https://cassyni.com/events/2STeqkxzcAUrdbHZCvjWVK/abstract https://cassyni-user-files-prod.s3.amazonaws.com/JsAQ8KX3eZ75Fxc5f5XvTQ https://cassyni.com/events/QfVjMNWBLxmMxshKP4sL6q/seminar/qa https://cassyni.com/slides/outline/QfVjMNWBLxmMxshKP4sL6q https://cassyni.com/events/QfVjMNWBLxmMxshKP4sL6q/abstract https://cassyni-user-files-prod.s3.amazonaws.com/6Kw8Va4enHC3hWfEXvFGXx https://cassyni.com/events/QfVjMNWBLxmMxshKP4sL6q?videoPreview=1 Engaging your Readers and Authorsnohttps://cassyni.com/events/QfVjMNWBLxmMxshKP4sL6q?videoPreview=12023-03-20T16:30:00+00:002583.6Topics at the heart of our communityHow factual is the assumption that publishing less always results in higher impact for journals? Discover how a high volume of content in specific sub-disciplines can lead to an increase in high quality submissions, and why quantity and quality are complementary strategies for journal development.https://cassyni-user-files-prod.s3.amazonaws.com/6Kw8Va4enHC3hWfEXvFGXx https://cassyni.com/events/HkStpRxibuwg2JVvd1Nfpy/seminar/qa https://cassyni.com/slides/outline/HkStpRxibuwg2JVvd1Nfpy https://cassyni.com/events/HkStpRxibuwg2JVvd1Nfpy/abstract https://cassyni-user-files-prod.s3.amazonaws.com/WU6MhwooWuMfAnsbTv3AEA https://cassyni.com/events/HkStpRxibuwg2JVvd1Nfpy?videoPreview=1 Revising the Elenchus via Belief Revisionnohttps://cassyni.com/events/HkStpRxibuwg2JVvd1Nfpy?videoPreview=12023-05-10T14:00:00+00:003985.8Logica UniversalisVlastos’ famous characterization of the Socratic elenchus focuses on two main aspects of this method: its epistemic roots and its dialogical nature. Our aim is to lay the groundwork to formally capture this characterization. To do so, first, we outline an epistemic framework in which the elenchus can be inscribed. More precisely, we focus our analysis on the passage from unconscious ignorance to conscious (or Socratic) ignorance and provide new insights about the epistemic outcome of an elenctic argument. Secondly, from a logical perspective, we consider the elenchus as a dynamic exchange allowing Socrates’ respondents to revise their beliefs, on pain of inconsistency. By stressing this point, we represent this method as a process of belief revision in dynamic epistemic logic and provide a new logical solution to what Vlastos called the problem of the elenchus.https://cassyni-user-files-prod.s3.amazonaws.com/WU6MhwooWuMfAnsbTv3AEA https://cassyni.com/slides/outline/TdQyk6uDP51zspVx8a92xu https://cassyni.com/events/TdQyk6uDP51zspVx8a92xu/abstract https://cassyni-user-files-prod.s3.amazonaws.com/3khwDJD29U966C7SkdCqkA https://cassyni.com/events/TdQyk6uDP51zspVx8a92xu?videoPreview=1 Session 3nohttps://cassyni.com/events/TdQyk6uDP51zspVx8a92xu?videoPreview=12023-07-03T01:00:00+00:006268.72New Phytologist Foundation Nitrogen is an essential macronutrient that is absorbed by roots and stored in leaves, mainly as ribulose-1,5-bisphosphate carboxylase/oxygenase. To adapt to nitrogen deficiency (-N), leaf senescence facilitates nitrogen redistribution. As the key transcription factor of Arabidopsis thaliana senescence, ORESARA1 (ORE1) is required for nitrogen deficiency (-N) induced senescence. Here, two essential observations were made. First, we found that Arabidopsis MED19a associates with ORE1 to activate -N senescence-responsive genes. Disordered MED19a forms inducible nuclear condensates under -N that is regulated by decreasing MED19a lysine acetylation. MED19a carboxyl terminus (cMED19a) harbors a mixed-charged intrinsically disordered region (MC-IDR) required for ORE1 interaction and liquid-liquid phase separation (LLPS). Second, -N signals, which are initially perceived by roots, are subsequently propagated to shoots to trigger senescence; however, the mechanism of -N signal propagation remains underexplored. We found that ELF18-INDUCED LONG NONCODING RNA 1 (ELENA1) is -N inducible and attenuates -N induced senescence in Arabidopsis. Analysis of plants expressing ELENA1 promoter β-glucuronidase fusion gene showed that ELENA1 is transcribed specifically in roots under -N. Reciprocal grafting of WT and elena1 demonstrated that ELENA1 functions systemically. ELENA1 dissociates the MEDIATOR SUBUNIT 19a-ORESARA1 transcriptional complex thereby calibrating senescence progression. Our observations establish the systemic regulation of leaf senescence by a root-derived long noncoding RNA under -N in Arabidopsis. Rice (Oryza sativa) is an important staple crop to address the Hidden Hunger problem. The brown rice is known to be nutritious due to elevated mineral composition. The genetics underlying brown rice ionome remains largely unexplored. Hence, we conducted a comprehensive study to dissect the genetic architecture of the brown rice ionome. We used genome-wide association studies (GWAS), gene set analysis, and targeted association analysis for 12 micronutrients in the brown rice grains. A diverse panel of 300 resequenced indica accessions, with more than 1.02 million single nucleotide polymorphisms, was used. We identified 109 candidate genes with 5-20% phenotypic variation explained (PVE) for the 12 micronutrients with epistatic interactions for multiple micronutrients. Pooling all candidate genes per micronutrient exhibited PVE values ranging from 11% to almost 40%. The key donor lines with larger concentrations for most of the micronutrients possessed superior alleles, which were absent in the breeding lines. Through gene regulatory networks we identified enriched functional pathways for central regulators that were detected as key candidate genes through GWAS. This study provided important insights on the ionome variations in rice, on the genetic basis of the genome-ionome relationships, and on the molecular mechanisms underlying micronutrient signatures. Autophagy, an intracellular degradation and recycling process, is gaining attention as a stress-coping mechanism in eukaryotes. It is induced by many nutrient-deprivation conditions and biotic and abiotic stresses in plants. Over-expression of autophagy-related genes in several plant species increased plant size, yield, and stress resistance. Yet, regulatory restrictions on transgenic plants hinder the direct modulation of autophagy in crops, and the constitutive induction of autophagy might prove unuseful in all environmental conditions. Thus, other means of modulating autophagy are needed. Previous works from plant and animal systems demonstrated the possible role of regulatory sugars in autophagy stimulation. Our research aims to find a natural sugar that activates autophagy in plants by spraying. We identified the trisaccharide raffinose as an autophagy inducer in plants. We demonstrate that raffinose treatment increased the performance of several crop species, both monocot and eudicot, and seed yield in an autophagy-dependent mannerin growth room and field conditions. The data gained in this project will help elucidate how regulatory sugars influence autophagy in plants. Moreover, it will serve as the basis for developing raffinose, and possibly other autophagy regulators, as agrochemicals to improve crop plant growth and yield. Many species of Myrtaceae, an economically and ecologically significant plant family in Australia are threatened by myrtle rust infection caused by Austropuccinia psidii. We conducted a comprehensive analysis of R-genes that encode for nucleotide-binding sites (NBS) using long-read sequences of 28 species to investigate the genetic basis of disease resistance. We predicted 1.04 million gene models encoding 47.7k NBS and leucine-rich repeat (LRR) domains. We detected 260 unique domains with diverse frequencies of integration into NBS-LRR genes. A single Jacalin domain accounted for 43.1% of the total integration frequency. Tol/interleukin-1 (TIR), which encodes for NBS but lacks LRR, was highly expanded with 1-10 copies of Jacalin (J) in its C-terminal (TNJ). TNJ formed a monophyletic clade nested within the TN that encodes for LRR (TNL) clades. Important nucleotide-binding motifs and functional amino-acid residues were conserved in the TNJ. Similar to what has been observed in LRR domains elsewhere, hyper-variable and positively selected sites were found clustered in the Jacalin region of TNJ. Thus, Jacalin may be a functional analogue of LRR in terms of pathogen molecule recognition. Our findings reveal that different tree families could evolve with different pathogen recognition specificity, and clade-specific R-gene organization might contribute to specific niche adaptation in distinct plant families. The response of plants to cross-stress is poorly understood and is reported to be non-additive with respect to its single stress response. Plants are expected to be exposed to multiple stress conditions in higher frequency and of higher intensity amidst the outlook of climate change. In this study, we explored the response of Marchantia polymorpha, an early diverging land plant to 7 abiotic stresses (cold, darkness, heat, light, mannitol, nitrogen deficiency and salt) and 19 pairwise combinations through the lens of differential expression, inferred regulatory relationships, conservation of regulation with respect to Arabidopsis and the relationship between gene expression values (log2 fold-change) during single and cross-stress using linear regression. The observation of dominance, non-additivity and novel responses in cross-stress was congruent with what has been described in the literature. Regulatory relationships inferred were often stress-specific and Arabidopsis TF orthologs were responsive in a wider range of stresses in contrast to stress-specific Marchantia TFs. Remarkably, we discovered that gene expression values of cross-stress datasets could be accurately predicted with the values of single stress through linear regression, and the predictive power of single stress corresponded to its dominance in relation to other stresses. This talk will not be available to watch on demand. The auxin research field is highly advanced with functional models of cellular dynamics of IAA impacting nearly all aspects of plant physiology and development. However, these are largely based on either destructive, lower-resolution direct measurements (e.g. GC-MS) or indirect measurements in vivo (e.g. DR5, DII-Venus). Hence, our goal is to engineer direct biosensors for auxin based on FRET (Förster Resonance Energy Transfer), analogous to other ratiometric biosensors for plant hormones. We engineered IAA Genetically-encoded Optical FRET biosensors (IAAGO1/IAAGO2), to track auxin dynamics directly, in real-time and with subcellular resolution in a minimally invasive manner. IAAGO1 is derived from a prokaryotic biosensor protein and had IAA affinity of ~1.5µM, that we later optimised to a present version with higher affinity (KdIAA ~400nM). IAAGO1 responds to auxin with high signal-to-noise ratio in E. coli, yeast, in planta and in vitro. IAAGO2 is derived from an initial biosensor protein that we engineered for very high affinity (KdIAA ~10nM) for auxin, comparable to auxin physiological range. Already IAAGO2s have revealed novel auxin dynamics in the cell nuclei of growing Arabidopsis organs and ongoing optimisation efforts will establish IAAGO2 utility for illuminating the many biological phenomena where cellular auxin dynamics are thought to be determinative.https://cassyni-user-files-prod.s3.amazonaws.com/3khwDJD29U966C7SkdCqkA https://cassyni.com/events/3ReNUcCVsdt6i8k7CnqjYZ/seminar/qa https://cassyni.com/slides/outline/3ReNUcCVsdt6i8k7CnqjYZ https://cassyni.com/events/3ReNUcCVsdt6i8k7CnqjYZ/abstract https://cassyni-user-files-prod.s3.amazonaws.com/VvHBF9RnbZGihXnpUiqaHk https://cassyni.com/events/3ReNUcCVsdt6i8k7CnqjYZ?videoPreview=1 Session 1: The DEFINE Study (for Regulators, Funders, Journal Editors and Ethics Committee Members)nohttps://cassyni.com/events/3ReNUcCVsdt6i8k7CnqjYZ?videoPreview=12023-07-13T12:30:00+00:001499.52Institute for Cancer ResearchNo abstracthttps://cassyni-user-files-prod.s3.amazonaws.com/VvHBF9RnbZGihXnpUiqaHk https://cassyni.com/events/U7yiSu15cSnxnbU5hWPxtu/seminar/qa https://cassyni.com/slides/outline/U7yiSu15cSnxnbU5hWPxtu https://cassyni.com/events/U7yiSu15cSnxnbU5hWPxtu/abstract https://cassyni-user-files-prod.s3.amazonaws.com/aCmNs3urPUvXYJztsueM4 https://cassyni.com/events/U7yiSu15cSnxnbU5hWPxtu?videoPreview=1 Teacher Strategies in Implementing English Medium Instructionnohttps://cassyni.com/events/U7yiSu15cSnxnbU5hWPxtu?videoPreview=12023-03-17T03:10:00+00:003173.32Linguistics and Applied Language StudiesThe expanding role of English as the lingua franca of higher education worldwide has created a requirement for many university instructors to teach their subjects in English rather than in their usual language of instruction. Consequently, in many situations university teachers who were confident in their ability to provide quality teaching in their first language find themselves having to rethink their teaching approaches in order to teach their courses in English In implementing EMI, a common assumption has been that the primary issue affecting successful EMI is the English proficiency level of the EMI instructor. In this presentation the role that English plays in developing disciplinary literacy and competence is explored. A review of EMI teachers’ accounts of their instructional practices is used to to demonstrate the challenges content teachers face in teaching their academic subjects in English and ways in which they adapt their teaching in order to prepare for and manage EMI instruction. https://cassyni-user-files-prod.s3.amazonaws.com/aCmNs3urPUvXYJztsueM4 https://cassyni.com/slides/outline/6t6jTWBWjkyeeqUupxBpk5 https://cassyni.com/events/6t6jTWBWjkyeeqUupxBpk5/abstract https://cassyni-user-files-prod.s3.amazonaws.com/2gfNjQFqqfjBxyzDxSTZMQ https://cassyni.com/events/6t6jTWBWjkyeeqUupxBpk5?videoPreview=1 Revisiting the Relationship Between Receptive Vocabulary Knowledge and Receptive Language Proficiency – a Multi-Group SEM Approachnohttps://cassyni.com/events/6t6jTWBWjkyeeqUupxBpk5?videoPreview=12023-05-26T04:10:00+00:002521.16Linguistics and Applied Language StudiesIn recent years, applied linguists have paid more attention to the contributory roles of vocabulary knowledge in language subskills. However, little evidence has been collected to shed light upon the cross-modality relationship between the two modalities of receptive word knowledge, namely phonological and orthographic vocabulary, and receptive language skills, namely reading and listening comprehension. Moreover, the majority of studies conducted on the topic only examined the bivariate correlations between the modalities and did not take the shared variance of the constructs into account, making their findings superficial. The present study analyzed a dataset which reported the performance of 234 students on two validated tests of receptive phonological and orthographic vocabulary knowledge and two standardized tests of listening and reading proficiency. Multi-group, covariance-based structural equation modeling (CB-SEM) was applied. Results from the analyses showed that both aural and orthographic knowledge of words were of equal importance to learners’ receptive vocabulary knowledge. While whole-group results revealed that vocabulary knowledge contributed equally to learners’ reading and listening proficiency, multi-group analyses indicated noticeable differences in the contributory role of receptive word knowledge in comprehension between learners of different vocabulary size groups. The role of vocabulary size in the relationship between vocabulary knowledge and comprehension as well as practical implications for vocabulary assessment are discussed.https://cassyni-user-files-prod.s3.amazonaws.com/2gfNjQFqqfjBxyzDxSTZMQ https://cassyni.com/slides/outline/NCFi7xGZ9fzsbwDkqNxhNu https://cassyni.com/events/NCFi7xGZ9fzsbwDkqNxhNu/abstract https://cassyni-user-files-prod.s3.amazonaws.com/GAfC9Dzi1voGUH2t1UgsGi https://cassyni.com/events/NCFi7xGZ9fzsbwDkqNxhNu?videoPreview=1 GenASiS Basics: Object-oriented utilitarian functionality for large-scale physics simulationsnohttps://cassyni.com/events/NCFi7xGZ9fzsbwDkqNxhNu?videoPreview=12023-04-18T15:00:00+00:002907.24Computer Physics CommunicationsGenASiS Basics provides modern Fortran classes furnishing extensible object-oriented utilitarian functionality for large-scale physics simulations on distributed memory supercomputers. This functionality includes physical units and constants; display to the screen or standard output device; message passing; I/O to disk; and runtime parameter management and usage statistics. The latest version of this release includes major additions to its functionality: infrastructure facilitating the offloading of computational kernels to devices such as GPUs and the facilitation of direct communication between GPUs. In this talk, I will start with the overarching motivation of this work, which is to harness the computational power of GPUs to perform astrophysical simulations. Then I will describe the high-level overview of GenASiS and the functionality afforded by GenASiS Basics. I will also describe how we use OpenMP in GenASiS Basics to create an infrastructure to seamlessly manage data movement and offload computational kernels to GPUs. I will also describe an example fluid dynamic application included in GenASiS Basics showing significant speedups when using GPUs via the above-mentioned infrastructure. Finally and most importantly, I will show how one can leverage the functionality provided by GenASiS Basics to program their physics application to run on clusters and supercomputers.https://cassyni-user-files-prod.s3.amazonaws.com/GAfC9Dzi1voGUH2t1UgsGi https://cassyni.com/slides/outline/HFmff7oJm6TrCqWQpuFhem https://cassyni.com/events/HFmff7oJm6TrCqWQpuFhem/abstract https://cassyni-user-files-prod.s3.amazonaws.com/RhHaVuSgPtSsRaPaURCAXx https://cassyni.com/events/HFmff7oJm6TrCqWQpuFhem?videoPreview=1 Sparse Nonlinear Dynamics Models with SINDy, Part 3: Effective Coordinates for Parsimonious Modelsnohttps://cassyni.com/events/HFmff7oJm6TrCqWQpuFhem?videoPreview=12021-09-24T12:00:00+00:001179.52Brunton LabThis video discusses how to choose good coordinates for the Sparse Identification of Nonlinear Dynamics (SINDy) algorithm. Specifically, we consider high dimensional and low dimensional measurements of a nonlinear dynamical system. For high dimensional systems, we recommend either the singular value decomposition (SVD), also known as principal component analysis (PCA), or a deep autoencoder neural network. For low dimensional data, we recommend time delay coordinates, which are connected to Koopman theory. SLB acknowledges support from the National Science Foundation AI Institute in Dynamic Systems (grant number 2112085).https://cassyni-user-files-prod.s3.amazonaws.com/RhHaVuSgPtSsRaPaURCAXx https://cassyni.com/slides/outline/Se69Y76H6nz84ayYk2jGXP https://cassyni.com/events/Se69Y76H6nz84ayYk2jGXP/abstract https://cassyni-user-files-prod.s3.amazonaws.com/FU4hBkALezDa2GCUajYjnn https://cassyni.com/events/Se69Y76H6nz84ayYk2jGXP?videoPreview=1 Simultaneous Information Releases and Capital Market Feedback: Evidence from Patent Tuesdaysnohttps://cassyni.com/events/Se69Y76H6nz84ayYk2jGXP?videoPreview=12023-11-30T22:00:00+00:003288.72SACLWe examine whether the simultaneous release of information affects managers’ ability to gather decision-relevant information from market prices. Using the plausibly exogenous timing of patent grant disclosures by the United States Patent and Trademark Office as a source of variation in the simultaneous release of value-relevant information, we show that the market’s response to patent grants is more informative for managerial decisions if the firm receives fewer patent grants on the same day. This effect is more pronounced for patents that relate to relatively more exploratory innovative strategies for which feedback is arguably more important. Firms with more distinct information releases also produce more valuable and higher quality innovations in the future. Taken together, our results suggest that bundling the release of multiple pieces of information at once potentially impedes managers’ ability to benefit from the market’s feedback. Paper via [Tresorit link](https://web.tresorit.com/l/KFY6u#WKX2_biXsWlxal2hRYD4ag).https://cassyni-user-files-prod.s3.amazonaws.com/FU4hBkALezDa2GCUajYjnn https://cassyni.com/events/2SKYGcPZbMrDtuDhpFRy73/seminar/qa https://cassyni.com/slides/outline/2SKYGcPZbMrDtuDhpFRy73 https://cassyni.com/events/2SKYGcPZbMrDtuDhpFRy73/abstract https://cassyni-user-files-prod.s3.amazonaws.com/EtDJiaGzXnr6dMuWsUoA9k https://cassyni.com/slides/outline/NgvwHGRxzVUhRQDGdV5fZ7 https://cassyni.com/events/NgvwHGRxzVUhRQDGdV5fZ7/abstract https://cassyni-user-files-prod.s3.amazonaws.com/KkcTxnQ4hb7eBaXo73GTYz https://cassyni.com/events/NgvwHGRxzVUhRQDGdV5fZ7?videoPreview=1 Mapping the landscapes of cancernohttps://cassyni.com/events/NgvwHGRxzVUhRQDGdV5fZ7?videoPreview=12021-04-20T09:00:00+00:005469.92Journal of Biological PhysicsCancer drug resistance or metastasis can be visualized as cells exploring fitness landscapes. I will illustrate the utility of fitness landscapes in understanding oncogenic processes and provide examples of how we can infer such landscapes experimentally with the help of noise-controlling synthetic gene circuits in human cancer cells.https://cassyni-user-files-prod.s3.amazonaws.com/KkcTxnQ4hb7eBaXo73GTYz https://cassyni.com/slides/outline/RAAxWgfbBnFWWt2PatEQEy https://cassyni.com/events/RAAxWgfbBnFWWt2PatEQEy/abstract https://cassyni-user-files-prod.s3.amazonaws.com/SgRLT25bvyJofVDngngDLS https://cassyni.com/events/RAAxWgfbBnFWWt2PatEQEy?videoPreview=1 A comparison of the effects of resistant starch types on glycemic response in individuals with type 2 diabetes or prediabetes: A systematic review and meta-analysisnohttps://cassyni.com/events/RAAxWgfbBnFWWt2PatEQEy?videoPreview=12023-07-31T12:00:00+00:001771.32Imperial College London Early Career Researcher Institute#### Background Type 2 diabetes (T2D) diagnoses are predicted to reach 643 million by 2030, increasing incidences of cardiovascular disease and other comorbidities. Rapidly digestible starch elevates postprandial glycemia and impinges glycemic homeostasis, elevating the risk of developing T2D. Starch can escape digestion by endogenous enzymes in the small intestine when protected by intact plant cell walls (resistant starch type 1), when there is a high concentration of amylose (resistant starch type 2) and when the molecule undergoes retrogradation (resistant starch type 3) or chemical modification (resistant starch type 4). Dietary interventions using resistant starch may improve glucose metabolism and insulin sensitivity. However, few studies have explored the differential effects of resistant starch type. This systematic review and meta-analysis aims to compare the effects of the resistant starch from intact plant cell structures (resistant starch type 1) and resistant starch from modified starch molecules (resistant starch types 2–5) on fasting and postprandial glycemia in subjects with T2D and prediabetes. #### Methods Databases (PubMed, SCOPUS, Ovid MEDLINE, Cochrane, and Web of Science) were systematically searched for randomized controlled trials. Standard mean difference (SMD) with 95% confidence intervals (CI) were determined using random-effects models. Sub-group analyses were conducted between subjects with T2D versus prediabetes and types of resistant starch. #### Results The search identified 36 randomized controlled trials (n = 982), 31 of which could be included in the meta-analysis. Resistant starch type 1 and type 2 lowered acute postprandial blood glucose [SMD (95% CI) = -0.54 (–1.0, –0.07)] and [–0.96 (–1.61, –0.31)]. Resistant starch type 2 improved acute postprandial insulin response [–0.71 (–1.31, –0.11)]. In chronic studies, resistant starch type 1 and 2 lowered postprandial glucose [–0.38 (–0.73, –0.02), –0.29 (–0.53, –0.04), respectively] and resistant starch type 2 intake improved fasting glucose [–0.39 (–0.66, –0.13)] and insulin [–0.40 (–0.60, –0.21)]. #### Conclusion Resistant starch types 1 and 2 may influence glucose homeostasis via discrete mechanisms, as they appear to influence glycemia differently. Further research into resistant starch types 3, 4, and 5 is required to elucidate their effect on glucose metabolism. The addition of resistant starch as a dietary intervention for those with T2D or prediabetes may prevent further deterioration of glycemic control.https://cassyni-user-files-prod.s3.amazonaws.com/SgRLT25bvyJofVDngngDLS https://cassyni.com/events/8N8QwSfkGDR87ETTDGYjGh/abstract https://cassyni-user-files-prod.s3.amazonaws.com/f9EbXvgYnS19fNvipW7z6 https://cassyni.com/events/2vzmRvYySBL3iNDDcMYwHF/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Kavf6EJmsFrKtQESRNALx6 https://cassyni.com/slides/outline/DoG4SxnX6FWXEe3FDtndE5 https://cassyni.com/events/DoG4SxnX6FWXEe3FDtndE5/abstract https://cassyni-user-files-prod.s3.amazonaws.com/H6DFTkgBzq5jEs5UW974Sz https://cassyni.com/events/DoG4SxnX6FWXEe3FDtndE5?videoPreview=1 Session 4nohttps://cassyni.com/events/DoG4SxnX6FWXEe3FDtndE5?videoPreview=12023-07-03T03:15:00+00:002535.24New Phytologist Foundation In plants, the root system plays many important roles, including anchorage, water, and mineral uptake, and responding to environmental signals. The mechanisms underlying root system development are complex and involve many phytohormones of which auxin is the most important one. However, the role of plant stress hormone Jasmonic acid in root development remained elusive. Here, we report that Jasmonic acid promotes crown root development in rice by regulating OsGER4, a Germin-like protein. This gene was discovered by a Genome-Wide Association Study while observing the increase of crown root under Jasmonic acid-stimulated stress. OsGER4 was confirmed to be a hormone-responsive gene involved in various stress responses and its expression coincided with the auxin distribution pattern for lateral root initiation and crown root emergence. Further studies revealed that OsGER4 is targeted in plasmodesmata, suggesting how OsGER4 could be involved in regulating plasmodesmata permeability to regulate the auxin flow as a part of stress responses that results in changes in root development. Overall, the study provides significant novel insights on auxin homeostasis via uncharted roots through plasmodesmata with the involvement of OsGER4 during root formation in rice under perturbation conditions. Root developmental plasticity is critical for plants to adapt to changing soil environment, where nutrients and abiotic stress factors are distributed heterogeneously. How plant roots sense and avoid heterogeneous abiotic stress in soil remains unclear. Here, we show that, in response to asymmetric stress of heavy metals (Cd, Cu or Pb) and salt (NaCl), rice roots rapidly proliferate lateral root branching in the stress-free area, thereby remodeling root architecture to avoid localized stress. Imaging and quantitative analyses of reactive oxygen species (ROS) show that asymmetric stress induces ROS burst in the tips of the exposed roots, simultaneously triggering rapid systemic ROS signaling to the unexposed roots, which is prerequisite to stress-induced lateral root branching. We identify two respiratory burst oxidase homologs, OsRBOHA and OsRBOHI, as key players for ROS generation and systemic signaling in response to asymmetric stress. Auxin signaling and cell wall remodeling act downstream of the systemic ROS signaling to promote lateral root development. Our study reveals a RBOH-ROS-auxin signaling cascade that enables rice roots to avoid localized stress of heavy metals and salt and provides new insight into root system plasticity in heterogenous soil.https://cassyni-user-files-prod.s3.amazonaws.com/H6DFTkgBzq5jEs5UW974Sz https://cassyni.com/slides/outline/ALiq8BFr23dtCwjgaEQfhF https://cassyni.com/events/ALiq8BFr23dtCwjgaEQfhF/abstract https://cassyni-user-files-prod.s3.amazonaws.com/WK9wf64Mv2P231wuNRfcEr https://cassyni.com/events/ALiq8BFr23dtCwjgaEQfhF?videoPreview=1 Postoperative course of cerebrospinal fluid diversion in the setting of leptomeningeal disease: a systematic review, meta-analysis, and meta-regression with an illustrative casenohttps://cassyni.com/events/ALiq8BFr23dtCwjgaEQfhF?videoPreview=12023-07-10T20:00:00+00:001450.4Journal of Neuro-OncologyJoin Dr. Randy D'Amico and Dr. Jason Sheehan of the Journal of Neuro-Oncology for a discussion with Dr. Victor Lu from the University of Miami Miller School of Medicine about his latest journal article on the postoperative course of cerebrospinal fluid diversion in the setting of leptomeningeal disease.https://cassyni-user-files-prod.s3.amazonaws.com/WK9wf64Mv2P231wuNRfcEr https://cassyni.com/slides/outline/CoxrMbVUDLQNZtDF7vKJRB https://cassyni.com/events/CoxrMbVUDLQNZtDF7vKJRB/abstract https://cassyni-user-files-prod.s3.amazonaws.com/7TDaP4sCvLHNgPP95seemC https://cassyni.com/events/CoxrMbVUDLQNZtDF7vKJRB?videoPreview=1 Co-orbital dynamicsnohttps://cassyni.com/events/CoxrMbVUDLQNZtDF7vKJRB?videoPreview=12022-09-07T16:45:00+00:00942.88Celestial Mechanics and Dynamical AstronomyCo-orbital planets (in a 1:1 mean motion resonance) can be formed within a Laplace resonance chain. Here, we develop a secular model to study the dynamics of the resonance chain $p:p:p+1$, where the co-orbital pair is in a first-order mean motion resonance with the outermost third planet. Our model takes into account tidal dissipation through the use of a Hamiltonian version of the constant time-lag model, which extends the Hamiltonian formalism of the point-mass case. We show the existence of several families of equilibria, and how these equilibria extend to the complete system. In one family, which we call the $\textit{main branch}$, a secular resonance between the libration frequency of the co-orbitals and the precession frequency of the pericentres has unexpected dynamical consequences when tidal dissipation is added. We report the existence of two distinct mechanisms that make co-orbital planets much more stable within the $p:p:p+1$ resonance chain rather than outside it. The first one is due to negative real parts of the eigenvalues of the linearized system with tides, in the region of the secular resonance mentioned above. The second one comes from non-linear contributions of the vector field and it is due to eccentricity damping.https://cassyni-user-files-prod.s3.amazonaws.com/7TDaP4sCvLHNgPP95seemC https://cassyni.com/slides/outline/PgFmVGEuGmWaEwKWys6mDo https://cassyni.com/events/PgFmVGEuGmWaEwKWys6mDo/abstract https://cassyni-user-files-prod.s3.amazonaws.com/NVA4yw3rvHb9Po41fovev2 https://cassyni.com/events/PgFmVGEuGmWaEwKWys6mDo?videoPreview=1 Pathways towards community-based, transparent, and systematic quality control of research objectsnohttps://cassyni.com/events/PgFmVGEuGmWaEwKWys6mDo?videoPreview=12022-09-19T15:00:00+00:002271.24DeSci FoundationNo abstracthttps://cassyni-user-files-prod.s3.amazonaws.com/NVA4yw3rvHb9Po41fovev2 https://cassyni.com/slides/outline/X5yqBWwmrdpQjWqywjxVdo https://cassyni.com/events/X5yqBWwmrdpQjWqywjxVdo/abstract https://cassyni-user-files-prod.s3.amazonaws.com/JsVs8YysqQj38uhQzbPa5c https://cassyni.com/events/X5yqBWwmrdpQjWqywjxVdo?videoPreview=1 Pets vs Cattle:  Heterogeneous Systems in the 21st Centurynohttps://cassyni.com/events/X5yqBWwmrdpQjWqywjxVdo?videoPreview=12023-09-11T13:30:00+00:001699.48HiPEDS CentreDecades ago computers were pets. They sat on our desktops, had names and we cared for them as individuals. More recently, in addition to pets, computers have become cattle. They are out in the field, are identified by numbers, and if one dies it is replaced without associated mourning. The same transition is happening to hardware accelerators, including Graphics Processing Units (GPUs) and Field Programmable Gate Arrays (FPGAs), which can now be considered cattle in cloud computers. A new model for cloud computing is disaggregation, which allows users to flexibly acquire and allocate the computing resources they need. The serverless programming model provides an abstraction for decomposing applications to map onto disaggregated hardware. Such disaggregated hardware is frequently connected directly to the network without the need or delay associated with host intervention. Such network-connected hardware can serve both as an attacker and as a defender from security breaches. In this talk, I will focus on network-attached FPGAs available in the Open Cloud Testbed (OCT) https://octestbed.org/. These FPGAs do not run an operating system, so there are no checks on the data sent out on the network. Thus, they can easily launch attacks such as Denial of Service (DoS) by flooding the network with packets. These FPGAs can also monitor traffic on the network directly, and identify such attacks. Nowadays, FPGAs are both pets and cattle, as well as having the potential to be either the attacker or the defender in disaggregated cloud computing. https://cassyni-user-files-prod.s3.amazonaws.com/JsVs8YysqQj38uhQzbPa5c https://cassyni.com/slides/outline/LDiYAUiECZdwDF1xLCiogy https://cassyni.com/events/LDiYAUiECZdwDF1xLCiogy/abstract https://cassyni-user-files-prod.s3.amazonaws.com/GTLL74hwJLN92RbhKu6SHt https://cassyni.com/events/LDiYAUiECZdwDF1xLCiogy?videoPreview=1 Does oxytocin increase trust in humans? Can humans trust oxytocin research?nohttps://cassyni.com/events/LDiYAUiECZdwDF1xLCiogy?videoPreview=12022-10-17T17:00:00+00:004017.36DeSci FoundationThis time, we invited Prof. Gideon Nave to speak about the replication crisis: 'Does oxytocin increase trust in humans? Can humans trust oxytocin research?'https://cassyni-user-files-prod.s3.amazonaws.com/GTLL74hwJLN92RbhKu6SHt https://cassyni.com/events/T5aQW8HXAbSAxquR3fQE1/seminar/qa https://cassyni.com/slides/outline/T5aQW8HXAbSAxquR3fQE1 https://cassyni.com/events/T5aQW8HXAbSAxquR3fQE1/abstract https://cassyni-user-files-prod.s3.amazonaws.com/9qnSbdb7QZySyC179LbP3L https://cassyni.com/events/T5aQW8HXAbSAxquR3fQE1?videoPreview=1 Integrated Electrocoagulation/Ultrafiltration-Membrane Distillation-Crystallization for Treating Hydraulic Fracturing Produced Waternohttps://cassyni.com/events/T5aQW8HXAbSAxquR3fQE1?videoPreview=12023-09-21T12:00:00+00:003754.68ElsevierIn this work, produced water (PW) generated from hydraulic fracturing was treated using an integrated electrocoagulation/ultrafiltration, membrane distillation and crystallization processes (EC/UF-MDC). The focus of this work was to determine the feasibility of this integrated process for increasing water recovery. The results of this work suggest that optimizing the various unit operations in this integrated process could be used to recover PW. All membrane based separation processes suffer from membrane fouling. Pretreatment of the feed is essential to suppress fouling of the membrane. Here electrocoagulation (EC) followed by ultrafiltration (UF) was used to achieve high removal efficiency of both total suspended solids (TSS) and total organic carbon (TOC). Dissolved organic compounds are known to foul the hydrophobic membrane used in MD. In this study, a significant reduction in membrane fouling was obtained, which can lead to a long-term durability of MD system. In addition, the use of membrane distillation crystallization (MDC) can help mitigate the scale formation. Crystallization in the feed tank was used to suppress scale formation on the MD membrane. The integrated EC/UF-MDC process can have a potential impact on Water Resources/Oil & Gas Companies. By treating and reusing PW, preservation of surface and groundwater forming 80% of the water utilized in hydraulic fracturing could be achieved. In addition, treating PW will reduce the amount of PW directly disposed in Class II disposal wells, which further address the main cause of earthquakes. https://cassyni-user-files-prod.s3.amazonaws.com/9qnSbdb7QZySyC179LbP3L https://cassyni.com/slides/outline/WbLE8qJFRBGMjkK6MJfhNV https://cassyni.com/events/WbLE8qJFRBGMjkK6MJfhNV/abstract https://cassyni-user-files-prod.s3.amazonaws.com/S2m1MzZkYGdUqkti33fiHk https://cassyni.com/events/WbLE8qJFRBGMjkK6MJfhNV?videoPreview=1 Granular matter self-organises by entropy-stability competition into non-equilibrium detailed balance statesnohttps://cassyni.com/events/WbLE8qJFRBGMjkK6MJfhNV?videoPreview=12021-06-16T12:00:00+00:004574.88Granular MatterThe large-scale behaviour of granular materials is sensitive to the grain-scale structure. This structure self-organises in a way that depends on the driving dynamic process, often regarded as history-dependence. It is therefore important to find a general underlying principle that applies to a wide range of dynamic processes. In this talk, I present a couple of steps in this direction. I will first describe a recently-developed formalism to model structural organisation of two-dimensional dense granular matter. The formalism makes it possible to predict a number of structural characteristics under any quasi-static process. A particularly surprising discovery is that the steady states of such dynamics satisfy a non-equilibrium detailed balance. I then present evidence that underlying the self-organisation is a general principle of competition between entropy and mechanical stability. It is possible to reduce the effect of mechanical stability, in which case some structural characteristics can be predicted from the maximum entropy principle alone. The theoretical predictions are supported by numerical and experimental observations. These results lend further support to Sir Sam Edwards’s proposal that much of granular science can be modelled by statistical mechanics.https://cassyni-user-files-prod.s3.amazonaws.com/S2m1MzZkYGdUqkti33fiHk https://cassyni.com/events/RerBfzq12bjLLebkLpxheM/seminar/qa https://cassyni.com/slides/outline/RerBfzq12bjLLebkLpxheM https://cassyni.com/events/RerBfzq12bjLLebkLpxheM/abstract https://cassyni-user-files-prod.s3.amazonaws.com/2oCKMzLiZCzREj3EXgDMGS https://cassyni.com/events/RerBfzq12bjLLebkLpxheM?videoPreview=1 Simulating a Thermoacoustic Engine With PyFRnohttps://cassyni.com/events/RerBfzq12bjLLebkLpxheM?videoPreview=12023-10-19T14:00:00+00:002967.24PyFRThermoacoustic engines can convert heat into acoustic energy, generating powerful acoustic waves that can be used for electricity generation, cooling and additional uses. Simulating them and predicting their performance is a challenging task, due to the multiple length and time scales involved, the characteristics of the flow (compressible, transient), and the sensitivity of these devices to small deviations in working conditions. In this talk, I will present high-fidelity simulations of a standing-wave thermoacoustic engine, based on solution of 2D and 3D compressible Navier stokes equations using PyFR. I will discuss the unprecedented accuracy of these results and some interesting insights about non-linear effects in thermoacoustic engines.https://cassyni-user-files-prod.s3.amazonaws.com/2oCKMzLiZCzREj3EXgDMGS https://cassyni.com/slides/outline/6PZcsLbXuk8Ta4ZFRXNPx9 https://cassyni.com/events/6PZcsLbXuk8Ta4ZFRXNPx9/abstract https://cassyni-user-files-prod.s3.amazonaws.com/D1RkosMCeejfTbmr4QJapW https://cassyni.com/events/6PZcsLbXuk8Ta4ZFRXNPx9?videoPreview=1 Holographic visualization: signal processing and technological challengesnohttps://cassyni.com/events/6PZcsLbXuk8Ta4ZFRXNPx9?videoPreview=12023-04-06T12:30:00+00:003436.92Journal on Image and Video Processing3D visualization has received increased attention in recent years, significantly boosted by the advent of new AR/VR/XR display devices and the metaverse paradigm. However, current display solutions based on - for example - stereoscopic or light field representations still depict significant shortcomings regarding, e.g., supported viewing angle and eye accommodation. Using the holographic modality instead might bring a solution to the encountered problems. Though the term holography is often misused because of marketing reasons – the name is often linked with ideal 3D visualization solutions – real holography uses a wave-based light propagation model instead of the ray-based models used for regular 3D visualization systems. Notwithstanding the big promises of holography and the evolution of the underlying supporting technologies, the challenges of bringing this technology to the professional and consumer markets are still huge. This talk will focus on the challenges related to the generation, processing, coding, and quality assessment of holographic content in combination with the underlying computation, optoelectronic, optical and photonics hardware. In this context, also the status of JPEG Pleno, currently defining the first international standard for coding of holographic content, will be discussed.https://cassyni-user-files-prod.s3.amazonaws.com/D1RkosMCeejfTbmr4QJapW https://cassyni.com/slides/outline/8roe6kqA72tww12oyDH2g5 https://cassyni.com/events/8roe6kqA72tww12oyDH2g5/abstract https://cassyni-user-files-prod.s3.amazonaws.com/CdwZ2McZKZKdt5ZjbMJvC6 https://cassyni.com/events/8roe6kqA72tww12oyDH2g5?videoPreview=1 Real or Fake? The Future of Biometric Data Protectionnohttps://cassyni.com/events/8roe6kqA72tww12oyDH2g5?videoPreview=12021-05-06T12:30:00+00:003794.76Journal on Image and Video ProcessingNo abstracthttps://cassyni-user-files-prod.s3.amazonaws.com/CdwZ2McZKZKdt5ZjbMJvC6 https://cassyni.com/events/GGXho1Y2guCnRaZGw68m65/seminar/qa https://cassyni.com/slides/outline/GGXho1Y2guCnRaZGw68m65 https://cassyni.com/events/GGXho1Y2guCnRaZGw68m65/abstract https://cassyni-user-files-prod.s3.amazonaws.com/X656haTXUtc6U8HSLuAjkr https://cassyni.com/events/GGXho1Y2guCnRaZGw68m65?videoPreview=1 On Consequence and Rejection as Operatorsnohttps://cassyni.com/events/GGXho1Y2guCnRaZGw68m65?videoPreview=12023-09-20T14:00:00+00:004948.72Logica UniversalisThis paper is devoted to the concepts of consequence and rejection, formulated as operators on a nonempty set of sentences, which may initially be unstructured. One of the issues that we pay attention to is the “cyclicity” of these concepts when they are defined one through the other. In addition, we explore this cyclicity, when the set of all sentences acquires some structure, or we can assume some structure of sentences in the sense that the operation of substitution can be applied to them.https://cassyni-user-files-prod.s3.amazonaws.com/X656haTXUtc6U8HSLuAjkr https://cassyni.com/slides/outline/BL3fLB4nJKfm2UqvvcRmMw https://cassyni.com/events/BL3fLB4nJKfm2UqvvcRmMw/abstract https://cassyni-user-files-prod.s3.amazonaws.com/SMDQpRwiA9sEm1hN6bxfYi https://cassyni.com/events/BL3fLB4nJKfm2UqvvcRmMw?videoPreview=1 How a fungus overcomes the defense of C. elegansnohttps://cassyni.com/events/BL3fLB4nJKfm2UqvvcRmMw?videoPreview=12023-05-04T11:00:00+00:002057.88Cassyni SeminarsDr. Reinhard Fischer from Karlsruhe Institute of Technology, Germany beautifully explains the delicate molecule dialogue during predatory interaction between nematode-trapping fungi and worms. https://cassyni-user-files-prod.s3.amazonaws.com/SMDQpRwiA9sEm1hN6bxfYi https://cassyni.com/events/MhgyRAAgvJDuhTqUEHK6g5/seminar/qa https://cassyni.com/slides/outline/MhgyRAAgvJDuhTqUEHK6g5 https://cassyni.com/events/MhgyRAAgvJDuhTqUEHK6g5/abstract https://cassyni-user-files-prod.s3.amazonaws.com/9xwqroVzWw7X4f67BpnExW https://cassyni.com/events/MhgyRAAgvJDuhTqUEHK6g5?videoPreview=1 Wastewater Treatment Strategies in Dairy Processingnohttps://cassyni.com/events/MhgyRAAgvJDuhTqUEHK6g5?videoPreview=12024-04-10T07:00:00+00:003555.04ElsevierThis presentation will give an overview of the challenges facing the global dairy processing industry in their treatment of wastewater streams. It will then focus on some technologies that can be used to reduce both the water and energy footprint of the industry. The topics covered will include the removal of lactic acid from acid whey, the generation of cleaning chemicals from salty whey and the use of membrane distillation for water recovery. https://cassyni-user-files-prod.s3.amazonaws.com/9xwqroVzWw7X4f67BpnExW https://cassyni.com/slides/outline/JF9k6Ne1r6MGfmXuacw99F https://cassyni.com/events/JF9k6Ne1r6MGfmXuacw99F/abstract https://cassyni-user-files-prod.s3.amazonaws.com/WooYhmhtMUw52nUnxrxQWA https://cassyni.com/events/JF9k6Ne1r6MGfmXuacw99F?videoPreview=1 Patterns and predictors of anxiety and depression symptom trajectories in patients diagnosed with primary brain tumorsnohttps://cassyni.com/events/JF9k6Ne1r6MGfmXuacw99F?videoPreview=12023-11-27T21:00:00+00:001880.88Journal of Neuro-OncologyJoin Journal of Neuro-Oncology Editor-In-Chief, Dr. Jason Sheehan, and Associate Editor, Dr. Randy D'Amico, for a discussion with Dr. Ashley Parham Ghiaseddin, Dr. Alayna Ernster, and Dr. Deidre Pereira about their latest article on the and predictors of anxiety and depression symptom trajectories in patients diagnosed with primary brain tumors.https://cassyni-user-files-prod.s3.amazonaws.com/WooYhmhtMUw52nUnxrxQWA https://cassyni.com/events/GmCvxKhSXigcF3YnjCFjGH/seminar/qa https://cassyni.com/slides/outline/GmCvxKhSXigcF3YnjCFjGH https://cassyni.com/events/GmCvxKhSXigcF3YnjCFjGH/abstract https://cassyni-user-files-prod.s3.amazonaws.com/MCk57U7oyRPV8PczEcHYfQ https://cassyni.com/events/GmCvxKhSXigcF3YnjCFjGH?videoPreview=1 Nonlinear Reduced-Order Modeling from Datanohttps://cassyni.com/events/GmCvxKhSXigcF3YnjCFjGH?videoPreview=12024-02-22T15:00:00+00:002292.28Nonlinear Dynamics, an International Journal of Nonlinear Dynamics and Chaos in Engineering SystemsI discuss a recent dynamical-systems-based alternative to machine learning in the data-driven reduced-order modeling of nonlinear phenomena. Specifically, spectral submanifolds (SSMs) represent very low-dimensional attractors in a large family of physical problems ranging from wing oscillations to transitions in pipe flows. A data-driven identification of the reduced dynamics on these SSMs gives a rigorous way to construct accurate and predictive reduced-order models for solids, fluids, and controls without the use of governing equations. I illustrate this on problems that include accelerated finite-element simulations of large structures, prediction of transitions in pipe flows, reduced-order modeling of fluid sloshing in a tank, and model-predictive control of soft robots.https://cassyni-user-files-prod.s3.amazonaws.com/MCk57U7oyRPV8PczEcHYfQ https://cassyni.com/events/9MUsG4zZwrP6V1MtB2e6pD/seminar/qa https://cassyni.com/slides/outline/9MUsG4zZwrP6V1MtB2e6pD https://cassyni.com/events/9MUsG4zZwrP6V1MtB2e6pD/abstract https://cassyni-user-files-prod.s3.amazonaws.com/5fSRd9gpKWXCbVCsxosdiv https://cassyni.com/events/9MUsG4zZwrP6V1MtB2e6pD?videoPreview=1 Radial Basis Functions for Solving PDEs: Advances Over The Last 25 Yearsnohttps://cassyni.com/events/9MUsG4zZwrP6V1MtB2e6pD?videoPreview=12024-01-08T16:00:00+00:003845.48Journal of Computational PhysicsThis talk will be given in layman’s terms. Radial Basis Functions (RBFs) were introduced in the 1970s, first as a tool for interpolating scattered 2-D data. Since then, both our knowledge about RBFs and their range of applications have grown tremendously, with the numerical solution of partial differential equations becoming a particularly important one. We will start off by introducing what an RBF is and why they are so special compared to other basis functions. We will then discuss how they can be seen as a generalization of finite difference and pseudospectral methods. Next, we demonstrate how to calculate discrete derivative operators with RBFs. Lastly, with a variety of examples, we will illustrate how RBF methodologies provide a promising innovative approach to numerically solving PDEs to high-order accuracy in arbitrary geometries, demonstrating both performance and scalability on highly parallel computer architectures. https://cassyni-user-files-prod.s3.amazonaws.com/5fSRd9gpKWXCbVCsxosdiv https://cassyni.com/slides/outline/QAxcmCvCWwvAt6meye3uJu https://cassyni.com/events/QAxcmCvCWwvAt6meye3uJu/abstract https://cassyni-user-files-prod.s3.amazonaws.com/JG5aRWdsve18kDU4wTCqVp https://cassyni.com/events/QAxcmCvCWwvAt6meye3uJu?videoPreview=1 Gas dynamics in protoplanetary disksnohttps://cassyni.com/events/QAxcmCvCWwvAt6meye3uJu?videoPreview=12022-05-12T12:00:00+00:001853.44Leeds Institute for Fluid DynamicsNo abstracthttps://cassyni-user-files-prod.s3.amazonaws.com/JG5aRWdsve18kDU4wTCqVp https://cassyni.com/events/Uco4BMjvU4uRLkXStHpUTP/seminar/qa https://cassyni.com/slides/outline/Uco4BMjvU4uRLkXStHpUTP https://cassyni.com/events/Uco4BMjvU4uRLkXStHpUTP/abstract https://cassyni-user-files-prod.s3.amazonaws.com/HpFsHjkfp6WBjXXKxtKkte https://cassyni.com/events/Uco4BMjvU4uRLkXStHpUTP?videoPreview=1 Disordered acoustic materials with target scattering propertiesnohttps://cassyni.com/events/Uco4BMjvU4uRLkXStHpUTP?videoPreview=12024-03-12T14:00:00+00:003967.04MetaMATThe ability to manipulate waves has long been one of the main goals in various areas of physics and engineering. Many-body scattering systems [1] and metamaterials [2] offer promising prospects to deal with this challenge due to their ability to be tuned and reconfigured. Properly designed highly disordered many-body systems have recently attracted attention as a tool for scattering manipulation. The introduction of local correlations between the positions of the scatterers constituting the disordered system allows to control the scattering of an incident radiation [3, 4, 5, 6, 7]. In particular, stealth materials consist of multiple scatterers distributed a way that completely suppress the scattering of the sample over a broadband frequency range [8, 9]. In this work, we develop a route to engineer acoustic materials consisting of multiple scatterers, which possess the desired scattering properties under the incidence of a plane wave. We characterize the scattering pattern of a set of scatterers under the approach of weak scattering by its structure factor. We validate this hypothesis calculating the scattered far-field amplitude using the multiple scattering theory that considers all scattering orders. We develop an optimization technique, which optimizes the positions of scatterers that lead to a chosen value of the structure factor over a given frequency range. Acknowledgements: Author is grateful for the partial support under Grant No. PID2020-112759GB-I00 funded by MCIN/AEI/10.13039/501100011033 and from Grant No. CIAICO/2022/052 of the “Programa para la promoción de la investigación científica, el desarrollo tecnológico y la innovación en la Comunitat Valenciana” funded by Generalitat Valenciana.https://cassyni-user-files-prod.s3.amazonaws.com/HpFsHjkfp6WBjXXKxtKkte https://cassyni.com/slides/outline/LiPmKnse3P7m2i1U8JqmsB https://cassyni.com/events/LiPmKnse3P7m2i1U8JqmsB/abstract https://cassyni-user-files-prod.s3.amazonaws.com/EzZgW6rCC4bqGSAeiZmM7t https://cassyni.com/events/LiPmKnse3P7m2i1U8JqmsB?videoPreview=1 Introducing Transformative Plant Biotechnology: The Road Less Travelled – Translating Discovery into Product: Lessons from the Rothamsted Omega-3 Projectnohttps://cassyni.com/events/LiPmKnse3P7m2i1U8JqmsB?videoPreview=12023-09-21T13:00:00+00:001870.0The New Phytologist FoundationFor over two decades now we have been evaluating the production omega-3 LC-PUFAs in transgenic plants, to provide a sustainable source of these important nutrients independent of oceanic sources. Attempts to metabolically engineer plants with the algal biosynthetic pathway for LC-PUFAs has ultimately led to the production of a transgenic oilseed crop (Camelina sativa) which contains over 20% omega-3 LC-PUFAs EPA+DHA in its seed oil. This omega-3 trait represents the most complex plant metabolic engineering trait to attempt the transition from research phase into development, regulatory approval and commercialisation, and all of these represent activities beyond the normal scope of academic research. Given the pressing need for answers to the global challenges facing the human race, more focus and effort should be placed on translation and my talk will consider how this can be achieved without comprising curiosity-driven research. Specifically, there are many lessons from our omega-3 project which might yield useful learnings. The fact that it takes 25 years to get to a point where impact is only now likely to be realised also confirms the need for realistic estimates in the time required for basic research to delivery societal benefits. https://cassyni-user-files-prod.s3.amazonaws.com/EzZgW6rCC4bqGSAeiZmM7t https://cassyni.com/slides/outline/U87q23aWdFRbXHXw6BhWHB https://cassyni.com/events/U87q23aWdFRbXHXw6BhWHB/abstract https://cassyni-user-files-prod.s3.amazonaws.com/LiWXyMCznzQnyqwqyRvUJr https://cassyni.com/events/U87q23aWdFRbXHXw6BhWHB?videoPreview=1 Machine Learning Anomaly Detection using Binary Visualisationnohttps://cassyni.com/events/U87q23aWdFRbXHXw6BhWHB?videoPreview=12021-09-06T12:00:00+00:003669.36Discover Applied SciencesInternet of Things devices have seen a rapid growth in recent years. The ubiquity of IoT devices with the limitation of resources, it is becoming increasingly harder to protect against security threats such as malware due to the fact that they are evolving faster than the defence mechanisms. The traditional security systems are not able to detect unknown malware as they use signature-based methods. In this work we aim to address this issue by introducing a novel IoT malware traffic analysis approach using machine learning and binary visualisation. The work was supported by European Union under the CYBER-TRUST project https://cyber-trust.eu/ which aims to develop an innovative cyber-threat intelligence gathering, detection, and mitigation platform, as well as, to perform high quality interdisciplinary research in key areas for introducing novel concepts and approaches to tackle the grand challenges towards securing the ecosystem of IoT devices.https://cassyni-user-files-prod.s3.amazonaws.com/LiWXyMCznzQnyqwqyRvUJr https://cassyni.com/slides/outline/wkoZpHhMz5FzRqRD9nNQD https://cassyni.com/events/wkoZpHhMz5FzRqRD9nNQD/abstract https://cassyni-user-files-prod.s3.amazonaws.com/8Q33dwRS5rzv1yy3uDSNP8 https://cassyni.com/events/wkoZpHhMz5FzRqRD9nNQD?videoPreview=1 Building Research Collaboration in Global Environmentsnohttps://cassyni.com/events/wkoZpHhMz5FzRqRD9nNQD?videoPreview=12023-11-02T12:00:00+00:003679.84Nature Mental HealthGood collaboration is important for success in many areas of our lives and is absolutely essential for research. Collaboration is the logical choice for institutions and researchers and has become increasingly commonplace. The number of authors per publication has increased across all disciplines since the 1980s, and international collaboration has been found to have increased from 14% to 24% of papers. Join this one-hour webinar presented by Springer Nature, Choice, and the ACRL, where our guests Rebecca Cooney, PhD, Chief Editor of Nature Mental Health, and Simon Baker, Chief Editor of Nature Index, will be sharing latest insights and discussing the following topics: - Data insights on current research trends globally - Collaboration and big science - Current findings about global North-South collaboration - How science in cities can benefit rural areas through collaboration - The benefits of collaboration - Facilitating research collaboration from editorial perspective - Roles that librarians and information managers can play to support their researchershttps://cassyni-user-files-prod.s3.amazonaws.com/8Q33dwRS5rzv1yy3uDSNP8 https://cassyni.com/slides/outline/BpitVVEC999aqwqSiiYjY9 https://cassyni.com/events/BpitVVEC999aqwqSiiYjY9/abstract https://cassyni-user-files-prod.s3.amazonaws.com/SKeGEyNhB6BFNY3bk6w7tS https://cassyni.com/events/BpitVVEC999aqwqSiiYjY9?videoPreview=1 Variable Energy Flux in Turbulencenohttps://cassyni.com/events/BpitVVEC999aqwqSiiYjY9?videoPreview=12020-10-23T12:00:00+00:003805.28Leeds Institute for Fluid DynamicsIn three-dimensional hydrodynamic turbulence forced at large length scales, a constant energy flux Πu flows from large scales to intermediate scales, and then to small scales. It is well known that for multiscale energy injection and dissipation, the energy flux Πu varies with scales. In this review we describe this principle and show how this general framework is useful for describing a variety of turbulent phenomena. Compared to Kolmogorov’s spectrum, the energy spectrum steepens in turbulence involving quasi-static magnetofluid, Ekman friction, stable stratification, magnetohydrodynamics, and solution with dilute polymer. However, in turbulent thermal convection, in unstably stratified turbulence such as RayleighTaylor turbulence, and in shear turbulence, the energy spectrum has an opposite behaviour due to an increase of energy flux with wavenumber. In addition, we briefly describe the role of variable energy flux in quantum turbulence, in binary-fluid turbulence including time-dependent Landau-Ginzburg and Cahn-Hillianrd equations, and in Euler turbulence.https://cassyni-user-files-prod.s3.amazonaws.com/SKeGEyNhB6BFNY3bk6w7tS https://cassyni.com/slides/outline/Vc6GGj2yLz1a1WMSzGHoGH https://cassyni.com/events/Vc6GGj2yLz1a1WMSzGHoGH/abstract https://cassyni-user-files-prod.s3.amazonaws.com/HteV9Uo7qK2d56kzvHawcJ https://cassyni.com/events/Vc6GGj2yLz1a1WMSzGHoGH?videoPreview=1 The ubiquitous acoustic bubble: a brief introductionnohttps://cassyni.com/events/Vc6GGj2yLz1a1WMSzGHoGH?videoPreview=12023-02-17T12:00:00+00:003578.36UK