence, as well as unique features. In particular, due to the compressibility of the surface velocity field, the particles cluster over a wide range of spatial and temporal scales. For millimetre-sized particles, capillarity-driven attraction breaks the equilibrium between cluster formation and breakup, leading to aggregates that grow steadily in size. Even larger particles filter the small-scale velocity fluctuations, which results in a more time-correlated motion and, in turn, faster dispersion. https://cassyni-user-files-prod.s3.amazonaws.com/3XBqnTgj58TVUPaU6CYCUE https://cassyni.com/slides/outline/3SG4zTXzjaG5ve4wVHVTSD https://cassyni.com/events/3SG4zTXzjaG5ve4wVHVTSD/abstract https://cassyni-user-files-prod.s3.amazonaws.com/9K3sdAuQi3TdhZ5kwRYmaW https://cassyni.com/events/3SG4zTXzjaG5ve4wVHVTSD?videoPreview=1 When Less is More? Entropy Based Subsampling for Big Datanohttps://cassyni.com/events/3SG4zTXzjaG5ve4wVHVTSD?videoPreview=12024-07-24T15:00:00+00:003198.04Journal of Statistical Theory and PracticeIn many real-life situations, not all information carries equal importance or significance. The variations and diversity among instances within a dataset contribute to its meaningfulness and value. In Information Theory, the entropy captures the uncertainty and amount of information in a dataset, highlighting the importance of diverse and informative instances. In practical terms, reducing the full dataset to a smaller, informative subset and conducting the same analysis can often yield similar estimation efficiency. However, the key challenge with such subsampling technique lies in striking the right balance between reducing computational cost and potential loss in efficiency. For multiple linear regression models, traditional subsampling techniques like leveraging methods have primarily measured information loss based only on covariates (design matrix) excluding the responses and thus often lead to a loss of statistical estimation accuracy. Unlike the idea of only keeping the subsample, the problem is viewed as extracting a representative set of the full data in terms of entropy. Two methods are presented: (i) a Likelihood-based Optimal Subsample Selection (LBOSS) given a desired sub-sample size; and (ii) a Bayesian-based Optimal Subsample Selection (BBOSS) which automatically determines the subsample size using posterior distribution. The proposed entropy-based criteria not only provide a better measure of the information loss due to subsampling but are also applicable to any likelihood-based estimation methods. In addition to some theoretical guarantees of the proposed methods, we provide extensive numerical illustrations to compare the proposed methods with some of the recently published methods in the literature. In terms of computational efficiency and statistical accuracy, the proposed methods are shown to perform relatively better.https://cassyni-user-files-prod.s3.amazonaws.com/9K3sdAuQi3TdhZ5kwRYmaW https://cassyni.com/events/AMLXe2bLsz1sRT4Wrj4Pau/abstract https://cassyni-user-files-prod.s3.amazonaws.com/MAQZqFehYr3o7fEgWYXaJa https://cassyni.com/slides/outline/MiJfw1WBnEbtufaTYwMVLZ https://cassyni.com/events/MiJfw1WBnEbtufaTYwMVLZ/abstract https://cassyni-user-files-prod.s3.amazonaws.com/GTPUTACqmUHV4Vn5wUzLvS https://cassyni.com/events/MiJfw1WBnEbtufaTYwMVLZ?videoPreview=1 Ethical dimensions of microbiome researchnohttps://cassyni.com/events/MiJfw1WBnEbtufaTYwMVLZ?videoPreview=12024-05-21T10:00:00+00:001758.0Microbiome Virtual International Forum Panel discussion of the Ethical dimensions of microbiome research eventhttps://cassyni-user-files-prod.s3.amazonaws.com/GTPUTACqmUHV4Vn5wUzLvS https://cassyni.com/events/6trYYW6ScVzGbjHkYHXknq/seminar/qa https://cassyni.com/slides/outline/6trYYW6ScVzGbjHkYHXknq https://cassyni.com/events/6trYYW6ScVzGbjHkYHXknq/abstract https://cassyni-user-files-prod.s3.amazonaws.com/7Hwkdt9Aws9agsRHt7cPX4 https://cassyni.com/events/6trYYW6ScVzGbjHkYHXknq?videoPreview=1 Predicting and optimizing wave motion in spatially graded structuresnohttps://cassyni.com/events/6trYYW6ScVzGbjHkYHXknq?videoPreview=12024-10-15T13:00:00+00:003545.04MetaMATPeriodic metamaterials and architected materials have emerged as powerful tools for, among others, controlling or suppressing elastic waves by bandgap engineering. However, wave guidance can also be achieved without bandgaps. Moreover, the manufacturable design space extends far beyond periodic structures. Spatially graded architectures with smoothly varying unit cell designs have hardly been explored for wave manipulation but offer a rich playground for wave manipulation. We here present a combined experimental-computational study into this rich design space at the example of spatially graded beam lattices. We confirm experimentally that Bloch-Floquet theory is an accurate approximation, as long as the grading in unit cell design is smooth. We further introduce ray tracing for dispersive elastic media as a convenient numerical approach to predict and optimize wave motion in graded structures. As an example, we demonstrate how conformal mappings can be exploited to create spatially graded structures which are capable of low-pass wave attenuation and wave guidance. Moreover, we discuss how computational design optimization can lead to interesting and peculiar wave motion in graded structural networks.https://cassyni-user-files-prod.s3.amazonaws.com/7Hwkdt9Aws9agsRHt7cPX4 https://cassyni.com/slides/outline/JjiUoAjt5U8Bu29yGch1Zo https://cassyni.com/events/JjiUoAjt5U8Bu29yGch1Zo/abstract https://cassyni-user-files-prod.s3.amazonaws.com/ETnjfbsuCmAHUPzeB6Xvd4 https://cassyni.com/events/JjiUoAjt5U8Bu29yGch1Zo?videoPreview=1 Enhancing Computational Fluid Dynamics with Machine Learningnohttps://cassyni.com/events/JjiUoAjt5U8Bu29yGch1Zo?videoPreview=12022-08-19T12:00:00+00:00973.56Brunton LabIn this video we discuss the recent article published in Nature Computational Science by Ricardo Vinuesa and Steve Brunton, where the potential of machine learning (ML) to improve numerical simulations of fluid flows is discussed. In particular, we show the possibilities enabled by ML in the context of 1) accelerating direct numerical simulations (DNSs); 2) improving turbulence modeling for large-eddy simulations (LESs) and Reynolds-averaged Navier–Stokes (RANS) simulations; and also enhancing the development of reduced-order models (ROMs). Focusing on the latter, we describe a deep-learning framework for learning a minimal and near-orthogonal set of non-linear modes in the context of turbulent flows. In particular, we focus on a high-fidelity numerical database of a simplified urban environment. The proposed technique relies on β-variational autoencoders (β-VAEs) and convolutional neural networks (CNNs), which enable extracting non-linear modes while encouraging the learning of statistically-independent latent variables and penalizing the size of the latent vector. We demonstrate that by constraining the shape of the latent space, it is possible to motivate orthogonality and extract a set of parsimonious modes which enable high-quality reconstruction. This method exhibits an excellent performance in the reconstruction against linear-theory-based decompositions, where the energy percentage captured by the proposed method from five modes is equal to 87.36% against 32.41% from proper-orthogonal decomposition (POD).https://cassyni-user-files-prod.s3.amazonaws.com/ETnjfbsuCmAHUPzeB6Xvd4 https://cassyni.com/slides/outline/UcgZiqgNrdCWkY9znBTNhj https://cassyni.com/events/UcgZiqgNrdCWkY9znBTNhj/abstract https://cassyni-user-files-prod.s3.amazonaws.com/8jY9ZEppoQ5G31hWhvKt5k https://cassyni.com/events/UcgZiqgNrdCWkY9znBTNhj?videoPreview=1 Abstract Categorical Logicnohttps://cassyni.com/events/UcgZiqgNrdCWkY9znBTNhj?videoPreview=12023-02-22T15:00:00+00:004117.44Logica UniversalisWe present in this talk an abstract categorical logic based on an abstraction of quantifier. More precisely, the proposed logic is abstract because no structural constraints are imposed on models (semantics free). By contrast, formulas are inductively defined from an abstraction both of atomic formulas and of quantifiers. In this sense, the proposed approach differs from other works interested in formalizing the notion of abstract logic and of which the closest to our approach are the institutions, which in addition to be semantics free do not also impose any syntactic contingencies on the structure of formulas. To define the semantical framework in which formulas will be interpreted, we propose to follow the idea from categorical logic which defines the semantical interpretation of formulas from context and as subobjects of an object of a given category. In the spirit of Lawvere’s hyperdoctrines, we use a more abstract notion which generalizes the notion of subobject, standard in category theory: Pitt’s prop-categories. Always in the spirit of categorical logic, we propose a sequent calculus of which we show correctness and completeness for all semantical frameworks defined over any prop-categories. We then study some conditions which allow us to get this completeness result for particular classes of prop-categories.https://cassyni-user-files-prod.s3.amazonaws.com/8jY9ZEppoQ5G31hWhvKt5k https://cassyni.com/slides/outline/EnXeRhZgZoh37MhHsW6xxu https://cassyni.com/events/EnXeRhZgZoh37MhHsW6xxu/abstract https://cassyni-user-files-prod.s3.amazonaws.com/LRnCMWWdEBTmNRMQzMHrxe https://cassyni.com/events/EnXeRhZgZoh37MhHsW6xxu?videoPreview=1 Anthromes, CO2 and Terrestrial Carbon – Session 3: The role of forest demography & succession in the carbon cyclenohttps://cassyni.com/events/EnXeRhZgZoh37MhHsW6xxu?videoPreview=12023-03-28T19:00:00+00:006089.72The New Phytologist Foundation3.00 – 3.20: Carbon cycling in mature and regrowth forests globally, Kristina Andersen-Teixeira 3.20 – 3.40: Aging forests and weak growth enhancement drive biomass dynamics in US forests, J.Aaron Hogan 3.40 – 4.00: The carbon sink of recovering degraded and secondary forests across the tropics: Science, Satellites and Policy, Viola Heinrich 4.00 – 4.20: Disruption of animal seed dispersal reduces carbon accumulation during tropical forest regrowth, Evan Fricke 4.20 – 4.40: Forest demographic shifts alters drought responses and associated carbon sequestration, Tsun Fung Au https://cassyni-user-files-prod.s3.amazonaws.com/LRnCMWWdEBTmNRMQzMHrxe https://cassyni.com/slides/outline/NCHLEanSZ2vbkQvA7wu91X https://cassyni.com/events/NCHLEanSZ2vbkQvA7wu91X/abstract https://cassyni-user-files-prod.s3.amazonaws.com/HsJd8Ywo5tYme9bCrrfnJJ https://cassyni.com/events/NCHLEanSZ2vbkQvA7wu91X?videoPreview=1 Landscape and flux theory for nonequilibrium biological systemsnohttps://cassyni.com/events/NCHLEanSZ2vbkQvA7wu91X?videoPreview=12021-07-20T09:00:00+00:005183.24Journal of Biological PhysicsIn this talk, I will review recently developed landscape and flux theory as well as its biophysical applications. Together with concepts and tools developed in other areas of nonequilibrium physics, significant progress has been made in unraveling the principles underlying efficient energy transport in photosynthesis, cellular regulatory networks, cellular movements and organization, cell cycle, differentiation and development, cancer, neural network dynamics, population dynamics and ecology, aging, immune responses, and evolution. Here recent advances in nonequilibrium physics are reviewed and their application to biological systems is surveyed. Many of these results are expected to be important as the field continues to build our understanding of life.https://cassyni-user-files-prod.s3.amazonaws.com/HsJd8Ywo5tYme9bCrrfnJJ https://cassyni.com/slides/outline/HFoHmkKCATPaMKCp7UC9HP https://cassyni.com/events/HFoHmkKCATPaMKCp7UC9HP/abstract https://cassyni-user-files-prod.s3.amazonaws.com/6oPVWJ6dB3ZTyVH3K1uDgz https://cassyni.com/events/HFoHmkKCATPaMKCp7UC9HP?videoPreview=1 Experiments with Machine Learning in Fluids Applicationsnohttps://cassyni.com/events/HFoHmkKCATPaMKCp7UC9HP?videoPreview=12023-05-18T10:00:00+00:003392.92Department of AeronauticsApplications of machine learning techniques to physics applications are gaining popularity by providing solution process acceleration, super-resolution, equation discovery, data compression, etc. Different flavors of data driven techniques have been proposed in the literature, in the first part of this talk, I will focus on hybrid approaches in which an existing grid-based numerical technique for solving fluid governing equations is augmented with a neural network correction. It is unclear if these approaches provide improvements over the baseline numerical solver by approximating local subgrid-scale dynamics, by incorporating long-range spatial/temporal correlations or by introducing high-order-like solution reconstructions. Furthermore, it is unclear how different aspects of the training pipeline affect the quality of the neural correction and its generalizability. We investigate the issues above in turbulent channel flow and thermal convection problems. In the second part of the talk, I will focus on the use of convolutional autoencoders to study aerodynamic stall and focus on extreme latent space compression to extract physical insights. We show how physics imprinting (the correlation between latent variable and physical quantities) naturally emerges and is affected by the training database.https://cassyni-user-files-prod.s3.amazonaws.com/6oPVWJ6dB3ZTyVH3K1uDgz https://cassyni.com/slides/outline/Kj3K1AYpMkA4iFgNfA6n1K https://cassyni.com/events/Kj3K1AYpMkA4iFgNfA6n1K/abstract https://cassyni-user-files-prod.s3.amazonaws.com/73iJ2dvPPmqU8mANegbkgW https://cassyni.com/events/Kj3K1AYpMkA4iFgNfA6n1K?videoPreview=1 A stochastic framework for uncertainty quantification and data-enhanced modeling of turbulent flowsnohttps://cassyni.com/events/Kj3K1AYpMkA4iFgNfA6n1K?videoPreview=12023-05-22T10:00:00+00:002736.4Department of AeronauticsThe dynamics of wall-bounded turbulent flows are typically analyzed using the linearized Navier-Stokes equations around base profiles, which either describe a steady-state solution or a long-time averaged mean of a simulation- or experiment-based flow field. Deterministic or stochastic forcing can then be used to compensate for the neglected nonlinear terms and evaluate the input-output features of the linearized dynamics. While uncertainty in the base profile and inputs challenging the effectiveness of linearized models for analysis and flow control, it also presents an opportunity for improving the accuracy of the linearized dynamics in capturing spatio-temporal flow features. We demonstrate how modeling such sources of uncertainty can enable physical discovery and statistical modeling of quantities of interest in two applications involving the analysis and control of complex fluid flows. First, we show how uncertainty quantification with highly structured, random base flow perturbations can uncover transition trends in channel flows. To this end, we build upon an input-output framework for the analysis of linear systems subject to additive and multiplicative sources of uncertainty to provide easily verifiable conditions for the stability and frequency response of the flow dynamics. We then show how stochastic dynamical modeling of additive sources of uncertainty can provide a data-driven refinement of control-oriented models of wind turbine wakes whereby predictions of turbulence intensity variations behind wind the turbines and thrust force and power generation can be improved in accordance with large-eddy simulations of the flow over a cascade of turbines. https://cassyni-user-files-prod.s3.amazonaws.com/73iJ2dvPPmqU8mANegbkgW https://cassyni.com/events/Se7mejcAW9urD4fx2bfiA1/abstract https://cassyni-user-files-prod.s3.amazonaws.com/3YoBZbe1cDhKDVVSw2dkXQ https://cassyni.com/slides/outline/5ttPi2S84veb55DfkUkNGV https://cassyni.com/events/5ttPi2S84veb55DfkUkNGV/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Kar8y6QMCFLmW5hUp4AefQ https://cassyni.com/events/5ttPi2S84veb55DfkUkNGV?videoPreview=1 Presentation of EAJ Issue 12/2 - December 12thnohttps://cassyni.com/events/5ttPi2S84veb55DfkUkNGV?videoPreview=12022-12-12T16:00:00+00:001772.2European Actuarial JournalThe seminar is chaired by Julia Eisenberg and Matthias Scherer.https://cassyni-user-files-prod.s3.amazonaws.com/Kar8y6QMCFLmW5hUp4AefQ https://cassyni.com/events/2SMAPEuSzimx3Nv76pNQjf/abstract https://cassyni-user-files-prod.s3.amazonaws.com/LXYTAZDauZHwg3in58kaMC https://cassyni.com/events/2SMAPEuSzimx3Nv76pNQjf?videoPreview=1 Policy and implementationnohttps://cassyni.com/events/2SMAPEuSzimx3Nv76pNQjf?videoPreview=12023-05-10T12:00:00+00:003874.44Stout Research Centre for New Zealand StudiesWater policy must reflect national values and aspirations, but it is implemented regionally across the country, to an important extent by landowners. James, who until March, was Chief Executive of the Hawke’s Bay Regional Council, will discuss how the implementation conundrum looks to someone returning to central government after a spell in an important agricultural region – one recently devastated by floods.https://cassyni-user-files-prod.s3.amazonaws.com/LXYTAZDauZHwg3in58kaMC https://cassyni.com/slides/outline/4ubBcf95C1YSQKPfeWH3Tb https://cassyni.com/events/4ubBcf95C1YSQKPfeWH3Tb/abstract https://cassyni-user-files-prod.s3.amazonaws.com/W4q98kEbhJ6yCXJM7f5Ly4 https://cassyni.com/events/4ubBcf95C1YSQKPfeWH3Tb?videoPreview=1 Palliative care referral across the disease trajectory in high‑grade gliomanohttps://cassyni.com/events/4ubBcf95C1YSQKPfeWH3Tb?videoPreview=12023-06-26T20:00:00+00:001730.32Journal of Neuro-OncologyJoin Dr. Randy D'Amico and Dr. Jason Sheehan of the Journal of Neuro-Oncology for a discussion with Dr. Caroline Crooms of Mount Sinai and Dr. Jennie Taylor of University of California San Francisco to discuss their latest publication on palliative care referral across the disease trajectory in high‑grade glioma.https://cassyni-user-files-prod.s3.amazonaws.com/W4q98kEbhJ6yCXJM7f5Ly4 https://cassyni.com/events/DJcTQH8zenxRZek8iMc6gV/abstract https://cassyni-user-files-prod.s3.amazonaws.com/3o7z5wTmpwyN3z91BoE1oC https://cassyni.com/slides/outline/CKKFJuqwmsrGttv8cP8msb https://cassyni.com/events/CKKFJuqwmsrGttv8cP8msb/abstract https://cassyni-user-files-prod.s3.amazonaws.com/5iwxig6sPEM2pvrFJVWore https://cassyni.com/events/CKKFJuqwmsrGttv8cP8msb?videoPreview=1 Computation of Proper Elements for the Space Debris Problemnohttps://cassyni.com/events/CKKFJuqwmsrGttv8cP8msb?videoPreview=12022-09-05T12:35:00+00:001009.76Celestial Mechanics and Dynamical AstronomyThe computation of the proper elements of a Hamiltonian system can be done by using perturbation theory techniques. For the space debris problem, the normalization procedure is an iterative method of reducing the initial Hamiltonian system to a simplified form, by removing the fast and semi-fast angles of the model which describes the dynamics of the system. It is worth mentioning that in the space debris problem, the perturbations to be included in the model depend on the altitude of the space debris. The new elements obtained after the normalization process define the proper elements, which are quasi-invariants of motion, hence quantities nearly constant in time. We show that these elements are particularly useful in the classification and back-tracing of space debris, as well as in the possible recognition of their origin. The results are supported by appropriate simulations and data analysis. Work in collaboration with A. Celletti and G.Pucaccohttps://cassyni-user-files-prod.s3.amazonaws.com/5iwxig6sPEM2pvrFJVWore https://cassyni.com/slides/outline/W6gd69eiyiiG4m1yqmVApu https://cassyni.com/events/W6gd69eiyiiG4m1yqmVApu/abstract https://cassyni-user-files-prod.s3.amazonaws.com/3roRRdi47AFEJFiL6mwSsx https://cassyni.com/events/W6gd69eiyiiG4m1yqmVApu?videoPreview=1 What is the Normal Compression of Soil?nohttps://cassyni.com/events/W6gd69eiyiiG4m1yqmVApu?videoPreview=12022-06-20T12:00:00+00:004282.68Granular MatterIt has long been widely accepted that the normal (plastic) compression of sand and clay are very similar: a linear relationship exists beyond some sort of yield point when voids ratio is plotted against the logarithm of applied stress - at least over one log cycle of stress. However the reason for this similarity in behaviour has not been exposed. We present some early thoughts for sand on the evolution of a fractal distribution of particle sizes as stress increases and particles break. Only recently have we been able to explain the normal compression line more clearly and to propose a new linear relationship in log voids ratio - log stress space. The approach recognises the role of the smallest grains, getting smaller and statistically stronger as a grading with a fractal number of 2.5 emerges. However many questions have remained unanswered: why should the fractal number be 2.5, what are the smallest particles (how small is small?) and what about the rest of critical state soil mechanics (peak strength, dilatancy, state boundary surface and so on)? And the important question as to why clay should behave macroscopically in the same way has remained unanswered. In this talk, using DEM we explain the micro mechanics of normal compression of sand, and propose a space-filling argument for why the fractal number should be 2.5. In addition we explain what we mean by the "smallest" particles (because newly formed dust doesn’t contribute to mechanical behaviour). We then introduce a simple attraction/repulsion model for clay platelets and show that a fractal distribution of macro particles evolves as stress increases in order to fill the void space. We believe this is the first time a unifying picture of soil appears to be emerging.https://cassyni-user-files-prod.s3.amazonaws.com/3roRRdi47AFEJFiL6mwSsx https://cassyni.com/slides/outline/8NA345BdfaLrG1jhTg6W8V https://cassyni.com/events/8NA345BdfaLrG1jhTg6W8V/abstract https://cassyni-user-files-prod.s3.amazonaws.com/C9Hwyfy2t6mYD6Gd5p8PeW https://cassyni.com/events/8NA345BdfaLrG1jhTg6W8V?videoPreview=1 Exploiting prunability for person re-identificationnohttps://cassyni.com/events/8NA345BdfaLrG1jhTg6W8V?videoPreview=12021-11-04T12:30:00+00:003091.0Journal on Image and Video ProcessingRecent years have witnessed a substantial increase in the deep learning (DL) architectures proposed for visual recognition tasks like person re-identification, where individuals must be recognized over multiple distributed cameras. Although these architectures have greatly improved the state-of-the-art accuracy, the computational complexity of the convolutional neural networks (CNNs) commonly used for feature extraction remains an issue, hindering their deployment on platforms with limited resources, or in applications with real-time constraints. There is an obvious advantage to accelerating and compressing DL models without significantly decreasing their accuracy. However, the source (pruning) domain differs from operational (target) domains, and the domain shift between image data captured with different non-overlapping camera viewpoints leads to lower recognition accuracy. In this paper, we investigate the prunability of these architectures under different design scenarios. This paper first revisits pruning techniques that are suitable for reducing the computational complexity of deep CNN networks applied to person re-identification. Then, these techniques are analyzed according to their pruning criteria and strategy and according to different scenarios for exploiting pruning methods to fine-tuning networks to target domains. Experimental results obtained using DL models with ResNet feature extractors, and multiple benchmarks re-identification datasets, indicate that pruning can considerably reduce network complexity while maintaining a high level of accuracy. In scenarios where pruning is performed with large pretraining or fine-tuning datasets, the number of FLOPS required by ResNet architectures is reduced by half, while maintaining a comparable rank-1 accuracy (within 1% of the original model). Pruning while training a larger CNNs can also provide a significantly better performance than fine-tuning smaller ones. https://cassyni-user-files-prod.s3.amazonaws.com/C9Hwyfy2t6mYD6Gd5p8PeW https://cassyni.com/events/DoHgZbJQVcSFPRKVUJLQ5s/abstract https://cassyni-user-files-prod.s3.amazonaws.com/DiPzkTQ89dvx1WX6iuVegN https://cassyni.com/slides/outline/PgHPbtkng8SJPR1vGS3CrR https://cassyni.com/events/PgHPbtkng8SJPR1vGS3CrR/abstract https://cassyni-user-files-prod.s3.amazonaws.com/PD9hHZvjmnzKtVbafoY9N6 https://cassyni.com/events/PgHPbtkng8SJPR1vGS3CrR?videoPreview=1 Behavior of a forest of NiFe nanowires in KOH and NaCl solution for water electrolysisnohttps://cassyni.com/events/PgHPbtkng8SJPR1vGS3CrR?videoPreview=12023-11-30T20:00:00+00:002440.32Electrochimica ActaIn the present work, the behaviour of nanostructured electrodes consisting of an array of nanowires made of NiFe alloy is studied in a KOH + 0.5 M NaCl solution. The aim is to explore the possibility of using these electrodes for hydrogen production by seawater electrolysis. The splitting of sea water requires a highly selective electrode on the anode side, where the evolution of molecular chlorine or the formation of other active chlorine compounds can compete with the oxygen evolution reaction. Nanostructured electrodes obtained by template electrosynthesis were tested at room temperature in KOH + 0.5 M NaCl solution and the results were compared with those obtained in pure KOH. The results showed that the electrocatalytic behaviour of the nanostructured NiFe alloy was not affected by the presence of NaCl. Furthermore, the chemical-physical characterisations carried out after the long-term galvanostatic tests have shown that the nanostructured electrodes are also stable in terms of morphology and composition. In addition, the solution used to perform the long-term galvanostatic tests was analysed to investigate the possible formation of chlorine compounds. The absence of these compounds, together with the measurement of the potential value for the oxygen evolution reaction, which was always lower than the thermodynamic redox potential for the hypochlorite formation reaction, leads us to conclude that these electrodes are potentially suitable for seawater electrolysis. https://cassyni-user-files-prod.s3.amazonaws.com/PD9hHZvjmnzKtVbafoY9N6 https://cassyni.com/slides/outline/LDkAH7E7bvZfMiiMcmfFKb https://cassyni.com/events/LDkAH7E7bvZfMiiMcmfFKb/abstract https://cassyni-user-files-prod.s3.amazonaws.com/EVv5TRCfkc3nGfdm88UYra https://cassyni.com/events/LDkAH7E7bvZfMiiMcmfFKb?videoPreview=1 Introducing Transformative Plant Biotechnology: An integrase toolbox to record gene-expression during plant developmentnohttps://cassyni.com/events/LDkAH7E7bvZfMiiMcmfFKb?videoPreview=12023-09-21T09:15:00+00:00812.4The New Phytologist FoundationTo gain a deeper understanding of and engineer plants, the development of synthetic circuits with memory is essential to allow the recording and recoding of in vivo signalling networks. Here, we report on the transfer of serine integrase-based technology to mediate site-specific and irreversible DNA recombination visualized by switching between fluorescent reporters. When combined with promoters expressed during lateral root initiation, integrases amplify the reporter signal and permanently mark all descendants. In addition, we developed a suite of methods to tune the threshold for integrase switching. These tools improve the robustness of integrase-mediated switching with different promoters and the stability of switching behaviour over multiple generations. We are using this integrase toolbox to build history-dependent circuits to decode the order of expression during organogenesis. **Co Authors**: Cassandra J Maranas, Jona C Chu, Jennifer L Nemhauserhttps://cassyni-user-files-prod.s3.amazonaws.com/EVv5TRCfkc3nGfdm88UYra https://cassyni.com/slides/outline/ResondLtRxf4V8J9dPu9Gy https://cassyni.com/events/ResondLtRxf4V8J9dPu9Gy/abstract https://cassyni-user-files-prod.s3.amazonaws.com/H1vjGX1RXfXHEkPuW55YKp https://cassyni.com/events/ResondLtRxf4V8J9dPu9Gy?videoPreview=1 Clinician Engineers - the future of healthcarenohttps://cassyni.com/events/ResondLtRxf4V8J9dPu9Gy?videoPreview=12021-09-22T12:00:00+00:001296.28Discover Applied SciencesDr. Neel Sharma discusses Clinician Engineers - the future of healthcare.https://cassyni-user-files-prod.s3.amazonaws.com/H1vjGX1RXfXHEkPuW55YKp https://cassyni.com/slides/outline/6PbEyy7RK74BiYFei6Jqam https://cassyni.com/events/6PbEyy7RK74BiYFei6Jqam/abstract https://cassyni-user-files-prod.s3.amazonaws.com/HGFXnrqBkPoL5F3Tkqfobc https://cassyni.com/events/6PbEyy7RK74BiYFei6Jqam?videoPreview=1 Competitive removal of PGMs from aqueous solutions via dendrimer modified magnetic nanoparticlesnohttps://cassyni.com/events/6PbEyy7RK74BiYFei6Jqam?videoPreview=12021-01-28T12:00:00+00:002245.52Discover Applied SciencesCompetitive adsorption of Au(III)- Pd(II)-, and Pt(IV)-chlorido species were carried out using generation 3 diaminobutane poly(propylene) imine dendrimer micelle (G3-DM15) and palmitic acid (C15-acid) modified superparamagnetic iron oxide nanoparticles (SPIONs). The efficacy of the adsorbents in the recovery of the three metal chlorido species were tested by varying the solution pH and the contact time. SPIONs modified with both the G3-DM15 and C15-acid were not only stable in very acidic conditions (compared to the unmodified SPIONs) but also selective to Au(III)-Cl species with percentage efficiencies of more than 98%. The adsorption of the three metal chlorido species onto the four adsorbents obeyed the Langmuir isotherm. The unmodified SPIONs (ADS 1) and dendrimer modified SPIONs (ADS 2 and ADS 4) gave the highest maximum adsorption capacities for Au(III)-Cl species [17.07 mg g−1 (ADS 1), 6.48 mg g−1 (ADS 2) and 8.31 mg g−1 (ADS 4)] compared to SPIONs modified with only C15-acid (ADS 3) (1.17 mg g−1). The adsorption kinetics were evaluated using three kinetic models; pseudo-first-order, pseudo-second-order and intraparticle diffusion. The adsorption kinetics for all the three metal chlorido species best fitted the pseudo-second-order kinetics model. Desorption studies showed that all three metal chlorido species can be recovered from the adsorbents.https://cassyni-user-files-prod.s3.amazonaws.com/HGFXnrqBkPoL5F3Tkqfobc https://cassyni.com/events/8rqGDPM3WPpg5UjDFnDUJh/abstract https://cassyni-user-files-prod.s3.amazonaws.com/CBrGyrY8Ni885aoXmTWCXY https://cassyni.com/slides/outline/GGZKue3v6G8Wa4FgDf5Cih https://cassyni.com/events/GGZKue3v6G8Wa4FgDf5Cih/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Wge9Sbo1F7o3cYA1qUfGsG https://cassyni.com/events/GGZKue3v6G8Wa4FgDf5Cih?videoPreview=1 Enhanced sensitivity of electrocorticography during awake craniotomy using a novel circular grid electrodenohttps://cassyni.com/events/GGZKue3v6G8Wa4FgDf5Cih?videoPreview=12023-12-04T21:00:00+00:001833.76Journal of Neuro-OncologyJoin the Journal of Neuro-Oncology Editor in Chief, Dr. Jason Sheehan, and Associate Editor, Dr. Randy D'Amico, for a conversation with Dr. Brin Freund, Dr. William Tatum, and Dr. Alfredo Quinones-Hinojosa from the Mayo Clinic Florida to discuss their latest publication on the enhanced sensitivity of electrocorticography during awake craniotomy using a novel circular grid electrode.https://cassyni-user-files-prod.s3.amazonaws.com/Wge9Sbo1F7o3cYA1qUfGsG https://cassyni.com/slides/outline/AqRgQ7w9GE3SBC1Sck5QjF https://cassyni.com/events/AqRgQ7w9GE3SBC1Sck5QjF/abstract https://cassyni-user-files-prod.s3.amazonaws.com/S4utrZkkjnVd3svCCc41bc https://cassyni.com/events/AqRgQ7w9GE3SBC1Sck5QjF?videoPreview=1 Preprints: possibilities for a new ecosystemnohttps://cassyni.com/events/AqRgQ7w9GE3SBC1Sck5QjF?videoPreview=12024-02-26T16:00:00+00:003901.24DeSci FoundationPosting papers as preprints allows rapid communication of research findings and so speeds up the scientific process. The practice has been common in physics and computational science for over 30 years but is now being embraced by biologists, health scientists and other academic fields. The decoupling of dissemination from peer review that preprints provide is also stimulating evolution of the publishing ecosystem. It has the potential to improve the way in which scientific information is presented, verified, reviewed and curated, as well as benefiting individuals by allowing more multi- dimensional and equitable forms of assessment.https://cassyni-user-files-prod.s3.amazonaws.com/S4utrZkkjnVd3svCCc41bc https://cassyni.com/slides/outline/BL5HSoafhgbVAxYLDBNCzZ https://cassyni.com/events/BL5HSoafhgbVAxYLDBNCzZ/abstract https://cassyni-user-files-prod.s3.amazonaws.com/H2TZooX4pzcqtXU4kWMnra https://cassyni.com/events/BL5HSoafhgbVAxYLDBNCzZ?videoPreview=1 Thermoacoustic instability: acoustic, flame and flow interactionsnohttps://cassyni.com/events/BL5HSoafhgbVAxYLDBNCzZ?videoPreview=12020-12-16T14:00:00+00:004273.24Leeds Institute for Fluid DynamicsThermoacoustic instability is caused by interactions between acoustic waves, flames and flow. It leads to damaging oscillations in the combustors of aero-engines, rocket engines, gas turbines and boilers. Carbon-free fuels like hydrogen and ammonia show increased propensity to thermoacoustic instability, and the design of futuristic aerospace engines is dependent on being able to avoid it. Because of the range of length scales involved – from the tiny flame front wrinkling to the long acoustic wavelengths - computational prediction is a real challenge. This talk will explore the acoustic, flame and flow interactions which underpin thermoacoustic instability. We will consider the response of the flame to acoustic waves, the damping of acoustic waves at area expansions with flow separation, and the importance of “entropy noise” – the noise generated when temperature fluctuations undergo a flow acceleration. The implications for efficient computational prediction will be discussed.https://cassyni-user-files-prod.s3.amazonaws.com/H2TZooX4pzcqtXU4kWMnra https://cassyni.com/slides/outline/MhibXngaKf9dqwXsWrFYJh https://cassyni.com/events/MhibXngaKf9dqwXsWrFYJh/abstract https://cassyni-user-files-prod.s3.amazonaws.com/KFNnWsvvoZ7HQyJ53RgAJi https://cassyni.com/events/MhibXngaKf9dqwXsWrFYJh?videoPreview=1 Oscillations of rotating fluidsnohttps://cassyni.com/events/MhibXngaKf9dqwXsWrFYJh?videoPreview=12022-03-17T12:00:00+00:003612.04Leeds Institute for Fluid DynamicsAfter a broad survey of the subject where I'll introduce the multiple motivations for studying rotating fluids and explain the very special properties of their oscillations, called inertial waves in simplest case, I shall present the recent progresses in the understanding of these oscillations which have been permitted by new high resolution calculations and new analytical approaches. I'll try to keep this talk accessible to non-specialist.https://cassyni-user-files-prod.s3.amazonaws.com/KFNnWsvvoZ7HQyJ53RgAJi https://cassyni.com/slides/outline/LiRPSRPXSk3VBBhsQsnDVo https://cassyni.com/events/LiRPSRPXSk3VBBhsQsnDVo/abstract https://cassyni-user-files-prod.s3.amazonaws.com/AVCk7N4AyAS9Ev969o6p1U https://cassyni.com/events/LiRPSRPXSk3VBBhsQsnDVo?videoPreview=1 Development of an implicit high-order Flux Reconstruction solver for high-speed flows on simplex elementsnohttps://cassyni.com/events/LiRPSRPXSk3VBBhsQsnDVo?videoPreview=12024-01-24T14:00:00+00:001658.36Computer Physics CommunicationsIn this seminar, we explore the frontiers of computational fluid dynamics through the lens of high-order Flux Reconstruction (FR) schemes, tailored for high-speed flow phenomena. The focus is on extending these schemes within the COOLFluiD (Computational Object-Oriented Libraries for Fluid Dynamics) platform to accommodate the intricate dynamics of high Mach number flows over both straight and curved-edged simplex elements. We delve into the intricacies of implementing the FR solver, highlighting its efficiency in accurately capturing complex flow features, even on coarser meshes, and its prowess in handling shock waves with fully implicit time marching procedure. The solver's capability extends to solving compressible flow problems, governed by Euler or Navier-Stokes equations, on triangular and tetrahedral meshes. We present extensive verification of the solver, showcasing its performance across a spectrum of flow speeds, culminating in hypersonic cases up to Mach 9.6. The solver's results, reaching up to $7^{th}$, a.k.a P6, order accuracy for solution polynomials and $3^{rd}$ order, a.k.a Q2, for geometrical representation, have been compared with existing literature, demonstrating favorable outcomes. Authors: Rayan Dhib, Firas Ben Ameur, Ray Vandenhoeck, Andrea Lani and Stefaan Poedts.https://cassyni-user-files-prod.s3.amazonaws.com/AVCk7N4AyAS9Ev969o6p1U https://cassyni.com/slides/outline/XaggTTd56pDxhTXu2R1uSd https://cassyni.com/events/XaggTTd56pDxhTXu2R1uSd/abstract https://cassyni-user-files-prod.s3.amazonaws.com/RJS9f4toQSxF6BbAwUzsXt https://cassyni.com/events/XaggTTd56pDxhTXu2R1uSd?videoPreview=1 Post-hoc explanations for AI in transport planningnohttps://cassyni.com/events/XaggTTd56pDxhTXu2R1uSd?videoPreview=12024-01-24T14:00:00+00:002593.52Imperial College London Early Career Researcher InstituteExplainability is crucial in high-stakes domains because mere high performance might not meet all stakeholders' needs. In transport, a typical high-stakes domain, stakeholders require post-hoc testing to gain deeper insights into the decision-making process, enhanced error-tracing support, and validation of the AI system's trustworthiness. However, there is a gap between the explainability provided by general post-hoc XAI methods and the actual needs in practice. This talk aims to bridge this gap by introducing an XAI framework tailored to meet the requirements of transport stakeholders for different purposes. We will then showcase two transportation application to demonstrate how XAI methods can explain why a tested model does or does not meet the explainability needs in the transport planning domain.https://cassyni-user-files-prod.s3.amazonaws.com/RJS9f4toQSxF6BbAwUzsXt https://cassyni.com/slides/outline/6tGU9HGq9vY1Y1FAWCRoky https://cassyni.com/events/6tGU9HGq9vY1Y1FAWCRoky/abstract https://cassyni-user-files-prod.s3.amazonaws.com/GRynPH1kmiLZLzKezesWM4 https://cassyni.com/events/6tGU9HGq9vY1Y1FAWCRoky?videoPreview=1 Experiences of Racially/Ethnically Diverse Young Breast Cancer Survivors: Preliminary Survey Observationsnohttps://cassyni.com/events/6tGU9HGq9vY1Y1FAWCRoky?videoPreview=12023-04-20T14:00:00+00:003579.6Center for Cancer TrainingThis presentation will discuss preliminary observations from a survey of diverse young breast cancer survivors.https://cassyni-user-files-prod.s3.amazonaws.com/GRynPH1kmiLZLzKezesWM4 https://cassyni.com/slides/outline/wnRgSoamLzz8uXpViip2q https://cassyni.com/events/wnRgSoamLzz8uXpViip2q/abstract https://cassyni-user-files-prod.s3.amazonaws.com/3aNcgaeDfchMkTDabPhZXt https://cassyni.com/events/wnRgSoamLzz8uXpViip2q?videoPreview=1 Quantifying Extinction by Quantifying Biodiversitynohttps://cassyni.com/events/wnRgSoamLzz8uXpViip2q?videoPreview=12024-02-08T10:00:00+00:001872.4Cambridge PrismsSaving biodiversity from extinction is of fundamental importance to people everywhere. Biodiversity must be quantified to demonstrate that mass extinctions have occurred. Diversity estimation turns out to be very difficult because most inventories of communities are too small to catch all of the species. The problem is so hard that researchers continue to use strongly disagreeing strategies. Most aren't helpful. For example, randomly drawing the data down to a least common denominator of data set size (rarefaction) only yields relative diversity estimates. Like most approaches, it is highly inaccurate when most individuals belong to just a few species (so a distribution is uneven). Hill numbers such as Shannon's H and Simpson's D are designed to overweight evenness and minimise the signal of richness. Simple equations called richness indices, such as Chao 1, usually just don't work. I discuss two good solutions to the problem. First, I use simple algebra to derive an equation called the geometric series index. Applying it to a large set of species inventories shows that it has no sample size bias. Second, I discuss properties of an unpublished model of relative abundances that also yields richness estimates. These too are unbiased, but more precise. The distribution is simple, has good theoretical properties, and describes real data accurately. It therefore seems to describe the population dynamics of most ecological communities. The field of biodiversity estimation has been at an impasse for many decades, hindering our understanding of mass extinctions - but unification of the field now seems possible.https://cassyni-user-files-prod.s3.amazonaws.com/3aNcgaeDfchMkTDabPhZXt https://cassyni.com/slides/outline/EHzXqXyhjnqr2amdU5HYAy https://cassyni.com/events/EHzXqXyhjnqr2amdU5HYAy/abstract https://cassyni-user-files-prod.s3.amazonaws.com/GFcSwvFCq7EBZVYdr116yU https://cassyni.com/events/EHzXqXyhjnqr2amdU5HYAy?videoPreview=1 Bi-parameter Potential theory and some applications to holomorphic spacesnohttps://cassyni.com/events/EHzXqXyhjnqr2amdU5HYAy?videoPreview=12023-11-16T15:00:00+00:003572.08Journal of Mathematical SciencesThe bidisc carries its own natural Potential Theories, which are not developed in depth. The main obstructions are the lack of the usual basic tools: covering theorems, maximum principles, inequalities for weighted maximal functions... In the case of the bi-disc, we prove a Capacitary Strong Inequality and deduce from it a characterization of the trace inequalities for a Bessel Potential Space. As a consequence, we characterize the multipliers for the Holomorphic Dirichlet Space on the bidisc. Work in collaboration with Pavel Mozolyako, Karl-Mikael Perfekt, and Giulia Sarfatti.https://cassyni-user-files-prod.s3.amazonaws.com/GFcSwvFCq7EBZVYdr116yU https://cassyni.com/slides/outline/GmEZ4xDKw5cLPXFC1mCAtu https://cassyni.com/events/GmEZ4xDKw5cLPXFC1mCAtu/abstract https://cassyni-user-files-prod.s3.amazonaws.com/4XNZdzcrqmyoF4K8tnfq7c https://cassyni.com/events/GmEZ4xDKw5cLPXFC1mCAtu?videoPreview=1 Hyperconcentrated floods cause extreme gravel transport through the sandy rivers of the Gangetic Plainsnohttps://cassyni.com/events/GmEZ4xDKw5cLPXFC1mCAtu?videoPreview=12024-02-23T12:00:00+00:001137.44Research Seminars by Springer NatureThe Gangetic Plains comprise steep gravelly river channels that transition to low gradient sandy channels 10-40 km downstream of the mountain front. This “gravel-sand transition" is characterized by an abrupt greater-than-one-order-of-magnitude drop in both gradient and sediment grain size, suggesting a degree of long-term stability. However, the stratigraphic record of the gravel-sand transition in the Miocene Siwalik Group demonstrates intermittent transport of coarse gravels tens of kilometres downstream of the transition; such events in contemporary channels would drive channel avulsion(s) and increase flood risk, devastating communities across the plains. We combine sedimentological analysis of Siwalik deposits with entrainment calculations which demonstrate that hyperconcentration is required to transport coarse bedload over low-gradient plains. Transport conditions are attainable when intense monsoon precipitation (a 200- to 1000-year event) is combined with increased suspended sediment concentrations in channels. Predicted climate change and ongoing seismicity increase the likelihood of such extreme events within this century.https://cassyni-user-files-prod.s3.amazonaws.com/4XNZdzcrqmyoF4K8tnfq7c https://cassyni.com/slides/outline/9MWVNhWTMDJpdV4HTbaYSq https://cassyni.com/events/9MWVNhWTMDJpdV4HTbaYSq/abstract https://cassyni-user-files-prod.s3.amazonaws.com/DbqkaHbWV8v3jfMnfUUvS https://cassyni.com/events/9MWVNhWTMDJpdV4HTbaYSq?videoPreview=1 Redlining-associated methylation in breast tumors: the impact of contemporary structural racism on the tumor epigenomenohttps://cassyni.com/events/9MWVNhWTMDJpdV4HTbaYSq?videoPreview=12024-06-20T18:00:00+00:003319.96Center for Cancer TrainingAs a growing number of studies reveal that racial and ethnic minorities are at an increased risk of developing and dying from various acute and chronic diseases, it is increasingly evident that research must be conducted that will reveal the molecular basis of health disparities. Health inequities often reflect social inequities and exploring the complex relationship between exposures to adverse social factors and their biological consequences is imperative. Our group has shown that place-based measures of structural racism (i.e. redlining) have been associated with an increase in breast cancer mortality. We hypothesized that exposure to adverse inequities may drive epigenetic perturbations that affect racial disparities in breast cancer outcomes. Here, I examined the association between contemporary redlining, a measure of structural racism at the neighborhood level, and DNA methylation in breast tumor tissue. My results showed that contemporary redlining is associated with differential methylation in 5 CpG sites. All genes are implicated in breast carcinogenesis, including genes related to inflammation, immune function, and stress response. Further exploration of the top 25 CpG sites, identified interaction of 2 sites by ER status and 1 site was associated with all-cause mortality. In addition, contemporary redlining is associated with epigenetic age acceleration and age acceleration is slightly associated with all-cause mortality. These results identify novel associations between contemporary redlining and the breast tumor DNA methylome. These data are the first to show that structural racism impacts the breast tumor epigenome and provide a strong foundation for further study into how socio-structural determinants “above the skin” influence biological mechanisms “under the skin” and drive disparities. This work will provide new molecular mechanistic insights governing breast cancer disparities and has broader implications for pharmacological treatments and policy interventions that would contribute to the ultimate goal of achieving health equity.https://cassyni-user-files-prod.s3.amazonaws.com/DbqkaHbWV8v3jfMnfUUvS https://cassyni.com/events/BpkWc7k5YW5JzRXr1HVBAm/abstract https://cassyni-user-files-prod.s3.amazonaws.com/4Sw5cMntnHMK5jtEuVkyqg https://cassyni.com/slides/outline/QAzEsqS5vJqu2aU4GCzLwX https://cassyni.com/events/QAzEsqS5vJqu2aU4GCzLwX/abstract https://cassyni-user-files-prod.s3.amazonaws.com/MMjgT18bDEFXRksCnCSCML https://cassyni.com/events/QAzEsqS5vJqu2aU4GCzLwX?videoPreview=1 Innovation in Organic Synthesis in Indianohttps://cassyni.com/events/QAzEsqS5vJqu2aU4GCzLwX?videoPreview=12022-07-14T12:00:00+00:008992.04Thieme GroupOrganic synthesis is a rapidly growing field among chemists in India. We celebrated this development by hosting 3 representatives in this Thieme WebCheminar, underscoring India’s place amongst the innovation leaders in this field.https://cassyni-user-files-prod.s3.amazonaws.com/MMjgT18bDEFXRksCnCSCML https://cassyni.com/slides/outline/UcpgHzFosRq9VEDrArkv61 https://cassyni.com/events/UcpgHzFosRq9VEDrArkv61/abstract https://cassyni-user-files-prod.s3.amazonaws.com/4fh1jSm2Sokfk6h1691AD4 https://cassyni.com/events/UcpgHzFosRq9VEDrArkv61?videoPreview=1 Altitude Physiology - a personal experiencenohttps://cassyni.com/events/UcpgHzFosRq9VEDrArkv61?videoPreview=12022-09-07T14:00:00+00:001768.08Imperial College Renal and Transplant CentreGiven the epidemic of obesity worldwide there is a need for more novel and effective weight loss methods. Altitude is well known to be associated with weight loss and has actually been used as a method of weight reduction in obese subjects. This review demonstrates the critical role of hypoxia inducible factor (HIF) in bringing about reductions in appetite and increases in energy expenditure characteristic of hypobaric hypoxia.https://cassyni-user-files-prod.s3.amazonaws.com/4fh1jSm2Sokfk6h1691AD4 https://cassyni.com/events/Enfkzr97acKfr3m9GBQWMB/abstract https://cassyni-user-files-prod.s3.amazonaws.com/VaSpTGM71owLY6CVkThehU https://cassyni.com/events/FHKN3Xne24siqpJ2rchJcV/abstract https://cassyni-user-files-prod.s3.amazonaws.com/C7jB6FvU21LCMsnPJLGcei https://cassyni.com/slides/outline/NCsQdoc41cNrpSYb7scRGZ https://cassyni.com/events/NCsQdoc41cNrpSYb7scRGZ/abstract https://cassyni-user-files-prod.s3.amazonaws.com/5pTikYRXRRGXxJQhZpBLgW https://cassyni.com/events/NCsQdoc41cNrpSYb7scRGZ?videoPreview=1 Synergistic effects of musking and autohemorrhaging on the duration of death feigning in dice snakes (Natrix tessellata)nohttps://cassyni.com/events/NCsQdoc41cNrpSYb7scRGZ?videoPreview=12024-04-18T12:00:00+00:001231.0Royal Society PublishingPredation exerts a significant selection pressure on prey, shaping a multitude of traits that serve as antipredator defences. In turn, natural selection could favour combinations of antipredator defences with synergistic effects that enhance prey survival. An especially interesting antipredator defence is death feigning (DF), present in a wide variety of taxa and usually characterized by the prey lying motionless often along with defecation, musking, and auto-haemorrhaging. All these aspects of DF should work in conjunction with one another, intensifying the overall effect of the display and in turn facilitating quicker escape. To confirm this hypothesis, we tested 263 dice snakes (Natrix tessellata) directly in the field. We noted the occurrence of smearing faeces and musk and autohaemorrhaging and we measured the duration of DF, expecting to see a negative association between the occurrence of these behaviours and the duration of DF. Our results affirm our hypothesis: dice snakes that smeared themselves in musk and faeces before DF and had auto-haemorrhaging during DF spent significantly less time in DF. Our results highlight the functional integration of antipredator behaviors across different phases of predator-prey interactions, emphasizing the need for future research to prioritize studying the sequential display of behaviors.https://cassyni-user-files-prod.s3.amazonaws.com/5pTikYRXRRGXxJQhZpBLgW https://cassyni.com/events/KjdPQPNRpKcKnHJof5p4GM/seminar/qa https://cassyni.com/slides/outline/KjdPQPNRpKcKnHJof5p4GM https://cassyni.com/events/KjdPQPNRpKcKnHJof5p4GM/abstract https://cassyni-user-files-prod.s3.amazonaws.com/XN3kDYwFSxxt591F7GnGQN https://cassyni.com/events/KjdPQPNRpKcKnHJof5p4GM?videoPreview=1 Adaptive-Mesh Optimizations for Scale-Resolving Simulations using Dynamic Closuresnohttps://cassyni.com/events/KjdPQPNRpKcKnHJof5p4GM?videoPreview=12024-10-14T13:00:00+00:003328.28Sci-Fi-TurboWe present a data-driven approach for computing adjoint-based sensitivities in