https://cassyni.com/slides/outline/AUUJnZzLazEA2QzqUGSeX7 https://cassyni.com/events/AUUJnZzLazEA2QzqUGSeX7/abstract https://cassyni-user-files-prod.s3.amazonaws.com/SasEPj5NqNwJkWvpFPzs6n https://cassyni.com/events/AUUJnZzLazEA2QzqUGSeX7?videoPreview=1 AI for Computational Physics: Toward real-time high-fidelity simulationnohttps://cassyni.com/events/AUUJnZzLazEA2QzqUGSeX7?videoPreview=12021-04-09T14:00:00+00:004208.52AI Institute in Dynamic SystemsThe explosion of artificial intelligence—especially techniques arising from deep neural networks—has yielded exciting advances in fields such as computer vision, natural language processing, and reinforcement learning. However, the application of these methods to problems in engineering and science remains limited. In this talk, we describe how two particular recent advances in deep learning, namely convolutional autoencoders and long-short-term-memory (LSTM) recurrent neural networks (RNNs) can be employed to overcome two longstanding challenges in nonlinear model reduction: the Kolmogorov limitation of linear subspaces, and accurate error quantification.https://cassyni-user-files-prod.s3.amazonaws.com/SasEPj5NqNwJkWvpFPzs6n https://cassyni.com/events/NKR7P8BSG38tMNrUjVHPwj/seminar/qa https://cassyni.com/slides/outline/NKR7P8BSG38tMNrUjVHPwj https://cassyni.com/events/NKR7P8BSG38tMNrUjVHPwj/abstract https://cassyni-user-files-prod.s3.amazonaws.com/9Nk8kprEytBsoUTs6EYu18 https://cassyni.com/events/NKR7P8BSG38tMNrUjVHPwj?videoPreview=1 TChem: A Performance Portable Parallel Software Toolkit for Complex Kinetic Mechanismsnohttps://cassyni.com/events/NKR7P8BSG38tMNrUjVHPwj?videoPreview=12023-08-22T15:00:00+00:003551.72Computer Physics CommunicationsWe present TChem, a performance portable software toolkit to enable the analysis of complex kinetic mechanisms. The software provides tools for gas-phase and surface chemistry, thermodynamic properties, and implements formulations for several canonical reactor models. Analytical derivatives necessary to construct Jacobian matrices corresponding to all implemented functionalities are available through automatic differentiation. TChem uses the Kokkos framework to achieve portability across multiple heterogeneous computing platforms with a single version of the code. We implement a hierarchical parallelism framework to enable efficient chemical source term and thermodynamic property evaluations over the number of samples assigned to the local computing device. We analyze parallel efficiency results extracted from test cases for thermodynamic properties, source terms, and Jacobians evaluations on Intel Xeon CPUs and NVIDIA Volta GPUs. https://cassyni-user-files-prod.s3.amazonaws.com/9Nk8kprEytBsoUTs6EYu18 https://cassyni.com/slides/outline/HNw4vHiBsTbrxH98j1aQDb https://cassyni.com/events/HNw4vHiBsTbrxH98j1aQDb/abstract https://cassyni-user-files-prod.s3.amazonaws.com/R5UaC3tGr4kkLLmgqViWMU https://cassyni.com/events/HNw4vHiBsTbrxH98j1aQDb?videoPreview=1 Discrepancy Modeling with Physics Informed Machine Learningnohttps://cassyni.com/events/HNw4vHiBsTbrxH98j1aQDb?videoPreview=12022-08-05T12:00:00+00:001149.88Brunton LabThis video describes how to combine machine learning with classical physics models to correct for discrepancies in the data (e.g., from nonlinear friction, wind resistance, etc.). Several examples are covered, from modern robotics, to classical connections with Galileo v. Aristotle, and Kepler v. Ptolemy. The examples in this video highlight work and discussions with Prof. Nathan Kutz, especially connections to classical scientific discoveries. SLB acknowledges support from the National Science Foundation AI Institute in Dynamic Systems (grant number 2112085).https://cassyni-user-files-prod.s3.amazonaws.com/R5UaC3tGr4kkLLmgqViWMU https://cassyni.com/events/Qnf8cYR4TKuhSrfbgtS8db/seminar/qa https://cassyni.com/slides/outline/Qnf8cYR4TKuhSrfbgtS8db https://cassyni.com/events/Qnf8cYR4TKuhSrfbgtS8db/abstract https://cassyni-user-files-prod.s3.amazonaws.com/RQ5TugN7bisna5F7UDPxFg https://cassyni.com/events/Qnf8cYR4TKuhSrfbgtS8db?videoPreview=1 Hydrogen-Powered Aircraft: Concepts, Technologies, and Environmental Impactnohttps://cassyni.com/events/Qnf8cYR4TKuhSrfbgtS8db?videoPreview=12023-03-07T15:00:00+00:003563.88Brahmal Vasudevan Institute for Sustainable AviationCivil aviation has an outsized social and economic influence and is indispensable in the global economy. However, aircraft have a negative impact on the environment. Society needs revolutionary aircraft technology to meet environmental goals and sustain the civil aviation industry. Hydrogen aircraft have the potential to fly existing routes with no carbon emissions and reduce or eliminate other emissions. In the long term, hydrogen aircraft appear to be the most compelling alternative to today's kerosene-powered aircraft. Using hydrogen also enables novel technologies, such as fuel cells and superconducting electronics, which could lead to aircraft concepts that are not feasible with kerosene. Hydrogen aircraft introduce technical challenges. While they appear technically feasible, they require further development of hydrogen storage tanks, fuel systems, and propulsion technologies.https://cassyni-user-files-prod.s3.amazonaws.com/RQ5TugN7bisna5F7UDPxFg https://cassyni.com/events/TFu9qxegecgBoo9AEaLmMX/abstract https://cassyni-user-files-prod.s3.amazonaws.com/XBPGL6WDo1hWdXuKU14Lcn https://cassyni.com/events/2ZUwXnJShizEeLrRiMkffs/abstract https://cassyni-user-files-prod.s3.amazonaws.com/K5kZj1nqfYUHaYuYuGJ5US https://cassyni.com/events/623nyCM1BHneVjccZgxo7b/seminar/qa https://cassyni.com/slides/outline/623nyCM1BHneVjccZgxo7b https://cassyni.com/events/623nyCM1BHneVjccZgxo7b/abstract https://cassyni-user-files-prod.s3.amazonaws.com/93JHoRvEN1xVrw87wgs51G https://cassyni.com/events/623nyCM1BHneVjccZgxo7b?videoPreview=1 Hydrodynamic stabilitynohttps://cassyni.com/events/623nyCM1BHneVjccZgxo7b?videoPreview=12023-06-13T14:30:00+00:003956.64NEKTAR++Continuation methods are often used when tracking interesting states of a dynamical system, such as unstable saddle points that are important for the organization of system’s dynamics. In turbulent flows and turbulent transition process itself such states play an organizing role and act by attracting the flow solution along their stable manifold only to eject it along respective unstable trajectories and resulting in complex evolution patterns. This fact alone makes such states an interesting research topic. With the use of continuation techniques one is able to determine conditions when such states are created as well as navigate respective branches of those solutions. One of the problems, though is the ability of standard tools to navigate and converge close to the bifurcation points, where systems often become singular. In this work we will present our approach and discuss the Nektar++ implementation of the methods used for the continuation and turning around bifurcations. In this study, our objective is to mitigate the buoyant instability inherent in mixed baroclinic convection within a cavity by employing an advanced optimisation technique. We consider a nearly semi-cylindrical cavity featuring an upper free surface through which fluid can enter, and porous lower boundaries through which fluid can exit. The cavity consists of a semicircular lower boundary, two adiabatic sidewalls, and extends infinitely in the third direction. This specific configuration is pertinent to situations involving molten solid materials, such as in metallurgical casting processes. Our previous stability analysis of this problem revealed the presence of three-dimensional unstable modes [1]. Additionally, the receptivity analysis indicated that the through-flow at the centre of the inlet exhibits the highest receptivity. Given the inlet’s receptiveness, our focus is on identifying the optimal perturbation in the inflow profile capable of suppressing this instability. To accomplish this, we implemented an optimisation solver within the Nektar++ framework [2] to search for the optimal inflow perturbation with a prescribed time-dependence [3]. Preliminary results demonstrate that the optimised inflow profile effectively dampens the linear growth of the unstable mode for a specific duration. Improving mixing efficiency is a way to improve performance of numerous flow-based devices and a common approach is flow turbulisation, but however effective, this approach is not always desirable or realizable. Processing of highly viscous fluids, microfluidic applications or biological flows containing sheer-sensitive molecules calls for laminar mixing to be applied. Mixing in the laminar regime is particularly difficult since flows remain dominated by viscous effects and lacks strong advection and stirring. It is known that channel corrugation might result in the onset of hydrodynamic instabilities, leading to complex flow patterns and consequently improved mixing via principles of chaotic advection. In this work we perform Direct Numerical Simulation (DNS) of low Reynolds number, pressure driven flow in a doubly-periodic, corrugated channel (both symmetrically, and asymmetrically, with one wall corrugated and one flat) to analyse mixing inspired by hydrodynamic instabilities. Flows of varying Reynolds and Schmidt numbers are simulated to analyse mixing in different advective and diffusive conditions. We compare obtained asymmetric channel results with results in symmetry preserving corrugated channel using the rate of exponential decay of variance and negative index Sobolev mix-norm – norm similar to variance (and L2 norms in general), but overcoming its main flaw, which is performance in limit cases of low diffusivity. As the variance time derivative explicitly depends on diffusivity only, it can fail to properly measure mixing in cases where the advective stirring highly exceed the diffusion impact on mixing, while the mix-norm includes “smoothing” operator, overcoming this problem. Sobolev mix-norms, as well as the flow itself, were calculated with the Nektar++ tools. We also utilize and visualise the strange-eigenmodes – structures persistent in time in cases with laminar mixing induced by the chaotic advection and corresponding to eigen functions of the advection diffusion operator. https://cassyni-user-files-prod.s3.amazonaws.com/93JHoRvEN1xVrw87wgs51G https://cassyni.com/slides/outline/CST2TTEwUt4ZVrrTDvX2oo https://cassyni.com/events/CST2TTEwUt4ZVrrTDvX2oo/abstract https://cassyni-user-files-prod.s3.amazonaws.com/YXKTtyXmeNnTfMtGTpjFMY https://cassyni.com/events/CST2TTEwUt4ZVrrTDvX2oo?videoPreview=1 2D axisymmetric and 3D CFD simulations of flow over the benchmark DARPA SUBOFF submarine modelnohttps://cassyni.com/events/CST2TTEwUt4ZVrrTDvX2oo?videoPreview=12023-05-31T10:00:00+00:003226.2Cassyni Seminars### What is it about? *Turbulent flow is fundamentally three-dimensional (3D), but two-dimensional (2D) axisymmetric computational fluid dynamics (CFD) models of axial viscous flow over streamlined axisymmetric bodies yield quick results that are approximate but very useful for preliminary studies. This is shown by comparing the results of 2D axisymmetric and 3D CFD (STAR-CCM+) models of axial flow over the Defense Advanced Research Project Agency submarine model known as the DARPA SUBOFF*. ### Why is it important? *The CFD community is always in search of methods to reduce the overall computational time – preferably by large factors. The detailed illustration using the much-studied DARPA SUBOFF shows that this 2D axisymmetric model, in addition to being fast by a factor of more than 300, yields results for the total drag, the wall shear stress and wall pressure coefficients, and the velocity profile within the boundary layer at various locations on the body that are very nearly the same as those obtained using 3D simulations. The difference between the 2D CFD drag at a Reynolds number of 35.35 million and experimental results is only +2.05%. Thus, the method is ideally suited for preliminary optimization studies*. ### Perspectives of Authors *The model chosen for use in any application depends on the outputs of interest. The simplest and fastest model that yields results with sufficiently low errors is the most desirable one. The model should also be robust and work well for new applications. In the preliminary design stage, a large number of options should be tried and ranked. Sub-optimal designs are often used because of the lack of time to investigate more options. A large database allows the chief designer to choose an appropriate option after considering various trade-offs. It is shown that the 2D axisymmetric model is well suited for preliminary design and the ranking of options. The error in the total drag is low and the flow in the nose and tail regions is shown to be computed with low errors. High accuracy is obtained by stating and using a few guidelines for meshing. The level of rigor in the verification and validation of the results is high and is rarely seen in recent literature. This should inspire confidence among the CFD community to use this method to study flows over streamlined axisymmetric bodies and new applications.* This work is a joint collaboration with Dr. Manoj T. Issac and Dr. D. D. Ebenezer. https://cassyni-user-files-prod.s3.amazonaws.com/YXKTtyXmeNnTfMtGTpjFMY https://cassyni.com/slides/outline/KrCiGLThU7J88v5KUNKCrR https://cassyni.com/events/KrCiGLThU7J88v5KUNKCrR/abstract https://cassyni-user-files-prod.s3.amazonaws.com/R7bQCipu4WUwuKhMuf7cuU https://cassyni.com/events/KrCiGLThU7J88v5KUNKCrR?videoPreview=1 Inertial Particle Focusing in Curved Ducts: Bifurcation and Dynamicsnohttps://cassyni.com/events/KrCiGLThU7J88v5KUNKCrR?videoPreview=12023-07-05T10:00:00+00:002370.48Cassyni SeminarsParticles suspended in fluid flow through a curved duct can focus to stable equilibrium positions in the duct cross-section due to the balance of two dominant forces - inertial lift force from axial flow and secondary drag force from cross-sectional vortices. Such particle focusing is exploited in various medical and industrial technologies aimed at separating particles by size. In this talk, we will present results of our numerical investigation of the dynamics of neutrally buoyant particles in fluid flow through curved ducts. We will show that rich bifurcations take place in the particle equilibria as a function of system parameters. We will offer insights on how these bifurcations in combination with particle dynamics can be exploited to separate particles of different sizes in circular and spiral ducts.https://cassyni-user-files-prod.s3.amazonaws.com/R7bQCipu4WUwuKhMuf7cuU https://cassyni.com/events/WiU1HNhF8BUbfBuM5uYtoF/seminar/qa https://cassyni.com/slides/outline/WiU1HNhF8BUbfBuM5uYtoF https://cassyni.com/events/WiU1HNhF8BUbfBuM5uYtoF/abstract https://cassyni-user-files-prod.s3.amazonaws.com/T89wdxkPvtgXanGQbXJyy8 https://cassyni.com/events/WiU1HNhF8BUbfBuM5uYtoF?videoPreview=1 Composite Design for Novel Energy Harvesting and Sensing Structuresnohttps://cassyni.com/events/WiU1HNhF8BUbfBuM5uYtoF?videoPreview=12023-05-26T13:00:00+00:002894.0Department of AeronauticsThe presentation will overview ferroelectric materials for sensing and harvesting via piezoelectric and pyroelectric effects. The role of forming porous and composite architectures will be examined to improve their interaction with mechanical and thermal loads for improved sensors and low power harvesting. Examples will include the harvesting of mechanical energy, thermal energy, and chemical energy using ferroelectric materials. The motivation of this work is the continuing need for reduced power requirements for small electronic components, such as wireless sensor networks. It will overview of piezoelectric harvesting system along with the closely related sub- classes of pyroelectrics and ferroelectrics. These properties are, in many cases, present in the same material, providing the intriguing prospect of a material that can harvest energy from multiple sources including vibration and thermal fluctuations. Examples of modelling and manufacture of porous materials and pyroelectric harvesting are discussed and the potential of novel sandwich structures and porous materials are also described. Water-splitting using pyroelectric materials are examined analytically and experimentally.https://cassyni-user-files-prod.s3.amazonaws.com/T89wdxkPvtgXanGQbXJyy8 https://cassyni.com/slides/outline/RHLMmraUJ9PXGKf7UzZ6oo https://cassyni.com/events/RHLMmraUJ9PXGKf7UzZ6oo/abstract https://cassyni-user-files-prod.s3.amazonaws.com/NjEW5YuQRJsespm7Hg6AjY https://cassyni.com/events/RHLMmraUJ9PXGKf7UzZ6oo?videoPreview=1 Crystallisation and characterisation of muscle proteins: a mini-reviewnohttps://cassyni.com/events/RHLMmraUJ9PXGKf7UzZ6oo?videoPreview=12023-06-30T13:00:00+00:001061.8Imperial College London Early Career Researcher InstituteThe techniques of X-ray protein crystallography, NMR and high-resolution cryo-electron microscopy have all been used to determine the high-resolution structure of proteins. The most-commonly used method, however, remains X-ray diffraction but it does rely heavily on the production of suitable crystals. Indeed, the production of diffraction quality crystals remains the rate-limiting step for most protein systems. Crystallisation trials, initiated by John Squire with the assistance of the authors, used existing and newly developed crystallisation methods for two different muscle proteins - the actin binding domain (ABD) of α-actinin and the C0-C1 domain of human cardiac myosin binding protein C (cMyBP-C). Diffracting crystals of α-actinin ABD, with a resolution of 1.9Å, however, did not prove to be in a form suitable for diffraction methods. In contrast, when the C0-C1 domain of cMyBP-C underwent proteolysis during crystallogenesis very satisfactory crystals of the C1 domain were obtained. These employed a modified hanging drop vapour diffusion method and diffracted to high resolution (1.5Å). This has led to the determination of the structure of the C1 domain of cMyBP-C at atomic resolution and has thereby provided new insights into its function. https://cassyni-user-files-prod.s3.amazonaws.com/NjEW5YuQRJsespm7Hg6AjY https://cassyni.com/slides/outline/8VHpCcadNaZ8rg6B7NsRqX https://cassyni.com/events/8VHpCcadNaZ8rg6B7NsRqX/abstract https://cassyni-user-files-prod.s3.amazonaws.com/GD36kmddKB3mCxuNG9DFtS https://cassyni.com/events/8VHpCcadNaZ8rg6B7NsRqX?videoPreview=1 The Rashomon Effect in Financial Reporting: Exploring Multi-Interpretation Phenomenon in the Case of Garuda Indonesia's Annual Financial Statementsnohttps://cassyni.com/events/8VHpCcadNaZ8rg6B7NsRqX?videoPreview=12023-08-17T23:00:00+00:004343.16SACLThis study examines the phenomenon of multi-interpretation in financial reporting through the lens of the Rashomon effect, using the case of Garuda Indonesia's annual financial statements. Drawing inspiration from Akira Kurosawa's film, Rashomon, which portrays a single event from different characters’ perspectives, this research interviews four key stakeholders: auditors, academicians, regulators, and users. The findings reveal that, similar to the film, each stakeholder offers a distinct interpretation of the financial transactions between Garuda Indonesia and Mahata Aero Teknologi. The root cause of the issue lies in adopting principle-based accounting standards, which leads to differing interpretations and perceptions. The implications of this study highlight the need for continuous collaboration and coordination among regulators, auditors, academicians, and users to enhance accounting literacy and foster a deeper understanding of accounting principles. It is crucial to address the limitations posed by principle-based standards and explore the potential transition to rule-based standards to minimize the occurrence of multi-interpretation cases in financial reporting. This research provides valuable insights for stakeholders involved in financial reporting, aiding in identifying challenges and formulating effective strategies to promote transparency and accuracy in financial statements. Financial statements provide essential information about a company's financial performance and position. They are intended to assist many users in making informed economic decisions. However, a significant challenge arises when interpreting financial statements accurately and consistently. The interpretation of financial statements is prone to multiple perspectives, leading to diverse and sometimes contradictory understandings of the same information.https://cassyni-user-files-prod.s3.amazonaws.com/GD36kmddKB3mCxuNG9DFtS https://cassyni.com/events/15ZkWMskniFd6duGZDFoPT/seminar/qa https://cassyni.com/slides/outline/15ZkWMskniFd6duGZDFoPT https://cassyni.com/events/15ZkWMskniFd6duGZDFoPT/abstract https://cassyni-user-files-prod.s3.amazonaws.com/S2HaF36zCWnHiuC5dWK8mC https://cassyni.com/events/15ZkWMskniFd6duGZDFoPT?videoPreview=1 Numerical simulations of aerofoil tonal noise reduction by roughness elementsnohttps://cassyni.com/events/15ZkWMskniFd6duGZDFoPT?videoPreview=12023-09-21T14:00:00+00:002383.4PyFRIn a combined experimental and numerical effort we investigate aerofoil tonal noise generation and reduction. The means of noise control are streak generators in form of cylindrical roughness elements. These elements are placed periodically along the span of aerofoil at the mid chord streamwise position. Experiments are performed for a wide range of Reynolds number and angle of attack. In the present work we concentrate on our numerical investigations. We have performed wall-resolved LES for a given angle of attack of 0 degree and Mach 0.3. Two Reynolds numbers 0.8 × 105 and 1.0 × 105 have been investigated. Through Fourier decomposition and POD analysis of streamwise stations velocity data, dominating structures have been identified. Further, the coupling between structures generated by surface roughness and instability modes (Kelvin-Helmholtz) of shear layer has been identified. https://cassyni-user-files-prod.s3.amazonaws.com/S2HaF36zCWnHiuC5dWK8mC https://cassyni.com/events/Fu1stsHVxSryMFce5FjAFX/seminar/qa https://cassyni.com/slides/outline/Fu1stsHVxSryMFce5FjAFX https://cassyni.com/events/Fu1stsHVxSryMFce5FjAFX/abstract https://cassyni-user-files-prod.s3.amazonaws.com/DPNqjFqe7Fs6FmZH2wyDYi https://cassyni.com/events/Fu1stsHVxSryMFce5FjAFX?videoPreview=1 Session 8 - Deciphering the SUMO code for adaptive responses in plantsnohttps://cassyni.com/events/Fu1stsHVxSryMFce5FjAFX?videoPreview=12023-07-04T06:00:00+00:002073.48New Phytologist Foundation Post-translational modification (PTM) events generate proteoforms that orchestrate cell signalling in almost every biological process. The SUMOcode project aims to understand a critically important but understudied PTM in plants, SUMO (Small Ubiquitin-like Modifier). The rules governing specificity and function remain rudimentary for most PTMs, but the plant SUMO system provides a unique possibility to unravel the rules governing SUMOylation, as its core machinery comprises only 33 genes in Arabidopsis, compared with many hundreds for other PTMs. Our central hypothesis is that SUMO specificity is conferred through how cells are primed to respond to different stress signals, the tissue and cellular spatial distribution of SUMO machinery and substrates and control of SUMOylation modification via activation, repression and competition for PTM sites. We have developed a SUMO