Fluids NetworkThere are few objects in nature that interact with acoustic waves as effectively and efficiently as a gas bubble in a liquid. The velocity, intensity and even frequency content of sound waves are profoundly impacted by bubbles in suspension, and when high-pressure waves travel through a liquid medium, they nucleate small gas bubbles that subsequently respond to period acoustic forcing, a process known as acoustic cavitation. Cavitation bubbles convert acoustical energy to mechanical energy that is highly concentrated in both space and time. The result is a plethora of mechanical, and thermal effects, ranging from acoustic micro-streaming to extreme conditions at the point of cavity collapse. All of these effects play a role, to varying degrees, in a broad range of industrial and biomedical procedures involving ultrasound. In this talk, we present an introductory overview of the relevant bubble physics, physical effects, and the roles – both beneficial and detrimental – played by bubbles and cavitation in industrial and medical acoustics.https://cassyni-user-files-prod.s3.amazonaws.com/HteV9Uo7qK2d56kzvHawcJ https://cassyni.com/slides/outline/Kj9oTgcMyBryJU3pmGTsky https://cassyni.com/events/Kj9oTgcMyBryJU3pmGTsky/abstract https://cassyni-user-files-prod.s3.amazonaws.com/KogrHYpt2DakmEoXDkTUzi https://cassyni.com/events/Kj9oTgcMyBryJU3pmGTsky?videoPreview=1 Revisiting the subtyping of bowel-based disorders using unsupervised machine learningnohttps://cassyni.com/events/Kj9oTgcMyBryJU3pmGTsky?videoPreview=12024-09-04T00:00:00+00:002133.32Auckland Bioengineering InstituteThe Rome IV criteria, a widely used symptom-based diagnostic tool for disorders of gut-brain interaction (DGBI), have enabled clinicians to provide diagnoses for patients whose gastrointestinal (GI) symptoms lack organic explanations. However, challenges remain in identifying robust diagnostic biomarkers, predicting treatment outcomes, and ensuring diagnostic stability. Unsupervised machine learning can be used to step beyond existing clinical definitions to uncover intrinsic patient subtypes possibly unburdened by these limitations. In this talk, Jarrah will provide an overview of bowel-based DGBI subtyping, present the findings from his recent application of unsupervised machine learning to revisit this problem, and introduce his next steps in improving DGBI diagnosis and treatment strategies.https://cassyni-user-files-prod.s3.amazonaws.com/KogrHYpt2DakmEoXDkTUzi https://cassyni.com/slides/outline/S9Z2wwWJGn8vyp3tLbuqjT https://cassyni.com/events/S9Z2wwWJGn8vyp3tLbuqjT/abstract https://cassyni-user-files-prod.s3.amazonaws.com/KKDoibyDzZ3MA1M5tyPLva https://cassyni.com/events/S9Z2wwWJGn8vyp3tLbuqjT?videoPreview=1 Aligning Public Safety with Public Health to Reduce Addiction and Overdosenohttps://cassyni.com/events/S9Z2wwWJGn8vyp3tLbuqjT?videoPreview=12024-03-07T21:00:00+00:003728.16Family MedicineLearning Objectives: - Learn the mechanisms by which police drug enforcement can increase exposure to fatal overdose - Describe the effects a newly-opened overdose prevention center may have on community safety - Understand how public safety officials can collaborate with public health institutions to better protect the health of vulnerable populationshttps://cassyni-user-files-prod.s3.amazonaws.com/KKDoibyDzZ3MA1M5tyPLva https://cassyni.com/slides/outline/5QKf1ELFqYsfqpbc4UzVqw https://cassyni.com/events/5QKf1ELFqYsfqpbc4UzVqw/abstract https://cassyni-user-files-prod.s3.amazonaws.com/WD3D2AZtfwboG6MsW2rtYN https://cassyni.com/events/5QKf1ELFqYsfqpbc4UzVqw?videoPreview=1 Actuator Line Model for Wind Turbine Wake Prediction with PyFRnohttps://cassyni.com/events/5QKf1ELFqYsfqpbc4UzVqw?videoPreview=12024-01-25T13:00:00+00:002216.24PyFRSince the simulation of a large floating offshore wind turbines (FOWT) wind farm requires significant computational cost, it is important to develop an efficient and accurate numerical model to predict the horizontal axis wind turbine (HAWT) wake structure under complex situations. In this study, a numerical HAWT model based on the actuator line (AL) method and PyFR solver are proposed. In this model, the geometric models of the blades, nacelle, and tower are replaced by body force source terms, which can significantly reduce the computational cost. In addition, the flux reconstruction (FR) method is applied to obtain accurate wake characteristics with less mesh number. The result shows that the proposed AL-PyFR(N&T) model requires only 0.26 million mesh number to achieve a more accurate prediction of the wake velocity and turbulent kinetic energy (TKE), compared to 34.15 million mesh number for the blade-resolved model and 13.5 million mesh number for the AL-IB-LES model. The significant reduction in computational cost enables the simulation of large offshore wind farms.https://cassyni-user-files-prod.s3.amazonaws.com/WD3D2AZtfwboG6MsW2rtYN https://cassyni.com/events/5tztAYVfgNMVfHb7rb7U29/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Js5XnRyPSUKtpJKzaVm6eA https://cassyni.com/slides/outline/Ene8tDdEBFPwha4jycU4iZ https://cassyni.com/events/Ene8tDdEBFPwha4jycU4iZ/abstract https://cassyni-user-files-prod.s3.amazonaws.com/4Gzz6H6qdQYJ4UGhSVhQht https://cassyni.com/events/Ene8tDdEBFPwha4jycU4iZ?videoPreview=1 On the norm of the Riesz projection from L∞ to Lpnohttps://cassyni.com/events/Ene8tDdEBFPwha4jycU4iZ?videoPreview=12024-01-11T15:00:00+00:003535.12Journal of Mathematical SciencesWe will consider 2𝜋-periodic functions of countably many variables. Let 𝕋 = ℝ ∕ (2𝜋 ℤ) and 𝜇∞ denote the Haar measure on 𝕋∞ normalized so that 𝜇∞(𝕋∞) = 1. Any function 𝑓 ∈ 𝐿(𝕋∞) has the Fourier expansion where now the sum is taken over all 𝒌 = (𝑘1, 𝑘2, … ) with integers 𝑘1, 𝑘2, … , such that all these numbers but finitely many are equal to 0. We consider the Riesz operator 𝑅 defined on the space 𝐿2(𝕋∞). We prove that for any 𝑝 > 2, 𝑞 > 2 the Riesz operator is not a bounded operator from 𝐿𝑝 to 𝐿𝑞. The talk is based on a joint paper with Herve Queffélec, Eero Saksman, and Kristian Seip.https://cassyni-user-files-prod.s3.amazonaws.com/4Gzz6H6qdQYJ4UGhSVhQht https://cassyni.com/slides/outline/9rA6RP9ynfrvJUMPy8m4zR https://cassyni.com/events/9rA6RP9ynfrvJUMPy8m4zR/abstract https://cassyni-user-files-prod.s3.amazonaws.com/iFSoFw7wwh1iixUJCf1U2 https://cassyni.com/events/9rA6RP9ynfrvJUMPy8m4zR?videoPreview=1 Ipilimumab plus decitabine for patients with MDS or AML in posttransplant or transplant-naïve settingsnohttps://cassyni.com/events/9rA6RP9ynfrvJUMPy8m4zR?videoPreview=12024-10-17T18:00:00+00:003402.72Center for Cancer TrainingRecurrence of acute myeloid leukemia (AML) or myelodysplastic syndromes (MDS) after transplant has exceedingly poor outcome. In a prior study at our center, single agent CTLA-4 checkpoint inhibitor (ipilimumab) generated remissions in cases of AML with low disease burden at relapse with induction of graft-versus-host disease. We asked if we could augment the rate of remission with combination decitabine plus ipilimumab in patients regardless of disease burden and if the alloreactive environment generated after transplant was required for response. In the context of a phase 1 multi-site clinical trial supported by the NCI/ETCTN, we enrolled and treated 48 patients with decitabine/ipilimumab in cohorts separated by transplantation status to assess for safety and preliminary efficacy. We also collected blood/bone marrow from each patient at the same time points before, on-therapy and at time of relapse when relevant to study the local and systemic tumor immune infiltrates. We discovered that immune-related adverse events were frequent and manageable in most patients, the recommended phase 2 dose was the same regardless of transplant status, and we identified responders in both cohorts. Multiplex immunofluorescence (MIF) analyses of paired sequential bone marrows revealed increases in CD4+ T cells after ipilimumab, but we did not consistently observe increases in activated CD8+ T cells among responders. Immune monitoring using Cytof revealed increases in T regulatory cells after ipilimumab but no correlation with response. Transcriptome-based analyses and MIF revealed differences in AML patients with leukemia cutis (skin) compared to those with marrow involvement, including infiltration of memory T cells and higher expression of CTLA-4 and FOXP3. Altogether, detailed immune and molecular correlatives identified potential mechanisms of response and resistance to combination therapy in advanced MDS/AML patients.https://cassyni-user-files-prod.s3.amazonaws.com/iFSoFw7wwh1iixUJCf1U2 https://cassyni.com/events/NCPph6qzAUdWLdHcE4GEmB/abstract https://cassyni-user-files-prod.s3.amazonaws.com/A19CMw4r3rr2x48mcaNPft https://cassyni.com/slides/outline/QfdqvX5cMmPzhZmAmkAsV7 https://cassyni.com/events/QfdqvX5cMmPzhZmAmkAsV7/abstract https://cassyni-user-files-prod.s3.amazonaws.com/MyYgkrgzm3whCDFKLDoap6 https://cassyni.com/events/QfdqvX5cMmPzhZmAmkAsV7?videoPreview=1 Electrochemistrynohttps://cassyni.com/events/QfdqvX5cMmPzhZmAmkAsV7?videoPreview=12022-10-12T19:00:00+00:007824.8Thieme GroupElectrosynthesis represents an increasingly viable platform for molecular synthesis that is currently undergoing a remarkable renaissance.https://cassyni-user-files-prod.s3.amazonaws.com/MyYgkrgzm3whCDFKLDoap6 https://cassyni.com/slides/outline/HFunEGNjmu6UwXaGDaZF33 https://cassyni.com/events/HFunEGNjmu6UwXaGDaZF33/abstract https://cassyni-user-files-prod.s3.amazonaws.com/RbBok3WTMs2g54Kwh4ymJe https://cassyni.com/events/HFunEGNjmu6UwXaGDaZF33?videoPreview=1 Non-Hermitian Topological Magnonicsnohttps://cassyni.com/events/HFunEGNjmu6UwXaGDaZF33?videoPreview=12024-10-04T12:00:00+00:002993.04Physics ReportsAs elementary excitations of ordered magnetic moments that exist in various magnetic materials, magnons are the information carriers in magnonic devices with low-energy consumption for reprogrammable logic, non-reciprocal communication, and non-volatile memory functionalities. Non-Hermitian topological magnonics deals with the engineering of dissipation and/or gain for non-Hermitian topological phases or properties in magnets that are not achievable in the conventional Hermitian scenario, with associated functionalities cross-fertilized with their electronic, acoustic, optic, and mechanic counterparts, such as giant enhancement of magnonic frequency combs, magnon amplification, (quantum) sensing of the magnetic field with unprecedented sensitivity, magnon accumulation, and perfect absorption of microwaves. In this talk, I will address the unified approach in constructing magnonic non-Hermitian Hamiltonian, introduce the basic non-Hermitian topological physics, and provide a comprehensive overview of the recent theoretical and experimental progress towards achieving distinct non-Hermitian topological phases or properties in magnonic devices, including exceptional points, exceptional nodal phases, non-Hermitian magnonic SSH model, and non-Hermitian skin effect. We emphasize the non-Hermitian Hamiltonian approach based on the Lindbladian or self-energy of the magnonic subsystem but address the physics beyond it as well, such as the crucial quantum jump effect in the quantum regime and non-Markovian dynamics. We provide a perspective for future opportunities and challenges in this field.https://cassyni-user-files-prod.s3.amazonaws.com/RbBok3WTMs2g54Kwh4ymJe https://cassyni.com/events/Y5MucmnUwdhqC9Hdjd2bu7/seminar/qa https://cassyni.com/slides/outline/Y5MucmnUwdhqC9Hdjd2bu7 https://cassyni.com/events/Y5MucmnUwdhqC9Hdjd2bu7/abstract https://cassyni-user-files-prod.s3.amazonaws.com/2z3vpERzmctaxA5hm7uTkz https://cassyni.com/events/Y5MucmnUwdhqC9Hdjd2bu7?videoPreview=1 On operators which attain their norm on every reducing subspacenohttps://cassyni.com/events/Y5MucmnUwdhqC9Hdjd2bu7?videoPreview=12024-03-25T09:00:00+00:003220.68Annals of Functional AnalysisIn this talk, first, we discuss the spectral properties of operators that attain their norm on every reducing subspace. Next, we explore the structure of normal and quasinormal operators in this class. At the end, we describe paranormal operators whose adjoint is also paranormal. This gives direct proof of the fact that an operator is normal if and only if the operator and its adjoint are paranormal.https://cassyni-user-files-prod.s3.amazonaws.com/2z3vpERzmctaxA5hm7uTkz https://cassyni.com/events/T8ss9wKEZ4Aoo3aHj9KcAy/abstract https://cassyni-user-files-prod.s3.amazonaws.com/2ATnPKwUeuDazizD5QtKWW https://cassyni.com/events/T8ss9wKEZ4Aoo3aHj9KcAy?videoPreview=1 A big, bright future for language science.nohttps://cassyni.com/events/T8ss9wKEZ4Aoo3aHj9KcAy?videoPreview=12024-02-29T23:00:00+00:002852.04Linguistics and Applied Language StudiesLinguistics is a subject with a proud past and an uncertain future. In theory, language science could be a vital hub discipline that links social sciences, humanities and the natural sciences. In this talk, I will outline some suggestions for how this could occur. I will discuss the importance of engaging with the challenges of big questions, big data, computational methods and working in big interdisciplinary teams. I will give examples of recent work in our Department of Linguistic and Cultural Evolution at the Max Planck Institute for Evolutionary Anthropology that attempts to meet these challenges.https://cassyni-user-files-prod.s3.amazonaws.com/2ATnPKwUeuDazizD5QtKWW https://cassyni.com/slides/outline/4uhg5BCcoTFLzXm7kce9DF https://cassyni.com/events/4uhg5BCcoTFLzXm7kce9DF/abstract https://cassyni-user-files-prod.s3.amazonaws.com/CjYBQ7UsZq2KT7QGwFkGqC https://cassyni.com/events/4uhg5BCcoTFLzXm7kce9DF?videoPreview=1 Smelling with the mouthparts in spotted lanternflynohttps://cassyni.com/events/4uhg5BCcoTFLzXm7kce9DF?videoPreview=12024-03-29T12:00:00+00:001114.4Royal Society PublishingDeciphering how spotted lanternfly (SLF), an invasive polyphagous planthopper in North America, engages with its environment is a pressing issue with fundamental biological significance and economic importance. This interaction primarily depends on olfaction. However, the cellular basis of olfaction in SLF remains elusive. Here we investigate the neuronal and functional organization of the subapical labial sensory organ using scanning electron microscopy and electrophysiological recordings. This organ is believed to supply planthoppers with crucial sensory information that influences their subsequent feeding behavior. We find in SLF that this organ comprises two identical placoid sensilla, each housing two distinct neurons. The A neuron displays a remarkable sensitivity to changes in airflow speed. Importantly, the same neuron also exhibits robust excitatory responses exclusively to three aldehydes out of a diverse pool of 86 tested odorants and inhibitory responses to 62 other odorants. By contrast, the B neuron solely serves as an olfactory detector, showing strong excitatory responses to 17 odorants and inhibitory responses to only three. The results provide a potential cellular basis for the behavioral responses of SLF to its ecologically relevant stimuli. Our study also identifies new odorants that may be useful for managing this serious pest.https://cassyni-user-files-prod.s3.amazonaws.com/CjYBQ7UsZq2KT7QGwFkGqC https://cassyni.com/events/DJiwroCYGEfL9s7apTyCS9/seminar/qa https://cassyni.com/slides/outline/DJiwroCYGEfL9s7apTyCS9 https://cassyni.com/events/DJiwroCYGEfL9s7apTyCS9/abstract https://cassyni-user-files-prod.s3.amazonaws.com/XPibfWC5vgswakxJj6qrDt https://cassyni.com/events/DJiwroCYGEfL9s7apTyCS9?videoPreview=1 Securing Cyber-Physical Systems: Economic Adoption and Risk Perception of Cybersecuritynohttps://cassyni.com/events/DJiwroCYGEfL9s7apTyCS9?videoPreview=12024-04-02T15:30:00+00:003276.48Data-Centric Engineering JournalWhile technological advances in hardware security and cyber-physical systems are important, how such technologies and systems are adopted and integrated are subject to a viable business case, efficient supply chain, and skills and communication. We share the results from an in-depth study of two dozen technology leaders to understand the drivers and barriers of secure hardware. Another aspect we address is cyber risk perception and governance of cyber-physical systems, based on a proposed scenario-based method engaging executive leadership of a large organisation in a cyber risk exercise. Across the two areas of research, we hope to share insights into the economics and governance of cybersecurity. https://cassyni-user-files-prod.s3.amazonaws.com/XPibfWC5vgswakxJj6qrDt https://cassyni.com/events/Fmxy6DSATXRpWob9N9sqA5/seminar/qa https://cassyni.com/slides/outline/Fmxy6DSATXRpWob9N9sqA5 https://cassyni.com/events/Fmxy6DSATXRpWob9N9sqA5/abstract https://cassyni-user-files-prod.s3.amazonaws.com/E6KbGzWZmqYb3pxqLUziq4 https://cassyni.com/events/Fmxy6DSATXRpWob9N9sqA5?videoPreview=1 Sensitivity analysis of biochemical systems using bond graphsnohttps://cassyni.com/events/Fmxy6DSATXRpWob9N9sqA5?videoPreview=12024-04-24T09:00:00+00:002473.84Royal Society PublishingThe sensitivity of systems biology models to parameter variation can give insights into which parameters are most important for physiological function, and also direct efforts to estimate parameters. However, in general, kinetic models of biochemical systems do not remain thermodynamically consistent after perturbing parameters. To address this issue, we analyse the sensitivity of biological reaction networks in the context of a bond graph representation. We find that the parameter sensitivities can themselves be represented as bond graph components, mirroring potential mechanisms for controlling biochemistry. In particular, a sensitivity system is derived which re-expresses parameter variation as additional system inputs. The sensitivity system is then linearized with respect to these new inputs to derive a linear system which can be used to give local sensitivity to parameters in terms of linear system properties such as gain and time constant. This linear system can also be used to find so-called sloppy parameters in biological models. We verify our approach using a model of the Pentose Phosphate Pathway, confirming the reactions and metabolites most essential to maintaining the function of the pathway.https://cassyni-user-files-prod.s3.amazonaws.com/E6KbGzWZmqYb3pxqLUziq4 https://cassyni.com/slides/outline/NhX1gVFaT4vxVRqhdQnwp9 https://cassyni.com/events/NhX1gVFaT4vxVRqhdQnwp9/abstract https://cassyni-user-files-prod.s3.amazonaws.com/E8NWpqTmzFrdgQUKpWxdfk https://cassyni.com/events/NhX1gVFaT4vxVRqhdQnwp9?videoPreview=1 Social evaluation of variation in NZSLnohttps://cassyni.com/events/NhX1gVFaT4vxVRqhdQnwp9?videoPreview=12024-08-16T04:10:00+00:002784.28Linguistics and Applied Language StudiesDigital technology has allowed NZSL informative texts to be shared online for unknown audiences, prompting development of a modern genre akin to ‘broadcast’ style. Our research compared the use of certain variants in online posts compared to face-to-face conversation, such as doubling of one-handed signs and open-handed vs index-finger pointing. We explore Deaf signers’ perceptions of the sociopragmatic impact of these features. https://cassyni-user-files-prod.s3.amazonaws.com/E8NWpqTmzFrdgQUKpWxdfk https://cassyni.com/events/PCAcjAu6tXV1VCNbDr5k5T/seminar/qa https://cassyni.com/slides/outline/PCAcjAu6tXV1VCNbDr5k5T https://cassyni.com/events/PCAcjAu6tXV1VCNbDr5k5T/abstract https://cassyni-user-files-prod.s3.amazonaws.com/HTRmijF8s5scfPMwHLriLv https://cassyni.com/events/PCAcjAu6tXV1VCNbDr5k5T?videoPreview=1 Vulnerability Assessment and Empowering Solutions for Women's Health in the Face of Climate Changenohttps://cassyni.com/events/PCAcjAu6tXV1VCNbDr5k5T?videoPreview=12024-07-18T08:00:00+00:003963.48Women's HealthClimate change has rapidly evolved to become a priority on the global health agenda, as it threatens to impact a wide range of social and environmental determinants of health. The catastrophic health impacts of extreme weather conditions, rising temperatures and sea levels could potentially impact the availability of clean air, safe drinking water, sufficient food, and secure shelter. The health effects of these disruptions could potentially translate into increased burden of diseases, injuries and premature deaths, alongside the debilitating impacts on mental health. Women across the world, especially from developing regions, are more likely to bear the worst effects and suffer poor physical and mental health, violence, and food insecurity. This Special Collection aims to report on the epidemiology of how climate change disproportionately impacts women’s health, discuss unique health challenges and case studies on innovations to address these challenges, with a specific focus on policies and advocacy for women residing in developing regions. https://cassyni-user-files-prod.s3.amazonaws.com/HTRmijF8s5scfPMwHLriLv https://cassyni.com/slides/outline/Hm2yDenL4VPw6L8Mcw5x61 https://cassyni.com/events/Hm2yDenL4VPw6L8Mcw5x61/abstract https://cassyni-user-files-prod.s3.amazonaws.com/AA827ShuAtEEjuGQSsvdUi https://cassyni.com/events/Hm2yDenL4VPw6L8Mcw5x61?videoPreview=1 Topological invisibility in chiral mirror latticesnohttps://cassyni.com/events/Hm2yDenL4VPw6L8Mcw5x61?videoPreview=12024-05-14T13:00:00+00:003086.04MetaMATThe hallmark of topological phases in periodic materials is the existence of localized modes on the edges. These modes benefit from topological protection, that renders them immune to backscattering over defects or disorder. However, in the context of classical waves such as in photonics or acoustics, total immunity to backscattering has never been achieved so far. In this presentation, I will show how to obtain not only perfect transmission but also invisbility of topological edge waves by exploiting the combination of chiral and mirror symmetry. This guarantees a unit transmission coefficient with a zero phase shift for edge waves scattering across symmetry preserving defects or disorder. https://cassyni-user-files-prod.s3.amazonaws.com/AA827ShuAtEEjuGQSsvdUi https://cassyni.com/events/YaV6cAC5EE1HLwqj8yZJx5/seminar/qa https://cassyni.com/slides/outline/YaV6cAC5EE1HLwqj8yZJx5 https://cassyni.com/events/YaV6cAC5EE1HLwqj8yZJx5/abstract https://cassyni-user-files-prod.s3.amazonaws.com/FDmTqT62fpuCCon5kY9JHC https://cassyni.com/events/YaV6cAC5EE1HLwqj8yZJx5?videoPreview=1 The fluid mechanics of buildingsnohttps://cassyni.com/events/YaV6cAC5EE1HLwqj8yZJx5?videoPreview=12024-05-22T13:00:00+00:003562.84Leeds Institute for Fluid DynamicsWe often take our buildings to be just the static structures, yet every day each of us requires about one million litres of air to flow into and around our buildings. Maintaining good indoor air quality is vital for our health, well-being, and productivity but conditioning that air for our comfort can cost the Earth. Improving our understanding of the fluid mechanics, and delivering successful solutions, is a grand challenge for society in realising the comfortable resilient sustainable buildings that we demand, and that our planet very much needs. In this talk, the traditional approach to modelling building air flows will be discussed in the context of some of our recent efforts following this tradition. Gaps between these efforts and suitable progress in resolving our grand challenge will be highlighted and alternative approaches will be presented; namely, assimilating measured data and probabilistic descriptions of indoor activities to estimate air flows in operational buildings. Ultimately, opportunities for us all to contribute to this challenge will be discussed.https://cassyni-user-files-prod.s3.amazonaws.com/FDmTqT62fpuCCon5kY9JHC https://cassyni.com/events/RAm2uuVCeMhmauepaowgW1/seminar/qa https://cassyni.com/slides/outline/RAm2uuVCeMhmauepaowgW1 https://cassyni.com/events/RAm2uuVCeMhmauepaowgW1/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Kppxi4P8tiqbx14yQV36Ja https://cassyni.com/events/RAm2uuVCeMhmauepaowgW1?videoPreview=1 Electoral Consequences for Black America: A Struggle on Two Simultaneous Frontsnohttps://cassyni.com/events/RAm2uuVCeMhmauepaowgW1?videoPreview=12024-10-17T16:00:00+00:003140.0Lived Places PublishingBlack Americans are uniquely placed within the phenomenon of American elections. In this conversation between Chris McAuley, Black Studies Collection Editor at Lived Places Publishing and Stephen Graves, author of [*At War With Politics: A Journey from Traditional Political Science to Black Politics*](https://livedplacespublishing.com/book/isbn/9781915271112?utm_source=MB&utm_medium=cassyni&utm_campaign=black-studies&utm_content=Graves), they examine the upcoming U.S. presidential election through the lens of Black politics. When situated within the “struggle” of Black politics, each election presents new opportunities with familiar adversaries and potential consequences. The “struggle” is twofold: 1) African Americans’ attempts for racial, social, and economic justice while simultaneously struggling against 2) the white dominant majority’s maintenance of power, the ability to find viable coalitions with other oppressed and disadvantaged groups, and to see their policy preferences turn into real policy. In the upcoming election, new issues such as the weaponization of DEI will replace older strategies scapegoating Black Americans for the declining standing of white Americans. American elections demand that African Americans prepare for the worst regardless of the electoral outcome: Either they become symbols of America’s decline and the depleting influence of white America or witness any progress they’ve made get stripped away. Ultimately, this seminar hopes to revisit traditional strategies while offering insight to new possibilities for Black politics.https://cassyni-user-files-prod.s3.amazonaws.com/Kppxi4P8tiqbx14yQV36Ja https://cassyni.com/events/Te149KipqeUFwr8P8VrKDw/abstract https://cassyni-user-files-prod.s3.amazonaws.com/TW21wwscUD1cLd3KQuMLr https://cassyni.com/events/8NiVLfVMinsPBG5tDCG1Xj/seminar/qa https://cassyni.com/slides/outline/8NiVLfVMinsPBG5tDCG1Xj https://cassyni.com/events/8NiVLfVMinsPBG5tDCG1Xj/abstract https://cassyni-user-files-prod.s3.amazonaws.com/6xyKL9ni5rnNFzhSECNDaW https://cassyni.com/events/8NiVLfVMinsPBG5tDCG1Xj?videoPreview=1 Multi-modal metamaterial panels for broadband sound insulation: efficient modelling and design optimizationnohttps://cassyni.com/events/8NiVLfVMinsPBG5tDCG1Xj?videoPreview=12024-06-18T12:00:00+00:003202.04MetaMATLocally resonant metamaterials can achieve unprecedented vibroacoustic attenuation in partition panels by subwavelength distributions of small attached resonators. However, conventional metamaterial panels employ single-mode transversal resonators and are effective only in a narrow band. This seminar discusses the potential of achieving broadband vibroacoustic attenuation through multi-modal metamaterials, which exploit multiple translational and rotational modes within a single resonator. To achieve efficient modelling, dedicated effective medium representations are developed through equivalent homogenized material properties, tailored to include multiple translational and rotational local resonances. For idealized metamaterial panels with infinite extent, the approach allows for the analytical prediction of the (multiple) bandgaps created for bending waves and of the resulting diffuse field sound transmission loss (STL). For real-world scenarios, the effects of finite size, boundary conditions, and non-uniform resonator distributions are included by coupling an effective medium-finite element model of the metamaterial panel with a diffuse model of the surrounding sound fields. An important design question is then addressed, that is how to achieve suitable local resonator layouts that obtain an adequate amount of resonances across the target frequency range. This problem is tackled by developing efficient numerical optimization methodologies that exploit effective medium modelling. The optimization objective is to maximize broadband diffuse STL while constraining the maximum mass of the attached resonators. As a showcase, the suppression of the broadband STL dip due to coincidence in orthotropic host plates is targeted. At first, promising resonator layouts based on physical insight are proposed and parametrically optimized. Afterwards, non-intuitive designs with an increased number of local resonances are obtained through density-based topology optimization, in which free material distribution is allowed for maximum design freedom. https://cassyni-user-files-prod.s3.amazonaws.com/6xyKL9ni5rnNFzhSECNDaW https://cassyni.com/slides/outline/3SESsq27LDLMnANYCiZ1ob https://cassyni.com/events/3SESsq27LDLMnANYCiZ1ob/abstract https://cassyni-user-files-prod.s3.amazonaws.com/3uYKeCWdJWc4h6pBnXAjZG https://cassyni.com/events/3SESsq27LDLMnANYCiZ1ob?videoPreview=1 Robust Modal Decompositions for Fluid Flowsnohttps://cassyni.com/events/3SESsq27LDLMnANYCiZ1ob?videoPreview=12020-05-30T14:00:00+00:00694.24Brunton LabThis research abstract by Isabel Scherl describes how to use robust principle component analysis (RPCA) for robust modal decompositions of fluid flows that have large outliers or corruption.https://cassyni-user-files-prod.s3.amazonaws.com/3uYKeCWdJWc4h6pBnXAjZG https://cassyni.com/events/Dor8rBc8YpxnJffgDpVuV7/abstract https://cassyni-user-files-prod.s3.amazonaws.com/BWzHxtZSwW2tDNPo6ASTbk https://cassyni.com/slides/outline/AMJuXQ5TUd69GyN7aA7wxH https://cassyni.com/events/AMJuXQ5TUd69GyN7aA7wxH/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Ry4E5sWyHZFBfHJvcUXCvJ https://cassyni.com/events/AMJuXQ5TUd69GyN7aA7wxH?videoPreview=1 Physics-based machine learning for quickly simulating transport-dominated physical phenomenanohttps://cassyni.com/events/AMJuXQ5TUd69GyN7aA7wxH?videoPreview=12021-11-19T14:00:00+00:003636.68AI Institute in Dynamic SystemsLatent dynamics of transport-dominated phenomena such as described by hyperbolic conservation laws typically exhibit nonlinear structures that make traditional model reduction in low-dimensional subspaces inefficient. In this presentation, we propose numerical time integration methods that propagate forward in time nonlinear parametrizations such as deep neural networks that can efficiently describe the latent dynamics of transport-dominated problems. The parameters are learned by integrating systems of differential equations given by the physics of the problem. This is different to collocation methods that fit the parameters by minimizing the residual based on samples from the space and time domain. Numerical results demonstrate that the proposed approach requires few degrees of freedom to accurately describe and predict transport-dominated dynamics. Furthermore, the approach is compatible with adaptive sampling schemes to efficiently approximate high-dimensional problems with spatially local features.https://cassyni-user-files-prod.s3.amazonaws.com/Ry4E5sWyHZFBfHJvcUXCvJ https://cassyni.com/slides/outline/CpYvkpK5furdduqg7r2agD https://cassyni.com/events/CpYvkpK5furdduqg7r2agD/abstract https://cassyni-user-files-prod.s3.amazonaws.com/AnyREfh8obxd9oXAGyfBUA https://cassyni.com/events/CpYvkpK5furdduqg7r2agD?videoPreview=1 Communication and collaboration in scientific researchnohttps://cassyni.com/events/CpYvkpK5furdduqg7r2agD?videoPreview=12024-06-06T15:40:00+00:003246.16New Phytologist Foundation A panel of mentors will share their experiences of working in different research cultures and collaboration, as well as experience with science communication and outreach. https://cassyni-user-files-prod.s3.amazonaws.com/AnyREfh8obxd9oXAGyfBUA https://cassyni.com/events/PgqqtV4WjLxqJfN71xCiFf/seminar/qa https://cassyni.com/slides/outline/PgqqtV4WjLxqJfN71xCiFf https://cassyni.com/events/PgqqtV4WjLxqJfN71xCiFf/abstract https://cassyni-user-files-prod.s3.amazonaws.com/PuDZ6mbPs6qvGgiiaEAyUA https://cassyni.com/events/PgqqtV4WjLxqJfN71xCiFf?videoPreview=1 Introduction to the 8th International Biometals Webinars, Metals, metabolites, and the variable host environment, Molecular mechanisms that regulate copper concentration in normal and diseased human cellsnohttps://cassyni.com/events/PgqqtV4WjLxqJfN71xCiFf?videoPreview=12024-10-01T13:00:00+00:005485.32BioMetalsGood morning, good afternoon, good night! Welcome to the 8th international webinars series For those who don't already know, these webinars have been set up by the international Biometals society and the journal Biometals with the help of Cassyni platform. • The aim of these webinars is to promote research in the field of metal in biology and to encourage the interdisciplinary exchange of information at international level. Mammalian metals homeostasis in the spotlight today! Welcome our two speakers First, Elizabeth Nolan from the Massachusetts institute of technology, in Cambridge, USA, will be talking about A fascinating protein, the calprotectin involved in nutritional immunity by metal withholding activity to prevent metal acquisition by the invading bacterial pathogens… So I suppose we'll be hearing about calcium ions and transition metal, such as iron, sequestion by Calprotection. High Faecal calciprotectin concentration can be a marker of various intestinal pathologies. Liz together with Janet J. Y. Peet published a review in Biometals in 2023 on Post‑translational modifications on the metal‑sequestering protein calprotectin. The second speaker is Svetlana Lutsenko from the Johns Hopkins medical faculty, in Baltimore. Her group is focused on the molecular mechanisms of copper homeostasis in normal and diseased cells. Copper and its various redox state are involved in several essential biological processes and its homeostasis should be tightly controlled. I am excited to ear more about the recent data, some unpublished that Svetlana is going to talk about today (part not recorded) ! This presentation will focus on the metal-sequestering host defense protein calprotectin (CP). Its coordination chemistry and and the working model for how CP contributes to metal limitation in the extracellular space will be described along with our current thinking regarding the importance of integrating environmental complexity and relevant physiological variables into this model. Two case studies highlighting consequences of the environment on CP structure and function will be presented. One case study will be focused on the interplay of CP, Fe and bacterial metabolites and the other on oxidative post-translational modifications. In mammalian cells, copper is utilized for energy production, protection against radical mediated damage, signaling and for determining cell identity. During cell differentiation, requirements for copper increase. At the same time, specific steps in cell differentiation program may require transient decrease of cytosolic copper. This is accomplished by coordinated upregulation and trafficking of copper transporters. This presentation will summarize the data on the role of copper homeostasis in cell differentiation and morphogenesis. The in vitro and in vivo (in mice) data will be shown illustrating how copper misbalance influence the ability of cells to acquire characteristic cell morphology. Published and unpublished data will be discussed https://cassyni-user-files-prod.s3.amazonaws.com/PuDZ6mbPs6qvGgiiaEAyUA https://cassyni.com/events/LEJcZhXqf96CGy4YNHpkiq/seminar/qa https://cassyni.com/slides/outline/LEJcZhXqf96CGy4YNHpkiq https://cassyni.com/events/LEJcZhXqf96CGy4YNHpkiq/abstract https://cassyni-user-files-prod.s3.amazonaws.com/JgPZW8AMx7YjcqnPzAwhwc https://cassyni.com/events/LEJcZhXqf96CGy4YNHpkiq?videoPreview=1 Terwilliger algebra of a graphnohttps://cassyni.com/events/LEJcZhXqf96CGy4YNHpkiq?videoPreview=12024-06-28T15:00:00+00:004178.04The Journal of Algebraic CombinatoricsIn algebraic combinatorics, the following situation occurs often. Let $\Gamma$ be a combinatorial object and let $H$ be a certain algebraic object, associated with $\Gamma$. In this case, one of the main motivations in our research is the following question: what could we say about the combinatorial properties of $\Gamma$, if we know that $H$ has certain algebraic properties? And vice-versa: what could we say about the algebraic properties of $H$, if we know that $\Gamma$ has certain combinatorial properties? Perhaps the most well-known example of this interplay between combinatorics and algebra is obtained if $H$ is the automorphism group of a graph $\Gamma$. In this case there are many relations between combinatorial properties of $\Gamma$ and algebraic properties of $H$. For example, if $H$ acts transitively on the set of vertices of $\Gamma$, then $\Gamma$ is regular (in a sense that every vertex of $\Gamma$ has the same number of neighbours). If we further know that the stabilizer $H_x$ of a vertex $x$ has exactly three orbits, then $\Gamma$ is strongly regular. There are other examples of this interplay available in the literature. In this talk the algebraic object, associated with $\Gamma$, will not be its automorphism group, but rather a certain matrix algebra, called a _Terwilliger algebra of a graph_ $\Gamma$. The main motivation, however, remains the same: what could we say about the combinatorial properties of $\Gamma$, if we know that its Terwilliger algebra has certain algebraic properties? And vice-versa: what could we say about the algebraic properties of the Terwilliger algebra of $\Gamma$, if we know that $\Gamma$ has certain combinatorial properties?https://cassyni-user-files-prod.s3.amazonaws.com/JgPZW8AMx7YjcqnPzAwhwc https://cassyni.com/events/WbvJY47rskicoUMgPPmeQM/seminar/qa https://cassyni.com/slides/outline/WbvJY47rskicoUMgPPmeQM https://cassyni.com/events/WbvJY47rskicoUMgPPmeQM/abstract https://cassyni-user-files-prod.s3.amazonaws.com/FTt5DgvMw9dVARurbFU9L https://cassyni.com/events/WbvJY47rskicoUMgPPmeQM?videoPreview=1 Seeking temporal refugia to heat stress: increasing nocturnal activity despite predation risknohttps://cassyni.com/events/WbvJY47rskicoUMgPPmeQM?videoPreview=12024-09-12T10:00:00+00:003534.52Royal Society PublishingFlexibility in activity timing may enable organisms to quickly adapt to environmental changes. Under global warming, diurnally adapted endotherms may achieve a better energy balance by shifting their activity towards cooler nocturnal hours. However, this shift may expose animals to new or increased environmental challenges (e.g. increased predation risk, reduced foraging efficiency). We analysed a large dataset of activity data from 47 ibex (Capra ibex) in two protected areas, characterized by varying levels of predation risk (presence versus absence of the wolf—Canis lupus). We found that ibex increased nocturnal activity following warmer days and during brighter nights. Despite the considerable sexual dimorphism typical of this species and the consequent different predation-risk perception, males and females demonstrated consistent responses to heat in both predator-present and predator-absent areas. This supports the hypothesis that shifting activity towards nighttime may be a common strategy adopted by diurnal endotherms in response to global warming. As nowadays different pressures are pushing mammals towards nocturnality, our findings emphasize the urgent need to integrate knowledge of temporal behavioural modifications into management and conservation planning. Image credit: Gary Kramer, Public domain, via Wikimedia Commonshttps://cassyni-user-files-prod.s3.amazonaws.com/FTt5DgvMw9dVARurbFU9L https://cassyni.com/slides/outline/MDbpf4ptY4CLwitYUGJ5Xj https://cassyni.com/events/MDbpf4ptY4CLwitYUGJ5Xj/abstract https://cassyni-user-files-prod.s3.amazonaws.com/WBRPJVqV2pgTnaMKGL2rLv https://cassyni.com/events/MDbpf4ptY4CLwitYUGJ5Xj?videoPreview=1 Abscisic acid acts essentially on stomata, not on xylem, to improve drought tolerancenohttps://cassyni.com/events/MDbpf4ptY4CLwitYUGJ5Xj?videoPreview=12024-06-08T13:45:00+00:00799.12New Phytologist Foundation Drought resistance is essential for plant production under water-limiting environments. Abscisic acid (ABA) plays a critical role in stomatal function during drought but its impact on hydraulic function beyond the stomata is less studied. We selected four tomato genotypes differing in their ability to accumulate ABA to investigate its role in drought-induced dysfunction. All genotypes displayed similar leaf and stem embolism resistance, along with comparable leaf hydraulic resistance. The only difference was observed between the two extreme genotypes: sitiens (sit; a strongly ABA-deficient mutant) and sp12 (a transgenic line that constitutively over-accumulates ABA). The water potential inducing 50% embolism was 0.25 MPa lower in sp12 than in sit. Maximum stomatal and minimum leaf conductances were considerably lower in plants with higher ABA biosynthesis (WT and sp12). Variations in gas exchange were associated with both ABA levels and differences in stomatal density and size. Plants with higher ABA biosynthesis exhibited lower water loss, delaying lethal water potentials associated with embolism during drought. In conclusion, ABA does not impact xylem embolism resistance; instead, its primary mechanism for enhancing drought tolerance involves reducing water loss, thus delaying dehydration and hydraulic dysfunction.https://cassyni-user-files-prod.s3.amazonaws.com/WBRPJVqV2pgTnaMKGL2rLv https://cassyni.com/events/RfSG5DecVBBbQNeLNv4egD/seminar/qa https://cassyni.com/slides/outline/RfSG5DecVBBbQNeLNv4egD https://cassyni.com/events/RfSG5DecVBBbQNeLNv4egD/abstract https://cassyni-user-files-prod.s3.amazonaws.com/BKjFjgXgiwdjz9tSfx8xg6 https://cassyni.com/events/RfSG5DecVBBbQNeLNv4egD?videoPreview=1 Exploring transport and selectivity in salt-rejecting membranes using transition-state theorynohttps://cassyni.com/events/RfSG5DecVBBbQNeLNv4egD?videoPreview=12024-10-10T09:00:00+00:004322.04ElsevierSalt-rejecting membranes have been widely implemented in water purification and desalination processes. Separation between species at the molecular level is achievable in these membranes due to complex and poorly understood set of transport mechanisms that have attracted the attention of researchers within and beyond the membrane community for many years. Minimizing existing knowledge gaps in transport through salt-rejecting membranes can improve the sustainability of current water-treatment processes and expand the use of these membranes to other applications that require high selectivity between species. Since its establishment in 1949, Eyring’s transition-state theory (TST) for transmembrane permeation has been applied in numerous studies to mechanistically explore molecular transport in dense membranes, such as nanofiltration (NF) and reverse osmosis (RO) membranes. In this presentation, I will first discuss the limited ability of commonly used transport models to mechanistically explain transport and selectivity trends observed in NF and RO membranes. Next, I will introduce the underlying principles and equations of TST and establish the connection to transmembrane permeation with a focus on molecular-level enthalpic and entropic barriers that govern water and solute transport under confinement. I will then highlight mechanistic insights into transport in NF and RO membranes that can be gained by analyzing enthalpic and entropic activation barriers that were measured under different conditions. I will also discuss major limitations of the experimental application of TST and propose specific solutions to minimize the uncertainties surrounding the current approach. https://cassyni-user-files-prod.s3.amazonaws.com/BKjFjgXgiwdjz9tSfx8xg6 https://cassyni.com/slides/outline/6Q9hGZR9NKaidnbqTcULz1 https://cassyni.com/events/6Q9hGZR9NKaidnbqTcULz1/abstract https://cassyni-user-files-prod.s3.amazonaws.com/k7V7uLSoPhjA9j2N8Rzgv https://cassyni.com/events/6Q9hGZR9NKaidnbqTcULz1?videoPreview=1 More allogrooming is followed by higher physiological stress in wild female baboonsnohttps://cassyni.com/events/6Q9hGZR9NKaidnbqTcULz1?videoPreview=12024-08-30T12:00:00+00:001419.68Royal Society PublishingSocial bonds increase fitness in a range of mammals. One potential pathway by which social bonds increase fitness is by reducing the exposure to physiological stress, i.e., glucocorticoid (GC) hormones, that can be detrimental to health and survival. This is achieved through downregulating hypothalamic-pituitary-adrenal (HPA)-axis activity. While long-term measures of social (grooming) bonds are often negatively correlated with HPA-axis activity, the proximate role of physical touch through allogrooming remains an open question in the sociality-health-fitness debate. Demonstrating potential anxiolytic benefits of grooming in the wild is hindered by methodological limitations. Here, we match accelerometer-identified grooming in wild female chacma baboons (Papio ursinus) to non-invasive faecal GC concentrations (fGCs). Consistent with previous work, we found a negative overall correlation between individual averaged fGCs and grooming rates. However, when time-matching grooming to fGCs, we found both more giving and receiving grooming was followed by higher fGCs. This upregulation of HPA-axis activity suggests that maintaining social bonds and its associated fitness benefits, may come at a shorter-term physiological cost. This finding sheds new light on a ubiquitous social behaviour typically considered ‘relaxing’ and suggests sociopositive contact can trigger physiological stress.https://cassyni-user-files-prod.s3.amazonaws.com/k7V7uLSoPhjA9j2N8Rzgv https://cassyni.com/events/8sPiVyemZcMCzj5Q1JNyhw/abstract https://cassyni-user-files-prod.s3.amazonaws.com/zSHeFAD27ypfs8oXzuzEz https://cassyni.com/events/Tfeoiwtyk3hEgtVT8mMFs/seminar/qa https://cassyni.com/slides/outline/Tfeoiwtyk3hEgtVT8mMFs https://cassyni.com/events/Tfeoiwtyk3hEgtVT8mMFs/abstract https://cassyni-user-files-prod.s3.amazonaws.com/RLmwr8WuYq6k6f6BVGNQ3x https://cassyni.com/events/Tfeoiwtyk3hEgtVT8mMFs?videoPreview=1 Reinforcement Learning in Building Energy Management: Challenges and Future Directionsnohttps://cassyni.com/events/Tfeoiwtyk3hEgtVT8mMFs?videoPreview=12024-07-17T13:30:00+00:003630.48Data-Centric Engineering JournalBuildings account for approximately 40% of global energy consumption and associated greenhouse gas emissions, highlighting their critical role in grid decarbonization. The integration of fluctuating renewable energy sources adds significant uncertainties, requiring adaptive energy use in buildings for grid resilience. This adaptation entails a shift from passive consumption to active participation in the energy grid, ensuring demand flexibility and occupant comfort without compromising energy efficiency. Reinforcement Learning (RL) has emerged as a prominent approach to meet these challenges in building energy management. This presentation examines key questions pertaining to the application of RL in flexible energy management of buildings. It covers the impacts of increasing data availability, advancements in machine learning algorithms, the importance of open-source tools, and the practical aspects of software and hardware integration for effective RL implementation. The presentation aims to provide a succinct introduction to RL in the context of building energy management, offering an overview of current research, pinpointing challenges, and highlighting opportunities for future research directions.https://cassyni-user-files-prod.s3.amazonaws.com/RLmwr8WuYq6k6f6BVGNQ3x https://cassyni.com/slides/outline/3vug39BXB2pBbdN3zpfyyo https://cassyni.com/events/3vug39BXB2pBbdN3zpfyyo/abstract https://cassyni-user-files-prod.s3.amazonaws.com/2MvVRktrMDPtvc78v9oP9g https://cassyni.com/events/3vug39BXB2pBbdN3zpfyyo?videoPreview=1 The functions of leg muscles, structures and mechanisms in runningnohttps://cassyni.com/events/3vug39BXB2pBbdN3zpfyyo?videoPreview=12024-07-12T12:00:00+00:001019.0Royal Society PublishingThe actions of the major human leg muscles are well established; however, the functions of these muscle actions during steady running remain unclear. Here, leg structures and mechanisms are considered in terms of their functions in meeting the task of a vehicle acting as an effective machine – in supporting body weight during translation with low mechanical work demand, and in supplying mechanical work economically. Legs are modelled as a sequence of linkages that predict muscle actions and reveal the varying muscle functions within the integrated leg. Work avoidance is achieved with isometric muscles and linkages that promote a sliding of the hip over the ground contact, resulting in an approximately horizontal path of the centre of mass. Economical work supply requires, for muscle with constrained power, shortening over the entire stance duration; this function is achieved by the hamstrings without disrupting the linkages resulting in work avoidance. In late stance, the two functions occur through coactivation of antagonistic muscles, providing one answer to Lombard’s paradox. Quadriceps and hamstring tensions result in opposing moments about both hip and knee joints, but by doing so perform the independent yet complementary roles of work avoidance during translating weight support and economical work supply. https://cassyni-user-files-prod.s3.amazonaws.com/2MvVRktrMDPtvc78v9oP9g https://cassyni.com/slides/outline/GH7nCEMe9Uf3VJbryBEi7w https://cassyni.com/events/GH7nCEMe9Uf3VJbryBEi7w/abstract https://cassyni-user-files-prod.s3.amazonaws.com/F4Xy1it9pLj8KpffRsxk6z https://cassyni.com/events/GH7nCEMe9Uf3VJbryBEi7w?videoPreview=1 Law invariance and Ordernohttps://cassyni.com/events/GH7nCEMe9Uf3VJbryBEi7w?videoPreview=12021-04-22T14:00:00+00:003418.08Positivity Journal, SpringerNatureLet $\mathcal{X}$ be an r.i. space over a non-atomic probability space. Let $\rho:\mathcal{X}\rightarrow(-\infty,\infty] $ be proper, convex, and increasing. It is known that order lower semicontinuity does not imply $\sigma(\mathcal{X},\mathcal{X}_n^sim)$ lower semicontinuity. However, if $\rho$ is additionally law invariant, then the implication does hold. This result indicates an interplay between law invariance and order. More surprisingly, we show that if $\rho$ is real-valued and law invariant, then both order and $\sigma(\mathcal{X},\mathcal{X}_n^\sim)$ lower semicontinuity is automatic at every $X\in\mathcal{X}$ such that $X^-\in\mathcal{X}^a$.https://cassyni-user-files-prod.s3.amazonaws.com/F4Xy1it9pLj8KpffRsxk6z https://cassyni.com/events/JFjpVbTdJfoXjVaVci36B7/seminar/qa https://cassyni.com/slides/outline/JFjpVbTdJfoXjVaVci36B7 https://cassyni.com/events/JFjpVbTdJfoXjVaVci36B7/abstract https://cassyni-user-files-prod.s3.amazonaws.com/7qPc1Z9uiyr5Jr3K6coMyY https://cassyni.com/events/JFjpVbTdJfoXjVaVci36B7?videoPreview=1 The Future of Peer Reviewnohttps://cassyni.com/events/JFjpVbTdJfoXjVaVci36B7?videoPreview=12024-09-25T14:00:00+00:003038.0Topics at the heart of our communityAs part of a Peer Review Week special, join Markus Kaindl, Director of Content Innovation, a Springer Nature expert on AI supported solutions, and Stavroula Kousta, Chief Editor of Nature Human Behaviour, in conversation, as they share their expertise and experiences on the vital role of peer review and how AI might shape its future. https://cassyni-user-files-prod.s3.amazonaws.com/7qPc1Z9uiyr5Jr3K6coMyY https://cassyni.com/events/V817WdhAxjz1FmQXEFGn7w/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Lz7abKKrqT4YjiUXT8d4ke https://cassyni.com/slides/outline/6tpvRsaZD94YTFbMFibKAD https://cassyni.com/events/6tpvRsaZD94YTFbMFibKAD/abstract https://cassyni-user-files-prod.s3.amazonaws.com/JNRp7wMPNUrDn7nj7f2KyY https://cassyni.com/events/6tpvRsaZD94YTFbMFibKAD?videoPreview=1 Microbiota links to neural dynamics supporting threat processingnohttps://cassyni.com/events/6tpvRsaZD94YTFbMFibKAD?videoPreview=12021-11-09T10:00:00+00:0064.6Microbiome Virtual International Forum There is growing recognition that the composition of the gut microbiota influences behaviour, including responses to threat. The cognitive-interoceptive appraisal of threat-related stimuli relies on dynamic neural computations between the anterior insular (AIC) and the dorsal anterior cingulate (dACC) cortices. If, to what extent, and how microbial consortia influence the activity of this cortical threat processing circuitry is unclear. We addressed this question by combining a threat processing task, neuroimaging, 16S rRNA profiling, and computational modelling in healthy participants. Results showed interactions between high-level ecological indices with threat-related AIC-dACC neural dynamics. At finer taxonomic resolutions, the abundance of Ruminococcus was differentially linked to connectivity between, and activity within the AIC and dACC during threat updating. Functional inference analysis provides a strong rationale to motivate future investigations of microbiota-derived metabolites in the observed relationship with threat-related brain processes.https://cassyni-user-files-prod.s3.amazonaws.com/JNRp7wMPNUrDn7nj7f2KyY https://cassyni.com/slides/outline/7PUXUZE5ebcbT28Er9t7RX https://cassyni.com/events/7PUXUZE5ebcbT28Er9t7RX/abstract https://cassyni-user-files-prod.s3.amazonaws.com/UqhHBU2RwybPAczMKyD5z6 https://cassyni.com/events/7PUXUZE5ebcbT28Er9t7RX?videoPreview=1 Host microbiome interactions in health and diseasenohttps://cassyni.com/events/7PUXUZE5ebcbT28Er9t7RX?videoPreview=12022-01-11T11:00:00+00:001740.04Microbiome Virtual International Forum No abstracthttps://cassyni-user-files-prod.s3.amazonaws.com/UqhHBU2RwybPAczMKyD5z6 https://cassyni.com/events/xLsy37JpZXX49t1FEtKS5/abstract https://cassyni-user-files-prod.s3.amazonaws.com/9jDrP878hmoTz8vdk6Yb6n https://cassyni.com/events/xLsy37JpZXX49t1FEtKS5?videoPreview=1 How heavy metals influence bacterial and fungal alpha-diversity in soil, sediment, and rhizosphere: A meta-analysisnohttps://cassyni.com/events/xLsy37JpZXX49t1FEtKS5?videoPreview=12022-03-08T10:00:00+00:00612.0Microbiome Virtual International Forum Heavy metals (HMs) accumulation in soil affects plant growth and reduces the soil fauna diversity. Contrarily, the effect of HMs on microbial alpha-diversity remains an open question. Literature is contrasting, most likely because the microbial alpha-diversity variations strongly depend on heterogeneous and study-specific experimental conditions (e.g. soil type, soil chemical, physical and biological characteristics, type of metal considered, dose added etc.). Here, we report the first meta-analysis upon the response of soil microbial alpha-diversity to the experimental addition of cadmium (Cd) and copper (Cu). We considered the studies using the DNA metabarcoding of bacterial and fungal communities conducted between 2013 and 2021 to overcome some limitations of other techniques such as Denaturing Gradient Gel Electrophoresis (DGGE), or cultivation. This resulted in 66 independent experiments reported in 32 primary papers located over four continents. We found dose-dependent response to HMs for microbial alpha-diversity in bulk soil, rhizosphere soil and sediments. We further estimated that, on average, 17.5 mg kg-1 was the minimum inhibitory dose necessary to register a first significant loss (0.03 %) in microbial alpha-diversity compared to control conditions. However, such decline in alpha-diversity reached a maximum of 14.3 % for HMs additions peaking 5000 mg kg-1, irrespectively of the different experimental conditions. Our results suggest that extreme doses of Cu and Cd are necessary to have a consistent diversity loss, highlighting how the behaviour of microbial communities diverges from macro-organisms.https://cassyni-user-files-prod.s3.amazonaws.com/9jDrP878hmoTz8vdk6Yb6n https://cassyni.com/slides/outline/EJYz88HRo1NNwq7pDbT3aD https://cassyni.com/events/EJYz88HRo1NNwq7pDbT3aD/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Qv8ZSWjdoEtkFxeyNrHWQe https://cassyni.com/events/EJYz88HRo1NNwq7pDbT3aD?videoPreview=1 Two Competing Guilds as a Core Microbiome Signature for Chronic Diseasesnohttps://cassyni.com/events/EJYz88HRo1NNwq7pDbT3aD?videoPreview=12022-06-15T12:00:00+00:00596.0Microbiome Virtual International Forum Gut microbiota may work as an essential organ and its members interact closely with each other and form a higher-level organization called guilds. How such guild-level structure supports the gut microbiota to stably provide essential health-relevant functions to the host remains elusive. With high quality metagenome-assembled genomes as network nodes, here we identified a core microbiome signature made up of two robust competing guilds that together correlate with a wide range of host health conditions. Genomes in these two guilds kept their ecological relationship unchanged despite experiencing profound abundance changes during a 3-month high fiber intervention and 1-year follow-up in patients with type 2 diabetes. The genomes of one guild harbored more genes for plant polysaccharide degradation and butyrate production, while the other guild had more genes for virulence or antibiotic resistance. A Random Forest regression model showed that the abundance distributions of these genomes were associated with 41 out of 43 bio-clinical parameters in the study cohort. With these genomes as reference, Random Forest modeling successfully classified case and control of 8 chronic diseases in 12 independent metagenomic datasets from 1,816 participants across ethnicity and geography. This core microbiome signature49 