scale-resolving turbulent simulations. Scale-resolving simulations such as direct numerical simulations (DNS) and large-eddy simulations (LES) are much more computationally expensive than steady models, such as Reynolds-averaged Navier-Stokes (RANS). Each scale-resolving evaluation of a quantity of interest, often a statistical time-average, requires orders of magnitude more computational time and resources than in steady-state. This cost limits the applicability of unsteady simulations to many-query studies, such as shape optimization and mesh adaptation for numerical error control. Furthermore, unsteady adjoints, already an expensive proposition, cannot be directly applied to scale-resolving problems due to their chaotic nature. Our sensitivity-calculation approach does not use unsteady adjoint equations but instead relies on unsteady data to train a corrected turbulence model, which then yields the required adjoint solutions. It is non-intrusive and inexpensive, requiring only a small number of unsteady forward simulations, but sufficiently powerful to capture unsteady effects in the sensitivities. Results for high-order discretizations of the unsteady Navier-Stokes equations, augmented by a corrected Spalart-Allmaras turbulence closure, demonstrate the ability of the approach in driving aerodynamic shape optimization in turbulent-flow conditions, and in adapting unsteady flowfields to target statistical outputs of interest. https://cassyni-user-files-prod.s3.amazonaws.com/XN3kDYwFSxxt591F7GnGQN https://cassyni.com/slides/outline/Sehr3xRmxjN7H6JP2XNzR3 https://cassyni.com/events/Sehr3xRmxjN7H6JP2XNzR3/abstract https://cassyni-user-files-prod.s3.amazonaws.com/XtqUe5HGZ3tMj8rGivhXTL https://cassyni.com/events/Sehr3xRmxjN7H6JP2XNzR3?videoPreview=1 Using Hamilton-Jacobi PDEs for Optimizationnohttps://cassyni.com/events/Sehr3xRmxjN7H6JP2XNzR3?videoPreview=12023-04-07T14:00:00+00:003450.96AI Institute in Dynamic SystemsRecent advances in data-driven modeling approaches have proven highly successful in a wide range of fields in science and engineering. In this talk, I will briefly discuss several ubiquitous challenges with the conventional model development / discretization / parameter inference / model revision loop that our methodology attempts to address. I will present our weak form methodology which has proven to have surprising performance properties. In particular, I will describe our equation learning (WSINDy) and parameter estimation (WENDy) algorithms. Lastly, I will discuss applications to several benchmark problems illustrating how our approach addresses several of the above issues and offers advantages in terms of computational efficiency, noise robustness, and modest data needs (in an online learning context).https://cassyni-user-files-prod.s3.amazonaws.com/XtqUe5HGZ3tMj8rGivhXTL https://cassyni.com/events/2SwEnTj4TJED7QYY6k5gzh/abstract https://cassyni-user-files-prod.s3.amazonaws.com/7G6NBUygeFCp3UdufEexei https://cassyni.com/slides/outline/DKCXoVxc7NQgdgNZiHKNwX https://cassyni.com/events/DKCXoVxc7NQgdgNZiHKNwX/abstract https://cassyni-user-files-prod.s3.amazonaws.com/NVtY8WAHpXVLQ6bewC6cFG https://cassyni.com/events/DKCXoVxc7NQgdgNZiHKNwX?videoPreview=1 Using sparse trajectory data to find Lagrangian Coherent Structures (LCS) in fluid flowsnohttps://cassyni.com/events/DKCXoVxc7NQgdgNZiHKNwX?videoPreview=12024-04-12T14:00:00+00:001225.8Brunton LabThe method of Lagrangian Coherent Structures (LCS) uses particle trajectories in fluid flows to identify coherent structures that govern the behavior of the flow. The typical methods employed to identify LCS rely on a dense grid of numerical tracers which are seeded onto the pre-computed vector fields and advected through time and space. However, in many systems, dense flow field information is not available, and researchers must perform their analyses on a sparse set of tracers that already exist in the flow. For example, if we wish our flow observer to autonomously make decisions based on the flow field information, then the computational expense of the normal LCS identification pipeline is too costly to use. It will need to use only the trajectories of the tracers that it sees in the flow. Motivated by the desire to study flow fields autonomously, this video shows how sparse trajectory data can be leveraged to identify key flow quantities including the velocity gradient, Finite-Time Lyapunov Exponent (FTLE), and Lagrangian-Averaged Vorticity Deviation (LAVD), which are often used to identify LCS.https://cassyni-user-files-prod.s3.amazonaws.com/NVtY8WAHpXVLQ6bewC6cFG https://cassyni.com/slides/outline/FnSZ2vCEJfBAzcr8FyE1fT https://cassyni.com/events/FnSZ2vCEJfBAzcr8FyE1fT/abstract https://cassyni-user-files-prod.s3.amazonaws.com/RUQd3BsSr6h3K5FbBqSx6S https://cassyni.com/events/FnSZ2vCEJfBAzcr8FyE1fT?videoPreview=1 Deep Network Spline Geometrynohttps://cassyni.com/events/FnSZ2vCEJfBAzcr8FyE1fT?videoPreview=12022-04-01T14:00:00+00:004154.08AI Institute in Dynamic SystemsWe study the geometry of deep learning through the lens of approximation theory via spline functions and operators. Our key result is that a large class of deep networks (DNs) can be written as a composition of max-affine spline operators (MASOs), which provide a powerful portal through which to view and analyze their inner workings. For instance, conditioned on the input signal, the output of a MASO DN can be written as a simple affine transformation of the input. This implies that a DN constructs a set of signal-dependent, class-specific templates against which the signal is compared via a simple inner product; we explore the links to the classical theory of optimal classification via matched filters and the effects of data memorization. The spline partition of the input signal space that is implicitly induced by a MASO directly links DNs to the theory of vector quantization (VQ) and K-means clustering, which opens up new geometric avenue to study how DNs organize signals in a hierarchical and multiscale fashion.https://cassyni-user-files-prod.s3.amazonaws.com/RUQd3BsSr6h3K5FbBqSx6S https://cassyni.com/slides/outline/CKuKi8fZETJXxvYZcJr48d https://cassyni.com/events/CKuKi8fZETJXxvYZcJr48d/abstract https://cassyni-user-files-prod.s3.amazonaws.com/ENg3pd8gzAyLGxuiy8DzvA https://cassyni.com/events/CKuKi8fZETJXxvYZcJr48d?videoPreview=1 Recombination and Speciation in the Annual Sunflowersnohttps://cassyni.com/events/CKuKi8fZETJXxvYZcJr48d?videoPreview=12024-06-06T13:15:00+00:002103.12New Phytologist Foundation In sexual species, recombination is considered to be the greatest impediment to speciation. The main problem with recombination is that although divergent selection favors the buildup of associations between alleles favored in local environments and those causing reproductive isolation, gene flow and recombination break the associations apart. However, examples of speciation in the face of gene flow began accumulating in the late 20th century, with accelerating evidence over the past two decades. How can this happen? In my talk, I will attempt to answer this question, drawing on a series of investigations of wild sunflower species, ranging from genome-wide association studies of phenotypic variation to field-based analyses of reproductive barrier strength, to functional characterization of candidate genes underlying reproductive isolation. I will show that most of the traits and genes that contribute to local adaptation and reproduction isolation in wild sunflowers are associated with chromosomal inversions or other recombination suppressors, thereby resolving the antagonism between selection and recombination. This genetic architecture appears to be common in other organisms, and thus offers a general solution for how speciation can occur in the presence of gene flow.https://cassyni-user-files-prod.s3.amazonaws.com/ENg3pd8gzAyLGxuiy8DzvA https://cassyni.com/slides/outline/NhYdo7mTrRrgduY6uyjPSm https://cassyni.com/events/NhYdo7mTrRrgduY6uyjPSm/abstract https://cassyni-user-files-prod.s3.amazonaws.com/UwoNgnifwBJAvtMK5PBohg https://cassyni.com/events/NhYdo7mTrRrgduY6uyjPSm?videoPreview=1 Auxin dynamics and symmetry breaking in Mimulus floral meristemnohttps://cassyni.com/events/NhYdo7mTrRrgduY6uyjPSm?videoPreview=12024-06-07T16:15:00+00:001036.08New Phytologist Foundation Bilaterally symmetric flowers exhibit only one plane of symmetry along the dorsal-ventral (D-V) axis and is one of the most common floral forms. The developmental programs governing differential organ elaboration along the D-V axis in many taxa have been known since the early 1990s, but how are the D-V domains specified at the earliest stage of the floral meristem (FM) remains elusive. Previous studies indicated that auxin dynamic is crucial for D-V domain establishment, while the mechanism of which is unknown. Using the monkey flower species Mimulus parishii as a model system, we conducted quantitative high-resolution live-imaging of auxin-maxima reporter DR5 in both wild-type and transgenic mutants with either dorsalized or ventralized flowers. We observed striking auxin dynamics during the earliest developmental stages of the FM, during which the auxin maxima first appear at the center of the FM, then move to the dorsal most region, and subsequently the D-V domains are separated by a band of auxin depletion zone. Our results provide the first line of evidence of how the spatiotemporal dynamics of auxin can be associated with the symmetry-breaking mechanism in the FM and the putative genes controlling this process.https://cassyni-user-files-prod.s3.amazonaws.com/UwoNgnifwBJAvtMK5PBohg https://cassyni.com/events/2wcTwmtUJ7i2vsY3trCfAu/abstract https://cassyni-user-files-prod.s3.amazonaws.com/wqpkHh5nkYAnjwZSRZ64W https://cassyni.com/slides/outline/Doskxp81xBtWT9N5WPSM7j https://cassyni.com/events/Doskxp81xBtWT9N5WPSM7j/abstract https://cassyni-user-files-prod.s3.amazonaws.com/ANhVdxR2mCYxvKYb2X5GZc https://cassyni.com/events/Doskxp81xBtWT9N5WPSM7j?videoPreview=1 What Is Boolean Valued Analysis?nohttps://cassyni.com/events/Doskxp81xBtWT9N5WPSM7j?videoPreview=12021-03-18T14:00:00+00:003070.48Positivity Journal, SpringerNatureThis is a slightly informal invitation to Boolean valued analysis. We will discuss the three questions: Why should we know anything at all about Boolean valued analysis? What need the working mathematician know this for? What do the Boolean valued models yield?https://cassyni-user-files-prod.s3.amazonaws.com/ANhVdxR2mCYxvKYb2X5GZc https://cassyni.com/events/CpaYsSpy5GnMnPY5QQy2Jq/abstract https://cassyni-user-files-prod.s3.amazonaws.com/BGfVSYjgimkqNskEqPrCKx https://cassyni.com/slides/outline/6QBKPBw2mgWSnGJEkBQncd https://cassyni.com/events/6QBKPBw2mgWSnGJEkBQncd/abstract https://cassyni-user-files-prod.s3.amazonaws.com/NwReoG5zRxy5a31Hun4UES https://cassyni.com/events/6QBKPBw2mgWSnGJEkBQncd?videoPreview=1 Rare transmission of commensal and pathogenic bacteria in the gut microbiome of hospitalized adultsnohttps://cassyni.com/events/6QBKPBw2mgWSnGJEkBQncd?videoPreview=12021-10-14T11:00:00+00:00682.24Microbiome Virtual International Forum Bacterial bloodstream infections are a major cause of morbidity and mortality among patients undergoing hematopoietic cell transplantation (HCT). Although previous research has demonstrated that pathogenic organisms may translocate from the gut microbiome into the bloodstream to cause infections, the mechanisms by which HCT patients acquire pathogens in their microbiome have not yet been described. We hypothesized that patient-patient transmission may be responsible for pathogens colonizing the microbiome of HCT patients, and that patients who share time and space in the hospital are more likely to share bacterial strains. Here, we used linked-read and short-read metagenomic sequencing to analyze 401 stool samples collected from 149 adults undergoing HCT and hospitalized in the same unit over a period of three years. We used metagenomic assembly and strain-specific comparison methods to investigate transmission of gut microbiota between individuals. While transmission of pathogens was found to be rare, we did observe four pairs of patients who harbor identical or nearly identical E. faecium strains in their microbiome. These strains may be the result of transmission between patients who shared a room and bathroom, acquisition from a common source in the hospital or transmission from an unsampled source. We also observed identical Akkermansia muciniphila and Hungatella hathewayi strains in two pairs of patients. In both cases, the patients were roommates for at least one day, the strain was absent in the putative recipient’s microbiome prior to the period of roommate overlap and the putative recipient had a microbiome perturbed by antibiotic treatment for a bloodstream infection. Finally, we identified multiple patients who acquired identical strains of several species commonly found in commercial probiotics and dairy products, including Lactobacillus rhamnosus, Lactobacillus gasseri and Streptococcus thermophilus. Overall, the limited amount of putative transmission observed indicates that current infection control and contact precautions are successful in preventing interpersonal exchange of microbes. However, the potential transmission of commensal microbes with immunomodulatory properties raises interesting questions about the recovery of microbiome diversity after HCT, and indicates that patients in this setting may acquire new microbes by sharing space with others.https://cassyni-user-files-prod.s3.amazonaws.com/NwReoG5zRxy5a31Hun4UES https://cassyni.com/slides/outline/8sRLccAexyGw9CmoHsKRLZ https://cassyni.com/events/8sRLccAexyGw9CmoHsKRLZ/abstract https://cassyni-user-files-prod.s3.amazonaws.com/K7QDgxpg2fgKcNyAxruPWe https://cassyni.com/events/8sRLccAexyGw9CmoHsKRLZ?videoPreview=1 Genetic Diversity of the Chlorhexidine Resistance in Cultivable Bacteria Isolated from a Medical Intensive Care Unit Environmentnohttps://cassyni.com/events/8sRLccAexyGw9CmoHsKRLZ?videoPreview=12021-12-08T15:00:00+00:0057.52Microbiome Virtual International Forum The emergence of resistance to biocides is a critical concern in healthcare settings, severely limiting our ability to prevent infection. Chlorhexidine is one of the most widely used disinfectants in the medical intensive care units (MICU) since the 1950s . It is usually applied onto the skin of the patients and health care providers and acts against a wide range of bacteria by disrupting the cell membrane of the bacterial cell wall. However, studies have shown that the exposure to sub-lethal chlorhexidine concentrations may enhance resistance in species well known for emerging antibiotic resistance . To understand the genomic diversity of chlorhexidine tolerance in a high-priority environment, we surveyed an MICU for cultivable organisms demonstrating chlorhexidine resistance and performed whole genome sequencing on selected isolates. We collected 219 swab samples from different locations (e.g. nurse calls, keyboards, bed rails, etc) over two sampling events. The samples were then subjected to cultivation, morphological characterization and selective media screening, resulting in 1415 isolates, of which 308 isolates (21.8%) were able to grow on agar containing 18.75 µg/mL chlorhexidine digluconate. We take a comparative genomics approach to identifying genes related to chlorhexidine resistance by comparing genomes of the same species with different chlorhexidine susceptibility. Future work will focus on testing cross-resistance between chlorhexidine and clinically relevant antibiotics in the collected isolates. As the hospital microbiome can serve as a source of antibiotic-resistant bacteria, contributing to hospital-acquired infections, the genetic characterization of chlorhexidine-resistant organisms at environmental locations within the MICU has important implications for disinfection and patient safety, as well as advancing our basic understanding of resistance to this widely used disinfectant.https://cassyni-user-files-prod.s3.amazonaws.com/K7QDgxpg2fgKcNyAxruPWe https://cassyni.com/slides/outline/ThGvMTnP6yRPAatjhhntV https://cassyni.com/events/ThGvMTnP6yRPAatjhhntV/abstract https://cassyni-user-files-prod.s3.amazonaws.com/FnAWCVnK5dafUEnkyw23Gi https://cassyni.com/events/ThGvMTnP6yRPAatjhhntV?videoPreview=1 Using strain-resolved analysis to identify contamination in metagenomics datanohttps://cassyni.com/events/ThGvMTnP6yRPAatjhhntV?videoPreview=12022-02-08T12:00:00+00:00588.0Microbiome Virtual International Forum Metagenomics analyses can be negatively impacted by DNA contamination. While external sources of contamination such as DNA extraction kits have been widely reported and investigated, contamination originating within the study itself remains underreported. Here we applied high-resolution strain-resolved analyses to identify contamination in two large-scale clinical metagenomics datasets. By mapping strain sharing to DNA extraction plates, we identified well-to-well contamination in both negative controls and biological samples in one dataset. Such contamination is more likely to occur among samples that are on the same or adjacent columns or rows of the extraction plate than samples that are far apart. Our strain-resolved workflow also reveals the presence of externally derived contamination, primarily in the other dataset. Overall in both datasets, contamination is more significant in samples with lower biomass. Our work demonstrates that genome-resolved strain tracking, with its essentially genome-wide nucleotide-level resolution, can be used to detect contamination in sequencing-based microbiome studies. Our results underscore the value of strain-specific methods to detect contamination and the critical importance of looking for contamination beyond negative and positive controls.https://cassyni-user-files-prod.s3.amazonaws.com/FnAWCVnK5dafUEnkyw23Gi https://cassyni.com/slides/outline/3vwJ9mhQaPjuk74THPcRcR https://cassyni.com/events/3vwJ9mhQaPjuk74THPcRcR/abstract https://cassyni-user-files-prod.s3.amazonaws.com/XDQ1nEEaPpwzaZAesTMDrN https://cassyni.com/events/3vwJ9mhQaPjuk74THPcRcR?videoPreview=1 Maternal metformin treatment persistently ameliorates high-fat diet-induced metabolic symptoms and modulates gut microbiota in rat offspringnohttps://cassyni.com/events/3vwJ9mhQaPjuk74THPcRcR?videoPreview=12022-05-10T13:00:00+00:0069.6Microbiome Virtual International Forum Background: Maternal high-fat (HF) diet has long-term deleterious effect on offspring’s metabolic phenotype. The aim of this study was to evaluate whether maternal metformin (MT) administration ameliorates the negative effects of maternal HF diet on offspring and the role of gut microbiota and microbial bile acids (BAs) in it. Methods: After mating, the pregnant Sprague-Dawley rats were randomly assigned to HF diet (60% fat) or standard CHOW diet (11.8% fat) group, and some of the HF diet group rats were co-treated with MT via drinking water (300 mg/kg/day), resulting in three groups according to maternal diet and MT treatment during gestation and lactation. All offspring were weaned on CHOW diet. The intestinal tissues and colon content of offspring rats were collected. In addition, offspring’s hypothalamus gene expression and BA content in plasma of adult male offspring was analyzed. Results: Maternal HF diet resulted in increased body weight and adipose depots, increased intestinal and hypothalamic inflammation, changed gene expression of intestinal tight junctions and hypothalamic appetite markers in both male and female offspring at weaning, which continued into adulthood. The effects of maternal HF diet on offspring were alleviated by maternal MT administration. Interestingly, offspring’s microbiota composition in adulthood was profoundly influenced by maternal HF diet and MT administration. Furthermore, the plasma BA content was normalized by maternal MT administration in adult male offspring of HF-fed dams, and maternal MT administration significantly enriched the proportion of the beneficial Lactobacillus genera, which were negatively correlated with plasma unconjugated BA levels. Conclusions: This study demonstrated the beneficial effects of maternal MT administration on offspring’s metabolic phenotype, focusing on the microbiota-BA-hypothalamus axis. The present study indicates that maternal MT administration could reshape the gut microbiota in adult offspring, normalize offspring’s plasma BA levels and gene expression of hypothalamic appetite markers, which may contribute to the beneficial effects of maternal MT exposure on offspring’s metabolic phenotype.https://cassyni-user-files-prod.s3.amazonaws.com/XDQ1nEEaPpwzaZAesTMDrN https://cassyni.com/slides/outline/Ar1koLkkioVhEv42eqBMm7 https://cassyni.com/events/Ar1koLkkioVhEv42eqBMm7/abstract https://cassyni-user-files-prod.s3.amazonaws.com/MakjNu7qqQ9iZXpBcfB7zE https://cassyni.com/events/Ar1koLkkioVhEv42eqBMm7?videoPreview=1 Maternal and foetal outcomes among pregnant women with vaginal dysbiosis: a systematic review and meta-analysisnohttps://cassyni.com/events/Ar1koLkkioVhEv42eqBMm7?videoPreview=12022-11-08T15:00:00+00:00640.04Microbiome Virtual International Forum Bacterial vaginosis (BV) is the most common gynecological condition in women of reproductive age. BV affects women during pregnancy and could lead to maternal-foetal outcomes that can be fatal for mothers and newborns. The aim of this review is to identify the different maternal and foetal outcomes among pregnant women with BV encountered worldwide and to highlight their prevalence. We search worldwide published articles that have recorded the prevalence of maternal-foetal outcomes among pregnant women with BV in the database Embase, PubMed, Web of Science, and Global Index Medicus from inception until January 2022. The meta-analysis was performed using a random-effects model. Sources of heterogeneity were investigated using subgroup analysis, while funnel plots and Egger tests were performed to assess publication bias. This review was registered in PROSPERO with the number CRD42022299498. A total of 8254 articles were found in the searched databases. After the exclusion of duplicated articles and others for multiple reasons, we finally obtained 26 articles that met all inclusion criteria. Worldwide, we recorded separately 22 maternal outcomes and 22 foetal outcomes among pregnant women with BV. When analyzing the different worldwide outcomes combined, there are 5 maternal-fetal outcomes that have been reported with the highest prevalence namely preterm birth, before 37 wGA (17.9% [95%CI= 13-23.3]), mechanical ventilation (15.2% [95%CI= 0-45.9]), low birth weight, less than 2500 g (14.2% [95%CI= 9.1-20.1]), premature rupture of membrane, before 37 wGA (13.2% [95%CI= 6.1-22.3]) and neonatal intensive care unit admission (11.2 % [95%CI= 0-53.5]). We also found that at the level of the WHO Region, South-East Asia records the highest prevalence of maternal-foetal outcomes (25.5 % [95%CI = 17.5-34.4]) followed by Africa with a prevalence of (24.6% [95%CI= 16.8-33.4]). At the diagnostic level, we obtained the greatest prevalence (37.2% [95%CI= 23-52.6]) for BV diagnosed with Amsel criteria, then blue test (31.7 % [95%CI= 8.4-60.6]). When considering gestation age, we obtained a high prevalence (29.6% [95%CI= 21.2-38.8]) among pregnant women with BV diagnosed in the third trimester of pregnancy. Even if BV is one of the most common vaginal conditions, the repartition of the type of maternal-foetal outcomes among pregnant women positive for BV is grandly disproportional among countries and continents.https://cassyni-user-files-prod.s3.amazonaws.com/MakjNu7qqQ9iZXpBcfB7zE https://cassyni.com/slides/outline/JFmScDyWi2jFsyGtuGyXoj https://cassyni.com/events/JFmScDyWi2jFsyGtuGyXoj/abstract https://cassyni-user-files-prod.s3.amazonaws.com/975NhiN6Kczd8GCPnqydfL https://cassyni.com/events/JFmScDyWi2jFsyGtuGyXoj?videoPreview=1 Probing the Metatranscriptome of the House Mosquito Culex tritaeniorhynchus from the Philippinesnohttps://cassyni.com/events/JFmScDyWi2jFsyGtuGyXoj?videoPreview=12023-10-17T10:00:00+00:0064.88Microbiome Virtual International Forum Culex tritaeniorhynchus is a common household mosquito vector for arboviruses and filarial parasites. To circumvent the development of insecticide resistance, untargeted metatranscriptomics approaches in studying local Culex microbiomes can unveil potential paratransgenic vectors and critical host-microbiome interaction gene targets, serving as foundations for alternative vector biosurveillance and control methods. The metatranscriptomes generated from house mosquitoes collected from Barangays Bayog and Lalakay, Los Baños, Laguna, were pre-processed and host-filtered via fastp, bowtie2, and OpenContami. The clean dscDNA reads were then pooled per barangay and assembled using Trinity and metaSPAdes. Bacterial metatranscripts were retrieved for blastx annotation against the UniProt database, GO and KEGG analysis, and STRING protein-protein interaction network generation. Gram-negative bacterial genera Escherichia, Shigella, and Pseudomonas traceable to the local aquatic and human microflora chiefly contributed to the abundance of transcripts involved in antimicrobial resistance, secondary metabolite transport, aromatic amino acid biosynthesis, cell wall organization, genome regulation, two-component signaling, and iron cofactor metabolism. Eight candidate prokaryotic genes were selected based on relative abundance and relevance to virulence, xenobiotic metabolism, and other adaptive functions. In both barangays and in select individual mosquitoes, all eight candidate genes were validated via RT-qPCR, exhibiting a wide range of Ct values and melt curve profiles. Genes involved in sustained survival against mosquito innate immune processes (enolases, peptidases, LPS remodelers) posit key players essential for the fitness of a potential paratransgenic vector. Individual variation in RT-qPCR detection results may hint at the relationship between the local and internal environments with respect to Culex microbiomes. As a pioneering metatranscriptomics study in the Philippines, we present potentially culturable paratransgenic vectors for Culex vector control, molecular mechanisms relevant to Culex-microbiome “interactomics”, and the role of environments in mediating the virulence of Culex parasites and symbionts. Recommendations include bacterial mRNA-enriched extraction protocols, in silico workflow integration with meta-omics datasets, and in vitro validation of culturable bacterial symbionts and their respective genes relevant for vector control.https://cassyni-user-files-prod.s3.amazonaws.com/975NhiN6Kczd8GCPnqydfL https://cassyni.com/slides/outline/Lj1TqeD8uKVkEukTSxtAXf https://cassyni.com/events/Lj1TqeD8uKVkEukTSxtAXf/abstract https://cassyni-user-files-prod.s3.amazonaws.com/J9m2WweJLu3LmmLxXXiB58 https://cassyni.com/events/Lj1TqeD8uKVkEukTSxtAXf?videoPreview=1 Metabolic diversity in commensal protists regulates intestinal immunity and trans-kingdom competitionnohttps://cassyni.com/events/Lj1TqeD8uKVkEukTSxtAXf?videoPreview=12023-12-19T14:00:00+00:00629.0Microbiome Virtual International Forum Commensal protists have historically been overlooked as members of the gut microbiota, but recent studies have highlighted the dominant effects of these commensals on the gut ecosystem. In particular, protists in the Parabasalia phylum reshape the intestinal immune landscape and influence host susceptibility to both infectious and inflammatory diseases. However, the mechanisms used by these protists to shape the gut environment remain poorly understood. Here, we identify a new species of commensal parabasalid in the mouse intestine, Tritrichomonas casperi. We find that metabolic differences between T. casperi and the closely related species Tritrichomonas musculis modulate their effects on host immunity and determine their ecological niche within the microbiota. First, we investigate metabolic output of these commensal parabasalids using genomic and metabolomic analysis. This reveals species-level differences in excretion of the tuft cell activating metabolite succinate, which causes differential remodeling of the immune system in the small intestine. Next, we investigate protist metabolic input by manipulating dietary fiber intake, as well as developing in vitro culture. This reveals that whereas T. musculis preferentially relies on dietary polysaccharides, T. casperi uses host mucus glycans as a carbon source. These carbon source preferences lead to differential competition with commensal bacteria in the intestine, including Bacteroidales spp. and Akkermansia muciniphila. These trans-kingdom interactions can in turn suppress protist-induced intestinal immune responses in a diet-dependent manner. Finally, we explore the diversity of commensal protists in humans by examining parabasalids in the microbiomes of both industrialized and non-industrialized populations. We identify multiple new species of commensal parabasalids in the microbiomes of non-industrialized populations, including novel human-associated tritrichomonads that are closely related T. musculis and T. casperi. Altogether, our findings elucidate how commensal parabasalid metabolism acts as a focal point for complex interactions with the host immune system, commensal bacteria, and diet, to impact intestinal immunity and host health. Link to OA paper: https://www.biorxiv.org/content/10.1101/2022.08.26.505490v2https://cassyni-user-files-prod.s3.amazonaws.com/J9m2WweJLu3LmmLxXXiB58 https://cassyni.com/slides/outline/V82jdGD4N6ujQF6vWpDDkZ https://cassyni.com/events/V82jdGD4N6ujQF6vWpDDkZ/abstract https://cassyni-user-files-prod.s3.amazonaws.com/LbTXHXpnxV3ZtmzBWghoBL https://cassyni.com/events/V82jdGD4N6ujQF6vWpDDkZ?videoPreview=1 Co-diversification of an intestinal Mycoplasma and its salmonid hostnohttps://cassyni.com/events/V82jdGD4N6ujQF6vWpDDkZ?videoPreview=12023-05-17T10:00:00+00:0058.6Microbiome Virtual International Forum Understanding the evolutionary relationships between a host and its intestinal resident bacteria can transform how we understand adaptive phenotypic traits. The interplay between hosts and their resident bacteria inevitably affects the intestinal environment and, thereby, the living conditions of both the host and the microbiota. Thereby this co-existence likely influences the fitness of both bacteria and host. Whether this co-existence leads to evolutionary co-diversification in animals is largely unexplored, mainly due to the complexity of the environment and microbial communities and the often low host selection. We present the gut metagenome from wild Atlantic salmon (Salmo salar), a new wild organism model with an intestinal microbiota of low complexity and a well-described population structure, making it well-suited for investigating co-evolution. Our data reveal a strong host selection of a core gut microbiota dominated by a single Mycoplasma species. We found a clear co-diversification between the population structure of Atlantic salmon and nucleotide variability of the intestinal Mycoplasma populations conforming to expectations from co-evolution between host and resident bacteria. Our results show that the stable microbiota of Atlantic salmon has evolved with its salmonid host populations while potentially providing adaptive traits to the salmon host populations, including defence mechanisms, biosynthesis of essential amino acids, and metabolism of B vitamins. We highlight Atlantic salmon as a novel model for studying co-evolution between vertebrate hosts and their resident bacteria. Link to OA paper: https://www.nature.com/articles/s41396-023-01379-zhttps://cassyni-user-files-prod.s3.amazonaws.com/LbTXHXpnxV3ZtmzBWghoBL https://cassyni.com/slides/outline/XbGkrgSgZPgDmBaV4W7rUV https://cassyni.com/events/XbGkrgSgZPgDmBaV4W7rUV/abstract https://cassyni-user-files-prod.s3.amazonaws.com/XmNU6F6CZjQ6Z2V5Hwdjb4 https://cassyni.com/events/XbGkrgSgZPgDmBaV4W7rUV?videoPreview=1 Particles floating on turbulent waternohttps://cassyni.com/events/XbGkrgSgZPgDmBaV4W7rUV?videoPreview=12024-05-29T09:00:00+00:003516.04Department of Aeronautics and AstronauticsEvery year, millions of tons of plastics enter the ocean. Devising effective strategies to mitigate such pollution requires the quantitative understanding of how floating particles travel and spread in turbulent waters. Past studies have mostly focused on the influence exerted by the surface on the flow underneath, while the characterization of the transport along the surface remains incomplete. I will summarize our recent experiments using laboratory and field-scale facilities. Microscopic particles faithfully follow the free surface flow, revealing a rich structure that shares similarities with both three-dimensional and two-dimensional turbulence, as well as unique features. In particular, due to the compressibility of the surface velocity field, the particles cluster over a wide range of spatial and temporal scales. For millimetre-sized particles, capillarity-driven attraction breaks the equilibrium between cluster formation and breakup, leading to aggregates that grow steadily in size. Even larger particles filter the small-scale velocity fluctuations, which results in a more time-correlated motion and, in turn, faster dispersion.https://cassyni-user-files-prod.s3.amazonaws.com/XmNU6F6CZjQ6Z2V5Hwdjb4 https://cassyni.com/events/U8jXXtv1VBoajVGvQqjtwf/abstract https://cassyni-user-files-prod.s3.amazonaws.com/EH5VVRCDr7iyU6Ve7PaE6a https://cassyni.com/slides/outline/VcQ7XehimxCZcTS2Ag1Kyw https://cassyni.com/events/VcQ7XehimxCZcTS2Ag1Kyw/abstract https://cassyni-user-files-prod.s3.amazonaws.com/JnTMZHDfQEGnCZYE94T2oG https://cassyni.com/events/VcQ7XehimxCZcTS2Ag1Kyw?videoPreview=1 Study on A Novel Nonlinear Vibration Feature-based Method for Fault Diagnosis in Ring-like Engineering Structuresnohttps://cassyni.com/events/VcQ7XehimxCZcTS2Ag1Kyw?videoPreview=12025-06-24T02:00:00+00:00515.52NODYSIn aerospace, mechanical, and civil engineering, ring-like structures such as satellite panels, pipes, and truss bridges often exhibit complex dynamic behaviors due to their closed-loop vibration paths. Traditional nonlinear vibration-based methods for diagnosing bolt-loosening faults in these structures face limitations like reliance on benchmark structures and neglect of nonlinear boundaries. To address this, a new method is proposed in this paper. It models the nonlinear dynamics of ring-like structures using a multi-degree-of-freedom (MDOF) system with nonlinear damper-spring connections, simulating bolt-loosening faults. By applying two harmonic excitations, local fault features are defined, leading to a fault diagnosis method. Simulations confirm the method's effectiveness in detecting single and multiple bolt-loosening faults.https://cassyni-user-files-prod.s3.amazonaws.com/JnTMZHDfQEGnCZYE94T2oG https://cassyni.com/slides/outline/S9rtCsB3hkKvam8TX1dNT7 https://cassyni.com/events/S9rtCsB3hkKvam8TX1dNT7/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Cys8Nst8eThj7GWoWLHx5k https://cassyni.com/events/S9rtCsB3hkKvam8TX1dNT7?videoPreview=1 Invariant Foliations for Data-Driven Reduced Order Modellingnohttps://cassyni.com/events/S9rtCsB3hkKvam8TX1dNT7?videoPreview=12025-06-24T10:00:00+00:00660.0NODYSInvariant foliations are the only mathematical structure that are guaranteed to produce both invariant and unique reduced order models from data. Following on from initial investigations, in this talk we demonstrate how invariant foliations are used to identify reduced order models about invariant tori in (quasi-) periodically forced systems. We show that invariant foliations both exist and unique under some non-resonance conditions for real analytic dynamical systems. The examples include video data from a forced clamped-clamped plate experiment, a traffic model and the vibrations of the London Millenium bridge under pedestrian flow.https://cassyni-user-files-prod.s3.amazonaws.com/Cys8Nst8eThj7GWoWLHx5k https://cassyni.com/slides/outline/Ud6uSHQfu36Qwhc24hY1B3 https://cassyni.com/events/Ud6uSHQfu36Qwhc24hY1B3/abstract https://cassyni-user-files-prod.s3.amazonaws.com/CEtiorQqzGsdH1LMf8QtYe https://cassyni.com/events/Ud6uSHQfu36Qwhc24hY1B3?videoPreview=1 Particle paths beneath nonlinear wavesnohttps://cassyni.com/events/Ud6uSHQfu36Qwhc24hY1B3?videoPreview=12025-06-24T11:00:00+00:00590.52NODYSWe explore particle trajectories within a two-dimensional flow of an ideal liquid, driven by the passage of a nonlinear gravity surface wave. These particle paths are described by solutions to a dynamical system. In a moving frame that follows a nonlinear traveling wave solution, the system becomes autonomous, allowing the particle paths to be expressed in Hamiltonian form. We provide a comprehensive analysis of the particle trajectories, considering the influence of a background flow in the fluid bulk. Additionally, we address the case of a conducting fluid, bounded above by a dielectric gas and influenced by normal electric fields.https://cassyni-user-files-prod.s3.amazonaws.com/CEtiorQqzGsdH1LMf8QtYe https://cassyni.com/slides/outline/5QdWGA11GX4fSmgBEti2Zb https://cassyni.com/events/5QdWGA11GX4fSmgBEti2Zb/abstract https://cassyni-user-files-prod.s3.amazonaws.com/EKnF5ZfA1m1GkAf7gqDujC https://cassyni.com/events/5QdWGA11GX4fSmgBEti2Zb?videoPreview=1 Poisson’s Ratio Control in Auxetic Metamaterials Under Large Tensile Strainsnohttps://cassyni.com/events/5QdWGA11GX4fSmgBEti2Zb?videoPreview=12025-06-24T11:00:00+00:00790.4NODYSAuxetic materials, known for their negative Poisson's ratios, offer enhanced mechanical properties like indentation resistance and energy absorption. However, maintaining a consistent Poisson's ratio under large strains is challenging due to geometric nonlinearities. This study introduces a data-driven framework for designing auxetic structures with programmable Poisson’s ratio behavior over large deformations. A parametric finite element (FE) model is developed using Abaqus, and a machine learning surrogate model is trained to predict Poisson's ratio based on geometric parameters within a 25% tensile strain range. An inverse design framework is established to optimize building block geometry for a target Poisson's ratio. Optimized 3D-printed specimens are tested, showing excellent agreement with predictions, validating the framework. This approach provides an efficient tool for designing auxetic materials with controlled Poisson's ratio behavior, enabling applications in soft robotics and morphing structures.https://cassyni-user-files-prod.s3.amazonaws.com/EKnF5ZfA1m1GkAf7gqDujC https://cassyni.com/slides/outline/DK2o7isHhCrKkpC9zsgj9o https://cassyni.com/events/DK2o7isHhCrKkpC9zsgj9o/abstract https://cassyni-user-files-prod.s3.amazonaws.com/XboEpj9iPUnEgtYSsben78 https://cassyni.com/events/DK2o7isHhCrKkpC9zsgj9o?videoPreview=1 Bayesian approaches to measurement and optimizationnohttps://cassyni.com/events/DK2o7isHhCrKkpC9zsgj9o?videoPreview=12025-06-12T15:00:00+00:002659.96Journal of Plasma PhysicsThis work explores the application of Bayesian methods to enhance measurement and optimization in experimental physics, with a focus on laser-plasma interactions. Bayesian updates enable the integration of prior knowledge with new data, facilitating refined parameter estimation and uncertainty quantification. These methods have been employed to achieve the first single-shot measurement of complete spatio-temporal vector fields, providing a comprehensive characterization of petawatt laser pulses. Additionally, Bayesian Autocorrelation Spectroscopy (BAS) is introduced as an innovative technique for spectral measurements, leveraging prior information for rapid convergence. Finally, Bayesian optimization demonstrates exceptional efficiency in tuning laser wakefield accelerators, enabling precise control over electron beam properties through systematic exploration of parameter space.https://cassyni-user-files-prod.s3.amazonaws.com/XboEpj9iPUnEgtYSsben78 https://cassyni.com/slides/outline/FnGpM96utVcp7kfiYZbMsj https://cassyni.com/events/FnGpM96utVcp7kfiYZbMsj/abstract https://cassyni-user-files-prod.s3.amazonaws.com/SQzPqYrhnAyFojhzSZ8yfk https://cassyni.com/events/FnGpM96utVcp7kfiYZbMsj?videoPreview=1 Shaping the Ion-Temperature-Gradient driven instability: a kinetic view on its localisationnohttps://cassyni.com/events/FnGpM96utVcp7kfiYZbMsj?videoPreview=12025-05-15T15:00:00+00:003413.6Journal of Plasma PhysicsIn a stellarator, the toroidal magnetic field can be shaped with a high degree of freedom, significantly influencing the behaviour of the confined plasma. Different aspects of plasma dynamics respond uniquely to these geometric variations, requiring a careful understanding of the underlying physics—often in regimes far from the well-studied tokamak case. In this talk, we examine how ion-temperature-gradient (ITG) driven instabilities respond to changes in magnetic geometry. Specifically, we analyse the linear kinetic response of ions, emphasizing the crucial role of localisation along the field line. We present a simple semi-analytical formula for the mode spectrum that captures key physical effects: long-wavelength Landau damping, ion-scale Larmor radius stabilisation, the weakening of Larmor radius effects at short wavelengths, and stabilisation due to magnetic-drift resonance. This model provides a clear qualitative framework for understanding typical stellarator linear gyrokinetic spectra, including the emergence of multiple maxima or transitions to extended modes, while acknowledging its limitations for precise quantitative predictions. These insights also inform a broader discussion on the trade-offs between ITG-driven turbulence and other phenomena such as MHD stability, offering new perspectives on stellarator optimisation.https://cassyni-user-files-prod.s3.amazonaws.com/SQzPqYrhnAyFojhzSZ8yfk https://cassyni.com/slides/outline/CKjb2MaEpHkB64N9tuDQLu https://cassyni.com/events/CKjb2MaEpHkB64N9tuDQLu/abstract https://cassyni-user-files-prod.s3.amazonaws.com/MEBYrNZhAs9pAPFJrVhtRc https://cassyni.com/events/CKjb2MaEpHkB64N9tuDQLu?videoPreview=1 Radiative Dynamics and Instabilities in Strongly Magnetized Relativistic Plasmasnohttps://cassyni.com/events/CKjb2MaEpHkB64N9tuDQLu?videoPreview=12024-11-07T16:00:00+00:002511.32Journal of Plasma PhysicsRadiative Dynamics and Instabilities in Strongly Magnetized Relativistic Plasmas Relativistic plasmas in strong electromagnetic fields exhibit distinct dynamics compared to classical plasmas, with radiative and quantum electrodynamical (QED) effects fundamentally altering their collective properties and dynamics. Here, we investigate strongly magnetized plasmas for which synchrotron cooling timescales are comparable to the collective dynamical timescales, causing particles to radiate their energy, and surprisingly part of their collective entropy. This radiative cooling drives the plasma out of kinetic equilibrium, triggering kinetic instabilities. Our theory and simulations show that strongly magnetized plasmas spontaneously generate coherent, linearly polarized radiation through the interplay between radiative cooling and the electron cyclotron maser instability. These findings showcase the unique dynamics that radiative mechanisms introduce in relativistic plasmas, offering key insights into environments with intense electromagnetic fields such as neutron stars and magnetars. With laboratory experiments now able to recreate these conditions, we propose potential experimental platforms to probe these dynamics and link theory with astrophysical observations.https://cassyni-user-files-prod.s3.amazonaws.com/MEBYrNZhAs9pAPFJrVhtRc https://cassyni.com/slides/outline/NhNu7Lg9SGJKm3MhCa6jf3 https://cassyni.com/events/NhNu7Lg9SGJKm3MhCa6jf3/abstract https://cassyni-user-files-prod.s3.amazonaws.com/UJQKbeF3eyWeaTnuUm9t5k https://cassyni.com/events/NhNu7Lg9SGJKm3MhCa6jf3?videoPreview=1 Testing cosmic ray acceleration in the laboratorynohttps://cassyni.com/events/NhNu7Lg9SGJKm3MhCa6jf3?videoPreview=12023-08-03T15:00:00+00:003537.84Journal of Plasma PhysicsPetawatt lasers can be used to recreate interesting astrophysical processes, e.g. amplification of magnetic fields by plasma turbulence generated in colliding laser-produced plasma flows. MHD instabilities in such turbulent, magnetized plasmas are seen to energise electrons above the thermal background, thus demonstrating an injection mechanism for cosmic ray acceleration. Ongoing experiments are studying whether stochastic acceleration by the Fermi process indeed occurs in such astrophysical environments, e.g. supernova remnants or the Galactic Fermi bubbles or radio galaxies.https://cassyni-user-files-prod.s3.amazonaws.com/UJQKbeF3eyWeaTnuUm9t5k https://cassyni.com/slides/outline/PC2WA2KfsirNkotao1PXvM https://cassyni.com/events/PC2WA2KfsirNkotao1PXvM/abstract https://cassyni-user-files-prod.s3.amazonaws.com/QC5B8USqocUSsXnCppgmyQ https://cassyni.com/events/PC2WA2KfsirNkotao1PXvM?videoPreview=1 Magnetospheric waves and bursts from magnetarsnohttps://cassyni.com/events/PC2WA2KfsirNkotao1PXvM?videoPreview=12022-12-15T16:00:00+00:003922.36Journal of Plasma PhysicsMagnetars are bursting neutron stars with ultrastrong magnetic fields. Their magnetospheric plasma is extreme in a few ways. Magnetic energy strongly dominates over the plasma rest mass, so magnetohydrodynamic (MHD) waves propagate with nearly speed of light. Dense (X-ray) radiation around the star strongly affects the plasma behavior -- photons create the plasma itself, and radiative processes generate a drag on particle motions. A canonical problem of magnetar physics is how the magnetospheric plasma responds to a kHz perturbation from a star quake. Observationally, such events are associated with powerful X-ray bursts, the main form of magnetar activity. Furthermore, this activity is linked to fast radio bursts of enormous strength. Magnetospheric perturbations responsible for these phenomena can be shear Alfvén waves or compressive (fast magnetosonic) waves. Both can be modeled from first principles, using relativistic MHD and kinetic descriptions. This work investigates the plasma response to the waves, how the waves energize particles and launch relativistic explosions, and how the accompanying radiative processes can produce powerful X-ray and radio emission. Similar physics may occur in binary neutron stars, generating quasi-periodic bursting activity before the binary merges.https://cassyni-user-files-prod.s3.amazonaws.com/QC5B8USqocUSsXnCppgmyQ https://cassyni.com/slides/outline/HktreWCu3gmJMweMC6Pjvu https://cassyni.com/events/HktreWCu3gmJMweMC6Pjvu/abstract https://cassyni-user-files-prod.s3.amazonaws.com/JkwXcxL4yaPNUfXyDugyyx https://cassyni.com/events/HktreWCu3gmJMweMC6Pjvu?videoPreview=1 Validation of low-Z impurity transport theory using boron perturbation experiments in ASDEX Upgradenohttps://cassyni.com/events/HktreWCu3gmJMweMC6Pjvu?videoPreview=12022-07-14T15:00:00+00:002843.64Journal of Plasma PhysicsImpurities are unavoidable in fusion plasmas and potentially problematic as they result in fuel dilution and radiative energy losses. Therefore, it is important to have accurate predictions of impurity behavior in future fusion devices, which requires a validated theoretical description of impurity transport. With this goal, an experimental technique was developed at ASDEX Upgrade (AUG) to separately identify the diffusive and convective components of the boron particle flux [1-2]. Using this technique, a database of B transport coefficients covering a wide range of plasma parameters has been assembled and can now be used to validate theoretical predictions of low-Z impurity transport [2]. This database shows that the normalized ion temperature gradient (R/L Ti ) is the strongest organizing parameter for both the B diffusion and convection and strong R/L Ti (>6) is a necessary ingredient to obtain hollow B density profiles in AUG. This database also shows that large changes in the applied neutral beam injection (NBI) have a relatively small impact on impurity transport compared to similar changes in electron cyclotron resonance heating (ECRH). Even low levels of ECRH power dramatically increase both the diffusive and convective fluxes and lead to peaking of the impurity density profile. Comparisons to a combination of neoclassical and quasi-linear gyrokinetic simulations show good agreement in the measured and predicted diffusion coefficients. The outward convection measured in NBI dominated plasmas, however, is not well captured by the simulations, despite the inclusion of fast ions [3]. In contrast, the convection is reasonably well reproduced for plasmas with flat or peaked boron density profiles. This dataset provides an excellent experimental validation of the non-monotonic, predicted, convective-particle-flux created by the combination of pure-pinch, thermodiffusion, and roto-diffusion. In addition, this dataset demonstrates a non-monotonic dependence of the experimental particle diffusivity to ion heat conductivity (D/χi) in qualitative agreement with theoretical predictions.https://cassyni-user-files-prod.s3.amazonaws.com/JkwXcxL4yaPNUfXyDugyyx https://cassyni.com/events/W76xobP228cAFctAASxU53/abstract https://cassyni.com/slides/outline/YaLz31ceDRNecZMii8s6ny https://cassyni.com/events/YaLz31ceDRNecZMii8s6ny/abstract https://cassyni-user-files-prod.s3.amazonaws.com/FRFrJR3XamU3JT7XuSTWT8 https://cassyni.com/events/YaLz31ceDRNecZMii8s6ny?videoPreview=1 Research on Complex/Dusty Plasmas in the Lab and in Spacenohttps://cassyni.com/events/YaLz31ceDRNecZMii8s6ny?videoPreview=12021-10-07T15:00:00+00:003063.2Journal of Plasma PhysicsComplex/dusty plasmas are plasmas containing small solid particles, which get charged by the collection of plasma electrons and ions. Due to their high charge in laboratory plasmas they start to interact strongly and can form liquid and solid structures, the latter is called plasma crystal. This can be seen as a classical condensed matter system where the main component – the solid particles – can be visualized and tracked dynamically. This allows investigations of fundamental processes in liquids and solids and their transitions. Solid particles of sizes of around a micrometer in diameter start to react strongly on gravity and levitating forces are mandatory. The sheath electric field of a rf-discharge allows the trapping of microparticles in the sheath and can be used to form 2-dimensional (horizontal) or compressed 3-dimensional (with a small extend in the vertical direction) complex plasma systems. To study large 3-dimensional complex plasmas in the bulk of a discharge microgravity experiments are necessary. PK-4 is the third plasma crystal facility on the International Space Station ISS continuing the successful research under microgravity conditions started in 2001 already. In this presentation I will give an overview on complex plasma research and will show recent