system cell atlas (a resource that will characterize each part of the machinery), how and in which cells and when it works, so that a map of the key events that trigger a SUMOylation response to environmental cues can be revealed. https://cassyni-user-files-prod.s3.amazonaws.com/DPNqjFqe7Fs6FmZH2wyDYi https://cassyni.com/events/ATtEPMAj8QmtxPNQULjNG5/seminar/qa https://cassyni.com/slides/outline/ATtEPMAj8QmtxPNQULjNG5 https://cassyni.com/events/ATtEPMAj8QmtxPNQULjNG5/abstract https://cassyni-user-files-prod.s3.amazonaws.com/RQb2Z6172mKF6DJHTgzQZC https://cassyni.com/events/ATtEPMAj8QmtxPNQULjNG5?videoPreview=1 Rooted Hypersequent Calculus for Modal Logic S5nohttps://cassyni.com/events/ATtEPMAj8QmtxPNQULjNG5?videoPreview=12023-07-12T14:00:00+00:003622.68Logica UniversalisWe present a rooted hypersequent calculus for modal propositional logic S5. We show that all rules of this calculus are invertible and that the rules of weakening, contraction, and cut are admissible. Soundness and completeness are established as well.https://cassyni-user-files-prod.s3.amazonaws.com/RQb2Z6172mKF6DJHTgzQZC https://cassyni.com/slides/outline/AxXqS2pFZsKwx9uJ4n2AXP https://cassyni.com/events/AxXqS2pFZsKwx9uJ4n2AXP/abstract https://cassyni-user-files-prod.s3.amazonaws.com/8gqazmz21yffY5P9GpVhQS https://cassyni.com/events/AxXqS2pFZsKwx9uJ4n2AXP?videoPreview=1 Manifolds in the Solar System and application to L4-L5 asymmetry of Trojan asteroidsnohttps://cassyni.com/events/AxXqS2pFZsKwx9uJ4n2AXP?videoPreview=12022-09-08T16:45:00+00:00900.04Celestial Mechanics and Dynamical AstronomyThe arches of chaos (Todorović et al. 2020) consist in an ornamental structure of manifolds generated by all planets connected in a series of arches that spread throughout the whole Solar System. In this work we propose to investigate the nature of the strongest ones, stemming from Jupiter, and their implications for small body dynamics in the various regions of the phase-space. As a pivotal case, we consider the well-known open problem in our solar system concerning the observed asymmetry in the number and phase-space distribution of Trojan asteroids around Jupiter's equilateral equilibrium points L4 and L5. We discuss possible links of this problem to an observed dynamical asymmetry affecting the heteroclinic intersections (with various other periodic orbits) of the two opposite branches of the stable and unstable manifolds of the short-period family of unstable periodic orbits emanating from the Lagrangian point L3 for different energy and inclination regimeshttps://cassyni-user-files-prod.s3.amazonaws.com/8gqazmz21yffY5P9GpVhQS https://cassyni.com/slides/outline/MLB9X1vABqt6dSUgLHWq4h https://cassyni.com/events/MLB9X1vABqt6dSUgLHWq4h/abstract https://cassyni-user-files-prod.s3.amazonaws.com/mm8MCvfsZvFT2VMEC4bVx https://cassyni.com/events/MLB9X1vABqt6dSUgLHWq4h?videoPreview=1 Computation and study of periodic orbits in the case of the Laplace resonancenohttps://cassyni.com/events/MLB9X1vABqt6dSUgLHWq4h?videoPreview=12022-09-08T14:45:00+00:00487.48Celestial Mechanics and Dynamical AstronomyThe Laplace resonance is a major case of three-body resonances. A well-known example in our Solar system is observed in the case of the three inner Galilean satellites, Io, Europa and Ganymede and involves commensurability among the mean motions of the satellites. The aim of this work is to study the structure of the periodic orbits which is approached by implementing a model that includes the gravitational interaction with Jupiter, the mutual gravitational interactions of the satellites and the effects due to the oblateness of Jupiter. The families of periodic orbits are computed numerically and the linear stability of the families is studied. This study is crucial in order to understand the dynamical endstates allowed in the framework of the Laplace resonance and compare with the observed values of the Galilean satellites.https://cassyni-user-files-prod.s3.amazonaws.com/mm8MCvfsZvFT2VMEC4bVx https://cassyni.com/slides/outline/LLswRed7JvmwxgegEK3WFo https://cassyni.com/events/LLswRed7JvmwxgegEK3WFo/abstract https://cassyni-user-files-prod.s3.amazonaws.com/E7Fi8pPCDQjg5jSuubUwCr https://cassyni.com/events/LLswRed7JvmwxgegEK3WFo?videoPreview=1 The DeSci Movementnohttps://cassyni.com/events/LLswRed7JvmwxgegEK3WFo?videoPreview=12022-12-19T17:00:00+00:003703.24DeSci FoundationScience is humanity's engine for progress. In his seminar, Juan presents how the DeSci movement might transform science in the next decade. He covers the gap between basic research and technological development - the innovation chasm - as well as new ideas for funding research.https://cassyni-user-files-prod.s3.amazonaws.com/E7Fi8pPCDQjg5jSuubUwCr https://cassyni.com/slides/outline/XD9ESgrexzxRUxUhqrHCCd https://cassyni.com/events/XD9ESgrexzxRUxUhqrHCCd/abstract https://cassyni-user-files-prod.s3.amazonaws.com/J8XTZXWbBDtwJeWy9PWWYW https://cassyni.com/events/XD9ESgrexzxRUxUhqrHCCd?videoPreview=1 First Steps in Verified Placement, Routing and Timingnohttps://cassyni.com/events/XD9ESgrexzxRUxUhqrHCCd?videoPreview=12023-09-12T10:30:00+00:001796.48HiPEDS CentreDoing any formal reasoning below the boolean abstraction of hardware gates is very unusual, mostly because the models of hardware below this abstraction layer are, at least to me, vague and/or complicated. In this talk, I will present a not-so-serious work-in-progress project on formal reasoning below the level of the boolean abstraction of hardware gates. More precisely, I will explain how hardware gates realised in Conway's Game of Life can be verified and how verified circuits consisting of such gates can be developed. This project touches on verification of placement, routing and timing, which are topics I suspect formal verification in interactive theorem provers have not explored before.https://cassyni-user-files-prod.s3.amazonaws.com/J8XTZXWbBDtwJeWy9PWWYW https://cassyni.com/slides/outline/UjuDDGd2miBw8219JANZUh https://cassyni.com/events/UjuDDGd2miBw8219JANZUh/abstract https://cassyni-user-files-prod.s3.amazonaws.com/LQXAUXt8oznYzZrp5PQpQN https://cassyni.com/events/UjuDDGd2miBw8219JANZUh?videoPreview=1 Polydispersity - implications for granular material behaviour and modelling challengesnohttps://cassyni.com/events/UjuDDGd2miBw8219JANZUh?videoPreview=12021-03-11T12:00:00+00:004242.68Granular MatterA lot of studies in granular mechanics have restricted consideration to materials with a relatively narrow range of particle sizes. However engineers have long recognised that the range of sizes in a granular material significantly influences its mechanical behaviour. Quantifying the polydispersity, i.e. determining the particle size distribution, is one of the most basic characterizations we perform on granular materials. However, our understanding of how changes in the particle size distribution influence the mechanical behaviour of granular materials is incomplete. Recently generated DEM data provide a new perspective on how changes in the particle size distribution change the fabric, the distribution of stresses and stress wave propagation in polydisperse granular materials. Gap graded materials (i.e. materials with two distinct size fractions) have attracted a lot of interest in geomechanics over the past decade. Our DEM data indicate that some of the hypotheses that have emerged are not robust; for the concept of a transitional fines content is not supported by our data. Through these studies key challenges associated with using DEM to simulate polydisperse materials have emerged: large numbers of particles must be considered and the accuracy of the coarse grained approach often used in DEM-CFD modelling is compromised.https://cassyni-user-files-prod.s3.amazonaws.com/LQXAUXt8oznYzZrp5PQpQN https://cassyni.com/events/Tkc17uKyto5nTGB9CBuEfo/seminar/qa https://cassyni.com/slides/outline/Tkc17uKyto5nTGB9CBuEfo https://cassyni.com/events/Tkc17uKyto5nTGB9CBuEfo/abstract https://cassyni-user-files-prod.s3.amazonaws.com/H85i3hebVZpPVp7MTkMibQ https://cassyni.com/events/Tkc17uKyto5nTGB9CBuEfo?videoPreview=1 Confidence Distributions for Skew Normal Change Point Model Based on Modified Information Criterionnohttps://cassyni.com/events/Tkc17uKyto5nTGB9CBuEfo?videoPreview=12023-08-24T14:00:00+00:004233.12Journal of Statistical Theory and PracticeIn this paper, we consider a skew normal change-point model. Instead of only providing the point estimate of the change location, we propose an estimating procedure based on the confidence distribution combining with the modified information criterion to construct the confidence set for the change location. The simulations indicate the advantages of the proposed method comparing to the existing method in terms of coverage probabilities and average lengths of the confidence sets, especially when the change occurs at the very beginning or in the very end. The proposed method is applied to two stock market data to illustrate the detection and the estimation procedures.https://cassyni-user-files-prod.s3.amazonaws.com/H85i3hebVZpPVp7MTkMibQ https://cassyni.com/slides/outline/6Wj28WWR27GUKWByKdh6Wy https://cassyni.com/events/6Wj28WWR27GUKWByKdh6Wy/abstract https://cassyni-user-files-prod.s3.amazonaws.com/D8bA53G5m1sgsr6dBnbiTQ https://cassyni.com/events/6Wj28WWR27GUKWByKdh6Wy?videoPreview=1 Generative Volumetric Video for Interactive Virtual Humansnohttps://cassyni.com/events/6Wj28WWR27GUKWByKdh6Wy?videoPreview=12023-01-12T12:30:00+00:002975.0Journal on Image and Video ProcessingPhoto-realistic modelling and rendering of humans is extremely important for virtual reality (VR) environments, as the human body and face are highly complex and exhibit large shape variability but also, especially, as humans are extremely sensitive to looking at humans. Further, in VR environments, interactivity plays an important role. While purely computer graphics modeling can achieve highly realistic human models, achieving real photo-realism with these models is computationally extremely expensive. Hence, more and more hybrid methods have been proposed in recent years. In this talk, the creation of high-quality animatable volumetric video content of human performances is addressed. Recent progress in learning human motion and appearance, neural rendering, and implicit function rendering (e.g. NeRF) enable the creation of realistic representation of virtual humans. We combine these approaches with classical models in order to obtain full control for body and face animation. Different concepts ranging from animatable volumetric video to pure data driven representation will be presented that target the realistic animation of virtual humans for different applications.https://cassyni-user-files-prod.s3.amazonaws.com/D8bA53G5m1sgsr6dBnbiTQ https://cassyni.com/slides/outline/71NdBC9wTZpXKGirv4ytnH https://cassyni.com/events/71NdBC9wTZpXKGirv4ytnH/abstract https://cassyni-user-files-prod.s3.amazonaws.com/5MNtbGpZr49n8Xbpqkrb8i https://cassyni.com/events/71NdBC9wTZpXKGirv4ytnH?videoPreview=1 Towards next generation JPEG standardsnohttps://cassyni.com/events/71NdBC9wTZpXKGirv4ytnH?videoPreview=12021-02-04T12:30:00+00:004064.72Journal on Image and Video ProcessingNo abstracthttps://cassyni-user-files-prod.s3.amazonaws.com/5MNtbGpZr49n8Xbpqkrb8i https://cassyni.com/events/8yy3Mvk3DQ3HQz16H2qqCq/seminar/qa https://cassyni.com/slides/outline/8yy3Mvk3DQ3HQz16H2qqCq https://cassyni.com/events/8yy3Mvk3DQ3HQz16H2qqCq/abstract https://cassyni-user-files-prod.s3.amazonaws.com/7fXJLVUnwbXbDznGHc5Qrz https://cassyni.com/events/8yy3Mvk3DQ3HQz16H2qqCq?videoPreview=1 The stratified inclined duct: what we have learned about stratified turbulence in a maintained shear flownohttps://cassyni.com/events/8yy3Mvk3DQ3HQz16H2qqCq?videoPreview=12023-11-15T16:00:00+00:003200.16Department of AeronauticsThe stratified inclined duct (SID) is a relatively new experimental paradigm that produces a sustained shear flow between two counterflowing layers of fluid supplied by reservoirs at each end of the duct containing fluids of different density. The duct can be tilted at a small angle θ to the horizontal and, for a given fluid, the flow is determined by two nondimensional parameters θ and the Reynolds number. We have observed four different flow regimes in SID: Laminar when the interface between the layers remains undisturbed, Holmboe characterised by sharp cusped waves on the interface, Intermittent when the flow has bursts of turbulence followed by relatively calm periods and Turbulent when the turbulence occurs throughout the duct and is sustained in time. The laminar regime occurs at low Re and θ, and transitions to the other regimes occur successively as Re and θ increase, so SID allows a systematic study of the different regimes. One of the most important questions in stratified turbulence is the efficiency with which the fluid is mixed. When the stratification is stable, with density decreasing with height, work needs to be done against gravity to move light fluid downwards and dense fluid upwards so that irreversible mixing can occur. The ‘tax’ that this irreversible mixing imposes on the kinetic energy of the flow, the so-called ‘mixing efficiency’ is important to parameterise mixing in ocean and climate models. In this talk I will discuss the philosophy behind SID and explain why the experiment is relevant to this issue, particularly in the context of the energetics of the flow. We focus first on the self-organisation properties of the flows, wherein more strongly turbulent flows tend to an asymptotic state characterised by a uniform gradient Richardson number of order 0.1-0.2 across the shear layer. We then summarise our results on turbulent energetics and mixing statistics. We derive the kinetic and scalar energy budgets and explain the specificity and scalings of SID turbulence. We assess the relevance of standard mixing parameterisations models, and we compare representative values with the literature. The dependence of these measures of mixing on controllable flow parameters provides asymptotic estimates that may be extrapolated to more strongly turbulent flows. Complementing the experiments we introduce the first accurate 3D DNS for SID. Implementing a suitable forcing method and boundary conditions allow us to maintain steady exchange flow for an arbitrarily long time at a minimal computational cost. With the newly developed numerical model, we explore the diverse transitions in SID from a numerical perspective. https://cassyni-user-files-prod.s3.amazonaws.com/7fXJLVUnwbXbDznGHc5Qrz https://cassyni.com/events/JNK9MYYtxTVHRDAdUjFqi5/seminar/qa https://cassyni.com/slides/outline/JNK9MYYtxTVHRDAdUjFqi5 https://cassyni.com/events/JNK9MYYtxTVHRDAdUjFqi5/abstract https://cassyni-user-files-prod.s3.amazonaws.com/3uWnJmNCJK8B8WY99EvHWv https://cassyni.com/events/JNK9MYYtxTVHRDAdUjFqi5?videoPreview=1 Intersections and Design with Natural Materialsnohttps://cassyni.com/events/JNK9MYYtxTVHRDAdUjFqi5?videoPreview=12024-01-10T15:00:00+00:004726.12Department of AeronauticsMost natural materials are multifunctional composites with complex hierarchical structures, typically built from simple, yet efficient constituent nanoscale biopolymers and biominerals. While we have used biomaterials like wood, flax and silk for diverse applications since pre-historic times, their potential has not been fully-exploited yet. Natural materials are of increasing interest to today’s material world not only for direct usage (to alleviate some of the environmental issues associated with using man-made materials), but also for bioinspiration (to make novel and more efficient man-made materials). At the Centre for Natural Material Innovation, we try to improve performance and functionality in natural materials, and use design to propose them as sustainable alternatives to conventional anthropogenic materials (mainly concrete, steel and plastics) in structural applications. This talk will showcase some of our across-the-length scales, across-supply-chains, interdisciplinary natural materials and design research. The talk will first explore some of the lessons we have learnt through function-structure-property-processing relations in some of nature's marvellous materials and structures, such as: the non-woven silk cocoons of Bombyx Mori silkworms, the highly-oriented filamentous nanocomposite tubes of the Chaetopterus sp. marine worm, the dentinous ivory of elephants, and the polylaminate structure of bamboo and flax cell walls. The talk will then explore the significant opportunities presented by wood and bamboo, and flax and hemp in a large variety of structural applications, from precision-engineered school buildings as carbon-sinks and hemp-insulated retrofit building strategies, to flax biocomposite flying boats and wind turbine blades and bamboo cricket bats. The role of design and policy in increasing uptake of natural materials will be covered. https://cassyni-user-files-prod.s3.amazonaws.com/3uWnJmNCJK8B8WY99EvHWv https://cassyni.com/slides/outline/JrxkQECRPv3LQyhX5AYdyP https://cassyni.com/events/JrxkQECRPv3LQyhX5AYdyP/abstract https://cassyni-user-files-prod.s3.amazonaws.com/FEtV2SfxQnst6vpCyLMcPg https://cassyni.com/events/JrxkQECRPv3LQyhX5AYdyP?videoPreview=1 Introducing Transformative Plant Biotechnology: Innovations to overcome transformation and gene editing bottlenecksnohttps://cassyni.com/events/JrxkQECRPv3LQyhX5AYdyP?videoPreview=12023-09-21T15:30:00+00:001525.0The New Phytologist FoundationBarriers to transformation continue to hamper application of recombinant DNA-based biotechnologies in most crops, including gene editing. Where fully “clean” gene edits are desired to facilitate regulatory approvals, the challenges are even greater. There has been a great deal of excitement about the use of developmental regulator (“DEV”) genes as parts of transformation systems in recent years, with striking improvements in monocot transformation as a result, though dicot systems have also seen improvements reported. We have been studying the extent to which a variety of DEV genes can aid the regeneration of transgenic tissues from clonally propagated forest trees, with a focus on poplar and eucalypts. Generally, the results have been disappointing; the genes have variously helped or inhibited transformation, and effects vary widely with gene source, expression, and plant genotype. We have obtained better and more genotype-independent results with genes that directly affect hormone biosynthesis, which are derived from Agrobacterium. I will present results from our DEV gene forays, including those from using isolated oncogenes from a little used "shooty" strain first discovered by Lise Jouanin and other researchers at INRA/France in the 1990s. Used in a co-transformation ("altruistic") system, these oncogenes have improved the recovery rate and sped the transformation of poplar. **Co-Authors**: Dr. Greg Goralogia and Cathleen Ma, Oregon State University https://cassyni-user-files-prod.s3.amazonaws.com/FEtV2SfxQnst6vpCyLMcPg https://cassyni.com/slides/outline/UFHEHDVPjcZcGjAezJ2Cr1 https://cassyni.com/events/UFHEHDVPjcZcGjAezJ2Cr1/abstract https://cassyni-user-files-prod.s3.amazonaws.com/HWaLKCewy85Nujh21cG4sQ https://cassyni.com/events/UFHEHDVPjcZcGjAezJ2Cr1?videoPreview=1 Thermal Distribution in Earth's Interiornohttps://cassyni.com/events/UFHEHDVPjcZcGjAezJ2Cr1?videoPreview=12021-07-06T12:00:00+00:004742.64Discover Applied SciencesProf. Ann Mescher discusses Thermal Distribution in Earth's Interior.https://cassyni-user-files-prod.s3.amazonaws.com/HWaLKCewy85Nujh21cG4sQ https://cassyni.com/slides/outline/52oq765j76XrmoEpAVCEEZ https://cassyni.com/events/52oq765j76XrmoEpAVCEEZ/abstract https://cassyni-user-files-prod.s3.amazonaws.com/D5JMYxrkih8A4wJK2YdggW https://cassyni.com/events/52oq765j76XrmoEpAVCEEZ?videoPreview=1 CFD for Personalised vascular interventions – short-term solutions vs long term predictionsnohttps://cassyni.com/events/52oq765j76XrmoEpAVCEEZ?videoPreview=12023-06-16T10:00:00+00:003151.64Leeds Institute for Fluid DynamicsVanessa is interested in patient-specific modelling and the development of multi-scale, multi-physics and biologically-oriented models in the cardiovascular field, in order to understand health and disease for individual patients. Vanessa’s approach uses a combination of ICT tools, systems biology approaches and biomechanics (CFD, structural mechanics & FSI). She is interested in inflammation and chronic conditions (atherosclerosis, neo-intimal hyperplasia, in-stent restenosis, etc.) but also, in the utilisation of computational tools for the design and optimisation of cardiovascular devices (mechanical heart valves, stents, LVADs). Vanessa is also interested in exploring the use of sensitivity, robustness, uncertainty and optimisation techniques/tools applied to the modelling and simulation of the cardiovascular system in order to better understand how to translate computational models into the clinic and to produce solid and valid models, to test biological hypotheses. Vanessa leads the group ”MUSE” (Multiscale Cardiovascular Engineering), the only group in UCL devoted to tackle the integration of data and information through models, at multiple length and time scales.https://cassyni-user-files-prod.s3.amazonaws.com/D5JMYxrkih8A4wJK2YdggW https://cassyni.com/events/7W3rLWKMJPJM8jiNiB6rxV/seminar/qa https://cassyni.com/slides/outline/7W3rLWKMJPJM8jiNiB6rxV https://cassyni.com/events/7W3rLWKMJPJM8jiNiB6rxV/abstract https://cassyni-user-files-prod.s3.amazonaws.com/9d4wHAg1CcTvdy7RM19AGv https://cassyni.com/events/7W3rLWKMJPJM8jiNiB6rxV?videoPreview=1 On development of Fluid-Structure Interaction Computational Methods in the context of SPHnohttps://cassyni.com/events/7W3rLWKMJPJM8jiNiB6rxV?videoPreview=12024-01-15T14:00:00+00:003639.28Computer Physics CommunicationsThis talk presents a concise review on the state-of-the-art of developments and future perspectives corresponding to FSI solvers developed within the SPH context. The talk reviews and highlights the potential robustness of entirely Lagrangian meshfree FSI solvers, as new generation computational methods, in reproducing FSI corresponding to extreme events and portrays the future perspectives for systematic developments towards reliable engineering applications with respect to rapid advances in technology and emergence of so-called advanced materials that can result in complex and highly non-linear structural responses. Accordingly, the necessity for reproduction of comprehensive structural responses, including viscoelastic, elastoplastic and progressive damages/failures, by the advanced FSI solvers developed within the SPH context will be highlighted. In this regard, extensions of the structure model are suggested to be conducted in a variationally consistent framework to ensure stability, accuracy and physical reliability including thermodynamic consistency. As an important step for coherent extension of SPH-based structure models towards reproducing viscoelastic structural responses, a brief background of corresponding mathematical & numerical modelling is presented along with some numerical results achieved by an extended Hamiltonian and thus variationally consistent SPH model. Another important, yet commonly overlooked aspect that will be highlighted corresponds to the numerical resolution of the continuity equation in the context of SPH for fluids, i.e., achieving physically consistent density and velocity-divergence