may facilitate ecological management of chronic diseases.https://cassyni-user-files-prod.s3.amazonaws.com/Qv8ZSWjdoEtkFxeyNrHWQe https://cassyni.com/slides/outline/Gmo1MYX3zJ8sJmbNmHMgJ9 https://cassyni.com/events/Gmo1MYX3zJ8sJmbNmHMgJ9/abstract https://cassyni-user-files-prod.s3.amazonaws.com/3edTpc2fZdN2UUqr2jpPxz https://cassyni.com/events/Gmo1MYX3zJ8sJmbNmHMgJ9?videoPreview=1 Of microbiomes and research integrity: scientific misconduct in microbiology and beyondnohttps://cassyni.com/events/Gmo1MYX3zJ8sJmbNmHMgJ9?videoPreview=12022-10-18T12:00:00+00:001740.04Microbiome Virtual International Forum Science builds upon science. Even after peer-review and publication, science papers could still contain images or other data of concern. If not addressed post-publication, papers containing incorrect or even falsified data could lead to wasted time and money spent by other researchers trying to reproduce those results. Several high-profile science misconduct cases have been described, but many more cases remain undetected. Elisabeth Bik is an image forensics detective with a microbiology background, who left her paid job in industry to search for and report biomedical articles that contain errors or data of concern. She has done a systematic scan of 20,000 papers in 40 journals and found that about 4% of these contained inappropriately duplicated images. In her talk she will discuss her career shift from working in academia and industry on microbiome research to her present work on inappropriately duplicated images and other examples of research misconduct. In addition, she will show how to report scientific papers of concern, and how journals and institutions handle such allegations.https://cassyni-user-files-prod.s3.amazonaws.com/3edTpc2fZdN2UUqr2jpPxz https://cassyni.com/slides/outline/9N4wfHpBQRqMYjQUD7k3r5 https://cassyni.com/events/9N4wfHpBQRqMYjQUD7k3r5/abstract https://cassyni-user-files-prod.s3.amazonaws.com/NhDLjSKmpgPyzyVQgDj2za https://cassyni.com/events/9N4wfHpBQRqMYjQUD7k3r5?videoPreview=1 Effect of the intratumoral microbiota on spatial and cellular heterogeneity in cancernohttps://cassyni.com/events/9N4wfHpBQRqMYjQUD7k3r5?videoPreview=12022-12-14T13:00:00+00:00624.04Microbiome Virtual International Forum The tumour-associated microbiota is an intrinsic component of the tumour microenvironment across human cancer types. Intratumoral host–microbiota studies have so far largely relied on bulk tissue analysis, which obscures the spatial distribution and localized effect of the microbiota within tumours. Here, by applying in situ spatial-profiling technologies and single-cell RNA sequencing to oral squamous cell carcinoma and colorectal cancer, we reveal spatial, cellular and molecular host–microbe interactions. We adapted 10x Visium spatial transcriptomics to determine the identity and in situ location of intratumoral microbial communities within patient tissues. Using GeoMx digital spatial profiling, we show that bacterial communities populate microniches that are less vascularized, highly immuno suppressive and associated with malignant cells with lower levels of Ki-67 as compared to bacteria-negative tumour regions. We developed a single-cell RNA-sequencing method that we name INVADEseq (invasion–adhesion-directed expression sequencing) and, by applying this to patient tumours, identify cell-associated bacteria and the host cells with which they interact, as well as uncovering alterations in transcriptional pathways that are involved in inflammation, metastasis, cell dormancy and DNA repair. Through functional studies, we show that cancer cells that are infected with bacteria invade their surrounding environment as single cells and recruit myeloid cells to bacterial regions. Collectively, our data reveal that the distribution of the microbiota within a tumour is not random; instead, it is highly organized in microniches with immune and epithelial cell functions that promote cancer progression. Link to OA paper: https://www.biorxiv.org/content/10.1101/2022.11.07.515285v1https://cassyni-user-files-prod.s3.amazonaws.com/NhDLjSKmpgPyzyVQgDj2za https://cassyni.com/slides/outline/QBYhARjoyXNRwppF1j9rLm https://cassyni.com/events/QBYhARjoyXNRwppF1j9rLm/abstract https://cassyni-user-files-prod.s3.amazonaws.com/P4RKNeuZ8AYk6xmtszoxEr https://cassyni.com/events/QBYhARjoyXNRwppF1j9rLm?videoPreview=1 Ethical and rigorous human microbiome science requires radical interdisciplinary co-laborationnohttps://cassyni.com/events/QBYhARjoyXNRwppF1j9rLm?videoPreview=12024-05-21T14:00:00+00:001032.0Microbiome Virtual International Forum Current human microbiome science is still marked by a European and North American bias with many important ethical implications on the horizon. In addition, the limited research on other understudied populations is not without its ethical quandaries either. In this presentation, I discuss and clarify these ethical issues by disentangling these into 3 main subsets: European and North American bias, cultural insensitivity, and lack of meaningful collaboration and inclusion. Thereafter, I propose an overall approach to solving these quandaries by introducing the notion of radical interdisciplinary co-laboration, in which different academic and non-academic stakeholders mediate their knowledges and labor together in studying human microbiomes. I will elicit how the proposed approach will render microbiome science more ethical and at the same time render the very science of microbiomes more precise and rigorous.https://cassyni-user-files-prod.s3.amazonaws.com/P4RKNeuZ8AYk6xmtszoxEr https://cassyni.com/slides/outline/JkR3eud39VHMYxa1QpA4MK https://cassyni.com/events/JkR3eud39VHMYxa1QpA4MK/abstract https://cassyni-user-files-prod.s3.amazonaws.com/9EEmxtGyRz8eYWXAvEGmJE https://cassyni.com/events/JkR3eud39VHMYxa1QpA4MK?videoPreview=1 Personalized Clostridioides difficile engraftment risk prediction and probiotic therapy assessment in the human gutnohttps://cassyni.com/events/JkR3eud39VHMYxa1QpA4MK?videoPreview=12023-10-17T14:00:00+00:001219.04Microbiome Virtual International Forum Clostridioides difficile colonizes up to 30-40% of community-dwelling adults without causing disease. C. difficile infections (CDIs) are the leading cause of antibiotic-associated diarrhea in the U.S. and typically develop in individuals following disruption of the gut microbiota due to antibiotic or chemotherapy treatments. Further treatment of CDI with antibiotics is not always effective and can lead to antibiotic resistance and recurrent infections (rCDI). The most effective treatment for rCDI is the reestablishment of an intact microbiota via fecal microbiota transplants (FMTs). However, the success of FMTs has been difficult to generalize because the microbial interactions that prevent engraftment and facilitate the successful clearance of C. difficile are still only partially understood. Here we show how microbial community-scale metabolic models (MCMMs) accurately predicted known instances of C. difficile colonization susceptibility or resistance. MCMMs provide detailed mechanistic insights into the ecological interactions that govern C. difficile engraftment, like cross-feeding or competition involving metabolites like succinate, trehalose, and ornithine, which differ from person to person. Indeed, three distinct C. difficile metabolic niches emerge from our MCMMs, two associated with positive growth rates and one that represents non-growth, which are consistently observed across 14,862 individuals from four independent cohorts. Finally, we show how MCMMs can predict personalized engraftment and C. difficile growth suppression for a probiotic cocktail (VE303) designed to replace FMTs for the treatment rCDI. Overall, this powerful modeling approach predicts personalized C. difficile engraftment risk and can be leveraged to assess probiotic treatment efficacy. MCMMs could be extended to better understand personalized engraftment of other opportunistic bacterial pathogens, beneficial probiotic organisms, or more complex microbial consortia. Link to OA publication: https://www.biorxiv.org/content/10.1101/2023.04.28.538771v2.abstracthttps://cassyni-user-files-prod.s3.amazonaws.com/9EEmxtGyRz8eYWXAvEGmJE https://cassyni.com/slides/outline/KF4ehbGZawqQYj6u1FSrcd https://cassyni.com/events/KF4ehbGZawqQYj6u1FSrcd/abstract https://cassyni-user-files-prod.s3.amazonaws.com/7Nom3KbknX3us3ZigehxWa https://cassyni.com/events/KF4ehbGZawqQYj6u1FSrcd?videoPreview=1 Neuroblastoma is associated with alterations in gut microbiome composition subsequent to maternal microbial seedingnohttps://cassyni.com/events/KF4ehbGZawqQYj6u1FSrcd?videoPreview=12024-01-09T13:00:00+00:00606.0Microbiome Virtual International Forum Neuroblastoma is the most frequent extracranial solid tumour in children, accounting for ~15% of deaths due to cancer in childhood. The most common clinical presentation are abdominal tumours. An altered gut microbiome composition has been linked to multiple cancer types, and reported in murine models of neuroblastoma. However, whether children with neuroblastoma display alterations in gut microbiome composition remains unexplored. Here, we assessed gut microbiome composition by shotgun metagenomic profiling in an observational cross-sectional study on 288 individuals, consisting of patients with a diagnosis of neuroblastoma at disease onset (N=63), healthy controls matching the patients on the main covariates of microbiome composition (N=94), healthy siblings of the patients (N=13), mothers of patients (N=59), and mothers of the controls (N=59). We examined taxonomic and functional microbiome composition and mother-infant strain transmission patterns. Patients with neuroblastoma displayed alterations in gut microbiome composition characterised by reduced microbiome richness, decreased relative abundances of 18 species (including Phocaeicola dorei and Bifidobacterium bifidum), enriched protein fermentation and reduced carbohydrate fermentation potential. Using machine learning, we could successfully discriminate patients from controls (AUC = 82%). Healthy siblings did not display such alterations but resembled the healthy control group. No significant differences in maternal microbiome composition nor mother-to-offspring transmission were detected. Therefore, the alterations in taxonomic and functional gut microbiome composition we described in patients with neuroblastoma, cannot be traced to differential maternal seeding and might arise subsequently. Link to OA paper: https://www.thelancet.com/journals/ebiom/article/PIIS2352-3964(23)00483-8/fulltexthttps://cassyni-user-files-prod.s3.amazonaws.com/7Nom3KbknX3us3ZigehxWa https://cassyni.com/slides/outline/VcgLfwraoZTq5EQ32MPkJ9 https://cassyni.com/events/VcgLfwraoZTq5EQ32MPkJ9/abstract https://cassyni-user-files-prod.s3.amazonaws.com/D4GD5BYHqHRQWAZHs9Rr22 https://cassyni.com/events/VcgLfwraoZTq5EQ32MPkJ9?videoPreview=1 Gut microorganisms and their genes are associated with cognition and neuroanatomy in childrennohttps://cassyni.com/events/VcgLfwraoZTq5EQ32MPkJ9?videoPreview=12023-05-17T14:00:00+00:00616.04Microbiome Virtual International Forum The gastrointestinal tract, its resident microorganisms, and the central nervous system are connected by biochemical signaling, also known as the ”microbiome-gut-brain-axis.” Both the human brain and the gut microbiome have critical developmental windows in the first years of life, raising the possibility that their development is co-occurring and likely co-dependent. Emerging evidence implicates gut microorganisms and microbiota composition in cognitive outcomes and neurodevelopmental disorders (e.g., autism and anxiety), but the influence of gut microbial metabolism on typical neurodevelopment has not been explored in detail. We investigated the relationship of the microbiome with the neuroanatomy and cognitive function of 361 healthy children, demon- strating that differences in gut microbial taxa and gene functions are associated with overall cognitive function and with differences in the size of multiple brain regions. Using a combination of multivariate linear and machine learning (ML) models, we showed that many species, including Gordonibacter pamelae and Blautia wexlerae, were significantly associated with higher cognitive function, while some species such as Ruminococcus gnavus were more commonly found in children with low cognitive scores after controlling for sociodemographic factors. Microbial genes for enzymes involved in the metabolism of neuroactive compounds, particularly short-chain fatty acids such as acetate and propionate, were also associated with cognitive function. In addition, ML models were able to use microbial taxa to predict the volume of brain regions, and many taxa that were identified as important in predicting cognitive function also dominated the feature importance metric for individual brain regions. For example, B. wexlerae was the most important species in models predicting the size of the parahippocampal region in both the left and right hemispheres, while several species from the phylum Bacteroidetes, including GABA-producing B. ovatus, were important for predicting the size of the left accumbens area, but not the right. These findings provide potential biomarkers of neurocognition and brain development and may lead to the future development of targets for early detection and early intervention. Link to OA paper: https://doi.org/10.1101/2020.02.13.944181https://cassyni-user-files-prod.s3.amazonaws.com/D4GD5BYHqHRQWAZHs9Rr22 https://cassyni.com/slides/outline/5QujQT9sJ8KvuYeC6a6Sso https://cassyni.com/events/5QujQT9sJ8KvuYeC6a6Sso/abstract https://cassyni-user-files-prod.s3.amazonaws.com/858uxNU3vkHXiPcPYktiDU https://cassyni.com/events/5QujQT9sJ8KvuYeC6a6Sso?videoPreview=1 How much training is enough? Evaluating clinician self-reported family violence response skills following a 3-year transformational change project in a major trauma hospitalnohttps://cassyni.com/events/5QujQT9sJ8KvuYeC6a6Sso?videoPreview=12024-10-08T12:00:00+00:00755.16Women's HealthRates of family violence are high in many societies, with disproportionate impacts on women and children. Healthcare services have an important gateway role for victim-survivors requiring assistance. There is limited evidence regarding how much training is required for hospital clinicians to be adequately prepared to work effectively with clients experiencing family violence. This study aimed to investigate the impact of different levels of training in family violence, on the knowledge and confidence of hospital clinicians. A cross-sectional, online survey of hospital clinicians in a major trauma hospital was conducted. The study evaluated the impact of level of family violence training (no training, some training, clinical champions), on staff self-reported family violence knowledge and confidence levels. The Royal Melbourne Hospital Clinician Survey tool was utilised, and open for clinicians to complete, anonymously over a six-week period. 526 clinical staff participated across a range of profession groups (Allied Health, 47%; Nursing 40%; Medical 13%). Staff with some training (mean training hours 3.25, SD 5.23) rated their knowledge and confidence levels at least two-thirds higher than those with no training Those trained as clinical champions (mean training hours 14.60, SD 9.14), rated their knowledge and confidence at least 50 percent higher than staff with some training. An even more pronounced elevation across training levels was seen with specific family violence clinical skills – identifying the signs of family violence, knowing how to screen patients, and providing an appropriate response to disclosures. Training in family violence clinical response significantly increased self-reported knowledge and confidence levels of hospital staff, with the extra time and resourcing required to train clinical champions, showing clear benefits. The provision of evidence-based and well-resourced family violence education for healthcare professionals is required to drive clinical practice improvements for victim-survivors. https://cassyni-user-files-prod.s3.amazonaws.com/858uxNU3vkHXiPcPYktiDU https://cassyni.com/slides/outline/Y5e8m4wLyEy6ecfodTogz9 https://cassyni.com/events/Y5e8m4wLyEy6ecfodTogz9/abstract https://cassyni-user-files-prod.s3.amazonaws.com/HJWYREH65rcVBbetcSuTAW https://cassyni.com/events/Y5e8m4wLyEy6ecfodTogz9?videoPreview=1 Strange Nonchaotic Attractor in a Self-organized Turbulent Reactive Flow Systemnohttps://cassyni.com/events/Y5e8m4wLyEy6ecfodTogz9?videoPreview=12025-06-24T10:00:00+00:00740.32NODYSStrange nonchaotic attractor (SNA) is an exotic state typically observed in dynamical systems subjected to external quasiperiodic or periodic forcing. In this study, we discover the state of SNA in a self-organized turbulent reactive flow system. We observe the state of SNA prior to the emergence of periodic oscillations. We use the 0-1 test and correlation dimension analysis to characterize this state, followed by a singular continuous spectrum to confirm its classification as SNA. The system is inherently complex, and a state of chaos is expected owing to its nonlinearity. Order emerges due to self-organization. However, the emergence of SNA is nonintuitive.https://cassyni-user-files-prod.s3.amazonaws.com/HJWYREH65rcVBbetcSuTAW https://cassyni.com/slides/outline/SeWVFYpa9Ct2FkRa2Yotzh https://cassyni.com/events/SeWVFYpa9Ct2FkRa2Yotzh/abstract https://cassyni-user-files-prod.s3.amazonaws.com/LWiyDfyzwLDAjEqLqYUbz6 https://cassyni.com/events/SeWVFYpa9Ct2FkRa2Yotzh?videoPreview=1 Chatter in Dynamic Scanning Probe Lithography (d-SPL)nohttps://cassyni.com/events/SeWVFYpa9Ct2FkRa2Yotzh?videoPreview=12025-06-24T10:00:00+00:00744.4NODYSScanning probe lithography (SPL) techniques are pushing the boundaries of nano- to micro-scale fabrication. Though often requires a trade-off between throughput and resolution. In this study, we introduce dynamic scanning Probe Lithography (d-SPL), a high-throughput method that enables direct surface patterning in the feature range of nanometer to centimeter. Using d-SPL, we achieved a 1 cm-long, 100 nm-thick, 2 µm-wide channel in less than 10 seconds, showcasing major gains in speed and resolution. We also developed and validated an analytical model to explain and reproduce micro-scale chatter that was observed for the first time in micro-scale fabrication. Our model was able to map the stable and unstable regions corresponding to uniform and non-uniform (damaged) surface patterns.https://cassyni-user-files-prod.s3.amazonaws.com/LWiyDfyzwLDAjEqLqYUbz6 https://cassyni.com/slides/outline/T9A6JEU6afS5FWxTcz6hG1 https://cassyni.com/events/T9A6JEU6afS5FWxTcz6hG1/abstract https://cassyni-user-files-prod.s3.amazonaws.com/EqJ9JSZMHvn6NyNUR6ivdC https://cassyni.com/events/T9A6JEU6afS5FWxTcz6hG1?videoPreview=1 Limit cycle oscillation of Nitinol embedded laminate beam: Experimental insight into geometric and material nonlinearitynohttps://cassyni.com/events/T9A6JEU6afS5FWxTcz6hG1?videoPreview=12025-06-24T10:00:00+00:00595.2NODYSThis study examines the nonlinear aeroelastic behavior of Glass Fiber Reinforced Polymer (GFRP) composite laminates and hybrid composites with Shape Memory Alloy (SMA) Nitinol wires through numerical analysis and wind tunnel testing. Significant nonlinearity and limit cycle oscillations (LCO) were observed in a six-layer GFRP specimen at wind velocities of 20-30 m/s, validated by image processing and accelerometer data. This is perhaps the first time a mechanical system is reported to undergo LCO, which is observed in Van der Pol oscillator.https://cassyni-user-files-prod.s3.amazonaws.com/EqJ9JSZMHvn6NyNUR6ivdC https://cassyni.com/slides/outline/5uH7JqeXhycm7kyHkRtZ7B https://cassyni.com/events/5uH7JqeXhycm7kyHkRtZ7B/abstract https://cassyni-user-files-prod.s3.amazonaws.com/CcNvbN9VKNHhXkJh3HJHTL https://cassyni.com/events/5uH7JqeXhycm7kyHkRtZ7B?videoPreview=1 Analysis of epidemic dynamics: Incorporating PRCC in SIRS model with control strategies and environmental fluctuationsnohttps://cassyni.com/events/5uH7JqeXhycm7kyHkRtZ7B?videoPreview=12025-06-24T11:00:00+00:00586.48NODYSThe present article examines the global characteristics of a generalized SIHRS (susceptible-infected-hospitalized-recovered-susceptible) epidemic model. This investigation incorporates the influence of government policies, public responses, and social behavioral reactions. We also analyze how environmental fluctuations and time-dependent control strategies affect the dynamics of disease spread. For deterministic model, these findings indicate that the disease will spread within the population if basic reproduction number exceeds 1. Sensitivity analysis is employed using Latin hypercube sampling method to evaluate the impact of model parameters on disease spread. Subsequently, Kendall’s tau and Spearman’s rank correlation coefficients are computed to gain deeper insights. The findings indicate that early government action during a disease outbreak effectively accelerates the occurrence of a disease-free state. Additionally, a crucial finding of this study is that random fluctuations can help to prevent disease outbreaks, paving the way for effective control techniques to manage disease dynamics. The combination of governmental actions and total number of hospital beds proves to be an effective control strategy in this model. Our results show that implementing these strategies significantly reduces the disease burden.https://cassyni-user-files-prod.s3.amazonaws.com/CcNvbN9VKNHhXkJh3HJHTL https://cassyni.com/slides/outline/DogQAQWp8fQRRoVGWQsFhP https://cassyni.com/events/DogQAQWp8fQRRoVGWQsFhP/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Y6SqsQoEpwLP36bnJEj2vz https://cassyni.com/events/DogQAQWp8fQRRoVGWQsFhP?videoPreview=1 Advancing the Magnetic Mirror with Theory and Integrated Modeling at Realta Fusionnohttps://cassyni.com/events/DogQAQWp8fQRRoVGWQsFhP?videoPreview=12025-07-10T15:00:00+00:003128.2Journal of Plasma PhysicsThe magnetic mirror is a simple, open-ended, fusion concept that could potentially form the basis of an attractive fusion power plant. While the magnetic mirror saw substantial development throughout the 20th century, development of the concept slowed significantly after the 1980s. Realta Fusion is a private fusion company working to commercialize the mirror and was spun out of the Wisconsin High-Temperature-Superconducting (HTS) Axisymmetric Mirror (WHAM) project at the University of Wisconsin-Madison. Realta Fusion is developing the axisymmetric magnetic mirror concept with HTS magnets, new stability control mechanisms, and advanced computing. In this talk, we will discuss the theory and modelling activities underway at Realta Fusion. This will include integrated heating, transport, and equilibrium modeling in support of the WHAM experiment and for the design of the next step device Anvil as well as confinement performance predictions for the fusion pilot plant concept Hammir.https://cassyni-user-files-prod.s3.amazonaws.com/Y6SqsQoEpwLP36bnJEj2vz https://cassyni.com/slides/outline/AM9Aqcz94TXnQ7BhrkVJAZ https://cassyni.com/events/AM9Aqcz94TXnQ7BhrkVJAZ/abstract https://cassyni-user-files-prod.s3.amazonaws.com/SudztEWEDdXJoWEt2zRmw4 https://cassyni.com/events/AM9Aqcz94TXnQ7BhrkVJAZ?videoPreview=1 The effects of finite electron inertia on helicity-barrier-mediated turbulencenohttps://cassyni.com/events/AM9Aqcz94TXnQ7BhrkVJAZ?videoPreview=12024-05-30T15:00:00+00:002777.36Journal of Plasma PhysicsUnderstanding the partitioning of turbulent energy between ions and electrons in weakly collisional plasmas is crucial for the accurate interpretation of observations and modelling of various astrophysical phenomena. Many such plasmas are “imbalanced”, wherein the large-scale energy input is dominated by Alfvénic fluctuations propagating in a single direction. In this talk, we demonstrate that when strongly-magnetised plasma turbulence is imbalanced, nonlinear conservation laws imply the existence of a critical value of the electron plasma beta (the ratio of the thermal to magnetic pressures) that separates two dramatically different types of turbulence in parameter space. For betas below the critical value, the free energy injected on the largest scales is able to undergo a familiar Kolmogorov-type cascade to small scales where it is dissipated, heating electrons. For betas above the critical value, the system forms a “helicity barrier” that prevents the cascade from proceeding past the ion Larmor radius, causing the majority of the injected free energy to be deposited into ion heating. Physically, the helicity barrier results from the inability of the system to adjust to the disparity between the perpendicular-wavenumber scalings of the free energy and generalised helicity below the ion Larmor radius; restoring finite electron inertia can annul, or even reverse, this disparity, giving rise to the aforementioned critical beta. We relate this physics to the “dynamic phase alignment” mechanism (that operates under yet lower beta conditions and in pair plasmas), and characterise various other important features of the helicity barrier, including the nature of the nonlinear wavenumber-space fluxes, dissipation rates, and energy spectra. The existence of such a critical beta has important implications for heating, as it suggests that the dominant recipient of the turbulent energy — ions or electrons — can depend sensitively on the characteristics of the plasma at large scales.https://cassyni-user-files-prod.s3.amazonaws.com/SudztEWEDdXJoWEt2zRmw4 https://cassyni.com/slides/outline/CpPC53DmFkJGm3fGQSPvtV https://cassyni.com/events/CpPC53DmFkJGm3fGQSPvtV/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Miq9u4DDcKhuqNYRN2tQyC https://cassyni.com/events/CpPC53DmFkJGm3fGQSPvtV?videoPreview=1 Identification of new MHD mechanisms responsible for plasma performance-setting in tokamaks and the use of analytic theory for informing and improving numerical modelsnohttps://cassyni.com/events/CpPC53DmFkJGm3fGQSPvtV?videoPreview=12024-12-12T16:00:00+00:003192.52Journal of Plasma PhysicsTokamak plasma performance is significantly limited by long-wavelength MHD instabilities. Despite these modes being a necessary condition for good plasma operation, they are subtle, leading to mistakes being made in both analytical and numerical approaches to their modelling. For pressure driven instabilities, the stabilising role of ordinarily dominant effects such as magnetic field line bending and compression are typically very small, and as such, many apparently weak effects are critical. It is for this reason that realistic geometry, as defined by the boundary conditions of the laboratory plasma, finite beta effects, equilibrium flows, and kinetic corrections typically determines plasma stability. This presentation documents the role that analytic theory plays in understanding linear and nonlinear MHD instabilities, and in informing codes of their errors, and advising improved models. Alternative calculations of nonlinearly saturated instabilities are presented, and their virtues and applications are compared. Showcased are the effects of parallel magnetic field fluctuations, centrifugal corrections associated with strong toroidal flows, and the continuum damping of internal kink modes and Kelvin Helmholtz-like modes due to respectively zonal and geodesic acoustic modes. Finally, after the review of the aforementioned topics, a model will be presented which is consistent with tokamak hybrid scenarios where the plasma ceases to diffuse over resistive confinement timescales. An ideal nonlinear MHD model is offered as an alternative to the flux pump hypothesis which has recently excited some in the magnetic fusion community for enabling high-performance sawtooth-avoiding plasma operation.https://cassyni-user-files-prod.s3.amazonaws.com/Miq9u4DDcKhuqNYRN2tQyC https://cassyni.com/slides/outline/MDS5yHja7tdz4ri8krfRk1 https://cassyni.com/events/MDS5yHja7tdz4ri8krfRk1/abstract https://cassyni-user-files-prod.s3.amazonaws.com/QMDVEB4r9K5VnoLE5eZqUr https://cassyni.com/events/MDS5yHja7tdz4ri8krfRk1?videoPreview=1 Electron acceleration by a two stage laser-plasma interactionnohttps://cassyni.com/events/MDS5yHja7tdz4ri8krfRk1?videoPreview=12023-08-31T15:00:00+00:001937.76Journal of Plasma PhysicsUltraintense, short pulsed lasers with high contrast allow the exploration of new mechanisms for particle acceleration. In particular, when such lasers irradiate an overdense plasma, electromagnetic waves appear at the vacuum-plasma interface, enabling local field confinement and enhancement. Since these mechanisms involve an overdense plasma, high values of total electron beam charge (~nC) can be achieved, which is important for applications in the fields of plasma-based accelerators, electron sources, among others. Recent Particle-in-Cell (PIC) simulations analyzed a laser pulse interacting with the wedge of an overdense plasma, and showed that it produces a diffracted electromagnetic wave with an intense longitudinal electric field that efficiently accelerates collimated electron bunches with high charge (~nC) and relativistic energies up to ~130 MeV. In this talk, I will present a new scheme which couples electron acceleration in an overdense plasma with the wakefield produced by the laser propagating through an underdense plasma. Highly charged electron bunches are emitted from the overdense plasma, and trapped by the wakefield in which they are accelerated even further. Such a scheme enables us to obtain highly charged and highly energetic electron bunches at the end of the second acceleration stage.https://cassyni-user-files-prod.s3.amazonaws.com/QMDVEB4r9K5VnoLE5eZqUr https://cassyni.com/slides/outline/Pgg7ChyCKBQURoBhJYa4Tw https://cassyni.com/events/Pgg7ChyCKBQURoBhJYa4Tw/abstract https://cassyni-user-files-prod.s3.amazonaws.com/QginBA6NF52YYX5KLMsJWz https://cassyni.com/events/Pgg7ChyCKBQURoBhJYa4Tw?videoPreview=1 Primordial magnetic fieldsnohttps://cassyni.com/events/Pgg7ChyCKBQURoBhJYa4Tw?videoPreview=12022-03-24T15:00:00+00:003104.08Journal of Plasma PhysicsUntil the late 1980s, primordial magnetic fields were frequently invoked as an alternative to dynamo theory for explaining the galactic magnetic field. Nowadays, dynamo theory is generally accepted, but primordial magnetic fields might still exist, and could permeate the entire Universe - even in the voids of galaxy clusters. The field strength today could be in the range of 1e-16 to 1e-9 Gauss at a reference scale of 1 Mpc. The lower limit is motivated by the non-observation of secondary GeV photons from TeV blazars, although plasma instabilities may provide an alternative explanation for the non-observation.https://cassyni-user-files-prod.s3.amazonaws.com/QginBA6NF52YYX5KLMsJWz https://cassyni.com/events/LE8ssvSXEyXqQ6t8etC6w7/abstract https://cassyni-user-files-prod.s3.amazonaws.com/KFb8fdybR2wRUS4rpLynFG https://cassyni.com/events/WbkZrH2YTbAFvcBGfz8zcd/abstract https://cassyni.com/events/X6QAtxg4u3iJvNiAGRRnsw/abstract https://cassyni-user-files-prod.s3.amazonaws.com/GHPf8cRhMKSFuQ9CiERABg https://cassyni.com/events/RfGXPSZJ51dEXWTvfWRztV/abstract https://cassyni.com/events/6PyxanKpxA2MkvRRkCqhCH/abstract https://cassyni.com/slides/outline/8sDypCZT9Snr7rtzHtkKvD https://cassyni.com/events/8sDypCZT9Snr7rtzHtkKvD/abstract https://cassyni-user-files-prod.s3.amazonaws.com/AFjtB983QbcV8rvXaRgK9G https://cassyni.com/events/8sDypCZT9Snr7rtzHtkKvD?videoPreview=1 PIC simulations of the magnetorotational instability (MRI) in stratified, collisionless accretion disksnohttps://cassyni.com/events/8sDypCZT9Snr7rtzHtkKvD?videoPreview=12023-02-09T16:00:00+00:003396.96Journal of Plasma PhysicsPlasma accretion onto astrophysical compact objects, such as black holes and neutron stars, is often considered to occur in the collisionless regime. This implies that kinetic plasma processes may play a crucial role in the physics of accretion in these systems, giving rise to important phenomena like non-thermal particle acceleration, temperature anisotropies and different temperatures between ions and electrons. Kinetic simulations, beyond MHD modeling, are thus needed in order to acquire a fully self-consistent picture of the processes that participate in disk accretion and to predict their observational signatures. In this talk, we will first present our initial results of 2D and 3D fully kinetic, particle-in-cell (PIC) plasma simulations of the collisionless magnetorotational instability (MRI), an MHD-scale instability that is crucial to produce outward transport of angular momentum in accretion disks. Our simulations are local and stratified, which means that we use the shearing box approximation and self-consistently include the vertical stratification of the disk. We find that the MRI saturation and the transport of angular momentum in our stratified simulations are more efficient than in the case where disk stratification is not included. Particle acceleration in our runs is efficient and mainly driven by magnetic reconnection, and is also more significant when the simulations include stratification. In the final part of the presentation, we will also focus on the non-linear evolution of (microscopic) temperature anisotropy instabilities, which play a crucial role in the MRI evolution by providing an effective collisionality to the plasma. We will show that these instabilities can also contribute to non-thermal particle acceleration in collisionless accretion disks. Our simulation results mainly concentrate on the sub-relativistic plasma regime, relevant for accretion onto black hole systems like Sgr A* and M87.https://cassyni-user-files-prod.s3.amazonaws.com/AFjtB983QbcV8rvXaRgK9G https://cassyni.com/events/9qNfDkjAWZvaANbZJgziGV/abstract https://cassyni-user-files-prod.s3.amazonaws.com/YZXHEfiLLuiDeY47Q3wCU6 https://cassyni.com/slides/outline/BKQLhhDQ32N3d59weqxx2H https://cassyni.com/events/BKQLhhDQ32N3d59weqxx2H/abstract https://cassyni-user-files-prod.s3.amazonaws.com/6vVeYCyjUgr36dR6PM1oT4 https://cassyni.com/events/BKQLhhDQ32N3d59weqxx2H?videoPreview=1 Protein-Losing Enteropathy treatment in congenital heart disease patients: Embolization strategies and long-term outcomesnohttps://cassyni.com/events/BKQLhhDQ32N3d59weqxx2H?videoPreview=12025-10-15T09:50:48+00:00740.0Society for Pediatric Interventional Radiology## Introduction Abnormal hepatic and extra-hepatic lymphatic connections are implicated in protein-losing enteropathy (PLE) in patients with congenital heart disease (CHD) but published reports, focused on intrahepatic lymphatic embolization, show unclear outcomes. ## Materials and Methods We compare the short and long-term outcomes of isolated intrahepatic (IH) versus combined peri-duodenal (IH+PD) embolization through retrospective study of 71 CHD patients who underwent either IH or IH+PD embolization for PLE. The primary endpoint was duration of remission (serum albumin ≥3.0g/dL). Secondary analyses included association with thoracic duct (TD) occlusion, PLE recurrence, and transplant-free survival. ## Results Of 71 patients (17 IH, 54 IH+PD), sustained remission (albumin ≥3 g/dL for ≥1 year) was achieved in 40% (22/54) of IH+PD patients and 11% (2/17) of IH (p=0.04). IH+PD embolization produced higher response within 30 days (86% vs 35%, p<0.0001); in the IH+PD group, median serum albumin levels increased from 2.3g/dL to 4.2g/dL (p<0.0001). PLE recurrence occurred in fewer IH+PD patients (46% vs. 100%; p=0.005) during the follow-up period (median 1.1y, IQR:0.7y–3.5y for IH and 1y, IQR:0.7y–2y for IH+PD). TD occlusion was associated with reduced initial and long-term response, with shorter remission than those without occlusion (p<0.0001). Remission resulted in improved transplant-free survival compared to non-responders or those with recurrence <1 year (p=0.01). Adverse events included transient pancreatitis (75%) and hyperbilirubinemia (40%), largely self-limiting or responsive to conservative management. ## Discussion Extrahepatic lymphatic supply plays an important role in PLE pathogenesis. Combined IH+PD embolization significantly improved response rates, extended duration of remission, and enhanced transplant-free survival compared to IH embolization alone.https://cassyni-user-files-prod.s3.amazonaws.com/6vVeYCyjUgr36dR6PM1oT4 https://cassyni.com/events/Vb96PKWqeiWrzr13aFW7yo/abstract https://cassyni-user-files-prod.s3.amazonaws.com/RGxcoavLsQYjJkByyGchev https://cassyni.com/slides/outline/PBzt3PonUMvecLCBWST6Hj https://cassyni.com/events/PBzt3PonUMvecLCBWST6Hj/abstract https://cassyni-user-files-prod.s3.amazonaws.com/QDx82GvB3rPNkbgVoQirMU https://cassyni.com/events/PBzt3PonUMvecLCBWST6Hj?videoPreview=1 A Computational Approach to Interpret Selectivity and Reactivity in Organo-, Supramolecular, Electrochemical and Photo-redox Catalysisnohttps://cassyni.com/events/PBzt3PonUMvecLCBWST6Hj?videoPreview=12025-06-10T10:00:00+00:003095.12Thieme India ChemTalksEfficient and selective catalysis is predominant in chemistry, enabling the synthesis of molecules and materials with enormous societal and technological impact. Computational chemistry provides a versatile toolbox for studying mechanistic details of catalytic reactions and holds promise to deliver practical strategies to enable the rational in silico catalyst design. Diversity in reactivity, nontrivial electronic structure effects, solvation effects and impact of non-covalent weak dispersive interactions introduce additional complexity that represents a pressing challenge to the conventional synthetic methodologies. Modern in silico tools such as the density functional theory (DFT) and other sophisticated physical techniques assess the energetic landscape quite accurately and provide critical insights on conformational flexibility in predicting stereo-, regio and chemo-selectivity. Herein, we aim to discuss the factors such as non-covalent interactions (NCIs), steric or confinement effects that leads to fascinating transformations through organo-, supramolecular, electrochemical and photo-redox catalysis. In a recent study we predicted the unique role of indole molecules which stabilizes the transition states during the dehydrogenation process of polyfluorinated alcohols, through non-covalent π-π and H-bonding interactions. This study put forth a straightforward protocol to develop biologically relevant fluoroalkyl bis-indoles in a sustainable fashion through in-depth insights gained from extensive DFT predictions. Furthermore, our recent study unfurls the crucial role of NCIs in electrochemical synthesis of unsymmetrically substituted NH-pyrroles from enamines. Trifluoroethanol additives are found to have “magical effect” on tuning oxidation potential of enamines through H-bonding and C-H···π interactions, thus facilitating the desired chemo-selective cross-coupling. Further, we discuss how combined effect of NCIs and removal of steric encumbrance underpin chirality in bifunctional squaramide catalysed reactions leading to skeletal diversity in synthesis of azocine derivatives. Additionally, we also discuss how an electron donor acceptor (EDA) complex promotes visible light mediated (4 + 2) radical annulation between alkyl NHPI esters and N-substituted maleimides. Lastly, we show a supramolecular capsule arrangement of resorcin-arene that facilitates coupling of pyrrole and isocyanates in a solvent-free environment, simply backed by confinement effects.https://cassyni-user-files-prod.s3.amazonaws.com/QDx82GvB3rPNkbgVoQirMU https://cassyni.com/slides/outline/7sRZfVzT231XU51KDVbbBb https://cassyni.com/events/7sRZfVzT231XU51KDVbbBb/abstract https://cassyni-user-files-prod.s3.amazonaws.com/HtebPy3npNTVDpkMosoGNr https://cassyni.com/events/7sRZfVzT231XU51KDVbbBb?videoPreview=1 Topological Metasurfacesnohttps://cassyni.com/events/7sRZfVzT231XU51KDVbbBb?videoPreview=12023-01-10T14:00:00+00:004241.76MetaMATResearch on topological photonics has considerably grown, transferring condensed matter concepts of topological insulators with the discovery of the integer Quantum-Hall effect into the realm of photonics. Today, nanophotonics, which is related to light manipulation with subwavelength objects, offers new opportunities to address light properties. New degrees of freedom in the design of optical components are attained by considering the response of topological nanostructures. So far, optical metasurfaces, made of subwavelength arrangements of nanostructures, have relied on resonant phase scattering occurring in Mie resonators or ultrathin pillars. Full wavefront control requires finding sets of nanostructures that can provide 2π optical phase retardation on the incoming beam. Ultimately, and despite all the efforts in understanding the physical mechanisms leading to optimal designs, including powerful optimization methods, metasurface designs often require witless numerical parameter searches. Relying on symmetry-breaking arguments and topological properties of the associated non-Hermitian matrices representing the metasurfaces, we provide new guidelines for achieving 2π phase coverage in transmission and reflection. This framework allows us to unravel the physical principles underlying Huygens metasurfaces, showing that it exploits degeneracies of transmission- or reflection-matrices Zeros, so-called exceptional points, corresponding to transmissionless and reflectionless states. Overall, symmetry-breaking leading to a displacement of a Zero-Pole pair with its branch cut crossing the real axis, provides a very intuitive design approach for achieving full resonant phase scattering. Encircling EPs and/or zeros in the nanostructure parameter space to provide full 2π-phase are considered, entrusting metasurfaces and flat optics with additional light modulation schemes. Our results explain the importance of topological defects and how they can be manipulated for achieving realistic and insightful metasurface designs.https://cassyni-user-files-prod.s3.amazonaws.com/HtebPy3npNTVDpkMosoGNr https://cassyni.com/slides/outline/Wbe5Pkxzr9TMLzyWVYzZKK https://cassyni.com/events/Wbe5Pkxzr9TMLzyWVYzZKK/abstract https://cassyni-user-files-prod.s3.amazonaws.com/7jeokkDvee3wwQx3djj7Ee https://cassyni.com/slides/outline/BLMWb6jXjHrkdjWM4rkdJm https://cassyni.com/events/BLMWb6jXjHrkdjWM4rkdJm/abstract https://cassyni-user-files-prod.s3.amazonaws.com/9umhMdu7tNxa1tXpc42jWn https://cassyni.com/events/BLMWb6jXjHrkdjWM4rkdJm?videoPreview=1 Exploring the limits of flow measurements over very large volumesnohttps://cassyni.com/events/BLMWb6jXjHrkdjWM4rkdJm?videoPreview=12021-02-01T15:00:00+00:002164.44Experiments in FluidsState-of-the-art flow measurements typically utilize four or more high-speed cameras to perform highly-accurate Lagrangian particle tracking (LPT) over small-to-medium-sized measurement volumes (Schanz et al., 2016). Recently, Hou et al. (2021) proposed a novel LPT approach that allows for measurement over significantly larger measurement volumes on the order of 10m3 while simplifying the experimental setup. Here, a single camera is used to track centimeter-sized soap bubbles in three dimensions by not only evaluating the bubble-center location but also the bubble-image size itself. Possible applications of the suggested approach include – but are not limited to – measurements in industrial wind tunnels (Hou et al., 2021), full-scale measurements in the atmospheric boundary layer (Rosi et al., 2014; Toloui et al., 2014), and the characterization of airflow in indoor spaces, such as offices or classrooms (Kaehler et al., 2020). With such large-scale measurements come challenges associated with identifying characteristic features with inherently sparse data. Existing approaches, including coherent-structure coloring (CSC) – see Schlueter-Kuck & Dabiri (2017)) and Martins et al. (2021) – will be reviewed before a new approach based on multi-scale recurrence networks will be tested on a series of canonical problems.https://cassyni-user-files-prod.s3.amazonaws.com/9umhMdu7tNxa1tXpc42jWn https://cassyni.com/events/MhYrr1bFuVbGxmmcqc1ZHo/abstract https://cassyni-user-files-prod.s3.amazonaws.com/7L9hhMTdDMVEM6qqohrjft https://cassyni.com/slides/outline/3vdStr2f9RYv99yt6ytttm https://cassyni.com/events/3vdStr2f9RYv99yt6ytttm/abstract https://cassyni-user-files-prod.s3.amazonaws.com/G3Vnt45puZfF42i6t6Pjdp https://cassyni.com/events/3vdStr2f9RYv99yt6ytttm?videoPreview=1 Swirl-LM: a TensorFlow simulation framework for scientific computing of fluid flows on tensor processing unitsnohttps://cassyni.com/events/3vdStr2f9RYv99yt6ytttm?videoPreview=12023-01-10T16:00:00+00:003558.2Computer Physics CommunicationsSwirl-LM is an open source computational fluid dynamics (CFD) simulation framework that is developed with the TensorFlow programming paradigm. It solves the variable-density Navier-Stokes equation using a low-Mach approximation, and the governing equations are discretized by a finite-difference method on a collocated structured mesh. This presentation focuses on elaborating the implementation and demonstrating the performance of this framework on the Tensor Processing Unit (TPU) platform. The TPU architecture is featured with accelerated dense matrix multiplication, large high bandwidth memory, and a fast inter-chip interconnect, making it attractive for high-performance scientific computing. In this presentation, the accuracy and performance of this framework is assessed both numerically and analytically, specifically focusing on effects of TPU-native single precision floating point arithmetic. The algorithm and implementation are validated with canonical 2D and 3D Taylor-Green vortex simulations. To demonstrate the capability for simulating turbulent flows, simulations are conducted for two configurations, namely decaying homogeneous isotropic turbulence and a turbulent planar jet. Both simulations show good statistical agreement with reference solutions. The performance analysis shows a linear weak scaling and a superlinear strong scaling up to a full TPU v3 pod with 2048 cores.https://cassyni-user-files-prod.s3.amazonaws.com/G3Vnt45puZfF42i6t6Pjdp https://cassyni.com/slides/outline/JF1dXE4aqHidw5U4Bwdbky https://cassyni.com/events/JF1dXE4aqHidw5U4Bwdbky/abstract https://cassyni-user-files-prod.s3.amazonaws.com/8YxfN8MYH1WCrrn7rV4BLJ https://cassyni.com/events/JF1dXE4aqHidw5U4Bwdbky?videoPreview=1 Utah library updatesnohttps://cassyni.com/events/JF1dXE4aqHidw5U4Bwdbky?videoPreview=12022-09-13T13:15:00+00:00701.28NEKTAR++No abstracthttps://cassyni-user-files-prod.s3.amazonaws.com/8YxfN8MYH1WCrrn7rV4BLJ https://cassyni.com/slides/outline/LiFekeJD2aV8J1wcjdYEUu https://cassyni.com/events/LiFekeJD2aV8J1wcjdYEUu/abstract https://cassyni-user-files-prod.s3.amazonaws.com/725YGXEkmy2terwmwDZ62r https://cassyni.com/events/LiFekeJD2aV8J1wcjdYEUu?videoPreview=1 Water legislation 50 years after the Clean Water Actnohttps://cassyni.com/events/LiFekeJD2aV8J1wcjdYEUu?videoPreview=12022-10-18T15:00:00+00:003684.24Nature WaterOctober 18, 2022, marks the 50th anniversary of the passage of the federal Clean Water Act (CWA) in the United States. To commemorate this anniversary we will explore challenges and impacts of water laws in our age and discuss how these laws affect us and the water resources they protect together with Stefano Burchi (International Association of Water Law), Marleen van Rijswick (Utrecht University) and Noah Hall (Wayne State University).https://cassyni-user-files-prod.s3.amazonaws.com/725YGXEkmy2terwmwDZ62r https://cassyni.com/slides/outline/V7GvYGJ8VMu7TMJ5oUsHho https://cassyni.com/events/V7GvYGJ8VMu7TMJ5oUsHho/abstract https://cassyni-user-files-prod.s3.amazonaws.com/SQYquTToLDNpRA33PkrQfp https://cassyni.com/events/V7GvYGJ8VMu7TMJ5oUsHho?videoPreview=1 Fifty years of Biological Fluid Dynamicsnohttps://cassyni.com/events/V7GvYGJ8VMu7TMJ5oUsHho?videoPreview=12022-04-01T15:00:00+00:004301.68Journal of Fluid MechanicsI joined the Physiological Flow Studies Unit at Imperial College, London, as a PDRA, in 1968; it was founded in 1965-6 by its Director, Colin Caro, and Sir James Lighthill. I have been working in Biological Fluid Dynamics (BFD) ever since. This talk will describe some the following selection of the topics on which I have worked; I hope it will give a feel for how BFM has changed over the years and how an applied mathematician has been able to contribute: 1. Flow and pressure drop in branched tubes: prediction of inspiratory airway resistance. 2. Unsteady boundary layer theory: calibration of hot film anemometers in reversing (arterial) flow. 3. Flow in non-uniform and collapsible tubes and channels, including unsteady separation (experiment), vorticity waves and their possible influence on wall shear stress (WSS) in arteries (experiment and theory), self-excited oscillations in collapsible channels (theory and computation), with application to lungs, veins and arteries under a cuff (and maybe giraffes). 