https://cassyni.com/slides/outline/6GQDcAgeoNzS9pEUJ95GKF https://cassyni.com/events/6GQDcAgeoNzS9pEUJ95GKF/abstract https://cassyni-user-files-prod.s3.amazonaws.com/CtGMYhSKYHbe3MT4w21TBc https://cassyni.com/events/6GQDcAgeoNzS9pEUJ95GKF?videoPreview=1 What’s up with Image & Video Forensics?nohttps://cassyni.com/events/6GQDcAgeoNzS9pEUJ95GKF?videoPreview=12023-03-02T12:30:00+00:003162.64Journal on Image and Video ProcessingThis talk will be a journey through more than 20 years of research in video & image forensics, which was born to respond to challenges of the digital era such as integrity and authenticity verification and source attribution. We will examine some of the characteristics that have made it possible, from the use of intrinsic features in the acquisition devices, such as lens aberration or demosaicing filters to the traces left by the postprocessing, in order to grasp how methods have evolved from making use of relatively simple statistical models to much more complex ones that rely on deep learning. In particular, we will see this evolution with **two classic problems**: 1. The identification of the device that captured a given image, to which the use of the PRNU (Photo Response Non-Uniformity) opened the door and which has currently expanded the type of fingerprints that can be extracted and used successfully 2. The detection and localization of image manipulations through the traces of double compression, which now benefits from the ability of DNNs to learn models with richer dependencies. But not only forensic techniques have evolved: first, the popularization of computational photography with lens distortion corrections, high-dynamic range algorithms, video stabilization or AI-based filters, etc.; second, the ever more prevalent use of social networks for image and video exchange often with proprietary transcoding; and third, the advent of Deep Fakes, imply that many of the techniques developed in the past must be continuously revised to respond to all these novel and demanding challenges. Last, we will briefly discuss the ethical and legal implications of image and video forensics, especially when it comes to the use of AI.https://cassyni-user-files-prod.s3.amazonaws.com/CtGMYhSKYHbe3MT4w21TBc https://cassyni.com/slides/outline/8kEKEojtTFDBaUkcsv5r53 https://cassyni.com/events/8kEKEojtTFDBaUkcsv5r53/abstract https://cassyni-user-files-prod.s3.amazonaws.com/2rmzXHQwXVaQP5zb4LBT6v https://cassyni.com/events/8kEKEojtTFDBaUkcsv5r53?videoPreview=1 PCAN Podcast Episode 1: Prof. Elterman minimally invasive for BPHnohttps://cassyni.com/events/8kEKEojtTFDBaUkcsv5r53?videoPreview=12024-02-18T13:00:00+00:001940.0Research Seminars by Springer NatureIntroduction Benign prostatic hyperplasia (BPH) is one of the most common diseases affecting men and can present with bothersome lower urinary tract symptoms (LUTS). Historically, transurethral resection of the prostate (TURP) has been considered the gold standard in the treatment of LUTS due to BPH. However, TURP and other traditional options for the surgical management of LUTS secondary to BPH are associated with high rates of sexual dysfunction. In the past decade, several novel technologies, including Aquablation therapy, convective water vapor therapy (Rezum), and transperineal prostate laser ablation (TPLA), have demonstrated promising evidence to be safe and effective while preserving sexual function. Methods In this review, we discuss three ablative minimally invasive surgeries: Aquablation, Rezum, and TPLA. We review their techniques, safety, as well as perioperative and functional outcomes. We go into further detail regarding sexual function after these ablative minimally invasive surgical therapies. Results Aquablation is a surgeon-guided, robot-executed, heat-free ablative waterjet procedure with sustained functional outcomes at 5 years while having no effect on sexual activity. Rezum is an innovative office-based, minimally invasive surgical option for BPH that delivers convective water vapor energy into prostate adenoma to ablate obstructing tissue. Rezum leads to significant improvements in Qmax, IPSS while preserving sexual function. TPLA is another office-based technology which uses a diode laser source to produce thermoablation. It leads to improvement in Qmax, IPSS, and QoL while preserving ejaculatory function. Conclusions Overall, ablative minimally invasive surgical therapies have demonstrated excellent safety and efficacy profiles while preserving sexual function. These modalities should be discussed with patients to ensure informed and shared decision-making. Ablative minimally invasive surgical therapies may be particularly interesting to patients who value the preservation of their sexual function.https://cassyni-user-files-prod.s3.amazonaws.com/2rmzXHQwXVaQP5zb4LBT6v https://cassyni.com/events/QYLL6CbJEbdLYdNYFgaCTw/seminar/qa https://cassyni.com/slides/outline/QYLL6CbJEbdLYdNYFgaCTw https://cassyni.com/events/QYLL6CbJEbdLYdNYFgaCTw/abstract https://cassyni-user-files-prod.s3.amazonaws.com/6aFw1utR11U6Y1JnngqXok https://cassyni.com/events/QYLL6CbJEbdLYdNYFgaCTw?videoPreview=1 Attracting High Quality Submission through Collectionsnohttps://cassyni.com/events/QYLL6CbJEbdLYdNYFgaCTw?videoPreview=12023-04-25T08:00:00+00:002623.48Topics at the heart of our communityThe impact of a collection can be higher than other papers in a journal. In this session, we’ll explore how collections can be leveraged towards greater impact for their journals more broadly, including attracting high quality submissions and increasing their journal’s visibility in the community.https://cassyni-user-files-prod.s3.amazonaws.com/6aFw1utR11U6Y1JnngqXok https://cassyni.com/events/NZmY26X5t8Lg19tVW6nXvD/seminar/qa https://cassyni.com/slides/outline/NZmY26X5t8Lg19tVW6nXvD https://cassyni.com/events/NZmY26X5t8Lg19tVW6nXvD/abstract https://cassyni-user-files-prod.s3.amazonaws.com/3fxapmYtiaqLdjpE4QvtAJ https://cassyni.com/events/NZmY26X5t8Lg19tVW6nXvD?videoPreview=1 Motivation in L2 writing: Making extrinsic motivation to be more self-determined, Manner and quality of negotiation during L2 collaborative writingnohttps://cassyni.com/events/NZmY26X5t8Lg19tVW6nXvD?videoPreview=12023-08-11T04:10:00+00:003032.4Linguistics and Applied Language StudiesAlthough peer interaction has received attention in second language (L2) collaborative writing (CW) research, the manner and quality of peer interaction have been less investigated. Previous studies usually examined peer interaction by looking at language-related episodes, overlooking the ways students negotiate for different types of knowledge for successful writing, such as content, organisation, and discourse. Moreover, the association between quality of negotiation and students’ writing process is elusive. This study aims to examine the way students discussed different aspects of writing during interaction and explore the impact of quality of negotiation on students’ subsequent writing and revisions. Data were collected from an intact academic writing class at a New Zealand university, where students formed groups to produce a single text per group over twelve weeks. Results showed that students discussed content and organisation more than language, and different qualities of negotiation were associated with different writing and revision outcomes. In addition, students discussed both local and global aspects of writing, and quality of negotiation is an important factor that mediates students’ writing and revision behaviours. https://cassyni-user-files-prod.s3.amazonaws.com/3fxapmYtiaqLdjpE4QvtAJ https://cassyni.com/events/TzpKBj6CW5ewNM9Ja86qG1/seminar/qa https://cassyni.com/slides/outline/TzpKBj6CW5ewNM9Ja86qG1 https://cassyni.com/events/TzpKBj6CW5ewNM9Ja86qG1/abstract https://cassyni-user-files-prod.s3.amazonaws.com/wgyANnZBUtznHHLH2o3Fk https://cassyni.com/events/TzpKBj6CW5ewNM9Ja86qG1?videoPreview=1 Linguistic and communicative demands in the professional field. What Swedish does the foreign physician need?nohttps://cassyni.com/events/TzpKBj6CW5ewNM9Ja86qG1?videoPreview=12023-03-24T03:10:00+00:003530.64Linguistics and Applied Language StudiesThrough analysing literacy demands and communicative practices in the working life, the project "Working in a second language: literacy practices and educational models designed for professional contexts" investigates following questions: How do second language learners cope with literacy and communicative practices in the workplace? How could we best design educational programs in Swedish as a second language with a vocational profile? In this presentation I will focus on linguistic and communicative demands for medical doctors in Sweden; second language speakers in particular. Two types of data is presented: 1. "The Proficiency Test", compulsory for medical doctors from outside EU applying for a license to perform medicine in Sweden, and 2. A team meeting at a cardiac clinic, with the aim to update the team about the patients’ status as a preparation for the daily “round” (conversation at the bedside). At this meeting, one participant is a foreign doctor attending the course “Swedish for immigrants with health care profile”, doing her weekly internship. The proficiency test aims at testing prior medical knowledge only, but analysis shows that the linguistic demands are fairly complex. The team meeting can be regarded as linguistically and communicative complex, due to participants’ different roles and perspectives, but also to shifts between formal and informal, medical and everyday Swedish. What do these data tell us about potential linguistic and communicative challenges for the second language learner, within the professional field of practicing medicine? https://cassyni-user-files-prod.s3.amazonaws.com/wgyANnZBUtznHHLH2o3Fk https://cassyni.com/slides/outline/L6Z8uJoM6CVunzhBCpRg45 https://cassyni.com/events/L6Z8uJoM6CVunzhBCpRg45/abstract https://cassyni-user-files-prod.s3.amazonaws.com/FU381hQtRRFu1EFFPiqevS https://cassyni.com/events/L6Z8uJoM6CVunzhBCpRg45?videoPreview=1 GOing FAIR & DOing FAIRnohttps://cassyni.com/events/L6Z8uJoM6CVunzhBCpRg45?videoPreview=12022-11-14T17:00:00+00:003748.16DeSci FoundationSince their introduction in 2016, the FAIR Guiding Principles have been widely recognised and have inspired countless initiatives to make data and services more Findable, Accessible, Interoperable and Reusable by machines. The GO FAIR Foundation was created in 2019 as an independent and non-profit organization to support FAIRifcation efforts which includes explicit interpretations of the FAIR Principles and a few other essential criteria when “going FAIR”. Although FAIR implementations can assume a broad range of architectures and technology choices, recently a critical mass of stakeholders has converged on a potential FAIR Digital Object specification that could make “doing FAIR” a more standardised and streamlined proposition. In this presentation, Erik will recount the brief but explosive history of FAIR and the current interest around FDOs as Universal Machine Actionable Containers (UMACs).https://cassyni-user-files-prod.s3.amazonaws.com/FU381hQtRRFu1EFFPiqevS https://cassyni.com/slides/outline/WxpRvM2tkGgPKGXCpMfMzu https://cassyni.com/events/WxpRvM2tkGgPKGXCpMfMzu/abstract https://cassyni-user-files-prod.s3.amazonaws.com/BSss3WM353oB1C9cAdDy26 https://cassyni.com/slides/outline/RXgnQpv7vEbJvQGyDSfa1T https://cassyni.com/events/RXgnQpv7vEbJvQGyDSfa1T/abstract https://cassyni-user-files-prod.s3.amazonaws.com/8xoAPCepnwEtG5ZvXpTjy8 https://cassyni.com/events/KvB9LDQQoTQkiX8HfNGb7/seminar/qa https://cassyni.com/slides/outline/KvB9LDQQoTQkiX8HfNGb7 https://cassyni.com/events/KvB9LDQQoTQkiX8HfNGb7/abstract https://cassyni-user-files-prod.s3.amazonaws.com/YXwi2arS55oXYr9zhkWJN2 https://cassyni.com/events/KvB9LDQQoTQkiX8HfNGb7?videoPreview=1 Emergent chemotaxis in synthetic active matternohttps://cassyni.com/events/KvB9LDQQoTQkiX8HfNGb7?videoPreview=12023-09-21T14:00:00+00:003587.24Journal of Biological PhysicsActive particles with their characteristic feature of self-propulsion are regarded as the simplest models for motility in living systems. The accumulation of active particles in low activity regions has led to the general belief that chemotaxis requires additional features and at least a minimal ability to process information and to control motion. We show that self-propelled particles display chemotaxis and move into regions of higher activity if the particles perform work on passive objects, or cargo, to which they are bound. The origin of this cooperative chemotaxis is the exploration of the activity gradient by the active particle when bound to a load, resulting in an average excess force on the load in the direction of higher activity. In a simple theoretical model, we capture the most relevant features of these active-passive dimers, and in particular we predict the crossover between antichemotactic and chemotactic behavior. Moreover, we show that merely connecting active particles to chains is sufficient to obtain the crossover from antichemotaxis to chemotaxis with increasing chain length. Such an active complex is capable of moving up a gradient of activity such as provided by a gradient of fuel and to accumulate where the fuel concentration is at its maximum. The observed transition is of significance to protoforms of life, enabling them to locate a source of nutrients even in the absence of any supporting sensomotoric apparatus.https://cassyni-user-files-prod.s3.amazonaws.com/YXwi2arS55oXYr9zhkWJN2 https://cassyni.com/events/G9NJXqd9aY4m1LEVohqdTB/seminar/qa https://cassyni.com/slides/outline/G9NJXqd9aY4m1LEVohqdTB https://cassyni.com/events/G9NJXqd9aY4m1LEVohqdTB/abstract https://cassyni-user-files-prod.s3.amazonaws.com/47QSiwxsi2HqPp6hcViUQN https://cassyni.com/events/G9NJXqd9aY4m1LEVohqdTB?videoPreview=1 Multivariate Dependence beyond Correlation: Nonparametric Copulasnohttps://cassyni.com/events/G9NJXqd9aY4m1LEVohqdTB?videoPreview=12023-10-05T14:30:00+00:003875.68Journal of Statistical Theory and PracticeIn the field of climate, finance, insurance, and system reliability, etc., it is often of interest to measure the dependence among variables by modeling a multivariate distribution using a copula. The copula models with parametric assumptions are easy to estimate but can be highly biased when such assumptions are false, while the empirical copulas are non-smooth and often not genuine copula, making the inference about dependence challenging in practice. As a compromise, the empirical Bernstein copula provides a smooth estimator, but the estimation of tuning parameters remains elusive. In this paper, by using the so-called empirical checkerboard copula, we build a hierarchical empirical Bayes model that enables the estimation of a smooth copula function for arbitrary dimensions. The proposed estimator based on the multivariate Bernstein polynomials is itself a genuine copula, and the selection of its dimension-varying degrees is data-dependent. We also show that the proposed copula estimator provides a more accurate estimate of several multivariate dependence measures, which can be obtained in closed form. We investigate the asymptotic and finite-sample performance of the proposed estimator and compare it with some nonparametric estimators through simulation studies. An application to portfolio risk management is presented, along with a quantification of estimation uncertainty.https://cassyni-user-files-prod.s3.amazonaws.com/47QSiwxsi2HqPp6hcViUQN https://cassyni.com/events/7Fj3pAVb5f2Jy3ksggV2km/seminar/qa https://cassyni.com/slides/outline/7Fj3pAVb5f2Jy3ksggV2km https://cassyni.com/events/7Fj3pAVb5f2Jy3ksggV2km/abstract https://cassyni-user-files-prod.s3.amazonaws.com/PaVnVw5x65mmQU76vKUAai https://cassyni.com/events/7Fj3pAVb5f2Jy3ksggV2km?videoPreview=1 Whole-field density measurements by digital image correlation, Identifying dominant flow features from very-sparse Lagrangian data: a multiscale recurrence network-based approachnohttps://cassyni.com/events/7Fj3pAVb5f2Jy3ksggV2km?videoPreview=12023-12-19T15:00:00+00:003559.2Experiments in FluidsA novel application of Synthetic Schlieren in a laboratory set-up yields a quantitative measurement of the density field of two-dimensional, stratified or homogeneous, transparent fluids in a laboratory set-up using a single camera. This application obtains local values of the density without the need for tomographic reconstruction algorithms that require images taken from different directions through the fluid nor does the application require regularization. This is achieved by placing the camera at a large oblique angle with respect to the experimental set-up. This step is motivated by a fallacy observed when applying ray tracing in a classical configuration, in which the camera's optical axis is perpendicular to the flat surface of a fluid container. The application is illustrated by the optical determination of static density fields of linearly and nonlinearly stratified fluids, as well as of multi-layered fluids. The application is validated by comparing with density profiles obtained from probe measurements of conductivity and temperature. Our application yields similar density and density gradient profiles as the probe while also providing a whole field measurement without disturbing the fluid, and allowing the determination of dynamical density fields. Realistic fluid flow problems often require that Lagrangian tracers are deployed in a sparse or very-sparse manner, such as for oceanic and atmospheric flows where large-scale motion needs characterisation. Data sparsity represents a significant issue in Lagrangian analysis, especially for data-driven methods that rely heavily on large datasets. We propose a multiscale spatial recurrence network (MSRN) methodology for characterising very-sparse Lagrangian data, which exploits individual tracks and a spatial recurrence criterion to identify the spatio-temporal complexity of tracer trajectories. The MSRN is an unsupervised modelling framework that does not require a priori parameter setting, and—through the quantification of persistent link activation at specific trajectory intervals—can reveal the presence of dominant looping scales in a variety of salient fluid flows. This new paradigm is shown to be successful for the study of Lagrangian tracers seeded in complex (realistic) flows, including unsteady and advection-dominated problems. This makes MSRNs an effective and versatile tool to characterise sensor trajectories in key problems such as environmental processes critical to understanding and mitigating climate change.https://cassyni-user-files-prod.s3.amazonaws.com/PaVnVw5x65mmQU76vKUAai https://cassyni.com/events/pbQJeNpFcwEaBWe5mVEmK/seminar/qa https://cassyni.com/slides/outline/pbQJeNpFcwEaBWe5mVEmK https://cassyni.com/events/pbQJeNpFcwEaBWe5mVEmK/abstract https://cassyni-user-files-prod.s3.amazonaws.com/PssT7aMWZfXJw6wMhjwpc6 https://cassyni.com/events/pbQJeNpFcwEaBWe5mVEmK?videoPreview=1 An overview of waves in random media with comparisons to periodicnohttps://cassyni.com/events/pbQJeNpFcwEaBWe5mVEmK?videoPreview=12023-11-14T14:00:00+00:003028.28MetaMATDescribing exactly how waves multiply scatter between a complex arrangement of particles is challenging. There exist accurate numerical methods, but they lack intuition, and can be slow for a large quantity of particles. To resolve this, we use theoretical methods to deduce dispersion equations, usually for an infinite media, which leads to a basis for the solution. The solution can then be completely determined with some boundary conditions or matching. This is true for periodic materials, homogeneous, and also holds true for waves in material with a random arrangement of particles (averaged over all configurations) for any frequency. In this talk, I will give an overview of results for waves in a random particulate, while making some light comparisons with periodic materials. There are many opportunities and applications of this theory in both developing new sensors and designing materials, which I will mention.https://cassyni-user-files-prod.s3.amazonaws.com/PssT7aMWZfXJw6wMhjwpc6 https://cassyni.com/events/9EKTzu5gqVF54m373eLyBK/seminar/qa https://cassyni.com/slides/outline/9EKTzu5gqVF54m373eLyBK https://cassyni.com/events/9EKTzu5gqVF54m373eLyBK/abstract https://cassyni-user-files-prod.s3.amazonaws.com/4QybrmyXa5wJzajjMaMNa2 https://cassyni.com/events/9EKTzu5gqVF54m373eLyBK?videoPreview=1 The internal logic and finite colimitsnohttps://cassyni.com/events/9EKTzu5gqVF54m373eLyBK?videoPreview=12023-11-29T15:00:00+00:003402.68Logica UniversalisWe describe how finite colimits can be described using the internal language, also known as the Mitchell-Benabou language, of a topos, provided the topos admits countably infinite colimits. This description is based on the set theoretic definitions of colimits and coequalizers, however the translation is not direct due to the differences between set theory and the internal language. These differences are described as internal versus external. Solutions to the hurdles which thus arise are given.https://cassyni-user-files-prod.s3.amazonaws.com/4QybrmyXa5wJzajjMaMNa2 https://cassyni.com/events/K7KB3CY521F84kjXqn3mws/seminar/qa https://cassyni.com/slides/outline/K7KB3CY521F84kjXqn3mws https://cassyni.com/events/K7KB3CY521F84kjXqn3mws/abstract https://cassyni-user-files-prod.s3.amazonaws.com/9eV9rqgqpiZfKiYbqYUFeW https://cassyni.com/events/K7KB3CY521F84kjXqn3mws?videoPreview=1 Mendel's closet: genetics, eugenics and the exceptions of sex in Edwardian Britainnohttps://cassyni.com/events/K7KB3CY521F84kjXqn3mws?videoPreview=12024-01-31T11:00:00+00:003680.76Royal Society PublishingThis article situates formative Mendelian and chromosomal precepts and rhetoric as an integral part of ‘reproductive’ physiology and the broader sexological terrain in Edwardian Britain. Alongside the discovery of ‘internal secretions’ (hormones), the discovery of the sex chromosomes, made around the same time as the rediscovery of Mendel's laws of heredity at the turn of the twentieth century, transformed the ways in which questions about sex determination and sex development were considered. Approaches were diverse as leading biologists including William Bateson, Leonard Doncaster, Reginald Crundall Punnett, Geoffrey Watkins Smith and their interlocutors negotiated the multiple, often conflicting, sociopolitical interpretations, uses and abuses that Mendelian approaches to sex were amenable to. Most contentiously, it was recognized that any credible model of sex biology had to account for all manner of sex phenomena, including parthenogenesis, intersexualities and transformations of sex, and that it was the variations of sex that best provided insights into the otherwise hidden mechanisms that shaped sex characteristics. Such a move, however, embroiled the new sexological genetics and the developing discipline of ‘reproductive’ physiology with vexed debates about feminism, homosexuality and eugenics. The article charts how the ensuing tensions played out across scholarly and popular platforms, including Britain's newspapers.https://cassyni-user-files-prod.s3.amazonaws.com/9eV9rqgqpiZfKiYbqYUFeW https://cassyni.com/slides/outline/H8cGPwtRejKpnbBdhWxa1s https://cassyni.com/events/H8cGPwtRejKpnbBdhWxa1s/abstract https://cassyni-user-files-prod.s3.amazonaws.com/RSxmyZcvBAApb5k2DebuGA https://cassyni.com/events/H8cGPwtRejKpnbBdhWxa1s?videoPreview=1 Sparse Nonlinear Dynamics Models with SINDy, Part 4: The Library of Candidate Nonlinearitiesnohttps://cassyni.com/events/H8cGPwtRejKpnbBdhWxa1s?videoPreview=12021-10-08T12:00:00+00:001636.64Brunton LabThis video discusses how to choose an effective library of candidate terms for the Sparse Identification of Nonlinear Dynamics (SINDy) algorithm. We discuss how to extend SINDy to include control variables and bifurcation parameters, as well as to include more general rational functions. We also discuss how to avoid the curse of dimensionality with the SVD, autoencoders, and the tensor train formulation. Finally, we show how to use physical symmetries to constrain the library. SLB acknowledges support from the National Science Foundation AI Institute in Dynamic Systems (grant number 2112085).https://cassyni-user-files-prod.s3.amazonaws.com/RSxmyZcvBAApb5k2DebuGA https://cassyni.com/slides/outline/VUvs1Z86EcsYbG2frszfdP https://cassyni.com/events/VUvs1Z86EcsYbG2frszfdP/abstract https://cassyni-user-files-prod.s3.amazonaws.com/2e8YriWMUQsxJwZGyoJNVC https://cassyni.com/events/VUvs1Z86EcsYbG2frszfdP?videoPreview=1 Aeroacoustics and Aerodynamics of quiet owl flightnohttps://cassyni.com/events/VUvs1Z86EcsYbG2frszfdP?videoPreview=12023-05-26T12:00:00+00:003141.36UK Fluids NetworkMany owl species rely on specialized plumage to mitigate their aerodynamic noise and achieve functionally-silent flight while hunting. One such plumage feature, a tattered arrangement of flexible trailing-edge feathers, is idealized as a semi-infinite poroelastic plate to model the effects that edge compliance and flow seepage have on the noise production. The associated acoustic scattering problem is solved to identify how the noise scales with the flight velocity, where special attention is paid to the limiting cases of rigid-porous and elastic-impermeable plate conditions. Results from this analysis identify new parameter spaces where the porous and/or elastic properties of a trailing edge may be tailored to diminish or effectively eliminate the edge scattering effect and may contribute to the owl hush-kit. In complement to the acoustic analysis, steady and unsteady aerodynamic models including wing porosity are formulated and solved in anticipation of the potential trade-off of aerodynamic performance and acoustic stealth. The aerodynamic analysis yields porous extensions of the classical unsteady aerodynamic functions and further indicates how porosity may be used as a passive gust rejection strategy.https://cassyni-user-files-prod.s3.amazonaws.com/2e8YriWMUQsxJwZGyoJNVC https://cassyni.com/events/2KA91SUgUziCUetvgs8qU9/seminar/qa https://cassyni.com/slides/outline/2KA91SUgUziCUetvgs8qU9 https://cassyni.com/events/2KA91SUgUziCUetvgs8qU9/abstract https://cassyni-user-files-prod.s3.amazonaws.com/8aDhF6z2hCBREiGimSwDta https://cassyni.com/events/2KA91SUgUziCUetvgs8qU9?videoPreview=1 Searching for the fountain of youth - use of PI3K inhibitors to extend life/health-spannohttps://cassyni.com/events/2KA91SUgUziCUetvgs8qU9?videoPreview=12023-04-18T04:00:00+00:003458.8The Auckland Bioengineering InstituteAdvancing age is a risk factor common to non-communicable diseases such as cardiovascular disease, neurological disease and cancer. As such, there has been considerable interest in understanding, and potentially preventing, the biological causes of ageing. Data from model organisms and some rodent studies shows that genetic modification of various parts of the insulin/IGF signalling pathway can extend lifespan, suggesting this may be a promising target for intervention. Here I will present some research we conducted looking at chronic pharmacological inhibition of the enzyme PI3K, common to both insulin and IGF signalling, and the effects of PI3K inhibition on lifespan, metabolic health and physical health through ageing. https://cassyni-user-files-prod.s3.amazonaws.com/8aDhF6z2hCBREiGimSwDta https://cassyni.com/slides/outline/DBRS2UiE94tfzvixJQNXQy https://cassyni.com/events/DBRS2UiE94tfzvixJQNXQy/abstract https://cassyni-user-files-prod.s3.amazonaws.com/LYwbcgRWLYbnnfgC7jazbY https://cassyni.com/events/DBRS2UiE94tfzvixJQNXQy?videoPreview=1 Anthromes, CO2 and Terrestrial Carbon – Session 7: CO2-fertilization and human land-use contributions to future terrestrial carbon storagenohttps://cassyni.com/events/DBRS2UiE94tfzvixJQNXQy?videoPreview=12023-03-29T20:00:00+00:006932.44The New Phytologist Foundation4.00 – 4.20: What is the mitigation potential of improved land-use, and how will it respond to future climate change? , Stephanie Roe 4.20 – 4.40: Agroforestry as a natural climate solution, Susan Cook-Patton 4.40 – 5.00: Global Carbon Dioxide Removal Potential of Trees in Agriculture , Vivian Griffey 5.00 – 5.20: Effect of land use and land cover change and CO2 fertilization on the future carbon sink for the conterminous U.S, Benjamin Felzer 5.20 – 5.40: What will happen to the terrestrial carbon sink once we reach net zero?, Charlie Kovenhttps://cassyni-user-files-prod.s3.amazonaws.com/LYwbcgRWLYbnnfgC7jazbY https://cassyni.com/events/S2PdgmbRAQzuZZj7DDci6Z/seminar/qa https://cassyni.com/slides/outline/S2PdgmbRAQzuZZj7DDci6Z https://cassyni.com/events/S2PdgmbRAQzuZZj7DDci6Z/abstract https://cassyni-user-files-prod.s3.amazonaws.com/NtvSJZQnB844HAjeb7xANa https://cassyni.com/events/S2PdgmbRAQzuZZj7DDci6Z?videoPreview=1 The Equity in Newborn Drug Screening (ENDS) Study: How Family Medicine Teams Can Mobilize for Change with Antiracist Methods and Practicesnohttps://cassyni.com/events/S2PdgmbRAQzuZZj7DDci6Z?videoPreview=12024-05-30T20:00:00+00:004107.72Family MedicineLearning Objectives:   - Describe at least two social justice frameworks, including community engagement and antiracism, that can be applied in healthcare research and clinical care to address real-world problems and promote health equity.  - Identify at least three ways in which family physicians and learners can meaningfully contribute to antiracist efforts to improve research, education, and clinical care.  - Describe the potential harms that may result from newborn drug screening on families and ways to mitigate this harm through clinical practice and healthcare policy. https://cassyni-user-files-prod.s3.amazonaws.com/NtvSJZQnB844HAjeb7xANa https://cassyni.com/slides/outline/UVdevBq3MhmPvWCfkuXLpV https://cassyni.com/events/UVdevBq3MhmPvWCfkuXLpV/abstract https://cassyni-user-files-prod.s3.amazonaws.com/9B79nBYBx7JtEeqxeP2Zti https://cassyni.com/events/UVdevBq3MhmPvWCfkuXLpV?videoPreview=1 Analytical solutions for Bloch waves in resonant phononic crystalsnohttps://cassyni.com/events/UVdevBq3MhmPvWCfkuXLpV?videoPreview=12024-03-19T14:00:00+00:003730.04MetaMATI will discuss the canonical problem of wave scattering by arrays of Neumann inclusions. Firstly, we consider the wavefield to be governed by the Helmholtz equation. We apply the method of matched asymptotic expansions to show how small scatterers can be modelled as singular perturbations to the free space. Analytical expressions then follow in terms of singular Green’s functions (and their derivatives), from which we can construct an eigenvalue problem to consider Floquet-Bloch waves, or we can consider scattering problems as an extension to Foldy’s method. The methods presented allow for efficient, rapid, and accurate computations. These methods will then be applied in an elastic setting, to consider waves propagating through an elastic plate, whose surface is patterned by periodic arrays of elastic beams. Our methodology is versatile and allows us to solve a range of problems regarding arrangements of multiple beams per primitive cell, over Bragg to deep-subwavelength scales. We cross-verify against finite element numerical simulations to gain further confidence in our approach. The accuracy and flexibility of our solutions are demonstrated by engineering topologically non-trivial states, from primitive cells with broken spatial symmetries, following the phononic analogue of the Quantum Valley Hall Effect. These topologically non-trivial states exist near flexural resonances of the constituent beams of the phononic crystal and hence can be tuned into a deep-subwavelength regime.https://cassyni-user-files-prod.s3.amazonaws.com/9B79nBYBx7JtEeqxeP2Zti https://cassyni.com/slides/outline/CC8Dw7RBG9nXLAtxCRuCc5 https://cassyni.com/events/CC8Dw7RBG9nXLAtxCRuCc5/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Y9qG7To8KHNPQcuw5fqrSr https://cassyni.com/events/CC8Dw7RBG9nXLAtxCRuCc5?videoPreview=1 Concurrent multi-scale modeling of granular materials: Role of coarse-graining in FEM-DEM couplingnohttps://cassyni.com/events/CC8Dw7RBG9nXLAtxCRuCc5?videoPreview=12023-07-24T12:00:00+00:002084.72Cassyni SeminarsThe finite element method (FEM) and the discrete element method (DEM) are two commonly used techniques in modeling different types of materials. FEM is used for materials that behave like a continuous substance, while DEM is used for materials that can be seen as individual particles. Sometimes, it's necessary to combine these two methods to get a more accurate representation of the granular material's behavior. This is typically done by directly connecting the individual particles in DEM with the larger elements in FEM. A technique called coarse-graining (CG) is used to bridge the gap between these two methods. It takes the data from the individual particles and turns it into smooth, continuous fields that follow the laws of continuous materials. By choosing a specific scale, the coarse-grained fields are then mixed together and applied to the FEM model. In this research, we explore a new way of combining FEM and DEM, both for surfaces and volumes. When dealing with surfaces, we convert the discrete contact forces between particles and surfaces into a smooth, continuous traction field that is then applied to the FEM model. For volumes, we enhance the homogenization process with additional functions to connect the discrete particles, their coarse-grained fields, and the finite element formulation. This new approach offers better accuracy and symmetry in surface coupling, reducing the energy produced during the combination of FEM and DEM, and for volume coupling, it significantly decreases numerical dissipation, especially when the load applied contains high-frequency components. This technique has the potential to be expanded beyond the current examples. It could be applied to different types of materials and governing equations, allowing for more advanced multi-scale and multi-physical modeling methods.https://cassyni-user-files-prod.s3.amazonaws.com/Y9qG7To8KHNPQcuw5fqrSr https://cassyni.com/events/5HAFk4RNjBjeRaGpw6hND3/seminar/qa https://cassyni.com/slides/outline/5HAFk4RNjBjeRaGpw6hND3 https://cassyni.com/events/5HAFk4RNjBjeRaGpw6hND3/abstract https://cassyni-user-files-prod.s3.amazonaws.com/4cVMN8twPx6rjvhU58kMQr https://cassyni.com/events/5HAFk4RNjBjeRaGpw6hND3?videoPreview=1 Revisiting the computation of the critical points of the Keplerian distance, Mars orientation and rotation anglesnohttps://cassyni.com/events/5HAFk4RNjBjeRaGpw6hND3?videoPreview=12024-01-26T14:00:00+00:004393.56Celestial Mechanics and Dynamical AstronomyAuthors: Giovanni F. Gronchi, Giulio Baù, Clara Grassi We consider the Keplerian distance d in the case of two elliptic orbits, i.e., the distance between one point on the first ellipse and one point on the second one, assuming they have a common focus. The absolute minimum d_min of this function, called MOID or orbit distance in the literature, is relevant to detect possible impacts between two objects following approximately these elliptic trajectories. We revisit and compare two different approaches to compute the critical points of d^2, where we squared the distance d to include crossing points among the critical ones. One approach uses trigonometric polynomials, and the other uses ordinary polynomials. A new way to test the reliability of the computation of d_min is introduced, based on optimal estimates that can be found in the literature. The planar case is also discussed: in this case, we present an estimate for the maximal number of critical points of d^2, together with a conjecture supported by numerical tests. Authors: Marie Yseboodt, Rose-Marie Baland, Sébastien Le Maistre The rotation and orientation of Mars is commonly described using two different sets of angles, namely (1) the Euler angles with respect to the Mars orbit plane and (2) the right ascension, declination, and prime meridian location angles with respect to the Earth equator at J2000 (as adopted by the IAU). We propose a formulation for both these sets of angles, which consists of the sum of a second degree polynomial and of periodic and Poisson series. Such a formulation is shown here to enable accurate (and physically sound) transformation from one set of angles to the other. The transformation formulas are provided and discussed in this paper. In particular, we point that the quadratic and Poisson terms are key ingredients to reach a transformation precision of 0.1 mas, even 30 years away from the reference epoch of the rotation model (e.g., J2000). Such a precision is required to accurately determine the smaller and smaller geophysical signals observed in the high-accuracy data acquired from the surface of Mars. In addition, we present good practices to build an accurate Martian rotation model over a long time span (30 years around J2000) or over a shorter one (e.g., lifetime of a space mission). We recommend to consider the J2000 mean orbit of Mars as the reference plane for Euler angles. An accurate rotation model should make use of up-to-date models for the rigid (this study) and liquid (Le Maistre et al., 2023) nutations, relativistic corrections in rotation (Baland et al. 2023), and polar motion induced by the external torque (this study). Our transformation model and recommendations can be used to define the future IAU solution for the rotation and orientation of Mars using right ascension, declination, and prime meridian location. In particular, thanks to its quadratic terms, our transformation model does not introduce arbitrary and non-physical terms of very long period and large amplitudes, thus providing unbiased values of the rates and epoch values of the angles.https://cassyni-user-files-prod.s3.amazonaws.com/4cVMN8twPx6rjvhU58kMQr https://cassyni.com/events/VyVbiMDxTzeWVjQxTyeGLD/seminar/qa https://cassyni.com/slides/outline/VyVbiMDxTzeWVjQxTyeGLD https://cassyni.com/events/VyVbiMDxTzeWVjQxTyeGLD/abstract https://cassyni-user-files-prod.s3.amazonaws.com/LiedorLpWr3uwEUbjXLT4r https://cassyni.com/events/VyVbiMDxTzeWVjQxTyeGLD?videoPreview=1 Nanoscale 3D Printingnohttps://cassyni.com/events/VyVbiMDxTzeWVjQxTyeGLD?videoPreview=12023-05-25T00:15:00+00:003433.32The MacDiarmid Institute for Advanced Materials and NanotechnologyMicro- and nanofabrication, as used for integrated circuit manufacturing, consists predominantly of a large number of repetitive 2D processing steps. Modern etching technologies have enabled what essentially are 2.5D structures, but large-area free-form 3D patterning at the nanoscale has been out of reach. This paradigm is now increasingly being challenged by advances in 3D printing technology, with two-photon polymerization (2PP) quickly becoming the new standard for micro- and nanofabrication. As opposed to stereolithography, where a UV laser scans the surface of a photosensitive material to produce a 2D pattern of polymerized material, 2PP polymerizes a material along the trace of the laser focus moving through a resin, thus enabling fabrication of fully 3D patterns. This difference in pattern generation is achieved by initiation of 2PP within the small volume of the material via precise focusing of NIR femtosecond laser pulses. As such, 2PP achieves higher resolution then stereolithography and is not limited to the traditional layer-by-layer approach. In 2019, the University of Canterbury Nanofabrication Laboratory, housed in the Electrical and Computer Engineering Department, installed a commercial 2PP system in form of a Nanoscribe Photonic Professional GT2 (PPGT2). In this seminar, we will discuss the physics behind 2PP, introduce the PPGT2 system and operation, and showcase a selection of application examples [1,2], both in form of general micro- and nano structures, as well as diffractive optical elements.https://cassyni-user-files-prod.s3.amazonaws.com/LiedorLpWr3uwEUbjXLT4r https://cassyni.com/slides/outline/YSjcwmTafHQzrftX1fYu49 https://cassyni.com/events/YSjcwmTafHQzrftX1fYu49/abstract https://cassyni-user-files-prod.s3.amazonaws.com/AVdYrHA7KsuUg5pDHKbSW https://cassyni.com/events/YSjcwmTafHQzrftX1fYu49?videoPreview=1 The challenges & progress in Human Powered Flightnohttps://cassyni.com/events/YSjcwmTafHQzrftX1fYu49?videoPreview=12023-05-23T04:00:00+00:005069.32The Auckland Bioengineering InstituteWhat does it take to fly an HPA: the history of the sport and where you can do it: the engineering challenge and the human factors to overcome. What it is like and how much energy it takes to fly, the previous research and the best approaches and common materials to build an HPA. What can go wrong in flights, and how much control you have and the aircrafts' present limits. The events in Human Powered Flying, and the 4 outstanding prizes in the sport yet to be won (total Prizes in the UK add up to $270,000). What does success result in and the real world application of this technology in High Altitude Autonomous aircraft (eg Airbus Zephyr).https://cassyni-user-files-prod.s3.amazonaws.com/AVdYrHA7KsuUg5pDHKbSW https://cassyni.com/events/4Hs3eh8KrGdVkpSpq8E3Q9/seminar/qa https://cassyni.com/slides/outline/4Hs3eh8KrGdVkpSpq8E3Q9 https://cassyni.com/events/4Hs3eh8KrGdVkpSpq8E3Q9/abstract https://cassyni-user-files-prod.s3.amazonaws.com/4SWRWn2PSAfaMQFFQBfDGS https://cassyni.com/events/4Hs3eh8KrGdVkpSpq8E3Q9?videoPreview=1 Conservation Biogeography of Australasian Marsupialsnohttps://cassyni.com/events/4Hs3eh8KrGdVkpSpq8E3Q9?videoPreview=12024-05-16T09:00:00+00:002091.04Cambridge PrismsThe diverse and distinctive Australasian marsupial fauna has experienced considerable loss over the last 200 years. Seventeen of the 176 Australian marsupial species have become extinct in this period (~10%), far higher than the global average (1.4%). Many extinct Australian marsupials were formerly abundant and widespread. About 40% of Australian marsupials are now threatened. The pattern of decline in Australian marsupials is broadly similar to that of Australia’s native rodents- invasive mammalian predators and land use that facilitates them are the major problems. Knowledge of the marsupial faunas of Papua New Guinea and Indonesia is relatively poor. Both regions have high endemism. There are 96 species of marsupials on the main island of New Guinea and surrounding small islands, and 15 species in Wallacea (the islands of Indonesia and East Timor east of Wallace’s line) including five shared with New Guinea. Although none are listed as Extinct, two Critically Endangered marsupials are flagged “possibly extinct.” Most threatened New Guinean and Wallacean species follow the globally typical pattern of high vulnerability in island endemics and small-range mammals with specialist habitats. The major threats to marsupials of New Guinea and Indonesia are habitat loss, hunting, and low levels of awareness and investment in conservation and research. Many Australasian marsupial species – particularly mountain-top endemics are increasingly threatened by climate change. https://cassyni-user-files-prod.s3.amazonaws.com/4SWRWn2PSAfaMQFFQBfDGS https://cassyni.com/slides/outline/TWFaUvzLGhsyTaBB1BquL1 https://cassyni.com/events/TWFaUvzLGhsyTaBB1BquL1/abstract https://cassyni-user-files-prod.s3.amazonaws.com/RcPvWYazZydnVfWwcUcyb4 https://cassyni.com/events/TWFaUvzLGhsyTaBB1BquL1?videoPreview=1 Session 6nohttps://cassyni.com/events/TWFaUvzLGhsyTaBB1BquL1?videoPreview=12023-07-04T01:00:00+00:004704.88New Phytologist Foundation Anyone who has ever isolated intact chloroplasts can tell that they are fickle organelles that do not last long after isolation. Sacoglossan sea slugs do not share this experience, as some of them can isolate chloroplasts from their prey algae and incorporate them intracellularly as new foreign organelles – kleptoplasts. Separated from the algal nucleus and in the face of light induced damage, kleptoplasts challenge the paradigms of photosynthesis by remaining active inside the slugs for months. There is currently no definitive explanation to this phenomenon known to exist in several species of sacoglossans that incorporate the chloroplasts from different algal species. We measured the kinetics of photoinhibition, the irreversible damage to photosystem II (PSII), under high light in multiple combinations of photosynthetic slugs and their prey algae to understand how much the resilience against photoinhibition contributes to the overall longevity of the kleptoplasts. Out of all the tested slugs, Elysia timida is the only species that eats only one alga, Acetabularia acetabulum, and it was also by far the best species in terms of protecting kleptoplasts from photoinhibition. The molecular mechanisms behind the remarkable photoprotection in E. timida are currently under investigation. How topological and geometrical cell properties instruct cells behavior is a fundamental question in developmental biology. Despite the intrinsic relationship between cell expansion and cell differentiation, how cell expansion induces cell differentiation remains unknown. Here, by using genetic and molecular approaches, and by taking advantage of high-throughput techniques, we demonstrated that changes of the cell wall mechanical properties are translated into variations of the cell state, thus determining if a cell will divide or differentiate. Stiffer cell wall promotes cell division while a more elastic cell wall induces cell differentiation. To understand how these different cell wall mechanical properties are translated in different cell activities, we performed a transcriptome analysis, where cell wall mechanical properties are altered in a time-controlled and zone-specific manner. These analyses established the foundation for identifying the genes that respond to these changes and subsequently influence cell activity. This represents one of the first evidences that cell wall mechanical properties can instruct cell fate. Seeds are a recent evolutionary innovation that arose once from an ancestral spore-based reproductive mechanism that is still present in living seedless plant groups (e.g. mosses, liverworts and ferns). How this dramatic transition to seed-based reproduction occurred is currently unknown. SPOROCYTELESS/NOZZLE (SPL/NZZ) is a crucial regulator of seed development in Arabidopsis, but related genes (homologs) also exist in plants that do not make seeds. Identifying the functions of SPL/NZZ genes in seedless plants may therefore help to explain how seeds first evolved. Here we use a model seedless plant, the fern Ceratopteris richardii, to investigate the function of such SPL homologs. We have identified three SPL-like genes in Ceratopteris richardii. Phylogenetic analysis places two of these genes within the Arabidopsis SPL/NZZ clade, providing evidence that SPL function may predate the evolutionary origin of the seed. We further compare the expression of these three homologs in different reproductive and non-reproductive tissue stages. We demonstrate that these homologs have different patterns and levels of expression across tissue types, suggesting that there are functional differences between them. This work provides the foundation upon which to begin further investigation into a potential role for SPL-like genes during the evolution of the seed.https://cassyni-user-files-prod.s3.amazonaws.com/RcPvWYazZydnVfWwcUcyb4 https://cassyni.com/events/KbzQCWhUrpiwtDj3dtAk85/seminar/qa https://cassyni.com/slides/outline/KbzQCWhUrpiwtDj3dtAk85 https://cassyni.com/events/KbzQCWhUrpiwtDj3dtAk85/abstract https://cassyni-user-files-prod.s3.amazonaws.com/JQ2dkcCivhRzSffzLCXLeJ https://cassyni.com/events/KbzQCWhUrpiwtDj3dtAk85?videoPreview=1 Exemplar Project 4: Automated workflows for breast cancer diagnosis and treatmentnohttps://cassyni.com/events/KbzQCWhUrpiwtDj3dtAk85?videoPreview=12024-10-01T23:00:00+00:003022.92Auckland Bioengineering InstituteBreast cancer represents a significant public health issue with approximately 2.3 million women worldwide being diagnosed with breast cancer each year. Early detection and treatment is key to improving outcomes. However, this is challenging due to the significant shape changes the breast undergoes during clinical interventions, which make localising tumours difficult. Our aim is to integrate state-of-the-art image processing techniques, personalised 3D biomechanical modelling, and population-based statistical analyses to help address clinical challenges in the interpretation of medical images to improve diagnosis and treatment of breast cancer. We will describe our latest efforts towards developing automated workflows to predict breast shape under different loading conditions to pinpoint the locations of suspected tumours during breast cancer diagnosis and treatment procedures. This includes: application of machine learning algorithms to automatically segment the breast and its internal tissues from diagnostic medical images; generation of 3D personalised and anatomically accurate models of the torso and upper limbs and the skeleton from segmented image data using a combination of nonlinear geometric fitting and statistical shape analysis techniques; simulation of large deformation mechanics to predict shape changes that occur when the breast is repositioned; and the development of augmented reality platform to visualise simulated tumour positions directly on patients during clinical procedures. Studies using MR images from breast cancer patients are underway in collaboration with breast radiologists at Auckland City Hospital to assess the efficacy of these technologies in the clinical setting. We will describe how the 12 Labours project is providing infrastructure, resources, and guidelines to supports these developments. This research has the potential to lead to technological advancements in the breast cancer imaging field, which could translate into better health outcomes for women, and improve breast care practices world-wide.https://cassyni-user-files-prod.s3.amazonaws.com/JQ2dkcCivhRzSffzLCXLeJ https://cassyni.com/events/8Ey1gGks9rH6gz8g5tFbdo/seminar/qa https://cassyni.com/slides/outline/8Ey1gGks9rH6gz8g5tFbdo https://cassyni.com/events/8Ey1gGks9rH6gz8g5tFbdo/abstract https://cassyni-user-files-prod.s3.amazonaws.com/9M8qYwway7RMJChzdoQrVk https://cassyni.com/events/8Ey1gGks9rH6gz8g5tFbdo?videoPreview=1 The role of microbial barriers as efficient wastewater treatment technologynohttps://cassyni.com/events/8Ey1gGks9rH6gz8g5tFbdo?videoPreview=12023-11-14T11:00:00+00:004754.52ElsevierWastewater contains a wide suite of microbial and chemical contaminants. However, not all microorganisms in wastewater are bad. They can be a source of inoculum which we can then tap into to assemble microbial barriers within biotechnologies. These microbial barriers can aid in efficient wastewater treatment. In this seminar, we discuss the role of microbial barriers in removing antibiotic resistance genes and organic micropollutants from wastewater. With the help of microbial barriers in bioreactors, wastewater can be converted into high-quality reclaimed water to meet the UN’s Sustainable Development Goal 6 (SDG6) of providing clean water and sanitation for all and to allow sustainable cities and communities to develop (SDG11). The reclaimed water can also be used for food (SDG2) and energy production (SDG7). https://cassyni-user-files-prod.s3.amazonaws.com/9M8qYwway7RMJChzdoQrVk https://cassyni.com/events/2oqNAke6KpC2J7tSUyFoeM/seminar/qa https://cassyni.com/slides/outline/2oqNAke6KpC2J7tSUyFoeM https://cassyni.com/events/2oqNAke6KpC2J7tSUyFoeM/abstract https://cassyni-user-files-prod.s3.amazonaws.com/J67EmAo83wgEEoo6SZHk1t https://cassyni.com/events/2oqNAke6KpC2J7tSUyFoeM?videoPreview=1 Free surface cuspsnohttps://cassyni.com/events/2oqNAke6KpC2J7tSUyFoeM?videoPreview=12023-09-27T13:00:00+00:003719.08Journal of Engineering MathematicsCusp shapes are widely observed in nature, most famously as the bright caustic lines on the inside of a coffee cup. This can be understood from the fact that a cusp arises from the smooth deformation of a parameterized curve. Remarkably, the same generic cusp can be formed on the surface of a viscous fluid with surface tension, as demonstrated by Jeong and Moffatt [1], using complex mapping techniques. However, his observation is limited to very specific and idealized geometries. Here we demonstrate that cusps are indeed local solutions to the Stokes equation with surface tension, regardless.https://cassyni-user-files-prod.s3.amazonaws.com/J67EmAo83wgEEoo6SZHk1t https://cassyni.com/slides/outline/Dg6fBnsdytNVpPiU6WVVbB https://cassyni.com/events/Dg6fBnsdytNVpPiU6WVVbB/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Hi2FmcEbYemrL6hN94aidU https://cassyni.com/events/Dg6fBnsdytNVpPiU6WVVbB?videoPreview=1 Session 5nohttps://cassyni.com/events/Dg6fBnsdytNVpPiU6WVVbB?videoPreview=12023-07-03T06:00:00+00:005571.04New Phytologist Foundation Plant genomes are characterized by large and complex gene families that often result in similar and partially overlapping functions. This genetic redundancy severely hampers current efforts to uncover novel phenotypes, delaying basic genetic research and breeding programs. To address the problem of masked phenotypic variation due to functional redundancy, we developed and validated Multi-Knock, a novel genetic approach in plants that combines forward-genetics with dynamically targeted genome-scale CRISPR/Cas9 tools. A total of 59,129 multi-targeted sgRNAs, divided into 10 functional sub-libraries targeting 16,152 genes in Arabidopsis, were designed, synthesized, and cloned into a genome-editing intronized Cas9 vector. From this collection, 5,635 sgRNAs targeting 1,123 of the 1,327 transporters (TRP) in Arabidopsis were cloned into four different Cas9 vectors generating independent CRISPR libraries, wherein each sgRNA was designed to target closely related homologues within sub-clades in transporter families. A proof of concept forward-genetic screen using over 3,500 CRISPR lines targeting the plant transportome recovered multiple known phenotypes in Arabidopsis, demonstrating the validity of the approach. Moreover, our screen allowed us to uncover novel transporters whose function has been hidden due to genetic redundancy. Specifically, we identified a homologous subfamily of three previously unstudied genes with partially overlapping function, PUP7, PUP21, and PUP8. We discovered that while all three proteins biochemically function as cytokinin transporters, PUP8 localizes to the plasma membrane, while PUP7 and PUP21 are localized to the tonoplast. We show that these proteins regulate meristem size, phyllotaxis, and plant growth, revealing complex redundant activity within this sub-family and providing a demonstration of the power of the Multi-Knock approach to discover new biological functions. Discovering molecular mechanisms that govern traits that boost crop productivity under environmental stress, including pathogen attack is an urgent need. Gene co-expression network (GCN) analysis has been widely used to reveal hub genes and key pathways from gene expression datasets. To understand the molecular mechanism of disease progression in papaya dieback disease (PDD) and prioritise hub genes for increasing antioxidant content in pigmented rice, we performed GCN analysis from RNA-seq datasets. A modified Markov Cluster (MCL) algorithm was used to identify co-expression modules and hub genes within these modules in the rice and papaya. The papaya GCN consisted of 53 modules that defined the papaya-pathogen (Erwinia mallotivora) interaction network. The modules revealed not only classical disease resistance-related pathways, such as pattern recognition receptors (PRR) and pathogenesis-related (PR) genes but also new molecular regulators that could be prioritised for further validation and papaya breeding programme. The pigmented rice GCN identified three established functional modules related to flavonoid and terpenoid biosynthesis as well as transcriptional regulators that modulate these pathways in the rice seed. The rice and papaya breeding programmes in Malaysia will use the information generated here as a foundation for marker-assisted breeding or gene editing, for improving crop productivity. Plastid primary endosymbiosis has occurred twice, once ~1.5 Bya in the Archaeplastida ancestor and once ~120 Mya in the Paulinella (Rhizaria) lineage. Both events precipitated massive evolutionary changes, including the recruitment and activation of genes that are horizontally acquired, redeployment of existing genes and pathways in novel contexts, and the evolution of mechanisms for controlling the new endosymbiont by the host. Whereas significant steps have been made into understanding organelle evolution using the Archaeplastida model, its ancient provenance limits our ability to investigate the factors governing the early stages of endosymbiosis. Our work using multi-omics analysis of the recently evolved photosynthetic Paulinella lineage, has provided novel insights into the evolutionary strategies that facilitated the transition of a eukaryotic organisms from a heterotrophic to a photosynthetic lifestyle. These insights include the role of retrotransposition in the integration of endosymbiont-derived genes and the evolution of control of endosymbiont pathways by the host, results which have led to testable hypotheses about the forces that shape the genome evolution of both the host and endosymbiont after primary endosymbiosis. These results not only open new avenues for studying Archaeplastida evolution, but, in ongoing work, allow the exploration and optimization of photosynthesis in traditional systems. Synthetic gene circuits can enable new cellular behaviours by integrating multiple input signals into customisable genetic programs. However, gene circuit development in plants has been limited by a lack of orthogonal and modular parts required for their construction. Here, we present the first implementation of reversible CRISPRi-based gene circuits in plants. First, we created a toolkit of engineered repressible promoters of different strengths and used them as integrators for the construction of NOT and NOR gates in Arabidopsis thaliana. Next, we determined the optimal processing system to express sgRNAs from RNA Pol II promoters to introduce NOR gate programmability for interfacing with host regulatory sequences. Finally, we layered multiple NOR gates together to create OR, NIMPLY, and AND logic functions and tested NOR gate activity in Physcomitrium patens to demonstrate cross-species utility. Our CRISPRi circuits are orthogonal, compact, reversible, programmable, and modular, providing a new platform for sophisticated spatio-temporal control of gene expression in plants. Potatoes represent the most important non-cereal source of calories for human consumption reaching a production of 376 million metric tons in 2021. Even though many of the tuber inducing pathways have been identified, the process by which stolons, a specialized underground stem, swells to become the tuber remains unknown. To understand the cellular processes behind this we first performed transverse sections of potato stolons in different stages of tuberization and looked for patterns of cellular proliferation. To identify the gene regulatory network behind this, we performed single cell RNA-seq of induced and un-induced in vitro tubers. This was the first time something like this was attempted in a storage organ. We validated the identity of our cluster analysis through in-situ assays of in-vitro and stolon derived tubers. Our results show a new kind of cellular identity, enriched in tuber identity and starch accumulation genes.https://cassyni-user-files-prod.s3.amazonaws.com/Hi2FmcEbYemrL6hN94aidU https://cassyni.com/events/ADZRs1LxugVrnhQuSr7Y4M/abstract https://cassyni-user-files-prod.s3.amazonaws.com/M9YpGpPCGuU77wDyyeURpJ https://cassyni.com/slides/outline/CgoT6Rab6yGM9dtTzY2AnH https://cassyni.com/events/CgoT6Rab6yGM9dtTzY2AnH/abstract https://cassyni-user-files-prod.s3.amazonaws.com/7wsBRkWjMnqX2bSUWWiub4 https://cassyni.com/events/CgoT6Rab6yGM9dtTzY2AnH?videoPreview=1 Normal forms for Laplace-like resonancesnohttps://cassyni.com/events/CgoT6Rab6yGM9dtTzY2AnH?videoPreview=12022-09-07T16:45:01+00:00978.92Celestial Mechanics and Dynamical AstronomyWe describe the generalisation of the de Sitter equilibria in multi-resonant 1+3 body systems. The analysis of stability provides hints for the structure of multi-resonant planetary systems.https://cassyni-user-files-prod.s3.amazonaws.com/7wsBRkWjMnqX2bSUWWiub4 https://cassyni.com/slides/outline/PZ6NE6L2AQNYpgzjrUodau https://cassyni.com/events/PZ6NE6L2AQNYpgzjrUodau/abstract https://cassyni-user-files-prod.s3.amazonaws.com/WtCxtBZfnRvrhgVqmBqz5L https://cassyni.com/events/PZ6NE6L2AQNYpgzjrUodau?videoPreview=1 FuturePub — San Francisconohttps://cassyni.com/events/PZ6NE6L2AQNYpgzjrUodau?videoPreview=12023-07-13T19:00:00+00:005786.88On Thursday, July 13th 2023, Digital Science headed to the picturesque Presidio in San Francisco to host our popular #FuturePub event. We’ve run over a dozen of these events to date – mainly in London – and this was our second in the US and first on the West Coast. For those new to FuturePub, the evenings are designed to be fun and informal – like meeting up for drinks with friends after work and at the same time giving people the opportunity to showcase the new and exciting things they’ve been working on in science and publishing tech. This one was a little more hectic than usual: a number of us from Digital Science were in San Francisco for Sci Foo, a pretty unique unconference being held that weekend at Google X. And because we like a challenge, we decided, at rather short notice, to host FuturePub the night before. Do or do not, as they say – so we did! Of course, thanks to many late-night phone calls with Jocelyn from the excellent venue hire team at the Letterman Digital Arts Center, home of LucasFilm and Industrial Light & Magic, it all worked out beautifully. It was a fun, informal gathering at a great venue, with lots of conversation, smiles and some very exclusive Skywalker Ranch food and drink, because apparently we’re fancy on the West Coast! We hope you enjoy the talks!https://cassyni-user-files-prod.s3.amazonaws.com/WtCxtBZfnRvrhgVqmBqz5L https://cassyni.com/slides/outline/WUApsfPNJp8LKVzKDvNZjb https://cassyni.com/events/WUApsfPNJp8LKVzKDvNZjb/abstract https://cassyni-user-files-prod.s3.amazonaws.com/GQsYQz5kW4Lx4hT5Zidtht https://cassyni.com/events/WUApsfPNJp8LKVzKDvNZjb?videoPreview=1 The role of force networks in granular materialsnohttps://cassyni.com/events/WUApsfPNJp8LKVzKDvNZjb?videoPreview=12021-05-12T12:00:00+00:005036.2Granular MatterGranular materials are inherently heterogeneous, and continuum models of properties such as rigidity and sound speed often fail to quantitatively capture their dynamics. One likely reason for these difficulties is that internal stresses are transmitted via a chain-like network of strong forces, introducing a secondary, meso-scale structure to the system. In my talk, I will describe several experiments on two-dimensional photoelastic granular materials which bridge particle-scale, meso-scale, and continuum-scale approaches. These experiments allow us to both investigate the statistical ensembles from which force networks are drawn, as well as probe their effects on mechanical properties such as sound transmission, rigidity, and rheology.https://cassyni-user-files-prod.s3.amazonaws.com/GQsYQz5kW4Lx4hT5Zidtht https://cassyni.com/slides/outline/8jeEqavGzfkvWki2qpyu3B https://cassyni.com/events/8jeEqavGzfkvWki2qpyu3B/abstract https://cassyni-user-files-prod.s3.amazonaws.com/57464vzodKsjJ2xGazGKrv https://cassyni.com/events/8jeEqavGzfkvWki2qpyu3B?videoPreview=1 The vivid science of visual quality assessment & the emerging field of cognitive computingnohttps://cassyni.com/events/8jeEqavGzfkvWki2qpyu3B?videoPreview=12021-04-08T12:30:00+00:003873.28Journal on Image and Video ProcessingNo abstracthttps://cassyni-user-files-prod.s3.amazonaws.com/57464vzodKsjJ2xGazGKrv https://cassyni.com/events/AiEf2KWNkVygcTzGCnqqTj/seminar/qa https://cassyni.com/slides/outline/AiEf2KWNkVygcTzGCnqqTj https://cassyni.com/events/AiEf2KWNkVygcTzGCnqqTj/abstract https://cassyni-user-files-prod.s3.amazonaws.com/7J36Yyk9cW7WyFovuTC1xJ https://cassyni.com/events/AiEf2KWNkVygcTzGCnqqTj?videoPreview=1 The future of governing equationsnohttps://cassyni.com/events/AiEf2KWNkVygcTzGCnqqTj?videoPreview=12023-10-25T15:00:00+00:003762.68Department of AeronauticsA major challenge in the study of dynamical systems is that of model discovery: turning data into reduced order models that are not just predictive, but provide insight into the nature of the underlying dynamical system that generated the data. We introduce a number of data-driven strategies for discovering nonlinear multiscale dynamical systems and their embeddings from data. We consider two canonical cases: (i) systems for which we have full measurements of the governing variables, and (ii) systems for which we have incomplete measurements. For systems with full state measurements, we show that the recent sparse identification of nonlinear dynamical systems (SINDy) method can discover governing equations with relatively little data and introduce a sampling method that allows SINDy to scale efficiently to problems with multiple time scales, noise and parametric dependencies. For systems with incomplete observations, we show that the Hankel alternative view of Koopman (HAVOK) method, based on time-delay embedding coordinates and the dynamic mode decomposition, can be used to obtain a linear models and Koopman invariant measurement systems that nearly perfectly captures the dynamics of nonlinear quasiperiodic systems. Neural networks are used in targeted ways to aid in the model reduction process. Together, these approaches provide a suite of mathematical strategies for reducing the data required to discover and model nonlinear multiscale systems.https://cassyni-user-files-prod.s3.amazonaws.com/7J36Yyk9cW7WyFovuTC1xJ https://cassyni.com/slides/outline/MaXa9zFoow5tHDWh6u1y3B https://cassyni.com/events/MaXa9zFoow5tHDWh6u1y3B/abstract https://cassyni-user-files-prod.s3.amazonaws.com/SE41ZG2q3njDLmNayDfXup https://cassyni.com/events/MaXa9zFoow5tHDWh6u1y3B?videoPreview=1 Immunoreactivity to Campylobacter jejuni in Guillain-Barré syndrome and correlation with ganglioside autoantibody profile: case-control studynohttps://cassyni.com/events/MaXa9zFoow5tHDWh6u1y3B?videoPreview=12021-08-11T11:30:00+00:00539.16Cassyni SeminarsGuillain-Barré syndrome (GBS) is the commonest postinfectious autoimmune peripheral neuropathy of undiscerned etiology. Campylobacter jejuni (C. jejuni) is the most widely reported antecedent infection in GBS is. In this case-control investigation, we assessed the contribution of C. jejuni in GBS and ganglioside autoantibody response in a tertiary care hospital in India. This case-control study was performed on 150 treatment-naive patients with GBS and 150 age and sex matched controls from the same community. IgM immunoreactivity for C. jejuni was detected by enzyme-linked immunosorbent assay (ELISA) in sera of patients and control subjects. Autoantibody response was evaluated for single ganglioside targets GM1, GM2, GD1a, GD1b, GT1b, GQ1b as well as all possible heterodimeric complexes in patients’ sera. The immunoreactivity against C. jejuni was compared between demyelinating and axonal subtypes of GBS. C. jejuni infection was found in 48/150 (32%) of GBS patients compared to 4/150 (2.7%) of controls. This garners evidence of significantly higher immunoreactivity against C. jejuni (p<0.001, OR=17.170 CI=6.005-49.128) in the patient group compared to controls. However, the anti-C. jejuni immunoreactivity was not found to significantly differ between demyelinating and axonal subtypes of GBS (P=0.585, OR=0.79, CI=0.342-1.832). Further, C. jejuni-preceded patients demonstrated no association with any specific single ganglioside or ganglioside complex (GSC) autoantibodies. In this large case-control study, C. jejuni was observed to be an antecedent trigger of GBS and ascertaining a significantly higher prevalence among patients than controls.https://cassyni-user-files-prod.s3.amazonaws.com/SE41ZG2q3njDLmNayDfXup https://cassyni.com/events/SX4rr5kq1EUjP2id1KjgGm/abstract https://cassyni-user-files-prod.s3.amazonaws.com/4oBpgweVvm3r25yxGQM4sp https://cassyni.com/events/J7zLqCj8jjDFFXD8TEe1WM/seminar/qa https://cassyni.com/slides/outline/J7zLqCj8jjDFFXD8TEe1WM https://cassyni.com/events/J7zLqCj8jjDFFXD8TEe1WM/abstract https://cassyni-user-files-prod.s3.amazonaws.com/DJeUh5cyUKuPpuPJvxrxLW https://cassyni.com/events/J7zLqCj8jjDFFXD8TEe1WM?videoPreview=1 A Study of the Metatheory of Assertoric Syllogisticnohttps://cassyni.com/events/J7zLqCj8jjDFFXD8TEe1WM?videoPreview=12023-10-18T14:00:00+00:004048.08Logica UniversalisWe show how a semantics based on Aristotle’s texts and ecthetic proofs can be reconstructed. All truth conditions are given by means of set inclusion. Perfect syllogisms reveal to be valid arguments that deserve a validity proof. It turns out of these proofs that transitivity of set inclusion is the necessary and sufficient condition for the validity and perfection of a syllogism. The proofs of validity for imperfect syllogisms are direct proofs without conversion in a calculus of natural deduction. Transitivity of set inclusion turns out to be a necessary condition for the validity of imperfect syllogisms. As a consequence, it can be established what the main metalogical difference between a perfect and an imperfect syllogism is. The validity of the laws of conversion is also obtained by direct proofs. Finally, it is shown that and explained why some imperfect syllogisms satisfy the definition of a perfect syllogism.https://cassyni-user-files-prod.s3.amazonaws.com/DJeUh5cyUKuPpuPJvxrxLW https://cassyni.com/slides/outline/LbEN4cxkw1yjcTggzvYeEH https://cassyni.com/events/LbEN4cxkw1yjcTggzvYeEH/abstract https://cassyni-user-files-prod.s3.amazonaws.com/EsQHEvwK5hTorBqsbBUDUz https://cassyni.com/events/LbEN4cxkw1yjcTggzvYeEH?videoPreview=1 Introducing Transformative Plant Biotechnology: Itinerant plant immune receptors for food security; one of many reasons to free up use of the GM method for crop improvementnohttps://cassyni.com/events/LbEN4cxkw1yjcTggzvYeEH?videoPreview=12023-09-21T14:00:00+00:002103.6The New Phytologist FoundationPlant immunity to disease depends on detection of pathogen-derived molecules by either cell surface or intracellular immune receptors. Plant breeders have long exploited resistance gene-encoded immune receptors but introgression from wild relatives is usually hampered by linkage to deleterious alleles. Identification of immune receptor genes and introduction via the GM method avoids linkage drag and enables construction of more durable stacks of distinct immune receptors with benefits both for resistance strength and genetic durability. Furthermore, useful immune receptor genes from sexually incompatible species can be moved into a crop. I will highlight the benefits of this approach for potato improvement, and comment on a soon-to-be published Royal Society briefing document that calls for proportionate regulation of the GM method for crop improvement.https://cassyni-user-files-prod.s3.amazonaws.com/EsQHEvwK5hTorBqsbBUDUz https://cassyni.com/slides/outline/TzxRksfdWtHa73D9xoQNeH https://cassyni.com/events/TzxRksfdWtHa73D9xoQNeH/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Pw1Bv64mg5GhKoHhYhWeEJ https://cassyni.com/events/TzxRksfdWtHa73D9xoQNeH?videoPreview=1 3D Printing Enables the Fabrication of Low-Cost Microfluidic Devicesnohttps://cassyni.com/events/TzxRksfdWtHa73D9xoQNeH?videoPreview=12021-07-29T12:00:00+00:003608.68Discover Applied SciencesAssoc. Prof. José Alberto Fracassi da Silva discusses 3D Printing Enables the Fabrication of Low-Cost Microfluidic Devices.https://cassyni-user-files-prod.s3.amazonaws.com/Pw1Bv64mg5GhKoHhYhWeEJ https://cassyni.com/events/6m5SmUr4eCUFyHDz6FCEVT/abstract https://cassyni-user-files-prod.s3.amazonaws.com/2tmFDF3VeRpJ1MNvumMAdL https://cassyni.com/events/5mqUuNana1DUF3GLjCpLPF/abstract https://cassyni-user-files-prod.s3.amazonaws.com/V7XpVceXYipHvZJMUDQrgn https://cassyni.com/slides/outline/BhZVEKKK2n1ZRhWfbLFbuF https://cassyni.com/events/BhZVEKKK2n1ZRhWfbLFbuF/abstract https://cassyni-user-files-prod.s3.amazonaws.com/JstajNCHUThDAEKjfGnmQ2 https://cassyni.com/events/BhZVEKKK2n1ZRhWfbLFbuF?videoPreview=1 Instabilities and transition to turbulence in stratified-rotating flowsnohttps://cassyni.com/events/BhZVEKKK2n1ZRhWfbLFbuF?videoPreview=12020-10-29T15:00:00+00:003894.84Leeds Institute for Fluid DynamicsNo abstracthttps://cassyni-user-files-prod.s3.amazonaws.com/JstajNCHUThDAEKjfGnmQ2 https://cassyni.com/slides/outline/Q3oDW31KQan9TrSsrFkmg1 https://cassyni.com/events/Q3oDW31KQan9TrSsrFkmg1/abstract https://cassyni-user-files-prod.s3.amazonaws.com/TaFWxdhdF2BcGi6MAZLyCi https://cassyni.com/events/Q3oDW31KQan9TrSsrFkmg1?videoPreview=1 Onset of convection in rotating spherical shells : Variations with radius rationohttps://cassyni.com/events/Q3oDW31KQan9TrSsrFkmg1?videoPreview=12022-10-27T12:00:00+00:001544.24Leeds Institute for Fluid DynamicsConvection in rotating spherical layers of fluid is ubiquitous in spherical astrophysical objects like planets and stars. A complete understanding of the magnetohydrodynamics requires understanding of the linear problem—when convection onsets in these systems. This is a fluid dynamics problem that has been studied since the early 1900s. Theoretical scaling laws exist for the variation of critical quantities—the Rayleigh number Rac, the azimuthal wavenumber mc, and the angular drift frequency ωc—with respect to the Ekman number E. However, their variation with the radius ratio χ of the spherical shell is still poorly studied. To address this, we use an open source eigenvalue code Kore to compute these critical quantities over an extensive range of parameters spanning four decades in Ekman number and a dense grid of radius ratio from very thick to very thin shells, focusing on no-slip and fixed temperature boundary conditions. We find that these variations are explained well by the theoretical scaling laws, especially at low E, but variations in radius ratio also exist. We obtain scaling laws of boundary layer thicknesses and spatial extent of onset modes with respect to the Ekman number which differ only slightly from theoretical scalings. We show that our data set can be used to obtain good estimates of critical quantities in the moderate E range, where the vast majority of current geophysical and astrophysical fluid dynamics simulations are performed, yet where asymptotic theory is only moderately accurate. We further verify asymptotic predictions and determine best-fit asymptotic model coefficients.https://cassyni-user-files-prod.s3.amazonaws.com/TaFWxdhdF2BcGi6MAZLyCi https://cassyni.com/slides/outline/7kQGyUezvUW8nWkPUnbzvy https://cassyni.com/events/7kQGyUezvUW8nWkPUnbzvy/abstract https://cassyni-user-files-prod.s3.amazonaws.com/3nMP3bTKBwz9iGDN1rd9t2 https://cassyni.com/events/7kQGyUezvUW8nWkPUnbzvy?videoPreview=1 The Future of Peer Review and Reproducible Sciencenohttps://cassyni.com/events/7kQGyUezvUW8nWkPUnbzvy?videoPreview=12024-01-10T16:00:00+00:004421.8DeSci FoundationThe ability of peer review to improve manuscripts, e.g., conduct, reporting, and validity of study findings, as well as deter publication of “bad” studies is increasingly being questioned. 1 In the past I have made a call to showcase changes that occurred to each study due to peer review. 2 In this talk I will reflect on the findings of the living review of changes that occur to manuscripts (or preprints) due to peer review, as well as on the implementation of structured peer review. I will additionally share considerations on future of peer review, use of LLMs and other models in peer review, and how journals and institutions could guarantee the (computational) reproducibility of research.https://cassyni-user-files-prod.s3.amazonaws.com/3nMP3bTKBwz9iGDN1rd9t2 https://cassyni.com/slides/outline/EfUjd3iM4tFvHKjxrEAw5f https://cassyni.com/events/EfUjd3iM4tFvHKjxrEAw5f/abstract https://cassyni-user-files-prod.s3.amazonaws.com/H7Qn3Eiw7raTnLVTuLbApv https://cassyni.com/events/EfUjd3iM4tFvHKjxrEAw5f?videoPreview=1 Formation of singularities of two-dimensional soliton equations represented by L,A,B-triplesnohttps://cassyni.com/events/EfUjd3iM4tFvHKjxrEAw5f?videoPreview=12023-05-18T15:00:00+00:003792.48Journal of Mathematical SciencesWe present a geometrical mechanism of the formation of singularities of modified Novikov-Veselov and Davey-Stewartson II equations. The singular solutions are constructed by means of surface theory. These systems are represented by 𝐿, 𝐴, 𝐵-triples and we discuss the relation of such a mechanism to the degeneration of the zero level discrete spectra of the corresponding 𝐿-operators.https://cassyni-user-files-prod.s3.amazonaws.com/H7Qn3Eiw7raTnLVTuLbApv https://cassyni.com/slides/outline/9izhADF6gJittE2cqkTwMX https://cassyni.com/events/9izhADF6gJittE2cqkTwMX/abstract https://cassyni-user-files-prod.s3.amazonaws.com/b63Y62EqaYzJUdhApMsq8 https://cassyni.com/events/9izhADF6gJittE2cqkTwMX?videoPreview=1 An integrated isothermal nucleic acid amplification test to detect HPV16 and HPV18 DNA in resource-limited settingsnohttps://cassyni.com/events/9izhADF6gJittE2cqkTwMX?videoPreview=12024-11-21T19:00:00+00:002884.84Center for Cancer TrainingGlobally, there is an urgent need for low-cost and accessible cervical cancer screening tests. The most sensitive method of cervical cancer screening is testing for high-risk human papillomavirus (HPV) DNA, but current HPV DNA tests are not widely available in resource-limited settings, where the burden of cervical cancer is highest. This talk will outline the recent development of a prototype test that detects two types of HPV DNA – HPV16 and HPV18 – to help meet the need for low-cost cervical cancer screening. The developed test is low-cost, manufacturable, and point-of-care-friendly, enabled by two technologies, isothermal amplification and lateral flow detection, that reduce the cost and complexity of the test. Moreover, the test requires six user steps, produces a result in 45 minutes, and can be performed using small benchtop instruments. In field testing in low- and high-resource settings, the developed test yielded a clinically relevant limit of detection of 1,000 HPV16 or HPV18 DNA copies. Taken together, these results demonstrate the feasibility of an integrated point-of-care HPV DNA test. With the inclusion of additional high-risk HPV types, this test has the potential to meet the need for a point-of-care cervical cancer screening test in resource-limited settings.https://cassyni-user-files-prod.s3.amazonaws.com/b63Y62EqaYzJUdhApMsq8 https://cassyni.com/slides/outline/QYUSfMAjFQFyHKSPeMsjrD https://cassyni.com/events/QYUSfMAjFQFyHKSPeMsjrD/abstract https://cassyni-user-files-prod.s3.amazonaws.com/MrPHVgn7egofmxvYCqWTBC https://cassyni.com/events/QYUSfMAjFQFyHKSPeMsjrD?videoPreview=1 Aryne Chemistry in Synthesisnohttps://cassyni.com/events/QYUSfMAjFQFyHKSPeMsjrD?videoPreview=12022-11-16T16:00:00+00:008641.84Thieme GroupThe current research applications of aryne chemistry in synthesis.https://cassyni-user-files-prod.s3.amazonaws.com/MrPHVgn7egofmxvYCqWTBC https://cassyni.com/events/H8kNy6TrfXxTXHFV6CG7Q9/seminar/qa https://cassyni.com/slides/outline/H8kNy6TrfXxTXHFV6CG7Q9 https://cassyni.com/events/H8kNy6TrfXxTXHFV6CG7Q9/abstract https://cassyni-user-files-prod.s3.amazonaws.com/XRjnUuew7DLdyvfYjebqYz https://cassyni.com/events/H8kNy6TrfXxTXHFV6CG7Q9?videoPreview=1 Classification of doubly 𝒰-commuting row isometriesnohttps://cassyni.com/events/H8kNy6TrfXxTXHFV6CG7Q9?videoPreview=12024-05-03T14:00:00+00:003282.04Banach Journal of Mathematical AnalysisWe present the structure of the k-tuples of doubly $\cal U$-commuting row isometries and the $C^*$-algebras they generate, where $\cal U$ is a set of commuting unitary operators on a Hilbert space. We obtain Wold decompositions and use them to classify the $k$-tuples of doubly $\cal U$-commuting row isometries up to a unitary equivalence. This study leads to the development of a dilation theory on the regular $\cal U$-twisted polyball ${\bf B}_{\cal U}(\cal H)$, which is the set of all $k$-tuples $T:=(T_1,\ldots, T_k)$ of row contractions $T_i:=[T_{i,1}\cdots T_{i,n_i}]$ on a Hilbert space $\cal H$ satisfying certain positivity condition on the defect operator $\Delta_T(I)$ and $\cal U$-commutation relations. It is shown that many of the classical results concerning the dilation theory of contractions on Hilbert spaces have analogues for $\cal U$-twisted polyballs. This includes: Sz.-Nagy dilation theorem, von Neumann inequality, Ito and Brehmer dilations for commuting isometries and contractions, respectively, and Beurling characterization of the invariant subspaces for the unilateral shift on the Hardy space $H^2$.https://cassyni-user-files-prod.s3.amazonaws.com/XRjnUuew7DLdyvfYjebqYz https://cassyni.com/events/T1iTtmQMSh2nNoFWbm2UY5/seminar/qa https://cassyni.com/slides/outline/T1iTtmQMSh2nNoFWbm2UY5 https://cassyni.com/events/T1iTtmQMSh2nNoFWbm2UY5/abstract https://cassyni-user-files-prod.s3.amazonaws.com/3WaFX6buCFWNRNEbdaw6XY https://cassyni.com/events/T1iTtmQMSh2nNoFWbm2UY5?videoPreview=1 Multiscale Modeling of Heart Disease and Musculoskeletal Performancenohttps://cassyni.com/events/T1iTtmQMSh2nNoFWbm2UY5?videoPreview=12024-03-12T03:00:00+00:004405.72The Auckland Bioengineering InstituteComputational modeling in physiology can be integrative in several different ways. In this seminar I will use examples from our research at UC San Diego on heart disease and musculoskeletal performance to illustrate these approaches and how they can be used together. Biophysically based multiscale models integrate structurally across scales of biological organization from molecular to organism. I will show how we have combined atomistic molecular modeling, subcellular scale Markov state models, whole cell systems models with organ and system scale continuum and lumped parameter models to predict therapeutic mechanisms of 2-deoxyATP as a myosin activator in heart failure. Systems modeling of biological networks integrate the functions of biochemical modules into the emergent properties of signaling pathways that regulate genome-scale transcription. I will show how we have applied this approach to elucidate the signaling interactions that control mechanoregulated gene expression in cardiac myocytes. And statistical models and machine learning enabling the development of clinical data integration tools for better diagnosis and management of congenital heart disease and arrhythmias. While our research on the heart has focused on disease mechanisms and pathogenesis, studying trained athletes is giving us new insights into the biological principles underlying elite human performance especially in the musculoskeletal system. I will end with an overview of how we are now applying the modeling and experimental strategies we have used for studying heart disease to understand the effects of exercise training especially on skeletal muscle biology and human movement competency.https://cassyni-user-files-prod.s3.amazonaws.com/3WaFX6buCFWNRNEbdaw6XY https://cassyni.com/slides/outline/2KJFab47VoLqDLxn5YSNrR https://cassyni.com/events/2KJFab47VoLqDLxn5YSNrR/abstract https://cassyni-user-files-prod.s3.amazonaws.com/AM6DY3fngrGi67VrDaYVqg https://cassyni.com/events/2KJFab47VoLqDLxn5YSNrR?videoPreview=1 Frailty Assessment and Management in Chronic Kidney Diseasenohttps://cassyni.com/events/2KJFab47VoLqDLxn5YSNrR?videoPreview=12024-02-14T15:00:00+00:003381.08Imperial College Renal and Transplant CentreNo abstracthttps://cassyni-user-files-prod.s3.amazonaws.com/AM6DY3fngrGi67VrDaYVqg https://cassyni.com/slides/outline/DBZYbdHf9sXJjcnoh5g4oF https://cassyni.com/events/DBZYbdHf9sXJjcnoh5g4oF/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Xe3QBr1r9RA36UN5tyKqmx https://cassyni.com/events/DBZYbdHf9sXJjcnoh5g4oF?videoPreview=1 Differentiable Physics Simulations for Deep Learningnohttps://cassyni.com/events/DBZYbdHf9sXJjcnoh5g4oF?videoPreview=12022-07-06T15:00:00+00:003286.48Data-Centric Engineering JournalThis talk focuses on the possibilities that arise from recent advances in the area of deep learning for physical simulations. In particular, it will focus on differentiable physics solvers from the larger field of differentiable programming. These solvers provide crucial information for deep learning tasks in the form of gradients, which are especially important for time-dependent processes. Also, existing numerical methods for efficient solvers can be leveraged within learning tasks. This paves the way for hybrid solvers in which traditional methods work alongside pre-trained neural network components. The resulting improvements will be illustrated with examples such as wake flows and turbulence mixing layer cases. From a machine learning perspective, regression problems with physics solvers are a highly interesting class of problems. I will conclude the talk by outlining avenues for custom learning algorithms that leverage the information from the solvers at training time.https://cassyni-user-files-prod.s3.amazonaws.com/Xe3QBr1r9RA36UN5tyKqmx https://cassyni.com/events/4nYGp1Hjh67KaHSLdEM1aM/seminar/qa https://cassyni.com/slides/outline/4nYGp1Hjh67KaHSLdEM1aM https://cassyni.com/events/4nYGp1Hjh67KaHSLdEM1aM/abstract https://cassyni-user-files-prod.s3.amazonaws.com/PBeBjP5Meqti1TH8pRwvvS https://cassyni.com/events/4nYGp1Hjh67KaHSLdEM1aM?videoPreview=1 Stoic Sign-Inference and Their Lore of Fatenohttps://cassyni.com/events/4nYGp1Hjh67KaHSLdEM1aM?videoPreview=12024-03-13T15:00:00+00:005419.04Logica UniversalisThe Stoics are traditionally regarded as the founders of propositional logic. However, this is not entirely correct. They developed a theory of inference from signs (omens). And their theory became a continuation of the logical technique of Babylonian divination (in particular, of Babylonian medical forecasting). The Stoic theory was not so much propositional logic as it was a technique of propositional logic for databases consisting of IF-THEN expert rules. In the Babylonian divination, each event has a positive or negative value and all events are connected to each other. The Stoics also developed this idea and proposed a special modal logic in which logical determinism is considered an axiom. The paper reconstructs the sign-inference of the Stoics, as well as their modal logic. In particular, two Stoic squares of oppositions are proposed (for signs and for modal operators), which differ markedly from Aristotle's square.https://cassyni-user-files-prod.s3.amazonaws.com/PBeBjP5Meqti1TH8pRwvvS https://cassyni.com/slides/outline/CCGLWFzcGxRA4rxob7CjzM https://cassyni.com/events/CCGLWFzcGxRA4rxob7CjzM/abstract https://cassyni-user-files-prod.s3.amazonaws.com/LjEeXqxPWgYc5XcHKSq3j4 https://cassyni.com/events/CCGLWFzcGxRA4rxob7CjzM?videoPreview=1 Modelling the Form and Function of the Paediatric Musculoskeletal Systemnohttps://cassyni.com/events/CCGLWFzcGxRA4rxob7CjzM?videoPreview=12024-04-09T04:00:00+00:002869.52The Auckland Bioengineering InstituteMusculoskeletal development in a paediatric population is an important but poorly understood domain. Understanding how bone geometry changes with growth, allows development of more accurate models in a paediatric population. Which can be used for applications such as musculoskeletal and finite element modelling, to help understand information about movement including joint contact and muscle forces. Utilising a dataset of 333 CT scans of children aged 4 – 18 years old, this thesis explores changes in musculoskeletal geometry with growth. This thesis evaluates clinical bone measurement changes with growth. Three-dimensional angular and linear measurements from the pelvis, femur, and tibia/fibula were extracted. Notably, femoral and tibial torsion remained consistent between sexes, while sex-related differences in linear measurements emerged in children aged 13 and older. Females consistently displayed smaller linear measurements compared to males of the same age/height, possibly contributing to increased injury risks during adolescence. Accurate estimation of the hip joint centre is vital for assessing hip joint motion and related parameters. In this thesis, three different hip joint centre determination methods were evaluated in a paediatric population—regression equations, linear scaling, and shape model prediction. Our novel shape model prediction exhibited superior accuracy compared to alternative methods. Addressing the challenge of rapidly generating musculoskeletal geometry in a paediatric population, this thesis presents population-based shape models for lower limb bones. These models utilised principal component analysis on segmented pelvis, femur, and tibia/fibula data, to accurately predict bone geometry from demographic and linear bone measurements. Subsequent articulation of the shape model allowed for both shape and pose prediction of lower limb bones from bone surface landmarks. The generated shape models outperformed traditional linear scaling methods, offering a more accurate and accessible solution for paediatric musculoskeletal geometry prediction. Overall, this thesis underscores the importance of understanding changes in musculoskeletal geometry with growth and provides valuable tools and methods which capture these changes. This thesis not only illustrates sex-related skeletal differences but has also pioneered the use of statistical shape models in a paediatric population to predict lower limb musculoskeletal geometry. These findings hold significant implications for clinical and research applications, advancing our understanding of paediatric musculoskeletal geometry.https://cassyni-user-files-prod.s3.amazonaws.com/LjEeXqxPWgYc5XcHKSq3j4 https://cassyni.com/events/NaMcRKLhLhnw5BWvW2VpBF/seminar/qa https://cassyni.com/slides/outline/NaMcRKLhLhnw5BWvW2VpBF https://cassyni.com/events/NaMcRKLhLhnw5BWvW2VpBF/abstract https://cassyni-user-files-prod.s3.amazonaws.com/NNrt7m2CFUE42crSb9L9EN https://cassyni.com/events/NaMcRKLhLhnw5BWvW2VpBF?videoPreview=1 Supersensitive wireless sensing - how cracks can help composites get smarter?nohttps://cassyni.com/events/NaMcRKLhLhnw5BWvW2VpBF?videoPreview=12024-06-05T14:00:00+00:003852.04Department of AeronauticsNon-intrusive embedded sensors are a deeply needed technology for monitoring of large scale composite structures. Composite structures such as pipelines, tanks, aircraft, ships, and ground vehicles confront some challenges with embedding strain sensing systems incorporating strain gauges or optical fibers that can introduce delamination, cracking and structural failure of the host in addition to the need for dedicated and expensive equipment. We present the evolution of the research in our lab, that led to our latest RF sensing technology with high sensing sensitivity. This work started with the quest for supersensitive piezoresistive sensors, in which the unique response of cracked structures is leveraged. We illustrate, in the field of stretchable electronics, how the sensors properties can be controlled by tailoring the crack networks. While interesting, super piezoresistive sensors are however not practical, as difficult to integrate in wireless systems, and with poor reproducibility. However, this initial work paved the way for a new generation of sensors based on piezo capacitance. These leverage the unique properties of capacitive sensors with superpiezoresistive electrodes. We develop a flexible and thin sensor based on LC circuit where the capacitance is considered a sensing unit. We introduce a controlled network of cracks in the parallel electrodes and benefit from the way these cracks modify the electromagnetic wave penetration inside the parallel plate capacitor. The tailored network of cracks creates a piezoresistive effect that leads to a transmission line behavior of the capacitance resulting in a tremendous increase in sensitivity. This unconventional change in capacitance of the LC oscillator allows a large shifting in resonance frequency of the flexible circuit, producing a sensitive wireless strain sensor with a Gauge factor of 50 for less than 1% strain. Eliminating wires, power source, and electronic chip from the sensor body allow the sensor to be integrated easily inside the composites materials while maintaining the materials' mechanical performance. The experimental results show the ability of our cracked wireless strain sensor to detect small strain signals through the composites structure with high accuracy. The developed sensor is intended to be a part of a wireless sensor network (WSN ) for monitoring large composites structures. https://cassyni-user-files-prod.s3.amazonaws.com/NNrt7m2CFUE42crSb9L9EN https://cassyni.com/slides/outline/P51DTzzDnALz4x3p6TncSZ https://cassyni.com/events/P51DTzzDnALz4x3p6TncSZ/abstract https://cassyni-user-files-prod.s3.amazonaws.com/72vAkpvugzrduXBhRP1EBg https://cassyni.com/events/P51DTzzDnALz4x3p6TncSZ?videoPreview=1 Everything You Always Wanted to Know About Icebergs Melting* (*But were afraid to ask)nohttps://cassyni.com/events/P51DTzzDnALz4x3p6TncSZ?videoPreview=12024-02-15T15:00:00+00:003952.64The Edinburgh Fluid Dynamics Group (EFDG)Iceberg calving accounts for half of the mass discharge from the Greenland and Antarctic ice sheets. Through their displacement and progressive melt, icebergs can impact both the regional and large-scale ocean circulation and marine ecosystems. Notwithstanding their importance, our understanding of where and how icebergs melt is limited and their representation in ocean and climate models is oversimplistic. As a result, model-based predictions of iceberg melt rates, of the fate of the meltwater, and of its impact on the ocean are highly uncertain. The focus of this lecture will be on laboratory experiments investigating the influence of the ambient flow, the icebergs’ aspect ratio and the Earth rotation on iceberg melting. https://cassyni-user-files-prod.s3.amazonaws.com/72vAkpvugzrduXBhRP1EBg https://cassyni.com/events/Vz5g7a3Zva6mZm3PTuMYbF/abstract https://cassyni-user-files-prod.s3.amazonaws.com/GtzFFA1bBSqW62jqNr62C6 https://cassyni.com/events/YTKhLzHC7rsFvhWx1bGBKB/seminar/qa https://cassyni.com/slides/outline/YTKhLzHC7rsFvhWx1bGBKB https://cassyni.com/events/YTKhLzHC7rsFvhWx1bGBKB/abstract https://cassyni-user-files-prod.s3.amazonaws.com/A98kuXLNGB7ofvbwGBYWUN https://cassyni.com/events/YTKhLzHC7rsFvhWx1bGBKB?videoPreview=1 Nonlinear acoustics of an aperture under grazing flownohttps://cassyni.com/events/YTKhLzHC7rsFvhWx1bGBKB?videoPreview=12024-07-02T09:00:00+00:003665.84Royal Society PublishingThis work presents a mathematical model of a dynamically forced, acoustically compact aperture subject to one-sided mean grazing flow in two or three dimensions. By contrast to other simplified theoretical representations of a grazed aperture, the one proposed in this contribution considers some of the nonlinear effects a reduced order model should naturally inherit from the conservation equations governing the primary system’s dynamics. Furthermore, unlike other nonlinear developments, this one is able to reproduce the acoustic forcing amplitude dependence of the fundamental-frequency-based impedance, measured in recent experiments, without relying on empirical parameters. This nonlinear model offers further insight into the dominant physical mechanisms determining the aforementioned behaviour and allows reasonable a priori estimates of the aeroacoustic dynamics of the aperture. This could be used as a building block of more sophisticated systems or for the derivation of even simpler representations suitable for acoustic network modelling.https://cassyni-user-files-prod.s3.amazonaws.com/A98kuXLNGB7ofvbwGBYWUN https://cassyni.com/slides/outline/R3bdejaKXzZkAfL3TReYs7 https://cassyni.com/events/R3bdejaKXzZkAfL3TReYs7/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Y9AHAR72mnAQZdVpyhHnj8 https://cassyni.com/events/R3bdejaKXzZkAfL3TReYs7?videoPreview=1 Incorporating Symmetry for Learning Spatiotemporal Dynamicsnohttps://cassyni.com/events/R3bdejaKXzZkAfL3TReYs7?videoPreview=12021-11-05T14:00:00+00:003665.0AI Institute in Dynamic SystemsWhile deep learning has shown tremendous success in many scientific domains, it remains a grand challenge to incorporate physical principles into such models. In this talk, I will demonstrate how to incorporate symmetries into deep neural networks and significantly improve physical consistency, sample efficiency, and generalization in learning spatiotemporal dynamics. I will showcase the applications of these models to challenging problems such as turbulence forecasting and trajectory prediction for autonomous vehicles.https://cassyni-user-files-prod.s3.amazonaws.com/Y9AHAR72mnAQZdVpyhHnj8 https://cassyni.com/slides/outline/TWqet9owjHLEXboc17ZBb3 https://cassyni.com/events/TWqet9owjHLEXboc17ZBb3/abstract https://cassyni-user-files-prod.s3.amazonaws.com/VJuZgKFBLqn55rndwj4nc6 https://cassyni.com/events/TWqet9owjHLEXboc17ZBb3?videoPreview=1 Automated Tour Design in the Saturnian System, Assessment of dynamical models for transitioning from the Circular Restricted Three-Body Problem to an ephemeris model with applicationsnohttps://cassyni.com/events/TWqet9owjHLEXboc17ZBb3?videoPreview=12024-05-31T13:00:00+00:003556.04Celestial Mechanics and Dynamical AstronomyFuture missions to Enceladus would benefit from multi-moon tours that leverage $V_\infty$ on resonant orbits to progressively transfer between moons. Such resonance hopping trajectories present a vast search space for global optimization due to the different combinations of available resonances and flyby velocities. The proposed multi-objective tour design algorithm optimizes entire moon tours from Titan to Enceladus via grid-based dynamic programming, in which the computation time is significantly reduced by discretization of the design variables and pre-computation of a database of $V_\infty$-leveraging transfers. The result unveils a complete trade space of the moon tour design to Enceladus, and the obtained solution is validated in a full-ephemeris model. While the Circular Restricted Three-Body Problem (CR3BP) provides useful structures for various applications, transitioning the solutions from the CR3BP to a higher-fidelity ephemeris model while maintaining specific characteristics remains non-trivial. An analytical approach is leveraged to provide additional insight on the perturbations that are present in an ephemeris model. For the Earth–Moon CR3BP, pulsation of the Earth–Moon distance and solar gravity are identified as key components contributing to the additional accelerations, where patterns are illustrated through simplified mathematical relationships and graphics. Utilizing these findings, capabilities and limitations of two intermediate models, the Elliptic Restricted Three-Body Problem and the Bi-Circular Restricted Four-Body Problem, are assessed within the context of transitioning from the CR3BP to a realistic ephemeris model. A sample transition process for Earth–Moon L$_2$ halo orbits is provided, leveraging the insight from the proposed analytical approach.https://cassyni-user-files-prod.s3.amazonaws.com/VJuZgKFBLqn55rndwj4nc6 https://cassyni.com/events/8FZ65VaUcRjMm1m75oxstq/seminar/qa https://cassyni.com/slides/outline/8FZ65VaUcRjMm1m75oxstq https://cassyni.com/events/8FZ65VaUcRjMm1m75oxstq/abstract https://cassyni-user-files-prod.s3.amazonaws.com/KXX1ttCfgR8GWkVZkNHSVL https://cassyni.com/events/8FZ65VaUcRjMm1m75oxstq?videoPreview=1 Time-varying metamaterials for lightnohttps://cassyni.com/events/8FZ65VaUcRjMm1m75oxstq?videoPreview=12024-06-25T13:00:00+00:002783.04MetaMATMetamaterials have revolutionised the way we control light transport and generation. Yet, to date, they rely on static and passive architectures, only redistributing incident wave energy - for example in a metalens, or a cloak - with no power to locally absorb or produce it to enhance responses. Here I will discuss our first steps towards driven photonic systems, able to convert energy to function and perform actions. I will report on double-slit time diffraction at optical frequencies in time-varying metamaterials [1] and how we can extend the modulation of the linear refractive index to the modulation of the nonlinear response [2]. Moreover, I will discuss how time-modulation can lead to new optical phenomena. References [1] Romain Tirole, Stefano Vezzoli, Emanuele Galiffi, Iain Robertson, Dries Maurice, Benjamin Tilmann, Stefan A Maier, John B Pendry, Riccardo Sapienza, Double-slit time diffraction at optical frequencies, Nature Physics 19, 999 (2023). [2] Romain Tirole, Stefano Vezzoli, Dhruv Saxena, Shu Yang, TV Raziman, Emanuele Galiffi, Stefan A Maier, John B Pendry, Riccardo Sapienza, Second harmonic generation at a time-varying interface, arXiv:2401.05536 (2024). https://cassyni-user-files-prod.s3.amazonaws.com/KXX1ttCfgR8GWkVZkNHSVL https://cassyni.com/slides/outline/3K53cf7EDrCLMv3m5LFtAh https://cassyni.com/events/3K53cf7EDrCLMv3m5LFtAh/abstract https://cassyni-user-files-prod.s3.amazonaws.com/49s8AYLPXEtACpDxxPej7L https://cassyni.com/events/3K53cf7EDrCLMv3m5LFtAh?videoPreview=1 Identifying Dominant Balance Physics from Datanohttps://cassyni.com/events/3K53cf7EDrCLMv3m5LFtAh?videoPreview=12020-02-24T14:00:00+00:00740.36Brunton LabThroughout the history of science, physics-based modeling has relied on judiciously approximating observed dynamics as a balance between a few dominant processes. However, this traditional approach is mathematically cumbersome and only applies in asymptotic regimes where there is a strict separation of scales in the physics. Here, we automate and generalize this approach to non-asymptotic regimes by introducing the idea of an equation space, in which different local balances appear as distinct subspace clusters. Unsupervised learning can then automatically identify regions where groups of terms may be neglected. We show that our data-driven balance models successfully delineate dominant balance physics in a much richer class of systems. In particular, this approach uncovers key mechanistic models from the past hundred years in turbulence, nonlinear optics, geophysical fluids, and neuroscience.https://cassyni-user-files-prod.s3.amazonaws.com/49s8AYLPXEtACpDxxPej7L https://cassyni.com/slides/outline/Dggjb1hFSTpktRLu6SCmrD https://cassyni.com/events/Dggjb1hFSTpktRLu6SCmrD/abstract https://cassyni-user-files-prod.s3.amazonaws.com/8kw8SyHqS4VRyhWR3bq8ri https://cassyni.com/events/Dggjb1hFSTpktRLu6SCmrD?videoPreview=1 Optimized thread-block arrangement in a GPU implementation of a linear solver for atmospheric chemistry mechanismsnohttps://cassyni.com/events/Dggjb1hFSTpktRLu6SCmrD?videoPreview=12024-06-25T10:05:00+00:002228.68Computer Physics CommunicationsEarth system models (ESM) demand significant hardware resources and energy consumption to solve atmospheric chemistry processes. Recent studies have shown improved performance from running these models on GPU accelerators. Nonetheless, there is room for improvement in exploiting even more GPU resources. This study proposes an optimized distribution of the chemical solver's computational load on the GPU, named Block-cells. Additionally, we evaluate different configurations for distributing the computational load in an NVIDIA GPU. We use the linear solver from the Chemistry Across Multiple Phases (CAMP) framework as our test bed. An intermediate-complexity chemical mechanism under typical atmospheric conditions is used. Results demonstrate a 35× speedup compared to the single-CPU thread reference case. Even using the full resources of the node (40 physical cores) on the reference case, the Block-cells version outperforms them by 50%. The Block-cells approach shows promise in alleviating the computational burden of chemical solvers on GPU architectures.https://cassyni-user-files-prod.s3.amazonaws.com/8kw8SyHqS4VRyhWR3bq8ri https://cassyni.com/slides/outline/AE9WGEAaNFx7rj3LSmppKP https://cassyni.com/events/AE9WGEAaNFx7rj3LSmppKP/abstract https://cassyni-user-files-prod.s3.amazonaws.com/SLYRsPFccefFv2HFzdQbpz https://cassyni.com/events/AE9WGEAaNFx7rj3LSmppKP?videoPreview=1 Wall-models of turbulent flows via scientific multi-agent reinforcement learningnohttps://cassyni.com/events/AE9WGEAaNFx7rj3LSmppKP?videoPreview=12021-11-12T14:00:00+00:003364.52AI Institute in Dynamic SystemsThe predictive capabilities of turbulent flow simulations, critical for aerodynamic design and weather prediction, hinge on the choice of turbulence models. The abundance of data from experiments and simulations and the advent of machine learning have provided a boost to turbulence modeling efforts. However, simulations of turbulent flows remain hindered by the inability of heuristics and supervised learning to model the near-wall dynamics. We address this challenge by introducing scientific multi-agent reinforcement learning (SciMARL) for the discovery of wall models for large-eddy simulations (LES). In SciMARL, discretization points act also as cooperating agents that learn to supply the LES closure model. The agents self-learn using limited data and generalize to higher Reynolds numbers in reproducing key flow quantities.https://cassyni-user-files-prod.s3.amazonaws.com/SLYRsPFccefFv2HFzdQbpz https://cassyni.com/slides/outline/ChPXVeQCZYicDfWtzTjT3K https://cassyni.com/events/ChPXVeQCZYicDfWtzTjT3K/abstract https://cassyni-user-files-prod.s3.amazonaws.com/6M8ypWsQrUyNh9mNNKtcKg https://cassyni.com/events/ChPXVeQCZYicDfWtzTjT3K?videoPreview=1 Integrative plant holobiont studies for innovative and sustainable agriculturenohttps://cassyni.com/events/ChPXVeQCZYicDfWtzTjT3K?videoPreview=12024-06-06T17:40:00+00:001746.16New Phytologist Foundation Plants do not live in isolation. Instead, they are holobionts that harbor a diverse and structured microbiota. Our research on the Agave and cacti microbiome shows that microorganisms influence these CAM perennial species' fitness, productivity, and tolerance to drought. These plant-microbe interactions allow us to understand plant and microbial biology while providing creative and sustainable solutions to the varied challenges imposed by climate change.https://cassyni-user-files-prod.s3.amazonaws.com/6M8ypWsQrUyNh9mNNKtcKg https://cassyni.com/slides/outline/M6SRPtv1Rh4KXUZmLszwtq https://cassyni.com/events/M6SRPtv1Rh4KXUZmLszwtq/abstract https://cassyni-user-files-prod.s3.amazonaws.com/WRkBpqfFFYxWd4zsX6d7ci https://cassyni.com/events/M6SRPtv1Rh4KXUZmLszwtq?videoPreview=1 Mating system and environment predict the direction and extent of introgression in incipient Clarkia speciesnohttps://cassyni.com/events/M6SRPtv1Rh4KXUZmLszwtq?videoPreview=12024-06-08T14:00:00+00:00925.08New Phytologist Foundation Introgression is pervasive across the tree of life, but varies across taxa, geography, and genomic regions. However, the factors modulating this variation and how they may be affected by global change are not well-understood. Here, we used 200 genomes and a 15-year site-specific environmental dataset to investigate the effect of environmental variation and mating system divergence on the magnitude of introgression between a recently diverged outcrosser-selfer pair of annual plants in the genus Clarkia. These sister taxa diverged very recently and subsequently came into secondary sympatry where they form replicated contact zones. Consistent with observations of other outcrosser-selfer pairs, we found that introgression was asymmetric between taxa, with substantially more introgression from the selfer to the outcrosser. This asymmetry was caused by a bias in the direction of initial F1 hybrid formation and subsequent backcrossing. We also found extensive variation in the outcrosser’s admixture proportion among contact zones, which was predicted nearly entirely by interannual variance in spring precipitation. Greater fluctuations in spring precipitation resulted in higher admixture proportions, likely mediated by the effects of spring precipitation on the expression of traits that determine premating reproductive isolation. Climate-driven hybridization dynamics may be particularly affected by global change, potentially reshaping species boundaries and adaptation to novel environments.https://cassyni-user-files-prod.s3.amazonaws.com/WRkBpqfFFYxWd4zsX6d7ci https://cassyni.com/events/PZgSdK9dcypotR3KtZuacm/seminar/qa https://cassyni.com/slides/outline/PZgSdK9dcypotR3KtZuacm https://cassyni.com/events/PZgSdK9dcypotR3KtZuacm/abstract https://cassyni-user-files-prod.s3.amazonaws.com/AgRjbKHAVbgrcNYfuYaTLJ https://cassyni.com/events/PZgSdK9dcypotR3KtZuacm?videoPreview=1 Introduction to the 9th International Biometals Webinars, Clostridioides difficile activates an anticipatory iron storage strategy in response to nutritional immunity, Iron-sulfur protein biogenesis in eukaryotes: How all startsnohttps://cassyni.com/events/PZgSdK9dcypotR3KtZuacm?videoPreview=12024-11-05T14:00:00+00:004982.72BioMetalsIntroduce speakers All cells require nutrient metal to carry out essential biochemical processes. This requirement is something that the vertebrate immune system has exploited as a strategy to defend against infection by restricting microbial access to nutrient metal. This process of nutrient restriction during infection is called “nutritional immunity”. Bacterial pathogens have evolved elaborate mechanisms to circumvent nutritional immunity and acquire metal during infection. This struggle for nutrient metal impacts both microbial virulence as well as the immune response of the host, profoundly affecting the outcome of host-pathogen interactions. Nutrient metals are acquired through the diet, establishing the gastrointestinal tract as a primary battleground in the struggle for metal between microbes and the vertebrate host. Clostridioides difficile is the leading cause of hospital acquired gastrointestinal infections, and this organism must compete with both the host and other microbes to obtain the critical nutrients that it needs to colonize and cause disease. To study these interactions in more detail, we have combined microbial genetics with murine models of infection and advanced imaging modalities. We have applied this platform to the study of C. difficile infection, leading to the discovery of infection-associated alterations in the distribution and abundance of nutrients in tissue. These data have led to the discovery of C. difficile factors that are required to acquire and metabolize nutrients and have led to unexpected findings regarding how nutrient metals and antibiotic resistance intersect in this organism. Iron-sulfur (Fe-S) proteins play crucial roles in numerous important cellular processes including respiration, metabolism, genome maintenance, protein translation and antiviral response. The synthesis of Fe S clusters and their insertion into apoproteins in (non-green) eukaryotes is a multifaceted process involving over 30 proteins located in mitochondria and cytosol. The biogenesis of mitochondrial [2Fe-2S] and [4Fe-4S] proteins is orchestrated by components of the iron-sulfur cluster assembly (ISC) machinery which was inherited from bacteria during evolution (Braymer et al., 2017; Lill & Freibert, 2020; Lill, 2020). Cytosolic and nuclear Fe-S protein assembly also relies on the function of this machinery, yet additionally requires the mitochondrial ABC exporter ABCB7 and the cytosolic iron-sulfur protein assembly (CIA) machinery (Paul et al., 2015). Interestingly, mitochondrial Fe-S protein biogenesis co-evolved with the existence of the entire organelle, defining this process as both the minimal and essential function of mitochondria (Braymer et al., 2021). A combination of in vivo and in vitro studies have generated a good understanding of the general outline of the sequential steps of Fe-S protein biogenesis. Currently, the detailed molecular mechanisms underlying the individual reaction steps are investigated by using cell biological, biochemical, spectroscopic, and structural approaches. In this seminar, I will present some of our recent structural, spectroscopic, and biochemical insights into the molecular mechanisms underlying [2Fe-2S] cluster assembly in mitochondria. The mechanism may closely resemble that in the bacterial ISC system. These mechanistic insights may eventually help advancing our molecular understanding of the biochemical consequences of numerous “Fe-S diseases” linked to mutations in almost any of the ISC genes (Lill & Freibert, 2020). Specifically, our studies suggest a mechanism for frataxin function, a protein functionally impaired in Friedreich’s ataxia. https://cassyni-user-files-prod.s3.amazonaws.com/AgRjbKHAVbgrcNYfuYaTLJ https://cassyni.com/events/6GzJ1PWGFxShDYH4LEBDM7/seminar/qa https://cassyni.com/slides/outline/6GzJ1PWGFxShDYH4LEBDM7 https://cassyni.com/events/6GzJ1PWGFxShDYH4LEBDM7/abstract https://cassyni-user-files-prod.s3.amazonaws.com/EzWKf2qwkopkvuyYo78pqk https://cassyni.com/events/6GzJ1PWGFxShDYH4LEBDM7?videoPreview=1 Cluster structures on spinor helicity and momentum twistor varietiesnohttps://cassyni.com/events/6GzJ1PWGFxShDYH4LEBDM7?videoPreview=12024-08-14T15:00:00+00:003306.12The Journal of Algebraic CombinatoricsWe study cluster structures on spinor helicity and momentum twistor varieties which describe the kinematic spaces of massless scattering with and without dual conformal symmetry. Both are instances of partial flag varieties. We exhibit embeddings of the corresponding cluster algebras into cluster algebras of sufficiently large Grassmannians and show how the former is obtained by specializing and freezing certain cluster variables from the latter. This is work in progress with Jianrong Li.https://cassyni-user-files-prod.s3.amazonaws.com/EzWKf2qwkopkvuyYo78pqk https://cassyni.com/slides/outline/3okGmyGe4fgABP3GsSNrLu https://cassyni.com/events/3okGmyGe4fgABP3GsSNrLu/abstract https://cassyni-user-files-prod.s3.amazonaws.com/6SGj4PyvyExhiknp7qYj9G https://cassyni.com/events/3okGmyGe4fgABP3GsSNrLu?videoPreview=1 CNTN4 modulates neural elongation through interplay with APPnohttps://cassyni.com/events/3okGmyGe4fgABP3GsSNrLu?videoPreview=12024-08-19T13:00:00+00:002892.64Royal Society PublishingThe neuronal cell adhesion molecule contactin-4 (CNTN4) is genetically associated with autism spectrum disorder (ASD) and other psychiatric disorders. Cntn4-deficient mouse models have previously shown that CNTN4 plays important roles in axon guidance and synaptic plasticity in the hippocampus. However, the pathogenesis and functional role of CNTN4 in the cortex has not yet been investigated. Our study found a reduction in cortical thickness in the motor cortex of Cntn4 −/− mice, but cortical cell migration and differentiation were unaffected. Significant morphological changes were observed in neurons in the M1 region of the motor cortex, indicating that CNTN4 is also involved in the morphology and spine density of neurons in the motor cortex. Furthermore, mass spectrometry analysis identified an interaction partner for CNTN4, confirming an interaction between CNTN4 and amyloid-precursor protein (APP). Knockout human cells for CNTN4 and/or APP revealed a relationship between CNTN4 and APP. This study demonstrates that CNTN4 contributes to cortical development and that binding and interplay with APP controls neural elongation. This is an important finding for understanding the physiological function of APP, a key protein for Alzheimer’s disease. The binding between CNTN4 and APP, which is involved in neurodevelopment, is essential for healthy nerve outgrowth. Image credit: [ManuelSchottdorf](https://commons.wikimedia.org/wiki/File:GFP_Neurons.png)https://cassyni-user-files-prod.s3.amazonaws.com/6SGj4PyvyExhiknp7qYj9G https://cassyni.com/slides/outline/G9xNw4Sm37X254H5qnwaV3 https://cassyni.com/events/G9xNw4Sm37X254H5qnwaV3/abstract https://cassyni-user-files-prod.s3.amazonaws.com/FJrmY4hv351BAKKDgeZ1Nn https://cassyni.com/events/G9xNw4Sm37X254H5qnwaV3?videoPreview=1 Positive Desch-Schappacher perturbations of bi-continuous semigroups on AM-spacesnohttps://cassyni.com/events/G9xNw4Sm37X254H5qnwaV3?videoPreview=12021-04-29T14:00:00+00:002746.0Positivity Journal, SpringerNatureWe consider positive Desch–Schappacher perturbations of bi-continuous semigroups on AM-spaces with an additional property concerning the additional locally convex topology. As an examples, we discuss perturbations of the left-translation semigroup on the space of bounded continuous function on the real line and perturbations of the implemented semigroup on the space of bounded linear operators. Dynamical processes occurring, e.g., in population models, quantum mechanics, or the financial world, are frequently expressed by a particular class of partial differential equations, the so-called evolution equations. A general operator theoretical method for dealing with those equations is the one using abstract Cauchy problems on a Banach space. In some cases, it is possible to write a given operator (A,D(A)) as a sum of simpler operators and this is where perturbation theory enters the area of evolution equations. The general question is: given a generator (A,D(A)) and another linear operator (B,D(B)), under which conditions does the operator A+B generate a semigroup? When talking about one-parameter semigroups of linear operators on Banach spaces, mostly C0-semigroups come to mind. Nevertheless, there are operator semigroups which are not strongly continuous with respect to the norm on the Banach space but for some weaker additional locally convex topology. This is one of the reasons why people are interested in different continuity concepts of semigroups and more general solutions in order to overcome these limitations of strongly continuous semigroups. One of the auspicious approaches to this gives rise to so-called bi-continuous semigroups, which were introduced by Kühnemund.https://cassyni-user-files-prod.s3.amazonaws.com/FJrmY4hv351BAKKDgeZ1Nn https://cassyni.com/events/AipjRYKzD5RwgC2rEswnVb/abstract https://cassyni-user-files-prod.s3.amazonaws.com/5j6cYFwfKL7zGtq3tEpvMU https://cassyni.com/events/J8aRERYkCJfWKFFiVKjxYD/seminar/qa https://cassyni.com/slides/outline/J8aRERYkCJfWKFFiVKjxYD https://cassyni.com/events/J8aRERYkCJfWKFFiVKjxYD/abstract https://cassyni-user-files-prod.s3.amazonaws.com/9o8hdoVC97Cc1kL2tb4SSz https://cassyni.com/events/J8aRERYkCJfWKFFiVKjxYD?videoPreview=1 On Flow Controlnohttps://cassyni.com/events/J8aRERYkCJfWKFFiVKjxYD?videoPreview=12025-01-28T15:00:00+00:003615.56Experiments in FluidsOn Flow Control Israel Wygnanski The University of Arizona, Tucson, AZ, 85721, USA Abstract Active Flow Control (AFC) emerged from Boundary Layer Control (BLC) where the entire boundary layer concept implied that the pressure distribution over a surface is dictated by the surface’s geometry and hence the lift and the pitching moment acting on a streamlined body are determined by an inviscid flow solution. This is incorrect in the presence of a jet, a wall-jet and even more so when either the jet or the surrounding flow is three dimensional. Thus, in order that AFC to become a viable technology, some of the preconceptions