results like active matter and electrorheological plasmas from ground based and ISS-based laboratories.https://cassyni-user-files-prod.s3.amazonaws.com/FRFrJR3XamU3JT7XuSTWT8 https://cassyni.com/events/RAcvLkumdZ58rXAp9yFULu/abstract https://cassyni-user-files-prod.s3.amazonaws.com/TomTCQCpAWULHVZynEbXve https://cassyni.com/events/TdrwaB9PpqqdDTeNhfA74q/abstract https://cassyni-user-files-prod.s3.amazonaws.com/ScpyxBtKpxfrAMExGgEyxr https://cassyni.com/events/8NaNmWuvhzEkSsbsnMZoNd/abstract https://cassyni.com/slides/outline/CoM9qk9yMQ2PKFoW6ZQFwK https://cassyni.com/events/CoM9qk9yMQ2PKFoW6ZQFwK/abstract https://cassyni-user-files-prod.s3.amazonaws.com/3xc2G76aqwXQPUtCR22uuG https://cassyni.com/events/CoM9qk9yMQ2PKFoW6ZQFwK?videoPreview=1 Clinical analysis of interventional sclerotherapy combined with oral sirolimus in the treatment of tongue lymphatic malformationsnohttps://cassyni.com/events/CoM9qk9yMQ2PKFoW6ZQFwK?videoPreview=12025-10-15T09:43:20+00:00759.2Society for Pediatric Interventional Radiology## Introduction To assess the clinical efficacy and safety of interventional sclerotherapy combined with oral sirolimus in treating tongue lymphatic malformation in children. ## Materials and Methods This is a retrospective study at a single center that collected the clinical data of 32 children (16 males and 16 females) diagnosed with lymphatic malformation of the tongue between October 2015 and July 2024. The lesions were distributed to the tongue body (n=28), tongue root (n=3), and mixed (n=1). Most cases of this condition happen before a child turns one year old (n=21). The treatment included simple interventional sclerotherapy (n=16) and interventional sclerotherapy combined with oral sirolimus treatment (n=16). Efficacy was evaluated as follows: mass regression ≥95%(cure); mass regression 50% to 95%(significant); mass regression 25% to 50% (moderate); mass regression <25% or deterioration (no response). ## Results In the group receiving the simple interventional sclerotherapy, 2 patients, 11 patients, and 2 patients were evaluated as cured, significant, and no response, respectively. Within the combined oral sirolimus group, 9 patients, 5 patients, and 1 patient were evaluated as cured, significant, and no response, respectively. Postoperative adverse reactions include: swelling (n=19); bleeding (n=1); tongue protrusion (n=1); partial necrosis of the tongue body (n=1). None of the patients experienced serious complications, such as ectopic embolisms, pulmonary hypertension, or severe allergic reactions. The follow-up period was from 6 months to 4 years. ## Discussion This study demonstrates that interventional sclerotherapy is a safe and effective treatment for tongue lymphatic malformations, and its efficacy may be enhanced when combined with sirolimus medication.https://cassyni-user-files-prod.s3.amazonaws.com/3xc2G76aqwXQPUtCR22uuG https://cassyni.com/events/V6VVLdsKDFxmKrhw4iKbSD/abstract https://cassyni-user-files-prod.s3.amazonaws.com/QnK1kuGpRwzddktsTjSB7L https://cassyni.com/slides/outline/X54HQjwXZjFRs2c8rTVvkm https://cassyni.com/events/X54HQjwXZjFRs2c8rTVvkm/abstract https://cassyni-user-files-prod.s3.amazonaws.com/2x7MdogdxDNqyqmQdR3gTp https://cassyni.com/events/X54HQjwXZjFRs2c8rTVvkm?videoPreview=1 Episode 12: A Conversation with David Gutmann and Yuan Pannohttps://cassyni.com/events/X54HQjwXZjFRs2c8rTVvkm?videoPreview=12026-02-19T09:00:00+00:002074.48Advanced ScienceNeurofibromatosis type 1 (NF1) is a cancer predisposition syndrome characterized by tumors intimately associated with the nervous system, presenting significant challenges in predicting disease progression and tailoring therapies. The profound clinical heterogeneity, where approximately 10% of individuals develop malignancies despite over 3000 known NF1 mutations, is a central research focus. Studies indicate that this variability stems from a complex interplay of germline mutations, environmental factors (e.g., microbiome, diet, exposome), and somatic “second-hit” mutations, with second-hit NF1 loss reported in normal-appearing postmortem patient tissues. Research indicates that diet can influence optic glioma tumorigenesis, and conditions such as asthma can modulate immune cell circuits that support tumor growth. Investigations reveal that NF1 mutations consistently lead to increased RAS activity, with the mTOR pathway also implicated. Analysis of mouse models with NF1 deletion in oligodendrocyte precursor cells (OPCs) demonstrates that these preneoplastic cells exhibit impaired response to neuronal activity and contribute to motor learning deficits. NF1 heterozygosity also results in OPC hyperintensities in the brain, resembling early preneoplastic lesions, for which spatial transcriptomics and single-cell phenotyping are considered vital tools for molecular elucidation. Tumor presentation in NF1 varies significantly with age and anatomical location; for instance, childhood optic pathway gliomas exhibit different cells of origin and clinical biology compared to adult manifestations. The temporal course of cognitive-behavioral problems and tumor development also differs. Future directions emphasize developing multi-modal risk assessment strategies that integrate genetic, laboratory, and phenotypic data, including potential circulating biomarkers, to deconvolve contributing factors and address the disease's inherent complexity as a dynamic interplay of cellular circuits rather than a linear progression.https://cassyni-user-files-prod.s3.amazonaws.com/2x7MdogdxDNqyqmQdR3gTp https://cassyni.com/slides/outline/TdkT7f5rDQ8idrScXE1fmX https://cassyni.com/events/TdkT7f5rDQ8idrScXE1fmX/abstract https://cassyni-user-files-prod.s3.amazonaws.com/2MNgGmPMYswo2csmyjCoHp https://cassyni.com/events/TdkT7f5rDQ8idrScXE1fmX?videoPreview=1 Baryon Cycles in the Biggest Galaxiesnohttps://cassyni.com/events/TdkT7f5rDQ8idrScXE1fmX?videoPreview=12022-10-03T13:00:00+00:003188.44Physics ReportsThe universe’s biggest galaxies have both vast atmospheres and supermassive central black holes. We will discuss our recent Physics Reports article that reviews how those two components of a large galaxy couple and regulate the galaxy’s star formation rate. Models of interactions between a supermassive black hole and the large-scale atmosphere suggest that the energy released as cold gas clouds accrete onto the black hole suspends the atmosphere in a state that is marginally stable to formation of cold clouds. A growing body of observational evidence indicates that many massive galaxies, ranging from the huge central galaxies of galaxy clusters down to our own Milky Way, are close to that marginal state. The gas supply for star formation within a galaxy in such a marginal state is closely tied to the galaxy's central potential well, as traced by the central velocity dispersion of its stars. Those findings suggest that energy released during black-hole accretion shuts down star formation when the central potential well depth exceeds a critical value determined by the galaxy’s supernova heating rate.https://cassyni-user-files-prod.s3.amazonaws.com/2MNgGmPMYswo2csmyjCoHp https://cassyni.com/slides/outline/X5sLiztEFC7W9JUXqdbPt9 https://cassyni.com/events/X5sLiztEFC7W9JUXqdbPt9/abstract https://cassyni-user-files-prod.s3.amazonaws.com/6eUr2VSZqRuxV8NDN4CKen https://cassyni.com/events/X5sLiztEFC7W9JUXqdbPt9?videoPreview=1 Latent symmetries: An introductionnohttps://cassyni.com/events/X5sLiztEFC7W9JUXqdbPt9?videoPreview=12022-11-08T14:00:00+00:004996.4MetaMATIn this talk, I will give an introduction to the emerging topic of latent symmetries. A latent symmetry is in general not apparent from a geometric inspection of the system. Instead, it becomes visible after a suitable dimensional reduction: The so-called isospectral reduction, which is akin to an effective Hamiltonian. As I will show in this talk, latent symmetries can lead to very interesting phenomena, including the induction of local symmetries on the system’s eigenstates or even degeneracies in the eigenvalue spectrum. Their study thus allows to gain knowledge about the system’s structure that remains hidden from a direct observation. The concept is exemplified through several wave-physical examples.https://cassyni-user-files-prod.s3.amazonaws.com/6eUr2VSZqRuxV8NDN4CKen https://cassyni.com/slides/outline/DobXpWy9vadEzfyucYfG2h https://cassyni.com/events/DobXpWy9vadEzfyucYfG2h/abstract https://cassyni-user-files-prod.s3.amazonaws.com/PuQm5RuJBFRqv1DnUw94ii https://cassyni.com/events/DobXpWy9vadEzfyucYfG2h?videoPreview=1 Dynamics of Laminar Separation Bubbles on Airfoilsnohttps://cassyni.com/events/DobXpWy9vadEzfyucYfG2h?videoPreview=12022-09-13T14:00:00+00:003367.12Experiments in FluidsRecent advancements in small and medium scale wind turbines as well as unmanned aerial vehicles brought about an increased interest in airfoil operation at chord Reynolds numbers below about 500,000. Airfoil performance in this domain of Reynolds numbers differs significantly from that common to classical aerodynamics. In particular, a laminar boundary layer on the suction side of the airfoil often separates even at low angles of attack, which detrimentally affects airfoil performance. The severity of performance degradation depends significantly on separated shear layer development. The shear layer is inherently unstable and undergoes transition to turbulence downstream of separation, which can lead to flow reattachment and the formation of a separation bubble. The associated flow dynamics plays a key role in the overall flow development over the airfoil. The seminar will present an overview of recent experimental studies that aim to provide a holistic outlook on separation bubble dynamics and its response to forcing. Moderated by Professor Tropea, the webinar will be hosted at 7am PDT, 10am EDT, 3pm BST, 4pm CET, 7:30 IST, 10pm CST https://cassyni-user-files-prod.s3.amazonaws.com/PuQm5RuJBFRqv1DnUw94ii https://cassyni.com/slides/outline/LDc3hxegb7w2d2eWE6MhwK https://cassyni.com/events/LDc3hxegb7w2d2eWE6MhwK/abstract https://cassyni-user-files-prod.s3.amazonaws.com/9fRGifZUGHkkMd2gQexU2J https://cassyni.com/events/LDc3hxegb7w2d2eWE6MhwK?videoPreview=1 Drag reducing riblets on nektar++nohttps://cassyni.com/events/LDc3hxegb7w2d2eWE6MhwK?videoPreview=12022-09-15T09:00:00+00:001647.64NEKTAR++Riblets, inspired from the ribbed texture of shark-skins have the potential to reduce turbulent skin-friction drag. Riblets are attractive due to its nature as a passive flow control device which requires no energy input to alter the flow favourably. An optimally designed riblet can achieve a skin-friction drag reduction of up to ∼ 10%, which can be exploited in skin-friction dominant engineering applications (i.e planes, submarines). The performance of a riblet strongly depends on its size and cross-sectional shape. An optimal riblet has a groove-cross sectional length of l_g^+ ∼ 10.7 (l_g^+ = A_g h/ν, where, A g is the riblet’s groove cross-sectional area), while its dependence on its cross-sectional shape is not known and is worth exploring. Preliminary studies of drag reducing riblets are performed using direct numerical simulations on nektar++ due to its ability to discretise complex geometries while achieving spectral accuracy. In particular, a turbulent channel flow filled with riblets is discretised by a combination of Fourier modes and spectral/hp elements. A study on mesh dependency and the assosciated challenges will be presented in the workshop.https://cassyni-user-files-prod.s3.amazonaws.com/9fRGifZUGHkkMd2gQexU2J https://cassyni.com/events/YaEVaVZ6byfk2x9xXhifVf/abstract https://cassyni-user-files-prod.s3.amazonaws.com/9ZtAkNSKFbipFco1w2zD6N https://cassyni.com/slides/outline/8rh9eEmcVbC3LnfMs6uvvR https://cassyni.com/events/8rh9eEmcVbC3LnfMs6uvvR/abstract https://cassyni-user-files-prod.s3.amazonaws.com/VEiofUkUBbuW9DnMPiSD1x https://cassyni.com/events/8rh9eEmcVbC3LnfMs6uvvR?videoPreview=1 Bending waves in quasiperiodic beams and platesnohttps://cassyni.com/events/8rh9eEmcVbC3LnfMs6uvvR?videoPreview=12022-11-22T14:00:00+00:004195.96MetaMATFlexural waves in slender structures, beams or plates, take an important place in engineering applications since they are easily excited and play a dominant role for noise generation. The reduction of flexural motion is an old problem, be it for building materials, automotive applications, or precision instruments. The vast majority of metamaterial studies in the vibroacoustic domain is aiming at vibration reduction of one- and two-dimensional structures. Their models are very often based on the periodicity assumption, giving physical insights with minimal calculation power. However, nature shows us that materials without translational symmetry in their structure can give rise to exotic wave scattering behaviour, very similar to Bragg scattering but with different rotational symmetries leading to 5- and 10-fold diffraction patterns. At the same time, Penrose showed mathematically that planes can be filled with combinations of a limited number of polyhedra in a fully aperiodic way. Despite the absence of any translational periodicity, these structures are uniquely defined and have recognizable local rotational symmetries. They are therefore called quasicrystals. We present two examples of bending waves in quasicrystalline structures, both numerical and experimental. The first case shows unexpected low-frequency band gaps in beams with two periodic arrays of slits. The scattering of bending waves due to the aperiodic changes in bending stiffness results in interaction between the two periodic Bragg band gaps. The second example shows the formation of band gaps and localized modes in a quasicrystal plate dressed with scatterers in a Penrose pattern. Band gaps occur at lower frequencies than in a periodic array of scatterers with the same density, but is therefore less efficient. In both cases the structures showcase areas with low and high vibrational amplitudes, a fact that might be exploited to lead high energy concentrations away from critical points.https://cassyni-user-files-prod.s3.amazonaws.com/VEiofUkUBbuW9DnMPiSD1x https://cassyni.com/events/XaYZtK3e61bKxmU3djiN4M/seminar/qa https://cassyni.com/slides/outline/XaYZtK3e61bKxmU3djiN4M https://cassyni.com/events/XaYZtK3e61bKxmU3djiN4M/abstract https://cassyni-user-files-prod.s3.amazonaws.com/XwFbZGTsLkAxVWu4HakzvJ https://cassyni.com/events/Gm6SVodtvGyheqBLd5tdWd/seminar/qa https://cassyni.com/slides/outline/Gm6SVodtvGyheqBLd5tdWd https://cassyni.com/events/Gm6SVodtvGyheqBLd5tdWd/abstract https://cassyni-user-files-prod.s3.amazonaws.com/QdYSGz9ZapW8uoC8ZAep2r https://cassyni.com/events/Gm6SVodtvGyheqBLd5tdWd?videoPreview=1 12 Labours Seminar Series (Technology Platform 2): Clinical Workflowsnohttps://cassyni.com/events/Gm6SVodtvGyheqBLd5tdWd?videoPreview=12023-05-03T00:00:00+00:002790.44Auckland Bioengineering InstituteThis seminar will present our latest efforts towards developing a Physiome modelling platform for precision medicine. We are currently building this platform to integrate clinical data with computational physiology workflows to produce personalised digital twins of patients. We will describe how we will store data within the platform using a FAIR data management system and outline our plans for deploying the platform and connecting it to health IT systems. This includes efforts towards creating linked databases and a unified clinical data management plan that can be used by researchers in their ethics applications. These efforts aim to maximise the secondary use of data, which is essential for integrating workflows being developed by different research groups to create digital twins. We will also present documentation being developed to assist researchers in translating their computational physiology workflows via commercialisation pathways.https://cassyni-user-files-prod.s3.amazonaws.com/QdYSGz9ZapW8uoC8ZAep2r https://cassyni.com/events/xNW5fdCDvTFCdaQXopm4h/seminar/qa https://cassyni.com/slides/outline/xNW5fdCDvTFCdaQXopm4h https://cassyni.com/events/xNW5fdCDvTFCdaQXopm4h/abstract https://cassyni-user-files-prod.s3.amazonaws.com/4AKUndGS2QShpRX7XcEZH8 https://cassyni.com/events/xNW5fdCDvTFCdaQXopm4h?videoPreview=1 Implementing fundamental symmetries with passive meta-materialsnohttps://cassyni.com/events/xNW5fdCDvTFCdaQXopm4h?videoPreview=12024-12-17T14:00:00+00:004691.04MetaMATTime-reversal and particle-hole symmetries are fundamental for stabilizing the topological phases seen in the periodic table of topological insulators and superconductors. These symmetries can act anti-unitarily and square to minus the identity and, as such, are un-natural for system with classical degrees of freedom. In this talk, I will review a proposal on how to implement these symmetries exactly and over a large range of frequencies. I will also emphasize why is important to implement every entry in the classification table and I will review several applications enabled by the proposed theoretical framework.https://cassyni-user-files-prod.s3.amazonaws.com/4AKUndGS2QShpRX7XcEZH8 https://cassyni.com/events/GmpdUB2wPf4bTFHn3rJ7vm/seminar/qa https://cassyni.com/slides/outline/GmpdUB2wPf4bTFHn3rJ7vm https://cassyni.com/events/GmpdUB2wPf4bTFHn3rJ7vm/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Kj4hu1gBDM1NvjCeeWC4bQ https://cassyni.com/events/GmpdUB2wPf4bTFHn3rJ7vm?videoPreview=1 Generalised Lagrangian mean: formulation and computationnohttps://cassyni.com/events/GmpdUB2wPf4bTFHn3rJ7vm?videoPreview=12024-11-01T16:00:00+00:003873.48Journal of Fluid MechanicsMany fluid dynamical phenomena are the result of interactions between small-scale or high-frequency fluctuations – associated with waves or turbulence – and mean flows. Modelling these requires some form of averaging to obtain coarse-grained models in which the effect of fluctuations is parameterised. In this context, Lagrangian averaging, whereby averages are computed along fluid trajectories, has advantages over the more straightforward Eulerian averaging, mainly because it preserves the advective structure of the equations of motion. The theory of generalised Lagrangian mean (GLM) formulated by Andrews & McIntyre provides the basis for the derivation of convenient Lagrangian-averaged models. In this talk, I will introduce this theory and show how a geometric perspective helps its interpretation and generalisation. I will then discuss recently introduced numerical methods for the computation of (temporal) Lagrangian averages from numerical simulation data. These methods avoid the explicit tracking of particles, replacing it by the solution of partial different equations that can be carried out on-the-fly, in tandem with the simulation. https://cassyni-user-files-prod.s3.amazonaws.com/Kj4hu1gBDM1NvjCeeWC4bQ https://cassyni.com/events/5QwMX5fkhVFf4KvSLyeDjb/seminar/qa https://cassyni.com/slides/outline/5QwMX5fkhVFf4KvSLyeDjb https://cassyni.com/events/5QwMX5fkhVFf4KvSLyeDjb/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Wor7EAtoP1Eo5QZGk6qBkA https://cassyni.com/events/5QwMX5fkhVFf4KvSLyeDjb?videoPreview=1 Composites in Top End cycling eventsnohttps://cassyni.com/events/5QwMX5fkhVFf4KvSLyeDjb?videoPreview=12024-12-06T12:00:00+00:004043.32Department of AeronauticsCarbon fibre was proven to be the main contributor in increasing the performance of the racing bicycle, especially in the highest level of competition like the Olympic Games. To develop an Olympic gold medal winning bicycle frame, several different inputs are necessary. These range from anthropometric data, force and power measurements, material properties, aerodynamic simulations, available compatible components and many others. This lecture will look back on the successful development of the frame for the British Cycling team that culminated with the London Olympics. https://cassyni-user-files-prod.s3.amazonaws.com/Wor7EAtoP1Eo5QZGk6qBkA https://cassyni.com/events/4Re9RiNhpa9WPa6SF1Atvh/seminar/qa https://cassyni.com/slides/outline/4Re9RiNhpa9WPa6SF1Atvh https://cassyni.com/events/4Re9RiNhpa9WPa6SF1Atvh/abstract https://cassyni-user-files-prod.s3.amazonaws.com/DkWVeLrvmRsoEdZejZx3dQ https://cassyni.com/events/4Re9RiNhpa9WPa6SF1Atvh?videoPreview=1 Addressing psychosocial barriers to engaging in mental health care services for women across the lifespannohttps://cassyni.com/events/4Re9RiNhpa9WPa6SF1Atvh?videoPreview=12025-01-23T15:00:00+00:003346.44Women's HealthAddressing psychosocial barriers to engaging in mental health care services for women across the lifespan. Women have a higher prevalence of depressive symptoms and are more likely to be caregivers within their family systems and communities. This results in unique psychosocial stressors and burdens for women across the lifespan. The use of mental health services carries social stigma and those who need services from underserved and disadvantaged backgrounds often delay accessing these needed services. This special collection will place an emphasis on perspectives on mental health for women and the optimization of mental health services for women. There will be a special emphasis on the use of novel tools such as digital health or technology, the use of firsthand lived experience narratives or storytelling, and other innovations in optimizing engagement in mental health service engagement as well as general well being optimization for women’s health. Consideration for submissions that highlight unique barriers and perspectives affecting underserved women will be prioritized.https://cassyni-user-files-prod.s3.amazonaws.com/DkWVeLrvmRsoEdZejZx3dQ https://cassyni.com/events/EoFqQ4xj3Bmvv5PaG77ncD/seminar/qa https://cassyni.com/slides/outline/EoFqQ4xj3Bmvv5PaG77ncD https://cassyni.com/events/EoFqQ4xj3Bmvv5PaG77ncD/abstract https://cassyni-user-files-prod.s3.amazonaws.com/WFPFBVaZNLb48n1eLLXZU2 https://cassyni.com/events/EoFqQ4xj3Bmvv5PaG77ncD?videoPreview=1 Science-policy Interface Debatenohttps://cassyni.com/events/EoFqQ4xj3Bmvv5PaG77ncD?videoPreview=12025-01-22T09:00:00+00:003533.04Cambridge PrismsNo abstracthttps://cassyni-user-files-prod.s3.amazonaws.com/WFPFBVaZNLb48n1eLLXZU2 https://cassyni.com/slides/outline/Sy5wz4juitXakUTJwJJUM https://cassyni.com/events/Sy5wz4juitXakUTJwJJUM/abstract https://cassyni-user-files-prod.s3.amazonaws.com/U1f4JgKFkxB8rNFA3kh7wU https://cassyni.com/events/Sy5wz4juitXakUTJwJJUM?videoPreview=1 On the nature of intermittency in a turbulent von Kármán flownohttps://cassyni.com/events/Sy5wz4juitXakUTJwJJUM?videoPreview=12021-06-04T15:00:00+00:001692.0Journal of Fluid MechanicsWe have conducted an extensive study of the scaling properties of small scale turbulence using both numerical and experimental data of a flow in the same von Kármán geometry. We have computed the wavelet structure functions, and the structure functions of the vortical part of the flow and of the local energy transfers. We find that the latter obeys a generalized extended scaling, similar to that already observed for the wavelet structure functions. We compute the multi-fractal spectra of all the structure functions and show that they all coincide with each other, providing a local refined hypothesis. We find that both areas of strong vorticity and strong local energy transfer are highly intermittent and are correlated. For most cases, the location of local maximum of energy transfer is shifted with respect to the location of local maximum of vorticity. We however observe a much stronger correlation between vorticity and local energy transfer in the shear layer, that may be an indication of a self-similar quasi-singular structure that may dominate the scaling properties at large order structure functions.https://cassyni-user-files-prod.s3.amazonaws.com/U1f4JgKFkxB8rNFA3kh7wU https://cassyni.com/slides/outline/3vD7BQJN71f1wgx1rdCwCH https://cassyni.com/events/3vD7BQJN71f1wgx1rdCwCH/abstract https://cassyni-user-files-prod.s3.amazonaws.com/NaXQoACUvv5h3ju982ZVhp https://cassyni.com/events/3vD7BQJN71f1wgx1rdCwCH?videoPreview=1 Visco-elasticity of Foam Filmsnohttps://cassyni.com/events/3vD7BQJN71f1wgx1rdCwCH?videoPreview=12021-01-29T16:00:00+00:003719.84Journal of Fluid MechanicsLiquid foam exhibits surprisingly high viscosity, higher than each of its phases. This dissipation enhancement has been rationalized by invoking either a geometrical confinement of the shear in the liquid phase, or the influence of the interface viscosity. However, a precise localization of the dissipation, and its mechanism at the bubble scale, is still lacking. To this aim, we simultaneously monitored the evolution of the local flow velocity, film thickness and surface tension of a five films assembly, induced by different controlled deformations. These measurements allow us to build local constitutive relations for this foam elementary brick. We first show that, for our millimetric foam films, the main part of the film has a purely elastic, reversible behavior, thus ruling out the interface viscosity to explain the observed dissipation. We then highlight a generic frustration at the menisci, controlling the interface transfer between neighbor films and resulting in the localization of a bulk shear flow close to the menisci. A model accounting for surfactant transport in these small sheared regions is developed. It is in good agreement with the experiment, and demonstrate that most of the dissipation is localized in these domains. The length of these sheared regions, determined by the physico-chemical properties of the solution, sets a transition between a large bubble regime in which the films are mainly stretched and compressed, and a small bubble regime in which they are sheared. Finally, we discuss the parameter range where a model of foam viscosity could be built on the basis of these local results.https://cassyni-user-files-prod.s3.amazonaws.com/NaXQoACUvv5h3ju982ZVhp https://cassyni.com/slides/outline/GGRDLVUV5TVsqNBppymfLR https://cassyni.com/events/GGRDLVUV5TVsqNBppymfLR/abstract https://cassyni-user-files-prod.s3.amazonaws.com/oPydARNBVABJGVKE9JT6E https://cassyni.com/slides/outline/AqHZpyMiFRQoSVwbE4msLy https://cassyni.com/events/AqHZpyMiFRQoSVwbE4msLy/abstract https://cassyni-user-files-prod.s3.amazonaws.com/HiidxzDRsvZ58WK56ezfTC https://cassyni.com/events/AqHZpyMiFRQoSVwbE4msLy?videoPreview=1 Interaction of acoustic waves and shelled microbubbles/droplets for sensing applicationnohttps://cassyni.com/events/AqHZpyMiFRQoSVwbE4msLy?videoPreview=12022-07-07T08:50:00+00:001151.04ETOPIMIn the field of microfluidic, microbubbles and microdroplets are studied for many applications. For instance, microbubbles are used as Ultrasound Contrast Agent (UCA) to enhance the acoustic contrast of the human blood pool during an echography, and microdroplets are mainly used as reaction chambers, leading to the development of digital microfluidics. In this project, we propose to use the surface of microbubbles and droplets for acoustic sensing application. This presentation will be focused on simulations performed to study the interaction between the acoustic wave and the microbubbles-droplets, in order to detect the capture of analytes on their surface.https://cassyni-user-files-prod.s3.amazonaws.com/HiidxzDRsvZ58WK56ezfTC https://cassyni.com/slides/outline/BKwAsf1EgsxrSGUUpW4fcH https://cassyni.com/events/BKwAsf1EgsxrSGUUpW4fcH/abstract https://cassyni-user-files-prod.s3.amazonaws.com/2ewi48yvVTg8obaNUrrL86 https://cassyni.com/events/BKwAsf1EgsxrSGUUpW4fcH?videoPreview=1 Exotic Wave Phenomena in Time Metamaterialsnohttps://cassyni.com/events/BKwAsf1EgsxrSGUUpW4fcH?videoPreview=12022-07-08T12:00:00+00:002803.04ETOPIMIn this talk, I will discuss our group recent progress in exploring the exotic wave-matter interactions occurring at time interfaces, emerging when the material properties are abruptly switched in time, and in time metamaterials formed by suitable combinations of time interfaces. We discuss general energy considerations in the involved temporal scattering processes, with special emphasis on situations in which multiple waves are present in the materials, and the involved materials are non-Hermitian and/or nonlocal. We also discuss more complex scenarios in which the temporal switching is not abrupt, and the case of open resonators switched in time, enabling efficient phase conjugation and frequency conversion of the scattered fields.https://cassyni-user-files-prod.s3.amazonaws.com/2ewi48yvVTg8obaNUrrL86 https://cassyni.com/slides/outline/MhaUxe79JrX17FU28AwzvR https://cassyni.com/events/MhaUxe79JrX17FU28AwzvR/abstract https://cassyni-user-files-prod.s3.amazonaws.com/3Wyuu1D96wMJESq4W6YUfp https://cassyni.com/events/MhaUxe79JrX17FU28AwzvR?videoPreview=1 The Trial Effect in Patients with Glioblastoma: Effect of Clinical Trial Enrollment on Overall Survivalnohttps://cassyni.com/events/MhaUxe79JrX17FU28AwzvR?videoPreview=12022-10-03T20:00:00+00:001528.72Journal of Neuro-OncologyNo abstracthttps://cassyni-user-files-prod.s3.amazonaws.com/3Wyuu1D96wMJESq4W6YUfp https://cassyni.com/slides/outline/JF3FdraUEeeN5ZATUWa3Pb https://cassyni.com/events/JF3FdraUEeeN5ZATUWa3Pb/abstract https://cassyni-user-files-prod.s3.amazonaws.com/QRxRiishaPA4KSkp2nzUFG https://cassyni.com/events/JF3FdraUEeeN5ZATUWa3Pb?videoPreview=1 Mechanisms and Universality in the Subcritical Route to Turbulencenohttps://cassyni.com/events/JF3FdraUEeeN5ZATUWa3Pb?videoPreview=12020-06-12T15:00:00+00:003945.36Journal of Fluid MechanicsRecent years have witnessed a profound change in our understanding of the route to turbulence in wall-bounded shear flows. In stark contrast to the classical Hopf-Landau picture where turbulence arises through an increase in the temporal complexity of fluid motion, the route to turbulence in subcritical shear flows occurs via spatio-temporal intermittency and falls in the class of non-equilibrium statistical phase transitions known as directed percolation. In this talk I will focus on two aspects of the transition problem. The first is physical mechanisms underlying spatio-temporal intermittency in shear flows. The second is the universality in the subcritical route to turbulence.https://cassyni-user-files-prod.s3.amazonaws.com/QRxRiishaPA4KSkp2nzUFG https://cassyni.com/slides/outline/LiHGsGp6RwQrSVe22CUg7X https://cassyni.com/events/LiHGsGp6RwQrSVe22CUg7X/abstract https://cassyni-user-files-prod.s3.amazonaws.com/4bmpzfBLmM5RUxRDnBbxyc https://cassyni.com/events/LiHGsGp6RwQrSVe22CUg7X?videoPreview=1 The Limiting Absorption Principle and Continuity Properties of the Special Shift Function for Massless Dirac-Type Operatorsnohttps://cassyni.com/events/LiHGsGp6RwQrSVe22CUg7X?videoPreview=12022-05-06T17:10:00+00:002830.04Acta Scientiarum MathematicarumWe report on recent results regarding the limiting absorption principle for multi-dimensional, massless Dirac-type operators (implying absence of singularly continuous spectrum) and continuity properties of the associated spectral shift function. We will motivate our interest in this circle of ideas by briefly describing the connection to the notion of the Witten index for a certain class of non-Fredholm operators. This is based on various joint work with A. Carey, J. Kaad, G. Levitina, R. Nichols, D. Potapov, F. Sukochev, and D. Zanin.https://cassyni-user-files-prod.s3.amazonaws.com/4bmpzfBLmM5RUxRDnBbxyc https://cassyni.com/events/V7JYetp1tipqbpzV63ojLR/seminar/qa https://cassyni.com/slides/outline/V7JYetp1tipqbpzV63ojLR https://cassyni.com/events/V7JYetp1tipqbpzV63ojLR/abstract https://cassyni-user-files-prod.s3.amazonaws.com/PvGyURnWcoCmy5cvmDKRZp https://cassyni.com/events/V7JYetp1tipqbpzV63ojLR?videoPreview=1 Direct measurement of instantaneous wall shear stress using micromachined floating elementsnohttps://cassyni.com/events/V7JYetp1tipqbpzV63ojLR?videoPreview=12022-12-06T15:00:00+00:002945.2Experiments in FluidsRecent developments in microelectromechanical systems (MEMS)-based wall shear stress sensors have shown great promise towards providing the ability to make instantaneous, direct measurements of wall shear stress with both mean and fluctuating components. Significant challenges remain to increase sensor robustness and dc stability, reduce off-axis sensitivity while improving bandwidth and spatial resolution to accurately capture the full turbulent spectrum. This seminar presents the design, fabrication and characterization of both 1-D and 2-D micromachined wall shear stress sensor systems designed to be non-invasive to low-speed aerodynamic flows. The differential capacitive (MEMS) sensor is fabricated using a novel, low-cost approach to creating backside electrical contacts, providing a hydraulically smooth surface without the use of through-silicon vias. Fully-differential sensor electronics provide improved common-mode rejection, increased shear stress sensitivity, and reduced minimum detectable signal, thus increasing the dynamic range of the sensing system. https://cassyni-user-files-prod.s3.amazonaws.com/PvGyURnWcoCmy5cvmDKRZp https://cassyni.com/slides/outline/U81LZXWy1oigw5AUz5LQXX https://cassyni.com/events/U81LZXWy1oigw5AUz5LQXX/abstract https://cassyni-user-files-prod.s3.amazonaws.com/4kbvWiKxCajb68q4h3PXK4 https://cassyni.com/events/U81LZXWy1oigw5AUz5LQXX?videoPreview=1 Long term survivors of stereotactic radiosurgery for brain metastases: do distant brain failures reach a plateau and what factors are associated with a brain metastasis velocity of zero?nohttps://cassyni.com/events/U81LZXWy1oigw5AUz5LQXX?videoPreview=12022-12-12T21:00:00+00:001323.96Journal of Neuro-OncologyJoin Dr. Randy D'Amico and Dr. Jason Sheehan from the Journal of Neuro-Oncology as they discuss if distant brain failures reach a plateau and which factors are associated with a brain metastasis velocity of zero with co-authors Dr. Claire Lanier, Jane Pearce, and Dr. Michael Chan from Wake Forest Baptist Health. https://cassyni-user-files-prod.s3.amazonaws.com/4kbvWiKxCajb68q4h3PXK4 https://cassyni.com/events/QgFYSNR7Dhmyv5614EpbNm/seminar/qa https://cassyni.com/slides/outline/QgFYSNR7Dhmyv5614EpbNm https://cassyni.com/events/QgFYSNR7Dhmyv5614EpbNm/abstract https://cassyni-user-files-prod.s3.amazonaws.com/4TgJsfPqDQkK2ocN5gpcxv https://cassyni.com/events/QgFYSNR7Dhmyv5614EpbNm?videoPreview=1 A deep-sea isopod that consumes Sargassum sinking from the ocean’s surfacenohttps://cassyni.com/events/QgFYSNR7Dhmyv5614EpbNm?videoPreview=12025-01-21T15:00:00+00:003472.84Royal Society PublishingMost deep-ocean life relies on organic carbon from the surface ocean. While settling primary production rapidly attenuates in the water column, pulses of organic material can be quickly transported to depth in the form of food falls. One example of fresh material that can reach great depths across the tropical Atlantic Ocean and Caribbean Sea is the pelagic macroalgae Sargassum. However, little is known about the deep-ocean organisms able to use this food source. Here, we encountered the isopod Bathyopsurus nybelini at depths 5002–6288 m in the Puerto Rico Trench and Mid-Cayman Spreading Center using the Deep Submergence Vehicle Alvin. In most of the 32 observations, the isopods carried fronds of Sargassum. Through an integrative suite of morphological, DNA sequencing, and microbiological approaches, we show that this species is adapted to feed on Sargassum by using a specialized swimming stroke, having serrated and grinding mouthparts, and containing a gut microbiome that provides a dietary contribution through the degradation of macroalgal polysaccharides and fixing nitrogen. The isopod’s physiological, morphological, and ecological adaptations demonstrate that vertical deposition of Sargassum is a direct trophic link between the surface and deep ocean and that some deep-sea organisms are poised to use this material.https://cassyni-user-files-prod.s3.amazonaws.com/4TgJsfPqDQkK2ocN5gpcxv https://cassyni.com/events/Y5yc8d7yoa5pQecU27gKnm/seminar/qa https://cassyni.com/slides/outline/Y5yc8d7yoa5pQecU27gKnm https://cassyni.com/events/Y5yc8d7yoa5pQecU27gKnm/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Qmk4Rp2ZLHJKHCzyBx79dx https://cassyni.com/events/Y5yc8d7yoa5pQecU27gKnm?videoPreview=1 Women's Research In: Therapeutic Advances in Respiratory Diseasenohttps://cassyni.com/events/Y5yc8d7yoa5pQecU27gKnm?videoPreview=12025-01-17T14:00:00+00:003338.72Therapeutic Advances in Respiratory DiseaseInternational Women's Day (March 8) is a global day celebrating the achievements of women. The day also marks a call to action for accelerating women's equality. We aim to spotlight the critical role of women in research and scientific endeavours, particularly in areas where they remain underrepresented. Acknowledging their contributions is a step towards breaking down barriers, creating an inclusive environment and inspiring the next generation of women in science.   Our Special Collection, Women in Therapeutic Advances in Respiratory Disease, aims to showcase the latest research, discoveries, and perspectives of women in the field of respiratory disease, covering the key domains such as:  1. COPD 2. Asthma 3. ILD 4. Bronchiectasis/Cystic Fibrosis 5. Pulmonary Hypertension 6. Fertility/Pregnancy 7. Equity/Women work force In a committed effort to support and promote women's voices in science, each manuscript within this Special Collection proudly features at least one woman in a leading role as the first, last or corresponding author.https://cassyni-user-files-prod.s3.amazonaws.com/Qmk4Rp2ZLHJKHCzyBx79dx https://cassyni.com/slides/outline/Seqxd71CyXzk1nNERCgXoK https://cassyni.com/events/Seqxd71CyXzk1nNERCgXoK/abstract https://cassyni-user-files-prod.s3.amazonaws.com/8g9CS5HP3EPgoaFPdLWLvz https://cassyni.com/events/Seqxd71CyXzk1nNERCgXoK?videoPreview=1 Minority and Immigrant Entrepreneurs and Access to Capitalnohttps://cassyni.com/events/Seqxd71CyXzk1nNERCgXoK?videoPreview=12024-11-20T23:00:00+00:00679.56Center for Black Entrepreneurship, Spelman CollegeNo abstracthttps://cassyni-user-files-prod.s3.amazonaws.com/8g9CS5HP3EPgoaFPdLWLvz https://cassyni.com/slides/outline/6t8Ma8hQ97uNoKBK7X8GNh https://cassyni.com/events/6t8Ma8hQ97uNoKBK7X8GNh/abstract https://cassyni-user-files-prod.s3.amazonaws.com/M9EykYA48tGdKesnpV1PUA https://cassyni.com/events/6t8Ma8hQ97uNoKBK7X8GNh?videoPreview=1 Oriented areas and chain of offsets modelsnohttps://cassyni.com/events/6t8Ma8hQ97uNoKBK7X8GNh?videoPreview=12021-03-11T16:00:00+00:002531.64DataSıgOriented areas, the first non-trivial iterated integrals for multidimensional time series, can be interpreted in terms of leader-follower relationships between the observables. In many model situations, applying some spectral tools allow one to reconstruct these relationships. I will describe a few applications of these ideas, in the areas of finance and neurophysiology.https://cassyni-user-files-prod.s3.amazonaws.com/M9EykYA48tGdKesnpV1PUA https://cassyni.com/slides/outline/EHrRGPQGizDDHthn5Pyznh https://cassyni.com/events/EHrRGPQGizDDHthn5Pyznh/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Ui3jFsCuVHaevayZoKwAgv https://cassyni.com/events/EHrRGPQGizDDHthn5Pyznh?videoPreview=1 18F‑FET‑PET imaging in high‑grade gliomas and brain metastases: a systematic review and meta‑analysisnohttps://cassyni.com/events/EHrRGPQGizDDHthn5Pyznh?videoPreview=12023-01-30T21:00:00+00:001686.2Journal of Neuro-OncologyJoin Dr. Randy D'Amico and Dr. Jason Sheehan from the Journal of Neuro-Oncology for a discussion with Dr. Amit Singnurkar and Dr. Jay Detsky from Sunnybrook Research Institute about 18F‑FET‑PET imaging in high‑grade gliomas and brain metastases.https://cassyni-user-files-prod.s3.amazonaws.com/Ui3jFsCuVHaevayZoKwAgv https://cassyni.com/events/PCLMQwzRJh3NNN8qu6Kj6M/seminar/qa https://cassyni.com/slides/outline/PCLMQwzRJh3NNN8qu6Kj6M https://cassyni.com/events/PCLMQwzRJh3NNN8qu6Kj6M/abstract https://cassyni-user-files-prod.s3.amazonaws.com/FfQ8BdgSd5D8tqn4YLrgWS https://cassyni.com/events/PCLMQwzRJh3NNN8qu6Kj6M?videoPreview=1 Two examples of granular materials engineered for strength: Granular crystals and entangled matternohttps://cassyni.com/events/PCLMQwzRJh3NNN8qu6Kj6M?videoPreview=12025-01-28T15:00:00+00:004200.64Granular MatterComing from mechanical engineering, we have been focusing so far on the development of new structural materials that combine high strength and high toughness. We have had a particular interest in fully dense “architectured” materials and structures made from regular building blocks of controlled shape and size. In these designs - some of then inspired by nature - the interplay of between stiff and strong building block, geometry and weaker interfaces gives rise to a wealth of tunable mechanisms and precise structural properties. In our effort to expand some of these designs, our research trajectory recently intersected the field of granular mechanics. Our playground now is still geometry, mechanics and structural properties, but we now call our building blocks grains or particles, and we use vibrations as an assembly tool. In this talk I will discuss two types of “engineered” granular materials of interest to us. The first one is fully dense granular crystals made of space filling polyhedral grains, and which are 10 times stronger than traditional granular materials. These granular crystals display a rich set of mechanisms which we are investigating using experiments and discrete element models: Nonlinear deformations, crystal plasticity reminiscent of atomistic mechanisms, geometric strain hardening, micro-buckling. Our other granular material of interest is engineered entangled matter. I will discuss the experiments we use to measure entanglement and strength as function of particle geometry, and how we are capturing entanglement mechanisms at multiple length scales using Monte Carlo simulations and discrete element models. We envision that these engineered granular materials will offer combinations of strength, toughness and recyclability that will rival the capabilities of existing structural materials. https://cassyni-user-files-prod.s3.amazonaws.com/FfQ8BdgSd5D8tqn4YLrgWS https://cassyni.com/slides/outline/HmChuRseUexHyVtcJBKw6u https://cassyni.com/events/HmChuRseUexHyVtcJBKw6u/abstract https://cassyni-user-files-prod.s3.amazonaws.com/3JGQaYJ2tyqmwer57L8gWA https://cassyni.com/events/TeAnq6p9Fp2cq1tdok6JEq/seminar/qa https://cassyni.com/slides/outline/TeAnq6p9Fp2cq1tdok6JEq https://cassyni.com/events/TeAnq6p9Fp2cq1tdok6JEq/abstract https://cassyni-user-files-prod.s3.amazonaws.com/NHubUTAgCvKMSYrYjZRogJ https://cassyni.com/events/TeAnq6p9Fp2cq1tdok6JEq?videoPreview=1 Unconventional Water Resources: Opportunities, Challenges and Solutions for Water Managementnohttps://cassyni.com/events/TeAnq6p9Fp2cq1tdok6JEq?videoPreview=12025-03-25T13:30:00+00:004624.12Springer Nature Sustainable Development Goals ProgrammeSDG6 states that achieving "clean water and sanitation for all" is essential for the development of human society. Understanding the Earth's water resources (both quantitatively and qualitatively) is a key premise for implementing activities aimed at achieving this SDG. In addition, climate change poses new issues for water management and the development of new tools to address water scarcity in a large area of our planet has become mandatory. Among them, wastewater reuse is a powerful tool deserving special attention to be implemented without risks for humans and the environment. In this SDG Talk, water resources experts will provide not only an overview of water resources on Earth, but will also explain the potential of unconventional water resources exploitation, with specific focus on wastewater reuse; the case study of the Murcia region (Spain) will be presented. Image credit: [Amritanshu Sikdar (Unsplash)](https://unsplash.com/photos/water-drop-on-bucket-photo-LoGnr-w1D8E).https://cassyni-user-files-prod.s3.amazonaws.com/NHubUTAgCvKMSYrYjZRogJ https://cassyni.com/slides/outline/S9af4a2Bg94f8HkHdArHN5 https://cassyni.com/events/S9af4a2Bg94f8HkHdArHN5/abstract https://cassyni-user-files-prod.s3.amazonaws.com/GaYsiL7isqRWUk6s4sHUZL https://cassyni.com/events/S9af4a2Bg94f8HkHdArHN5?videoPreview=1 ORCID + Accessibilitynohttps://cassyni.com/events/S9af4a2Bg94f8HkHdArHN5?videoPreview=12024-05-16T14:00:00+00:003531.96ORCIDORCID believes that ORCID should be open and accessible to all, in order to serve the global community and move toward our vision of a world where all who participate in research, scholarship, and innovation are uniquely identified and connected to their contributions across disciplines, borders, and time. According to the Web Accessibility Initiative (WAI), for an online technology to be accessible, it must be, “designed and developed so that people with disabilities can use them.” To align with this initiative, an accessibility audit in 2022 served as a catalyst for ORCID to begin the ongoing work of making significant accessibility improvements within the ORCID Registry. Join us for this webinar with ORCID Senior UX Designer Dan Dineen to learn about the process of identifying areas in need of improvement, the work that has been done thus far, and the ongoing journey ORCID is committed to undertaking to ensure ORCID is accessible to all.https://cassyni-user-files-prod.s3.amazonaws.com/GaYsiL7isqRWUk6s4sHUZL https://cassyni.com/slides/outline/9N6ZmvL4onm5hD6sVggVUh https://cassyni.com/events/9N6ZmvL4onm5hD6sVggVUh/abstract https://cassyni-user-files-prod.s3.amazonaws.com/BCdfnpWxZxyH56k3m6wL46 https://cassyni.com/events/9N6ZmvL4onm5hD6sVggVUh?videoPreview=1 Algorithms and Explanations: Regulatory Approaches to Explanationnohttps://cassyni.com/events/9N6ZmvL4onm5hD6sVggVUh?videoPreview=12017-05-09T10:00:00+00:004540.44 School of Public PolicyInformation Law Institute at New York University School of Law Panelists: - Sandra Wachter, University of Oxford, Oxford Internet Institute - Julie Brill, Hogan Lovells - Deven Desai, Georgia Tech (Law and Ethics) - Alison Howard, Microsoft Moderator: Ira Rubinstein, NYU (Law)https://cassyni-user-files-prod.s3.amazonaws.com/BCdfnpWxZxyH56k3m6wL46 https://cassyni.com/slides/outline/BqLb1LZh15Xa49aS3Nb8Cd https://cassyni.com/events/BqLb1LZh15Xa49aS3Nb8Cd/abstract https://cassyni-user-files-prod.s3.amazonaws.com/3nkNTHfJcPGs6faKvMpZ2n https://cassyni.com/events/BqLb1LZh15Xa49aS3Nb8Cd?videoPreview=1 Fluid Mechanics and the Evolution of Biological Complexitynohttps://cassyni.com/events/BqLb1LZh15Xa49aS3Nb8Cd?videoPreview=12024-09-26T12:00:00+00:004062.96The Edinburgh Fluid Dynamics Group (EFDG)A fundamental issue in biology is the nature of evolutionary transitions from unicellular to multicellular organisms: What are the advantages of being physically larger and more complex? Green algae are models for this transition, as they span from unicellular species to multicellular ones with tens of thousands of cells, all of which swim through the action of flagella that are closely related to the cilia found throughout the human body. A paradigm for understanding this transition is the phenomenon of phototaxis, directed motion toward light. In this talk I will describe experimental and theoretical work on the physical mechanism of algal phototaxis, spanning 3 orders of magnitude in cell number, that reveals an evolutionarily conserved response which raises interesting questions in fluid mechanics, dynamical systems, and cellular decision-making.https://cassyni-user-files-prod.s3.amazonaws.com/3nkNTHfJcPGs6faKvMpZ2n https://cassyni.com/slides/outline/VchxnaNUCvPZE1gHGkwX9w https://cassyni.com/events/VchxnaNUCvPZE1gHGkwX9w/abstract https://cassyni-user-files-prod.s3.amazonaws.com/W2V9uzzNAh5mVpaxdfNVrn https://cassyni.com/events/VchxnaNUCvPZE1gHGkwX9w?videoPreview=1 EP1: Quantum Computing and Brain-Inspired Computingnohttps://cassyni.com/events/VchxnaNUCvPZE1gHGkwX9w?videoPreview=12024-09-18T08:00:00+00:007181.92Institute of Natural Sciences第一期研讨会邀请上海交通大学自然科学研究院院长、数学科学学院讲席教授金石，上海交通大学自然科学研究院、数学科学学院教授李松挺，上海交通大学自然科学研究院、密西根学院副教授Nana Liu，围绕量子计算与类脑计算展开讨论。