fields.https://cassyni-user-files-prod.s3.amazonaws.com/9d4wHAg1CcTvdy7RM19AGv https://cassyni.com/slides/outline/43Wd1ingEBRi73Qp4WiuRf https://cassyni.com/events/43Wd1ingEBRi73Qp4WiuRf/abstract https://cassyni-user-files-prod.s3.amazonaws.com/EL4trV6uL8VEvtRRbQqLyL https://cassyni.com/events/43Wd1ingEBRi73Qp4WiuRf?videoPreview=1 Graded arrays for spatial frequency separation and amplification of water wavesnohttps://cassyni.com/events/43Wd1ingEBRi73Qp4WiuRf?videoPreview=12023-11-28T14:00:00+00:003421.04MetaMATWave-energy converters extracting energy from ocean waves are known to suffer from poor efficiency. We propose structures capable of substantially amplifying water waves over a broad range of frequencies at selected locations, with the idea of enhanced energy extraction. The structures consist of full or C-shaped bottom-mounted cylinders arranged in one-dimensional or two-dimensional arrays, with the cylinder properties or the array spacing graded along the array. Using linear potential-flow theory, it is shown that the energy carried by a plane incident wave is amplified within specified locations, for wavelengths comparable to the array length, and for a range of incident directions. Transfer-matrix analysis is used to analyse the large amplifications and we also show results from recent wave-flume experiments confirming the amplification phenomenon in practice.https://cassyni-user-files-prod.s3.amazonaws.com/EL4trV6uL8VEvtRRbQqLyL https://cassyni.com/events/9UeGXEuT4DX7ESzc58xoP3/seminar/qa https://cassyni.com/slides/outline/9UeGXEuT4DX7ESzc58xoP3 https://cassyni.com/events/9UeGXEuT4DX7ESzc58xoP3/abstract https://cassyni-user-files-prod.s3.amazonaws.com/3AYNjjtue8J2d2bUNw9VhY https://cassyni.com/events/9UeGXEuT4DX7ESzc58xoP3?videoPreview=1 Twinning cavities - Making a garage sound identical to a cathedralnohttps://cassyni.com/events/9UeGXEuT4DX7ESzc58xoP3?videoPreview=12024-01-09T14:00:00+00:003276.08MetaMATBounded domains have discrete eigenfrequencies/spectra, and cavities with different boundaries and areas have different spectra. A general methodology for isospectral twinning, whereby the spectra of different cavities are made to coincide, is created by combining ideas from across physics including transformation optics, inverse problems and metamaterial cloaking. We extend this to open cavities where the spectrum is no longer purely discrete and real, and we pay special attention to twinning of leaky modes in 2D open cavities associated with complex valued eigenfrequencies with an imaginary part orders of magnitude lower than the real part. Open cavities are often an essential component in the design of ultra-thin subwavelength metasurfaces and a typical requirement is that cavities have precise, often low frequency, resonances whilst simultaneously being physically compact. To aid this design challenge we develop a methodology to allow isospectral twinning of reference cavities with either smaller or larger ones, enforcing their spectra to coincide so that open resonators are identical in terms of their complex eigenfrequencies. https://cassyni-user-files-prod.s3.amazonaws.com/3AYNjjtue8J2d2bUNw9VhY https://cassyni.com/slides/outline/MpsznxbTS2HhGbvpL4Ty9o https://cassyni.com/events/MpsznxbTS2HhGbvpL4Ty9o/abstract https://cassyni-user-files-prod.s3.amazonaws.com/HPwmbKFiA62v9GSQ8fFBmG https://cassyni.com/events/MpsznxbTS2HhGbvpL4Ty9o?videoPreview=1 Abrupt transitions for turbulent atmosphere and climate dynamicsnohttps://cassyni.com/events/MpsznxbTS2HhGbvpL4Ty9o?videoPreview=12020-11-12T15:00:00+00:003992.92Leeds Institute for Fluid DynamicsIn the past, the Earth and Jupiter atmospheres have experienced fast and drastic transitions, sometimes associated with abrupt climate changes. Some of these changes of turbulent attractors where not caused by external perturbations, but the result of internal variability. Studying such abrupt transitions, for fully turbulent atmosphere dynamics, requires new numerical and theoretical tools. I will present two examples of recent works and new approaches developed in order to study abrupt transitions. First, for Earth like atmospheres, I will discuss the conditions for abrupt transitions to climates with superrotating equatorial jets. I will explain the fluid mechanics mechanisms and parameters that determine whether such transitions are discontinuous or continuous. And second, I will explain the use of rare event algorithms and large deviation theory to study abrupt changes in Jupiter atmosphere, in the turbulent dynamics of either barotropic or two-layer models.https://cassyni-user-files-prod.s3.amazonaws.com/HPwmbKFiA62v9GSQ8fFBmG https://cassyni.com/slides/outline/QJ822Nq5dK4BdYQNskNbsj https://cassyni.com/events/QJ822Nq5dK4BdYQNskNbsj/abstract https://cassyni-user-files-prod.s3.amazonaws.com/LcACPkxd1ZdbgucrMkpLar https://cassyni.com/events/QJ822Nq5dK4BdYQNskNbsj?videoPreview=1 Catastrophically Evaporating Planetsnohttps://cassyni.com/events/QJ822Nq5dK4BdYQNskNbsj?videoPreview=12023-03-02T12:00:00+00:002662.48Leeds Institute for Fluid DynamicsNo abstracthttps://cassyni-user-files-prod.s3.amazonaws.com/LcACPkxd1ZdbgucrMkpLar https://cassyni.com/slides/outline/5XV4GQF8wv1gbGEKxbKCQm https://cassyni.com/events/5XV4GQF8wv1gbGEKxbKCQm/abstract https://cassyni-user-files-prod.s3.amazonaws.com/21G6Lb9owXMC4sL15TufGa https://cassyni.com/events/5XV4GQF8wv1gbGEKxbKCQm?videoPreview=1 The Impact of the Changing Research Landscape on Our Journalsnohttps://cassyni.com/events/5XV4GQF8wv1gbGEKxbKCQm?videoPreview=12024-02-29T09:00:00+00:003574.32Topics at the heart of our communityIn an evermore-crowded journals landscape - which has nearly doubled in size since 2000 - gaining recognition continues to be a challenge for all our editors in attracting high-quality submissions from potential authors. Traditional mechanisms for prospective authors submitting their papers are less successful thanks to a change in researcher behaviour. Join Ritu Dhand, Springer Nature’s Chief Scientific Officer, as she explores key changes in the research publishing landscape over the last decade, and new editorial strategies for how journals can successfully compete to attract high-quality research papers.https://cassyni-user-files-prod.s3.amazonaws.com/21G6Lb9owXMC4sL15TufGa https://cassyni.com/events/4YBrB2x64zuXvWQKrcqsbs/seminar/qa https://cassyni.com/slides/outline/4YBrB2x64zuXvWQKrcqsbs https://cassyni.com/events/4YBrB2x64zuXvWQKrcqsbs/abstract https://cassyni-user-files-prod.s3.amazonaws.com/4gqE37r9etwdBttoexFUYE https://cassyni.com/events/4YBrB2x64zuXvWQKrcqsbs?videoPreview=1 Extinctions along the last legs of the first human migrations to Australianohttps://cassyni.com/events/4YBrB2x64zuXvWQKrcqsbs?videoPreview=12024-07-11T11:00:00+00:002223.04Cambridge PrismsThis presentation will explore the Pleistocene and Holocene extinction records along the routes of ancient and modern human migrations to Australia. Beginning with *Homo erectus* and their arrival in Southeast Asia, I will describe efforts to model their movements through the region and the impacts, if any, that they may have had on mammalian megafauna. Also key to this story is the extinction of this and other hominins during the mid to late Pleistocene. Hominins such as *Homo luzonensis* and *Homo floresiensis* were endemic island species whose demise may match other insular extinction records. The record of *Homo sapiens* movements through Wallacea begins shortly after these losses, but significant impacts on biotas by modern humans only seem to coincide with the Neolithic and the suite of behavioural and technological advances observed throughout the region. Finally, I will describe new efforts to address the megafaunal data deficit in Australia, through targeted excavations of new types of deposits.https://cassyni-user-files-prod.s3.amazonaws.com/4gqE37r9etwdBttoexFUYE https://cassyni.com/events/VjHHeXTjri5MaeSo63Sfk1/seminar/qa https://cassyni.com/slides/outline/VjHHeXTjri5MaeSo63Sfk1 https://cassyni.com/events/VjHHeXTjri5MaeSo63Sfk1/abstract https://cassyni-user-files-prod.s3.amazonaws.com/TNXojChcDbS5sQ6qnJtYez https://cassyni.com/events/VjHHeXTjri5MaeSo63Sfk1?videoPreview=1 A Case for Space Environmentalismnohttps://cassyni.com/events/VjHHeXTjri5MaeSo63Sfk1?videoPreview=12024-05-16T17:00:00+00:003548.24AIAA JournalHumanity has witnessed an unprecedented expansion into outer space in the past two decades. As we venture further into the cosmos, we must confront the environmental challenges that arise from our activities beyond Earth's atmosphere. In this talk, a case for "Space Environmentalism" is presented to address the need for responsible stewardship of the space environment. This talk highlights the urgency of considering the long-term consequences of our actions in space. Just as we have come to recognize the importance of preserving and protecting Earth's environment, we must extend this environmental consciousness to the space realm. This talk also explores the interplay between space debris, satellite mega-constellations, and the sustainability of future space operations. There is a critical need for proactive space traffic management and responsible space debris mitigation practices to ensure the long-term viability of space activities and safeguard against the cascading effects of collisions in orbit. Thus, the talk continues by discussing the role of space agencies, governments, industry stakeholders, and the scientific community in fostering an environment conducive to responsible space exploration and utilization to underscore the importance of international collaboration and the development of norms, guidelines, and policies that promote sustainable space activities.https://cassyni-user-files-prod.s3.amazonaws.com/TNXojChcDbS5sQ6qnJtYez https://cassyni.com/events/7zkhcSzeYZhwmuAWhx413b/abstract https://cassyni-user-files-prod.s3.amazonaws.com/WDzRr9rTY14ZMzyaXmxmh8 https://cassyni.com/events/9yM7oBakJPvhscSk4uuwU9/seminar/qa https://cassyni.com/slides/outline/9yM7oBakJPvhscSk4uuwU9 https://cassyni.com/events/9yM7oBakJPvhscSk4uuwU9/abstract https://cassyni-user-files-prod.s3.amazonaws.com/6CwBjyXhfDo5xEoj3mLasp https://cassyni.com/events/9yM7oBakJPvhscSk4uuwU9?videoPreview=1 Weak scattering in phononic crystalsnohttps://cassyni.com/events/9yM7oBakJPvhscSk4uuwU9?videoPreview=12024-04-23T13:00:00+00:003831.04MetaMATIn recent decades, there has been a significant advancement in the field of phononic crystals, thanks to the development of innovative techniques for controlling waves in complex media. One area of particular interest involves materials comprising a host medium with an array of point scatterers. Hyperuniform and stealth disordered materials are especially noteworthy, as they enable the identification of point scatterers that mitigate scattering within a certain frequency range while exhibiting heterogeneity in another range. The Born hypothesis plays a crucial role in connecting the design of hyperuniform materials to wave propagation characteristics. In this seminar, we will delve into a comprehensive methodology for modeling various types of scatterers in 1D waveguides. Furthermore, we will establish the mathematical correlation between the point distribution and propagation properties to ensure that we are dealing with weak scattering phenomena. To validate this methodology, we will present numerical examples and provide physical interpretations for the mathematical findings.https://cassyni-user-files-prod.s3.amazonaws.com/6CwBjyXhfDo5xEoj3mLasp https://cassyni.com/events/62dsNRAcdsEuZmF3Zcg5Nd/seminar/qa https://cassyni.com/slides/outline/62dsNRAcdsEuZmF3Zcg5Nd https://cassyni.com/events/62dsNRAcdsEuZmF3Zcg5Nd/abstract https://cassyni-user-files-prod.s3.amazonaws.com/ULrFHpqran6vLQpTJD366S https://cassyni.com/events/62dsNRAcdsEuZmF3Zcg5Nd?videoPreview=1 Rebuilding Marine Lifenohttps://cassyni.com/events/62dsNRAcdsEuZmF3Zcg5Nd?videoPreview=12024-06-06T08:00:00+00:003256.92Springer Nature Sustainable Development Goals ProgrammeIn support of World Ocean Day on June 8th 2024, we are pleased to be hosting Prof Carlos M. Duarte, Distinguished Professor of Marine Science. Prof Duarte's presentation "Rebuilding Marine Life" will be followed by a Q&A session chaired by Editors Éva Lörinczi and Greta Hedley-Miller, with the opportunity for the audience to ask questions. Abstract: Hunting, overfishing, habitat loss and pollution have led to a loss of about half of the ocean´s natural capital. However, the ocean remains resilient and able to recover within one human generation, by 2050, if we simultaneously activate seven wedges for recovery. For the first time, the world leaders have agreed on a regenerative approach to ocean conservation, but the investments required to rebuild marine life far exceed those available todate. A new regenerative blue economy, which generates wealth while investing in healthy oceans is required to achieve the goal of a healthy ocean, particularly as the time window to achieve this goal is narrow and rapidly closing. https://cassyni-user-files-prod.s3.amazonaws.com/ULrFHpqran6vLQpTJD366S https://cassyni.com/events/KMdyZYMqEjXAESh2sGfc9b/abstract https://cassyni-user-files-prod.s3.amazonaws.com/7qDfZSzrdeRVuTUU4WgRrW https://cassyni.com/events/169puahNFHhtAfXhZ8y5eV/seminar/qa https://cassyni.com/slides/outline/169puahNFHhtAfXhZ8y5eV https://cassyni.com/events/169puahNFHhtAfXhZ8y5eV/abstract https://cassyni-user-files-prod.s3.amazonaws.com/LEZTwnqcCBY5Vp8yTuqz1U https://cassyni.com/events/169puahNFHhtAfXhZ8y5eV?videoPreview=1 Algorithm and solver developmentnohttps://cassyni.com/events/169puahNFHhtAfXhZ8y5eV?videoPreview=12024-06-11T14:00:00+00:006887.92Nektar++ Development TeamFirst session on the algorithm and solver developments within Nektar++ Framework. The session comprises the following four talks 1. Towards fast and robust incompressible flow simulations with Nektar++ 2. Lower-order refined preconditioning for spectral/hp element methods for complex, 3D geometries 3. Progress on an efficient discontinuous Galerkin incompressible Navier-Stokes solver 4. Implementation of the ALE method for implicit compressible solver in Nektar++https://cassyni-user-files-prod.s3.amazonaws.com/LEZTwnqcCBY5Vp8yTuqz1U https://cassyni.com/slides/outline/3ZPr8zvzSaUNXc1G6psiNR https://cassyni.com/events/3ZPr8zvzSaUNXc1G6psiNR/abstract https://cassyni-user-files-prod.s3.amazonaws.com/4H2XRiFGdc2Bd4Yk5mwrkE https://cassyni.com/events/3ZPr8zvzSaUNXc1G6psiNR?videoPreview=1 PySINDy: A Python Library for Model Discoverynohttps://cassyni.com/events/3ZPr8zvzSaUNXc1G6psiNR?videoPreview=12020-06-20T14:00:00+00:00736.04Brunton LabPySINDy: A Python package for the sparse identification of nonlinear dynamical systems from datahttps://cassyni-user-files-prod.s3.amazonaws.com/4H2XRiFGdc2Bd4Yk5mwrkE https://cassyni.com/events/HtDzbTD6aDTifUDhiiEpZj/seminar/qa https://cassyni.com/slides/outline/HtDzbTD6aDTifUDhiiEpZj https://cassyni.com/events/HtDzbTD6aDTifUDhiiEpZj/abstract https://cassyni-user-files-prod.s3.amazonaws.com/P1HrkLugSccey3BDFgGz5k https://cassyni.com/events/HtDzbTD6aDTifUDhiiEpZj?videoPreview=1 Introduction to the 11th international Biometals webinars, Reprograming the immune microenvironment with iron, Discovering the Quantitative Inorganic Phenotypes of Cells in Health and Disease: A Multidisciplinary Approach to Elemental Mapping in Biologynohttps://cassyni.com/events/HtDzbTD6aDTifUDhiiEpZj?videoPreview=12025-01-07T14:00:00+00:005998.04BioMetalsHemolysis occurs in wide-spread pathological conditions, such as genetic disease, infection, pregnancy complications or during medical interventions such as cardiopulmonary bypass (CPB) with heart-lung-machines. The resulting large amounts of free hemoglobin (Hb) and heme in the circulation overwhelm endogenous scavengers such as haptoglobin (Hp), hemopexin (Hpx) and transferrin (Tf). My presentation will focus on (1) how unbound hemoglobin, heme and iron exert vasculo-toxic and pro-inflammatory effects by activating endothelial and immune cells in mouse models and patients with hemoglobinopathies. These findings highlight a potential therapeutic benefit of iron/haem scavanging therapies in these conditions. (2) how during intravascular hemolysis, the clearance of hemolysis products from the circulation by reticuloendothelial macrophages causes an inflammatory response that damages neighboring cell types. (3) how iron accumulation in tumor associated macrophages by treatment with super-paramagnetic iron oxide nanoparticles can be utilized to reprogram the tumor microenvironment and reduce lung cancer relapse Recent insights from across the biomedical research community have uncovered new inorganic chemistry that regulates or disrupts key events in developmental and reproductive biology, cancer cell proliferation, autoimmune disease, neurodegenerative disease and host pathogen interactions. Indeed, these emerging inorganic phenotypes have established the quantitative requirements and temporal fluctuations in normal and disease states including precise zinc regulation in gamete maturation and fertilization across species. To better understand the mechanisms underlying these processes at the cellular and molecular level, and to extend the concept of a ‘quantitative inorganic phenotype’ an NIGMS-supported center for Quantitative Elemental Mapping for the Life Sciences (QE-Map) was established four years ago. This team has been collaborating with teams across to the globe to accelerate the development and application of quantitative element imaging and analysis technologies. The overarching goals of QE-MAP team are to (a) develop routine methods for the accurate analysis and mapping of inorganic elements from the single cell to the tissue level; b) to overcome current limitations of Laser Ablation ICP-MS and X-ray Fluorescence Microscopy XFM technologies; c) disseminate optimal methods for robust data acquisition, calibration and standardization of quantitative data; and d) to develope workflows and software that allows co-registration of images obtained from allied mapping methods (i.e. immunohistochemistry, MALDI etc). Using examples from several Driving Biological Projects in the QE-Map consortium, this presentation provides an overview of quantitative 2D element mapping approaches and will highlight how inherent limitations are being overcome as these technologies become more widely available. DBP teams send samples to the Quantitative Bio Element Analysis and Mapping (QBEAM), a core facility at MSU which includes two ESI bioImage266 laser ablation microscopes interfaced with Tofwerk/Thermo mass spec instruments (LA-ICP-TOF-MS). Other instruments include an Agilent triple-quad 8900 QQQ-ICP-MS for bulk analysis, a combustion analyzer, ICP-OES and Zeiss Axioscan instruments for imaging and analysis of elements from carbon through the rare earth elements. We anticipate that this cross-disciplinary team science effort will facilitate the broad application of label-free, quantitative inorganic phenotype analysis at the single cell and tissue level leading to new biological understanding of health and disease.https://cassyni-user-files-prod.s3.amazonaws.com/P1HrkLugSccey3BDFgGz5k https://cassyni.com/slides/outline/Xhr5idXxDBN287vqqdELHj https://cassyni.com/events/Xhr5idXxDBN287vqqdELHj/abstract https://cassyni-user-files-prod.s3.amazonaws.com/2GeM5Cmi9KTt4CawbeQyaW https://cassyni.com/events/Xhr5idXxDBN287vqqdELHj?videoPreview=1 Unsteady and Transient applications of Pressure-Sensitive Paintnohttps://cassyni.com/events/Xhr5idXxDBN287vqqdELHj?videoPreview=12023-06-09T12:00:00+00:002597.92UK Fluids NetworkPressure-sensitive paint is a promising and ever growing aerodynamic measurement tool which is finding new applications in many different areas. Unsteady applications have yielded fantastic insights into spatially varying transient phenomenon such as buffet. This talk describes approaches for unsteady and transient applications of PSP from data processing and physical set up perspectives.https://cassyni-user-files-prod.s3.amazonaws.com/2GeM5Cmi9KTt4CawbeQyaW https://cassyni.com/events/24wpwciTsi93ZZvmJvwEsw/abstract https://cassyni-user-files-prod.s3.amazonaws.com/31veUQxNknxGkNwV83kZyx https://cassyni.com/slides/outline/CwD7xex1XnKX5qknvUAvpm https://cassyni.com/events/CwD7xex1XnKX5qknvUAvpm/abstract https://cassyni-user-files-prod.s3.amazonaws.com/2qRTY9ANHpYLV2vYLByez2 https://cassyni.com/events/CwD7xex1XnKX5qknvUAvpm?videoPreview=1 Quasi-Bessel equations: existence and hyper-dimensionalitynohttps://cassyni.com/events/CwD7xex1XnKX5qknvUAvpm?videoPreview=12023-04-20T15:00:00+00:003547.32Journal of Mathematical SciencesWe introduce fractional quasi-Bessel equations and construct their existence theory in the class of fractional series solutions. In order to find the parameters of the series, we derive the characteristic equation, which is surprisingly independent of the terms with non-matching parameters 𝜉𝑖 ≠ 𝛼𝑖 . As a direct corollary, the method allows to analyze quasi-Euler and constant-coefficient equations and is applicable to the existence result for elliptic-like PDEs with fractional Cauchy-Euler operator. We also arrive at a hyper-dimensionality phenomenon for certain fractional differential equations possessing "too many" linearly independent solutions. The theoretical findings are justified computationally. The results are obtained jointly with L. Boyadjiev and J. Slepoi.https://cassyni-user-files-prod.s3.amazonaws.com/2qRTY9ANHpYLV2vYLByez2 https://cassyni.com/events/FQT9C5Bdj561SnEMUA5ZYh/seminar/qa https://cassyni.com/slides/outline/FQT9C5Bdj561SnEMUA5ZYh https://cassyni.com/events/FQT9C5Bdj561SnEMUA5ZYh/abstract https://cassyni-user-files-prod.s3.amazonaws.com/93dqarkWx32JHRN1xkBtiA https://cassyni.com/events/FQT9C5Bdj561SnEMUA5ZYh?videoPreview=1 Promotion Decisions and the Adoption of Explicit Potential Assessmentnohttps://cassyni.com/events/FQT9C5Bdj561SnEMUA5ZYh?videoPreview=12024-03-14T22:00:00+00:004439.6SACLIn this study, we leverage the transformation of a performance management system that shifts from only providing a performance rating to also providing an explicit assessment of potential. While performance measures enable organizations to evaluate an employee’s past performance, they provide limited information regarding the employee’s potential to perform in a prospective job that requires a different skill set. Consequently, firms are gradually moving towards the incorporation of explicit potential assessments in their annual appraisal process to evaluate the employee’s promotability to a different task environment. Our data access allows us to provide fundamental evidence on the effectiveness of a performance management system that adopted the explicit assessment of potential. We find that, on average, the potential assessment system is less effective in identifying candidates suitable for promotion to roles in a different, more complex task environment, thereby contributing to the occurrence of the Peter Principle. We subsequently identify variation in supervisors’ evaluation quality as an important source of the Peter Principle. Paper, click [here](https://web.tresorit.com/l/STFSD#Y-HQ35j7u801uOpWALepHA) https://cassyni-user-files-prod.s3.amazonaws.com/93dqarkWx32JHRN1xkBtiA https://cassyni.com/events/BwuusHexesDNR5vnpVhc1s/seminar/qa https://cassyni.com/slides/outline/BwuusHexesDNR5vnpVhc1s https://cassyni.com/events/BwuusHexesDNR5vnpVhc1s/abstract https://cassyni-user-files-prod.s3.amazonaws.com/YZ7pzQtdksEGCnWevLUPdQ https://cassyni.com/events/BwuusHexesDNR5vnpVhc1s?videoPreview=1 The digital divide in access to broadband internet and mental healthcarenohttps://cassyni.com/events/BwuusHexesDNR5vnpVhc1s?videoPreview=12024-01-31T17:00:00+00:002932.56Nature Mental HealthTelemedicine has greatly improved mental healthcare access worldwide, particularly following the COVID-19 pandemic. However, the growing reliance on broadband internet-based mental healthcare raises concerns surrounding telemedicine’s accessibility in communities already facing barriers in seeking mental health information and care. This study aims to (1) correspond access to broadband internet with access to several mental health resources and (2) quantify the association between social determinants of health and broadband access in the United States. For each of 3,138 US counties, we collected data for the percentage of households without broadband access, the density of various mental healthcare services, urbanization level, and percentage of households with an income below the poverty line. Two-sample t tests and two-proportion z tests were used to substantiate the association between broadband access and mental health resource availability, while multivariate linear regressions were performed to quantify the association between broadband internet access and mental health resource availability, while controlling for urbanicity level and poverty rate. Finally, geographical trends in broadband access and mental health services were visualized in QGIS. US counties with reduced broadband access have lower average densities of mental healthcare physicians, non-physician mental health practitioners, inpatient psychiatric and substance abuse treatment facilities, and outpatient facilities (P < 0.001). Moreover, counties with reduced broadband access are nearly three times as likely to have no mental health physicians and no outpatient facilities, over twice as likely to have no non-physician mental health practitioners, and nearly twice as likely to have no psychiatric/ substance abuse hospitals (P < 0.001). These results suggest that expanding access to mental health resources in rural, low-income, and medically underresourced communities is necessary in light of their reduced access to both broadband internet and mental healthcare services.https://cassyni-user-files-prod.s3.amazonaws.com/YZ7pzQtdksEGCnWevLUPdQ https://cassyni.com/slides/outline/HP5BVSHctGEVgyCz7gswbs https://cassyni.com/events/HP5BVSHctGEVgyCz7gswbs/abstract https://cassyni-user-files-prod.s3.amazonaws.com/GEBcLcbYtYYHYA5QHhnpyC https://cassyni.com/events/HP5BVSHctGEVgyCz7gswbs?videoPreview=1 Electrochemical Measurement of the Electronic Structure of Low-Dimensional Materialsnohttps://cassyni.com/events/HP5BVSHctGEVgyCz7gswbs?videoPreview=12024-04-26T13:00:00+00:003334.56Electrochimica ActaThe quantum-rate theory defines a quantum mechanical rate that complies with the Planck–Einstein relationship, permitting the study of relativistic quantum electrodynamics phenomena intrinsically related to the perturbation of the density-of-states. The electronic structure of graphene and inorganic quantum dots (within colloidal sizes) embedded in an electrolyte environment can be measured on this basis. The electronic structure measured using quantum-rate spectroscopy (QRS) is in good agreement with that measured through angle-resolved photoemission spectroscopy (ARPES) or calculated via computational density-functional theory (DFT) methods for the case of graphene and Scanning Tunneling Microscopy and Spectroscopy (STM/STS) in the case of inorganic quantum dots. Electrochemical QRS has evident experimental advantages over ARPES or STM/STS methods. For instance, QRS enables obtaining the electronic structure of graphene at room temperature and in an electrolyte environment, whereas ARPES requires low temperature and ultrahigh-vacuum conditions. Furthermore, QRS can operate in situ using a hand-held, inexpensive piece of equipment, whereas ARPES necessarily requires expensive and cumbersome apparatus.https://cassyni-user-files-prod.s3.amazonaws.com/GEBcLcbYtYYHYA5QHhnpyC https://cassyni.com/slides/outline/QnoFBgzVU8YLBYjT5Zjg1s https://cassyni.com/events/QnoFBgzVU8YLBYjT5Zjg1s/abstract https://cassyni-user-files-prod.s3.amazonaws.com/hSHyABMaNPb7kxPmxLhTt https://cassyni.com/events/QnoFBgzVU8YLBYjT5Zjg1s?videoPreview=1 Syndrome of Inappropriate Antidiuresis (SIAD)nohttps://cassyni.com/events/QnoFBgzVU8YLBYjT5Zjg1s?videoPreview=12023-12-06T16:00:00+00:003168.0Imperial College Renal and Transplant CentreNo abstracthttps://cassyni-user-files-prod.s3.amazonaws.com/hSHyABMaNPb7kxPmxLhTt https://cassyni.com/slides/outline/DRtM7y7RNboLuJkJiaHtzy https://cassyni.com/events/DRtM7y7RNboLuJkJiaHtzy/abstract https://cassyni-user-files-prod.s3.amazonaws.com/XtNCiBqcN9S5vy1e9jv73k https://cassyni.com/events/DRtM7y7RNboLuJkJiaHtzy?videoPreview=1 Discrete-decision-variable Simulation Optimization in Operational Researchnohttps://cassyni.com/events/DRtM7y7RNboLuJkJiaHtzy?videoPreview=12022-04-06T10:00:00+00:003171.56Data-Centric Engineering Journal“Simulation optimization” (occasionally “optimization via simulation”) is the term that operational researchers use to describe optimizing the output performance measures of a dynamic stochastic simulation with respect to some controllable design or decision variables, sometimes subject to stochastic constraints. Often the decision variables are discrete-valued, such as the number of agents to assign to each hour of the day in a call center, or the reorder points for various products in a supply chain. Discrete decision variables present a particular challenge for simulation optimization, and how the problem is attacked depends greatly on the number of feasible solutions, dimension of the decision variables, and computational cost of running the simulation. In this talk I will describe extremes: simulating EVERY feasible solution in a statistically and computationally efficient way when the simulations are relatively cheap; and simulating a very small fraction of the feasible solutions strategically when the simulation is computationally expensive. The former draws on ideas from ranking & selection, while the latter is based on Bayesian optimization, but in each case with a new twist driven by the number of feasible solutions being large.https://cassyni-user-files-prod.s3.amazonaws.com/XtNCiBqcN9S5vy1e9jv73k https://cassyni.com/slides/outline/PKL1zLoyztd2Ee1K7xQSeH https://cassyni.com/events/PKL1zLoyztd2Ee1K7xQSeH/abstract https://cassyni-user-files-prod.s3.amazonaws.com/CwrweUJMYqabX2jNeU358S https://cassyni.com/events/PKL1zLoyztd2Ee1K7xQSeH?videoPreview=1 Superconducting devices with ferromagnetic insulating GdNnohttps://cassyni.com/events/PKL1zLoyztd2Ee1K7xQSeH?videoPreview=12024-05-23T09:00:00+00:004104.6School of Chemical and Physical SciencesA thin Superconductor (S) proximity coupled to a Ferromagnetic Metal (FM) is an experimentally well studied system showcasing intriguing phenomena such as an oscillatory T_c with FM thickness, zero to pi transitions in S/FM/S Josephson Junctions (JJs), and the possibility of generation of spin polarized Cooper pairs using conventional s-wave superconductors [1,2]. However, the proximity coupling of a Ferromagnetic Insulator to a superconductor is relatively less explored. The primary feature of proximity coupling in FI/S systems is the appearance of an effective exchange field in a thin S layer, which is distinctly different from that of the stray field emanating out of the FI layer [3]. Most studies of FI/S systems have thus far been performed with various Europium chalcogenides. In this talk, I will discuss few superconducting devices using ferromagnetic insulator – GdN, which has been developed at the Quantum Materials and Devices Laboratory at IIT Bombay. The first is an FI/S bilayer, which is demonstrated as a system that allow application and tuning of local magnetic fields [4]. The second device is a large mesa type S/FI/S JJ; where a combination of barrier magnetization and magnetization due to junction self-current, leads to a zero magnetic field non-reciprocal Josephson effect (Josephson Diode). A non-volatile Josephson memory with reasonably high characteristic voltage is also demonstrable in such large magnetic JJs with GdN tunnel barrier. https://cassyni-user-files-prod.s3.amazonaws.com/CwrweUJMYqabX2jNeU358S https://cassyni.com/events/WEQUdusL9JNojSztVPyNny/seminar/qa https://cassyni.com/slides/outline/WEQUdusL9JNojSztVPyNny https://cassyni.com/events/WEQUdusL9JNojSztVPyNny/abstract https://cassyni-user-files-prod.s3.amazonaws.com/5DdyecEenJgqw3TH7b5oWN https://cassyni.com/events/WEQUdusL9JNojSztVPyNny?videoPreview=1 Some recent results on graphs with a high degree of symmetrynohttps://cassyni.com/events/WEQUdusL9JNojSztVPyNny?videoPreview=12024-04-26T01:00:00+00:003259.76The Journal of Algebraic CombinatoricsA graph G is said to be s-set-homogeneous (s-CH) (respectively s-connected-set-homogeneous (s-CSH)) if for any two isomorphic (respectively connected) induced subgraphs of G of order at most s there exists an automorphism of G that sends one to the other. We say that the graph G is s-homogeneous (respectively s-connected homogeneous (s-CH)) if any isomorphism between (respectively connected) induced subgraphs of order at most s extends to an automorphism of the whole graph. In this talk, I will survey some old and new results in this area.https://cassyni-user-files-prod.s3.amazonaws.com/5DdyecEenJgqw3TH7b5oWN https://cassyni.com/events/Wj45gbWrakvrjDXn5qGB4H/abstract https://cassyni-user-files-prod.s3.amazonaws.com/6uW7XQccnbR4hzek8qQAKG https://cassyni.com/slides/outline/RHvSB5Q5kiqnLMHYUvGP4q https://cassyni.com/events/RHvSB5Q5kiqnLMHYUvGP4q/abstract https://cassyni-user-files-prod.s3.amazonaws.com/S4mnHRBKiyrzMY88mfyHiv https://cassyni.com/events/RHvSB5Q5kiqnLMHYUvGP4q?videoPreview=1 AI/ML+Physics Part 1: Choosing what to modelnohttps://cassyni.com/events/RHvSB5Q5kiqnLMHYUvGP4q?videoPreview=12024-02-23T12:00:00+00:002606.04Brunton LabThis video discusses the first stage of the machine learning process: (1) formulating a problem to model. There are lots of opportunities to incorporate physics into this process, and learn new physics by applying ML to the right problem. SLB acknowledges support from the National Science Foundation AI Institute in Dynamic Systems and from The Boeing Company.https://cassyni-user-files-prod.s3.amazonaws.com/S4mnHRBKiyrzMY88mfyHiv https://cassyni.com/slides/outline/FubxJ677R2KERHF55BSSWZ https://cassyni.com/events/FubxJ677R2KERHF55BSSWZ/abstract https://cassyni-user-files-prod.s3.amazonaws.com/7XxNnWpN8yTHZR6kjC8yeN https://cassyni.com/events/FubxJ677R2KERHF55BSSWZ?videoPreview=1 A differentiable programming framework for spin modelsnohttps://cassyni.com/events/FubxJ677R2KERHF55BSSWZ?videoPreview=12024-09-17T12:00:00+00:001945.52Computer Physics CommunicationsWe introduce a novel framework for simulating spin models using differentiable programming, an approach that leverages the advancements in machine learning and computational efficiency. We focus on three distinct spin systems: the Ising model, the Potts model, and the Cellular Potts model, demonstrating the practicality and scalability of our framework in modeling these complex systems. Additionally, this framework allows for the optimization of spin models, which can adjust the parameters of a system by a defined objective function. In order to simulate these models, we adapt the Metropolis-Hastings algorithm to a differentiable programming paradigm, employing batched tensors for simulating spin lattices. This adaptation not only facilitates the integration with existing deep learning tools but also significantly enhances computational speed through parallel processing capabilities, as it can be implemented on different hardware architectures, including GPUs and TPUs.https://cassyni-user-files-prod.s3.amazonaws.com/7XxNnWpN8yTHZR6kjC8yeN https://cassyni.com/slides/outline/Ay7uqFds2SnD2BXj4hjSnR https://cassyni.com/events/Ay7uqFds2SnD2BXj4hjSnR/abstract https://cassyni-user-files-prod.s3.amazonaws.com/6qnasCWwHwXUN94Uss58sG https://cassyni.com/events/Ay7uqFds2SnD2BXj4hjSnR?videoPreview=1 The Cytokinin Receptors in Rice Have Overlapping and Specific Roles in Vegetative and Reproductive Developmentnohttps://cassyni.com/events/Ay7uqFds2SnD2BXj4hjSnR?videoPreview=12024-06-06T18:25:00+00:00671.16New Phytologist Foundation The diverse functions of the phytohormone cytokinin and its signaling pathway have been well studied in the model organism *Arabidopsis thaliana*. Although several studies have observed direct connections between cytokinin levels and yield, less is known about cytokinin signaling in the model monocot Oryza sativa, or rice. To elucidate the function of cytokinin in rice, we utilized CRISPR to generate a suite of cytokinin signaling mutants. In rice, four Histidine Kinases (HKs) serve as cytokinin receptors: HK3, HK4, HK5, and HK6. We phenotyped mutant rice lines containing all different combinations of null HK alleles to elucidate the specific functions of each receptor. With respect to vegetative development, HK3 and HK5 are most important for shoot elongation, whereas HK4 and HK6 are most important for cytokinin perception in the roots. Furthermore, HK6 alone displayed defects in trichome development. The redundancy of these pairs of HKs was also true for panicle development, as *hk3* and *hk5* mutants showed defects in secondary branch formation, whereas *hk4* and *hk6* mutants showed the strongest reduction in spikelet filling. Overall, the HK receptors show a combination of specificity and redundancy to control development at all stages of growth.https://cassyni-user-files-prod.s3.amazonaws.com/6qnasCWwHwXUN94Uss58sG https://cassyni.com/events/MLmDvEjmeRLMhAXGNNcn6Z/abstract https://cassyni-user-files-prod.s3.amazonaws.com/WvPnsXJmh1WZcqXm7Xuut2 https://cassyni.com/slides/outline/71xhaQyYv9GnNzmSxA5qp9 https://cassyni.com/events/71xhaQyYv9GnNzmSxA5qp9/abstract https://cassyni-user-files-prod.s3.amazonaws.com/376o3dEhkDrQYMsvPzsz6S https://cassyni.com/events/71xhaQyYv9GnNzmSxA5qp9?videoPreview=1 PCAN Podcast Episode 3: Dr Ferriero and local treatments in mCRPCnohttps://cassyni.com/events/71xhaQyYv9GnNzmSxA5qp9?videoPreview=12024-02-25T14:00:00+00:001859.6Research Seminars by Springer NatureNo abstracthttps://cassyni-user-files-prod.s3.amazonaws.com/376o3dEhkDrQYMsvPzsz6S https://cassyni.com/slides/outline/aq44trn67Bhz8XDMF63ph https://cassyni.com/events/aq44trn67Bhz8XDMF63ph/abstract https://cassyni-user-files-prod.s3.amazonaws.com/NsuCPwAKgWFXA22dQ96THp https://cassyni.com/events/aq44trn67Bhz8XDMF63ph?videoPreview=1 The Io torus and highlights from 10 years operation of the Hisaki missionnohttps://cassyni.com/events/aq44trn67Bhz8XDMF63ph?videoPreview=12024-07-09T14:00:00+00:001640.16MOP2024The Io plasma torus (IPT), located in the Jovian inner magnetosphere (6-8 RJ from the planet), is filled with electrons and heavy ions such as sulfur and oxygen, a significant portion of which originates from the volcanoes on Io. The IPT serves as a crucial region connecting the primary plasma source (Io) with the middle and outer magnetosphere, where highly dynamic phenomena occur. Understanding the behavior of plasma in the IPT is essential for discussing the plasma dynamics in the whole Jovian magnetosphere. A comprehensive understanding of the IPT can be achieved through spectral analysis of ion emissions, which are generated by electron impact excitation. This method is called 'plasma diagnostics.' The emission lines from ions in the IPT are mainly in the extreme ultraviolet (EUV) region. Therefore, EUV spectroscopic data are important for the study of Jupiter’s inner magnetosphere. Hisaki, an Earth-orbiting spacecraft equipped with the extreme ultraviolet spectroscope EXCEED, has been providing high-resolution spectra of the IPT from 2013 to 2023. Here we present a summary of 10 years of operations for IPT spectroscopic observation by Hisaki. Ion and electron density variation, the relationship between the IPT and auroras, and responses to volcanic activity will be discussed.https://cassyni-user-files-prod.s3.amazonaws.com/NsuCPwAKgWFXA22dQ96THp https://cassyni.com/slides/outline/GQHBTQGXFqo4EkEasHZQgm https://cassyni.com/events/GQHBTQGXFqo4EkEasHZQgm/abstract https://cassyni-user-files-prod.s3.amazonaws.com/FZBa4QXgFoHDzoxmwR9Gea https://cassyni.com/events/GQHBTQGXFqo4EkEasHZQgm?videoPreview=1 Polynomials on Banach Latticesnohttps://cassyni.com/events/GQHBTQGXFqo4EkEasHZQgm?videoPreview=12021-05-20T14:00:00+00:002775.92Positivity Journal, SpringerNatureHomogeneous polynomials are vital in the study of analytic functions on Banach spaces, as they are the components of the Taylor series that represent the functions locally. As most of the classical Banach spaces are Banach lattices, it is natural to work with polynomials that are coherent with the lattice structure. Thus, we study regular homogeneous polynomials, as they have a modulus that is a positive homogeneous polynomial. We demonstrate some applications, to analysis on Banach spaces with an unconditional basis, and to the radius of analyticity in a real Banach space. We also look at an application to the computation of the radius of convergence of power series on Banach lattices. We then consider the class of orthogonally additive polynomials, particularly on spaces of continuous functions, where some interesting geometric phenomena are seen.https://cassyni-user-files-prod.s3.amazonaws.com/FZBa4QXgFoHDzoxmwR9Gea https://cassyni.com/events/8zZ7m9ZefyVYUi3gK7wnEh/abstract https://cassyni-user-files-prod.s3.amazonaws.com/7TNECehzrS4L8MMwfcxmG2 https://cassyni.com/events/JsYpoT22rVVbUhk77Feb1F/seminar/qa https://cassyni.com/slides/outline/JsYpoT22rVVbUhk77Feb1F https://cassyni.com/events/JsYpoT22rVVbUhk77Feb1F/abstract https://cassyni-user-files-prod.s3.amazonaws.com/EsLvPrw4eSgjWfemfiqhCr https://cassyni.com/events/JsYpoT22rVVbUhk77Feb1F?videoPreview=1 In memory of the distinguished logician, philosopher and political activist V.A. Yankov (1935 - 2024)nohttps://cassyni.com/events/JsYpoT22rVVbUhk77Feb1F?videoPreview=12024-08-14T14:00:00+00:005464.04Logica UniversalisThis session consists of four short presentations: **A brief overview of the biography of V.A. Yankov** (Kirill Yankov) **Yankov’s contributions to propositional logic** (Alex Citkin) The talk I will present two most significant contributions by V.A. Yankov: the Yankov Logic and Yankov characteristic formulas. **V.A. Yankov’s Contribution to the History and Philosophy of Mathematics** (Ioannis Vandoulakis) The talk will present three significant contributions of V.A. Yankov to the History and Philosophy of Mathematics: 1) By inviting A.A. Markov, the founder of the Russian school of constructivism and his teacher, to respond to Heyting’s fictional persons “Class,” “Form,” “Int,” “Pragm,” and “Sign,” which represent classical mathematics, formalism, intuitionism, pragmatism and significism, respectively, when he edited the Russian translation of Heyting’s Intuitionism. This response is the only historical record of Markov’s views on Brouwer’s intuitionistic mathematics and logic. 2) His appraisal of A.S. Esenin-Vol’pin’s program of ultra-intuitionistic foundations of mathematics stated in his commentary published in a volume dedicated to Esenin-Vol’pin by Finn and Daniel’ in 1999, in which he also included three less known and hardly accessible works of Esenin-Vol’pin [1967, 1971, 1999] devoted to the theory of modalities, deontic logic, the theory of disputes and the logic of trust. 3) His novel interpretation of the rise of mathematics and mathematical proof in ancient Greece. It is formulated by considering the development of the early Greek philosophers’ ontological conceptions. **V.A. Yankov’s existential research program** (Tatiana Denisova) In this talk, I will discuss the least known and, at the same time, the most controversial research program proposed by V.A. Yankov, namely his philosophical conception of the existential history of human thought, which is based on the idea of reconsidering the WHOLE history of human thought from an existential perspective. That means that the whole history of philosophy, regardless of the immediate subject of philosophers’ reasoning, is required to be reinterpreted as a history of “existential types”, i.e., as a history of the changes in the human’s self-understanding and the correlated changes in human’s understanding of the general picture of the world. https://cassyni-user-files-prod.s3.amazonaws.com/EsLvPrw4eSgjWfemfiqhCr https://cassyni.com/events/Pp2sGHVHF52csoTT7jMajP/seminar/qa https://cassyni.com/slides/outline/Pp2sGHVHF52csoTT7jMajP https://cassyni.com/events/Pp2sGHVHF52csoTT7jMajP/abstract https://cassyni-user-files-prod.s3.amazonaws.com/X87fJ2KtsHf1JPemDtTrGN https://cassyni.com/events/Pp2sGHVHF52csoTT7jMajP?videoPreview=1 New ways of workingnohttps://cassyni.com/events/Pp2sGHVHF52csoTT7jMajP?videoPreview=12024-10-08T08:15:00+00:001601.52North West London Kidney CareNo abstracthttps://cassyni-user-files-prod.s3.amazonaws.com/X87fJ2KtsHf1JPemDtTrGN https://cassyni.com/events/RndHT25NzuFNyWjgUhDX9w/seminar/qa https://cassyni.com/slides/outline/RndHT25NzuFNyWjgUhDX9w https://cassyni.com/events/RndHT25NzuFNyWjgUhDX9w/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Dq4RBuz1GaF8rd884DRr1U https://cassyni.com/events/RndHT25NzuFNyWjgUhDX9w?videoPreview=1 Pyrolytic Syntheses of N-Doped Solid Base Metal Catalysts for the Production of Aminesnohttps://cassyni.com/events/RndHT25NzuFNyWjgUhDX9w?videoPreview=12024-09-25T10:00:00+00:002050.36Tetrahedron Chem and Tetrahedron Green ChemThis presentation delves into advanced catalyst design, with a particular emphasis on heteroatom doping. The supported hydrogenation catalysts exhibited significant activity in both reductive amination and nitroarene reduction, applicable in batch and continuous-flow processes. Preparation involved applying air-stable, non-precious, molecularly defined precursors onto support materials via wet impregnation, followed by pyrolytic activation. A strong focus was placed on material recyclability. Detailed structural and thermal analyses, conducted using TGA, XPS, EDX, and STEM techniques, provided deep insights into surface morphology and behavior under varying conditions.https://cassyni-user-files-prod.s3.amazonaws.com/Dq4RBuz1GaF8rd884DRr1U https://cassyni.com/slides/outline/UFsJgSK1CC1sLTDF2P89ss https://cassyni.com/events/UFsJgSK1CC1sLTDF2P89ss/abstract https://cassyni-user-files-prod.s3.amazonaws.com/LqfqMMb1ZmcfTqW4kF3ERC https://cassyni.com/events/UFsJgSK1CC1sLTDF2P89ss?videoPreview=1 Quantification of gut bacterial strains following fecal transplantationnohttps://cassyni.com/events/UFsJgSK1CC1sLTDF2P89ss?videoPreview=12021-09-14T11:00:00+00:00559.2Microbiome Virtual International ForumFecal Microbiota Transplantation (FMT) while successful, lacks a quantitative identification of the discrete bacterial strains that stably engraft in recipients, and their association with clinical outcomes. Using the largest collection of more than 1,000 unique bacterial strains cultured from a combination of 22 FMT donors and recipients with recurrent Clostridioides difficile infection (rCDI), we develop an approach Strainer for detection and tracking of bacterial strains from metagenomic sequencing data. On application to 13 FMT interventions, we detect