associated with BLC must be discarded. In particular, the momentum coefficient used to characterize the effectiveness of AFC should be replaced by another variable that represents a conserved quantity that is independent of specific installations. Injected momentum is a vector quantity whose effect on a surface like a wing depends on its specific design, location, and orientation. This simple fact was rarely considered by companies and researchers attempting to use AFC for improving wing performance or replacing traditional control surfaces on an airplane. A successful flow control device should be small and use little energy to create a large, desirable change in the flow. It often exploits local instabilities and interacts with large vortices to achieve the desired effect, and the present seminar will provide some examples of this approach. https://cassyni-user-files-prod.s3.amazonaws.com/9o8hdoVC97Cc1kL2tb4SSz https://cassyni.com/events/LbpSTqnNPbRzgBjH31ebG9/seminar/qa https://cassyni.com/slides/outline/LbpSTqnNPbRzgBjH31ebG9 https://cassyni.com/events/LbpSTqnNPbRzgBjH31ebG9/abstract https://cassyni-user-files-prod.s3.amazonaws.com/CWpg5eZmMsWoAKPJ1o2WZ4 https://cassyni.com/events/LbpSTqnNPbRzgBjH31ebG9?videoPreview=1 Exploring nanoscale systems using theory and molecular dynamics simulationnohttps://cassyni.com/events/LbpSTqnNPbRzgBjH31ebG9?videoPreview=12024-10-30T23:15:00+00:003247.04The MacDiarmid Institute for Advanced Materials and NanotechnologyMany theoretical and computational avenues can be used in the study of materials. Density functional theory (DFT) is a popular method for describing and predicting material structures or behaviours based on their electronic properties. However, DFT can be computationally expensive, so length and timescales are a limiting factor. Molecular dynamics (MD) is another computational method that models atoms classically using force fields. These force fields approximate how different atomic constituents should interact together. This method can approach much larger length and timescales at the cost of the accuracy enjoyed by DFT. In this talk, I discuss different applications of MD in the study of materials, from the growth of nanofilaments to model resistive switching, the stability of metal nanowires and their melting mechanisms during the solid-liquid phase transition, to the self-assembly of Janus particles suspended in a fluid. While much of this work is in progress, the wide-ranging applicability of MD to model different physical systems is apparent. https://cassyni-user-files-prod.s3.amazonaws.com/CWpg5eZmMsWoAKPJ1o2WZ4 https://cassyni.com/events/UzqiFTnHrNqyqX5k6ryeV3/seminar/qa https://cassyni.com/slides/outline/UzqiFTnHrNqyqX5k6ryeV3 https://cassyni.com/events/UzqiFTnHrNqyqX5k6ryeV3/abstract https://cassyni-user-files-prod.s3.amazonaws.com/WJCmmgYEDktK7495suKZyY https://cassyni.com/events/UzqiFTnHrNqyqX5k6ryeV3?videoPreview=1 Orbital dynamics of smart dust with Poynting-Robertson and solar wind drag, Circular restricted full three-body problem with rigid-body spacecraft dynamics in binary asteroid systemsnohttps://cassyni.com/events/UzqiFTnHrNqyqX5k6ryeV3?videoPreview=12024-09-27T13:00:00+00:004043.56Celestial Mechanics and Dynamical AstronomySmart dust devices are tiny systems-on-a-chip platforms capable of sensing, storing and transmitting data wirelessly as part of a large network with distributed capabilities. Previous works investigated the long-term orbital evolution of smart dust in space by studying the combined effect of gravitational perturbations, solar radiation pressure (SRP), and atmospheric drag. In the current work, the problem of finding long-term orbital equilibria conditions for smart dust is recast and extended to include Poynting-Robertson and Solar Wind (PRSW) drag. By including the PRSW effects and defining new equilibrium conditions on the orbital orientation, some additional partial equilibrium solutions are found. Moreover, it is shown that even though PRSW is not dominant compared to SRP or J2, it still influences the evolution of the relative Sun-orbit orientation. For orbits with higher initial perigee altitudes, where drag and J2 effects subside, it is shown that PRSW influences long-term orbital behaviour, and should be considered in the orbit design scheme of smart dust devices. Coupling between the rotational and translational motion of a rigid body can have a profound effect on spacecraft motion in complex dynamical environments. While there is a substantial amount of study of rigid-body coupling in a non-uniform gravitational field, the spacecraft is often considered as a point-mass vehicle. By contrast, the full-N body problem (FNBP) evaluates the mutual gravitational potential of the rigid-body celestial objects and any other body, such as a spacecraft, under their influence and treats all bodies, including the spacecraft, as a rigid body. Furthermore, the perturbing effects of the FNBP become more pronounced as the celestial bodies become smaller and/or more significantly aspherical. Utilizing the comprehensive framework of dynamics and gravitational influences within the FNBP, this research investigates the dynamics of spacecraft modeled as rigid bodies in binary systems characterized by nearly circular mutual orbits. The paper presents an examination of the perturbation effects that arise in this circular restricted full three-body problem (CRF3BP), aiming to assess and validate the extent of these effects on the spacecraft’s overall motion. Numerical results provided for spacecraft motion in the CRF3BP in a binary asteroid system demonstrate non-negligible trajectory divergence when utilizing rigid-body versus point mass spacecraft models. These results also investigate the effects of shape and inertia tensors of the bodies and solar radiation pressure in those models.https://cassyni-user-files-prod.s3.amazonaws.com/WJCmmgYEDktK7495suKZyY https://cassyni.com/slides/outline/6mfXAhfg6mvX31Ga8LJBXK https://cassyni.com/events/6mfXAhfg6mvX31Ga8LJBXK/abstract https://cassyni-user-files-prod.s3.amazonaws.com/HWJ1HjyDbvt1BAm4Js4gEz https://cassyni.com/events/6mfXAhfg6mvX31Ga8LJBXK?videoPreview=1 Integrating taxonomic, functional, and strain-level profiling of diverse microbial communities with bioBakery 3nohttps://cassyni.com/events/6mfXAhfg6mvX31Ga8LJBXK?videoPreview=12021-11-09T11:00:00+00:0062.6Microbiome Virtual International Forum Culture-independent analyses of microbial communities dramatically improved in the last decade, thanks to advances in methods for biological profiling via shotgun metagenomics and other molecular methods. This opens new opportunities for large-scale assembly efforts and the improvement of analysis tools with greater access to multi-omics, microbial reference genomes, and strain-level diversity. To leverage these, we present bioBakery 3, a set of integrated and improved methods for taxonomic, strain-level, functional, and phylogenetic profiling of metagenomes based on the largest set of reference sequences now available. MetaPhlAn 3 and HUMAnN 3 provides more accurate taxonomic and functional potential and activity profiles, respectively. These methods detected novel disease-microbiome links in CRC and IBD cohorts. Strain-level profiling of 4,077 metagenomes with StrainPhlAn 3 and PanPhlAn 3 unravelled the phylogenetic and functional structure of the gut microbe Ruminococcus bromii, previously described by only 15 isolate genomes. Phylogenetic analysis with PhyloPhlAn 3 supports both genomic and metagenomic data, by assigning genomes from isolate sequencing or metagenomic assemblies to species-level genome bins defined on more than 230,000 publically available sequences. It also accurately reconstructs phylogenies at different resolutions (from strain-level to microbial tree-of-life) using maximally informative markers. The bioBakery 3 is open-source and includes documentation, training data, and cloud-deployable reproducible workflows to help researchers deepen the resolution, scale, and accuracy of multi-omic profiling for microbial communities. The ability to use metagenomic assemblies further help to study uncharacterized microbial species not represented by isolate genomes. article: https://elifesciences.org/articles/65088https://cassyni-user-files-prod.s3.amazonaws.com/HWJ1HjyDbvt1BAm4Js4gEz https://cassyni.com/slides/outline/7GK8DPKCYEUa2moTimaynd https://cassyni.com/events/7GK8DPKCYEUa2moTimaynd/abstract https://cassyni-user-files-prod.s3.amazonaws.com/DvjVGw76SAWLskhJzGUo1Y https://cassyni.com/events/7GK8DPKCYEUa2moTimaynd?videoPreview=1 Protective effects of the gut microbial metabolite TMAO upon the brain - there is no such thing as a 'good' or 'bad' metabolitenohttps://cassyni.com/events/7GK8DPKCYEUa2moTimaynd?videoPreview=12022-01-11T12:00:00+00:00828.04Microbiome Virtual International Forum Although our understanding of the importance of the gut microbiota-brain axis in health and disease has increased dramatically over the last decade, our knowledge of the signalling systems that underlie this communication lags behind. Strong evidence points to a role for the various microbial metabolites found in the host circulation and their actions at the principal interface of the brain and the periphery, the blood-brain barrier (BBB). Trimethylamine N-oxide (TMAO) is produced by hepatic oxidation of its gut microbe-derived precursor trimethylamine (TMA) and has been associated with a number of cardiovascular disorders in population-level studies, although its effect(s) on the brain have received less attention. We investigated whether TMAO could modulate the cerebral vasculature and what implications this might have for cognition. We show that physiologically relevant concentrations of TMAO enhance and protect BBB integrity in vitro, acting by mobilisation of the inter-endothelial tight junction regulator annexin A1, while in contrast, TMA impaired BBB function and disrupted tight junction integrity. Notably, beneficial effects of TMAO were replicated in vivo, with its administration reversing BBB impairment induced by either acute or chronic administration of lipopolysaccharide (LPS). This protective effect was consequential for brain function, with long-term TMAO administration via the drinking water preventing LPS-induced recognition memory impairment. Further examination revealed that TMAO prevented LPS-induced glial activation in the entorhinal cortex, a key area for recognition memory. Together, these data identify TMAO as a significant actor in the gut-brain axis, and indicate beneficial effects upon both the brain’s defensive systems and cognitive function – emphasising the importance of dose in studying microbial metabolites. This broadens the range of mediators involved in gut microbe-brain communication, and reinforces the BBB as a significant interface in this axis. As circulating TMAO is ultimately derived from dietary choline, these changes may help explain the well-known beneficial effects of consumption of a seafood-rich diet upon the brain and could have implications for neurological conditions such as dementia.https://cassyni-user-files-prod.s3.amazonaws.com/DvjVGw76SAWLskhJzGUo1Y https://cassyni.com/slides/outline/qBUhsCRiCPVduZE7rbBoB https://cassyni.com/events/qBUhsCRiCPVduZE7rbBoB/abstract https://cassyni-user-files-prod.s3.amazonaws.com/9yYeuTvtvW5ZVrLQuy2aer https://cassyni.com/events/qBUhsCRiCPVduZE7rbBoB?videoPreview=1 Extending Association Rule Mining to Microbiome Pattern Analysis: Tools and Guidelines to Support Real Applicationsnohttps://cassyni.com/events/qBUhsCRiCPVduZE7rbBoB?videoPreview=12022-03-08T11:00:00+00:0065.64Microbiome Virtual International Forum Boosted by the exponential growth of microbiome-based studies, analyzing microbiome patterns is now a hot-topic, finding different fields of application. In particular, the use of machine learning techniques is increasing in microbiome studies, providing deep insights into microbial community composition. In this context, in order to investigate microbial patterns from 16S rRNA metabarcoding data, we explored the effectiveness of Association Rule Mining (ARM) technique, a supervised-machine learning procedure, to extract patterns (in this work, intended as groups of species or taxa) from microbiome data. ARM can generate huge amounts of data, making spurious information removal and visualizing results challenging. Our work sheds light on the strengths and weaknesses of pattern mining strategy into the study of microbial patterns, in particular from 16S rRNA microbiome datasets, applying ARM on real case studies and providing guidelines for future usage. Our results highlighted issues related to the type of input and the use of metadata in microbial pattern extraction, identifying the key steps that must be considered to apply ARM consciously on 16S rRNA microbiome data. To promote the use of ARM and the visualization of microbiome patterns, specifically, we developed microFIM (microbial Frequent Itemset Mining), a versatile Python tool that facilitates the use of ARM integrating common microbiome outputs, such as taxa tables. microFIM implements interest measures to remove spurious information and merges the results of ARM analysis with the common microbiome outputs, providing similar microbiome strategies that help scientists to integrate ARM in microbiome applications. With this work, we aimed at creating a bridge between microbial ecology researchers and ARM technique, making researchers aware about the strength and weaknesses of association rule mining approach. Link to OA paper: https://www.frontiersin.org/articles/10.3389/fbinf.2021.794547/fullhttps://cassyni-user-files-prod.s3.amazonaws.com/9yYeuTvtvW5ZVrLQuy2aer https://cassyni.com/slides/outline/EBParxNYgeEMXao36D9uwK https://cassyni.com/events/EBParxNYgeEMXao36D9uwK/abstract https://cassyni-user-files-prod.s3.amazonaws.com/RHcmE2UH8LJpWhdJm1AuKL https://cassyni.com/events/EBParxNYgeEMXao36D9uwK?videoPreview=1 Human Milk Oligosaccharide Utilization in Intestinal Bifidobacteria is Governed by a Global Transcriptional Regulator NagRnohttps://cassyni.com/events/EBParxNYgeEMXao36D9uwK?videoPreview=12022-06-15T13:00:00+00:00598.0Microbiome Virtual International Forum Bifidobacterium longum subsp. infantis (B. infantis) is a prevalent beneficial bacterium colonizing the human neonatal gut. Decreased abundance of B. infantis contributes to the development of severe acute malnutrition (SAM) in children from the least developing countries. Therapeutic approaches for treating SAM involve using human milk oligosaccharides (HMOs) as dietary additions (prebiotics) to stimulate the growth of B. infantis and confer multiple health benefits to malnourished children. However, the rational selection of HMO-based prebiotics is hampered by the incomplete knowledge of regulatory mechanisms governing HMO utilization in this bacterium. A bioinformatic regulon reconstruction approach used in this study implicated NagR, a transcription factor from the ROK family, as a negative global regulator of genomic loci encoding lacto-N-biose/galacto-N-biose (LNB/GNB), lacto-N-tetraose (LNT), and lacto-N-neotetraose (LNnT) utilization pathways in B. infantis. This conjecture was corroborated by transcriptome profiling upon nagR genetic inactivation and experimental assessment of binding of recombinant NagR to predicted DNA operators. The latter approach also implicated N-acetylglucosamine (GlcNAc), a universal intermediate of LNT and LNnT catabolism, and its phosphorylated derivatives as plausible NagR effectors. The elucidated regulatory network appears optimally adapted to simultaneous utilization of multiple HMOs, providing a rationale to add HMO mixtures (rather than individual components) into infant formulas to restore B. infantis levels in malnourished children.https://cassyni-user-files-prod.s3.amazonaws.com/RHcmE2UH8LJpWhdJm1AuKL https://cassyni.com/slides/outline/Gedc6NcAsvzqtXGbdu4YfF https://cassyni.com/events/Gedc6NcAsvzqtXGbdu4YfF/abstract https://cassyni-user-files-prod.s3.amazonaws.com/TGDBQm4NtAXDCeoko9u1Vg https://cassyni.com/events/Gedc6NcAsvzqtXGbdu4YfF?videoPreview=1 A guided tour into genomic contamination detectionnohttps://cassyni.com/events/Gedc6NcAsvzqtXGbdu4YfF?videoPreview=12022-10-18T13:00:00+00:00624.04Microbiome Virtual International Forum Nowadays, genomes constitute the basis of many research endeavors. This is especially true since the decrease of sequencing cost has led to an explosion of the number of genomes in public repositories. Estimating the amount of contamination, i.e. the inclusion of unwanted DNA in genomic materials, of this deluge of data has become a field in itself, with numerous algorithms now available and an increasing rate of publication over the years. As newly released tools do not simply replace older ones, but have their own scope, it becomes difficult for scientists to efficiently determine which tool to use in their study. Recently, we have published an overview of the main characteristics and applicability of 18 algorithms dedicated to the estimation of genomic contamination. For instance, the conceptual differences between database-free tools and those associated with a reference database have an effect on detection sensitivity, as do the difference between genomewide and marker-based methods. Beyond this typology of tools, we present here a new analysis designed to compare algorithms on a large simulated dataset derived from empirical data. This protocol, dubbed CRACOT for CRitical Assessment of COntamination detection at multiple Taxonomic levels, reveals both under- and over-detection by even the most commonly used algorithms, with simulated contamination events ranging from inter-phylum to inter-species.https://cassyni-user-files-prod.s3.amazonaws.com/TGDBQm4NtAXDCeoko9u1Vg https://cassyni.com/slides/outline/9EuYQ7uJJ4hL8V5h5jSvDB https://cassyni.com/events/9EuYQ7uJJ4hL8V5h5jSvDB/abstract https://cassyni-user-files-prod.s3.amazonaws.com/P4hYWx4R9mp1aVhX9Gihcz https://cassyni.com/events/9EuYQ7uJJ4hL8V5h5jSvDB?videoPreview=1 mEnrich-seq: Methylation-guided enrichment sequencing of bacterial taxa of interest from microbiomenohttps://cassyni.com/events/9EuYQ7uJJ4hL8V5h5jSvDB?videoPreview=12022-12-14T14:00:00+00:00608.04Microbiome Virtual International Forum Metagenomics has enabled the comprehensive study of microbiomes. However, many applications would benefit from a method that can sequence specific bacterial taxa of interest (pathogens, beneficial microbes, or low-abundance taxa), but not the vast background of other taxa in a microbiome sample. To address this need, we developed mEnrich-seq, a method that can enrich taxa of interest from metagenomic DNA before sequencing. The core idea is to exploit the self vs. non-self genome differentiation provided by natural bacterial DNA methylation and rationally choose methylation-sensitive restriction enzymes (REs), individually or in combination, to deplete host DNA and most background microbial DNA while enriching bacterial taxa of interest. This core idea is integrated with library preparation procedures in a way that only non-digested DNA libraries are sequenced. We performed in-depth evaluations of mEnrich-seq and demonstrated its use in several applications to enrich (up to 117-fold) genomic DNA of pathogenic or beneficial bacteria from human urine and fecal samples, including several species that are hard to culture or of low abundance. We also assessed the broad applicability of mEnrich-seq and found that 3130 (68.03%) of the 4601 strains with mapped methylomes to date can be targeted by at least one commercially available RE, representing 54.78% of the species examined in this analysis. mEnrich-seq provides microbiome researchers with a versatile and cost-effective approach for selective sequencing of diverse taxa of interest directly from the microbiome. Link to OA paper: https://www.biorxiv.org/content/10.1101/2022.11.07.515285v1https://cassyni-user-files-prod.s3.amazonaws.com/P4hYWx4R9mp1aVhX9Gihcz https://cassyni.com/events/5HkL9HEzBmBuVJKQyBoKEu/seminar/qa https://cassyni.com/slides/outline/5HkL9HEzBmBuVJKQyBoKEu https://cassyni.com/events/5HkL9HEzBmBuVJKQyBoKEu/abstract https://cassyni-user-files-prod.s3.amazonaws.com/GKkVFHXtoyQ7BGYu4qXC9t https://cassyni.com/slides/outline/Q4PHuFpvsAEQXaVTtLrihs https://cassyni.com/events/Q4PHuFpvsAEQXaVTtLrihs/abstract https://cassyni-user-files-prod.s3.amazonaws.com/58Yxrqmm8sPg1gdrJMZJvS https://cassyni.com/events/Q4PHuFpvsAEQXaVTtLrihs?videoPreview=1 Expanding the human gut microbiome atlas of Africanohttps://cassyni.com/events/Q4PHuFpvsAEQXaVTtLrihs?videoPreview=12024-05-21T15:00:00+00:00691.16Microbiome Virtual International Forum Population studies are crucial in understanding the complex interplay between the gut microbiome and geographical, lifestyle, genetic, and environmental factors. However, populations from low- and middle-income countries, which represent ∼84% of the world population, have been excluded from large-scale gut microbiome research. Here, we present the AWI-Gen 2 Microbiome Project, a cross-sectional gut microbiome study sampling 1,803 women from Burkina Faso, Ghana, Kenya, and South Africa. By intensively engaging with communities that range from rural and horticultural to urban informal settlements and post-industrial, we capture population diversity that represents a far greater breadth of the world’s population. Using shotgun metagenomic sequencing, we find that study site explains substantially more microbial variation than disease status. We identify taxa with strong geographic and lifestyle associations, including loss of Treponema and Cryptobacteroides species and gain of Bifidobacterium species in urban populations. We uncover a wealth of prokaryotic and viral novelty, including 1,005 new bacterial metagenome-assembled genomes, and identify phylogeography signatures in Treponema succinifaciens. Finally, we find a microbiome signature of HIV infection that is defined by several taxa not previously associated with HIV, including Dysosmobacter welbionis and Enterocloster sp. This study represents the largest population-representative survey of gut metagenomes of African individuals to date, and paired with extensive clinical biomarkers, demographic data, and lifestyle information, provides extensive opportunity for microbiome-related discovery and research.https://cassyni-user-files-prod.s3.amazonaws.com/58Yxrqmm8sPg1gdrJMZJvS https://cassyni.com/slides/outline/K7uFSRMgUahP8Un7ss9iyj https://cassyni.com/events/K7uFSRMgUahP8Un7ss9iyj/abstract https://cassyni-user-files-prod.s3.amazonaws.com/HkjJGbrXS6rxbsn4fk23GS https://cassyni.com/events/K7uFSRMgUahP8Un7ss9iyj?videoPreview=1 The role of the gut microbiota in shaping responses to vaccinationnohttps://cassyni.com/events/K7uFSRMgUahP8Un7ss9iyj?videoPreview=12023-02-15T10:00:00+00:00484.04Microbiome Virtual International Forum Global vaccination programs have been enormously successful, dramatically reducing the rates of vaccine-preventable diseases. However, for reasons that are poorly understood, these responses are highly variable between individuals. It is becoming increasingly apparent that the composition and function of the gut microbiota is a critical factor modulating immune responses to vaccination, and when the gut microbiota is disrupted, such as with antibiotic exposure, it may lead to suboptimal vaccine responses (e.g. lower antibody titres). At the Lynn Systems Immunology group we use multi-omic technologies to study the relationship between the gut microbiota and vaccine responses in both humans and preclinical murine models. Here, I will report on findings from the Antibiotics and Immune Responses (AIR) study which followed 170 infants for the first 15 months of life to assess how early life antibiotic exposure shapes the composition of the gut microbiota, immune function and responses to scheduled infant vaccinations.https://cassyni-user-files-prod.s3.amazonaws.com/HkjJGbrXS6rxbsn4fk23GS https://cassyni.com/slides/outline/VVWwQmwhhCKoez5Fty6cfF https://cassyni.com/events/VVWwQmwhhCKoez5Fty6cfF/abstract https://cassyni-user-files-prod.s3.amazonaws.com/PFkq9jo7VQz9ZW8ohA9kk6 https://cassyni.com/events/VVWwQmwhhCKoez5Fty6cfF?videoPreview=1 Human milk variation is shaped by maternal genetics and impacts the infant gut microbiomenohttps://cassyni.com/events/VVWwQmwhhCKoez5Fty6cfF?videoPreview=12023-06-21T10:00:00+00:00704.04Microbiome Virtual International Forum Human milk is a complex mix of nutritional and bioactive components that provide complete nutrition for the infant. However, we lack a systematic knowledge of the factors shaping milk composition and how milk variation influences infant health. Here, we used multi-omic profiling to characterize interactions between maternal genetics, milk gene expression, milk composition, and the infant fecal microbiome in 242 exclusively breastfeeding mother-infant pairs. We identified 487 genetic loci harboring variants associated with milk cell gene expression unique to the lactating mammary gland. Genetic effects on milk gene expression included genes with roles in the biosynthesis of specific human milk oligosaccharides (HMO), including a genetic variant that increases the expression of the gene GCNT3 in milk and is also associated with increased concentration of the HMO FLNH. Integrative analyses uncovered connections between milk gene expression and infant gut microbiome, including an association between the expression of inflammation-related genes with IL-6 concentration in milk and the abundance of Bifidobacteria in the infant gut. Our results show how an improved understanding of the genetics and genomics of human milk connects lactation biology with maternal and infant health.https://cassyni-user-files-prod.s3.amazonaws.com/PFkq9jo7VQz9ZW8ohA9kk6 https://cassyni.com/slides/outline/S2yi5zR2czTAdHmhFJif8R https://cassyni.com/events/S2yi5zR2czTAdHmhFJif8R/abstract https://cassyni-user-files-prod.s3.amazonaws.com/9m8BncRbSqJ83DvkD8NFrN https://cassyni.com/events/S2yi5zR2czTAdHmhFJif8R?videoPreview=1 URANOS-2.0: Improved performance, enhanced portability, and model extension towards exascale computing of high-speed engineering flowsnohttps://cassyni.com/events/S2yi5zR2czTAdHmhFJif8R?videoPreview=12024-08-29T12:00:00+00:001358.04Computer Physics CommunicationsWe present URANOS-2.0, the second major release of our massively parallel, GPU-accelerated solver for compressible wall flow applications. This latest version represents a significant leap forward in our initial tool, which was launched in 2023, and has been specifically optimized to take full advantage of the opportunities offered by the cutting-edge pre-exascale architectures available within the EuroHPC JU. In particular, URANOS-2.0 emphasizes portability and compatibility improvements with the two top-ranked supercomputing architectures in Europe: LUMI and Leonardo. These systems utilize different GPU architectures, AMD and NVIDIA, respectively, which necessitates extensive efforts to ensure seamless usability across their distinct structures. In pursuit of this objective, the current release adheres to the OpenACC standard. This choice not only facilitates efficient utilization of the full potential inherent in these extensive GPU-based architectures but also upholds the principles of vendor neutrality, a distinctive characteristic of URANOS solvers in the CFD solvers' panorama. However, the URANOS-2.0 version goes beyond the goals of improving usability and portability; it introduces performance enhancements and restructures the most demanding computational kernels. This translates into a $2\times$ speedup over the same architecture. %and a more than $5\times$ speedup if we compare the first NVIDIA-V100-tuned version with the actual one running over NVIDIA H100 GPUs. In addition to its enhanced single-GPU performance, the present solver release demonstrates very good scalability in multi-GPU environments. URANOS-2.0, in fact, achieves strong scaling efficiencies of over 80\% across 64 compute nodes (256 GPUs) for both LUMI and Leonardo. Furthermore, its weak scaling efficiencies reach approximately 95\% and 90\% on LUMI and Leonardo, respectively, when up to 256 nodes (1024 GPUs) are considered. These significant performance advancements position URANOS-2.0 as a state-of-the-art supercomputing platform tailored for compressible wall turbulence applications, establishing the solver as an integrated tool for various aerospace and energy engineering applications, which can span from direct numerical simulations, wall-resolved large eddy simulations, up to most recent wall-modeled large eddy simulations.https://cassyni-user-files-prod.s3.amazonaws.com/9m8BncRbSqJ83DvkD8NFrN https://cassyni.com/slides/outline/UWDjKQeepHDezEFFnzdHrM https://cassyni.com/events/UWDjKQeepHDezEFFnzdHrM/abstract https://cassyni-user-files-prod.s3.amazonaws.com/WZBU1Z5krT6BVvM6SWVJEz https://cassyni.com/events/UWDjKQeepHDezEFFnzdHrM?videoPreview=1 Urban Analytics Series: Studying Cities and People Using Digital Footprintsnohttps://cassyni.com/events/UWDjKQeepHDezEFFnzdHrM?videoPreview=12024-09-23T02:00:00+00:001235.76The University of Auckland Business SchoolIn this seminar, Dr. Federico Botta from the University of Exeter (UoE) will present on his latest research on studying cities and people using digital footprints. His recent publications include COVID-19 is linked to changes in the time-space dimension of human mobility published in Nature Human Behaviour, Modelling urban vibrancy with mobile phone and OpenStreetMap data published in PLoS ONE, and Measuring the size of a crowd using Instrgram published in Environment and Planning B.https://cassyni-user-files-prod.s3.amazonaws.com/WZBU1Z5krT6BVvM6SWVJEz https://cassyni.com/slides/outline/XxUjVu2Trsq5ENM2W5WZMF https://cassyni.com/events/XxUjVu2Trsq5ENM2W5WZMF/abstract https://cassyni-user-files-prod.s3.amazonaws.com/HoA9TuvcXKAdXoiE35yhzN https://cassyni.com/events/XxUjVu2Trsq5ENM2W5WZMF?videoPreview=1 Limits of using early warning signals for preventing tippingnohttps://cassyni.com/events/XxUjVu2Trsq5ENM2W5WZMF?videoPreview=12025-06-24T10:00:00+00:00751.76NODYSTipping (or sudden transition) from a desirable state to an undesirable one can result in catastrophic changes, affecting natural environments, human societies, and economies. Early warning signals (EWSs) are developed to forewarn such an impending tipping. However, we observe that EWSs detect an impending tipping past bifurcation points when control parameters are varied fast. This questions the applicability of EWSs in preventing tipping. At the same time, the fast rate of change of parameter delays the actual tipping event, thus providing a borrowed stability that offers a window for prevention through swift action. We demonstrate instances of both successful and unsuccessful preventions in a paradigmatic thermoacoustic system. This work highlights the interplay of warning time, choice of prevention action, and rate of variation of parameters in EWS-based prevention of tipping.https://cassyni-user-files-prod.s3.amazonaws.com/HoA9TuvcXKAdXoiE35yhzN https://cassyni.com/slides/outline/SXM5zNuh2qjzqW6nuAWmMo https://cassyni.com/events/SXM5zNuh2qjzqW6nuAWmMo/abstract https://cassyni-user-files-prod.s3.amazonaws.com/FwkkeymHHD2MpR3hUfGqdY https://cassyni.com/events/SXM5zNuh2qjzqW6nuAWmMo?videoPreview=1 Electronics and Cryptography with Fractional Derivative Memristor based 4D Chaotic Flownohttps://cassyni.com/events/SXM5zNuh2qjzqW6nuAWmMo?videoPreview=12025-06-24T10:00:00+00:00840.72NODYSThis research study presents a new tangent-hyperbolic memristive based 4D fractional order nonlinear chaotic system. With three memristors and different fractional order index, complex chaotic system is formed which modify the trajectories and increase the complexity. The basic key proposal is to investigate the novel 4D chaotic system, attached with tangent hyperbolic memristors, explore for different values of Caputo fractional derivative, probed with different graphical illustrations, and analysed with mathematical tools like Lyapunov exponents and bifurcation technique. Owing to the distinctive nonlinear chaotic features of the memristor fused with fractional calculus, different random data are generated, which are utilized to execute encryption. Novel algorithms of steganography and watermarking is presented along with the correct and incorrect keys demonstration to secure the data. A complex electronic circuity is designed on MULTISIM and presented to compliment the theoretical outcomes with experimental results.https://cassyni-user-files-prod.s3.amazonaws.com/FwkkeymHHD2MpR3hUfGqdY https://cassyni.com/slides/outline/T1zh34ZDUJJ3qGdgVboZd7 https://cassyni.com/events/T1zh34ZDUJJ3qGdgVboZd7/abstract https://cassyni-user-files-prod.s3.amazonaws.com/9XKu46MTaFq3QMT1wa2GGe https://cassyni.com/events/T1zh34ZDUJJ3qGdgVboZd7?videoPreview=1 Simplification method for the dynamic model of the giant magnetostrictive actuatornohttps://cassyni.com/events/T1zh34ZDUJJ3qGdgVboZd7?videoPreview=12025-06-24T11:00:00+00:00811.32NODYSTo simplify the model of a giant magnetostrictive actuator, we propose the approach of employing the basic magnetization instead of the loop, and considering the hysteresis loss by compensating the mechanical damping. From computations, the simplification with compensation realizes similar amplitude and loop area to the initial complex model.https://cassyni-user-files-prod.s3.amazonaws.com/9XKu46MTaFq3QMT1wa2GGe https://cassyni.com/slides/outline/5n7i3fjebcUjhWeWd3bRUH https://cassyni.com/events/5n7i3fjebcUjhWeWd3bRUH/abstract https://cassyni-user-files-prod.s3.amazonaws.com/BFbWiV7o7MmPFoyuixA7BC https://cassyni.com/events/5n7i3fjebcUjhWeWd3bRUH?videoPreview=1 Nonlinear Dynamic Modeling of Duffing Oscillators Using Fourier Neural Operatorsnohttps://cassyni.com/events/5n7i3fjebcUjhWeWd3bRUH?videoPreview=12025-06-24T11:00:00+00:00695.52NODYSLearning solution operators (i.e., mappings from input to output functions) have emerged as a powerful strategy in Scientific Machine Learning (SciML) for modeling complex systems. This approach enables fast predictions across a range of inputs (e.g., varying forcing or initial conditions) without repeated simulations. In this context, Fourier Neural Operators (FNOs) are at the forefront of data-driven operator learning. However, their generalization can be limited, especially for complex or out-of-distribution inputs. This work explores the integration of physical knowledge into a Physics-Informed FNO (PI-FNO) framework to model the dynamics of a Duffing oscillator under harmonic excitation. Focusing on Duffing systems with potentially chaotic responses, it is assessed how embedding physical constraints influences the learned solution space compared to a standard FNO. Additionally, two-stage training protocols are investigated to determine effective strategies for enhancing the robustness, accuracy, and generalization of neural operators in modeling highly nonlinear and possibly chaotic dynamical systems.https://cassyni-user-files-prod.s3.amazonaws.com/BFbWiV7o7MmPFoyuixA7BC https://cassyni.com/slides/outline/DgWzuEbw2JGQ1ZAVP2a84V https://cassyni.com/events/DgWzuEbw2JGQ1ZAVP2a84V/abstract https://cassyni-user-files-prod.s3.amazonaws.com/XyHScEtMiaCMcrH1ArRuJ6 https://cassyni.com/events/DgWzuEbw2JGQ1ZAVP2a84V?videoPreview=1 Investigation of Neoclassical Tearing Mode Detection by ECE Radiometry in Tokamak Reactors via Asymptotic Matching Techniquesnohttps://cassyni.com/events/DgWzuEbw2JGQ1ZAVP2a84V?videoPreview=12025-07-17T15:00:00+00:001944.96Journal of Plasma PhysicsNeoclassical tearing modes (NTMs) are the leading cause of disruptions in conventional fusion-relevant tokamak discharges. NTMs can be stabilized by driving a toroidal current that is localized at the magnetic flux-surface in the plasma at which the mode reconnects magnetic flux by means of externally injected electron cyclotron waves. The keys to the success of this method are the early detection of the NTM, and an accurate determination of the location of the reconnecting surface. The most promising method of mode detection and accurate location of the reconnecting surfaces are by means of electron cyclotron emission (ECE) from the plasma. Existing calculations of the ECE signals likely to be produced by an NTM are surprisingly crude. This talk will describe how an asymptotic matching code can be used to produce a much more realistic synthetic ECE signal. The code works by splitting the plasma into two regions. In the outer region, the NTM is basically an ideal mode that displaces magnetic flux-surfaces without changing their topology. In the inner region, which is localized in the vicinity of the reconnecting surface, the NTM generates a radially asymmetric magnetic island chain. The solutions in the inner and outer regions must be asymptotically matched to one another to produce a global solution.https://cassyni-user-files-prod.s3.amazonaws.com/XyHScEtMiaCMcrH1ArRuJ6 https://cassyni.com/slides/outline/ADymaT5Fx6PkyrrvjNCAXf https://cassyni.com/events/ADymaT5Fx6PkyrrvjNCAXf/abstract https://cassyni-user-files-prod.s3.amazonaws.com/T2oQ9QR7KzfLDkZfANiuZx https://cassyni.com/events/ADymaT5Fx6PkyrrvjNCAXf?videoPreview=1 Predicting Fusion Ignition at the National Ignition Facility with Machine Learningnohttps://cassyni.com/events/ADymaT5Fx6PkyrrvjNCAXf?videoPreview=12024-06-06T15:00:00+00:003232.56Journal of Plasma PhysicsOn December 5, 2022, 192 laser beams at the National Ignition Facility focused 2.05 megajoules of energy onto a capsule of frozen hydrogen fuel. In less time than it takes light to travel 10 feet, the laser crushed the capsule to smaller than the width of a human hair, vaulting the fuel to temperatures and densities exceeding those found in the sun. Under these extreme conditions, the fuel ignited and produced 3.15 megajoules of energy, making it the first experiment to ever achieve net energy gain from nuclear fusion. After several decades of research, fusion breakeven at NIF brings humanity one step closer to the dream of limitless carbon-free, safe, clean energy. Yet, the shot that finally ushered in the Fusion Age was not actually that surprising. Prior to the experiment, our physics team used a machine learning model to predict the outcome of the experiment. The model, which blends supercomputer simulations with experimental data, indicated that ignition was the most likely outcome for this shot. In this talk, we discuss the breakthrough experiment, nuclear fusion, and how we used machine learning to predict that this experiment would demonstrate one of the biggest scientific achievements of our lifetime. LLNL-ABS-844080.https://cassyni-user-files-prod.s3.amazonaws.com/T2oQ9QR7KzfLDkZfANiuZx https://cassyni.com/slides/outline/ChDnosJt9PAFLoLVH46oFb https://cassyni.com/events/ChDnosJt9PAFLoLVH46oFb/abstract https://cassyni-user-files-prod.s3.amazonaws.com/MbfkdtJLVxZtR8DeEebHLJ https://cassyni.com/events/ChDnosJt9PAFLoLVH46oFb?videoPreview=1 Foams as a Pathway to Energy from Inertial Fusionnohttps://cassyni.com/events/ChDnosJt9PAFLoLVH46oFb?videoPreview=12024-12-19T16:00:00+00:003201.32Journal of Plasma PhysicsThe perspective of reaching ignition using high power lasers such as the National Ignition Facility (NIF) in the USA or the Laser MégaJoule (LMJ) in France is significantly closer today thanks to technical advances (e.g. the ability to manufacture high-density carbon shells doped with high-Z elements) and to an increased knowledge of the underlying fundamental physics. Following the same logic, a eurofusion project (FOPIFE) has been funded to study the physics of nano-structured medium/foams in a fusion framework. Foams are envisioned for various applications: increase laser to matter coupling, reduce laser imprint, enable high repetition rate implosion at reduced cost. In this presentation, I will go over the various challenges and benefits associated to the use of foams for Inertial Fusion Energy and the effort in Europe to answer these questions.https://cassyni-user-files-prod.s3.amazonaws.com/MbfkdtJLVxZtR8DeEebHLJ https://cassyni.com/events/M6Ggi7ph1XVxecPMdUNJ77/abstract https://cassyni-user-files-prod.s3.amazonaws.com/H4epo6Grfov1T1U6esFLfg https://cassyni.com/slides/outline/PZWhwY4KCpGT1YrvBAGvq3 https://cassyni.com/events/PZWhwY4KCpGT1YrvBAGvq3/abstract https://cassyni-user-files-prod.s3.amazonaws.com/QZZNuzBV8htX8GkYCyaAt6 https://cassyni.com/events/PZWhwY4KCpGT1YrvBAGvq3?videoPreview=1 Improvement of confinement in tokamaks by a weakening the poloidal magnetic field at the boundary, invariants, and attractorsnohttps://cassyni.com/events/PZWhwY4KCpGT1YrvBAGvq3?videoPreview=12022-03-31T15:00:00+00:002806.68Journal of Plasma PhysicsDensity profiles of tokamaks are enigmatically peaked and can be described as a turbulent attractor defined by a conservation law, namely, the plasma is frozen in the poloidal magnetic field. The profiles aka Turbulent EquiPartition are accurately described by a simple formula nv=const where v is the specific poloidal volume. The formula predicts that density and temperature at the border will decrease if the v is increased. This can be done in many ways and was observed experimentally before any theory emerged. The first way observed was current rampdown and the latest way was negative triangularity. Since almost all results in tokamaks were obtained experimentally, the theory will be presented briefly as well as several new ways to improve confinement. The theory will include the origin of many plasma and tokamak invariants from the Poincare invariant.https://cassyni-user-files-prod.s3.amazonaws.com/QZZNuzBV8htX8GkYCyaAt6 https://cassyni.com/slides/outline/L6yUckXe8cPoyrZMXVtyJD https://cassyni.com/events/L6yUckXe8cPoyrZMXVtyJD/abstract https://cassyni-user-files-prod.s3.amazonaws.com/K8RjQU4iJfoQ4Bk5gxgecN https://cassyni.com/events/L6yUckXe8cPoyrZMXVtyJD?videoPreview=1 Exploring Novel Properties of Strongly Magnetized Plasmasnohttps://cassyni.com/events/L6yUckXe8cPoyrZMXVtyJD?videoPreview=12022-08-18T15:00:00+00:003638.04Journal of Plasma PhysicsAn often-underappreciated aspect of plasma theory is that it assumes weak magnetization, applying only when the electron gyroradius is much larger than the Debye length. This allows one to ignore the magnetic field at the scale of Coulomb interactions. Here, we use first-principles molecular dynamics simulations and new theoretical methods to explore the properties of strongly magnetized plasmas. A few novel behaviors have been uncovered. One is that the friction force on a test ion moving through a strongly magnetized plasma shifts to obtain components that act perpendicular to its velocity. These components cause qualitative changes to the average trajectory of the ion, such as changing its gyroradius and gyrofrequency in non-intuitive ways. They also translate to qualitative changes in macroscopic material properties of the plasma, such as the electrical conductivity, viscosity, and energy relaxation rates. Although strongly magnetized plasmas are not the norm, they do arise in several contexts, including non-neutral plasmas, antimatter traps, high magnetic field approaches to fusion energy, and in dense astrophysical objects such as magnetars. These results suggest that unexpected behaviors arise in these systems, and it motivates potential applications that make use of these novel properties.https://cassyni-user-files-prod.s3.amazonaws.com/K8RjQU4iJfoQ4Bk5gxgecN https://cassyni.com/events/WUbAb77fME2EWMrVYbqryj/abstract https://cassyni.com/slides/outline/WyEmdnmBngaHW8PP938fF3 https://cassyni.com/events/WyEmdnmBngaHW8PP938fF3/abstract https://cassyni-user-files-prod.s3.amazonaws.com/GAEFsSWpExJEV9pRar82Yn https://cassyni.com/events/WyEmdnmBngaHW8PP938fF3?videoPreview=1 The helicity barrier: how low-frequency turbulence triggers high-frequency heating of the solar windnohttps://cassyni.com/events/WyEmdnmBngaHW8PP938fF3?videoPreview=12021-11-18T16:00:00+00:003000.32Journal of Plasma PhysicsTurbulence, as the agent responsible for converting mechanical into thermal energy, controls the thermodynamic properties of many astrophysical plasmas. For low collisionality plasmas, a wide array of channels are available — ions might be more heated than electrons (or vice versa), or the heating may be anisotropic with respect to the magnetic field. In the solar corona and fast solar wind, which are heated strongly above the Sun’s surface by the liberation of energy in magnetic fields, observations show that heating is perpendicular, affecting heavy ions more than protons, and protons more than electrons. For low-frequency Alfvénic-turbulence models, which are a leading candidate to explain the fast-wind’s properties, this detailed heating partition has been a puzzle: theories predict a variety of outcomes, with electron heating dominating in the highly anisotropic, low-beta limit that seems most relevant to coronal conditions. Another theory, involving resonance with high-frequency ion-cyclotron waves (ICWs), naturally explains details of the heating rates, but it has proved difficult to explain the source of ICWs. In this talk, I will explain how a bizarre effect in plasma turbulence — termed the “helicity barrier” — may resolve this conundrum. This barrier halts the flux of turbulent energy to the smallest scales when the stirring at large scales is dominated by waves propagating in one direction (imbalanced). This inhibits electron heating, causing the energy in magnetic fields to build up in time until it generates ICWs, thus preferentially heating ions instead. In our 6D hybrid-kinetic simulations, the resulting turbulence bears detailed resemblance to a wide array of in-situ measurements from the solar wind, capturing the steep “transition range,” observed magnetic-helicity signatures, and key features of the ion distribution function. Based on the predicted dependence of the ion-to-electron heating ratio on imbalance, we suggest that, combined with expansion, the effect could play an important role in regulating global features of the solar wind such as its bimodal speed distribution.https://cassyni-user-files-prod.s3.amazonaws.com/GAEFsSWpExJEV9pRar82Yn https://cassyni.com/events/RY788GeQxeVD7G99Y88sFb/abstract https://cassyni.com/events/6GpZKcQwqntLLg6ecpYZZP/abstract https://cassyni.com/events/8k4aZ2ea35ephcaDAWTCHK/abstract https://cassyni-user-files-prod.s3.amazonaws.com/RsraPAR3AmqhesJHWNUC9U https://cassyni.com/slides/outline/BCEwSXJWvfE2CpqAXTfpPP https://cassyni.com/events/BCEwSXJWvfE2CpqAXTfpPP/abstract https://cassyni-user-files-prod.s3.amazonaws.com/M2xaqiDvEKt8MgmpuDvyBt https://cassyni.com/events/BCEwSXJWvfE2CpqAXTfpPP?videoPreview=1 Transradial versus Transfemoral Neuroangiography in a Tertiary Pediatric Hospital – a Propensity Score Matched Studynohttps://cassyni.com/events/BCEwSXJWvfE2CpqAXTfpPP?videoPreview=12025-10-15T09:51:17+00:00553.84Society for Pediatric Interventional Radiology## Introduction To evaluate the feasibility and safety of transradial access (TRA) in comparison to transfemoral access (TFA) for pediatric neurovascular procedures. ## Materials and Methods Retrospective cohort study including 729 pediatric neurovascular procedures performed between January 2020 and December 2024, with 175 TRAs and 540 TFAs. Primary outcomes included technical success and adverse events, while secondary outcomes assessed radiation dose, fluoroscopy time and procedural duration. Propensity score matching (1:1) was applied to adjust for imbalance in baseline covariates. Statistical significance was set at P<.05. ## Results 100 matched pairs of TRA and TFA were analyzed (TRA median age 13.9 [IQR 11.7–15.3] years, 52 females; TFA median age 14.5 [IQR 11.6–16.4] years, 51 females). Technical success rates were similar between TRA and TFA (98% vs 99%, P >.99). TRA was associated with a higher rate of vasospasm (7% vs 1%, P=.03) and a lower rate of hematoma formation (2% vs 9%, P=.03). Fluoroscopy time was longer in the TRA group (19.4 vs 8.8 minutes, P <0.001), but the radiation dose and procedural time were comparable between both groups. Asymptomatic radial artery occlusion (RAO) was detected in 5.1% (9/175) of radial accesses. A sheath-to-artery (S/A) ratio ≥1 was independently associated with RAO (OR 6.13; 95% CI:1.32-28.4; P=.021). ## Discussion TRA is a technically feasible and safe alternative to TFA for pediatric neurovascular procedures. Although vasospasm is more frequent, TRA reduces hematoma risk and offers comparable procedural outcomes. Pre-procedural US assessment of radial artery and optimization of S/A ratio are important to reducing the risk of RAO.https://cassyni-user-files-prod.s3.amazonaws.com/M2xaqiDvEKt8MgmpuDvyBt https://cassyni.com/slides/outline/CBUuJdZnzrUovmCxvfSPGR https://cassyni.com/events/CBUuJdZnzrUovmCxvfSPGR/abstract https://cassyni-user-files-prod.s3.amazonaws.com/YxJxG1cELvaHthn15uf3t https://cassyni.com/events/CBUuJdZnzrUovmCxvfSPGR?videoPreview=1 Biophysics in Africa: Effect of cyclonically draughted 35-60 kHz synthetic sounds of Odorrana tormota, Delphinapterus leucas, and male Anopheles gambiaenohttps://cassyni.com/events/CBUuJdZnzrUovmCxvfSPGR?videoPreview=12024-09-25T06:00:00+00:002620.52Springer Nature Physics CommunityMalaria, a tropical disease caused by Plasmodium falciparum, is transmitted by the haematophagous mated female Anopheles gambiae. The P. falciparum is reported as the most prevalent malaria parasite responsible for severe morbidity, mortality, and worldwide economic burden. This calls for novel approaches targeting the vector to intervene malaria endemic. Natural and artificial sounds have been used in the study of phonotactic responses in mosquitoes and other insects. Studies have shown negative phonotactic response in mosquitoes for sounds from electronic mosquito repellent (EMR) (40-55 kHz), Odorrana tormota (35-60 kHz) and winded-EMR that yielding 68.99%, 45.88% and 60.70% efficacy respectively. Little has been reported on phonotaxis studies involving use of animal mimicking synthetic sounds generated from natural sounds formants and mated female Anopheles gambiae. Therefore this study established the effect of 35-60 kHz synthetic sounds of Odorrana tormota, Delphinapterus leucas, and male Anopheles gambiae on evoked Spatial Activity Index (SAI) and Protection Index (PI) in tropical mated female Anopheles gambiae. The synthetic ultrasounds of O. tormota, mixed male A. gambiae and O. tormota, and mixed male A. gambiae, O. tormota and D. leucas were generated using Avisoft SASLab Pro version 5.2 and Raven Pro 1.6 from respective natural sounds evoking optimal repellency. Fifty starved mated female A. gambiae were allowed into the fighto-Y bioassay cage containing blood meal and treated with 35-60 kHz sound of O. tormota, mixed male A. gambiae and O. tormota, and mixed male A. gambiae, O. tormota and D. leucas at a time with each bioassay lasting 1,200 s. The number of female A. gambiae that were responsive and landed were determined. The mean SAI in female A. gambie evoked by synthetic sound of O. tormota, mixed sound of the male A. gambiae and O. tormota, and mixed sound of the male A. gambiae, O. tormota, and D. leucas were 0.144, 0.078 and 0.14, respectively. The overall PI evoked by synthetic sound of O. tormota, mixed sound of male A. gambiae and O. tormota, mixed sound of the male A. gambiae, O. tormota, and D. leucas were 46.35%, 39.55%, and 43.20% respectively, which were 33.71%, 40.51% and 36.86 % less than the PI of the 35-60 kHz natural sounds of O. tormota. The 35-60 kHz synthetic sound of O. tormota recorded the greatest PI and SAI processing superior acoustic propagation parameters. Synthesizing sounds of optimal PI does not improve the efficacy in repellency of the mated female A. gambiae. https://cassyni-user-files-prod.s3.amazonaws.com/YxJxG1cELvaHthn15uf3t https://cassyni.com/slides/outline/3HXoL2mV51FNHE4vfPkvdB https://cassyni.com/events/3HXoL2mV51FNHE4vfPkvdB/abstract https://cassyni-user-files-prod.s3.amazonaws.com/NuWUsAdNQL2Xsv4PfCYuY2 https://cassyni.com/events/3HXoL2mV51FNHE4vfPkvdB?videoPreview=1 Intelligent Sports and Health • Series III — New Materials for Sports and Healthnohttps://cassyni.com/events/3HXoL2mV51FNHE4vfPkvdB?videoPreview=12025-09-29T01:00:00+00:007668.0NoneTo promote academic exchanges, [Intelligent Sports and Health(ISH)](https://www.keaipublishing.com/en/journals/intelligent-sports-and-health/) hosts a series of thematic seminars. Renowned experts and active researchers are invited to share their cutting‑edge research outcomes Symposium on “New Materials for Sports and Health” was the 3rd series for this webinar which held on Sep. 29, 2025. Four speakers shared their latest research. https://cassyni-user-files-prod.s3.amazonaws.com/NuWUsAdNQL2Xsv4PfCYuY2 https://cassyni.com/slides/outline/F9BAnKqjp5KGGRvT2eg44V https://cassyni.com/events/F9BAnKqjp5KGGRvT2eg44V/abstract https://cassyni-user-files-prod.s3.amazonaws.com/V8PTSEwZC8UMssJg8i22mk https://cassyni.com/events/F9BAnKqjp5KGGRvT2eg44V?videoPreview=1 Science Advocacy in Action: Superinfection Inhibitionnohttps://cassyni.com/events/F9BAnKqjp5KGGRvT2eg44V?videoPreview=12025-07-21T06:00:00+00:00388.04Journal of VirologyUnderstanding superinfection inhibition offers key insights into how viruses evolve, compete, and interact with their environments. In the featured webinar, Isabella Aquino, Ph.D., M.S., presented her discovery that giant viruses can prevent other viruses from infecting the same host cell—revealing a striking strategy of viral competition. As giant viruses continue to challenge the boundaries of what defines a virus, research like this helps refine core biological concepts. Aquino’s work deepens our understanding of virus-host dynamics and highlights the remarkable complexity of microscopic life. Fueled by curiosity and a drive to explore the unknown, she investigates some of the field’s biggest questions—like just how large and diverse viruses can be, and what that means for the microbial sciences. https://cassyni-user-files-prod.s3.amazonaws.com/V8PTSEwZC8UMssJg8i22mk https://cassyni.com/slides/outline/N5QA7i2RUH3qoF9Ep5bkv1 https://cassyni.com/events/N5QA7i2RUH3qoF9Ep5bkv1/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Pta2hxgGvdfzQKFTnrt2DU https://cassyni.com/events/N5QA7i2RUH3qoF9Ep5bkv1?videoPreview=1 12 Labours Seminar Series (Exemplar Project 1): Pulmonary hypertensionnohttps://cassyni.com/events/N5QA7i2RUH3qoF9Ep5bkv1?videoPreview=12022-10-04T23:00:00+00:003723.48Auckland Bioengineering InstitutePulmonary hypertension (PH) is a debilitating progressive disease characterised by abnormally high pulmonary blood pressures, leading to heart failure and, eventually, death. 