https://cassyni-user-files-prod.s3.amazonaws.com/W2V9uzzNAh5mVpaxdfNVrn https://cassyni.com/slides/outline/9rmnwEVUecEuWygEFdQnt5 https://cassyni.com/events/9rmnwEVUecEuWygEFdQnt5/abstract https://cassyni-user-files-prod.s3.amazonaws.com/9FLRkABBcZ1swfLobPsY94 https://cassyni.com/events/9rmnwEVUecEuWygEFdQnt5?videoPreview=1 Genomic surveillance of pathogensnohttps://cassyni.com/events/9rmnwEVUecEuWygEFdQnt5?videoPreview=12024-06-05T15:00:00+00:005136.92Frontiers in ScienceThis article advocates for mobilizing pathogen genomic surveillance to contain and mitigate health threats from infectious diseases and antimicrobial resistance (AMR), building upon successes achieved by large-scale genome sequencing analysis of SARS-CoV-2 variants in guiding COVID-19 monitoring and public health responses and adopting a One Health approach. Capabilities of laboratory-based surveillance and epidemic alert systems should be enhanced by fostering (i) universal access to real-time whole genome sequence (WGS) data of pathogens to inform clinical practice, infection control, public health policies, and vaccine and antimicrobial drug research and development; (ii) integration of diagnostic microbiology data, data from testing asymptomatic individuals, pathogen sequence data, clinical data, and epidemiological data into surveillance programs; (iii) stronger cross-sectorial collaborations between healthcare, public health, animal health, and environmental surveillance and research using One Health approaches, toward understanding the ecology and transmission pathways of pathogens and AMR across ecosystems; (iv) international collaboration and interconnection of surveillance networks, harmonization of laboratory methods, and standardization of surveillance methods for global reporting, including on pathogen genomic variant or strain nomenclature; (v) responsible data sharing between surveillance networks, databases, and platforms according to FAIR (findability, accessibility, interoperability, and reusability) principles; and (vi) research on genomic surveillance system implementation and its cost-effectiveness for different pathogens and AMR threats across different settings. Regional and global One Health policies and governance initiatives should foster the concerted development and efficient utilization of pathogen genomic surveillance to protect the health of humans, animals, and the environment.https://cassyni-user-files-prod.s3.amazonaws.com/9FLRkABBcZ1swfLobPsY94 https://cassyni.com/slides/outline/HGXUk7iEdqUUA2u6W5Cxvh https://cassyni.com/events/HGXUk7iEdqUUA2u6W5Cxvh/abstract https://cassyni-user-files-prod.s3.amazonaws.com/CfMXdmEqPeachd46yYCfpz https://cassyni.com/events/HGXUk7iEdqUUA2u6W5Cxvh?videoPreview=1 Regional climate change impactsnohttps://cassyni.com/events/HGXUk7iEdqUUA2u6W5Cxvh?videoPreview=12024-11-07T15:00:00+00:005264.68Frontiers in ScienceIn this Frontiers Forum Deep Dive session on 7 November, Prof Mat Collins, Prof Gabriele Hegerl, explored expected climate hazards in different parts of the world, and how to move from assessing these to effective mitigation and adaptation actions. They were joined by Prof Swadhin Behera, and Prof Shang-Ping Xie for a panel discussion and audience Q&A. The session brought together the authors of the Frontiers in Science lead article ‘Emerging signals of climate change from the equator to the poles: new insights into a warming world’ to discuss how monsoons, storms, extreme events, and other phenomena are expected to change this century—and how deeper assessments of regional climate risks and vulnerability are essential for informing climate policy and adaptation measures. https://cassyni-user-files-prod.s3.amazonaws.com/CfMXdmEqPeachd46yYCfpz https://cassyni.com/events/8NtE2Sag8xRk4Rr8tSVzYd/seminar/qa https://cassyni.com/slides/outline/8NtE2Sag8xRk4Rr8tSVzYd https://cassyni.com/events/8NtE2Sag8xRk4Rr8tSVzYd/abstract https://cassyni-user-files-prod.s3.amazonaws.com/BJfumtzDiwDxz4AD4CVPK4 https://cassyni.com/events/8NtE2Sag8xRk4Rr8tSVzYd?videoPreview=1 The Construction of Latinidad Within Speculative Fictionnohttps://cassyni.com/events/8NtE2Sag8xRk4Rr8tSVzYd?videoPreview=12025-06-18T16:00:00+00:002703.44Lived Places PublishingSpeculative fiction, the broad category that includes genres such as science fiction, high-fantasy, superhero narratives, and many others, has often served as a space to explore contemporary social issues, anxieties about the past, and visions of the future. Historically, these types of narratives have involved the vivid articulation of societal “others,” those who belong to groups that in our world are stigmatized as being substantially different and thus exotic and/or threatening. For creators from dominant society these stories were opportunities to treat “others” as playthings to be experimented with and upon for entertainment or social critique. For those of us from the margins, these stories have been battlegrounds where our identities fought for survival. This session explores ways in which contemporary speculative fiction constructs *Latinidad* in ways that advance humanizing depictions of Latinx people, as well as those cases where narratives reinforce reductive understandings about *Latinidad*.https://cassyni-user-files-prod.s3.amazonaws.com/BJfumtzDiwDxz4AD4CVPK4 https://cassyni.com/events/3SQBZc7RkNtifL8nsxnzpV/abstract https://cassyni-user-files-prod.s3.amazonaws.com/DJZdTAEjCfcV4K4JCjsB66 https://cassyni.com/events/Dp1sXxhSxzX9BqRvu4jtW1/abstract https://cassyni-user-files-prod.s3.amazonaws.com/4uJryMjaBbdPa8gjPSvfta https://cassyni.com/events/Ph1aaG9q9WXCBq8MhCShGZ/abstract https://cassyni-user-files-prod.s3.amazonaws.com/6rkk6xUXnANEN8m3bZNUu4 https://cassyni.com/slides/outline/KjmVyXwrq8ExWyNf3m7bed https://cassyni.com/events/KjmVyXwrq8ExWyNf3m7bed/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Sgexryij4DHokFvqmEzKZY https://cassyni.com/events/KjmVyXwrq8ExWyNf3m7bed?videoPreview=1 Environmental control of stomatal formationnohttps://cassyni.com/events/KjmVyXwrq8ExWyNf3m7bed?videoPreview=12024-10-22T13:00:00+00:001899.04The New Phytologist FoundationHow does the environment affect cell fate? My research group employs stomatal development in plants as a model system to explore the influence of external signals on cell fate decisions at the molecular and cell lineage level. The development of stomata—the surface pores on plants critical for gas and water vapour exchange—represents an excellent model because stomatal production is highly responsive to diverse environmental stimuli and its regulation has strong implications to agricultural production. In my talk, I will discuss our recent efforts in addressing how external signals, such as drought, modulate stomatal formation. By focusing on the stem cell-like stomatal precursor cells, we elucidated the mechanism underlying these responses and identified key nodes in the plasticity of stomatal production. Our works highlight how the production of a specific cell type can be controlled and coordinated, and how the insights may be applied to improve plant fitness.https://cassyni-user-files-prod.s3.amazonaws.com/Sgexryij4DHokFvqmEzKZY https://cassyni.com/events/Wc63DqDBHvGyge7w4e1dRF/seminar/qa https://cassyni.com/slides/outline/Wc63DqDBHvGyge7w4e1dRF https://cassyni.com/events/Wc63DqDBHvGyge7w4e1dRF/abstract https://cassyni-user-files-prod.s3.amazonaws.com/BhDTXCGL433pEtrn472Man https://cassyni.com/events/Wc63DqDBHvGyge7w4e1dRF?videoPreview=1 Impact of surface patterning on membrane performance: experimental analysis of CaSO4 scaling and hydrodynamic insights from PIVnohttps://cassyni.com/events/Wc63DqDBHvGyge7w4e1dRF?videoPreview=12025-03-31T08:00:00+00:003427.8Elsevier Surface patterning of thin-film composite (TFC) membranes has emerged as a promising approach to enhance membrane performance in water treatment and desalination applications [1]. Numerous studies have demonstrated that imprinted surface patterns can induce local mixing effects, mitigating biofouling and scaling [2, 3], while also increasing the membrane’s active surface area, thereby improving pure water permeability (PWP) [4]. However, none of the respective studies investigated the performance of surface-patterned TFC membranes in combination with feed spacers, which are typical components in spiral-wound modules. Moreover, the direct patterning of dense reverse osmosis (RO) membranes via thermal embossing presents challenges, as significant plastic deformation may damage the crosslinked polyamide layer, negatively impacting PWP and/or permselectivity [5]. So far, the preparation of surface-patterned TFC membranes via a two-step approach [3, 4] (i.e., surface patterning of the membrane support followed by interfacial polymerization) has been the most reliable option. In this presentation, the development of surface-patterned RO TFC membranes with pronounced regular microstructures via the direct patterning thermal embossing method will be discussed. A systematic study of the imprinting conditions and their impacts on both the topographical characteristics and permselectivity of TFC membranes was conducted. Additionally, the results of lab-scale scaling experiments using surface patterned TFC membranes, combined with typical diamond-shaped feed spacer, will be presented. Furthermore, simulations and lab-scale experiments, conducted in spacer-free channels, revealed that surface-patterned membranes can modify fluid characteristics in direct membrane vicinity, and accordingly, decrease both membrane fouling and concentration polarization[4, 6]. Several mechanistic explanations (e.g., vortex shielding, secondary flow generation, shear-induced back-diffusion) were proposed in literature [1]; however, they were either rather case-specific or sometimes even contradictory. To date, there is no solid experimental evidence concerning the improved fluid characteristics in the immediate vicinity of surface-structured membranes. The current study aims at sufficient understanding of the effect(s) of topographical membrane surface modification on fluid characteristics and examinesreliable mechanisms for particles (or foulants) deposition on surface-patterned membranes in spacer-filled channels by means of real-time hydrodynamic analysis using Particle Image Velocimetry (PIV). Experimental: Surface-patterned TFC membranes were prepared via hot embossing micro-imprinting lithography using commercial FilmTec™ LC LE-4040 membranes and a brass mold (27 × 7 cm²) featuring a regular lines-and-grooves pattern (line width: 20 μm, line-to-line distance: 20 μm, groove depth: 10 μm). The patterning fidelity was analyzed using 3D optical profilometer, while topographical characteristics (e.g., roughness) were analyzed using scanning electron microscopy and atomic force microscopy. Membrane performance was assessed via lab-scale testing of PWP and NaCl retention. Anti-Scaling performance, with/-out feed spacer, was compared vs. two reference flat-sheet membranes (pristine membrane and compacted membrane at analogous conditions as surface-patterned membrane). Hydrodynamic analyses were carried out with constant crossflow velocity of 0.15 m/s. Tracer particles with different characteristics were employed. Shake-the-Box (STB, Lagrangian Particle tracking) PIV with instantaneous measurement of three velocity components in a complete 3D measurement volume was employed. Different operating conditions (with/-out permeation, with/-out feed spacer) were examined. Results and discussion: Surface-patterned TFC membranes with pronounced microstructures (pattern height up to 5 μm) were successfully achieved while maintaining dense polyamide layer, see Fig.1.(a), a correlation between patterns dimensions and PWP could be established. Additionally, surface-patterned membrane exhibited generally better antiscaling performance than flat membranes, while performance results in cases of feed spacer-free and feed spacer-filled channels differ substantially. Hydrodynamic measurement using STB in spacer-free channel at non-permeation and permeation conditions revealed that surface-patterning can indeed modify fluid characteristics in the feed-retentate channel. This was consistent with our earlier measurements using planar 2D-PIV[7], where vector velocity profiles showed substantially improved fluid characteristics for surface-patterned membranes compared to flat-sheet membranes. Acknowledgments This work is funded by the German Research Foundation (DFG) – project number: 499318495.https://cassyni-user-files-prod.s3.amazonaws.com/BhDTXCGL433pEtrn472Man https://cassyni.com/slides/outline/DKLeNeY38B3KNNSR6xcvKo https://cassyni.com/events/DKLeNeY38B3KNNSR6xcvKo/abstract https://cassyni-user-files-prod.s3.amazonaws.com/4uttRznkUP7bVp6Pds4Lbg https://cassyni.com/events/DKLeNeY38B3KNNSR6xcvKo?videoPreview=1 Extracellular Matrix Scaffold-Assisted Tumor Vaccines Induce Tumor Regression and Long-Term Immune Memorynohttps://cassyni.com/events/DKLeNeY38B3KNNSR6xcvKo?videoPreview=12025-07-17T18:00:00+00:002920.68Center for Cancer TrainingMaterials that interact with biological systems have been engineered for biomedical applications. These biomaterials have revolutionized cancer care by enabling targeted and sustained drug delivery, reducing side effects, promoting tissue regeneration and recovery. However, every implanted biomaterial triggers a spectrum of host immune responses that depend on its composition and architecture, ultimately affecting its function. Extracellular matrix (ECM) scaffolds derived from decellularized mammalian tissues are implanted in patients to surgically reconstruct damaged tissues following tumor resection. These scaffolds initiate a Type 2 immune response driven by the IL-4 cytokine, promoting scaffold remodeling and tissue regeneration. While previous studies have explored the use of ECM scaffolds in cancer care, a few have investigated their potential as delivery platforms for cancer vaccines, particularly in inducing cytotoxic immunity. In this study, we developed an injectable cancer vaccine using an ECM scaffold made from decellularized small intestinal submucosa (SIS). We screened cancer vaccine adjuvants for co-delivery with an ECM scaffold by subcutaneous implantation in mice, and it was discovered that a molecule called cyclic di-AMP, which activates the STING pathway, was the most effective at triggering a strong immune response without interfering with healing processes that rely on interleukin 4 (IL-4). The use of the ECM scaffold significantly enhanced therapeutic vaccine efficacy, curing 50–75% of lymphoma tumors in mice, while no tumors were cured with the soluble vaccine without the scaffold. SIS-ECM scaffold-assisted vaccination generated long-term antigen-specific memory, producing 4-fold effector memory CD8+ T cells (Tem) in response to tumor challenge compared to untreated controls. In conclusion, ECM scaffolds are a promising delivery system for cancer vaccines. They enhance vaccine effectiveness while preserving the immune response needed for tissue repair, offering potential for localized immunotherapy after tumor removal in clinical settings.https://cassyni-user-files-prod.s3.amazonaws.com/4uttRznkUP7bVp6Pds4Lbg https://cassyni.com/slides/outline/CL3SHHEzFFwAhccQzz9bWu https://cassyni.com/events/CL3SHHEzFFwAhccQzz9bWu/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Ja1pgCdFNvCJNVKnaGbdLa https://cassyni.com/events/CL3SHHEzFFwAhccQzz9bWu?videoPreview=1 Extreme Control of Light with Metamaterialsnohttps://cassyni.com/events/CL3SHHEzFFwAhccQzz9bWu?videoPreview=12025-02-28T14:00:00+00:003075.04UK Metamaterials NetworkThe field of metamaterials, artificial engineered materials, has been rapidly evolving in the past two decades, demonstrating extreme optical phenomena and unprecedented control over wave propagation. In this talk, I discuss recent developments in metamaterials research in our group, with an emphasis on the role of symmetries in establishing emerging optical responses for metamaterials based on otherwise simple constituents. Geometrical rotations, suitably tailored perturbations, and broken time reversal symmetry can be carefully engaged to tailor waves in robust and efficient ways, control their propagation, break Lorentz reciprocity and enable topological order and phase transitions. The use of strongly coupled light and matter interactions in polaritonic systems enables extreme responses at the nanoscale, well suited for classical-wave and quantum applications. In my talk, I will discuss the underlying physical principles that span over a wide range of frequencies, and their impact on practical technologies, from imaging, energy and sensing to computing and communications.https://cassyni-user-files-prod.s3.amazonaws.com/Ja1pgCdFNvCJNVKnaGbdLa https://cassyni.com/slides/outline/W7Qp4X3mT6o9sB8RGXtfF3 https://cassyni.com/events/W7Qp4X3mT6o9sB8RGXtfF3/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Etwe9NFXs5LPvBXhSo44dL https://cassyni.com/events/W7Qp4X3mT6o9sB8RGXtfF3?videoPreview=1 Predictions of Human Prostate Cancer with NMR Metabolomics from Biopsies, New Development in Cardiac Function Assessment with Cardiac Magnetic Resonance: From Cells to AInohttps://cassyni.com/events/W7Qp4X3mT6o9sB8RGXtfF3?videoPreview=12025-02-09T23:00:00+00:006224.04The Auckland Bioengineering InstituteProstate cancer (PCa) is one of the most prevalent and fatal malignancies for men worldwide. Standard screening and diagnostic tools, including prostate specific antigen (PSA) testing, digital rectal examinations (DRE), and 12-core transrectal ultrasound (TRUS) biopsy, suffer from a lack of PCa-specificity and sensitivity, resulting in overtreatment of indolent PCa. The combination of multiparametric magnetic resonance imaging (mpMRI) and ultrasound allows for improved visualization of anatomical structures, assessment of tumor aggressiveness, and probe-tracking capabilities; however, such a Fusion biopsy is still prone to false-positive and false-negative results due to the presence of various factors. Metabolomics, as a promising field for cancer biomarker discovery, can provide new perspectives for evaluating PCa prognosis, aggressiveness, and clinical significance. In this study of >15 years, we present the capacity for metabolomic analyses to not only distinguish between PCa and benign tissues, but also differentiate patients who are diagnosed with PCa years after initial negative biopsy. Over a period of 15 years and with 10 years of follow-up up till now, 432 biopsy cores from 332 patients with suspicious for PCa underwent TRUS (n=232) and Fusion (n=100) biopsies. One core from TRUS biopsies, and two cores (one target and one non-target core opposite the target) from Fusion biopsies underwent ex vivo MRS analysis. All cores were analyzed by high-resolution magic angle spinning (HRMAS) MRS on a Bruker 600MHz spectrometer at 4ºC with a rotor-synchronized Min(A,B) protocol with spinning at 600 and 700Hz. Spectra were curve-fit and transformed into statistical matrices using a MATLAB-based program. Metabolic spectral regions of interest (ROIs) (n=48) with >60% of samples presenting detectable values were analyzed with principal component analysis (PCA) and other statistical tools. Following the MRS analysis, all 432 cores returned to pathology for quantitative pathology evaluation and recorded in patient records. In this presentation, we will demonstrate the capability of measuring PCa metabolomics non-destructively from human biopsy cores using ex vivo HRMAS MRS, and present PCa metabolomic predictive potential measured from biopsy cores through patient follow-ups 5~15 years. Most notably, predictions of negative biopsy patients to be discovered with PCa within 5 years may be achieved with MRs-based metabolomics, while longer follow-ups are needed and continued in our laboratory. This talk will focus on recent developments in the use of cardiovascular magnetic resonance (CMR) to evaluate cardiac function, perfusion, myocardial mechanics, and the role of artificial intelligence in research and clinical CMR applications. https://cassyni-user-files-prod.s3.amazonaws.com/Etwe9NFXs5LPvBXhSo44dL https://cassyni.com/slides/outline/2wkaWvTuJvLffZbuHXWCZB https://cassyni.com/events/2wkaWvTuJvLffZbuHXWCZB/abstract https://cassyni-user-files-prod.s3.amazonaws.com/6v34KBNw4ywVWVxCyj4WPx https://cassyni.com/events/2wkaWvTuJvLffZbuHXWCZB?videoPreview=1 Nonlinear Stability Meets High-Order Flux Reconstructionnohttps://cassyni.com/events/2wkaWvTuJvLffZbuHXWCZB?videoPreview=12024-12-06T17:00:00+00:001900.52JKW Symposium TeamEnsuring provable nonlinear stability provides bounds on the discrete solution and guarantees that the numerical scheme remains convergent. In the context of compressible flows, nonlinear stability is achieved by enforcing a secondary conservation principle—the second law of thermodynamics. For high-order numerical methods, such as discontinuous Galerkin (DG), discrete nonlinear and entropy stability have been effectively realized. These stability guarantees are typically derived using properties of the L2-norm. We have developed a nonlinearly stable flux reconstruction (NSFR) scheme for three-dimensional compressible flow in curvilinear coordinates. NSFR is derived by merging the energy stable flux reconstruction (ESFR) framework with entropy stable DG schemes. NSFR is demonstrated to continue to benefit from the use of larger time-steps than DG due to the ESFR correction functions while preserving discrete nonlinear stability. NSFR differs from ESFR schemes in the literature since it incorporates the FR correction functions on the volume terms through the use of a modified mass matrix. We employ a modified mass matrix in a weight-adjusted form that reduces the computational cost in curvilinear coordinates through a precomputed projection operator that approximates the dense matrix inversion and the inverse of a diagonal matrix on-the-fly and exploits the tensor product basis functions to utilize sum factorization. A novel, fully-discrete, nonlinearly stable flux reconstruction (FD-NSFR) framework is introduced, which guarantees entropy stability in both spatial and temporal domains for high-order methods via the relaxation Runge-Kutta scheme. We developed an FD-NSFR scheme that prevents a temporal numerical entropy change in the broken Sobolev norm if the governing equations admit a convex entropy function that can be expressed in inner-product form. Through the use of a bound-preserving limiter, positivity of thermodynamic quantities is preserved and enables the extension of this scheme to hyperbolic conservation laws. Lastly, we perform a computational cost comparison between conservative DG, overintegrated DG, and our proposed entropy-conserving NSFR scheme and find that our proposed entropy-conserving NSFR scheme is computationally competitive with the conservative DG scheme. https://cassyni-user-files-prod.s3.amazonaws.com/6v34KBNw4ywVWVxCyj4WPx https://cassyni.com/slides/outline/CpifSbQQ65QzX5bvo6GZh7 https://cassyni.com/events/CpifSbQQ65QzX5bvo6GZh7/abstract https://cassyni-user-files-prod.s3.amazonaws.com/AjgmYLb7Gf7FmsL7vFsqA6 https://cassyni.com/events/CpifSbQQ65QzX5bvo6GZh7?videoPreview=1 Effective Publication Strategies: 12 Tips for Selecting the Right Journal for Your Research and Scholarshipnohttps://cassyni.com/events/CpifSbQQ65QzX5bvo6GZh7?videoPreview=12024-06-24T08:00:00+00:003823.32AAMCIn this video, Andrea Berry, MPA, PhDc, Pamela Herring, MLIS, D-AHIP, and Judy M. Spak, MLS, present strategies for finding the right home for your scholarship and maximizing your publication success. They also share the recently updated AAMC Group on Educational Affairs (GEA) Medical Education Scholarship Research and Evaluation (MESRE) Annotated Bibliography, which includes information about the manuscript types, topics, and audience for more than 75 journals that publish educational scholarship. This webinar is part of the Scholarly Publishing Webinar Series, hosted by Academic Medicine and MedEdPORTAL. For more information on the complete series, see [aamc.org/publishingwebinar](https://www.aamc.org/about-us/mission-areas/medical-education/scholarly-publishing-webinar-series).https://cassyni-user-files-prod.s3.amazonaws.com/AjgmYLb7Gf7FmsL7vFsqA6 https://cassyni.com/events/RfbzkzjvuLjxHYQb4AJdh7/seminar/qa https://cassyni.com/slides/outline/RfbzkzjvuLjxHYQb4AJdh7 https://cassyni.com/events/RfbzkzjvuLjxHYQb4AJdh7/abstract https://cassyni-user-files-prod.s3.amazonaws.com/KTaRumLFDBsnLcnusapvJi https://cassyni.com/events/RfbzkzjvuLjxHYQb4AJdh7?videoPreview=1 Network-based anomaly detection algorithm reveals proteins with major roles in human tissuesnohttps://cassyni.com/events/RfbzkzjvuLjxHYQb4AJdh7?videoPreview=12025-04-08T15:00:00+00:001846.56GigaScience PressBackground: Proteins act through physical interactions with other molecules to maintain organismal health. Protein-protein interaction (PPI) networks proved to be a powerful framework for obtaining insight into protein functions, cellular organization, response to signals, and disease states. In multicellular organisms, protein content varies between tissues, influencing tissue morphology and function. Weighted PPI networks, reflecting the likelihood of interactions in specific tissues, offer insights into tissue-specific processes and disease mechanisms. We hypothesized that detecting anomalous nodes in these networks could reveal proteins with key tissue-specific functions. Results: Here, we introduce Weighted Graph Anomalous Node Detection (WGAND), a novel machine-learning algorithm to identify anomalous nodes in weighted graphs. WGAND estimates expected edge weights and uses deviations to generate anomaly detection features, which are then used to score network nodes. We applied WGAND to weighted PPI networks of 17 human tissues. High-ranking anomalous nodes were enriched for proteins associated with tissue-specific diseases and tissue-specific biological processes, such as neuron signaling in the brain and spermatogenesis in the testis. WGAND outperformed other methods in terms of Area Under the ROC Curve (AUC) and Precision at K (P@K), highlighting its effectiveness in uncovering biologically meaningful anomalies. Conclusion: Our findings demonstrate WGAND’s potential as a powerful tool for detecting anomalous proteins with significant biological roles. By identifying proteins involved in critical tissue-specific processes and diseases, WGAND offers valuable insights for discovering novel biomarkers and therapeutic targets. Its versatile algorithm is suitable for any weighted graph and is broadly applicable across various fields. The WGAND algorithm is available as an open-source Python library at https://github.com/data4goodlab/wgand.https://cassyni-user-files-prod.s3.amazonaws.com/KTaRumLFDBsnLcnusapvJi https://cassyni.com/slides/outline/X6jeGWrhjNq2gQepf5JRgZ https://cassyni.com/events/X6jeGWrhjNq2gQepf5JRgZ/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Hsb85j6Ett8aPui1nNmdD8 https://cassyni.com/events/X6jeGWrhjNq2gQepf5JRgZ?videoPreview=1 Move Analysis of Academic and Professional Discourse: From Patterns to Publications and Successful Workplace Communicationnohttps://cassyni.com/events/X6jeGWrhjNq2gQepf5JRgZ?videoPreview=12025-04-07T00:00:00+00:003653.04Linguistics and Applied Language StudiesDiscourse analysis encompasses various approaches, but the one most closely associated with English for Specific Purposes (ESP) is genre analysis, commonly referred to as move analysis. This approach applies to both academic and professional discourse, focusing on uncovering the structural patterns that genres exhibit. These patterns consist of “moves,” each can be subdivided into “steps,” which together serve specific communicative purposes. In academic discourse, particularly research articles (RAs), numerous studies have analyzed individual sections (e.g., Introduction, Methods, Results, Discussion), while fewer have explored entire articles. These studies reveal that RA sections, regardless of discipline, tend to follow specific organizational patterns aimed at achieving shared communicative goals. Furthermore, these moves and steps are often associated with distinctive linguistic features that enhance coherence and precision. In professional discourse, genres such as business pitches, reports, and proposals have also been subjected to move analysis, albeit to a lesser extent than academic genres. Findings suggest that these genres, like RAs, exhibit predictable organizational patterns, though they are often tailored to specific audiences and pragmatic needs. For instance, professional genres emphasize persuasion, clarity, and audience engagement through precise language and strategic structuring. While linguistic and cultural differences influence both academic and professional discourse, these variations provide valuable insights into adapting writing for diverse contexts. Move analysis offers a practical framework for helping both researchers and professionals align their work with established conventions while achieving their communicative goals. This talk highlights the pedagogical value of move analysis in fostering academic literacy and professional communication skills. By demystifying the structural and linguistic patterns of both academic and professional genres, it provides actionable strategies for enhancing research visibility, improving publication success, and refining workplace communication. https://cassyni-user-files-prod.s3.amazonaws.com/Hsb85j6Ett8aPui1nNmdD8 https://cassyni.com/slides/outline/6QKRxLWTnV95WxN68riKzu https://cassyni.com/events/6QKRxLWTnV95WxN68riKzu/abstract https://cassyni-user-files-prod.s3.amazonaws.com/FayBmkqe8MDjNsSUnuT5dx https://cassyni.com/events/6QKRxLWTnV95WxN68riKzu?videoPreview=1 Scattering from a random thin coating of nanoparticles: the Dirichlet casenohttps://cassyni.com/events/6QKRxLWTnV95WxN68riKzu?videoPreview=12025-06-24T13:00:00+00:003412.32MetaMATWe study the time-harmonic scattering by a heterogeneous object covered with a thin layer of randomly distributed sound soft nanoparticles. The size of the particles, their distance between each other and the layer's thickness are all of the same order but small compared to the wavelength of the incident wave. Solving the Helmholtz equation in this context is impossible since the distribution of the particles is not known. To circumvent this, we propose, via a multi-scale asymptotic expansion of the solution, an effective model where the layer of particles is replaced by an equivalent boundary condition. The coefficients that appear in this equivalent boundary condition depend on the solutions to corrector problems of Laplace type defined on unbounded random domains. Under the assumption that the particles are distributed given a stationary and mixing random point process, we prove that those problems admit a unique solution in the proper space. We then establish quantitative error estimates for the effective model and present numerical simulations that illustrate our theoretical results.https://cassyni-user-files-prod.s3.amazonaws.com/FayBmkqe8MDjNsSUnuT5dx https://cassyni.com/slides/outline/TqPVW3DPuc47rek8P1LGm https://cassyni.com/events/TqPVW3DPuc47rek8P1LGm/abstract https://cassyni-user-files-prod.s3.amazonaws.com/LuQnMs8qncZmSBB29oPFK4 https://cassyni.com/events/TqPVW3DPuc47rek8P1LGm?videoPreview=1 Multifidelity, domain decomposition, and stacking for improving training for physics-informed networksnohttps://cassyni.com/events/TqPVW3DPuc47rek8P1LGm?videoPreview=12025-04-25T19:00:00+00:003362.84AI Institute in Dynamic SystemsPhysics-informed neural networks and operator networks have shown promise for effectively solving equations modeling physical systems. However, these networks can be difficult or impossible to train accurately for some systems of equations. One way to improve training is through the use of a small amount of data, however, such data is expensive to produce. We will introduce our novel multifidelity framework for stacking physics-informed neural networks and operator networks that facilitates training by progressively reducing the errors in our predictions for when no data is available. In stacking networks, we successively build a chain of networks, where the output at one step can act as a low-fidelity input for training the next step, gradually increasing the expressivity of the learned model. We will finally discuss the extension to domain decomposition using the finite basis method, including applications to newly-developed Kolmogorov-Arnold Networks. Applications will be discussed for accelerating simulations of computational fluid dynamics.https://cassyni-user-files-prod.s3.amazonaws.com/LuQnMs8qncZmSBB29oPFK4 https://cassyni.com/slides/outline/BLoURAyiB4gNyNemdwmhQh https://cassyni.com/events/BLoURAyiB4gNyNemdwmhQh/abstract https://cassyni-user-files-prod.s3.amazonaws.com/TeRDaZq2W6FoLkTMwdSjkJ https://cassyni.com/events/BLoURAyiB4gNyNemdwmhQh?videoPreview=1 The Role of Philanthropic Foundations and Donors in the Preservation of Invisible Biodiversitynohttps://cassyni.com/events/BLoURAyiB4gNyNemdwmhQh?videoPreview=12025-09-09T13:15:00+00:00700.52Microbiome Virtual International ForumThe preservation of invisible biodiversity, particularly microbial genetic resources, is critical due to their fundamental roles in human health, environmental sustainability, and biotechnological innovation. This analysis highlights the involvement of philanthropic foundations, exemplified by the Seerave Foundation, in supporting initiatives such as the Microbiota Vault, which aims to safeguard microbial diversity threatened by factors including changing lifestyles, climate change, and institutional vulnerabilities like freezer failures or shifting research priorities. The foundation’s engagement is rooted in patient-driven motivations and a scientific focus on the microbiome’s influence on cancer and immune responses. By maintaining close collaboration with scientists and innovators, the foundation facilitates interdisciplinary convening and funding to accelerate research and conservation efforts. Key challenges identified include political inertia, fundraising difficulties, ethical and legal complexities, and the need for global cooperation amid competitive scientific environments. Philanthropic foundations contribute not only financial resources but also strategic networking and neutral platforms that unite diverse stakeholders—researchers, policymakers, and local collections—to advance the initiative’s vision. The experience of the Microbiota Vault demonstrates the importance of early-stage philanthropic risk-taking to catalyze broader support and underscores the necessity of sustained, collaborative efforts to translate visionary goals into practical preservation outcomes. This work calls for expanded donor engagement to ensure the long-term safeguarding of microbial biodiversity essential for health and ecological resilience.https://cassyni-user-files-prod.s3.amazonaws.com/TeRDaZq2W6FoLkTMwdSjkJ https://cassyni.com/events/JFTbMJJmH4YGGicUm2efru/seminar/qa https://cassyni.com/slides/outline/JFTbMJJmH4YGGicUm2efru https://cassyni.com/events/JFTbMJJmH4YGGicUm2efru/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Hn33s3h32fEpJbUe63sNuL https://cassyni.com/events/JFTbMJJmH4YGGicUm2efru?videoPreview=1 Thieme Chemistry Best Paper Awardsnohttps://cassyni.com/events/JFTbMJJmH4YGGicUm2efru?videoPreview=12025-06-12T08:00:00+00:005584.36Thieme GroupIn this Thieme Cheminar, we are excited to welcome the winners of the Best Paper Awards from the journals Synthesis, Synlett, and Organic Materials, who will present their groundbreaking research: - Prof. Kei Murakami (Kwansei Gakuin University) - Prof. Sunkyu Han (Korea Advanced Institute of Science and Technology) - Dr. Jan Freudenberg (Heidelberg University) - Prof. Yota Sakakibara (Kwansei Gakuin University) Join us and discover cutting-edge research in organic synthesis, catalysis, and materials science. Don’t miss the chance to engage with leading experts in the field!https://cassyni-user-files-prod.s3.amazonaws.com/Hn33s3h32fEpJbUe63sNuL https://cassyni.com/events/V7itNLYJw8ijnzSWNZtMoj/abstract https://cassyni-user-files-prod.s3.amazonaws.com/FsTPCVWkEX2WPs5cd1KN3g https://cassyni.com/slides/outline/U8RgGyFG4Dcb8EcWGbR2zq https://cassyni.com/events/U8RgGyFG4Dcb8EcWGbR2zq/abstract https://cassyni-user-files-prod.s3.amazonaws.com/VmQS4B116ANEa681UmV9Je https://cassyni.com/events/U8RgGyFG4Dcb8EcWGbR2zq?videoPreview=1 Preservation of the global early life microbiota: Can a synergism with human milk reveal beneficial strains?nohttps://cassyni.com/events/U8RgGyFG4Dcb8EcWGbR2zq?videoPreview=12025-09-11T02:15:00+00:00712.8Microbiome Virtual International ForumIt is well established that the developing infant gut microbiota influences numerous aspects of later health. During breastfeeding, early-life bifidobacterial populations that grow on milk glycans are associated with improved immune function, reduced gut inflammation, and lower pathogen levels. With weaning, the gut microbiome shifts in composition, driven largely by the introduction of solid foods and the expansion of new microbial groups and functions. Industrialization has been linked to a global decline in early-life bifidobacteria, highlighting the need to understand and preserve the bacterial strains and functions that co-evolved to metabolize milk glycans in the infant gut. In addition to protecting the infant during breastfeeding, introducing keystone bifidobacterial populations into infants who lack them may also help support optimal development during the transition to weaning.https://cassyni-user-files-prod.s3.amazonaws.com/VmQS4B116ANEa681UmV9Je https://cassyni.com/slides/outline/7PCJLG5DczMKzFADzUVh7K https://cassyni.com/events/7PCJLG5DczMKzFADzUVh7K/abstract https://cassyni-user-files-prod.s3.amazonaws.com/5MYjtrtMtkdm1qRe7EMd8A https://cassyni.com/events/7PCJLG5DczMKzFADzUVh7K?videoPreview=1 Bridging Neuroscience and Artificial Intelligence: Deep Learning Models for Understanding Visionnohttps://cassyni.com/events/7PCJLG5DczMKzFADzUVh7K?videoPreview=12025-06-17T16:00:00+00:003534.64NoneNeuroscience and Artificial Intelligence (AI) share a long-standing relationship with each field driving advancements in the other. In this talk, we focus on the intersection of neuroscience and AI through the lens of visual perception, using deep learning models as tools for modeling and understanding rodent and human vision. We begin by modeling the Lateral Geniculate Nucleus (LGN), a key subcortical structure in the visual pathway. Using high-level vision models, we encode LGN neural activity, recorded in vivo from mice, in response to natural scene stimuli. We demonstrate that early layers of deep neural networks (DNNs) accurately represent the LGN activity, and we reveal that numerosity is represented at this early stage of visual processing. Expanding this investigation, we present a large-scale study comparing various DNN architectures with fMRI recordings from human visual regions in response to video stimuli. We show that video-understanding models outperform image-based models and that convolutional models provide better neural representations of early to mid-level visual regions compared to transformer models. Moreover, we introduce a novel neural encoding scheme that incorporates inter- and intra-region connectivity across the visual regions. Overall, in this talk, we highlight the synergy between neuroscience and AI, and we demonstrate how AI can deepen our understanding of visual perception. Taliya Weinstein, Programming Chair of the Data Science for Health in Africa Workshop 2025 from SisonkeBiotik will chair this seminar. Image credit: [v2osk (Unsplash)](https://unsplash.com/photos/macro-photography-of-human-eye-In4XVKhYaiI).https://cassyni-user-files-prod.s3.amazonaws.com/5MYjtrtMtkdm1qRe7EMd8A https://cassyni.com/events/x4epjxSnxGFbNuzPZVu7s/seminar/qa https://cassyni.com/slides/outline/x4epjxSnxGFbNuzPZVu7s https://cassyni.com/events/x4epjxSnxGFbNuzPZVu7s/abstract https://cassyni-user-files-prod.s3.amazonaws.com/GEKSNEjnq1rsAua2PXaH4i https://cassyni.com/events/x4epjxSnxGFbNuzPZVu7s?videoPreview=1 Developing hydrodynamic sensing capabilities for fish-like robotsnohttps://cassyni.com/events/x4epjxSnxGFbNuzPZVu7s?videoPreview=12025-06-24T04:00:00+00:003600.04The Auckland Bioengineering InstituteMaritime Drones, just as their counterparts on land and in the air, are becoming an increasing reality and a field of rapid development. Used for ocean exploration, asset monitoring and harbour security, they withstand high pressures, salt water and rough conditions to provide information and manipulation capabilities. Biomimetic, fish-like robots offer the possibility of silent, agile and energy-efficient locomotion in this domain. To realize their potential of swimming like a fish, sensor systems are needed which provide hydrodynamic information such as flow speed and direction while being able to withstand the demanding oceanic conditions. Existing sensor systems offer high sensitivity, rivalling the biological analogue but face inherent design challenges such as high cost and energy consumption, brittleness and static pressure sensitivity preventing their deployment and proliferation. I hypothesise that these inherent challenges for open ocean deployment in previous hydrodynamic sensor systems for fish-like robots can be overcome through bioinspired capacitance-based designs, providing robust, low-cost blueprints which can be tailored to provide relevant flow information in diverse conditions. Three sensors are developed to validate this hypothesis. The developed sensors based on electroactive polymers are pressure agnostic, physically robust and shielded from electromagnetic interference. A novel membrane-based rheotaxis sensor makes angle-of-attack measurements up to 1 m/s flow speed with a resolution below 5- degrees possible. Furthermore, the possibility of integrating sensing membranes directly into a bionic pectoral fin propulsors, measuring hydrodynamic loading was demonstrated. Lastly, a dorsal fin sensor for detecting cross-body flow along a robotic fish’s spine using solid state fringe-field sensors enabled roll and yaw estimation related to the actual flow. The real-world capabilities of these sensors were successfully tested through high-pressure exposure and longterm salt-water submersion tests. The developed sensors validate the research hypothesis and present a further step in achieving fish-like hydrodynamic sensing capabilities deployable from the depth of the ocean to rivers and mangrove estuaries benefiting research, commercial and security operations.https://cassyni-user-files-prod.s3.amazonaws.com/GEKSNEjnq1rsAua2PXaH4i https://cassyni.com/events/EJGkyq8ZmQ77V49oMv4dG1/seminar/qa https://cassyni.com/slides/outline/EJGkyq8ZmQ77V49oMv4dG1 https://cassyni.com/events/EJGkyq8ZmQ77V49oMv4dG1/abstract https://cassyni-user-files-prod.s3.amazonaws.com/TkA5svgrgeWJBzA7ocuBcz https://cassyni.com/events/EJGkyq8ZmQ77V49oMv4dG1?videoPreview=1 Navigating Towards Net-Zero Flights: The Challenges and Opportunities for Airlinesnohttps://cassyni.com/events/EJGkyq8ZmQ77V49oMv4dG1?videoPreview=12025-06-11T12:00:00+00:003682.92Brahmal Vasudevan Institute for Sustainable AviationThe delivery of net-zero aviation on the front line is the responsibility of aircraft operators, most notably the world’s commercial airline industry. It is airlines that invest in and deploy new technology including more efficient aircraft and sustainable aviation fuels. Airlines also work with the wider aviation system to deliver operational efficiency while experiencing some head winds due to a changing climate. In this seminar, we look at how airlines are prioritising efforts towards i) achieving net-zero emissions by 2050, including the challenges, opportunities and the uncertainties involved. ii) reducing non-carbon emission impacts, including operational and technological mitigation options. iii) assessing the risks and opportunities of climate change, to adapt airlines for better resilience. https://cassyni-user-files-prod.s3.amazonaws.com/TkA5svgrgeWJBzA7ocuBcz https://cassyni.com/events/Bq2jkQtwa7LaStv1u8GGFo/abstract https://cassyni-user-files-prod.s3.amazonaws.com/8LqrUWtrr636xsAnnPfg9c https://cassyni.com/slides/outline/QBGU28awwv7AV3rEA3mS2Z https://cassyni.com/events/QBGU28awwv7AV3rEA3mS2Z/abstract https://cassyni-user-files-prod.s3.amazonaws.com/6X4LKqENQtmrSkHEjp4TvE https://cassyni.com/events/QBGU28awwv7AV3rEA3mS2Z?videoPreview=1 Libraries Under Fire: Defending Scholarship in a Time of Political Pressurenohttps://cassyni.com/events/QBGU28awwv7AV3rEA3mS2Z?videoPreview=12025-07-08T13:30:00+00:003877.04Part of the nonprofit Annual Reviews organizationUnderstanding and addressing the escalating attacks on libraries, government censorship, and the fight for intellectual freedom in the US and how it is changing the research ecosystem worldwide. Image credit: [Florian Wehde (Unsplash)](https://unsplash.com/photos/city-buildings-near-body-of-water-during-daytime-1uWanmgkd5g).https://cassyni-user-files-prod.s3.amazonaws.com/6X4LKqENQtmrSkHEjp4TvE https://cassyni.com/events/4v1XL6sNERSLbUqgw2Mfvu/seminar/qa https://cassyni.com/slides/outline/4v1XL6sNERSLbUqgw2Mfvu https://cassyni.com/events/4v1XL6sNERSLbUqgw2Mfvu/abstract https://cassyni-user-files-prod.s3.amazonaws.com/6cxaitpUq4pHZ26Fkrosin https://cassyni.com/events/4v1XL6sNERSLbUqgw2Mfvu?videoPreview=1 Debate the motion: To improve dialysis patient outcomes, the focus needs to shift from outpatient to inpatient care 1530-1700nohttps://cassyni.com/events/4v1XL6sNERSLbUqgw2Mfvu?videoPreview=12025-09-19T14:30:00+00:002911.36Imperial College Renal and Transplant CentreAnnual gladiatorial clash between two seasoned fighters in opinionhttps://cassyni-user-files-prod.s3.amazonaws.com/6cxaitpUq4pHZ26Fkrosin https://cassyni.com/slides/outline/9Lj4B55e57NUVPJSo9pBiu https://cassyni.com/events/9Lj4B55e57NUVPJSo9pBiu/abstract https://cassyni-user-files-prod.s3.amazonaws.com/8aSANziyagRwEJ4fjjuX7C https://cassyni.com/events/9Lj4B55e57NUVPJSo9pBiu?videoPreview=1 Modelling skeletal muscle for orthopaedic applicationnohttps://cassyni.com/events/9Lj4B55e57NUVPJSo9pBiu?videoPreview=12025-10-28T23:00:00+00:003709.04Auckland Bioengineering InstituteCharacterising the mechanical environment of skeletal tissues is important for understanding injury and disease and critical to designing medical devices or personalising treatment interventions. Neuromusculoskeletal models provide a framework for estimating muscle and joint contact forces that are consistent with observed motion and measured external forces. Skeletal muscles (and tendons) are typically represented as line-segment force actuators when solving multi-body dynamics, using phenomenological, lumped parameters to describe force-length and force-velocity relationships (Hill-type models). However, this approach does not capture the spatial arrangement, fibre orientation and mechanical interactions of muscles with bones and connective tissues. This talk discusses opportunities to improve models of skeletal muscle with application to orthopaedics. https://cassyni-user-files-prod.s3.amazonaws.com/8aSANziyagRwEJ4fjjuX7C https://cassyni.com/slides/outline/Uc3F6MpzbKtoM8U1WQzZN5 https://cassyni.com/events/Uc3F6MpzbKtoM8U1WQzZN5/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Cy3fXxoxcf7DqVNxkcy78a https://cassyni.com/events/Uc3F6MpzbKtoM8U1WQzZN5?videoPreview=1 Non-Traditional (Contingent) Employment Practices Among People with Physical Disabilitiesnohttps://cassyni.com/events/Uc3F6MpzbKtoM8U1WQzZN5?videoPreview=12025-05-30T08:00:00+00:003350.28 School of Public PolicyThis seminar examines non-traditional, or contingent, employment practices among people with physical disabilities, highlighting their growing significance amid persistent barriers in traditional workforce participation. Contingent employment encompasses freelance, contract, temporary, and gig economy work characterized by limited or conditional employer-employee relationships, often lacking long-term job security and benefits. The analysis identifies key motivations for individuals with disabilities to pursue contingent work, including the flexibility to manage pain, fatigue, and caregiving responsibilities, avoidance of disability disclosure, and opportunities for career development through internships or self-directed work. However, contingent employment also presents challenges such as lower pay, absence of workplace accommodations protected under the Americans with Disabilities Act, and limited access to health insurance. The study further explores how assistive technologies and personal networks influence employment experiences, noting differences between individuals with congenital disabilities—who often have greater familiarity and comfort with assistive and mainstream technologies—and those with acquired disabilities, who may face more difficulties integrating technology into their work lives. Through composite personas derived from qualitative interviews, the research illustrates diverse contingent employment trajectories and the role of self-advocacy, technology use, and social capital in navigating these pathways. The findings underscore the complex trade-offs faced by people with physical disabilities in balancing autonomy, financial security, and accessibility, suggesting that contingent employment can serve as both a viable alternative and a transitional strategy within broader efforts to improve inclusive labor market participation.https://cassyni-user-files-prod.s3.amazonaws.com/Cy3fXxoxcf7DqVNxkcy78a https://cassyni.com/slides/outline/7ssXVaEdToq9oi9jnacfHX https://cassyni.com/events/7ssXVaEdToq9oi9jnacfHX/abstract https://cassyni-user-files-prod.s3.amazonaws.com/N7n2Y9twbz6dLzf5GrQGoG https://cassyni.com/events/7ssXVaEdToq9oi9jnacfHX?videoPreview=1 Neural Regulation of Rat Gastric Electrophysiology and Motility: Measurement and Modellingnohttps://cassyni.com/events/7ssXVaEdToq9oi9jnacfHX?videoPreview=12025-07-15T04:00:00+00:002910.36The Auckland Bioengineering InstituteRhythmic contractions of the stomach are governed by electrophysiological slow wave activity and modulated by input from neurons. Disorders of gut-brain interaction are a burden on the lives of patients. Electrical stimulation of the vagus nerve modulates gastric motility, and therapeutic applications could be advantageous for patients with drug-refractory disease. However, the mechanisms through which vagus nerve stimulation (VNS) modifies gastric motility need further investigation. This exit seminar presents complementary experimental and computational research into the role of gastric slow waves in the neural regulation of rat gastric motility. Measurement and analysis methods for rat gastric SWs were validated _in vitro_ and _in vivo_ using simultaneous intracellular and extracellular electrical measurements, and videographic recordings. Slow wave activity was characterised in a baseline state, and the effects of three _in vivo_ cervical VNS protocols on slow waves were quantified. A mathematical cell model was formulated to simulate the effect of enteric neural input on gastric electrophysiology and active tension generation. The model predicted that smooth muscle cell sensitivity to intracellular calcium was the major inhibitory mechanism for contraction amplitude. The cell model was embedded in a whole-organ model of rat gastric SW propagation, which was parameterised to model experimentally measured variation in slow wave characteristics. Outcomes from this thesis are a valuable addition to the corpus of gastrointestinal and autonomic neurophysiology research. Experimental methods and outcomes established a baseline for rat gastric slow wave propagation characteristics that will be useful for future investigations. Experimental and modelling results showed that therapeutic cervical VNS treatments may need to be adjusted in a pathology- or patient-specific manner that accounts for the health of the nervous system. https://cassyni-user-files-prod.s3.amazonaws.com/N7n2Y9twbz6dLzf5GrQGoG https://cassyni.com/slides/outline/4RLJAnhxPbxWn1rB8vEhkh https://cassyni.com/events/4RLJAnhxPbxWn1rB8vEhkh/abstract https://cassyni-user-files-prod.s3.amazonaws.com/5Lszv5apuGGY34z6zTXvVc https://cassyni.com/events/4RLJAnhxPbxWn1rB8vEhkh?videoPreview=1 Bio inspired metallic ceramic non cuttable materialnohttps://cassyni.com/events/4RLJAnhxPbxWn1rB8vEhkh?videoPreview=12022-07-27T12:00:00+00:002852.88UK Metamaterials NetworkThis study explores the development of a bio-inspired metallic ceramic composite designed to resist cutting by angle grinders, motivated by security challenges such as theft prevention. Drawing on natural hierarchical structures—exemplified by abalone shells and other biological materials that combine stiff and soft layers to arrest crack propagation—the material integrates cellular metallic foam with ceramic spheres arranged in a stiff-soft-stiff architecture. Manufacturing involves powder mixing, pressing, and controlled foaming to produce lightweight, complex porous structures. Computational modeling using LS-DYNA addresses the mechanical behavior dominated by plastic buckling of spherical shells, with sensitivity analyses revealing that yield stress governs buckling capacity under temperature variations. Experimental testing demonstrates that when subjected to cutting attempts, the ceramic spheres induce localized vibrations, creating a dynamic resistance mechanism. These vibrations generate a “vibrational interface” analogous to a sandpaper effect that grinds the cutting disk, significantly impeding penetration. High-speed imaging and CT scans confirm partial penetration followed by arrest due to vibrational energy dissipation. The study also revisits classical analyses of rotating disk vibrations, highlighting the interaction of traveling waves and resonance phenomena that underpin the material’s dynamic response. The findings suggest that hierarchical design