4. Individual and collective behaviour in suspensions of swimming micro-organisms: bioconvection, gyrotaxis, continuum modelling for dilute suspensions (algae) ; bioconvection for chemotactic bacteria; squirmer models (Volvox) and cell-cell interactions leading to computations for non-dilute suspensions; trajectory measurements for Heterosigma akashiwo near vertical and horizontal plane boundaries – some unexplained phenomena.https://cassyni-user-files-prod.s3.amazonaws.com/SQYquTToLDNpRA33PkrQfp https://cassyni.com/slides/outline/XaWwmgXkgefbpHmeMAmvRj https://cassyni.com/events/XaWwmgXkgefbpHmeMAmvRj/abstract https://cassyni-user-files-prod.s3.amazonaws.com/SuCSx97KmfvsQvZvzC9Cw8 https://cassyni.com/events/XaWwmgXkgefbpHmeMAmvRj?videoPreview=1 Machine Learning for Scientific Discovery, with Examples in Fluid Mechanicsnohttps://cassyni.com/events/XaWwmgXkgefbpHmeMAmvRj?videoPreview=12022-11-04T16:00:00+00:003854.12Journal of Fluid MechanicsThis work describes how machine learning may be used to develop accurate and efficient nonlinear dynamical systems models for complex natural and engineered systems. We explore the sparse identification of nonlinear dynamics (SINDy) algorithm, which identifies a minimal dynamical system model that balances model complexity with accuracy, avoiding overfitting. This approach tends to promote models that are interpretable and generalizable, capturing the essential “physics” of the system. We also discuss the importance of learning effective coordinate systems in which the dynamics may be expected to be sparse. This sparse modeling approach will be demonstrated on a range of challenging modeling problems in fluid dynamics, and we will discuss how to incorporate these models into existing model-based control efforts. Because fluid dynamics is central to transportation, health, and defense systems, we will emphasize the importance of machine learning solutions that are interpretable, explainable, generalizable, and that respect known physics. https://cassyni-user-files-prod.s3.amazonaws.com/SuCSx97KmfvsQvZvzC9Cw8 https://cassyni.com/slides/outline/7NkLWBq3BDXhec1oRPUd1P https://cassyni.com/events/7NkLWBq3BDXhec1oRPUd1P/abstract https://cassyni-user-files-prod.s3.amazonaws.com/CM6p6WwuBwcJ7fwPozZsN6 https://cassyni.com/events/7NkLWBq3BDXhec1oRPUd1P?videoPreview=1 Information theory with kernel methodsnohttps://cassyni.com/events/7NkLWBq3BDXhec1oRPUd1P?videoPreview=12022-06-29T15:00:00+00:002754.76DataSıgI will consider the analysis of probability distributions through their associated covariance operators from reproducing kernel Hilbert spaces. In this talk, I will show that the von Neumann entropy and relative entropy of these operators are intimately related to the usual notions of Shannon entropy and relative entropy, and share many of their properties. They come together with efficient estimation algorithms from various oracles on the probability distributions. I will also present how these new notions of relative entropy lead to new upper-bounds on log partition functions, that can be used together with convex optimization within variational inference methods, providing a new family of probabilistic inference methods.https://cassyni-user-files-prod.s3.amazonaws.com/CM6p6WwuBwcJ7fwPozZsN6 https://cassyni.com/slides/outline/wcgzfiGMBSdFjmZpUUq1w https://cassyni.com/events/wcgzfiGMBSdFjmZpUUq1w/abstract https://cassyni-user-files-prod.s3.amazonaws.com/UWJfMMxnCQjEXMYGZHseV4 https://cassyni.com/events/wcgzfiGMBSdFjmZpUUq1w?videoPreview=1 A three-dimensional small-deformation theory for electrohydrodynamics of dielectric dropsnohttps://cassyni.com/events/wcgzfiGMBSdFjmZpUUq1w?videoPreview=12021-05-21T15:00:00+00:001746.24Journal of Fluid MechanicsElectrohydrodynamics of drops is a classic fluid mechanical problem where deformations and microscale flows are generated by application of an external electric field. In weak fields, electric stresses acting on the drop surface drive quadrupolar flows inside and outside and cause the drop to adopt a steady axisymmetric shape. This phenomenon is best explained by the leaky-dielectric model under the premise that a net surface charge is present at the interface while the bulk fluids are electroneutral. In the case of dielectric drops, increasing the electric field beyond a critical value can cause the drop to start rotating spontaneously and assume a steady tilted shape. This symmetry-breaking phenomenon, called Quincke rotation, arises due to the action of the interfacial electric torque countering the viscous torque on the drop, giving rise to steady rotation in sufficiently strong fields. Here, we present a small-deformation theory for the electrohydrodynamics of dielectric drops for the complete Melcher–Taylor leaky-dielectric model in three dimensions. Our theory is valid in the limits of strong capillary forces and highly viscous drops and is able to capture the transition to Quincke rotation. A coupled set of nonlinear ordinary differential equations for the induced dipole moments and shape functions are derived whose solution matches well with experimental results in the appropriate small-deformation regime. Retention of both the straining and rotational components of the flow in the governing equation for charge transport enables us to perform a linear stability analysis and derive a criterion for the applied electric field strength that must be overcome for the onset of Quincke rotation of a viscous drop.https://cassyni-user-files-prod.s3.amazonaws.com/UWJfMMxnCQjEXMYGZHseV4 https://cassyni.com/slides/outline/EHpo9ktPKdHV9R1Nnq3ZA5 https://cassyni.com/events/EHpo9ktPKdHV9R1Nnq3ZA5/abstract https://cassyni-user-files-prod.s3.amazonaws.com/CEPwkU9ag1v1GMCHWTavyL https://cassyni.com/events/EHpo9ktPKdHV9R1Nnq3ZA5?videoPreview=1 Controlling vibration using resonancenohttps://cassyni.com/events/EHpo9ktPKdHV9R1Nnq3ZA5?videoPreview=12022-07-04T07:20:00+00:001343.04ETOPIMThis talk will concentrate upon model elastic, mechanical and acoustic devices that have resonance as a key component and where grading or otherwise altering a parameter lead to interesting and useful effects. This includes focussing and redirecting wave energy. To further illustrate the control that it is possible to have over elastic waves and vibration an elastic orbital angular momentum device will be discussed that converts one wave mode into another.https://cassyni-user-files-prod.s3.amazonaws.com/CEPwkU9ag1v1GMCHWTavyL https://cassyni.com/slides/outline/Gm4pPB81Wv3yWMUwLWxBt1 https://cassyni.com/events/Gm4pPB81Wv3yWMUwLWxBt1/abstract https://cassyni-user-files-prod.s3.amazonaws.com/JkNaUmqk2c5dHCCic7vYe https://cassyni.com/events/Gm4pPB81Wv3yWMUwLWxBt1?videoPreview=1 A unifying perspective on many linear physics equations in inhomogeneous medianohttps://cassyni.com/events/Gm4pPB81Wv3yWMUwLWxBt1?videoPreview=12022-07-05T12:40:00+00:001555.04ETOPIMFollowing some past advances, we reformulate a large class of linear continuum science equations in the format of the extended abstract theory of composites so that we can apply this theory to better understand and efficiently solve those equations, and make use of minimization variational principles where applicable. The resolvent formulation can be rewritten in this form. Scattering problems also can be expressed in the desired form with an absorbing phase at infinity. The constitutive law of that phase replaces the Sommerfeld radiation condition (for acoustics) and the Silver-Muller radiation condition (for electromagnetism). The multielectron Schr ̈odinger equation can be desymmetrized and iteratively solved by going between Fourier and real space. Assuming pair-wise interactions in the potential, the Fourier transform only needs to be made on the coordinates of two electrons.https://cassyni-user-files-prod.s3.amazonaws.com/JkNaUmqk2c5dHCCic7vYe https://cassyni.com/slides/outline/9MLkgvR8w3kTkKJ2nMLZRw https://cassyni.com/events/9MLkgvR8w3kTkKJ2nMLZRw/abstract https://cassyni-user-files-prod.s3.amazonaws.com/KANb8RFGCQdEokeazxMGaS https://cassyni.com/slides/outline/BpamvLem8LWx7FmbL3FC9s https://cassyni.com/events/BpamvLem8LWx7FmbL3FC9s/abstract https://cassyni-user-files-prod.s3.amazonaws.com/2W21YkgMu9j1NkuzceajAN https://cassyni.com/events/BpamvLem8LWx7FmbL3FC9s?videoPreview=1 Depth-Targeted Energy Delivery Deep Inside Scattering Medianohttps://cassyni.com/events/BpamvLem8LWx7FmbL3FC9s?videoPreview=12022-07-08T14:40:00+00:001439.04ETOPIMWe introduce the `deposition matrix', which maps an input wavefront onto the internal field distribution inside a diffusive scattering medium. We develop a model predicting the ultimate limit for energy enhancement in an extended region at any depth. The prediction is verified in the numerical simulations and experimental measurements in two-dimensional disordered waveguides where the field anywhere inside the system can be probed from the third dimension.https://cassyni-user-files-prod.s3.amazonaws.com/2W21YkgMu9j1NkuzceajAN https://cassyni.com/slides/outline/QApWC4LmW9HY9QhoaxkMvd https://cassyni.com/events/QApWC4LmW9HY9QhoaxkMvd/abstract https://cassyni-user-files-prod.s3.amazonaws.com/FmrsosLiGFkA3HmWT8BK82 https://cassyni.com/events/QApWC4LmW9HY9QhoaxkMvd?videoPreview=1 A Methodological Shift in Favor of (Some) Paraconsistency in the Sciencesnohttps://cassyni.com/events/QApWC4LmW9HY9QhoaxkMvd?videoPreview=12022-11-16T15:00:00+00:005090.8Logica UniversalisMany have contended that non-classical logicians have failed at providing evidence of paraconsistent logics being applicable in cases of inconsistency toleration in the sciences. With this in mind, my main concern here is methodological. I aim at addressing the question of how should we study and explain cases of inconsistent science, using paraconsistent tools, without ruining into the most common methodological mistakes. My response is divided into two main parts: first, I provide some methodological guidance on how to approach cases of inconsistent science; and second, I focus on a peculiar type of formal methodologies for the scrutiny of inconsistent reasoning, the Paraconsistent Alternative Approach (henceforth, PAA) and argue that PAA can enhance a more accurate understanding of sensible reasoning in inconsistent contexts.https://cassyni-user-files-prod.s3.amazonaws.com/FmrsosLiGFkA3HmWT8BK82 https://cassyni.com/slides/outline/JjgrgYDzg7CTkYTZz3kZwB https://cassyni.com/events/JjgrgYDzg7CTkYTZz3kZwB/abstract https://cassyni-user-files-prod.s3.amazonaws.com/H2EN2UApzWrYZQZuUdNqoC https://cassyni.com/events/JjgrgYDzg7CTkYTZz3kZwB?videoPreview=1 Pilot-wave hydrodynamics, hydrodynamic quantum analogs, and hydrodynamic quantum field theorynohttps://cassyni.com/events/JjgrgYDzg7CTkYTZz3kZwB?videoPreview=12020-05-15T15:00:00+00:003906.68Journal of Fluid MechanicsIn 2005, Yves Couder and Emmanuel Fort discovered that droplets walking on a vibrating fluid bath exhibit several features previously thought to be exclusive to the microscopic, quantum realm. These walking droplets propel themselves by virtue of a resonant interaction with their own wave field, and so represent the first macroscopic realization of a pilot-wave system of the form proposed for microscopic quantum dynamics by Louis de Broglie in the 1920s. New experimental and theoretical results allow us to rationalize the emergence of quantum-like behavior in this hydrodynamic pilot-wave system in a number of settings, and explore its potential and limitations as a quantum analog. A new, trajectory-based description of quantumdynamics, informed by the hydrodynamic system, is proposed and explored.https://cassyni-user-files-prod.s3.amazonaws.com/H2EN2UApzWrYZQZuUdNqoC https://cassyni.com/slides/outline/Vbx9haTYLBNwGpHbbazFt1 https://cassyni.com/events/Vbx9haTYLBNwGpHbbazFt1/abstract https://cassyni-user-files-prod.s3.amazonaws.com/2MZwveuJKmVHaqiyL45DSN https://cassyni.com/events/Vbx9haTYLBNwGpHbbazFt1?videoPreview=1 Concentration and velocity measurement of dispersed multiphase flows using PIV methodsnohttps://cassyni.com/events/Vbx9haTYLBNwGpHbbazFt1?videoPreview=12023-01-24T15:00:00+00:002935.32Experiments in FluidsDispersed multiphase flows are ubiquitous across nature and many engineering applications. They frequently exist under turbulent conditions, creating challenging for predictive models due to a requirement for mass, momentum, and energy closures not only for the carrier fluid phase, but also for the exchange between the phases. As a result, the holy grail for measurements within turbulent dispersed multiphase flows has been the instantaneous measurement of the velocity of both phases in addition to the concentration of the dispersed phase. PIV is an obvious choice for measurement of these quantities, but there are significant challenges: 1) discrimination of the signals provided by carrier phase tracer particles distinct from the dispersed phase, 2) obscuration due to multiple-scatter conditions are even relatively small volume fractions of the dispersed phase, 3) influence of non-uniform illumination conditions on consistently identifying scattering objects as one phase or the other and 4) determining the boundaries of a clearly defined measurement volume. In this presentation, I will highlight these challenges and the methods we have developed to account for them when making measurements in these flows, along with results and applications from turbulent sediment-laden boundary layers typical of coastal flows. https://cassyni-user-files-prod.s3.amazonaws.com/2MZwveuJKmVHaqiyL45DSN https://cassyni.com/slides/outline/UcewcDAVTGGnc4TbVcWw57 https://cassyni.com/events/UcewcDAVTGGnc4TbVcWw57/abstract https://cassyni-user-files-prod.s3.amazonaws.com/SphRnQ6bBee7xmsMzyjGyc https://cassyni.com/events/UcewcDAVTGGnc4TbVcWw57?videoPreview=1 The Legendre Memory Unit: A neural network with optimal time series compressionnohttps://cassyni.com/events/UcewcDAVTGGnc4TbVcWw57?videoPreview=12022-11-24T16:00:00+00:002220.04DataSıgWe have recently proposed a new kind of neural network, called a Legendre Memory Unit (LMU) that is provably optimal for compressing streaming time series data. In this talk, I describe this network, and a variety of state-of-the-art results that have been set using the LMU. I will include recent results on speech and language applications that demonstrate significant improvements over transformers. I will discuss variants of the original LMU that permit effective scaling on current GPUs and hold promise to provide extremely efficient edge time series processing.https://cassyni-user-files-prod.s3.amazonaws.com/SphRnQ6bBee7xmsMzyjGyc https://cassyni.com/slides/outline/4QtLLiTmwq8tSNhkZqDdem https://cassyni.com/events/4QtLLiTmwq8tSNhkZqDdem/abstract https://cassyni-user-files-prod.s3.amazonaws.com/CD2gVD1X8pruqZE7x6ZAxv https://cassyni.com/events/4QtLLiTmwq8tSNhkZqDdem?videoPreview=1 Multi-Fidelity Methods for Uncertainty Propagation in Kinetic Equationsnohttps://cassyni.com/events/4QtLLiTmwq8tSNhkZqDdem?videoPreview=12023-02-06T15:00:00+00:003238.6Journal of Computational PhysicsThe Boltzmann equation is used to model a very large number of different phenomena ranging from rarefied gas flows such as those found in hypersonic aerodynamics, gases in vacuum technologies, or fluids inside microelectromechanical devices, to the description of social and biological phenomena. The development of efficient and accurate numerical methods for solving kinetic equations and in particular the Boltzmann equation has a long history while the study of such equations with stochastic terms has been considered only in recent years. On the other hand, these uncertainties arise naturally in many problems where these models are frequently used. In particular, incomplete knowledge of the interaction mechanism between the particles, imprecise measurements of the initial and boundary data, and unknown details of the domain geometry or forcing terms represent problems that are nearly impossible to overcome in a fully deterministic environment. Non-intrusive sampling methods, such as Monte Carlo sampling, have several advantages over other approaches, as they allow to be used in combination with existing deterministic numerical solvers designed to satisfy certain relevant physical properties. In this talk, we survey some recent results about multi-fidelity methods for kinetic equations that accelerate the solution of the uncertainty quantification process based on stochastic samples by combining high-fidelity and low-fidelity model evaluations.https://cassyni-user-files-prod.s3.amazonaws.com/CD2gVD1X8pruqZE7x6ZAxv https://cassyni.com/slides/outline/EnW2K53oASmJxsztawAXLH https://cassyni.com/events/EnW2K53oASmJxsztawAXLH/abstract https://cassyni-user-files-prod.s3.amazonaws.com/MGQP1i4wFFQejuCZwsJX74 https://cassyni.com/events/EnW2K53oASmJxsztawAXLH?videoPreview=1 Path Development and the Length Conjecturenohttps://cassyni.com/events/EnW2K53oASmJxsztawAXLH?videoPreview=12021-02-17T09:00:00+00:003347.12DataSıgIt was implicitly conjectured by Hambly-Lyons in 2010, which was made explicit by Chang-Lyons-Ni in 2018, that the length of a tree-reduced path with bounded variation can be recovered from its signature asymptotics. Apart from its intrinsic elegance, understanding such a phenomenon is also important for the study of signature lower bounds and may shed light on more general signature inversion properties. In this talk, we discuss how the idea of path development onto suitably chosen Lie groups can be used to study this problem as well as its rough path analogue.https://cassyni-user-files-prod.s3.amazonaws.com/MGQP1i4wFFQejuCZwsJX74 https://cassyni.com/slides/outline/FH9dMkhKbuKMxeXnBNTKbb https://cassyni.com/events/FH9dMkhKbuKMxeXnBNTKbb/abstract https://cassyni-user-files-prod.s3.amazonaws.com/HiTydR6DSQkipkJLWYDi8N https://cassyni.com/events/FH9dMkhKbuKMxeXnBNTKbb?videoPreview=1 12 Labours Seminar Series: Decrypting Puzzles of the Uterusnohttps://cassyni.com/events/FH9dMkhKbuKMxeXnBNTKbb?videoPreview=12023-10-03T23:00:00+00:002769.8Auckland Bioengineering InstituteDrawing from both experimental and theoretical expertise, the 12 Labours vision for assembly of clinically relevant and customised representations of organ system includes the uterus. Amy and Shawn will present their work as part of Exemplar Project 3, looking at insights into the electrical signaling across the uterine tissue and the yet-undetermined pacemaking mechanism in the uterus. The musculature of the uterus is composed of smooth muscle cells, which exhibit the astonishing ability to maintain the uterus and facilitate menstruation in non-pregnancy. However during pregnancy, they are able to remain minimally active while the baby is developing, yet produce large, coordinated contraction events during labour and delivery. Together Amy and Shawn will present results for potential mechanisms generating not only pacemaking signals in the uterus — with no explicit pacemaker -- but also spatial organisation of electrical waves key to uterine function.https://cassyni-user-files-prod.s3.amazonaws.com/HiTydR6DSQkipkJLWYDi8N https://cassyni.com/slides/outline/9r1yrEaYmsEHZnHYaTTXc9 https://cassyni.com/events/9r1yrEaYmsEHZnHYaTTXc9/abstract https://cassyni-user-files-prod.s3.amazonaws.com/ChgHXtf3aHR1WYXETdjhWW https://cassyni.com/events/9r1yrEaYmsEHZnHYaTTXc9?videoPreview=1 A Low Rank Tensor Approach for Nonlinear Vlasov Simulationsnohttps://cassyni.com/events/9r1yrEaYmsEHZnHYaTTXc9?videoPreview=12023-09-25T14:00:00+00:003173.28Journal of Computational PhysicsIn this work, we present a low-rank tensor approach for approximating solutions to the nonlinear Vlasov equation. Our method takes advantage of the tensor-friendly nature of the differential operators in the Vlasov equation to dynamically and adaptively construct a low-rank solution basis through the discretization of the equation and an SVD-type truncation procedure. We utilize finite difference WENO and discontinuous Galerkin spatial discretizations, along with a second-order strong stability preserving multi-step time discretization. To preserve conservation properties, we develop low-rank schemes with local mass, momentum, and energy conservation for the corresponding macroscopic equations. The mass and momentum are conserved using a conservative SVD truncation, while the energy is conserved by replacing the energy component of the kinetic solution with one obtained from a conservative scheme for the macroscopic energy equation. We employ hierarchical Tucker decomposition for high-dimensional problems, and demonstrate the high-order convergence, efficiency, and local conservation properties of our algorithm through a series of linear and nonlinear Vlasov examples.https://cassyni-user-files-prod.s3.amazonaws.com/ChgHXtf3aHR1WYXETdjhWW https://cassyni.com/events/Liyqj1hFVxa26S44APwiu3/seminar/qa https://cassyni.com/slides/outline/Liyqj1hFVxa26S44APwiu3 https://cassyni.com/events/Liyqj1hFVxa26S44APwiu3/abstract https://cassyni-user-files-prod.s3.amazonaws.com/7o48wH1dBFUveFb9bxuSrr https://cassyni.com/events/Liyqj1hFVxa26S44APwiu3?videoPreview=1 Pattern recognition in living cells through the lens of machine learningnohttps://cassyni.com/events/Liyqj1hFVxa26S44APwiu3?videoPreview=12025-11-24T15:00:00+00:002776.6Royal Society PublishingThis article is [Royal Society *Open Biology*’s 2024 Open Questions Article Prize winner](https://royalsociety.org/journals/publishing-activities/open-questions-competition/). At a coarse level, pattern recognition within cells involves sensing of environmental signals by surface receptors, and activating downstream signalling pathways that ultimately drive a transcriptome response, enabling biological functions such as differentiation, migration, proliferation, apoptosis or cell-type specification. This kind of decision-making process resembles a classification task that, inspired by machine learning concepts, can be understood in terms of a decision boundary: the combination of inputs relative to the classification region defined by this boundary defines context-specific responses. In this report, we contextualize machine learning concepts within a biological framework to explore the structural and functional similarities (and differences) between artificial neural networks, signalling pathways and gene regulatory networks. We take a preliminary look at neural network architectures that may better suit biological classification tasks, explore how learning fits into this paradigm, and address the role of competitive binding in cellular computation. Altogether, we envision a new research direction at the intersection of systems and synthetic biology, advancing our understanding of the inherent computational capacities of signalling pathways and gene regulatory networks. https://cassyni-user-files-prod.s3.amazonaws.com/7o48wH1dBFUveFb9bxuSrr https://cassyni.com/slides/outline/T9TwZA8r1dd4s5Cij52tS1 https://cassyni.com/events/T9TwZA8r1dd4s5Cij52tS1/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Pm4F8knwwg2Gt7mKPuup78 https://cassyni.com/events/T9TwZA8r1dd4s5Cij52tS1?videoPreview=1 Implementing point of care ultrasound (POCUS) education and clinical integration in western Kenyanohttps://cassyni.com/events/T9TwZA8r1dd4s5Cij52tS1?videoPreview=12025-03-06T21:00:00+00:003820.6Family MedicineParticipants will be able to... 1. Describe the significant gap in access to diagnostic testing in rural areas in LMICs like Kenya 1. Define point of care ultrasound and how it differs from formal ultrasonography 1. Summarize methods that can be used to measure implementation science outcomes like feasibility and acceptability with regard to implementing POCUShttps://cassyni-user-files-prod.s3.amazonaws.com/Pm4F8knwwg2Gt7mKPuup78 https://cassyni.com/slides/outline/Nhf8Fdq1TsZbE7uZ266VCR https://cassyni.com/events/Nhf8Fdq1TsZbE7uZ266VCR/abstract https://cassyni-user-files-prod.s3.amazonaws.com/KP6tmYyhp6c7RsLyBFmXNe https://cassyni.com/events/Nhf8Fdq1TsZbE7uZ266VCR?videoPreview=1 Early Cretaceous volcanic-arc magmatism in the Dalat-Kratie Fold Belt of eastern Cambodia: implications for the lithotectonic evolution of the Indochina terranenohttps://cassyni.com/events/Nhf8Fdq1TsZbE7uZ266VCR?videoPreview=12024-11-27T11:00:00+00:003122.04Frontiers in Earth ScienceMesozoic granitic plutons are found throughout the Indochina terrane of eastern Cambodia and southern Vietnam. The granitic rocks range in age from Early Triassic (240 Ma) to Late Cretaceous (80 Ma) and record distinct tectonomagmatic periods associated with subduction of the Paleotethys and Paleo-Pacific oceans. Samples collected from the Snoul pluton, eastern Cambodia are composed of silicic and intermediate dioritic rocks, and basalt. The quartz diorites and diorites are magnesian, metaluminous, calcic to calc-alkalic, and similar to volcanic-arc granitoids whereas the basaltic rocks are compositionally similar to within-plate basalt. Zircon U-Pb geochronology and Lu-Hf isotopes and whole rock Sr-Nd isotopes show that the silicic rocks are Albian and isotopically juvenile (107.5 ± 0.3 Ma, 109.1 ± 0.4 Ma; εHf(t) = +7.0–+17.0; 87Sr/86Sri = 0.704313–0.707681; εNd(t) = +3.1–+4.9). Fractional crystallization modeling using a dioritic composition as the parental magma demonstrates that it is possible to generate the quartz diorite compositions under oxidizing (ΔFMQ +1) and hydrous (H2O = 2 wt%) conditions suggesting that they are consanguineous. The isotopically juvenile nature of the dioritic rocks and their compositional similarity (SiO2 ≥ 56 wt%, Al2O3 ≥ 15 wt%, Sr ≥ 400 ppm, Y ≤ 18 ppm, Yb ≤ 1.9 ppm) to adakitic rocks indicates that the parental magmas of the Snoul pluton were likely derived by partial melting of juvenile mafic basement rocks of the Indochina terrane. Moreover, Early Cretaceous plutonic rocks of Cambodia are isotopically distinct from plutonic rocks of similar age and tectonic setting from Vietnam suggesting that there could be a lithotectonic domain boundary within the Southern Indochina terrane. In contrast, the basaltic rocks likely record a temporally distinct period of magmatism associated with Late Cenozoic tensional plate stress.https://cassyni-user-files-prod.s3.amazonaws.com/KP6tmYyhp6c7RsLyBFmXNe https://cassyni.com/slides/outline/9rkApbybFFKBNCPz1Ds22H https://cassyni.com/events/9rkApbybFFKBNCPz1Ds22H/abstract https://cassyni-user-files-prod.s3.amazonaws.com/BPEA4vsKBFsu4Cd1e51AXp https://cassyni.com/events/9rkApbybFFKBNCPz1Ds22H?videoPreview=1 The Politics of Innovation feat. Mark Zachary Taylornohttps://cassyni.com/events/9rkApbybFFKBNCPz1Ds22H?videoPreview=12022-10-17T10:00:00+00:003399.04 School of Public PolicyInnovation seems to occur at uneven rates across different countries. At a time when we’re so intimately connected in all fields and industries, its interesting that there are still such vastly different kinds of technology and innovation happening at the same time all over the world. Dr. Mark Zachary Taylor, formerly a solid-state physicist, now specializes in S&T politics and policy, political economy, the American presidency, and comparative politics. In his research, he tries to understand the sources of national economic competitiveness. In his book, “The Politics of Innovation,” he seeks to explain why some countries are better than others at science and technology. He currently studies the role of the US presidency in short-run economic performance, as well as an Associate Professor at the School of Public Policy at Georgia Institute of Technology. Following the ideas of Cardwell’s Law, Greg and Zach discuss the uneven distribution of innovation globally, how and why we got to this place, and the role of government investments. https://cassyni-user-files-prod.s3.amazonaws.com/BPEA4vsKBFsu4Cd1e51AXp https://cassyni.com/slides/outline/Te9AiUJFrT6tgYCEXB9rcD https://cassyni.com/events/Te9AiUJFrT6tgYCEXB9rcD/abstract https://cassyni-user-files-prod.s3.amazonaws.com/SeYZrFnnn1H4jkVoiuRewG https://cassyni.com/events/Te9AiUJFrT6tgYCEXB9rcD?videoPreview=1 Multivariate P- and Q-polynomial association schemesnohttps://cassyni.com/events/Te9AiUJFrT6tgYCEXB9rcD?videoPreview=12025-01-07T13:00:00+00:003993.44The Journal of Algebraic CombinatoricsThis talk is based on the two joint papers [1] and [2] with Hirotake Kurihara (Yamaguchi University), Da Zhao (East China University of Science and Technology) and Yan Zhu (Shanghai University for Science and Technology). The classification problem of P-and Q-polynomial association schemes has been one of the very important problems in algebraic combinatorics. The theorem of Leonard (1982) that the spherical functions as well as their character tables are expressed by Askey-Wilson polynomials and their special cases or relatives (i.e., limiting cases) was the important starting point. These polynomials are one variable orthogonal polynomials. It seems that there have been many studies of multivariable generalizations of Askey-Wilson polynomials (at the level of orthogonal polynomials), but it seems that multivariable version of P-and Q-polynomial association schemes (i.e., higher rank P-and Q-polynomial association schemes) has not been studied much except for some very special cases. Recently, the first very successful attempt was made by Bernard-Crampé-d'Andecy- Vinet-Zaimi [3] for bivariate P-polynomial (or Q-polynomial) association schemes. Then, motivated by [3], we obtained in [1] the concept of multivariate P-polynomial (or Q-polynomial) association schemes for any monomial order. The purpose of this talk is first to review the development of the study of P-and/or Q-polynomial association schemes of higher rank following [1],[3]. Then we will discuss some explicit examples of multivariate P-and Q-polynomial association schemes following [1], [2], [3] and so on. Finally, we will give some speculations concerning to which direction this study should proceed. https://cassyni-user-files-prod.s3.amazonaws.com/SeYZrFnnn1H4jkVoiuRewG https://cassyni.com/events/2wixQHx1uZQwX5uVzxZkvZ/seminar/qa https://cassyni.com/slides/outline/2wixQHx1uZQwX5uVzxZkvZ https://cassyni.com/events/2wixQHx1uZQwX5uVzxZkvZ/abstract https://cassyni-user-files-prod.s3.amazonaws.com/D1XNAXDxTCXP8XabU31Rw4 https://cassyni.com/events/2wixQHx1uZQwX5uVzxZkvZ?videoPreview=1 A quantum graph approach to metamaterial designnohttps://cassyni.com/events/2wixQHx1uZQwX5uVzxZkvZ?videoPreview=12025-03-04T14:00:00+00:002720.2MetaMATWe consider a quantum graph approach for designing metamaterials. An infinite square periodic quantum graph, constructed from vertices and edges, acts as a paradigm for a 2D metamaterial. Wave transport occurs along the edges with vertices acting as scatterers modelling sub-wavelength resonant elements. These resonant elements are constructed with the help of finite quantum graphs attached to each vertex of the lattice with customisable properties controlled by a unitary scattering matrix. The metamaterial properties are understood and engineered by manipulating the band diagram of the periodic structure. The engineered properties are then demonstrated in terms of the reflection and transmission behaviour of Gaussian beam solutions at interfaces between different metamaterials. We demonstrate negative refraction, beam steering and wave vector filtering among other effects both within our model and in experiments based on interconnected acoustic tubes. https://cassyni-user-files-prod.s3.amazonaws.com/D1XNAXDxTCXP8XabU31Rw4 https://cassyni.com/slides/outline/SepLWUVKaB51sJfq8dk6Ah https://cassyni.com/events/SepLWUVKaB51sJfq8dk6Ah/abstract https://cassyni-user-files-prod.s3.amazonaws.com/BFzvkocfpZGoMQ1bdHWMdY https://cassyni.com/events/SepLWUVKaB51sJfq8dk6Ah?videoPreview=1 Enhanced internal dosimetry for alimentary tract organs in nuclear medicine based on the ICRP mesh-type reference phantomsnohttps://cassyni.com/events/SepLWUVKaB51sJfq8dk6Ah?videoPreview=12024-12-20T10:00:00+00:00988.28National Institutes of HealthThis study introduces a refined approach for more accurately estimating radiation doses to alimentary tract organs in nuclear medicine, by utilizing the ICRP pediatric and adult mesh-type reference computational phantoms (MRCPs) that improved the anatomical representation of these organs. Our initial step involved compiling a comprehensive dataset of electron Specific Absorbed Fractions (SAFs) for all source-target pairs of alimentary tract organs in both adult and pediatric phantoms, calculating SAFs for all cases in the present study only except those computed in the previous study for certain pediatric phantom cases. Subsequently, we determined S values for 1,252 radionuclides, facilitating dosimetry applications. The consistency of target and source masses for alimentary tract organs in the MRCPs with the reference values in ICRP Publication 89 led to noticeable differences in SAF, S values, and consequently, absorbed dose coefficients when compared to the stylized models in ICRP Publication 100. Notably, the S value ratios (MRCP/stylized) for selected radionuclides—11C, 18F, 68Ga, and 131I—ranged from 0.41 to 7.60. Particularly for therapeutic 131I-iodide in thyroid cancer, the use of MRCPs resulted in up to 1.49 times higher absorbed dose coefficients for the colon than those derived from stylized models, while the stomach dose coefficients decreased by a factor of 0.72. The application of our findings promises enhanced, more realistic dosimetry for alimentary tract organs, especially beneficial for radiopharmaceuticals likely to accumulate within these organs.https://cassyni-user-files-prod.s3.amazonaws.com/BFzvkocfpZGoMQ1bdHWMdY https://cassyni.com/events/4vHkUQ2EG2hc4ZPYkYMRUH/seminar/qa https://cassyni.com/slides/outline/4vHkUQ2EG2hc4ZPYkYMRUH https://cassyni.com/events/4vHkUQ2EG2hc4ZPYkYMRUH/abstract https://cassyni-user-files-prod.s3.amazonaws.com/637zwiUGm5QvLhb1sgx1dp https://cassyni.com/events/4vHkUQ2EG2hc4ZPYkYMRUH?videoPreview=1 Glasses: From Physical Hamiltonians to Neural Networks and Backnohttps://cassyni.com/events/4vHkUQ2EG2hc4ZPYkYMRUH?videoPreview=12024-12-05T12:00:00+00:003481.04Annals of PhysicsThis talk will review our recent work on classical and quantum glasses. I will start with a discussion of spin glasses from the perspective of chaos theory. The Thouless-Anderson-Palmer (TAP) formalism will be introduced to "visualize" the landscape of metastable energy minima in such systems. The quantization of the TAP equations will be introduced and used to explore the spectral form factor (SFF)—a key metric of quantum chaos—in certain models of quantum glasses. It will be shown that the hallmark of quantum chaos—a ramp in the SFF—is rescaled by the exponential of complexity compared to the standard chaotic (random matrix) model. I will briefly mention the realization of such models in glassy quantum circuits, which exhibit slow thermalization. Next, a one-to-one correspondence between classical spin models and neural networks (NNs) will be established. Training a NN in this mapping corresponds to a family of spin Hamiltonians parameterized by training time. TAP equations will be used to show that training a NN on a classification task physically implies the destruction of the spin glass and the emergence of hidden order, whose melting temperature increases as a power law with training time. This provides an appealing physical picture of training neural networks as a search for hidden order associated with the task. Finally, a natural quantization of neural networks will be introduced, and I will argue that some test cases are readily deployable on present-day quantum computers.https://cassyni-user-files-prod.s3.amazonaws.com/637zwiUGm5QvLhb1sgx1dp https://cassyni.com/slides/outline/HmB5noMm5J2Zq2CD1cPVUH https://cassyni.com/events/HmB5noMm5J2Zq2CD1cPVUH/abstract https://cassyni-user-files-prod.s3.amazonaws.com/VuKkeq5V4Kwk5aGBWH5NDt https://cassyni.com/events/HmB5noMm5J2Zq2CD1cPVUH?videoPreview=1 EP2: AI for Molecular Dynamics and Protein-Engineeringnohttps://cassyni.com/events/HmB5noMm5J2Zq2CD1cPVUH?videoPreview=12024-10-29T01:00:00+00:006438.2Institute of Natural Sciences第二期研讨邀请上海交通大学自然科学研究院院长、数学科学学院讲席教授金石，上海交通大学数学科学学院教授徐振礼，上海交通大学自然科学研究院教授洪亮，聚焦科学中的人工智能，探讨在微观模拟领域中AI与数学的融合。https://cassyni-user-files-prod.s3.amazonaws.com/VuKkeq5V4Kwk5aGBWH5NDt https://cassyni.com/slides/outline/W7PBwtXt3jsRihS1yxxDcR https://cassyni.com/events/W7PBwtXt3jsRihS1yxxDcR/abstract https://cassyni-user-files-prod.s3.amazonaws.com/TRdNS1C1iQ7uaX7HcSsP6e https://cassyni.com/events/W7PBwtXt3jsRihS1yxxDcR?videoPreview=1 Ozone and CO2 signalling in stomatal guard cells – a personal tribute to Jaakko Kangasjärvinohttps://cassyni.com/events/W7PBwtXt3jsRihS1yxxDcR?videoPreview=12024-10-23T13:00:00+00:001886.44The New Phytologist FoundationIn my talk, I would like to honour the work of Jaakko Kangasjärvi, who passed away on May 14, 2024. Jaakko was an excellent colleague, an inspiring mentor, and he made a major contribution to several fields of plant biology, including stomatal regulation. Back in early 90’s, after returning from US, Jaakko initiated an ozone-sensitivity-based mutant screen to study hormonal regulation of ROS-induced cell death. This screen also identified guard cell anion channel SLAC1; a target of cellular signalling systems triggered by majority of stimuli affecting stomatal closure. It also helped to define interaction between MPK12/4:HT1 kinases as a molecular switch regulating CO2-induced stomatal movements, and clarified the function of other important guard cell proteins, such as GHR1, OST1 etc. Roughly 10 years ago when we initiated Helsinki-Tartu joint mutant screen, Jaakko’s main aim was to identify proteins involved in ozone sensing in guard cells. The screen was again based on ozone sensitivity but designed as saturating and focused on finding proteins involved in stomatal regulation by environmental factors. Now when we are ready to report early steps of ozone sensing in guard cells, he is unfortunately not among us anymore.https://cassyni-user-files-prod.s3.amazonaws.com/TRdNS1C1iQ7uaX7HcSsP6e https://cassyni.com/slides/outline/DozFRLBZZdbR3MjXcVoSsP https://cassyni.com/events/DozFRLBZZdbR3MjXcVoSsP/abstract https://cassyni-user-files-prod.s3.amazonaws.com/XVvyVhALCgvfXUj1nFzfnn https://cassyni.com/events/DozFRLBZZdbR3MjXcVoSsP?videoPreview=1 Eligibility Criteria and Representative Cancer Clinical Trialsnohttps://cassyni.com/events/DozFRLBZZdbR3MjXcVoSsP?videoPreview=12025-11-20T19:00:00+00:003693.76Center for Cancer TrainingEligibility criteria in cancer clinical trials are intended to select the target population and limit the exposure of participants to foreseeable risks. In recent years there has been growing concern that these criteria may inadvertently limit representative participation, meaning that their restrictiveness is not justified by safety concerns. This limits the generalizability of trial data to the target population, which may have more comorbid conditions and other differential characteristics from those enrolled. There are few data, however, on the extent to which these criteria are overly restrictive or inappropriately liberal relative to safety data, or how variable justifications are across trials. Data are also limited on how these deficiencies impact the representation of the target population. In a series of studies, we assessed the extent to which cancer trial criteria are justified by safety data and, when compared to alternative criteria generated based on federal and expertise guidance and drug safety data known at study inception, how criteria restiveness impact representation of various demographic groups. We then look at various components of criteria and their use, such as copying-and-pasting criteria during trial development, and the impact of Duffy status on neutrophil count-related criteria.https://cassyni-user-files-prod.s3.amazonaws.com/XVvyVhALCgvfXUj1nFzfnn https://cassyni.com/slides/outline/Cph3KxtWgiVGNbuXWXL84V https://cassyni.com/events/Cph3KxtWgiVGNbuXWXL84V/abstract https://cassyni-user-files-prod.s3.amazonaws.com/7J1vAwgZSKtmCzmnoTXKpa https://cassyni.com/events/Cph3KxtWgiVGNbuXWXL84V?videoPreview=1 Multilevel Predictors of Disparities in Ovarian Cancer Outcomesnohttps://cassyni.com/events/Cph3KxtWgiVGNbuXWXL84V?videoPreview=12025-09-18T18:00:00+00:003643.92Center for Cancer TrainingEpithelial ovarian cancer (EOC) is the fifth leading cause of cancer related mortality among women in the US. Despite advances in surgical approaches and systemic therapies, overall survival has improved only marginally over the past thirty years. Moreover, there are robust and well-documented disparities in EOC mortality. Factors that are thought to contribute to these disparities include access to and quality of care, disease severity, and socioeconomic factors. Still, accounting for these characteristics in multivariable-adjusted models fails to fully explain the observed disparity. Therefore, a more comprehensive examination of factors that impact the inequity in a diverse sample is vital to identify points of intervention and improve EOC survivorship. EOC is a heterogeneous disease with distinct histotypes that inform prognosis. High-grade serous carcinoma (HGSC) is the most common histotype, comprising ~70% of all EOC diagnoses. Recently, three robust gene expression signatures have been developed that have the potential to inform risk assessment and biomarker-driven therapeutic approaches for HGSC patients. Each signature correlates to differential survival, suggesting utility in informing HGSC prognosis and guiding treatment intensity. However, no study has compared the performance of these tumor gene expression signatures across populations. Evaluation of these gene expression signatures is important for understanding the clinical implications. In this presentation, Dr. Collin will present work related to her NCI-funded K99/R00, which seeks to understand sociocontextual, patient demographic, clinicopathologic, and molecular features associated with disparities EOC outcomes. She will present work related to factors that contribute to disparities leveraging data from Kaiser Permanente Northern California.https://cassyni-user-files-prod.s3.amazonaws.com/7J1vAwgZSKtmCzmnoTXKpa https://cassyni.com/events/PgyxTddwk9bU3MRxQdWFdw/seminar/qa https://cassyni.com/slides/outline/PgyxTddwk9bU3MRxQdWFdw https://cassyni.com/events/PgyxTddwk9bU3MRxQdWFdw/abstract https://cassyni-user-files-prod.s3.amazonaws.com/N3anx7LuzC3Jc4CzUnqYQW https://cassyni.com/events/PgyxTddwk9bU3MRxQdWFdw?videoPreview=1 Kidney Disease in the Public Health Agendanohttps://cassyni.com/events/PgyxTddwk9bU3MRxQdWFdw?videoPreview=12025-04-28T13:00:00+00:003677.04Springer Nature Sustainable Development Goals ProgrammeNon-communicable diseases (NCDs) are the leading causes of premature mortality worldwide, with cardiovascular disease, cancer, chronic respiratory disease and diabetes considered to be the key contributors. However, the global prevalence of kidney disease is higher than that of any of these four NCDs. In 2024, a [Consensus Statement](https://www.nature.com/articles/s41581-024-00820-6) led by the American Society of Nephrology (ASN), European Renal Association (ERA) and International Society of Nephrology (ISN) called for kidney disease to be prioritized by the WHO as a major NCD driver of premature mortality. The WHO 78th World Health Assembly (WHA78) will convene in May 2025 and, for the first time, member states will discuss the adoption of a [kidney resolution](https://apps.who.int/gb/ebwha/pdf_files/EB156/B156_(20)-en.pdf) (proposed by Guatemala), which puts forward the promotion of kidney health and strengthening prevention and control of kidney disease as key steps to reduce the global burden of non-communicable diseases (see [SDG3.4](https://www.who.int/data/gho/data/themes/topics/sdg-target-3_4-noncommunicable-diseases-and-mental-health) ). *Nature Reviews Nephrology* welcomes you to this webinar, in which our speakers — Joaquin Barnoya (Guatemalan Health Minister), Prabir Roy-Chaudhury (ASN), Roser Torra (ERA) and Marcello Tonelli (ISN)— will discuss the current landscape of kidney disease in the public health agenda, and how to address the growing global burden of kidney disease. For a snapshot of the global burden of kidney disease see our [infographic](https://www.nature.com/articles/s41581-024-00829-x/figures/1) (Arabic, Chinese, French, Hindi, Portuguese and Spanish versions also available in the [supplementary information](https://www.nature.com/articles/s41581-024-00829-x#Sec1) ).https://cassyni-user-files-prod.s3.amazonaws.com/N3anx7LuzC3Jc4CzUnqYQW https://cassyni.com/events/Wc4R7ChHtZMFYARXn55Bnd/seminar/qa https://cassyni.com/slides/outline/Wc4R7ChHtZMFYARXn55Bnd https://cassyni.com/events/Wc4R7ChHtZMFYARXn55Bnd/abstract https://cassyni-user-files-prod.s3.amazonaws.com/AGRSDEgX6mSaBuQkCxo9k2 https://cassyni.com/events/Wc4R7ChHtZMFYARXn55Bnd?videoPreview=1 Analytic theories for magnetic skyrmionsnohttps://cassyni.com/events/Wc4R7ChHtZMFYARXn55Bnd?videoPreview=12025-02-17T21:00:00+00:002928.28The MacDiarmid Institute for Advanced Materials and NanotechnologySkyrmions are tiny swirls in the local magnetization that can exist in thin films at room temperatures. They were only imaged for the first time in 2009 and are promising candidates for high-density and low-energy data storage. A key to their existence is an asymmetric magnetic exchange interaction known as the “Dzyaloshinskii-Moriya interaction” (DMI). In this talk, I will discuss our analytic models for predicting the size of skyrmions. These analytic tools provide scientists and engineers with an easy way to make predictions about new magnetic materials for data storage applications.https://cassyni-user-files-prod.s3.amazonaws.com/AGRSDEgX6mSaBuQkCxo9k2 https://cassyni.com/slides/outline/RfaNeNE3VypE94iBmbNC4V https://cassyni.com/events/RfaNeNE3VypE94iBmbNC4V/abstract https://cassyni-user-files-prod.s3.amazonaws.com/JPRajgPFy7dC9GGvKXyrYN https://cassyni.com/events/RfaNeNE3VypE94iBmbNC4V?videoPreview=1 Uncovering how plant roots sense soil stressesnohttps://cassyni.com/events/RfaNeNE3VypE94iBmbNC4V?videoPreview=12024-08-12T12:00:00+00:001449.12The New Phytologist FoundationPlants exhibit a remarkable ability to modify their growth and development in response to environmental signals and stresses. This ability is particularly striking during root development where they forage in highly heterogeneous environments. I will describe how plant hormones enable roots to sense and/or respond to soil environmental signals. Examples include discovering how plants sense soil moisture availability by linking intercellular water fluxes with movement of hormones auxin and ABA, triggering changes in root branching designed to maximise capture of soil resources (Orosa et al, 2018, Science; Mehra et al, 2022, Science). Plant roots also employ volatile signals like ethylene to sense changes in soil physical properties like compaction stress using a novel gas diffusion based mechanism (Pandey et al, 2021, Science). I will conclude by describing how mechanistic insights about hormone-regulated root plasticity, combined with advances in technologies including single cell expression profiling, are helping design stress resilient crops.https://cassyni-user-files-prod.s3.amazonaws.com/JPRajgPFy7dC9GGvKXyrYN https://cassyni.com/slides/outline/6QHoqhzaP8DMNUfgrHmtNH https://cassyni.com/events/6QHoqhzaP8DMNUfgrHmtNH/abstract https://cassyni-user-files-prod.s3.amazonaws.com/NYEPznzSRebQH3W6zL24x6 https://cassyni.com/events/6QHoqhzaP8DMNUfgrHmtNH?videoPreview=1 Advancing SDG 12: The Business Imperative for Sustainable Consumption and Productionnohttps://cassyni.com/events/6QHoqhzaP8DMNUfgrHmtNH?videoPreview=12025-03-06T10:00:00+00:003175.12Springer Nature Sustainable Development Goals ProgrammeJoin us for an insightful webinar on "Advancing SDG 12: The Business Imperative for Sustainable Consumption and Production". Our distinguished speakers include: **Dr. René R. Schmidpeter**, Editor-in-Chief of the Journal of Sustainable Business, and **Dr. Alexandros Stefanakis**, Editor-in-Chief of Circular Economy and Sustainability. This event will delve into the pivotal role that businesses play in achieving Sustainable Development Goal 12, which emphasizes sustainable consumption and production patterns. Key topics include: 1.The importance of SDG 12, highlighting both challenges and opportunities, and the crucial role businesses play in meeting its targets. 2. Effective strategies for sustainable supply chain management, transitioning to a circular economy, and harnessing innovation and technology. 3. The significance of measuring and reporting on sustainability for businesses to drive accountability and progress. This webinar aims to foster a deeper understanding and stimulate multidisciplinary dialogues among industry leaders, sustainability experts, and business professionals. Don't miss this opportunity to learn, share, and collaborate on advancing SDG 12 through sustainable business practices. This is the **inaugural webinar** in a series organized by the SDG 12 Working Group under the theme "Sustainable Industries for SDG 12." Starting in March 2025, the series will feature six or more panels that will cover key aspects of sustainable practices across different industries. https://cassyni-user-files-prod.s3.amazonaws.com/NYEPznzSRebQH3W6zL24x6 https://cassyni.com/slides/outline/TomNsXKzYgKyNxLqp4te9 https://cassyni.com/events/TomNsXKzYgKyNxLqp4te9/abstract https://cassyni-user-files-prod.s3.amazonaws.com/CuovanY5eJqCX8GKadKC2i https://cassyni.com/events/TomNsXKzYgKyNxLqp4te9?videoPreview=1 Deep Learning-Based Surface Reconstruction from Point Cloudsnohttps://cassyni.com/events/TomNsXKzYgKyNxLqp4te9?videoPreview=12024-12-06T17:00:00+00:001883.28JKW Symposium TeamNo abstracthttps://cassyni-user-files-prod.s3.amazonaws.com/CuovanY5eJqCX8GKadKC2i https://cassyni.com/events/3w3ncHkxBqSpLKRuPVyXN5/abstract https://cassyni-user-files-prod.s3.amazonaws.com/4XpfBqzvrWDKKPiQ1J3Gyt https://cassyni.com/events/Ar8FFrpJLFCbq8RUkwYTWm/seminar/qa https://cassyni.com/slides/outline/Ar8FFrpJLFCbq8RUkwYTWm https://cassyni.com/events/Ar8FFrpJLFCbq8RUkwYTWm/abstract https://cassyni-user-files-prod.s3.amazonaws.com/EkNpdC99YLa2nKkKpRzGWi https://cassyni.com/events/Ar8FFrpJLFCbq8RUkwYTWm?videoPreview=1 Utilization of Large Eddy Simulations in Industrial Research & Developmentnohttps://cassyni.com/events/Ar8FFrpJLFCbq8RUkwYTWm?videoPreview=12025-10-06T15:00:00+00:003671.04Sci-Fi-TurboComputational Fluid Dynamics (CFD) using Reynolds Averaged Navier Stokes (RANS) based closure modeling has become a cornerstone of aerodynamic analysis, driven by advancements in high-performance computing. While efficient algorithms for rapid steady-state modeling have matured RANS simulations over the past two decades, most efforts have focused on attached flow conditions, which represent less than 25% of the total aerodynamics development effort. As CFD expands beyond design and optimization towards Certification and Qualification by Analysis, there's growing interest in high-fidelity numerical modeling for flight envelope regions characterized by large separated flows. These flows are significantly influenced by large-scale turbulence dynamics, and most RANS closures have limited success in such conditions. While this has led some manufacturers to incorporate scale-resolving simulations, widespread use of technologies like Wall Modeled Large Eddy Simulations (WMLES) remains limited due to the high computational cost and lack of automation in LES-quality grid generation for complex geometries. This talk will demonstrate that automated Cartesian octree grid generation and an accurate high-Reynolds number viscous immersed boundary treatment for complex geometries can effectively address the grid generation bottleneck. Furthermore, carefully designed non-dissipative discretizations, implemented via a highly optimized software stack leveraging modern GPUs, can enable accurate LES at a computational cost comparable to RANS simulations using existing commercial software. The presentation will showcase detailed LES investigations of engineering problems involving separated flow aerodynamics and aeroacoustics. These simulations were performed on modest compute resources using 2 to 8 general-purpose GPU cards like the Nvidia RTX-4090 and Nvidia L40S. This breakthrough has the potential to enable LES utilization for a wide range of off-design flight characteristics without requiring access to DOE-class supercomputers.https://cassyni-user-files-prod.s3.amazonaws.com/EkNpdC99YLa2nKkKpRzGWi https://cassyni.com/events/V89E5nGbyYcdzTUNcvaKWD/abstract https://cassyni-user-files-prod.s3.amazonaws.com/UiSjQCrWCfrt6PQKYJttTg https://cassyni.com/events/Lj7xJAGgWmCeq87uZ5FGHK/abstract https://cassyni-user-files-prod.s3.amazonaws.com/UMrHM89WKKhg8WHmer5XaW https://cassyni.com/events/XbPFKCWEAqP8MPwwAcUxE9/seminar/qa https://cassyni.com/slides/outline/XbPFKCWEAqP8MPwwAcUxE9 https://cassyni.com/events/XbPFKCWEAqP8MPwwAcUxE9/abstract https://cassyni-user-files-prod.s3.amazonaws.com/7aJ7JMERpceDeyRq8gAxar https://cassyni.com/events/XbPFKCWEAqP8MPwwAcUxE9?videoPreview=1 JIVP Series: Evaluating Visual Quality in Immersive Multimedia: Bridging Human Perception and Machine Intelligencenohttps://cassyni.com/events/XbPFKCWEAqP8MPwwAcUxE9?videoPreview=12025-04-03T12:00:00+00:003264.04Journal on Image and Video ProcessingThe rapid evolution of immersive multimedia technologies, such as stereoscopic 3D, virtual reality (VR), light field, and point cloud, has introduced new challenges in evaluating perceptual visual quality in immersive environments. This talk explores the dual perspective of visual quality assessment, combining subjective methods, such as user studies and psychophysical experiments, with objective models designed to predict human perception in immersive environments automatically. We will highlight recent advances in AI-driven analysis, e.g., the use of graph network models, to enhance the accuracy and robustness of quality predictions. By integrating human perceptual factors into machine intelligence, we aim to develop more effective frameworks for assessing immersive visual quality and improving perceptual quality. We hope this talk will inspire insightful discussions and help shape future directions in immersive multimedia quality assessment.https://cassyni-user-files-prod.s3.amazonaws.com/7aJ7JMERpceDeyRq8gAxar https://cassyni.com/events/U8r1zQyZ6dWVKheNWx6zhK/seminar/qa https://cassyni.com/slides/outline/U8r1zQyZ6dWVKheNWx6zhK https://cassyni.com/events/U8r1zQyZ6dWVKheNWx6zhK/abstract https://cassyni-user-files-prod.s3.amazonaws.com/6NMmvZ51CKdTUaDKaN8qQa https://cassyni.com/events/U8r1zQyZ6dWVKheNWx6zhK?videoPreview=1 Attracting SDG Research to your Journalnohttps://cassyni.com/events/U8r1zQyZ6dWVKheNWx6zhK?videoPreview=12025-06-19T14:00:00+00:002821.96Topics at the heart of our communityThe 17 Sustainable Development Goals (SDGs) set out a blueprint for a sustainable future on earth, covering the social, health, economic and environmental issues that we urgently need to address to allow future generations to thrive. The SDGs represent rapidly growing areas of high impact research, and the Goals are relevant to almost all subject disciplines. Nicola Jones, Director, Springer Nature SDG Programme, will lead a discussion about why publishing SDG-related research is beneficial for traditional measures of journal success, and why this research is so important in helping to ensure a sustainable future. Join us and find out what steps editors can take to attract SDG-related research to their journal. Marco Cordani, Associate Editor for Cell Communication and Signaling, and Joshua Bayliss, Senior Publisher for Radiation and Environmental Biophysics, will also present case studies on their approaches to welcoming more SDG research to their journals.  https://cassyni-user-files-prod.s3.amazonaws.com/6NMmvZ51CKdTUaDKaN8qQa https://cassyni.com/events/xUzYBgjqNA9nqwrdvBrpM/seminar/qa https://cassyni.com/slides/outline/xUzYBgjqNA9nqwrdvBrpM https://cassyni.com/events/xUzYBgjqNA9nqwrdvBrpM/abstract https://cassyni-user-files-prod.s3.amazonaws.com/HcLir2VoDTKSvr3pqrFmLa https://cassyni.com/events/xUzYBgjqNA9nqwrdvBrpM?videoPreview=1 Intensionality of consequence and identity of proofs in Prawitz’s Theory of Groundsnohttps://cassyni.com/events/xUzYBgjqNA9nqwrdvBrpM?videoPreview=12025-04-16T14:00:00+00:005236.04Logica UniversalisI discuss two possible ways for dealing with a constructive, proof based notion of logical consequence. The first, qualified as extensional, amounts to the idea that a given proof-structure is justifiable under every interpretation of the non-logical terminology it involves. The second, qualified as intensional, requires on the contrary that the given proof-structure be justified independently of its non-logical meaning. Contrarily to the extensional approach, the intensional account calls for a prior treatment of the notion of identity of proofs. Identity can be in turn addressed in an extensional or intensional way. Although these issues are obviously of a more general interest, I investigate them in a framework which seems to me to be particularly well-suited for the purpose, i.e., Prawitz’s (non-monotonic) Theory of Grounds.https://cassyni-user-files-prod.s3.amazonaws.com/HcLir2VoDTKSvr3pqrFmLa https://cassyni.com/slides/outline/EJh6hGrrop11gXBfcGkaxV https://cassyni.com/events/EJh6hGrrop11gXBfcGkaxV/abstract https://cassyni-user-files-prod.s3.amazonaws.com/BMv9QFUq6GB1pECGkgULPp https://cassyni.com/slides/outline/Gmw7vh6V16mW3TfE9xfDgR https://cassyni.com/events/Gmw7vh6V16mW3TfE9xfDgR/abstract https://cassyni-user-files-prod.s3.amazonaws.com/DsAym2erM79biJmapyzAdk https://cassyni.com/events/Gmw7vh6V16mW3TfE9xfDgR?videoPreview=1 19th international Biometals Webinars iBWsnohttps://cassyni.com/events/Gmw7vh6V16mW3TfE9xfDgR?videoPreview=12025-10-07T13:00:00+00:005190.68BioMetalsThe seminar addresses critical aspects of iron metabolism and iron-sulfur (Fe-S) cluster biogenesis, emphasizing their fundamental roles in biology and human health. The first part focuses on iron acquisition and homeostasis in green algae, particularly Dunaliella species, which exhibit remarkable resilience to iron deficiency. Genomic, transcriptomic, and proteomic analyses reveal multiple iron assimilation pathways, including a novel transferrin-dependent complex associated with multicopper oxidase and P130B proteins, likely facilitating high-affinity iron uptake. Iron sparing mechanisms are demonstrated by the downregulation of ferredoxin and compensatory upregulation of flavodoxin and flavin biosynthesis, collectively reducing cellular iron demand. Structural studies using cryo-electron microscopy show remodeling of photosystem I under iron limitation, with increased antenna size mediated by a unique light-harvesting protein (TD1), suggesting adaptive optimization of photosynthetic efficiency. The second part elucidates the molecular mechanism of Fe-S cluster assembly by the ISC machinery, highlighting the sequential formation of a ferrous iron–persulfide intermediate on the scaffold protein ISCU. Spectroscopic and biochemical assays characterize this intermediate and its conversion to the [2Fe-2S] cluster via protein dimerization. A key regulatory insight is the competitive interaction between frataxin and ferredoxin for binding to the NFS1-ISCU complex, modulating persulfide reduction and cluster assembly rates. This antagonistic regulation has biomedical relevance, as imbalances contribute to Friedreich ataxia pathology; experimental modulation of ferredoxin levels in a Drosophila model partially rescues disease phenotypes. Together, these findings advance understanding of iron metabolism adaptations in photosynthetic organisms and refine mechanistic and regulatory models of Fe-S cluster biogenesis with implications for therapeutic strategies.https://cassyni-user-files-prod.s3.amazonaws.com/DsAym2erM79biJmapyzAdk https://cassyni.com/slides/outline/9ND4ESPcRETzHRUKbo3bEM https://cassyni.com/events/9ND4ESPcRETzHRUKbo3bEM/abstract https://cassyni-user-files-prod.s3.amazonaws.com/XEgTGrscFFhCoXqeSJztGv https://cassyni.com/events/9ND4ESPcRETzHRUKbo3bEM?videoPreview=1 Water Diplomacynohttps://cassyni.com/events/9ND4ESPcRETzHRUKbo3bEM?videoPreview=12025-04-16T07:30:00+00:002732.04Cambridge PrismsNo abstracthttps://cassyni-user-files-prod.s3.amazonaws.com/XEgTGrscFFhCoXqeSJztGv https://cassyni.com/events/QBEquW54YZBSLa9psUpzPw/seminar/qa https://cassyni.com/slides/outline/QBEquW54YZBSLa9psUpzPw https://cassyni.com/events/QBEquW54YZBSLa9psUpzPw/abstract https://cassyni-user-files-prod.s3.amazonaws.com/RKuM2SfdhN5egVkya65KzW https://cassyni.com/events/QBEquW54YZBSLa9psUpzPw?videoPreview=1 The diversity of ignorance and the ignorance of diversity: origins and implications of “shadow diversity” for conservation biology and extinctionnohttps://cassyni.com/events/QBEquW54YZBSLa9psUpzPw?videoPreview=12026-06-23T14:00:00+00:001973.12Cambridge PrismsBiodiversity shortfalls and taxonomic bias can lead to inaccurate assessment of conservation priorities. Previous literature has begun to explore practical reasons why some species are discovered sooner or are better researched than others. However, the deeper socio-cultural causes for undiscovered and neglected biodiversity, and the value of collectively analysing species at risk of unrecorded, or “dark”, extinction, are yet to be fully examined. Here, we argue that a new label (we propose “shadow diversity”) is needed to shift our perspective from biodiversity shortfalls to living, albeit unknown, species. We suggest this linguistic shift imparts intrinsic value to these species, beyond scientific gaze and cultural systems. We review research on undiscovered, undetected and hidden biodiversity in the fields of conservation biology, macroecology and genetics. Drawing on philosophy, geography, history and sociology, we demonstrate that a range of socio-cultural factors (funding, education and historical bias) combine with traditional, practical impediments to limit species discovery and detection. We propose using a spectrum of shadow diversity which enables a complex, non-binary and comprehensive approach to biodiversity unknowns. Shadow diversity holds exciting potential as a tool to increase awareness, appreciation and support for the conservation of traditionally less studied wildlife species and sites, from soil microbes to less charismatic habitat fragments. We advocate for a shift in how the conservation community and wider public see biodiversity and an increase in popular support for conserving a wider range of life forms. Most importantly, shadow diversity provides appropriate language and conceptual frameworks to discuss species absent from conservation assessment and at potential risk of dark extinction.https://cassyni-user-files-prod.s3.amazonaws.com/RKuM2SfdhN5egVkya65KzW https://cassyni.com/slides/outline/VcNVR2BqNbGqTyjct74tMK https://cassyni.com/events/VcNVR2BqNbGqTyjct74tMK/abstract https://cassyni-user-files-prod.s3.amazonaws.com/KAhavmNaaBZCjh24YL2Tgi https://cassyni.com/events/VcNVR2BqNbGqTyjct74tMK?videoPreview=1 Patterns of Turbulencenohttps://cassyni.com/events/VcNVR2BqNbGqTyjct74tMK?videoPreview=12025-05-01T11:00:00+00:003936.96The Edinburgh Fluid Dynamics Group (EFDG)The greatest mystery in fluid dynamics is probably transition to turbulence. The simplest shear flow, plane Couette flow -- the flow between parallel plates moving at different velocities -- undergoes transition to turbulence, despite being linearly stable for all Reynolds numbers. Nor does this transition take place via turbulence growing progressively stronger as the Reynolds number is increased. Instead, the transitional flow takes the form of a remarkable steady pattern of alternating wide turbulent and laminar bands. Numerical simulations of the Navier-Stokes equations display a rich variety of variants of these patterns, including spatio-temporal intermittency, branching and travelling states, and localized states analogous to spots. Strong flow along the band boundaries play a symbiotic role with the turbulence. As the Reynolds number is decreased, the turbulent bands become isolated and increasingly sparse. Complete laminarization takes place via their disappearance characterized by the 2D directed percolation scenario. https://cassyni-user-files-prod.s3.amazonaws.com/KAhavmNaaBZCjh24YL2Tgi https://cassyni.com/events/S9qG6EfAJPQCSHS4ESgvpV/seminar/qa https://cassyni.com/slides/outline/S9qG6EfAJPQCSHS4ESgvpV https://cassyni.com/events/S9qG6EfAJPQCSHS4ESgvpV/abstract https://cassyni-user-files-prod.s3.amazonaws.com/7ptymvBwv6nceLUhTUBYUe https://cassyni.com/events/S9qG6EfAJPQCSHS4ESgvpV?videoPreview=1 “A Woman’s Labour” – interdisciplinary provocations for healthier and more equitable futuresnohttps://cassyni.com/events/S9qG6EfAJPQCSHS4ESgvpV?videoPreview=12025-08-20T15:00:00+00:003700.56Women's Health“The future in research is transdisciplinary. Addressing the issue of a woman’s labour as related to care, curates an assemblage of voices, approaches, and systems of thinking that address the ever so prominent need for more hopeful avenues towards equitable futures. The intersectional and multifaceted concept of gendered labour connects us all in questioning, challenging, and recalibrating theories practices and policies. We invite you to join our provocations and actively participate in shaping knowledge that is necessary for each and all of us, as individuals, communities, and society.” - Dr Liana Psarologaki, Guest Editor of the Special Collectionhttps://cassyni-user-files-prod.s3.amazonaws.com/7ptymvBwv6nceLUhTUBYUe https://cassyni.com/slides/outline/7squNwik4SuRfETLW1gDeu https://cassyni.com/events/7squNwik4SuRfETLW1gDeu/abstract https://cassyni-user-files-prod.s3.amazonaws.com/mGAdTm5pZagYz6LxGsQEJ https://cassyni.com/slides/outline/9rSKZgJqpH8BkwjZryYA5T https://cassyni.com/events/9rSKZgJqpH8BkwjZryYA5T/abstract https://cassyni-user-files-prod.s3.amazonaws.com/6GjXoVQcCAVocFdgV3UCeS https://cassyni.com/events/9rSKZgJqpH8BkwjZryYA5T?videoPreview=1 