stable and high engraftment of 71% of microbiota strains in recipients at even 5-years post-transplant, a remarkably durable therapeutic from a single administration. Although ~80% of the original pre-FMT recipient strains were eliminated by the FMT, those strains that remain persist even 5 years later, along with newer strains acquired from the environment. The precise quantification of donor bacterial strain engraftment in recipients independently explained (precision 100%, recall 95%) the clinical outcomes of relapse or success after both initial and repeat-FMT. We next apply this to the largest successful FMT trial for patients with Ulcerative Colitis (FOCUS study), and found both overall and specific high engraftment of certain bacterial strains and species in patients that achieved the primary endpoint of steroid-free clinical remission with endoscopic remission or response. We provide a list of bacterial species and strains that are present in multiple donors and consistently engraft in recipients over time, for use in Live Biotherapeutic Products (LBP) as a safer alternative to FMT. Our framework can enable the systematic evaluation of different FMT and LBP study designs by quantification of strain engraftment in recipients.https://cassyni-user-files-prod.s3.amazonaws.com/LqfqMMb1ZmcfTqW4kF3ERC https://cassyni.com/slides/outline/53PuWJuLZfz7qXHQCaJBGR https://cassyni.com/events/53PuWJuLZfz7qXHQCaJBGR/abstract https://cassyni-user-files-prod.s3.amazonaws.com/HzwcLRck3PS9XNpPjW8w4r https://cassyni.com/events/53PuWJuLZfz7qXHQCaJBGR?videoPreview=1 Engineering Genetically Intractable Bacteria: Targeted elimination of restriction-modification motifs in plasmid sequences with the SyngenicDNA Tool Generator (SyToGen)nohttps://cassyni.com/events/53PuWJuLZfz7qXHQCaJBGR?videoPreview=12021-11-09T13:00:00+00:0064.8Microbiome Virtual International Forum The vast majority of bacteria that can be grown in a laboratory remain genetically intractable, beyond the power of genetics for elucidating function or engineering for human use. Inherent diversity of genetic defenses, primarily Restriction-Modification (RM) systems, across bacterial species and individual strains remains a fundamental barrier to human-made DNA constructs during genetic engineering of bacteria. Previously, we described an approach to evade RM systems through the creation of SyngenicDNA; de-novo synthesized DNA sequences that are precisely altered to achieve epigenetic compatibility with a desired bacterial host and to prevent RM defense activation upon artificial transformation. SyngenicDNA-based genetic tools have increased transformation efficiencies by several orders of magnitude, yet still require manual ad-hoc sequence alterations for their generation. To remove the need for manual introduction of site-specific DNA alterations in silico, and to improve the accessibility, speed of generation, and reproducibility of SyngenicDNA, we introduce the SyngenicDNA Tool Generator (SyToGen). SyToGen is a computational workbench designed to assist users who work with bacteria that are currently genetically intractable. The software adheres to the manual workflow for generating SyngenicDNA, namely target identification, in silico tool assembly and sequence adaptation, but rapidly and reproducibly provides users with RM-silent DNA templates for de novo synthesis and assembly. SyToGen output plasmid sequences retain the form and functionality of the original genetic tool, but are now uniquely re-designed at the DNA level to bypass RM barriers and operate within the specific bacterium of interest.https://cassyni-user-files-prod.s3.amazonaws.com/HzwcLRck3PS9XNpPjW8w4r https://cassyni.com/slides/outline/QJi6Rbeh5tWShGSxuqUYub https://cassyni.com/events/QJi6Rbeh5tWShGSxuqUYub/abstract https://cassyni-user-files-prod.s3.amazonaws.com/LU1tt4m3pWeGzzjn82VvAJ https://cassyni.com/events/QJi6Rbeh5tWShGSxuqUYub?videoPreview=1 Host-microbe interactions in the vaginal microenvironmentnohttps://cassyni.com/events/QJi6Rbeh5tWShGSxuqUYub?videoPreview=12024-06-11T10:00:00+00:00764.0Microbiome Virtual International Forum This talk will summarize current efforts of the Patras lab to establish preclinical models of the vaginal microenvironment and assess the functional role of the vaginal microbiota in the context of a variety of host states including health, pregnancy, and diabetes.https://cassyni-user-files-prod.s3.amazonaws.com/LU1tt4m3pWeGzzjn82VvAJ https://cassyni.com/slides/outline/7Wdvjj8xkxkcCTkxkGCozM https://cassyni.com/events/7Wdvjj8xkxkcCTkxkGCozM/abstract https://cassyni-user-files-prod.s3.amazonaws.com/DgQgkbHLDSEFN3HXpPzoTU https://cassyni.com/events/7Wdvjj8xkxkcCTkxkGCozM?videoPreview=1 Reporting guidelines for human microbiome research: the STORMS checklistnohttps://cassyni.com/events/7Wdvjj8xkxkcCTkxkGCozM?videoPreview=12022-01-11T14:00:00+00:0061.56Microbiome Virtual International Forum The particularly interdisciplinary nature of human microbiome research makes the organization and reporting of results spanning epidemiology, biology, bioinformatics, translational medicine and statistics a challenge. Commonly used reporting guidelines for observational or genetic epidemiology studies lack key features specific to microbiome studies. Therefore, a multidisciplinary group of microbiome epidemiology researchers adapted guidelines for observational and genetic studies to culture-independent human microbiome studies, and also developed new reporting elements for laboratory, bioinformatics and statistical analyses tailored to microbiome studies. The resulting tool, called Strengthening The Organization and Reporting of Microbiome Studies (STORMS), is composed of a 17-item checklist organized into six sections that correspond to the typical sections of a scientific publication, presented as an editable table for inclusion in supplementary materials. The STORMS checklist provides guidance for concise and complete reporting of microbiome studies that will facilitate manuscript preparation, peer review, and reader comprehension of publications and comparative analysis of published results. Link to OA paper: https://www.nature.com/articles/s41591-021-01552-xhttps://cassyni-user-files-prod.s3.amazonaws.com/DgQgkbHLDSEFN3HXpPzoTU https://cassyni.com/events/Smx7f1tKHBHFnkG5sEdHbT/seminar/qa https://cassyni.com/slides/outline/Smx7f1tKHBHFnkG5sEdHbT https://cassyni.com/events/Smx7f1tKHBHFnkG5sEdHbT/abstract https://cassyni-user-files-prod.s3.amazonaws.com/7wzWnCSEuHV577LvP9JftJ https://cassyni.com/events/Smx7f1tKHBHFnkG5sEdHbT?videoPreview=1 From scalar to tensor finite elementsnohttps://cassyni.com/events/Smx7f1tKHBHFnkG5sEdHbT?videoPreview=12024-09-19T12:00:00+00:004073.04MOX Laboratory - Department of MathematicsIn the history of finite elements, the earliest Lagrange finite elements, consisted of scalar-valued functions. To approximate fluxes, vector-valued finite elements with continuous normal (n) components across element interfaces, or n-continuous elements, were developed later. The finite element toolkit was then supplemented by t-continuous vector-valued Nedelec elements with continuous tangential (t) components, now routinely used for Maxwell equations. Although these elements were developed separately, today we understand them together as fitting into a cochain subcomplex of a de Rham complex of Sobolev spaces. Other tensor-valued finite elements are now being viewed with increasing interest and they form the main subject of this talk. The earliest of these consists of matrix-valued functions whose normal-normal (nn) component varies continuously across element interfaces: these are the nn-continuous matrix fields of the Hellan-Herrmann-Johnson element. More recently, nt-continuous matrix-valued finite elements were developed to approximate viscous stress in incompressible flows: they have continuous shear, or normal-tangential (nt) components. To add to this picture, matrix-valued elements with continuous tangential-tangential (tt) components, called Regge elements, are finding increasing utility: they are key to approximating the metric tensor of Riemannian manifolds. This talk delves into the details of these developments. How does one connect these disparate developments with nn-, nt-, and tt-continuous matrix finite elements? This does not appear to be as easy as the previous synthesis of vector-valued elements by the de Rham complex. The spaces in de Rham complexes are connected by fundamental first-order differential operators (grad, curl, and div in three dimensions), all derived from a single definition of the exterior derivative. In contrast, what is natural for the above-mentioned tensor finite elements are other second-order differential operators. We conclude grazing the frontiers of our understanding on potentially unifying connections. This initiative is part of the “Ph.D. Lectures” activity of the project "Departments of Excellence 2023-2027" of the Department of Mathematics of Politecnico di Milano. This activity consists of seminars open to Ph.D. students, followed by meetings with the speaker to discuss and go into detail on the topics presented at the talk. https://cassyni-user-files-prod.s3.amazonaws.com/7wzWnCSEuHV577LvP9JftJ https://cassyni.com/slides/outline/446hQwcHgksyAmTQ6bprTX https://cassyni.com/events/446hQwcHgksyAmTQ6bprTX/abstract https://cassyni-user-files-prod.s3.amazonaws.com/AM2rgyfYFbVdkbJkJ7uyZY https://cassyni.com/events/446hQwcHgksyAmTQ6bprTX?videoPreview=1 LotuS2: An ultrafast and highly accurate tool for amplicon sequencing analysisnohttps://cassyni.com/events/446hQwcHgksyAmTQ6bprTX?videoPreview=12022-03-08T13:00:00+00:00420.0Microbiome Virtual International Forum Amplicon sequencing is an established and cost-efficient method for profiling microbiomes. However, many available tools to process this data require both bioinformatics skills and high computational power to process big datasets. Furthermore, there are only few tools that allow for long read amplicon data analysis. To bridge this gap, we developed the LotuS2 (Less OTU Scripts 2) pipeline, enabling user-friendly, resource friendly, and versatile analysis of raw amplicon sequences. In LotuS2, six different sequence clustering algorithms as well as extensive pre- and post-processing options allow for flexible data analysis by both experts, where parameters can be fully adjusted, and novices, where defaults are provided for different scenarios. We benchmarked three independent gut and soil datasets, where LotuS2 was on average 29 times faster compared to other pipelines – yet could better reproduce the alpha- and beta-diversity of technical replicate samples. Further benchmarking a mock community with known taxa composition showed that, compared to the other pipelines, LotuS2 recovered a higher fraction of correctly identified genera and species (98% and 57%, respectively). At ASV/OTU level, precision and F-score were highest for LotuS2, as was the fraction of correctly reconstructed 16S sequences. In conclusion, LotuS2 is a lightweight and user-friendly pipeline that is fast, precise and streamlined. High data usage rates and reliability enable high-throughput microbiome analysis in minutes.https://cassyni-user-files-prod.s3.amazonaws.com/AM2rgyfYFbVdkbJkJ7uyZY https://cassyni.com/slides/outline/ERiPPJCJuNWPhGkY7hmk93 https://cassyni.com/events/ERiPPJCJuNWPhGkY7hmk93/abstract https://cassyni-user-files-prod.s3.amazonaws.com/SGuyKPmL1FR4XtykhBRggn https://cassyni.com/events/ERiPPJCJuNWPhGkY7hmk93?videoPreview=1 Genome-centric analysis of short and long read metagenomes reveals uncharacterized microbiome diversity in Southeast Asiansnohttps://cassyni.com/events/ERiPPJCJuNWPhGkY7hmk93?videoPreview=12022-09-13T10:00:00+00:00868.04Microbiome Virtual International Forum Despite extensive efforts to address it, the vastness of uncharacterized ‘dark matter’ microbial genetic diversity can impact short-read sequencing based metagenomic studies. Population-specific biases in genomic reference databases can further compound this problem. Leveraging advances in long-read and Hi-C technologies, we deeply characterized 109 gut microbiomes from three ethnicities in Singapore to comprehensively reconstruct 4,497 medium and high-quality metagenome assembled genomes, 1,708 of which were missing in short-read only analysis and with less than 28 N50 improvement. Species-level clustering identified 70 (less than 10% of total) novel gut species out of 685, improved reference genomes for 363 species (53% of total), and discovered 3,413 strains that are unique to these populations. Among the top 10 most abundant gut bacteria in our study, one of the species and less than 80% of all strains were not represented in existing databases. Annotation of biosynthetic gene clusters (BGCs) uncovered more than 27,000 BGCs with a large fraction (36-88%) not represented in current databases, and with several unique clusters predicted to produce bacteriocins that could significantly alter microbiome community structure. These results reveal the significant uncharacterized gut microbial diversity in Southeast Asian populations and highlight the utility of hybrid metagenomic references for bioprospecting and disease-focused studies.https://cassyni-user-files-prod.s3.amazonaws.com/SGuyKPmL1FR4XtykhBRggn https://cassyni.com/slides/outline/EvMzRyqqLq4Sh3HRi94YQM https://cassyni.com/events/EvMzRyqqLq4Sh3HRi94YQM/abstract https://cassyni-user-files-prod.s3.amazonaws.com/TWXyw6t96toG39TK3vVGmU https://cassyni.com/events/EvMzRyqqLq4Sh3HRi94YQM?videoPreview=1 In-depth insights into cervicovaginal microbial communities and hrHPV infections using high-resolution microbiome profilingnohttps://cassyni.com/events/EvMzRyqqLq4Sh3HRi94YQM?videoPreview=12022-10-18T15:00:00+00:0059.64Microbiome Virtual International Forum The cervicovaginal microbiome (CVM) correlates with women's cervical health, and variations in its composition are associated with high-risk human papillomavirus (hrHPV) infection outcomes. Cervicovaginal microbes have been grouped into five community state types (CSTs) based on microbial community composition and abundance. However, studying the impact of CSTs in health and disease is challenging because the current sequencing technologies have limited confident discrimination between closely related and yet functionally different bacterial species. Circular probe-based RNA sequencing (ciRNAseq) achieves high-resolution microbiome profiling and therefore provides in-depth and unambiguous knowledge about the composition of the CVM. Based on ciRNAseq profiling of a large cohort of cervical smears (n = 541), we here define subgroups of CSTs I, III, and IV based on intra-CST differences with respect to abundances of Lactobacillus acidophilus (CSTs I-A vs. I-B and CSTs III-A vs. III-B), Lactobacillus iners (CSTs I-A vs. I-B and CSTs III-A vs. III-B), and Megasphaera genomosp type 1 (CSTs IV-A vs. IV-B). Our results further support the existence of subgroups of CST IV-C that are dominant for non-Lactobacillus species and have intermediate microbial diversity. We also show that CST V is associated with uninfected conditions, and CST IV-A associates with hrHPV-induced cervical disease. In conclusion, we characterized new subdivisions of cervicovaginal CSTs, which may further advance our understanding of women's cervical health and hrHPV-related progression to disease.https://cassyni-user-files-prod.s3.amazonaws.com/TWXyw6t96toG39TK3vVGmU https://cassyni.com/slides/outline/9VELvTj4WnyNJB3C7E4kQu https://cassyni.com/events/9VELvTj4WnyNJB3C7E4kQu/abstract https://cassyni-user-files-prod.s3.amazonaws.com/QRUxPq67MnLKrS2JTbrsu8 https://cassyni.com/events/9VELvTj4WnyNJB3C7E4kQu?videoPreview=1 Exposure to environmental stressors decreases the resilience of river microbial communities towards invasion by foreign resistant bacterianohttps://cassyni.com/events/9VELvTj4WnyNJB3C7E4kQu?videoPreview=12023-01-16T10:00:00+00:00728.04Microbiome Virtual International Forum The release of wastewater treatment plant effluents into rivers exposes the river microbiome to a high load of antibiotic resistant bacteria (ARB) along with complex mixtures of abiotic pollutants acting as stressors. To understand the proliferation of antimicrobial resistance (AMR) it is crucial to determine the factors that govern invasion of ARB into the river microbiome. Consequently, we here aim at elucidating how the resilience of the resident microbial communities against invasion by foreign ARB is affected by co-released stressors. To achieve this, we grew natural microbial biofilms on glass slides in rivers for one month. The biofilms were then transferred to laboratory, recirculating flume systems and exposed to a single pulse of a model resistant invader bacterium (E. coli) either in presence or absence of stress induced by Cu2+. The invasion dynamics of E. coli into the biofilms were then monitored for 14 days. Despite an initially successful introduction of E. coli into the biofilms, independent of the imposed stress, over time the invader perished in absence of stress. However, under stress the invading strain successfully established and proliferated in the biofilms. Noteworthy, the increased establishment success of the invader coincided with a loss in microbial community diversity under stress conditions, likely due to additional niche space becoming available for the invader. In conclusion, we demonstrate that the intrinsic resilience of the river microbiome towards invasion by ARB is strongly linked with maintaining diversity and that co-exposure to stressors that disrupt community diversity and structure increases long-term invasion success. Link to OA paper: https://www.biorxiv.org/content/10.1101/2022.11.19.517188v1https://cassyni-user-files-prod.s3.amazonaws.com/QRUxPq67MnLKrS2JTbrsu8 https://cassyni.com/slides/outline/KNE3xmBShJyRJAjcuMmZBT https://cassyni.com/events/KNE3xmBShJyRJAjcuMmZBT/abstract https://cassyni-user-files-prod.s3.amazonaws.com/HsthXmmQYU12hLs4iECuBc https://cassyni.com/events/KNE3xmBShJyRJAjcuMmZBT?videoPreview=1 Preterm birth is associated with xenobiotics and predicted by the vaginal metabolomenohttps://cassyni.com/events/KNE3xmBShJyRJAjcuMmZBT?videoPreview=12023-02-15T12:00:00+00:00584.04Microbiome Virtual International Forum Spontaneous preterm birth (sPTB) is a leading cause of maternal and neonatal morbidity and mortality, yet its prevention and early risk stratification are limited. Previous investigations have suggested that vaginal microbes and metabolites may be implicated in sPTB. Here we performed untargeted metabolomics on 232 second-trimester vaginal samples, 80 from pregnancies ending preterm. We find multiple associations between vaginal metabolites and subsequent preterm birth, and propose that several of these metabolites, including diethanolamine and ethyl glucoside, are exogenous. We observe associations between the metabolome and microbiome profiles previously obtained using 16S ribosomal RNA amplicon sequencing, including correlations between bacteria considered suboptimal, such as Gardnerella vaginalis, and metabolites enriched in term pregnancies, such as tyramine. We investigate these associations using metabolic models. We use machine learning models to predict sPTB risk from metabolite levels, weeks to months before birth, with good accuracy (area under receiver operating characteristic curve of 0.78). These models, which we validate using two external cohorts, are more accurate than microbiome-based and maternal covariates-based models (area under receiver operating characteristic curve of 0.55–0.59). Our results demonstrate the potential of vaginal metabolites as early biomarkers of sPTB and highlight exogenous exposures as potential risk factors for prematurity. Link to paper: https://www.nature.com/articles/s41564-022-01293-8https://cassyni-user-files-prod.s3.amazonaws.com/HsthXmmQYU12hLs4iECuBc https://cassyni.com/slides/outline/XiSA7rMZfkpHBqyRsiLHKb https://cassyni.com/events/XiSA7rMZfkpHBqyRsiLHKb/abstract https://cassyni-user-files-prod.s3.amazonaws.com/EYD2DEUs9f5kCMCrJrs9w4 https://cassyni.com/events/XiSA7rMZfkpHBqyRsiLHKb?videoPreview=1 Steamed broccoli sprouts alleviate gut inflammation and retain gut microbiota against DSS-induced dysbiosisnohttps://cassyni.com/events/XiSA7rMZfkpHBqyRsiLHKb?videoPreview=12023-06-21T12:00:00+00:00544.04Microbiome Virtual International Forum Inflammatory Bowel Diseases (IBD) are devastating conditions of the gastrointestinal tract with limited treatments, and dietary intervention may be effective, affordable, and safe for managing symptoms. Ongoing research has identified inactive compounds in broccoli sprouts, like glucoraphanin, and that mammalian gut microbiota play a role in metabolizing it to the anti-inflammatory sulforaphane. The objectives were to identify biogeographic location of participating microbiota and correlate that to health outcomes. We fed specific pathogen free C57BL/6 mice either a control diet or a 10% steamed broccoli sprout diet, and gave a three-cycle regimen of 2.5% dextran sodium sulfate (DSS) in drinking water over a 40-day experiment to simulate chronic, relapsing ulcerative colitis. We monitored body weight, fecal characteristics, fecal lipocalin, and sequenced bacterial communities from the contents and mucosa in the jejunum, cecum, and colon. Mice fed the broccoli sprout diet while receiving DSS performed better than mice fed the control diet while receiving DSS for all disease parameters, including significantly more weight gain (2-way ANOVA, p lower than 0.05), lower Disease Activity Index scores (2-way ANOVA, p lower than 0.001), and higher bacterial richness in all gut locations (linear regression model, p lower than 0.01 for all locations measured). Bacterial communities were assorted by gut location except in the mice receiving the control diet and DSS treatment (Beta-diversity, ANOVA, p lower than 0.05 for each). Importantly, our results suggested that broccoli sprout feeding completely abrogated the effects of DSS on gut microbiota, as bacterial communities were similar between mice receiving broccoli sprouts with and without DSS. Spatially resolved microbial communities provide greater insight when investigating host-microbe interactions. Here, we show that a 10% broccoli sprout diet protects mice from the negative effects of dextran sodium sulfate induced colitis, that colitis erases biogeographical patterns of bacterial communities in the gut, and that the cecum is not likely to be a significant contributor to colonic bacteria of interest in the DSS mouse model of ulcerative colitis. Link to OA paper: https://www.biorxiv.org/content/10.1101/2023.01.27.522641v2https://cassyni-user-files-prod.s3.amazonaws.com/EYD2DEUs9f5kCMCrJrs9w4 https://cassyni.com/events/5Y58fd4kQVTwezGuzgR9Sd/seminar/qa https://cassyni.com/slides/outline/5Y58fd4kQVTwezGuzgR9Sd https://cassyni.com/events/5Y58fd4kQVTwezGuzgR9Sd/abstract https://cassyni-user-files-prod.s3.amazonaws.com/DKM9Rz2zsvzfmmhi2cvU38 https://cassyni.com/events/5Y58fd4kQVTwezGuzgR9Sd?videoPreview=1 Tunable magnetism in rare-earth nitride solid solutionsnohttps://cassyni.com/events/5Y58fd4kQVTwezGuzgR9Sd?videoPreview=12024-12-12T08:00:00+00:004027.04School of Chemical and Physical SciencesRecent attempts to cation-substitute the rare-earth nitrides have led to the ability to tune their magnetism. This supports attempts to avail them in low-temperature electronics, as there is a versatility associated with the control of such