and local resonance can be harnessed to create lightweight, non-cuttable materials with potential applications in security and protective equipment. Future directions include optimizing hierarchical architectures for multifunctionality, exploring responsive metamaterials, and integrating sustainability considerations inspired by natural material efficiency and recyclability.https://cassyni-user-files-prod.s3.amazonaws.com/5Lszv5apuGGY34z6zTXvVc https://cassyni.com/slides/outline/Enwz99HycDawJX9KA2BbSD https://cassyni.com/events/Enwz99HycDawJX9KA2BbSD/abstract https://cassyni-user-files-prod.s3.amazonaws.com/2RiqrbVZXdbNUJ4KaB7VeW https://cassyni.com/events/Enwz99HycDawJX9KA2BbSD?videoPreview=1 Evolving Cybersecurity - PTaaS and Bug Bounties as Game-Changers in NZnohttps://cassyni.com/events/Enwz99HycDawJX9KA2BbSD?videoPreview=12024-06-18T23:00:00+00:003010.08Business SchoolThe evolving cybersecurity landscape, marked by frequent data breaches and hacker issues in New Zealand, necessitates advanced security testing approaches. Traditional annual penetration testing is often slow, expensive (ranging from NZD $1,500 to $35,000 per engagement), and provides siloed reports, leaving applications vulnerable for extended periods amidst continuous development cycles. A modern approach integrates Penetration Testing as a Service (PTaaS) and bug bounty programs to enhance digital safety. The Capture the Bug platform provides on-demand, scalable, and tailored penetration testing and facilitates bug bounties. It leverages a crowdsourced community of over 3,500 ID-verified security researchers, of whom 500+ have cleared Capture the Flag (CTF) challenges and possess a minimum of three years of industry experience with certifications like CEH, OSCP, and CRTP. This platform enables rapid program launch (within four working days), real-time reporting, and collaboration between testers and developers. It features AI-powered remediation, trained on extensive NIST datasets, to provide immediate, context-based code fixes in specific tech stacks (e.g., PHP), accelerating the patching cycle. Bug bounty programs offer impact-driven rewards, incentivizing researchers to uncover critical vulnerabilities such as XSS, SQL injection, and IOS. New Zealand recently adopted vulnerability disclosure policies (VDPs) in February of the previous year, acknowledging the importance of community reporting. This shift from manual, time-bound testing to a continuous, proactive model significantly reduces the window of exposure, streamlines vulnerability identification and remediation, and ensures compliance with international standards like ISO 27001, SOC 2, and PCI DSS, thereby enhancing overall application security.https://cassyni-user-files-prod.s3.amazonaws.com/2RiqrbVZXdbNUJ4KaB7VeW https://cassyni.com/slides/outline/4QGdps8H5tkuBSiAadhFwj https://cassyni.com/events/4QGdps8H5tkuBSiAadhFwj/abstract https://cassyni-user-files-prod.s3.amazonaws.com/6e6omDMDL6zknBCMpNJZdY https://cassyni.com/events/4QGdps8H5tkuBSiAadhFwj?videoPreview=1 Developing New Approaches to Understand the Microbial Worldnohttps://cassyni.com/events/4QGdps8H5tkuBSiAadhFwj?videoPreview=12026-04-21T01:00:00+00:001826.52Microbiome Virtual International ForumResearch at the Center for Microbiome Research develops new approaches to understand the microbial world, focusing on bioinformatic tools, high-throughput cultivation, and novel visualization techniques. A new bioinformatic tool, RecurM, was developed to identify extrachromosomal elements without relying on known databases, addressing limitations of computational intensity and elusive linear plasmids. Applied to 10,800 human gut metagenomes, RecurM identified 9,212 circular and 34,192 linear elements, with 5,466 determined to be novel (521 viruses, 1,810 plasmids, 3,135 unknown mobile genetic elements). Co-abundance analysis, validated against known plasmids, linked 210 novel plasmids to 100 host species, revealing that most plasmids were unique to individuals. To address the challenge of uncultured microbes, the Australian Human Microbiome Biobank (AHMB) was established, employing fluorescence-activated cell sorting (FACS) in custom anaerobic chambers for single-cell isolation from diverse human body sites. The AHMB has recovered over 25,000 isolates, including bacteria and archaea from 12 phyla and over 650 species, with 37.7% of species and several higher-order taxa brought into culture for the first time. This effort has revealed significant genetic diversity within species, with some pan-genomes having a core genome of less than 10%, indicating that cultured isolates provide essential genetic information. Novel genome-based fluorescence in situ hybridization (GenomeFISH) was developed to overcome limitations of traditional FISH. GenomeFISH couples single-cell genomics with whole-genome hybridization, achieving superior signal strength and strain-level resolution, capable of distinguishing strains with up to 99% Average Nucleotide Identity (ANI). This method was successfully applied to complex bioreactor and human fecal communities, demonstrating its applicability to uncultivated microbes. Further extensions, Plasmid FISH and Virus FISH, enable targeted visualization of mobile genetic elements. Collectively, these integrated approaches provide advanced capabilities for characterizing microbial diversity, function, and interactions within complex communities.https://cassyni-user-files-prod.s3.amazonaws.com/6e6omDMDL6zknBCMpNJZdY https://cassyni.com/slides/outline/9rTwgJpjDe3uuRRy9YUbi5 https://cassyni.com/events/9rTwgJpjDe3uuRRy9YUbi5/abstract https://cassyni-user-files-prod.s3.amazonaws.com/JVy8fFfLiAV4yDMwXbTVw4 https://cassyni.com/events/9rTwgJpjDe3uuRRy9YUbi5?videoPreview=1 Evidence-based solutions for healthier indoor environmentsnohttps://cassyni.com/events/9rTwgJpjDe3uuRRy9YUbi5?videoPreview=12021-04-13T23:00:00+00:002512.08Business SchoolThe increasing amount of time people spend indoors, exceeding 90% of their lives in some regions, highlights a critical disconnect from natural environmental patterns. This contributes to chronic health issues and, as recently observed, can make buildings significant vectors for pathogens. A comprehensive, evidence-based approach has been developed to merge health sciences with building sciences. This involved a $100 million, 4.5-year research effort, leading to the **WELL Building Standard** in 2015, which was medically peer-reviewed by institutions like Cleveland Clinic and Mayo Clinic. This standard, now deployed in 81 countries and covering nearly 2 billion square feet of commercial real estate, examines how elements such as indoor air and water quality, lighting, thermal comfort, acoustics, and biophilic design impact respiratory, cardiovascular, immune, cognitive, digestive, and sleep health outcomes. Further experimental work is conducted at the **Well Living Lab**, a 50/50 collaboration with Mayo Clinic. This living laboratory uses sensory technology to measure up to 200 external environmental inputs and over 1000 internal human biomarkers, enabling comparative analysis (e.g., lighting's impact on sleep, particulates on cognition). Findings indicate indoor air quality is often 2-5 times worse than outdoors, and up to 70% of chronic health outcomes are determined by environmental and social conditions. The incremental cost for WELL Certified Platinum construction is less than 1%. Additionally, the **WELL Health-Safety Rating** was introduced to certify operational health and safety protocols, now adopted in 74 countries. The overarching aim is to shift from humans adapting to their environment, to environments adapting to human needs, leveraging real estate as a passive, preventative healthcare intervention with significant economic and societal benefits.https://cassyni-user-files-prod.s3.amazonaws.com/JVy8fFfLiAV4yDMwXbTVw4 https://cassyni.com/slides/outline/HGDdVC3VCsHUYUeqPzGmkh https://cassyni.com/events/HGDdVC3VCsHUYUeqPzGmkh/abstract https://cassyni-user-files-prod.s3.amazonaws.com/F2QLgP8CCAXaRY4MT2rCGv https://cassyni.com/events/HGDdVC3VCsHUYUeqPzGmkh?videoPreview=1 Honeycomb structures perturbed along irrational edgesnohttps://cassyni.com/events/HGDdVC3VCsHUYUeqPzGmkh?videoPreview=12025-06-16T07:00:00+00:001500.24ETOPIMIn this work, we study wave propagation in two-dimensional continuous honeycomb structures with a line defect. We focus on a Schr¨odinger operator H := −∆ +Q(x) in R2 with a perturbed honeycomb potential, where the perturbation consists of a transition, along an edge, between two distinct parity-breaking periodic structures. For edges with rational slopes, the perturbed medium remains translation-invariant along the edge. In this case, prior work has established the existence of edge states, namely time-harmonic solutions of the corresponding wave equation, that propagate along the edge and decay in the transverse direction. For irrational slopes, however, the lack of translation invariance along the edge makes the very definition of edge states nontrivial. Our approach relies on the observation that the perturbed potential is quasiperiodic along irrational edges, meaning it can be viewed as a slice of a 3D potential with translation-invariance in the direction of the edge. This property allows us to embed our problem in a higher-dimensional framework, defining edge states as restrictions of solutions to an augmented 3D degenerate Schrödinger eigenvalue problem. Using this framework, we construct a family of approximate solutions to the augmented Schr¨odinger eigenvalue problem that propagate along the edge and decay in the transverse direction. The asymptotic behavior of these approximate edge states is governed by 1D effective Dirac operators. Unlike for rational edges, the asymptotic analysis leads to infinitely many effective Dirac operators, resulting in infinitely many linearly independent solutions.https://cassyni-user-files-prod.s3.amazonaws.com/F2QLgP8CCAXaRY4MT2rCGv https://cassyni.com/slides/outline/KjTeicH7QA3xuR8PwgBQUd https://cassyni.com/events/KjTeicH7QA3xuR8PwgBQUd/abstract https://cassyni-user-files-prod.s3.amazonaws.com/9LwteXBf9QATCBAZbMG91g https://cassyni.com/events/KjTeicH7QA3xuR8PwgBQUd?videoPreview=1 Interface effects in flatland opticsnohttps://cassyni.com/events/KjTeicH7QA3xuR8PwgBQUd?videoPreview=12025-06-17T05:00:00+00:002024.04ETOPIMControlling surface-wave propagation at the nanoscale remains a key challenge in modern photonics and nanotechnology. A particularly intriguing class of surface waves, line waves, propagate along the junction between surfaces with different impedances, exhibiting strong energy confinement in both in-plane and out-of-plane directions [1,2]. Unlike conventional surface waves, which spread across a two-dimensional (2D) interface, line waves confine electromagnetic energy to a one-dimensional (1D) path, making them highly attractive for applications in integrated waveguides, optical sensing, and sub-diffraction imaging. This work explores how engineered planar impedance discontinuities can give rise to novel wave phenomena inspired by their higher-dimensional counterparts. Specifically, we introduce ghost line waves, flat leaky waves, and scale-invariant flat waveguiding, each offering unique mechanisms for manipulating light at the nanoscale. Ghost line waves emerge at isotropic-anisotropic interfaces with a tilted optical axis, exhibiting oscillatory decay both in-plane and out-of-plane, unlike conventional line waves that decay monotonically. This behavior is reminiscent of ghost waves and ghost surface polaritons observed in anisotropic media [3]. Flat leaky waves, on the other hand, extend the properties of standard line waves by enabling in-plane leaky-wave radiation while maintaining strong out-of-plane confinement [4], akin to 2D Cherenkov radiation [5]. Finally, scale-invariant flat waveguiding provides a new mechanism for light confinement, analogous to conventional dielectric waveguides [6], where wave propagation is maintained at the transition between flatland leakage and a bound surface mode, ensuring an effective index independent of the core width. This presentation will discuss both theoretical and computational challenges, along with experimental validations using microwave demonstrators. These results highlight the potential of impedance-engineered surfaces for advancing flat optics and wave-based nanophotonic technologies. https://cassyni-user-files-prod.s3.amazonaws.com/9LwteXBf9QATCBAZbMG91g https://cassyni.com/slides/outline/Y5fkshTENbtpo6NCv2k8cm https://cassyni.com/events/Y5fkshTENbtpo6NCv2k8cm/abstract https://cassyni-user-files-prod.s3.amazonaws.com/GdEYoc3wCtRAFa4ozA2DW6 https://cassyni.com/events/Y5fkshTENbtpo6NCv2k8cm?videoPreview=1 How fast does the edge spin current flow?nohttps://cassyni.com/events/Y5fkshTENbtpo6NCv2k8cm?videoPreview=12025-06-19T01:00:00+00:001097.2ETOPIMTopologically nontrivial band structure of a two-dimensional electronic material may give rise to edge states at its boundaries that are robust with respect to disorder and scattering. These edge states are at the origin of quantum Hall effects (QHE), including the quantum spin Hall (QSHE) and quantum anomalous Hall (QAHE) effects, manifesting themselves in quantized values of electrical conductance [1]. Recent technologies allow for visualizing current flows inside a two-dimensional material with spatial resolution and provide elements of the answer to a long-standing question of “where does the current flow” [2]. In the present work, we use a microwave platform that mimics QSHE to explore the time-domain, QSHE-specific counterpart of this question: “how fast does the edge spin current flow”? Our experiment exploits the idea of Wu and Hu [3] allowing for simulating QSHE with electromagnetic waves by making the orbital angular momentum of light in hexagonal clusters of dielectric cylinders to play the role of electron spin. We construct a sample made of two topologically distinct parts by arranging clusters of two different sizes in a triangular lattice, see Fig. 1. Electromagnetic waves are excited along the interface between the two parts of the sample and transport of angular momentum (or pseudospin) along the interface is measured with both spatial and temporal resolution [4]. Our measurements allow for determining the velocity of pseudospin transport and comparing it to the group velocity of microwaves. Both velocities turn out to be equal and 2 to 3 orders of magnitude slower than the speed of light in the free space, which may limit performance of photonic devices that use topologically protected edge states for transmission, storage or processing of information. Note that the breakdown of lattice symmetry near an edge spoils the analogy between the optical angular momentum and electron spin, preventing the spectral gap from closing. This flaw can be exploited to realize a unidirectional wave propagation despite the preserved time-reversal symmetry of our experimental setup. In Fig. 1, for example, an isotropic antenna excites an electromagnetic wave along the horizontal interface between the two topologically distinct parts of the sample (bold red arrows) but not along the interface between the sample and the air surrounding it. “Switching” propagation from one interface to another can be achieved by tuning the frequency of the signal, allowing for new opportunities in routing of electromagnetic waves in photonic circuits. https://cassyni-user-files-prod.s3.amazonaws.com/GdEYoc3wCtRAFa4ozA2DW6 https://cassyni.com/slides/outline/SeY7NBLTYZokQE7yK7kLdK https://cassyni.com/events/SeY7NBLTYZokQE7yK7kLdK/abstract https://cassyni-user-files-prod.s3.amazonaws.com/5dorXPuWST6ZxcPZR2hwMp https://cassyni.com/events/SeY7NBLTYZokQE7yK7kLdK?videoPreview=1 Moire platforms beyond TMDs and graphenenohttps://cassyni.com/events/SeY7NBLTYZokQE7yK7kLdK?videoPreview=12025-06-18T23:00:00+00:003632.48ETOPIMMoiré systems, formed by stacking and twisting two-dimensional materials, provide a versatile platform for engineering novel electronic Hamiltonians with strong interactions and tunable kinetic energy scales. This analysis explores the realization of flat bands and correlated phases beyond well-studied graphene and transition metal dichalcogenides (TMDs), emphasizing the potential to design arbitrary Hamiltonians through moiré engineering. The study elucidates the origin of flat bands in bipartite lattices such as kagome structures, where destructive quantum interference leads to rank-deficient coupling matrices and zero-energy modes. In twisted bilayer graphene near the magic angle, the moiré superlattice drastically reduces bandwidths from electron-volt to millielectron-volt scales, enhancing interaction effects and enabling the observation of correlated insulators and superconductivity at integer fillings. A detailed theoretical framework decomposes the flat bands into localized “f-electron” Wannier orbitals and dispersive “c-electron” bands, revealing a novel heavy-fermion–like model with strong Coulomb interactions predominantly on localized states. Dynamical mean-field theory (DMFT) calculations predict a new state of matter characterized by a Mott insulating gap coexisting with topological semimetallic features, confirmed by recent momentum-resolved scanning tunneling microscopy experiments. Extending beyond graphene, the approach highlights the vast unexplored landscape of twisted van der Waals materials with diverse symmetry points (e.g., M point) and lattice types, where moiré-induced flat bands exhibit distinct topological and interaction-driven phenomena. The emergence of effectively one-dimensional coupled spin models in certain valleys suggests rich correlated phases accessible via controlled twisting and gating, positioning moiré platforms as a fertile ground for discovering and manipulating exotic quantum states.https://cassyni-user-files-prod.s3.amazonaws.com/5dorXPuWST6ZxcPZR2hwMp https://cassyni.com/slides/outline/5uJjRUAR7LYVGEfh2zpzjo https://cassyni.com/events/5uJjRUAR7LYVGEfh2zpzjo/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Fbwor5QwnBFjPmX3vAvFrN https://cassyni.com/events/5uJjRUAR7LYVGEfh2zpzjo?videoPreview=1 Underground biological internet: common mycelial networks in inter-plant signalling and resistance to pathogensnohttps://cassyni.com/events/5uJjRUAR7LYVGEfh2zpzjo?videoPreview=12025-07-09T12:00:00+00:001749.04NoneArbuscular mycorrhizal fungi (AMF) like _Rhizophagus irregularis_ form common mycelial networks (CMN) that interconnect multiple plant hosts, potentially serving as a conduit for inter-plant signal exchange (communication) that may influence stress responses in receivers. We investigate the impact of known plant defence elicitors on pathogen tolerance of plants receiving signals via CMN by analysing leaf metabolites, emitted volatiles, and transcriptome data. We found that the integrity of the CMN significantly shapes the responses of signal-receiving plants, with distinct changes in defence-related transcripts and plant isoprenoids, including volatile monoterpenes and triterpene saponins. Additionally, plants receiving signals through intact CMN from stressed donor plants exhibit increased resistance to _Fusarium sporotrichoides_ and heightened susceptibility to _Botrytis cinerea_. Our findings emphasize the role of CMN in shaping plant responses to pathogens and suggest that the mechanisms of inter-plant signalling may influence genetic regulation of defence priming, offering new insights into plant–pathogen interactions. Our research utilizes not only model species _Medicago truncatula_ and _Daucus carota_ but extends to characterisation of inter-tree responses in hybrid aspen and silver birch. We further aim to explore the regional endemic diversity of AMF towards prospective agricultural applications for enhancement of community level resistance in different crops and tree species. https://cassyni-user-files-prod.s3.amazonaws.com/Fbwor5QwnBFjPmX3vAvFrN https://cassyni.com/events/Qet2qXAgV2PNiFHaMhxHcy/seminar/qa https://cassyni.com/slides/outline/Qet2qXAgV2PNiFHaMhxHcy https://cassyni.com/events/Qet2qXAgV2PNiFHaMhxHcy/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Lp3fnFwB33vTs6S9inYN9L https://cassyni.com/events/Qet2qXAgV2PNiFHaMhxHcy?videoPreview=1 From Physics-Informed Machine Learning to Physics-Informed Machine Intelligence: Quo Vadimus?nohttps://cassyni.com/events/Qet2qXAgV2PNiFHaMhxHcy?videoPreview=12025-09-29T13:00:00+00:004225.56ArtIStE - Artificial Intelligence in Structural EngineeringThis talk reviews physics-informed neural networks and introduces networks that learn functionals and nonlinear operators for system identification. It discusses applications in digital twins, autonomy, and materials discovery, and introduces bio-inspired solutions like spiking neural networks and neuromorphic computing. https://cassyni-user-files-prod.s3.amazonaws.com/Lp3fnFwB33vTs6S9inYN9L https://cassyni.com/slides/outline/KiPzNghS6SrMK9aEMEFHtq https://cassyni.com/events/KiPzNghS6SrMK9aEMEFHtq/abstract https://cassyni-user-files-prod.s3.amazonaws.com/EtjeagZuS9GdmN1nm3QX58 https://cassyni.com/events/KiPzNghS6SrMK9aEMEFHtq?videoPreview=1 Mechanical Computing: Elastic Waves that Compute and Multitasknohttps://cassyni.com/events/KiPzNghS6SrMK9aEMEFHtq?videoPreview=12025-10-14T13:00:00+00:004099.04MetaMATMechanical intelligence has gained prominence in recent years due to advances in metamaterials and fabrication techniques, providing analog computing mechanisms with self-embedded sensory and actuation capabilities. Owing to their physical nature, such systems achieve a level of autonomy, through thermal, acoustic, and mechanical forms of material response, that enable them to seamlessly integrate with surrounding environments. Most of the early efforts in this space have relied on static and quasi-static deformations, infusing elements of bi-stability, buckling, and employing origami concepts to create logic gates and mechanical bits. In this talk, we provide an overview of distinct classes of wave-based mechanical computers that leverage the rich dynamics of periodic and phononic metamaterials, while integrating mechanical memory and thermal adaptivity within the computing system. We demonstrate that these systems can undertake high-order computations such as differentiation and convolution or embody mechanical intelligence by realizing physical neural architectures. We will show how to exploit dynamically modulated metasurfaces to unlock parallel processing of incident information and simultaneously conduct independent tasks within the same elastic medium via frequency multiplexing. Finally, we will shed light on a class of multifunctional mechanical computing circuits that incorporate memory-integrated components, configured via shape-memory alloy (SMA)-based metamaterial cells, which trigger specific actions upon thermal activation. These systems lay the foundation for substantial advancements and new paradigms in the mechanical, acoustic and optical domains, which thus far have been elusive in physical and non-digital computing systems.https://cassyni-user-files-prod.s3.amazonaws.com/EtjeagZuS9GdmN1nm3QX58 https://cassyni.com/slides/outline/T8844wQJgKABoj6hK772Jq https://cassyni.com/events/T8844wQJgKABoj6hK772Jq/abstract https://cassyni-user-files-prod.s3.amazonaws.com/5n5vkom5khwfG3aM4QPwpa https://cassyni.com/events/T8844wQJgKABoj6hK772Jq?videoPreview=1 The teen brain: Mysteries and misconceptionsnohttps://cassyni.com/events/T8844wQJgKABoj6hK772Jq?videoPreview=12023-04-27T06:00:00+00:003807.24Part of the nonprofit Annual Reviews organizationA conversation about the teenage brain’s strengths and vulnerabilities, how adults can support teenagers with mental health issues, and how teens can help one another.https://cassyni-user-files-prod.s3.amazonaws.com/5n5vkom5khwfG3aM4QPwpa https://cassyni.com/events/DHy8moHcPVeiAYdzQRkca1/seminar/qa https://cassyni.com/slides/outline/DHy8moHcPVeiAYdzQRkca1 https://cassyni.com/events/DHy8moHcPVeiAYdzQRkca1/abstract https://cassyni-user-files-prod.s3.amazonaws.com/7rdtWSjVuE1zUuzQwQrAKp https://cassyni.com/events/DHy8moHcPVeiAYdzQRkca1?videoPreview=1 Hierarchical Assembly of Microtubule Matternohttps://cassyni.com/events/DHy8moHcPVeiAYdzQRkca1?videoPreview=12025-10-16T14:00:00+00:004330.68Journal of Biological PhysicsThe fundamental organizational principles used by the cell to organize its interior space is still not fully elucidated. Two important mechanisms for cellular self-organization include liquid-liquid phase separation of protein species to form membraneless organelles and self-organization of cytoskeletal filaments into larger-scale arrangements such as the actin cortex and microtubule mitotic spindle. We have observed that the microtubule-crosslinking proteins, MAP65 and PRC1, can self-assemble into liquid-like condensates that can catalyze spatially controlled nucleation and growth of microtubule asters with control over the aster organization. Microtubules grown from gel-like condensates can reverse the gelation, controlling the material properties. This interplay between protein condensates and the cytoskeleton could allow for dynamic reorganization of the cell interior in space and time.https://cassyni-user-files-prod.s3.amazonaws.com/7rdtWSjVuE1zUuzQwQrAKp https://cassyni.com/events/NgKEmR6U8Z6iAmoXc8Ad5F/seminar/qa https://cassyni.com/slides/outline/NgKEmR6U8Z6iAmoXc8Ad5F https://cassyni.com/events/NgKEmR6U8Z6iAmoXc8Ad5F/abstract https://cassyni-user-files-prod.s3.amazonaws.com/BoKrg1ZB3zYvnHLV4Amxce https://cassyni.com/events/NgKEmR6U8Z6iAmoXc8Ad5F?videoPreview=1 Crazy Dice, Chance, and Counting Causesnohttps://cassyni.com/events/NgKEmR6U8Z6iAmoXc8Ad5F?videoPreview=12025-10-29T15:00:00+00:004197.04Logica UniversalisWe develop a simple model of the underdetermination of theory by data using “crazy dice” – standardly shaped dice with non-standard labellings – and we use the model to illustrate a number of distinct ways that scientific data (the probability distributions of the dice) can underdetermine our theories of that data (claims about the shapes, labellings, number, and identity of the dice). We conclude by drawing some tentative conclusions regarding what this model has to teach us about the underdetermination of theory by data in general.https://cassyni-user-files-prod.s3.amazonaws.com/BoKrg1ZB3zYvnHLV4Amxce https://cassyni.com/slides/outline/PAxqp6jza1emAYLRCZTRLZ https://cassyni.com/events/PAxqp6jza1emAYLRCZTRLZ/abstract https://cassyni-user-files-prod.s3.amazonaws.com/U3CByVgXHGCUqXzDDwzxWA https://cassyni.com/events/PAxqp6jza1emAYLRCZTRLZ?videoPreview=1 How spatial and temporal climate changes over deep time have influenced global plant diversitynohttps://cassyni.com/events/PAxqp6jza1emAYLRCZTRLZ?videoPreview=12025-08-05T14:00:00+00:00829.8NoneBiodiversity loss and climate change are interlinked global challenges. Climate impacts on biodiversity are often explained through spatial factors such as climatic area or isolation, or temporal factors such as climatic antiquity and stability. However, the combined influence of spatial and temporal climatic dynamics remains unknown. Here, we integrate both dimensions to assess how the long-term geographic extent and shift of climates have shaped global plant diversity. By compiling occurrence records for 350,864 vascular plant species, we produce the most comprehensive and precise global plant diversity map to date. We identify climatic analogues spanning tens of millions of years and quantify their geographic dynamics over deep time. Incorporating spatio-temporal climate changes into statistical models explains up to 92% of the deviance in present-day global plant diversity. Our findings extend previous hypotheses by showing that plant diversity is higher in climatic conditions that have stayed widespread over deep time. We also reveal a novel mechanism: climates that have expanded and shifted moderately in space over deep time foster higher diversity by balancing persistence with diversification. By revealing spatio-temporal climate influences on biodiversity, our study informs conservation strategies that conserve ancient biodiversity in stable climates while supporting ongoing diversification under climate change.https://cassyni-user-files-prod.s3.amazonaws.com/U3CByVgXHGCUqXzDDwzxWA https://cassyni.com/events/HjqCJadDjyZgmg6BbeTdM7/seminar/qa https://cassyni.com/slides/outline/HjqCJadDjyZgmg6BbeTdM7 https://cassyni.com/events/HjqCJadDjyZgmg6BbeTdM7/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Sbjpr6Cr3NTeGzF1Bm4HXU https://cassyni.com/events/HjqCJadDjyZgmg6BbeTdM7?videoPreview=1 24th international Biometals webinarsnohttps://cassyni.com/events/HjqCJadDjyZgmg6BbeTdM7?videoPreview=12026-03-03T14:00:00+00:003655.48BioMetalsThe global challenge of antimicrobial resistance necessitates novel therapeutic strategies. This study explores the potential of metal-based drugs, particularly bismuth and gold compounds, to disrupt metallostasis in bacterial and viral pathogens. Bismuth compounds were found to restore antibiotic activity against multidrug-resistant bacteria, including those producing metallo-β-lactamases (NDM-1, VIM-2, IMP-4). Mechanistically, bismuth(III) displaces zinc from the active site of NDM-1, with one equivalent of bismuth replacing two equivalents of zinc, leading to irreversible enzyme inhibition exceeding 90%. Similarly, gold(I) compounds, such as Auranofin, targeted the zinc-binding domain of MCR-1, an enzyme conferring colistin resistance, thereby restoring antibiotic efficacy. *In vivo* models demonstrated that combination therapy with bismuth or gallium drugs significantly reduced bacterial load by 2-3 log units and increased survival rates to 75-100% in resistant bacterial infections. Furthermore, bismuth was shown to disrupt iron homeostasis in bacteria, interfering with iron-related proteins and iron-sulfur clusters. Beyond bacteria, bismuth compounds inhibited viral helicase activity by targeting zinc-finger domains, suppressing viral load in infected animal models and reducing the duration of viral infection in small-scale clinical trials by 1-3 days compared to conventional antivirals, especially when co-administered with N-acetyl-L-cysteine to enhance absorption. These findings highlight the disruption of metal homeostasis as a promising strategy for combating both antimicrobial resistance and viral infections.https://cassyni-user-files-prod.s3.amazonaws.com/Sbjpr6Cr3NTeGzF1Bm4HXU https://cassyni.com/events/GkT7sKnWeyfzFRVMMKRpAy/seminar/qa https://cassyni.com/slides/outline/GkT7sKnWeyfzFRVMMKRpAy https://cassyni.com/events/GkT7sKnWeyfzFRVMMKRpAy/abstract https://cassyni-user-files-prod.s3.amazonaws.com/5Pm51hT4vgipBthvdAqRZp https://cassyni.com/events/GkT7sKnWeyfzFRVMMKRpAy?videoPreview=1 From Head to Toe and many things in between.nohttps://cassyni.com/events/GkT7sKnWeyfzFRVMMKRpAy?videoPreview=12025-08-12T04:00:00+00:003588.36The Auckland Bioengineering InstituteIn this talk I will reflect on my academic journey so far. Through a series of examples I will showcase what keeps me excited and why, the rewards of being a little daring in your research, learning to be comfortable with setbacks, and the benefits of surrounding yourself with great students, colleagues, and networks.https://cassyni-user-files-prod.s3.amazonaws.com/5Pm51hT4vgipBthvdAqRZp https://cassyni.com/events/W63JTfoLiRQYfMKza12MVF/seminar/qa https://cassyni.com/slides/outline/W63JTfoLiRQYfMKza12MVF https://cassyni.com/events/W63JTfoLiRQYfMKza12MVF/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Mm75TuSvz3v5zgPu5pJT4r https://cassyni.com/events/W63JTfoLiRQYfMKza12MVF?videoPreview=1 Identification of non-smooth dynamical systems by data-driven techniquesnohttps://cassyni.com/events/W63JTfoLiRQYfMKza12MVF?videoPreview=12025-11-20T14:30:00+00:002654.56Nonlinear Dynamics, an International Journal of Nonlinear Dynamics and Chaos in Engineering Systems**Abstract**: Non-smooth mechanical systems frequently describe very complex dynamical behaviors, and so are very subtle to manage. On top of that, quite often the mechanical behaviour lurking in the background it not fully understood, since it may involve a lot of nonlinear phenomena that are overlooked and treated in approximate phenomenological way. This is quite different from smooth systems, where the underlying basic governing law are known to an adequate extent. Therefore, they represent examples in which data-driven techniques can really help to understand the mechanics which is behind the dynamical outcome, not only providing a model but hopefully giving knowledge, and so being very beneficial. A technique recently developed, that is based on a well-known free software for data-driven analysis, is illustrated. **Key Learning Objectives** • Realizing the lack of knowledge that we can have on some non-smooth systems • Developing a technique for non-smooth systems identification • Extending the use of SINDy software, which is well known and performant for smooth systems • Learning the physical behaviours that are behind some non-smooth systems **Who Should Attend** • Mechanical engineers • Civil engineers • Researchers/scientists in dynamical systems • Practitioners dealing with non-smooth systems • PhD students dealing with nonlinear dynamicshttps://cassyni-user-files-prod.s3.amazonaws.com/Mm75TuSvz3v5zgPu5pJT4r https://cassyni.com/events/YZHKh62xuiB32HoZ7gvzDB/seminar/qa https://cassyni.com/slides/outline/YZHKh62xuiB32HoZ7gvzDB https://cassyni.com/events/YZHKh62xuiB32HoZ7gvzDB/abstract https://cassyni-user-files-prod.s3.amazonaws.com/C9aBVHqhZBXZXtUXZonCd4 https://cassyni.com/events/YZHKh62xuiB32HoZ7gvzDB?videoPreview=1 Discovery and Engineering of Inflammation-Nanomodulators for Disease Therapynohttps://cassyni.com/events/YZHKh62xuiB32HoZ7gvzDB?videoPreview=12026-04-14T11:00:00+00:002963.6The Pharmacological Research family of journalsInflammation is a process closely associated to the development and progression of various diseases, such as cancer and rheumatoid arthritis (RA). Modulating local and systemic inflammation can reprogram the immune microenvironment and improve therapeutic outcomes, yet developing safe and effective immunomodulators remains challenging. Given the ubiquitous presence and critical roles of macrophages across various diseases, they represent an accessible target for immunomodulator discovery. Our work focuses on identifying small-molecule agonists/inhibitors for macrophage reprogramming and rationally engineering polysaccharide immunomodulators to enhance disease therapy. We have developed a high-throughput phenotypic screening platform using a macrophage phenotype-specific nanoprobe (MPSNPr) to identify small-molecule agonists and inhibitors from traditional Chinese medicine that reprogram macrophage polarization. Two lead candidates were rationally engineered into polysaccharide immunomodulators, Dex-BA and Dex-SAL, which amplify macrophage reprogramming efficacy in vitro and in vivo. In a mouse melanoma model, Dex-BA promotes macrophage M1 polarization, dendritic cell maturation, and cytotoxic T cell activation, thereby inhibiting tumor growth. In rheumatoid arthritis (RA), Dex-SAL reprograms activated macrophages toward an anti-inflammatory phenotype, reversing the immune microenvironment and alleviating disease symptoms. Furthermore, the functional properties of these polysaccharide immunomodulators can be tuned to enhance therapeutic outcomes. This work establishes a robust platform for discovering novel immunomodulators and demonstrates their rational engineering for improved disease therapy.https://cassyni-user-files-prod.s3.amazonaws.com/C9aBVHqhZBXZXtUXZonCd4 https://cassyni.com/slides/outline/QACogD1GeCuYtUiDbmDzDb https://cassyni.com/events/QACogD1GeCuYtUiDbmDzDb/abstract https://cassyni-user-files-prod.s3.amazonaws.com/5JZ82pULSd1mJ2Dt5RrUeA https://cassyni.com/events/QACogD1GeCuYtUiDbmDzDb?videoPreview=1 Curriculum Mapping for Medical Educationnohttps://cassyni.com/events/QACogD1GeCuYtUiDbmDzDb?videoPreview=12025-02-26T09:00:00+00:002626.92AAMCJoin us this February 2025 for an insightful workshop on Curriculum Mapping for Medical Education! In this session, we will cover the fundamentals of curriculum mapping, its value, key features, and roles and responsibilities within institutions. This session will also equip attendees with tools to effectively map curricula, ensuring alignment with accreditation standards and institutional goals. Engage in interactive discussions on accreditation, CQI, tracking curriculum strands/threads, transitioning systems, and the role of AI in curriculum mapping. Enhance your skills in curriculum mapping to improve medical education programs. This webinar is part of the Building Better Curriculum Series, hosted by the AAMC. For more information on the complete series, see the [series webpage](https://www.aamc.org/about-us/mission-areas/medical-education/curriculum-resources/establish-your-ci/webinars).  https://cassyni-user-files-prod.s3.amazonaws.com/5JZ82pULSd1mJ2Dt5RrUeA https://cassyni.com/slides/outline/Jj5AAgtVpApUVcTyzrECE9 https://cassyni.com/events/Jj5AAgtVpApUVcTyzrECE9/abstract https://cassyni-user-files-prod.s3.amazonaws.com/XB8QxqksyH2Tb6hm8ZJee2 https://cassyni.com/slides/outline/KDimDNY2FdNXVNzsbHWzVT https://cassyni.com/events/KDimDNY2FdNXVNzsbHWzVT/abstract https://cassyni-user-files-prod.s3.amazonaws.com/CSFg3Cuy28rp36j2yEYj4a https://cassyni.com/events/KDimDNY2FdNXVNzsbHWzVT?videoPreview=1 Should We Engineer the Genomes of Our Children? Navigational Policymaking in the New Genetic Eranohttps://cassyni.com/events/KDimDNY2FdNXVNzsbHWzVT?videoPreview=12007-04-07T08:00:00+00:004653.44 School of Public PolicyThe prospect of genetically engineering human embryos raises profound ethical and policy challenges that demand careful consideration within pluralistic democratic societies. This analysis explores potential applications of genetic engineering, including therapeutic interventions to eliminate disease predispositions, enhancements of cognitive and temperamental traits, aesthetic modifications such as skin pigmentation, and longevity extension. These possibilities blur traditional distinctions between therapy and enhancement, complicating policy frameworks. The complexity and novelty of genetic engineering exemplify what is termed “fractious problems,” characterized by scientific uncertainty, ethical depth, societal divisiveness, and unavoidable public concern. Such problems resist resolution through conventional top-down policy debates, which often become entrenched in polarized positions grounded in conflicting foundational beliefs. To address these challenges, a navigational approach to policymaking is proposed, emphasizing incremental, context-sensitive decision-making informed by past precedents, future scenario imagining, interdisciplinary expertise, and shared democratic principles such as liberty, equality, and welfare. This approach advocates moving from broad principle-driven disputes to concrete, manageable policy issues, allowing for iterative refinement over time. It recognizes the tension between individual parental choice and communitarian interests, the evolving nature of ethical norms (e.g., definitions of child abuse), and the social implications of genetic modifications. The navigational framework aims to facilitate progress in policymaking by fostering dialogue grounded in diverse perspectives and practical wisdom, thereby enabling societies to adapt responsively to the evolving landscape of human genetic engineering.https://cassyni-user-files-prod.s3.amazonaws.com/CSFg3Cuy28rp36j2yEYj4a https://cassyni.com/slides/outline/S8oDrwbNQ38JzBzSxj5ve9 https://cassyni.com/events/S8oDrwbNQ38JzBzSxj5ve9/abstract https://cassyni-user-files-prod.s3.amazonaws.com/B8uMYb3YxXbrDhyTPJQuG2 https://cassyni.com/events/S8oDrwbNQ38JzBzSxj5ve9?videoPreview=1 Creative Insecurity: Can Trump’s Trade Threats Jolt Canada Into Action?nohttps://cassyni.com/events/S8oDrwbNQ38JzBzSxj5ve9?videoPreview=12025-05-28T08:00:00+00:003645.36 School of Public PolicyThis seminar examines the role of “creative insecurity” as a driver of national innovation, focusing on Canada’s current challenges amid external economic and political pressures, notably from U.S. trade threats under the Trump administration. The analysis foregrounds the thesis that countries experiencing external threats—military, economic, or geopolitical—are more likely to mobilize resources and political will to innovate, whereas internal divisions tend to inhibit such efforts. Drawing on comparative examples including Israel, South Korea, Taiwan, Japan, and China, the discussion highlights how perceived vulnerabilities have historically catalyzed sustained innovation through targeted industrial policies and public-private collaboration. Canada’s innovation ecosystem, despite strengths in fundamental research and education, is characterized by insufficient translation of scientific advances into commercial innovation, partly due to complacency, fragmented federal-provincial governance, and a lack of coordinated industrial strategy. The Trump-era trade tensions have generated a renewed sense of national urgency and patriotism in Canada, creating a potential window for more intentional, large-scale industrial policy focused on advanced sectors such as energy technology, biotechnology, and agtech. However, challenges remain in overcoming entrenched political economy dynamics, including divergent regional interests and underinvestment by private firms. The seminar underscores the necessity of aligning competitive markets with strategic government support to foster innovation, while cautioning that innovation requires societal willingness to accept short-term sacrifices for long-term gains. Emerging technologies like AI may decentralize innovation but also require balanced regulatory approaches. The Canadian case illustrates the complex interplay between external threats, political cohesion, and innovation policy effectiveness in advanced economies.https://cassyni-user-files-prod.s3.amazonaws.com/B8uMYb3YxXbrDhyTPJQuG2 https://cassyni.com/slides/outline/5PZqvERKxos3rCYAgcAakd https://cassyni.com/events/5PZqvERKxos3rCYAgcAakd/abstract https://cassyni-user-files-prod.s3.amazonaws.com/6URwfkekmQcCKBjrDQ96Ln https://cassyni.com/events/5PZqvERKxos3rCYAgcAakd?videoPreview=1 How Do Scientists Think? Creative Proccesses in Conceptual Innovationnohttps://cassyni.com/events/5PZqvERKxos3rCYAgcAakd?videoPreview=12010-08-23T08:00:00+00:004630.76 School of Public PolicyThe seminar explores the cognitive and creative processes underlying scientific conceptual innovation, emphasizing the significance of creativity in advancing science and technology. It situates the investigation within the broader context of how scientific thinking adapts and evolves in response to technological developments and cultural implications. The approach involves philosophical analysis of scientific reasoning, drawing on expertise in the philosophy of science to elucidate mechanisms by which scientists generate novel concepts and frameworks. The discussion highlights the role of interdisciplinary mentorship and academic lineage in shaping innovative thought, as exemplified by connections between scholars in the field. Although specific empirical methods or case studies are not detailed, the seminar underscores the importance of fostering environments that support creative intellectual inquiry in scientific disciplines. The implications point toward enhancing institutional strategies to cultivate leadership in both scientific research and reflective thinking about science’s societal impact, thereby promoting a more integrated understanding of creativity’s role in scientific progress.https://cassyni-user-files-prod.s3.amazonaws.com/6URwfkekmQcCKBjrDQ96Ln https://cassyni.com/slides/outline/EmtKoDiJJWPKhx1Jbje9dF https://cassyni.com/events/EmtKoDiJJWPKhx1Jbje9dF/abstract https://cassyni-user-files-prod.s3.amazonaws.com/9phYw6BQktb2WoyouVTi1C https://cassyni.com/events/EmtKoDiJJWPKhx1Jbje9dF?videoPreview=1 Cosmic-ray transport and feedback in star-forming environmentsnohttps://cassyni.com/events/EmtKoDiJJWPKhx1Jbje9dF?videoPreview=12024-04-11T06:00:00+00:003302.88Journal of Plasma PhysicsIn recent years, there has been a growing interest in understanding the role of cosmic rays (CRs) in shaping galaxy evolution. MHD galaxy simulations including CRs have demonstrated that CRs can significantly contribute to the dynamics of the interstellar medium (ISM), aiding in the internal support against gravity and helping to launch galactic outflows. However, the degree to which CRs influence these phenomena is highly contingent upon the chosen CR transport prescription within the model. To address this issue, we have recently developed a transport prescription that is grounded in physical principles rather than empirical considerations, aiming for a more realistic representation of CR transport in ISM simulations. In my talk, I will outline the novelty of our model and discuss the implications of adopting this more realistic formulation for CR transport. Furthermore, I will present the application of our novel scheme in MHD simulations of galactic outflows. These simulations reveal that CRs efficiently accelerate extra-planar material if the latter is mostly warm gas, while they have very little effect on fast, hot outflows.https://cassyni-user-files-prod.s3.amazonaws.com/9phYw6BQktb2WoyouVTi1C https://cassyni.com/slides/outline/FGXvquMpjxwNhiYCCAvwtZ https://cassyni.com/events/FGXvquMpjxwNhiYCCAvwtZ/abstract https://cassyni-user-files-prod.s3.amazonaws.com/9aNkQkMeYAJygKLFeisSjQ https://cassyni.com/events/FGXvquMpjxwNhiYCCAvwtZ?videoPreview=1 Plasma Physics at the higher energy and QED frontiernohttps://cassyni.com/events/FGXvquMpjxwNhiYCCAvwtZ?videoPreview=12023-11-16T06:00:00+00:002968.84Journal of Plasma PhysicsPlasma physics generally involves well-known physics of electromagnetism, special relativity and statistical mechanics. Various descriptions of the plasma state (kinetic, fluid, MHD) have been developed and each of them have a specific scope that depends on time/length scales, chemical composition, density, and temperature. Whereas these descriptions are well established, we could wonder when quantum electrodynamics (QED) comes into play. The answer lies in the threshold of QED cross sections which become non negligible for certain critical lengths, energies and fields. The presence of ultra-strong electromagnetic field and relativistic temperatures modifies the underlying basic physics to such a great extent that relying on classical plasma physics is often not justified. The zoo of QED processes implies emission of hard photons, photon-lepton collisions, non-constant number of particles (creation and annihilation), stochastic particle orbits, which have stimulated the community for constructing a QED-based plasma physics. While the state of development of QED-based plasma physics theory is still far from being as mature as that of the classical plasma theory, lots of progresses in this area has been achieved in the past few decades. These advances have implications in many astrophysical and laboratory scenarios (associated to new PetaWatt class lasers), that share common underlying microphysics and collective plasma effects associated with intense fields. This new physics is highly nonlinear and multi scale, and require a combination of theory and large scale numerical simulations. The main challenges in this area with be presented and the recent progresses triggered by large scale simulations of compact objects and of multi dimensional laser/beam-plasma interactions in the presence of fields close to the critical Schwinger field will be discussed, emphasising the interplay between collective plasma dynamics and QED phttps://cassyni-user-files-prod.s3.amazonaws.com/9aNkQkMeYAJygKLFeisSjQ https://cassyni.com/slides/outline/NBe1c6w4HjctMJp1p23eu3 https://cassyni.com/events/NBe1c6w4HjctMJp1p23eu3/abstract https://cassyni-user-files-prod.s3.amazonaws.com/UGCQ1TooyPA2SZdhewjcCe https://cassyni.com/events/NBe1c6w4HjctMJp1p23eu3?videoPreview=1 How can the Humanities and Social Sciences contribute to the Peace Agenda?nohttps://cassyni.com/events/NBe1c6w4HjctMJp1p23eu3?videoPreview=12022-09-21T09:00:00+00:003602.96Palgrave MacmillanThis seminar explores the critical contributions of the humanities and social sciences (HSS) to the global peace agenda amid contemporary crises. It foregrounds the interdisciplinary nature of HSS disciplines—encompassing political science, sociology, history, economics, and cultural studies—and their collective capacity to interrogate conflict, peacebuilding, and social transformation. The discussion highlights challenges such as epistemic biases rooted in colonial histories, the commodification of knowledge, and structural inequalities that marginalize diverse voices, particularly from the Global South and indigenous communities. Emphasis is placed on decolonizing methodologies, fostering inclusivity and equity in research and publishing, and amplifying grassroots perspectives to enrich peace and conflict studies. The role of publishers in Southeast Asia and the Pacific is examined, noting efforts to engage early career researchers, navigate political sensitivities, and broaden access to diverse narratives. The seminar also addresses the dual potential of social sciences and humanities to both perpetuate and resolve conflict, underscoring the ethical imperative to resist capture by corporate and political interests. Contemporary global issues such as the Ukraine war, climate change, and the COVID-19 pandemic are analyzed through HSS lenses, revealing their multifaceted social, economic, and ideological dimensions. The necessity for scholars to transcend academic isolation, communicate complex ideas accessibly, and actively engage with affected communities is underscored. Ultimately, the seminar advocates for a reimagined HSS role that embraces intellectual wisdom, interdisciplinarity, and human agency to contribute meaningfully to peace, justice, and sustainable development.https://cassyni-user-files-prod.s3.amazonaws.com/UGCQ1TooyPA2SZdhewjcCe https://cassyni.com/slides/outline/R9ZFzqL6KqsXGFceZXKMm7 https://cassyni.com/events/R9ZFzqL6KqsXGFceZXKMm7/abstract https://cassyni-user-files-prod.s3.amazonaws.com/G611Nkm3AQaGLtykCkW3Vg https://cassyni.com/events/R9ZFzqL6KqsXGFceZXKMm7?videoPreview=1 Startups to watch – Innovators of tomorrownohttps://cassyni.com/events/R9ZFzqL6KqsXGFceZXKMm7?videoPreview=12026-01-14T12:30:00+00:003423.2Academic Publishing in EuropeThe seminar presented three innovative startups addressing critical challenges in scholarly publishing. Pure.Science introduces an agentic workflow platform designed to enhance publisher operations by enabling the creation and orchestration of flexible, AI-powered workflows. This platform facilitates bespoke solutions for various