Charleston In Between: Opening Keynotenohttps://cassyni.com/events/9rSKZgJqpH8BkwjZryYA5T?videoPreview=12025-07-08T11:45:00+00:002666.08Part of the nonprofit Annual Reviews organization Image credit: [Florian Wehde (Unsplash)](https://unsplash.com/photos/city-buildings-near-body-of-water-during-daytime-1uWanmgkd5g).https://cassyni-user-files-prod.s3.amazonaws.com/6GjXoVQcCAVocFdgV3UCeS https://cassyni.com/events/EnvN2Wn6CrfDA3SusTF9ob/seminar/qa https://cassyni.com/slides/outline/EnvN2Wn6CrfDA3SusTF9ob https://cassyni.com/events/EnvN2Wn6CrfDA3SusTF9ob/abstract https://cassyni-user-files-prod.s3.amazonaws.com/nk4ofYBq6k62ReiWMA25C https://cassyni.com/events/RAbJE8PtEC9Qi3UQsQK2iH/seminar/qa https://cassyni.com/slides/outline/RAbJE8PtEC9Qi3UQsQK2iH https://cassyni.com/events/RAbJE8PtEC9Qi3UQsQK2iH/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Bex2zqy9im1UAJhxkj4jP4 https://cassyni.com/events/RAbJE8PtEC9Qi3UQsQK2iH?videoPreview=1 Vitamin D Supplementation in Women’s Health Across the Lifespan: Impacts on Disease Biomarkers, Oxidative Stress, and Adipokinesnohttps://cassyni.com/events/RAbJE8PtEC9Qi3UQsQK2iH?videoPreview=12025-09-26T14:00:00+00:002826.92Women's Health“I believe now is the moment to deepen our understanding of Vitamin D’s role in women’s health, because the research we share today will shape the lives of generations tomorrow. Vitamin D impacts far more than bone health; it influences disease biomarkers, oxidative stress balance, and adipokine regulation, factors that profoundly shape a woman’s vitality and longevity. We launched this Special Collection to spotlight the growing body of scientific evidence on the role of Vitamin D sufficiency in disease prevention and management throughout a woman's life course. This Special Collection is a call to action for researchers, clinicians, and public health experts worldwide to contribute with impactful research. Together, we can enhance the global research evidence base and translate findings into strategies that enhance women’s health at every stage of life.” - Dr Fatme Al Anouti, Guest Editor of the Special Collectionhttps://cassyni-user-files-prod.s3.amazonaws.com/Bex2zqy9im1UAJhxkj4jP4 https://cassyni.com/slides/outline/2Sjsz47rdmk864fj6mWbaM https://cassyni.com/events/2Sjsz47rdmk864fj6mWbaM/abstract https://cassyni-user-files-prod.s3.amazonaws.com/A98uMwus85XDAoq8VbPejQ https://cassyni.com/events/2Sjsz47rdmk864fj6mWbaM?videoPreview=1 Perturbation Analysis Of Stationary Manifolds Governed By Nonlinear Friction Characteristics In Automotive Drivelinesnohttps://cassyni.com/events/2Sjsz47rdmk864fj6mWbaM?videoPreview=12025-06-25T08:00:00+00:00817.44NODYSTorque splitting strategies adopting clutch units are increasingly popular in modern powertrains to improve vehicle dynamics. A significant drawback, however, is represented by the possible occurrence of self-excited vibrations. Therefore, a nonlinear multibody model of a full driveline has been developed to analyze these issues, validating the results with experimental data. The non-stationary behaviour of the driveline is found to be strongly dependent on the nonlinear friction characteristics. Stability maps identified negative friction gradients of the clutch torque splitter as responsible for unstable oscillations, while modal analysis revealed a dominant localization of some modes within the whole transmission. Nonlinear analysis of a minimal model of the transmission revealed the existence of stable limit cycles due to a super-critical Hopf bifurcation. Their amplitude is governed by the magnitude of the equilibrium slip speed inside the clutch unit.https://cassyni-user-files-prod.s3.amazonaws.com/A98uMwus85XDAoq8VbPejQ https://cassyni.com/slides/outline/DK1B16MQHqvbcLVkiJkHXB https://cassyni.com/events/DK1B16MQHqvbcLVkiJkHXB/abstract https://cassyni-user-files-prod.s3.amazonaws.com/4QEPhSY15P2aiaxgXk4n1c https://cassyni.com/events/DK1B16MQHqvbcLVkiJkHXB?videoPreview=1 Boost Your Productivity with AInohttps://cassyni.com/events/DK1B16MQHqvbcLVkiJkHXB?videoPreview=12023-10-17T23:00:00+00:003340.6Business SchoolThe seminar addresses the escalating "digital debt" within organizations, where excessive time spent on administrative tasks, emails, and meetings hinders innovation. This challenge is met with a positive outlook on artificial intelligence, as 75% of employees express willingness to delegate mundane tasks to AI, and managers foresee enhanced productivity rather than workforce reduction. The presentation introduces Microsoft 365 Copilot, an AI digital assistant developed with GPT-4 and seamlessly integrated into Microsoft 365 applications. This tool is part of a broader ecosystem of Microsoft Copilots, extending to Dynamics 365, Power Platform, GitHub, and Security operations. Its underlying architecture, the Copilot System, combines Microsoft 365 Apps, the Microsoft Graph (comprising emails, files, meetings, chats, and calendar data), and a large language model (LLM). A critical process called "grounding" refines user prompts by incorporating specific business content and context from the Microsoft Graph, ensuring relevant and actionable responses. Emphasis is placed on robust security, compliance, and privacy frameworks; Copilot inherits existing organizational policies and adheres to 19 AI-specific global standards. User data remains within the organization’s Office 365 tenant and is not used to train the LLM. Copilot's capabilities include summarising diverse content (emails, chats, documents, video transcripts), performing market research, analysing data, recommending actions, and generating various forms of content with personalised tones. The system also supports external plug-ins for integration with third-party data sources. Early adoption shows high user satisfaction, with 83% of users unwilling to revert to working without Copilot. This technology underscores the importance of "prompting" as a new critical skill, akin to natural language programming, and is anticipated to drive significant productivity gains and foster greater inclusivity in diverse work environments.https://cassyni-user-files-prod.s3.amazonaws.com/4QEPhSY15P2aiaxgXk4n1c https://cassyni.com/slides/outline/CKhxuj4MQvpSwafkcLGxiH https://cassyni.com/events/CKhxuj4MQvpSwafkcLGxiH/abstract https://cassyni-user-files-prod.s3.amazonaws.com/QvPzG95AR7gfSbXxZJ4Syc https://cassyni.com/events/CKhxuj4MQvpSwafkcLGxiH?videoPreview=1 The China business tech scenenohttps://cassyni.com/events/CKhxuj4MQvpSwafkcLGxiH?videoPreview=12020-11-04T00:00:00+00:003557.4Business SchoolThis abstract examines the dynamic evolution of China's business technology scene, driven by its re-emergence as a global economic power and a strategic national shift towards high-tech leadership. Since 1978, China has grown to represent approximately 18% of the world's economy, with initiatives like the One Belt One Road and Digital Silk Road actively expanding its technological influence and standards internationally. The analysis reveals a domestic technology market marked by both significant opportunities and complex challenges. While few Chinese brands achieve global recognition (Huawei being a notable exception), the internal market is robust, with an online population of approximately 60% and rapidly developing regional tech hubs. China is at the forefront of global advancements in Artificial Intelligence, with a national plan to lead by 2030, and 5G deployment, operating ahead of the UN schedule. Key industries demonstrate remarkable growth: e-commerce comprises half of the global market, and FinTech boasts nearly half of the world's privately held "unicorn" companies. However, the sector faces increasing labor costs, negative international perceptions regarding data security, and substantial trade frictions. Policies such as "Made in China 2025," which mandates increased domestic content for core components, and concerns over data sharing (e.g., ByteDance/TikTok), lead to tariffs and non-tariff barriers. Foreign companies engaging in the Chinese market must navigate these regulatory demands and strong local competition, even as the market's vast untapped potential and rapid technological development continue to attract investment.https://cassyni-user-files-prod.s3.amazonaws.com/QvPzG95AR7gfSbXxZJ4Syc https://cassyni.com/events/TdqKTYdWRUuu4ywyR6DfSD/seminar/qa https://cassyni.com/events/TdqKTYdWRUuu4ywyR6DfSD/abstract https://cassyni-user-files-prod.s3.amazonaws.com/3XKXiyyGoAsRVyCbaXntJJ https://cassyni.com/events/TdqKTYdWRUuu4ywyR6DfSD?videoPreview=1 Seeing Oneself Anew: How Trans Experiences of Authenticity Emerge Through Memoir and Storytellingnohttps://cassyni.com/events/TdqKTYdWRUuu4ywyR6DfSD?videoPreview=12025-10-16T18:00:00+00:002938.08Lived Places PublishingWhat does it mean to reconsider the stories one has told about oneself? How do these stories evolve with the hindsight of continued lived experience? In this session, **Jessye DeSilva** focuses on how the practice of engaging in sustained close reading of lyrical writing offers insights into one’s own life. She examines how she's used her own songwriting as the tether to tell the story of her gender identity as a constellation of sensations that emerge through her music-making. This session examines how memoir and storytelling help us revisit and repair the stories we tell ourselves and others, with a focus on how trans experiences of authenticity emerge through the vulnerability of art-making praxis.https://cassyni-user-files-prod.s3.amazonaws.com/3XKXiyyGoAsRVyCbaXntJJ https://cassyni.com/events/NhMGziAG2uNbcZfHv1AJ2R/abstract https://cassyni-user-files-prod.s3.amazonaws.com/3HktWPhfzFsccvFGGrK7pa https://cassyni.com/slides/outline/HksEXsh1eKqaDTwwuXTJJH https://cassyni.com/events/HksEXsh1eKqaDTwwuXTJJH/abstract https://cassyni-user-files-prod.s3.amazonaws.com/FX3wj4midd5g6XMTxa2ipW https://cassyni.com/events/HksEXsh1eKqaDTwwuXTJJH?videoPreview=1 Self-induced microwave sink via plasma generationnohttps://cassyni.com/events/HksEXsh1eKqaDTwwuXTJJH?videoPreview=12025-06-16T07:00:00+00:001279.04ETOPIMRecently, various methods for sub-wavelength wave focusing have been proposed [1, 2]. In optics, this involves placing nanoparticles at the focal spot to act as sinks, enabling the excitation of Localized Surface Plasmons (LSPs). This leads to wave absorption via Coherent Perfect Absorption (CPA), achieving subwavelength focusing [1, 2] We introduce a ”self-induced” sink that does not require an initial sink at the focal point. Instead, the converging wave itself generates it. Inspired by recent works showing that time reversal can focus microwaves intensely enough to ionize gas and create plasma [3], we numerically demonstrate that plasma formed by microwave focusing can act as an electromagnetic sink. The CPA condition is met via LSP excitation, which occurs in the microwave regime due to the low plasma frequency [4]. The nonlinear nature of plasma breakdown enables this self-induced sink.https://cassyni-user-files-prod.s3.amazonaws.com/FX3wj4midd5g6XMTxa2ipW https://cassyni.com/slides/outline/W75Lgxs8cmgS79Bkst22SR https://cassyni.com/events/W75Lgxs8cmgS79Bkst22SR/abstract https://cassyni-user-files-prod.s3.amazonaws.com/vwpgGZ59WwqRCgDbVqzGv https://cassyni.com/events/W75Lgxs8cmgS79Bkst22SR?videoPreview=1 Negative capacitors with Floquet engineeringnohttps://cassyni.com/events/W75Lgxs8cmgS79Bkst22SR?videoPreview=12025-06-18T03:00:00+00:001817.48ETOPIMNegative capacitors have been a long-sought goal in electromagnetics to break fundamental limits, such as the Bode-Fano limit in matching networks or the Chu limit in antennas. Such capacitors can be realized through non-Foster circuits based on transistors, however with problems on stability and noise. Recently, several works have explored the possibility of breaking fundamental limits through time modulation, to take advantage of the superior noise performance of such networks compared to transistor networks. However, such works have focused on expanding the bandwidth of specific structures, without addressing the fundamental question of realizing negative capacitors that would provide a general solution for breaking bounds in various scenarios. In this work, we present an approach for realizing negative capacitors based on periodic time modulation. The proposed approach realizes networks with a negative-residue impedance pole at zero frequency, as should be the case with negative capacitors. We also show that the proposed approach satisfies the fundamental capacitor equation Q = CV with C < 0 for excitation with static voltages. In other words, we show that application of a static voltage V results in the induction of a negative charge Q, as would be expected in a negative capacitor. We demonstrate this approach in various scenarios, including excitation with static and harmonic sources. Furthermore, we analyze the use of proposed approach in matching of capacitive loads and show how it significantly improves the matching bandwidth compared to the Bode-Fano limit. Our work addresses a fundamental question in electromagnetics and opens possibilities for improving the performance of systems in electromagnetics and other disciplines. https://cassyni-user-files-prod.s3.amazonaws.com/vwpgGZ59WwqRCgDbVqzGv https://cassyni.com/slides/outline/YaKMvP6kp4SvU5fKRZvfAM https://cassyni.com/events/YaKMvP6kp4SvU5fKRZvfAM/abstract https://cassyni-user-files-prod.s3.amazonaws.com/ApchWaCX3kv1bxrF1692bx https://cassyni.com/events/YaKMvP6kp4SvU5fKRZvfAM?videoPreview=1 Harnessing multiple-scattering electromagnetic environments for wave-control via in-situ adjoint optimizationnohttps://cassyni.com/events/YaKMvP6kp4SvU5fKRZvfAM?videoPreview=12025-06-19T01:00:00+00:002508.88ETOPIMWe develop an in-situ time- and energy-efficient adjoint optimization (AO) methodology for the manipulation of wave scattering in multiple scattering systems and demonstrate wave-driven functionalities like targeted channel emission, coherent perfect absorption and camouflage. Our paradigm leverages the highly multi-path nature of these complex environments which dramatically amplifies small local system variations since the wave is repeatedly scattered by these AO-informed perturbations. Our approach can find immediate application to in-door wireless technologies while it can also be incorporated into a variety of wave-based frameworks including imaging, power electronic and optical neural networks. https://cassyni-user-files-prod.s3.amazonaws.com/ApchWaCX3kv1bxrF1692bx https://cassyni.com/slides/outline/8NYketQ3JdK2JPuUVndMk1 https://cassyni.com/events/8NYketQ3JdK2JPuUVndMk1/abstract https://cassyni-user-files-prod.s3.amazonaws.com/9gLHyejxvrAvDEXsxtHawp https://cassyni.com/events/8NYketQ3JdK2JPuUVndMk1?videoPreview=1 The role of plant–soil–microbe interactions on nitrogen cycling under drought and warming in grasslandsnohttps://cassyni.com/events/8NYketQ3JdK2JPuUVndMk1?videoPreview=12025-07-09T12:00:00+00:00922.04NoneAn accurate understanding of the plant–soil biogeochemical cycles is crucial to model the impacts of global change in grasslands. However, further exploration is needed to disentangle the plant–microbe interaction under warming and drought. In this study, we increase temperature and water deficit in 240 pots, considering six different grassland species (2 forbs, 2 grasses, and 2 N-fixers) and two different soil types (coming from intensive and extensive management practices). By analyzing N content and biomass production in the soil, microbial, belowground, and aboveground compartments, we study potential interactions between the plant–microbial system under the different conditions. Preliminary results indicate that plants growing in intensively managed soils are only more productive under control and warming treatments, becoming a concerning N source otherwise. In contrast, plant–soil systems developing on extensively managed soils remain more stable under warming and drought. Plants showed to be more negatively impacted by drought, whereas microbes were more negatively impacted by warming. In addition, plant and microbial N stocks showed a negative correlation in grasses but a positive one in forbs and N-fixer species, suggesting contrasting plant–microbe interactions. These findings will help better incorporate the role of microbes in the N cycling, better understand the impacts of future conditions, and plan management strategies accordingly. https://cassyni-user-files-prod.s3.amazonaws.com/9gLHyejxvrAvDEXsxtHawp https://cassyni.com/events/3S4iC3vnv3mzuJC8VJvN1s/seminar/qa https://cassyni.com/slides/outline/3S4iC3vnv3mzuJC8VJvN1s https://cassyni.com/events/3S4iC3vnv3mzuJC8VJvN1s/abstract https://cassyni-user-files-prod.s3.amazonaws.com/PLcXB3DV2N6eBDRujykxeA https://cassyni.com/events/3S4iC3vnv3mzuJC8VJvN1s?videoPreview=1 Challenges in Formal Analysis of Resilience: Capturing the Tradeoff Between the Chance of Failure and the Cost of Successnohttps://cassyni.com/events/3S4iC3vnv3mzuJC8VJvN1s?videoPreview=12025-07-30T14:00:00+00:004662.04Logica UniversalisThere is growing interest in the concept of Resilience and balancing resources spent on increasing resilience at the expense of efficiency. From a logical perspective we are interested in formally representing key features of resilience, design principles supporting resilience, and methods to verify system resilience given a formal (in some logic) representation. As background and motivation we review notions of resilience in the context of a variety of systems–digital, natural, societal–along with some examples. We identify some key features of resilience and discuss challenges in developing formal models. After a review of commonly used modeling formalisms and verification problems, we propose an extension that allows modeling resilience features and expressing associated verification problems. We further connect resilience with chance and money by comparing resilience features to principles expressed by the Zurich axioms.https://cassyni-user-files-prod.s3.amazonaws.com/PLcXB3DV2N6eBDRujykxeA https://cassyni.com/slides/outline/3vjwMN6CksFpimBeHR3LC5 https://cassyni.com/events/3vjwMN6CksFpimBeHR3LC5/abstract https://cassyni-user-files-prod.s3.amazonaws.com/YZeRZS1iWBV52oQVhN6upJ https://cassyni.com/events/3vjwMN6CksFpimBeHR3LC5?videoPreview=1 Sniffing out interspecies interactions in the human nasal microbiotanohttps://cassyni.com/events/3vjwMN6CksFpimBeHR3LC5?videoPreview=12025-12-10T01:00:00+00:001972.92Microbiome Virtual International ForumThe human nasal microbiota plays a critical role in modulating colonization and infection by pathobionts such as Staphylococcus aureus and Streptococcus pneumoniae, which are significant contributors to global morbidity and mortality, including antimicrobial-resistant infections. Nasal colonization by these bacteria is a well-established risk factor for invasive disease, yet only subsets of individuals harbor these organisms, suggesting complex host-microbe and microbe-microbe interactions govern colonization dynamics. This study employs human nasal epithelial organoids (HNOs) differentiated at an air-liquid interface to model bacterial colonization under physiologically relevant conditions (34 °C), enabling mechanistic investigation of microbial interactions and epithelial responses. Monocolonization experiments demonstrate that S. aureus, S. pneumoniae, and Dolosigranulum pigrum—a common nasal commensal negatively associated with S. aureus colonization—can establish stable populations within the mucus layer without overt cytotoxicity, except for occasional epithelial irritation by S. aureus. Cytokine profiling reveals both general innate immune activation and species-specific responses, including IL-18 induction by live S. aureus and suppression of CXCL10 by D. pigrum. Using transposon sequencing, D-alanine aminotransferase (dat) was identified as a critical S. aureus fitness factor for nasal colonization, with disruption causing a >3,000-fold colonization defect on HNOs that is chemically complemented by exogenous D-alanine. These findings highlight the importance of bacterial metabolic pathways in colonization fitness within the nasal niche. The HNO model also facilitates testing of multi-species interactions and phage-mediated bacterial killing, offering a promising platform to identify microbial strains, compounds, and phages that could inform novel preventive and therapeutic strategies against nasal pathobiont infections.https://cassyni-user-files-prod.s3.amazonaws.com/YZeRZS1iWBV52oQVhN6upJ https://cassyni.com/events/GGx3WTGKjK6gcSRTFmc4LD/seminar/qa https://cassyni.com/slides/outline/GGx3WTGKjK6gcSRTFmc4LD https://cassyni.com/events/GGx3WTGKjK6gcSRTFmc4LD/abstract https://cassyni-user-files-prod.s3.amazonaws.com/YDyfNEAf8AoSpjC6NVFfeN https://cassyni.com/events/GGx3WTGKjK6gcSRTFmc4LD?videoPreview=1 The historical role of system dynamics modelling in understanding and supporting integrated natural resource managementnohttps://cassyni.com/events/GGx3WTGKjK6gcSRTFmc4LD?videoPreview=12025-11-12T14:00:00+00:001901.96Cambridge PrismsThis talk will chart the history of how system dynamics modelling (SDM) has evolved in the field of natural resource management from a relatively niche subject to a tool of increasing practical relevance and impact, and encourages practitioners to continue this trend with some suggestions for further promoting SDM for natural resource impact assessment and policy support. It not only traces key developments and thematic shifts but also advocates for SDM as a critical approach for addressing today’s complex and interconnected resource challenges. Starting in the 1970s with the Limits to Growth and a burgeoning environmental movement, the path of SDM applications for natural resource management and assessment is outlined. Models turned in the 1980s to a dominantly ecological focus, considering lake ecosystems and predator–prey dynamics, and tended to be largely single-sector focused, with feedbacks and complexity being used to describe sectoral system dynamics. Since about 2000,SDMhas been applied to broader and more integrated natural resource systems and has frequently included stakeholders and participatory methods to co-develop models for increasingly practical applications and support. The emergence of the water–energy–food nexus around 2010 lends itself to SDM studies, including the assessment of climatic and socio-economic futures on resources supply, demand and security, and the impact of policy implementation across whole systems. Stakeholder engagement, participatory modelling, online tools and interfaces, machine learning and targeted, policy facing studies are opportunities to further promote SDM and systems thinking for natural resource management in an increasingly complex and interconnected world, enhancing its practical impact.https://cassyni-user-files-prod.s3.amazonaws.com/YDyfNEAf8AoSpjC6NVFfeN https://cassyni.com/slides/outline/AqpPzw9YuH1cDaBDercGLm https://cassyni.com/events/AqpPzw9YuH1cDaBDercGLm/abstract https://cassyni-user-files-prod.s3.amazonaws.com/mxFuzavS2Z6MeXN2m3rfp https://cassyni.com/events/AqpPzw9YuH1cDaBDercGLm?videoPreview=1 The colorectal cancer microbiome: exploring its value for diagnosis and preventionnohttps://cassyni.com/events/AqpPzw9YuH1cDaBDercGLm?videoPreview=12026-05-12T13:00:00+00:002116.92Microbiome Virtual International ForumThe gut microbiome plays a crucial role in colorectal cancer (CRC) development and progression, indicating its potential for diagnosis and prevention. This study presents a large-scale meta-analysis of nearly 7,000 human gut microbiome samples (from both 16S amplicon and shotgun metagenomic sequencing) and a complementary meta-analysis of 1,822 CRC tissue samples. A robust, universal CRC microbiome signature was identified, consistent across sequencing approaches and patient age-of-onset, though biogeographic stratification was observed at subspecies and strain levels. Analysis of virulence factors across 800 *Fusobacterium* genomes highlighted a focal clade (*F. nucleatum*/*F. periodonticum*) associated with both CRC and numerous virulence factors. Tissue microbiome profiles revealed early microbial colonization of tumors, with CRC-associated microbes more abundant in adjacent non-tumor tissue than in fecal samples. This suggests a dilution effect in fecal readouts, hindering the detection of early-stage and right-sided tumors. While a unified microbiome-based classifier achieved an Area Under the Curve (AUC) of approximately 0.84 for CRC detection, this is lower than established non-invasive diagnostic tests, and reliable detection of adenomas remains challenging (AUC ~0.65). However, a negative association was found between the CRC microbiome score and dietary fiber intake, with dietary interventions, including fiber supplementation, significantly reducing the CRC microbiome signature score. Functional analysis showed CRC-enriched carbohydrate-active enzymes (CAZymes) targeting host-derived substrates, while depleted CAZymes targeted dietary fiber. These findings confirm a universal CRC microbiome signature and highlight its potential in preventative strategies through dietary modulation, despite current diagnostic limitations.https://cassyni-user-files-prod.s3.amazonaws.com/mxFuzavS2Z6MeXN2m3rfp https://cassyni.com/events/FGWJjGqwLc1eZEqnubzWFw/seminar/qa https://cassyni.com/slides/outline/FGWJjGqwLc1eZEqnubzWFw https://cassyni.com/events/FGWJjGqwLc1eZEqnubzWFw/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Ft7fLiCa4QCVKJUPdW6agE https://cassyni.com/events/FGWJjGqwLc1eZEqnubzWFw?videoPreview=1 Clinical case discussionsnohttps://cassyni.com/events/FGWJjGqwLc1eZEqnubzWFw?videoPreview=12025-10-14T09:00:00+00:002697.24North West London Kidney CareThis seminar presents clinical case discussions focusing on chronic kidney disease (CKD) management across diverse patient profiles. Four cases illustrate common diagnostic and therapeutic challenges in CKD staging, monitoring, and treatment decisions. The first case involves a 45-year-old man with hypertension and mildly elevated albuminuria (G2A3), highlighting the limitations of estimated glomerular filtration rate (eGFR) accuracy in normal ranges and emphasizing primary care follow-up with annual monitoring and lifestyle modification. The second case describes a 37-year-old woman with microscopic hematuria and mild proteinuria (G1A2), raising differential diagnoses including glomerulonephritis and genetic kidney disease, warranting secondary care referral and possible biopsy. The third case features a 57-year-old man with type 2 diabetes, declining eGFR (G3A), persistent albuminuria despite optimized renin-angiotensin-aldosterone system inhibition and SGLT2 inhibitor therapy, suggesting consideration of finerenone initiation under nephrology supervision alongside lifestyle interventions. The final cases compare two 82-year-old women with identical renal function and albuminuria but differing comorbidities and functional status, underscoring individualized management and the low likelihood of dialysis requirement in elderly patients with stable CKD. Throughout, the discussions emphasize the importance of integrating clinical context, risk stratification tools such as the Kidney Failure Risk Equation, and guideline-based pharmacologic and non-pharmacologic strategies to optimize outcomes. The seminar reinforces the role of primary care in CKD monitoring, the judicious use of specialist referral, and the prioritization of lifestyle modification alongside pharmacotherapy.https://cassyni-user-files-prod.s3.amazonaws.com/Ft7fLiCa4QCVKJUPdW6agE https://cassyni.com/events/PAwDhUE7Aej324e1uzWyhw/seminar/qa https://cassyni.com/slides/outline/PAwDhUE7Aej324e1uzWyhw https://cassyni.com/events/PAwDhUE7Aej324e1uzWyhw/abstract https://cassyni-user-files-prod.s3.amazonaws.com/MRrg67VaascaxL43Mi22Kp https://cassyni.com/events/PAwDhUE7Aej324e1uzWyhw?videoPreview=1 Digital Twins and their Impact Across Science, Technology and Societynohttps://cassyni.com/events/PAwDhUE7Aej324e1uzWyhw?videoPreview=12025-11-06T14:00:00+00:004450.48ArtIStE - Artificial Intelligence in Structural EngineeringThis talk presents digital twins as powerful computational representations of physical systems that evolve over time and interact bidirectionally with their real-world counterparts. It will explore the mathematical and algorithmic foundations behind digital twins, including reduced-order models and scientific machine learning methods. Applications across aerospace, civil infrastructure, and personalized medicine will illustrate their broad societal impact and transformative potential. https://cassyni-user-files-prod.s3.amazonaws.com/MRrg67VaascaxL43Mi22Kp https://cassyni.com/events/W61gM3HTK4UpWsdbHS5urd/seminar/qa https://cassyni.com/slides/outline/W61gM3HTK4UpWsdbHS5urd https://cassyni.com/events/W61gM3HTK4UpWsdbHS5urd/abstract https://cassyni-user-files-prod.s3.amazonaws.com/RQX9vsciG7NsZrCDpzux6r https://cassyni.com/events/W61gM3HTK4UpWsdbHS5urd?videoPreview=1 Magnetized implosions on the National Ignition Facilitynohttps://cassyni.com/events/W61gM3HTK4UpWsdbHS5urd?videoPreview=12025-09-25T15:00:00+00:004030.0Journal of Plasma PhysicsExperiments on the NIF have demonstrated the use of pre-imposed magnetic fields to enhance ICF performance, with a 3x yield enhancement observed using an initial 26T field. This performance increase is roughly in line with predictions assuming suppression of thermal conduction in 2 of the 3 dimensions; this theoretical scaling will be outlined in this talk. Further enhancements are expected from the application of non-uniform magnetic fields, with mirror fields containing heat within the hot-spot more effectively than axial fields. While magnetic fields are predicted to improve high-yield cryogenic implosions, their impact has only been assessed for experiments designed under the assumption of no imposed magnetic field. This talk presents the first work to redesign a spherical ICF implosion to best utilize the benefits of applying an external field. The sub-ignition experiment N170601 is taken as the baseline design, which used 1.57MJ of laser energy. Here only the ablator and ice thickness are varied. It is found that the magnetized design benefits from increasing the shell thickness by 14μm and decreasing the ice thickness by 18μm, resulting in a neutron yield of8.9×10^17. This is 34 times greater than the unmagnetized simulation of the same design, and 18.5 times the greatest unmagnetized simulation across all designs simulated. This design was found by using a simplified 1D magnetization model, then validated against full 2D extended-MHD capsule simulations with radiation asymmetries applied to correct the shape. Tension in the magnetic field lines can also result in suppression of the Rayleigh-Taylor instability. The consequences of this for mix of high-Z material into ICF hot-spots will be discussed.https://cassyni-user-files-prod.s3.amazonaws.com/RQX9vsciG7NsZrCDpzux6r https://cassyni.com/slides/outline/TVv7wraZaVLMpi5jj8hU9 https://cassyni.com/events/TVv7wraZaVLMpi5jj8hU9/abstract https://cassyni-user-files-prod.s3.amazonaws.com/B37a8kdmZuHJ6SoJWFEHci https://cassyni.com/events/TVv7wraZaVLMpi5jj8hU9?videoPreview=1 Transcriptomics-Based TCM Network Pharmacology: Theory, Methodology And Applicationsnohttps://cassyni.com/events/TVv7wraZaVLMpi5jj8hU9?videoPreview=12025-05-14T06:00:00+00:005366.56The Pharmacological Research family of journalsTraditional Chinese medicines (TCM), in “multi-component, multi-target, multi-pathway” paradigm, show satisfactory clinical results in complex diseases. Network pharmacology provides a novel paradigm to uncover and visualize the underlying interaction networks of TCMs against multifactorial diseases. The development and application of Network pharmacology has promoted the safety, efficacy, and mechanism investigations of TCMs, which then reinforces the credibility and popularity of TCMs. In the past decades, with the advent of advanced and intelligent technologies (such as metabolomics, proteomics, transcriptomics, single-cell omics, and artificial intelligence), Network pharmacology has been improved and deeply implemented and presented its great value and potential as the next drug-discovery paradigm. This talk briefly summarizes the recent research progress on Transcriptomics-based Network pharmacology application in TCMs for efficacy research, mechanism elucidation, target prediction, safety evaluation, drug repurposing, and drug design.https://cassyni-user-files-prod.s3.amazonaws.com/B37a8kdmZuHJ6SoJWFEHci https://cassyni.com/slides/outline/EmrhgbCQu9TbZUJuKAhhzd https://cassyni.com/events/EmrhgbCQu9TbZUJuKAhhzd/abstract https://cassyni-user-files-prod.s3.amazonaws.com/LRrUshkHzedKpdXbEb3ZPL https://cassyni.com/events/EmrhgbCQu9TbZUJuKAhhzd?videoPreview=1 Equity for Women in Science at the University of Massachusetts Amherstnohttps://cassyni.com/events/EmrhgbCQu9TbZUJuKAhhzd?videoPreview=12024-03-05T09:00:00+00:001480.6 School of Public PolicyNo abstracthttps://cassyni-user-files-prod.s3.amazonaws.com/LRrUshkHzedKpdXbEb3ZPL https://cassyni.com/slides/outline/HF8M2dwvVoA8oRpRZ8ntK7 https://cassyni.com/events/HF8M2dwvVoA8oRpRZ8ntK7/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Nj2eyHoGrHDJDsAhivX1C2 https://cassyni.com/events/HF8M2dwvVoA8oRpRZ8ntK7?videoPreview=1 Remembrance and Reconciliationnohttps://cassyni.com/events/HF8M2dwvVoA8oRpRZ8ntK7?videoPreview=12017-02-24T09:00:00+00:005346.12 School of Public PolicyThe seminar on “Remembrance and Reconciliation” centered on the 1906 Atlanta Race Riot, a historically underacknowledged episode of racial violence with enduring social and political ramifications. The discussion contextualized the riot within Atlanta’s racial climate, highlighting persistent segregation, disenfranchisement, and systemic racism that continued well into the mid-20th century. The analysis emphasized how sensationalized and fabricated accusations against Black men fueled the violence, which resulted in numerous deaths and widespread destruction, yet was quickly minimized by city officials and business elites concerned primarily with protecting Atlanta’s image. Panelists traced the riot’s legacy through patterns of spatial segregation, political disenfranchisement, and class divisions within the Black community, noting that meaningful change in race relations only began with increased Black political participation post-1946. Personal narratives underscored the intergenerational trauma and the complex dynamics of race, class, and privilege in Atlanta’s history. The seminar also addressed the challenges of educating new generations about this history, advocating for its inclusion in school curricula and community dialogue as essential steps toward healing and collective understanding. The event concluded with reflections on the importance of sustained public engagement, historical acknowledgment, and the potential for reconciliation through informed discourse, emphasizing that confronting this painful past is vital for fostering a more inclusive and equitable future.https://cassyni-user-files-prod.s3.amazonaws.com/Nj2eyHoGrHDJDsAhivX1C2 https://cassyni.com/slides/outline/Tcmf7d3q7miHUiPopeHYrR https://cassyni.com/events/Tcmf7d3q7miHUiPopeHYrR/abstract https://cassyni-user-files-prod.s3.amazonaws.com/6eDjb19FXFusrzc1sCMbZ8 https://cassyni.com/events/Tcmf7d3q7miHUiPopeHYrR?videoPreview=1 Rethinking cities in the face of extreme heatnohttps://cassyni.com/events/Tcmf7d3q7miHUiPopeHYrR?videoPreview=12022-10-26T06:00:00+00:003680.32Part of the nonprofit Annual Reviews organizationCities have recently experienced extreme heat waves, causing preventable illness and death. How can we protect people from dangerous heat while also reducing carbon emissions? https://cassyni-user-files-prod.s3.amazonaws.com/6eDjb19FXFusrzc1sCMbZ8 https://cassyni.com/events/CoKXj7e5x36fAn76ozTpJh/seminar/qa https://cassyni.com/slides/outline/CoKXj7e5x36fAn76ozTpJh https://cassyni.com/events/CoKXj7e5x36fAn76ozTpJh/abstract https://cassyni-user-files-prod.s3.amazonaws.com/59dCf8wdEii9g3bkyvEYd4 https://cassyni.com/events/CoKXj7e5x36fAn76ozTpJh?videoPreview=1 3D printing nanoporous separation materials – towards scalable and sustainable membrane productionnohttps://cassyni.com/events/CoKXj7e5x36fAn76ozTpJh?videoPreview=12025-12-16T11:00:00+00:003422.0ElsevierOver the past 20 years, 3D printing technologies have emerged as innovative tools to generate macro-porous materials, with potential in complex structures impossible to otherwise develop by traditional manufacturing. More recently, advanced composite materials have been developed at the mili and micro scale following progress in new polymers and resins formulations as well as greater resolution control for both Fused Deposition Modelling (FDM) and Dynamic Light Polymerisation (DLP). Breaching the micron-scale barrier, to generate nano-porous materials has however remained to date a major challenge, due to either rheological limitations or minimum printable pixel size achievable. New strategies arising from polymer monoliths development have however emerged to generate ultra-porous materials, with macron-sized thicknesses and yet nanoscale pores. Our team has developed innovative strategies based on advanced resins formulations to print nano-porous membranes, and nano-textured catalysts as well as adsorbents. In this presentation, the feasibility to develop complex 3D membrane architectures with the novel process will be demonstrated for a range of chemistries and materials. Nanocomposite structures with excellent nano-load distributions and incorporation into porous polymeric matrixes will also be demonstrated.https://cassyni-user-files-prod.s3.amazonaws.com/59dCf8wdEii9g3bkyvEYd4 https://cassyni.com/events/3ugH1SWXTA4D8VdUgy7DcH/seminar/qa https://cassyni.com/slides/outline/3ugH1SWXTA4D8VdUgy7DcH https://cassyni.com/events/3ugH1SWXTA4D8VdUgy7DcH/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Cgq9GSakKrRy53gH2VdLBp https://cassyni.com/events/3ugH1SWXTA4D8VdUgy7DcH?videoPreview=1 Perspectives on viscoplastic fluid flownohttps://cassyni.com/events/3ugH1SWXTA4D8VdUgy7DcH?videoPreview=12025-12-04T16:00:00+00:003991.04Journal of Fluid MechanicsThere is a long history of understanding low-Reynolds-number hydrodynamics, with numerous elegant techniques to dissect and interpret Stokes flows. One cannot say the same for yield-stress fluids. For these materials, the nonlinearity associated with the yield stress complicates analysis and prevents the use of many of the techniques used for slow viscous flow. Simultaneously, the presence of a yield stress introduces a range of new features into the problem beyond those of traditional Stokes flow. Here we discuss the impact of a yield stress in the relatively simple setting of two-dimensional, steady, inertialess flow, and using a few different canonical flow problems to illustrate results (e.g. flow through a constriction; translation and rotation of a cylinder; gravitational failure modes and collapse). The main goals are to establish intuition for the dramatically different features that can be introduced to the flow by the yield stress, and to outline the various tools available to the modeller to construct and interpret these flows. https://cassyni-user-files-prod.s3.amazonaws.com/Cgq9GSakKrRy53gH2VdLBp https://cassyni.com/events/LhkShK2Fn5p3dJKUrYNxXX/seminar/qa https://cassyni.com/slides/outline/LhkShK2Fn5p3dJKUrYNxXX https://cassyni.com/events/LhkShK2Fn5p3dJKUrYNxXX/abstract https://cassyni-user-files-prod.s3.amazonaws.com/MAbanELUUmm22J14CoZT7U https://cassyni.com/events/LhkShK2Fn5p3dJKUrYNxXX?videoPreview=1 Rewiring of cortical glucose metabolism fuels human brain cancer growthnohttps://cassyni.com/events/LhkShK2Fn5p3dJKUrYNxXX?videoPreview=12026-06-18T18:00:00+00:003629.52Center for Cancer TrainingThe brain avidly consumes glucose to fuel neurophysiology. Cancers of the brain, such as glioblastoma, relinquish physiological integrity and gain the ability to proliferate and invade healthy tissue. How brain cancers rewire glucose utilization to drive aggressive growth remains unclear. We infused 13C-labeled glucose into patients and mice with brain cancer, coupled with quantitative metabolic flux analysis, to map the fates of glucose-derived carbon in tumor versus cortex. Through direct and comprehensive measurements of carbon and nitrogen labeling in both cortex and glioma tissues, we identify profound metabolic transformations. In the human cortex, glucose carbons fuel essential physiological processes, including TCA cycle oxidation and neurotransmitter synthesis. Conversely, gliomas downregulate these processes and scavenge alternative carbon sources such as amino acids from the environment, repurposing glucose-derived carbons to generate molecules needed for proliferation and invasion. Targeting this metabolic rewiring in mice through dietary amino acid modulation selectively alters glioblastoma metabolism, slows tumor growth, and augments the efficacy of standard-of-care treatments. These findings illuminate how aggressive brain tumors exploit glucose to suppress normal physiological activity in favor of malignant expansion and offer potential therapeutic strategies to enhance treatment outcomes.https://cassyni-user-files-prod.s3.amazonaws.com/MAbanELUUmm22J14CoZT7U https://cassyni.com/events/V6miUw2BEsE2ndfwvPi1kR/seminar/qa https://cassyni.com/slides/outline/V6miUw2BEsE2ndfwvPi1kR https://cassyni.com/events/V6miUw2BEsE2ndfwvPi1kR/abstract https://cassyni-user-files-prod.s3.amazonaws.com/KFsRrV4JYrf1kYom2w52NS https://cassyni.com/events/V6miUw2BEsE2ndfwvPi1kR?videoPreview=1 Advanced Metamaterials: Virtual Journal Launch Ceremony - Option 1 Europe and Asia nohttps://cassyni.com/events/V6miUw2BEsE2ndfwvPi1kR?videoPreview=12026-03-11T12:00:00+00:004034.72Springer Nature Physics CommunityIn this special webinar, we will introduce the newly-launched open access journal Advanced Metamaterials, published by Springer Nature. Editor in Chief Prof. Chris Geddes, along with Josh Bayliss (Senior Publisher) and Christian Kohl (Commissioning Editor) will present: – An introduction to Prof. Chris D. Geddes, the Editor-in-Chief of Advanced Metamaterials – An overview of the journal – Aims & scope and the types of papers we’re looking to publish – A look at the currently open collections – Time for questions – Professor Geddes will then deliver an online seminar (25 mins plus 15 mins for questions) on one aspect of his research, "Fluorophore-Induced Plasmonic Current from Plasmonically Active Metasurfaces" We welcome you to come with your questions about the journal, the field, and any potential submissions. We are holding a second webinar, with timing more suitable for the Americas. Please see here: https://cassyni.com/events/VbRKXcfhgKn8Tcy4RvtYJ1?f2i649 https://cassyni-user-files-prod.s3.amazonaws.com/KFsRrV4JYrf1kYom2w52NS https://cassyni.com/slides/outline/KiNNG4BYh5vdANHz6phX33 https://cassyni.com/events/KiNNG4BYh5vdANHz6phX33/abstract https://cassyni-user-files-prod.s3.amazonaws.com/T7g4nQqLMx8N86NnqdjPcA https://cassyni.com/events/KiNNG4BYh5vdANHz6phX33?videoPreview=1 Trust and the Ethics of AInohttps://cassyni.com/events/KiNNG4BYh5vdANHz6phX33?videoPreview=12022-06-20T08:00:00+00:0012165.96 School of Public PolicyThis workshop aims to address some of the insights that we have gained about the ethics of AI and the concept of trust. We critically explore practical and theoretical issues relating to values and frameworks, engaging with carebots, evaluations of decision support systems, and norms in the private sector. We assess the objects of trust in a democratic setting and discuss how scholars can further shift insights from academia to other sectors.https://cassyni-user-files-prod.s3.amazonaws.com/T7g4nQqLMx8N86NnqdjPcA https://cassyni.com/events/Xa1jiMFoS9zX9a9WU5ceUM/seminar/qa https://cassyni.com/slides/outline/Xa1jiMFoS9zX9a9WU5ceUM https://cassyni.com/events/Xa1jiMFoS9zX9a9WU5ceUM/abstract https://cassyni-user-files-prod.s3.amazonaws.com/4LdemvNfZT9TrNuai7G2Dk https://cassyni.com/events/Xa1jiMFoS9zX9a9WU5ceUM?videoPreview=1 Meta-biomaterialsnohttps://cassyni.com/events/Xa1jiMFoS9zX9a9WU5ceUM?videoPreview=12026-02-10T14:00:00+00:002806.04MetaMATThis talk examines meta-biomaterials, which are engineered materials that achieve extraordinary physical and biological capabilities through their specific internal structures and surface treatments. By precisely controlling the geometry and topology of these materials at the microscopic level, scientists can dictate how they behave at a larger scale. The work explores several dimensions of this design process across multiple size regimes. At the macroscale, the focus remains on creating personalized medical implants and adaptable devices such as metallic clay. Moving to the microscale, the study investigates how multi-material additive manufacturing and auxetic structures influence cellular behavior through specific curvatures. Furthermore, nanoscale analysis examines how surface textures can enhance bone growth, modulate immune responses, and eliminate harmful bacteria. To unify these various scales into a single functional unit, the research employs origami and kirigami techniques, along with 4D printing, to develop self-folding, shape-shifting materials that can even incorporate flexible electronic components for advanced biomedical monitoring or therapy.https://cassyni-user-files-prod.s3.amazonaws.com/4LdemvNfZT9TrNuai7G2Dk https://cassyni.com/slides/outline/U7UWPZj8Mx7t7sqwpREgwX https://cassyni.com/events/U7UWPZj8Mx7t7sqwpREgwX/abstract https://cassyni-user-files-prod.s3.amazonaws.com/7GH2ui2E36eQwBCB7zZS4W https://cassyni.com/events/U7UWPZj8Mx7t7sqwpREgwX?videoPreview=1 Design and Safety Monitoring of Combination Therapies in Phase I Clinical Trialsnohttps://cassyni.com/events/U7UWPZj8Mx7t7sqwpREgwX?videoPreview=12026-03-20T14:00:00+00:002242.72Journal of Statistical Theory and PracticePhase I clinical trials represent the first step in evaluating new drugs in humans and have become increasingly complex with the growing use of combination therapies. The primary objective of Phase I trials is to identify a recommended dose that is safe, efficient, and reliable for use in subsequent phases of drug development. Although Phase I trials were historically viewed as having limited therapeutic benefit, methodological advances over the past decade have improved their ethical and clinical relevance, allowing them to serve as viable treatment options for patients. In this review, we examine major Phase I trial designs, including rule-based, model-based, and model-assisted approaches. We also discuss Phase I dose-expansion trials, which are often conducted on an ad hoc basis, and provide a theoretical justification for their use. Furthermore, we propose systematic rules for safety and toxicity monitoring in combination therapy trials, accounting for varying toxicity rates and type I error control. These considerations aim to improve the design, conduct, and interpretability of Phase I combination therapy trials.https://cassyni-user-files-prod.s3.amazonaws.com/7GH2ui2E36eQwBCB7zZS4W https://cassyni.com/slides/outline/Y4aUR9MffXmV43Xo5BGFBB https://cassyni.com/events/Y4aUR9MffXmV43Xo5BGFBB/abstract https://cassyni-user-files-prod.s3.amazonaws.com/AduDN88H96dwjTWQR7ftgE https://cassyni.com/events/Y4aUR9MffXmV43Xo5BGFBB?videoPreview=1 Turbulence over rough, textured and complex surfacesnohttps://cassyni.com/events/Y4aUR9MffXmV43Xo5BGFBB?videoPreview=12025-12-10T12:00:00+00:003334.04Department of AeronauticsThis talk will present an overview of our group's current understanding of the interaction of non-smooth surfaces in general with wall-bounded turbulence, drawing from examples on riblets, superhydrophobic surfaces, canopies, porous and rough surfaces. In most cases, the flow exhibits outer-layer similarity, such that sufficiently far above the surface the only effect is a shift in the mean velocity profile. This has been challenged in the last couple of decades for some surfaces, but mostly as a result of artifacts in data processing. Provided outer-layer similarity holds, the effect of the surface is confined to the near-wall region, results in the aforementioned velocity shift, and occurs essentially through two physical mechanisms. In the first, surface texture imposes a set of effective boundary conditions on the overlying, texture-incoherent background turbulence, that can take the form of velocity-stress admittance. The effect of inertia and the lack of separation of scales between the texture and the turbulent eddies need to be retained to compute the admittance coefficients accurately. When the resulting effective transpiration is small, slip dominates, turbulence remains smooth-wall-like and the effective boundary conditions give rise to Paolo Luchini's `protrusion-height' regime. When the transpiration effect is large, it can by itself account for the changes in the overlying turbulence - this is the case for high-permeability porous substrates. The second mechanism is the non-linear interaction of the texture-coherent flow with the overlying, texture-incoherent turbulence, which acts on the latter as a forcing term, altering the momentum equations. Including this forcing term in otherwise-texture-less simulations is sufficient to capture the effect of the texture granularity on the overlying turbulence.https://cassyni-user-files-prod.s3.amazonaws.com/AduDN88H96dwjTWQR7ftgE https://cassyni.com/slides/outline/SdSpudEtqVgQfBHZUGGTBj https://cassyni.com/events/SdSpudEtqVgQfBHZUGGTBj/abstract https://cassyni-user-files-prod.s3.amazonaws.com/DDX6QbbJBbBCbddmFS6ZY2 https://cassyni.com/events/SdSpudEtqVgQfBHZUGGTBj?videoPreview=1 Data-Informed Modeling to Accelerate the Improvement of Sustainable Technohttps://cassyni.com/events/SdSpudEtqVgQfBHZUGGTBj?videoPreview=12024-03-14T09:00:00+00:003845.4 School of Public PolicyThis seminar presents a data-informed framework to accelerate the improvement of sustainable technologies, focusing on energy storage as a critical enabler for integrating intermittent renewable resources into reliable electricity grids. The approach involves a five-step cycle: defining technology performance requirements in context, identifying key technology features, investigating strategies to improve and deploy these features, informing decision-makers, and iteratively reassessing goals as technologies and conditions evolve. Using a parsimonious energy system model with two decades of hourly solar and wind data across diverse U.S. regions, the analysis reveals that the levelized cost of renewable electricity shaped by storage is more sensitive to the cost of storage energy capacity than power capacity. Cost-competitive renewable electricity with full reliability requires storage energy capacity costs below approximately \$20/kWh, whereas allowing a 5% reliance on other technologies raises this target to \$150/kWh. Complementing this system-level insight, an empirical and mechanistic study of lithium-ion batteries—key for transportation and stationary storage—shows a 97% cost decline from 1991 to 2018, driven primarily by increases in cell charge density, reductions in material costs, and manufacturing scale. Public and private research and development accounted for 54% of cost reductions, outweighing economies of scale and learning-by-doing effects. The findings underscore the importance of sustained R&D investment post-commercialization and encourage exploration of diverse chemistries within modular designs to enable rapid technological progress. These integrated insights inform targeted research, policy, and investment strategies essential for advancing energy storage technologies critical to climate mitigation goals.https://cassyni-user-files-prod.s3.amazonaws.com/DDX6QbbJBbBCbddmFS6ZY2 https://cassyni.com/slides/outline/5tDSxv4rQGR9XBqHC9M7JD https://cassyni.com/events/5tDSxv4rQGR9XBqHC9M7JD/abstract https://cassyni-user-files-prod.s3.amazonaws.com/NXH8xsP3gkA6q12EnZg4nA https://cassyni.com/events/5tDSxv4rQGR9XBqHC9M7JD?videoPreview=1 COVID-19 Research Lightning Talk: Search Technology Inc & Georgia Institute Technologynohttps://cassyni.com/events/5tDSxv4rQGR9XBqHC9M7JD?videoPreview=12022-01-13T09:00:00+00:00531.2 School of Public PolicyThis study addresses the challenge of extracting actionable knowledge from the rapidly expanding COVID-19 biomedical literature to improve access and support research on causes and cures. Utilizing a dataset of approximately 60,000 records from the National Library of Medicine’s core COVID search strategy through October 2020, the analysis applies intelligent bibliometrics to identify topical clusters and track their evolution over time via term co-occurrence and clustering techniques. Notable findings include the identification of rapidly spreading topics such as treatment of infectious diseases and links to prior coronavirus research. A literature-based discovery approach is implemented through a recommender system that leverages term frequency-inverse document frequency (TF-IDF) calculations to identify relevant articles both within and beyond the COVID literature, exemplified by a focus on comorbidities and citation counts to prioritize influential works. Additionally, a dynamic dashboard aggregates over 153,000 abstracts as of January 2022, enabling interactive exploration by topic, geography, and author affiliation, thus facilitating timely insight into emerging research trends. This integrated framework demonstrates the potential of tech mining and recommender systems to enhance literature accessibility and discovery in fast-moving biomedical domains, supporting informed decision-making and hypothesis generation. Ongoing development of the dashboard aims to refine categorization and usability, suggesting future applications in broader scientific and technological fields.https://cassyni-user-files-prod.s3.amazonaws.com/NXH8xsP3gkA6q12EnZg4nA https://cassyni.com/slides/outline/DHwWfAmiz8iz1mMkA2CqiD https://cassyni.com/events/DHwWfAmiz8iz1mMkA2CqiD/abstract https://cassyni-user-files-prod.s3.amazonaws.com/QohHqojZLzNocV5SQmtvSi https://cassyni.com/events/DHwWfAmiz8iz1mMkA2CqiD?videoPreview=1 Formulation of a self-consistent reduced transport theory for discrete modes-with applications to resonant dynamics in plasmas and galaxiesnohttps://cassyni.com/events/DHwWfAmiz8iz1mMkA2CqiD?videoPreview=12024-02-15T06:00:00+00:002877.72Journal of Plasma PhysicsResonances, though delicate fine structures in phase space, can mediate massive transport of particles in plasmas. In this colloquium, it will be shown that a quasilinear plasma transport theory that incorporates Fokker-Planck dynamical friction (drag) and pitch angle scattering self-consistently emerges from first principles for an isolated, marginally unstable mode resonating with an energetic minority species. It is found that drag fundamentally changes the structure of the wave-particle resonance, breaking its symmetry and leading to the shifting and splitting of resonance lines. In contrast, scattering broadens the resonance in a symmetric fashion. Comparison with fully nonlinear simulations shows that the emergent quasilinear system preserves the exact instability saturation amplitude and the corresponding particle redistribution of the fully nonlinear theory. Even in situations in which drag leads to a relatively small resonance shift, it still underpins major changes in the redistribution of resonant particles. This novel influence of drag is equally important in plasmas and self-gravitating systems. In fusion plasmas, the effects are especially pronounced for fast-ion-driven instabilities in tokamaks with low aspect ratio or negative triangularity, as evidenced by past observations. The same theory directly maps to the resonant dynamics of the rotating galactic bar and massive bodies in its orbit, providing new techniques for analyzing galactic dynamics.https://cassyni-user-files-prod.s3.amazonaws.com/QohHqojZLzNocV5SQmtvSi https://cassyni.com/events/FmBXtb1MBRVUNhqJhi7US9/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Gjn1afEkuJLSbrsbx7toug https://cassyni.com/slides/outline/CJeJZoUg7DcqM1Xk43jWuK https://cassyni.com/events/CJeJZoUg7DcqM1Xk43jWuK/abstract https://cassyni-user-files-prod.s3.amazonaws.com/BouDASD6rXUvEqYCXTrEGW https://cassyni.com/events/CJeJZoUg7DcqM1Xk43jWuK?videoPreview=1 Beyond the Buzzwords: What Digital Transformation Really Looks Like from the Frontlinenohttps://cassyni.com/events/CJeJZoUg7DcqM1Xk43jWuK?videoPreview=12025-08-21T08:00:00+00:003041.28Business SchoolDigital transformation initiatives are critical yet inherently complex undertakings that require careful orchestration of people, processes, and systems to achieve sustainable business value. This analysis synthesizes practical insights from extensive leadership experience across diverse sectors—including energy retail, banking, and consumer appliances—to elucidate the realities of digital transformation beyond common rhetoric. Key success factors identified include establishing a clear, business-driven vision aligned with organizational strategy, securing strong and engaged executive leadership, and assembling experienced teams capable of navigating technical and organizational challenges. Emphasis is placed on maintaining a focused scope to manage complexity, fostering a culture and mindset open to change, and ensuring continuous business engagement throughout the transformation