parameters as the saturation magnetisation and the coercive field. Moreover, XMCD measurements elucidate the mechanism by which the magnetisation can be controlled and this suggests the existence of compositions at which the magnetisation and the angular momentum can be compensated (pushed to zero as a function of composition). In this talk I will discuss the early measurements of Gd$_x$Sm_{1-x}$N and how they show these properties, how one can locate the compensation points using lab-based techniques, and the devices the one can build for low temperature electronics using this tunability. https://cassyni-user-files-prod.s3.amazonaws.com/DKM9Rz2zsvzfmmhi2cvU38 https://cassyni.com/slides/outline/YCoY2ErE5c77Q4JXXa8PYy https://cassyni.com/events/YCoY2ErE5c77Q4JXXa8PYy/abstract https://cassyni-user-files-prod.s3.amazonaws.com/J3UwzFkNk3SgNJMnHrZyGA https://cassyni.com/events/YCoY2ErE5c77Q4JXXa8PYy?videoPreview=1 Experimental insight into nonlinear dynamics of asymmetric weakly coupled micromachined resonatorsnohttps://cassyni.com/events/YCoY2ErE5c77Q4JXXa8PYy?videoPreview=12025-06-24T10:00:00+00:00673.12NODYSThis work experimentally analyses a novel tunable asymmetric AlN-Piezoelectric weakly coupled resonator consisting of cantilever and bridge resonators. As tuning the applied electrothermal voltage, the system exhibits two veering points and a buckling point, showing great potential for sensing applications. The results demonstrate that the 1st global mode dominated by the cantilever remains unaltered while the 2nd global mode dominated by the bridge varies with increasing electrothermal voltage, proving the great potential for multi-sensing applications. At both veering points, the system energy confinement on bridge-dominated mode and nonlinear mode exchange could be observed. The system nonlinearity changes from highly hardening behaviour to highly softening behaviour at the buckling point where strong harmonic contributions were demonstrated, which could be exploited as a trigger signal in alarming sensor design.https://cassyni-user-files-prod.s3.amazonaws.com/J3UwzFkNk3SgNJMnHrZyGA https://cassyni.com/slides/outline/Qo5UKz9MVjobe27cyQWm6u https://cassyni.com/events/Qo5UKz9MVjobe27cyQWm6u/abstract https://cassyni-user-files-prod.s3.amazonaws.com/FaGYsU2dx7cEtTK9BQViSa https://cassyni.com/events/Qo5UKz9MVjobe27cyQWm6u?videoPreview=1 Study on Bicycle Self-Stabilization Mechanism by Dynamic-and-Data-Driven Surrogate Modellingnohttps://cassyni.com/events/Qo5UKz9MVjobe27cyQWm6u?videoPreview=12025-06-24T10:00:00+00:00963.32NODYSBicycle self-stabilization is an intriguing phenomenon that remains not fully understood. While it is known that the inherent self-stabilization mechanism arises from the spontaneous behavior of turning towards a fall (TTF), the driving force behind the spontaneous TTF remains unclear. To enable a comprehensive quantitative analysis, we develop a dynamic-and-data-driven bicycle surrogate model based on the structure derived from bicycle symmetries and model reduction. The coefficients of the surrogate dynamic equations reveal how the gravity-induced overturning torque can be balanced by a stabilizing torque caused by the TTF behavior and why the TTF occurs spontaneously. Our analysis shows that the nonholonomic constraints on bicycle motion play a critical role in generating the stabilizing and driving torques of the TTF. Additionally, we reveal that the nonholonomic-constraint-related gyroscopic moment induces stiffness and damping effects in the surrogate model. Consequently, the TTF behavior autonomously performs feedback control to generate the balancing torque, while stiffness and damping enhance the bicycle system's stability. Finally, we explore the influence of bicycle geometric parameters on self-stabilization, discovering limit-cycle motions for specific configurations. Results indicate that while straight-line motion is unstable for negative fork angles, stability is achieved in a limited positive range. Furthermore, for certain positive fork angles, the system exhibits stable limit-cycle motions rather than stable straight-line motion. This novel phenomenon highlights how system nonlinearities improve resilience by enabling stable oscillatory behaviors before instability arises. These findings provide valuable insights into the mechanisms of self-stabilization and lay a foundation for future studies on bicycle dynamics and design.https://cassyni-user-files-prod.s3.amazonaws.com/FaGYsU2dx7cEtTK9BQViSa https://cassyni.com/slides/outline/TGKVZQNyh2a5zxbBX6RPpq https://cassyni.com/events/TGKVZQNyh2a5zxbBX6RPpq/abstract https://cassyni-user-files-prod.s3.amazonaws.com/9mehaSBDnz76Er6aCLcXYS https://cassyni.com/events/TGKVZQNyh2a5zxbBX6RPpq?videoPreview=1 A Review of Chaotic Behavior in High Temperature Superconducting Magnetic Levitation Systemsnohttps://cassyni.com/events/TGKVZQNyh2a5zxbBX6RPpq?videoPreview=12025-06-24T11:00:00+00:00442.36NODYSHigh-temperature superconducting (HTSC) magnetic levitation (maglev) systems are gaining attention for their unique electromagnetic properties and potential applications, including transportation, space docking, and energy storage. This review examines recent studies on the dynamic characteristics of HTSC maglev systems, focusing on how disturbances like temperature variations, structural imperfections, and system configurations can induce chaotic vibrations. Key factors include rapid changes in temperature and current density, structural defects, and the nonlinear electromagnetic responses. Understanding these dynamics is crucial for optimizing the performance and reliability of superconducting maglev systems. The review also discusses the implications of these findings and potential directions for future research.https://cassyni-user-files-prod.s3.amazonaws.com/9mehaSBDnz76Er6aCLcXYS https://cassyni.com/slides/outline/812vkk9WaAyDENYgbnq68d https://cassyni.com/events/812vkk9WaAyDENYgbnq68d/abstract https://cassyni-user-files-prod.s3.amazonaws.com/At7JvyP9nGMK151aLoGiGW https://cassyni.com/events/812vkk9WaAyDENYgbnq68d?videoPreview=1 An Integrate 3-DOF Adjustable QZS Vibration Isolation System with High-Order Stabilitynohttps://cassyni.com/events/812vkk9WaAyDENYgbnq68d?videoPreview=12025-06-24T11:00:00+00:001022.24NODYSThe aim of this study is to design an integrated vibration isolation system based on buckling beams, with adjustable quasi-zero-stiffness (QZS) along three axes (torsional stiffness about the horizontal and axes and translational stiffness in the vertical axis). The design concept of the isolation system is first proposed, and the three degrees of freedom(3-DoF) coupled third-order nonlinear governing equations of the overall isolation system are established by the Galerkin method. The feasibility of the system is further verified by finite element analysis and experiments on a prototype system.https://cassyni-user-files-prod.s3.amazonaws.com/At7JvyP9nGMK151aLoGiGW https://cassyni.com/slides/outline/FuSDcK1nzrksYR4fMmoniq https://cassyni.com/events/FuSDcK1nzrksYR4fMmoniq/abstract https://cassyni-user-files-prod.s3.amazonaws.com/YDcF8ai7wJUQTLvZRd2AZt https://cassyni.com/events/FuSDcK1nzrksYR4fMmoniq?videoPreview=1 Revisiting simple Alfven waves in Hall (extended) MHD Emergence of a Singular Branchnohttps://cassyni.com/events/FuSDcK1nzrksYR4fMmoniq?videoPreview=12025-01-16T16:00:00+00:003465.64Journal of Plasma PhysicsIt is well appreciated that the Hall term constitutes a singular perturbation to magnetohydrodynamics (MHD). Although, singular solutions and their importance has found much attention in equilibrium HMHD, it has not been appreciated, at least explicitly, that the elementary Alfvenic motions also undergo propound transformations in HMHD (extended MHD). Apart from modifying the conventional MHD spectrum, the Hall current induces a distinct and new branch consisting of purely circularly polarized waves that may become the representative shear wave. This branch - Alfven H- with no MHD counterpart, is the direct expression of the singular perturbation. Alfven H has profound effects on both coherent -nonlinear and turbulent evolution of the system. The robustness of Alfven H is tested by examining its fate in more realistic systems- when, for instance, the equilibrium magnetic field is sheared.https://cassyni-user-files-prod.s3.amazonaws.com/YDcF8ai7wJUQTLvZRd2AZt https://cassyni.com/slides/outline/AUJa6nu2Apfo9YpRkrozjP https://cassyni.com/events/AUJa6nu2Apfo9YpRkrozjP/abstract https://cassyni-user-files-prod.s3.amazonaws.com/TH8CfkEsYiwP4FDDR9KAqk https://cassyni.com/events/AUJa6nu2Apfo9YpRkrozjP?videoPreview=1 Structure formation and transport in magnetized fusion plasmasnohttps://cassyni.com/events/AUJa6nu2Apfo9YpRkrozjP?videoPreview=12024-07-25T15:00:00+00:002817.12Journal of Plasma PhysicsTransport in magnetized fusion plasmas provides an interesting example of how collective behaviors in complex systems lead to structure formation and self-organization. This occurs because transport is dominated by fluctuations that are excited at the system microscales, characterized by the typical width of charged particle orbits in the strong equilibrium magnetic field. These fluctuations can provide nonlinear feedback on the plasma equilibrium profiles, i.e., on the system macroscales. Most importantly, however, fluctuation spectra and transport phenomena also yield to structure formation on the mesoscales, which are intermediate between the micro- and the macro-scales and can be due to both linear wave packet propagation in the slowly evolving and weakly non-uniform plasma medium as well as to nonlinear couplings. Meanwhile, high temperature, weakly collisional, reactor-relevant fusion plasmas can have velocity space distributions, which deviate from local thermodynamic equilibrium. Thus, transport and structure formation in magnetized fusion plasmas must be necessarily described in the phase space, and studying their nonlinear dynamics requires advanced kinetic treatments of thermal as well as supra-thermal components, including realistic geometries and plasma non-uniformities. This work presents the main findings of a comprehensive approach that enables predicting and describing the long time scale behavior of reactor relevant magnetized fusion plasmas as nonlinear equilibria, which evolve self-consistently with fluctuation spectra as well as sources/collisions. Examples of applications to cases of practical interest are also given, focusing on simplified paradigmatic cases for illustrating the workflow of the Advanced Transport model for Energetic Particle (ATEP) code. In particular, the case of neutral beam injected particles in ITER will be shown, which are redistributed under the action of Coulomb collisions and a fixed amplitude toroidal Alfv´en eigenmode.https://cassyni-user-files-prod.s3.amazonaws.com/TH8CfkEsYiwP4FDDR9KAqk https://cassyni.com/events/AxxB9UYYcHDr9KMKMJ6nzh/abstract https://cassyni-user-files-prod.s3.amazonaws.com/MqzZAE86igqyvqdRQX5GtN https://cassyni.com/events/Ht4Fug7nA3uMnc3J1JcAn1/abstract https://cassyni-user-files-prod.s3.amazonaws.com/GuWWhPerL7JxXjv5Q3NHAE https://cassyni.com/events/LMJH96MQMLfr9YWrYzWoVw/abstract https://cassyni-user-files-prod.s3.amazonaws.com/KNkXvotUXQ5StgPdwjGutA https://cassyni.com/events/UkKYviMKp85qJssKcqqriq/abstract https://cassyni.com/slides/outline/XDZaA8ax1QrKfpLtAXkVSm https://cassyni.com/events/XDZaA8ax1QrKfpLtAXkVSm/abstract https://cassyni-user-files-prod.s3.amazonaws.com/SQiQJCNbf73zJjqtmker5U https://cassyni.com/events/XDZaA8ax1QrKfpLtAXkVSm?videoPreview=1 Maximal Energy Release and the Rules of Rearrangementnohttps://cassyni.com/events/XDZaA8ax1QrKfpLtAXkVSm?videoPreview=12021-12-02T16:00:00+00:002725.24Journal of Plasma PhysicsThroughout plasma physics, we are often interested in processes through which kinetic energy is transferred out of a distribution of particles. Examples of these processes include wave-particle interactions (for instance, the amplification of a wave) as well as the growth of turbulent internal modes. Some particle distributions are more prone to these energy transfers than others. Of interest is the maximal possible energy that can be liberated from a distribution function by wave-particle interactions with constraints on the nature of the interaction. These constraints might be that the waves can only rearrange the 6D phase space, or that they must conserve adiabatic invariants, or that instead they can only act to diffuse particles. This talk will trace the development of these ideas, starting in the 1960s. Among the developments that we will cover is the recent and surprising result that, with enough fine-tuning, the energy recoverable from diffusive processes can reach the energy recoverable from entropy-conserving processes.https://cassyni-user-files-prod.s3.amazonaws.com/SQiQJCNbf73zJjqtmker5U https://cassyni.com/events/Tm2LqM4GwCyge83KWsNXuw/abstract https://cassyni.com/events/6X9MqxEi4XANWN49eKAPm7/abstract https://cassyni.com/events/71nxtdtEVyiRW8b3EkTC2R/abstract https://cassyni.com/slides/outline/BSZjxs8H9PW4NWnfYxHeb7 https://cassyni.com/events/BSZjxs8H9PW4NWnfYxHeb7/abstract https://cassyni-user-files-prod.s3.amazonaws.com/64Mqi1bZi8ssAu9eVewszn https://cassyni.com/events/BSZjxs8H9PW4NWnfYxHeb7?videoPreview=1 Efficacy and Safety of Rivaroxaban in Neonatal Catheter-related Thrombosis: A Single-center Retrospective Study of 122 Casesnohttps://cassyni.com/events/BSZjxs8H9PW4NWnfYxHeb7?videoPreview=12025-10-16T09:45:51+00:00470.48Society for Pediatric Interventional Radiology## Introduction To systematically evaluate the clinical efficacy of rivaroxaban in treating neonatal catheter-related thrombosis (CRT) and analyze risk factors affecting treatment outcomes. ## Materials and Methods Clinical data of 122 neonatal CRT patients treated with rivaroxaban from March 2022 to October 2024 at our Hospital were retrospectively analyzed. The primary outcome was complete thrombus resolution rate. Multivariate logistic regression was used to analyze risk factors affecting treatment efficacy. ## Results Among 122 patients, the complete thrombus resolution rate was 71.31% (87/122) after 6 weeks of anticoagulation, which significantly increased to 88.52% (108/122) after extending to 3 months (p<0.01). Multivariate logistic regression analysis showed that chemotherapy (OR=5.48, 95%CI: 1.04-28.73, P<0.05) and difficult catheter placement (OR=12.53, 95%CI: 3.13-50.22, P<0.05) were independent risk factors affecting 3-month anticoagulation efficacy. No anticoagulation-related bleeding or other complications were observed during the study period. ## Discussion Retrospective data suggest that rivaroxaban is safe and effective in treating neonatal catheter-related thrombosis, with a higher complete thrombus resolution rate observed at 3 months compared to 6 weeks of anticoagulation therapy. Chemotherapy and difficult catheter placement were identified as independent risk factors affecting treatment efficacy. However, these findings require validation through multi-center, prospective, randomized controlled trials.https://cassyni-user-files-prod.s3.amazonaws.com/64Mqi1bZi8ssAu9eVewszn https://cassyni.com/slides/outline/NKixe3rBh1Ksxw6jqaDb7j https://cassyni.com/events/NKixe3rBh1Ksxw6jqaDb7j/abstract https://cassyni-user-files-prod.s3.amazonaws.com/PmQdSnmPpGXxz4vgfUataa https://cassyni.com/events/NKixe3rBh1Ksxw6jqaDb7j?videoPreview=1 12 Labours Platform 3: Measuring the geometry of the human body surfacenohttps://cassyni.com/events/NKixe3rBh1Ksxw6jqaDb7j?videoPreview=12022-11-15T23:00:00+00:002037.92Auckland Bioengineering InstituteThe development of personalised healthcare models to facilitate home-based healthcare will enable new strategies for treating chronic disease. Such personalised models that incorporate the physiological systems of the human body require a common 3D coordinate system in which different organ systems can be positioned and linked together. A common coordinate system for the human body requires a dataset of accurate whole-body geometries sufficient to characterise the population variation. For this purpose, a prototype camera-based 3D imaging system has been developed at the Auckland Bioengineering Institute. Camera-based 3D reconstruction of the external geometry of the body, that is the skin surface, offers a relatively cheap and quick method to measure the body shape of many individuals. This imaging system captures coloured 3D data of the skin surface of individuals in both static and dynamic poses. In this talk I will present the development of this prototype body scanner. I will also discuss an upcoming study in which we plan to image up to 400 New Zealanders to build a database of human models and the possible secondary use of this dataset for other researchers at the Auckland Bioengineering Institute and beyond.https://cassyni-user-files-prod.s3.amazonaws.com/PmQdSnmPpGXxz4vgfUataa https://cassyni.com/slides/outline/CRohpyPZDakr6TATxA4DU9 https://cassyni.com/events/CRohpyPZDakr6TATxA4DU9/abstract https://cassyni-user-files-prod.s3.amazonaws.com/oH7UbqNT5Cd8PMLFrVvKg https://cassyni.com/events/CRohpyPZDakr6TATxA4DU9?videoPreview=1 Biophysics in Africa: Cryogenic electron microscopy is revolutionizing biology: where are we now and the future ahead of usnohttps://cassyni.com/events/CRohpyPZDakr6TATxA4DU9?videoPreview=12024-07-31T06:00:00+00:003331.56Springer Nature Physics CommunityElectron Microscopy under cryogenic temperatures is currently the fastest growing area in structural biology. Advances in instrumentation and software have made it possible for cryoEM to quite sustainably achieve resolutions in the order of 3Å or better for a wide range of biological specimens, without the need of crystallization or large scale protein production. I will review the bases on which this technological revolution has started, where we are now and discuss about the future ahead of us.https://cassyni-user-files-prod.s3.amazonaws.com/oH7UbqNT5Cd8PMLFrVvKg https://cassyni.com/slides/outline/TkurNpzjKmGn4WqZLSE6cd https://cassyni.com/events/TkurNpzjKmGn4WqZLSE6cd/abstract https://cassyni-user-files-prod.s3.amazonaws.com/MEPbixjZR4gPLRkB4FuVNE https://cassyni.com/events/TkurNpzjKmGn4WqZLSE6cd?videoPreview=1 Leveraging OR to build more sustainable, resilient, and equitable communities in Southeast Asianohttps://cassyni.com/events/TkurNpzjKmGn4WqZLSE6cd?videoPreview=12022-09-02T12:30:00+00:003001.16The United Nations Sustainable Development Goals (SDGs) are a universal call to action to end poverty, protect the planet, and improve the lives and prospects of everyone, everywhere. Operational Research has a major role to play in finding solutions to sustainable development challenges and helping the achievement of the SDGs. This talk discusses two projects, funded by the UK Global Challenges Research Fund (GCRF), to build more resilient, egalitarian, and inclusive communities in Southeast Asia. The first project (GCRF-OSIRIS) used OR tools integrated with models and output from the fields of meteorology, hydrology, and social science to minimise the impacts of severe flooding in urban areas of Vietnam. Because flooding disproportionally impacts the lives of women and poor communities, the views and concerns of these vulnerable groups were elicited and taken into account during the model building phase to identify community-responsive flood mitigation solutions. Building on the success of GCRF-OSIRIS, a recent follow-up project (CREST-OR) focused on fostering inclusive OR communities in Cambodia, Indonesia, Laos, Myanmar, and Vietnam by equipping future generations (including women) with the relevant OR expertise needed to tackle a range of sustainable development challenges. The talk will conclude by highlighting additional opportunities for OR to help realise an inclusive and sustainable future for Southeast Asian communities and accelerate progress of the SDG agenda.https://cassyni-user-files-prod.s3.amazonaws.com/MEPbixjZR4gPLRkB4FuVNE https://cassyni.com/slides/outline/GPzxK77fEEXnnGrQySnKbj https://cassyni.com/events/GPzxK77fEEXnnGrQySnKbj/abstract https://cassyni-user-files-prod.s3.amazonaws.com/5CHH75FAkJm6s4JhjvAn94 https://cassyni.com/events/GPzxK77fEEXnnGrQySnKbj?videoPreview=1 Suppression of Resonance in Shallow Cavities. A Case Study in Aerodynamic Flow Controlnohttps://cassyni.com/events/GPzxK77fEEXnnGrQySnKbj?videoPreview=12022-11-16T16:00:00+00:003583.24Department of AeronauticsAircraft noise is a key environmental concern for communities in the proximity of airports. While the engine remains the major source of noise in an aircraft, at low altitude and low speeds a significant role is played by aerodynamic noise generated by airflow over the fuselage. During landing, when the engines operate at reduced power, a prominent source of aerodynamic noise is located at the landing gear bay, due to the occurrence of self-sustained oscillations in a resonant cavity. Suppressions of these oscillations may result in a significant reduction of overall aircraft noise during landing. In this talk, we summarize the research activity of the Gas Dynamics and Turbulence Lab at The Ohio State University that has been devoted to the design and experimental evaluation of model-based feedback controllers for suppressing subsonic cavity resonance. Proper orthogonal decomposition and Galerkin projection techniques were used to obtain a reduced-order model of the flow dynamics from experimental data. The model was made amenable to control design by means of an optimization-based control separation technique, which makes the control input appear explicitly in the equations. An adaptive feedback controller was then employed to suppress the cavity tones from pressure measurements. Experimental results, in qualitative agreement with the theoretical analysis, showed that the controller achieves a significant attenuation of the resonant tone with a redistribution of the energy into other frequencies. The benefits of parameter adaptation over controllers of fixed structure under varying or uncertain flow conditions were also demonstrated experimentally. Finally, an outlook into application of closed-loop strategies for jet noise mitigation is offered.https://cassyni-user-files-prod.s3.amazonaws.com/5CHH75FAkJm6s4JhjvAn94 https://cassyni.com/slides/outline/BTWurGeQqezmPB94xy5Ksb https://cassyni.com/events/BTWurGeQqezmPB94xy5Ksb/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Kh3237GnzNNu83FH2F6dQJ https://cassyni.com/events/BTWurGeQqezmPB94xy5Ksb?videoPreview=1 Application of a variational approach to the computation of forces around a wingnohttps://cassyni.com/events/BTWurGeQqezmPB94xy5Ksb?videoPreview=12022-03-29T14:15:24+00:00977.04Experiments in FluidsIn this paper we present an application of the variational approach, introduced by Quartapelle and Napolitano (AIAA J 21:911–913, 1983) and developed further by Protas et al. (J Comput Phys 159:231–245, 2000), which requires only the velocity fields and its derivatives to determine forces acting on a body. First, the approach is presented and adapted to our 3D test problem. The obtained expression for the hydrodynamic force involves a harmonic function η whose determination is also presented. Then, numerical flow fields obtained with LES are used in order to evaluate the influence of different parameters on the forces and to offer a validation of the proposed approach. This allows us to assess the accuracy of the method and its advantages. Next, a