12 Labours’ Exemplar Project 1 is focused on uncovering potential diagnostic and treatment strategies via development of patient-specific models that are carefully calibrated to clinical imaging and physiological measurements. Our initial studies will establish a clinical modelling workflow to evaluate response to treatment in a chronic thromboembolic PH patient cohort for whom surgical treatment is an option. This will provide a proof-of-concept imaging/data to modelling platform that we will extend to other PH groups. We also aim to improve diagnosis and phenotyping of PH groups via utilisation of personalised digital models and group-specific biomarkers. In line with this we will discuss our efforts towards accurately modelling the pulmonary system dynamics by creating a reduced order time-domain lumped parameter perfusion model (informed by a 1D frequency domain perfusion model) coupled to a lumped parameter cardiovascular system model. Future work will incorporate systemic control of the cardiovascular system in order to accurately predict the response to clinical treatments and thus provide more detailed information to clinicians. https://cassyni-user-files-prod.s3.amazonaws.com/Pta2hxgGvdfzQKFTnrt2DU https://cassyni.com/events/G9g9nmHu1WFkcatuwxAVQ1/abstract https://cassyni-user-files-prod.s3.amazonaws.com/CrL9KfmoYuM2sMEwsfWW78 https://cassyni.com/slides/outline/BDC7KvpecvijDVBZwUTVfs https://cassyni.com/events/BDC7KvpecvijDVBZwUTVfs/abstract https://cassyni-user-files-prod.s3.amazonaws.com/MEcTHYSZiUB4h4Ye2XeKYA https://cassyni.com/events/BDC7KvpecvijDVBZwUTVfs?videoPreview=1 An experimental approach to analyze aerosol and splatter formations due to a dental procedurenohttps://cassyni.com/events/BDC7KvpecvijDVBZwUTVfs?videoPreview=12022-02-15T15:00:00+00:002628.72Experiments in FluidsThroughout 2020 and beyond, the entire world has observed a continuous increase in the infectious spread of the novel coronavirus (SARS-CoV-2) otherwise known as COVID-19. The high transmission of this airborne virus has raised countless concerns regarding safety measures employed in the working conditions for medical professionals. Specifically, those who perform treatment procedures on patients which intrinsically create mists of fine airborne droplets, i.e., perfect vectors for this and other viruses to spread. The present study focuses on understanding the splatter produced due to a common dentistry technique to remove plaque buildup on teeth. This technique uses a high-speed dentistry instrument, e.g., a Cavitron ultrasonic scaler, to scrape along the surface of a patient’s teeth. This detailed understanding of the velocity and the trajectory of the droplets generated by the splatter will aid in the development of hygiene mechanisms to guarantee the safety of those performing these procedures and people in clinics or hospitals. Optical flow tracking velocimetry (OFTV) method was employed to obtain droplet velocity and trajectory in a two-dimensional plane. Multiple data collection planes were taken in different orientations around a model of adult mandibular teeth. This technique provided pseudo-three-dimensional velocity information for the droplets within the splatter developed from this high-speed dental instrument. These results indicated that within the three-dimensional splatter produced there were high velocities (1–2 m/s) observed directly below the intersection point between the front teeth and the scaler. The splatter formed a cone-shape structure that propagated 10–15 mm away from the location of the scaler tip. From the droplet trajectories, it was observed that high velocity isolated droplets propagate away from the bulk of the splatter. It is these droplets which are concerning for health safety to those performing the medical procedures. Using a shadowgraphy technique, we further characterize the individual droplets’ size and their individual velocity. We then compare these results to previously published distributions. The obtained data can be used as a first step to further examine flow and transport of droplets in clinics/dental offices.https://cassyni-user-files-prod.s3.amazonaws.com/MEcTHYSZiUB4h4Ye2XeKYA https://cassyni.com/slides/outline/J7rEG49hivacWq9H4ZLU85 https://cassyni.com/events/J7rEG49hivacWq9H4ZLU85/abstract https://cassyni-user-files-prod.s3.amazonaws.com/GeL2HqmdJBRChPz4tBKDFt https://cassyni.com/events/J7rEG49hivacWq9H4ZLU85?videoPreview=1 Storage redesign and future plansnohttps://cassyni.com/events/J7rEG49hivacWq9H4ZLU85?videoPreview=12022-09-13T13:25:00+00:001210.8NEKTAR++No abstracthttps://cassyni-user-files-prod.s3.amazonaws.com/GeL2HqmdJBRChPz4tBKDFt https://cassyni.com/slides/outline/Lb6FVUPKvDM6smcqcFF6r1 https://cassyni.com/events/Lb6FVUPKvDM6smcqcFF6r1/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Ej6Hcih3zoPUC122jXfgFg https://cassyni.com/events/Lb6FVUPKvDM6smcqcFF6r1?videoPreview=1 What Determines Audit Fees? A Machine Learning Analysisnohttps://cassyni.com/events/Lb6FVUPKvDM6smcqcFF6r1?videoPreview=12022-10-06T22:00:00+00:005483.48SACLWe argue that diversity in audit fee models significantly complicates the task of justifying the inclusion of additional specific variables on both theoretical and empirical grounds. The absence of an accepted, robust baseline model also raises concerns about p-hacking. Using machine learning techniques, we narrow the set of fee determinants from a pool of more than 300 possible covariates to 12 variables that possess strong explanatory power for audit fees. Using this baseline model, we show that some prior results identifying “novel” additions to audit fee models are sensitive to the selection of the covariates typically characterized as controls. Our model offers researchers a simple-to-implement and authoritative fee model against which additional hypothesized determinants can be fairly assessed. Paper link [here:](https://web.tresorit.com/l/TU1NA#ukIF_F2GFUwrCLah76Uv4Q)https://cassyni-user-files-prod.s3.amazonaws.com/Ej6Hcih3zoPUC122jXfgFg https://cassyni.com/slides/outline/Uz7XH6PFNzm636yJg6aA4u https://cassyni.com/events/Uz7XH6PFNzm636yJg6aA4u/abstract https://cassyni-user-files-prod.s3.amazonaws.com/SHPSeHYvDrEnzuiGGNZH2v https://cassyni.com/events/Uz7XH6PFNzm636yJg6aA4u?videoPreview=1 Unsteadiness of Shock Wave / Turbulent Boundary Layer Interactionsnohttps://cassyni.com/events/Uz7XH6PFNzm636yJg6aA4u?videoPreview=12022-03-04T16:00:00+00:003144.32Journal of Fluid MechanicsShock wave / boundary layer interactions are an important feature of high-speed flow that occur in supersonic and hypersonic aircraft inlets, aircraft control surfaces, missile base flows, nozzles, and rotating machinery. These interactions are often associated with severe boundary layer separation, which is highly unsteady, and exhibits high fluctuating pressure and heat loads. The unsteady motions are characterized by a wide range of frequencies, including low-frequency motions that are about two orders of magnitude lower than the integral-scale fluctuations in the upstream boundary layer. The low-frequency motions are particularly problematic for aircraft structures as they can excite high-amplitude vibration of thin panels, which can lead to fatigue and failure. In this seminar, we will discuss experimental research on various types of shock wave / boundary layer interactions that we have conducted over the past 20 years. The discussion will focus on the use of high-speed PIV and pressure sensitive paint to investigate the physical mechanisms that drive the separated flow unsteadiness in 2D and 3D interactions.https://cassyni-user-files-prod.s3.amazonaws.com/SHPSeHYvDrEnzuiGGNZH2v https://cassyni.com/slides/outline/XTMYWWcsaHXaQ3SsDnUnnq https://cassyni.com/events/XTMYWWcsaHXaQ3SsDnUnnq/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Sn33gyCSfJnqzgF9ror5JE https://cassyni.com/events/XTMYWWcsaHXaQ3SsDnUnnq?videoPreview=1 Living Droplets Get to Worknohttps://cassyni.com/events/XTMYWWcsaHXaQ3SsDnUnnq?videoPreview=12022-12-02T16:00:00+00:003622.44Journal of Fluid MechanicsDroplets of simple liquids, like oil and water, are essential engineering fluids. Classically, we use droplets to deliver material, transport heat, and control chemical reactions. Thanks to microfluidic technology, a wealth of new applications has emerged in recent years. Evolution, however, beat us to it. For more than a billion years, living cells have been producing microscopic droplets in the cytoplasm. These droplets have very different chemical compositions and mechanical properties than the simple liquids we encounter daily. They are thought to play an essential role in organizing chemical reactions in the cytoplasm. Using some simplified in vitro systems, I will highlight the essential physical properties of such fluids. After describing key aspects of their bulk and interfacial thermodynamics, I will demonstrate three mechanisms that enable these droplets to do useful mechanical work. Quasistatically, droplets’ interfacial tension can deform other compliant objects. Near equilibrium, the free energy of condensation can be harnessed to remodel the surrounding matrix. If that matrix is elastic, this feeds back into the droplet’s phase behavior in some unexpected ways. When driven far from equilibrium by localized chemical reactions, droplets display stunning fluid motion, characterized by persistent cell-like motility and directed motion along chemical gradients. Photo credits: Kathryn Rosowski, Andrea Testahttps://cassyni-user-files-prod.s3.amazonaws.com/Sn33gyCSfJnqzgF9ror5JE https://cassyni.com/slides/outline/7FawF1vA4rPgEMh2J1BVNV https://cassyni.com/events/7FawF1vA4rPgEMh2J1BVNV/abstract https://cassyni-user-files-prod.s3.amazonaws.com/PvXixWzz6wwikVhwRFqdCr https://cassyni.com/events/7FawF1vA4rPgEMh2J1BVNV?videoPreview=1 EF-Games, Characterizations and Lindström Theoremsnohttps://cassyni.com/events/7FawF1vA4rPgEMh2J1BVNV?videoPreview=12022-10-26T14:00:00+00:003720.88Logica UniversalisThe Ehrenfeucht–Fraïsse game for a logic usually provides an intuitive characterization of its expressive power while in abstract model theory, logics are compared by their expressive powers. In this presentation , I will expose this connection in details by showing a general Lindström theorem for logics which have certain types of Ehrenfeucht–Fraïsse games. I will first prove a general characterization theorem and then move forward to get a Lindström theorem (with more assumptions about the logics we consider). The results generalize and uniform some known results and may be applied to get new Lindström theorems for logics.https://cassyni-user-files-prod.s3.amazonaws.com/PvXixWzz6wwikVhwRFqdCr https://cassyni.com/slides/outline/pTHjVoPEpJbqVSnh6BhP3 https://cassyni.com/events/pTHjVoPEpJbqVSnh6BhP3/abstract https://cassyni-user-files-prod.s3.amazonaws.com/LyRCPwM2WBHKwJvoYvq49t https://cassyni.com/events/pTHjVoPEpJbqVSnh6BhP3?videoPreview=1 Cause-and-effect of linear mechanisms sustaining in wall turbulencenohttps://cassyni.com/events/pTHjVoPEpJbqVSnh6BhP3?videoPreview=12021-05-21T15:00:00+00:001945.44Journal of Fluid MechanicsDespite the nonlinear nature of turbulence, there is evidence that part of the energy-transfer mechanisms sustaining wall turbulence can be ascribed to linear processes. The different scenarios stem from linear stability theory and comprise exponential instabilities, neutral modes, transient growth from non-normal operators, and parametric instabilities from temporal mean-flow variations, among others. These mechanisms, each potentially capable of leading to the observed turbulence structure, are rooted in simplified physical models. Whether the flow follows any or a combination of them remains elusive. Here, we evaluate the linear mechanisms responsible for the energy transfer from the streamwise-averaged mean-flow U to the fluctuating velocities u’. To that end, we use cause-and-effect analysis based on interventions: manipulation of the causing variable leads to changes in the effect. This is achieved by direct numerical simulation of turbulent channel flows at low Reynolds number, in which the energy transfer from U to u’ is constrained to preclude a targeted linear mechanism. We show that transient growth is sufficient for sustaining realistic wall turbulence. Self-sustaining turbulence persists when exponential instabilities, neutral modes, and parametric instabilities of the mean flow are suppressed. We further show that a key component of transient growth is the Orr/push-over mechanism induced by spanwise variations of the base flow.https://cassyni-user-files-prod.s3.amazonaws.com/LyRCPwM2WBHKwJvoYvq49t https://cassyni.com/slides/outline/EAfPtayWDG9TjAgbfSkRXB https://cassyni.com/events/EAfPtayWDG9TjAgbfSkRXB/abstract https://cassyni-user-files-prod.s3.amazonaws.com/3mzPou1TwKNZzDfmGJ2ZGa https://cassyni.com/events/EAfPtayWDG9TjAgbfSkRXB?videoPreview=1 Random Lasersnohttps://cassyni.com/events/EAfPtayWDG9TjAgbfSkRXB?videoPreview=12022-07-04T08:20:00+00:002966.04ETOPIMOne essential component of a laser is the cavity, which provides optical confinement and feedback for lasing oscillation. In a highly disordered medium, light experiences multiple scattering and undergoes a random walk. Surprisingly, lasing can occur in a random system without well-defined cavities. Such lasers are called random lasers, whose development was dated back to the early years of laser development. Over the past two decades there have been extensive experimental and theoretical studies on random lasers. I will review the random laser development and describe the lasing mechanism. In particular, I will discuss coherent lasing with resonant feedback in strongly scattering semiconductor power and polycrystalline films. The interference of multiply scattered light also provides a novel mechanism of three-dimensional optical confinement in disordered microlasers. Finally, I will describe practical applications that will benefit from the unique characteristics of random lasers. For example, a random laser can provide intense radiation with low spatial coherence, thus combining the high brightness of a laser with the low coherence of a LED. Full-field images taken under random laser illumination are free of speckle noise and coherent crosstalk.https://cassyni-user-files-prod.s3.amazonaws.com/3mzPou1TwKNZzDfmGJ2ZGa https://cassyni.com/slides/outline/GduR81D8QYux67AAD8f4F7 https://cassyni.com/events/GduR81D8QYux67AAD8f4F7/abstract https://cassyni-user-files-prod.s3.amazonaws.com/RumqegirPk73XWyqzR4BY https://cassyni.com/events/GduR81D8QYux67AAD8f4F7?videoPreview=1 Eigenstates of Maxwell's equations in multi-constituent microstructuresnohttps://cassyni.com/events/GduR81D8QYux67AAD8f4F7?videoPreview=12022-07-05T13:10:00+00:002000.04ETOPIMThe eigenstates of Maxwell’s monochromatic equations in a multi-constituent composite medium are developed and used to expand a physical field that is created either by an externally given current density or by an incident external field. The local electric permitttivity κ(r), as well as the local magnetic permmeability μ(r), are assumed to have uniform values in each constituent, but to differ in the different constituents.https://cassyni-user-files-prod.s3.amazonaws.com/RumqegirPk73XWyqzR4BY https://cassyni.com/slides/outline/9EBMRkWFpgcSL4yFey3Ro3 https://cassyni.com/events/9EBMRkWFpgcSL4yFey3Ro3/abstract https://cassyni-user-files-prod.s3.amazonaws.com/SN4iGx37ZSFCUmqYFUhSWS https://cassyni.com/slides/outline/BhRNfAjt1yNvh1SpCex4Wy https://cassyni.com/events/BhRNfAjt1yNvh1SpCex4Wy/abstract https://cassyni-user-files-prod.s3.amazonaws.com/2dBQovbF1Ws2o1Emk2sroG https://cassyni.com/events/BhRNfAjt1yNvh1SpCex4Wy?videoPreview=1 A Localization Landscape Approach to Hopping Transport in Disordered Medianohttps://cassyni.com/events/BhRNfAjt1yNvh1SpCex4Wy?videoPreview=12022-07-08T15:00:00+00:00666.04ETOPIMAt low injection and low temperatures, electron transport in disordered semiconductors is dominated by phonon-assisted hopping between localized states [1]. This hopping transport is often studied using the Miller-Abrahams’ model [2] that requires a set of empirical parameters to define the hopping rates and the preferential paths between the states. Here, we show that this hopping network can actually be visualized through an effective potential derived from the localization landscape theory [3], and that the coupling between localized states is essentially supported along geodesics of a metric [4] deduced from the localization landscape. We compute the hopping rates and mobilities using this effective potential, and compare its predictions with the true eigenstate-based calculations. We numerically calculate how the hopping rates and mobilities vary with the strength and type of disordered potential, and demonstrate the applicability of the localization landscape theory in modeling hopping transport in a wide class of disordered systems.https://cassyni-user-files-prod.s3.amazonaws.com/2dBQovbF1Ws2o1Emk2sroG https://cassyni.com/slides/outline/JcXTRNK7Zk4SLJ8nrfTSJH https://cassyni.com/events/JcXTRNK7Zk4SLJ8nrfTSJH/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Gu4xmJFwt9iX9AF8MF5iAJ https://cassyni.com/events/JcXTRNK7Zk4SLJ8nrfTSJH?videoPreview=1 The physics of road and track cyclingnohttps://cassyni.com/events/JcXTRNK7Zk4SLJ8nrfTSJH?videoPreview=12020-05-01T15:00:00+00:003344.88Journal of Fluid MechanicsEven if the first bicycle was invented in Germany in 1817 by Karl von Drais, the Physics of cycling probably started in 1869 with the work of the Scottish mechanical engineer W.J.M. Rankine entitled On the dynamical principles of the motion of velocipedes. Among the questions which have been addressed in the subject, stability is probably the most debated. First addressed in 1890 by J. Boussinesq (Aperçu sur la théorie de la bicyclette) and F. Klein and A. Sommerfeld (Stabilitat des Fahrrads) research continued with tens of contributions up to 2011 (see Historical Review of Thoughts on Bicycle Self-Stability by Meijaard, Papadopoulos, Ruina and Schwab). The questions discussed during this webinar seminar won't however be connected to stability but related to races: For road cycling we will wonder why three jerseys? Tour de France, Giro d’Italia and the Vuelta in Spain are the three Grand Tours of professional road cycling. Three weeks long with daily stages, these three races all use three jerseys to distinguish the leader, the best sprinter and the best climber. We will first discuss the physics of road cycling and show that these three jerseys are respectively associated with three different dynamical regimes. We will then propose a phase diagram for road cycling which enables the discussion of the different physiological characteristics observed in the peloton. For track cycling we will wonder why Team Great Britain is so strong? Analysing the Individual pursuit of Graham Obree World Title in 1993 will be our starting point. We will then move to the qualifying 200m of Jason Kenny and finish with team pursuit. The main point will be to discuss why and how the fixed gear condition of track cycling changes the law of races.https://cassyni-user-files-prod.s3.amazonaws.com/Gu4xmJFwt9iX9AF8MF5iAJ https://cassyni.com/slides/outline/VUnkSQYfDpEurZxpUCh8F7 https://cassyni.com/events/VUnkSQYfDpEurZxpUCh8F7/abstract https://cassyni-user-files-prod.s3.amazonaws.com/PoheyoR3cV1mViZ2wKV6LW https://cassyni.com/events/VUnkSQYfDpEurZxpUCh8F7?videoPreview=1 Free-flight experiments in high-speed wind tunnelsnohttps://cassyni.com/events/VUnkSQYfDpEurZxpUCh8F7?videoPreview=12023-02-07T15:00:00+00:003155.64Experiments in FluidsFree-flight experiments are an invaluable tool in hypersonic wind tunnels for studying a range of unsteady high-speed-flow problems: relevant examples include store, stage, and shroud separation, destructive re-entry and meteoroid fragmentation. Also, since traditional force-balance methods are difficult or impossible to implement in short-duration hypersonic tunnels, free-flight techniques can provide a convenient means of aerodynamic measurement in such facilities, provided the model motion can be accurately recorded. In the first part of this seminar, I will describe the development of a class of optical-tracking techniques for the nonintrusive measurements of model orientation and position in free-flight experiments. The common thread of these tracking techniques is the combination of subpixel edge detection applied to experimental images (typically shadowgraph or schlieren) with least-squares fitting of a generated model outline. The most sophisticated of these techniques has been shown to be capable of 5 DoF measurements of arbitrary geometries (with a single camera), with a precision approaching 1 micron and 0.001 degrees. In the second part of the seminar, I will describe the application of free-flight and optical-tracking techniques to several high-speed problems of interest, including the determination of force and moment coefficients on complex bodies, separation of objects from a ramp surface, and aerodynamic breakup of particle clusters. https://cassyni-user-files-prod.s3.amazonaws.com/PoheyoR3cV1mViZ2wKV6LW https://cassyni.com/slides/outline/S2FX7d1z9cNGpsfFpYKAiH https://cassyni.com/events/S2FX7d1z9cNGpsfFpYKAiH/abstract https://cassyni-user-files-prod.s3.amazonaws.com/4WH7zNWByrTYFeBWSGoG3G https://cassyni.com/events/S2FX7d1z9cNGpsfFpYKAiH?videoPreview=1 Changes in survival over time for primary brain and other CNS tumors in the United States, 2004–2017nohttps://cassyni.com/events/S2FX7d1z9cNGpsfFpYKAiH?videoPreview=12022-12-05T21:00:00+00:001713.04Journal of Neuro-OncologyHosts Dr. Randy D'amico and Dr. Jason Sheehan from the Journal of Neuro-Oncology sit down with Gino Cioffi of the National Cancer Institute and Carol Kruchkoo of the Central Brain Tumor Registry of the United States to discuss their article on the changes in survival over time for primary brain and other CNS tumors in the United States from 2004–2017.https://cassyni-user-files-prod.s3.amazonaws.com/4WH7zNWByrTYFeBWSGoG3G https://cassyni.com/slides/outline/UVVYM3FcLu8mBp8pNEDoSD https://cassyni.com/events/UVVYM3FcLu8mBp8pNEDoSD/abstract https://cassyni-user-files-prod.s3.amazonaws.com/ShY2XEBi5HW6YXYasbS9Li https://cassyni.com/events/UVVYM3FcLu8mBp8pNEDoSD?videoPreview=1 Optimization, Speed-up, and Out-of-distribution Prediction in Deep Learningnohttps://cassyni.com/events/UVVYM3FcLu8mBp8pNEDoSD?videoPreview=12022-04-20T09:00:00+00:003079.8DataSıgIn this talk, I will introduce our investigations on how to make deep learning easier to optimize, faster to train, and more robust to out-of-distribution prediction. To be specific, we design a group-invariant optimization framework for ReLU neural networks; we compensate the gradient delay in asynchronized distributed training; and we improve the out-of-distribution prediction by incorporating “causal” invariance.https://cassyni-user-files-prod.s3.amazonaws.com/ShY2XEBi5HW6YXYasbS9Li https://cassyni.com/slides/outline/4Hiw5YYtqTzs28NySSvW1s https://cassyni.com/events/4Hiw5YYtqTzs28NySSvW1s/abstract https://cassyni-user-files-prod.s3.amazonaws.com/CaWtGikATvGz6JCTLFSZsc https://cassyni.com/events/4Hiw5YYtqTzs28NySSvW1s?videoPreview=1 Actor-Critic Method for Solving High Dimensional Hamilton-Jacobi-Bellman type PDEsnohttps://cassyni.com/events/4Hiw5YYtqTzs28NySSvW1s?videoPreview=12023-04-03T14:00:00+00:003528.8Journal of Computational PhysicsIn this talk, we will discuss numerical approach to solve high dimensional Hamilton-Jacobi-Bellman (HJB) type elliptic partial differential equations (PDEs). The HJB PDEs, reformulated as optimal control problems, are tackled by the actor-critic framework inspired by reinforcement learning, based on neural network parametrization of the value and control functions. Within the actor-critic framework, we employ a policy gradient approach to improve the control, while for the value function, we derive a variance reduced least-squares temporal difference method using stochastic calculus. We will also discuss convergence analysis for the actor-critic method, in particular the policy gradient method for solving stochastic optimal control. Joint work with Jiequn Han (Flatiron Institute) and Mo Zhou (Duke University).https://cassyni-user-files-prod.s3.amazonaws.com/CaWtGikATvGz6JCTLFSZsc https://cassyni.com/events/EfLd3u8v45dHYdg7TYsPhP/abstract https://cassyni-user-files-prod.s3.amazonaws.com/MWjBY3thTyghaPr8CdtnNr https://cassyni.com/events/9irab4fffW6G9XxmT5APyF/seminar/qa https://cassyni.com/slides/outline/9irab4fffW6G9XxmT5APyF https://cassyni.com/events/9irab4fffW6G9XxmT5APyF/abstract https://cassyni-user-files-prod.s3.amazonaws.com/5AnpaU3Ht3y6vVumTGh7BL https://cassyni.com/events/9irab4fffW6G9XxmT5APyF?videoPreview=1 Structure Preserving Numerical Methods for Magnetic Fusionnohttps://cassyni.com/events/9irab4fffW6G9XxmT5APyF?videoPreview=12023-10-16T14:00:00+00:003716.52Journal of Computational PhysicsMany plasma physics models have been proved to possess a non-canonical hamiltonian structure. Invariants like the hamiltonian or Casimir invariants like div B = 0 follow immediately from this structure. Hence discretizing the infinite dimensional hamiltonian structure so that we obtain a finite dimensional hamiltonian structure provides a natural way to conserve discrete invariants. After a short review of geometric discretization for kinetic and hybrid fluid-kinetic models, we will focus on structure preserving discretization of compressible ideal MHD. In order to robustly handle shocks and also keep the symmetries inherent to the MHD model, we will introduce a semi-implicit hybrid model coupling Finite Element Exterior Calculus and Finite Volume schemes. A splitting approach is designed so that we may take advantage of the conservation properties and robustness of the Finite Volume schemes for the non-linear advection, while relying on a structure-preserving discretization of the magneto-acoustic terms based on Finite Element Exterior calculus. Moreover, the nonlinear convective terms are treated via an explicit time-discretization, while the magnetic and acoustic terms are solved via an implicit time-discretization. Thanks to this, the resulting CFL condition will depend, at least formally, only on the fluid velocity and not on the Alfvén or sound speeds that may become too stringent in the low Mach regimes. In this approach, the divergence free constraint of the magnetic field is always preserved up to machine precision, and the symmetry of the physical model is also reflected to the symmetry of the final algebraic nonlinear systems that are solved in an implicit step. Thanks to the symmetry of the systems, the very efficient matrix-free conjugate gradient method may be employed.https://cassyni-user-files-prod.s3.amazonaws.com/5AnpaU3Ht3y6vVumTGh7BL https://cassyni.com/events/4JT83uwwJr5kpYVQsDKzS1/seminar/qa https://cassyni.com/slides/outline/4JT83uwwJr5kpYVQsDKzS1 https://cassyni.com/events/4JT83uwwJr5kpYVQsDKzS1/abstract https://cassyni-user-files-prod.s3.amazonaws.com/TQFB8J6jCXBa9MQxz3xYCn https://cassyni.com/events/4JT83uwwJr5kpYVQsDKzS1?videoPreview=1 Isogeometric Analysis: Some recent advances with applications to complex and coupled problemsnohttps://cassyni.com/events/4JT83uwwJr5kpYVQsDKzS1?videoPreview=12025-01-16T13:00:00+00:002906.04MOX Laboratory - Department of MathematicsIsogeometric Analysis (IGA) is a successful simulation framework originally proposed by T.J.R. Hughes et al. in 2005, with the aim of bridging Computational Mechanics and Computer Aided Design. In addition to this, thanks to the high-regularity properties of its basis functions, IGA has shown a better accuracy per degree-of-freedom and an enhanced robustness with respect to standard finite elements in many applications, ranging from solids and structures to fluids, as well as to different kinds of coupled problems, also opening the door to the approximation in primal form of higher-order partial differential equations. After a concise introduction of the basic isogeometric concepts, this lecture aims at presenting an overview of some recent advances with a special focus on coupled problems where the characteristics of IGA seem to be of great advantage, including the simulation of fluid-structure interaction in different contexts (e.g., biomedical problems), studies on the effects of mechanically-induced stresses on prostate cancer growth, thermo-mechanical simulations for additive manufacturing processes, electro-mechanical simulations for biological tissues, and the use of phase-field modeling for fracture and topology optimization problems or for predicting the polarization evolution in elastic ferroelectric materials.https://cassyni-user-files-prod.s3.amazonaws.com/TQFB8J6jCXBa9MQxz3xYCn https://cassyni.com/events/XxnakphDHr24qvbHcASkXF/seminar/qa https://cassyni.com/slides/outline/XxnakphDHr24qvbHcASkXF https://cassyni.com/events/XxnakphDHr24qvbHcASkXF/abstract https://cassyni-user-files-prod.s3.amazonaws.com/VdaEse29pWttNKdXnKAB1G https://cassyni.com/events/XxnakphDHr24qvbHcASkXF?videoPreview=1 Quality assurance of reusable plastic packagingnohttps://cassyni.com/events/XxnakphDHr24qvbHcASkXF?videoPreview=12025-03-19T14:30:00+00:001725.04Cambridge PrismsSingle use plastic packaging is widely accepted to cause significant negative environmental impacts. One option to reduce these impacts is to develop commercially viable and socially acceptable reuse systems. Such closed loop packaging systems require careful consideration of reverse (or circular) logistics, financial modelling, and quality control (fulfilling legal requirements and ethical obligations). One of the most prominent barriers to the concept of reusable packaging for food is safety, dictated by challenges of effective cleaning and pack integrity assessment. This talk will explore the potential of a new, real-time, non-contact technique that routinely allows assessment of the cleanliness and integrity of packaging surface surfaces following cleaning. Ultraviolet induced fluorescence of fluorophores within foodstuffs (e.g. within proteins) and polymers enables the rapid detection of residual fouling and pack degradation. The talk will highlight the future challenges of reliable high speed quality assurance as well as other economic and logistical challenges facing the reusable packaging industry.https://cassyni-user-files-prod.s3.amazonaws.com/VdaEse29pWttNKdXnKAB1G https://cassyni.com/events/9jamZS4i8tB9wx5CsqZtPP/abstract https://cassyni-user-files-prod.s3.amazonaws.com/6koENfhEcqz5HfkUmZ4VBt https://cassyni.com/events/2KtKyosixNo6HNbD5U9f7T/seminar/qa https://cassyni.com/slides/outline/2KtKyosixNo6HNbD5U9f7T https://cassyni.com/events/2KtKyosixNo6HNbD5U9f7T/abstract https://cassyni-user-files-prod.s3.amazonaws.com/HD8bK1wG3iXHySok46rj1Y https://cassyni.com/events/2KtKyosixNo6HNbD5U9f7T?videoPreview=1 Access to Material Basic Needs and Women's Healthnohttps://cassyni.com/events/2KtKyosixNo6HNbD5U9f7T?videoPreview=12025-01-15T15:00:00+00:003269.92Women's HealthMaterial basic needs such as menstrual supplies, infant and child diapers, and adult incontinence products are required for health and hygiene, yet are often overlooked for their role in facilitating healthy behaviours, community participation, mental health, and overall well-being. Unmet material basic needs are associated with multiple and compounding stressors - the stress of not having these needs met, and the stress of trying to meet them. These stressors influence health. Although screening in the healthcare setting for social drivers of health has increased in recent years, few of the screening tools used assess unmet needs for the most basic material essentials like toothpaste, laundry detergent, and hygiene products. The aim of this Special Collection is to document the link between access to material basic needs and women’s health across the life course.https://cassyni-user-files-prod.s3.amazonaws.com/HD8bK1wG3iXHySok46rj1Y https://cassyni.com/slides/outline/QZ4X4ZzLhyiEMM4peHb27F https://cassyni.com/events/QZ4X4ZzLhyiEMM4peHb27F/abstract https://cassyni-user-files-prod.s3.amazonaws.com/YZ1W6HZzwkR2nWDjTkpX8A https://cassyni.com/events/T2JYHzDxuGV3Spswbgjko7/seminar/qa https://cassyni.com/slides/outline/T2JYHzDxuGV3Spswbgjko7 https://cassyni.com/events/T2JYHzDxuGV3Spswbgjko7/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Q8YSvGXbGmSM8rjen4oD1p https://cassyni.com/events/T2JYHzDxuGV3Spswbgjko7?videoPreview=1 The RI Life Index: Perceptions about the Social Needs of Rhode Island Residentsnohttps://cassyni.com/events/T2JYHzDxuGV3Spswbgjko7?videoPreview=12025-04-03T20:00:00+00:003648.12Family MedicineObjectives: * Describe results of the unique RI Life Index Study * Illustrate the use of collaborations with community-based organizations to assess social needs of Rhode Island residents * Discuss implications and impacts of results from the RI Life Index on patients and primary care practiceshttps://cassyni-user-files-prod.s3.amazonaws.com/Q8YSvGXbGmSM8rjen4oD1p https://cassyni.com/slides/outline/CCrQuUpDjXsR8tbEb2v2FP https://cassyni.com/events/CCrQuUpDjXsR8tbEb2v2FP/abstract https://cassyni-user-files-prod.s3.amazonaws.com/AWGhjTWee9wKgw26KRcr4N https://cassyni.com/events/CCrQuUpDjXsR8tbEb2v2FP?videoPreview=1 Human heart under stress: its mysteries revealed by mechano-imaging modelingnohttps://cassyni.com/events/CCrQuUpDjXsR8tbEb2v2FP?videoPreview=12024-12-03T03:00:00+00:003655.04The Auckland Bioengineering InstituteBiological tissues remodeling is largely due to mechanical stresses withstood by the cells, with both anabolic and catabolic responses depending on loading type, magnitude, and duration. Thus in the last 16 years, my research program aimed at providing new imaging and modeling technologies for the robust in vivo mechanical stress evaluation within musculoskeletal or cardiac tissues, a cornerstone in understanding the fundamental mechanobiological processes in humans. It is well established that physical activity is beneficial for human health. Indeed, if more stress is withstood by the cells, more remodeling occurs. However, the thresholds beyond which exercise loading causes regenerative or degenerative remodeling still have to be defined. This issue confirmed my willingness to direct my research towards understanding and quantifying the cardiac behavior under stress conditions through new mechano-imaging modeling technologies. This presentation will introduce the mechanical characterization of human tissues, with an application to the differential impact of chemotherapy on cardiac wall structure. The limits of mechanical testing on biological tissues will be discussed to introduce multiparametric MRI, with an application as an indirect evaluation tool of the mechanical properties of ex-vivo cardiac tissues. Finite element models of the heart will then be summarized, followed by their use for the prediction of the mechanical properties of the myocardium from CMR in acute Lymphoblastic Leukemia survivors and for MRI-based analysis of the blood flow in the left ventricle. The limits of rest data on patients will be discussed to introduce a study on cardiac mechanical performance in childhood ALL survivors assessed by combined CMR and incremental exercise test. The development of a novel inotropic Exercise CMR Protocol for Cardiac Mechanics Characterization will conclude this presentation.https://cassyni-user-files-prod.s3.amazonaws.com/AWGhjTWee9wKgw26KRcr4N https://cassyni.com/events/NaVizTv8MWRZosamthoMZX/seminar/qa https://cassyni.com/slides/outline/NaVizTv8MWRZosamthoMZX https://cassyni.com/events/NaVizTv8MWRZosamthoMZX/abstract https://cassyni-user-files-prod.s3.amazonaws.com/U7HdBCjfiHbP8R4NhbX5iv https://cassyni.com/events/NaVizTv8MWRZosamthoMZX?videoPreview=1 Reflections and Insight on Response to a Public Health Crisis: The Addictions Grand Challenge (AGC)nohttps://cassyni.com/events/NaVizTv8MWRZosamthoMZX?videoPreview=12025-01-15T18:30:00+00:003389.76Sage PublishingThe use of heroin, prescription painkillers, methamphetamines, and fentanyl led to a national health crisis in 2017, resulting in 1,852 overdose deaths in Indiana. Governor Eric J. Holcomb made tackling substance use in the state one of his highest priorities, calling on all Hoosiers to collaborate. In October 2017, Indiana University (IU) President Michael A. McRobbie responded, announcing that the University would be initiating the 'Responding to the Addictions Crisis Grand Challenge' (AGC). Partners included Governor Holcomb, IU Health, and Eskenazi Health. Leveraging the university's research strengths and partnering with more than 160 community organizations across the state, the AGC sought to address substance use facing Indiana and beyond. Fifty interdisciplinary research projects were created through the AGC, focusing on IU’s greatest strength in five areas: education, training, and certification; (2) data science and analysis; (3) policy analysis, economics, and law; (4) basic, applied, and translational research; (5) community engagement and workforce development; and (6) diversity, equity, and inclusion. This seminar and associated supplement describes the IU approach to address the health of the people of the State, investigator-initiated projects and research conducted to inform practice, strategy and policy.https://cassyni-user-files-prod.s3.amazonaws.com/U7HdBCjfiHbP8R4NhbX5iv https://cassyni.com/events/R3jkDt9kYoCNuMPtr6x6FP/seminar/qa https://cassyni.com/slides/outline/R3jkDt9kYoCNuMPtr6x6FP https://cassyni.com/events/R3jkDt9kYoCNuMPtr6x6FP/abstract https://cassyni-user-files-prod.s3.amazonaws.com/GQmBgFA6Ta3wBy35gNVovN https://cassyni.com/events/R3jkDt9kYoCNuMPtr6x6FP?videoPreview=1 Lattice Boltzmann for solid mechanics: elastostatics and elastodynamicsnohttps://cassyni.com/events/R3jkDt9kYoCNuMPtr6x6FP?videoPreview=12025-03-06T13:00:00+00:003036.04MOX Laboratory - Department of MathematicsThe talk overviews recent research by the authors on the development of second-order consistent and stable lattice Boltzmann formulations to solve elastostatics and elastodynamics problems. The first proposed scheme [1] solves the quasi-static equations of linear elasticity in two dimensions using a collision operator with multiple relaxation times. In contrast to previous works, our formulation solves for a single distribution function with a standard velocity set and avoids any recourse to finite difference approximations. As a result, all computational benefits of the lattice Boltzmann method can be used to full capacity. The second proposed scheme [2] solves the equations of linear elastodynamics in two dimensions (the extension to three dimensions is currently also available but still unpublished). The construction of the numerical scheme uses an equivalent first-order hyperbolic system of equations as an intermediate step, for which a vectorial lattice Boltzmann formulation is introduced. The only difference to conventional lattice Boltzmann formulations is the usage of vector-valued populations, so that once again all computational benefits of the algorithm are preserved. Both schemes are systematically derived using the asymptotic expansion technique. Stability is assessed for elastostatics with von Neumann analysis, whereas in elastodynamics we exploit the notion of pre-stability structures to prove stability for an arbitrary combination of material parameters under a CFL-like condition. Boundary formulation for various cases are proposed [3]. All theoretical derivations are numerically verified by convergence studies using manufactured solutions and long-term stability tests. [1] O. Boolakee, M. Geier, L. De Lorenzis (2023), A new Lattice Boltzmann scheme for linear elastic solids: periodic problems. Computer Methods in Applied Mechanics and Engineering, 404: 115756. [2] O. Boolakee, M. Geier, L. De Lorenzis (2025). Lattice Boltzmann for linear elastodynamics: periodic problems and Dirichlet boundary conditions. Computer Methods in Applied Mechanics and Engineering, 433: 117469. [3] O. Boolakee, M. Geier, L. De Lorenzis (2023), Dirichlet and Neumann boundary conditions for a lattice Boltzmann scheme for linear elastic solids on arbitrary domains. Computer Methods in Applied Mechanics and Engineering, 415: 116225.https://cassyni-user-files-prod.s3.amazonaws.com/GQmBgFA6Ta3wBy35gNVovN https://cassyni.com/events/He1gXdSsxvtYQmsRtE6MqP/seminar/qa https://cassyni.com/slides/outline/He1gXdSsxvtYQmsRtE6MqP https://cassyni.com/events/He1gXdSsxvtYQmsRtE6MqP/abstract https://cassyni-user-files-prod.s3.amazonaws.com/TNft6QxDMZ6BG2RZWN84S2 https://cassyni.com/events/He1gXdSsxvtYQmsRtE6MqP?videoPreview=1 Cryogenic Hydrogen Electric Powertrains – A Pathway to Zero Emission Flightnohttps://cassyni.com/events/He1gXdSsxvtYQmsRtE6MqP?videoPreview=12025-01-22T14:00:00+00:003619.24Brahmal Vasudevan Institute for Sustainable AviationGKN Aerospace is committed to the achievement of sustainable aviation at the earliest practical opportunity and continues focused research and development in order to meet this goal. As part of this, one of the technologies being considered is a novel cryogenic Hydrogen Electric Propulsion (H2EP) configuration, which has been under detailed study for a number of years, and is now in the technology demonstration phase. This presentation will describe the progress in system architecture development and demonstration achieved to date via the ATI funded H2GEAR, HyFive and H2FlyGHT research programmes. The presentation will also detail the commercial aerospace market context of the work to date, and the potential impact that achievement of the technology could make as a pathway towards zero emission (at the point of use) flight. https://cassyni-user-files-prod.s3.amazonaws.com/TNft6QxDMZ6BG2RZWN84S2 https://cassyni.com/slides/outline/VzDngiczwNjQJT7Eraf5yX https://cassyni.com/events/VzDngiczwNjQJT7Eraf5yX/abstract https://cassyni-user-files-prod.s3.amazonaws.com/TJTyAqH8c2ytAGnWV4aFTk https://cassyni.com/events/VzDngiczwNjQJT7Eraf5yX?videoPreview=1 Molecular and genetic basis of cold tolerance in maizenohttps://cassyni.com/events/VzDngiczwNjQJT7Eraf5yX?videoPreview=12024-10-24T13:00:00+00:001686.72The New Phytologist FoundationCold stress is a major abiotic stress that threatens maize (Zea mays L.) production worldwide. Using reverse genetics approach, we identified type-A Response Regulator 1 (ZmRR1) as a positive regulator, and transcription factor ZmbZIP68 and tonoplast intrinsic protein TIP4;3 as negative regulators of maize tolerance, respectively. Th protein stability of ZmRR1 and ZmbZIP68 is controlled by ZmMPK8-mediated phosphorylation. The natural variations of ZmRR1 occur at its phosphorylation site, resulting in the divergence of protein stability and chilling tolerance. The ZmbZIP68 locus was a target of selection during early domestication. An Indel polymorphism in the ZmbZIP68 promoter resulted in the differential expression of ZmbZIP68 between maize and its wild ancestor teosinte. TIPs are a subfamily of aquaporins in plants. Here, we report that TIP family proteins are involved in maize cold tolerance. The expression of most TIP genes was responsive to cold treatment. Overexpressing TIP2;1, TIP3;2 or TIP4;3 markedly diminished the cold tolerance of maize seedlings, whereas loss-of-function mutants of TIP4;3 showed enhanced cold tolerance. Candidate gene-based association analysis indicated that a 328-bp transposon insertion in the TIP4;3 promoter was strongly associated with maize cold tolerance. The detailed regulatory mechanism will be presented.https://cassyni-user-files-prod.s3.amazonaws.com/TJTyAqH8c2ytAGnWV4aFTk https://cassyni.com/slides/outline/8FhCee9udEMzVhpxUVGRH7 https://cassyni.com/events/8FhCee9udEMzVhpxUVGRH7/abstract https://cassyni-user-files-prod.s3.amazonaws.com/TKY2g6GUccRApv4qo17GQW https://cassyni.com/events/8FhCee9udEMzVhpxUVGRH7?videoPreview=1 Design of composite materials and structures across the scales: physical and data-driven modelsnohttps://cassyni.com/events/8FhCee9udEMzVhpxUVGRH7?videoPreview=12024-12-13T10:00:00+00:003661.32Department of Aeronautics and AstronauticsThe ambitious goal of reaching net-zero emissions in aviation by 2050 can only be met by science-based disruptive innovations, including those that have the potential to reduce aircraft structural weight. Based on the hypothesis that composite materials and structures are currently not used to their full potential, a vision of a systems approach for the inverse design of composite materials and structures across different spatial scales will be presented. The main building blocks of the proposed approach, linking the macrostructure of a composite structure to the microstructure of a composite material, will be discussed. At the micromechanical level, these include the generation of representative volume elements, appropriate material models for the constituents, reduced order models and associated surrogates. A recently developed mesomechanical modelling approach that simulates the propagation of the different failure mechanisms observed in composite laminates under finite strains using a new homogenization-based smeared crack formulation will be discussed. At the structural level, building on data generated analytically and on reduced representations of composite lay-ups, four machine learning algorithms are used to predict the strength of composite laminates with notches of several geometries and the corresponding statistical distribution, associated to material and geometrical variability. It will be shown that the proposed approach may lead to significant reductions of the time required to virtually certify composite aircraft structures.https://cassyni-user-files-prod.s3.amazonaws.com/TKY2g6GUccRApv4qo17GQW https://cassyni.com/events/2pZZ9838oCGv6qaisaGdHf/seminar/qa https://cassyni.com/slides/outline/2pZZ9838oCGv6qaisaGdHf https://cassyni.com/events/2pZZ9838oCGv6qaisaGdHf/abstract https://cassyni-user-files-prod.s3.amazonaws.com/YPyLEMNJgRFGSXAyNVGq66 https://cassyni.com/events/2pZZ9838oCGv6qaisaGdHf?videoPreview=1 Protective metamaterialsnohttps://cassyni.com/events/2pZZ9838oCGv6qaisaGdHf?videoPreview=12025-03-11T14:00:00+00:003069.04MetaMATReducing the prevalence and consequence of injuries by improving protective and biomedical equipment is a core concept of preventative medicine, reducing hospital visits and keeping people active. Mechanical metamaterials, rationally designed structures with combinations of mechanical properties that can’t usually be achieved in their unstructured constituent materials, are being tailored to replace conventional materials used in protective and biomedical equipment. These metamaterials can be adapted to various impact conditions, body types, and user requirements (e.g., performance and comfort). The talk will focus on the challenge of designing and producing such adaptive or tailored systems. The unusual properties and physical risks that will be discussed include i) Negative stiffness/buckling to protect against distributed loads. ii) Negative Poisson’s ratio and force-torque coupling, to adapt between distributed and concentrated loads. iii) Response switching to adapt to impact severity.https://cassyni-user-files-prod.s3.amazonaws.com/YPyLEMNJgRFGSXAyNVGq66 https://cassyni.com/events/3KDABogfEepy6c7cU1ZRYy/seminar/qa https://cassyni.com/slides/outline/3KDABogfEepy6c7cU1ZRYy https://cassyni.com/events/3KDABogfEepy6c7cU1ZRYy/abstract https://cassyni-user-files-prod.s3.amazonaws.com/UEfcZQ5mz9QJUM8Wb6rCPY https://cassyni.com/events/3KDABogfEepy6c7cU1ZRYy?videoPreview=1 Line of Sight Stabilization for Directed Energy Systemsnohttps://cassyni.com/events/3KDABogfEepy6c7cU1ZRYy?videoPreview=12025-01-23T20:00:00+00:003554.04AIAA Journal**Bryan Kelchner**, VP of Engineering at Teknicare, Inc., a company that specializes in directed-energy (DE) systems engineering, design, development, integration, and testing of beam control and laser systems for DoD; **Victor Beazel**, Senior Dynamics and Controls Engineer at Teknicare; and **Steven Griffin**, Boeing Senior Technical Fellow will talk about challenges of airborne and space-based high-energy laser systems’ line-of-sight control. This authors seminar addresses DE precision-pointing requirements and their associated implementation alternatives in the context of strapdown and stable platform inertial reference technologies. This seminar is based on the article linked above as the Featured Publication, published in the AIAA Journal. For those who are interested in DE, please also visit our [virtual collection on “Directed Energy for Aerospace Applications”](https://arc.aiaa.org/toc/aiaaj/Virtual+Collection/4).https://cassyni-user-files-prod.s3.amazonaws.com/UEfcZQ5mz9QJUM8Wb6rCPY https://cassyni.com/slides/outline/AEHcqNk1P4akbR7BqT8Mhf https://cassyni.com/events/AEHcqNk1P4akbR7BqT8Mhf/abstract https://cassyni-user-files-prod.s3.amazonaws.com/FjuLP4KJbKNb5fBZs9uoZ8 https://cassyni.com/events/AEHcqNk1P4akbR7BqT8Mhf?videoPreview=1 Engaging Experiments Made Easynohttps://cassyni.com/events/AEHcqNk1P4akbR7BqT8Mhf?videoPreview=12022-06-16T03:00:00+00:005383.04UKRNJoin Jo Evershed and Nick Hodges as they take you through a range of quick and easy techniques to make your online studies more engaging and get better quality data as a result. We'll show you: • Better approaches to handling issues like attention and comprehension • Techniques for integrating data quality checks into your study design • How to get feedback from your participants that you can actually act on Finally, we’ll mix it up with an introductory guide to turning otherwise dull cognitive tasks into simple games that your participants will enjoy playing. If you want more motivated, more attentive participants for your studies, come along and we’ll share everything we’ve learned from all the top researchers who use Gorilla.https://cassyni-user-files-prod.s3.amazonaws.com/FjuLP4KJbKNb5fBZs9uoZ8 https://cassyni.com/events/6H8QaY5hGm5KxELuiuUkjP/seminar/qa https://cassyni.com/slides/outline/6H8QaY5hGm5KxELuiuUkjP https://cassyni.com/events/6H8QaY5hGm5KxELuiuUkjP/abstract https://cassyni-user-files-prod.s3.amazonaws.com/S6KEhhJcCUAvnsqGcdv6bG https://cassyni.com/events/6H8QaY5hGm5KxELuiuUkjP?videoPreview=1 A Logical Consequence Informed by Probabilitynohttps://cassyni.com/events/6H8QaY5hGm5KxELuiuUkjP?videoPreview=12025-02-26T15:00:00+00:004713.12Logica UniversalisThere are two general conceptions on the relationship between probability and logic. In the first, these systems are viewed as complementary—having offsetting strengths and weaknesses—and there exists a fusion of the two that creates a reasoning system that improves upon each. In the second, probability is viewed as an instance of logic, given some sufficiently broad formulation of it, and it is this that should inform the development of more general reasoning systems. These two conceptions are in conflict with each other, where the root issue of contention is the proper abstraction of the concept of logical consequence. In this work, we put forth a proposal on this abstraction based on an extension of the subset relation through the use of projections, which in turn, allows for the formalization of valid inferences to more general settings. Our proposal results in a formalism that encompasses probability and classical logic, and importantly, does so with minimal machinery. This formalism makes assertions about the relationship between these two systems that are explicit, and suggests a path forward in the development of alternatives to them.https://cassyni-user-files-prod.s3.amazonaws.com/S6KEhhJcCUAvnsqGcdv6bG https://cassyni.com/slides/outline/L7HKsgCPZaaobQocdaqAUD https://cassyni.com/events/L7HKsgCPZaaobQocdaqAUD/abstract https://cassyni-user-files-prod.s3.amazonaws.com/HqSAYbyPb9p7PCbKRwj6GN https://cassyni.com/events/L7HKsgCPZaaobQocdaqAUD?videoPreview=1 Adapting crops for climate change: regaining lost abiotic stress tolerance in cropsnohttps://cassyni.com/events/L7HKsgCPZaaobQocdaqAUD?videoPreview=12025-02-13T11:00:00+00:005120.24Frontiers in Science### Ensuring food security in the face of climate change Explore precision breeding strategies for optimizing stress tolerance in crops—reducing their vulnerability to climate extremes and boosting food security. This event builds on a [*Frontiers in Science* lead article](https://www.frontiersin.org/journals/science/articles/10.3389/fsci.2024.1416023/full) outlining these two strategies: genetically altering high-yield plants to cope better with new conditions, or domesticating wild plants with higher stress tolerance to improve their yields. You’ll hear from the article authors and other experts on next steps for success—including cell-based phenotyping to better understand stress tolerance mechanisms and public acceptance of gene editing and new crops. [Register here](https://events.frontiersin.org/adapting-crops-climate-change/C)https://cassyni-user-files-prod.s3.amazonaws.com/HqSAYbyPb9p7PCbKRwj6GN https://cassyni.com/events/8kNRoxKKU3qpKApUGbPPTK/seminar/qa https://cassyni.com/slides/outline/8kNRoxKKU3qpKApUGbPPTK https://cassyni.com/events/8kNRoxKKU3qpKApUGbPPTK/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Uc9pLupRKEpNj66qyFjbJE https://cassyni.com/events/8kNRoxKKU3qpKApUGbPPTK?videoPreview=1 Data-driven Turbulence Modeling: Progress, Pitfalls & Guiding Principlesnohttps://cassyni.com/events/8kNRoxKKU3qpKApUGbPPTK?videoPreview=12025-09-25T14:30:00+00:003646.48AIAA JournalWe have modeled turbulence for a century, and this entire journey has been guided by data and empiricism. Today we have more access to information, and at scale. The peculiar nature and demands of the turbulence modeling challenge, however, mean that one cannot completely bypass mechanistic modeling; data-driven elements must be cast as *consistent and constrained augmentations* of established RANS/LES frameworks. A brief survey will be provided on the progress over the past decade in embedding learned model augmentations. Particular emphasis will be paid to the balance between parsimony and constraint: Use of small set of physically-inspired, locally non-dimensional, bounded features that promote a near one-to-one map from features to an identifiable augmentation, and keeping training and prediction environments consistent by learning to work with operational variables. Pitfalls are subtle, not dramatic—apparent success on curated benchmarks masks brittleness at the point of use. Candid challenges remain: predictive capabilities across geometries and flow regimes, encapsulating nonlocality, identifiability from finite data, and numerical robustness. The thesis is that generality must be earned—by constraining what the particular modeling scenario (rather than purely physical considerations) demands, limiting capacity to what the data can identify, and aligning training with how we actually compute, and what we seek to predict—so data-driven closures become dependable, auditable components of mission-critical CFD. Success in this endeavor also demands principled design of experiments for information-efficient and active data acquisition, and rigorous uncertainty quantification to certify predictions and define operating envelopes.https://cassyni-user-files-prod.s3.amazonaws.com/Uc9pLupRKEpNj66qyFjbJE https://cassyni.com/events/WUu1r2nQnCDE7v6kegn49j/abstract https://cassyni-user-files-prod.s3.amazonaws.com/SGqQczpGovSCsLifw1WncN https://cassyni.com/slides/outline/RYQyPCKAPcgCipPQeD54Rb https://cassyni.com/events/RYQyPCKAPcgCipPQeD54Rb/abstract https://cassyni-user-files-prod.s3.amazonaws.com/MMLq8QnJ1DsTeXNjVBmZU2 https://cassyni.com/events/RYQyPCKAPcgCipPQeD54Rb?videoPreview=1 URBAN OASES: botanic gardens in the 21st centurynohttps://cassyni.com/events/RYQyPCKAPcgCipPQeD54Rb?videoPreview=12024-08-13T12:00:00+00:001552.68The New Phytologist FoundationPlants hold solutions to the global challenges we face. Botanic gardens unite science, conservation, and education, at a time when it has never been more important to engage people with the importance of plants to people and planet. This talk will explore the role of botanic gardens in the 21st century with a focus on the work of the University of Oxford Botanic Garden and Arboretum which spans biomimetics (applications of plant adaptations in technology), conserving under-represented plant groups, and engaging local communities with natural capital. Green spaces are fundamental to the brain health and wellbeing of a growing population. Botanic gardens, rooted historically in plant-based medicine, have a future role in human healing – and a vital one.https://cassyni-user-files-prod.s3.amazonaws.com/MMLq8QnJ1DsTeXNjVBmZU2 https://cassyni.com/slides/outline/LeN7hcStBYJZ8dZiRmm1F https://cassyni.com/events/LeN7hcStBYJZ8dZiRmm1F/abstract https://cassyni-user-files-prod.s3.amazonaws.com/2u6pqHUoTpMsviUe7gener https://cassyni.com/events/LeN7hcStBYJZ8dZiRmm1F?videoPreview=1 Prediction of Flutter Boundary of a Full Aircraft using a CFD-Based Reduced Order Methodnohttps://cassyni.com/events/LeN7hcStBYJZ8dZiRmm1F?videoPreview=12024-12-06T17:00:00+00:002072.92JKW Symposium TeamNo abstracthttps://cassyni-user-files-prod.s3.amazonaws.com/2u6pqHUoTpMsviUe7gener https://cassyni.com/events/3otPM7r55UJnv578G7gPjB/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Dg3qEfyNXm2ZK42datkZzn https://cassyni.com/events/MbFm8MerHKAn5dd8XfRTTK/seminar/qa https://cassyni.com/slides/outline/MbFm8MerHKAn5dd8XfRTTK https://cassyni.com/events/MbFm8MerHKAn5dd8XfRTTK/abstract https://cassyni-user-files-prod.s3.amazonaws.com/SHhfDw2K8KBgGYn2D95Tok https://cassyni.com/events/MbFm8MerHKAn5dd8XfRTTK?videoPreview=1 Institution-independent Model Theory, 2nd editionnohttps://cassyni.com/events/MbFm8MerHKAn5dd8XfRTTK?videoPreview=12025-03-12T15:00:00+00:004885.04Logica UniversalisPresenting the 2nd edition of the book "Institution-independent Model Theory" that has just been published. This will not be a technical presentation. I will talk a bit about the history of this book, mainly from a personal perspective, about its topic, mindset, structure and novelties with respect to the previous edition from 2008. https://cassyni-user-files-prod.s3.amazonaws.com/SHhfDw2K8KBgGYn2D95Tok https://cassyni.com/events/BDcT3NYwfLcdQedbDzY89B/abstract https://cassyni-user-files-prod.s3.amazonaws.com/LJgCWfed5Pa7XX4vQZo49L https://cassyni.com/events/LbxZ2zMoQQ4dQso8Rgx8eR/abstract https://cassyni-user-files-prod.s3.amazonaws.com/2nQWUKPTA8oRZz5NPsd8uU https://cassyni.com/events/UzyppcMisBUcaD9bVYHBsK/abstract https://cassyni-user-files-prod.s3.amazonaws.com/V5vwBib9XmGxM8NevTnHNN https://cassyni.com/slides/outline/U1gcjF4fzGNTuTKbPZos4R https://cassyni.com/events/U1gcjF4fzGNTuTKbPZos4R/abstract https://cassyni-user-files-prod.s3.amazonaws.com/5QbiyJ2SRcXb1Jc1gFWYut https://cassyni.com/events/U1gcjF4fzGNTuTKbPZos4R?videoPreview=1 Opening Keynote - Fireside Chat with Katina Strauch and Richard Charkin (Charleston Conference)nohttps://cassyni.com/events/U1gcjF4fzGNTuTKbPZos4R?videoPreview=12024-11-11T14:00:00+00:003224.76Part of the nonprofit Annual Reviews organizationFor fifty years, Katina Strauch and Richard Charkin have blazed parallel trails in their respective fields—Katina as the driving force behind the Charleston Conference, and Richard as a titan in the academic and trade publishing world. Now, these two legends will meet, remarkably for the first time, to reflect on critical moments in of triumph and of regret that helped shaped their journeys, and to share their views on the development of librarianship, publishing and the relationship between the two. They will make candid predictions on where we are headed and offer advice to upcoming generations of leaders on how to survive and thrive in an era of rapid change. This conversation promises to be a compelling blend of wisdom, foresight, and candid reflection from two towering figures who have helped shape communication in academia. Image credit: [Leo Heisenberg (Unsplash)](https://unsplash.com/photos/yellow-and-blue-concrete-building-ajxP9gEhu30).https://cassyni-user-files-prod.s3.amazonaws.com/5QbiyJ2SRcXb1Jc1gFWYut https://cassyni.com/slides/outline/6modjrF77aZ9mhLRX1biub https://cassyni.com/events/6modjrF77aZ9mhLRX1biub/abstract https://cassyni-user-files-prod.s3.amazonaws.com/R85cuhfPX3oyXhWa2V4cK8 https://cassyni.com/events/6modjrF77aZ9mhLRX1biub?videoPreview=1 Le French Gut : A Prospective Citizen Science Study of 100,000 participants in Francenohttps://cassyni.com/events/6modjrF77aZ9mhLRX1biub?videoPreview=12025-04-15T00:30:00+00:00408.24Microbiome Virtual International ForumLe French Gut – Le microbiote français is a large-scale national study aiming to explore the links between gut microbiota, diet, environmental factors, and health in the French population. The objective is to collect and analyze 100,000 stool samples from adults—and soon from children and teenagers. Participation is entirely home-based, involving self-collected stool samples, online questionnaires, and linkage with the French national health data system. To achieve this large-scale recruitment target, we adapted both pre-analytical and analytical platforms to ensure scalability, robustness, and adherence to high-quality standards. Recruitment strategies and communication channels were also diversified and optimized to effectively engage a broad population. This project will help to : i) advance our understanding of how environmental factors—including diet—shape the gut microbiome, ii) support the development of precision nutrition and personalized medicine strategies, and iii) identify predictive biomarkers of chronic diseases. Launched in 2022, the study has already enrolled over 25,000 participants as of March 2025. In this presentation, we will provide an overview of the project and discuss the scientific, technical, and operational challenges involved in its implementation. https://cassyni-user-files-prod.s3.amazonaws.com/R85cuhfPX3oyXhWa2V4cK8 https://cassyni.com/events/EBXhS6wyhSrzGGrtUtTTKb/seminar/qa https://cassyni.com/slides/outline/EBXhS6wyhSrzGGrtUtTTKb https://cassyni.com/events/EBXhS6wyhSrzGGrtUtTTKb/abstract https://cassyni-user-files-prod.s3.amazonaws.com/LU37U39TsXqa7RuYKurah4 https://cassyni.com/events/EBXhS6wyhSrzGGrtUtTTKb?videoPreview=1 Instabilities in viscoelastic fluids: a long storynohttps://cassyni.com/events/EBXhS6wyhSrzGGrtUtTTKb?videoPreview=12025-05-02T15:00:00+00:003782.04Journal of Fluid MechanicsMany real-life fluids are not Newtonian and have to be modelled with something more complex than a single scalar viscosity. In this talk we will look specifically at dilute polymer solutions. We'll see some simple models that capture the essential features of their behaviour, and then investigate how the properties of these models affect the stability of channel flow. The story spans my whole research career so far, from an early theoretical prediction which was later observed in experiments, to a more recent realisation that there is still quite a lot we don't understand. If time permits I will also discuss the latest place the research has taken me, which is neither viscoelastic nor unstable.https://cassyni-user-files-prod.s3.amazonaws.com/LU37U39TsXqa7RuYKurah4 https://cassyni.com/events/GemifXBbtjdUdDLT2aN63X/seminar/qa https://cassyni.com/slides/outline/GemifXBbtjdUdDLT2aN63X https://cassyni.com/events/GemifXBbtjdUdDLT2aN63X/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Gquu8KubjfLyVJhft7dw8J https://cassyni.com/events/GemifXBbtjdUdDLT2aN63X?videoPreview=1 Algorithms for Cislunar SSA and Decision-Makingnohttps://cassyni.com/events/GemifXBbtjdUdDLT2aN63X?videoPreview=12025-04-23T15:00:00+00:004332.48Department of AeronauticsExtension of Space Situational Awareness (SSA) capabilities to Lunar distances generates a wide variety of challenges with existing methods. Electro-optical detection, tracking, initial orbit determination, maneuver detection & reconstruction, and identification of expected transit routes will be reviewed and discussed. Analytical, computational, and empirical results and performance are discussed.https://cassyni-user-files-prod.s3.amazonaws.com/Gquu8KubjfLyVJhft7dw8J https://cassyni.com/slides/outline/9F3eyGUjJsKxsB9YUQkTbT https://cassyni.com/events/9F3eyGUjJsKxsB9YUQkTbT/abstract https://cassyni-user-files-prod.s3.amazonaws.com/YanmatEjHE5v9doFqzndin https://cassyni.com/events/9F3eyGUjJsKxsB9YUQkTbT?videoPreview=1 From Deserts to Coral Reefs: Preserving Microbial Diversity for One Health in the Arabian Peninsulanohttps://cassyni.com/events/9F3eyGUjJsKxsB9YUQkTbT?videoPreview=12025-09-09T14:15:00+00:00706.32Microbiome Virtual International ForumSaudi Arabia is at a