publishing functions, from typesetting to editorial triage, integrating publishing-specific tools and ensuring auditable, deterministic steps. Its flexible, composable, and integrable architecture allows for rapid prototyping and seamless scaling into production systems, empowering publishers to adapt quickly to evolving landscapes. Global Campus focuses on improving peer reviewer recruitment, a persistent challenge for publishers, funders, and universities. Leveraging OpenAlex, a rich, open dataset, the platform employs AI transformer models to perform high-quality semantic matching between manuscripts and potential reviewers. This approach aims to reduce out-of-field rejections and provide a more diverse pool of experts, with its intuitive interface designed for seamless integration into existing submission workflows. Publishing Gateway offers an institutionally-driven, publisher-neutral platform to provide greater control and transparency over research outputs. It streamlines the article submission process for researchers through a single, standardised workflow, conducting initial integrity checks and peer review. AI tools then match quality-checked manuscripts to suitable journals in a marketplace, offering publishers pre-vetted submissions and enabling institutions to gain earlier financial oversight and process efficiency for their publishing activities.https://cassyni-user-files-prod.s3.amazonaws.com/G611Nkm3AQaGLtykCkW3Vg https://cassyni.com/slides/outline/HF9y9GTouA5rxD6foYLfAu https://cassyni.com/events/HF9y9GTouA5rxD6foYLfAu/abstract https://cassyni-user-files-prod.s3.amazonaws.com/M2aBd33ityhnrRVoHBgNwx https://cassyni.com/events/HF9y9GTouA5rxD6foYLfAu?videoPreview=1 Where is RobotGPT?nohttps://cassyni.com/events/HF9y9GTouA5rxD6foYLfAu?videoPreview=12025-10-09T19:00:00+00:004058.44AI Institute in Dynamic SystemsThe last years have seen astonishing progress in the capabilities of generative AI techniques, particularly in the areas of language and visual understanding and generation. Key to the success of these models are the use of image and text data sets of unprecedented scale along with models that are able to digest such large datasets. We are now seeing the first examples of leveraging such models to equip robots with open-world visual understanding and reasoning capabilities. Unfortunately, however, we have not achieved the RobotGPT moment; these models still struggle with reasoning about geometry and physical interactions in the real world, resulting in brittle performance on seemingly simple tasks such as manipulating objects in the open world. A crucial reason for this problem is the lack of data suitable to train powerful, general models for robot decision making and control. In this talk, I will discuss approaches to generating large datasets for training robot manipulation capabilities, with a focus on the role simulation can play in this context. I will show some of our prior work, where we demonstrated robust sim-to-real transfer of manipulation skills trained in simulation, and then present a hierarchical model architecture that combines high-level, semantic, open-world reasoning, with low-level 3D robot policies. I will conclude with a discussion of future directions for a more scientific investigation of foundation models for robot manipulation.https://cassyni-user-files-prod.s3.amazonaws.com/M2aBd33ityhnrRVoHBgNwx https://cassyni.com/slides/outline/5tF55YajodLsfy7XSYttA1 https://cassyni.com/events/5tF55YajodLsfy7XSYttA1/abstract https://cassyni-user-files-prod.s3.amazonaws.com/D665V2UhDpknubZMBU5HQ https://cassyni.com/events/5tF55YajodLsfy7XSYttA1?videoPreview=1 How to Change Behavior During a Pandemic: From Personal Habits to Public Healthnohttps://cassyni.com/events/5tF55YajodLsfy7XSYttA1?videoPreview=12021-01-15T06:00:00+00:003611.4Part of the nonprofit Annual Reviews organizationSocial distancing. Mask wearing. Vaccine acceptance and uptake. The pandemic may be medical in nature, but many of the public health tools we’ve used to combat the virus, and the tools we’ll need to eradicate it, are behavioral. Adopting these public health behaviors en masse is anything but straightforward, though critical to protecting essential workers and other vulnerable people. Shelter-in-place orders and masks have divided us, often along political lines. We’ve heard pleas to adhere to public health recommendations and witnessed protests against them, as well as fatigue. Why has collective behavior change in the name of saving lives been so hard and felt so personal? And we’re not only grappling with new public health behaviors. With the New Year, many still have individual goals — eat healthier, exercise more, be better partners and parents. Can people achieve personal behavior change, set new habits and chart out new routines at a time when our "normal" world is turned upside down? Join a discussion about the science of behavior change during Covid-19, with behavioral scientist Katherine Milkman (Penn) and social neuroscientist Jay Van Bavel (NYU). The speakers will share their insights on topics like vaccine uptake, the polarization of social distancing and mask-wearing, and how each of us can carve out a place for personal development even in the middle of a pandemic. Milkman recently led a nationwide study on how to boost flu vaccine uptake, and she’s also explored the ways we can use behavioral science to better achieve our goals, through creative techniques like temptation bundling and temporal landmarks. Van Bavel recently coauthored a study on how the social and behavioral sciences can support our response to the pandemic and has been investigating the roots of polarization and our political beliefs for over a decade. Evan Nesterak, Editor in Chief of Behavioral Scientist magazine, will moderate.https://cassyni-user-files-prod.s3.amazonaws.com/D665V2UhDpknubZMBU5HQ https://cassyni.com/slides/outline/2Rhqkm44jRUEeGoxntWvdB https://cassyni.com/events/2Rhqkm44jRUEeGoxntWvdB/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Nx5xQmf2qk864ENAFSrP4a https://cassyni.com/events/2Rhqkm44jRUEeGoxntWvdB?videoPreview=1 The Influence of Patient and Physician Race-Related Attitudes and Perceptions on Nonverbal Synchrony in Oncology Treatment Interactions Between Black Patients and Non-Black Physiciansnohttps://cassyni.com/events/2Rhqkm44jRUEeGoxntWvdB?videoPreview=12025-10-03T10:28:35+00:001432.16Sage PublishingIntroduction: Abundant research documents Black-White disparities in the quality of patient-physician clinical communication during oncology interactions. Prior research shows that Black patients’ and non-Black physicians’ race-related attitudes and perceptions influence clinical communication and patient and physician perceptions of one another. The aim of this cross-sectional study was to determine the effects of such attitudes and perceptions on another important but understudied aspect of interpersonal communication—nonverbal synchrony. The attitudes and perceptions included non-Black physician implicit racial bias; and Black patients’ suspicion of medical care Black patients receive, trust in healthcare systems, and previous experience with discrimination. We predicted that patient and physician race-related attitudes and perceptions would be associated with various nonverbal synchrony measures during oncology interactions between Black patients and non-Black physicians. Methods: This was a secondary analysis of video-recorded cancer treatment discussions between Black patients and their non-Black physicians collected as part of a larger study. Participants included 66 Black patients and 13 non-Black physicians. Physician implicit racial bias and demographic characteristics and Black patient race-related attitudes, perceptions, and demographic characteristics were assessed prior to the interactions. Using automated motion energy analysis software, we evaluated three measures to examine nonverbal synchrony: 1) global nonverbal synchrony, 2) patient-led nonverbal synchrony, and 3) physician-led nonverbal synchrony. Results: We found positive relationships between physicians’ implicit racial bias and all measures of nonverbal synchrony. We found a positive relationship between one patient attitude (trust in healthcare systems) and one nonverbal synchrony measure (patient-led nonverbal synchrony). Conclusions: Findings provide evidence of a link between Black patient and non-Black physician race-related attitudes and perceptions and their jointly determined nonverbal synchrony during clinical interactions. Further work is needed to understand the nuances and clinical implications of this complicated relationship, and to inform potential interventions to improve communication quality and related patient outcomes. https://cassyni-user-files-prod.s3.amazonaws.com/Nx5xQmf2qk864ENAFSrP4a https://cassyni.com/slides/outline/4twrzBHgviEj1DHXLaRZM7 https://cassyni.com/events/4twrzBHgviEj1DHXLaRZM7/abstract https://cassyni-user-files-prod.s3.amazonaws.com/HJNR7SG3n6zLhseqaQobTt https://cassyni.com/events/4twrzBHgviEj1DHXLaRZM7?videoPreview=1 The fluid dynamics of infections: from science to policynohttps://cassyni.com/events/4twrzBHgviEj1DHXLaRZM7?videoPreview=12024-01-25T06:00:00+00:002795.16Leeds Institute for Fluid DynamicsOver the course of the pandemic we became acutely aware of the role that the environment plays in transmission of respiratory diseases, and how our interactions in indoor spaces determine the risk of infection. Understanding the routes of transmission is challenging, but modelling of aerosols, droplets and indoor airflows can play an important role in identifying mechanisms and determining mitigations. However, this mechanistic approach is only one part of a complex picture, and successful management of a respiratory disease is also significantly influenced by human behaviour, organisational strategy and policy choices. Tackling the pandemic rapidly needed evidence to support national and international decisions, and the response pulled scientists worldwide into rapid research as well as supporting communication of evidence. In this talk I will give an insight into airborne disease and the importance of the physics of transmission in understanding practical mitigations such as ventilation controls. I will also reflect on the contribution of research into providing evidence to policy and public engagement during this period and how this influences the research we do going forward. https://cassyni-user-files-prod.s3.amazonaws.com/HJNR7SG3n6zLhseqaQobTt https://cassyni.com/slides/outline/TcoHEFZiX8e1dC6D7DDzV3 https://cassyni.com/events/TcoHEFZiX8e1dC6D7DDzV3/abstract https://cassyni-user-files-prod.s3.amazonaws.com/21FGBJjTJRQ4KX4JynMjqg https://cassyni.com/events/TcoHEFZiX8e1dC6D7DDzV3?videoPreview=1 Infrastructure Sustainability: Finding Common Ground: Finding Shared Challenges and Complementary Strengths Across Open Science Infrastructure Stakeholdersnohttps://cassyni.com/events/TcoHEFZiX8e1dC6D7DDzV3?videoPreview=12026-02-25T16:15:00+00:002901.24Researcher to ReaderA critical challenge in today’s funding landscape is building sustainable partnerships across seemingly opposing stakeholders. Public funding alone is insufficient, and over-reliance on single stakeholders puts critical systems at risk. Through interactive discussion, the panellists will examine their own biases and discover they may be closer to other stakeholders than initially thought. By analysing real-world examples, we will explore how different motivations can become complementary strengths. The goal is to model the kind of honest conversations different stakeholders need to have more often and identify practical ways to collaborate more effectively. https://cassyni-user-files-prod.s3.amazonaws.com/21FGBJjTJRQ4KX4JynMjqg https://cassyni.com/events/8MWiRbLFQH38rc3iBudgnq/seminar/qa https://cassyni.com/slides/outline/8MWiRbLFQH38rc3iBudgnq https://cassyni.com/events/8MWiRbLFQH38rc3iBudgnq/abstract https://cassyni-user-files-prod.s3.amazonaws.com/UMy6BnFGEUCRHDn1SYNqoU https://cassyni.com/events/8MWiRbLFQH38rc3iBudgnq?videoPreview=1 On contrail cirrus lifetimesnohttps://cassyni.com/events/8MWiRbLFQH38rc3iBudgnq?videoPreview=12025-11-18T11:30:00+00:003807.48Brahmal Vasudevan Institute for Sustainable AviationThis talk presents a process-based investigation of lifetime statistics of persistent contrails and contrail cirrus clouds based on an idealized dynamical microphysical model. Cloud lifetimes are estimated by tracking the microphysical evolution of a cirrus layer that evolves in a large-scale ice-supersaturated area driven by a prescribed dynamical forcing. Special emphasis is given to the crucial role of internal high frequency gravity waves in affecting cirrus lifecycles. Simulated lifetime statistics are compared with satellite observations and categorized into three distinct evolutionary regimes. A parallel is drawn to cold cirrus at the tropical tropopause, for which unequivocal observational evidence is available, and implications for future contrail research are discussed.https://cassyni-user-files-prod.s3.amazonaws.com/UMy6BnFGEUCRHDn1SYNqoU https://cassyni.com/events/2vP4v5DUaEx4TjoUazdtoP/seminar/qa https://cassyni.com/slides/outline/2vP4v5DUaEx4TjoUazdtoP https://cassyni.com/events/2vP4v5DUaEx4TjoUazdtoP/abstract https://cassyni-user-files-prod.s3.amazonaws.com/CDqGxuLWegXk4HAoNNSNBG https://cassyni.com/events/2vP4v5DUaEx4TjoUazdtoP?videoPreview=1 Listening to the Body’s Signals: Engineering Insights into Sleep and Brain Disordersnohttps://cassyni.com/events/2vP4v5DUaEx4TjoUazdtoP?videoPreview=12025-12-09T03:00:00+00:003530.64The Auckland Bioengineering InstituteOur bodies continuously generate complex electrical and physiological signals that quietly encode valuable information about our health. Advances in biomedical signal processing now allow us to “listen” to these hidden codes—revealing patterns that traditional clinical assessments may overlook. This talk will explore two major applications of such signal decoding: (1) detecting and characterizing sleep apnea through breathing sounds analysis, and (2) using Electrovestibulography (EVestG) to identify neural signatures associated with neurodegenerative and mental disorders. By integrating engineering innovations with clinical insight, these studies demonstrate how signal processing can transform raw physiological data into actionable diagnostic knowledge, paving the way for earlier detection and more personalized interventions in sleep and brain health.https://cassyni-user-files-prod.s3.amazonaws.com/CDqGxuLWegXk4HAoNNSNBG https://cassyni.com/events/LD6qedNjLdFwxK2NM1CRyw/seminar/qa https://cassyni.com/slides/outline/LD6qedNjLdFwxK2NM1CRyw https://cassyni.com/events/LD6qedNjLdFwxK2NM1CRyw/abstract https://cassyni-user-files-prod.s3.amazonaws.com/L4Ro8L31FfPFBfucNrBDwt https://cassyni.com/events/LD6qedNjLdFwxK2NM1CRyw?videoPreview=1 A Spotlight on Women in Fluid Dynamics in the UKnohttps://cassyni.com/events/LD6qedNjLdFwxK2NM1CRyw?videoPreview=12026-03-05T13:00:00+00:003606.04Journal of Fluid MechanicsThis seminar will feature the UK Fluids Network Women in Fluid Dynamics UK Special Interest Group (SIG) and several invited speakers. There is currently a substantial underrepresentation of women in fluid dynamics at all career stages, and this SIG will provide a space to network, raise the profile of women across the breadth of fluid dynamics, support career development, be a voice for the community and to funders, and ultimately be a platform to enhance wider aspects of diversity in fluid dynamics.https://cassyni-user-files-prod.s3.amazonaws.com/L4Ro8L31FfPFBfucNrBDwt https://cassyni.com/slides/outline/MCQ3jzfnDYN6d4rNSyfknq https://cassyni.com/events/MCQ3jzfnDYN6d4rNSyfknq/abstract https://cassyni-user-files-prod.s3.amazonaws.com/L8RHVH1me1iKXeY9eTKYn2 https://cassyni.com/events/MCQ3jzfnDYN6d4rNSyfknq?videoPreview=1 How to publish a journal article: An APA Journals webinar for Indonesian scholars nohttps://cassyni.com/events/MCQ3jzfnDYN6d4rNSyfknq?videoPreview=12026-01-19T10:00:00+00:003369.52NoneAn interactive webinar featuring insights on how to publish a journal article, geared specifically toward scholars in Indonesia. Dr. Laura Taylor, Editor of APA's Peace and Conflict: Journal of Peace Psychology, will share her expertise and provide tips for international authors. Image credit: [Shane Ryan Herilalaina (Unsplash)](https://unsplash.com/photos/young-woman-working-on-a-laptop-surrounded-by-plants-N9zoS5-DzkY).https://cassyni-user-files-prod.s3.amazonaws.com/L8RHVH1me1iKXeY9eTKYn2 https://cassyni.com/events/WaiXcyxkZEtNUpKWN79KfT/seminar/qa https://cassyni.com/slides/outline/WaiXcyxkZEtNUpKWN79KfT https://cassyni.com/events/WaiXcyxkZEtNUpKWN79KfT/abstract https://cassyni-user-files-prod.s3.amazonaws.com/NRgCwcv8Rif6SRNCxcHCtv https://cassyni.com/events/WaiXcyxkZEtNUpKWN79KfT?videoPreview=1 When Clean-Looking Water Is Still Toxic: From Microbial Ecology to Circular Treatment Technologiesnohttps://cassyni.com/events/WaiXcyxkZEtNUpKWN79KfT?videoPreview=12026-09-16T10:00:00+00:002882.0ElsevierIndustrial wastewater remains poorly monitored and inadequately managed within the global water cycle. The 2024 UN-Water assessment covered 22 countries, representing 8% of the global population, and reported that 38% of industrial wastewater was treated and 27% safely treated. Textile wet processing is a major contributor, consuming more than five trillion litres of water annually and accounting for nearly 20% of industrial water pollution. Azo dyes dominate textile colouration because of their versatility, colour range, stability, and low cost; however, reductive cleavage can convert them into colourless aromatic amines with ecotoxic and genotoxic effects. Adsorption and sedimentation may further transfer contaminants between water and sediment rather than eliminate them. Current treatment technologies include coagulation–flocculation, adsorption, advanced oxidation, biological processes, and hybrid systems, yet performance is often judged by decolorization, parent-compound disappearance, and chemical oxygen demand reduction. These endpoints do not demonstrate mineralization, biological safety, or transformation-product fate. This study evaluates three transitions: from removal to mineralization; from monocultures to functionally complementary communities; and from chemical endpoints to toxicological and ecological verification. Evidence integrates plant peroxidases, aromatic-amine-degrading consortia, microalgal–bacterial mutualism, water–sediment microcosms, and sequential anaerobic–aerobic microbial–algal fuel cells. A consortium achieved 95% mineralization of 4-nitroaniline and 80% reduction of Acid Black 1 with lower phytotoxicity and cytogenotoxicity, whereas Acid Orange 7 decolorization coincided with severe microbial and functional losses. We propose a six-criterion framework encompassing contaminant removal, transformation-product mineralization, toxicity reduction, microbial-function recovery, resource efficiency, and prevention of residual and cross-compartment pollution, supporting SDG Targets 6.3, 6.6, 3.9, 9.4, and 12.4.https://cassyni-user-files-prod.s3.amazonaws.com/NRgCwcv8Rif6SRNCxcHCtv https://cassyni.com/slides/outline/X5N8ffcGzhSRUarPxYS7vm https://cassyni.com/events/X5N8ffcGzhSRUarPxYS7vm/abstract https://cassyni-user-files-prod.s3.amazonaws.com/JapTj9zsR6LRncUtSg5wPU https://cassyni.com/events/X5N8ffcGzhSRUarPxYS7vm?videoPreview=1 High-order moment closures for partially-ionized reacting plasmasnohttps://cassyni.com/events/X5N8ffcGzhSRUarPxYS7vm?videoPreview=12026-02-26T16:00:00+00:003253.4Journal of Plasma PhysicsPartially ionized plasmas frequently exhibit strong non-equilibrium distribution functions due to inelastic collisions with the neutral species as well as the presence of strong electric fields and spatial gradients. This non-equilibrium state often lies beyond the scope of classical transport models based on the Chapman-Enskog method (e.g., Fick’s, Ohm's or Fourier’s laws). In this work, we investigate high-order moment models to capture the non-equilibrium state with a macroscopic set of equations. In this presentation, we will present a comparison between different high-order moment closures for ions and electrons in partially-ionized plasmas. In particular, we will compare a classical moment closure (based on a Hermite polynomial expansion), a closure based on entropy maximization, and closures based on the quadrature method of moments. In the presentation, we will describe the derivation of the collisional source terms in the moment equations with the Boltzmann operator (including reactions and inelastic processes) as well as we will analyse the consequences of the non-equilibrium in the transport of species. The numerical solution of the high-order moment models will be benchmarked to kinetic simulations of an argon plasma at different pressure regimes, from nearly collisionless to collisionally-dominated in a bounded plasma. https://cassyni-user-files-prod.s3.amazonaws.com/JapTj9zsR6LRncUtSg5wPU https://cassyni.com/events/ReEVA9VWAfMM5icAMdSKwK/seminar/qa https://cassyni.com/slides/outline/ReEVA9VWAfMM5icAMdSKwK https://cassyni.com/events/ReEVA9VWAfMM5icAMdSKwK/abstract https://cassyni-user-files-prod.s3.amazonaws.com/2Su5SEWEqwwjD5L44jZyux https://cassyni.com/events/ReEVA9VWAfMM5icAMdSKwK?videoPreview=1 Asymptotic homogenization for dynamic and buckling analysis of a ladder beamnohttps://cassyni.com/events/ReEVA9VWAfMM5icAMdSKwK?videoPreview=12026-03-03T14:00:00+00:003708.04MetaMATThis talk is dedicated to the long and short-wavelength behaviours of reticulated elastic periodic structures. By means of an asymptotic approach implemented using a multi-cells approach, we derive (i) the equations governing the large scale modulations, (ii) the specific features of the modulation propagation, and (iii) the domain of validity of the description. This approach provides specific information on the physics of large scale modulations that is not directly accessible from the Bloch wave decomposition nor from a multi-scattering approach. The theoretical formulation enables (i) the identification of the frequency range for which evolutions of the rapidly oscillating wave motions arise over long distances, and (ii) simple calculation of the high-frequency wave field based on a two-step procedure that separate the (multi-) cell and the large modulation scales. The asymptotic method is illustrated by studying the academic case of a 1D spring-mass chain. This allows us to establish the correspondence between the modulation phenomena and the classical approaches of homogenization and Floquet–Bloch waves. High-frequency modulations in reticulated ladder beams are then investigated. The dispersion equation for longitudinal and transversal vibrations are first established. Then, from the asymptotic analysis, the equations governing the structure behavior in the standard homogenization regime and in the modulation regimes are derived. In a second part, this talk addresses the determination of buckling loads and mode shapes for a family of ladder beams in the context of plane displacements. The original contributions are: (i) the ability to consider different stiffness ratios between the elements of the structure, (ii) the derivation of effective beam models whose parameters depend on the prestress, (iii) the consideration of both symmetric or asymmetric loadings, and (iv) formulations with mono- or multi-cell periodicity, enabling the identification of both short- and long-wavelength buckling modes. Experiments conducted on 3D-printed ladder beams confirmed the buckling modes and loads predicted by the analytical models. These models are also validated against finite element calculations.https://cassyni-user-files-prod.s3.amazonaws.com/2Su5SEWEqwwjD5L44jZyux https://cassyni.com/slides/outline/9q6S5TaJUxfJhbdYT1cHxH https://cassyni.com/events/9q6S5TaJUxfJhbdYT1cHxH/abstract https://cassyni-user-files-prod.s3.amazonaws.com/HVAJ2ZpdSHrq8sfetpvt5t https://cassyni.com/events/9q6S5TaJUxfJhbdYT1cHxH?videoPreview=1 Session 2A: Hydrogen from Natural Gas (Methane)nohttps://cassyni.com/events/9q6S5TaJUxfJhbdYT1cHxH?videoPreview=12025-10-20T23:30:00+00:005723.04Centre for Energy TechnologyMethane pyrolysis for hydrogen production is critical for decarbonization efforts, provided that the co-produced solid carbon can be separated affordably and valorized at scale. Studies demonstrate the potential of molten metal alloy catalysts operating in bubble column reactors, achieving industrial-relevant productivities (10⁻⁵ to 10⁻⁶ mol/s/cm³). Key catalytic mechanisms involve surface segregation and surface charge distribution, with electronic effects significantly influencing C–H and C–O bond activation rates. For instance, copper-indium alloys are shown to catalyze the formation of multi-walled carbon nanotubes (CNTs) from nanodroplets, with subsequent heat treatment enabling effective catalyst removal. Another approach, utilizing floating-catalyst gas-phase reactors with iron and sulfur precursors and gas recycling, has demonstrated net hydrogen production (84.5 vol% H₂) alongside CNTs. Significant advances in post-processing have led to CNT fibers with tensile strengths exceeding 8 GPa and recent reports of electrical conductivity surpassing copper and aluminum, making them competitive with high-end carbon fibers. Reactor productivity has increased 100-fold, though further optimization of catalyst selectivity and residence time is needed to prevent undesirable radial growth and ensure high-quality product. For industrial-scale application, a non-catalytic methane pyrolysis process aims for cost parity with steam methane reforming (SMR) coupled with carbon capture, utilization, and storage (CCUS). While initial Gen 1 reactors demonstrated hydrogen and carbon yields, achieving consistent commercial-grade carbon black requires improved reactor temperature and retention time control. New Gen 2 reactor architectures are being developed to increase hydrogen capacity and ensure consistent carbon quality. Overall, the economic viability and scalability of methane pyrolysis are contingent on developing robust carbon valorization pathways, with new markets beyond traditional carbon black, such as in construction materials, advanced conductors, and aerospace composites, being essential for accommodating the substantial volumes of carbon produced. Considerations for the long-term fate of carbon and the reduction of upstream fugitive methane emissions are also critical for the overall environmental impact.https://cassyni-user-files-prod.s3.amazonaws.com/HVAJ2ZpdSHrq8sfetpvt5t https://cassyni.com/events/QeaBabVw44CP6h3KFd26Sy/seminar/qa https://cassyni.com/slides/outline/QeaBabVw44CP6h3KFd26Sy https://cassyni.com/events/QeaBabVw44CP6h3KFd26Sy/abstract https://cassyni-user-files-prod.s3.amazonaws.com/TkVZFUsVWyd1vCbiRF7q4a https://cassyni.com/events/QeaBabVw44CP6h3KFd26Sy?videoPreview=1 Introducing the Research Talks Showcase: a case study with GA Tech Carter School of Public Policynohttps://cassyni.com/events/QeaBabVw44CP6h3KFd26Sy?videoPreview=12026-02-03T14:00:00+00:002464.04CassyniEvery year, more than a million research talks are held. This should be the world's richest source of research information, but it is lost. Cassidy and the [GA Tech Carter School](https://cassyni.com/s/gatech-carter) challenged Cassyni to help them to find records of the talks their faculty have presented around the globe over the last 5 years and to help faculty to keep a record going forward. In this seminar, Andrew will introduce the technology Cassyni has built to capture and structure these talks, turning them into a key research output and unlocking a foundational source of research knowledge. We will discuss what we found, and how the Carter School is using the Showcase that Cassyni created to recruit potential students and faculty, provide information about their research to researchers and policy makers, and more.https://cassyni-user-files-prod.s3.amazonaws.com/TkVZFUsVWyd1vCbiRF7q4a https://cassyni.com/slides/outline/HEr7tLo4UBtsLerQhTQTzu https://cassyni.com/events/HEr7tLo4UBtsLerQhTQTzu/abstract https://cassyni-user-files-prod.s3.amazonaws.com/3wRyLpzEGNYzVhg4T3NfZY https://cassyni.com/events/HEr7tLo4UBtsLerQhTQTzu?videoPreview=1 Why Headaches Are Everyone’s Business: Health, Work, and Inequality on the Global Stage (Session 1 - Suitable for Asian and Oceania time zones)nohttps://cassyni.com/events/HEr7tLo4UBtsLerQhTQTzu?videoPreview=12026-03-27T07:00:00+00:004463.76The Journal of Headache and PainMigraine and headache disorders are among the world’s most common yet overlooked health challenges, with profound effects on wellbeing, productivity, and equality. This multi‑regional webinar brings together experts from around the globe to explore how reframing migraine as a major global health issue can drive progress toward the UN Sustainable Development Goals (SDGs).Rational Approach to Migraine: A Brain-Capital Imperative for Global Action Migraine is far more than a headache — it is a chronic brain condition that silently affects hundreds of millions of people worldwide, particularly across the Asia–Oceania region. Despite its enormous burden, migraine remains under-recognised, underdiagnosed, and undertreated, leading to profound consequences for individuals, families, and societies. This webinar reframes migraine through a powerful new lens: brain capital — the cognitive, emotional, and creative capacity that drives human potential and economic productivity. When migraine is neglected, it erodes learning, decision-making, workforce participation, and innovation, ultimately undermining progress across multiple United Nations Sustainable Development Goals, including health, education, gender equity, and economic growth. Drawing on global clinical experience and policy engagement, this session presents a practical, scalable, and equity-focused approach to migraine care. It highlights how simple, cost-effective strategies — early diagnosis, structured care pathways, non-pharmacological interventions, and rational use of therapies — can significantly reduce disability and improve quality of life, even in resource-limited settings. Importantly, the webinar calls for a shift from fragmented, reactive care to an integrated brain-health approach, embedding migraine into primary care, workforce policy, and universal health coverage. This is not just a clinical challenge — it is a strategic, economic, and moral imperative. Addressing migraine effectively is an investment in healthier individuals, stronger communities, and more resilient societies. The time to act is now.https://cassyni-user-files-prod.s3.amazonaws.com/3wRyLpzEGNYzVhg4T3NfZY https://cassyni.com/slides/outline/SdAbmL62otR9CQKYcat2sX https://cassyni.com/events/SdAbmL62otR9CQKYcat2sX/abstract https://cassyni-user-files-prod.s3.amazonaws.com/A1fkj1s6vL8JRwATDaknqc https://cassyni.com/events/SdAbmL62otR9CQKYcat2sX?videoPreview=1 SSP Innovation Showcase (Winter 2023)nohttps://cassyni.com/events/SdAbmL62otR9CQKYcat2sX?videoPreview=12023-02-01T06:00:00+00:003340.4SSP Society for Scholarly PublishingJoin us for a special, free webinar highlighting new and exciting industry innovations. Speakers will present solutions or technology in seven-minute presentations, providing a unique opportunity to get a glimpse of the latest developments in the industry. • OA Agreement Intelligence • Enhance Your Platform Experience with Freeform Content • Enable Scalable Manuscript Transfers through Transfer Desk Suite • Use AI to power Open Sciencehttps://cassyni-user-files-prod.s3.amazonaws.com/A1fkj1s6vL8JRwATDaknqc https://cassyni.com/events/5swDpcuzNf9t4QsGLTxgz1/seminar/qa https://cassyni.com/slides/outline/5swDpcuzNf9t4QsGLTxgz1 https://cassyni.com/events/5swDpcuzNf9t4QsGLTxgz1/abstract https://cassyni-user-files-prod.s3.amazonaws.com/48EpWLprn6HJzuHZKSd6a2 https://cassyni.com/events/5swDpcuzNf9t4QsGLTxgz1?videoPreview=1 Learning Physically and Cognitively Grounded Robotic Assistantsnohttps://cassyni.com/events/5swDpcuzNf9t4QsGLTxgz1?videoPreview=12026-02-20T20:00:00+00:002681.04School of Data ScienceFor robotic assistants to be useful and helpful in our homes or on the road, they must do more than execute motor commands. They must autonomously plan and reason about tasks, recognize human needs, and offer proactive assistance across diverse scenarios. While these physical and social interactions seem to be effortless for humans, they remain very difficult for robots. Inspired by how humans understand and interact with the physical and social world, in this talk, I will explore how robots can bridge this gap. First, I will demonstrate how integrating multiple modalities (e.g., vision, tactile sensing, and force control) can enable efficient and robust manipulation of objects. Second, I will show how robots can employ Theory of Mind reasoning to ground human behaviors, enabling diverse and effective social interaction. I will conclude by discussing how these learned abilities can augment human capabilities to create more useful and helpful robotic assistants.https://cassyni-user-files-prod.s3.amazonaws.com/48EpWLprn6HJzuHZKSd6a2 https://cassyni.com/slides/outline/2v5Df9Yj9Gm4rBZDUuhhdP https://cassyni.com/events/2v5Df9Yj9Gm4rBZDUuhhdP/abstract https://cassyni-user-files-prod.s3.amazonaws.com/XwYuw5b4VtiPFfgLLzeM2W https://cassyni.com/events/2v5Df9Yj9Gm4rBZDUuhhdP?videoPreview=1 Editor Talk - Arley Muthnohttps://cassyni.com/events/2v5Df9Yj9Gm4rBZDUuhhdP?videoPreview=12026-03-11T20:00:00+00:00990.24Ecology and Evolution Advice and thoughts on the publication process from Ecology and Evolution editor in chief, Arley Muth.https://cassyni-user-files-prod.s3.amazonaws.com/XwYuw5b4VtiPFfgLLzeM2W https://cassyni.com/slides/outline/CJN5RWKp5cMZtEZjCNM6b7 https://cassyni.com/events/CJN5RWKp5cMZtEZjCNM6b7/abstract https://cassyni-user-files-prod.s3.amazonaws.com/P2ft8LYFWhAZJAPAnar3Av https://cassyni.com/events/CJN5RWKp5cMZtEZjCNM6b7?videoPreview=1 Meta-Radiology • Imaging Exploration Lecture Series • New Technologies and Research Advances in Cardiovascular Radiologynohttps://cassyni.com/events/CJN5RWKp5cMZtEZjCNM6b7?videoPreview=12026-03-03T01:00:00+00:002705.16NoneTo provide a forum for the dissemination of new research findings in the field of radiology, the journal [Meta-Radiology(Metrad)] (https://www.keaipublishing.com/en/journals/meta-radiology/) has Launched “Image Exploration Lecture Series” since 2024. The series regularly invites leading experts and active researchers to share their cutting-edge work. ♾️ Date: Mar. 03, 2026 ♾️ Speaker: Professor Lü Bin Director, Medical Imaging Center Director, Department of RadiologyFuwai Hospital, Chinese Academy of Medical Sciences https://cassyni-user-files-prod.s3.amazonaws.com/P2ft8LYFWhAZJAPAnar3Av https://cassyni.com/slides/outline/Ng1PWVRihauiZDZGW3ERuF https://cassyni.com/events/Ng1PWVRihauiZDZGW3ERuF/abstract https://cassyni-user-files-prod.s3.amazonaws.com/37scDd2hhsCbHqmGNJfqux https://cassyni.com/events/Ng1PWVRihauiZDZGW3ERuF?videoPreview=1 Physiology: The Science Life Depends On (Lightning Talk)nohttps://cassyni.com/events/Ng1PWVRihauiZDZGW3ERuF?videoPreview=12026-02-25T13:00:00+00:00454.92Researcher to ReaderHow publishing, editorial leadership, partnerships and community networks sustain physiology – the science on which life depends. Drawing on his career as a physiologist and prolific author, the speaker will show how society publishing supports discoveries that translate into real-world health impact: from lifelong disease risk to recovery and cure.https://cassyni-user-files-prod.s3.amazonaws.com/37scDd2hhsCbHqmGNJfqux https://cassyni.com/slides/outline/AKoHMQFbj94uLm5gSnZS3P https://cassyni.com/events/AKoHMQFbj94uLm5gSnZS3P/abstract https://cassyni-user-files-prod.s3.amazonaws.com/992ERfYeDMpTsqLqohp2Qn https://cassyni.com/events/AKoHMQFbj94uLm5gSnZS3P?videoPreview=1 What is the Reflect! platform?nohttps://cassyni.com/events/AKoHMQFbj94uLm5gSnZS3P?videoPreview=12021-06-28T06:00:00+00:00582.52 School of Public PolicyA brief overview of the Reflect! platform. The Reflect! Platform facilitated collaboration on wicked problems. Wicked problems are complex problems whose complexity results from the fact that they can be framed in a number of different ways, depending on who is looking at them. Stakeholders frame wicked problems differently depending on their interests, needs, values, worldviews, and background knowledge. Our ability to cope with wicked problems—and with the conflicts they usually create—is crucial for consensus building in the political and corporate world, and for any task that requires collaboration among people with different backgrounds. Reflect! could be used in problem-based learning projects (especially in ethics and social science education), by teams of professionals, and by stakeholders in controversies—both in face-to-face deliberation and online.https://cassyni-user-files-prod.s3.amazonaws.com/992ERfYeDMpTsqLqohp2Qn https://cassyni.com/slides/outline/PAezZB5F93TmYz6A6UXEAZ https://cassyni.com/events/PAezZB5F93TmYz6A6UXEAZ/abstract https://cassyni-user-files-prod.s3.amazonaws.com/EY46x6NJ5eV1KRM8pHQycS https://cassyni.com/events/PAezZB5F93TmYz6A6UXEAZ?videoPreview=1 B1 – Enhancing Research Support with Generative AI: The Proposal Guidelines Extraction Systemnohttps://cassyni.com/events/PAezZB5F93TmYz6A6UXEAZ?videoPreview=12026-04-20T10:15:00+00:002967.92Research Analytics SummitResearch proposal guidelines from agencies such as NSF, NIH, and DOE are often lengthy, complex, and difficult to navigate. To address this challenge, our team developed the Proposal Guidelines Extraction System, a full – stack Generative AI solution that streamlines how researchers interpret funding opportunity documents. The system ingests a PDF, extracts its text while preserving structural hierarchy, and uses a Large Language Model (LLM) to automatically identify key elements such as deadlines, budget limits, etc. These extracted components are displayed in a clean, intuitive interface alongside the original document, enabling users to jump directly to relevant sections and significantly reduce manual review time. Additional features include search and filter functions, configurable data element definitions, and linked navigation between extracted data and source text. This session will provide an end – to – end walkthrough of the system’s design and implementation—from text extraction and LLM prompt engineering to frontend development and database architecture. Participants will gain insight into how LLMs interpret prompts, generate structured outputs, and how this framework can extend to other administrative or document – intelligence workflows across research administration and beyond. Familiarity with programming languages, technical concepts, and Foundational knowledge of LLMs is required. IT professionals, research admins, and curious learners are welcome to attend.https://cassyni-user-files-prod.s3.amazonaws.com/EY46x6NJ5eV1KRM8pHQycS https://cassyni.com/slides/outline/HjXM3exUK1NhA7qvVZXSB7 https://cassyni.com/events/HjXM3exUK1NhA7qvVZXSB7/abstract https://cassyni-user-files-prod.s3.amazonaws.com/KYxXqiyNkhs8wJinJNSVK4 https://cassyni.com/events/HjXM3exUK1NhA7qvVZXSB7?videoPreview=1 E4 – Evaluation of Research Impact for Early Career Research Professionalsnohttps://cassyni.com/events/HjXM3exUK1NhA7qvVZXSB7?videoPreview=12026-04-20T14:45:00+00:001586.68Research Analytics SummitHow do we evaluate research responsibly—especially when traditional metrics reward only a narrow slice of what researchers actually contribute? And how do we ensure early‑career researchers aren’t disadvantaged by evaluation systems that privilege citations and publication volume over collaboration, engagement, interdisciplinarity, or societal impact? This talk presents a technical, data‑driven approach to building and implementing responsible research evaluation frameworks at the institutional level. You will see the feasibility and value of adopting cross‑disciplinary, capacity‑focused evaluation frameworks that elevate early‑stage impact signals rather than long‑lag citation metrics. If your team or institution is wrestling with how to evaluate researchers better, this session will offer a replicable model, practical tools, and clear principles for doing so. https://cassyni-user-files-prod.s3.amazonaws.com/KYxXqiyNkhs8wJinJNSVK4 https://cassyni.com/slides/outline/W5jTCk8bHTDZ3o5jTv6AKF https://cassyni.com/events/W5jTCk8bHTDZ3o5jTv6AKF/abstract https://cassyni-user-files-prod.s3.amazonaws.com/4wRzdXGoQo9uvCbeuAtgpv https://cassyni.com/events/W5jTCk8bHTDZ3o5jTv6AKF?videoPreview=1 G1 - Collaborative innovation: Building AI-native research intelligence for strategic impactnohttps://cassyni.com/events/W5jTCk8bHTDZ3o5jTv6AKF?videoPreview=12026-04-21T10:15:00+00:002291.0Research Analytics SummitWeb of Science Research Intelligence is an AI-native platform developed in partnership with the research community to help institutions increase funding, optimize strategy, and demonstrate impact. By integrating trusted data from publications, patents, grants, policy documents, and clinical trials, the solution provides a holistic, evidence-based view of research performance. Its transparent societal impact framework and responsible AI make advanced analytics accessible—surfacing emerging topics, funding opportunities, expert networks, and actionable recommendations aligned with institutional priorities. This session will highlight how collaborative design shaped the platform and showcase practical use cases for research strategy and impact assessment.https://cassyni-user-files-prod.s3.amazonaws.com/4wRzdXGoQo9uvCbeuAtgpv https://cassyni.com/slides/outline/3QiphqCFajK7qx675LzVth https://cassyni.com/events/3QiphqCFajK7qx675LzVth/abstract https://cassyni-user-files-prod.s3.amazonaws.com/WRW4NP5b5roj8pK9koRQuU https://cassyni.com/events/3QiphqCFajK7qx675LzVth?videoPreview=1 AI for Nanoscience: From Literature Mining to Intelligent Discoverynohttps://cassyni.com/events/3QiphqCFajK7qx675LzVth?videoPreview=12026-05-20T12:20:00+00:002362.36Connecting Science, Publishing, and InnovationThe scientific publishing landscape is undergoing a fundamental transformation as artificial intelligence reshapes how researchers engage with the literature. This talk explores the convergence of AI and scholarly publishing, with a focus on applications in nanoscience and the broader physical sciences. We present how Wiley is deploying AI-powered tools to move beyond traditional keyword search toward intelligent, context-aware discovery. Central to this vision is the Scholar Gateway, a retrieval-augmented platform that enables researchers to query curated collections of peer-reviewed content using natural language, receiving precise, citation-backed answers grounded in the published literature rather than generic model outputs. Through live demonstrations, we illustrate how these technologies transform the way researchers engage with published knowledge, reducing time from question to insight while maintaining the rigour and traceability that scientific inquiry demands. Finally, we outline the publishing industry's broader vision: a future where AI serves not as a replacement for peer review and editorial curation, but as an amplifier - transforming publishers from gatekeepers of static documents into providers of living, queryable knowledge infrastructure that accelerates scientific discovery.https://cassyni-user-files-prod.s3.amazonaws.com/WRW4NP5b5roj8pK9koRQuU https://cassyni.com/events/DnLWgBnGoLwYNTPF6SwPaD/seminar/qa https://cassyni.com/slides/outline/DnLWgBnGoLwYNTPF6SwPaD https://cassyni.com/events/DnLWgBnGoLwYNTPF6SwPaD/abstract https://cassyni-user-files-prod.s3.amazonaws.com/3EvM6ZRKkzFH4FvyXVShvN https://cassyni.com/events/DnLWgBnGoLwYNTPF6SwPaD?videoPreview=1 Informing the management of riverine and floodplain vegetationnohttps://cassyni.com/events/DnLWgBnGoLwYNTPF6SwPaD?videoPreview=12026-03-27T01:15:00+00:002243.6Institute for Applied EcologyAs the ecological consequences of water resource development have become more widely recognised, so too has our understanding of the needs of riverine ecosystems. This growing awareness has driven significant investment in environmental water allocations and other complimentary conservation management actions alongside an increasing reliance on science to support, monitor, and evaluate these efforts. Will explore how riverine and floodplain plant conservation and management in the Murray-Darling Basin has become increasingly ambitious. This complexity demands multidisciplinary knowledge and adaptive strategies to navigate trade-offs, evaluate outcomes and prioritise outcomes. Will illustrate the tools and technologies we are using alongside Indigenous knowledge systems to support decision-making and evaluation. I Will draw on examples ranging from the use of drone imagery, the application of population genetics, the use of long-term data sets and Indigenous knowledge and ways of knowing.https://cassyni-user-files-prod.s3.amazonaws.com/3EvM6ZRKkzFH4FvyXVShvN https://cassyni.com/events/8qt6Kypup8Ky4WnxsvpTo3/abstract https://cassyni-user-files-prod.s3.amazonaws.com/P8ztW9RjcZpqSGRp63CgsQ https://cassyni.com/events/8qt6Kypup8Ky4WnxsvpTo3?videoPreview=1 Kidney Talks - Beyond hypertension and diabetes: what to look out for?nohttps://cassyni.com/events/8qt6Kypup8Ky4WnxsvpTo3?videoPreview=12026-09-16T12:00:00+00:002213.36Education for Primary Care Health Care ProfessionalsAbstract not yet added.https://cassyni-user-files-prod.s3.amazonaws.com/P8ztW9RjcZpqSGRp63CgsQ https://cassyni.com/slides/outline/PfLDiVEeyrwbNT5ftaeCLm https://cassyni.com/events/PfLDiVEeyrwbNT5ftaeCLm/abstract https://cassyni-user-files-prod.s3.amazonaws.com/PtPiCVGy4rW1XYbNoMKFCS https://cassyni.com/events/PfLDiVEeyrwbNT5ftaeCLm?videoPreview=1 Powering Progress: How Policy Stacking Impacts Energy Securitynohttps://cassyni.com/events/PfLDiVEeyrwbNT5ftaeCLm?videoPreview=12026-03-18T09:00:00+00:003770.0 School of Public PolicyThis talk was part of the U.S. National Academy of Engineering enPower webinar series. This presentation to the National Academy of Engineering addresses the rapid U.S. energy policy and technology transition, investigating its impacts on the economy and energy security through a holistic systems approach. The GT-NEMS 2023 model, a computable general equilibrium tool, was employed to simulate the stacking of several economic trends and energy policies, with outcomes assessed across four dimensions of energy security: availability, accessibility, acceptability (including GDP and carbon emissions), and affordability. Major economic trends modeled included the growth of electricity demand for data centers, estimated to increase from 155 TWh to 733 TWh by 2035, and the uptake of electric light-duty vehicles. Modeled energy policies comprised high oil and gas supply (HO&GS), small modular reactor (SMR) subsidies (increasing the existing 4.8% learning rate by 20%), AI-enabled demand-side management (DSM) allowing peak reduction/load shifting up to 50% by 2035, and renewable energy (RE) subsidies. Analysis indicates that data center growth could reduce U.S. GDP by approximately 0.2% over a decade due to electricity demand. Electric vehicle adoption benefits higher-income households through energy savings and lower-income households through reduced gasoline prices by roughly 10 cents per gallon. HO&GS policies significantly decrease oil imports and boost liquefied natural gas exports. SMR growth is notably enhanced when coupled with AI-driven DSM, particularly from 2040-2050, as DSM facilitates the integration of stationary baseload generation. While HO&GS, SMR, and DSM policies contribute to GDP growth, they also increase carbon emissions if not accompanied by RE. A comprehensive policy approach combining high oil and gas supply, strong vehicle electrification standards, and renewable energy subsidies, coupled with demand response and SMR development, delivers benefits across all dimensions of energy security, notably reducing carbon emissions and improving affordability.https://cassyni-user-files-prod.s3.amazonaws.com/PtPiCVGy4rW1XYbNoMKFCS https://cassyni.com/events/RdvduDpkjhAMUAMuFYW8mK/abstract https://cassyni-user-files-prod.s3.amazonaws.com/TzvCjREmSo2nSYYpyeaKnn https://cassyni.com/events/BK87ZQ4Y1R6n9zc5qKyCUu/abstract https://cassyni-user-files-prod.s3.amazonaws.com/PVpCrTHM6GUHDMyMpsb1ft https://cassyni.com/slides/outline/MgmRePASdPevqHBU6qTs2D https://cassyni.com/events/MgmRePASdPevqHBU6qTs2D/abstract https://cassyni-user-files-prod.s3.amazonaws.com/PbNqnrq8TgVLzGE7G6QJE2 https://cassyni.com/events/MgmRePASdPevqHBU6qTs2D?videoPreview=1 Labor complexity and the future of worknohttps://cassyni.com/events/MgmRePASdPevqHBU6qTs2D?videoPreview=12026-05-04T08:00:00+00:004036.68School of Data ScienceArtificial Intelligence has evolved and now challenges our understanding of skills, careers, and the future of work. Using a variety of data on employment, occupations’ skill requirements, millions of workers’ resumes, this talk will explore how workers’ skills shape their careers and how automation estimates fit into a framework for career adaptability and the economic resilience of labor markets. https://cassyni-user-files-prod.s3.amazonaws.com/PbNqnrq8TgVLzGE7G6QJE2 https://cassyni.com/events/JEECKbdmZBnHoasuTB5uVP/abstract https://cassyni-user-files-prod.s3.amazonaws.com/FRcfF5Jrk8CS7cFKHF4CUW https://cassyni.com/events/5PQ7ETL1YeJgydwbw39GC5/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Tin9eT9YfCtzJ5BxeJfqEE https://cassyni.com/events/7re8TsZdjw5BLaRAUj3tv1/seminar/qa https://cassyni.com/slides/outline/7re8TsZdjw5BLaRAUj3tv1 https://cassyni.com/events/7re8TsZdjw5BLaRAUj3tv1/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Tweg7Di6GkwMogNWNXZkbY https://cassyni.com/events/7re8TsZdjw5BLaRAUj3tv1?videoPreview=1 Advanced Treatment Strategies for Urban Wastewater: Quaternary Treatments for Safe Discharge and Potential Reusenohttps://cassyni.com/events/7re8TsZdjw5BLaRAUj3tv1?videoPreview=12026-07-08T11:00:00+00:003411.32ElsevierUrban wastewater treatment is increasingly expected to go beyond conventional compliance, addressing contaminants of emerging concern, microbial hazards, antimicrobial resistance-related elements, and residual organic matter. This shift has driven the development of quaternary treatment strategies designed not only to reduce the impact of wastewater discharges on receiving waters, but also to support the safe and fit-for-purpose reuse of treated effluents. This webinar will present recent developments achieved within several research projects focused on advanced treatment strategies for urban wastewater. The presentation will illustrate the evolution from laboratory-scale research to pilot-scale implementation, highlighting the development and integration of advanced treatment processes