comparison of the proposed variational approach with the momentum equation approach presented by David et al. (2009) is discussed. The momentum equation approach offers a non-intrusive method to determine forces, but requires the pressure field around the object. On the other hand, the variational approach requires the determination of the vorticity field on the surface of the wing, which is not always trivial to obtain with sufficient accuracy, but the computation of the pressure field can be avoided. This paper aims to compare both methods in a practical setting and show their relative advantages and sensitivities to different parameters for a 3D numerical/experimental study of a flow field around a NACA0015 airfoil. To the best of our knowledge, this is the first application of the variational approach in an experimental setting.https://cassyni-user-files-prod.s3.amazonaws.com/Kh3237GnzNNu83FH2F6dQJ https://cassyni.com/slides/outline/JNB2nPyTweregX6n63xJKo https://cassyni.com/events/JNB2nPyTweregX6n63xJKo/abstract https://cassyni-user-files-prod.s3.amazonaws.com/B2CgbYbAUJH1xLbEotCv2A https://cassyni.com/events/JNB2nPyTweregX6n63xJKo?videoPreview=1 Identifying invariant solutions with Nektar++nohttps://cassyni.com/events/JNB2nPyTweregX6n63xJKo?videoPreview=12022-09-13T14:30:00+00:001639.04NEKTAR++Several canonical flows are known to remain stable for arbitrary high values of the Reynolds numbers. In the case of those flows transition to turbulence is the result of the onset of equilibrium states, populating the phase space, rather than a cycle of bifurcations that takes the flow away from its laminar form. Those equilibria solutions influence dynamics of the flow by attracting the solution from the sufficiently perturbed laminar state and along their stable manifolds and then govern the dynamics of the flow evolution by ejecting the solution along the respective unstable trajectories. An important group of invariant states are those that lie on the boundary that separates the laminar and turbulent attraction basins. Such states form relative attractors on the boundary and manifest as simple or relative periodic orbits or travelling waves. Identification of such states is a worthwhile endeavour as it sheds light on the path the flow needs to take in order to cross the laminar-turbulent edge and in principle should allow for the formulation of control strategies with the goal of either accelerating or postponing the transition. In this work we present several Nektar++ based tools designed to aid in the identification of such states.https://cassyni-user-files-prod.s3.amazonaws.com/B2CgbYbAUJH1xLbEotCv2A https://cassyni.com/slides/outline/VESKoSD1bj38CnvohbBzGd https://cassyni.com/events/VESKoSD1bj38CnvohbBzGd/abstract https://cassyni-user-files-prod.s3.amazonaws.com/SXiFAdNgSaWqqQMpX99YJi https://cassyni.com/events/VESKoSD1bj38CnvohbBzGd?videoPreview=1 Flows through Living Roughnessnohttps://cassyni.com/events/VESKoSD1bj38CnvohbBzGd?videoPreview=12022-01-07T16:00:00+00:003857.32Journal of Fluid MechanicsKelp forests, seagrass beds, and coral reefs are among the most productive, bio-diverse, and beautiful of marine ecosystems. Hydrodynamics plays a central role in their function, controlling mass transfer between the organisms and the overlying flow, setting patterns and rates of transport of larvae, and affecting the extent to which the environment (temperature, pH, etc.) in these nearshore systems are different from that of the adjacent ocean. Central to this interplay of physics and ecology is the fact that the resistance to flow provided by kelp plants, seagrasses, or corals is determined by the geometry and density of these “ecosystem architects”, behavior that is described by the dynamics of complex, canopy flows. I will present field observations of these flows drawn from a coral reef in American Samoa, a seagrass bed in Palau, and a kelp forest in Baja. In the first case, drag can be related explicitly to the reef geometry at cm scales. In the second case, drag varies strongly with velocity reflecting the re-configuration of the drag elements due to bending, behavior that can be modeled with some accuracy. In the final case, I will show velocity measurements taken over the span of several years during which time the condition of the kelp forest varied between non-existent and dense. During this time rms depth-averaged velocities varied by a factor of 3, showing the importance of kelp-dependent drag to flow. However, this last case seems substantially more complicated in that drag on flow through a kelp forest is strongly influenced by surface waves, has multiple drag sources, and involves substantial inhomogeneity in the distribution of the kelp plants themselves. Nonetheless, I will present a simplified approach to inferring drag through kelp.https://cassyni-user-files-prod.s3.amazonaws.com/SXiFAdNgSaWqqQMpX99YJi https://cassyni.com/slides/outline/UF97i4uxiovyY36obcifTj https://cassyni.com/events/UF97i4uxiovyY36obcifTj/abstract https://cassyni-user-files-prod.s3.amazonaws.com/VmkLnzv8WChAqJM26tvCUW https://cassyni.com/events/UF97i4uxiovyY36obcifTj?videoPreview=1 Use of High-Order Curved Elements for Direct and Large Eddy Simulation of Flow over Rough Surfacesnohttps://cassyni.com/events/UF97i4uxiovyY36obcifTj?videoPreview=12023-01-19T15:00:00+00:003177.88PyFRIn the present study, the curved element capabilities of a high-order solver are scrutinized for use in scale-resolving simulations regarding roughness. The approach devised not only suggests a plausible way to adopt a body-fitted grid approach as an alternative to immersed boundary method (IBM), but also enables performing LES instead of DNS without under-resolving the roughness. The method is first tested using various polynomial degrees. Then, it is validated against reference DNS-IBM results from a rough channel flow setup having various Reynolds numbers corresponding to the entire roughness range. The results confirm the validity of the new approach. Finally, a highly loaded low-pressure turbine cascade is simulated under LES resolution with and without the roughness patch. Although a rougher surface is needed for producing a more pronounced impact on the flow, the viability of this method also for pressure-gradient boundary layers is proven.https://cassyni-user-files-prod.s3.amazonaws.com/VmkLnzv8WChAqJM26tvCUW https://cassyni.com/slides/outline/43NWSaDFDNo5NMLxfqRN3P https://cassyni.com/events/43NWSaDFDNo5NMLxfqRN3P/abstract https://cassyni-user-files-prod.s3.amazonaws.com/MDjzvHAniuZNmoaMohRKRg https://cassyni.com/events/43NWSaDFDNo5NMLxfqRN3P?videoPreview=1 Waltzing worms: the dynamics of plant-animal collective vortex structuresnohttps://cassyni.com/events/43NWSaDFDNo5NMLxfqRN3P?videoPreview=12021-05-14T15:00:00+00:001654.84Journal of Fluid MechanicsCircular milling, a stunning manifestation of collective motion, is found across the natural world, from fish shoals to army ants. It has been observed recently that the plant-animal worm Symsagittifera roscoffensis exhibits circular milling behaviour, both in shallow pools at the beach and in Petri dishes in the laboratory. Here in this talk, we investigate this phenomenon, through experiment and theory, from a fluid dynamical viewpoint, focusing on the effect that an established circular mill has on the surrounding fluid. Unlike systems such as confined bacterial suspensions and collections of molecular motors and filaments that exhibit spontaneous circulatory behaviour, and which are modelled as force dipoles, the front-back symmetry of individual worms precludes a stresslet contribution. Instead, singularities such as source dipoles and Stokes quadrupoles are expected to dominate. A series of theoretical models is presented to understand the contributions of these singularities to the azimuthal flow fields generated by a mill, in light of the particular boundary conditions that hold for flow in a Petri dish. A model that treats a circular mill as a rigid rotating disc that generates a Stokes flow is shown to capture basic experimental results well, and gives insights into the emergence and stability of multiple mill systems.https://cassyni-user-files-prod.s3.amazonaws.com/MDjzvHAniuZNmoaMohRKRg https://cassyni.com/slides/outline/EQzCQvoGRzRVtre6gwNFiu https://cassyni.com/events/EQzCQvoGRzRVtre6gwNFiu/abstract https://cassyni-user-files-prod.s3.amazonaws.com/2nhBiXiR4QGRKTqmAKZETg https://cassyni.com/events/EQzCQvoGRzRVtre6gwNFiu?videoPreview=1 Asymptotic Analysis of Waveguides: Topological Protection, Homogenisation, Tunability and Quasiperiodicitynohttps://cassyni.com/events/EQzCQvoGRzRVtre6gwNFiu?videoPreview=12022-07-04T09:50:00+00:001163.04ETOPIMWe present a general approach for studying localised eigenmodes that are created in crystalline media when edges, interfaces and defects are introduced. We will use asymptotic methods to characterise the eigenfrequencies of these modes and will establish a homogenisation regime that can be used to estimate the rate at which they decay away from the defect. Examples of topologically protected modes, such as those based on the famous SSH model, will be used to demonstrate the method. We will see that these concise asymptotic results are invaluable for fine tuning designs, removing the need for expensive numerical optimisation. Finally, we will show how these methods can be extended to quasiperiodic media and will explore the potential advantages of this more challenging setting.https://cassyni-user-files-prod.s3.amazonaws.com/2nhBiXiR4QGRKTqmAKZETg https://cassyni.com/slides/outline/EudoTcSnsSyYtdAzHNf3zD https://cassyni.com/events/EudoTcSnsSyYtdAzHNf3zD/abstract https://cassyni-user-files-prod.s3.amazonaws.com/7yW2hi1Rfi5SsqSSWTxmBL https://cassyni.com/events/EudoTcSnsSyYtdAzHNf3zD?videoPreview=1 A landscape method to unveil high-frequency localized modes of the classical wave equation in heterogeneous medianohttps://cassyni.com/events/EudoTcSnsSyYtdAzHNf3zD?videoPreview=12022-07-05T15:00:00+00:001212.04ETOPIMIn this work we investigate Anderson localization in random acoustic structures through the localization landscape theory. We discuss its limitations for acoustic waves and introduce modifications to recover useful information on localized modes.https://cassyni-user-files-prod.s3.amazonaws.com/7yW2hi1Rfi5SsqSSWTxmBL https://cassyni.com/slides/outline/9UW9x6L23QtUVkvkgTfFzm https://cassyni.com/events/9UW9x6L23QtUVkvkgTfFzm/abstract https://cassyni-user-files-prod.s3.amazonaws.com/RzaWVSJUELq8E2sCsKp3bk https://cassyni.com/slides/outline/MpjtDp22RDf4XurxwPARmX https://cassyni.com/events/MpjtDp22RDf4XurxwPARmX/abstract https://cassyni-user-files-prod.s3.amazonaws.com/UYVWozb6gtHy1FSYJa3Jut https://cassyni.com/events/MpjtDp22RDf4XurxwPARmX?videoPreview=1 Spatially shaping waves to travel deep inside highly reflecting silicon photonic crystalsnohttps://cassyni.com/events/MpjtDp22RDf4XurxwPARmX?videoPreview=12022-07-08T15:20:00+00:00607.04ETOPIMLight is forbidden to travel in periodic nanostructures, such as photonic crystals, when the frequency is within the crystal’s band gap. Using optical wavefront shaping technique, we show the first experimental observations of light transport deep into crystals within the forbidden band and near the band edges of photonic band gap crystals made from silicon.https://cassyni-user-files-prod.s3.amazonaws.com/UYVWozb6gtHy1FSYJa3Jut https://cassyni.com/slides/outline/QHyuTEFecWRYtrLXV554VT https://cassyni.com/events/QHyuTEFecWRYtrLXV554VT/abstract https://cassyni-user-files-prod.s3.amazonaws.com/GWY6irphLFSpDkFLwCSDg2 https://cassyni.com/events/QHyuTEFecWRYtrLXV554VT?videoPreview=1 Carbon Capture Science and Technology Workshop: integrated CO2 capture and utilisationnohttps://cassyni.com/events/QHyuTEFecWRYtrLXV554VT?videoPreview=12022-12-19T12:00:00+00:0010665.44ElsevierCarbon capture and utilisation (CCU) holds great potential to support carbon-intensive industries in their transition to Net Zero. State-of-the-art CCU focuses mainly on the independent development of CO2 capture and utilisation technologies. Note that significant energy is also required for CO2 storage and transportation. Hence, novel technologies are required to intensify CCU via the integrated CCU, i.e., ICCU, to reduce energy consumption. For example, it is reported that CaO-based materials can be used as the sorbent for CO2 capture from flue gas and the catalyst as well for hydrogenation of the captured CO2. The ICCU process showed excellent performance with high CO2 conversions of >75%, which is hardly attainable by conventional CO2 methanation processes. Especially in the ICCU process, the high instant molar ratio of H2 to CO2 provides more thermodynamically favourable conditions to promote CO2 methanation. In this workshop, key findings from well-known researchers in ICCU will be presented. In addition, research challenges related to ICCU or the terms used in the related research technologies will be discussed.https://cassyni-user-files-prod.s3.amazonaws.com/GWY6irphLFSpDkFLwCSDg2 https://cassyni.com/events/MovpuZ5KjknzFwaQv3gHsK/abstract https://cassyni-user-files-prod.s3.amazonaws.com/X3uABRd22gSLKX4WP4CA5C https://cassyni.com/slides/outline/FPVyJffW2obJS7sx49HtGD https://cassyni.com/events/FPVyJffW2obJS7sx49HtGD/abstract https://cassyni-user-files-prod.s3.amazonaws.com/SQpdgUtAn7RsMewnFMQs4J https://cassyni.com/events/FPVyJffW2obJS7sx49HtGD?videoPreview=1 New Insights Into Arterivirus Receptor Usage and Tropismnohttps://cassyni.com/events/FPVyJffW2obJS7sx49HtGD?videoPreview=12025-11-18T10:00:00+00:003940.12Journal of VirologyViruses in the Arteriviridae family are +ssRNA-enveloped viruses within the broader Nidovirales order, which also contains coronaviruses. Although arteriviruses are widespread in mammals (including non-human primates) and can cause a range of serious diseases (including pneumonia, abortion, encephalitis, viral hemorrhagic fever, and subclinical persistent viremia), they have never been shown to infect humans. To shed light on these important but understudied pathogens, join us for the next Journal of Virology Seminar Series webinar, where Adam Bailey, MD, PhD, presents his lab’s recent studies on arteriviruses. The webinar highlights the Bailey Laboratory’s recent paper, Ineffectual immunity in a resurrected mouse model of persistent viremia, which examines arterivirus entry, persistence, tropism, pathogenesis, and cross-species transmission. This body of work underscores the vast unknowns in arterivirus biology and highlights several unexplained phenomena ripe for further investigation. Don’t miss this chance to hear what these findings reveal—and the new questions they raise—about a virus family still full of surprises. Learning Objectives: • Understand what arteriviruses are. • Understand the connections between viral receptor utilization and tropism. • Understand how to develop tools for genetic interrogation of virus/host interactions.https://cassyni-user-files-prod.s3.amazonaws.com/SQpdgUtAn7RsMewnFMQs4J https://cassyni.com/slides/outline/Xhhy9UxXCNjPPRrzSwvnuT https://cassyni.com/events/Xhhy9UxXCNjPPRrzSwvnuT/abstract https://cassyni-user-files-prod.s3.amazonaws.com/BjdpmyZJ3DfvmAqQBESrJi https://cassyni.com/events/Xhhy9UxXCNjPPRrzSwvnuT?videoPreview=1 Astrochemistry and the Making of Planetary Systemsnohttps://cassyni.com/events/Xhhy9UxXCNjPPRrzSwvnuT?videoPreview=12022-12-19T16:00:00+00:002188.84Physics ReportsPlanets form in disks of gas and dust around young stars. The chemistry of these planet-forming disks regulates the compositions of nascent planets, including the planet bulk elemental inventories, and a planet's access to water and reactive organics. In this talk I will introduce the chemical reactions that shape the molecular reservoirs at all stages of star and planet formation, and then review how the different ingredients of the chemistry of planet formation assembles over time as molecular clouds collapses to form protostars and further pre-main sequence stars surrounded by planet forming disks. I will present some of the recent observational, laboratory and theoretical discoveries that have led to the present view of the chemical environment within which planets form, and also discuss some of the remaining open questions about the chemistry of planet formation.https://cassyni-user-files-prod.s3.amazonaws.com/BjdpmyZJ3DfvmAqQBESrJi https://cassyni.com/events/SGaKdxqkNLeJzZckr2vzv1/abstract https://cassyni-user-files-prod.s3.amazonaws.com/HGZAYozbDF8bPuDTjPy74z https://cassyni.com/slides/outline/SmDvgeVGooCMzL9eSUDoBK https://cassyni.com/events/SmDvgeVGooCMzL9eSUDoBK/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Swrq3a1UJ1n9P2C98N2QcW https://cassyni.com/events/SmDvgeVGooCMzL9eSUDoBK?videoPreview=1 Optimal Thinning of MCMC Outputnohttps://cassyni.com/events/SmDvgeVGooCMzL9eSUDoBK?videoPreview=12022-02-03T16:00:00+00:002493.04DataSıgThe use of heuristics to assess the convergence and compress the output of Markov chain Monte Carlo can be sub-optimal in terms of the empirical approximations that are produced. Here we consider the problem of retrospectively selecting a subset of states, of fixed cardinality, from the sample path such that the approximation provided by their empirical distribution is close to optimal. A novel method is proposed, based on greedy minimisation of a kernel Stein discrepancy, that is suitable for problems where heavy compression is required. Theoretical results guarantee consistency of the method and its effectiveness is demonstrated in the challenging context of parameter inference for ordinary differential equations. Software is available in the Stein Thinning package in Python, R and MATLAB.https://cassyni-user-files-prod.s3.amazonaws.com/Swrq3a1UJ1n9P2C98N2QcW https://cassyni.com/events/4Y3jbtNf4CGuBpLUTwYLDb/abstract https://cassyni-user-files-prod.s3.amazonaws.com/AjJaTKCTFxHtgNFjoSz1bt https://cassyni.com/events/4Y3jbtNf4CGuBpLUTwYLDb?videoPreview=1 Machine Learning Meets Control Theorynohttps://cassyni.com/events/4Y3jbtNf4CGuBpLUTwYLDb?videoPreview=12021-02-12T12:00:00+00:001562.24Brunton LabIn this video, we provide a high level overview of reinforcement learning, along with leading algorithms and impressive applications.https://cassyni-user-files-prod.s3.amazonaws.com/AjJaTKCTFxHtgNFjoSz1bt https://cassyni.com/events/FQK2cvcCiGTNi6AW5Un2AR/seminar/qa https://cassyni.com/slides/outline/FQK2cvcCiGTNi6AW5Un2AR https://cassyni.com/events/FQK2cvcCiGTNi6AW5Un2AR/abstract https://cassyni-user-files-prod.s3.amazonaws.com/WjUgV7MYpuvdHVfUS3AnZc https://cassyni.com/events/FQK2cvcCiGTNi6AW5Un2AR?videoPreview=1 Patient Physiotherapy - How to get Patients Moving on Dialysis?, Assisted PD Service, Specialist Role of a PD Nurse in Community Setting & Case Presentationnohttps://cassyni.com/events/FQK2cvcCiGTNi6AW5Un2AR?videoPreview=12023-03-09T11:30:00+00:006186.24Dialysis GroupIn this talk, Dr Hannah Young will outline current evidence around physical activity, exercise and reducing sedentary behaviour for people who are receiving dialysis. She will discuss some simple and brief strategies that can be used in the clinic to nudge people towards becoming more active, and highlight ways to overcome common barriers to activity that this population describe. She will also cover special considerations for particular groups of people, including those living with frailty, and multiple long term conditions. The importance of health inequalities in relation to physical activity will also be explored. Finally, she will cover practical resources and services that are available to support dialysis patients to be more active. Home visiting program creates an opportunity to develop a holistic care delivery for people on peritoneal dialysis (PD) Community nurse's role in coordinating the care and involving other care partners in delivering quality of care in the community- PD is only one component of over all care. The talk will focus on a patient's story Mr JR. we will explore the different issues and how the roles of a community PD nurse could be beneficial based on his case in improving the quality of life of person on dialysis https://cassyni-user-files-prod.s3.amazonaws.com/WjUgV7MYpuvdHVfUS3AnZc https://cassyni.com/slides/outline/Cw51PWNaWygtM9gwXnsPSV https://cassyni.com/events/Cw51PWNaWygtM9gwXnsPSV/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Mm3z4PiTghxo67FuNWNmvv https://cassyni.com/events/Cw51PWNaWygtM9gwXnsPSV?videoPreview=1 Classifier-based Distribution-Dissimilarities: From Maximum Mean Discrepancies to Adversarial Examplesnohttps://cassyni.com/events/Cw51PWNaWygtM9gwXnsPSV?videoPreview=12020-10-22T14:00:00+00:003196.16DataSıgAny binary classifier (or score-function) can be used to define a dissimilarity between two distributions of points with positive and negative labels. Actually, many well-known distribution-dissimilarities are classifier-based dissimilarities: the total variation, the KL- or JS-divergence, the Hellinger distance, etc. And many recent popular generative modelling algorithms compute or approximate these distribution-dissimilarities by explicitly training a classifier: eg GANs and their variants. After a brief introduction to these classifier-based dissimilarities, I will focus on the influence of the classifier's capacity. I will start with some theoretical considerations illustrated on maximum mean discrepancies --a weak form of total variation that has grown popular in machine learning-- and then focus on deep feed-forward networks and their vulnerability to adversarial examples. We will see that this vulnerability is already rooted in the design and capacity of our current networks, and will discuss ideas to tackle this vulnerability in future.https://cassyni-user-files-prod.s3.amazonaws.com/Mm3z4PiTghxo67FuNWNmvv https://cassyni.com/events/BwmoJ95Xe4ajgPrwRpQ4db/seminar/qa https://cassyni.com/slides/outline/BwmoJ95Xe4ajgPrwRpQ4db https://cassyni.com/events/BwmoJ95Xe4ajgPrwRpQ4db/abstract https://cassyni-user-files-prod.s3.amazonaws.com/HxwqVztEwaYCpZUKKAzcNz https://cassyni.com/events/BwmoJ95Xe4ajgPrwRpQ4db?videoPreview=1 Shocks and caps in drop electrohydrodynamicsnohttps://cassyni.com/events/BwmoJ95Xe4ajgPrwRpQ4db?videoPreview=12023-03-29T13:00:00+00:003352.32Journal of Engineering MathematicsThe problem of electrohydrodynamic drop deformation is well understood in the case where the external electric field is weak. In one of his many celebrated papers (Proc. R. Soc. A, 291 1425 159-166, 1966), G. I. Taylor worked out a complete theory in this limit, including analytical expressions for the electrohydrodynamic flow engendered within and outside of the drop by the electric field acting on its own induced interfacial charge, and a simple function of the permittivity, conductivity and viscosity drop-to-background ratios discriminating between prolate-spheroidal or oblate-spheroidal deformation. In this talk, we will employ numerical and asymptotic tools to explore the effects of interfacial-charge convection, which were neglected by Taylor but become important at strong electric fields. In particular, we will analyse (in 2D, for simplicity) how Taylor’s fore-aft symmetric solution evolves as the electrical Reynolds number is increased from zero to arbitrarily large values. What we shall find is hinted by the title of the talk. We will discuss connections between our results, numerical evidence in the literature for the formation of equatorial interfacial-charge “shocks” (a term which we shall