crossroads, facing mounting pressures from climate change, rapid development, population growth, and global travel. As outlined in Vision 2030, these challenges intensify strain on ecosystem processes and threaten microbiomes, wider ecosystems, and public health. This presentation examines how preserving microbial diversity in deserts, volcanic fields, coral reefs, and mangroves can address environmental and health challenges by supporting the breakdown of pollution, enhancing food security, preventing disease, and promoting ecosystem restoration. Robust microbiomes underpin the One Health and Planetary Health frameworks, which link environmental resilience to the health of humans, animals, and ecosystems. The newly established Microbial Vault at King Abdullah University of Science and Technology (KAUST) consolidates thousands of microbial isolates from extreme and marine environments, creating a biobank that advances biotechnological innovation, the development of new medicines, and health research. Through the protection and application of this microbial diversity, Saudi Arabia has the potential to become a leading example in One Health, sustainability, and pandemic preparedness.https://cassyni-user-files-prod.s3.amazonaws.com/YanmatEjHE5v9doFqzndin https://cassyni.com/events/VVD69rGxGE8p3jQqkimkiR/abstract https://cassyni-user-files-prod.s3.amazonaws.com/95YKp6NHCUR7j4WbhmBPn6 https://cassyni.com/events/S2frq4kHC2GB237H74PoBb/seminar/qa https://cassyni.com/slides/outline/S2frq4kHC2GB237H74PoBb https://cassyni.com/events/S2frq4kHC2GB237H74PoBb/abstract https://cassyni-user-files-prod.s3.amazonaws.com/4z4Y7M9iZfDgm6TJj5UEDU https://cassyni.com/events/S2frq4kHC2GB237H74PoBb?videoPreview=1 Accelarating Medical Insights with RAG: From Patient Data to Precision Carenohttps://cassyni.com/events/S2frq4kHC2GB237H74PoBb?videoPreview=12025-05-22T17:00:00+00:003414.04NoneIn this seminar, we will explore how Language Model (LLM) technology coupled with Retrieval Augmented Generation (RAG) systems revolutionizes healthcare by facilitating swift access to academic studies and diagnostic information. By employing these advanced AI tools, doctors can efficiently recap pertinent research findings and diagnoses, expediting the diagnostic process. This innovative approach enhances medical decision-making, streamlines patient care, and ultimately improves health outcomes. We delve into practical applications, discussing how LLMs and RAG systems empower healthcare professionals to navigate vast repositories of medical knowledge effortlessly. Emphasizing the transformative potential of these technologies, we envision a future where rapid access to critical information becomes synonymous with superior patient care. Taliya Weinstein, Programming Chair of the Data Science for Health in Africa Workshop 2025 from SisonkeBiotik will chair this seminar. Image credit: [Hush Naidoo Jade Photography (Unsplash)](https://unsplash.com/photos/black-and-gray-stethoscope-yo01Z-9HQAw).https://cassyni-user-files-prod.s3.amazonaws.com/4z4Y7M9iZfDgm6TJj5UEDU https://cassyni.com/events/5HSUtMaEknzut3ezpwUTJ5/seminar/qa https://cassyni.com/slides/outline/5HSUtMaEknzut3ezpwUTJ5 https://cassyni.com/events/5HSUtMaEknzut3ezpwUTJ5/abstract https://cassyni-user-files-prod.s3.amazonaws.com/REZL3gA6ipDGHi6xk3KScW https://cassyni.com/events/5HSUtMaEknzut3ezpwUTJ5?videoPreview=1 A frequency-based hierarchy of dynamical models in cislunar space: leveraging periodically and quasi-periodically perturbed models, An attempt to build a dynamical catalog of present-day solar system co-orbitalsnohttps://cassyni.com/events/5HSUtMaEknzut3ezpwUTJ5?videoPreview=12025-06-20T13:00:00+00:003858.8Celestial Mechanics and Dynamical AstronomyUnderstanding the applicability of different dynamical models within cislunar space is a useful yet challenging problem. The current work constructs a hierarchy of dynamical models leveraging a common rotating reference frame that accommodates multiple dynamical models. In such a formulation, the Higher-Fidelity Ephemeris Model (HFEM) is approximated as quasi-periodically perturbed model with multiple frequencies in addition to the autonomous Circular Restricted Three-Body Problem (CR3BP) dynamics. Then, different intermediate models are evaluated within the hierarchy in terms of the types and numbers of the incorporated frequencies. The analysis focuses on three main topics. Firstly, coherent solar gravity modeling is properly defined with analytical and visual criteria that serve as useful metrics in assessing intermediate models. Secondly, two periodically perturbed models, i.e., Quasi Bi-Circular Problem (QBCP) and Hill Restricted Four-Body Problem (HR4BP), are investigated within the common rotating reference frame. The capabilities and limitations of these two models within the hierarchy between the CR3BP and HFEM are examined, focusing on the similarities and differences in the models. Thirdly, novel quasi-periodically perturbed models are introduced. Leveraging the insight from Hill's lunar theory, two models are designed, denoted as In-plane Quasi-Hill Restricted Four-Body Problem (I-QHR4BP) and Out-of-plane Quasi-Hill Restricted Four-Body Problem (O-QHR4BP). These two models selectively introduce the eccentricity between the Earth-Moon system and the inclination of the lunar orbit with respect to the Earth ecliptic plane, respectively, in addition to the HR4BP. The global characteristics of these new models are analyzed within the common rotating reference frame. The capabilities of multiple models within the model hierarchy are analyzed for two sample transition cases from the CR3BP to HFEM: $L_2$ Lagrange point and the $L_2$ 9:2 synodic halo orbit. In this talk, we will present a full study of the 1:1 mean-motion resonance in the Solar System. We calculated stability points applying a resonant semi-analytic theory valid for any value of eccentricity or inclination. The location of each equilibrium point changes as the orbital elements of an object change, which led us to map the location of them. For the case of low inclination and low eccentriciy we recovered the known L4 and L5 points. The three global types of orbits for this resonance; Tadpoles, Quasi-satellites and Horseshoes, vary as a function of the orbital elements, even disappearing for some cases. In order to build a catalog of real co-orbital object, we filteres the NASA Horizons minor-body catalog inside the maximum resonant width and analyzed which objects are indeed in resonance. In total, we found 173 objects to be in co-orbital resonant motion with Solar System planets excluding Jupiter. We were able to recover all the already knoen objects and to confirm the resonant state of some new ones. As highlights, Mercury remains to be the only planet with zero known co-orbitals and no L5 Earth Trojan has been discovered so far.https://cassyni-user-files-prod.s3.amazonaws.com/REZL3gA6ipDGHi6xk3KScW https://cassyni.com/events/4J9GnzHBsstmDHpziy18VB/seminar/qa https://cassyni.com/slides/outline/4J9GnzHBsstmDHpziy18VB https://cassyni.com/events/4J9GnzHBsstmDHpziy18VB/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Hesebsn9vJ6ntM9rxfaFGS https://cassyni.com/events/4J9GnzHBsstmDHpziy18VB?videoPreview=1 Thieme Chemistry Journal Awardeesnohttps://cassyni.com/events/4J9GnzHBsstmDHpziy18VB?videoPreview=12025-07-17T08:00:00+00:006675.0Thieme GroupJoin us on Thursday, July 17, 2025 at 10:00 AM CEST for a special Cheminar hosted by Thieme, featuring the 2025 Thieme Journal Awardees. This event will be chaired by Prof. Xin-Yuan Liu, Synthesis board member and Chair Professor at the Southern University of Science and Technology. We’re proud to host three outstanding early-career researchers, recognized for their contributions to the field of synthetic chemistry, catalysis and materials science: 🔹 Dr. Adam Noble, University of Bristol 🔹 Dr. Allegra Franchino, Durham University 🔹 Dr. Stephen Fielden, University of Birmingham Don’t miss your chance to hear from these rising stars in synthetic chemistry and discover their work. https://cassyni-user-files-prod.s3.amazonaws.com/Hesebsn9vJ6ntM9rxfaFGS https://cassyni.com/events/N5WeaE5y5ikkNrLzzWkCDK/seminar/qa https://cassyni.com/slides/outline/N5WeaE5y5ikkNrLzzWkCDK https://cassyni.com/events/N5WeaE5y5ikkNrLzzWkCDK/abstract https://cassyni-user-files-prod.s3.amazonaws.com/FSQfXkc4AtktQmANUneC4n https://cassyni.com/events/N5WeaE5y5ikkNrLzzWkCDK?videoPreview=1 Flow Instability and Transitionnohttps://cassyni.com/events/N5WeaE5y5ikkNrLzzWkCDK?videoPreview=12025-06-25T08:00:00+00:004907.16Nektar++ Development TeamThermoacoustic instabilities present a critical challenge in the design of modern aero-engines, as the interaction between unsteady heat release and acoustic waves can compromise performance and safety. This talk presents a hybrid framework that utilizes the Nektar++ spectral/hp element platform to combine high-fidelity large eddy simulation (LES) with acoustic perturbation equations (APE) for the predictive modelling of combustion-driven noise and instabilities. This approach allows for a computationally efficient analysis of the underlying flow–acoustic coupling mechanisms in realistic combustor configurations. Validation against experimental data and canonical test cases demonstrates the framework's ability to capture key flow features and flame–acoustic interactions. This approach is well-suited to assessing thermoacoustic stability in industrially relevant geometries and operating conditions. This talk explores the structure of the laminar–turbulent boundary in square duct flow at moderate Reynolds numbers. Working within a symmetric subspace, I identify several streamwise-localised invariant solutions that reside on the laminar–turbulent edge, some of which are edge states in the dynamical systems sense. These solutions, while dynamically inaccessible in the full space due to symmetry-breaking perturbations, appear to be embedded within the turbulent attractor. This suggests that symmetry constraints act as a geometric slice through the attractor, raising a provocative question: What happens when you cut a turbulent attractor? Does it bleed asymmetry, or leave coherent structures pinned to the edge? To address this, I visualise the dynamics near the edge using symmetry reduction techniques based on the method of slices (specifically, the Zero Fourier Mode slice) and construct phase-space projections using bases formed from leading eigenfunctions. These projections offer a low-dimensional window into the high-dimensional dynamics, revealing heteroclinic connections, local edge states, and the geometric complexity of the edge manifold. The results highlight both the insight and the difficulty of navigating turbulence in high-dimensional spaces, and the crucial role of projection techniques in decoding its underlying structure.https://cassyni-user-files-prod.s3.amazonaws.com/FSQfXkc4AtktQmANUneC4n https://cassyni.com/slides/outline/2KaUitCyXQc6fpLwyPDTwT https://cassyni.com/events/2KaUitCyXQc6fpLwyPDTwT/abstract https://cassyni-user-files-prod.s3.amazonaws.com/BsQX2LgCfBTZ2GN2GyXVdx https://cassyni.com/events/2KaUitCyXQc6fpLwyPDTwT?videoPreview=1 Vibrational Control: A Mysterious Stabilization Mechanism In Insect Flightnohttps://cassyni.com/events/2KaUitCyXQc6fpLwyPDTwT?videoPreview=12025-06-24T08:00:00+00:001219.6NODYSInsect flight has been a puzzle for aeronautical engineers and biologists for a century, particularly its flight stability. Over the past two decades, there has been a near-consensus among the biology and the engineering communities that insects are unstable at hover. This widely accepted result is based on direct averaging of the flight dynamics over the flapping cycle. From a different perspective, it is well-known to dynamicists that an oscillatory system (such as the inverted pendulum) may gain stability without feedback through a phenomenon called vibrational stabilization. In the honor of the 70th birthday of the great Pontryagain, Agrachev and Gamkrelidze developed a new calculus for time-varying systems: the chronological calculus. Using this less-known calculus, we showed a hidden passive stabilization mechanism that insects exploit through their natural wing oscillations: vibrational stabilization. The oscillations of an insect’s body around the hovering equilibrium naturally stabilizes its flight dynamics, similar to the inverted pendulum. This stabilization technique cannot be captured using the direct averaging approach, commonly used in literature. It is a fascinating design by Nature where the flapping of the insect wings, that is inevitably needed to create an aerodynamic force for lifting, naturally provides stability for free without feedback. We also present another intriguing application of vibrational control in flight: Near stall, when the aileron sensitivity drops significantly, a nonlinear interaction between the elevator and the aileron (in the form of a 90-degree-phased high-frequency oscillations) can produce about ten times as much roll as that of the conventional roll input (ailerons). This mechanism may have a significant impact on both civil and military aviation, as it resolves two chronic problems: the loss of control problem near stall which is known to be the number one factor in fatal accidents worldwide in the last ten years; and the low-speed maneuverability issues in fighter jets. https://cassyni-user-files-prod.s3.amazonaws.com/BsQX2LgCfBTZ2GN2GyXVdx https://cassyni.com/slides/outline/DBqmjvSXBUnaC6AyavT9tH https://cassyni.com/events/DBqmjvSXBUnaC6AyavT9tH/abstract https://cassyni-user-files-prod.s3.amazonaws.com/F2AtC8wnWiw1QN99tWiCge https://cassyni.com/events/DBqmjvSXBUnaC6AyavT9tH?videoPreview=1 AI through a Te Ao Māori lens: Friend or foenohttps://cassyni.com/events/DBqmjvSXBUnaC6AyavT9tH?videoPreview=12023-09-18T23:00:00+00:003180.68Business SchoolThis seminar explores the implications of Artificial Intelligence (AI) through a Te Ao Māori lens, arguing that AI, if developed without diverse input, risks exacerbating existing systemic biases. The analysis draws parallels between historical power imbalances within Aotearoa (New Zealand)'s criminal justice system, where Māori consistently experience disproportionate disadvantage compared to Pākehā (European New Zealanders) due to laws and systems shaped by a narrow demographic. This historical context informs an examination of current AI development, noting that AI tools deployed in criminal justice for predicting offending, sentencing, and facial recognition have demonstrated biased and incorrect outcomes, particularly affecting people of colour and women. This bias is attributed to inefficient and non-representative training data, compounded by a lack of diverse representation within the demographic developing these technologies. The core problem identified is the concentration of decision-making power within a single group, leading to systems that primarily reflect and protect that group's interests. Achieving "trustworthy AI" necessitates a paradigm shift towards broad collaboration and shared power, a concept historically exemplified by the Tiriti o Waitangi (Treaty of Waitangi) as an early model of inclusive governance. AI itself, by facilitating global connectivity, presents an unprecedented opportunity to implement collaborative decision-making throughout its lifecycle. This approach, conceptualized as an "evolutionary" process akin to the koru symbol, ensures the integration of diverse insights, leading to truly representative and responsible technological advancements that transcend mere revolutionary cycles. This model emphasizes human insight, distinct from AI's data aggregation, as crucial for guiding technology responsibly.https://cassyni-user-files-prod.s3.amazonaws.com/F2AtC8wnWiw1QN99tWiCge https://cassyni.com/events/Ff5nyLg9NmZ4Z2eY8cMncD/seminar/qa https://cassyni.com/slides/outline/Ff5nyLg9NmZ4Z2eY8cMncD https://cassyni.com/events/Ff5nyLg9NmZ4Z2eY8cMncD/abstract https://cassyni-user-files-prod.s3.amazonaws.com/6ZS8KZtp5c6j917bFDqrnA https://cassyni.com/events/Ff5nyLg9NmZ4Z2eY8cMncD?videoPreview=1 The motion of a bubble in a non-uniform Hele-Shaw flownohttps://cassyni.com/events/Ff5nyLg9NmZ4Z2eY8cMncD?videoPreview=12025-07-29T08:00:00+00:002744.8Royal Society PublishingWe consider the propagation of a bubble in a non-uniform Hele-Shaw flow. We focus on a distinguished limit in which the bubble is approximately circular in plan view and its velocity is determined by a net force balance incorporating the Hele-Shaw viscous pressure and drag due to the thin films separating the bubble from the cell walls. We find that the instantaneous bubble velocity is the same as that for a bubble in a uniform flow given by the background fluid velocity evaluated at the bubble centre. We apply the model to common microfluidic components, such as a T-junction and injection sources and sinks. Using the same methodology, we derive approximate solutions for the motion of a bubble in more complicated domains including walls or obstacles. We validate the approximate approach with two test cases in which we can find the full solution analytically. First, we consider the effect of an impermeable wall on a bubble in a stagnation-point flow. Second, we consider the motion of a bubble around a circular obstacle. In both cases, the bubble deviates notably from the streamlines of the background flow only when it is very close to the wall or the obstacle.https://cassyni-user-files-prod.s3.amazonaws.com/6ZS8KZtp5c6j917bFDqrnA https://cassyni.com/slides/outline/CCYZeZ9UJZgRXLLyUwyq5P https://cassyni.com/events/CCYZeZ9UJZgRXLLyUwyq5P/abstract https://cassyni-user-files-prod.s3.amazonaws.com/NT9y2iqYDpurM7iqbtuiHk https://cassyni.com/events/CCYZeZ9UJZgRXLLyUwyq5P?videoPreview=1 Building a Digital Culture through Digital Transformation and Upskilling of Existing Workforcenohttps://cassyni.com/events/CCYZeZ9UJZgRXLLyUwyq5P?videoPreview=12020-10-13T23:00:00+00:003531.64Business SchoolDigital transformation and workforce upskilling are critical to addressing challenges posed by evolving technology, automation, and dynamic client expectations. The necessity for change is driven by the disruption of traditional approaches, the prevalence of unstructured data, and the need to deliver higher quality, more efficient client solutions at a lower cost. This study outlines a comprehensive approach to building a digital culture and enhancing digital capabilities within a large professional services firm. A two-pronged strategy involving both business-led and citizen-led innovation was implemented. Foundational technology upgrades provided a uniform baseline for all employees, while agile methodologies, including scaled agile framework (SAFe) principles, were adopted to foster a culture of openness and innovation. Citizen-led upskilling was facilitated through a Digital Fitness app for individual digital IQ assessment, Digital Academies targeting over 80% of the workforce with data analytics and visualization skills, and Digital Accelerators providing deep-dive training in areas like design thinking, machine learning, and AI. A Digital Lab was established to centralise knowledge, foster collaboration, and enable the sharing and reuse of digital assets globally. Key outcomes demonstrate significant engagement and efficiency gains: 95% of the Australian and New Zealand workforce completed Digital Fitness assessments, and over 90% of the Assurance practice was upskilled. The Digital Lab accumulated over 5,000 contributions of reusable intellectual property. Business-led automation initiatives saved over 20,000 hours locally in 18 months, including a financial scenario application and an expense management solution that saved over $350,000 in time. These efforts cultivate a continuous learning mindset and enable a cultural shift that empowers employees to embrace new ways of working and problem-solving, enhancing overall business value and societal impact.https://cassyni-user-files-prod.s3.amazonaws.com/NT9y2iqYDpurM7iqbtuiHk https://cassyni.com/slides/outline/LLWrmwhTDMJwaPJcLqZqF https://cassyni.com/events/LLWrmwhTDMJwaPJcLqZqF/abstract https://cassyni-user-files-prod.s3.amazonaws.com/AuxAsaitTY9GgCUXNrw9yp https://cassyni.com/events/LLWrmwhTDMJwaPJcLqZqF?videoPreview=1 Aptamer-Enabled Discovery, Detection, and Clinical Analysis of Hepatocellular Exosomal Biomarkersnohttps://cassyni.com/events/LLWrmwhTDMJwaPJcLqZqF?videoPreview=12025-04-16T06:00:00+00:004341.68The Pharmacological Research family of journalsExosomes are intercellular messengers that carry abundant membrane proteins and are believed to be an important resource of disease-related biomarkers. In biomarker studies, the development of molecular probes is the basic step to developing detection and analysis strategies, whereas it is largely impeded by the complexity of membrane proteins. The aptamer is a type of spotlighted molecular probe that is generated via in vitro selection of oligonucleotides. Many analytical methods have been developed using aptamers for analyzing proteins and other molecules. Particularly, the cell-based in vitro selection provided an effective strategy to screen molecular probes of aptamers for membrane protein investigations. The most cutting-edge aptamer selection technologies involve expanded artificial nucleotides and modified nucleotides to deal with the desire to introduce chemical diversity and structural diversity of the selected aptamers. Along with the improved in vitro selection procedure, such as Particle Display technology, the efficiency of aptamer selection has been largely improved. The present work is to exploit the artificial and modified nucleotide system, and the particle display technology to develop particle display-based aptamer in situ selection against exosomal membrane proteins (PD-Exosome-AISS). Several aptamers with outstanding affinity and specificity were obtained, and their target proteins were elucidated. Those potential biomarkers are now being investigated further for their value in clinical diagnostics and other biomedical applications.https://cassyni-user-files-prod.s3.amazonaws.com/AuxAsaitTY9GgCUXNrw9yp https://cassyni.com/slides/outline/AiezjmEfnusaoKrSXUK8hs https://cassyni.com/events/AiezjmEfnusaoKrSXUK8hs/abstract https://cassyni-user-files-prod.s3.amazonaws.com/7x4JzYAyvFUMwDUVK5iAkv https://cassyni.com/events/AiezjmEfnusaoKrSXUK8hs?videoPreview=1 Predictive Genome-Resolved Biosurveillance Reveals Ecological Drivers of Antimicrobial Resistance and Pathogenic Potential in Urban Microbiomesnohttps://cassyni.com/events/AiezjmEfnusaoKrSXUK8hs?videoPreview=12026-05-12T14:00:00+00:00973.56Microbiome Virtual International ForumUrban infrastructures, including hospitals, ambulances, wastewater systems, and public transport, form interconnected microbial ecosystems that can facilitate the persistence and circulation of antimicrobial resistance (AMR) and pathogenic organisms. However, environmental microbiome surveillance remains largely descriptive and rarely integrates genome-resolved reconstruction with predictive ecological modeling capable of quantifying microbial stability, contamination dynamics, and pathogen-associated risk across environments. Here we present a predictive genome-resolved biosurveillance framework that combines metagenome assembly, functional annotation, ecological analysis, and machine learning–driven simulations to investigate microbial dynamics across urban infrastructures. Using the GRUMB workflow, we analyzed 767 publicly available shotgun metagenomes collected from hospital interiors, hospital sewage systems, ambulances, and public transport environments. High-quality reads were assembled into more than 10,000 metagenome-assembled genomes (MAGs), dereplicated into species-level representatives, and annotated for antimicrobial resistance genes and virulence factors. Genome-resolved abundance profiles enabled detailed ecological characterization of microbial communities and identification of pathogen-associated taxa across environments. Supervised machine-learning models accurately classified environmental origin based on microbial composition, revealing strong environment-specific microbial signatures. To investigate cross-environment microbial influence, we implemented synthetic donor–recipient mixing simulations that model contamination gradients and quantify ecological resilience, dominance relationships, and minimal detectable contamination thresholds. Our analyses reveal pronounced ecological structuring across urban microbiomes. Hospital sewage emerges as a dominant microbial donor, whereas hospital environments exhibit greater compositional stability and resilience to microbial intrusion. Functional analyses further suggest that resistance and virulence determinants form coordinated trait architectures that shape resilience–dominance trade-offs across built environments. Together, this genome-resolved and simulation-driven framework advances microbiome biosurveillance from descriptive profiling toward predictive ecological modeling. These results provide quantitative indicators for monitoring AMR dissemination and improving infrastructure-level biosurveillance within a One Health framework.https://cassyni-user-files-prod.s3.amazonaws.com/7x4JzYAyvFUMwDUVK5iAkv https://cassyni.com/events/4H5cT4hWaAh9cigzAgTggD/seminar/qa https://cassyni.com/slides/outline/4H5cT4hWaAh9cigzAgTggD https://cassyni.com/events/4H5cT4hWaAh9cigzAgTggD/abstract https://cassyni-user-files-prod.s3.amazonaws.com/5WN1zH4DyqLJhVrCviBiFp https://cassyni.com/events/4H5cT4hWaAh9cigzAgTggD?videoPreview=1 Logic and the Social Worldnohttps://cassyni.com/events/4H5cT4hWaAh9cigzAgTggD?videoPreview=12025-08-13T14:00:00+00:004257.32Logica UniversalisThis work is motivated by the perception that there is a gap between two communities. One community consists of mathematicians and logicians. The other community consists of social scientists and philosophers. The second community is keenly interested in the problems of society. But it lacks the tools to understand the way in which mathematical and logical tools help with these problems. The first community does have the technical tools, or has the expertise to easily adapt the existing tools to social problems. But they lack the interest. Thus important work on the problems of society is simply not being done. Thus I am appealing to people to address this lacuna.https://cassyni-user-files-prod.s3.amazonaws.com/5WN1zH4DyqLJhVrCviBiFp https://cassyni.com/events/F9LuU6w4EEsd8zX1nDhNd3/seminar/qa https://cassyni.com/slides/outline/F9LuU6w4EEsd8zX1nDhNd3 https://cassyni.com/events/F9LuU6w4EEsd8zX1nDhNd3/abstract https://cassyni-user-files-prod.s3.amazonaws.com/9xLQnWSGnuZKFSw3X3vG9C https://cassyni.com/events/F9LuU6w4EEsd8zX1nDhNd3?videoPreview=1 Chronic kidney disease. How early is too early?nohttps://cassyni.com/events/F9LuU6w4EEsd8zX1nDhNd3?videoPreview=12025-10-14T08:30:00+00:00504.4North West London Kidney CareWhat is early-stage CKD? How to identify patients with early-stage CKD Why is early diagnosis important? What can we do about it? https://cassyni-user-files-prod.s3.amazonaws.com/9xLQnWSGnuZKFSw3X3vG9C https://cassyni.com/events/9iDFxapHQCnYk8GnBJhadb/abstract https://cassyni-user-files-prod.s3.amazonaws.com/7fNGTYPkF41EGFR9DYqW86 https://cassyni.com/slides/outline/HdhqGhn8XxhYoDdAn9AAfP https://cassyni.com/events/HdhqGhn8XxhYoDdAn9AAfP/abstract https://cassyni-user-files-prod.s3.amazonaws.com/W5uGKERzAcVppVMcs4DZqp https://cassyni.com/events/HdhqGhn8XxhYoDdAn9AAfP?videoPreview=1 "Vibrational" Electromagnetics in Metamaterialsnohttps://cassyni.com/events/HdhqGhn8XxhYoDdAn9AAfP?videoPreview=12025-06-17T07:00:00+00:003635.72ETOPIMInspired by Kapitza’s inverted pendulum problem, we have been exploring how such phenomena can be brought into the field of electromagnetic and optical metamaterials. I will present several case studies we have explored so far. Vibrational electromagnetics in metamaterials: The problem of an inverted pendulum with a vibrating base has been an exciting topic in mechanics since long ago [1]. It is known that a stationary inverted pendulum is at an unstable equilibrium. However, the structure becomes stable when the base is vibrated with a small amplitude but high frequency. In 1951, Pyotr Kapitza developed a comprehensive theory describing quantitatively the physics behind this mechanical problem and providing the necessary stability conditions [2, 3]. His work on this theory launched the fields of vibrational mechanics and vibrational resonance with applications in various fields of science and technology. Inspired by Kapitza’s work, in my group we have been exploring how such phenomena can be brought into the fields of electromagnetics and optics. In other words, can an “unstable” electromagnetic problem be made “stable” by adding a small-amplitude, high-frequency modulation of a parameter? We have been investigating several scenarios for this purpose. One of these scenarios is the case of LC circuit with negative (non-Foster) capacitance [4]. Such a circuit exhibits instability due to the presence of negative C. However, we have shown theoretically that a properly time-modulated inductor L(t) can indeed make the circuit stable even in the presence of negative C [4]. This problem has led us to the next scenario of “Temporal Illusion”, in which a judiciously selected time-varying permittivity can imitate light-matter interaction in an object with unusual permittivity values [5]. Another case we are exploring is how monochromatic evanescent waves in Drude-negative-permittivity material can be significantly altered into monochromatic propagating waves by having periodic high-spatial-frequency distributions of positive-negative inhomogeneity. More cases are in progress now. In this talk, I will present an overview of our most recent results and discuss some of the salient features of these phenomena inspired by the Kapitza inverted pendulum problem. https://cassyni-user-files-prod.s3.amazonaws.com/W5uGKERzAcVppVMcs4DZqp https://cassyni.com/slides/outline/VyuwRnxFWQYQgtrykVitoX https://cassyni.com/events/VyuwRnxFWQYQgtrykVitoX/abstract https://cassyni-user-files-prod.s3.amazonaws.com/2JS2TnHiUcMxMAQmtkd7Tt https://cassyni.com/events/VyuwRnxFWQYQgtrykVitoX?videoPreview=1 ENZ materials: Optimal designs for low-loss composites and near-field antennasnohttps://cassyni.com/events/VyuwRnxFWQYQgtrykVitoX?videoPreview=12025-06-18T03:00:00+00:001809.04ETOPIMSurprising phenomena for many applications can be enabled at wavelengths where the real part of a material’s permittivity is near zero. A key hurdle for many of these phenomena at optical frequencies is material loss, with typical material quality factors of 5 or smaller. We use the theory of composites to identify a pathway, using typical materials, to design ENZ metamaterials with substantially smaller losses, offering order-of-magnitude improvements in material quality factors at the ENZ point. We also identify a new application for ENZ materials: near-field antennas. “Dual-polarizability” designs enable dramatic enhancements of Purcell factors, at a fixed quality factor, increasing the exponent that dictates enhancement rate as a function of minimum feature size. Materials with dielectric and ENZ materials can provably outperform any dielectric-only designs.https://cassyni-user-files-prod.s3.amazonaws.com/2JS2TnHiUcMxMAQmtkd7Tt https://cassyni.com/slides/outline/YT9xfDBshhJu3qLYJBdXXT https://cassyni.com/events/YT9xfDBshhJu3qLYJBdXXT/abstract https://cassyni-user-files-prod.s3.amazonaws.com/59AFUiFyzzYUHd6SuVXQpE https://cassyni.com/events/YT9xfDBshhJu3qLYJBdXXT?videoPreview=1 Hyperbolic quantum processornohttps://cassyni.com/events/YT9xfDBshhJu3qLYJBdXXT?videoPreview=12025-06-19T01:00:00+00:001972.88ETOPIMAchieving strong coherent interaction between qubits separated by large distances holds the key to many important developments in quantum technology, including new designs of quantum computers, new platforms for quantum simulations and implementation of large-scale quantum optical networks. However, the inherent mismatch between the spatial dimensions of a quantum emitter and the photon wavelength fundamentally limits the transmission of quantum entanglement over long distances. In our work [1] we demonstrate that long-range qubit entanglement can be readily achieved when qubit interactions are mediated by optical polariton waves in a hyperbolic material, due to the phenomenon of the Hyperbolic SuperResonance. We show that in this regime the resulting quantum gate fidelity that exceeds 99%, can be achieved with the use of qubits based on well-known deep donors in silicon when their interactions are mediated by polariton fields in the substrate formed by a hyperbolic material (such as e.g., hexagonal boron nitride (hBN)). At the physical level (see Fig. 1) the proposed system is essentially a silicon-based optoelectronic chip, and it’s readily accessible to the existing methods of semiconductor nanofabrication, leading to the integration densities of well over 108 qubits/cm2 , and therefore opening the way to scalable and fault-tolerant error correction in quantum computation. Furthermore, we demonstrate that, due to the optical time scales that define the duration of the gate operation in the proposed system, and sub-nanosecond time of the decoherence in deep donors in silicon at the liquid nitrogen temperatures,[16] the proposed Hyperbolic Quantum Processor does not require dilution refrigeration and therefore offers a pathway to bring quantum computation to the realm of conventional engineering. https://cassyni-user-files-prod.s3.amazonaws.com/59AFUiFyzzYUHd6SuVXQpE https://cassyni.com/events/R3RtxxV17q1PHo9dk21u5P/abstract https://cassyni-user-files-prod.s3.amazonaws.com/7Ev4vckxsBttPpbg52YedU https://cassyni.com/events/R3RtxxV17q1PHo9dk21u5P?videoPreview=1 Localization of wave propagation in non-symmetric rotor chain structures exhibiting dual topological statesnohttps://cassyni.com/events/R3RtxxV17q1PHo9dk21u5P?videoPreview=12025-06-18T23:00:00+00:00798.88ETOPIMThe study investigates wave localization and vibration control in rotor chain structures exhibiting dual topological states, addressing a gap in models that simultaneously host zero-frequency and finite-frequency topological modes. Building on prior rotor chain systems with single-degree-of-freedom rotors, the analysis introduces a modified chain with two degrees of freedom per unit cell, incorporating rotatable pendulums connected by bars with stiffness KB and rotational springs KR. This configuration breaks inversion symmetry and opens finite-frequency band gaps. The compatibility matrix, extended to a 4×2 form due to multiple extensions, and the global stiffness matrix are employed to characterize the system’s topological properties. Challenges arising from the non-square compatibility matrix and lack of strict chiral symmetry in the stiffness matrix are addressed by decoupling rotational and bar extensions for zero-frequency states and using eigenvector phase differences to identify finite-frequency topological invariants. Results demonstrate that the topological polarization winding number depends on the average rotor angle θ and is gauge-dependent, dictating the localization of floppy modes at lattice edges. Variation of parameters KB and KR reveals distinct effects on band gaps and topological interface modes, with KR acting analogously to second-nearest-neighbor coupling in SSH models and lifting zero-frequency modes to finite frequencies. Experimental validation confirms zero-frequency edge mode localization without bulk wave propagation. The findings provide a framework for designing mechanical metamaterials with tunable dual topological states, offering potential applications in vibration isolation and waveguiding.https://cassyni-user-files-prod.s3.amazonaws.com/7Ev4vckxsBttPpbg52YedU https://cassyni.com/slides/outline/8FPMPiVACGAzt9ahNQLE77 https://cassyni.com/events/8FPMPiVACGAzt9ahNQLE77/abstract https://cassyni-user-files-prod.s3.amazonaws.com/UhJ4Fy9fpyUgbGPha5mrut https://cassyni.com/events/8FPMPiVACGAzt9ahNQLE77?videoPreview=1 How do forest regeneration methods impact the soil microbial communities in Boreal zonesnohttps://cassyni.com/events/8FPMPiVACGAzt9ahNQLE77?videoPreview=12025-07-09T12:00:00+00:00685.04NoneForests play a pivotal role in the Finnish economy, culture, and heritage. Therefore, ensuring their sustainable use is a priority. One of the strategies adopted by forestry operations is regeneration after felling (clearcutting) achieved either through natural regeneration or plantation. Thus, understanding how microbial communities respond to forestry operations is vital for sustainable forest management and health. In this study, mineral and organic soil samples were collected from different plots across Finland, including natural regeneration areas, plantations, and their respective control sites. Mineral soil samples were stored at -80 °C followed by DNA extraction, and 16S rRNA and ITS amplifications for sequencing afterward. Humic and mineral soil samples were first cleaned by removing roots and rocks then used for CO₂ efflux measurements to inform carbon balance calculations. In addition, mushroom fruiting bodies were collected from each plot during the growing season. The mushrooms were dried at 60 °C, and pre-identified based on their phenotypic features. Soil respiration measurements were recorded from all samples, and over 200 fruiting bodies were identified from the selected plots. Microbial diversity and the conservation of ecosystem functions will be further studied through soil microbiome sequencing and its potential role in plant–microbe interactions. https://cassyni-user-files-prod.s3.amazonaws.com/UhJ4Fy9fpyUgbGPha5mrut https://cassyni.com/events/SWHReTL1j8YPEvxnLsyKYq/seminar/qa https://cassyni.com/slides/outline/SWHReTL1j8YPEvxnLsyKYq https://cassyni.com/events/SWHReTL1j8YPEvxnLsyKYq/abstract https://cassyni-user-files-prod.s3.amazonaws.com/5PK7vGeVmrthcRABaGvRVG https://cassyni.com/events/SWHReTL1j8YPEvxnLsyKYq?videoPreview=1 Double Dragon Genomes Helping Explain Sex Determination of Reptilesnohttps://cassyni.com/events/SWHReTL1j8YPEvxnLsyKYq?videoPreview=12025-08-26T10:00:00+00:005356.16GigaScience PressTwo almost complete and gapless genomes of the sex-changing central bearded dragon (Pogona vitticeps) are published back-to-back to help tackle the mystery of reptile sex determination. This species has an unusual trait for an animal species: whether this lizard grows up to be a male or a female depends not only on genetics but also on the temperature of its nest. This has long made it a useful model to study the biological basis of sex determination, and the advent of huge technological improvements in genomics has finally found a region of the genome and a potential master sex determination gene likely central to male sexual differentiation. The independent verification of this by two different groups using two different approaches making this a much stronger finding. And this is an opportunity to see both groups present, and talk about the technological advances that enabled this to happen.https://cassyni-user-files-prod.s3.amazonaws.com/5PK7vGeVmrthcRABaGvRVG https://cassyni.com/events/P3mpSJKE4Hb1bpKEncDr53/seminar/qa https://cassyni.com/slides/outline/P3mpSJKE4Hb1bpKEncDr53 https://cassyni.com/events/P3mpSJKE4Hb1bpKEncDr53/abstract https://cassyni-user-files-prod.s3.amazonaws.com/P47PLXsMJ2uuwMW8fitukA https://cassyni.com/events/P3mpSJKE4Hb1bpKEncDr53?videoPreview=1 Senseable Citiesnohttps://cassyni.com/events/P3mpSJKE4Hb1bpKEncDr53?videoPreview=12025-12-19T14:00:00+00:003703.44ArtIStE - Artificial Intelligence in Structural EngineeringThis talk investigates how the Internet of Things (IoT) is reshaping urban design and architecture by embedding connectivity into the built environment. Drawing from projects by the MIT Senseable City Lab, it illustrates how data and sensing technologies enable new forms of urban interaction and management. The lecture will critically reflect on the implications of these technologies for energy, mobility, public engagement, and city-making. https://cassyni-user-files-prod.s3.amazonaws.com/P47PLXsMJ2uuwMW8fitukA https://cassyni.com/events/VxrH5sNaChLo6dJpA3nnDj/seminar/qa https://cassyni.com/slides/outline/VxrH5sNaChLo6dJpA3nnDj https://cassyni.com/events/VxrH5sNaChLo6dJpA3nnDj/abstract https://cassyni-user-files-prod.s3.amazonaws.com/CSBs6DjciDt1RbZfjWgsgS https://cassyni.com/events/VxrH5sNaChLo6dJpA3nnDj?videoPreview=1 Biologically Driven Desalination: Advancing Sustainable and Climate-Positive Water Productionnohttps://cassyni.com/events/VxrH5sNaChLo6dJpA3nnDj?videoPreview=12025-10-23T09:00:00+00:003508.96ElsevierGlobal water scarcity continues to escalate, with desalination emerging as a critical solution to secure freshwater supplies. However, conventional desalination technologies such as reverse osmosis and thermal processes remain energy-intensive, costly, and environmentally burdensome due to high carbon emissions, brine disposal, and chemical consumption. This talk introduces biodessalination, a novel and sustainable alternative that leverages selective microorganisms and bio-membranes to achieve efficient salt removal from seawater and brackish sources. The presentation will highlight recent advances in developing immobilized microbial systems and dual bioreactor platforms—one dedicated to cultivating algae and microbial consortia, and another designed for real-time water treatment. This dual approach enhances system resilience, reduces chemical inputs, and extends membrane life. By integrating carbon-capturing microbial pathways, biodessalination not only decreases greenhouse gas emissions but also achieves a negative carbon footprint, positioning it as a climate-positive water innovation. Experimental results and pilot-scale designs will be presented to demonstrate the technology’s potential for scalability, cost-effectiveness, and integration with circular water systems. Applications span municipal desalination plants, industrial water users, and agriculture in water-stressed regions. Biodessalination represents a transformative step beyond the state of the art, redefining desalination as not just a means of providing safe water, but as a sustainable platform for water reuse, resource recovery, and climate resilience.https://cassyni-user-files-prod.s3.amazonaws.com/CSBs6DjciDt1RbZfjWgsgS https://cassyni.com/events/8EKh3nuUtYyPHt2XmxQ7XK/seminar/qa https://cassyni.com/slides/outline/8EKh3nuUtYyPHt2XmxQ7XK https://cassyni.com/events/8EKh3nuUtYyPHt2XmxQ7XK/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Qk8YixcZMPg4UV2SFUNgp6 https://cassyni.com/events/8EKh3nuUtYyPHt2XmxQ7XK?videoPreview=1 The Health of Women Who Are Incarceratednohttps://cassyni.com/events/8EKh3nuUtYyPHt2XmxQ7XK?videoPreview=12026-02-13T15:00:00+00:003721.16Women's Health"Women who are incarcerated often fall through the cracks in terms of health care that meets their unique health and social needs. In correctional systems largely designed with men in mind, and with health outcomes worse than both men in prison and women in the general community, it is a population that needs particular attention. This is why research on the health of women who are incarcerated is so important." - Jessica Gaber, Guest Editor of the Special Collectionhttps://cassyni-user-files-prod.s3.amazonaws.com/Qk8YixcZMPg4UV2SFUNgp6 https://cassyni.com/slides/outline/3oaY6CBKeW7oJWrsA2kCZB https://cassyni.com/events/3oaY6CBKeW7oJWrsA2kCZB/abstract https://cassyni-user-files-prod.s3.amazonaws.com/7vJZjQVGeYo6TeBUPNsc1L https://cassyni.com/events/3oaY6CBKeW7oJWrsA2kCZB?videoPreview=1 Metascience-powered policymakingnohttps://cassyni.com/events/3oaY6CBKeW7oJWrsA2kCZB?videoPreview=12025-06-30T08:00:00+00:006980.96The seminar on metascience-powered policymaking addressed the growing global movement to apply rigorous scientific methods to the evaluation and improvement of research systems. Metascience, or the science of science, is increasingly recognized as essential for enhancing research reproducibility, funding allocation, institutional design, and innovation ecosystems. The UK’s Metascience Unit exemplifies this approach, operating with a modest budget to experiment with peer review processes, funding strategies, and the use of artificial intelligence to optimize research assessment. Key challenges include developing robust, timely indicators of research excellence that extend beyond novelty to encompass implementation, scaling, and real-world impact, as well as fostering diversity, interdisciplinarity, and collaboration within research cultures. European perspectives emphasized the need for experimental funding units to reduce bureaucratic inertia and support transformative, risk-taking research, while African contributions highlighted the critical role of metascience in ensuring research relevance, integrity, and alignment with developmental priorities amid resource constraints. Japan’s experience illustrated how data-driven science policy can strategically align research investment with societal goals, national security, and sustainability under the vision of Society 5.0. New Zealand’s review underscored the necessity of tailoring research assessment to multiple purposes—stewardship, policy needs, knowledge development, and private sector exploitation—and the importance of justifying public research funding to taxpayers. Collectively, these insights demonstrate metascience’s potential to inform evidence-based, adaptive policymaking that enhances the effectiveness, inclusivity, and societal value of global research systems.https://cassyni-user-files-prod.s3.amazonaws.com/7vJZjQVGeYo6TeBUPNsc1L https://cassyni.com/slides/outline/N4SzEJWHn1Z8nHCzSECkQM https://cassyni.com/events/N4SzEJWHn1Z8nHCzSECkQM/abstract https://cassyni-user-files-prod.s3.amazonaws.com/BbpaNXyH3D5P2NqLtr42L6 https://cassyni.com/events/N4SzEJWHn1Z8nHCzSECkQM?videoPreview=1 Evaluating AI Outputs: Ensuring Accuracy and Relevancenohttps://cassyni.com/events/N4SzEJWHn1Z8nHCzSECkQM?videoPreview=12025-07-17T08:00:00+00:003292.36AAMCNot all AI-generated content is created equal—and in medical education, accuracy is everything. In this high-impact session, you’ll learn how to separate fact from fiction, spot misleading AI “hallucinations,” and ensure the content you use or share is credible, relevant, and aligned with your teaching goals. Whether you're just starting with AI or looking to sharpen your evaluation skills, this session will give you the edge you need to use AI responsibly and effectively. Objectives: - Analyze AI outputs to determine alignment with educational goals. - Check AI outputs for accuracy, correctness, and relevance against credible sources. - Triangulate results across multiple AI tools. - Recognize ethical risks such as AI-generated misinformation and biased content. This webinar is part of the AI Skill Building for Medical Educators Webinar Series, hosted by the AAMC. For more information, see [the complete series webpage](https://www.aamc.org/learn-network/affinity-groups/group-educational-affairs/webinar-series-ai-skill-building-medical-educators). CME Information - View the last page of the slide deck for complete instructions on earning CME credit for this recording - CME credit for this learning opportunity is organized by Michigan State University College of Human Medicine Office of Continuing Medical Education - You will be prompted to create an account to obtain credithttps://cassyni-user-files-prod.s3.amazonaws.com/BbpaNXyH3D5P2NqLtr42L6 https://cassyni.com/slides/outline/H7xwmU33PS27PBVeRkVkgD https://cassyni.com/events/H7xwmU33PS27PBVeRkVkgD/abstract https://cassyni-user-files-prod.s3.amazonaws.com/T3ZaZ88ggERqrHNgTT9LjG https://cassyni.com/events/H7xwmU33PS27PBVeRkVkgD?videoPreview=1 African Societies in Development: Critical Challenges and Successes: a Panel Discussionnohttps://cassyni.com/events/H7xwmU33PS27PBVeRkVkgD?videoPreview=12007-02-20T09:00:00+00:004396.96 School of Public PolicyIn celebration of Black History Month, Ivan Allen College, Office of the Dean presented a panel discussion on African Societies in Development. Moderator, Georgia A. Persons, School of Public Policy, made introductions. Panelists and their topics included: Ruth Uwaifo Oyelere, Assistant Professor of Economics, who spoke on "Critical Economic Development Issues for Africa in the 21st century; " Michael Best, Assistant Professor, School of International Affairs who spoke on “Information Technologies and Development Change in Africa;" and Jumbe Sebunya, Senior Advisor, CARE International/USA who spoke on "Challenges of Managing Change in Support of Development in Africa." A newly chartered organization, GT - IDEA (Initiative for Development and Education in Africa), was introduced by Georgia Tech student Karan Chopra. Sue V. Rosser, Dean of Ivan Allen College gave concluding remarks.https://cassyni-user-files-prod.s3.amazonaws.com/T3ZaZ88ggERqrHNgTT9LjG https://cassyni.com/slides/outline/M5D2NCF1hpJM4LqC32SBXK https://cassyni.com/events/M5D2NCF1hpJM4LqC32SBXK/abstract https://cassyni-user-files-prod.s3.amazonaws.com/3Ty5pK8WFG2mHva4XcpL7G https://cassyni.com/events/M5D2NCF1hpJM4LqC32SBXK?videoPreview=1 Linking above- and below-ground trait coordination at community-level to ecosystem & microbial functions under climate changenohttps://cassyni.com/events/M5D2NCF1hpJM4LqC32SBXK?videoPreview=12025-08-05T09:15:00+00:00911.32NoneIncreasing temperatures and droughts are known to affect mountain plant communities, their functional trait,s and life strategies. However, little is known about how communities acclimate to climate change, and how tightly plant responses are linked to responses of the ecosystem and microbial functions.  With a whole-community transplantation experiment, we compared warmed and dried communities transplanted from alpine to subalpine conditions to alpine and subalpine control communities. Five years after transplantation, we found slower growth (e.g. lower leaf nitrogen) and more outsourcing strategies (e.g. lower specific root length) in the warmed alpine communities, probably due to drought stress. While below-ground traits fully acclimated to new subalpine conditions, above-ground traits did not.   Changes in functional traits cascaded to changes in the ecosystem and microbial functions (eg. productivity, decomposition rates, arbuscular colonization, and bacterial biomass). Most of the variance in ecosystem and microbial functions was explained by the above-ground traits and links between traits and ecosystem and microbial functions did not change under treatment. In contrast, the links between below-ground traits and ecosystem and microbial functions were disrupted under climate change. This might challenge our capacity to predict the trajectories of plant and soil communities and their associated ecosystem functions under climate change.https://cassyni-user-files-prod.s3.amazonaws.com/3Ty5pK8WFG2mHva4XcpL7G https://cassyni.com/events/PYT3bcUdu74qRHJkaiLpFF/abstract https://cassyni-user-files-prod.s3.amazonaws.com/NVGLCqATGfSormdk6UaJxE https://cassyni.com/events/8izvD74tjNTD7M23a4X5hX/seminar/qa https://cassyni.com/slides/outline/8izvD74tjNTD7M23a4X5hX https://cassyni.com/events/8izvD74tjNTD7M23a4X5hX/abstract https://cassyni-user-files-prod.s3.amazonaws.com/G3zu4DpupUQDQYoH9enM34 https://cassyni.com/events/8izvD74tjNTD7M23a4X5hX?videoPreview=1 Dilatancy, shear jamming and yielding in frictionless and frictional sphere packingsnohttps://cassyni.com/events/8izvD74tjNTD7M23a4X5hX?videoPreview=12025-11-14T13:00:00+00:004128.72Granular MatterGranular packings, when subjected to shear deformation, exhibit a number of fascinating phenomena, which include dilatancy, shear jamming and yielding. Conventionally, the related phenomena of dilatancy and shear jamming were thought to arise only for frictional grains. Our work has shown that shear jamming can indeed arise for frictionless sphere packings, and depends on the presence of a continuous range of densities over which jamming under compression can occur. Thus, shear jamming and dilatancy occur more broadly than thought, including for frictionless packings. Shear jamming of frictionless spheres also suggests investigation of criticality and marginal stability of the jamming point, in analogy with jamming under compression. The exponents characterizing criticality and marginal stability for shear jamming are found to be the same as jamming under compression. In particular, the force and gap exponents characterising the marginal stability condition are, interestingly, the same as those predicted by the mean field theory of the glass transition, which had previously been verified for isotropic jamming. Detailed analysis of the rigidity transition for shear jamming, both for frictionless and frictional grains, shows that the transition is discontinuous, contrary to some results suggesting a continuous transition, but similar to what is seen in jamming under compression. These results together contribute to a unified view of jamming under shear and compression. Investigations of sphere packings subject to cyclic shear, rather than uniform shear, also exhibit rich phenomenology, in particular with respect to unjamming and yielding behaviour, with the phenomenon of dilatancy playing an interesting and significant role. Recent results these phenomena are summarised. https://cassyni-user-files-prod.s3.amazonaws.com/G3zu4DpupUQDQYoH9enM34 https://cassyni.com/slides/outline/KbCxztGfainbk7yCySQPQ9 https://cassyni.com/events/KbCxztGfainbk7yCySQPQ9/abstract https://cassyni-user-files-prod.s3.amazonaws.com/VZWzscMGwX3pPcp9TBkg1C https://cassyni.com/events/KbCxztGfainbk7yCySQPQ9?videoPreview=1 How Do I Teach Ethics If I Am Not an Ethicist?nohttps://cassyni.com/events/KbCxztGfainbk7yCySQPQ9?videoPreview=12021-06-02T08:00:00+00:00988.0 School of Public PolicyThe integration of ethics education within technical curricula addresses the limitations of standalone ethics courses, which risk marginalizing ethical considerations as peripheral rather than integral to professional practice. Embedding ethics throughout technical instruction fosters ongoing ethical awareness and sensitivity, enabling students to recognize and reflect on ethical issues encountered in their fields. This approach emphasizes that teaching ethics does not require extensive expertise; even minimal ethical knowledge combined with the ability to identify ethical concerns can effectively model ethical reflection for students. Common misconceptions are challenged, including the reduction of ethics to mere compliance and the belief that ethics is purely subjective. Instead, ethics encompasses broader considerations of how actions impact others and involves shared principles that support rational discourse. The Belmont Report’s ethical principles—Respect for Persons, Beneficence, and Justice—offer a foundational framework for ethical reasoning, highlighting individual autonomy, the promotion of welfare alongside harm reduction, and the equitable distribution of benefits and burdens. While these principles do not prescribe definitive solutions, they provide normative constraints that can exclude clearly unethical actions and guide nuanced decision-making. This framework is applicable to complex real-world cases, such as balancing freedom of speech against harm prevention, illustrating the practical relevance of ethical principles in technical and professional contexts. The approach advocates for a dual strategy combining expert-led ethics courses with ethics integration across the curriculum to better prepare students for ethically significant decisions in their careers.https://cassyni-user-files-prod.s3.amazonaws.com/VZWzscMGwX3pPcp9TBkg1C https://cassyni.com/slides/outline/Szw2h8yYAb6SEhVfwKG7p9 https://cassyni.com/events/Szw2h8yYAb6SEhVfwKG7p9/abstract https://cassyni-user-files-prod.s3.amazonaws.com/4FHnFaSdSogUxT75wfxadU https://cassyni.com/events/Szw2h8yYAb6SEhVfwKG7p9?videoPreview=1 Self-Driving Cars and Beyond: Societal Impacts of Autonomous Transportation Systemsnohttps://cassyni.com/events/Szw2h8yYAb6SEhVfwKG7p9?videoPreview=12017-10-13T08:00:00+00:004131.72 School of Public PolicyThis seminar addresses the multifaceted societal impacts of autonomous transportation systems, focusing on near- to medium-term developments and ethical considerations. The discussion highlights imminent legislative changes permitting widespread deployment of self-driving vehicles, including level 3 (human takeover expected) and level 4 (fully autonomous without human intervention) automation. Concerns are raised about the lack of mandated informed consent for experimental deployment of up to a million autonomous vehicles on public roads, emphasizing the need for clear identification of such vehicles to enable public awareness and choice. Human factors challenges are underscored, particularly the risks associated with driver disengagement and mode confusion in semi-autonomous systems, as exemplified by the Joshua Brown Tesla fatality. The panel also explores the complexity of integrating autonomous vehicles into existing infrastructure, noting potential unintended consequences such as increased congestion if vehicle sharing does not occur. Ethical and regulatory dilemmas emerge around the “race to the bottom” among jurisdictions eager to adopt autonomous technologies for economic advantage, often at the expense of thorough testing and safety validation. The aviation sector’s gradual automation, including robotic co-pilots, is presented as a parallel, illustrating augmentation rather than replacement of human operators. Additional challenges include cybersecurity vulnerabilities, passive and active hacking of sensor systems, and the social dynamics of human drivers interacting with autonomous vehicles. The seminar concludes that while autonomous transportation promises significant advances, robust ethical frameworks, informed consent protocols, infrastructure adaptation, and vigilant oversight are critical to ensure public safety and societal acceptance.https://cassyni-user-files-prod.s3.amazonaws.com/4FHnFaSdSogUxT75wfxadU https://cassyni.com/slides/outline/5m43hk9yHuH86wWW4m3yfK https://cassyni.com/events/5m43hk9yHuH86wWW4m3yfK/abstract https://cassyni-user-files-prod.s3.amazonaws.com/WFUA6eAr6jqXpGCu6T683g https://cassyni.com/events/5m43hk9yHuH86wWW4m3yfK?videoPreview=1 How Interdisciplinary is Nano?nohttps://cassyni.com/events/5m43hk9yHuH86wWW4m3yfK?videoPreview=12009-08-25T08:00:00+00:003032.0 School of Public PolicyThis analysis examines the interdisciplinarity of nanoscience and nanoengineering research through comprehensive data mining and science mapping techniques applied to large bibliometric datasets from 1991 to 2008, primarily sourced from the Science Citation Index and complementary engineering and social science databases. Employing text mining tools and principal components analysis, the study maps nanotechnology publications across 175 detailed subject categories, revealing a broad but material science- and chemistry-centric concentration with significant engagement from physics, engineering, and biomedical sciences. An integration metric, developed to quantify interdisciplinarity by assessing the diversity and cognitive distance of cited references within individual papers, indicates that nanotechnology exhibits a relatively high level of interdisciplinarity (integration scores increasing from approximately 0.55 to 0.64 over time), comparable to established interdisciplinary fields such as biochemistry and exceeding more disciplinary-focused areas