lifecycle. Examples illustrate how integrated digital capabilities—such as combined billing and CRM platforms in energy retail, mobile banking innovations responding to shifting customer behaviors, and direct-to-consumer e-commerce models in appliances—serve as foundational enablers for growth and operational agility. The findings highlight that transformation is not a finite project but an ongoing journey where initial delivery marks a starting point for realizing value. Rigorous planning, risk management, and measurement practices underpin progress, while pragmatic decision-making and ownership at all levels sustain momentum. Ultimately, the analysis underscores that successful digital transformation hinges on people’s engagement and adaptability, with leadership playing a pivotal role in steering organizations through the inherent difficulties toward meaningful and lasting change.https://cassyni-user-files-prod.s3.amazonaws.com/BouDASD6rXUvEqYCXTrEGW https://cassyni.com/slides/outline/HjoaBx7LLcdxdCPnK5XBiV https://cassyni.com/events/HjoaBx7LLcdxdCPnK5XBiV/abstract https://cassyni-user-files-prod.s3.amazonaws.com/MQ4PQYnNE57s7AU8fLZmre https://cassyni.com/events/HjoaBx7LLcdxdCPnK5XBiV?videoPreview=1 Data-driven Lagrangian reduced-order models and control of soft swimming robotsnohttps://cassyni.com/events/HjoaBx7LLcdxdCPnK5XBiV?videoPreview=12025-11-07T20:00:00+00:003478.6AI Institute in Dynamic SystemsSoft swimming robots provide a quieter and safer solution to underwater exploration than other forms of autonomous underwater vehicles, which are often propeller-driven. Anguilliform swimming is an effective mode of locomotion utilized by elongated fish like eels and oarfish to travel long distances. It is characterized by the use of full-body undulations that produce thrust and it proves highly energy efficient. Mimicking these swimming forms through actuation, sensing, and control is challenging. In this talk, we present efforts towards learning the low-dimensional dynamics from high-dimensional data, and designing closed-loop model predictive controllers to track natural swimming modes. In that direction, we first describe a method to leverage the Lagrangian model description of the anguilliform swimmer to learn structure-preserving reduced-order models via Lagrangian Operator Inference. Specifically, the data comes from simulations of an approximately 250,000 degrees-of-freedom nonlinear finite element model which is excited by a frequency-sweep of inputs that produce typical swimming modes. We then use these second-order structured Lagrangian models for model predictive control of the centerline trajectory of the soft robot. We compare the controllers’ performance with other controllers derived from prominent linear data-driven model reduction techniques.https://cassyni-user-files-prod.s3.amazonaws.com/MQ4PQYnNE57s7AU8fLZmre https://cassyni.com/slides/outline/YZFhaTX5WMFJsp79q7zYaZ https://cassyni.com/events/YZFhaTX5WMFJsp79q7zYaZ/abstract https://cassyni-user-files-prod.s3.amazonaws.com/7v773qMCVSNuAjXbmDT3CA https://cassyni.com/events/YZFhaTX5WMFJsp79q7zYaZ?videoPreview=1 Towards Translating Bioengineering Research: Challenges and Rewardsnohttps://cassyni.com/events/YZFhaTX5WMFJsp79q7zYaZ?videoPreview=12025-10-21T03:00:00+00:003931.72The Auckland Bioengineering InstituteAn interdisciplinary journey engaged in theoretical, numerical, computational, physiological, imaging, and medical research has defined a bioengineering career-to-date packed with fun, frustration, fantastic people, hard work and intellectual satisfaction. While it is rewarding, that's not enough! The real challenge is to stir up that melting pot and extract and apply some really cool ideas, techniques, tools that can help to increase understanding and ultimately have a positive impact. This presentation will illustrate that journey, and some career learnings along the way, with a view to translating bioengineering research towards improving patient care.https://cassyni-user-files-prod.s3.amazonaws.com/7v773qMCVSNuAjXbmDT3CA https://cassyni.com/slides/outline/8MV6JxpMzv7Qi8MJuLhFAD https://cassyni.com/events/8MV6JxpMzv7Qi8MJuLhFAD/abstract https://cassyni-user-files-prod.s3.amazonaws.com/hjh8Ag18gNrTttfriebpz https://cassyni.com/events/8MV6JxpMzv7Qi8MJuLhFAD?videoPreview=1 The Science of Sourdoughnohttps://cassyni.com/events/8MV6JxpMzv7Qi8MJuLhFAD?videoPreview=12020-10-15T06:00:00+00:003653.08Part of the nonprofit Annual Reviews organizationAs the Covid-19 pandemic forced people in lockdown, many retreated to their kitchens. Photos of frothy sourdough starters and freshly baked bread — the fruits of at-home experiments with just water, flour and a spoon — flooded social media. These nourishing endeavors were fueled by living microbes in the sourdough starter, which originated in the flour, the air and even the baker’s hands. Researchers, sometimes with help from home bakers, are still uncovering how various species of yeast and bacteria — and the conditions in which they thrive — contribute to each unique loaf.https://cassyni-user-files-prod.s3.amazonaws.com/hjh8Ag18gNrTttfriebpz https://cassyni.com/slides/outline/2vMSoShbAt2LKG75JRhTAm https://cassyni.com/events/2vMSoShbAt2LKG75JRhTAm/abstract https://cassyni-user-files-prod.s3.amazonaws.com/KPLoMiLDNCQQgaZv1BH91Y https://cassyni.com/events/2vMSoShbAt2LKG75JRhTAm?videoPreview=1 Transition to and from Turbulence in a Vertical Heated Pipenohttps://cassyni.com/events/2vMSoShbAt2LKG75JRhTAm?videoPreview=12025-06-12T06:00:00+00:003232.64Leeds Institute for Fluid DynamicsThe transition from laminar to turbulent flow in a pipe remains one of the oldest outstanding problems in fluid mechanics. In a vertically-aligned pipe, under the influence of heating, the opposite process has been observed, i.e. turbulence may be partially or fully suppressed by buoyancy forces. As the suppression of turbulence leads to severe heat transfer deterioration, this phenomenon is undesirable in both heating and cooling applications, such as nuclear reactor cooling systems and geothermal energy capture. In this talk, I will present our recent advances in understanding, predicting and optimising the phenomenon of relaminarisation due to buoyancy forces through the mathematical framework of dynamical systems theory and the use of modern stability-analysis tools. Connections to turbulence control strategies in ‘ordinary’ (isothermal) pipe flow will also be discussed, where, instead, turbulence suppression is typically highly desirable, as it leads to drag reduction and lower energy consumption.https://cassyni-user-files-prod.s3.amazonaws.com/KPLoMiLDNCQQgaZv1BH91Y https://cassyni.com/events/DncjpUw8pxCoqXw6uxw97b/seminar/qa https://cassyni.com/slides/outline/DncjpUw8pxCoqXw6uxw97b https://cassyni.com/events/DncjpUw8pxCoqXw6uxw97b/abstract https://cassyni-user-files-prod.s3.amazonaws.com/PXTfnih45AocWVxNP5AS9c https://cassyni.com/events/DncjpUw8pxCoqXw6uxw97b?videoPreview=1 Modeling and Learning the Local Thermal Environment in Laser Powder Bed Fusion Additive Manufacturing nohttps://cassyni.com/events/DncjpUw8pxCoqXw6uxw97b?videoPreview=12025-12-09T15:00:00+00:003322.68Department of AeronauticsLaser Powder Bed Fusion (L-PBF) additive manufacturing enables the fabrication of geometrically intricate metallic components that are otherwise unattainable using conventional manufacturing methods. Despite this capability, uncertainties in part performance continue to hinder qualification and certification for safety-critical applications. These uncertainties stem from localized variations in the thermal environment—the dynamic interplay between heat input, accumulation, and dissipation that dictates melt pool geometry, defect formation, and microstructural evolution throughout the build. Accurately characterizing the role of local thermal environment (LTE) is therefore central to understanding process-structure–property relationships and achieving consistent part quality. To establish a physical foundation for modeling the LTE, this research first extends the classical Rosenthal model to explicitly incorporate local preheat temperature and temperature-dependent material properties, bridging the thermal conduction and convection regimes. The modified Rosenthal model provides a closed-form relationship linking the local steady-state melt pool width and depth to the preheat temperature, thereby quantifying how the local thermal environment governs melt pool size and stability. This analytical model offers a compact and interpretable framework for assessing thermal accumulation effects and serves as a benchmark for more advanced numerical and data-driven simulations. Building upon this analytical foundation, physics-based finite element (FEM) simulations are employed to resolve the evolution of the local thermal environment (LTE) across realistic part geometries. While FEM offers cost-effective part-scale prediction, traditional heat source models struggle to reproduce the fine-scale LTE variations captured by high-fidelity computational fluid dynamics (CFD). To bridge this gap, the framework integrates machine learning–enhanced heat source models within FEM. A deep-learning, dimensionality-reduction-based model enables scan-resolved simulations that update LTE fields to reflect transient heat accumulation and transfer. In parallel, a multi-network data-driven model continuously adjusts the effective heat source parameters based on evolving LTE and process conditions, achieving melt pool evolution and thermal gradients consistent with CFD. By embedding LTE as the governing variable linking analytical, numerical, and data-driven approaches, the framework unifies multi-scale thermal modeling to capture how local heat flow dictates part-scale outcomes. The resulting approach achieves high-fidelity, computationally efficient prediction of melt pool size and thermal history, enabling real-time estimation, process control, and defect mitigation. By formalizing the local thermal environment as the bridge between process parameters, material response, and part performance, this work advances a scalable foundation for predictive and intelligent manufacturing in L-PBF. https://cassyni-user-files-prod.s3.amazonaws.com/PXTfnih45AocWVxNP5AS9c https://cassyni.com/slides/outline/AL5WVhQTkkLAoqdYGJZBam https://cassyni.com/events/AL5WVhQTkkLAoqdYGJZBam/abstract https://cassyni-user-files-prod.s3.amazonaws.com/N3fgPy3z8hJkinS9ujPQna https://cassyni.com/events/AL5WVhQTkkLAoqdYGJZBam?videoPreview=1 Innovative Applications of AI in Built Structuresnohttps://cassyni.com/events/AL5WVhQTkkLAoqdYGJZBam?videoPreview=12025-09-16T07:00:00+00:002008.84ArtIStE - Artificial Intelligence in Structural EngineeringArtificial intelligence is currently being applied across a wide range of fields, from self-driving car technology to art and music generation. The built environment can be enhanced through artificial intelligence (AI), from seismic assessment to construction verification and infrastructure health monitoring. A variety of computer vision approaches have been used for these purposes, including novel combinations of established machine learning, optical character recognition and geometric methods. Using this technology and to help automate the construction verification process, machine learning models were trained to identify structural components from site photos and “read” shop drawings. These tools could be used to support construction inspection efforts and to reduce shop drawing review times from several days to a matter of hours, with an engineer reviewing a summary output from a machine learning program. Augmented reality techniques have led to creative methods of constructing structures. Examples will be shown where digital mapping of the site is overlayed with construction. Constructed projects designed by SOM with be presented.https://cassyni-user-files-prod.s3.amazonaws.com/N3fgPy3z8hJkinS9ujPQna https://cassyni.com/slides/outline/PfcSrnPX1UCrqXdXi6dwt9 https://cassyni.com/events/PfcSrnPX1UCrqXdXi6dwt9/abstract https://cassyni-user-files-prod.s3.amazonaws.com/QWWojXtgbfDt4fp1F8dNs8 https://cassyni.com/events/PfcSrnPX1UCrqXdXi6dwt9?videoPreview=1 Linking mitochondrial dynamics with mtDNA exchange- expanding the ‘social network’nohttps://cassyni.com/events/PfcSrnPX1UCrqXdXi6dwt9?videoPreview=12025-08-06T09:00:00+00:00944.0NonePlant cell mitochondria exhibit collective behaviours, with individuals moving rapidly and interacting. Mitochondrial populations are evenly spread across cellular space while forming efficient networks with high potential for exchanging contents. A framework of single-cell confocal microscopy, physical modelling and graph theory quantified behaviour and connectivity of the intracellular social network. This analysis can now include functional information on genetic contents and exchange across the population. Exogenous nucleotide staining and live imaging of Arabidopsis hypocotyl cells quantified mitochondrial subpopulations and potential mtDNA exchange events. By tracking individual organelles and their contents a detailed, quantitative, single-cell view can be taken. 3D image analysis counted individual mitochondria per cell, and those with/without mtDNA. We also introduced a genetically encoded photoconvertible fluorescent marker for mtDNA based on the bacterial H-NS binding protein.  Plant mtDNA exhibits high rates of recombination. It is hypothesised that plant mitochondria retain individual, non-reticulated shapes partly to segregate genomic material. My previous work shows that genetic perturbation leads to altered physical dynamics, and live imaging with photoconversion of mtDNA allows direct testing of physical control over the genome. Using these tools will allow us to probe the link between physical control of colocalisation, positioning and genetic dynamics- particularly in relation to plant development and mtDNA inheritance to the next generation.https://cassyni-user-files-prod.s3.amazonaws.com/QWWojXtgbfDt4fp1F8dNs8 https://cassyni.com/events/LD5DXzrqwGLDoqKy4SFzMK/abstract https://cassyni-user-files-prod.s3.amazonaws.com/8FVcdTABFwpENwX3CMFVbk https://cassyni.com/slides/outline/WaguWMSs9sxeLLd75YCt2q https://cassyni.com/events/WaguWMSs9sxeLLd75YCt2q/abstract https://cassyni-user-files-prod.s3.amazonaws.com/P9j4jsPAnzvDSrASe7XrHk https://cassyni.com/events/WaguWMSs9sxeLLd75YCt2q?videoPreview=1 Extreme Aerodynamics: Flying in Highly Gusty Conditionsnohttps://cassyni.com/events/WaguWMSs9sxeLLd75YCt2q?videoPreview=12025-10-28T14:00:00+00:003231.72Department of Aeronautics and AstronauticsAn air vehicle attempting to operate in adverse weather conditions or in the wakes of urban canyons and mountainous terrains would be affected by strong atmospheric disturbances. In such extreme aerodynamic conditions, flight control becomes a great challenge, if not impossible, due to the enormous transient forces that the vehicle experiences. Currently, encounters with these extreme flow phenomena limit the operations of fixed and rotating wing aircraft, especially those that are small to medium in size. The present study focuses on the analysis, modeling, and control of extreme aerodynamic flows, characterized by unsteadiness with amplitudes far larger than those considered in traditional aerodynamics, on a time scale comparable to that of the flow instabilities. The high dimensionality, strong nonlinearity, and multi-scale properties of these extreme flows make systematic analysis and control a tremendous challenge. Without the reduction of the state variable dimension and extraction of dominant dynamics, the application of dynamical systems and control theory for flight/flow control remains difficult. This talk will present our research group’s recent efforts to model and control such complex fluid flows by leveraging data-driven techniques. We will discuss in particular the use of unsupervised and supervised machine learning techniques and how they can be incorporated into existing flow analysis techniques. Equipped with these modern toolsets, we extract the manifolds of extreme aerodynamics to facilitate the development of sparse and reduced-order models to design flow control techniques. Some of the successes in characterizing, modeling, and controlling extreme aerodynamic flows will be presented, followed by discussions on open problems and outlooks.https://cassyni-user-files-prod.s3.amazonaws.com/P9j4jsPAnzvDSrASe7XrHk https://cassyni.com/events/8rAKUGymqjbEXbLphSpDLR/abstract https://cassyni-user-files-prod.s3.amazonaws.com/82rUF48Pa9RMCD9hWocdK4 https://cassyni.com/events/GFtPAXgeRbu52AsHfKfwkR/seminar/qa https://cassyni.com/slides/outline/GFtPAXgeRbu52AsHfKfwkR https://cassyni.com/events/GFtPAXgeRbu52AsHfKfwkR/abstract https://cassyni-user-files-prod.s3.amazonaws.com/QiiRf8QnRQ1gA6iJgXKWjx https://cassyni.com/events/GFtPAXgeRbu52AsHfKfwkR?videoPreview=1 From Kinetic Instabilities to Cosmic-Ray Transport in Galaxy Clustersnohttps://cassyni.com/events/GFtPAXgeRbu52AsHfKfwkR?videoPreview=12025-12-11T16:00:00+00:002890.04Journal of Plasma PhysicsTurbulence in high-$\beta$ plasmas drives pressure anisotropies that excite the mirror instability, producing magnetic “micromirrors” that strongly scatter cosmic rays. The intracluster medium is thereby restructured into a patchy medium with a power-law distribution of low-scattering corridors between micromirror patches. From the statistics of this medium, we construct an effective theory of cosmic-ray transport that both confines particles locally for efficient Fermi-II re-acceleration and enables rapid, Lévy-flight-like diffusion across megaparsec-scale radio halos.https://cassyni-user-files-prod.s3.amazonaws.com/QiiRf8QnRQ1gA6iJgXKWjx https://cassyni.com/slides/outline/Apkjf1ZsbZozdJd44Qg9ky https://cassyni.com/events/Apkjf1ZsbZozdJd44Qg9ky/abstract https://cassyni-user-files-prod.s3.amazonaws.com/LhisY6qEFpdCoyBRCBtNrS https://cassyni.com/events/Apkjf1ZsbZozdJd44Qg9ky?videoPreview=1 CKD: Practical learning for a Nephrology Consultantnohttps://cassyni.com/events/Apkjf1ZsbZozdJd44Qg9ky?videoPreview=12020-09-23T08:00:00+00:008632.4Imperial College Renal and Transplant CentreThis seminar addresses chronic kidney disease (CKD) with a focus on practical knowledge essential for nephrology specialty trainees transitioning to consultant roles, emphasizing clinical relevance, management, and integration with broader healthcare systems. The discussion begins with CKD definitions, epidemiology, and pathophysiology, highlighting fibrosis as the final common pathway and the importance of distinguishing public health definitions from clinical disease processes. Key drivers of CKD progression, including proteinuria, hyperfiltration, inflammation, and lipid abnormalities, are examined to inform clinical management. Measurement challenges of glomerular filtration rate (GFR) are explored, noting limitations of creatinine clearance and estimated GFR equations, and the potential role of cystatin C. Management strategies are outlined, emphasizing diagnosis, optimization of blood pressure and volume status, complication monitoring, and preparation for end-stage renal failure, supported by regional guidelines consistent with NICE recommendations. The seminar presents new therapeutic advances, particularly the use of novel potassium binders (patiromer and sodium zirconium cyclosilicate) to manage hyperkalaemia and enable optimal renin–angiotensin system inhibition, supported by clinical trial data and local audit findings. A case-based discussion on lithium nephrotoxicity elucidates its multifaceted renal effects, including nephrogenic diabetes insipidus, chronic tubulointerstitial nephritis, and hypercalcaemia via parathyroid modulation. Finally, the seminar highlights innovative care delivery models in Northwest London, including a virtual consultation service that streamlines referrals, enhances primary care collaboration, reduces outpatient burden, and prioritizes patients needing specialist input. This integrated approach aims to improve kidney health outcomes regionally while adapting nephrology practice to evolving healthcare demands.https://cassyni-user-files-prod.s3.amazonaws.com/LhisY6qEFpdCoyBRCBtNrS https://cassyni.com/events/NfymPruqJDyzQjrsDUHzGd/seminar/qa https://cassyni.com/slides/outline/NfymPruqJDyzQjrsDUHzGd https://cassyni.com/events/NfymPruqJDyzQjrsDUHzGd/abstract https://cassyni-user-files-prod.s3.amazonaws.com/WCTuUKgQ3Cdrw3CYw1krP8 https://cassyni.com/events/NfymPruqJDyzQjrsDUHzGd?videoPreview=1 Lighting the FIRE in KSTAR Plasmasnohttps://cassyni.com/events/NfymPruqJDyzQjrsDUHzGd?videoPreview=12026-04-16T15:00:00+00:002650.04Journal of Plasma PhysicsThe status of Fast Ion Regulated Enhancement (FIRE) mode experiment in KSTAR is presented. This regime is being developed for high-performance, steady-state operation, featuring a stationary ion internal transport barrier that enables central ion temperatures approaching 10 keV to be sustained for up to 50 s without delicate profile control and with no significant impurity accumulation. Its key novelty lies in the stabilization of core turbulence by fast ions. FIRE mode is achieved using neutral beam injection at moderate power near the L–H threshold while maintaining low plasma density to avoid the transition, typically in diverted configurations. Power balance and fluctuation analyses reveal a clear transport bifurcation in the ion channel. At the plasma edge, FIRE mode occasionally exhibits I-mode characteristics, including weakly coherent modes. Sawtooth oscillations are observed but tend to be stabilized during the high-performance phase, and fast ion-driven Alfvénic eigenmodes are also present, along with additional low-frequency MHD activity. Core confinement enhancement is primarily attributed to fast ion effects, evaluated in terms of dilution, alpha stabilization, and resonant interactions with turbulence, with dilution identified as the dominant mechanism. Compared with other hot ion regimes, FIRE mode is distinguished by Ti ≈ Te conditions, I-mode edge features, and long-duration sustainment. Integrated transport simulations with TRIASSIC confirm the critical role of fast ions. The future potential of FIRE mode for reactor applications is discussed, including possible extension to higher density operation.https://cassyni-user-files-prod.s3.amazonaws.com/WCTuUKgQ3Cdrw3CYw1krP8 https://cassyni.com/slides/outline/3QhCbCgNBNPPhUPhnn44G5 https://cassyni.com/events/3QhCbCgNBNPPhUPhnn44G5/abstract https://cassyni-user-files-prod.s3.amazonaws.com/NY2H5etj5EcWJPrHC9ZEuc https://cassyni.com/events/3QhCbCgNBNPPhUPhnn44G5?videoPreview=1 Intelligent Sports and Health • Series II — Brain-Computer Interface and Sports Healthnohttps://cassyni.com/events/3QhCbCgNBNPPhUPhnn44G5?videoPreview=12025-06-25T01:00:00+00:006972.04NoneTo promote academic exchanges, [Intelligent Sports and Health(ISH)](https://www.keaipublishing.com/en/journals/intelligent-sports-and-health/) hosts a series of thematic seminars. Renowned experts and active researchers are invited to share their cutting‑edge research outcomes Symposium on “Brain-Computer Interface and Sports Health” was the 2nd series for this webinar which held on Jun. 25, 2025. Four speakers shared their latest research.https://cassyni-user-files-prod.s3.amazonaws.com/NY2H5etj5EcWJPrHC9ZEuc https://cassyni.com/events/DnJtZZGPPz1pDygqoszwwb/seminar/qa https://cassyni.com/slides/outline/DnJtZZGPPz1pDygqoszwwb https://cassyni.com/events/DnJtZZGPPz1pDygqoszwwb/abstract https://cassyni-user-files-prod.s3.amazonaws.com/DMskohH9H4zB8N7whPM3Fk https://cassyni.com/events/DnJtZZGPPz1pDygqoszwwb?videoPreview=1 Advanced Concepts in Power BI Session 03nohttps://cassyni.com/events/DnJtZZGPPz1pDygqoszwwb?videoPreview=12026-04-02T14:00:00+00:003869.4Research Evaluation and Analytics Capacity Hub**3. Advanced Concepts** **Level:** Advanced **Description:** Advanced workflows and tooling for technical users, presented in a way that remains accessible to non-technical participants. - **DAX 101** - Data Analysis Expressions (DAX) is a formula expression language used in Analysis Services, Power BI, and Power Pivot in Excel - **User-Defined Functions (UDFs)** - What they are - How they change DAX development - **Using Other Languages in Power BI** - Where R and Python fit - How they can extend Power BI - **External Tools** - Extending Power BI Desktop with integrated tooling - Improving productivity and capabilityhttps://cassyni-user-files-prod.s3.amazonaws.com/DMskohH9H4zB8N7whPM3Fk https://cassyni.com/events/AKmfEmjiKn9BCHPHADczQm/seminar/qa https://cassyni.com/slides/outline/AKmfEmjiKn9BCHPHADczQm https://cassyni.com/events/AKmfEmjiKn9BCHPHADczQm/abstract https://cassyni-user-files-prod.s3.amazonaws.com/FYvE1yZc35w9Q8u79Di9yg https://cassyni.com/events/AKmfEmjiKn9BCHPHADczQm?videoPreview=1 Extinction of the human species: What could cause it and how likely is it to occur?nohttps://cassyni.com/events/AKmfEmjiKn9BCHPHADczQm?videoPreview=12026-05-06T17:00:00+00:002175.16Cambridge PrismsThe possibility of human extinction has received growing academic attention over the last several decades. Research has analysed possible pathways to human extinction, as well as ethical considerations relating to human survival. Potential causes of human extinction can be loosely grouped into exogenous threats such as an asteroid impact and anthropogenic threats such as war or a catastrophic physics accident. In all cases, an outcome as extreme as human extinction would require events or developments that either have been of very low probability historically or are entirely unprecedented. This introduces deep uncertainty and methodological challenges to the study of the topic. This review provides an overview of potential human extinction causes considered plausible in the current academic literature, experts’ judgements of likelihood where available and a synthesis of ethical and social debates relating to the study of human extinction.https://cassyni-user-files-prod.s3.amazonaws.com/FYvE1yZc35w9Q8u79Di9yg https://cassyni.com/slides/outline/WaP4FRn7iumeinNqyTGgrq https://cassyni.com/events/WaP4FRn7iumeinNqyTGgrq/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Q9c5nuE3zaew8heaGvgGm4 https://cassyni.com/events/WaP4FRn7iumeinNqyTGgrq?videoPreview=1 G4 – Research Analytics Dashboards: Visualizing Faculty Performance Data for Actionable Insightsnohttps://cassyni.com/events/WaP4FRn7iumeinNqyTGgrq?videoPreview=12026-04-21T10:15:00+00:003043.84Research Analytics SummitEffective academic management requires accurate, contextual data to drive decision – making; yet, current faculty performance metrics often lack an end – user focus and fail to provide actionable insights for faculty and academic leaders. This session outlines the development of a home – grown research analytics ecosystem leveraging Power BI. The system features a publication aggregator using OpenAlex data to track research output by author, unit, and college. These data are integrated into a centralized "Faculty Dashboard" that visualizes key performance indicators beyond publications, including grant submissions, awards, and extramural/institutional salary coverage, over time. By superimposing unit – level trends within the dashboard, the system enables real – time benchmarking for faculty, chairs, and deans. Furthermore, we discuss the practical application of this system in a piloted annual review process, where research analytics are combined with user – entered data on teaching and service to generate holistic year – end reports. This approach reduces administrative burden on faculty and evaluators while providing third – party generated scholarly data to ensure consistent, equitable assessments for feedback and goal setting. While Power BI is the platform that will be used for demonstration, these insights are applicable to other dashboard platforms.https://cassyni-user-files-prod.s3.amazonaws.com/Q9c5nuE3zaew8heaGvgGm4 https://cassyni.com/events/GFaXuc1tzdi5Qcd2ZEjkaR/seminar/qa https://cassyni.com/slides/outline/GFaXuc1tzdi5Qcd2ZEjkaR https://cassyni.com/events/GFaXuc1tzdi5Qcd2ZEjkaR/abstract https://cassyni-user-files-prod.s3.amazonaws.com/8CoSs11EXv9Z6KXTWeEsae https://cassyni.com/events/GFaXuc1tzdi5Qcd2ZEjkaR?videoPreview=1 De-Extinction Beyond Species: Restoring Ecosystem Functionality through Large Herbivore Rewildingnohttps://cassyni.com/events/GFaXuc1tzdi5Qcd2ZEjkaR?videoPreview=12026-06-16T14:00:00+00:001814.68Cambridge PrismsThis perspective positions rewilding as a novel approach to ecosystem restoration, emphasising the restoration of natural processes to create self-willed ecosystems. Central to European rewilding is the de-domestication of cattle and horses to act as functional analogues of the extinct aurochs and wild horses. This de-extinction pathway shifts the focus from the loss of species to the loss of their ecological roles caused by human actions commencing millennia ago. The focus on restoring functional effects provides a strong policy rationale for large herbivore de-domestication, aligning with nature-based solutions to address environmental challenges. This alignment requires a pragmatic approach that prioritises the restoration of ecosystem functions over genetic purity and offers flexibility and scalability in rewilding efforts. I argue that creating a new category of ‘ecosystem engineer’ livestock is more effective than seeking wild status for these animals. As they are released into recovering ecosystems, de-domesticated large herbivores are recreating their ecological roles, ‘life-spheres’ and interactions. These processes open new avenues in both extinction discourse and ecological theory and encourage us to explore how de-extinct species can drive the recovery of European ecosystems.https://cassyni-user-files-prod.s3.amazonaws.com/8CoSs11EXv9Z6KXTWeEsae https://cassyni.com/events/V6TsE1MRou33B5RgpJmpaR/abstract https://cassyni-user-files-prod.s3.amazonaws.com/25yYocJUBfQg47Vxjiym1Y https://cassyni.com/events/V6TsE1MRou33B5RgpJmpaR?videoPreview=1 Episode 7: A Conversation with Nicole Scheffnohttps://cassyni.com/events/V6TsE1MRou33B5RgpJmpaR?videoPreview=12025-11-25T09:00:00+00:002333.64Advanced ScienceAbstract not yet added.https://cassyni-user-files-prod.s3.amazonaws.com/25yYocJUBfQg47Vxjiym1Y https://cassyni.com/slides/outline/QA1SsoQ4pgRTsSRFZdGE2R https://cassyni.com/events/QA1SsoQ4pgRTsSRFZdGE2R/abstract https://cassyni-user-files-prod.s3.amazonaws.com/9VR7v1ahc1dQxyBjNqRD3U https://cassyni.com/events/QA1SsoQ4pgRTsSRFZdGE2R?videoPreview=1 “Aria” Interview: The Greenhouse as Contextnohttps://cassyni.com/events/QA1SsoQ4pgRTsSRFZdGE2R?videoPreview=12021-02-11T06:00:00+00:00152.92Hong Kong Baptist University"The greenhouse is a potent venue for addressing climate change." Let’s see how "Aria" unfolds at the Hong Kong Park’s Forsgate Conservatory to tell the plight of our closest friend - Air.https://cassyni-user-files-prod.s3.amazonaws.com/9VR7v1ahc1dQxyBjNqRD3U https://cassyni.com/events/JisoNHHHzeLPUaB1xiGS2y/seminar/qa https://cassyni.com/slides/outline/JisoNHHHzeLPUaB1xiGS2y https://cassyni.com/events/JisoNHHHzeLPUaB1xiGS2y/abstract https://cassyni-user-files-prod.s3.amazonaws.com/M1vYcRA8KycEwe2AdQwTHx https://cassyni.com/events/JisoNHHHzeLPUaB1xiGS2y?videoPreview=1 Talk session 5: Applications – Fluids & Fusionnohttps://cassyni.com/events/JisoNHHHzeLPUaB1xiGS2y?videoPreview=12026-06-09T15:00:00+00:004405.44Nektar++ Development TeamThis seminar presented three distinct contributions to advanced computational fluid dynamics. The first addressed simulation of the tokamak plasma edge, a critical region for fusion due to extreme temperature gradients (100 million K to 1000 K) and complex multi-physics phenomena. The multispecies hybrid plasma code PENKNIFE, integrating Nektar++ for finite element fluid dynamics and NESO-Particles (VANTAGE-Reactions) for kinetic neutral transport, was presented. It solves Braginskii equations and demonstrated good agreement with EIRENE/SOLPS codes for neutral transport, laying groundwork for 3D turbulent simulations on GPU-accelerated supercomputers. The second presentation investigated the influence of gaps on aircraft surfaces on boundary-layer transition. Numerical simulations of 2D incompressible flow accurately reproduced experimental N-factor amplification (Δn_gap) from 3D low-Mach experiments. Findings indicated that 2D instabilities drive transition, leading to bypass transition at the gap's downstream edge. While increased Mach number generally destabilises deep gaps, it delays transition for shallow ones, with an unexplained anomaly at Mach 0.8. Future work includes developing a compressible linear stability solver. The final presentation introduced a consistent pressure-correction splitting scheme for incompressible flow using a least-squares finite element method. This three-step scheme explicitly projects an intermediate velocity onto a divergence-free space, proving computationally efficient and essential for accuracy. It achieves second-order convergence for manufactured solutions and successfully simulated the Taylor-Green vortex and cylinder flow (Re=400), capturing 2D and 3D wake dynamics. Integration challenges with Galerkin-based codes were noted, particularly regarding the accurate transfer of source term derivatives.https://cassyni-user-files-prod.s3.amazonaws.com/M1vYcRA8KycEwe2AdQwTHx https://cassyni.com/events/Ng7sy1VGK2cd9Rvic9bXeu/abstract https://cassyni-user-files-prod.s3.amazonaws.com/WzzfNBapdbRneXatutjh3C https://cassyni.com/events/Ng7sy1VGK2cd9Rvic9bXeu?videoPreview=1 Towards reconfigurable soft acoustic metalensesnohttps://cassyni.com/events/Ng7sy1VGK2cd9Rvic9bXeu?videoPreview=12026-07-20T08:00:00+00:001385.2MetaMatWe recently demonstrated that the acoustic index of soft porous materials can vary over a wide range of values by playing with their porosity. This has enabled us to manufacture a new generation of metalenses, known as soft gradient-index metasurfaces, designed to the manipulation of ultrasonic wavefronts for underwater applications. In this presentation, I will show that it is now possible to modulate the properties of these acoustic devices, such as their focal length, in a reversible manner using external stimuli such as UV radiation or a temperature field.https://cassyni-user-files-prod.s3.amazonaws.com/WzzfNBapdbRneXatutjh3C https://cassyni.com/events/ApazyEUZBQFdkSSeM13VyF/abstract https://cassyni-user-files-prod.s3.amazonaws.com/6WKxh6w1CmK1omfAXYLWjY https://cassyni.com/events/Li2fqcB7oh5K5mhekPA3cZ/seminar/qa https://cassyni.com/slides/outline/Li2fqcB7oh5K5mhekPA3cZ https://cassyni.com/events/Li2fqcB7oh5K5mhekPA3cZ/abstract https://cassyni-user-files-prod.s3.amazonaws.com/T2YmeStv7rLmL1XMtbDy9G https://cassyni.com/events/Li2fqcB7oh5K5mhekPA3cZ?videoPreview=1 New Insights Into Antibody Neutralization of Human Astrovirusnohttps://cassyni.com/events/Li2fqcB7oh5K5mhekPA3cZ?videoPreview=12026-09-18T17:00:00+00:003614.0Journal of Virology Join us for the next Journal of Virology Seminar Series, where Rebecca DuBois and graduate student Adam Lentz will present their recent studies on human astrovirus interactions with neutralizing antibodies. **Learning Objectives:** By the end of this webinar, participants will be able to understand: * What human astroviruses are. * How neutralizing antibodies bind human astrovirus and block infection. * How structural studies on virus-host interactions can inform vaccine development. https://cassyni-user-files-prod.s3.amazonaws.com/T2YmeStv7rLmL1XMtbDy9G https://cassyni.com/events/CJLTJsovgFRqjksKuoQexV/abstract https://cassyni-user-files-prod.s3.amazonaws.com/8j5XVbd1AKgw2riKWr96Ln https://cassyni.com/slides/outline/HjViw2SaueSy1e9XCzazYV https://cassyni.com/events/HjViw2SaueSy1e9XCzazYV/abstract https://cassyni-user-files-prod.s3.amazonaws.com/FXpz8gWfrLH6vp9pjSoZsC https://cassyni.com/events/HjViw2SaueSy1e9XCzazYV?videoPreview=1 Insights Gained in the Hunt for Genital Herpes Vaccinesnohttps://cassyni.com/events/HjViw2SaueSy1e9XCzazYV?videoPreview=12026-03-30T14:30:00+00:003840.12Night Science InstituteGenital herpes, caused by Herpes Simplex Virus type 2 (HSV-2) and increasingly HSV-1, infects approximately half a billion people globally, often causing asymptomatic, recurrent disease and potentially contributing to dementia. Despite its prevalence, we do not have an effective vaccine against HSV-2, largely because it fails to elicit robust local mucosal immunity or to overcome viral immune evasion mechanisms. This study explores novel vaccination strategies by investigating the immune responses crucial for protection against genital herpes. Using mouse models, it was demonstrated that tissue-resident memory T cells (TRM) in the genital mucosa are essential for 100% protection against disease, secreting interferon-γ to block viral replication. CD4 T cells were found to initiate CD8 T cell migration to the mucosa via interferon-γ- induced chemokines (CXCL9, CXCL10) that bind to CXCR3. A "prime and pull" strategy was developed that combined systemic immunization with local delivery of chemokines to recruit virus-specific CD8 TRM cells. This approach protected mice from primary challenge and therapeutically reduced recurrent disease in guinea pigs, notably by engaging dendritic cells for antigen presentation, thereby circumventing HSV's MHC evasion. Further investigation revealed that CD4 T cells are critical for antibody access to neural tissues, the dorsal root ganglia (DRG), potentially by modulating blood-nerve barrier permeability through interferon-γ secretion, thereby blocking viral replication and latency establishment. Building on these insights, a novel nanoparticle system, BEACONs (bioactive enhanced adjuvant chemokine oligonucleotide nanoparticles), was engineered. Intravaginal BEACON delivery following an mRNA prime achieved 100% protection in mice, significantly reducing viral load in both the vaginal fluid and DRG for over 180 days, surpassing the efficacy of conventional prime-boost approaches. These findings underscore the importance of localized mucosal immunity and chemokine-driven cellular recruitment for effective and long-lasting protection against herpes simplex virus.https://cassyni-user-files-prod.s3.amazonaws.com/FXpz8gWfrLH6vp9pjSoZsC https://cassyni.com/slides/outline/R9DndH9TVWkoWDfzAsSixV https://cassyni.com/events/R9DndH9TVWkoWDfzAsSixV/abstract https://cassyni-user-files-prod.s3.amazonaws.com/7gKKMpDbfK5ZJXuK6FgYHC https://cassyni.com/events/R9DndH9TVWkoWDfzAsSixV?videoPreview=1 Plus ça change… responses of a very long-established oak forest to elevated CO₂nohttps://cassyni.com/events/R9DndH9TVWkoWDfzAsSixV?videoPreview=12025-08-05T10:00:00+00:001890.32None“The more things change, the more they stay the same…” is attributed to French writer Jean-Baptiste Alphonse Karr, and is usually considered a pessimistic condemnation of moral and social stasis. But in an ecological context and a rapidly changing world, coping (‘staying the same’) relates to resistance, recovery and resilience, and may be a hopeful sign, especially for ecosystems with long-lived plants at their core, like the oak woodland that is the site of the University of Birmingham’s Institute for Forest Research (BIFoR) Free-Air CO₂ Enrichment (FACE) facility. BIFoR FACE is set in UK broadleaf forest dominated by 175-year-old and 25 m tall oak trees interspersed with sycamore, hazel, hawthorn, and holly. CO₂-enrichment, scheduled to run until 2031, commenced in spring 2017. The whole canopy volume of three 30m-diameter plots is immersed in air containing 150 ppm CO₂ above current atmospheric levels throughout growing season daylight hours. Three neighbouring plots act as controls. Effects of elevated CO₂ found in BIFoR FACE include: (i) 20% greater season-average photosynthesis; (ii) 10% greater woody dry mass increment; and (iii) a faster, more conservative nitrogen cycle with 74% reduction in N₂O emissions. This ‘faster-tighter’ N-cycling in the forest allows leaf quality (C:N) to be maintained even as more carbon is assimilated. Accompanying this forest productivity response is evidence of nascent ecosystem fragility. Susceptibility to powdery mildew and insect herbivory is unchanged in the mature trees but increased in seedlings. Pollen and flower mineral contents are significantly reduced under eCO₂, and acorns contain significantly less protein but more phytic acid. These more ecologically problematic findings imply a carbon-rich, nutrient-poor, future diet for animals and insects in temperate forest ecosystems.https://cassyni-user-files-prod.s3.amazonaws.com/7gKKMpDbfK5ZJXuK6FgYHC https://cassyni.com/slides/outline/TcTorhP5goXHsA9YiZMMgR https://cassyni.com/events/TcTorhP5goXHsA9YiZMMgR/abstract https://cassyni-user-files-prod.s3.amazonaws.com/GqjmeY8RG73hMFDwLF21FC https://cassyni.com/events/TcTorhP5goXHsA9YiZMMgR?videoPreview=1 Energy Technology and Innovation Panelnohttps://cassyni.com/events/TcTorhP5goXHsA9YiZMMgR?videoPreview=12013-09-19T06:00:00+00:003327.0 School of Public PolicyC3E Women in Clean Energy Symposium 2013: Panel on the most effective ways of moving game changing energy technologies from the lab to the marketplace. Panelists include Marilyn Brown, Georgia Institute of Technology; C3E Ambassador Cheryl Martin, ARPA-E; C3E Ambassador Alla Weinstein, Principle Power, Inc.; and Renata Mele, Enel Foundation.https://cassyni-user-files-prod.s3.amazonaws.com/GqjmeY8RG73hMFDwLF21FC https://cassyni.com/slides/outline/Co1gUByLX4ufZDrqhuXd8h https://cassyni.com/events/Co1gUByLX4ufZDrqhuXd8h/abstract https://cassyni-user-files-prod.s3.amazonaws.com/7ChRnxsrB2WkbQ271xTrra https://cassyni.com/events/Co1gUByLX4ufZDrqhuXd8h?videoPreview=1 Indexing the World’s Research Talks (Lightning Talk)nohttps://cassyni.com/events/Co1gUByLX4ufZDrqhuXd8h?videoPreview=12026-02-24T11:30:00+00:00407.6Researcher to ReaderWe index papers, datasets and code, but not the conversations that shape them. A global index of research talks would unlock faster discovery, more engaging institutional repositories, and richer journal communities. It would also strengthen trust through provenance: who said what, when, in what context, linked directly to the underlying work.https://cassyni-user-files-prod.s3.amazonaws.com/7ChRnxsrB2WkbQ271xTrra https://cassyni.com/slides/outline/PfJbbrimaW1sDyPGc1hki9 https://cassyni.com/events/PfJbbrimaW1sDyPGc1hki9/abstract https://cassyni-user-files-prod.s3.amazonaws.com/A6DfXwYa8XW8GXh8ESnEiA https://cassyni.com/events/PfJbbrimaW1sDyPGc1hki9?videoPreview=1 B2 – Tackling Last Minute Requests – Building Research Analytics Expertise through Cross – Unit Collaborationnohttps://cassyni.com/events/PfJbbrimaW1sDyPGc1hki9?videoPreview=12026-04-20T10:15:00+00:002688.08Research Analytics SummitResearch administration and Development (RAD) offices often face labor – intensive data tasks, particularly when responding to leadership requests under tight deadlines. At Tufts University, RAD handles substantial award and proposal data. This involves critical staff performing manual tasks, such as identifying active researchers, reconciling name variations, and generating reports. These tasks significantly strain the office’s workload, hindering its ability to engage in more valuable analytics. Automating these tasks allows a shift toward higher – value analytics. RAD collaborated with a peer department to build Python – based tools for automating principal investigator data cleaning. This collaboration enabled rapid production of active researcher lists and created a structured dataset which can support advanced analytics, such as tracking engagement, forecasting award expirations, and developing departmental insights for strategic planning. This session will walk attendees through the transformation from manual data handling to a scalable, automated analytics pipeline. Emphasizing cross unit collaboration, the presentation will highlight how pairing staff with knowledge of available research administration data with colleagues skilled in coding and data analytics can produce credible, actionable insights. Participants will leave with a practical model for reducing administrative burden, improving data quality, and expanding research analytics capacity.https://cassyni-user-files-prod.s3.amazonaws.com/A6DfXwYa8XW8GXh8ESnEiA https://cassyni.com/slides/outline/8qrUDMK2QmQEv36ZbMt2AR https://cassyni.com/events/8qrUDMK2QmQEv36ZbMt2AR/abstract https://cassyni-user-files-prod.s3.amazonaws.com/KvFcRmmaAp9AoujbYUHP34 https://cassyni.com/events/8qrUDMK2QmQEv36ZbMt2AR?videoPreview=1 Being Human Speakers: What did you discuss on the panel?nohttps://cassyni.com/events/8qrUDMK2QmQEv36ZbMt2AR?videoPreview=12018-10-05T06:00:00+00:0091.32NoneIn 2017 we teamed up with Being Human, a national festival dedicated to demonstrating the breadth, diversity and vitality of the humanities, led by the School of Advanced Study, University of London in partnership with the Arts & Humanities Research Council and the British Academy. We hosted a lively panel discussion which examined the evolution of gay, lesbian and queer representation across history, literature and media. Our panellists delved into what it has meant to be a ‘lost’, marginalised and even criminalised voice, and examined to what degree historically marginalised voices have been ‘found’ since this momentous Act of Parliament was passed.https://cassyni-user-files-prod.s3.amazonaws.com/KvFcRmmaAp9AoujbYUHP34 https://cassyni.com/events/XZhtTRb41BoXY1uFMzgTJM/seminar/qa https://cassyni.com/slides/outline/XZhtTRb41BoXY1uFMzgTJM https://cassyni.com/events/XZhtTRb41BoXY1uFMzgTJM/abstract https://cassyni-user-files-prod.s3.amazonaws.com/DLXrDWPC1L32RAAH5Yugh4 https://cassyni.com/events/XZhtTRb41BoXY1uFMzgTJM?videoPreview=1 How to publish a journal article: An APA Journals webinar for the Japanese Psychological Associationnohttps://cassyni.com/events/XZhtTRb41BoXY1uFMzgTJM?videoPreview=12026-05-14T11:00:00+00:002792.88NoneJoin this interactive webinar, intended for the Japanese Psychological Association (JPA) members, featuring insights on how to publish a journal article. Dr. Katsunori Yamada, Editor of APA's [*Journal of Neuroscience, Psychology, and Economics*](https://apa.org/pubs/journals/npe), will share his expertise and provide tips for international authors.https://cassyni-user-files-prod.s3.amazonaws.com/DLXrDWPC1L32RAAH5Yugh4 https://cassyni.com/slides/outline/7MwHBvtLVkfdNL9QSDP9t1 https://cassyni.com/events/7MwHBvtLVkfdNL9QSDP9t1/abstract https://cassyni-user-files-prod.s3.amazonaws.com/EJesJViC6FGCyq2s5aEB3k https://cassyni.com/events/7MwHBvtLVkfdNL9QSDP9t1?videoPreview=1 She Works Hard For The Money: Black Women Entrepreneurs Business Networks and Entrepreneurial Successnohttps://cassyni.com/events/7MwHBvtLVkfdNL9QSDP9t1?videoPreview=12025-11-19T15:00:00+00:00980.92Center for Black Entrepreneurship, Spelman CollegeThis study investigates the paradox of Black women entrepreneurs, who start businesses at six times the national average yet face severe undercapitalization and undersupport, owning 20% of all women-owned firms but experiencing persistent disparities in revenue, size, and survival rates. The research explores how engagement in various business networks influences the success of Black women-owned businesses, differentiating between informal and formal, heterogeneous and homogeneous, and digital and in-person networks. A mixed-methods approach with an interpretive epistemology was employed, involving 28 in-depth interviews (60-90 minutes) analyzed using the Gioia method, followed by a survey developed from qualitative insights and validated measures. Comparative interviews with other demographic groups were also conducted. Key findings indicate that Black women entrepreneurs navigate networks with strong self-efficacy, often rooted in religious faith, despite facing systematic barriers such as gatekeeping and performative inclusion. Success is frequently defined not by immediate financial metrics but by legacy, intergenerational wealth creation, and community impact. Network agility, defined as the ability to bridge both formal and informal networks, is crucial for effectiveness. Practical implications include advocating for investors and funds to prioritize founders demonstrating self-efficacy and strengthening government programs like WOSB, HUBZone, and 8(a). A RISE framework (Resource building, Intentional visibility, Support of community, Entrepreneurial self-efficacy) is proposed to help founders access high-value supply chains. Furthermore, nonprofit and community organizations are encouraged to design trust-centered, culturally responsive support that fosters confidence and skills-building for legitimacy and visibility, noting that online communities were found to be more prone to bias than in-person interactions.https://cassyni-user-files-prod.s3.amazonaws.com/EJesJViC6FGCyq2s5aEB3k https://cassyni.com/slides/outline/EH1jqVwgeARQs98yoex62h https://cassyni.com/events/EH1jqVwgeARQs98yoex62h/abstract https://cassyni.com/events/EH1jqVwgeARQs98yoex62h?videoPreview=1 Data-Driven Dynamic Factor Modelingvia Manifold Learningnohttps://cassyni.com/events/EH1jqVwgeARQs98yoex62h?videoPreview=12026-05-18T01:00:00+00:003055.12Risk SciencesWe introduce a data-driven dynamic factor framework for modeling the joint evolution of high-dimensional covariates and responses without parametric assumptions. Standard factor models applied to covariates alone often lose explanatory power for responses. Our approach uses anisotropic diffusion maps, a manifold learning technique, to learn low-dimensional embeddings that preserve both the intrinsic geometry of the covariates and the predictive relationship with responses. For time series arising from Langevin diffusions in Euclidean space, we show that the associated graph Laplacian converges to the generator of the underlying diffusion. We further establish a bound on the approximation error between the diffusion map coordinates and linear diffusion processes, and we show that ergodic averages in the embedding space converge under standard spectral assumptions. These results justify using Kalman filtering in diffusion-map coordinates for predicting joint covariate-response evolution. We apply this methodology to equity-portfolio stress testing using macroeconomic and financial variables from Federal Reserve supervisory scenarios, achieving mean absolute error improvements of up to 55% over classical scenario analysis and 39% over principal component analysis benchmarks. [Risk sciences](https://www.keaipublishing.com/en/journals/risk-sciences/) aims to foster diverse, multidisciplinary insights in risk sciences, bridging theory and practice through a series of academic activities. This speech record is an excerpt from Prof. Agostino Capponi 's keynote speech for the China Conference on Insurance and Risk Management, which was held on July 9-12, 2025, in Urumqi, China. https://cassyni.com/slides/outline/FGLa3VkcvSTHggFEA2yBhP https://cassyni.com/events/FGLa3VkcvSTHggFEA2yBhP/abstract https://cassyni-user-files-prod.s3.amazonaws.com/25td9pGaAKAgbF4iqp66VU https://cassyni.com/events/FGLa3VkcvSTHggFEA2yBhP?videoPreview=1 Science Advocacy in Action: Targeting Zikanohttps://cassyni.com/events/FGLa3VkcvSTHggFEA2yBhP?videoPreview=12025-05-22T06:00:00+00:00326.64Journal of VirologyWhy does vaccine design matter in the fight against emerging viruses? The Journal of Virology Seminar Series highlights science advocacy and innovation in its latest webinar, “Targeting Zika: Virus-Like Particle Vaccines with Authentic Quaternary Epitopes for Enhanced Protection.” Researchers Gorben Pijlman and Monique van Oers share how their work advancing a next-generation Zika vaccine reflects the importance of long-term investment in basic science, global collaboration, and public trust in research. From refining virus-like particle design to overcoming early failures, their story underscores how scientific persistence drives innovation and strengthens our collective ability to respond to future outbreaks. https://cassyni-user-files-prod.s3.amazonaws.com/25td9pGaAKAgbF4iqp66VU https://cassyni.com/slides/outline/Qegg37ZUfVuHguQmMjPCCd https://cassyni.com/events/Qegg37ZUfVuHguQmMjPCCd/abstract https://cassyni-user-files-prod.s3.amazonaws.com/3CzJRvViZvtJRPTyCQU8r2 https://cassyni.com/events/Qegg37ZUfVuHguQmMjPCCd?videoPreview=1 Generative Diffusion Models for Synthesis and Reconstruction of Stochastic Signals in Complex Multiscale Systemsnohttps://cassyni.com/events/Qegg37ZUfVuHguQmMjPCCd?videoPreview=12026-05-21T07:00:00+00:003628.04The Edinburgh Fluid Dynamics Group (EFDG)We introduce a stochastic generative framework for the reconstruction and augmentation of complex, multiscale signals arising in nonlinear dynamical systems. The approach builds on generative Diffusion Models, a class of probabilistic deep learning methods capable of learning high-dimensional data distributions beyond Gaussian approximations. We demonstrate applications to both two-dimensional fields and one-dimensional stochastic signals, including the temporal evolution of turbulent observables along Lagrangian particle trajectories and sea-surface fields derived from satellite imagery. Particular emphasis is placed on the faithful reproduction of non-Gaussian statistics, intermittency, extreme events, and scale-dependent correlations. We further present preliminary results on generalization capabilities, robustness to model collapse, and the intrinsic limitations of black-box generative approaches in physics-driven contexts. Finally, we discuss long-term perspec-tives on data-driven stochastic modeling for complex systems, outlining key methodological challenges and the transformative potential of generative AI for advancing the quantitative modeling of chaotic and stochastic systems and related multiscale phenomena. https://cassyni-user-files-prod.s3.amazonaws.com/3CzJRvViZvtJRPTyCQU8r2 https://cassyni.com/slides/outline/KiCdaH6EGvNGHohRMFgCUV https://cassyni.com/events/KiCdaH6EGvNGHohRMFgCUV/abstract https://cassyni-user-files-prod.s3.amazonaws.com/WdNm6QsxSCzVD7ea2EigE https://cassyni.com/events/KiCdaH6EGvNGHohRMFgCUV?videoPreview=1 Extreme heat across the soil, plant, animal, atmosphere continuumnohttps://cassyni.com/events/KiCdaH6EGvNGHohRMFgCUV?videoPreview=12026-06-02T11:30:00+00:001732.08The biotic impact of a heatwave is highly contextual; it depends on the magnitude and duration of the event, the exposure and sensitivity of the organisms of interest, and the biophysical state of the landscape. Vegetation has a strong and complex influence on all these contextual factors, with feedbacks mediated by transpiration and leaf temperature. Our ability to predict heatwave impacts on any particular organism therefore hinges on our general understanding of plant environmental responses. In this talk I will give an overview of modelling approaches my group has been developing to capture these interactions across the soil, plant, animal, atmosphere continuum, including the development of a biophysical modelling ecosystem in the Julia programming environment. I will include empirical examples drawing from heat waves in southern Australia, including the recent January 2026 event.https://cassyni-user-files-prod.s3.amazonaws.com/WdNm6QsxSCzVD7ea2EigE https://cassyni.com/slides/outline/SdH6Dr9aRL83ncgzihF8dB https://cassyni.com/events/SdH6Dr9aRL83ncgzihF8dB/abstract https://cassyni-user-files-prod.s3.amazonaws.com/2VvarThvqMKEWQU6WCVW3g https://cassyni.com/events/SdH6Dr9aRL83ncgzihF8dB?videoPreview=1 Designing urban landscapes to cope with a hotter worldnohttps://cassyni.com/events/SdH6Dr9aRL83ncgzihF8dB?videoPreview=12026-06-04T13:00:00+00:002040.64Urban heat islands often reach temperatures that are 8 – 10 °C above surrounding rural locations due to heat absorbing infrastructure that can achieve surface temperatures of over 80 °C. Intensifying heatwaves coupled with urban heat islands is among the most profound climate-caused human health threats around the globe, causing hundreds of thousands of deaths per year world-wide. As a consequence. mitigating the effects of urban heat islands is now recognized as one of societies grand challenges for improving human health and enterprise. Using the city of Phoenix as a case study, this presentation highlights the challenges and opportunities for expanding urban greenspace, and reducing urban heat islands in one of the hottest major cities on the planet. Similar to many urban landscapes, Phoenix is located in a region where water demand dramatically outpaces local water reserves, thus, requiring water conservation strategies that potentially reduces opportunities for green infrastructure planning, implementation and maintenance. This presentation introduces novel technologies and opportunities using next-generation sensor arrays, phenotyping and remote monitoring to establish the smartest and most effective green infrastructure possible to mitigate urban heat islands given limited water resources.https://cassyni-user-files-prod.s3.amazonaws.com/2VvarThvqMKEWQU6WCVW3g https://cassyni.com/events/5t3iH8yXz6rnedEiSaKnjf/abstract https://cassyni-user-files-prod.s3.amazonaws.com/UDRkh8o56fT5y4V59qrMmp https://cassyni.com/slides/outline/Co9o3LYmXsYJHuvh6aqAWy https://cassyni.com/events/Co9o3LYmXsYJHuvh6aqAWy/abstract https://cassyni-user-files-prod.s3.amazonaws.com/CCQ8LnNT3tYmKhw3QbesX4 https://cassyni.com/events/Co9o3LYmXsYJHuvh6aqAWy?videoPreview=1 Exhaust dynamics of pellet-fueled plasmas in the DIII-D tokamaknohttps://cassyni.com/events/Co9o3LYmXsYJHuvh6aqAWy?videoPreview=12026-08-27T15:00:00+00:002470.28Journal of Plasma PhysicsCryogenic pellet injection provides a fueling solution for magnetic confinement fusion reactors that promotes fueling efficiency and plasma performance, to maximize tritium burn-up and fusion reactions. However, the discrete nature of this fueling source poses a risk to the steady state power handling of future reactors. Future reactors will require a continuously detached divertor with minimal thermal cycling to ensure longevity of wall materials. Pellet-induced divertor transients risk detachment burn-through [Wiesen et al. Nucl. Fusion 57 (2017)] and so must be understood and controlled. Two differing transient divertor responses to pellet fueling are observed in DIII-D experiments. The peak target heat flux either reduces or increases, with up to 25% variation over 25-50ms. Time-dependent SOLPS-ITER simulations qualitatively reproduce both responses and highlight the role of pellet deposition depth. Shallow pellet deposition results in a quick rise in the radial particle and heat fluxes crossing the separatrix ($\Delta\Gamma_{SOL}$, $\Delta P_{SOL}$ respectively) due to increased convection. While $\Delta P_{SOL}$ directs more power into the divertor, $\Delta\Gamma_{SOL}$ leads to enhanced detachment processes that ultimately reduce target heat flux and T$_e$. On the other hand, deeper pellet deposition can lead to an increase in target heat flux as the conductive $P_{SOL}$ increases while $\Delta\Gamma_{SOL}$ remains small. Simulations in DIII-D suggest that target variations can be reduced by over 5x by dampening the response of $\Gamma_{SOL}$, $P_{SOL}$, achieved by tuning pellet depth. https://cassyni-user-files-prod.s3.amazonaws.com/CCQ8LnNT3tYmKhw3QbesX4 https://cassyni.com/events/3uWYKfRD2zVrFdT4yZUZpZ/seminar/qa https://cassyni.com/slides/outline/3uWYKfRD2zVrFdT4yZUZpZ https://cassyni.com/events/3uWYKfRD2zVrFdT4yZUZpZ/abstract https://cassyni-user-files-prod.s3.amazonaws.com/8Njig7son4qm4twdpYhGE2 https://cassyni.com/events/3uWYKfRD2zVrFdT4yZUZpZ?videoPreview=1 Dispersion of reacting settling particles in ice-covered channels: transient behaviour and asymptotic analysisnohttps://cassyni.com/events/3uWYKfRD2zVrFdT4yZUZpZ?videoPreview=12026-09-15T08:00:00+00:004258.36Royal Society PublishingThis study investigates the dispersion of reacting fine settling particles in ice-covered channels, considering both laminar and turbulent flow regimes. The concentration distribution and transport dynamics of fine settling particles are analysed by incorporating the combined effects of settling velocity and reaction rate. Unlike previous studies, this work extends Mei’s multiscale homogenization approach to incorporate the effect of settling velocity on long time dispersion. The transient behaviour of the transport process, including advection, dispersion, skewness, kurtosis and concentration distribution, is analysed using Aris’s method of moments. In addition, an implicit finite-difference scheme is employed to validate the analytical results, demonstrating good agreement. The present results predict that increasing the reaction rate reduces the total mass in the flow, while the dispersion characteristics remain unaffected. An increase in particle settling velocity enhances upstream movement in both laminar and turbulent flows. However, this effect is predicted to be more pronounced under turbulent conditions. In the presence of the settling velocity, the particles tend to form a concentrated layer near the channel bed, which can eventually lead to the accumulation of pollutants and sediments. This behaviour poses a serious risk to the aquatic environment. Understanding the dispersion of reacting and settling particles is essential for managing environmental pollution in ice-covered rivers, estuaries and similar systems.https://cassyni-user-files-prod.s3.amazonaws.com/8Njig7son4qm4twdpYhGE2 https://cassyni.com/events/GkqqU8zvJ2eAJ7EyMGa11f/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Wx4DgrGisyCvNojuzBGGkn https://cassyni.com/slides/outline/8sXq58ECaQyqjR9FPygX6D https://cassyni.com/events/8sXq58ECaQyqjR9FPygX6D/abstract https://cassyni-user-files-prod.s3.amazonaws.com/4ZcW8pFqz814nGK4qXBssL https://cassyni.com/events/8sXq58ECaQyqjR9FPygX6D?videoPreview=1 Organic Stress: A Tool for Chemical Synthesisnohttps://cassyni.com/events/8sXq58ECaQyqjR9FPygX6D?videoPreview=12025-01-24T13:00:00+00:003592.84Thieme India ChemTalksRing-strain in organic molecules is a powerful driving force that promotes reactivity through strain-release, allowing the facile construction of a myriad of useful scaffolds via ring-opening or ring-expansion reactions. Carbene chemistry has been widely studied and found numerous applications in organic synthesis such as X–H (X = C, Si, N, O, etc.) insertions, cyclopropanations, ylide formations, and 1,2-migrations. Due to their high reactivity, carbenes are also ideal for initiating a cascade sequence, leading to rapid generation of structural complexity. In this talk, I will first discuss strain-enabled radical cascades for synthesizing functionalized spirocyclobutyl lactones, – lactams, and -oxindoles. To introduce a more diverse set of functional groups, we have developed a dual photoredox/nickel system capable of mediating the carbosulfonylation of BCB allyl amides. In the second part, I will talk about how we merged strain-release and metal-carbene chemistry to unlock new strategies for organic synthesis. A copper-catalyzed highly diastereoselective strain-release [2,3]-sigmatropic rearrangement will be discussed first. Then, I will show how we utilized the ring strain in [1.1.1]propellane to access copper-carbenes for [2,3]-sigmatropic rearrangement. In the end, I will focus on rhodium-catalyzed strain-enabled stereoselective synthesis of skipped dienes. *Key takeaways for the attendees:* * Strain-Enabled Radical Spirocyclization Cascades * Merging Ring-Strain and Carbene Chemistry * Diastereoselective Doyle-Kirmse reaction * Harnessing Carbene Reactivity of BCB and [1.1.1]Propellane * New strategies for Methylenecyclopropanes and Methylenecyclobutanes https://cassyni-user-files-prod.s3.amazonaws.com/4ZcW8pFqz814nGK4qXBssL https://cassyni.com/events/JjpyFgoRguq6VEXRNj47KT/seminar/qa https://cassyni.com/slides/outline/JjpyFgoRguq6VEXRNj47KT https://cassyni.com/events/JjpyFgoRguq6VEXRNj47KT/abstract https://cassyni-user-files-prod.s3.amazonaws.com/HVFVrZZutVv7p5us57W1Mp https://cassyni.com/events/JjpyFgoRguq6VEXRNj47KT?videoPreview=1 Artificial Intelligence in Dialysis Carenohttps://cassyni.com/events/JjpyFgoRguq6VEXRNj47KT?videoPreview=12024-03-15T11:30:00+00:003922.16Imperial College Renal and Transplant CentreToday, in our everyday lives, artificial intelligence (AI) applications are omnipresent, from voice recognition to route planning, fraud protection, and on-line shopping recommendations. The pervasiveness of AI in our personal lives begets the question “What is the role of AI in dialysis care?”