for improved effluent quality. The webinar will also discuss the need to assess treatment performance from a broader perspective than target contaminant removal alone. Particular attention will be given to the different objectives and challenges associated with safe discharge and water reuse, including the preservation of reclaimed-water quality beyond the treatment stage.https://cassyni-user-files-prod.s3.amazonaws.com/Tweg7Di6GkwMogNWNXZkbY https://cassyni.com/events/9qEYec9jVmHwSHhPqguqLZ/abstract https://cassyni-user-files-prod.s3.amazonaws.com/BXuGHHyWSGUzwSd8LwfTmG https://cassyni.com/slides/outline/Fm3RKSRvAcrqecw9Ei2bWD https://cassyni.com/events/Fm3RKSRvAcrqecw9Ei2bWD/abstract https://cassyni-user-files-prod.s3.amazonaws.com/VkHPPtXrmJQX7C82aeH5ka https://cassyni.com/events/Fm3RKSRvAcrqecw9Ei2bWD?videoPreview=1 Climate Change Threatens Micronutrient Density of staple cropsnohttps://cassyni.com/events/Fm3RKSRvAcrqecw9Ei2bWD?videoPreview=12026-08-07T13:00:00+00:003889.12Advanced ScienceMicronutrients are vital for human health. Wheat is a major staple crop and a significant source of minerals and B-vitamins. The impact of multifactorial climate change on their content remains largely unknown, introducing uncertainty to human nutrition and well-being. Here, we used an Ecotron to evaluate micronutrient levels in European winter wheat (Triticum aestivum var. Asory) under historical and projected climate conditions, incorporating gradients of atmospheric CO2, temperature, precipitation, and light intensity representative of ongoing climate change in Western Europe. Our findings indicate that future climates will strongly diminish multiple minerals and B-vitamins in grains, thereby posing a significant challenge for global public health.https://cassyni-user-files-prod.s3.amazonaws.com/VkHPPtXrmJQX7C82aeH5ka https://cassyni.com/events/2vDLEJ8AA5Phasd4sb1F1f/seminar/qa https://cassyni.com/slides/outline/2vDLEJ8AA5Phasd4sb1F1f https://cassyni.com/events/2vDLEJ8AA5Phasd4sb1F1f/abstract https://cassyni-user-files-prod.s3.amazonaws.com/AQgrwj24WfiUazdNz6uFUz https://cassyni.com/events/2vDLEJ8AA5Phasd4sb1F1f?videoPreview=1 Lessons from Henrietta Lacks nohttps://cassyni.com/events/2vDLEJ8AA5Phasd4sb1F1f?videoPreview=12026-08-21T19:30:00+00:002760.6npj Digital Medicine Learn about significant challenges concerning data privacy and governance affecting medical AI. https://cassyni-user-files-prod.s3.amazonaws.com/AQgrwj24WfiUazdNz6uFUz https://cassyni.com/slides/outline/XZjWa46wQYjFgoBVcQEEA9 https://cassyni.com/events/XZjWa46wQYjFgoBVcQEEA9/abstract https://cassyni-user-files-prod.s3.amazonaws.com/SreRbT8qHpNcH6DYvdDnB8 https://cassyni.com/events/vqFo3HT55WH8FBR5hw8kM/seminar/qa https://cassyni.com/slides/outline/vqFo3HT55WH8FBR5hw8kM https://cassyni.com/events/vqFo3HT55WH8FBR5hw8kM/abstract https://cassyni-user-files-prod.s3.amazonaws.com/V8UP62yTDUiMLjjv2cuhHp https://cassyni.com/events/vqFo3HT55WH8FBR5hw8kM?videoPreview=1 Publishing with Impact: Insights from Wiley Advanced Editors - Part 3nohttps://cassyni.com/events/vqFo3HT55WH8FBR5hw8kM?videoPreview=12026-06-24T12:00:00+00:004182.52Advanced ScienceThis seminar series segment provided comprehensive insights into effective science communication, open access policies, and open data practices, aiming to enhance the impact of academic publishing. Key communication strategies included tailoring messages to diverse audiences and employing storytelling techniques (change, cause-effect, flaws, empathy). Practical advice for various formats, such as posters, presentations, press releases, and social media, emphasised simplicity, visual clarity, and responsible content sharing. The discussion then shifted to open science, highlighting its global acceleration driven by funder mandates and the need for increased research visibility. Different open access models (green, bronze, gold, diamond) and Creative Commons licenses (CC-BY, CC-BY-NC, CC-BY-NC-ND) were explored, with data indicating that open access articles achieve substantially more views, citations, and Altmetric attention scores. Further emphasis was placed on open data, defined by the FAIR (Findable, Accessible, Interoperable, Reusable) and CARE principles. The critical role of open data in addressing the reproducibility crisis and fueling AI-driven discoveries was underscored, citing global mandates and publisher policies. Practical guidance included crafting clear Data Availability Statements, selecting appropriate repositories, responsibly managing sensitive data, and adhering to specific reporting guidelines for omics data, microscopy, western blots, cell lines, and AI/LLM methods. These integrated approaches are crucial for fostering research credibility, transparency, and broad societal impact.https://cassyni-user-files-prod.s3.amazonaws.com/V8UP62yTDUiMLjjv2cuhHp https://cassyni.com/events/9LZKVHzKewp7cpht3ansAM/seminar/qa https://cassyni.com/slides/outline/9LZKVHzKewp7cpht3ansAM https://cassyni.com/events/9LZKVHzKewp7cpht3ansAM/abstract https://cassyni-user-files-prod.s3.amazonaws.com/CkdRHQXokagMvSTV7HSZx2 https://cassyni.com/events/9LZKVHzKewp7cpht3ansAM?videoPreview=1 Natural fibre micro wind turbine blades for urban environmentnohttps://cassyni.com/events/9LZKVHzKewp7cpht3ansAM?videoPreview=12026-06-17T10:35:00+00:001027.28NoneThe growing demand for sustainable energy technologies has intensified the need for environmentally friendly materials in wind turbine blade manufacturing. Conventional blades are predominantly fabricated from glass and carbon fibre-reinforced composites, which offer excellent mechanical performance but present significant challenges related to energy-intensive production, recyclability, and end-of-life disposal. Natural fibres such as flax, hemp, jute, kenaf, and bamboo have emerged as promising alternatives due to their low density, renewability, biodegradability, and reduced carbon footprint. This study investigates the design and development of wind turbine blade demonstrator made of natural fibre-reinforced polymer composites and recycled polymer foam core for a 1kW micro wind turbine. Numerical and experimental approaches are discussed to assess the structural performance of natural fibre composite blades under aerodynamic and operational loading conditions. The findings indicate that although challenges remain regarding durability and long-term reliability, advances in material engineering and composite processing are enhancing the viability of natural fibre composites in wind and other structural applications.https://cassyni-user-files-prod.s3.amazonaws.com/CkdRHQXokagMvSTV7HSZx2 https://cassyni.com/events/JiuRUuoBQ1G7d3sRFHCsfb/seminar/qa https://cassyni.com/slides/outline/JiuRUuoBQ1G7d3sRFHCsfb https://cassyni.com/events/JiuRUuoBQ1G7d3sRFHCsfb/abstract https://cassyni-user-files-prod.s3.amazonaws.com/BmLDC3Eksfa7uF73B7Bnaa https://cassyni.com/events/JiuRUuoBQ1G7d3sRFHCsfb?videoPreview=1 Understanding the Design of Bamboo Fibre Microstructurenohttps://cassyni.com/events/JiuRUuoBQ1G7d3sRFHCsfb?videoPreview=12026-06-17T15:10:00+00:00926.08NoneHierarchical microstructural analysis of plant-extracted technical fibres such as bamboo is critical for advancing sustainable composite development, particularly with respect to geometric modelling, property prediction, and manufacturing optimization. Precise segmentation of anatomical phases elementary fibres, middle lamella, and lumen is essential for quantifying the morphological gradients and structural heterogeneity that govern interfacial stress transfer and mechanical performance. This work presents an integrated experimental and computational framework developed to decode the design principles of the bamboo fibre. A Deep Learning–based segmentation model was coupled with automated morphometric analysis. Critically, this approach resolves the sub-micron middle lamella, unresolvable by conventional µCT imaging, and provides the area fractions of middle lamella, cell wall, and lumen required as inputs for micromechanical stress-transfer and stiffness prediction models. The framework reveals systematic morphological gradients across the fibre cross-section, consistent with a functionally graded architecture optimized by nature for bending loading. These geometric findings were complemented by 3D reconstruction at the microscale via micro photogrammetry and by Digital Image Correlation experiments on single fibres. The transverse strain Exx transitioned monotonically across the fibre width. Failure was dominated by asymmetric defibrillation and cell-wall cracking, with an average tensile strength of 634 MPa measured. Together, these results identify cross-sectional geometric gradients and intermittent load-sharing among elementary-fibre clusters as the key design parameters governing damage evolution, providing a quantitative basis for bio-inspired composite design. https://cassyni-user-files-prod.s3.amazonaws.com/BmLDC3Eksfa7uF73B7Bnaa https://cassyni.com/slides/outline/VbAiVx2j45Sb9KhSrpSZcR https://cassyni.com/events/VbAiVx2j45Sb9KhSrpSZcR/abstract https://cassyni-user-files-prod.s3.amazonaws.com/4MMbn2P9UpPbn7KmQxvUb8 https://cassyni.com/events/VbAiVx2j45Sb9KhSrpSZcR?videoPreview=1 Heat stress or high VPD? Towards disentangling thermal effects and atmospheric drought effects on vegetation.nohttps://cassyni.com/events/VbAiVx2j45Sb9KhSrpSZcR?videoPreview=12026-06-03T11:45:00+00:001753.52While we often attribute plant responses to heat events and warming to temperature stress, these thermal stresses usually coincide with periods of high vapour pressure deficit (VPD). The co-occurrence of these two stresses makes it difficult to ascertain the relative roles of temperature and high VPD on vegetation, which could lead to misinterpretation of what is driving negative responses of vegetation to heat. Here, I will draw on results from meta-analyses of warming studies and of elevated VPD experiments, as well as ecosystem responses to climate, to discuss the need to account for VPD effects when considering how high temperatures affect plants and ecosystems.https://cassyni-user-files-prod.s3.amazonaws.com/4MMbn2P9UpPbn7KmQxvUb8 https://cassyni.com/events/UbsWQajgBALSUZsSkqyEoX/abstract https://cassyni-user-files-prod.s3.amazonaws.com/EWbyLwgaLNejSy6tBLcPnn https://cassyni.com/slides/outline/PAo78Keg9r6QHgA1V9pmYq https://cassyni.com/events/PAo78Keg9r6QHgA1V9pmYq/abstract https://cassyni-user-files-prod.s3.amazonaws.com/WoU8GoHggwnQS6BLBkcx8e https://cassyni.com/events/W5sZmti2JFrBnV9arbPhhX/abstract https://cassyni-user-files-prod.s3.amazonaws.com/8e4vaUosCqUTPWFStfXSJJ https://cassyni.com/events/3QrwGymgbXwkae9xU2J3Gy/abstract https://cassyni-user-files-prod.s3.amazonaws.com/KWMu243Y5Y36fnCDVZ2SXg https://cassyni.com/events/CoBR9y4ewEU2SPd6P9mc9b/abstract https://cassyni-user-files-prod.s3.amazonaws.com/BE42TbPVQVyfMzyyTbCCEA https://cassyni.com/events/MCgGtHpeF9dN5YEYLpSqss/abstract https://cassyni-user-files-prod.s3.amazonaws.com/YEce9H6cVsLJ3mPqcgUbBC https://cassyni.com/events/LDP4nvXbNEXDQnQYEqyX4y/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Pdm2wvuEqG3tpzEWYCdWEi https://cassyni.com/events/6PE9VnQu5R1jmbwqLAd7L9/abstract https://cassyni-user-files-prod.s3.amazonaws.com/E7zvJ9pii7eQMjDxjRmXmG https://cassyni.com/events/BKiBxct9TzZ3E2EWqFgUjw/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Lt1bLUtHqJnd89mExCmwSn https://cassyni.com/events/Li4HxEh1D413EFQ42x6VFB/abstract https://cassyni-user-files-prod.s3.amazonaws.com/QNZetbWmuVMfzrF6DvsBdp https://cassyni.com/events/2T5MMcJVU6rqr6cPVRPENy/seminar/qa https://cassyni.com/slides/outline/2T5MMcJVU6rqr6cPVRPENy https://cassyni.com/events/2T5MMcJVU6rqr6cPVRPENy/abstract https://cassyni-user-files-prod.s3.amazonaws.com/GPDuBgVXRt8RpFMWQMswiE https://cassyni.com/events/2T5MMcJVU6rqr6cPVRPENy?videoPreview=1 15th international Biometals Webinarsnohttps://cassyni.com/events/2T5MMcJVU6rqr6cPVRPENy?videoPreview=12025-05-06T13:00:00+00:004701.04BioMetalsMany transition metals of the first period of the periodic system of the elements are essential to living cells but also toxic at higher concentrations. How do bacteria manage to allocate the correct metal ion to a protein that requires it? First of all, uptake and efflux reactions have to be considered. Transporters with a broad range of substrates import transition metal cations, magnesium or metal complexes into the cells, with more specific importers supplementing them under starvation conditions. From the imported metal bouquet, inducible efflux system remove those cations that are present in excess. This results in a flow equilibrium that adjusts the cation composition in the cytoplasm and the concentration of the individual cations. We could demonstrate that such a process is indeed occurring in our model bacterium and how synthesis of the responsible transport system is regulated. Secondly, this cytoplasmic metal cation bouquet is interacting with metal-binding components of the cytoplasm. The role of the third pillar of metal homeostasis, alternative sigma factors, has been fully understood yet in this bacterium. The paper on which this talk is based exploits a protein that kinetically traps metals to test predictions of the speciation of metalation inside cells. The protein (MncA) was first discovered in a cyanobacterium where it traps manganese. Back in 2008 MncA helped to reveal how the specificity of metalation can depend on metal availabilities at protein folding. Since 2008, DNA-binding metal sensors have been calibrated so that intracellular metal availabilities can be estimated. Using such estimations a metalation calculator was produced, and an online version will be demonstrated in this talk (https://metalation-calculator.awh.durham.ac.uk/). Notably, the calculators’ metalation predictions had not been directly tested because proteins often exchange metals post-extraction. But this constraint would not apply to a protein that kinetically traps metals. In the new research, pairs of buffered metals were used at folding to determine MncA’s in vitro metal preferences. All binding-preferences follow the Irving Williams series with copper most preferred and the cognate metal manganese least preferred in vitro. However, the metalation calculations predicted, and experiments directly confirmed, that at the intracellular metal availabilities estimated in E. coli (grown in LB medium) MncA is mis-metalated with iron. The paper shows how metalation can be predictably switched in cells supplemented with metals. It also shows how MncA can be used to refine estimated intracellular metal availabilities which in turn uncovered how cobalt alters the availability of intracellular iron. Crucially, these studies show that metalation will not be a fait accompli in Engineering Biology. This suggests opportunities to use such calculations to optimise biomanufacturing by optimising the metalation of enzymes, both native and artificial, inside engineered organisms. https://cassyni-user-files-prod.s3.amazonaws.com/GPDuBgVXRt8RpFMWQMswiE https://cassyni.com/slides/outline/Boy5QVKGGQ8xrKn1LqipSq https://cassyni.com/events/Boy5QVKGGQ8xrKn1LqipSq/abstract https://cassyni-user-files-prod.s3.amazonaws.com/BMVmrC9WpUoLBtBne5Tm4J https://cassyni.com/events/Boy5QVKGGQ8xrKn1LqipSq?videoPreview=1 What’s Their Secret? Tips from Successful Academic Writers in Health Professions Educationnohttps://cassyni.com/events/Boy5QVKGGQ8xrKn1LqipSq?videoPreview=12025-03-26T09:00:00+00:003653.2AAMCFinding time, space, and motivation to write can be a challenge for health professions educators, scholars, and researchers throughout their careers. In this video, Bridget O’Brien, PhD, explores Helen Sword’s “Air & Light & Time & Space” guide to being a more productive and joyful writer. Then Mytien Nguyen, Joshua Jauregui, MD, MHPE, Paula Thompson, PhD, and Bill Ventres, MD, MA share their behavioural, artisanal, social, and emotional writing habits and provide the concrete steps they take to incorporate writing into their busy lives. This webinar is part of the Scholarly Publishing Webinar Series, hosted by Academic Medicine and MedEdPORTAL. For more information on the complete series, see [aamc.org/publishingwebinar](https://www.aamc.org/about-us/mission-areas/medical-education/scholarly-publishing-webinar-series).https://cassyni-user-files-prod.s3.amazonaws.com/BMVmrC9WpUoLBtBne5Tm4J https://cassyni.com/slides/outline/Pfe4yQuQQq8az1KvzfaPWm https://cassyni.com/events/Pfe4yQuQQq8az1KvzfaPWm/abstract https://cassyni-user-files-prod.s3.amazonaws.com/NXwgBKcr14f7HhT72PvUvA https://cassyni.com/events/Pfe4yQuQQq8az1KvzfaPWm?videoPreview=1 Fabrication of cell culture hydrogels by robotic liquid handling automation for high-throughput drug testingnohttps://cassyni.com/events/Pfe4yQuQQq8az1KvzfaPWm?videoPreview=12026-01-07T12:32:43+00:001517.96Communications EngineeringTraditional plastic and glass culture lacks physiological relevance, undermining predictive power in drug discovery. Organoids and organs-on-chip improve biomimicry but do not scale to high-throughput screening (HTS). Even simple hydrogel coatings in HTS plates suffer from curved menisci that disrupt seeding and imaging. We present HYDRA (HYDrogels by Robotic liquid-handling Automation), an automated method to fabricate thin, planar hydrogel films directly in standard plates. Liquid-handlers dispense sub-contact volumes without wall wetting; immediate re-aspiration pins the contact line, leaving a uniform layer with controlled stiffness and thickness. Using fish gelatin hydrogel, HYDRA produces meniscus-free coatings compatible with routine 96- and 384-well workflows and plate-scale quality control. HYDRA was validated through imaging-based dose-response assays with anticancer compounds, engineered epithelial monolayers, and long-term holographic and fluorescence microscopy. It preserved pharmacological sensitivity while supporting high-content imaging on soft, biomimetic substrates, offering a practical bridge between physiological relevance and HTS scalability for early in-vitro drug testing.https://cassyni-user-files-prod.s3.amazonaws.com/NXwgBKcr14f7HhT72PvUvA https://cassyni.com/events/SA2dj83EG2TJUc4KmCqLy/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Ujccm6DwyuwcpDSBvWvwyY https://cassyni.com/slides/outline/3uQ3s9MfRYnwfR5csT7U4u https://cassyni.com/events/3uQ3s9MfRYnwfR5csT7U4u/abstract https://cassyni.com/events/3uQ3s9MfRYnwfR5csT7U4u?videoPreview=1 The Pension Dilemma: Financial Sustainability Versus Intergenerational Equitynohttps://cassyni.com/events/3uQ3s9MfRYnwfR5csT7U4u?videoPreview=12026-06-08T01:00:00+00:001267.36Risk Sciences[Risk sciences](https://www.keaipublishing.com/en/journals/risk-sciences/) aims to foster diverse, multidisciplinary insights in risk sciences, bridging theory and practice through a series of academic activities. This speech record is an excerpt from Zhang's keynote speech for the Risk Sciences Colloquium – [2025 International Workshop on Risk Sharing (IWRS)](https://www.keaipublishing.com/en/journals/risk-sciences/event/2025-international-workshop-on-risk-sharing-iwrs/) , which was held on July 6-7, 2025, in Beijing, China. https://cassyni.com/slides/outline/GkHPBYhCEp7dNrtnbkQVcR https://cassyni.com/events/GkHPBYhCEp7dNrtnbkQVcR/abstract https://cassyni-user-files-prod.s3.amazonaws.com/6KGidaEwPScB4b54bo5G9t https://cassyni.com/events/GkHPBYhCEp7dNrtnbkQVcR?videoPreview=1 From Marcus to Quantum Rate Theory: A Unified Framework for Electron Transfernohttps://cassyni.com/events/GkHPBYhCEp7dNrtnbkQVcR?videoPreview=12026-06-10T12:00:00+00:004262.52Nanobionics Research GroupThis seminar introduces a unified physical framework that fundamentally reassesses charge transport at molecular interfaces. Serving as the first installment in a five-part series on Quantum Electrochemistry, the lecture aims to bridge the historical divide between the chemical tradition and the solid-state physics community. Rather than treating electron transfer as a stochastic, thermally activated jump, this framework models it as coherent propagation through a quantum RC circuit. Key Highlights - Bridging Two Paradigms: The presentation highlights the historical disconnect between chemistry, which measures the electron transfer rate in "wet" solution-based environments, and physics, which measures quantum conductance in "dry" solid-state environments. The Role of Quantum Capacitance: The missing link between these two traditions is identified as quantum capacitance. This measurable quantity encodes the electronic density of states of the junction and connects the chemical rate to quantum conductance without requiring free parameters. - A First-Principles Framework: Quantum Rate (QR) Theory builds directly from the foundational constants of nature, specifically Planck's constant and the von Klitzing constant. It replaces the empirical coupling parameters found in classical theories with transmission probabilities derived directly from geometry. Deriving Classical Models: The mathematical and physical derivations demonstrate that both Marcus theory and the LDK (Levich-Dogonadze-Kuznetsov) model are not standalone physical phenomena, but rather emerge naturally as limiting cases of the broader QR Master Equation within the Boltzmann limit. - Room-Temperature Coherence: A revolutionary insight presented is that the "wet" electrolyte environment actually stabilizes quantum coherence rather than destroying it. Dense ionic screening acts as a physical shock absorber, shielding the electron from long-range perturbations and shifting the energy scale to low radio frequencies (3-300 Hz), thereby maintaining coherent tunneling at 300 K. This foundational lecture sets the stage for the remaining four seminars in the series. Future sessions will transition into direct applications, including the analysis of redox monolayers with zero free parameters, extending the theory to quantum dots and graphene, exploring the mesoscopic paradigm of "isoscopy", and translating this fundamental physics into next-generation quantum biosensors and high-affinity drug discovery assays. https://cassyni-user-files-prod.s3.amazonaws.com/6KGidaEwPScB4b54bo5G9t https://cassyni.com/slides/outline/KDZ2XbShqTpAcpQJqiVfvu https://cassyni.com/events/KDZ2XbShqTpAcpQJqiVfvu/abstract https://cassyni-user-files-prod.s3.amazonaws.com/9GJPDb53RbzRRZvxVuge6r https://cassyni.com/events/KDZ2XbShqTpAcpQJqiVfvu?videoPreview=1 Quantum Rate Theory Applied to Quantum Dots, Graphene and Reduced Graphene Oxidenohttps://cassyni.com/events/KDZ2XbShqTpAcpQJqiVfvu?videoPreview=12026-06-24T12:00:00+00:003409.08Nanobionics Research GroupThis of the Quantum Electrochemistry series expands Quantum Rate (QR) Theory beyond molecular electron transfer to characterize zero- and two-dimensional solid-state nanomaterials in ambient liquid electrolytes. Utilizing Quantum Rate Spectroscopy (QRS), the Density of States (DOS) can be mapped in situ at room temperature, eliminating the historic need for ultra-high vacuum or cryogenic conditions. This technique successfully resolved the discrete energy levels of CdTe quantum dots and the continuous relativistic Dirac cone of single-layer graphene. Furthermore, it resolved the supercapacitance anomaly in reduced graphene oxide (rGO); the ~370% surge in capacitance upon reduction is not driven by increased geometric surface area, but by electrons filling defect-induced quantum states at the fundamental resistance limit. Across all tested systems, the internal transport resistance universally converges to the quantum limits of 12.9 kΩ or 25.8 kΩ, providing an unambiguous, universal signature of coherent transport.https://cassyni-user-files-prod.s3.amazonaws.com/9GJPDb53RbzRRZvxVuge6r https://cassyni.com/events/9rBiY1fsC2neSx3oFhhWd3/abstract https://cassyni-user-files-prod.s3.amazonaws.com/XmWwcnkUQZHs662Jd5ev9L https://cassyni.com/events/w973xxCW3hGjVqqDxFzhB/abstract https://cassyni-user-files-prod.s3.amazonaws.com/3euX3Bip9SErtQmfbuhE3Q https://cassyni.com/events/w973xxCW3hGjVqqDxFzhB?videoPreview=1 Exocapitalism with Marik Poliks & Roberto Alonso Trillonohttps://cassyni.com/events/w973xxCW3hGjVqqDxFzhB?videoPreview=12025-10-03T12:00:00+00:005661.2Hong Kong Baptist UniversityIn the first episode of our new Public Program "Books & Authors," Mohammad Salemy engages with Marek Poliks and Roberto Alonso Trillo the authors of "Exocapitalism: Economies with Absolutely No Limits." After introduction, the conversation focuses on the central copncepts of the book, Fold, Lift and Drag. conceptual processes of Fold, Drag, Lift, and arbitrage. Our new series, "Books & Authors" features conversations with Researchers and Instructors from our network who have recently published a book or a major text. Marek Poliks and Roberto Alonso Trillo will teach an upcoming Seminar at The New Centre titled UNDERSTANDING EXOCAPITALISM, starting February 7, 2026. To learn more, please visit the link below.https://cassyni-user-files-prod.s3.amazonaws.com/3euX3Bip9SErtQmfbuhE3Q https://cassyni.com/slides/outline/EHMDD48KUVY8dB5eCJpiqK https://cassyni.com/events/EHMDD48KUVY8dB5eCJpiqK/abstract https://cassyni.com/events/EHMDD48KUVY8dB5eCJpiqK?videoPreview=1 Bachelor of Fine Arts (Hons) in Acting for Global Screennohttps://cassyni.com/events/EHMDD48KUVY8dB5eCJpiqK?videoPreview=12021-10-29T12:00:00+00:003584.96Hong Kong Baptist UniversityThe Bachelor of Fine Arts (Honours) in Acting for Global Screen at Hong Kong Baptist University’s Academy of Film is a pioneering four-year undergraduate program designed to cultivate versatile actors equipped for international film, television, and stage industries. Rooted in the principle of “living truthfully in imagined circumstances,” the curriculum integrates interdisciplinary academic courses with specialized training in voice, movement, screen acting, directing, and emerging technologies such as motion capture and green screen. The program emphasizes the development of empathy and cultural adaptability, fostering a comprehensive artistic hinterland through studies in philosophy, history, and culture. Admission requires demonstration of essential performance qualities, including the ability to inhabit imagined roles, supported by portfolio submissions and auditions assessed by an international panel. Practical experience is embedded via third-year internships with industry partners and collaborations with renowned professionals, ensuring exposure to real-world production environments. The course also facilitates global engagement through planned exchange programs and workshops with prestigious institutions worldwide. Graduates are prepared not only for acting careers but also for diverse roles across the creative industries, benefiting from transferable skills and professional mentorship. This innovative program addresses the evolving demands of screen acting by combining rigorous artistic training with technological fluency and global perspectives, positioning students to contribute meaningfully to the international entertainment landscape. https://cassyni.com/slides/outline/GkbESUMwfnJcz7ZCjzjMZF https://cassyni.com/events/GkbESUMwfnJcz7ZCjzjMZF/abstract https://cassyni-user-files-prod.s3.amazonaws.com/UScRKgBMrzVG6VsJ3yUnqt https://cassyni.com/events/GkbESUMwfnJcz7ZCjzjMZF?videoPreview=1 Fostering Inclusivity through Innovative GE Pedagogy: In Conversation with Community Partnernohttps://cassyni.com/events/GkbESUMwfnJcz7ZCjzjMZF?videoPreview=12023-02-10T12:00:00+00:003262.32Hong Kong Baptist UniversityIn this sharing session, Ms. Bonnie Chiu (JOUR), the GE Teaching Award winner (Individual) of AY2022/23, will share her journey of integrating innovative elements into one of her GE courses to foster student learning and social inclusivity. Bonnie’s community partner, Mr. Martin Lam, the General Secretary of the Hong Kong Sports Association for the Physically Disabled, will also join her in discussing their collaboration experience. The two speakers will showcase how they translated collaboration into student accomplishments, which eventually brought positive impacts to the community.https://cassyni-user-files-prod.s3.amazonaws.com/UScRKgBMrzVG6VsJ3yUnqt https://cassyni.com/slides/outline/Q9txRHLXDEiZHE3oTWu8Gm https://cassyni.com/events/Q9txRHLXDEiZHE3oTWu8Gm/abstract https://cassyni-user-files-prod.s3.amazonaws.com/QFX7mzBtXYBCkXTj7V4JbG https://cassyni.com/events/Q9txRHLXDEiZHE3oTWu8Gm?videoPreview=1 Introductory Remarksnohttps://cassyni.com/events/Q9txRHLXDEiZHE3oTWu8Gm?videoPreview=12023-05-26T12:00:00+00:00702.0Hong Kong Baptist UniversityNo abstracthttps://cassyni-user-files-prod.s3.amazonaws.com/QFX7mzBtXYBCkXTj7V4JbG https://cassyni.com/slides/outline/9LsAkDf55v17E5NJBq7j7B https://cassyni.com/events/9LsAkDf55v17E5NJBq7j7B/abstract https://cassyni-user-files-prod.s3.amazonaws.com/2b1eaowFeaaTbi8QPM5odY https://cassyni.com/events/9LsAkDf55v17E5NJBq7j7B?videoPreview=1 The Zhou xun and its Place in Early Chinese Historiography and Philosophynohttps://cassyni.com/events/9LsAkDf55v17E5NJBq7j7B?videoPreview=12022-04-08T12:00:00+00:005545.04Hong Kong Baptist UniversityThe Zhou xun, an early Chinese text preserved on 211 bamboo slips from the Western Han period, offers a distinctive perspective on historiography and political philosophy during the late Warring States era. This study critically examines the text’s structure, content, and historical context, emphasizing its thematic focus on the consolidation and transfer of power within ruling lineages. Through detailed analysis of missing slips, textual formulas, and narrative organization, the Zhou xun is shown to employ a symmetrical topical arrangement, integrating chronology and geography subordinately. Central to its philosophy is the rejection of primogeniture in favor of meritocratic succession, privileging “worthiness” (xian) as the principal criterion for political legitimacy, thereby advancing a “survival of the worthy” doctrine that explains the endurance of hereditary dynasties. The text’s protagonists, Lord Zhaowen of Zhou and Crown Prince Gong, are positioned to embody ideals of authority and instruction, though their historical relationship remains ambiguous and likely symbolic rather than factual. Comparative analysis reveals that the Zhou xun predates and influenced the Lüshi chunqiu and shares intertextual affinities with the Zuo zhuan, particularly in its use of Shijing citations and critical stance on practices such as human sacrifice. Despite its classification in the Daoist section of the Hanshu, the Zhou xun lacks explicit Daoist cosmology or terminology, calling into question its traditional attribution to Huang-Lao Daoism. The text’s eclectic and sometimes contradictory content reflects complex political and philosophical currents, suggesting it may have originated within the Qin state as a manual for power consolidation rather than as a purely Daoist scripture.https://cassyni-user-files-prod.s3.amazonaws.com/2b1eaowFeaaTbi8QPM5odY https://cassyni.com/events/UbjPqSAFAMhojsobNAfhRF/abstract https://cassyni-user-files-prod.s3.amazonaws.com/9h7ytBzx3uwXwtL9UqwN4n https://cassyni.com/events/UbjPqSAFAMhojsobNAfhRF?videoPreview=1 New Arguments Against Universalismnohttps://cassyni.com/events/UbjPqSAFAMhojsobNAfhRF?videoPreview=12025-03-23T12:00:00+00:005381.72Hong Kong Baptist UniversityAbstract not yet added.https://cassyni-user-files-prod.s3.amazonaws.com/9h7ytBzx3uwXwtL9UqwN4n https://cassyni.com/slides/outline/Bp7BydthHCmbb1qrjX2Mq7 https://cassyni.com/events/Bp7BydthHCmbb1qrjX2Mq7/abstract https://cassyni-user-files-prod.s3.amazonaws.com/5PSo89VSCxK7raanmCBs1Q https://cassyni.com/events/Bp7BydthHCmbb1qrjX2Mq7?videoPreview=1 Chinese knowledge workers’ emotional experiences with social technology platformsnohttps://cassyni.com/events/Bp7BydthHCmbb1qrjX2Mq7?videoPreview=12022-09-27T12:00:00+00:003606.4Hong Kong Baptist UniversityThis study investigates the emotional experiences of Chinese knowledge workers when using social technology platforms, responding to their increasing integration into daily work and the need for a nuanced socio-technical perspective. Utilizing 51 semi-structured in-depth interviews with knowledge workers from super cities, first- and second-tier cities in Mainland China, and Hong Kong, a grounded theory approach was employed for data analysis. Findings reveal three primary categories of workplace emotions. First, **emotions toward work** were shaped by platform interface and performance, such as irritating notification sounds and screen size limitations, which elicited stress and annoyance. Digital metrics, providing weekly summaries of activities like messages and calls, often resulted in an "unhappy achievers" phenomenon, where quantified progress lacked personal meaning. Poor platform design also fostered spillover effects, leading employees to attribute indifferent attitudes to their organizations. Second, **emotional labor** was intensified by social technology features, fostering a "performance culture" (biao yan wen hua) that compelled positive online emotional displays, akin to "surface acting." This was reinforced by a "maintaining stability" (wei wen) mindset, involving self-censorship and the moderation of anonymous feedback channels to suppress negative content. Third, **emotions with work** arose from mediated communication patterns, manifesting as incivility (e.g., non-replying to messages, unclear voice messages, inappropriate channel use for negative feedback) and the strategic deployment of "cuteness" (e.g., creative stickers, playful language, "cuteness is power"). While "cuteness" could facilitate task completion and foster playful sociality, it was also found to blur professional boundaries and obscure underlying labor relations. The study concludes that social technologies are fundamental to contemporary work, acting as agents that shape meaning-making, foster new forms of emotional labor, and enable surveillance, reflecting emerging organizational norms and values in the Chinese context.https://cassyni-user-files-prod.s3.amazonaws.com/5PSo89VSCxK7raanmCBs1Q https://cassyni.com/slides/outline/JimJumDkPCdUtMoZrbuLHK https://cassyni.com/events/JimJumDkPCdUtMoZrbuLHK/abstract https://cassyni-user-files-prod.s3.amazonaws.com/FwT4xSqSeZj3Qga3MvVtht https://cassyni.com/events/JimJumDkPCdUtMoZrbuLHK?videoPreview=1 Sub-setting Data in R - Ep.43nohttps://cassyni.com/events/JimJumDkPCdUtMoZrbuLHK?videoPreview=12022-07-06T12:00:00+00:00239.12Hong Kong Baptist UniversityThis abstract outlines fundamental data manipulation techniques in R, focusing on methods for extracting and combining data subsets. The utility of these techniques is demonstrated through a hypothetical experimental scenario involving subjects divided into three training groups (A, B, and C) who completed a common test, with their scores recorded. The initial step involves importing the complete dataset into R using the `read.csv` function. To isolate data pertaining to a specific training group, such as Training A, the `subset` function is employed with a conditional expression (e.g., `Training == "A"`). The process for combining multiple previously generated subsets, for instance, data from Training A and Training B, is illustrated using the `rbind` function. An alternative approach to achieve a combined subset (e.g., including Training A and B) is also presented, demonstrating how to exclude a specific group (e.g., `Training != "C"`), which yields the same result. The analysis further clarifies the importance of distinguishing between character values (which require quotation marks in R expressions) and numeric values (which do not). These methods are essential for targeted data analysis, enabling researchers to efficiently manage and investigate specific segments of larger datasets.https://cassyni-user-files-prod.s3.amazonaws.com/FwT4xSqSeZj3Qga3MvVtht https://cassyni.com/slides/outline/KDQuxSsGpfBXt8LTT3C8Yd https://cassyni.com/events/KDQuxSsGpfBXt8LTT3C8Yd/abstract https://cassyni-user-files-prod.s3.amazonaws.com/992oWiR2N2Sa5vLVyBiyYr https://cassyni.com/events/KDQuxSsGpfBXt8LTT3C8Yd?videoPreview=1 The Kalam Cosmological Argument w/ Dr Andrew Lokenohttps://cassyni.com/events/KDQuxSsGpfBXt8LTT3C8Yd?videoPreview=12024-04-15T12:00:00+00:004304.64Hong Kong Baptist UniversityJoin us in this enlightening interview with scholar Dr. Andrew Loke as we explore the depths of the Kalam Cosmological Argument and its foundational concepts like the Causal Principle and the debates over infinite regress. Dr. Loke discusses the distinctions between A-Theory and B-Theory of time and their implications on arguments for the existence of the universe. We also delve into the relationship between God and time, as well as the cutting-edge frontiers of quantum mechanics and their philosophical ramifications. This discussion is essential for anyone interested in the intersections of philosophy, theology, and science.https://cassyni-user-files-prod.s3.amazonaws.com/992oWiR2N2Sa5vLVyBiyYr https://cassyni.com/slides/outline/Vb2bvoTJ3GoxQddbU992E9 https://cassyni.com/events/Vb2bvoTJ3GoxQddbU992E9/abstract https://cassyni-user-files-prod.s3.amazonaws.com/28s1hEraGUbsTi4tQ4hibQ https://cassyni.com/events/Vb2bvoTJ3GoxQddbU992E9?videoPreview=1 T06 Test and Scorenohttps://cassyni.com/events/Vb2bvoTJ3GoxQddbU992E9?videoPreview=12023-08-07T12:00:00+00:00484.48Hong Kong Baptist UniversityThis study addresses the challenge of identifying appropriate artificial neural network (ANN) topologies and parameters for predictive modeling. A comparative analysis of different data mining techniques was conducted using Orange data mining software. The methodology involved processing the "Titanic cleaned" dataset, focusing on 'Sex', 'Age', and 'Pclass' features. Models evaluated included a Decision Tree and three Artificial Neural Networks configured with varying hidden layer structures: one with 50 neurons, one with 256 neurons, and another with two hidden layers, each containing 256 neurons. Performance was assessed using the Test & Score widget under different sampling strategies. Initial evaluations using random sampling (10 repetitions, 70% split, stratified) indicated that the ANN with a single 256-neuron hidden layer achieved the highest precision. Subsequent application of a cross-validation sampling technique (5 folds, stratified) initially showed the Decision Tree outperforming ANNs, suggesting data limitations for the neural networks. However, after retraining with this cross-validation approach, the largest ANN (256,256 neurons) demonstrated superior precision over the other networks and the Decision Tree. Further analysis with a confusion matrix revealed that this largest ANN made fewer total errors (141) compared to the 256-neuron ANN (149), although their misclassification distributions differed. These findings highlight the significant influence of sampling techniques and model complexity on predictive performance and the importance of detailed error analysis.https://cassyni-user-files-prod.s3.amazonaws.com/28s1hEraGUbsTi4tQ4hibQ https://cassyni.com/slides/outline/S8VNc1vcy4wKNwL2pUm4hK https://cassyni.com/events/S8VNc1vcy4wKNwL2pUm4hK/abstract https://cassyni-user-files-prod.s3.amazonaws.com/XNuYiZyBthWdCQFpQvdZYA https://cassyni.com/events/S8VNc1vcy4wKNwL2pUm4hK?videoPreview=1 Panel 7: Migration, Exile, Defectionnohttps://cassyni.com/events/S8VNc1vcy4wKNwL2pUm4hK?videoPreview=12021-11-12T12:00:00+00:005427.52Hong Kong Baptist UniversityThis panel examines the complex legacies of migration, exile, and defection during the Cold War in Asia through cultural, historical, and cinematic lenses. The first study analyzes Sinophone displacement by focusing on two types of militarized settlements: the “new villages” in Malaya and the military dependents’ villages (juancun) in Taiwan. Drawing on memoirs, literature, poetry, and film, it reveals how these forced resettlements disrupted established human-environment interactions and cultural ecologies. The new village texts challenge British colonial narratives that framed rural Chinese as primitive squatters by recuperating a lost Nanyang ecological heritage tied to cultivation and settlement. Juancun literature and film articulate the estrangement of mainland Chinese refugees from Taiwanese land and lineage, highlighting tensions between heritage preservation and state-driven urban development. The second presentation explores the portrayal of mainland Chinese migrant women in Taiwan, particularly as “dalumei” (mainland little sisters), within the intersecting frameworks of anti-communism, anti-prostitution policies, and cross-strait intimacy. Ethnographic fieldwork in Taipei’s erotic teahouses uncovers how these women are simultaneously stigmatized as sexual and national threats and subjected to state surveillance, reflecting enduring Cold War mentalities embedded in gendered migration narratives. The final paper investigates the 1959 British film *Ferry to Hong Kong*, situating it as an artifact of imperial nostalgia and Cold War anxieties. The film’s depiction of a stateless exile aboard a ferry between Hong Kong and Macau symbolizes colonial precarity amid geopolitical tensions, while its production history and reception reveal British ambivalence toward postwar imperial decline and anti-communist ideology. Collectively, these studies illuminate how Cold War displacements and cultural productions continue to shape identities, ecologies, and political imaginaries in contemporary East and Southeast Asia.https://cassyni-user-files-prod.s3.amazonaws.com/XNuYiZyBthWdCQFpQvdZYA https://cassyni.com/slides/outline/5PFzfJkaXqg4EwskYMqioo https://cassyni.com/events/5PFzfJkaXqg4EwskYMqioo/abstract https://cassyni-user-files-prod.s3.amazonaws.com/3jMXacNXqH2A1x9ZG4XJm4 https://cassyni.com/events/5PFzfJkaXqg4EwskYMqioo?videoPreview=1 Understanding Wikipedia's Dark Matternohttps://cassyni.com/events/5PFzfJkaXqg4EwskYMqioo?videoPreview=12022-09-16T12:00:00+00:005543.08Hong Kong Baptist UniversityThis study investigates "Wikipedia's dark matter," a term referring to the extensive, often undeclared translated content within its multilingual editions. The research aims to develop methodologies for detecting and understanding this material, exploring its role in knowledge production and adherence to Wikipedia's stated neutral point of view. Case studies, including the assassination of Boris Nemtsov and the Skripal poisoning incident, involved analyzing parallel articles across multiple languages, such as English, Russian, and Chinese. The approach involved examining editing histories, talk pages, and employing digital tools like WikiBlame for tracking text provenance, Langviews for usage statistics, and Manypedia for parallel text viewing. A novel alignment tool is also under development to identify sentence-level translation equivalences. Findings indicate that Wikipedia articles are often complex "patchworks" or "collages" of translated and original content. Significant discrepancies in wording, structural emphasis, and the selection of sources were observed across language versions, directly shaping the articles' points of view. For instance, a speech by Theresa May on the Skripal poisoning showed a crucial wording difference between English and Russian versions, which was traced to differing source material rather than direct editorial manipulation. Formal declarations indicate over 40,000 articles containing content translated from English into Russian, and over 16,000 into Chinese. This highlights translation as a dynamic, often indirect process where source and target texts are "moving objects." The research expands understanding of collaborative content creation on the web and the complex provenance of digital knowledge.https://cassyni-user-files-prod.s3.amazonaws.com/3jMXacNXqH2A1x9ZG4XJm4 https://cassyni.com/slides/outline/7rW1tizCj8SYbtMK63kMXj https://cassyni.com/events/7rW1tizCj8SYbtMK63kMXj/abstract https://cassyni-user-files-prod.s3.amazonaws.com/3qQ2dvPmUgbsUBRcVAynD4 https://cassyni.com/events/7rW1tizCj8SYbtMK63kMXj?videoPreview=1 Book Launch: The Translation of Violence in Children's Literature — Images from the Western Balkansnohttps://cassyni.com/events/7rW1tizCj8SYbtMK63kMXj?videoPreview=12022-03-28T12:00:00+00:005248.88Hong Kong Baptist UniversityConsidering children's literature as a powerful repository for creating and proliferating cultural and national identities, this monograph is the first academic study of children's literature in translation from the Western Balkans. Marija Todorova looks at a broad range of children's literature, from fiction to creative non-fiction and picture books, across five different countries in the Western Balkans, with each chapter including detailed textual and visual analysis through the predominant lens of violence. These chapters raise questions around who initiates and effectuates the selection of children's literature from the Western Balkans for translation into English, and interrogate the role of different stakeholders, such as translators, publishers and cultural institutions in the representation and construction of these countries in translated children's literature, both in text and visually. The speakers will discuss a regional gap in the treatment of children's literature in translation and topics of violence in children's literature.https://cassyni-user-files-prod.s3.amazonaws.com/3qQ2dvPmUgbsUBRcVAynD4 https://cassyni.com/slides/outline/4PxnZwTXevZuaC3kSPNPzu https://cassyni.com/events/4PxnZwTXevZuaC3kSPNPzu/abstract https://cassyni-user-files-prod.s3.amazonaws.com/8K1zzE9zuC5TzMJkaseKL2 https://cassyni.com/events/4PxnZwTXevZuaC3kSPNPzu?videoPreview=1 Concert #1: Traveling Through Time and Cultures Concert Seriesnohttps://cassyni.com/events/4PxnZwTXevZuaC3kSPNPzu?videoPreview=12021-03-21T12:00:00+00:002322.04Hong Kong Baptist UniversityHong Kong has seen challenging times in recent years and this series is intended to remind Hongkongers of the beauty, talent, and creativity that abound in the city. These online concerts are inspired by and dedicated to Hong Kong, and all the performers are based in Hong Kong. The series is also based in part on The Spirit of the Adventurers Concert Series, which was presented in collaboration with the Hong Kong Museum of History in 2018 celebrating the occasion of the Miles Upon Miles: World Heritage along the Silk Road exhibition. In addition to original footage from that series, the concerts feature the world premiere performances of four new works inspired by Hong Kong and written especially for this series – accompanied by video of stunning Hong Kong scenes. Inspiration for the new music comes from Stanley and the Murray House, iconic Canto pop melodies, Hong Kong writer Xi Xi’s work, and reflections on an ever-changing Hong Kong. The series features music by living composers and the audience will have a chance to hear from the composers in their own words as they introduce their works throughout the programs. This project is supported by a grant from the Hong Kong Baptist University. Many thanks to the composers, performers, and help behind the scenes that have made this possible!https://cassyni-user-files-prod.s3.amazonaws.com/8K1zzE9zuC5TzMJkaseKL2 https://cassyni.com/slides/outline/TdcLYWWRCbW5uANm8Yi8PF https://cassyni.com/events/TdcLYWWRCbW5uANm8Yi8PF/abstract https://cassyni-user-files-prod.s3.amazonaws.com/G1gP8MoGBrQaTp7EnH9mHp https://cassyni.com/events/TdcLYWWRCbW5uANm8Yi8PF?videoPreview=1 Molten Oxide Electrolysis: Metal recovery and primary processing?nohttps://cassyni.com/events/TdcLYWWRCbW5uANm8Yi8PF?videoPreview=12021-12-01T23:15:00+00:003787.88The MacDiarmid Institute for Advanced Materials and NanotechnologyMolten oxide electrolysis has the potential to be a more efficient method to produce metals with near zero CO$_2$ emissions compared to traditional methods. If metals can be produced from industrial by-products, such as slags, then the environmental and sustainability benefits are considerable. Our team uses thermodynamic predictions coupled with high-temperature molten oxide electrochemical experiments to explore the opportunities and limitations of this approach. In this talk, I’ll show how we used these methods to characterise the selective reduction of titanium from steelmaking slag. Due to the complex composition of the industrial material, we studied the reduction of titanium from model pseudo-quinary metal oxide melts. Co-reduction of silicon and titanium was achieved with sufficient ionic transport in the oxide melt such that salt-free electrolytes could be used, avoiding the environmental impact of halides. Model binary oxide systems were sought to simplify the electrolyte for titanium extraction and to reduce the operating temperature to about 1100˚C. We identified alkali metal oxides as candidates based on thermodynamic predictions. Our work on these simpler systems, illustrates the challenges of characterising electrochemical behaviour of transition metal molten oxides at elevated temperatures. In new work, we turn our attention to primary production of critical metals. We focus on Ta and Nd, two technology-critical metals. I’ll discuss the characteristics of high temperature electrolytic melts that allow for the extraction of metals, and the opportunities and challenges of molten oxide electrolysis to obtain selected metals from mixtures of chemically similar elements. https://cassyni-user-files-prod.s3.amazonaws.com/G1gP8MoGBrQaTp7EnH9mHp https://cassyni.com/slides/outline/KEfw6n49wtsEWLw7y8v117 https://cassyni.com/events/KEfw6n49wtsEWLw7y8v117/abstract https://cassyni-user-files-prod.s3.amazonaws.com/KEczuAuDWi5h3DQ8qNJ7t2 https://cassyni.com/events/KEfw6n49wtsEWLw7y8v117?videoPreview=1 Surprising acoustic propagation in foams: from liquid to solidnohttps://cassyni.com/events/KEfw6n49wtsEWLw7y8v117?videoPreview=12021-03-16T14:00:00+00:004133.84MetaMATLiquid and solid foams present surprising acoustic properties. A liquid foam is a complex gas-liquid system with a low liquid fraction (<30%). Its rigidity is due to a liquid skeleton, containing the most important part of the liquid and linked by thin liquid films. The bubble size distribution is strongly polydisperse. Over the past years we investigated, in a large frequency range, how a liquid foam behaves when insonified. We showed that liquid foams act as natural and 3D isotropic acoustic metamaterials. Moreover, this work confirmed that liquid foams have important soundproofing properties. First, I will show you how an acoustic wave propagates and dissipates when it travels through a collection of thin liquid films loaded by the surrounding air and a massive liquid skeleton. More recently, we investigated the case of solid foams elaborated by solidification of liquids foams and where the entire liquid skeleton (even films) has been preserved. In this second part, I will show you that the presence of very thin membranes is far from being a handicap to blocking sound.https://cassyni-user-files-prod.s3.amazonaws.com/KEczuAuDWi5h3DQ8qNJ7t2 