like mathematics. Citation patterns demonstrate that nanoscience research actively draws upon multiple disciplines, with cross-field knowledge transfer evident but predominantly among closely related fields. Case studies of molecular motor research further illustrate that interdisciplinary collaboration occurs within coherent research communities blending diverse expertise rather than isolated disciplinary silos. These findings underscore nanotechnology’s role as a genuinely interdisciplinary domain, with implications for fostering cross-disciplinary training, research organization, and funding strategies. The developed methodologies and mapping capabilities offer valuable tools for profiling research centers, tracking innovation pathways, and supporting strategic decision-making in emerging technology domains.https://cassyni-user-files-prod.s3.amazonaws.com/WFUA6eAr6jqXpGCu6T683g https://cassyni.com/slides/outline/DAn7PzrqsmaxbX2y2dui5K https://cassyni.com/events/DAn7PzrqsmaxbX2y2dui5K/abstract https://cassyni-user-files-prod.s3.amazonaws.com/HzjxdArYW49FVoFdbaDNVc https://cassyni.com/events/DAn7PzrqsmaxbX2y2dui5K?videoPreview=1 Forced Vlasov-Poisson turbulencenohttps://cassyni.com/events/DAn7PzrqsmaxbX2y2dui5K?videoPreview=12024-04-18T06:00:00+00:003785.24Journal of Plasma PhysicsA theory is proposed, and confirmed by numerical simulations, of Vlasov-Poisson kinetic plasma turbulence at Debye and sub-Debye scales. This theory describes what is likely to be the “final cascade”—a universal regime to be encountered at the extreme small-scale end of any turbulent cascade in a nearly collisionless plasma. The cascaded invariant is the generalized (negative) entropy C_2, which is the quadratic Casimir invariant of the distribution function. C_2 cascades to small scales in both position and velocity space via both linear and nonlinear phase mixing, in such a way that the time scales associated with the two processes are “critically balanced” at every scale. We derive the scalings of the wavenumber spectra of C_2 and the electric field. The electric-field spectrum is sufficiently steep for the mixing to be controlled by the largest scales of the electric field, and so the C_2 cascade resembles the Batchelor cascade of a passive scalar field, albeit in the kinetic phase space. Our theory’s conclusions are corroborated by direct numerical simulations of a forced 1D-1V plasma. The phase-space cascade enables the irreversibility of particle heating to be achieved on collisionless time scales. The mean distribution function arising from this heating process is shown to be derivable from quasilinear considerations and is not a Maxwellian.https://cassyni-user-files-prod.s3.amazonaws.com/HzjxdArYW49FVoFdbaDNVc https://cassyni.com/slides/outline/Fe28dR6U54MSxTWXaKpLoF https://cassyni.com/events/Fe28dR6U54MSxTWXaKpLoF/abstract https://cassyni-user-files-prod.s3.amazonaws.com/PFqFPiAfpqZbjDe7KxXAcE https://cassyni.com/events/Fe28dR6U54MSxTWXaKpLoF?videoPreview=1 Flying focus beams as a tool to investigate strong-field physicsnohttps://cassyni.com/events/Fe28dR6U54MSxTWXaKpLoF?videoPreview=12023-09-28T06:00:00+00:002972.64Journal of Plasma PhysicsIn a flying focus beam (FFB) the velocity of the focus can be “programmed” and it is independent of the group and the phase velocity of the beam itself. Recent experiments have demonstrated a moving focus over centimeter lengths, i.e., much longer than the Rayleigh length. Scaling this technology to higher power laser pulses would allow one to employ FFBs as a tool for fundamen[1]tal high-field physics, especially to investigate effects that accumulate with the interaction length. Specifically, by considering an ultrarelativistic electron beam counterpropagating with respect to a FFB, whose focus copropagates with the electrons at the speed of light, we show that the effects of the so-called transverse formation length of radiation on the radiation itself can be enhanced as compared to the case of a conventional Gaussian beam. Analogously, radiation-reaction and vacuum-polarization effects can be rendered measurable at much lower intensities than conventionally required in a similar setup. Finally, we show how FF beams with angular momentum can be an efficient tool to transport ultrarelativistic electron beams over macroscopic distances without significantly spreading on the transverse plane.https://cassyni-user-files-prod.s3.amazonaws.com/PFqFPiAfpqZbjDe7KxXAcE https://cassyni.com/slides/outline/YS6JKHcCPz7HTZnNhjhQwf https://cassyni.com/events/YS6JKHcCPz7HTZnNhjhQwf/abstract https://cassyni-user-files-prod.s3.amazonaws.com/7L9FE7ZihDnkBTn79YjwCA https://cassyni.com/events/YS6JKHcCPz7HTZnNhjhQwf?videoPreview=1 Quantiles Under Ambiguity and Risk Sharingnohttps://cassyni.com/events/YS6JKHcCPz7HTZnNhjhQwf?videoPreview=12025-07-06T13:00:00+00:001165.04Risk SciencesChoquet capacities and integrals are central concepts in decision making under ambiguity or model uncertainty, pioneered by Schmeidler. Motivated by risk optimization problems for quantiles under ambiguity, we study the subclass of Choquet integrals, called Choquet quantiles, which generalizes the usual (probabilistic) quantiles, also known as Value-at-Risk in finance, from probabilities to capacities. Choquet quantiles share many features with probabilistic quantiles, in terms of axiomatic representation, optimization formulas, and risk sharing. We characterize Choquet quantiles via only one axiom, called ordinality. We prove that the inf-convolution of Choquet quantiles is again a Choquet quantile, leading to explicit optimal allocations in risk sharing problems for quantile agents under ambiguity. A new class of risk measures, Choquet Expected Shortfall, is introduced, which enjoys most properties of the coherent risk measure Expected Shortfall. Our theory is complemented by optimization algorithms, numerical examples, and a stylized illustration with financial data. [***Risk Sciences***](https://www.keaipublishing.com/en/journals/risk-sciences/) aims to foster diverse, multidisciplinary insights in risk sciences, bridging theory and practice through a series of academic activities. This speech record is an excerpt from Dr. Liu's keynote speech for the [Risk Sciences Colloquium – 2025 International Workshop on Risk Sharing (IWRS)](https://www.keaipublishing.com/en/journals/risk-sciences/event/2025-international-workshop-on-risk-sharing-iwrs/) , which was held on July 6-7, 2025, in Beijing, China. This video is categorized under ***General Theory***.https://cassyni-user-files-prod.s3.amazonaws.com/7L9FE7ZihDnkBTn79YjwCA https://cassyni.com/events/R2NEd2uKp7omhXbU9a5nVb/seminar/qa https://cassyni.com/slides/outline/R2NEd2uKp7omhXbU9a5nVb https://cassyni.com/events/R2NEd2uKp7omhXbU9a5nVb/abstract https://cassyni-user-files-prod.s3.amazonaws.com/9xvscRDwfQFjiA3fQtcWqc https://cassyni.com/slides/outline/TVcFrT8x1QaG4U52hFzRDX https://cassyni.com/events/TVcFrT8x1QaG4U52hFzRDX/abstract https://cassyni-user-files-prod.s3.amazonaws.com/6tYY7Ly1jzBvhVFa7xwrpv https://cassyni.com/events/TVcFrT8x1QaG4U52hFzRDX?videoPreview=1 Insuring our uncertain futurenohttps://cassyni.com/events/TVcFrT8x1QaG4U52hFzRDX?videoPreview=12022-09-27T06:00:00+00:003850.04Part of the nonprofit Annual Reviews organizationIs the disaster insurance industry hurtling toward a climate crisis? Learn how we can shore up programs that buffer the financial devastation that follows floods, fires and hurricanes — and help individuals and communities strengthen their climate resilience. https://cassyni-user-files-prod.s3.amazonaws.com/6tYY7Ly1jzBvhVFa7xwrpv https://cassyni.com/slides/outline/2oC3YGni4WtJu1nJB3QKXs https://cassyni.com/events/2oC3YGni4WtJu1nJB3QKXs/abstract https://cassyni-user-files-prod.s3.amazonaws.com/UQB5TBtYNoWcHb4iY9sJyU https://cassyni.com/events/2oC3YGni4WtJu1nJB3QKXs?videoPreview=1 Saffman-Taylor Instabilities in Shear-Thinning Fluidsnohttps://cassyni.com/events/2oC3YGni4WtJu1nJB3QKXs?videoPreview=12025-06-12T06:00:00+00:001754.12Leeds Institute for Fluid DynamicsIn this talk, we consider a simple mathematical model of the radial injection of a shear-thinning fluid, initially occupying a circular region of some initial injection radius, which displaces a viscous Newtonian fluid within a Hele-Shaw cell. For Newtonian fluids, Saffman-Taylor instabilities are known to develop when the displacing fluid is less viscous than the displaced fluid. However, when the displacing fluid is shear-thinning, its viscosity depends on radial distance from the source. Using a linear stability analysis, we show that there exists a critical radius where for injection radii larger than this critical value, the flow remains stable. In addition, we derive a series of critical radii for each mode corresponding to a sinusoidal perturbation of the fluid-fluid interface. The theoretical results are compared to a set of Hele-Shaw laboratory experiments in which a shear-thinning fluid called Xanthan gum is injected radially into a small gap between two plates, displacing a viscous Newtonian silicone oil. This comparison shows significant discrepancies between theory and experiment, and we delve into this problem further to locate the missing physics. https://cassyni-user-files-prod.s3.amazonaws.com/UQB5TBtYNoWcHb4iY9sJyU https://cassyni.com/slides/outline/3HqeaxSEVySMtnKBmUh7oB https://cassyni.com/events/3HqeaxSEVySMtnKBmUh7oB/abstract https://cassyni-user-files-prod.s3.amazonaws.com/MsK1ZVxt2sFqZ8D89gSeQW https://cassyni.com/events/3HqeaxSEVySMtnKBmUh7oB?videoPreview=1 Oblique laminar-turbulent interfaces in plane channel flowsnohttps://cassyni.com/events/3HqeaxSEVySMtnKBmUh7oB?videoPreview=12022-04-28T06:00:00+00:003016.52Leeds Institute for Fluid DynamicsThe transition to turbulence in plane channel flows at low Reynolds numbers is investigated through numerical simulations and theoretical analysis, focusing on the simplest turbulent states near onset. Classical linear stability theory predicts laminar flow stability up to Reynolds numbers around 5,772, with instabilities characterized by spanwise vortices; however, turbulence is observed experimentally and numerically at much lower Reynolds numbers, indicating subcritical finite-amplitude transitions disconnected from linear instabilities. Direct numerical simulations reveal laminar-turbulent coexistence organized into oblique banded patterns with angles between 20° and 45°, accompanied by large-scale secondary flows at the laminar-turbulent interfaces. These patterns emerge below a friction Reynolds number (Re_τ) of approximately 95, marking the onset of modulation in turbulence intensity. A novel approach linearizes perturbations around the fully turbulent state rather than the laminar flow, yielding a dispersion relation that identifies the critical Reynolds number and characteristic wavelength of the instability. The observed instability is hypothesized to be analogous to a Turing-type mechanism, where laminar flow acts as an inhibitor diffusing faster than the turbulent activator, consistent with the critical Re_τ values found. Additional empirical criteria, such as the ratio of channel half-gap to viscous length scale and the friction factor (C_f ≈ 0.01), correlate with the onset of intermittent turbulence. Below Re_τ ≈ 50, turbulence becomes sparse and transient, possibly governed by directed percolation dynamics. The study uncovers exact localized solutions of the Navier-Stokes equations as precursors to turbulent patterns, highlighting open questions regarding universality across shear flows and the applicability of simple predictive rules.https://cassyni-user-files-prod.s3.amazonaws.com/MsK1ZVxt2sFqZ8D89gSeQW https://cassyni.com/slides/outline/ACv7EXVaePC9PbJm8vG3ws https://cassyni.com/events/ACv7EXVaePC9PbJm8vG3ws/abstract https://cassyni-user-files-prod.s3.amazonaws.com/NR9tBUndTnipyXQVHtGohG https://cassyni.com/events/ACv7EXVaePC9PbJm8vG3ws?videoPreview=1 Structural Design Codes with AI: From Safety Margins to Smart Designnohttps://cassyni.com/events/ACv7EXVaePC9PbJm8vG3ws?videoPreview=12025-09-16T07:00:00+00:003926.72ArtIStE - Artificial Intelligence in Structural EngineeringThis presentation explores how Artificial Intelligence can transform traditional structural design codes, such as the Eurocodes, by enhancing accuracy, reducing conservative safety factors, and enabling optimized designs. AI, especially physics-informed models, offers the ability to predict and distinct complex failure mechanisms and their combinations that elude simplified mechanical models—particularly in thin-walled steel structures and steel-concrete composite systems where multiple or interconnected failure modes may occur. These insights are vital as the industry shifts toward modern methods of construction, such as modular systems, where adaptability and predictive intelligence are key. AI agents and assistants can act as design co-pilots, streamlining code interpretation and adaptation for projectspecific optimizations. Computer vision and pattern recognition are employed to assess the structural components— paving the way for a circular economy in construction. Moreover, AI enhances predictive modelling accuracy and provides real-time assistance in delivering higher quality, code-compliant structures that reflect the real-world behavior of materials and connections more faithfully.https://cassyni-user-files-prod.s3.amazonaws.com/NR9tBUndTnipyXQVHtGohG https://cassyni.com/events/L5upGpwxpuCCPb1Bw3xriR/abstract https://cassyni-user-files-prod.s3.amazonaws.com/6ePQEEJiqD1uwjJvYMQnL6 https://cassyni.com/slides/outline/WTXWFBXz3Wpcv6JKx9ukPw https://cassyni.com/events/WTXWFBXz3Wpcv6JKx9ukPw/abstract https://cassyni-user-files-prod.s3.amazonaws.com/M3gpkfPPsVw5HANhVBpuwU https://cassyni.com/events/WTXWFBXz3Wpcv6JKx9ukPw?videoPreview=1 Transitional regimes in incompressible wall-bounded shear flowsnohttps://cassyni.com/events/WTXWFBXz3Wpcv6JKx9ukPw?videoPreview=12026-05-13T13:00:00+00:003562.04Department of AeronauticsWall-bounded flows are known to support turbulence even in regimes where the laminar flow is linearly stable. This can lead, at low enough Reynolds numbers, to a spatio-temporal competition between the two types of dynamics. Many questions about these mixed regimes stay open as of today. In particular, we would like to understand the mechanisms leading from homogeneous shear turbulence to regular laminar/turbulent patterns. In this talk we will review the latest developments on the topic, involving large-scale simulations, stability theory in a turbulent context, and phenomenological modelling attempts. https://cassyni-user-files-prod.s3.amazonaws.com/M3gpkfPPsVw5HANhVBpuwU https://cassyni.com/events/RX3TnM4jewHbWzaywgCkfo/seminar/qa https://cassyni.com/slides/outline/RX3TnM4jewHbWzaywgCkfo https://cassyni.com/events/RX3TnM4jewHbWzaywgCkfo/abstract https://cassyni-user-files-prod.s3.amazonaws.com/D5EtpjKdwrQyUQGbfFFQxW https://cassyni.com/events/RX3TnM4jewHbWzaywgCkfo?videoPreview=1 Review on high energy string scattering amplitudes and symmetries of string theorynohttps://cassyni.com/events/RX3TnM4jewHbWzaywgCkfo?videoPreview=12025-12-08T12:00:00+00:003638.0Physics ReportsWe review high energy symmetries of string theory at both the Öxed angle or Gross regime (GR) and the Öxed momentum transfer or Regge regime (RR). We calculated in details high energy string scattering amplitudes (SSA) at arbitrary mass levels for both regimes. We discovered inÖnite linear relations among Öxed angle hard SSA (HSSA) conjectured by Gross in 1988 from decoupling of high energy zero-norm states (ZNS), and inÖnite recurrence relations among Regge SSA (RSSA) from Kummer function U and Appell function F1. However, the linear relations we obtained in the GR corrected [27ñ32] the saddle point calculations of Gross, Gross and Mende and Gross and Manes [1ñ5]. Our results were consistent with the decoupling of high energy ZNS or unitarity of the theory while those of them were not. In addition, for the case of closed HSSA, our results [36] di§er from theirs by an oscillating prefactor which was crucial to recover the KLT relation valid for all energies. One important application of the inÖnite linear relations in the GR was the calculation of the ratio between s-t and t-u channel HSSA in 2006 [36]. The same ratio valid for all energies was later obtained in 2009 [38] which was the stringy extension of the BCJ relation of gauge Öeld theory discovered in 2008 [41]. In the GR/RR, all high energy SSA can be solved by these linear/recurrence relations so that all GR/RR SSA can be expressed in terms of one single GR/RR SSA. In addition, we found an interesting link between HSSA and RSSA, and discovered that at each mass level the ratios among HSSA can be extracted from RSSA. This result enables us to argue that the known SL(5,C) dynamical symmetry of the Appell function F1 is crucial to probe high energy spacetime symmetry of string theory. Finally, we brieáy review recent discovery of the exact n-point Lauricella SSA (LSSA) valid for all energies and their associated SL(K+3,C) symmetry. The stringy scaling behaviors of both n-point HSSA and RSSA which are generalization of 4-point inÖnite linear relations are also briefly discussedhttps://cassyni-user-files-prod.s3.amazonaws.com/D5EtpjKdwrQyUQGbfFFQxW https://cassyni.com/slides/outline/3nWskGbeLnvBiFJhZap5yP https://cassyni.com/events/3nWskGbeLnvBiFJhZap5yP/abstract https://cassyni-user-files-prod.s3.amazonaws.com/LrULKD6wPWr9GmM1mxz9WN https://cassyni.com/events/3nWskGbeLnvBiFJhZap5yP?videoPreview=1 Publishing and Academia: A Transforming Relationshipnohttps://cassyni.com/events/3nWskGbeLnvBiFJhZap5yP?videoPreview=12020-09-23T08:00:00+00:003544.96Palgrave MacmillanThe evolving relationship between academic publishing and academia remains critical amid ongoing transformations driven by globalization, technological advances, and recent societal challenges. The establishment of Palgrave Macmillan in 2000 exemplifies a strategic response to the need for a unified global academic publishing identity, overcoming historical limitations such as territorial naming rights and fragmented markets. This rebranding combined organizational restructuring with a comprehensive brand strategy, reinforcing the imprint’s intellectual heritage and expanding its international reach. Empirical reflections on publishing underscore the enduring significance of scholarly books, particularly in the humanities, where monographs continue to hold high esteem in research assessment frameworks and provide sustained, in-depth analysis beyond shorter academic outputs. Publishing supports academic impact by underpinning engagement with policymakers, practitioners, and broader publics, as demonstrated through case studies in media and children’s screen content. However, contemporary challenges persist, including the shift to electronic resources, affordability and access disparities, diversity in authorship, and increasing demands on academics’ time for peer review and editorial work. The COVID-19 pandemic has accelerated changes in research methodologies and teaching practices, emphasizing digital delivery and electronic reading lists while highlighting the need for inclusive and adaptable publishing models. Despite these pressures, the synergy between publishers and academics is expected to maintain the availability and relevance of scholarly books across platforms, ensuring their continued role in knowledge dissemination and academic careers.https://cassyni-user-files-prod.s3.amazonaws.com/LrULKD6wPWr9GmM1mxz9WN https://cassyni.com/events/G8iyuMmmKEm3bvYWXwNp7X/seminar/qa https://cassyni.com/slides/outline/G8iyuMmmKEm3bvYWXwNp7X https://cassyni.com/events/G8iyuMmmKEm3bvYWXwNp7X/abstract https://cassyni-user-files-prod.s3.amazonaws.com/LJLH3CHtNQFfUw7ob4gQiJ https://cassyni.com/events/G8iyuMmmKEm3bvYWXwNp7X?videoPreview=1 Finding new kinetic physics and developing fluid models for it using ML-augmented kinetic and fluid simulationsnohttps://cassyni.com/events/G8iyuMmmKEm3bvYWXwNp7X?videoPreview=12025-12-18T16:00:00+00:003040.0Journal of Plasma PhysicsThe training of neural networks, the workhorses of modern ML, relies on a key, enabling technology called Automatic Differentiation (AD). This talk will show how to leverage AD with physical, hpc-scale simulations in order to solve typical plasma physics research questions. We will motivate and discuss the integration of AD into a 1D1V Vlasov-Fokker-Planck code in order to make it "differentiable". This enables the usage of gradient based techniques to solve inverse/optimization problems. It also puts mathematical modeling on an equal footing with neural networks and enables seamless mixing and matching between the two. We discuss two examples of this. First, we turn the search for new physics from a parameter scan into an inverse problem and find a novel, nonlinear kinetic effect. Next, we model these dynamics using a fluid code by adding a machine-learned closure that is trained by minimizing the error between the ML+fluid and kinetic simulations. The training is performed on a set of single-wavelength simulations and produces stable dynamics that scale to 100x larger geometries in time and space. https://cassyni-user-files-prod.s3.amazonaws.com/LJLH3CHtNQFfUw7ob4gQiJ https://cassyni.com/slides/outline/AhbLPqezVCfyD4JGw2P285 https://cassyni.com/events/AhbLPqezVCfyD4JGw2P285/abstract https://cassyni-user-files-prod.s3.amazonaws.com/2B8VAAvBmYcGdPh5qFft3p https://cassyni.com/events/AhbLPqezVCfyD4JGw2P285?videoPreview=1 CKD: Pregnancy in Renal Diseasenohttps://cassyni.com/events/AhbLPqezVCfyD4JGw2P285?videoPreview=12020-08-26T08:00:00+00:009819.2Imperial College Renal and Transplant CentreChronic kidney disease (CKD) significantly impacts pregnancy outcomes, with risks escalating alongside disease severity. Analysis of a UK multicenter cohort of 220 women with advanced CKD (stages 3–5) confirmed increased rates of preterm delivery, fetal growth restriction, and maternal renal function decline. Key predictors of adverse outcomes included chronic hypertension, proteinuria, and insufficient early pregnancy serum creatinine reduction, surpassing CKD stage alone in prognostic value. Pregnancy induces an irreversible stepwise decline in renal function, accelerating progression by 1.7 to 4.9 years depending on baseline CKD stage, necessitating informed counseling regarding future renal replacement therapy. Fertility is markedly reduced in end-stage renal disease (ESRD), but transplantation and intensified dialysis regimens improve conception rates. Dialysis during pregnancy requires multidisciplinary management, with evidence supporting initiation at midweek pre-dialysis urea levels of 17–20 mmol/L and intensive regimens (up to 36 hours/week) correlating with improved fetal survival and birthweight. Anemia, electrolyte balance, blood pressure control, and anticoagulation require careful adjustment. Peritoneal dialysis is generally discouraged during pregnancy due to mechanical and clinical challenges. Contraception remains underutilized in women with CKD and transplant recipients despite high risks of unplanned pregnancy and teratogenic medication exposure; long-acting reversible contraceptives and progesterone-only methods are preferred. In lupus nephritis, active disease, hypertension, and lupus anticoagulant positivity increase adverse pregnancy risks. Pre-pregnancy counseling emphasizing disease quiescence, medication optimization (e.g., cessation of mycophenolate mofetil and ACE inhibitors), and fertility assessment is critical. Renal biopsy in pregnancy is reserved for cases where histological diagnosis will alter management, balancing procedural risks. Collaborative specialist care and vigilant postpartum follow-up are essential to optimize maternal and fetal outcomes and long-term health.https://cassyni-user-files-prod.s3.amazonaws.com/2B8VAAvBmYcGdPh5qFft3p https://cassyni.com/events/XSrLTBLvKnrVjKpjLhKWqT/seminar/qa https://cassyni.com/slides/outline/XSrLTBLvKnrVjKpjLhKWqT https://cassyni.com/events/XSrLTBLvKnrVjKpjLhKWqT/abstract https://cassyni-user-files-prod.s3.amazonaws.com/61m1VLKo1GgNGzdRniCCMc https://cassyni.com/events/XSrLTBLvKnrVjKpjLhKWqT?videoPreview=1 Bridging the Gap to Industry: Continuous CO₂ Electroreduction from Lab-Scale Cells to Electrolyzer Systemsnohttps://cassyni.com/events/XSrLTBLvKnrVjKpjLhKWqT?videoPreview=12026-01-29T11:00:00+00:003067.08ElsevierCarbon capture, utilization, and storage (CCUS) strategies are increasingly recognized as effective means to achieve carbon neutrality, while simultaneously enabling the conversion of CO₂ into value-added products. Among these approaches, electrochemical CO₂ reduction (CO₂RR) stands out due to its operation under mild temperature and pressure conditions and its potential to store intermittent renewable energy—such as solar or wind—in the form of chemical products like formic acid and formate [1]. The Development of Chemical Processes and Pollution Control (DePRO) research group at the University of Cantabria (Spain) has been actively involved in advancing continuous CO₂ electroreduction to formate. Over the past years, the group has systematically investigated a wide range of cathodic and anodic electrocatalysts, as well as various electrode configurations, to optimize the performance and stability of the system [2–5]. This communication presents recent advances and persistent challenges in the development of efficient continuous-flow CO₂ electroreduction systems, with a particular focus on the influence of the cathodic electrocatalytic area, an aspect that has been scarcely explored to date. All experiments were conducted under a standardized setup and operating conditions, while varying key parameters such as cathodic electrocatalysts—including Sn- [2], Bi- [3], and Sb-based materials [4]—and electrode architectures, such as planar electrodes, particulate electrodes (PE), gas diffusion electrodes (GDEs), catalyst-coated membrane electrodes (CCMEs), and membrane electrode assemblies (MEAs), operating in the gaseous-phase [6], using a geometric area of 10 cm2. On the anodic side, different materials have been explored, including DSA/O₂ and Ni-based electrodes [5], with electrolysis typically coupled to the oxygen evolution reaction (OER). Both cation exchange membranes (CEM, e.g., Nafion) and anion exchange membranes (AEM, e.g., Sustainion) were tested, allowing for comparative performance analysis and identification of optimal cell configurations. The promising results obtained by the research group have enabled the scale-up of the CO₂ electroreduction technology from a lab-scale reactor (10 cm²) to semi-industrial pilot plant configurations (100 and 1000 cm²) within the framework of various projects aimed at constructing and testing a CO₂ electrolyzer under real industrial conditions, including textile and cement plants. During the initial scale-up to a geometric area of 100 cm2, optimal performance was achieved at a current density of 200 mA·cm⁻² and a water feed rate of 15 g·h⁻¹, resulting in a formate concentration of 760 g·L⁻¹, a Faradaic efficiency of 67%, a production rate of 7 mmol·m⁻²·s⁻¹, and an energy consumption of 507 kWh·kmol⁻¹. When compared with the 10 cm² lab-scale reactor, the scaled-up system demonstrated enhanced CO₂ conversion and higher product formation rates, thereby validating the advantages of optimized flow field design and the overall scale-up strategy. Although a moderate decrease in energy efficiency was observed—mainly due to increased ohmic losses—these findings support the technical viability of gas-phase CO₂ electrolysis for formate production at larger scales. Further improvements in cell design, materials selection, and energy management are necessary to move closer to industrial implementation. Nonetheless, these developments represent a significant step forward in the advancement and potential application of CO₂ electroreduction technologies. Acknowledgements The authors fully acknowledge the financial support received from the Spanish State Research Agency (AEI) through the projects PID2022- 138491OB-C31 (MICIU/AEI /10.13039/ 501100011033 and FEDER, UE), TED2021- 129810B-C21, and PLEC2022-009398 (MCIN/AEI/10.13039/501100011033 and Union Europea Next Generation EU/PRTR). The present work is related to CAPTUS Project. This project has received funding from the European Union’s Horizon Europe research and innovation programme under grant agreement No 101118265. Jose Antonio Abarca gratefully acknowledges the predoctoral research grant (FPI) PRE2021-097200. References [1] Fernández-Caso, K.; Diaz-Sainz, G.; Alvarez-Guerra, M.; Irabien, A. Electroreduction of CO2: Advances in the Continuous Production of Formic Acid and Formate. ACS Energy Lett. 2023, 8, 4, 1992-2024. https://doi.org/10.1021/acsenergylett.3c00489 [2] Del Castillo, A.; Alvarez-Guerra, M.; Solla-Gullón, J.; Sáez, A.; Montiel, V.; Irabien, A. Sn nanoparticles on gas diffusion electrodes: Synthesis, characterization and use for continuous CO2 electroreduction to formate. J. CO2 Util. 2017, 18, 222-228. https://doi.org/10.1016/j.jcou.2017.01.021 [3] Diaz-Sainz, G.; Alvarez-Guerra, M.; Solla-Gullón, J.; García-Cruz, L.; Montiel, V.; Irabien, A. CO2 electroreduction to formate: Continuous single-pass operation in a filter-press reactor at high current densities using Bi gas diffusion electrodes. J. CO2 Util. 2019, 34, 12-19. https://doi.org/10.1016/j.jcou.2019.05.035 [4] Diaz-Sainz, G.; Fernández-Caso, K.; Avila-Bolívar, B.; Montiel, V.; Solla-Gullón, J.; Alvarez-Guerra, M.; Irabien, A. Advances in the development of innovative Bi-Sn-Sb-based Gas Diffusion Electrodes for continuous CO2 electroreduction to formate. J. CO2 Util. 2025, 95, 103070. https://doi.org/10.1016/j.jcou.2025.103070 [5] Diaz-Sainz, G.; Fernández-Caso, K.; Lagarteira, T.; Delgado, S.; Alvarez-Guerra, M.; Mendes, A.; Irabien, A. Coupling continuous CO2 electroreduction to formate with efficient Ni-based anodes. J. Environ. Chem. Eng. 2023, 11, 109171. https://doi.org/10.1016/j.jece.2022.109171 [6] Diaz-Sainz, G.; Alvarez-Guerra, M.; Avila-Bolívar, B.; Solla-Gullón, J.; Montiel, V.; Irabien, A. Improving trade-offs in the figures of merit of gas-phase single-pass continuous CO2 electrocatalytic reduction to formate. Chem. Eng. J. 2021, 405, 126965. https://doi.org/10.1016/j.cej.2020.126965 https://cassyni-user-files-prod.s3.amazonaws.com/61m1VLKo1GgNGzdRniCCMc https://cassyni.com/events/Lab3S97Nfig2D3zhjA5ptd/abstract https://cassyni-user-files-prod.s3.amazonaws.com/JnpEup8eKGxFhyeWDcigQN https://cassyni.com/slides/outline/UycKDm7J8W61NPMAo1Qt7X https://cassyni.com/events/UycKDm7J8W61NPMAo1Qt7X/abstract https://cassyni-user-files-prod.s3.amazonaws.com/N1sPiQLmmtp2scrFDMwAKQ https://cassyni.com/events/UycKDm7J8W61NPMAo1Qt7X?videoPreview=1 Differentiable PDE Solvers - A Shift of Paradigms for Numerical Simulationsnohttps://cassyni.com/events/UycKDm7J8W61NPMAo1Qt7X?videoPreview=12026-01-15T19:30:00+00:004419.84AI Institute in Dynamic SystemsIn this talk, I will talk about lessons from the area of AI / deep learning for physics simulations with numerical solvers. A key focus is the utilization of solvers that are capable of providing gradient information, i.e. "differentiable simulations". These solvers seamlessly integrate with deep learning algorithms, presenting numerous advantages in arising from AI-based components in solvers, particularly in the context of flow simulations. However, the availability of gradient computation is not ubiquitous in many existing simulation environments. Avenues for computing them will be discussed, as well as fallbacks if they're not available (yet). I will show how to leverage differentiable solvers in varied applications such as closure modeling for Navier-Stokes, accelerated solving and inverse problems.https://cassyni-user-files-prod.s3.amazonaws.com/N1sPiQLmmtp2scrFDMwAKQ https://cassyni.com/events/TzK78PpFFayrhdXAh2wZJd/seminar/qa https://cassyni.com/slides/outline/TzK78PpFFayrhdXAh2wZJd https://cassyni.com/events/TzK78PpFFayrhdXAh2wZJd/abstract https://cassyni-user-files-prod.s3.amazonaws.com/HnNpWmkUEGf6vF3xWCwE8v https://cassyni.com/events/TzK78PpFFayrhdXAh2wZJd?videoPreview=1 Turbulence Modelling: Needs, Obstacles, and Opportunitiesnohttps://cassyni.com/events/TzK78PpFFayrhdXAh2wZJd?videoPreview=12026-02-17T16:00:00+00:003105.96Department of AeronauticsThe persistent need to assess and improve RANS models, in this era of Turbulence-Resolving Simulations, is justified. The tendency to stagnation is partly explained by factors such as: the sheer scope of the project, given minimal tools and all the constraints of CFD solvers; the disappointing contribution of DNS; a newly argued Structural Limitation for "classical" RANS models; the lack of maturity in AI work; and the surprising prevalence of what are to the author obvious Fallacies. The user-adjustable models GEKO and SG26 are discussed. On a more positive note, the integration with experiment and DNS is now stronger thanks to modern flow-field measurements and creative quantities extracted from DNS. https://cassyni-user-files-prod.s3.amazonaws.com/HnNpWmkUEGf6vF3xWCwE8v https://cassyni.com/events/P3TyBNeUdKQ1zG4ygXHeu3/seminar/qa https://cassyni.com/slides/outline/P3TyBNeUdKQ1zG4ygXHeu3 https://cassyni.com/events/P3TyBNeUdKQ1zG4ygXHeu3/abstract https://cassyni-user-files-prod.s3.amazonaws.com/JeArhF5CoDD2uYWJtqq2dt https://cassyni.com/events/P3TyBNeUdKQ1zG4ygXHeu3?videoPreview=1 Thieme Cheminar: Strain-Release Chemistrynohttps://cassyni.com/events/P3TyBNeUdKQ1zG4ygXHeu3?videoPreview=12026-02-24T10:00:00+00:007959.48Thieme GroupJoin us for the Thieme Cheminar “Strain-Release Chemistry”! Tuesday, February 24, 2026, 11:00 AM (CET) This special online event, brought to you by SYNTHESIS Journal, highlights the versatile role and groundbreaking impact of strain‑release chemistry in modern organic synthesis. Strained molecules offer unique reactivity and open new pathways for innovative transformations. The program will feature outstanding talks from leading researchers in the field: 🔹 Dr. Durga Prasad Hari (Indian Institute of Science Bangalore, India) 🔹 Prof. Jérôme Waser (École Polytechnique Fédérale de Lausanne, Switzerland) 🔹 Prof. Peter Wipf (University of Pittsburgh, USA) The session will be chaired by Prof. Akkattu T. Biju, Associate Editor of SYNTHESIS Journal. Do not miss this unique opportunity to explore cutting-edge advances in strain‑release chemistry and engage with some of the leading voices defining tomorrow’s organic chemistry! https://cassyni-user-files-prod.s3.amazonaws.com/JeArhF5CoDD2uYWJtqq2dt https://cassyni.com/events/HcLKfrXhoHJwbPpk5cHrub/abstract https://cassyni-user-files-prod.s3.amazonaws.com/8gkietSMottV6R74CEisbC https://cassyni.com/slides/outline/M4uB7GaGGr7MSnavvwVzMK https://cassyni.com/events/M4uB7GaGGr7MSnavvwVzMK/abstract https://cassyni-user-files-prod.s3.amazonaws.com/41SGPmW8hvrDjvryoeFpQE https://cassyni.com/events/M4uB7GaGGr7MSnavvwVzMK?videoPreview=1 Introduction to the 28th international Biometals Webinars, Effluxosomes: A new layer of spatial control in bacterial metal homeostasis, When did siderophores arise and what does it say about their primordial role?nohttps://cassyni.com/events/M4uB7GaGGr7MSnavvwVzMK?videoPreview=12026-07-07T13:00:00+00:004762.68BioMetalsThe 28th International Biometals Webinars featured two distinct but related studies on metal homeostasis. The first explored a novel layer of spatial control, termed "effluxosomes," in bacterial metal homeostasis within *Mycobacterium tuberculosis*. P1B-type ATPases (CtpC, CtpG, CtpV), vital for the efflux of heavy metals like zinc, cadmium, and copper, operate in conjunction with small chaperone-like proteins (PacL1, PacL2, PacL3). These PacL proteins are critical for ATPase stability and metal resistance, forming mobile clusters averaging 10-13 spots per cell in the bacterial plasma membrane. These dynamic effluxosomes, stabilized by a specific JGXXT motif, also associate with diverse stress-response proteins, suggesting broader physiological roles beyond metal detoxification. The second study investigated the evolutionary origin of siderophores, crucial small molecules for iron acquisition. Phylogenomic analysis of siderophore synthesis and processing enzymes on a calibrated tree of life revealed that siderophore synthases emerged between 4.5 and 3.5 billion years ago, predating oxygenic photosynthesis. However, siderophore-reducing enzymes and esterases appeared approximately 1 billion years later. This temporal disparity suggests an initial role for siderophores beyond iron scavenging. It is hypothesized that early siderophores evolved to prevent the encrustation of neutrophilic iron-oxidizing microbes by ferric minerals, a balance critical for UV protection and cellular division in the early Earth's environment.https://cassyni-user-files-prod.s3.amazonaws.com/41SGPmW8hvrDjvryoeFpQE https://cassyni.com/events/L5by1uHDPw1Cn2kvpy2fYR/seminar/qa https://cassyni.com/slides/outline/L5by1uHDPw1Cn2kvpy2fYR https://cassyni.com/events/L5by1uHDPw1Cn2kvpy2fYR/abstract https://cassyni-user-files-prod.s3.amazonaws.com/LkEHo8aBBqQSctA3HNoCxW https://cassyni.com/events/3nD2VLvtupjC6h4STVstoP/seminar/qa https://cassyni.com/slides/outline/3nD2VLvtupjC6h4STVstoP https://cassyni.com/events/3nD2VLvtupjC6h4STVstoP/abstract https://cassyni-user-files-prod.s3.amazonaws.com/NMUsUQqEULffSSymnU3mUr https://cassyni.com/events/3nD2VLvtupjC6h4STVstoP?videoPreview=1 On the lack of external response of a nonlinear optical medium in the second-harmonic generation process nohttps://cassyni.com/events/3nD2VLvtupjC6h4STVstoP?videoPreview=12026-06-09T13:00:00+00:003919.04MetaMATThis presentation concerns the scattering problem for a nonlinear medium of compact support, D, with second-harmonic generation in nonlinear optics. Such a medium, when probed with monochromatic light beams at frequency ω, generates additional waves at frequency 2ω. The response of the medium is governed by a system of two coupled semilinear partial differential equations for the electric fields at frequency ω and 2ω. We investigate whether there are situations in which the generated 2ω wave is localized inside D, that is, the nonlinear interaction of the medium with the probing wave is invisible to an outside observer. This leads to the analysis of a semilinear elliptic system formulated in D with non-standard boundary conditions. The analysis presented here sets up a mathematical framework needed to investigate a multitude of questions related to nonlinear scattering with second-harmonic generation.https://cassyni-user-files-prod.s3.amazonaws.com/NMUsUQqEULffSSymnU3mUr https://cassyni.com/events/Tz1FsU9Vpcns65Guax1N8d/seminar/qa https://cassyni.com/slides/outline/Tz1FsU9Vpcns65Guax1N8d https://cassyni.com/events/Tz1FsU9Vpcns65Guax1N8d/abstract https://cassyni-user-files-prod.s3.amazonaws.com/SE5dJZpuogABbdUvYdL8Kx https://cassyni.com/events/Tz1FsU9Vpcns65Guax1N8d?videoPreview=1 Can God be All-Good, All-Knowing, and All-Controlling? A New Solution to the Logical Problem of Evilnohttps://cassyni.com/events/Tz1FsU9Vpcns65Guax1N8d?videoPreview=12026-04-22T14:00:00+00:004587.08Logica UniversalisThe logical problem of evil challenges the coherence of classical theism by asserting an incompatibility between the existence of evil and the divine attributes of omnipotence, omniscience, and omnibenevolence. In this paper, we present a novel resolution through a formal framework. We begin by demonstrating the incompatibility between divine omnibenevolence and religious determinism, concluding that determinism must be rejected to preserve the coherence of theistic belief. We then construct a first-order theory (LdM) that formalizes the divine attributes and the classification of situations as good or evil. A set-theoretical interpretation of LdM confirms its consistency, neutralizing the logical problem of evil as traditionally framed. Extending this framework to LdM*, we introduce distinctions among God’s deliberate, desired, and permissive wills, along with a broader understanding of divine knowledge, encompassing both actual and possible states of affairs. Our expanded theory affirms the logical consistency of the God of classical theism as All-Good, All-Knowing, and All-Controlling, reconciling divine attributes with the presence of evil in the world. This approach allows us to offer a robust logical theodicy, addressing a fundamental philosophical challenge while respecting moral freedom.https://cassyni-user-files-prod.s3.amazonaws.com/SE5dJZpuogABbdUvYdL8Kx https://cassyni.com/events/oeERErgZMSXZDaPhv6EFf/seminar/qa https://cassyni.com/slides/outline/oeERErgZMSXZDaPhv6EFf https://cassyni.com/events/oeERErgZMSXZDaPhv6EFf/abstract https://cassyni-user-files-prod.s3.amazonaws.com/9v3Fu3NY5DANv1LGUZiiwQ https://cassyni.com/events/oeERErgZMSXZDaPhv6EFf?videoPreview=1 An interview with Dr. Ziad Obermeyernohttps://cassyni.com/events/oeERErgZMSXZDaPhv6EFf?videoPreview=12026-05-11T20:00:00+00:002635.04npj Digital Medicine Hear from one of the leading researchers and public voices in digital medicine. https://cassyni-user-files-prod.s3.amazonaws.com/9v3Fu3NY5DANv1LGUZiiwQ https://cassyni.com/slides/outline/FdiHNVRie6ATMCr7S5VUrR https://cassyni.com/events/FdiHNVRie6ATMCr7S5VUrR/abstract https://cassyni-user-files-prod.s3.amazonaws.com/4caLhA8st3JR5GGDEqiDDp https://cassyni.com/events/FdiHNVRie6ATMCr7S5VUrR?videoPreview=1 Comparative analysis of sporadic, IBD-associated, early-onset and late-onset colorectal cancer: a systematic review and meta-analysisnohttps://cassyni.com/events/FdiHNVRie6ATMCr7S5VUrR?videoPreview=12026-02-19T22:00:00+00:00800.4Therapeutic Advances in GastroenterologyBackground: Colorectal cancer (CRC) remains a multifaceted disease with variations in aetiology, clinical presentation and prognostic factors. Objectives: This study explores the features and outcomes of sporadic (S-CRC), inflammatory bowel disease-associated CRC (IBD-CRC), early-onset CRC (EO-CRC) and late-onset CRC (LO-CRC). Design: This is a systematic review and meta-analysis performed following the Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) Statement, comparing S-CRC versus IBD-CRC and EO-CRC versus LO-CRC. Data sources and methods: The literature search was conducted on PubMed and Embase databases. The primary endpoint was the overall 5-year survival rate of CRC. Secondary aims included the features of CRC at diagnosis. Results: Fifty studies and 6,148,851 patients with CRC were included in the analysis. Comparing S-CRC and IBD-CRC, the overall survival was higher in S-CRC (61.88 (range 41.3-78.7) vs 55.54 (51.9-80.9) months). IBD-CRC showed a minor mean age of diagnosis (63.5 (45-78) vs 69.1 ((40-78) years), a minor risk of stage IV (odd ratio (OR) 1.091; 95%CI 1.031-1.155, p = 0.003, I 2 60.24%), higher risk of mucinous tumour (OR 3.150 95%CI 2.797-3.548, p < 0.001, I 2 96.56%), emergency diagnosis (OR 1.598, 95%CI 1.509-1.693, p < 0.001, I 2 77.40%), and synchronous neoplasia (OR 1.942 95%CI 1.705-2.211, p < 0.001, I 2 0.00%). Comparing EO-CRC and LO-CRC, OS was longer in EO-CRC (79.42 (54-96) vs 77.58 (32-92) months). EO-CRC had a higher risk of being diagnosed at stage IV (OR 1.471, 95%CI 1.456-1.486, p < 0.001, I 2 97.12%), and of having mucinous tumours (OR 1.0142, 95%CI 1.015-1.070, p = 0.002, I 2 60.48%) versus LO-CRC. Comparing IBD-CRC, EO-CRC and LO-CRC, IBD-CRC had the shortest OS (61.88 months), the highest rate of mucinous cancer (13%) and emergency diagnosis (24%), whereas metastatic disease at diagnosis was more common in EO-CRC (22.6%). Conclusion: IBD-CRC was associated with a younger mean age at diagnosis, higher risk of mucinous cancers, emergency presentation, and synchronous neoplasia compared to S-CRC. EO-CRC had a higher risk of being diagnosed at stage IV and of mucinous tumours versus LO-CRC. IBD-CRC seemed to have an overall shorter survival rate and a higher prevalence of mucinous cancers, suggesting different pathways of progression and more aggressive features.https://cassyni-user-files-prod.s3.amazonaws.com/4caLhA8st3JR5GGDEqiDDp https://cassyni.com/slides/outline/NYpN8gzxBrqxzVY665zrdj https://cassyni.com/events/NYpN8gzxBrqxzVY665zrdj/abstract https://cassyni-user-files-prod.s3.amazonaws.com/RMtE2MmjhL4tgeNMDXrEKp https://cassyni.com/events/NYpN8gzxBrqxzVY665zrdj?videoPreview=1 Session 6B: Hydrogen from Bioresources and Wastenohttps://cassyni.com/events/NYpN8gzxBrqxzVY665zrdj?videoPreview=12025-10-23T07:30:00+00:007103.92Centre for Energy TechnologyThis seminar session examined hydrogen production from bioresources and waste, emphasizing its role in low-carbon energy transitions across diverse geographic contexts. The first presentation outlined Malaysia’s strategic framework for renewable hydrogen and Power-to-X (PtX) pathways, highlighting national policies such as the Hydrogen Economy and Technology Roadmap (HETR) 2023 and the National Energy Transition Roadmap (NETR). Malaysia targets 2.5 million tonnes per annum of green hydrogen by 2050, leveraging abundant solar and bioenergy resources alongside pilot projects converting organic wastes via anaerobic digestion, dark fermentation, and biomass gasification. Challenges include high capital costs, limited infrastructure, and nascent market demand. The second presentation detailed thermochemical hydrogen production via steam gasification of biomass using dual fluidized bed reactors, with experimental and techno-economic analyses demonstrating hydrogen yields of approximately 87 g/kg biomass and energy efficiencies up to 64.2% when coupled with district heating. Novel electrified sorption-enhanced gasification approaches were introduced to increase hydrogen purity and enable CO2 capture. The third presentation focused on India’s biomass-to-syngas conversion technologies for hydrogen and derivatives, emphasizing distributed-scale applications for decarbonizing steel and refining sectors. Reported hydrogen production costs approached $3.5/kg, with syngas compositions tailored for industrial use. Panel discussions underscored feedstock availability as a key scale limitation, the need for demonstration projects, and the importance of integrating hydrogen production with end-use sectors such as chemicals, steelmaking, and maritime fuels. The consensus emphasized diversified, locally adapted technologies and feedstocks, advocating for “small is beautiful” distributed systems to complement large-scale solutions, while recognizing economic and policy challenges in advancing biomass-based hydrogen within broader energy transitions.https://cassyni-user-files-prod.s3.amazonaws.com/RMtE2MmjhL4tgeNMDXrEKp https://cassyni.com/slides/outline/R24PN7EaP9cn5yMD3V9bKb https://cassyni.com/events/R24PN7EaP9cn5yMD3V9bKb/abstract https://cassyni-user-files-prod.s3.amazonaws.com/7Z9v6eJiYwwXtHaXxsPQeJ https://cassyni.com/events/R24PN7EaP9cn5yMD3V9bKb?videoPreview=1 Understanding arbuscular mycorrhizal fungi: from natural biodiversity patterns to land management and societal needs and expectationsnohttps://cassyni.com/events/R24PN7EaP9cn5yMD3V9bKb?videoPreview=12025-08-04T10:00:00+00:002106.44NoneBiodiversity patterns of arbuscular mycorrhizal (AM) fungi are increasingly well understood at local, regional and global scales, in different natural ecosystems and in response to various disturbances. The major drivers of community assembly include edaphic and climatic variables as well as host plant diversity and abundance. A major role of biomes is recognised: natural grasslands are a habitat of high biodiversity of AM fungi in various climatic zones. Farmland management constitutes a major disturbance on AM fungal diversity, yet different agricultural practices apparently preserve AM fungal diversity and functioning differently. Soil-friendly management of agricultural lands holds the potential to promote ecosystem functioning and decrease environmental load of food production. We are conducting a country-level survey of AM fungal diversity in Estonian agricultural fields. The first results demonstrate how various management practices differently impact AM fungi, and saprotrophic, and pathogenic fungi in the fields. One of the main drivers is frequency of use of plant protection products. We also conducted a survey of farmers’ opinions on soil biodiversity and related issues and learned that farmers relate to “soil”, but less so to “soil biodiversity”. On the farmers’ side there are strong expectations for research to provide solutions to new challenges, such as new pests, shifting climate such as more variable precipitation patterns etc. Therefore, we are working together with farmers to develop deeper understanding of soil biodiversity in the society, including farmers, various land managers, policy makers and general public. The basic research approaches and accumulated understanding on AM fungal diversity now allows us to develop applications such as biodiversity-considerate soil management guidelines for farmers, and contribute to fungal, environmental, ecological literacy in the society.https://cassyni-user-files-prod.s3.amazonaws.com/7Z9v6eJiYwwXtHaXxsPQeJ https://cassyni.com/slides/outline/ACcFybpqDR19n34W2qKrms https://cassyni.com/events/ACcFybpqDR19n34W2qKrms/abstract https://cassyni-user-files-prod.s3.amazonaws.com/C4KDt6VxAwK4KT7EGMD6Pp https://cassyni.com/events/ACcFybpqDR19n34W2qKrms?videoPreview=1 Closing Remarksnohttps://cassyni.com/events/ACcFybpqDR19n34W2qKrms?videoPreview=12026-02-24T16:30:00+00:00760.76Researcher to ReaderThe R2R Conference, which aims to improve research and research communication, announced a leadership transition following 11 years under its founding organizer. Ownership of the conference will be transferred to SKS Knowledge Services, a small company led by Tiberius Ignat, who has been a long-term associate of R2R. Ignat, based in Germany with a PhD in library science, brings extensive experience in libraries, publishing, and scholarly communication. His company has event management expertise and participates in EU-funded research, including Horizon 2020 and Erasmus projects, and leads a work package in the CHEUMM project, which investigates the role of libraries in managing information overload. The outgoing organizer will remain involved as an advisor to ensure a smooth transition. Initial conference operations, including timing and venue, are expected to remain consistent. Future developments will focus on making conference outcomes more perennial and facilitating asynchronous engagement across different geographies and time zones. The conference seeks to expand its role as a platform for learning in scholarly communication, research integrity, academic freedom, responsible research and innovation, and research impact. This evolution aims to further enhance research quality by bridging continents and cultures, incorporating diverse perspectives from researchers, managers, librarians, publishers, and technology companies, underpinned by principles of honesty, transparency, and analysis-driven discourse.https://cassyni-user-files-prod.s3.amazonaws.com/C4KDt6VxAwK4KT7EGMD6Pp https://cassyni.com/slides/outline/CfrHD24TQhme8yY4aXEVVo https://cassyni.com/events/CfrHD24TQhme8yY4aXEVVo/abstract https://cassyni-user-files-prod.s3.amazonaws.com/3kDShSNwuYVXBb93WFNivJ https://cassyni.com/events/CfrHD24TQhme8yY4aXEVVo?videoPreview=1 Making Access to Trusted Research Easier (Lightning Talk)nohttps://cassyni.com/events/CfrHD24TQhme8yY4aXEVVo?videoPreview=12026-02-24T13:00:00+00:00368.36Researcher to ReaderCan you trust the content you read? GetFTR are making it easier: streamlined access to verified articles, with retraction and errata flags built right into references. This lightning talk reveals how this boosts research integrity and global discoverability.https://cassyni-user-files-prod.s3.amazonaws.com/3kDShSNwuYVXBb93WFNivJ https://cassyni.com/slides/outline/PY9CLgotU8sqoj4VUdQd5F https://cassyni.com/events/PY9CLgotU8sqoj4VUdQd5F/abstract https://cassyni-user-files-prod.s3.amazonaws.com/9y4GGmdh2AN6rHNM74V75G https://cassyni.com/events/PY9CLgotU8sqoj4VUdQd5F?videoPreview=1 B3 – From Strategy to Screens: The Methodology Behind Norco College’s Vision 2030 KPI Dashboardsnohttps://cassyni.com/events/PY9CLgotU8sqoj4VUdQd5F?videoPreview=12026-04-20T10:15:00+00:003082.6Research Analytics SummitBuilding actionable data dashboards is not plug – and – play. They require clarity, negotiation, and intentional design. This presentation demystifies the development of Norco College’s Key Performance Indicator (KPI) dashboards, aligned with the college’s 2030 Strategic Plan and Governance Manual. It highlights what it takes to transform institutional goals into actionable, user – centered visuals that inform decision – making. The 45 – minute session is organized into three connected segments: Part 1 examines Norco College’s Strategic Plan and Governance Manual, the identification of core KPIs, and the alignment to Vision 2030 priorities such as equity, affordability, and student success. Part 2 explores the methodological work behind dashboard development: locking KPI definitions, clarifying denominators, coordinating across federated data systems, and establishing governance structures that support data trust and reproducibility. Part 3 focuses on Norco’s emerging dashboard development plan, the collaboration between the college and the District IR/IE Office, and early examples that balance technical feasibility with end user needs. By sharing this end – to – end process, from strategic intent to operational execution, this session offers practical insights and replicable strategies for anyone seeking to build dashboards that are visually compelling, methodologically sound, and decision ready.https://cassyni-user-files-prod.s3.amazonaws.com/9y4GGmdh2AN6rHNM74V75G https://cassyni.com/slides/outline/WTDezFsEcYddJY44r4yZDw https://cassyni.com/events/WTDezFsEcYddJY44r4yZDw/abstract https://cassyni-user-files-prod.s3.amazonaws.com/YUaRxdbJt51jZ2twchtsw4 https://cassyni.com/events/WTDezFsEcYddJY44r4yZDw?videoPreview=1 G6 – Working Smarter, Not Harder: Excel Shortcuts and Best Practicesnohttps://cassyni.com/events/WTDezFsEcYddJY44r4yZDw?videoPreview=12026-04-21T10:15:00+00:002805.52Research Analytics SummitDesigned for Excel users who are familiar with the basics, this session is designed to share time – saving shortcuts to further advance attendees’ proficiency with Excel and to review best practices in building Excel reports. We will cover two key areas. First, attendees will learn keyboard shortcuts and other tricks to speed up their workflow. These tricks will help streamline repetitive tasks and reduce clicks to free up time. Second, we will review approaches to create formulas and reports that are accurate, transparent, and easy to maintain. Techniques like locking cell references, linking to underlying data, and clearly structuring formulas are practices that supervisors and leadership appreciate because they make your work clear, reliable, and maintainable. Whether attendees are looking to make their day – to – day work more efficient or to impress leadership, these strategies will help improve both the style and substance of Excel workbooks. The examples and demonstrations will equip attendees with the skills to create polished and accurate spreadsheets efficiently.https://cassyni-user-files-prod.s3.amazonaws.com/YUaRxdbJt51jZ2twchtsw4 https://cassyni.com/slides/outline/8ih4xBQ9JQGDVnmnTyatXX https://cassyni.com/events/8ih4xBQ9JQGDVnmnTyatXX/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Ko6DAbrh4T19PfQpR5zFQA https://cassyni.com/events/8ih4xBQ9JQGDVnmnTyatXX?videoPreview=1 Voices Lost and Found: Marking 50 Years since the Decriminalisation of Homosexualitynohttps://cassyni.com/events/8ih4xBQ9JQGDVnmnTyatXX?videoPreview=12018-08-13T06:00:00+00:00950.52NoneIn 2017 we teamed up with Being Human, a national festival dedicated to demonstrating the breadth, diversity and vitality of the humanities, led by the School of Advanced Study, University of London in partnership with the Arts & Humanities Research Council and the British Academy. We hosted a lively panel discussion which examined the evolution of gay, lesbian and queer representation across history, literature and media. Our panellists delved into what it has meant to be a ‘lost’, marginalised and even criminalised voice, and examined to what degree historically marginalised voices have been ‘found’ since this momentous Act of Parliament was passed.https://cassyni-user-files-prod.s3.amazonaws.com/Ko6DAbrh4T19PfQpR5zFQA https://cassyni.com/slides/outline/7EmsvkyTPPXbx5pdJq62F7 https://cassyni.com/events/7EmsvkyTPPXbx5pdJq62F7/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Es97rrsZbjVg6WqoKZqLjp https://cassyni.com/events/7EmsvkyTPPXbx5pdJq62F7?videoPreview=1 Skills to Outcomes: Testing Equity in Atlanta’s Business Accelerator Programsnohttps://cassyni.com/events/7EmsvkyTPPXbx5pdJq62F7?videoPreview=12025-11-19T15:30:00+00:001006.4Center for Black Entrepreneurship, Spelman CollegeDespite the growth of entrepreneurship accelerators aiming to foster rapid business growth and enhance social capital, significant disparities persist within entrepreneurial ecosystems. For instance, in regions like Atlanta, where at least 24 accelerator programs operate, White firms are valued at 11 times more than Black-owned firms, and women entrepreneurs, comprising 48% of businesses, receive less than 3% of venture funding. Grounded in social capital theory, this study investigates whether race and gender significantly predict the total skills developed and outcomes achieved by entrepreneurs participating in accelerator programs. A survey validated by G Yorke et al. collected data from over 200 Georgia-based entrepreneurs, primarily within technology, retail, food and beverage, and professional services sectors. The sample included White and Black, and female and male entrepreneurs who had completed at least one accelerator program. Independent t-tests, paired t-tests, and logistic regressions were employed to analyze dependent variables such as partnerships, funding, and hiring, alongside skills developed in marketing, finance, and investor readiness. Independent variables were gender and race, controlling for education, business age, and sector. Results indicate that entrepreneurs across all accelerators more frequently achieved immediate outcomes, such as partnerships and hiring, than developed specific skills. A consistent and significant gap was identified for female entrepreneurs, who generally experienced fewer positive outcomes and acquired fewer skills, even after controlling for education, business age, and sector. While White entrepreneurs initially achieved higher outcomes and skills within their first accelerator, no statistically significant difference was observed in subsequent programs. These findings suggest that entrepreneurship accelerators, despite their design as social capital engines, may not consistently level the playing field, particularly for women entrepreneurs. The study advocates for fund managers and policymakers to implement programmatic adjustments, enhance data transparency across diverse demographics, and develop targeted equity interventions for women-owned and Black/Brown entrepreneurs. Future research aims to increase sample size and incorporate qualitative interviews to further explore underlying mechanisms.https://cassyni-user-files-prod.s3.amazonaws.com/Es97rrsZbjVg6WqoKZqLjp https://cassyni.com/events/E9rLaL2oXoHPStpCgGexPo/abstract https://cassyni.com/events/E9rLaL2oXoHPStpCgGexPo?videoPreview=1 Life Insurance and Life Settlement Marketsnohttps://cassyni.com/events/E9rLaL2oXoHPStpCgGexPo?videoPreview=12026-06-01T01:00:00+00:002070.16Risk