. In dialysis care, three main application areas for “classical” AI (i.e., non-generative AI) have emerged [1]: prediction, therapy recommendation, and diagnosis. Examples are the prediction of hospital admissions and prediction of intradialytic hypotension in real-time. The former was implemented already in clinical practice and resulted in a lower hospitalization rate [2]. The latter involves the cloud-based integration of dialysis machine data, and electronic health records with AI-powered prediction algorithms [3]. In several countries AI applications are used to give anemia therapy recommendations [4] that are subsequently reviewed by health care providers prior to prescription. The application of such an AI tool has resulted in improved attainment of target hemoglobin targets, less severe anaemia, and lower ESA utilization [5]. Regarding diagnostics, AI systems have been developed to categorize arterio-venous aneurysms as advanced / non-advanced [6]. In addition, natural language processing, an AI method to extract insights from health care provider notes, has been shown to be superior to billing codes to identify symptom burden in hemodialysis patients [7]. The recent advent of generative AI and large language models (LLM) such as ChatGPT has instigated research into applications in dialysis care. For example, LLMs are explored to support renal dietitians and provide better personalized care. So far, results have shown only moderate performance of LLMs [8]. It is expected that AI applications, both “classical” and “generative”, will be expanded in the future. Moving forward, it will be critically important to recognize potential flaws of AI systems, such as biases and it “black box” character, and to respect ethical and privacy concerns.https://cassyni-user-files-prod.s3.amazonaws.com/HVFVrZZutVv7p5us57W1Mp https://cassyni.com/slides/outline/HGVrdVCMEUYk1ZChDWGXJ5 https://cassyni.com/events/HGVrdVCMEUYk1ZChDWGXJ5/abstract https://cassyni-user-files-prod.s3.amazonaws.com/LNeg3yJi5ta7HAwoPsqim4 https://cassyni.com/events/HGVrdVCMEUYk1ZChDWGXJ5?videoPreview=1 Antiphospholipid syndrome: potential link between the gut and autoimmunitynohttps://cassyni.com/events/HGVrdVCMEUYk1ZChDWGXJ5?videoPreview=12024-09-19T13:00:00+00:00646.0Microbiome Virtual International ForumAntiphospholipid syndrome (APS) is an autoimmune disease of unclear etiology. Its estimated prevalence is 50 patients per 100,000 individuals and is caused by self targeting antiphospholipid antibodies that lead to an increased risk of thrombosis. Genetically predisposing factors are known, yet alone, cannot be decisive for the onset and severity of APS. Ruff et al., Cell Host Microbe, 2019, found that the gut microbiome is likely to be implicated in the development and persistence of autoimmunity in APS. They demonstrated cross-reactivity between non-orthologous mimotopes present in DNA methyltransferase (DNMT) expressed by a common human gut commensal Roseburia intestinalis and T and B cell autoepitopes in the APS autoantigen β2-glycoprotein I (β2GPI). Here we sequenced 79 stool microbiome samples from 19 APS patients and 16 healthy donors at nearly 100 million median number of reads, obaining a first ever metagenomic dataset for APS. We compare alpha- and beta-diversity between disease and healthy individuals and investigate previously identified R. intestinalis, as well as other known microbiome cardiolipin producers finding no differences. We search for proteins carrying the β2GPI autoepitopes via database search and direct search in the sequenced reads leading to discovery of many more potential epitope carriers needing further experimental confirmation.https://cassyni-user-files-prod.s3.amazonaws.com/LNeg3yJi5ta7HAwoPsqim4 https://cassyni.com/slides/outline/FGeRJRRNMQeHHvueJHJ3eD https://cassyni.com/events/FGeRJRRNMQeHHvueJHJ3eD/abstract https://cassyni-user-files-prod.s3.amazonaws.com/RH1yHLCnfBq3kaN4uv1aJJ https://cassyni.com/events/FGeRJRRNMQeHHvueJHJ3eD?videoPreview=1 Q&A: Relocating Africa — Representations and Memory of Africa in 20th and 21st Century Chinanohttps://cassyni.com/events/FGeRJRRNMQeHHvueJHJ3eD?videoPreview=12021-05-07T12:00:00+00:002904.44Hong Kong Baptist UniversityNo abstracthttps://cassyni-user-files-prod.s3.amazonaws.com/RH1yHLCnfBq3kaN4uv1aJJ https://cassyni.com/events/9qWmnuJbXNZCu4fQhNJFem/abstract https://cassyni-user-files-prod.s3.amazonaws.com/6afpzmAQpEf2N3dXxNkBZG https://cassyni.com/events/9qWmnuJbXNZCu4fQhNJFem?videoPreview=1 Trial and Error in the Transition from Graduate Student to Professornohttps://cassyni.com/events/9qWmnuJbXNZCu4fQhNJFem?videoPreview=12023-06-04T12:00:00+00:001258.24Hong Kong Baptist UniversityAs an early career scholar, it can feel like you have to work all the time to get ahead – or just to stay on top of things. But as guests Andrew Gambino and Drew Cingel explain in this episode of Growing Up Comm, balance is important.https://cassyni-user-files-prod.s3.amazonaws.com/6afpzmAQpEf2N3dXxNkBZG https://cassyni.com/slides/outline/7rvMcAiVmYLSoMPBLQSKED https://cassyni.com/events/7rvMcAiVmYLSoMPBLQSKED/abstract https://cassyni-user-files-prod.s3.amazonaws.com/8HkjsdaZDwZ1XfwN3t7CR4 https://cassyni.com/events/7rvMcAiVmYLSoMPBLQSKED?videoPreview=1 Sasi of Hennessynohttps://cassyni.com/events/7rvMcAiVmYLSoMPBLQSKED?videoPreview=12025-04-29T12:00:00+00:00113.04Hong Kong Baptist UniversityThe poem "Sasi of Hennessy," featured in the Provost's Poetry Prize anthology 2024, *Mingled Voices 9*, explores themes of romance and destiny within an urban Hong Kong setting. The title's elements are precisely defined: "Sasi" symbolises the moon, an apsara, or a celestial goddess, while "Hennessy" refers to Hennessy Road, a prominent two-way thoroughfare with tram services. This road serves as a significant backdrop, notably appearing in the 2010 film *Crossing Hennessy*, which portrays a love story between individuals from different sides of the road who overcome past romantic complexities. The poem employs this rich context to explore a narrative where a character named Sasi, initially isolated amidst urban density, experiences a profound romantic shift. The rising full moon acts as a pivotal symbolic element, described as conveying a "positive prophecy" and incubating "joyful encounters" with a "hard-to-resist, doomed transparency." A secret message, implicitly from a "romance embassy" via moonlight, triggers "irresistible ecstasy" in the protagonist, compelling her to pursue her heart's desire with "unregulated velocity." The work concludes by asserting that in a city steeped in "romantic legacy," emotional synchronicity culminates in "irresistible joy," thereby positing that "love at first sight" is a tangible reality rather than a mere fantasy.https://cassyni-user-files-prod.s3.amazonaws.com/8HkjsdaZDwZ1XfwN3t7CR4 https://cassyni.com/slides/outline/4QP8HPBphLTomf5cgk4MhP https://cassyni.com/events/4QP8HPBphLTomf5cgk4MhP/abstract https://cassyni-user-files-prod.s3.amazonaws.com/V5G6h6UYrAUNzzp4t6gfSN https://cassyni.com/events/4QP8HPBphLTomf5cgk4MhP?videoPreview=1 Gego: Speaking Exilenohttps://cassyni.com/events/4QP8HPBphLTomf5cgk4MhP?videoPreview=12022-04-07T12:00:00+00:003202.88Hong Kong Baptist UniversityDie eigenständige künstlerische Position von Gego bildete sich in intensiver Auseinandersetzung mit architektonischen Praktiken ihrer Zeit heraus. Die Bedeutung von »Herkunft und Begegnung« spielte dabei für die Exilkünstlerin eine zentrale Rolle. Gemeinsam mit internationalen Kunsthistoriker:innen, Kurator:innen und Architekturtheoretiker:innen wurden die professionellen und sozialen Kontexte, in welche Gego zunächst in Stuttgart und später in Caracas eingebettet war, betrachtet. Diese wurden vor dem Hintergrund der dort vorherrschenden Diskurse in Kunst und Architektur analysiert und in Bezug zu ihrer künstlerischen Praxis gestellt.https://cassyni-user-files-prod.s3.amazonaws.com/V5G6h6UYrAUNzzp4t6gfSN https://cassyni.com/slides/outline/NBJYEYkRTQWAbGsMRNB26R https://cassyni.com/events/NBJYEYkRTQWAbGsMRNB26R/abstract https://cassyni-user-files-prod.s3.amazonaws.com/X3ToH1rExwibdChSYs8vUv https://cassyni.com/events/NBJYEYkRTQWAbGsMRNB26R?videoPreview=1 Three Breath Meditationnohttps://cassyni.com/events/NBJYEYkRTQWAbGsMRNB26R?videoPreview=12020-04-09T12:00:00+00:00144.64Hong Kong Baptist UniversityNo abstracthttps://cassyni-user-files-prod.s3.amazonaws.com/X3ToH1rExwibdChSYs8vUv https://cassyni.com/slides/outline/QeYZTxz3ehGexDLuy45epM https://cassyni.com/events/QeYZTxz3ehGexDLuy45epM/abstract https://cassyni-user-files-prod.s3.amazonaws.com/91bB7FMHE43HEZkrHEPkMC https://cassyni.com/events/QeYZTxz3ehGexDLuy45epM?videoPreview=1 Misinformation and Disinformation in Hong Kong: Is legislation the answer?nohttps://cassyni.com/events/QeYZTxz3ehGexDLuy45epM?videoPreview=12021-07-07T12:00:00+00:0010998.88Hong Kong Baptist UniversityMisinformation and disinformation is all around us, and comes in many forms. It can be deliberate lies, hoaxes and click bait. You’ve all seen it. You may have even passed it around. But as this deluge of disinformation becomes a tsunami—creating real societal problems and stoking divisions—how do we combat it? Should social media companies be responsible for policing what flows across their platforms? Should journalists take on the added job of fact-checking what flows across the internet? Should consumers become more literate at weeding out bogus news? Or should government pass laws to regulate so-called “fake news”?https://cassyni-user-files-prod.s3.amazonaws.com/91bB7FMHE43HEZkrHEPkMC https://cassyni.com/slides/outline/EmzpFjmqux6EJANkhr1FNu https://cassyni.com/events/EmzpFjmqux6EJANkhr1FNu/abstract https://cassyni-user-files-prod.s3.amazonaws.com/E8gCA3foyRfCEtVWRDRjga https://cassyni.com/events/EmzpFjmqux6EJANkhr1FNu?videoPreview=1 Arts & Sustainable Fashion Design as a Driver of Innovationnohttps://cassyni.com/events/EmzpFjmqux6EJANkhr1FNu?videoPreview=12021-07-05T12:00:00+00:00870.0Hong Kong Baptist UniversityThis abstract explores sustainable fashion design as a driver of innovation, introducing the 'Visionopia' project founded in 2017. The design research blends human connection, nature, and everyday life, guided by the principle that every item possesses a second life and a new soul. Rooted in Sicilian culture and an emphasis on femininity, the approach incorporates light, wind, and reused materials such as old clothes and recycled plastic. A distinctive methodology involves cutting fabrics into strips to form a grid, with all designs constructed without sewing, relying solely on intricate knotting techniques. Early work included a collaboration with the Children's House La Rosin Bali, transforming plastic bags into designs for exhibition and fundraising. The project has been showcased internationally, including at D Street and K11 Art Gallery in Hong Kong, and is currently featured as the Hong Kong Pavilion at the Countless Cities Biennale in Italy, constructed entirely from recycled fabrics and plastic bags. Educational initiatives, such as online workshops with universities in Macau, Hong Kong, and India, and masterclasses in India and Dubai, have empowered students to create accessories and wearable garments using these non-sewing, sustainable methods. These outcomes demonstrate the potential for creative and culturally integrated sustainable fashion to foster human connection, inspire change, and provide innovative solutions for design and community engagement. Future directions involve exploring the sensory experience in design and sustainability through webinars, aiming to connect diverse fields like fashion and communication to achieve a sustainable and improved quality of life for all.https://cassyni-user-files-prod.s3.amazonaws.com/E8gCA3foyRfCEtVWRDRjga https://cassyni.com/slides/outline/4tcPcd746P81FBLrwvYvYV https://cassyni.com/events/4tcPcd746P81FBLrwvYvYV/abstract https://cassyni-user-files-prod.s3.amazonaws.com/TEs7zps873fu9Li4F9FCnr https://cassyni.com/events/4tcPcd746P81FBLrwvYvYV?videoPreview=1 China in Hollywood, Hollywood in China: A Discussion with Erich Schwartzel and Ying Zhunohttps://cassyni.com/events/4tcPcd746P81FBLrwvYvYV?videoPreview=12022-12-01T12:00:00+00:004185.16Hong Kong Baptist UniversityNo abstracthttps://cassyni-user-files-prod.s3.amazonaws.com/TEs7zps873fu9Li4F9FCnr https://cassyni.com/slides/outline/HEpVmiHB4py9CBA1QtU2NH https://cassyni.com/events/HEpVmiHB4py9CBA1QtU2NH/abstract https://cassyni-user-files-prod.s3.amazonaws.com/7QLr8svPnWbxepz9AnTq9G https://cassyni.com/events/HEpVmiHB4py9CBA1QtU2NH?videoPreview=1 Recording Speech Sounds — Ep.02nohttps://cassyni.com/events/HEpVmiHB4py9CBA1QtU2NH?videoPreview=12021-04-27T12:00:00+00:00222.04Hong Kong Baptist UniversityThis seminar addresses the challenges and practical considerations involved in recording speech sounds, particularly during fieldwork where laboratory conditions are unavailable. It emphasizes the importance of high-quality audio capture for phonetic analysis, noting that common devices such as mobile phones often yield insufficient sound quality. The discussion focuses on three critical components for field recording: microphones, recorders, and stimulus presenters. For microphones, head-mounted designs are recommended over stand-mounted types to maintain a consistent mouth-to-microphone distance, thereby reducing amplitude variability caused by speaker movement. Regarding recorders, professional devices like the Tascam recorder are preferred over laptops due to lower noise interference and greater portability, with features such as battery operation enhancing field usability. For stimulus presentation, electronic devices such as iPads or Kindles are advised instead of printed paper to minimize extraneous noise from handling. These recommendations aim to optimize the reliability and clarity of speech recordings in non-laboratory environments, facilitating more accurate phonetic analysis. Future discussions will provide additional practical tips for effective fieldwork recording.https://cassyni-user-files-prod.s3.amazonaws.com/7QLr8svPnWbxepz9AnTq9G https://cassyni.com/slides/outline/Ki4X18WoG7jdZ7dZxaNf6D https://cassyni.com/events/Ki4X18WoG7jdZ7dZxaNf6D/abstract https://cassyni-user-files-prod.s3.amazonaws.com/GGJBeNi1G2SDVyrwe4hntn https://cassyni.com/events/Ki4X18WoG7jdZ7dZxaNf6D?videoPreview=1 Chinese Wolf Warrior Diplomacy & Reporting Sexual Violence in Greater Chinanohttps://cassyni.com/events/Ki4X18WoG7jdZ7dZxaNf6D?videoPreview=12025-02-21T12:00:00+00:005271.76Hong Kong Baptist UniversityWolf Warrior Diplomacy and China’s Ministry of Foreign Affairs: From Policy to Podium (2024) delves into the transformation of Chinese foreign policy from Mao Zedong to Xi Jinping, exploring how domestic shifts and global power dynamics have shaped the aggressive diplomacy of the Chinese Communist Party (CCP). It reveals how Xi Jinping’s era ushered in a new wave of "Wolf Warrior" diplomats tasked with asserting China's confidence and proactive stance on the global stage. The book provides a nuanced understanding of the evolution of CCP diplomatic language and its reception, particularly in the Global South, through advanced computational analysis of press conferences, speeches, and government statements. This work is essential for scholars of communication, international relations, and Chinese foreign policy. Reporting Sexual Violence and #MeToo in Asia: The View from Hong Kong, Mainland China, and Taiwan (2025) examines how media systems in these three culturally similar but politically distinct societies have shaped public discourse on sexual violence and #MeToo. The book analyzes how journalistic coverage of rape cases and social movements influences cyber activism, cultural narratives, and activist strategies. It highlights the complexities of news production, the constraints of reporting on sexual violence, and the transformative potential of social media as a tool for activism and survivor support. Offering insights into practical strategies for engagement and action, the book provides a roadmap for fostering more empathetic and impactful reporting on sexual violence in diverse contexts.https://cassyni-user-files-prod.s3.amazonaws.com/GGJBeNi1G2SDVyrwe4hntn https://cassyni.com/slides/outline/Y4GdADgvEZaVSnsNvvwPEM https://cassyni.com/events/Y4GdADgvEZaVSnsNvvwPEM/abstract https://cassyni-user-files-prod.s3.amazonaws.com/5xv4vAdn58pMZvCNNWT5Fc https://cassyni.com/events/Y4GdADgvEZaVSnsNvvwPEM?videoPreview=1 T10 Google Colaboratorynohttps://cassyni.com/events/Y4GdADgvEZaVSnsNvvwPEM?videoPreview=12023-08-07T12:00:00+00:00369.68Hong Kong Baptist UniversityThe increasing complexity of data mining tasks, particularly the application of artificial neural networks (ANNs) to classify images and text, necessitates a transition from simpler graphical tools to robust programming environments. This study introduces Google Colaboratory (Colab) as a web-based application designed for executing Jupyter notebooks, which integrate formatted text, images, and executable Python code. Colab leverages powerful Google servers, requiring only a web browser and a Google account for access. The analysis demonstrates Colab's core functionalities, beginning with the structure and utility of Markdown cells for documenting and enriching results. These cells support formatting through HTML and Markdown, allowing for elements such as bold, italic, images, and links. Subsequently, the functionality of code cells is explored, illustrating how Python code is executed, how variables are assigned and stored in memory for subsequent computations across cells (e.g., calculating `seconds_in_a_day` and `seconds_in_a_week`), and how outputs are displayed. The platform's capability for data visualization is also presented, showing the generation and modification of dynamic charts using Python libraries for numerical data. Colab offers a versatile environment for scientific projects, providing a powerful and accessible platform for developing advanced machine learning applications, including the future implementation of ANNs with the TensorFlow library for image and text classification.https://cassyni-user-files-prod.s3.amazonaws.com/5xv4vAdn58pMZvCNNWT5Fc https://cassyni.com/slides/outline/Sd8yeha9QXVR3vd9L1wbEu https://cassyni.com/events/Sd8yeha9QXVR3vd9L1wbEu/abstract https://cassyni-user-files-prod.s3.amazonaws.com/KdPYfUTq17od9b49KinBbk https://cassyni.com/events/Sd8yeha9QXVR3vd9L1wbEu?videoPreview=1 MIIND and HEART: Measuring and Designing for Thicker Qualities of User Experiencenohttps://cassyni.com/events/Sd8yeha9QXVR3vd9L1wbEu?videoPreview=12023-05-25T12:00:00+00:001295.64Hong Kong Baptist UniversityUser experience of digital platforms and technologies tends to be quite ‘thin’, characterized by low-quality engagements such as addictive tendencies or browsing on autopilot. This paper takes an interdisciplinary approach to identifying the cognitive and active dimensions of ‘thick’ user experience, introducing a new design and UX framework which is centered around the notion of joy. We first discuss existing frameworks for measuring the quality of user experience. We explain how many harmful kinds of engagement either do not impact negatively on usual metrics, or even result in higher scores according to these assessments. We then draw on recent work in positive psychology, which has seen a move from happiness and ‘thin’ conceptions of pleasure to ‘thicker’ notions such as joy. We use these resources to develop the MIIND framework as a supplement to usual approaches, with the dimensions of Motivation, Integrity, Intensity, Normative Content, and Dependent. We also provide examples of survey questions for measuring and evaluating these dimensions. We end by suggesting new research directions, including exploring how MIIND metrics correlate with increases in adoption, retention, task success, and financial profitability.https://cassyni-user-files-prod.s3.amazonaws.com/KdPYfUTq17od9b49KinBbk https://cassyni.com/slides/outline/T7nahPDfqz3U3hA2vTEPWD https://cassyni.com/events/T7nahPDfqz3U3hA2vTEPWD/abstract https://cassyni-user-files-prod.s3.amazonaws.com/PNsdgaCFhQquazF1dirFDx https://cassyni.com/events/T7nahPDfqz3U3hA2vTEPWD?videoPreview=1 Alchemy and Tantra: Intersections of South Asian Health and Ritualnohttps://cassyni.com/events/T7nahPDfqz3U3hA2vTEPWD?videoPreview=12023-02-22T12:00:00+00:002857.48Hong Kong Baptist UniversityIn this talk, Dr. Sauthoff will discuss the relationship between Śaiva Tantric religion and South Asian alchemical practices called rasaśāstra. She will examine the alchemical corpus for the uses of mantras, prayers, and mythology that have their roots in tantric traditions. She will then discuss the introduction of mercury into South Asian medical practices and how this ingredient parallels to the embodied tantric understanding of male and female sexual fluids. Finally, she will discuss the perfected body (dehasiddhi) to explore how alchemical notions differ from those found in tantra and yoga.https://cassyni-user-files-prod.s3.amazonaws.com/PNsdgaCFhQquazF1dirFDx https://cassyni.com/slides/outline/5subhzQ6yJE9uwAs3u2FMP https://cassyni.com/events/5subhzQ6yJE9uwAs3u2FMP/abstract https://cassyni-user-files-prod.s3.amazonaws.com/3JbURSMCNyE4dkN4uK7iY6 https://cassyni.com/events/5subhzQ6yJE9uwAs3u2FMP?videoPreview=1 Controversies on the Morality and Effectiveness of Judicial Torture in late Ming Chinanohttps://cassyni.com/events/5subhzQ6yJE9uwAs3u2FMP?videoPreview=12021-11-19T12:00:00+00:005271.72Hong Kong Baptist UniversityThis seminar explores the controversial views of late Ming China (1550-1644) to judicial torture from two opposite but interactive directions. While considered an effective, if not indispensable, measure to finding facts of crimes before the age of scientific investigation and DNA testing, in their judicial casebooks the late Ming prefectural judges often complained against the wrongful application of judicial torture of their subordinates at the lower levels. They argued that in the hands of inexperienced and careless magistrates and underlings, forcing confession by violence indeed corrupted the judiciary other than brought justice to light. On the other hand, in many contemporaneous popular novels and novellas, such as Feng Menglong’s 馮夢龍 (1574-1646) celebrated series of vernacular stories, the Sanyan 三言, judicial torture, however, is not blamed as a source of injustice in the same way of the judges. On the contrary, it is lavishly employed by good judges in the stories who discovered hidden details of crimes and therefore effectively eliminated evil. By comparing reasons of different strata of society in our sources on both criticizing and supporting the application of torture at court, how the late Ming people found the principles to manage this violent judicial apparatus is discussed in the conclusion.https://cassyni-user-files-prod.s3.amazonaws.com/3JbURSMCNyE4dkN4uK7iY6 https://cassyni.com/slides/outline/2RNNPCsRu6MWtEsJQEeHpZ https://cassyni.com/events/2RNNPCsRu6MWtEsJQEeHpZ/abstract https://cassyni-user-files-prod.s3.amazonaws.com/2kvd2m3xSYdXsvX3GjVrDc https://cassyni.com/events/2RNNPCsRu6MWtEsJQEeHpZ?videoPreview=1 Hong Kong Is Not Over, Why and How?nohttps://cassyni.com/events/2RNNPCsRu6MWtEsJQEeHpZ?videoPreview=12024-10-19T12:00:00+00:007426.76Hong Kong Baptist UniversityInvestment and consumption in Hong Kong’s economy have not fully recovered as expected post-COVID. Some blame it on the city’s political situation as well as the economic troubles on the mainland. Pessimists warn that Hong Kong’s long-cherished East-West intermediary role is over amid the changing geopolitics. Just rebutting such doomsday talk is not enough. At this critical juncture, Hong Kong needs more actions in re-strategizing and repositioning to secure an economic reset and restore its international impact.https://cassyni-user-files-prod.s3.amazonaws.com/2kvd2m3xSYdXsvX3GjVrDc https://cassyni.com/slides/outline/GmNfe6nkwtEy7c9MUmH3pq https://cassyni.com/events/GmNfe6nkwtEy7c9MUmH3pq/abstract https://cassyni-user-files-prod.s3.amazonaws.com/BAd7jh8Xzr6FkSQcrEP6DL https://cassyni.com/events/GmNfe6nkwtEy7c9MUmH3pq?videoPreview=1 Circuit Mechanisms of Diseasenohttps://cassyni.com/events/GmNfe6nkwtEy7c9MUmH3pq?videoPreview=12021-07-27T04:00:00+00:003288.32The Auckland Bioengineering InstituteMy research focusses on how brain cell activity controls behaviour and what happens when this goes awry in disease. We utilise cellular recording in live mice (‘in vivo’) using a range of different imaging technologies. We have custom-built two specialised microscopes for this purpose – a two-photon microscope that allows high resolution deep imaging, and a ‘mesoscope’ with a wide field of view that is capable of imaging the entire mouse cortex. In addition, we use minaturised microscopes ('miniscopes') to record cellular activity in freely moving animals. These techniques allow us to track activity in the brain in real-time and relate the activity to behaviour or sensory input. Our current research is investigating on Autism Spectrum Disorder, Alzheimer’s disease, and Spinal Cord Injury. https://cassyni-user-files-prod.s3.amazonaws.com/BAd7jh8Xzr6FkSQcrEP6DL https://cassyni.com/slides/outline/HG5Wv3U4C4eqpPkfvzBtpm https://cassyni.com/events/HG5Wv3U4C4eqpPkfvzBtpm/abstract https://cassyni-user-files-prod.s3.amazonaws.com/H8sBTGQEeWjGw1tufqGt4n https://cassyni.com/events/HG5Wv3U4C4eqpPkfvzBtpm?videoPreview=1 Time-domain investigation of wave propagation in effective metamaterial modelsnohttps://cassyni.com/events/HG5Wv3U4C4eqpPkfvzBtpm?videoPreview=12021-07-06T14:00:00+00:005000.6MetaMATWave propagation in microstructured media is often expressed in the frequency domain. This is particularly the case for resonant media, where resonance frequencies are explicitly involved in the PDE (e.g. Helmholtz resonators, high contrast media, etc.). However, it is possible to describe these phenomena based on the auxiliary field formalism. It then becomes possible to use the powerful mathematical and numerical tools specific to hyperbolic systems. The temporal approach allows to study the time of the establishment of periodic phenomena with a single simulation, and is particularly useful when the studied system presents nonlinearities. We will illustrate the subject by reviewing different cases of interest for the “metamaterials” community: 1. High contrast volume homogenization (coll: Cédric Bellis) 2. Resonant outer cloak (coll: Sébastien Guenneau and Cédric Bellis) 3. Resonant metasurfaces (Marie Touboul’s PhD thesis, coll: Cédric Bellis, Agnès Maurel, Kim Pham and Jean-Jacques Marigo) 4. Dynamics of solids with nonlinear cracks (coll. Raphaël Assier, Cédric Bellis, Marie Touboul)https://cassyni-user-files-prod.s3.amazonaws.com/H8sBTGQEeWjGw1tufqGt4n https://cassyni.com/slides/outline/KjKY9ThgPMRLBLEEUg6XYh https://cassyni.com/events/KjKY9ThgPMRLBLEEUg6XYh/abstract https://cassyni-user-files-prod.s3.amazonaws.com/KjGbwrYjxAdniChFLuUeRc https://cassyni.com/events/KjKY9ThgPMRLBLEEUg6XYh?videoPreview=1 Towards the engineering design of metamaterials’ structures through micromorphic enriched continuum modelingnohttps://cassyni.com/events/KjKY9ThgPMRLBLEEUg6XYh?videoPreview=12021-02-16T14:00:00+00:004857.96MetaMATIn this talk, I will show how enriched continuum models of the micromorphic type can be used to describe the dynamical behavior of anisotropic mechanical metamaterials. I will show to which extent one of the the proposed models, that I contributed to pioneer, is able to capture all the main microscopic and macroscopic characteristics of the targeted metamaterials, namely, stiffness, anisotropy, dispersion and band-gaps. The simple structure of our material model, which simultaneously lives on a micro-, a meso- and a macroscopic scale, requires only the identification of a limited number of frequency-independent parameters thus allowing the introduction of pertinent boundary conditions to be imposed at metamaterials’ boundaries when the model is framed in the context of Variational Principles. I will show how this model can be applied to the study of the scattering properties of finite-size metamaterials’ structures thus opening new perspectives for metastructural engineering design.https://cassyni-user-files-prod.s3.amazonaws.com/KjGbwrYjxAdniChFLuUeRc https://cassyni.com/slides/outline/5QVPh1RaFiS2ign1mtd9df https://cassyni.com/events/5QVPh1RaFiS2ign1mtd9df/abstract https://cassyni-user-files-prod.s3.amazonaws.com/553z7inUvsCSFMd6X5FPEe https://cassyni.com/events/5QVPh1RaFiS2ign1mtd9df?videoPreview=1 Flows of vector fields: classical and modernnohttps://cassyni.com/events/5QVPh1RaFiS2ign1mtd9df?videoPreview=12021-04-29T15:00:00+00:003776.0Partial Differential Equations and ApplicationsConsider a (possibly time-dependent) vector field $v$ on the Euclidean space. The classical Cauchy-Lipschitz (also named Picard-Lindelöf) Theorem states that, if the vector field $v$ is Lipschitz in space, for every initial datum $x$ there is a unique trajectory $\gamma$ starting at $x$ at time $0$ and solving the ODE $\dot{\gamma} (t) = v (t, \gamma (t))$. The theorem looses its validity as soon as $v$ is slightly less regular. However, if we bundle all trajectories into a global map allowing $x$ to vary, a celebrated theory put forward by DiPerna and Lions in the 80es show that there is a unique such flow under very reasonable conditions and for much less regular vector fields. A long-standing open question is whether this theory is the byproduct of a stronger classical result which ensures the uniqueness of trajectories for almost every initial datum. I will give a complete answer to the latter question and draw connections with partial differential equations, harmonic analysis, probability theory and Gromov's $h$-principle.https://cassyni-user-files-prod.s3.amazonaws.com/553z7inUvsCSFMd6X5FPEe https://cassyni.com/slides/outline/Y5XeJYsoMoGC51U3T2fFgq https://cassyni.com/events/Y5XeJYsoMoGC51U3T2fFgq/abstract https://cassyni-user-files-prod.s3.amazonaws.com/EYNtcni58n3zo9gVA6KrRC https://cassyni.com/events/Y5XeJYsoMoGC51U3T2fFgq?videoPreview=1 Localisation of light in ordered time dependent systemsnohttps://cassyni.com/events/Y5XeJYsoMoGC51U3T2fFgq?videoPreview=12020-09-15T14:00:00+00:004843.44MetaMATElectromagnetic waves in periodically ordered materials are delocalised into Bloch states, just like electrons in ordered solids. Recently interest has grown in systems ordered in both space and time the simplest example of which might be a permittivity with a 1D grating, $$\varepsilon(x,t)=\varepsilon_1[1+2\alpha\mathrm{cos}(gx-\Omega t)]$$ We stress that this is not a moving medium but a modulation of the medium’s properties phased in time. Hence the velocity of propagation, cg = W/g can take any value -∞< cg<+∞ and is not constrained by relativity. Here too light can propagate in extended Bloch states but there is a range of values [1], $$1/\sqrt{1+2\alpha} \lt \sqrt{\varepsilon_1}c_g / c_0 \lt 1/\sqrt{1-2\alpha}$$ for which the Bloch picture fails. In this so called luminal region any incident radiation will be localised in a series of wells defined by the grating and travelling at the velocity of the grating. We present analytical solutions to this model and in particular explore the localised/delocalised transition which has an exponent of 1/2. Light incident on a grating with cgin the luminal range is compressed and amplified by a novel mechanism into a series of ever more localised pulses which emerge from the far side of the grating as shown in the figure below. For values of cg outside the luminal region a plane electromagnetic wave enters the grating as a linear combination of Bloch waves which oscillate in amplitude as they propagate. Approaching the critical velocity the oscillation period and amplitude diverge. The same exponent controls the diverging period as controls the exponential growth inside the luminal regime: a familiar result from localisation in disordered systems.https://cassyni-user-files-prod.s3.amazonaws.com/EYNtcni58n3zo9gVA6KrRC https://cassyni.com/slides/outline/4RCBbe8XNoKt3vx1fv9ppm https://cassyni.com/events/4RCBbe8XNoKt3vx1fv9ppm/abstract https://cassyni-user-files-prod.s3.amazonaws.com/CKJf8jNaQ6XTz1LhDEdfDY https://cassyni.com/events/4RCBbe8XNoKt3vx1fv9ppm?videoPreview=1 Vocabulary related episodes (VREs) in EFL listening lessons: How, why, when and who benefits?nohttps://cassyni.com/events/4RCBbe8XNoKt3vx1fv9ppm?videoPreview=12021-08-06T16:00:00+00:002780.24Linguistics and Applied Language StudiesThis presentation reports on results from Judy’s PhD research into the teaching of L2 listening in EFL classes taught by two teachers at a Chinese university. The research focused on the relationship between vocabulary and listening. Observation data was collected from thirteen lessons taught by the two teachers (six and seven lessons respectively). Data was also collected from interviews with the teachers and their students who also sat pre-and post-lesson vocabulary tests to investigate vocabulary learning gains from these classes. This talk will report findings on the nature of vocabulary related episodes (VREs) initiated by the teachers and on the relationship between VREs and vocabulary learning. These findings include comparisons of the ways each teacher dealt with vocabulary and of their different views of the importance of vocabulary in listening, as well as how these behaviours and views influenced the perceptions of learners as to the value of vocabulary teaching.https://cassyni-user-files-prod.s3.amazonaws.com/CKJf8jNaQ6XTz1LhDEdfDY https://cassyni.com/slides/outline/NhEnYC6iRTfh2xTXja1rj7 https://cassyni.com/events/NhEnYC6iRTfh2xTXja1rj7/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Kv8CfTCQsdYXzhL731QpYe https://cassyni.com/events/NhEnYC6iRTfh2xTXja1rj7?videoPreview=1 Metasurfaces and metabuildings in megacities: Cloaking of body and surface seismic wavesnohttps://cassyni.com/events/NhEnYC6iRTfh2xTXja1rj7?videoPreview=12022-02-15T14:00:00+00:004312.6MetaMATSeismic waves propagate in complex heterogeneous geological structures and may be strongly amplified when reaching the free surface. Due to strong velocity contrasts, seismic waves are particularly amplified in alluvial basins thus leading to extensive surface waves generation. Such surface waves may interact with buildings at the local scale (soil-structure interaction/SSI) as well as the scale of an entire city (site-city interaction/SCI). In this talk, we emphasize on the quantification of such surface waves through the Normalized-Inner Product allowing an efficient time-frequency extraction. Various modeling strategies are then discussed to analyze wave-structures interaction in alluvial basins at various scales: 1DT-3C approach, impedance functions, macroelement formulations, homogenization methods (either for foundations or structures), fast-Boundary Element Methods, large site-city models for actual urban environments. The main issues are the complexity and the efficacy of these various approaches. The final goal being to answer this crucial question: is site-city interaction beneficial or detrimental?https://cassyni-user-files-prod.s3.amazonaws.com/Kv8CfTCQsdYXzhL731QpYe https://cassyni.com/slides/outline/Ucxns8qEtETnDchrbhT8F7 https://cassyni.com/events/Ucxns8qEtETnDchrbhT8F7/abstract https://cassyni-user-files-prod.s3.amazonaws.com/5SbRmAq6RCyCuWm8yU5gPQ https://cassyni.com/events/Ucxns8qEtETnDchrbhT8F7?videoPreview=1 Stability of sharp Fourier restrictionnohttps://cassyni.com/events/Ucxns8qEtETnDchrbhT8F7?videoPreview=12021-10-07T13:00:00+00:003885.4Partial Differential Equations and ApplicationsThe classical paper of R. Strichartz [Duke Math. J., 1977] has been very influential for the study of partial differential equations. This is the birth of what became known as 'Strichartz estimates', which can be equivalently seen as Fourier (adjoint) restriction inequalities over certain quadratic surfaces: paraboloids, cones, spheres and hyperboloids. In the first part of this talk I will briefly give an overview of what is currently known in the theme of `sharp Fourier restriction' theory, that is, the search for extremizers of these inequalities. For instance, in the case of the sphere, it is conjectured that the constant functions should be the extremizers for the $L^2 \to L^q$ adjoint Fourier restriction, but this has only been proved in some cases. I will then discuss how some of these extremizers remain stable under perturbations of the underlying Lebesgue measure, by exploring the structure of the associated Helmholtz equation. This is based on a recent joint work with Negro and Oliveira e Silva (https://arxiv.org/abs/2108.03412).https://cassyni-user-files-prod.s3.amazonaws.com/5SbRmAq6RCyCuWm8yU5gPQ https://cassyni.com/slides/outline/QB8MSz1Ww7UXkxx4h3gZ6d https://cassyni.com/events/QB8MSz1Ww7UXkxx4h3gZ6d/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Kz5BSakhQFXwU1koU93CVC https://cassyni.com/events/QB8MSz1Ww7UXkxx4h3gZ6d?videoPreview=1 SmN: A dopable ferromagnetic semiconductor with zero net momentnohttps://cassyni.com/events/QB8MSz1Ww7UXkxx4h3gZ6d?videoPreview=12022-01-18T18:00:00+00:004016.12School of Chemical and Physical SciencesThe magnetic properties of the rare earth nitride series are determined largely by the occupation of the 4$f$ electron shell. However, in a select few members the localised 4$f$ states hybridise with the extended 5$d$ states at the Fermi energy and thus directly influence electrical transport. Here we discuss a combined experimental and computational study of nitrogen vacancy doped SmN. We show that the material crosses an insulator-to-metal transition as samples are increasingly doped with nitrogen vacancies (Figure 1). At low doping levels the transport can be understood as variable range hopping between defect states, while at high doping levels extended state metallic transport is seen. In the intermediary 'anomalous metallic' region where transport is in a mixed 4$f$-5$d$ band there are indications of more exotic ground states, such as unconventional superconductivity, which furthermore may coexist with ferromagnetic order.https://cassyni-user-files-prod.s3.amazonaws.com/Kz5BSakhQFXwU1koU93CVC https://cassyni.com/slides/outline/FHTUcgN52sWMaCn3HTPWmb https://cassyni.com/events/FHTUcgN52sWMaCn3HTPWmb/abstract https://cassyni-user-files-prod.s3.amazonaws.com/6JfzjRuJ2Waj73d6i26Rst https://cassyni.com/events/FHTUcgN52sWMaCn3HTPWmb?videoPreview=1 A game theoretical approach for a nonlinear system driven by elliptic operatorsnohttps://cassyni.com/events/FHTUcgN52sWMaCn3HTPWmb?videoPreview=12020-08-31T15:00:00+00:003413.04Partial Differential Equations and ApplicationsThis talk is based on the interplay between partial differential equations and probability. We find approximations using game theory to viscosity solutions to an elliptic system governed by two different operators(the Laplacian and the infinity Laplacian). We analyze a game that combines Tug - of -War with Random Walks in two different boards with a positive probability of jumping from one board to the other and we prove that the value functions for this game converge uniformly to a viscosity solution of an elliptic system as the step size goes to zero. In addition, we show uniqueness for the elliptic system using pure PDE techniques. Joint work with A.Miranda(Buenos Aires).https://cassyni-user-files-prod.s3.amazonaws.com/6JfzjRuJ2Waj73d6i26Rst https://cassyni.com/slides/outline/NCZZNswJaeBsDVU1wTttYu https://cassyni.com/events/NCZZNswJaeBsDVU1wTttYu/abstract https://cassyni-user-files-prod.s3.amazonaws.com/PYeiRfxg6AcqKZGnPPv4PG https://cassyni.com/events/NCZZNswJaeBsDVU1wTttYu?videoPreview=1 High-Order Implicit Large-eddy Simulations of Flow around a Projectile using PyFRnohttps://cassyni.com/events/NCZZNswJaeBsDVU1wTttYu?videoPreview=12021-11-10T15:00:00+00:002460.2PyFRIn this talk I will demonstrate how PyFR can be applied to simulate three challenging unsteady flow around projectile. The first problem is subsonic flow after projectile base, which yields a significant portion of drag of projectile. The numerical results are compared with the experiments in terms of aerodynamic drag, pressure distribution on base and separation bubble size. The second problem is to simulate so-called 'phantom-yaw', asymmetric shedding of vortices at high angle of attack. The distinct instability modes, which were witnessed in the experiments, are reproduced in simulations and flow structures of each mode are compared. The last problem is laminar separation bubble on Low-Reynolds Number airfoil. The numerical results are compared with the experiments in terms of aerodynamic forces and transition of separation bubbles along the angle of attack is witnessed. https://cassyni-user-files-prod.s3.amazonaws.com/PYeiRfxg6AcqKZGnPPv4PG https://cassyni.com/slides/outline/2SdPXY4K2L3DWTTxvLNAH3 https://cassyni.com/events/2SdPXY4K2L3DWTTxvLNAH3/abstract https://cassyni-user-files-prod.s3.amazonaws.com/LKBGUu4t7TLYXt8DWUQeiz https://cassyni.com/events/2SdPXY4K2L3DWTTxvLNAH3?videoPreview=1 Starshade Technology Development: Deployment Accuracy and Thermoelastic Stability of Key Structuresnohttps://cassyni.com/events/2SdPXY4K2L3DWTTxvLNAH3?videoPreview=12021-11-17T18:00:00+00:003616.48Department of AeronauticsA starshade is a conceptual spacecraft that blocks starlight to enable space telescopes to directly image exoplanets. Starshade concepts must be stowed within rocket fairings for launch and then deployed in space. The in-plane deployment accuracy and the in-space thermoelastic shape stability of these structures must be on the order of hundreds of micrometers for sufficient starlight suppression to enable the detection and study of Earth-like exoplanets around nearby Sun-like stars. We describe tests conducted to demonstrate deployment repeatability and thermoelastic shape stability of key structural subsystems of the “furled” starshade architecture. This work is conducted alongside a number of activities to mature starshade technology; these activities will also be briefly discussed.https://cassyni-user-files-prod.s3.amazonaws.com/LKBGUu4t7TLYXt8DWUQeiz https://cassyni.com/slides/outline/2wJcgrDis9X3KvTUiSV8TF https://cassyni.com/events/2wJcgrDis9X3KvTUiSV8TF/abstract https://cassyni-user-files-prod.s3.amazonaws.com/XZa71u3sJLj5NgzzTeu6ir https://cassyni.com/events/2wJcgrDis9X3KvTUiSV8TF?videoPreview=1 Quantum Meta-Photonicsnohttps://cassyni.com/events/2wJcgrDis9X3KvTUiSV8TF?videoPreview=12022-05-31T13:00:00+00:003666.6MetaMATWe discuss how various ideas and notions from the field of metamaterials can benefit the emerging area of quantum science and technology. Specifically, we show that the enhancement and speedup enabled by plasmonic metamaterials open up a means to outpace dephasing and thus make quantum systems immune to decoherence. We also discuss new opportunities for SiN quantum photonic circuitry enabled by our recent discovery of single-photon sources in this technologically important material platform. Our findings spark further studies of quantum emitters toward deeper understanding of their nature, deterministic formation, and scalable integration with on-chip quantum photonic circuitry. We also demonstrate how hybrid quantum sensors with record-high sensitivity can be developed, by employing spin qubits controlled by light and coupled via magnons. The important role of machine-learning designs for quantum photonic circuitry will be also discussed. https://cassyni-user-files-prod.s3.amazonaws.com/XZa71u3sJLj5NgzzTeu6ir https://cassyni.com/events/6PjMZ7grKugpSd9pB6PiWh/seminar/qa https://cassyni.com/slides/outline/6PjMZ7grKugpSd9pB6PiWh https://cassyni.com/events/6PjMZ7grKugpSd9pB6PiWh/abstract https://cassyni-user-files-prod.s3.amazonaws.com/BHnWzs3R7DEHAgjPycgDrE https://cassyni.com/events/6PjMZ7grKugpSd9pB6PiWh?videoPreview=1 Human Powered Flight, the challenges and progressnohttps://cassyni.com/events/6PjMZ7grKugpSd9pB6PiWh?videoPreview=12021-07-06T04:00:00+00:003854.08The Auckland Bioengineering InstituteWhat does it take to fly an HPA: the history of the sport and where you can do it: the engineering challenge and the human factors to overcome. What it is like and how much energy it takes to fly, the previous research and the best approaches and common materials to build an HPA. What can go wrong in flights, and how much control you have and the aircrafts present limits. The events in Human Powered Flying, and the 4 outstanding prizes in the sport yet to be won. ( total Prizes in the UK add up to $270,000). What does success result in and the real world application of this technology in High Altitude Autonomous aircraft (eg Airbus Zephyr).)https://cassyni-user-files-prod.s3.amazonaws.com/BHnWzs3R7DEHAgjPycgDrE https://cassyni.com/slides/outline/5uAcrKaz6XurY9mXZzk7os https://cassyni.com/events/5uAcrKaz6XurY9mXZzk7os/abstract https://cassyni-user-files-prod.s3.amazonaws.com/57gTvKTMczJgraSiHamooC https://cassyni.com/events/5uAcrKaz6XurY9mXZzk7os?videoPreview=1 Mathematical modelling of Covid-19 dynamics in New Zealandnohttps://cassyni.com/events/5uAcrKaz6XurY9mXZzk7os?videoPreview=12021-11-23T01:00:00+00:003490.64The Auckland Bioengineering InstituteMathematical models can be useful to understand the dynamics of the epidemic and how control measures may affect potential future trajectories. I will describe some models of Covid-19 dynamics in New Zealand, how they have been calibrated to data, and some of the insights they can provide. Michael Plank is a Professor in the School of Mathematics and Statistics at the University of Canterbury in New Zealand and Principal Investigator at Te Pūnaha Matatini, New Zealand's Centre of Research Excellence in Complex Systems and Data Analytics. He obtained his BSc(Hons) in Mathematics from the University of Bristol in 2000 and his PhD in Applied Mathematics from the University of Leeds in 2003. He started at the University of Canterbury as a postdoctoral research fellow in 2004 and as a permanent academic staff member in 2006. Professor Plank is an expert in mathematical modelling of complex biological and social systems at multiple scales, from intracellular signalling and collective cell behaviour, through to large ecosystem dynamics. His research is application-driven and focuses on mechanistic mathematical and stochastic models that capture emergent behaviour and offer qualitative insight into underlying mechanisms. His areas of expertise include ecological and social networks, population dynamics, epidemiological models, size-structured marine ecosystems, collective cell behaviour, and intracellular dynamics. His research draws on numerous fields in applied mathematics including stochastic processes, integro and partial differential equations, dynamical systems, spatial moment dynamics, statistical modelling, and parameter inference. His research has funded been funded by industry and government, by Te Pūnaha Matatini and by grants from the Marsden Fund and Australian Research Council. Professor Plank has served in various governance and editorial roles. He is currently President of the NZ Branch of Australia and New Zealand Industrial and Applied Mathematics (ANZIAM) and a member of the University of Canterbury's Academic Board. He is an Editorial Board member for the ANZIAM Journal. He has served as a panellist for the Marsden Fund and Performance-Based Research Fund and represents ANZIAM at the International Council for Industrial and Applied Mathematics. https://cassyni-user-files-prod.s3.amazonaws.com/57gTvKTMczJgraSiHamooC https://cassyni.com/slides/outline/X6HgSScXHc1QLmWQ5zHMad https://cassyni.com/events/X6HgSScXHc1QLmWQ5zHMad/abstract https://cassyni-user-files-prod.s3.amazonaws.com/75wTJkuT4osf1iMzdYaRG2 https://cassyni.com/events/X6HgSScXHc1QLmWQ5zHMad?videoPreview=1 Applications of K-Theory in Materials Sciencenohttps://cassyni.com/events/X6HgSScXHc1QLmWQ5zHMad?videoPreview=12022-07-26T13:00:00+00:007783.52MetaMATHeisenberg formulation of quantum mechanics puts a focus on the physical observables which are organized as operator algebras. This approach and point of view has recently penetrated into metamaterials science. The goal of this talk is to explain this statement and to demonstrate the power of the theoretical tools that comes from the field of operator algebras, such as K-theory. As we shall see, the dynamical matrices of various classes of metamaterials generate specific topological algebras that can be computed explicitly. This will be exemplified using the class of periodic metamaterials, then that of quasi-periodic metamaterials and, lastly, that of metamaterials symmetric to a full space group. The talk will then introduce the notions of complete topological invariants and of stable homotopy. The equivalence class of a band projection with respect to the stable homotopy defines the complete topological invariant that can be associated with that projection and these equivalence classes lead to the K-group of the algebra of dynamical matrices. The last part of the talk exemplifies the K-groups for classes of metamaterials mentioned above. As we shall see, once the K-groups and their generators are known, one can produce a complete list of topological models which supply all topological phases supported by a particular class of metamaterials. Additional ways of using the K-groups will be presented.https://cassyni-user-files-prod.s3.amazonaws.com/75wTJkuT4osf1iMzdYaRG2 https://cassyni.com/events/4usQkxHwDcohsPwXU2Gnzy/seminar/qa https://cassyni.com/slides/outline/4usQkxHwDcohsPwXU2Gnzy https://cassyni.com/events/4usQkxHwDcohsPwXU2Gnzy/abstract https://cassyni-user-files-prod.s3.amazonaws.com/B6a58fob9YceQ7YttY1Fxa https://cassyni.com/events/4usQkxHwDcohsPwXU2Gnzy?videoPreview=1 The Quest Towards Robust, Adaptive, and Smart Compressible Solversnohttps://cassyni.com/events/4usQkxHwDcohsPwXU2Gnzy?videoPreview=12022-02-21T15:00:00+00:004124.72Journal of Computational PhysicsTogether with the algorithm suitability to exploit current petascale and next-generation exascale supercomputers, robust, accurate, and structure-preserving discretizations are necessary for developing predictive computational tools. In this seminar, we will show how to leverage a multidisciplinary platform that integrates numerical analysis, physics, and high-performance computing for the analysis and development of novel numerical methods for ordinary and partial differential equations with provable properties such as nonlinear stability (entropy stability) and conservation, and structure-preserving techniques. These properties are critical for designing reliable, efficient, and self-adaptive solvers for complex geometries – an essential cornerstone for next-generation computational frameworks. Current classes of partial differential equations that we are working on are the compressible Navier–Stokes equations and the Eulerian model for compressible heat-conducting flows. We also use deep learning to complement and speed up the process of solving efficiently large-scale PDE-based problems. In this talk, we will summarize the progress we made in the last few years in the following areas: - Numerical analysis and algorithm development for robust, smart compressible flow solvers. - Development from the ground up of a new scalable hp-adaptive computational fluid dynamics (CFD) framework, a potential prototype of the future compressible solver as chartered by the NASA CFD 2030 vision. I will show applications and impact in the automotive and aerospace industry and in it extension for improving knowledge of flow physics in detonation and aeroacoustics.https://cassyni-user-files-prod.s3.amazonaws.com/B6a58fob9YceQ7YttY1Fxa https://cassyni.com/slides/outline/PBtPaskErvDk2izRL1JezR https://cassyni.com/events/PBtPaskErvDk2izRL1JezR/abstract https://cassyni-user-files-prod.s3.amazonaws.com/CdbALzvJoVKBtSRLsfiACN https://cassyni.com/events/PBtPaskErvDk2izRL1JezR?videoPreview=1 Space Debris: Status of the environment & mitigation measures - Speaker: Francesca Letizia (ESA/ESOC)nohttps://cassyni.com/events/PBtPaskErvDk2izRL1JezR?videoPreview=12022-03-23T16:00:00+00:003361.6Department of AeronauticsEver since the start of the space age in 1957, there has been more space debris in orbit than operational satellites. While in the beginning, the risk posed by space debris was unclear, it has now become a reality for any space operator, with mitigation actions required both in the short and in the long-term. The presentation will discuss the status of the debris environment together with the effectiveness and adoption of such mitigation actions. The presentation will conclude with a quick overview of what sustainability means for space operations with respect to the space debris issue and of which are current efforts related to this topic.https://cassyni-user-files-prod.s3.amazonaws.com/CdbALzvJoVKBtSRLsfiACN https://cassyni.com/slides/outline/YaCsTs3DCck1tUTZF8nDs3 https://cassyni.com/events/YaCsTs3DCck1tUTZF8nDs3/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Ht2xZLvLRB34vyFNxsEetN https://cassyni.com/events/YaCsTs3DCck1tUTZF8nDs3?videoPreview=1 Research Ideas Worth Funding IInohttps://cassyni.com/events/YaCsTs3DCck1tUTZF8nDs3?videoPreview=12022-03-18T02:00:00+00:005956.64Faculty of Business and EconomicsHealth and well-being research features strongly in Taumata Teitei. In this online event, each presenter had four minutes to make a pitch about their research and a proposed research idea. We hope that this triggered further thoughts and conversations on the topics raised and unveil shared research interests that you may want to explore further. This is the Business School Health and Well-Being Research Beacon’s second cross-disciplinary research ideas event for all those interested in connecting and collaborating under the Beacon’s theme. The programme comprises updates on new or planned research projects by leading researchers from the Business School and other faculties. The event was open to presenters and participants from all faculties and large-scale research institutes. **Paola Boarin** and **Alessandro Premier**: Promoting health and well-being in the built environment: perspectives from the building and the urban scales **Lixin Jiang** (Science): _Occupational Health Psychology and Organisational Interventions_ **Linda Tyler** (Arts): _The Faculty of Arts' connection with the ADHB and the use of literature and visual arts in promoting well-being_ **Kerry Gibson** (Science): _Student mental health and wellbeing: Ensuring the future_ **Maartje Abbenhuis** and **Thomas Gregory** (Arts): _Wartime harm: Thinking about regulating the weapons and wounds of war_ **Nickola Overall** (Science): _Family Resilience and Well-being_ **Nancy November** (Arts): _Pedagogical Wellbeing and Pasifika Students’ Success in Tertiary Education: A Transdisciplinary Study_ **Janet Gaffney** and **Jacoba Matapo** (Education and Social Work): _Storying research and wellbeing: Olaga le tagata - Being constituted in collective_ **Angus Campbell** (Creative Arts and Industries): _A Design Approach to Capabilities and Activities for Well-being_ **Ngaire Kerse** (FMHS): _Quality and Equity in Aged Residential Care_ **Paul Rouse** (Business School): _Case mix in community settings_ **Kim Dirks** (Engineering): _Infrastructure for Community Futures Research Centre (ICFRC)_ **Valery Pavlov** (Business School): _Behavioral Enablers of Pods System to Shorten Emergency Department Stay_ **Partha Roop** (Engineering): Algorithmic Wellness **Fernando Beltran** and **Natalie Walker** (Business School and FMHS): _Can an immersive mixed reality retail space be used to measure consumer decision-making in response to public health interventions?