https://cassyni.com/slides/outline/VcHd58eBAWVf2rEFzErtgd https://cassyni.com/events/VcHd58eBAWVf2rEFzErtgd/abstract https://cassyni-user-files-prod.s3.amazonaws.com/DRvHGFW99VojMi1G6XmwQr https://cassyni.com/events/VcHd58eBAWVf2rEFzErtgd?videoPreview=1 Reflections on constitutive relations for acoustic metamaterialsnohttps://cassyni.com/events/VcHd58eBAWVf2rEFzErtgd?videoPreview=12020-10-13T14:00:00+00:004731.84MetaMATI shall introduce a particular methodology for deriving effective constitutive relations for metamaterials including (because I was asked to do so) a brief account of how it evolved. It applies to composite materials (and metamaterials in particular) whose microstructure is random and is based on the calculation of ensemble averages. Periodic media are included as a special case, by regarding the exact location of a chosen point in any one cell as being distributed randomly over a cell fixed in space. Within that general framework, all definitions are exact. In practice, except in the case of periodic media, some approximation is required. The approximations developed here are derived systematically from a stochastic variational principle and can at least be regarded as “honest” even though not exact. Some general observations will be supported by examples which illustrate both the utility and the limitations of any formulation involving effective constitutive relations. In particular, except in the “homogenization” or “long-wavelength” limit, boundary layers present near any interface between random media, or between one random medium and one with uniform properties, seriously compromise the use of effective properties. The variational approach can, however, be applied directly to this configuration and has been employed to obtain one of only two solutions for reflection and transmission of acoustic waves at the boundary of a two-component random medium.https://cassyni-user-files-prod.s3.amazonaws.com/DRvHGFW99VojMi1G6XmwQr https://cassyni.com/slides/outline/JFM6tnFDfcqMh7QiabWEZb https://cassyni.com/events/JFM6tnFDfcqMh7QiabWEZb/abstract https://cassyni-user-files-prod.s3.amazonaws.com/XdRdzmUJpjpUwQFv7JuD8i https://cassyni.com/events/JFM6tnFDfcqMh7QiabWEZb?videoPreview=1 Leveraging Creative Design and Additive Manufacturing at The University of Aucklandnohttps://cassyni.com/events/JFM6tnFDfcqMh7QiabWEZb?videoPreview=12021-09-21T04:00:00+00:003007.08The Auckland Bioengineering Institute3D printing (3DP) has become an extremely popular manufacturing tool with the industry currently being estimated at ~NZ$17billion. This success can be attributed to both the technologies versatility in creating complex geometries and fantastic marketing. However, as with many emerging technologies its marketing could be somewhat misleading and has left the technology vulnerable to misuse. While it is possible to create an incredible variety of parts using 3DP, if used incorrectly this can be detrimental and result in unnecessary costs or delays for a project. By following a Design for Additive Manufacturing (DfAM) approach such limitations can be mitigated allowing for rapid prototyping and advancements in product development. This seminar will clear up some misconceptions regarding 3DP, discuss the benefits of a DfAM approach and highlight some exciting new opportunities currently being explored at The University of Auckland's Creative Design and Additive Manufacturing Lab. https://cassyni-user-files-prod.s3.amazonaws.com/XdRdzmUJpjpUwQFv7JuD8i https://cassyni.com/slides/outline/4RDoiGeQnAFcCQeQxV6GTP https://cassyni.com/events/4RDoiGeQnAFcCQeQxV6GTP/abstract https://cassyni-user-files-prod.s3.amazonaws.com/NsvxELp6epb9243T7jbn5t https://cassyni.com/events/4RDoiGeQnAFcCQeQxV6GTP?videoPreview=1 Multiple scattering analysis of quasi-periodic clusters of scatterersnohttps://cassyni.com/events/4RDoiGeQnAFcCQeQxV6GTP?videoPreview=12021-11-30T14:00:00+00:004410.84MetaMATWe will apply multiple scattering theory to the analysis of resonant modes of finite clusters of scatterers for flexural waves. It will be shown that this method allows the calculation of the real and imaginary part of the eigenfrequencies of finite structures, so that we can determine not only the resonant frequency but also its quality factor. We will apply this method to the study of two-dimensional clusters forming moiré lattices and to the quasi periodic infinite line, showing that both types of structures present a large amount of resonances of high quality. It will be shown therefore that quasi-periodic clusters are a promising family of structures for the design of wave-localization devices, since these results are in principle applicable to any kind of classical wave. https://cassyni-user-files-prod.s3.amazonaws.com/NsvxELp6epb9243T7jbn5t https://cassyni.com/slides/outline/6tSCq4N9a66NQsRaDc4TYh https://cassyni.com/events/6tSCq4N9a66NQsRaDc4TYh/abstract https://cassyni-user-files-prod.s3.amazonaws.com/CUn3oyVMWjWKR9unQ3zqvv https://cassyni.com/events/6tSCq4N9a66NQsRaDc4TYh?videoPreview=1 High order numerical methods for fractional diffusion in polygonsnohttps://cassyni.com/events/6tSCq4N9a66NQsRaDc4TYh?videoPreview=12021-03-04T15:00:00+00:003478.32Partial Differential Equations and ApplicationsNo abstracthttps://cassyni-user-files-prod.s3.amazonaws.com/CUn3oyVMWjWKR9unQ3zqvv https://cassyni.com/slides/outline/QfqCivgpBHt5iudymijxuT https://cassyni.com/events/QfqCivgpBHt5iudymijxuT/abstract https://cassyni-user-files-prod.s3.amazonaws.com/5QViTJk1vCWC9VEQ2mxyj4 https://cassyni.com/events/QfqCivgpBHt5iudymijxuT?videoPreview=1 Partial order can make photonic nanomaterials differentnohttps://cassyni.com/events/QfqCivgpBHt5iudymijxuT?videoPreview=12022-04-05T13:00:00+00:004653.12MetaMATLight scattering from disordered materials has been extensively studied, but the influence of short and long-range spatial correlations in the disorder has been often overlooked. The possibility to engineer partially ordered materials (i.e. between completely amorphous and perfectly periodic) opens new perspectives for the control of light-matter interaction. We will discuss light propagation and absorption in partially ordered materials made of discrete scatterers in a transparent matrix. As an example, we will show that transparency, or almost perfect absorption, is expected for a specific type of partial order known as hyperuniform disorder. Finally, we will present recent approaches to the fabrication of partially ordered materials by bottom-up self-organization processes.https://cassyni-user-files-prod.s3.amazonaws.com/5QViTJk1vCWC9VEQ2mxyj4 https://cassyni.com/slides/outline/FHV6jJsxSES5igUSa2KxQD https://cassyni.com/events/FHV6jJsxSES5igUSa2KxQD/abstract https://cassyni-user-files-prod.s3.amazonaws.com/BNPLBcqEEXghBAbPRx5CC6 https://cassyni.com/events/FHV6jJsxSES5igUSa2KxQD?videoPreview=1 Computing multiple solutions of PDEs with deflationnohttps://cassyni.com/events/FHV6jJsxSES5igUSa2KxQD?videoPreview=12022-06-15T15:00:00+00:002387.4Department of AeronauticsComputing the distinct solutions $u$ of an equation $f(u, \lambda) = 0$ as a parameter $\lambda \in \mathbb{R}$ is varied is a central task in applied mathematics and engineering. The solutions are captured in a bifurcation diagram, plotting (some functional of) $u$ as a function of $\lambda$. In this talk I will present a useful idea, deflation, for this task. Deflation has three main advantages. First, it is capable of computing disconnected bifurcation diagrams; previous algorithms only aimed to compute that part of the bifurcation diagram continuously connected to the initial data. Second, its implementation is very simple: it only requires a minor modification to an existing Newton-based solver. Third, it can scale to very large discretisations if a good preconditioner is available; no auxiliary problems must be solved. We will present applications to hyperelastic structures, liquid crystals, and Bose-Einstein condensates, and discuss how PDE-constrained optimisation problems may be solved to design systems with certain bifurcation properties. https://cassyni-user-files-prod.s3.amazonaws.com/BNPLBcqEEXghBAbPRx5CC6 https://cassyni.com/slides/outline/HknNBz9MSF4PnLSb1fFJdb https://cassyni.com/events/HknNBz9MSF4PnLSb1fFJdb/abstract https://cassyni-user-files-prod.s3.amazonaws.com/A6xpPNVroxx3XKM1meFxgE https://cassyni.com/events/HknNBz9MSF4PnLSb1fFJdb?videoPreview=1 Bridging Art and Mathematics: Some Case Studies in STEAM Spiritnohttps://cassyni.com/events/HknNBz9MSF4PnLSb1fFJdb?videoPreview=12021-02-27T18:30:00+00:001481.04Mathematical IntelligencerNo abstracthttps://cassyni-user-files-prod.s3.amazonaws.com/A6xpPNVroxx3XKM1meFxgE https://cassyni.com/slides/outline/QB9yZcXQLUQFuSeTycczjF https://cassyni.com/events/QB9yZcXQLUQFuSeTycczjF/abstract https://cassyni-user-files-prod.s3.amazonaws.com/GZCBAo8EqqVmQkxHhCNTC2 https://cassyni.com/events/QB9yZcXQLUQFuSeTycczjF?videoPreview=1 Data-driven Control of General Linear Systems – Extensions of the Fundamental Lemma for Stochastic and Descriptor Settingsnohttps://cassyni.com/events/QB9yZcXQLUQFuSeTycczjF?videoPreview=12022-03-09T16:00:00+00:002807.28Department of AeronauticsThe fundamental lemma proposed by Jan Willems and co-authors in 2005 [1] is pivotal for many recent research efforts on data-driven control. It states that, under suitable assumptions, any input-output trajectory of a linear time-invariant (LTI) system can be described as a linear combination of previously recorded trajectories. Recently, there have been several extensions of the fundamental lemma, e.g., to linear-parameter varying systems and to nonlinear systems. Moreover, predictive control based on such non-parametric system descriptions is receiving substantial research interest [2,3]. In this talk, we discuss progress of data-driven predictive control with respect to LTI systems in stochastic and descriptor settings. First, we consider the question of how to extend the fundamental lemma to regular descriptor systems [4]. Subsequently, we turn to the stochastic setting. To this end, we revisit polynomial chaos expansions (PCE) of L2 random variables, the origins of which date back to Norbert Wiener [5]. We show that under mild assumptions, stochastic extensions to Willems’ fundamental lemma can be derived either in the PCE framework or relying on past realization trajectories of inputs, states, and process noise [6]. Specifically, we illustrate that the knowledge of past noise realizations allows the construction of Hankel matrices which, upon leveraging PCE representations of random variables, enable forward propagation of distributions, without knowledge of any parametric system description. In the final part of the talk, we turn towards data-driven stochastic MPC. We show that the proposed non-parametric system description can be used in a stochastic optimal control problem. Our findings will be illustrated by examples from different applications. https://cassyni-user-files-prod.s3.amazonaws.com/GZCBAo8EqqVmQkxHhCNTC2 https://cassyni.com/slides/outline/9rMTDnmBcCM1KpECy7LAQm https://cassyni.com/events/9rMTDnmBcCM1KpECy7LAQm/abstract https://cassyni-user-files-prod.s3.amazonaws.com/6m1cN3LvThHzm8fuA8CuLz https://cassyni.com/events/9rMTDnmBcCM1KpECy7LAQm?videoPreview=1 Connecting to Figure Out How to Teach ESOL: A Grounded Theorynohttps://cassyni.com/events/9rMTDnmBcCM1KpECy7LAQm?videoPreview=12022-06-17T04:00:00+00:002950.36Linguistics and Applied Language StudiesWhat can we learn from people who taught themselves how to teach ESOL? This PhD research explored how teachers who started teaching English to Speakers of Other Languages (ESOL) in post-secondary education without teaching or applied linguistics qualifications or prior teaching experience figured out how to teach. Grounded theory was used to explore the social context and guide cyclic, flexible research processes. Seven participants shared their perspectives during semi-structured interviews. Constant comparative analysis was used to identify properties, concepts, categories, a basic social process, and a grounded theory. The substantive grounded theory of Connecting to Figure Out How to Teach ESOL explains how teachers who started teaching ESOL in post-secondary education without teaching or applied linguistics qualifications or prior teaching experience discovered and determined how to teach ESOL. Connecting to Figure Out How to Teach ESOL is an informal and holistic learning process that includes four interdependent and interconnecting parts: becoming (a) Willing by initially acknowledging not-knowing how to teach and taking responsibility for students’ learning; (b) Reflecting by recalling learning experiences, and evaluating language, learning and teaching; (c) Engaging by building relationships with students, collaborating with teachers, and using learning resources; and (d) Adapting by engaging in interconnected cycles of monitoring students’ responses, determining students’ wants and needs, and experimenting with teaching.https://cassyni-user-files-prod.s3.amazonaws.com/6m1cN3LvThHzm8fuA8CuLz https://cassyni.com/slides/outline/RAWRtErE27NEGuy3yY733b https://cassyni.com/events/RAWRtErE27NEGuy3yY733b/abstract https://cassyni-user-files-prod.s3.amazonaws.com/4wtarYsbpW4TWL4YJnqyt2 https://cassyni.com/events/RAWRtErE27NEGuy3yY733b?videoPreview=1 Women 'readings' of Aotearoa New Zealandnohttps://cassyni.com/events/RAWRtErE27NEGuy3yY733b?videoPreview=12022-05-18T04:30:00+00:003546.84Stout Research Centre for New Zealand StudiesThis seminar discusses what it means to be a women writer in Aotearoa New Zealand but also about the pleasures of reading women's New Zealand fiction. The panelists discuss their own take on writing about, and in, Aotearoa New Zealand, reflection on Lydia's reading tastes, their reading tastes, and memories of their favourite writers growing up.https://cassyni-user-files-prod.s3.amazonaws.com/4wtarYsbpW4TWL4YJnqyt2 https://cassyni.com/events/KjMAG6DZniM4KovdmF2yBK/abstract https://cassyni-user-files-prod.s3.amazonaws.com/5VAfhqBzx5im7KR3fjfCht https://cassyni.com/slides/outline/SeRcufGuw86qpcvD8gbuL1 https://cassyni.com/events/SeRcufGuw86qpcvD8gbuL1/abstract https://cassyni-user-files-prod.s3.amazonaws.com/HByKF7m2Hz3CrE6xqd2UKQ https://cassyni.com/events/SeRcufGuw86qpcvD8gbuL1?videoPreview=1 RNA-dependent RNA Ploymerase of SARS-CoV-2 as an Attractive Drug Target to Contain COVID-19nohttps://cassyni.com/events/SeRcufGuw86qpcvD8gbuL1?videoPreview=12022-06-09T09:30:00+00:004073.76Chemical Physics ImpactThe recent outbreak of COVID-19 has affected the lives and economies of several countries. Although the developments of vaccines have created a preventive measure against this disease, there is no approved drug available to date for the treatment of the disease. Therefore, it is imperative to design drugs that can specifically target the key viral proteins of the SARS-CoV-2 that cause COVID-19. To do so it is desirable to understand the structure and function of these proteins that are mainly involved in causing and spreading the virus. Here, emphasis will be given to understanding the structure and function of the RNA-dependent RNA polymerase (RdRp) that is mainly responsible for the replication of the virus inside host cells. Different strategies to inhibit the activities of RdRp will be discussed in detail. The mechanisms of drug action and the drug repurposing results against the RdRp will also be discussed. https://cassyni-user-files-prod.s3.amazonaws.com/HByKF7m2Hz3CrE6xqd2UKQ https://cassyni.com/slides/outline/2Sf1eAaCRgxwewANCuJbuf https://cassyni.com/events/2Sf1eAaCRgxwewANCuJbuf/abstract https://cassyni-user-files-prod.s3.amazonaws.com/7jsmw8uQaaUFLTguR2Hyav https://cassyni.com/events/2Sf1eAaCRgxwewANCuJbuf?videoPreview=1 Interaction between wave-induced nearbed vortex structures and cohesionless sediments: numerical resultsnohttps://cassyni.com/events/2Sf1eAaCRgxwewANCuJbuf?videoPreview=12022-04-12T10:40:00+00:001711.04Water WavesIn the framework of the research project “FUNdamentals of BREAKing wave-induced boundary dynamics” (FUNBREAK) and of the ONR Global research project aw. nr. N62909-17-1-2144, we performed and analysed direct numerical simulations of the turbulent oscillatory flow generated close to the bottom by the propagation of surface waves. The bottom was composed of cohesionless spherical particles which are free to move when dragged by the surrounding fluid. The hydrodynamic stress over the surface of each sediment grain was explicitly computed by means of the immersed boundary approach. Hence, the force and torque acting on the sediment grains were readily evaluated. Numerical simulations were made for a range of flow Reynolds numbers and sediment particle dimensions that are typical of shallow coastal areas. An example of the results is given in the figure where the instantaneous position of the sediment grains is plotted along with the turbulent vortex structures generated by the interaction of the turbulent eddies with the spherical particles. The results were used to develop and test physically based models for bedload transport and reference bed concentration of suspended sediment in oscillatory flow.https://cassyni-user-files-prod.s3.amazonaws.com/7jsmw8uQaaUFLTguR2Hyav https://cassyni.com/slides/outline/FnAKtd3NH3uuY9TxN8SvaR https://cassyni.com/events/FnAKtd3NH3uuY9TxN8SvaR/abstract https://cassyni-user-files-prod.s3.amazonaws.com/B637EvsrvjbwvYaHvr3cCv https://cassyni.com/events/FnAKtd3NH3uuY9TxN8SvaR?videoPreview=1 k-Provability in PAnohttps://cassyni.com/events/FnAKtd3NH3uuY9TxN8SvaR?videoPreview=12021-10-06T10:40:00+00:003535.32Logica UniversalisWe study the decidability of k-provability in $\hbox {PA}$—the relation ‘being provable in $\hbox {PA}$ with at most k steps’—and the decidability of the proof-skeleton problem—the problem of deciding if a given formula has a proof that has a given skeleton (the list of axioms and rules that were used). The decidability of k-provability for the usual Hilbert-style formalisation of $\hbox {PA}$ is still an open problem, but it is known that the proof-skeleton problem is undecidable for that theory. Using new methods, we present a characterisation of some numbers k for which k-provability is decidable, and we present a characterisation of some proof-skeletons for which one can decide whether a formula has a proof whose skeleton is the considered one. These characterisations are natural and parameterised by unification algorithms.https://cassyni-user-files-prod.s3.amazonaws.com/B637EvsrvjbwvYaHvr3cCv https://cassyni.com/slides/outline/U8KBpTBiSmugYdQk6AGbhX https://cassyni.com/events/U8KBpTBiSmugYdQk6AGbhX/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Nn7RMRULwMRixsaEjJL7D8 https://cassyni.com/events/U8KBpTBiSmugYdQk6AGbhX?videoPreview=1 12 Labours Seminar Series (Exemplar Project 3): Uterine function: An experimental and computational challengenohttps://cassyni.com/events/U8KBpTBiSmugYdQk6AGbhX?videoPreview=12022-08-03T00:00:00+00:003627.68Auckland Bioengineering InstituteNo abstracthttps://cassyni-user-files-prod.s3.amazonaws.com/Nn7RMRULwMRixsaEjJL7D8 https://cassyni.com/slides/outline/NhGQepcbppbRBS9w28xJMj https://cassyni.com/events/NhGQepcbppbRBS9w28xJMj/abstract https://cassyni-user-files-prod.s3.amazonaws.com/U7UfbUJfE7Hdbogs8wdkPx https://cassyni.com/events/NhGQepcbppbRBS9w28xJMj?videoPreview=1 Superphanes: Facile and Efficient Preparation, Functionalization and Unique Propertiesnohttps://cassyni.com/events/NhGQepcbppbRBS9w28xJMj?videoPreview=12022-07-18T12:00:00+00:003163.08Tetrahedron Chem and Tetrahedron Green ChemSuperphanes, compounds in which the two benzene rings clamped parallel on top of each other by six bridges, have been attracting considerable interest because of their structural beauty and symmetry. However, progress in the research of superphane chemistry and beyond has been seriously hampered by their poor availability. Herein, we report the facile and scalable synthesis of a collection of superphanes with structural diversity and their unique photophysical properties, as well as their unusual host–guest behavior. A set of secondary amine–linked superphanes are obtained via dynamic self–assembly of a hexakis–amine and various readily derived aromatic dialdehyde in one pot, followed by in–situ reduction with NaBH4. Further post–functionalization was exemplified by secondary amine to tertiary amine conversion. All superphanes under study were found to exhibit interesting fluorescence either in solution or in the solid state. Finally, the unusual host–guest binding properties was exemplified by the stabilization of a labile 2Cl–⋅H2O cluster with fully protonated 6a both in solution and in the solid state. With the easy and versatile synthesis, modification, as well as unique photophysical and host–guest properties reported herein, we believe that this study offers new possibilities for superphane chemistry, supramolecular host design, advanced functional materials and beyond.https://cassyni-user-files-prod.s3.amazonaws.com/U7UfbUJfE7Hdbogs8wdkPx https://cassyni.com/slides/outline/3RyqrAP8hxzpUAgmbSiNMB https://cassyni.com/events/3RyqrAP8hxzpUAgmbSiNMB/abstract https://cassyni-user-files-prod.s3.amazonaws.com/7DSHNDxLVBf6xmwwT7o3cS https://cassyni.com/events/3RyqrAP8hxzpUAgmbSiNMB?videoPreview=1 Modern approaches to study nausea and emesis and gastric function using radiotelemetry and the microelectrode arraynohttps://cassyni.com/events/3RyqrAP8hxzpUAgmbSiNMB?videoPreview=12022-09-06T04:00:00+00:004098.96The Auckland Bioengineering InstituteDetecting emetic liability of new clinical entities is challenging particularly since common laboratory animals (e.g. mouse, rat) are incapable of vomiting. It is even more challenging to detect ‘nausea’ in animals, regardless if they vomit or not. Studies to record behaviour are relatively straightforward to conduct, but advances have been made recently by the simultaneous use of radiotelemetry to record biopotentials to provide information relative to the gastrointestinal tract (myoelectric activity) and cardiovascular system, in conjunction with whole body plethysmography to record respiratory function. Gastrointestinal (GI) pacemaker activity, or slow-wave, is low-frequency electrical current produced by the Interstitial cells of Cajal. We have optimized a standardized methodology in recording extracellular GI pacemaker activity using the microelectrode array (MEA) technique. The MEA make use of a chip with 60 microelectrodes arrayed on a glass surface to allow derivation of networking behaviour of pacemaker activity using isolated GI tissues. We validated the data through testing basic pacemaker electrophysiology. The technique was further applied in drug testing and screening to reveal the correlations of GI pacemaker activity in health and disease. We also automated the analytical pipeline to pick up slow wave features, including frequency, power distribution, signal complexity and propagation pattern across the 60-electrode raw recordings, which derive a comprehensive “electrical” drug profile. We had tested over 140 drugs now, creating a unique “bio-electrical” drug database to be applied in future artificial intelligence drug discovery project. https://cassyni-user-files-prod.s3.amazonaws.com/7DSHNDxLVBf6xmwwT7o3cS https://cassyni.com/slides/outline/W6zUM5KUQguFg1gPz1p2mj https://cassyni.com/events/W6zUM5KUQguFg1gPz1p2mj/abstract https://cassyni-user-files-prod.s3.amazonaws.com/XdewHwdcML28gJ85JobWdL https://cassyni.com/slides/outline/QBaKH4FhNtJA6c6VG8hdCZ https://cassyni.com/events/QBaKH4FhNtJA6c6VG8hdCZ/abstract https://cassyni-user-files-prod.s3.amazonaws.com/EAtrkzS9FV2Mc2ohQHPLPg https://cassyni.com/events/QBaKH4FhNtJA6c6VG8hdCZ?videoPreview=1 Genomic, functional, and metabolic enhancements in multidrug-resistant Enterobacter bugandensis facilitating its persistence and succession in the International Space Stationnohttps://cassyni.com/events/QBaKH4FhNtJA6c6VG8hdCZ?videoPreview=12025-01-21T15:00:00+00:00869.04Microbiome Virtual International ForumThe International Space Station (ISS) stands as a testament to human achievement in space exploration. Despite its highly controlled environment, characterised by microgravity, increased CO2 levels, and elevated solar radiation, microorganisms occupy a unique niche. These microbial inhabitants play a significant role in influencing the health and well-being of astronauts on board. One microorganism of particular interest in our study is Enterobacter bugandensis, primarily found in clinical specimens including the human gastrointestinal tract, and also reported to possess pathogenic traits, leading to a plethora of infections. During the 2-year Microbial Tracking 1 mission, 13 strains of multidrug-resistant E. bugandensis were isolated from various locations within the ISS. We have carried out a comprehensive study to understand the genomic intricacies of ISS-derived E. bugandensis in comparison to terrestrial strains, with a keen focus on those associated with clinical infections. We unravel the evolutionary trajectories of pivotal genes, especially those contributing to functional adaptations and potential antimicrobial resistance. A hypothesis central to our study was that the singular nature of the stresses of the space environment, distinct from any on Earth, could be driving these genomic adaptations. Extending our investigation, we meticulously mapped the prevalence and distribution of E. bugandensis across the ISS over time. This temporal analysis provided insights into the persistence, succession, and potential patterns of colonisation of E. bugandensis in space. Furthermore, by leveraging advanced metabolic modelling, we delved into the coexisting microbial communities alongside E. bugandensis in the ISS across multiple missions and spatial locations. This exploration revealed intricate microbial interactions, offering a window into the microbial ecosystem dynamics within the ISS. Our comprehensive analysis illuminated not only the ways these interactions sculpt microbial diversity but also the factors that might contribute to the potential dominance and succession of E. bugandensis within the environment. The implications of these findings are twofold. Firstly, they shed light on microbial behaviour, adaptation, and evolution in extreme, isolated environments. Secondly, they underscore the need for robust preventive measures, ensuring the health and safety of astronauts by mitigating risks associated with potential pathogenic threats.https://cassyni-user-files-prod.s3.amazonaws.com/EAtrkzS9FV2Mc2ohQHPLPg https://cassyni.com/events/AMUeDBAmtneWA98NFQMvyB/abstract https://cassyni-user-files-prod.s3.amazonaws.com/PiSjws7vkZGWqtJgsbW2Uv https://cassyni.com/events/T9VZfnejQzYo1Yu81dyL4d/abstract https://cassyni-user-files-prod.s3.amazonaws.com/NGsBBnrdY8J4Z6uua75VJv https://cassyni.com/slides/outline/4vKNb2Y7fPdLD35x37Hs6u https://cassyni.com/events/4vKNb2Y7fPdLD35x37Hs6u/abstract https://cassyni-user-files-prod.s3.amazonaws.com/6rETYkfrh5QWFLXzHmQDne https://cassyni.com/events/4vKNb2Y7fPdLD35x37Hs6u?videoPreview=1 Open Hardware Makers, A Training Program For Developing Open Science Hardwarenohttps://cassyni.com/events/4vKNb2Y7fPdLD35x37Hs6u?videoPreview=12024-12-12T06:00:00+00:002728.76UKRNResearch in all fields requires dedicated equipment and tools, which are a lot of times, expensive, proprietary and hard to customise. In line with other Open Research efforts, Open Hardware has emerged as an answer to these shortcomings, where hardware developers freely share the documentation needed for scrutiny, replication and customisation of research tools. Examples range from interactive art pieces to microscopes able to measure details in atomic level. However, being a newish field in Open Research, there isn’t widespread knowledge on best practices, or even what kind of files should be shared and how. In this event attendees will learn more details about “Open Hardware Makers – UKRN edition” a mentoring program that guides hardware developers through best practices and community guidelines to make their projects open, sustainable and successful. Moreover, they will also get training on how to train others themselves, making them “open hardware champions” on their local communities.https://cassyni-user-files-prod.s3.amazonaws.com/6rETYkfrh5QWFLXzHmQDne https://cassyni.com/events/YaeqHwHPePZeE7bypDoHxy/abstract https://cassyni-user-files-prod.s3.amazonaws.com/VQRKiBZqP2haDEM6D3jKRx https://cassyni.com/slides/outline/3w5QivGqbCNYUo8Jg4uxzh https://cassyni.com/events/3w5QivGqbCNYUo8Jg4uxzh/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Kn2ehqot6Kje66a8ZDh6p6 https://cassyni.com/events/3w5QivGqbCNYUo8Jg4uxzh?videoPreview=1 Semi-automatic Calculations of Multi-loop Feynman Amplitudes with AmpRednohttps://cassyni.com/events/3w5QivGqbCNYUo8Jg4uxzh?videoPreview=12025-08-29T15:56:49+00:002700.0Computer Physics CommunicationsWe present a Mathematica package AmpRed for the semi-automatic calculations of multi-loop Feynman amplitudes with high efficiency and precision. AmpRed implements the methods of integration by parts and differential equations in the Feynmanparameter representation. It allows for the calculations of general parametric integrals (which may not have momentum-space correspondences). Various user-friendly tools for multi-loop calculations, such as those to construct and solve differential equations for Feynman integrals, are provided. It can also deal with tensor algebras in non-relativistic eld theories. Interfaces to some packages, like QGRAF and FORM, are also provided.https://cassyni-user-files-prod.s3.amazonaws.com/Kn2ehqot6Kje66a8ZDh6p6 https://cassyni.com/slides/outline/6tYhHaRhBXoGzUdLQ3Ctr1 https://cassyni.com/events/6tYhHaRhBXoGzUdLQ3Ctr1/abstract https://cassyni-user-files-prod.s3.amazonaws.com/X1XY7QRHomVteSZCs3a2hc https://cassyni.com/events/6tYhHaRhBXoGzUdLQ3Ctr1?videoPreview=1 Foraging and thermally-induced phenotypic plasticity interact in the most northerly distributed freshwater fishnohttps://cassyni.com/events/6tYhHaRhBXoGzUdLQ3Ctr1?videoPreview=12025-09-09T13:00:00+00:00825.92Royal Society PublishingForaging and thermally-induced phenotypic plasticity interact in the most northerly distributed freshwater fish. Elevated temperatures from climate change are predicted to be more extreme at higher latitudes. This could require phenotypic plasticity to generate variation that allows organisms to persist in these regions. However, climate change will provide a multifactorial change in environmental cues, making an understanding of how theyinteract essential for predicting persistence and future evolutionary potential. Here, the impacts of temperature on ecologically relevant phenotypic plasticity (foraging environment) in Arctic charr (Salvelinus alpinus) was studied. Eggs and alevins were kept at the same temperature (9°C) and split using a factorial design. This included two temperature treatments (10°C and 14°C) and two treatments representing benthic and pelagic foraging styles. We measured morphology in response to these treatment combinations and found an interaction between foraging and temperature-induced plasticity in body shape that included changes in body depth and the caudal peduncle that could impact swimming ability and fitness. This indicates that thermal conditions may change how plasticity responds to ecological conditions and impacts adaptive variation.https://cassyni-user-files-prod.s3.amazonaws.com/X1XY7QRHomVteSZCs3a2hc https://cassyni.com/slides/outline/9MniWzfKNpa65xSTMSMdXs https://cassyni.com/events/9MniWzfKNpa65xSTMSMdXs/abstract https://cassyni-user-files-prod.s3.amazonaws.com/DkhrSkU8axMtGWDBvG5yCJ https://cassyni.com/events/9MniWzfKNpa65xSTMSMdXs?videoPreview=1 The influence of rurality on women's decision making and pregnancy choices following an unintended pregnancy: A systematic reviewnohttps://cassyni.com/events/9MniWzfKNpa65xSTMSMdXs?videoPreview=12025-06-25T06:00:00+00:001057.04Women's Health**Background** Almost half of all pregnancies worldwide and 34% of pregnancies in high income countries (HIC) are considered unintended. Several studies from HIC report that women from rural areas are more likely to continue their unintended pregnancy and give birth, while urban women are more likely to have an induced abortion. **Objectives** To explore how rurality influences women's decision-making and pregnancy choices following unintended pregnancy by examining the global trends for women who reside in rural areas of HIC. **Design** This study is a systematic review of qualitative, cross-sectional and mixed-methods studies **Data Sources and Methods** A systematic review of peer-reviewed literature, published from January 2000 through to March 2024, retrieved from five databases: CINAHL, Embase, MEDLINE, PsycINFO and PubMed. Restrictions were applied to obtain original research that has been undertaken in high-income countries. The review included studies featuring participants that were either rural women who experience an unintended pregnancy or health care professionals providing direct care to rural women. Nineteen studies met the inclusion criteria and were included in this review. **Results** Several factors that influence rural women's decision-making following an unintended pregnancy were identified: access to abortion services; role of health care professionals; temporal factors; social norms and stigma; social factors and determinants; culture, ethnicity and religion; reproductive coercion; and abortion legislation. The Social-Ecological Model highlighted the levels of interaction, the role health care professionals, family members and the wider community in supporting or obstructing rural women’s decision-making. **Conclusion** Despite women in rural areas being more likely to continue an unintended pregnancy, findings of this review indicate that it is not always personal choice as family members and health professionals can influence pregnancy outcome decisions, and while some women may feel supported to continue a pregnancy, others report experiencing barriers to accessing abortion services. **Registration** PROSPERO CRD 42023409917https://cassyni-user-files-prod.s3.amazonaws.com/DkhrSkU8axMtGWDBvG5yCJ https://cassyni.com/events/T9BiQryyz2MoPzeruZ38td/abstract https://cassyni-user-files-prod.s3.amazonaws.com/29U9rgmJGhMGEkSVYR5VS6 https://cassyni.com/events/9qQHLPF3uvrJJrHxbFw9u7/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Ro8VtWdZcBC4L2tKcBf76v https://cassyni.com/slides/outline/AL78cKvMA7FtxKKwYsVdDP https://cassyni.com/events/AL78cKvMA7FtxKKwYsVdDP/abstract https://cassyni-user-files-prod.s3.amazonaws.com/5ekzwWYRYpcFNEw2onDuMQ https://cassyni.com/events/AL78cKvMA7FtxKKwYsVdDP?videoPreview=1 Microbiome Geographic Population Structure (mGPS): A Powerful Tool for Microbial Forensicsnohttps://cassyni.com/events/AL78cKvMA7FtxKKwYsVdDP?videoPreview=12025-11-12T15:00:00+00:00924.84Microbiome Virtual International ForumTrace evidence analysis is a specialized forensic science discipline that examines and interprets material transfers between objects, individuals, and environments using sources like hair, fibers, soil, and pollen. Identifying the recent geographic whereabouts of organisms has been challenging in ecology, microbiology, and forensics due to difficulties in uniquely associating biological material with specific sites. While human DNA can predict origins, it has limited forensic value as it remains constant and does not indicate recent movements. Only dynamic spatio-temporal types of information shared and exchanged between organisms and the environment can be used by tracing applications. However, no microbial biogeographical applications are available, and localizing microbes remains an unresolved challenge. We developed the Microbiome Geographic Population Structure (mGPS), the first machine-learning-based tool that leverages microbial relative sequence abundances to pinpoint the fine-scale source locations of microorganisms. mGPS was rigorously tested on microbiomes from the built (MetaSUB project), soil (Soil Atlas project), and marine (Tara Ocean) environments sequenced using different approaches. Applied to 40 global cities, mGPS predicted the sampling sites for 92% of the samples. At the resolution of a single city, mGPS predicted up to 82% of sampling sites, which often were only a few hundred meters apart. Applied to soil and marine microbiomes, mGPS predicted the sampling sites for 86% and 74% of the samples, respectively. We demonstrated that mGPS differentiated local from non-local microorganisms and used it to trace the global spread of antimicrobial resistance genes. mGPS’s ability to localize samples to their waterbody, country, city, and transit stations has forensics, medical, and epidemiological applications.https://cassyni-user-files-prod.s3.amazonaws.com/5ekzwWYRYpcFNEw2onDuMQ https://cassyni.com/slides/outline/VbLTBj83UEzx1tJ1cPTtAy https://cassyni.com/events/VbLTBj83UEzx1tJ1cPTtAy/abstract https://cassyni-user-files-prod.s3.amazonaws.com/XnEaEkik2DkATMbAaDq1RG https://cassyni.com/events/VbLTBj83UEzx1tJ1cPTtAy?videoPreview=1 Pregnancy and Breast Cancer in Young Womennohttps://cassyni.com/events/VbLTBj83UEzx1tJ1cPTtAy?videoPreview=12025-09-10T08:11:01+00:00771.88Sage PublishingThe relationship between pregnancy and breast cancer is complicated. On one hand, pregnancy can influence breast cancer risk and tumor biology, and on the other, a breast cancer diagnosis and its subsequent management can significantly affect fertility, family planning, and future pregnancies. This interaction presents challenges unique to young women with breast cancer (YWBC). This review provides an updated overview of YWBC, and pregnancy associated breast cancer (PABC), including the rising prevalence of YWBC, current understanding of the biology of PABC and its subtypes, and the management of PABC. We address the critical issue of how breast cancer treatment impacts family planning and future pregnancies, including current data on interrupting endocrine treatment for pregnancy. Additionally, we examine recent advancements in early-stage breast cancer as well as gaps in knowledge regarding how targeted treatments affect ovarian reserve. Finally, we highlight key areas of future research that could improve the prevention, management, and understanding of cancer treatment’s impact on fertility in YWBC.https://cassyni-user-files-prod.s3.amazonaws.com/XnEaEkik2DkATMbAaDq1RG https://cassyni.com/slides/outline/Y4c6XmsZ4thDCpp3Kap22y https://cassyni.com/events/Y4c6XmsZ4thDCpp3Kap22y/abstract https://cassyni-user-files-prod.s3.amazonaws.com/MGtz9NsV7hyqgv9MXxGeDk https://cassyni.com/events/Y4c6XmsZ4thDCpp3Kap22y?videoPreview=1 Set-based Online Adversarial Control of Unknown Systemsnohttps://cassyni.com/events/Y4c6XmsZ4thDCpp3Kap22y?videoPreview=12025-10-23T19:00:00+00:003069.76AI Institute in Dynamic SystemsThe next generation of Cyber-Physical Systems (CPS) is large-scale, safety-critical, and time-varying. Therefore, we must design practical control algorithms that enable CPS that are scalable and robust to uncertainties, with fast adaptation. Towards this, I will introduce a novel uncertainty set-based online adaptive control framework that leverages online learning techniques (e.g., convex online optimization) and control methods (e.g., distributed control and MPC) that enable novel safety guarantees for unknown systems under non-stochastic and potentially adversarial disturbances. In this talk, I will outline adversarial stability results for learning-based control in (i) unknown time-varying systems and (ii) unknown large-scale networked systems with communication constraints. Applications of the framework include voltage regulation in power distribution grids and comfort-constrained HVAC control. Experiments on realistic nonlinear simulations with real-world data confirm that the approach remains effective under practical conditions.https://cassyni-user-files-prod.s3.amazonaws.com/MGtz9NsV7hyqgv9MXxGeDk https://cassyni.com/events/SdUT2FknErc8oxZoifpE3X/abstract https://cassyni-user-files-prod.s3.amazonaws.com/JiNR2kPFNBYx6fxEEXKkgn https://cassyni.com/events/3R2fxks11hW7TWLNBRvh4h/abstract https://cassyni-user-files-prod.s3.amazonaws.com/5a8vECbmCgzV7om9K3b5Qi https://cassyni.com/slides/outline/4te1jFcwVk3jPf3GEVVNB7 https://cassyni.com/events/4te1jFcwVk3jPf3GEVVNB7/abstract https://cassyni-user-files-prod.s3.amazonaws.com/R1FKL3Qh83Y2FzeuUNgtS2 https://cassyni.com/events/4te1jFcwVk3jPf3GEVVNB7?videoPreview=1 VQA_POISSON: A Quantum Library for Solving Two-Dimensional Poisson Equations with Mixed Boundary Conditionsnohttps://cassyni.com/events/4te1jFcwVk3jPf3GEVVNB7?videoPreview=12026-03-04T08:00:00+00:001272.36Computer Physics CommunicationsVariational quantum algorithms (VQAs) have emerged as promising approaches for solving partial differential equations on near-term quantum hardware, offering hybrid optimization schemes that are robust to noise. A key challenge lies in balancing decomposition complexity and circuit depth: reducing the number of unitary terms lowers measurement cost but increases circuit depth, thereby amplifying hardware-induced noise. This work benchmarks three VQA-based solvers for the Poisson equation—Permutation Operator (PO), Sparse Decomposition (SD), and Fourier Diagonalization (FD) methods—all built on a common cost function. The FD method, in particular, leverages the Quantum Fourier Transform to diagonalize circulant Laplacians, enabling a decomposition with only one term per spatial dimension. The trade-off between gate count and noise resilience is systematically analyzed under realistic hardware constraints, including limited qubit connectivity and native gate sets. Empirical results on IBM quantum hardware indicate that while the FD method achieves superior cost scaling and requires fewer measurements, its deeper circuits are more sensitive to hardware noise. In contrast, the SD method provides better noise resilience with shallower circuits, but at the expense of a larger number of measurements. To facilitate reproducibility and further research, an open-source Qiskit-based library is provided for solving Poisson equations with mixed boundary conditions, supporting both IonQ simulators and IBM devices.https://cassyni-user-files-prod.s3.amazonaws.com/R1FKL3Qh83Y2FzeuUNgtS2 https://cassyni.com/events/ApUWWiR1ZxYjAE5CEtgQDb/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Rmzz2LpuUEYLv6ipgjFxLe https://cassyni.com/slides/outline/GFcA2EXnPzdoZ6KRqogCD3 https://cassyni.com/events/GFcA2EXnPzdoZ6KRqogCD3/abstract https://cassyni-user-files-prod.s3.amazonaws.com/QFG7xJs3qu6kDCBBKFiHZQ https://cassyni.com/events/GFcA2EXnPzdoZ6KRqogCD3?videoPreview=1 Blood-derived Progenitors for Transplantations at 40 nohttps://cassyni.com/events/GFcA2EXnPzdoZ6KRqogCD3?videoPreview=12026-05-04T10:00:00+00:002074.32Bone Marrow TransplantationFebruary, 2026 is the 40th anniversary of the 1st publication of rapid recovery of bone marrow function after high-dose chemotherapy and infusion of an autologous blood- rather than a bone-marrow-derived graft. The recipient, a man with advanced Burkitt lymphoma, is in remission and alive. In the next 40 years transplants of blood-derived progenitor cells have become the most common graft for auto- and allotransplants. The rapid hematopoietic recovery after blood cell-derived grafts is associated with fewer short-term complications and better outcomes in many settings compared with bone marrow-derived grafts but may be associated with more graft-versus-host disease (GvHD) after allotransplants. Using blood-derived grafts also reduced costs, enabled the development of cell-based immune therapy and in vitro manipulation of blood-derived cells for gene and chimeric antigen receptor (CAR)-T-cell therapies. https://cassyni-user-files-prod.s3.amazonaws.com/QFG7xJs3qu6kDCBBKFiHZQ https://cassyni.com/slides/outline/LhUDZ1sPkUYnAXMTzrzYDK https://cassyni.com/events/LhUDZ1sPkUYnAXMTzrzYDK/abstract https://cassyni-user-files-prod.s3.amazonaws.com/LmKroD6vyEqnkrQ8fCARcz https://cassyni.com/events/LhUDZ1sPkUYnAXMTzrzYDK?videoPreview=1 Heatwave winners and losers: cryptic coral holobionts differ in thermal tolerancenohttps://cassyni.com/events/LhUDZ1sPkUYnAXMTzrzYDK?videoPreview=12026-05-14T03:00:00+00:001186.8Royal Society PublishingExtreme climatic events are increasingly reshaping ecosystems as organisms vary greatly in their ability to survive these disturbances. In our new study, we investigated thermal stress responses in the Stylophora pistillata coral species complex during a heatwave at Heron Island Reef, on the Great Barrier Reef. Survival of coral fragments under the same thermal stress closely matched survival of their source colonies on the reef, indicating that biological differences, rather than local environmental conditions, largely drive persistence. Interestingly, we found significant variation in bleaching severity and survival among three sympatric cryptic species and their host-specific symbionts. These findings highlight how cryptic biological diversity can shape outcomes after a heatwave and advance our understanding of coral vulnerability in a rapidly warming world.https://cassyni-user-files-prod.s3.amazonaws.com/LmKroD6vyEqnkrQ8fCARcz https://cassyni.com/slides/outline/QA34zRuxE3MC1v7erCCff3 https://cassyni.com/events/QA34zRuxE3MC1v7erCCff3/abstract https://cassyni-user-files-prod.s3.amazonaws.com/3P4UKDSNrmMQnrjUgktZwU https://cassyni.com/events/QA34zRuxE3MC1v7erCCff3?videoPreview=1 Breastfeeding and early Bifidobacterium-driven microbial colonization shape the infant gut resistomenohttps://cassyni.com/events/QA34zRuxE3MC1v7erCCff3?videoPreview=12026-06-02T02:00:00+00:00685.32Microbiome Virtual International ForumThe first year of life is a critical period for the acquisition and establishment of the infant gut resistome, as microbiome development is directly influenced by perinatal factors to which the neonate is exposed, such as feeding type or antibiotic use. This study aims to analyze the evolution of the infant resistome during the first year of life and to provide further insight into how breastfeeding may modulate the acquisition of antimicrobial resistance. A longitudinal metagenomic study of the gut microbiome was conducted 265 gut longitudinal metagenomes from 66 mother-infant pairs from the MAMI cohort (at 7 days, 1, 6, and 12 months of age). Detailed clinical data from mother–infant pairs were also collected, including mode of delivery, antibiotic use during delivery, and feeding practices. The microbial profile obtained after high-throughput sequencing (Illumina) was analyzed using the MetaPhlAn tool, while the resistome was characterized using ResFinder. Statistical analyses were performed using R software. During the first year of life, the diversity of antibiotic resistance genes (ARGs) increased, with tetracycline and aminoglycoside resistance genes being the most abundant. The composition of the infant microbiome was classified into two groups based on the abundance of the genus Bifidobacterium: high abundance (High-Bifidobacterium, HB) and low abundance (Low-Bifidobacterium, LB). Infants in the LB group exhibited higher levels of ARG abundance, mainly associated with species such as Escherichia coli and Klebsiella pneumoniae, which were the primary carriers of resistance. Exclusive breastfeeding during the first month of life mitigated the effects of cesarean delivery on the infant resistome, reducing ARG load. Exclusive breastfeeding during the first month of life is essential in shaping the infant resistome. By promoting a microbiome enriched in Bifidobacterium, breastfeeding may help suppress ARG-carrying taxa, reducing the risk of resistance dissemination. Our findings underscore the importance of breastfeeding as a natural intervention to shape the infant microbiome and resistome. Supporting breastfeeding through public health policies could help limit the spread of antimicrobial resistance in early life.https://cassyni-user-files-prod.s3.amazonaws.com/3P4UKDSNrmMQnrjUgktZwU https://cassyni.com/slides/outline/Emib7ScytLpxqPQjrAcq4h https://cassyni.com/events/Emib7ScytLpxqPQjrAcq4h/abstract https://cassyni-user-files-prod.s3.amazonaws.com/QEg6VfosZ7cYF6NhbhBhvn https://cassyni.com/events/Emib7ScytLpxqPQjrAcq4h?videoPreview=1 T73T75 phosphorylation of B56ᴾᵃʳ¹ uncovers PP2A-B56 as a key regulator of mitotic entrynohttps://cassyni.com/events/Emib7ScytLpxqPQjrAcq4h?videoPreview=12026-07-23T15:00:00+00:002136.4Royal Society PublishingMitosis is triggered when the rising activity of CDK1-Cyclin B, amplified by the CDK1/Cdc25/Wee1 feedback loop, overcomes inhibitory signalling from Wee1 and counteracting phosphatases. CDK-opposing phosphatases PP1, PP2A-B55 and PP2A-B56 are regulators of mitosis. A screen for differentially phosphorylated sites in a *∆PP1ᵈⁱˢ²* genetic background in *Schizosaccharomyces pombe* identified phosphorylation of T73 or T75 in the regulatory B56ᴾᵃʳ¹ subunit. The B56ᴾᵃʳ¹.T73T75 phosphorylation is directly mediated by CDK1-Cyclin B, and a phospho-mimetic mutation increased while non-phosphorylatable reduced PP2A-B56ᴾᵃʳ¹ phosphatase activity. Blocking B56ᴾᵃʳ¹.T73T75 phosphorylation reduced cell length in unperturbed divisions from 14 to 12 µm, without causing pleiotropic defects. Therefore, blocking phosphorylation at T73T75 alone prematurely unlocked amplification of the CDK1/Cdc25/Wee1 feedback loop, advancing cells into mitosis. Signalling from T73T75 reveals for the first time that timely mitotic commitment in unperturbed cycles is mediated by PP2A-B56. https://cassyni-user-files-prod.s3.amazonaws.com/QEg6VfosZ7cYF6NhbhBhvn https://cassyni.com/events/GGCERTMPra64d7wrqjPUU5/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Ra7ZD6tyy4igfk2kHH1rGN https://cassyni.com/slides/outline/6Ne56ZbHcqZUhaKQLEuq57 https://cassyni.com/events/6Ne56ZbHcqZUhaKQLEuq57/abstract https://cassyni-user-files-prod.s3.amazonaws.com/PFV4UgY9ywRNFdNf2HGmR8 https://cassyni.com/events/6Ne56ZbHcqZUhaKQLEuq57?videoPreview=1 KeAi Talk: ISWCR Series IV_PhD. Manuel La Licatanohttps://cassyni.com/events/6Ne56ZbHcqZUhaKQLEuq57?videoPreview=12026-04-21T12:00:00+00:00954.56NoneNature-based Solutions and Modelling Innovations for Sustainable Soil and Water Management under Climate Extremes [International Soil and Water Conservation Research (ISWCR)](https://www.keaipublishing.com/en/journals/international-soil-and-water-conservation-research/), the official journal of the [World Association of Soil and Water Conservation (WASWAC)](http://www.waswac.org.cn), is a multidisciplinary journal for soil and water conservation research, practice, policy, and perspectives. This journal aims to disseminate new knowledge and promote the practice of soil and water conservation. https://cassyni-user-files-prod.s3.amazonaws.com/PFV4UgY9ywRNFdNf2HGmR8 https://cassyni.com/events/WbDjgKEhojZT9XweFCJbcq/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Xp6HSceFH1yXYvNczZjNhk