SciencesProfessor Fang is currently working on issues related to insurance markets, particularly the interaction between the health insurance reform and the labor market, and the alternative health insurance reform proposals. He also studies the Chinese economy, particularly on issues related to political economy, population aging and social security. [Risk sciences](https://www.keaipublishing.com/en/journals/risk-sciences/) aims to foster diverse, multidisciplinary insights in risk sciences, bridging theory and practice through a series of academic activities. This speech record is an excerpt from Prof. Hanming Fang 's keynote speech for the China Conference on Insurance and Risk Management, which was held on July 9-12, 2025, in Urumqi, China. https://cassyni.com/slides/outline/Q2r3cdVBiKHSTC6USEy6PX https://cassyni.com/events/Q2r3cdVBiKHSTC6USEy6PX/abstract https://cassyni-user-files-prod.s3.amazonaws.com/44HUQVTvmyY1qZbwNDBK66 https://cassyni.com/events/Q2r3cdVBiKHSTC6USEy6PX?videoPreview=1 “Aria” Interview: A Resilient Productionnohttps://cassyni.com/events/Q2r3cdVBiKHSTC6USEy6PX?videoPreview=12021-02-11T06:00:00+00:00265.64Hong Kong Baptist UniversityAn art experience about environmental conservation that takes place at a greenhouse - how can the experience itself be energy-efficient and eco-friendly without causing damage to the plants?https://cassyni-user-files-prod.s3.amazonaws.com/44HUQVTvmyY1qZbwNDBK66 https://cassyni.com/slides/outline/JbiQ77NQtHCN4KrEqKyJQ5 https://cassyni.com/events/JbiQ77NQtHCN4KrEqKyJQ5/abstract https://cassyni-user-files-prod.s3.amazonaws.com/W2PjDi1w6tfzdTKFpXr44W https://cassyni.com/events/JbiQ77NQtHCN4KrEqKyJQ5?videoPreview=1 Talk session 6: Meshing & geometrynohttps://cassyni.com/events/JbiQ77NQtHCN4KrEqKyJQ5?videoPreview=12026-06-10T08:00:00+00:004301.88Nektar++ Development TeamThis session explored advancements in high-order meshing and fluid-structure interaction (FSI) for complex computational fluid dynamics (CFD) applications. Work on r-adaptation for boundary layers focused on dynamically modifying prism layer meshes to resolve wall-normal gradients. A variational optimizer was developed to deform prism layers to target boundary layer thicknesses (e.g., y+≈1, δ99) using a scaling factor, demonstrating improved velocity profiles and reduced oscillations for a NACA airfoil (Re_c = 10^4). For isoparametric split boundary layers, dynamic r-adaptation was integrated into solvers, comparing reprojection and single-step Arbitrary Lagrangian-Eulerian (ALE) solution transfer. Reprojection proved efficient for few adaptation cycles, while ALE was more accurate over many cycles but sensitive to large deformations. In FSI, a novel Partially-Decomposed Velocity Correction Scheme (PD-VCS) was introduced to address instabilities in two-way coupled simulations involving light structures. This method decomposes pressure into velocity-induced and acceleration-induced (added-mass) components, leveraging a pre-calculated added-mass matrix. The PD-VCS demonstrated numerical stability for fluid-structure density ratios down to zero, significantly improving upon previous schemes (which failed below ~3.5), and showed a 25% computational speed-up. Applied to a 2D hovering flapping wing, a modified ensemble variational optimizer found trajectories minimizing power while maintaining lift, revealing altered kinematics with enhanced lift efficiency. These developments contribute to more robust, efficient, and automated mesh adaptation and FSI simulations across various engineering and bio-inspired contexts.https://cassyni-user-files-prod.s3.amazonaws.com/W2PjDi1w6tfzdTKFpXr44W https://cassyni.com/events/S1SToN5HU9WCYuNhoCq2p5/abstract https://cassyni-user-files-prod.s3.amazonaws.com/XivnjebkqR9LYyKNyaVccN https://cassyni.com/slides/outline/4GusmHcCA18nkA6RR7SN7f https://cassyni.com/events/4GusmHcCA18nkA6RR7SN7f/abstract https://cassyni-user-files-prod.s3.amazonaws.com/8brsGXEjxHhwY8CmuUW5g2 https://cassyni.com/events/4GusmHcCA18nkA6RR7SN7f?videoPreview=1 Interview with Rafal Marszalek, Chief Editor of Scientific Reportsnohttps://cassyni.com/events/4GusmHcCA18nkA6RR7SN7f?videoPreview=12023-10-25T06:00:00+00:00351.96Learn more about Rafal Marszalek, Chief Editor of Scientific Reports, in this interview. Rafal's background is in analytical and biological chemistry. He did his PhD and postdoctoral research in single-cell proteomics at Imperial College London, UK. He was an editor at Genome Biology for four years before joining Scientific Reports in August 2016. Scientific Reports is an open-access journal publishing original research from across all areas of the natural sciences, psychology, medicine, and engineering.https://cassyni-user-files-prod.s3.amazonaws.com/8brsGXEjxHhwY8CmuUW5g2 https://cassyni.com/events/9i3XGoixz3EBsZgDRjgG53/seminar/qa https://cassyni.com/slides/outline/9i3XGoixz3EBsZgDRjgG53 https://cassyni.com/events/9i3XGoixz3EBsZgDRjgG53/abstract https://cassyni-user-files-prod.s3.amazonaws.com/CFypEitHK88GFTANbkG3QS https://cassyni.com/events/9i3XGoixz3EBsZgDRjgG53?videoPreview=1 From Silk Fibres to Multifunctional Biodegradable Materialsnohttps://cassyni.com/events/9i3XGoixz3EBsZgDRjgG53?videoPreview=12026-06-17T13:10:00+00:001209.28NoneSilk fibers, known for their exceptional toughness and hierarchical structure, present a challenge for traditional material processing due to their intractable nature, which prevents thermoplastic-like reshaping without degrading their properties. This study develops a novel thermomechanical method to transform natural silk fibers into monolithic materials without dissolution or the addition of a matrix, thereby preserving their inherent hierarchical structure and crystallinity. By applying heat and pressure within a specific processing window (95-240 °C), uniform unidirectional (UD) preforms were consolidated into solid, low-porosity materials, with proposed self-diffusion of amorphous regions at nanofibrillar interfaces facilitating fusion. The resulting fused silk materials exhibit record-high mechanical properties, including flexural strength up to 600 MPa and flexural modulus exceeding 20 GPa, outperforming previous silk-based composites and comparing favorably with synthetic fiber-reinforced polymers in terms of strength and fracture toughness. Furthermore, these materials demonstrate tunable biodegradability *in vitro* and *in vivo*, with degradation rates influenced by processing temperature, alongside good biocompatibility. Additional functionalities include re-healable interfaces, energy harvesting potential when integrated into triboelectric nanogenerators, and distinctive optical properties (visible transparency, strong UV absorption, terahertz-polarized light responsiveness), opening avenues for applications in structural composites, biomedicine, energy, and advanced optics.https://cassyni-user-files-prod.s3.amazonaws.com/CFypEitHK88GFTANbkG3QS https://cassyni.com/slides/outline/N4HFYXQyMqzmuicRgfBRqo https://cassyni.com/events/N4HFYXQyMqzmuicRgfBRqo/abstract https://cassyni-user-files-prod.s3.amazonaws.com/5irrmqtTGcDrQkeN6NYHwU https://cassyni.com/events/N4HFYXQyMqzmuicRgfBRqo?videoPreview=1 I4 - It Depends!: Building Data Literacy as a Shared Language for Research Analyticsnohttps://cassyni.com/events/N4HFYXQyMqzmuicRgfBRqo?videoPreview=12026-04-21T18:30:00+00:002879.24Research Analytics SummitResearch analytics professionals face a universal challenge: creating shared understanding across stakeholders who speak different “languages.” When a dean asks to “show our research excellence” or a provost wants to know if “we're competitive,” the challenge isn't technical, it's understanding what decision needs to be made and what data can appropriately inform it. This session is for anyone who translates research data into insights for stakeholders. Participants will learn about data literacy concepts applicable to research analytics, and will have an opportunity to explore the benefits of improving data literacy in their daily work in this interactive session.https://cassyni-user-files-prod.s3.amazonaws.com/5irrmqtTGcDrQkeN6NYHwU https://cassyni.com/events/5ktK1y4esjimENuwKC2f6m/seminar/qa https://cassyni.com/slides/outline/5ktK1y4esjimENuwKC2f6m https://cassyni.com/events/5ktK1y4esjimENuwKC2f6m/abstract https://cassyni-user-files-prod.s3.amazonaws.com/EaX9M5peitLTvjNd4MrFsC https://cassyni.com/events/5ktK1y4esjimENuwKC2f6m?videoPreview=1 Women in Electronics nohttps://cassyni.com/events/5ktK1y4esjimENuwKC2f6m?videoPreview=12026-09-16T14:30:00+00:007310.32Advanced Electronic Materials JournalLaunched in recognition of the International Day of Women and Girls in Science (11 February), the joint Advanced Electronic Materials / Advanced Materials Interfaces special issue Women in Emerging Organic and Hybrid Electronic Materials and Interfaces showcases cutting-edge research from women scientists at the forefront of advanced electronics. Now Advanced Electronic Materials wants to give voice to the authors , inviting the academic community to the next webinar , "Women in Electronics", next 16th September (4:30-6:30 pm,): with the intervention of 4 worldwide recognized authors - Prof. Luisa Torsi (Bari University, Italy), Prof Sahika Inal (Kaust University, Saudi Arabia), Prof Claudia Tortiglione (Institute of Applied Sciences, CNR, Italy) and Prof Laurie Calvet ( CNRS- Ecolo Polytechnique, France ), the webinar will explore key advances in bioelectronics, wearable and implantable devices, energy storage, sensing, and optoelectronics, highlighting both fundamental discoveries and application-driven innovations. By bringing together diverse perspectives from across disciplines, the session will reveal emerging trends and opportunities that are redefining the future of electronic materials and interfaces. Participants will gain a unique overview of a vibrant and rapidly evolving research landscapehttps://cassyni-user-files-prod.s3.amazonaws.com/EaX9M5peitLTvjNd4MrFsC https://cassyni.com/slides/outline/XwFLUCMU9156mEcTCDwnyj https://cassyni.com/events/XwFLUCMU9156mEcTCDwnyj/abstract https://cassyni-user-files-prod.s3.amazonaws.com/3VDnwpzyiGRPBAJ6cAxpra https://cassyni.com/events/XwFLUCMU9156mEcTCDwnyj?videoPreview=1 Dry air, hotter land: how vegetation responses amplify future warmingnohttps://cassyni.com/events/XwFLUCMU9156mEcTCDwnyj?videoPreview=12026-06-03T14:15:00+00:00664.88Temperature regulates vegetation dynamics through both thermal and hydrologic pathways. While climate change driven warming is typically assessed using air temperature (Tair), vegetation directly experiences land surface temperature (LST), which remains comparatively understudied. Key gaps persist in understanding how LST is changing and whether vegetation responses to LST amplify future warming. Here, we integrate model simulations and observations using a dual emergent constraint to quantify projected differences between LST and Tair (ΔT) by 2100. We show that LST increases are expected to outpace Tair across most global regions, implying more extreme thermal stress on vegetation than previously recognized. The largest projected increases in ΔT occur where increasing atmospheric dryness increasingly constrains vegetation function. This suggests that future warming will impose stronger limitations on plant function than currently estimated, while reduced transpiration is likely to further elevate LST. Consequently, reliance on Tair alone leads to systematic underestimation of temperature impacts on vegetation dynamics and the land carbon sink. Accurate representation of LST in Earth system models is therefore essential for improving projections of ecosystem responses and climate feedbacks.https://cassyni-user-files-prod.s3.amazonaws.com/3VDnwpzyiGRPBAJ6cAxpra https://cassyni.com/slides/outline/SW7gxgEhJxz2NNNDbJwzzH https://cassyni.com/events/SW7gxgEhJxz2NNNDbJwzzH/abstract https://cassyni-user-files-prod.s3.amazonaws.com/3jYbUApjvzhS1ewerwZ68N https://cassyni.com/events/SW7gxgEhJxz2NNNDbJwzzH?videoPreview=1 Impacts of heat on plants as seen from spacenohttps://cassyni.com/events/SW7gxgEhJxz2NNNDbJwzzH?videoPreview=12026-06-05T07:00:00+00:001700.88Satellites are measuring Earth’s terrestrial biosphere at increasingly finer spatial and temporal resolutions, and across electromagnetic spectra, providing extensive opportunities for evaluating plant responses to heat. Here, I highlight several use cases to understand regional plant response to heat:  (i) Land surface temperature can be sampled at 5km and 15-minute scales by geostationary satellites, useful for evaluating the degree to which vegetation in hot, dry ecosystems is transpiring and cooling the surrounding environment.  (ii) Commonly used satellites (i.e., MODIS, SMAP) can track differing photosynthetic and internal water content responses to extreme heat versus extreme dry events in the western U.S. in 2020-2021. (iii) Newer, higher spatial resolution satellites (<100m) can evaluate rapid responses of different plant functional types to extremes. Specifically, I demonstrate that ECOSTRESS captures reduced evaporation during hot-dry spell events across the U.S., where vast spatial variability of responses is shown with locally differing sensitivity for grass and tree species. (iv) Finally, high resolution imagery during heatwave onset will be presented showing hotter leaf temperatures for some vegetation types than others.  These insights demonstrate that satellite observations enable a scaled-up understanding of plant responses to extreme heat, especially when connected to ground measurements.https://cassyni-user-files-prod.s3.amazonaws.com/3jYbUApjvzhS1ewerwZ68N https://cassyni.com/slides/outline/2JM5hBXyoXr8CgcNfXehZw https://cassyni.com/events/2JM5hBXyoXr8CgcNfXehZw/abstract https://cassyni-user-files-prod.s3.amazonaws.com/97iAT5fvK6emf4MxQ9S1vN https://cassyni.com/events/2JM5hBXyoXr8CgcNfXehZw?videoPreview=1 Understanding cosmic-ray transport in strong magnetic turbulencenohttps://cassyni.com/events/2JM5hBXyoXr8CgcNfXehZw?videoPreview=12026-07-30T15:00:00+00:002590.92Journal of Plasma PhysicsRecently, the compatibility of conventional cosmic-ray transport theories with observational data has been questioned, sparking interest in the role of the field-line geometry of turbulent magnetic fields. While magnetic turbulence is often modelled as a superposition of random fluctuations, both plasma simulations and astrophysical observations suggest a complex and highly structured nature. To better understand cosmic-ray transport in strong magnetic turbulence characterised by intermittency and nonlinear coherent structures, we consider test-particle simulations in high-resolution magnetohydrodynamics simulations. Variations of the magnetic moment conditional on the instantaneous gyro radius and the experienced field line curvature reveal that particle trajectories consist of magnetised motion modulated by magnetic mirroring along low-curvature field line bundles, which is intermittently interrupted by unmagnetized scattering upon encountering sharply curved field lines. Based on this paradigm, we present phenomenological models for particle transport in isotropic dynamo turbulence and strong anisotropic turbulence. We further discuss the roles of small-amplitude gyro-resonant scattering and perpendicular transport in the presence of large-amplitude magnetic mirroring and curvature scattering.https://cassyni-user-files-prod.s3.amazonaws.com/97iAT5fvK6emf4MxQ9S1vN https://cassyni.com/events/4mb6vbmbzpccZd5wDDZLHs/abstract https://cassyni-user-files-prod.s3.amazonaws.com/SRP753MJmkSfyo23MpV9HG https://cassyni.com/events/CBKAcrUUagvT4CcQB6R4hs/seminar/qa https://cassyni.com/slides/outline/CBKAcrUUagvT4CcQB6R4hs https://cassyni.com/events/CBKAcrUUagvT4CcQB6R4hs/abstract https://cassyni-user-files-prod.s3.amazonaws.com/JakqorSeVQEKuo6Cx6UGZU https://cassyni.com/events/CBKAcrUUagvT4CcQB6R4hs?videoPreview=1 Navigation of reconfigurable microswimmers at low Reynolds numbersnohttps://cassyni.com/events/CBKAcrUUagvT4CcQB6R4hs?videoPreview=12026-08-05T13:00:00+00:003785.6Journal of Engineering MathematicsThe recent surge in applying artificial intelligence (AI) to fluid mechanics and navigation problems has demonstrated the tremendous potential of AI in advancing novel designs of smart microrobotics capable of navigating complex fluid environments. In this talk, we will discuss our recent research on the reinforcement learning (RL) of reconfigurable microswimmers in low Reynolds number fluids. We will discuss a set of simple models of reconfigurable microswimmers consisting of spheres with movable arms. We will introduce two reinforcement learning (RL) approaches: one for a fully discrete reconfiguration system and another for a system with continuous variables. We will showcase how RL enables these reconfigurable microswimmers to self-learn how to swim, rotate, and navigate. We will also demonstrate how these microswimmers can learn to develop run-and-tumble navigation strategies akin to biological swimmers, by utilizing information obtained from local environmental cues. These results present a promising approach toward the development of smart microrobotics with autonomous navigation capabilities. https://cassyni-user-files-prod.s3.amazonaws.com/JakqorSeVQEKuo6Cx6UGZU https://cassyni.com/slides/outline/L5k5b3reQjdqWipnDeLCvh https://cassyni.com/events/L5k5b3reQjdqWipnDeLCvh/abstract https://cassyni-user-files-prod.s3.amazonaws.com/RNft6HRhb2MixrFVUtsbqQ https://cassyni.com/events/L5k5b3reQjdqWipnDeLCvh?videoPreview=1 Parisi: Opening and presentation of SARAH Advanced School 2026nohttps://cassyni.com/events/L5k5b3reQjdqWipnDeLCvh?videoPreview=12026-09-07T12:30:00+00:001734.08Department of Structures for Engineering and ArchitectureThe SARAH Advanced School addresses critical challenges in multi-hazard safety, structural robustness, and resilience assessment of civil engineering systems such as buildings and bridges. The academic programme focuses on investigating structural behavior under extreme loading events—including blast, impact, fire, soil settlements, and hydro-hazards—at both component and system scales. Methodological approaches combine experimental testing, forensic analysis of catastrophic failures, and high-fidelity numerical simulations (such as Applied Element Method collapse simulations) with simplified probabilistic modelling and surrogate techniques to evaluate structural reliability. Special emphasis is placed on quantifying progressive collapse mechanisms, propagating uncertainties in design and assessment, and integrating structural health monitoring for urban-scale disaster risk reduction and post-earthquake recovery. Featuring contributions from international experts and collaborative research initiatives such as the FAIL-SAFE and FIRMITAS projects, the curriculum bridges advanced computational strategies with engineering practice. The school provides a comprehensive platform for researchers and practitioners to explore state-of-the-art developments in multi-hazard resilience, system-level reliability-based design, and automated computer-aided assessment tools.https://cassyni-user-files-prod.s3.amazonaws.com/RNft6HRhb2MixrFVUtsbqQ https://cassyni.com/slides/outline/WTMmZQSfdMGG3E7vEkH6cD https://cassyni.com/events/WTMmZQSfdMGG3E7vEkH6cD/abstract https://cassyni-user-files-prod.s3.amazonaws.com/VzcBvEMcz2gZwgmaqQsM2N https://cassyni.com/events/WTMmZQSfdMGG3E7vEkH6cD?videoPreview=1 CIMR Immunology Symposiumnohttps://cassyni.com/events/WTMmZQSfdMGG3E7vEkH6cD?videoPreview=12026-07-29T08:00:00+00:007217.68Advanced ScienceThe SWI/SNF chromatin remodeling complex, particularly its SMARCB1 subunit, functions as a critical tumor suppressor; its mutations are observed in approximately 20% of all cancers and are linked to neurodevelopmental disorders. Loss of SMARCB1 in mouse models causes rapid, highly penetrant tumor development, often presenting as CD8-positive mature T-cell lymphomas. To identify therapeutic vulnerabilities in SMARCB1-deficient cancers, a functional genomic CRISPR screen was conducted across over 1,000 cancer cell lines, including 17 SMARCB1-deficient rhabdoid tumor lines. This analysis identified ZMYM3 as a specific dependency in SMARCB1-deficient cells. Mechanistic studies using ChIP and CUT&RUN demonstrated that ZMYM3, a protein with 10 zinc fingers, localizes predominantly to intergenic regions and introns and interacts strongly with subunits of the repressive CoREST complex, such as LSD1. Intriguingly, despite this co-localization, ZMYM3 antagonizes CoREST-mediated silencing, thereby favoring transcriptional activation. While ZMYM3 does not directly co-localize with SWI/SNF, SWI/SNF subunits are intensely bound at the promoters of ZMYM3 target genes, suggesting a cooperative function. A model is proposed wherein, in normal cells, the SWI/SNF complex and ZMYM3 collaborate to activate gene expression, with ZMYM3 helping to restrain the CoREST complex. When SMARCB1 and SWI/SNF function are lost, ZMYM3 becomes essential to maintain residual transcription critical for cell survival. Consequently, targeting ZMYM3 in SMARCB1-deficient cells leads to transcriptional collapse and cell death, establishing ZMYM3 as a promising therapeutic target for these cancers. This approach also revealed other chromatin-related vulnerabilities, providing a robust framework for dissecting transcriptional regulation mechanisms.https://cassyni-user-files-prod.s3.amazonaws.com/VzcBvEMcz2gZwgmaqQsM2N https://cassyni.com/slides/outline/8iqBXKyaKCtrEUqdretRuo https://cassyni.com/events/8iqBXKyaKCtrEUqdretRuo/abstract https://cassyni-user-files-prod.s3.amazonaws.com/3P9YnkmaPVVZeGyGZhrPf4 https://cassyni.com/slides/outline/AhRbi4Zg537cLC7sDckNLM https://cassyni.com/events/AhRbi4Zg537cLC7sDckNLM/abstract https://cassyni-user-files-prod.s3.amazonaws.com/HXgdbQ5C43XoDEgkjBJZ6v https://cassyni.com/events/AhRbi4Zg537cLC7sDckNLM?videoPreview=1 2025 Luxton Lecture - From ambition to action: policy to deliver Australia’s net zero ambitionsnohttps://cassyni.com/events/AhRbi4Zg537cLC7sDckNLM?videoPreview=12025-09-17T08:00:00+00:005574.28Centre for Energy TechnologyAlison Reeve is the Energy and Climate Change Program Director at Grattan Institute. She has two decades of experience in climate change, clean energy policy, and technology, in the private, public, academic, and not-for-profit sectors. Alison was previously the General Manager of Project Delivery at the Australian Renewable Energy Agency and a Visiting Fellow at the Australian National University. She led development of Australia’s National Hydrogen Strategy in 2019, as well as Commonwealth policy for offshore wind, energy innovation, energy efficiency, and structural adjustment. Alison has a Bachelor of Engineering from the University of Queensland and a Masters of Public Policy with distinction from the Australian National University. https://cassyni-user-files-prod.s3.amazonaws.com/HXgdbQ5C43XoDEgkjBJZ6v https://cassyni.com/events/BC5CkkDCWVffKxekp43Abf/abstract https://cassyni-user-files-prod.s3.amazonaws.com/UVM5wJKB9oW6WowcfwbRqp https://cassyni.com/events/LasGaSGEhKwHfXNsczruyf/abstract https://cassyni-user-files-prod.s3.amazonaws.com/EonJG9WLvrQQz1BCSj24Tg https://cassyni.com/events/6kiMHJ9YQWRp2LvAiKWWEq/seminar/qa https://cassyni.com/slides/outline/6kiMHJ9YQWRp2LvAiKWWEq https://cassyni.com/events/6kiMHJ9YQWRp2LvAiKWWEq/abstract https://cassyni-user-files-prod.s3.amazonaws.com/QBHiTZ8owcZ5DhemkiqGYE https://cassyni.com/events/6kiMHJ9YQWRp2LvAiKWWEq?videoPreview=1 The Protestant Tradition of Eulerian Diagramsnohttps://cassyni.com/events/6kiMHJ9YQWRp2LvAiKWWEq?videoPreview=12026-09-09T14:00:00+00:004223.04Logica UniversalisThis lecture examines the early modern history of logic diagrams and argues that their development was shaped by confessional contexts. While logic is often viewed as a neutral and purely rational discipline, we show that logic diagrams in the and centuries were embedded in broader religious, philosophical, and institutional traditions. After clarifying the concept of logic diagrams and the specific characteristics of Eulerian representations, we identify methodological challenges in reconstructing their history and outline several external factors that influenced their use. Using two case studies—Nicolaus Reimers Ursus in the 16th century and Erhard Weigel in the 17th century—we demonstrate that Eulerian diagrams were predominantly cultivated in Protestant circles, in contrast to Byzantine and Roman Catholic diagrammatic traditions such as crescent diagrams, the square of opposition, and phoebifer axis diagrams. These competing traditions differed not only in form but also in their underlying representations of proof, particularly regarding direct versus indirect methods. The paper argues that confessional affiliation, together with philosophical convictions such as empiricism and rationalism, contributed to the selection and evaluation of diagrammatic techniques. By situating early modern logic within its cultural context, the study highlights the role of external factors in shaping representational practices in logic.https://cassyni-user-files-prod.s3.amazonaws.com/QBHiTZ8owcZ5DhemkiqGYE https://cassyni.com/events/XT8ZbUVnMQ7mBoCuEY6bvV/abstract https://cassyni-user-files-prod.s3.amazonaws.com/JxF3bNBHpVeMVKJKR9TwBt https://cassyni.com/events/GdgSCy63BfW8srvCDtGsNm/abstract https://cassyni-user-files-prod.s3.amazonaws.com/152XBuEg9JCiq9wP32nW8W https://cassyni.com/slides/outline/3JUyDSHcmGk5HtRL5QYbuf https://cassyni.com/events/3JUyDSHcmGk5HtRL5QYbuf/abstract https://cassyni-user-files-prod.s3.amazonaws.com/WHmP2fARvegnxGm9rsiyCS https://cassyni.com/events/3JUyDSHcmGk5HtRL5QYbuf?videoPreview=1 Session 2: Real-world examples in trial protocols and trial reports (for Regulators, Funders, Journal Editors and Ethics Committee Members)nohttps://cassyni.com/events/3JUyDSHcmGk5HtRL5QYbuf?videoPreview=12023-07-13T13:10:00+00:001802.2Institute for Cancer ResearchNo abstracthttps://cassyni-user-files-prod.s3.amazonaws.com/WHmP2fARvegnxGm9rsiyCS https://cassyni.com/events/DgprAAGgTGTPd7QkV7WKEV/seminar/qa https://cassyni.com/events/DgprAAGgTGTPd7QkV7WKEV/abstract https://cassyni-user-files-prod.s3.amazonaws.com/EVVTCT3BdrqpxMF9Ai8Y5L https://cassyni.com/events/DgprAAGgTGTPd7QkV7WKEV?videoPreview=1 An Updated Evaluation of Atrazine-Cancer Incidence Associations among Pesticide Applicators in the Agricultural Health Study Cohortnohttps://cassyni.com/events/DgprAAGgTGTPd7QkV7WKEV?videoPreview=12026-01-15T19:00:00+00:003051.28Center for Cancer TrainingBackground: Atrazine is a common agricultural herbicide in the United States. Few epidemiologic studies have evaluated cancer risks. Previous analyses within the Agricultural Health Study (AHS) have found some evidence of associations with cancer at some sites. Objective: We updated exposure information, incident cases, and follow-up time to assess the associations between atrazine use and cancer at specific sites in the AHS. Methods: Information about lifetime pesticide use was reported at enrollment (1993-1997) and follow-up (1999-2005). Among 53,562 pesticide applicators in North Carolina and Iowa, we identified 8,915 incident cases through cancer registry linkages through 2014 (North Carolina)/2017 (Iowa). We used Poisson regression to evaluate the association between ever/never and intensity-weighted lifetime days of atrazine use and incident cancer risk controlling for several confounders. We also evaluated lagged exposures and age-stratified risk. Results: Approximately 71.2% of applicators reported ever using atrazine, which was associated with lung cancer [ rate ratios (RR)=1.24; 95% confidence interval (CI): 1.04, 1.46]. Aggressive prostate cancer risk was increased in the highest quartile (RRQ4=1.20; 95% CI: 0.95, 1.52; p-trend=0.19), particularly among those <60 years old (RRQ4=3.04; 95% CI:1.61,5.75; p-trend<0.001; p-interaction=0.04). Among applicators <50 years of age, ever-atrazine use was associated with non-Hodgkin lymphoma (NHL) (RR=2.43; 95% CI: 1.10, 5.38; p-interaction=0.60). For soft tissue sarcoma, there was an elevated risk in the highest tertile of exposure (RRT3: 2.54; 95% CI: 0.97, 6.62; p-trend=0.31). In analyses with exposure lagged by 25 years, there was an elevated risk of pharyngeal (RRT3=3.04; 95% CI: 1.45, 6.36; p-trend=0.07) and kidney (RRQ4=1.62; 95% CI: 1.15, 2.29; p-trend<0.005) cancers. Discussion: We observed suggestive associations with some malignancies in overall, age-specific, and lagged analyses. Associations with aggressive prostate cancer and NHL were apparent among those diagnosed at younger ages and with cancers of the pharynx and kidney, and soft tissue sarcomas were observed in lagged analyses. Further work is needed to confirm these observed associations and elucidate potential underlying mechanisms. https://doi.org/10.1289/EHP13684.https://cassyni-user-files-prod.s3.amazonaws.com/EVVTCT3BdrqpxMF9Ai8Y5L https://cassyni.com/events/VTyh89bxYMNqabgGSsCzLu/abstract https://cassyni-user-files-prod.s3.amazonaws.com/ReSpb6ezCVxoZVAKMRW6Zc https://cassyni.com/events/UVut4UyuPK2fNyaqekJRuX/seminar/qa https://cassyni.com/slides/outline/UVut4UyuPK2fNyaqekJRuX https://cassyni.com/events/UVut4UyuPK2fNyaqekJRuX/abstract https://cassyni-user-files-prod.s3.amazonaws.com/8Dhy5VFCA2PwYSx1nwkVga https://cassyni.com/events/UVut4UyuPK2fNyaqekJRuX?videoPreview=1 Latin American Federation of Biophysical Societies: Special Collection in Biophysical Reviews nohttps://cassyni.com/events/UVut4UyuPK2fNyaqekJRuX?videoPreview=12025-09-10T15:00:00+00:004827.4Springer Nature Physics CommunityWe are delighted to present this entirely free webinar to celebrate the publication of the second LAFEBS (Latin American Federation of Biophysical Societies) special collection in the journal Biophysical Reviews. As part of this webinar, we would like to invite you to LAFEBS, partner IUPAB (International Union of Pure and Applied Biophysics, co-owner of Biophysical Reviews) and some presentations by the authors of papers in the collection. The issue has been extremely successful, and we invite you to consult the papers here: https://link.springer.com/collections/eceighedfg https://cassyni-user-files-prod.s3.amazonaws.com/8Dhy5VFCA2PwYSx1nwkVga https://cassyni.com/slides/outline/H9LTNKHU87QibJsv67yPfB https://cassyni.com/events/H9LTNKHU87QibJsv67yPfB/abstract https://cassyni-user-files-prod.s3.amazonaws.com/V95HHDVcfgczFazWmJHM5Q https://cassyni.com/events/H9LTNKHU87QibJsv67yPfB?videoPreview=1 Unexplored microbial diversity from 2,500 food metagenomes and links with the human microbiomenohttps://cassyni.com/events/H9LTNKHU87QibJsv67yPfB?videoPreview=12024-09-19T11:00:00+00:00615.96Microbiome Virtual International ForumComplex microbiomes are part of the food we eat and influence our own microbiome, but their diversity remains largely unexplored. Here, we generated the open access curatedFoodMetagenomicData (cFMD) resource by integrating 1,950 newly sequenced and 583 public food metagenomes. We produced 10,899 metagenome-assembled genomes spanning 1,036 prokaryotic and 108 eukaryotic species-level genome bins (SGBs), including 320 previously undescribed taxa. Food SGBs displayed significant microbial diversity within and between food categories. Extension to >20,000 human metagenomes revealed that food SGBs accounted on average for 3% of the adult gut microbiome. Strain-level analysis highlighted potential instances of food-to-gut transmission and intestinal colonization (e.g., Lacticaseibacillus paracasei) as well as SGBs with divergent genomic structures in food and humans (e.g., Streptococcus gallolyticus and Limosilactobabillus mucosae). The cFMD expands our knowledge on food microbiomes, their role in shaping the human microbiome, and supports future uses of metagenomics for food quality, safety, and authentication.https://cassyni-user-files-prod.s3.amazonaws.com/V95HHDVcfgczFazWmJHM5Q https://cassyni.com/slides/outline/9iMNXjPiR1RBUpLdZz181s https://cassyni.com/events/9iMNXjPiR1RBUpLdZz181s/abstract https://cassyni-user-files-prod.s3.amazonaws.com/CGJ1iQCGHAastVBHJ31ihC https://cassyni.com/events/9iMNXjPiR1RBUpLdZz181s?videoPreview=1 Discussion with Dr. Andrew Gambino about chatbots and AInohttps://cassyni.com/events/9iMNXjPiR1RBUpLdZz181s?videoPreview=12023-04-28T12:00:00+00:002606.52Hong Kong Baptist UniversityIn this episode, Robby speaks with Dr. Andrew Gambino, an assistant professor at the University of Delaware, to delve into the fascinating world of chatbots and AI. They explore CASA and the distinctive ways in which individuals interact with AI and computers in contrast to human interactions. Moreover, they probe the features of ChatGPT and Bard to better understand their idiosyncrasies. The conversation takes a turn to discuss potential implications for workplaces and schools as AI technologies become widely adopted. They muse potential benefits for low-skilled workers that integrate AI into their workflows. The conversation then shifts to the potential implications of AI for society, including the power of AI to enable organizations to spread messages and interact with countless individuals meaningfully. Interestingly, even this video description was co-authored by ChatGPT!https://cassyni-user-files-prod.s3.amazonaws.com/CGJ1iQCGHAastVBHJ31ihC https://cassyni.com/slides/outline/QXPACo5AYL8dXy28qfnXBT https://cassyni.com/events/QXPACo5AYL8dXy28qfnXBT/abstract https://cassyni-user-files-prod.s3.amazonaws.com/BUmx7QZ8ccxKJQ3gms7qCJ https://cassyni.com/events/QXPACo5AYL8dXy28qfnXBT?videoPreview=1 The Hong Kong Shuffle Poetry Readingnohttps://cassyni.com/events/QXPACo5AYL8dXy28qfnXBT?videoPreview=12020-09-19T12:00:00+00:003160.0Hong Kong Baptist UniversityThe Shuffle Poetry Series presents a celebration of Hong Kong poetics, both in HK and abroad with readings from: Mary Jean Chan, Kit Fan, Jason Eng Hun Lee, David McKirdy, Jennifer Wong and Nicholas Wong. In this extraordinary time, hear an exciting range of HK voices, curated by Jennifer Wong and presented by Jennifer and Gale Burns.https://cassyni-user-files-prod.s3.amazonaws.com/BUmx7QZ8ccxKJQ3gms7qCJ https://cassyni.com/slides/outline/7jkxLzocfBCRP74QD29BbK https://cassyni.com/events/7jkxLzocfBCRP74QD29BbK/abstract https://cassyni-user-files-prod.s3.amazonaws.com/VqgVES6BtwcrsNM8dyE9U https://cassyni.com/events/7jkxLzocfBCRP74QD29BbK?videoPreview=1 Rethink, Revolve and Reshape: Artificial Intelligence & Transformations in Teaching and Assessmentnohttps://cassyni.com/events/7jkxLzocfBCRP74QD29BbK?videoPreview=12023-05-02T12:00:00+00:005368.04Hong Kong Baptist UniversityThe rapid emergence of generative artificial intelligence (AI) tools necessitates a critical re-evaluation of teaching and assessment practices in higher education. This discussion explores both the transformative potential and significant challenges posed by AI in academic contexts. AI-based learning interventions can offer context-specific coaching, emotional support, and metacognitive guidance to learners. However, their adoption is hindered by requirements for robust infrastructure, curriculum alignment, and comprehensive teacher training, particularly in developing regions. To address the integration of generative AI, several approaches are proposed. Teachers must develop AI literacy to understand the capabilities and limitations of tools like ChatGPT, enabling them to transition into roles as learning facilitators. Assessment strategies should evolve to include viva voce examinations, assignments requiring critical analysis of AI-generated text, and tasks focused on post-editing AI outputs. The development of large linguistic corpora, such as the 6.5 million Chinese-English Political Interpreting Corpus, supports research into translation patterns and the application of AI-related tools (e.g., computer-assisted interpreting/translation, automatic transcription) in language disciplines. Key implications highlight the need for ethical considerations, including addressing misinformation, mitigating digital divides, and ensuring the ethical sourcing of AI training data. Educational institutions are encouraged to foster critical thinking, problem-solving, and creativity as core skills, enabling students to discern the quality and reliability of AI-generated content. Ultimately, while AI augments human capabilities, the unique roles of teachers in curating, validating, and caring for student learning remain indispensable. Policy development should prioritize student voice and address issues of information accessibility and equity.https://cassyni-user-files-prod.s3.amazonaws.com/VqgVES6BtwcrsNM8dyE9U https://cassyni.com/slides/outline/4HDj2DGwayKnMQkqZMmE4V https://cassyni.com/events/4HDj2DGwayKnMQkqZMmE4V/abstract https://cassyni-user-files-prod.s3.amazonaws.com/WBiDC3Vswgw4DUKBWp9PU https://cassyni.com/events/4HDj2DGwayKnMQkqZMmE4V?videoPreview=1 Horst Eisfelder: Diasporic Life in Shanghai's State of Exceptionnohttps://cassyni.com/events/4HDj2DGwayKnMQkqZMmE4V?videoPreview=12023-11-09T12:00:00+00:005224.28Hong Kong Baptist UniversityAfter fleeing Berlin a few weeks before Kristallnacht and arriving in Shanghai with his family in late November 1938, Horst Eisfelder (1925-2023) became one of the most prolific photographers of the ‘Shanghai Ghetto’ before emigrating to Australia in May 1947. Embedded within the history and theory of photography, this presentation considers his images of the city of Shanghai as well as the Designated Area for Stateless Refugees as vital representations through which to understand the constitution of diasporic life for the diverse Jewish communities who survived the war in this polyglot port of last resort.https://cassyni-user-files-prod.s3.amazonaws.com/WBiDC3Vswgw4DUKBWp9PU https://cassyni.com/slides/outline/EeqQzZrxoaxCsv3yaTi7k1 https://cassyni.com/events/EeqQzZrxoaxCsv3yaTi7k1/abstract https://cassyni-user-files-prod.s3.amazonaws.com/K7R8G7tgRTaY4159zfsTKL https://cassyni.com/events/EeqQzZrxoaxCsv3yaTi7k1?videoPreview=1 Motivations and Challenges in Participating in Work-integrated Learning: The Industry Partner Perspectivesnohttps://cassyni.com/events/EeqQzZrxoaxCsv3yaTi7k1?videoPreview=12025-02-27T12:00:00+00:003731.4Hong Kong Baptist UniversityMany vocational education and training programs are enthusiastic to recruit industry employers to provide workplace exposure and work-integrated learning opportunities. However, low industry motivation to participate has sometimes posed an issue. In this study, we examine what motivates companies to participate as an industry partner and the perceived challenges in participating. A qualitative interview study was conducted among 15 current and potential industry partners. Results indicated that the main motivations and perceived benefits of serving as industry partners were attracting talent, giving back to society, enhancing company reputation, and promoting corporate learning. Other considerations included the reputation of the educational institutions, existing partners, level of commitment, and how much of a contribution the partner could make. Employee turnover of industry partners and communication between partners and education providers were perceived as challenges. Recommendations informing vocational education programs’ efforts to initiate, maintain, and strengthen industry engagement were proposed.https://cassyni-user-files-prod.s3.amazonaws.com/K7R8G7tgRTaY4159zfsTKL https://cassyni.com/slides/outline/F9V23FWVF3WFsgasAtzv1K https://cassyni.com/events/F9V23FWVF3WFsgasAtzv1K/abstract https://cassyni-user-files-prod.s3.amazonaws.com/RXLmog2Ysv76b51dAgbqa6 https://cassyni.com/events/F9V23FWVF3WFsgasAtzv1K?videoPreview=1 Understanding “Blackness” in Hong Kong: Representations of Africa in Hong Kong Popular Medianohttps://cassyni.com/events/F9V23FWVF3WFsgasAtzv1K?videoPreview=12021-05-07T12:00:00+00:001155.6Hong Kong Baptist UniversityThis paper studies the representations of Africans and African cultures in Hong Kong popular media since the 1990’s and its political, social, and cultural significance. Representations of the African continent in Hong Kong popular culture define the local’s understanding of African peoples and cultures. On one hand, some representations continue to reproduce long held stereotypes by constructing African cultures as the city’s inferior binary opposition; on the other hand, some attempt to do away with the sense of “othering” and achieve empathetic cultural exchanges. By analysing the construction of “African-ness” in these representations, this paper shows that African cultures are constantly portrayed in relation to Hong Kong’s under the presupposition of assimilation. It is by studying the absences and presences of “African-ness” in locally produced movies, songs, and variety shows that it could be shown that Africa is often narrated as the subordinate of the local. Significantly, this hierarchy not only predetermines but also crystalizes the local people’s understanding of Africa. This paper thus studies how these representations incur ideologies and define Africa and African cultures in the city.https://cassyni-user-files-prod.s3.amazonaws.com/RXLmog2Ysv76b51dAgbqa6 https://cassyni.com/slides/outline/N498yNqYM3N9B2YaHystTX https://cassyni.com/events/N498yNqYM3N9B2YaHystTX/abstract https://cassyni-user-files-prod.s3.amazonaws.com/JRU3Sxim1vjziVfuHkJHv6 https://cassyni.com/events/N498yNqYM3N9B2YaHystTX?videoPreview=1 Spinning Outwards to a Larger Wenohttps://cassyni.com/events/N498yNqYM3N9B2YaHystTX?videoPreview=12021-06-18T12:00:00+00:005512.4Hong Kong Baptist UniversityThe “Creative, Self and Society” Group of HKBU’s Faculty of Arts is pleased to announce an online zoom Speakers’ Series in 2021 for all secondary school and university students in Hong Kong, with the theme of “Recomposing the Self.” In times of rapid changes both domestically and globally, how can young people foster their creativity and cultivate their critical thinking to navigate the changing environment around them? The more the world is changing, the more we need to consider how to refashion our self in order to think about our relationship with society, to adapt to changes, and to prepare how to contribute to it. In many ways, around the world today the increasing interests of youth on issues of climate change, impact of social media, social inequality, multiculturalism and diversity, and so on, are an indication of their yearning to “recompose” their sense of identity and selfhood, so that they may reactivate their community connections and become better prepared to meet the challenges of their generation. Our zoom series aims to use a storytelling approach to stimulate young people to recognize the need (and the art) of flexibly thinking about ourselves and our relation to a society with major social transformations. We have invited 5 distinctive individuals who, in their own unique ways, learn how to refashion themselves because they recognize that somehow they are different and that they are not satisfied with the common ways of being. Striving with their own sense of creativity, they have each struck a new sense of well-being and self-value, and used their examples to contribute to the public good.https://cassyni-user-files-prod.s3.amazonaws.com/JRU3Sxim1vjziVfuHkJHv6 https://cassyni.com/events/Xw7Du3n38CSU2YYboYeFbT/abstract https://cassyni-user-files-prod.s3.amazonaws.com/tr4RphZUiWma5g6WzikMt https://cassyni.com/events/Xw7Du3n38CSU2YYboYeFbT?videoPreview=1 T11 Image Classificationnohttps://cassyni.com/events/Xw7Du3n38CSU2YYboYeFbT?videoPreview=12023-08-07T12:00:00+00:00607.32Hong Kong Baptist UniversityAbstract not yet added.https://cassyni-user-files-prod.s3.amazonaws.com/tr4RphZUiWma5g6WzikMt https://cassyni.com/slides/outline/H7f6WYNHxTq7mvqEHWAtjP https://cassyni.com/events/H7f6WYNHxTq7mvqEHWAtjP/abstract https://cassyni-user-files-prod.s3.amazonaws.com/KVaq99RNGvreEJb43KpQuc https://cassyni.com/events/H7f6WYNHxTq7mvqEHWAtjP?videoPreview=1 Annotate Special Sounds Using IPA Reference — Ep.07nohttps://cassyni.com/events/H7f6WYNHxTq7mvqEHWAtjP?videoPreview=12021-09-27T12:00:00+00:00225.28Hong Kong Baptist UniversityAccurate phonetic annotation of diverse speech data presents challenges, particularly when encountering unfamiliar accents or 'special sounds' for which standard International Phonetic Alphabet (IPA) symbols are not immediately obvious. This can be a significant hurdle for phonetics beginners. This study outlines a practical, reference-based approach designed to assist in identifying appropriate IPA symbols. The method involves analyzing a target sound from speech data, such as the initial bilabial trill in a non-standard pronunciation of 'but' or a specific vowel sound in 'hurt.' These unfamiliar sounds are then systematically compared against extensive audio examples available on online IPA reference websites, which illustrate the precise pronunciation of individual symbols. Once a close phonetic match is identified and verified auditorily, the corresponding IPA symbol is copied directly from the online resource. This symbol is subsequently pasted into phonetic annotation software, such as Praat, completing the transcription for the challenging segment. This streamlined process demonstrates how online auditory references can significantly facilitate the initial identification and annotation of less familiar sounds for novice phoneticians. However, it is important to note that while this method aids in preliminary symbol selection, accurate and nuanced IPA transcription fundamentally requires comprehensive formal training.https://cassyni-user-files-prod.s3.amazonaws.com/KVaq99RNGvreEJb43KpQuc https://cassyni.com/slides/outline/Kau7jxbv9kbc8sJnqC5XTK https://cassyni.com/events/Kau7jxbv9kbc8sJnqC5XTK/abstract https://cassyni-user-files-prod.s3.amazonaws.com/GWczAiXmUkiGLUWVtqJ4Aa https://cassyni.com/events/Kau7jxbv9kbc8sJnqC5XTK?videoPreview=1 Chinese Journalism Studies Network Launchnohttps://cassyni.com/events/Kau7jxbv9kbc8sJnqC5XTK?videoPreview=12023-09-22T12:00:00+00:003988.72Hong Kong Baptist UniversityThe speakers in this roundtable are launching a new Chinese Journalism Studies Network to sustain and energize research in this area. This international interest group aims to facilitate knowledge exchange, foster collaborative research, and advocate for improved research and publishing conditions. This roundtable is the first in a series of events planned for the new academic year. The speakers reviewed the current status of the field and suggested new research directions that can illuminate media dynamics in an important part of the world.https://cassyni-user-files-prod.s3.amazonaws.com/GWczAiXmUkiGLUWVtqJ4Aa https://cassyni.com/slides/outline/SVyaPXfGJAMPdgJNCdeTc1 https://cassyni.com/events/SVyaPXfGJAMPdgJNCdeTc1/abstract https://cassyni-user-files-prod.s3.amazonaws.com/QPQi1XVp7HQ7xjXBDsqvoY https://cassyni.com/events/SVyaPXfGJAMPdgJNCdeTc1?videoPreview=1 Challenges to Religious Worldviewsnohttps://cassyni.com/events/SVyaPXfGJAMPdgJNCdeTc1?videoPreview=12025-08-13T12:00:00+00:006321.96Hong Kong Baptist UniversityThis seminar explores the multifaceted intersections of religion, artificial intelligence, and digital communication. One presentation argues that computational and theological reasoning share a crucial insight: adequacy relies on context-sensitivity. Drawing parallels between Large Language Models (e.g., BERT, XLM-RoBERTa, BLOOM) and a social-practical account of Christian doctrine, a triadic framework for theological adequacy (semantic-pragmatic, pastoral, apostolic) is proposed, emphasizing that engaging global Christian diversity improves discernment. A second study conducts a trilogue between the ANI-AGI-ASI framework, Christian theology, and Daoist thought to re-evaluate human nature. It suggests that artificial narrow intelligence (ANI) highlights humanity's co-creative role with technology, artificial general intelligence (AGI) underscores human embodiedness (proposing a "multidimensional psycho-pneumo-somatic unity"), and artificial superintelligence (ASI) illuminates the human quest for immortality, informing a constructive theological anthropology. The third investigation examines how joy is pursued in online Hong Kong Christian communities, integrating positive psychology and sociology of religion. It identifies both barriers to joy (e.g., aggressive online discourse) and facilitating factors (e.g., bottom-up leadership, creative engagement with social justice). Collectively, these analyses advocate for a more inclusive and context-attentive theological engagement, a refined understanding of human nature in dialogue with technological advancements, and a mindful approach to fostering spiritual flourishing and community in digital spaces.https://cassyni-user-files-prod.s3.amazonaws.com/QPQi1XVp7HQ7xjXBDsqvoY https://cassyni.com/slides/outline/SzdBSDJnjcuSdSqFo4wFsK https://cassyni.com/events/SzdBSDJnjcuSdSqFo4wFsK/abstract https://cassyni-user-files-prod.s3.amazonaws.com/P1PRu4TcNKRqLFGgFZxrKG https://cassyni.com/events/SzdBSDJnjcuSdSqFo4wFsK?videoPreview=1 St. John’s College Authors on the Value of a Liberal Arts Educationnohttps://cassyni.com/events/SzdBSDJnjcuSdSqFo4wFsK?videoPreview=12024-05-17T12:00:00+00:001039.8Hong Kong Baptist UniversityThis seminar explores the contemporary value and challenges of a liberal arts education, particularly in the context of increasing demands for vocational utility in higher education. A central argument asserts that a traditional liberal education cultivates crucial skills in critical thinking, articulate communication, and precise writing by engaging with foundational texts across history, philosophy, and literature. This approach is posited to equip individuals with a deeper understanding of themselves, society, and fundamental principles, thereby enhancing civic engagement. While often perceived as lacking immediate vocational utility, a liberal arts foundation is presented as providing versatile skills that facilitate diverse career paths and foster lifelong curiosity and adaptability. Examples include individuals successfully entering fields from fiction writing to physics and military specialisation. The discussion also highlights a global embrace of liberal arts education in regions like India and Hong Kong, contrasting with its perceived decline in the United States. Furthermore, the study of ancient texts, such as medieval Sanskrit, is demonstrated to offer profound context for universal human experiences—like the fear of illness and death—connecting historical insights to contemporary life. Ultimately, a liberal arts education is framed as a transformative privilege that should be broadly accessible, fundamentally shaping a person's life beyond occupational considerations.https://cassyni-user-files-prod.s3.amazonaws.com/P1PRu4TcNKRqLFGgFZxrKG https://cassyni.com/slides/outline/5kkCSpVDrw68Vgr5vWj7iV https://cassyni.com/events/5kkCSpVDrw68Vgr5vWj7iV/abstract https://cassyni-user-files-prod.s3.amazonaws.com/KAx91rF82dvgtj3SErb6Ez https://cassyni.com/events/5kkCSpVDrw68Vgr5vWj7iV?videoPreview=1 Crying for Justice: The Impact of Public Opinion on the Local Judiciary during Mingnohttps://cassyni.com/events/5kkCSpVDrw68Vgr5vWj7iV?videoPreview=12025-01-10T12:00:00+00:005253.6Hong Kong Baptist UniversityThis study examines the influence of public opinion on the local judiciary during the Ming dynasty, focusing on the interplay between legal principles and popular sentiment in judicial decision-making. Drawing primarily on late Ming casebooks, especially those authored by Yan Junyan, prefectural judge of Canton, the analysis reveals a judicial system characterized by procedural openness: court hearings were public, records were posted for inspection, and litigants and observers could voice complaints, thereby enabling public scrutiny of judicial conduct. Public opinion functioned as both a check on judicial excesses and a source of pressure, compelling judges to balance legal statutes with communal sentiments. Cases such as the banditry trial of Li Quanshao illustrate how mass protests by local communities influenced judges to reconsider evidence and mitigate punishments, while other instances demonstrate judges’ efforts to maintain independence by resisting popular demands unsupported by solid evidence. The findings highlight a judicial dilemma wherein magistrates sought to uphold legal integrity and imperial statutes while managing the risks of public dissatisfaction, which could threaten local governance stability. Judges employed legal knowledge and procedural transparency as safeguards against accusations of bias or tyranny, yet they also tactfully accommodated public opinion to preserve social order. This dual role underscores the complexity of judicial authority in Ming China, where public opinion was a double-edged sword—capable of promoting justice but also of undermining legal rigor. The study contributes to understanding the nuanced relationship between law, society, and governance in premodern China and suggests avenues for further research on judicial independence and popular participation in historical legal systems.https://cassyni-user-files-prod.s3.amazonaws.com/KAx91rF82dvgtj3SErb6Ez https://cassyni.com/events/2JCy82xYnjDVTzYXGrMABf/abstract https://cassyni-user-files-prod.s3.amazonaws.com/EEViJKZxPwq6Wh4exoTyjk https://cassyni.com/events/2JCy82xYnjDVTzYXGrMABf?videoPreview=1 EPS24 Inside the China Storynohttps://cassyni.com/events/2JCy82xYnjDVTzYXGrMABf?videoPreview=12025-10-20T12:00:00+00:003593.12Hong Kong Baptist UniversityHost Wenchi Yu speaks with Wang Xiangwei, former editor-in-chief of the South China Morning Post (SCMP), about covering China over the last three decades, as well as Hong Kong after 2019. Wang led the expansion and digital transformation of SCMP's China coverage, striving to provide insider, balanced, and insightful reporting amid complex political pressures from both Beijing and Hong Kong, all while maintaining editorial independence. He witnessed and navigated Hong Kong’s changing political landscape, including the impacts of the National Security Law, and advocates for Hong Kong's unique role as a distinctive, open, and window into China. Wang Xiangwei thinks Hong Kong’s role should be as a unique capitalist enclave within China that acts as a vital bridge and “superconnector” between China and the rest of the world. Despite political pressures and challenges under “one country, two systems,” Hong Kong should preserve its openness, rule of law, and global connectivity to remain indispensable for China’s modernization and for international capital seeking access to China and Asia. Wang emphasizes that Hong Kong must proactively shape Beijing’s perception of its importance rather than passively yield its future, thus maintaining its distinctive identity and future prosperity.