_ **Reza Shahamiri** (Engineering): _Deep Learning, Health Delivery, and Assistive Technologies_ **Laszlo Sajtos** and **Nataly Martini** (Business School and FMHS): _Multi-agent shared decision-making in healthcare_https://cassyni-user-files-prod.s3.amazonaws.com/Ht2xZLvLRB34vyFNxsEetN https://cassyni.com/slides/outline/8NSGCNLVhBc7inhiKMUvSh https://cassyni.com/events/8NSGCNLVhBc7inhiKMUvSh/abstract https://cassyni-user-files-prod.s3.amazonaws.com/UVhEH4u4UPB2i8DUttUmsL https://cassyni.com/events/8NSGCNLVhBc7inhiKMUvSh?videoPreview=1 A wave-breaking model for the Depth-Semi-Averaged equations: some preliminary resultsnohttps://cassyni.com/events/8NSGCNLVhBc7inhiKMUvSh?videoPreview=12022-04-12T10:40:00+00:001811.04Water WavesA novel model for the description of the wave breaking process and the subsequent generation and evolution of the vorticity is defined for a particular non-hydrostatic scheme, namely the Depth-SemiAveraged model of Antuono et al. [1]. Such a model is based on the use of mollified differential operators inside the vorticity equation, following an approach which is similar in spirit to that used in the context of the Smoothed Particle Hydrodynamics. The breaking conditions and the expression for the vorticity injection at the free surface are adapted from the work of Veeramony [2] and Veeramony and Svendsen [3] while a proper closure for the turbulent cinematic viscosity is proposed. Some preliminary test cases are shown by using the experimental data from Lucarelli et al. [4] for a spilling breaking event. These suggest that the proposed model is accurate and reliable and that it is suited for the description of the main features of the wave breaking at spatial and time scales typical of the coastal models. The proposed work is developed in collaboration with the Università Politecnica delle Marche (UNIVPM) in the context of the project entitled “FUNdamentals of BREAKing wave-induced boundary dynamics” (FUNBREAK), funded by the Italian Ministry MIUR with grant number 20172B7MY9_003.https://cassyni-user-files-prod.s3.amazonaws.com/UVhEH4u4UPB2i8DUttUmsL https://cassyni.com/slides/outline/AM2gP6vbT1pspVywgKLrsF https://cassyni.com/events/AM2gP6vbT1pspVywgKLrsF/abstract https://cassyni-user-files-prod.s3.amazonaws.com/G2SHMsoT7EMnsz1Yrjyn7p https://cassyni.com/events/AM2gP6vbT1pspVywgKLrsF?videoPreview=1 Measuring Inconsistency in Generalized Propositional Logicnohttps://cassyni.com/events/AM2gP6vbT1pspVywgKLrsF?videoPreview=12021-12-08T11:40:00+00:004428.96Logica UniversalisConsistency is one of the key concepts of logic; logicians have put a great deal of effort into proving the consistency of many logics. Understanding what causes inconsistency is also important; some logicians have developed paraconsistent logics that, unlike classical logics, allow some contradictions without making all formulas provable. Another direction of research studies inconsistency by measuring the amount of inconsistency of sets of formulas. While the initial attempt in 1978 was too ambitious in trying to do this for first-order logic, this research got a substantial boost when an inconsistency measure was proposed for propositional logic in 2002. Since then, researchers in logic and artificial intelligence (AI systems need the capability to deal with inconsistency) have made many interesting proposals and found related issues. Almost all of this work has been done for propositional logic. The purpose of this paper is to extend inconsistency measures to logics that also contain operators, such as modal operators. We use the terminology “generalized propositional logic” for such logics. We show how to extend propositional inconsistency measures to sets of formulas in any such generalized propositional logic. Examples are used to illustrate how various modal operators, including spatial and tense operators, fit into this framework. We also show that the addition of operators leads to a weak type of inconsistency. In all cases, the calculations for several inconsistency measures are given.https://cassyni-user-files-prod.s3.amazonaws.com/G2SHMsoT7EMnsz1Yrjyn7p https://cassyni.com/slides/outline/MDKbWmg2WSw5VFWNaRWzSh https://cassyni.com/events/MDKbWmg2WSw5VFWNaRWzSh/abstract https://cassyni-user-files-prod.s3.amazonaws.com/4TEyosE5P3WMqLmRoFfTLS https://cassyni.com/events/MDKbWmg2WSw5VFWNaRWzSh?videoPreview=1 High Fidelity Lighting and Digital Twins in Mixed Realitynohttps://cassyni.com/events/MDKbWmg2WSw5VFWNaRWzSh?videoPreview=12022-08-31T03:00:00+00:003058.28Computer Graphics GroupI will talk about the importance of lighting in mixed reality rendering. From perceptually-based lighting to machine learning-driven light estimation. I also discuss using these research outcomes to inform and create lighting tools for VFX artists. Finally, I generalize the idea of virtual lighting to future research directions involving the creation of digital twins of physical objects and environments.https://cassyni-user-files-prod.s3.amazonaws.com/4TEyosE5P3WMqLmRoFfTLS https://cassyni.com/slides/outline/LE2PRQNydXpvpVgNUT3fdo https://cassyni.com/events/LE2PRQNydXpvpVgNUT3fdo/abstract https://cassyni-user-files-prod.s3.amazonaws.com/GeZ5FRpZdHHLgQWFX1uwPk https://cassyni.com/events/LE2PRQNydXpvpVgNUT3fdo?videoPreview=1 The Fundamental Theorem of Algebra: Past, Present and Picturesnohttps://cassyni.com/events/LE2PRQNydXpvpVgNUT3fdo?videoPreview=12021-02-27T21:00:00+00:001138.04Mathematical IntelligencerNo abstracthttps://cassyni-user-files-prod.s3.amazonaws.com/GeZ5FRpZdHHLgQWFX1uwPk https://cassyni.com/slides/outline/RfA2vvVkTZvKwuGAV5HZbB https://cassyni.com/events/RfA2vvVkTZvKwuGAV5HZbB/abstract https://cassyni-user-files-prod.s3.amazonaws.com/NLrD5VwVQLvemsRQ7pTQNa https://cassyni.com/events/RfA2vvVkTZvKwuGAV5HZbB?videoPreview=1 Labor and Supply Chain Networks: It’s All About Peoplenohttps://cassyni.com/events/RfA2vvVkTZvKwuGAV5HZbB?videoPreview=12022-08-30T17:00:00+00:003621.68The COVID-19 pandemic, climate change, conflicts and wars have dramatically illustrated the importance of labor in supply chain networks in numerous economic sectors, from agriculture to healthcare. In this talk, I will discuss our research on the inclusion on labor in supply chains both in optimization and game theory frameworks to elucidate the impacts of disruptions of labor in terms of availability as well as productivity on product flows, prices, and the objective functions of organizations, both profit and nonprofit ones. I will also highlight what can be done to ameliorate negative impacts and will discuss the power of setting appropriate wages on supply chain links from production and transportation to storage and the ultimate distribution to points of demand. The use of international migrants to alleviate shortages will be discussed and the impacts of the war on Ukraine on global supply chains. The inclusion of labor in blood service supply chains in healthcare and in humanitarian organization models for disaster preparedness and response will also be highlighted. I will conclude with some of our experiences in influencing policy in the pandemic.https://cassyni-user-files-prod.s3.amazonaws.com/NLrD5VwVQLvemsRQ7pTQNa https://cassyni.com/events/NCyu6Kfbd45mQev3DyyX2D/abstract https://cassyni-user-files-prod.s3.amazonaws.com/KgXiTwBn3mGU6jbS66QguL https://cassyni.com/slides/outline/4RcXK5rpRDDnEnpBzbd84u https://cassyni.com/events/4RcXK5rpRDDnEnpBzbd84u/abstract https://cassyni-user-files-prod.s3.amazonaws.com/PdT7eTJeJ5QaSjo4mELu6e https://cassyni.com/events/4RcXK5rpRDDnEnpBzbd84u?videoPreview=1 Epcoritamab in relapsed/refractory large B-cell lymphoma: 2-year follow-up from the pivotal EPCORE NHL-1 trialnohttps://cassyni.com/events/4RcXK5rpRDDnEnpBzbd84u?videoPreview=12024-10-31T12:00:00+00:00672.48LeukemiaPrimary results (median follow-up, 10.7 months) from the pivotal EPCORE® NHL-1 study in relapsed or refractory (R/R) large B-cell lymphoma (LBCL) demonstrated deep, durable responses with epcoritamab, a CD3xCD20 bispecific antibody, when used as monotherapy. We report long-term efficacy and safety results in patients with LBCL (*N* = 157; 25.1-month median follow-up). As of April 21, 2023, overall response rate was 63.1% and complete response (CR) rate was 40.1%. Estimated 24-month progression-free survival (PFS) and overall survival (OS) rates were 27.8% and 44.6%, respectively. An estimated 64.2% of complete responders remained in CR at 24 months. Estimated 24-month PFS and OS rates among complete responders were 65.1% and 78.2%, respectively. Of 119 minimal residual disease (MRD)–evaluable patients, 45.4% had MRD negativity, which correlated with longer PFS and OS. CR rates were generally consistent across predefined subgroups: 36% prior chimeric antigen receptor (CAR) T-cell therapy, 32% primary refractory disease, and 37% International Prognostic Index ≥3. The most common treatment-emergent adverse events were cytokine release syndrome (51.0%), pyrexia (24.8%), fatigue (24.2%), and neutropenia (23.6%). These results underscore the long-term benefit of epcoritamab for treating R/R LBCL with deep responses across subgroups, including patients with hard-to-treat disease and expected poor prognosis. https://cassyni-user-files-prod.s3.amazonaws.com/PdT7eTJeJ5QaSjo4mELu6e https://cassyni.com/events/8Nrbup4njbW1ux9jbsZYv1/seminar/qa https://cassyni.com/slides/outline/8Nrbup4njbW1ux9jbsZYv1 https://cassyni.com/events/8Nrbup4njbW1ux9jbsZYv1/abstract https://cassyni-user-files-prod.s3.amazonaws.com/H2wMWqLsMJEQv13u5QykJA https://cassyni.com/events/8Nrbup4njbW1ux9jbsZYv1?videoPreview=1 Conflicts in Qualitative Research: Antagonisms between Ethics and Sciencenohttps://cassyni.com/events/8Nrbup4njbW1ux9jbsZYv1?videoPreview=12025-01-31T17:00:00+00:003597.2International Journal of Qualitative MethodsThis Cassyni seminar engages with the intricate dynamics between qualitative research and the ethical oversight processes embedded within academic institutions. Drawing from a Special Collection on this topic, the seminar critically examines the intersection of knowledge production through in-depth qualitative inquiry and the institutional demands of ethics review boards. Qualitative research, by its very nature, seeks to capture the complexity and nuance of human experiences. However, this methodological depth often encounters ethical and procedural challenges, particularly when institutional review board (IRB) processes impose rigid frameworks that may not align with the fluid and emergent characteristics of qualitative methodologies. These tensions raise critical questions about the balance between advancing scholarly inquiry and ensuring ethical compliance. This seminar invites researchers, ethicists, and institutional representatives to engage in an interdisciplinary dialogue that explores the synergies and conflicts between the epistemological goals of qualitative research and the operational demands of ethical oversight. Topics for discussion include power dynamics in researcher-participant relationships, conflicts between IRB mandates and research objectives, stakeholder involvement, privacy and confidentiality considerations, and the challenges of navigating institutional review processes. In addition to these thematic discussions, the seminar aims to foster a critical exchange with participants on the future directions of academic publishing in this area. Together, we will explore how publications can best address the methodological and ethical complexities of qualitative research while promoting scholarly rigor and relevance. The seminar aspires to: 1. Critically analyze the ethical dimensions of qualitative research methodologies. 2. Explore frameworks to reconcile methodological flexibility with institutional ethical standards. 3. Foster scholarly discourse on best practices for navigating ethical review in qualitative research. 4. Engage participants in shaping the trajectory of academic publishing to better reflect and support the evolving demands of qualitative inquiry. Through this engagement, participants will contribute to the development of innovative approaches to harmonize rigorous ethical oversight with the intellectual imperatives of qualitative inquiry, advancing both methodological and institutional practices in contemporary research landscapes.https://cassyni-user-files-prod.s3.amazonaws.com/H2wMWqLsMJEQv13u5QykJA https://cassyni.com/slides/outline/RAu9V44dfALQKbifyVFDtH https://cassyni.com/events/RAu9V44dfALQKbifyVFDtH/abstract https://cassyni-user-files-prod.s3.amazonaws.com/UncKQL1RqD1T7zjCa8FfFU https://cassyni.com/events/RAu9V44dfALQKbifyVFDtH?videoPreview=1 Dinosaur locomotionnohttps://cassyni.com/events/RAu9V44dfALQKbifyVFDtH?videoPreview=12024-12-30T12:00:00+00:00999.12Royal Society PublishingA review of the methods used to study dinosaur locomotion, covering extant taxa, bones, muscles, and footprints.https://cassyni-user-files-prod.s3.amazonaws.com/UncKQL1RqD1T7zjCa8FfFU https://cassyni.com/slides/outline/AMT26YetVRin1fRxxqRVLZ https://cassyni.com/events/AMT26YetVRin1fRxxqRVLZ/abstract https://cassyni-user-files-prod.s3.amazonaws.com/AvahBPkwK6ydn2ZDuAPfkA https://cassyni.com/events/AMT26YetVRin1fRxxqRVLZ?videoPreview=1 Open Research And End-to-End Ethics: A 'One Team' Approachnohttps://cassyni.com/events/AMT26YetVRin1fRxxqRVLZ?videoPreview=12022-09-27T03:00:00+00:006615.92UKRNOpen research is increasingly required by funders and journals, and supported by institutions and researchers themselves. However, building transparency into the research process requires consideration of ethical and governance issues related to the appropriate sharing of intermediate research outputs. For example, if appropriate permissions are not obtained at the start of the research process, it can be difficult or impossible to share these research outputs later. This workshop will cover how to build transparency into the research process, the challenges associated with choosing an appropriate repository for different outputs, and the need for integrated data infrastructure to support open research.https://cassyni-user-files-prod.s3.amazonaws.com/AvahBPkwK6ydn2ZDuAPfkA https://cassyni.com/events/LESj8r7Gfwiq1f8Pky8J77/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Dts4XbjiAoFU5FvUaCxDbL https://cassyni.com/slides/outline/GHFtmNw5AHHgDzfiMrYFWD https://cassyni.com/events/GHFtmNw5AHHgDzfiMrYFWD/abstract https://cassyni-user-files-prod.s3.amazonaws.com/DHe4wjnscp3zT6g3c75Rnn https://cassyni.com/events/GHFtmNw5AHHgDzfiMrYFWD?videoPreview=1 From microbes to mind and actions: Uncovering the gut-brain connection in major depressive disorder and its implications for human health and lifestylenohttps://cassyni.com/events/GHFtmNw5AHHgDzfiMrYFWD?videoPreview=12025-02-17T11:00:00+00:00403.92Microbiome Virtual International ForumThe gut microbiome, shaped by dietary choices, medication use, and host genetics, is emerging as a key determinant of physical and mental health. In this study, we explored the intricate links between the gut microbiome and major depressive disorder (MDD). Using a comprehensive dataset included 16S rRNA gene sequences from 7,472 individuals across Eastern and Western Europe, we employed a discovery-replication design followed by meta-analysis. Data processing and bioinformatics analyses were conducted using the QIIME2 platform. In the discovery set, 544 individuals (12%) reported a clinical diagnosis of MDD, compared to 3,912 without. Similarly, in the replication set, 285 (12%) reported MDD, while 2,167 did not. We applied linear regression models and meta-analysis across the two datasets using MaAsLin2 and ANCOM-BC2, adjusting for geographic region, age, gender, and batch effects using bacterial relative abundance was the primary outcome. Meta-analysis across the datasets identified 22 taxa significantly associated with MDD (q<0.05) using MaAsLin2, with nine taxa: Romboutsia, Clostridium sensu stricto, Agathobacter, Bacteroides pectinophilus group, Flavonifractor, Coprococcus, Victivallis, Tyzzerella, and Bacteroides, - confirmed by ANCOM-BC2. MR analysis using MiBioGen and depression GWAS data revealed no consistent causal relationships between bacterial taxa and MDD. However, mediation analyses showed that Bacteroides mediated 3–8% of single lifestyle effects and up to 61% of total effects on MDD, with notable contributions for healthy weight, physical activity, and diet. Specific taxa such as Bacteroides pectinophilus group, Victivallis, and Tyzzerella mediated 14–16%, 3–6%, and 4% of certain lifestyle effects, respectively. Additionally, a history of supplementation with Lactobacillus and Bifidobacteria probiotics was positively associated with MDD, indicating potential microbial alterations in individuals with depressive disorders. The integration of multiple bacterial taxa into a microbiome risk score outperformed single-taxon associations, achieving an AUC of 0.6 and demonstrating its potential to capture broader microbial patterns. Our findings reveal consistent microbial signatures linked to MDD. Individuals with a history of MDD exhibited notably reduced microbiome alpha diversity but higher relative abundance of SCFA-producing bacteria. These results suggest that the gut microbiota may play a significant role in the pathophysiology of MDD and highlight the importance of microbial composition in understanding and potentially managing MDD.https://cassyni-user-files-prod.s3.amazonaws.com/DHe4wjnscp3zT6g3c75Rnn https://cassyni.com/slides/outline/QgDvKjuDpLrFmbPbmft9k9 https://cassyni.com/events/QgDvKjuDpLrFmbPbmft9k9/abstract https://cassyni-user-files-prod.s3.amazonaws.com/DAUfgZszWSuy2rMGUinJ9t https://cassyni.com/events/QgDvKjuDpLrFmbPbmft9k9?videoPreview=1 Succinic semialdehyde derived from the gut microbiota can promote the proliferation of adult T-cell leukemia/lymphoma cellsnohttps://cassyni.com/events/QgDvKjuDpLrFmbPbmft9k9?videoPreview=12025-02-18T00:30:00+00:00370.24Microbiome Virtual International ForumAdult T-cell leukemia/lymphoma (ATLL) is a refractory blood cancer with severe immunodeficiency resulting from retroviral infection. ATLL develops in only 5 % of HTLV-1-infected individuals, but the entire mechanism of ATLL progression remains unknown. Since recent studies have reported that the gut microbiome influences the progression of various diseases, we hypothesized that ATLL is also related to the gut microbiome and aimed to investigate this relationship. We analyzed the taxonomic and functional profiles of the gut microbiota of ATLL patients (n = 28) and HTLV-1-infected individuals (n = 37). We found that the succinic semialdehyde (SSA) synthesis pathway was significantly enriched in the gut microbiome of ATLL patients (P = 0.000682), and *Klebsiella*, whose abundance was significantly greater in ATLL patients and high-risk HTLV-1-infected individuals (P = 0.0326), was the main contributor to this pathway. Administration of SSAs to ATLL cell lines resulted in significant cell proliferation. Herein, we propose that the gut microbiome can regulate ATLL progression via metabolites.https://cassyni-user-files-prod.s3.amazonaws.com/DAUfgZszWSuy2rMGUinJ9t https://cassyni.com/slides/outline/BqT5TrdEcXEUeMwt9UxDxH https://cassyni.com/events/BqT5TrdEcXEUeMwt9UxDxH/abstract https://cassyni-user-files-prod.s3.amazonaws.com/QskpPMqdJKXvhCs1miUM3L https://cassyni.com/events/BqT5TrdEcXEUeMwt9UxDxH?videoPreview=1 ECHO: Bridging Citizen Participation and Scientific Analysis in Soil Healthnohttps://cassyni.com/events/BqT5TrdEcXEUeMwt9UxDxH?videoPreview=12025-04-15T16:00:00+00:00381.96Microbiome Virtual International ForumECHO is a Research and Innovation Action co-funded by the EU under Horizon Europe and UK Research and Innovation (UKRI). Running from June 2023 to May 2027, ECHO engages European citizens in soil health by raising awareness, generating data, and fostering stewardship. It complements existing soil monitoring efforts while empowering citizens in data collection and decision-making. Built on three principles—engaging citizens in soil protection, empowering them with knowledge, and enabling their participation in policy—ECHO develops inclusive citizen science initiatives across Europe. The project addresses cultural and language differences, with 28 initiatives assessing 16,500 sites. A key outcome is ECHOREPO, an open-access data repository benefiting scientists, policymakers, landowners, and the public. ECHO promotes engagement through an interactive platform, an Ambassador network, and the ECHO app. It provides educational materials and creative collaborations to enhance public participation. ECHO collects data on eight key soil health indicators, including pollutants, soil organic carbon, structure, nutrients, pH, biodiversity, vegetation cover, and landscape heterogeneity. Citizens use the ECHO app to record GPS data, photos, and assess soil health. Two additional samples undergo laboratory analysis for microbial diversity and heavy metal content. The app also supports real-time data recording, geolocation tracking, and interaction between Ambassadors and participants. By 2027, ECHO will expand to all EU countries, providing low-cost tools and standardized protocols. While simplified methods may introduce variability, comparative assessments will refine data integration. Ultimately, ECHO aims to enhance citizen science credibility in environmental monitoring, supporting informed soil health policies and sustainable land management. https://cassyni-user-files-prod.s3.amazonaws.com/QskpPMqdJKXvhCs1miUM3L https://cassyni.com/slides/outline/NCg3qPzrC5tmo6fn7u3KrD https://cassyni.com/events/NCg3qPzrC5tmo6fn7u3KrD/abstract https://cassyni-user-files-prod.s3.amazonaws.com/54zE7KNZnkBgmQVRE6Jw58 https://cassyni.com/events/NCg3qPzrC5tmo6fn7u3KrD?videoPreview=1 Darwinian Quantum Gravity dynamics of small particlesnohttps://cassyni.com/events/NCg3qPzrC5tmo6fn7u3KrD?videoPreview=12025-09-29T14:00:00+00:00906.92Annals of PhysicsIn Darwinian Quantum Gravity (DQG), a.k.a. Physics-Cell (PC) approach, the Standard Model of Physics (SMP) occurs through a Quantum Field (QF) array Ψ of all SMP QFs within a 3D time-free medium, with Ψ alterations being emitted and received at PCs, which are assumed to have a spherical format, by the emission and transmission of two types of QFs between PCs: QF array ∆Ψ and QF scalar δΨ. The ∆Ψ are sent from the PCs based on the rules of the SMP calculated within the PCs, thus requiring that each PC processes the information required for a 4-vertices Feynman diagram of the SMP plus General Relativity (GR); whereas the δΨ is associated to the communication of the correction necessary to cancel the effects of the PC time-step size t_{PC} , with the energy density of δΨ being found to be equal to the dark energy’s density which is equal to the cosmological constant Λ. In PC approach, gravity occurs not through a QF but by synchronicity of QF quanta incoming onto a PC with quanta of the same QF outgoing from that PC, with the photon QF generating most of the symmetric aspect of the metric tensor and the neutrino QF generating most of the antisymmetric aspect of the metric tensor. The consequences of the PC approach are that QF decoherence is caused by reaching a pure-state maximum energy of E_{PC} = π∗ℏ/ t_{PC} , as any pure-state wavelength must be larger than l_{PC} = c∗t_{PC} and so there is no physical meaning for scales below. Therefore, there are no quantum effects beyond GR for masses above m_{PC} = E_{PC}/c^{2} . Thus, the quantum aspects of gravity occur only for very small masses, and such effects are described here. In the PC approach, there is no physical meaning to scales below l_{PC} and the spacetime is continuous through the interpolation process occurring by the communication between PCs of δΨ.https://cassyni-user-files-prod.s3.amazonaws.com/54zE7KNZnkBgmQVRE6Jw58 https://cassyni.com/slides/outline/Qfv54pEUPNfGA39Lfawxa9 https://cassyni.com/events/Qfv54pEUPNfGA39Lfawxa9/abstract https://cassyni-user-files-prod.s3.amazonaws.com/PkcWudDXQSYeYCt4oiXm1p https://cassyni.com/events/Qfv54pEUPNfGA39Lfawxa9?videoPreview=1 Optimization of CAR T-cell dose: a debated unresolved issuenohttps://cassyni.com/events/Qfv54pEUPNfGA39Lfawxa9?videoPreview=12026-01-02T09:04:33+00:00574.8Bone Marrow TransplantationCAR T-cell therapies are incredibly potent in killing tumour cells and have been extremely successful in putting hematologic patients into remission. However, there are still multiple challenges such as life-threatening toxicities and high relapse rates. Balancing the anti-tumor efficacy while sparing detrimental toxicities would be the desirable outcome. CAR T-cells behave as “living multi-drugs” because each cell type has its own kinetic and dynamic parameters. Therefore, the kinetics and function of a CAR T-cell product is unpredictable and variable. Optimising the CAR T-cell dose in terms of cell numbers and subpopulations, is extremely challenging as multiple factors seem to have an impact on CAR T-cell function, while published clinical trials have used a wide range of cell doses rendering the comparison of outcomes elusive. We propose a research model for determining the optimal therapeutic dose in CAR T-cell personalized therapies. We believe that both toxicity and relapse do not seem to be with the cellular products, per se, but rather with the followed therapeutic strategy. Scientists should turn backwards 180° degrees and take the reverse research direction to find the underlying root causes. The disconnection of the CAR-T product efficacy from long-term persistence is set as a prerequisite. Developing a model that identifies root causes of adverse events could lead to personalized therapies with optimized dosing and reduced side effects. Such advancements could facilitate outpatient treatment administration, reduce healthcare costs, and increase patient access to CAR T-cell therapies.https://cassyni-user-files-prod.s3.amazonaws.com/PkcWudDXQSYeYCt4oiXm1p https://cassyni.com/slides/outline/FnFCEWb2V8h5yGyKFzevF7 https://cassyni.com/events/FnFCEWb2V8h5yGyKFzevF7/abstract https://cassyni-user-files-prod.s3.amazonaws.com/XFrLdkF42VmwUwCm7pAHyQ https://cassyni.com/events/FnFCEWb2V8h5yGyKFzevF7?videoPreview=1 Linking Performance to Powerhouse: Mitochondria Aerobic Metabolism in Blood Cells Reflects Flight Endurance of House Sparrows (Passer domesticus)nohttps://cassyni.com/events/FnFCEWb2V8h5yGyKFzevF7?videoPreview=12025-09-22T14:00:00+00:001026.12Royal Society PublishingIdentifying the physiological mechanisms underpinning inter-individual differences in performance and fitness remains a key challenge in organismal biology. Variation in mitochondrial aerobic metabolism has been suggested to underlie inter-individual variation in performance, but this remains seldom tested, partly because of the need to use terminal sampling for assessing mitochondrial parameters. To fill this knowledge gap, we investigated whether inter-individual variation in mitochondrial aerobic parameters measured from less-invasively taken samples (i.e. blood cells) would correlate with both anaerobic and aerobic metrics of flight performance in house sparrows (Passer domesticus). We predicted that mitochondrial aerobic metabolism should correlate with aerobic but not anaerobic metrics of flight performance. As expected, we found no evidence for a relationship between mitochondrial metabolism and the energy required to take-off (i.e. anaerobic), but flight duration to exhaustion (i.e. aerobic) correlated positively with both cellular mitochondrial respiration rates and oxidative phosphorylation efficiency, a proxy of mitochondrial efficiency to convert nutrients into ATP. Our results therefore support the idea that inter-individual variation in mitochondrial aerobic metabolism could underlie variation in aerobic performance, and suggest that the nucleated blood cells of birds (and potentially other non-mammalian vertebrates) may be a relevant biological sample to test those links.https://cassyni-user-files-prod.s3.amazonaws.com/XFrLdkF42VmwUwCm7pAHyQ https://cassyni.com/events/T86RxJtRGxETewpT4hZFT3/abstract https://cassyni-user-files-prod.s3.amazonaws.com/SnbKgXKedFSBx1M5cBvMqg https://cassyni.com/slides/outline/MCNRdN9tpBSNUb9yAQjKAD https://cassyni.com/events/MCNRdN9tpBSNUb9yAQjKAD/abstract https://cassyni-user-files-prod.s3.amazonaws.com/4ucaWWGS3cQVSK7WHUdzY6 https://cassyni.com/events/MCNRdN9tpBSNUb9yAQjKAD?videoPreview=1 Long-term health outcomes in adolescents with obesity treated with faecal microbiota transplantation: 4-year follow-upnohttps://cassyni.com/events/MCNRdN9tpBSNUb9yAQjKAD?videoPreview=12025-10-15T02:00:00+00:00658.84Microbiome Virtual International ForumFaecal microbiota transplantation (FMT) has been explored as a potential treatment for obesity, but its long-term effects on metabolic health remain unclear. Here, we report 4-year follow-up findings from a double-blind, randomised, placebo-controlled trial assessing FMT in adolescents with obesity (ACTRN12615001351505, Australian New Zealand Clinical Trials Registry). This unblinded follow-up study evaluated 63% (55/87) of the original participants (27 FMT, 28 placebo). There was no difference in BMI between the two groups, after adjusting for sex, age, diet, and physical activity (−3.6 kg/m2, p = 0.095). However, FMT recipients showed clinical improvements in body composition and metabolic health compared to the placebo group. Specifically, FMT recipients had smaller waist circumference (−10.0 cm, p = 0.026), total body fat (−4.8%, p = 0.024), metabolic syndrome severity score (−0.58, p = 0.003), and systemic inflammation (−68% hs-CRP, p = 0.002) and higher levels of HDL cholesterol (0.16 mmol/L, p = 0.037). No group differences were observed in glucose markers, or other lipid parameters. Shotgun metagenomic sequencing revealed sustained long-term alterations in gut microbiome richness, composition and functional capacity, with persistence of donor-derived bacterial and bacteriophage strains. These findings highlight the potential relevance of FMT as a microbiome-augmenting intervention for obesity management and metabolic health, warranting further investigation.https://cassyni-user-files-prod.s3.amazonaws.com/4ucaWWGS3cQVSK7WHUdzY6 https://cassyni.com/events/ReCs3WycmJRcwEum54VtJh/abstract https://cassyni-user-files-prod.s3.amazonaws.com/7bH5bRSy1WwqgpWKfRtnmU https://cassyni.com/slides/outline/6NvJErk9eSpkAesG9kuacV https://cassyni.com/events/6NvJErk9eSpkAesG9kuacV/abstract https://cassyni-user-files-prod.s3.amazonaws.com/TXpRRjXAxKYUG88Jcn8wC2 https://cassyni.com/events/6NvJErk9eSpkAesG9kuacV?videoPreview=1 Vertical Structure and Dynamics of a Galactic Disknohttps://cassyni.com/events/6NvJErk9eSpkAesG9kuacV?videoPreview=12025-12-08T08:54:09+00:003469.88Physics ReportsMost of the visible mass in a typical spiral galaxy is distributed in a thin disk, with a radial extent much larger than its thickness. While the planar disk structure, including non-axisymmetric features such as spiral structure, has been studied extensively, the vertical structure has not received comparable attention. This review aims to give a comprehensive, pedagogic introduction to the rich topic of vertical structure of a galactic disk in hydrostatic equilibrium, and discuss the theoretical developments in this field in the context of recent observations. A realistic multi-component disk plus halo model of a galaxy has been developed and studied by us in detail. This takes account of both stars and interstellar gas, treated as isothermal components with different velocity dispersions, which are gravitationally coupled; further, the disk is in the gravitational field of the dark matter halo. This review focuses on this model and the results from it in different physical cases. The gas and halo crucially affect the resulting self-consistent stellar distribution such that it is vertically constrained to be closer to the mid-plane, and has a steeper profile than in the standard one-component case, in agreement with modern observations. A typical stellar disk is shown to flare by a factor of few within the visible radial extent of the disk. These robust results question the sech^2 profile and a constant scale height, routinely used in the literature for convenience. In an important application, the observed HI gas scale height is used as a constraint on the model which helps determine the shape and the density profile of the dark matter halo for galaxies. Finally, we outline some key, open questions which can be addressed in the near future using the above model, and new observational data -- for example, from the IFU surveys and JWST. These promise to give a better understanding of this topic.https://cassyni-user-files-prod.s3.amazonaws.com/TXpRRjXAxKYUG88Jcn8wC2 https://cassyni.com/slides/outline/JEWRTtndao3ZGMqvJrUKob https://cassyni.com/events/JEWRTtndao3ZGMqvJrUKob/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Y4zpWkNC4ivyMp7PBpvPGi https://cassyni.com/events/JEWRTtndao3ZGMqvJrUKob?videoPreview=1 A high-quality genomic catalog of the human oral microbiome broadens its phylogeny and clinical insightsnohttps://cassyni.com/events/JEWRTtndao3ZGMqvJrUKob?videoPreview=12025-12-10T00:30:00+00:00287.92Microbiome Virtual International ForumThe oral microbiome plays an increasingly recognized role in human health. To better characterize this complex ecosystem, we constructed the Human Reference Oral Microbiome (HROM), comprising 72,641 high-quality genomes representing 3,426 species, including 2,019 previously uncharacterized taxa. HROM substantially enhances metagenomic read classification compared to existing catalogs. Remarkably, it identifies 1,137 previously undescribed candidate phyla radiation (CPR) species, positioning Patescibacteria as the most dominant phylum in the oral microbiota, distinct from their environmental counterparts. Within this group, an oral CPR subclade shows a strong association with periodontitis, complementing Porphyromonas gingivalis in disease prediction. Comparative analyses between HROM and gut microbiome references further reveal marked taxonomic and functional divergence, while identifying 42 oral species detected in the gut whose relative abundance correlates with intestinal, cardiovascular, and liver disorders. Altogether, HROM provides an expanded genomic framework for the oral microbiome and underscores its potential links to systemic diseases.https://cassyni-user-files-prod.s3.amazonaws.com/Y4zpWkNC4ivyMp7PBpvPGi https://cassyni.com/slides/outline/7rcWMF3kLa9TC6imCA7THP https://cassyni.com/events/7rcWMF3kLa9TC6imCA7THP/abstract https://cassyni-user-files-prod.s3.amazonaws.com/VYFhZ5T1PRYpdCohDgqTCA https://cassyni.com/events/7rcWMF3kLa9TC6imCA7THP?videoPreview=1 Trait evolution drives speciation through complex interactions between genome size, adaptation and allometrynohttps://cassyni.com/events/7rcWMF3kLa9TC6imCA7THP?videoPreview=12026-07-06T08:40:14+00:001237.64Royal Society PublishingSpeciation shapes biodiversity, yet why some lineages diversify faster than others remains unclear. Theory predicts that traits promote ecological speciation through adaptation, but their evolvability (‘‘trait flexibility’’) may be impacted by allometric and genomic constraints. Here we test this by integrating phylogenetic, trait and genome size data for palms (Arecaceae) —a large pantropical family (>2,600 species) with 167-fold variation in certain traits (e.g., fruit size) and 60-fold genome size variation. Using structural equation modelling, we test three hypotheses: trait evolution promotes speciation (H1: trait flexibility hypothesis), and, speciation and trait evolution rates are constrained by allometry (H2: allometric constraint hypothesis) and genome size (H3: large genome constraint hypothesis). We detected seven major speciation rate shifts during ~approximately 110-million-years of palm evolution. Tip-derived speciation rates increased with faster evolution in leaf size and plant height, supporting H1, whereas correlated evolution between all traits indirectly influenced speciation, supporting H2. Large genomes decreased were associated with decreased plant height and stem diameter evolution rates supporting H3, but the genome size-speciation association was sensitive to phylogenetic autocorrelation. Our findings illustrate how the interplay between genome size, allometry and trait evolvability affect speciation, emphasizing the importance of holistic approaches for uncovering general mechanisms driving speciation throughout the Tree of Life.https://cassyni-user-files-prod.s3.amazonaws.com/VYFhZ5T1PRYpdCohDgqTCA https://cassyni.com/slides/outline/JjTsmW6uTDneYJDbzoNP4q https://cassyni.com/events/JjTsmW6uTDneYJDbzoNP4q/abstract https://cassyni-user-files-prod.s3.amazonaws.com/3zsixf79c5P6KD1SGZK1Yi https://cassyni.com/events/JjTsmW6uTDneYJDbzoNP4q?videoPreview=1 The Molecular Language of Food: A New Frontier for Human Biology and Therapeutic Discoverynohttps://cassyni.com/events/JjTsmW6uTDneYJDbzoNP4q?videoPreview=12026-09-17T01:00:00+00:001064.84Microbiome Virtual International ForumFood contains thousands of biologically active molecules that influence human biology. The Periodic Table of Food Initiative (PTFI) is a global collaboration creating the world's largest standardized molecular atlas of edible biodiversity through harmonized multi-omics methods and open-access data. This presentation will explore how PTFI enables therapeutic discovery by linking food-derived molecules to biological pathways. Applications include bioactivity-informed meal design through the Swap It Smart platform, predictive modeling of food–biology interactions, and experimental and clinical validation to advance precision nutrition, biomarker discovery, and therapeutic innovation.https://cassyni-user-files-prod.s3.amazonaws.com/3zsixf79c5P6KD1SGZK1Yi https://cassyni.com/events/6sHg9FEp4J7aNZcWqn6Mch/seminar/qa https://cassyni.com/slides/outline/6sHg9FEp4J7aNZcWqn6Mch https://cassyni.com/events/6sHg9FEp4J7aNZcWqn6Mch/abstract https://cassyni-user-files-prod.s3.amazonaws.com/DxGHpxzYMpkLX4HJsQNB5Q https://cassyni.com/events/6sHg9FEp4J7aNZcWqn6Mch?videoPreview=1 Psychedelics in Mental Health: Opportunities and Challengesnohttps://cassyni.com/events/6sHg9FEp4J7aNZcWqn6Mch?videoPreview=12026-07-21T07:30:00+00:003285.12Brain and Behavior JournalBrain and Behavior special issue “Psychedelics in Mental Health: Opportunities and Challenges,” brings together empirical studies, reviews, clinical perspectives, and commentaries addressing these emerging priorities. Across the special issue, a central theme is that psychedelic therapy cannot be understood as a pharmacological intervention alone. Contributions highlight the importance of therapeutic relationships, preparation, integration, music, touch, external therapist involvement, peer support, cultural context, and patient expectations in shaping outcomes. Several manuscripts examine the phenomenology of psychedelic and ketamine experiences, emphasizing that subjective meaning-making, expectancy, and altered states are not incidental features but potentially central aspects of therapeutic change and clinical risk. Other articles consider implementation challenges, including models of care for veterans, the perspectives of peer support workers, global mental health equity, and culturally responsive access. Mechanistic and translational work further broadens the field by examining neuroplasticity, rapid-acting interventions for suicidality, and developmental perspectives on psychedelic use. Collectively, the articles in this special issue illustrate a field at an important point of inflection. Psychedelic research requires greater conceptual precision, careful attention to safety and consent, and implementation of frameworks that prioritize equity and cultural appropriateness. The promise of psychedelics in mental health lies not only in their potential for rapid symptom reduction, but in their capacity to challenge and expand prevailing models of therapeutic change, integrating biological, psychological, relational, cultural, and systems-level perspectives on healing. https://cassyni-user-files-prod.s3.amazonaws.com/DxGHpxzYMpkLX4HJsQNB5Q https://cassyni.com/slides/outline/DHmmyPgQZyAd9CmBQTBX9f https://cassyni.com/events/DHmmyPgQZyAd9CmBQTBX9f/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Gpx2oR6zyFK2V4Bo3Xa5Ui https://cassyni.com/events/DHmmyPgQZyAd9CmBQTBX9f?videoPreview=1 Costs and benefits of group size for sperm whales of the open oceannohttps://cassyni.com/events/DHmmyPgQZyAd9CmBQTBX9f?videoPreview=12026-07-22T15:00:00+00:001563.68Royal Society PublishingIndividual feeding success can change with the size of a social group through competition, cooperation, recruitment and other processes. Female sperm whales (Physeter macrocephalus) live in long-term social units that themselves can form larger, temporary groups, but the individual level impacts of group formation are unknown. We measured feeding success on 88 days following groups off the Galápagos Islands and Chile using defecation rates. Feeding success increased about fourfold as group sizes rose from one social unit (about 10 animals) to 4-5 units. Our data did not suggest recruitment into successful groups, and the whales’ prey are generally relatively small and slow, arguing against cooperative capture. Instead, it seems most plausible that individuals receive valuable information about patchy prey distributions from foraging group members over scales of 100’s-1,000’s metres. Feeding success fell for the largest groups, suggesting a foraging optimum of about 40-50 animals off the Galápagos Islands and 30-40 animals off Chile. These are close to the mean typical group sizes in these areas, which indicates that efficient foraging on patchy prey may largely drive group size. Considerable differences between oceans in the group sizes of female sperm whales are likely linked to variation in patchiness of resource availability.https://cassyni-user-files-prod.s3.amazonaws.com/Gpx2oR6zyFK2V4Bo3Xa5Ui https://cassyni.com/events/WaXApaMYjiQHTUShN8aEF7/seminar/qa https://cassyni.com/slides/outline/WaXApaMYjiQHTUShN8aEF7 https://cassyni.com/events/WaXApaMYjiQHTUShN8aEF7/abstract https://cassyni-user-files-prod.s3.amazonaws.com/2uK2AJEAZvHrZCSCuuuvTg https://cassyni.com/events/WaXApaMYjiQHTUShN8aEF7?videoPreview=1 How the leopard got its spots: Revisiting Turing’s Chemical Basis of Morphogenesisnohttps://cassyni.com/events/WaXApaMYjiQHTUShN8aEF7?videoPreview=12026-08-26T21:00:00+00:003335.64Bulletin of Mathematical BiologyIn a 1952 paper, Alan Turing showed that biochemicals, reacting and diffusing in a field of cells, could—in principle—spontaneously organize themselves into a stable spatial pattern of high and low concentrations. Turing suggested that these spatial patterns might possibly provide a mechanism for ‘morphogenesis’—the development of biological forms, such as tentacles, leaf whorls, feather primordia, and animal coat patterns. Although Turing’s paper is a classic of theoretical biology, it is notoriously difficult to read and understand. In this talk, I briefly review Turing’s life and his role in deciphering the German Enigma machine in WWII. Then I describe Turing’s analysis of spontaneous pattern formation in a modern context, to make it more accessible to biologists, biochemists and mathematicians. I will illustrate Turing’s predictions with simulations in one and two spatial dimensions and discuss briefly how they may be relevant to our present understanding of pattern formation in specific circumstances.https://cassyni-user-files-prod.s3.amazonaws.com/2uK2AJEAZvHrZCSCuuuvTg https://cassyni.com/slides/outline/2v3bYX2qjuqLhhrpCLmFzm https://cassyni.com/events/2v3bYX2qjuqLhhrpCLmFzm/abstract https://cassyni-user-files-prod.s3.amazonaws.com/JSeGfH1dgmbbZaxcLBq6fG https://cassyni.com/events/2v3bYX2qjuqLhhrpCLmFzm?videoPreview=1 CD40/PI3K/FOXO1 axis rewiring drives microenvironment-dependent BIM silencing to sustain lymphoma growth and survivalnohttps://cassyni.com/events/2v3bYX2qjuqLhhrpCLmFzm?videoPreview=12026-02-23T15:00:00+00:001828.04LeukemiaBoth solid and hematological malignancies are recognized as complex ecosystems in which the tumor microenvironment (TME) plays a pivotal role in mediating therapeutic resistance. TME-driven modulation of BCL2-family proteins has emerged as a key determinant of treatment response in B-cell malignancies. Here, we focused on the regulation of the pro-apoptotic BH3-only protein BIM, using mantle cell lymphoma (MCL), an aggressive and incurable B-cell neoplasm, as a cellular model. Comparative analysis of circulating and lymph node samples highlighted selective BIM downregulation in malignant cells within the nodal TME, contrasting with BIM upregulation observed with normal B cells. TME-mimicking ex vivo co-culture of primary samples recapitulated this tumor-specific and microenvironment-dependent mechanism. Mechanistically, we found that BIM downregulation is driven by a lymphoma-specific CD40L-mediated rewiring of the PI3K/AKT pathway, which in turn inhibits the transcriptional activity of FOXO1. Functionally, CRISPR/Cas9-mediated deletion of BIM in MCL primary cells was sufficient to bypass their dependence on microenvironmental survival cues, leading to long-term autonomous expansion ex vivo. Moreover, BIM loss conferred broad resistance to chemotherapy and clinically relevant targeted agents. In contrast, treatment with bispecific T-cell engagers elicited robust cytotoxic responses regardless of BIM expression, underscoring the potential of immunotherapies to overcome TME-induced apoptotic resistance.https://cassyni-user-files-prod.s3.amazonaws.com/JSeGfH1dgmbbZaxcLBq6fG https://cassyni.com/events/ApStQ5u8Abd11kNnxKjxay/seminar/qa https://cassyni.com/slides/outline/ApStQ5u8Abd11kNnxKjxay https://cassyni.com/events/ApStQ5u8Abd11kNnxKjxay/abstract https://cassyni-user-files-prod.s3.amazonaws.com/XvjX8iSjaJaCnVjSiPthHg https://cassyni.com/events/ApStQ5u8Abd11kNnxKjxay?videoPreview=1 Microcanonical phase space and entropy in curved spacetime: Non-backreacting casenohttps://cassyni.com/events/ApStQ5u8Abd11kNnxKjxay?videoPreview=12026-04-09T16:26:07+00:001204.84Annals of PhysicsThis study explores the microcanonical phase space and entropy of non-backreacting point-particle systems in curved spacetime. The microcanonical ensemble is adopted to circumvent the inequivalence of ensembles inherent in gravitating systems, which results from long-range gravitational interactions and can lead to thermodynamic instabilities in canonical approaches. A framework is developed to compute the cumulative density of states Γ(E) for confined systems. For spacetimes possessing a Killing vector field, a conserved Killing energy is utilized. In arbitrary curved spacetimes, an approximate Killing vector field and energy are defined using Fermi Normal Coordinates, applicable for systems small relative to curvature variations. Analysis of one-particle systems in Rindler, Schwarzschild, and de Sitter spacetimes demonstrates a universal divergence of Γ(E) as the system approaches any horizon. In general curved spacetimes, leading-order corrections to Γ(E), the density of states, microcanonical entropy, and inverse temperature are found to be area-dependent and proportional to local curvature and acceleration squared. For ultra-relativistic N-particle systems in static spacetimes, the entropy incorporates area-dependent curvature corrections, yet the inverse temperature, β = 3N/E, shows no leading-order curvature-dependent corrections. Notably, the equipartition relation ⟨E⟩ = 3T, previously known for special relativity, is shown to hold in curved static spacetimes with appropriately defined conserved energy. These results lay the groundwork for incorporating back-reaction through a mean-field approximation, offering insights into structure formation, stellar collapse, and black hole thermodynamics.https://cassyni-user-files-prod.s3.amazonaws.com/XvjX8iSjaJaCnVjSiPthHg https://cassyni.com/events/Emgxzp76UyuEguiLZbgPS5/abstract https://cassyni-user-files-prod.s3.amazonaws.com/9A7hBFpj1hpzYJ5ryUNuh8 https://cassyni.com/events/6sskYU4RWsZqSbEwqhodsj/abstract https://cassyni-user-files-prod.s3.amazonaws.com/XJZhtCczs89eCtDYnZvcoY https://cassyni.com/events/EHbpEimJ6jsfwAmQoafNHj/abstract https://cassyni-user-files-prod.s3.amazonaws.com/FYsBBismG4T9jQn23gVBBc https://cassyni.com/events/BpMo1JXfuT78u1XdLns1HX/abstract https://cassyni-user-files-prod.s3.amazonaws.com/pCJfJUaZS1E3aUfLPUG5c https://cassyni.com/slides/outline/FHZy5CRceKDG9oyoTtXx4u https://cassyni.com/events/FHZy5CRceKDG9oyoTtXx4u/abstract https://cassyni-user-files-prod.s3.amazonaws.com/HcarfooG2cxzJopJzWJ79Y https://cassyni.com/events/FHZy5CRceKDG9oyoTtXx4u?videoPreview=1 Comparative genome analysis of the immunomodulatory ability of Lactiplantibacillus plantarum and Lactiplantibacillus pentosus from Japanese picklesnohttps://cassyni.com/events/FHZy5CRceKDG9oyoTtXx4u?videoPreview=12025-06-03T14:00:00+00:00413.32Microbiome Virtual International ForumLactic acid bacteria (LAB) are pivotal in food preservation and exhibit immunomodulatory effects on interleukin-10 (IL-10) and interleukin-12 (IL-12) production. *Lactiplantibacillus plantarum* (*L. plantarum*) and *Lactiplantibacillus pentosus* (*L. pentosus*) from fermented food are known for their effect; however, a comprehensive comparative genome analysis is needed to identify the linked genes. Here, we investigated the immunomodulatory capability at the genome level of *L. plantarum* and *L. pentosus* strains isolated from Japanese pickles at the genome level, and we further identified their immunomodulation-associated genes using the potential-gene (PG) index derived from the Calinski–Harabasz (CH) index. The results revealed an immunostimulatory clade with strain-specific IL-10 and IL-12 induction and identified key genes via the PG index. Both genes across two species were shown to encode the enzyme TagF2, which is crucial for synthesizing poly-glycerol-3-phosphate type wall teichoic acid (poly-GroP WTA), indicating that TagF2 plays a potential role as an effective microbe-associated-molecular-pattern. In vivo analyses confirmed the IL-10-inducing ability of one strain, reinforcing the IL-10-stimulating capacity of its poly-GroP WTA. Subpotential genes in *L. plantarum* TagF2-possessing strains were linked to host‒cell interactions, suggesting that such strains play potential probiotic roles. Collectively, the PG index effectively identified immunomodulation-related genes, thus paving the way for the use of the PG index to detect potential health benefit-associated genes in other LAB species.https://cassyni-user-files-prod.s3.amazonaws.com/HcarfooG2cxzJopJzWJ79Y https://cassyni.com/slides/outline/MD1kFr1H5Uk5szqxSBC8Vs https://cassyni.com/events/MD1kFr1H5Uk5szqxSBC8Vs/abstract https://cassyni-user-files-prod.s3.amazonaws.com/VZdgj8kkaf8BcC7W3srR9g https://cassyni.com/events/MD1kFr1H5Uk5szqxSBC8Vs?videoPreview=1 How to Save Battery Energy of a Pacemakernohttps://cassyni.com/events/MD1kFr1H5Uk5szqxSBC8Vs?videoPreview=12023-07-26T13:00:00+00:00814.68International Journal of ThermofluidsPacemakers are medical devices used to treat cardiac disorders such as arrythmias. They do this by sending an electrical pulse from the device through a lead to the heart. The electrical stimulus makes the heart contract and produce a pulse. The device itself is implantable which has a life span in the body of approximately 8 – 12 years. One of the main draw backs to the device is the battery lifespan, as patients require long-term usage of the device, it will require a number of replacements over the years. Here, we found the potential to eliminate the excess portion of the lead that is wrapped around the pulse generator (battery) during the implantation. By using a shorter lead energy could be saved that is potentially being dissipated through this excess. When using a 48cm lead over a 58cm lead we demonstrate that there is an overall energy save of 19.5%. This demonstrates that the excess lead could be eliminated which would reduce energy loss through the lead with the overall potential to increase battery life.https://cassyni-user-files-prod.s3.amazonaws.com/VZdgj8kkaf8BcC7W3srR9g