​ After leaving his editorial post, Wang now teaches journalism, continuing to contribute a perspective on China’s global rise and media challenges, and remains an avid writer and observer of China.https://cassyni-user-files-prod.s3.amazonaws.com/EEViJKZxPwq6Wh4exoTyjk https://cassyni.com/slides/outline/4mSzMTCAz1yypw25pYFnub https://cassyni.com/events/4mSzMTCAz1yypw25pYFnub/abstract https://cassyni-user-files-prod.s3.amazonaws.com/XW6aq1qZhNZtYafzzmgJGW https://cassyni.com/events/4mSzMTCAz1yypw25pYFnub?videoPreview=1 Hollywood in China: Behind the Scenes of the World's Largest Movie Marketnohttps://cassyni.com/events/4mSzMTCAz1yypw25pYFnub?videoPreview=12022-10-04T12:00:00+00:003415.04Hong Kong Baptist UniversityJoin the Rajawali Foundation institute for Asia for a discussion with Professor Ying Zhu, author of Hollywood in China: Behind the Scenes of the World’s Largest Movie Market. Professor Zhu’s conversation will be moderated by Edward Cunningham, Director of Rajawali Foundation institute for Asia China Programs and of the Asia Energy and Sustainability Initiative at Harvard Kennedy School.https://cassyni-user-files-prod.s3.amazonaws.com/XW6aq1qZhNZtYafzzmgJGW https://cassyni.com/events/6GZxHwmyDYYo2Nq33i6aso/seminar/qa https://cassyni.com/slides/outline/6GZxHwmyDYYo2Nq33i6aso https://cassyni.com/events/6GZxHwmyDYYo2Nq33i6aso/abstract https://cassyni-user-files-prod.s3.amazonaws.com/AESGJURRNzeX9c3fuwq4na https://cassyni.com/events/6GZxHwmyDYYo2Nq33i6aso?videoPreview=1 Bound-Preserving High Order Schemes for Hyperbolic Equations: Survey and Recent Developmentsnohttps://cassyni.com/events/6GZxHwmyDYYo2Nq33i6aso?videoPreview=12021-09-06T14:00:00+00:003724.4Journal of Computational PhysicsSolutions to many hyperbolic equations have convex invariant regions, for example solutions to scalar conservation laws satisfy maximum principle, solutions to compressible Euler equations satisfy positivity-preserving property for density and internal energy, etc. It is however a challenge to design schemes whose solutions also honor such invariant regions. This is especially the case for high order accurate schemes. In this talk we will first survey strategies in the literature to design high order bound-preserving schemes, including the general framework in constructing high order bound-preserving finite volume and discontinuous Galerkin schemes for scalar and systems of hyperbolic equations through a simple scaling limiter and a convex combination argument based on first order bound-preserving building blocks, and various flux limiters to design high order bound-preserving finite difference schemes. We will then discuss a few recent developments, including high order bound-preserving schemes for relativistic hydrodynamics, high order discontinuous Galerkin Lagrangian schemes, high order discontinuous Galerkin methods for radiative transfer equations, high order discontinuous Galerkin methods for MHD, and implicit bound-preserving schemes. Numerical tests demonstrating the good performance of these schemes will be reported.https://cassyni-user-files-prod.s3.amazonaws.com/AESGJURRNzeX9c3fuwq4na https://cassyni.com/slides/outline/H8v7esZB5hWpQ9RtobtmBs https://cassyni.com/events/H8v7esZB5hWpQ9RtobtmBs/abstract https://cassyni-user-files-prod.s3.amazonaws.com/HWMPEn8syc9MBksF3zAGyU https://cassyni.com/events/H8v7esZB5hWpQ9RtobtmBs?videoPreview=1 Acoustic metasurfaces and their application to turbulent flownohttps://cassyni.com/events/H8v7esZB5hWpQ9RtobtmBs?videoPreview=12021-06-29T14:00:00+00:004022.08MetaMATThe use of surface structures can have a significant impact on the pressure fluctuations that manifest above them. Acoustic metamaterials that comprise structured surfaces have been designed to influence the acoustic pressure field for a variety of applications such as acoustic filtering, focusing, and absorption, whilst in the aerodynamics of turbulent boundary layer flows, surface treatments can cause significant changes to the sound generated from, and pressure fluctuations present within, the flow. So, the question arises, can we apply acoustic metamaterial concepts as a strategy to influence a turbulent flow? In principle, metasurfaces used to control acoustic fields should also respond to evanescent pressure fluctuations generated by turbulence. However, interfacing a metasurface and boundary layer poses some challenges, not least in the large disparity between acoustic and flow scales at low Mach number, and the need to avoid metasurface configurations that generate drag or other undesirable flow effects. In this talk I will discuss our recent work on acoustic surface waves and their application to a turbulent fluid flow. First I will talk about the characteristics and structures that support acoustic surface wave propagation in a quiescent ‘wholly acoustics’ environment. I will then present the strategy developed with collaborators at Virginia Tech, that interfaces a cavity-type metasurface with a turbulent flow using a hydrodynamically smooth but acoustically transparent membrane. Our experiments demonstrate the excitation of a bound acoustic mode using the stochastic near-field pressure fluctuations of a turbulent flow. The tested metasurfaces demonstrate a route for acoustic surface mode dispersions with reduced phase velocities to match to the convective velocity of the turbulent structures.We view this as an important first step in interfacing flows and metamaterials, with potential applications to the control of flow-generated edge noise or energy harvesting.https://cassyni-user-files-prod.s3.amazonaws.com/HWMPEn8syc9MBksF3zAGyU https://cassyni.com/slides/outline/5HKzRqWh9MJ1JSTEeWL1zm https://cassyni.com/events/5HKzRqWh9MJ1JSTEeWL1zm/abstract https://cassyni-user-files-prod.s3.amazonaws.com/5SYBuEX8FxcWW6bRuE8n9L https://cassyni.com/events/5HKzRqWh9MJ1JSTEeWL1zm?videoPreview=1 Traveling wave solutions to the free boundary Navier-Stokes equationsnohttps://cassyni.com/events/5HKzRqWh9MJ1JSTEeWL1zm?videoPreview=12021-05-06T15:00:00+00:003861.88Partial Differential Equations and ApplicationsConsider a layer of viscous incompressible fluid bounded below by a flat rigid boundary and above by a moving boundary. The fluid is subject to gravity, surface tension, and an external stress that is stationary when viewed in a coordinate system moving at a constant velocity parallel to the lower boundary. The latter can model, for instance, a tube blowing air on the fluid while translating across the surface. In this talk we will detail the construction of traveling wave solutions to this problem, which are themselves stationary in the same translating coordinate system. While such traveling wave solutions to the Euler equations are well-known, to the best of our knowledge this is the first construction of such solutions with viscosity. This is joint work with Giovanni Leoni.https://cassyni-user-files-prod.s3.amazonaws.com/5SYBuEX8FxcWW6bRuE8n9L https://cassyni.com/slides/outline/KcA8tHnoGzHJm5uTMHoPuo https://cassyni.com/events/KcA8tHnoGzHJm5uTMHoPuo/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Kc7CggdrqoVmHxNUDXBWni https://cassyni.com/events/KcA8tHnoGzHJm5uTMHoPuo?videoPreview=1 Nonlinear Waves and Flexible Elastic Metamaterialsnohttps://cassyni.com/events/KcA8tHnoGzHJm5uTMHoPuo?videoPreview=12021-02-09T14:00:00+00:005955.64MetaMATFlexible elastic metamaterials can be described as artificial structures, designed to be highly compliant and capable of withstanding large elastic deformations. Their current significance lies in the fact that they possess a number of unusual properties that can be controlled and, in addition, they belong to an extremely large design space. While their static character has been widely studied, their dynamic properties are still in their early stages, especially with regard to their non-linear dynamics. Nevertheless, we recall here that these non-linear properties can be designed in a rational way, allowing the development of metamaterials for the control of large amplitude elastic waves [1-5]. In this context, I synthesize in this talk a set of our recent results on the propagation of nonlinear waves in these flexible elastic metamaterials [1-10], and I will draw up possible perspectives from these initiated directions, ranging from vibration control, toy models for fundamental wave physics, to possible practical applications.https://cassyni-user-files-prod.s3.amazonaws.com/Kc7CggdrqoVmHxNUDXBWni https://cassyni.com/slides/outline/XxNF3NxvFS8Aem9GKeN83w https://cassyni.com/events/XxNF3NxvFS8Aem9GKeN83w/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Enhh98XqMWL3deL3Qrv7gz https://cassyni.com/events/XxNF3NxvFS8Aem9GKeN83w?videoPreview=1 Topological metamaterials for robust signal and energy manipulationnohttps://cassyni.com/events/XxNF3NxvFS8Aem9GKeN83w?videoPreview=12020-09-08T14:00:00+00:005648.2MetaMATTopological metamaterials are artificially engineered structures that confer to the waves that propagate through them a property, for example the presence of a given mode, that is robust to continuous modifications of the metamaterial, such as geometrical deformations, local defects, or irregularities in the wave path. In this talk, I will first explore how robust topological modes can be leveraged as building blocks to engineer resilient scattering responses1,2. Such topological scattering, which enables filtering signals without stringent requirements on the system’s geometry3, is experimentally demonstrated with acoustic waves. We will then discuss the relevance of topology to robust energy concentration or manipulation, in particular using second order topological wave insulators leveraging non-linearity4, or combining topological concepts with classical metamaterial effects such as near-zero-index supercoupling5. Altogether, this talk demonstrates that the field of topology is now sufficiently mature to move from purely physics-driven explorations towards exciting application-oriented developments6.https://cassyni-user-files-prod.s3.amazonaws.com/Enhh98XqMWL3deL3Qrv7gz https://cassyni.com/slides/outline/4J2nLUDeGSBrdgdEYXrhBs https://cassyni.com/events/4J2nLUDeGSBrdgdEYXrhBs/abstract https://cassyni-user-files-prod.s3.amazonaws.com/CC9FsZThHjPSZm1v5rLXae https://cassyni.com/events/4J2nLUDeGSBrdgdEYXrhBs?videoPreview=1 Designing Tests for Academic Purposesnohttps://cassyni.com/events/4J2nLUDeGSBrdgdEYXrhBs?videoPreview=12021-07-02T16:00:00+00:003321.04Linguistics and Applied Language StudiesAcademic collocations (e.g., empirical evidence, key element) are important as they occur in a wide range of registers and disciplines. Corpus-based word lists of academic collocations are valuable resources for EAP pedagogy, and one useful application of such word lists is for test development. The focus of this talk is designing the Academic Collocation Tests based on the Academic Collocation List (Ackermann & Chen, 2013). The six steps of creating the tests will be presented, which aim to lay the groundwork for further application of multiword-unit lists into developing tests. Benefits and challenges of wordlist-based test development will then be discussed, followed by implications for testing. Integrated writing (IW) tests or reading-writing tests are gaining popularity because they are claimed to be authentic and valid (Weigle, 2004). However, although IW tests aim to demarcate students' general academic preparedness levels for university, the majority of these tests are not strong enough for such purposes to meet the requirements of university courses. To understand the target language use (TLU) domain requirements, reading and writing requirements in first-year humanities and social sciences courses at VUW were analysed. Based on these requirements, an IW test was developed. The stages of test development, related challenges, and opportunities will be presented. Recommendations will be made for EAP teaching and IW testing.https://cassyni-user-files-prod.s3.amazonaws.com/CC9FsZThHjPSZm1v5rLXae https://cassyni.com/slides/outline/Na5PH2BqK6Xfci8kcBij6D https://cassyni.com/events/Na5PH2BqK6Xfci8kcBij6D/abstract https://cassyni-user-files-prod.s3.amazonaws.com/NBxGbS3dw3hhwukhYPS9k https://cassyni.com/events/Na5PH2BqK6Xfci8kcBij6D?videoPreview=1 Modal approximations for plasmonic resonators in the time domain and applications to super-localisationnohttps://cassyni.com/events/Na5PH2BqK6Xfci8kcBij6D?videoPreview=12022-02-01T14:00:00+00:004442.28MetaMATWe study the possible expansion of the electromagnetic field scattered by a strictly convex metallic nanoparticle with dispersive material parameters placed in a homogeneous medium in a low-frequency regime as a sum of modes oscillating at complex frequencies (diverging at infinity), known in the physics literature as the quasi-normal modes expansion. We show that such an expansion is valid in the static regime and that we can approximate the electric field with a finite number of modes. We then use perturbative spectral theory to show the existence, in a certain regime, of plasmonic resonances as poles of the resolvent for Maxwell’s equations with non-zero frequency. We show that, in the time domain, the electric field can be written as a sum of modes oscillating at complex frequencies. We introduce renormalised quantities that do not diverge exponentially at infinity. We present numerical simulations in two dimensions to corroborate our results. We illustrate the usefulness of our method on the super-localisation of a point-like emitter in a resonant environment.https://cassyni-user-files-prod.s3.amazonaws.com/NBxGbS3dw3hhwukhYPS9k https://cassyni.com/slides/outline/8FGrwCRcapU6JYNwByBnoo https://cassyni.com/events/8FGrwCRcapU6JYNwByBnoo/abstract https://cassyni-user-files-prod.s3.amazonaws.com/6P6N4FsiNZx2QxtZvtwFsL https://cassyni.com/events/8FGrwCRcapU6JYNwByBnoo?videoPreview=1 On the stability of the laminar boundary layer beneath a Stokes wavenohttps://cassyni.com/events/8FGrwCRcapU6JYNwByBnoo?videoPreview=12022-04-12T10:40:00+00:001494.48Water WavesThe linear stability of the laminar boundary layer flow of a Stokes wave in deep waters is investigated by means of a 'momentary' criterion of instability for unsteady flows. In the parameter range investigated, it is found that the flow is stable to 2-D perturbations. The least stable eigenmode of the resulting Orr-Sommerfield spectrum attains its maximum beneath the boundary layer of the Stokes wave. Moreover, an analysis of the associated pseudospectrum indicates that the laminar flow when modified by imperfections is unstable due to the non-normality of the Orr-Sommerfeld operator, and the unstable pseudoeigenmodes tend to peak within the boundary layer. The laminar flow of the Stokes wave is also stable to 3-D streamwise-independent perturbations. Instability is observed for the laminar flow with imperfections. The associated unstable pseudo-eigenmodes are streamwise vortical rolls similar to Langmuir cells. The laminar boundary layer flow of a Stokes wave appears to be stable to infinitesimal perturbations, but it may likely be unstable to finite perturbations, as in Poiseuille pipe flows. The present results are supportive of the recent experimental evidence of spontaneous occurrence of turbulence beneath unforced nonbreaking surface waves.https://cassyni-user-files-prod.s3.amazonaws.com/6P6N4FsiNZx2QxtZvtwFsL https://cassyni.com/slides/outline/UVoPbxvMmsKkoNP5UK9zcD https://cassyni.com/events/UVoPbxvMmsKkoNP5UK9zcD/abstract https://cassyni-user-files-prod.s3.amazonaws.com/5CGdEq1LCUhA527aihVR7c https://cassyni.com/events/UVoPbxvMmsKkoNP5UK9zcD?videoPreview=1 Mean curvature flow through neck-singularitiesnohttps://cassyni.com/events/UVoPbxvMmsKkoNP5UK9zcD?videoPreview=12021-10-14T13:00:00+00:003570.32Partial Differential Equations and ApplicationsIn this talk, I will explain our recent result that mean curvature flow through neck-singularities is unique. The key is a classification theorem for ancient asymptotically cylindrical flows that describes all potential blowup limits near a neck-singularity. In particular, this confirms Ilmanen’s mean-convex neighborhood conjecture, and more precisely gives a canonical neighborhood theorem for neck-singularities. Furthermore, assuming the multiplicity-one conjecture, we conclude that for embedded two-spheres mean curvature flow through singularities is well-posed. The two-dimensional case is joint work with Choi and Hershkovits, and the higher-dimensional case is joint with Choi, Hershkovits and White.https://cassyni-user-files-prod.s3.amazonaws.com/5CGdEq1LCUhA527aihVR7c https://cassyni.com/slides/outline/FAJ5MWTBvWNL9xTGA56P8h https://cassyni.com/events/FAJ5MWTBvWNL9xTGA56P8h/abstract https://cassyni-user-files-prod.s3.amazonaws.com/6gACWwdwMbzoMnbS6Aypna https://cassyni.com/events/FAJ5MWTBvWNL9xTGA56P8h?videoPreview=1 Normalized solutions of nonlinear elliptic problemsnohttps://cassyni.com/events/FAJ5MWTBvWNL9xTGA56P8h?videoPreview=12020-09-07T15:00:00+00:003081.88Partial Differential Equations and ApplicationsThe talk will be concerned with the existence of L 2 normalized solutions to nonlinear elliptic equations and systems.A model problem is the system of nonlinear Schrödinger equations(−∆u + λ1u = µ1u 3 + βuv2 in R 3−∆ v + λ2v = µ2v 3 + βu 2 v in R 3 with normalization constraints Z R3 u 2 = a 2 and Z R3 v 2 = b 2 .Whereas nonlinear elliptic equations and systems have been investigated intensively since the 1960 s, in comparison surprisingly little is known about solutions with prescribed L 2 norms.We discuss this problem and survey recent results.The talk is based on joint work with Louis Jeanjean, Yanyan Liu, Zhaoli Liu, Nicola Soave, Xuexiu Zhong, Wenming Zou.https://cassyni-user-files-prod.s3.amazonaws.com/6gACWwdwMbzoMnbS6Aypna https://cassyni.com/slides/outline/2KTzGN9RuxuC6D9Bnx52e9 https://cassyni.com/events/2KTzGN9RuxuC6D9Bnx52e9/abstract https://cassyni-user-files-prod.s3.amazonaws.com/MHXJgrqoJ6wzEFUeRDfHTC https://cassyni.com/events/2KTzGN9RuxuC6D9Bnx52e9?videoPreview=1 SITAEL's high-power Hall thrusters and air-breathing electric propulsionnohttps://cassyni.com/events/2KTzGN9RuxuC6D9Bnx52e9?videoPreview=12021-11-24T16:00:00+00:003557.12Department of AeronauticsElectric Propulsion (EP) technologies proved capable of significant performance improvements over traditional chemical systems and, consequently, made great technological and commercial progress over the past decades, with applications to geostationary satellites, exploration missions, and low Earth orbit satellite constellations [1]. Air-breathing electric propulsion may represent a disruptive approach to open new mission scenarios. From very-low Earth orbits to the deep space, the use of an electric power source to accelerate a propellant and generate thrust poses several scientific and technological challenges [2]. On-ground testing is one of the most complex tasks in developing plasma thrusters, requiring a representative environment and ad-hoc diagnostics. Recreating a representative environment is even more complex in the case of air-breathing electric propulsion, in which we need to generate a flow of atmospheric particles moving toward the spacecraft at almost 8 km/s. Modelling and simulations are then fundamental to investigate processes, as the particle collection or the plasma acceleration, that can be significantly affected by the limits of ground testing. Understanding the physics behind the operation of plasma thrusters can help improving their performance and reducing the complexities of space qualification. Open areas of research concern the characterization of anomalous transport and of discharge oscillations [3], which hinder the implementation of self-consistent and predictive models. At the same time, specific experimental activities and diagnostics shall be designed to validate the models and the numerical codes. In this talk, I will present the activities performed at SITAEL on plasma thrusters and air-breathing EP, focusing on the development and testing challenges, as well as on modelling and simulations.https://cassyni-user-files-prod.s3.amazonaws.com/MHXJgrqoJ6wzEFUeRDfHTC https://cassyni.com/events/TWRKAi5egsSLLSMaibUZ7j/seminar/qa https://cassyni.com/slides/outline/TWRKAi5egsSLLSMaibUZ7j https://cassyni.com/events/TWRKAi5egsSLLSMaibUZ7j/abstract https://cassyni-user-files-prod.s3.amazonaws.com/MEvPgzCaC5JekNuAdAQ18a https://cassyni.com/events/TWRKAi5egsSLLSMaibUZ7j?videoPreview=1 PyFR: Current Capabilities and Future Roadmapnohttps://cassyni.com/events/TWRKAi5egsSLLSMaibUZ7j?videoPreview=12021-03-24T15:00:00+00:003464.52PyFRHigh-order numerical methods for unstructured grids combine the superior accuracy of high-order spectral or finite difference methods with the geometrical flexibility of low-order finite volume or finite element schemes. The Flux Reconstruction (FR) approach unifies various high-order schemes for unstructured grids within a single framework. Additionally, the FR approach exhibits a significant degree of element locality, and is thus able to run efficiently on modern many-core hardware platforms, such as graphics processing units. Consequently, FR offers a promising route to performing affordable, and hence industrially relevant, scale-resolving simulations of hitherto intractable unsteady flows within the vicinity of real-world engineering geometries. In this talk I will review the current capabilities of PyFR, a high-order accurate computational fluids dynamics solver based on the FR approach. I will also present scale-resolving simulation results from a range of test cases, and outline our roadmap for future development of the solver.https://cassyni-user-files-prod.s3.amazonaws.com/MEvPgzCaC5JekNuAdAQ18a https://cassyni.com/slides/outline/4ni1VnP47FfgT9ckLdyfN5 https://cassyni.com/events/4ni1VnP47FfgT9ckLdyfN5/abstract https://cassyni-user-files-prod.s3.amazonaws.com/AyQfsVti3BUcysE7m9i8Kg https://cassyni.com/events/4ni1VnP47FfgT9ckLdyfN5?videoPreview=1 A Multiresolution Adaptive Wavelet Method for Nonlinear Partial Differential Equationsnohttps://cassyni.com/events/4ni1VnP47FfgT9ckLdyfN5?videoPreview=12022-03-21T15:00:00+00:003457.08Journal of Computational PhysicsModern computational science and engineering applications are inherently multiphysics and multiscale. Therefore, novel algorithms are required to solve partial differential equations (PDEs) with features evolving on a wide range of spatial and temporal scales. In this work, we propose a wavelet-based method which is ideally suited for problems developing localized structures, which might occur intermittently anywhere in the computational domain, or change their locations and scales in space and time. Wavelet-based numerical methods have been shown to be efficient for modeling multiscale and multiphysics problems because they provide spatial adaptivity through the use of multiresolution basis functions. In our work, we develop the Multiresolution Wavelet Toolkit (MRWT) that requires far fewer unknowns than other algorithms when applied to problems with a great range of spatial and temporal scales. In addition, the computational grid can be refined locally and our a priori error estimates safeguard the accuracy of the numerical solution. MRWT is designed to execute in a hybrid CPU/GPU environment and scale to ~10^3-10^4 cores. Consequently, MRWT provides high fidelity simulations with significant data compression. We explain how this technique uses differentiable wavelet basis functions and second-generation wavelets, to solve nonlinear PDEs on finite domains. Moreover, we provide a priori error estimates for the wavelet representation of fields, their derivatives, and the aliasing errors associated with the nonlinear terms in PDEs. Then, by projecting fields and spatial derivative operators onto the wavelet basis, our estimates are used to construct a sparse multiresolution spatial discretization which guarantees the prescribed accuracy for each field. Additionally, MRWT utilizes a predictor-corrector procedure within the time advancement loop to dynamically adapt the computational grid, maintaining the prescribed accuracy of the solutions of the PDEs as they evolve. We show verification of the MRWT algorithm, demonstrating mathematical correctness and physics simulation capabilities. Furthermore, spatial convergence is achieved at a rate which agrees with a priori estimates. Finally, we apply MRWT to problems with shocks in gasses and to high-strain rate damage nucleation and propagation in nonlinear solids.https://cassyni-user-files-prod.s3.amazonaws.com/AyQfsVti3BUcysE7m9i8Kg https://cassyni.com/slides/outline/4o8MDE7M9fZaeK4mdA4HqP https://cassyni.com/events/4o8MDE7M9fZaeK4mdA4HqP/abstract https://cassyni-user-files-prod.s3.amazonaws.com/4aqi8qJiKmtLT3w9D57kbp https://cassyni.com/events/4o8MDE7M9fZaeK4mdA4HqP?videoPreview=1 Climate Geroscience: The Case for “Wisdom-Inquiry” Sciencenohttps://cassyni.com/events/4o8MDE7M9fZaeK4mdA4HqP?videoPreview=12024-11-08T12:00:00+00:002495.16Royal Society PublishingWhy should, and how can, the fields of climate science and geroscience (which studies the biology of aging) facilitate the cross-disciplinary collaboration needed to ensure that human and planetary health are both promoted in the future of an older, and warmer, world? Appealing to the ideal of “wisdom-oriented” science (Maxwell 1984), where scientists consider themselves to be artisans working for the public good, a number of the real-world epistemic constrains on the scientific enterprise are identified. These include communicative frames that stoke intergenerational conflict (rather than solidarity) and treat the ends of planetary and human health as independent “sacred values”(Tetlock 2003) rather than as interdependent ends. To foster “climate geroscience”— the field of knowledge and translational science at the intersection of climate science and geroscience— researchers in both fields are encouraged to think of novel ways they could make researchers from the other field “conversationally” present when framing the aspirations of their respective fields, applying for grant funding, and designing their conferences and managing their scientific journals. https://cassyni-user-files-prod.s3.amazonaws.com/4aqi8qJiKmtLT3w9D57kbp https://cassyni.com/slides/outline/FeyJWpcbmKr9yRSmxBDMJu https://cassyni.com/events/FeyJWpcbmKr9yRSmxBDMJu/abstract https://cassyni-user-files-prod.s3.amazonaws.com/6PXQaXcH8bsvWPhZmyKWSJ https://cassyni.com/events/FeyJWpcbmKr9yRSmxBDMJu?videoPreview=1 LALS Staff Seminarnohttps://cassyni.com/events/FeyJWpcbmKr9yRSmxBDMJu?videoPreview=12022-04-01T03:00:00+00:002994.28Linguistics and Applied Language StudiesA greatest-hits, whirlwind tour of highlights from LALS staff who have only two minutes to talk about their recent research! You’ve heard of three-minute thesis, but what happens after you graduate? Apparently, you lose a whole minute. Kick off the new trimester by getting to know academic staff from the School of Linguistics and Applied Language studies a bit better. In this seminar, staff in the School will each discuss some of their current research. However, there is a catch! Each staff member is limited to two presentation slides and a total presentation time of two minutes. Come watch them efficiently and expertly explain their research! You’ll gain a better understanding of the breadth and wealth of the research being performed by members of the School of Linguistics and Applied Language studies. https://cassyni-user-files-prod.s3.amazonaws.com/6PXQaXcH8bsvWPhZmyKWSJ https://cassyni.com/slides/outline/Wy8HBGheBEsNvXBcxbzDwj https://cassyni.com/events/Wy8HBGheBEsNvXBcxbzDwj/abstract https://cassyni-user-files-prod.s3.amazonaws.com/X4hXRW14HUFvQxx1C1v4CE https://cassyni.com/events/Wy8HBGheBEsNvXBcxbzDwj?videoPreview=1 Maze balls and phoxonic metamaterialsnohttps://cassyni.com/events/Wy8HBGheBEsNvXBcxbzDwj?videoPreview=12022-07-26T16:00:00+00:005887.0MetaMATControlling sound or light with metamaterials is a booming and illuminating field of research. Here we present two studies involving metamaterial structures. In the first study we propose an octagonal onion-like structure with interconnected labyrinthine shells that can reflect sub-kHz airborne sound when placed inside a cylindrical tube. The structure, fabricated by 3D printing, is found to stop 67% of the incident sound on resonance with a volume filling fraction of only 13%. In the second study we propose a new kind of metamaterial that is simultaneously acoustic and electromagnetic, which may have use as a new kind of wave modulator. Our design, verified by numerical simulation, is demonstrated in the audio acoustic and microwave electromagnetic range. https://cassyni-user-files-prod.s3.amazonaws.com/X4hXRW14HUFvQxx1C1v4CE https://cassyni.com/slides/outline/R3KQWSRTWPJUiBwsZasTn5 https://cassyni.com/events/R3KQWSRTWPJUiBwsZasTn5/abstract https://cassyni-user-files-prod.s3.amazonaws.com/yYz1jJfT2vgex3oV6FNAa https://cassyni.com/events/R3KQWSRTWPJUiBwsZasTn5?videoPreview=1 Spectroscopic assessment of the influence of copper loading and gamma-ray irradiation on calcium phosphate bio-relevant glassesnohttps://cassyni.com/events/R3KQWSRTWPJUiBwsZasTn5?videoPreview=12022-05-23T14:00:00+00:002768.56Chemical Physics ImpactCalcium phosphate glasses containing copper possess antimicrobial properties and thus have attracted attention for biomedical applications such as tissue engineering [1]. Still, studies incorporating structural, thermal, and optical property evaluations in connection with the oxidation states of copper are scarce. In this work, a comprehensive evaluation was carried out on biologically relevant P2O5-CaO-Na2O-CuO glasses prepared with variable [CuO]/[Na2O] molar ratios by the melt-quenching technique [2]. A structural evaluation was first performed by X-ray diffraction to confirm amorphous nature and Fourier transform-infrared (FT-IR) spectroscopy to obtain information about phosphate network characteristics. The thermal properties were then assessed by dilatometry evaluating thermal expansion profiles, followed by differential scanning calorimetry (DSC) in the glass transition regime. The optical transmission from the ultraviolet (UV) to the near-infrared (NIR) region was then scrutinized in the context of solid-state physics through Tauc plots (optical band gap analysis) and Urbach plots (band tailing reflecting disorder). The optical appraisal was complemented by photoluminescence (PL) spectroscopy with emission decay analysis where appropriate. X-ray photoelectron spectroscopy (XPS) was ultimately employed to probe oxygen environments and perform Cu+/Cu2+ speciation for further connection with the evaluated properties. In a subsequent stage, the impact of gamma-ray irradiation was assessed for the various glasses through optical transmission and PL spectroscopy [3].https://cassyni-user-files-prod.s3.amazonaws.com/yYz1jJfT2vgex3oV6FNAa https://cassyni.com/slides/outline/TWZRjrf5hg4y58RS7Gn6W1 https://cassyni.com/events/TWZRjrf5hg4y58RS7Gn6W1/abstract https://cassyni-user-files-prod.s3.amazonaws.com/GS283NyXBeHoCUSPYbPxXg https://cassyni.com/events/TWZRjrf5hg4y58RS7Gn6W1?videoPreview=1 An Allowable Feast: A tour of the work of Eli Goodman and Ricky Pollacknohttps://cassyni.com/events/TWZRjrf5hg4y58RS7Gn6W1?videoPreview=12022-04-12T16:40:00+00:001691.04Discrete & Computational GeometryNo abstracthttps://cassyni-user-files-prod.s3.amazonaws.com/GS283NyXBeHoCUSPYbPxXg https://cassyni.com/slides/outline/ADsH7w1iLegrQFfAYw3jEM https://cassyni.com/events/ADsH7w1iLegrQFfAYw3jEM/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Ch4TJGBf9Pd8bKGYRN1Dwc https://cassyni.com/events/ADsH7w1iLegrQFfAYw3jEM?videoPreview=1 Decolonizing “Natural Logic”nohttps://cassyni.com/events/ADsH7w1iLegrQFfAYw3jEM?videoPreview=12021-12-15T11:40:00+00:004949.32Logica Universalis“Natural logic” was proposed by Lewis Henry Morgan (1818–1881) as the engine of cultural evolution, concluding that the “course and manner” of cultural development “was predetermined, as well as restricted within narrow limits of divergence, by the natural logic of the human mind.” This essay argues that Morgan’s conception of natural logic aids the project of settler colonialism. Rather than being a false account of human agency, however, it is a conception of natural logic that is produced through the systematic narrowing of possibilities for agency, human, and otherwise. This narrowed logic is thus only a part of a differently conceived logic of agency that is also general (and so serves as the framework for all action) and normative (albeit with a set of norms different from those identified by Morgan). The discussion proceeds in four sections: first, a presentation of Morgan’s conception of natural logic and its origins; second, an analysis of four colonizing implications of Morgan’s view; third, examples of further developments of natural logic in the twentieth and twenty-first centuries in the work structuralist and post-structuralist theorists; and, last, a brief introduction of a decolonial logic that provides a broader alternative conception of the structure of agency, human, and otherwise, and that avoids the oppressive effects of the reductionism of the natural logic received from Morgan and his successors.https://cassyni-user-files-prod.s3.amazonaws.com/Ch4TJGBf9Pd8bKGYRN1Dwc https://cassyni.com/slides/outline/M6ACFbm9Q5o451BbT3Droo https://cassyni.com/events/M6ACFbm9Q5o451BbT3Droo/abstract https://cassyni-user-files-prod.s3.amazonaws.com/VE3whZkev77uEL1jKKA86z https://cassyni.com/events/M6ACFbm9Q5o451BbT3Droo?videoPreview=1 Games and Graphics in Unreal Engine 5 - teaching from within the Game Engine.nohttps://cassyni.com/events/M6ACFbm9Q5o451BbT3Droo?videoPreview=12022-09-07T03:00:00+00:003548.96Computer Graphics GroupThis presentation will discuss the use of Unreal Engine in the revamped Graphics and Games degree. This will show the use of VR mode for first-person editing in VR and the combination with multi-user editing which allows the lecturer to talk to the students from within the game they are developing inside the editor. The ability to edit and discuss the visuals of a game from within the game while others are editing and controlling the game world is a new style of interaction. We will also discuss the use of GitHub co-pilot in Visual Studio while working in the Unreal Engine. What are the benefits and challenges of AI-supported game development?https://cassyni-user-files-prod.s3.amazonaws.com/VE3whZkev77uEL1jKKA86z https://cassyni.com/events/L6rzAEU6XAguQFMbM4kXzu/seminar/qa https://cassyni.com/slides/outline/L6rzAEU6XAguQFMbM4kXzu https://cassyni.com/events/L6rzAEU6XAguQFMbM4kXzu/abstract https://cassyni-user-files-prod.s3.amazonaws.com/EgiP1B48hZ8yTK9YUs9Hdx https://cassyni.com/events/L6rzAEU6XAguQFMbM4kXzu?videoPreview=1 DScribe: Library of descriptors for machine learning in materials sciencenohttps://cassyni.com/events/L6rzAEU6XAguQFMbM4kXzu?videoPreview=12022-09-13T15:00:00+00:003506.32Computer Physics CommunicationsThis talk introduces DScribe which is a Python package for transforming atomic structures into fixed-size numerical fingerprints. These fingerprints are often called "descriptors" and they can be used in various tasks, including machine learning, visualization, similarity analysis, etc. DScribe provides user-friendly, off-the-shelf descriptor implementations and is freely available under the open-source Apache License 2.0. This seminar will include several hands-on examples on how these descriptors can be used for different tasks, including property prediction through a regression model, data clustering through unsupervised learning, and visualization of complex chemical environments. The package currently contains implementations for Coulomb matrix, Ewald sum matrix, sine matrix, Smooth Overlap of Atomic Positions (SOAP), Many-body Tensor Representation (MBTR), Local Many-body Tensor Representation (LMBTR), Atom-centered Symmetry Function (ACSF) and the Valle-Oganov descriptor. https://cassyni-user-files-prod.s3.amazonaws.com/EgiP1B48hZ8yTK9YUs9Hdx https://cassyni.com/slides/outline/DgQWSiYPQrZVRwxjCbRgmB https://cassyni.com/events/DgQWSiYPQrZVRwxjCbRgmB/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Dz7t3hDmLcZKgX5MyDttSJ https://cassyni.com/events/DgQWSiYPQrZVRwxjCbRgmB?videoPreview=1 Corporate Environmental Investment and Firm Value: The Moderating Effects of Organisational Visibility and Environmental Reportingnohttps://cassyni.com/events/DgQWSiYPQrZVRwxjCbRgmB?videoPreview=12022-09-21T01:30:00+00:004365.72SACLABSTRACT As environmental concerns in China grow there is increasing emphasis on the role business investment plays in creating positive environmental outcomes. However, research on the economic consequence of corporate environmental investment in China remains limited. According to the literature on institutional studies, there are two important factors that are likely to influence a firm’s investment decision making: one is organisational visibility, an important company characteristic shaped by firm legitimacy pressures; another is environmental reporting, a key strategy a firm can use to legitimise its environmental efforts. Therefore, this paper examines how these factors influence the relationship between environmental investment and firm value. Based on a sample of 367 firm-years listed on the Shanghai stock exchange during the period 2016-2019, the regression results found that in the short term, higher levels of environmental investment were associated with lower firm value. However, higher levels of public attention (one dimension of organisational visibility) and monetary environmental reporting are associated with lower short-term negative effects of environmental investment on firm value. Further analyses show that for firms making large environmental investments, both dimensions of visibility (i.e., public attention and analyst coverage) and substantive emissions reporting are related to lower negative effects of environmental investment on firm value. This paper contributes to our understanding of the theoretical links between corporate environmental efforts and firm value creation. Specifically, both organisational visibility and environmental reporting can positively influence shareholders’ valuation of corporate environmental investment. This is particularly the case for firms making large environmental investments. These findings suggest that a firm’s substantive environmental reporting, or strategies that focus on improving organisational visibility, are useful relational strategies to enhance its shareholder management that in turn leverages shareholders’ evaluation in favour of this firm. Paper [here](https://web.tresorit.com/l/wkvGQ#wACHyHeG5GejEGf-Kp6Pag) https://cassyni-user-files-prod.s3.amazonaws.com/Dz7t3hDmLcZKgX5MyDttSJ https://cassyni.com/slides/outline/RXzdfkasMCnJXewPMgzRxH https://cassyni.com/events/RXzdfkasMCnJXewPMgzRxH/abstract https://cassyni-user-files-prod.s3.amazonaws.com/VB5waq8iDrvsixDZdX8x7G https://cassyni.com/events/RXzdfkasMCnJXewPMgzRxH?videoPreview=1 HAIM: Holistic AI for Medicinenohttps://cassyni.com/events/RXzdfkasMCnJXewPMgzRxH?videoPreview=12022-08-31T12:30:00+00:002972.64Artificial intelligence (AI) systems hold great promise to improve healthcare over the next decades. Specifically, AI systems leveraging multiple data sources and input modalities are poised to become a viable method to deliver more accurate results and deployable pipelines across a wide range of applications. In this work, we propose and evaluate a unified Holistic AI in Medicine (HAIM) framework to facilitate the generation and testing of AI systems that leverage multimodal inputs. Our approach uses generalizable data pre-processing and machine learning modeling stages that can be readily adapted for research and deployment in healthcare environments. We evaluate our HAIM framework by training and characterizing 14,324 independent models based on MIMIC-IV-MM, a multimodal clinical database (N=34,537 samples) containing 7,279 unique hospitalizations and 6,485 patients, spanning all possible input combinations of 4 data modalities (i.e., tabular, time-series, text, and images), 11 unique data sources and 12 predictive tasks. We show that this framework can consistently and robustly produce models that outperform similar single-source approaches across various healthcare demonstrations (by 6-33%), including 10 distinct chest pathology diagnoses, along with length-of-stay and 48-hour mortality predictions. We also quantify the contribution of each modality and data source using Shapley values, which demonstrates the heterogeneity in data modality importance and the necessity of multimodal inputs across different healthcare-relevant tasks. The generalizable properties and flexibility of our Holistic AI in Medicine (HAIM) framework could offer a promising pathway for future multimodal predictive systems in clinical and operational healthcare settings.https://cassyni-user-files-prod.s3.amazonaws.com/VB5waq8iDrvsixDZdX8x7G https://cassyni.com/slides/outline/3JnpUMxNCEw4uSfbBVUo5f https://cassyni.com/events/3JnpUMxNCEw4uSfbBVUo5f/abstract https://cassyni-user-files-prod.s3.amazonaws.com/8N7pmGCNtS6KCLt1p83cce https://cassyni.com/events/3JnpUMxNCEw4uSfbBVUo5f?videoPreview=1 Learn Together with the Teachers: Teacher Professional Development for Task-based Language Teaching (TBLT) in Rural Chinanohttps://cassyni.com/events/3JnpUMxNCEw4uSfbBVUo5f?videoPreview=12022-09-30T03:00:00+00:002946.0Linguistics and Applied Language StudiesThis talk reports on an EFL teacher professional development project for task-based language teaching (TBLT) at a rural secondary school in North-western China. The research adopted a reflective narrative approach to explore the researcher’s experience of working alongside teachers in the school in adapting the textbook to strengthen the communicativeness and task-likeness of the lessons. The findings challenge assumptions about the capabilities of teachers and learners in rural environments and about the suitability of TBLT in such contexts. https://cassyni-user-files-prod.s3.amazonaws.com/8N7pmGCNtS6KCLt1p83cce https://cassyni.com/events/P59L39Zenxycoe7fV969pq/abstract https://cassyni-user-files-prod.s3.amazonaws.com/L8q74Fe7hYxAfPtsR5b8Tp https://cassyni.com/slides/outline/PZpZCTj4dnTSd77BHFD813 https://cassyni.com/events/PZpZCTj4dnTSd77BHFD813/abstract https://cassyni-user-files-prod.s3.amazonaws.com/MmqdPfvpHTG7awAzjdYnPx https://cassyni.com/events/PZpZCTj4dnTSd77BHFD813?videoPreview=1 CUBENS: A GPU-accelerated high-order solver for wall-bounded flows with non-ideal fluidsnohttps://cassyni.com/events/PZpZCTj4dnTSd77BHFD813?videoPreview=12025-02-20T17:00:00+00:002071.24Computer Physics CommunicationsWe present a massively parallel GPU-accelerated solver for direct numerical simulations of transitional and turbulent flat-plate boundary layers and channel flows involving fluids in non-ideal thermodynamic states. While several high-fidelity solvers are currently available as open source, all of them are restricted to the ideal-gas region. In contrast, the CUBic Equation of state Navier-Stokes solver (CUBENS) can accurately model and simulate the non-ideal thermodynamics of single-phase compressible fluids in the vicinity of the vapor-liquid saturation line or the thermodynamic critical point. By employing high-order finite-difference schemes and convective terms in split, kinetic-energy-, and entropy-preserving form, the solver is numerically stable, and robust with minimal numerical dissipation, enabling it to capture the steep variations of non-ideal thermodynamic properties. For cost-effective high-fidelity simulations, in addition to MPI parallelization, CUBENS is GPU-accelerated using OpenACC directives for computation offloading, and asynchronous GPU-aware MPI for efficient GPU-GPU communication. Moreover, CUBENS is compatible with both NVIDIA and AMD GPU architectures, achieving significant performance results while ensuring energy-efficient simulations. For instance, using 64 NVIDIA A100 GPUs compared to 8192 CPUs at the same computational cost results in a speedup of approximately $130 \times$. In multi-node and multi-GPU configurations ranging from 2 to 128 compute nodes (8 to 512 GPUs), a strong scaling efficiency of around 52\% and a weak scaling efficiency of 0.88 with $1024^3$ points per GPU, corresponding to approximately $5$ billion degrees of freedom, are achieved. The CUBENS solver is validated against selected cases from the literature, covering transitional to turbulent ideal and non-ideal flows up to the transonic regime. In particular, we demonstrate the solver's suitability and applicability for direct numerical simulations of transitional boundary layers with fluids at supercritical pressure and with buoyancy effects. The development of this high-fidelity solver offers the potential for future fundamental research in non-ideal compressible fluid dynamics. https://cassyni-user-files-prod.s3.amazonaws.com/MmqdPfvpHTG7awAzjdYnPx https://cassyni.com/slides/outline/GA6VWD2C3v9eokLwEUF7sK https://cassyni.com/events/GA6VWD2C3v9eokLwEUF7sK/abstract https://cassyni-user-files-prod.s3.amazonaws.com/DXxsU5cdqYL3HbKbrsfh4a https://cassyni.com/events/GA6VWD2C3v9eokLwEUF7sK?videoPreview=1 Bin Chicken: targeted metagenomic coassembly for the efficient recovery of novel genomesnohttps://cassyni.com/events/GA6VWD2C3v9eokLwEUF7sK?videoPreview=12025-02-17T11:00:00+00:00708.48Microbiome Virtual International ForumRecovery of microbial genomes from metagenomic datasets has provided genomic representation for hundreds of thousands of species from diverse biomes. However, low abundance microorganisms are often missed due to insufficient genomic coverage. Here we present Bin Chicken, an algorithm which substantially improves genome recovery through automated, targeted selection of metagenomes for coassembly based on shared marker gene sequences derived from raw reads. Marker gene sequences that are divergent from known reference genomes can be further prioritised, providing an efficient means of recovering highly novel genomes. Applying Bin Chicken to public metagenomes and coassembling 800 sample-groups recovered 77,562 microbial genomes, including the first genomic representatives of 6 phyla, 41 classes, and 24,028 species. These genomes expand the genomic tree of life and uncover a wealth of novel microbial lineages for further research.https://cassyni-user-files-prod.s3.amazonaws.com/DXxsU5cdqYL3HbKbrsfh4a https://cassyni.com/events/WyYctiRwDemH7gdeF84rR3/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Gcw7SfETmjTMbidCfpZ8vr https://cassyni.com/events/AixqzguRDt4aQt6hdZFKss/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Gwhnnea47M6PmHqC84iuRg https://cassyni.com/events/XUDr42bM4UF6w9dA3EBpbF/abstract https://cassyni-user-files-prod.s3.amazonaws.com/EU7nmrVTPoZ4RYBMErEHKL https://cassyni.com/events/Q45SeLABSC3QvKq3k6Xrm3/seminar/qa https://cassyni.com/slides/outline/Q45SeLABSC3QvKq3k6Xrm3 https://cassyni.com/events/Q45SeLABSC3QvKq3k6Xrm3/abstract https://cassyni-user-files-prod.s3.amazonaws.com/TPxJV5RqGZM7mVLzZDu6nS https://cassyni.com/events/Q45SeLABSC3QvKq3k6Xrm3?videoPreview=1 Viral diversity in the human microbiomenohttps://cassyni.com/events/Q45SeLABSC3QvKq3k6Xrm3?videoPreview=12025-09-09T15:00:00+00:00727.28Microbiome Virtual International ForumThe number of viral particles on Earth outnumber other microbes by an order of magnitude, and the same holds true in the human microbiome. The human-associated virome is typically dominated by phage, which have historically been difficult to identify via either culture or metagenomics. With the launch of the Human Virome Program, a range of new computational and experimental methods are being developed and applied to large populations to establish an improved baseline for virome diversity. I will discuss the HVP as a program, as well as an early look at improved methods for viral profiling from metagenomes and metatranscriptomes, along with their application to identify ecological and individual viral associations with conditions including the inflammatory bowel diseases and colorectal cancer.https://cassyni-user-files-prod.s3.amazonaws.com/TPxJV5RqGZM7mVLzZDu6nS https://cassyni.com/slides/outline/Jcwo8p3Qc9xLXTap9BY4mb https://cassyni.com/events/Jcwo8p3Qc9xLXTap9BY4mb/abstract https://cassyni-user-files-prod.s3.amazonaws.com/W9PjHD383DXmPw3ytTPqXc https://cassyni.com/events/Jcwo8p3Qc9xLXTap9BY4mb?videoPreview=1 Spider Venom Potency Exhibits Phylogenetic Prey Specificity but Does Not Trade-off With Body Size or Silk Use in Prey Capturenohttps://cassyni.com/events/Jcwo8p3Qc9xLXTap9BY4mb?videoPreview=12025-05-12T19:00:00+00:001437.12Royal Society PublishingSpiders employ a diverse range of predator traits including potent venoms, complex silk hunting strategies and mechanical strength coupled with larger body sizes to capture prey. This trait diversity, along with the quantifiable nature of venom potency, makes spiders an excellent group to study evolutionary trade-offs. Yet, comparative approaches have been historically confounded by the use of atypical prey models to measure venom potency. Here, we account for such confounding issues by incorporating the phylogenetic similarity between a spider's diet and the species used to measure its venom potency. Using a phylogenetic comparative analysis of 75 spider species to test how diet, silk use in prey capture and body size drive venom yield and potency (LD50), we show that spider venoms are generally more potent against prey models more closely related to their natural prey, reflecting prey-specific patterns. Despite predictions, we find no trade-offs between body size, silk use in prey capture and venom potency. We also find that venom yield scales sublinearly with size, reflecting the 0.75 allometric scaling predicted by metabolic theory, suggesting venom is metabolically expensive in spiders. Our approach demonstrates how contemporary comparative approaches can be applied to historic venom potency measures to test fundamental evolutionary patterns in predator traits.https://cassyni-user-files-prod.s3.amazonaws.com/W9PjHD383DXmPw3ytTPqXc https://cassyni.com/events/4npVxJSbihNb2kpWX586fP/abstract https://cassyni-user-files-prod.s3.amazonaws.com/NoN5YMaPEZrHidKdK87Mvn https://cassyni.com/events/P4qUnDtuMzndC5sQP49xeq/abstract https://cassyni-user-files-prod.s3.amazonaws.com/BFbNG4YJFTMykvkiVYJxvA https://cassyni.com/events/WxB7HsBWUyNfurqDYbCYfF/abstract https://cassyni-user-files-prod.s3.amazonaws.com/ACuu7iGU33cjzuZs2vFZ7c https://cassyni.com/slides/outline/J7M2CiskURuXr7X9BUBCAh https://cassyni.com/events/J7M2CiskURuXr7X9BUBCAh/abstract https://cassyni-user-files-prod.s3.amazonaws.com/XwqRFaTJxMnwwZnc4SdFdp https://cassyni.com/events/J7M2CiskURuXr7X9BUBCAh?videoPreview=1 Efficient sequence alignment against millions of prokaryotic genomes with LexicMapnohttps://cassyni.com/events/J7M2CiskURuXr7X9BUBCAh?videoPreview=12025-12-10T02:00:00+00:00791.32Microbiome Virtual International ForumThe size of microbial sequence databases continues to grow far beyond the abilities of existing alignment tools. We introduce LexicMap, a nucleotide sequence alignment tool for efficiently querying moderate length sequences (>250 bp) such as a gene, plasmid or long read against up to millions of prokaryotic genomes. We construct a small set of probe k-mers which are selected to efficiently sample the entire database to be indexed, such that every 250 bp window of each database genome contains multiple seed k-mers each with a shared prefix with one of the probes. Storing these seeds in a hierarchical index enables fast and low-memory alignment. We benchmark both accuracy and potential to scale to databases of millions of bacterial genomes, showing that LexicMap achieves comparable accuracy with state-of-the-art, but with greater speed and lower memory use. Our method supports querying at scale and within minutes, which will be useful for many biological applications across epidemiology, ecology and evolution. LexicMap produces output in standard formats including that of BLAST and is available under MIT license at https://github.com/shenwei356/LexicMap.https://cassyni-user-files-prod.s3.amazonaws.com/XwqRFaTJxMnwwZnc4SdFdp https://cassyni.com/events/XSYVCFgAtpfW7maUEcPKfT/seminar/qa https://cassyni.com/slides/outline/XSYVCFgAtpfW7maUEcPKfT https://cassyni.com/events/XSYVCFgAtpfW7maUEcPKfT/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Xy1DqGTJLSRr31NPtPkoYi https://cassyni.com/events/XSYVCFgAtpfW7maUEcPKfT?videoPreview=1 Integrative Perspectives on Suicide: From Mechanisms to Meaningful Interventionnohttps://cassyni.com/events/XSYVCFgAtpfW7maUEcPKfT?videoPreview=12026-07-02T17:00:00+00:003334.96MultiPsych JournalWe are delighted to launch our third special issue on 'Integrative Perspectives on Suicide: From Mechanisms to Meaningful Intervention' hosted by guest editors and editorial board member Emeritus Professor Andrew Reeves and Dr Amanda McGarry from the University of Chester. The aim of this special issue is to: 1. Illuminate multi level mechanisms underlying suicidal ideation and behaviour- We aim to showcase research examining how psychological, biological, relational, sociocultural, and environmental factors interact to shape suicidality. This includes emerging evidence on mechanism-focused therapy, ideation-to-action processes, and newer theoretical models such as evolutionary or cross-cultural perspectives. 2. Bridge mechanism of science and meaningful intervention - A core aim is to highlight interventions—clinical, community-based, educational, digital, or policy-level—that explicitly draw on mechanistic understanding (e.g., emotional dysregulation, cognitive biases, interpersonal pain). We welcome evidence-based and innovative approaches, including multi-component or integrative programs, consistent with recent trends in suicide-prevention research. 3. Address real-world implementation challenges and facilitators - Given the documented barriers to implementing complex suicide-prevention interventions (stakeholder engagement, cultural fit, resource limitations, system constraints), the issue invites research exploring implementation science, service design, and practical adaptations necessary for effective delivery. 4. Highlight contextual and societal determinants of suicide - Following public health frameworks, we aim to include work on structural drivers such as access to means, economic instability, inequalities, and community-level risk and protective factors—domains shown to play critical roles in shaping suicide rates and intervention impact. 5. Integrate lived-experience perspectives and user-informed models - Consistent with contemporary calls for co-designed and user-centred suicide-prevention strategies, the special issue will prioritise contributions that incorporate lived experience, community voices, and participatory approaches, which have been shown to strengthen relevance, ethics, and intervention uptake. 6. Promote cross-disciplinary synthesis and future directions - Finally, the issue aims to encourage conceptual integration, proposing new frameworks or theoretical bridges that unify knowledge across psychology, psychotherapy, psychiatry, public health, sociology, and related fields—moving the field toward comprehensive, mechanistically grounded, and scalable solutions. https://cassyni-user-files-prod.s3.amazonaws.com/Xy1DqGTJLSRr31NPtPkoYi https://cassyni.com/slides/outline/YRnT4MwSy1vHr1Y7bemDmf https://cassyni.com/events/YRnT4MwSy1vHr1Y7bemDmf/abstract https://cassyni.com/events/YRnT4MwSy1vHr1Y7bemDmf?videoPreview=1 Ecological selectivity of diet on turtle K/Pg survivorshipnohttps://cassyni.com/events/YRnT4MwSy1vHr1Y7bemDmf?videoPreview=12026-03-24T11:00:00+00:00675.52Royal Society PublishingThe Cretaceous/Palaeogene (K/Pg) mass extinction was catastrophic, eliminating much of terrestrial life and entire iconic vertebrate groups, such as non-avian dinosaurs and many large marine reptiles. Turtles, however, were one of the less affected reptilian groups, persisting into the Cenozoic with minimal diversity loss. Diet has been suggested to explain high turtle survivorship, as multiple K/Pg survivors exhibit durophagous adaptations, but this has never been properly tested. We use phylogenetic comparative methods to map durophagy across turtle evolution and statistically test a relationship between turtle survivorship and durophagy. Turtles evolved durophagy multiple times over the course of their history, and our results indicate that the number of durophage lineages was more stable across the K/Pg transition than that of non-durophages. Additionally, our findings show that durophagy is positively correlated with turtle K/Pg survivorship, whereby durophagous species exhibit higher predicted survival probabilities. As non-durophagous turtle lineages also survive, albeit with lower probability, other factors might also influence turtle survivorship. Overall, this study provides numerical evidence for dietary ecological selectivity among turtle survivors at the end-Cretaceous crisis. Future taxonomic assessments of the turtle fossil record around the K/Pg boundary will be key to refine these results. https://cassyni.com/events/Gd6MokGRj63soqHmDxZb7j/abstract https://cassyni-user-files-prod.s3.amazonaws.com/2ECKsBMqXQSFvvZqfhTqCJ https://cassyni.com/slides/outline/EeXZjeCDNcmDGfPZSDPFoB https://cassyni.com/events/EeXZjeCDNcmDGfPZSDPFoB/abstract https://cassyni-user-files-prod.s3.amazonaws.com/12xUZvi7Zy8jTWPBGhjr4W https://cassyni.com/events/EeXZjeCDNcmDGfPZSDPFoB?videoPreview=1 Diet, the microbiome and solid tumor treatment response: State of the evidencenohttps://cassyni.com/events/EeXZjeCDNcmDGfPZSDPFoB?videoPreview=12026-09-17T00:30:00+00:001256.92Microbiome Virtual International ForumThe gut microbiome is a critical determinant of response, resistance, and toxicity to immune checkpoint inhibitors (ICI), and diet represents one of the most powerful and modifiable influences on microbial composition and function. This talk reviews the current state of evidence linking dietary patterns and specific dietary components to immunotherapy outcomes in solid tumors — from preclinical data establishing mechanistic links between diet, pro-ICI microbial taxa, and microbiome-derived metabolites, to observational and interventional clinical data from trials testing high-fiber and prebiotic dietary strategies in patients undergoing immunotherapy. The functional consequences of diet-driven shifts in microbiome composition, including changes in microbial metabolite output and immune crosstalk, will be highlighted as key mediators of treatment response.https://cassyni-user-files-prod.s3.amazonaws.com/12xUZvi7Zy8jTWPBGhjr4W https://cassyni.com/slides/outline/JcJUWLC2Lred83tpsR5FRw https://cassyni.com/events/JcJUWLC2Lred83tpsR5FRw/abstract https://cassyni-user-files-prod.s3.amazonaws.com/3kYvSKHPPM6zoVbf6gq1ze https://cassyni.com/events/JcJUWLC2Lred83tpsR5FRw?videoPreview=1 Regulatory Pathways for Medical Foodsnohttps://cassyni.com/events/JcJUWLC2Lred83tpsR5FRw?videoPreview=12026-09-17T01:15:00+00:00893.6Microbiome Virtual International ForumNavigating the regulatory landscape for medical foods in the United States presents substantial challenges due to narrow statutory definitions and stringent FDA interpretations. Originating from the Orphan Drug Act, medical foods are formulated for enteral consumption under physician supervision, specifically intended for the dietary management of a disease or condition with distinctive nutritional requirements established by medical evaluation. A primary hurdle for developers is demonstrating that the target condition creates unique nutritional needs that cannot be met through normal dietary modification alone. General wellness claims, digestive comfort, or broad microbiome support are insufficient unless directly tied to a recognized nutritional requirement. Furthermore, positioning products to treat, mitigate, or alter disease progression elevates regulatory risk and can lead to reclassification as a drug. Consequently, claims, evidence, endpoints, and promotional materials must strictly reinforce a narrow dietary management position. Once product positioning is established, developers must ensure that ingredients possess a valid regulatory basis for use, as medical foods do not undergo a pre-market FDA approval process. Most successful strategies rely on Generally Recognized as Safe determinations. For novel or modified sources, companies must establish a new determination rather than relying on prior conclusions. While self-assessments utilize an independent panel of experts to reach safety consensus, companies also evaluate voluntary notifications to the FDA, noting that a proposed rule published in August could alter future submission requirements. Additional commercialization pathways include new dietary ingredient notifications, which are increasingly utilized for ingredients produced through emerging technologies such as fermentation.https://cassyni-user-files-prod.s3.amazonaws.com/3kYvSKHPPM6zoVbf6gq1ze https://cassyni.com/slides/outline/FAQZp2WjXx5EjZf2LWEpS1 https://cassyni.com/events/FAQZp2WjXx5EjZf2LWEpS1/abstract https://cassyni-user-files-prod.s3.amazonaws.com/JEPryfMfaSfA5GCRYXfVcJ https://cassyni.com/events/FAQZp2WjXx5EjZf2LWEpS1?videoPreview=1 TaxSEA: rapid interpretation of microbiome alterations using taxon set enrichment analysis and public databasesnohttps://cassyni.com/events/FAQZp2WjXx5EjZf2LWEpS1?videoPreview=12025-06-03T14:00:00+00:00542.28Microbiome Virtual International ForumMicrobial communities are essential regulators of ecosystem function, with their composition commonly assessed through DNA sequencing. Most current tools focus on detecting changes among individual taxa (e.g. species or genera), however in other omics fields, such as transcriptomics, enrichment analyses like gene set enrichment analysis are commonly used to uncover patterns not seen with individual features. Here, we introduce TaxSEA, a taxon set enrichment analysis tool available as an R package, a web portal (https://shiny.taxsea.app), and a Python package. TaxSEA integrates taxon sets from five public microbiota databases (BugSigDB, MiMeDB, GutMGene, mBodyMap, and GMRepoV2) while also allowing users to incorporate custom sets such as taxonomic groupings. In silico assessments show TaxSEA is accurate across a range of set sizes. When applied to differential abundance analysis output from inflammatory bowel disease and type 2 diabetes metagenomic data, TaxSEA can rapidly identify changes in functional groups corresponding to known associations. We also show that TaxSEA is robust to the choice of differential abundance analysis package. In summary, TaxSEA enables researchers to efficiently contextualize their findings within the broader microbiome literature, facilitating rapid interpretation, and advancing understanding of microbiome-host and environmental interactions.https://cassyni-user-files-prod.s3.amazonaws.com/JEPryfMfaSfA5GCRYXfVcJ https://cassyni.com/events/QYkfoeKbH1XEjnpZYCepwF/seminar/qa https://cassyni.com/slides/outline/QYkfoeKbH1XEjnpZYCepwF https://cassyni.com/events/QYkfoeKbH1XEjnpZYCepwF/abstract https://cassyni-user-files-prod.s3.amazonaws.com/J2MrPPWoFPWupJtRFvMNTQ https://cassyni.com/events/QYkfoeKbH1XEjnpZYCepwF?videoPreview=1 Thieme Cheminar: Modern Strategies in Organofluorine Chemistrynohttps://cassyni.com/events/QYkfoeKbH1XEjnpZYCepwF?videoPreview=12025-09-29T12:00:00+00:004502.6Thieme GroupOrganofluorine compounds play a vital role across diverse sectors—from medicine and agriculture to materials science and imaging technologies. Their widespread use is made possible by continuous advances in synthetic methods, enabling access to both established and emerging fluorinated motifs; recent developments are covered in the Science of Synthesis volumes on Modern Strategies in Organofluorine Chemistry, edited by Jean-François Paquin. In this webinar, Tatiana Besset and Kevin Lam will share perspectives on recent developments in the field, highlighting evolving strategies and challenges in the synthesis of fluorinated molecules. The session will offer a broad overview of current trends and future directions in organofluorine chemistry.https://cassyni-user-files-prod.s3.amazonaws.com/J2MrPPWoFPWupJtRFvMNTQ https://cassyni.com/events/M5rLzg6Py7c4TkXBJntzry/abstract https://cassyni-user-files-prod.s3.amazonaws.com/VSUHTxqsUHzABwnivVZHWn