challenge), and strong-field experiments exhibiting equatorial streaming, pattern formation and transition to spontaneous drop rotation. This is joint work with Gunnar G. Peng, Rodolfo Brandão and Ehud Yariv. https://cassyni-user-files-prod.s3.amazonaws.com/HxwqVztEwaYCpZUKKAzcNz https://cassyni.com/slides/outline/NpCpzxQPiJKa5qTDibsjbK https://cassyni.com/events/NpCpzxQPiJKa5qTDibsjbK/abstract https://cassyni-user-files-prod.s3.amazonaws.com/N6i622bssR5icTa6Tc6iSz https://cassyni.com/events/NpCpzxQPiJKa5qTDibsjbK?videoPreview=1 Rising Stars in Organic Synthesis, Session 1nohttps://cassyni.com/events/NpCpzxQPiJKa5qTDibsjbK?videoPreview=12023-01-26T22:00:00+00:006423.24Thieme GroupIn 2022, Science of Synthesis established the first Early Career Advisory Board (ECAB) to learn about their ideas and perspectives on organic synthesis and research in general. They have given us valuable support throughout the first year of their term and we want to thank them by hosting some of them as speakers.https://cassyni-user-files-prod.s3.amazonaws.com/N6i622bssR5icTa6Tc6iSz https://cassyni.com/events/Dw3ADz2u4Z2Zsom2Kbemxq/seminar/qa https://cassyni.com/slides/outline/Dw3ADz2u4Z2Zsom2Kbemxq https://cassyni.com/events/Dw3ADz2u4Z2Zsom2Kbemxq/abstract https://cassyni-user-files-prod.s3.amazonaws.com/7BF8dRTDdRnoZ1yFy3RngN https://cassyni.com/events/Dw3ADz2u4Z2Zsom2Kbemxq?videoPreview=1 A new therapeutic target in traumatic brain injury (TBI)? Serum amyloid P component accumulates and persists in neurones following TBInohttps://cassyni.com/events/Dw3ADz2u4Z2Zsom2Kbemxq?videoPreview=12024-10-29T14:00:00+00:003349.52Royal Society PublishingThe mechanisms underlying neurodegenerative sequelae of traumatic brain injury (TBI) are poorly understood. The normal plasma protein, serum amyloid P component (SAP), which is normally rigorously excluded from the brain, is directly neurocytotoxic for cerebral neurones and also binds to Aβ amyloid fibrils and neurofibrillary tangles, promoting formation and persistence of Aβ fibrils. Increased brain exposure to SAP is common to many risk factors for dementia, including TBI, and dementia at death in the elderly is significantly associated with neocortical SAP content. Here, in 18 of 30 severe TBI cases, we report immunohistochemical staining for SAP in contused brain tissue with blood–brain barrier disruption. The SAP was localized to neurofilaments in a subset of neurones and their processes, particularly damaged axons and cell bodies, and was present regardless of the time after injury. No SAP was detected on astrocytes, microglia, cerebral capillaries or serotoninergic neurones and was absent from undamaged brain. C-reactive protein, the control plasma protein most closely similar to SAP, was only detected within capillary lumina. The appearance of neurocytotoxic SAP in the brain after TBI, and its persistent, selective deposition in cerebral neurones, are consistent with a potential contribution to subsequent neurodegeneration.https://cassyni-user-files-prod.s3.amazonaws.com/7BF8dRTDdRnoZ1yFy3RngN https://cassyni.com/events/VFAWmoc457821D3F8MbUgm/seminar/qa https://cassyni.com/slides/outline/VFAWmoc457821D3F8MbUgm https://cassyni.com/events/VFAWmoc457821D3F8MbUgm/abstract https://cassyni-user-files-prod.s3.amazonaws.com/NUECThHbgCja7omUEtGFw4 https://cassyni.com/events/VFAWmoc457821D3F8MbUgm?videoPreview=1 Do large language models have a legal duty to tell the truth?nohttps://cassyni.com/events/VFAWmoc457821D3F8MbUgm?videoPreview=12024-10-16T13:00:00+00:003924.32Royal Society PublishingCareless speech is a new type of harm created by large language models (LLM) that poses cumulative, long-term risks to science, education and shared social truth in democratic societies. LLMs produce responses that are plausible, helpful and confident, but that contain factual inaccuracies, misleading references and biased information. These subtle mistruths are poised to cumulatively degrade and homogenize knowledge over time. This article examines the existence and feasibility of a legal duty for LLM providers to create models that ‘tell the truth’. We argue that LLM providers should be required to mitigate careless speech and better align their models with truth through open, democratic processes. We define careless speech against ‘ground truth’ in LLMs and related risks including hallucinations, misinformation and disinformation. We assess the existence of truth-related obligations in EU human rights law and the Artificial Intelligence Act, Digital Services Act, Product Liability Directive and Artificial Intelligence Liability Directive. Current frameworks contain limited, sector-specific truth duties. Drawing on duties in science and academia, education, archives and libraries, and a German case in which Google was held liable for defamation caused by autocomplete, we propose a pathway to create a legal truth duty for providers of narrow- and general-purpose LLMs.https://cassyni-user-files-prod.s3.amazonaws.com/NUECThHbgCja7omUEtGFw4 https://cassyni.com/events/BxVzGWUa7SfdUoyNraoZ3j/abstract https://cassyni-user-files-prod.s3.amazonaws.com/7cw3Cs5QPPxCYBFhk9EgMt https://cassyni.com/events/NpnuQBE1Asmq9s5eiXb1rM/seminar/qa https://cassyni.com/slides/outline/NpnuQBE1Asmq9s5eiXb1rM https://cassyni.com/events/NpnuQBE1Asmq9s5eiXb1rM/abstract https://cassyni-user-files-prod.s3.amazonaws.com/VnjLC3J5dXV4YCGr3mW7eW https://cassyni.com/events/NpnuQBE1Asmq9s5eiXb1rM?videoPreview=1 Inclusive Science: Redefining Impact for Researchnohttps://cassyni.com/events/NpnuQBE1Asmq9s5eiXb1rM?videoPreview=12024-11-13T09:00:00+00:003893.84Topics at the heart of our communityDid you know that up to 50% of funded research ultimately goes unpublished, and in so doing wastes billions of dollars? This includes many studies from non-Western countries, where predominantly Western editors may perceive research as lower quality or less significant. Ritu Dhand, Springer Nature’s Chief Scientific Officer, will explain how inclusive science is about understanding that research can advance discovery in ways both incremental and fundamental, and challenge the misconception that the former is less impactful or of lesser quality.https://cassyni-user-files-prod.s3.amazonaws.com/VnjLC3J5dXV4YCGr3mW7eW https://cassyni.com/events/HPfFtf7ELqgkkzqR7cbDru/seminar/qa https://cassyni.com/slides/outline/HPfFtf7ELqgkkzqR7cbDru https://cassyni.com/events/HPfFtf7ELqgkkzqR7cbDru/abstract https://cassyni-user-files-prod.s3.amazonaws.com/8Se7pt5mLk3An6e2tgVCRt https://cassyni.com/events/HPfFtf7ELqgkkzqR7cbDru?videoPreview=1 Machine Learning and AI for the Sciences: toward understandingnohttps://cassyni.com/events/HPfFtf7ELqgkkzqR7cbDru?videoPreview=12024-11-21T13:00:00+00:003283.04MOX Laboratory - Department of MathematicsIn recent years, machine learning (ML) and artificial intelligence (AI) methods have begun to play a more and more enabling role in the sciences and in industry. In particular, the advent of large and/or complex data corpora has given rise to new technological challenges and possibilities. In his talk, Müller will touch upon the topic of ML applications in the sciences, in particular in chemistry and physics. He will also discuss possibilities for extracting information from machine learning models to further our understanding by explaining nonlinear ML models. Finally, Müller will briefly discuss perspectives and limitations.https://cassyni-user-files-prod.s3.amazonaws.com/8Se7pt5mLk3An6e2tgVCRt https://cassyni.com/slides/outline/FR3DbJ1FBeYGWWGwWFBWaZ https://cassyni.com/events/FR3DbJ1FBeYGWWGwWFBWaZ/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Y7dpTp91jihH3ZryeP8PeE https://cassyni.com/events/FR3DbJ1FBeYGWWGwWFBWaZ?videoPreview=1 Advanced dynamic simulation of soft robotic metamaterialsnohttps://cassyni.com/events/FR3DbJ1FBeYGWWGwWFBWaZ?videoPreview=12024-10-11T08:00:00+00:002159.04UK Metamaterials NetworkSoft robotic metamaterials, composed primarily of pliable materials, exhibit mechanically robust maneuvers that surpass the capabilities of conventional rigid robotic systems. However, the design and control of these innovative robots are often hindered by current simulation limitations, necessitating laborious trial-and-error processes. This seminar will introduce state-of-the-art numerical tools designed to enhance the dynamic simulation and control of soft robots, thereby streamlining their development and operational efficiency. In particular, the seminar will focus on addressing three critical challenges inherent to soft robotic systems: managing nonlinear dynamics, facilitating interaction with complex environments, and ensuring real-time responsiveness. Through the integration of advanced simulation techniques, we aim to overcome these obstacles and unlock the full potential of soft robotics. To illustrate the practical applications and benefits of these numerical tools, we will showcase several robotic simulators. These examples include shape-memory-alloy powered soft robots, flagella-inspired robots, magnetic cilia robots, snap-jump robots, and space-tethered net robots. Each simulator will demonstrate the tools' efficiency and effectiveness in real-world scenarios, highlighting their capabilities in both evolutionary design and online control of intelligent robotic systems. The computationally efficient and robust numerical tools presented in this seminar not only serve as benchmarks for the evolutionary design of soft robots but also pave the way for their real-time control in dynamic environments. Attendees will gain insights into the latest advancements in soft robotics simulation and control, equipping them with the knowledge to push the boundaries of what is possible with these cutting-edge technologies.https://cassyni-user-files-prod.s3.amazonaws.com/Y7dpTp91jihH3ZryeP8PeE https://cassyni.com/slides/outline/NL9JMVaUjRDnA6Ym86JDb3 https://cassyni.com/events/NL9JMVaUjRDnA6Ym86JDb3/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Ph9EKgfyi1jR1Nav6LPzhC https://cassyni.com/events/NL9JMVaUjRDnA6Ym86JDb3?videoPreview=1 Panel Discussion—Moving Toward Equity: Identifying and Mitigating Disparities in Cancer Care from Screening to Survivalnohttps://cassyni.com/events/NL9JMVaUjRDnA6Ym86JDb3?videoPreview=12025-01-13T17:00:00+00:003535.2Sage PublishingConsiderable advancements in cancer screening, diagnosis, treatment, and survivorship care have led to improved outcomes for millions of people with cancer. Unfortunately, equity in the benefits of these improvements has not been realized. Decades worth of research is clear that timeliness of screening and diagnosis, quality of treatment, and, by extension, quality of life and mortality are associated with population demographics resulting in persistent disparities. Historically, we have examined cancer disparities by patient race and ethnicity, but growing bodies of research are also demonstrating disparate care and outcome patterns based on other patient factors, including age, sexual orientation and gender identity, body weight, and the neighborhood and built environment where an individual lives, among others. This panel discussion focuses on advancing knowledge of disparities and efforts to mitigate those disparities as it relates to cancer care and outcomes. Co-Chairs Dr. Lauren Hamel and Dr. Yvonne Eaglehouse are Guest Editors of a Special Collection in Cancer Control on the theme of "Moving Toward Equity: Identifying and Mitigating Disparities in Cancer Care from Screening to Survival." Authors are especially encouraged to submit works focused on emerging areas of cancer disparities research, research that includes community engagement, and research that develops and tests interventions to mitigate disparities.https://cassyni-user-files-prod.s3.amazonaws.com/Ph9EKgfyi1jR1Nav6LPzhC https://cassyni.com/slides/outline/VjsN3kHMKHXceg5E5y9x13 https://cassyni.com/events/VjsN3kHMKHXceg5E5y9x13/abstract https://cassyni-user-files-prod.s3.amazonaws.com/ULaSQqG5CTZbgNpUHWXHGz https://cassyni.com/events/VjsN3kHMKHXceg5E5y9x13?videoPreview=1 Neuroscience Approaches to Stroke Rehabilitation and Predictions of Brain Healthnohttps://cassyni.com/events/VjsN3kHMKHXceg5E5y9x13?videoPreview=12024-11-12T03:00:00+00:004028.04The Auckland Bioengineering InstituteUp to 80% of people who experience a right-hemisphere stroke suffer from hemispatial neglect, a severe visuospatial impairment, where they fail to perceive/misperceive items presented in the contralesional part of space. This syndrome is debilitating, impedes rehabilitation, and is a strong independent predictor of poor recovery. In my talk I will present data showing that immediate on-line actions are relatively unimpaired in these neglect patients. Building on this insight, I will discuss two recent rehabilitation studies where we assessed whether these spared actions could be exploited for neglect rehabilitation a) via behavioural visuomotor feedback training or b) in a clinical trial using non-invasive brain stimulation. I will also discuss the feasibility of using virtual and augmented reality for cognitive training and stroke rehabilitation. I will finish by presenting a first AI foundation model we have started to build to estimate cognitive impairments from brain (MR) images. Cognitive performances are often evaluated using medical assessments, while brain imaging would offer a more reliable and reproducible estimate of cognitive function, and its decline over time. With recent advances in artificial intelligence, as well as the increasing availability of open datasets like the UK Biobank, I will introduce a novel way to interpret brain images, training an AI model from a multitude of cognition data. https://cassyni-user-files-prod.s3.amazonaws.com/ULaSQqG5CTZbgNpUHWXHGz https://cassyni.com/slides/outline/TGdLpL3j7zm5cWqSdBMazq https://cassyni.com/events/TGdLpL3j7zm5cWqSdBMazq/abstract https://cassyni-user-files-prod.s3.amazonaws.com/QNsFScMMVViPyMPD2qPUHc https://cassyni.com/events/TGdLpL3j7zm5cWqSdBMazq?videoPreview=1 Maximizing the impact of your expertise: using health system data to improve treatment retention for opioid use disordernohttps://cassyni.com/events/TGdLpL3j7zm5cWqSdBMazq?videoPreview=12025-06-26T20:00:00+00:003483.04Family MedicineObjectives: * Understand the concept of the OUD care cascade and its utility for studying treatment outcomes * Describe inequities in treatment utilization for patients with OUD * Demonstrate the power of health system and administrative data to indicate when and where local OUD treatment inequities emergehttps://cassyni-user-files-prod.s3.amazonaws.com/QNsFScMMVViPyMPD2qPUHc https://cassyni.com/events/DSURXBw2qBFbyLNjiW1BG1/abstract https://cassyni-user-files-prod.s3.amazonaws.com/GW5beMK9yBUs7GaoMwkS3G https://cassyni.com/slides/outline/PKU8ZVPR1hFeyL5AWdhz2Z https://cassyni.com/events/PKU8ZVPR1hFeyL5AWdhz2Z/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Ac7qd3CspZYCDbfauj1iRC https://cassyni.com/events/PKU8ZVPR1hFeyL5AWdhz2Z?videoPreview=1 Reimagining healthcare: novel collaborative pathwaysnohttps://cassyni.com/events/PKU8ZVPR1hFeyL5AWdhz2Z?videoPreview=12024-09-26T14:00:00+00:005440.6Frontiers in ScienceIn this Frontiers Forum Deep Dive session on 26 September 2024, Prof Michel Goldman explored how interdisciplinary innovations in drug development, personalized care, modeling, and more are driving the future of medicine. He was joined for a panel discussion and audience question and answer session by Prof Thomas Hartung, Dr Pamela Tenaerts, Dr Olusoji Adeyi and Dr Melanie Saville. The session brought together the authors of the Frontiers in Science lead article ‘Standing the test of COVID-19: charting the new frontiers of medicine’ to discuss how COVID-19 accelerated biomedical innovation, and how new types of collaborations spanning multiple sectors—from science and healthcare to regulation, policy, and economics—will make this vision a reality for all. https://cassyni-user-files-prod.s3.amazonaws.com/Ac7qd3CspZYCDbfauj1iRC https://cassyni.com/events/16HwUjGoG6LWuMbYwpGd2m/abstract https://cassyni-user-files-prod.s3.amazonaws.com/5J9WxpMLMCdeTj5pnrBKGr https://cassyni.com/events/AyG2QQDJ3FQqksbaTP2zAh/seminar/qa https://cassyni.com/slides/outline/AyG2QQDJ3FQqksbaTP2zAh https://cassyni.com/events/AyG2QQDJ3FQqksbaTP2zAh/abstract https://cassyni-user-files-prod.s3.amazonaws.com/KrE7ABb4Ki9T2CHegzNvWa https://cassyni.com/events/AyG2QQDJ3FQqksbaTP2zAh?videoPreview=1 Bubble dynamics in complex fluidsnohttps://cassyni.com/events/AyG2QQDJ3FQqksbaTP2zAh?videoPreview=12025-02-07T16:00:00+00:004099.04Journal of Fluid MechanicsBubble dynamics and cavitation have traditionally been studied in the context of underwater acoustics and, more recently, biomedical applications. I will discuss how the deformation and flow fields generated by acoustically-driven bubbles can be used to drive self-assembly of novel microstructures in complex fluids. Bubble dynamics driven at ultrasonic frequencies probe time scales as short as $10^{–3} - 10^{–6}$ s, comparable to the smallest relaxation time scales for complex fluids containing suspended particles or macromolecules. I will describe how, in this dynamical regime, dynamic capillary interactions arise between colloidal particles adsorbed at a fluid interface, producing particle networks that dominate the mechanics of these complex interfaces under flow. I will also describe a new flow-induced mechanism caused by bubble dynamics, that produces ordered microstructures in colloidal gels. This mechanism can enable energy-efficient processing methods of colloidal-gel materials, including inks, battery electrodes, construction materials. I will also discuss the emerging approach of using bubble dynamics to probe the high-frequency viscoelastic properties of complex fluids and soft materials, which has brought together the communities of cavitation and rheology to address new challenges in characterization of soft materials. https://cassyni-user-files-prod.s3.amazonaws.com/KrE7ABb4Ki9T2CHegzNvWa https://cassyni.com/slides/outline/AUcRMiZmbnrnm74grwkBuP https://cassyni.com/events/AUcRMiZmbnrnm74grwkBuP/abstract https://cassyni-user-files-prod.s3.amazonaws.com/GMiLgusi994kr7ZgRBHC1t https://cassyni.com/events/AUcRMiZmbnrnm74grwkBuP?videoPreview=1 Enhance Your Writing And Peer Review In Biomedical Research With Reporting Guidelinesnohttps://cassyni.com/events/AUcRMiZmbnrnm74grwkBuP?videoPreview=12022-04-07T03:00:00+00:004774.48UKRNReporting guidelines aim to help authors in preparing journal articles by listing the minimum information needed about a particular study design in order for the results to be replicated or used. Many journals, particularly in biomedical research, require reporting guideline use and the submission of a completed checklist alongside a manuscript.https://cassyni-user-files-prod.s3.amazonaws.com/GMiLgusi994kr7ZgRBHC1t https://cassyni.com/slides/outline/ayAe3SD6upLipb4jvPbCy https://cassyni.com/events/ayAe3SD6upLipb4jvPbCy/abstract https://cassyni-user-files-prod.s3.amazonaws.com/AATkBuihrBBEA8FdF6zfQS https://cassyni.com/events/DwBGo8cL5MfCcVpsiGxKM7/abstract https://cassyni-user-files-prod.s3.amazonaws.com/EAhSHMctyDahfG5y1Xpppe https://cassyni.com/events/BTwFZiNht4tfaLb6FV9xLu/seminar/qa https://cassyni.com/slides/outline/BTwFZiNht4tfaLb6FV9xLu https://cassyni.com/events/BTwFZiNht4tfaLb6FV9xLu/abstract https://cassyni-user-files-prod.s3.amazonaws.com/4cXiVXjvPn387kKVRiGeea https://cassyni.com/events/BTwFZiNht4tfaLb6FV9xLu?videoPreview=1 Heuristic Design of Mechanical Metamaterials with High Load-bearing and High Energy-absorption Integrationnohttps://cassyni.com/events/BTwFZiNht4tfaLb6FV9xLu?videoPreview=12025-03-25T09:00:00+00:003774.72MetaMATRecent tendencies of lightweight and multifunction integration in aerospace, automobile, and national defence have raised urgent demands for materials that simultaneously possess high load-bearing ability and high energy-absorption capacity. In this seminar, I will present our recent work on the design of advanced lightweight lattice materials through inspiration from bio-skeletons, microstructure of cystals, and four-dimensional hypercubes. As a typical example, a bio-inspired multi-feature lattice material is proposed that integrates the features of the double-diagonal reinforcement in deep-sea glass sponges and the curled fibres in luffa pulp. The proposed lattice simultaneously possesses high strength, high energy absorption, considerable toughness, as well as controllable deformation patterns. The second example is the micro-inspired lattices that are developed by introducing the polycrystalline-like interfaces or the heterogeneous second-phase cells into the conventional lattice materials. The proposed lattice materials exhibit significant enhancement of the mechanical properties due to the hindering effect of the introduced heterogeneities on the shear band formation and propagation. The third example is the hypercube lattice that is inspired from the four-dimensional hypercube (or Tesseract in science-fiction film). The proposed structure can realize simultaneous isotropic stiffness and isotropic strength, and has promising potential for mechanical-acoustic integrated performance. This work is aimed at providing pathways for the design of new lattice materials with outstanding performances in multiple application scenarios including load-bearing, blast protection and accoustic attenuation.https://cassyni-user-files-prod.s3.amazonaws.com/4cXiVXjvPn387kKVRiGeea https://cassyni.com/events/PpAyqS4iFsfFcVXJWQf87f/seminar/qa https://cassyni.com/slides/outline/PpAyqS4iFsfFcVXJWQf87f https://cassyni.com/events/PpAyqS4iFsfFcVXJWQf87f/abstract https://cassyni-user-files-prod.s3.amazonaws.com/4NZC2jdw4aquEUbzr3yNJJ https://cassyni.com/events/PpAyqS4iFsfFcVXJWQf87f?videoPreview=1 Application of Gauss' Principle to the Classical Airfoil Problemnohttps://cassyni.com/events/PpAyqS4iFsfFcVXJWQf87f?videoPreview=12025-11-06T17:00:00+00:003556.48AIAA JournalGauss’s principle of least constraint is applied to the classical problem of lift of a two-dimensional airfoil in ideal, incompressible flow and examines the role of the empirical Kutta condition in classical airfoil theory. Gauss’s principle demonstrates that the fluid pressure field of a lifting airfoil comprises both a constraint pressure and an impressed pressure of arbitrary strength. Gauss’s principle also proves that a flow solution that minimizes the difference between the acceleration and the impressed pressure gradient is a valid solution of Euler’s equation. Furthermore, Gauss’s principle proves that a first-principles closure condition cannot exist thus reaffirming the need for the empirical Kutta condition to complete classical airfoil theory. This investigation also disproves a new variational theory of lift derived from Hertz’s principle of minimum curvature that claims to replace the empirical Kutta condition with a first-principles based closure condition. This new theory predicts airfoil lift for conventional airfoils consistent with classical theory, however, for other airfoils, the predictions are highly implausible; e.g., zero lift for the flat plate, and negative lift for an airfoil in reverse flow. The present investigation explains why the new theory is invalid.https://cassyni-user-files-prod.s3.amazonaws.com/4NZC2jdw4aquEUbzr3yNJJ https://cassyni.com/slides/outline/TmLC6Gj2NBAgFgHacxJj5w https://cassyni.com/events/TmLC6Gj2NBAgFgHacxJj5w/abstract https://cassyni-user-files-prod.s3.amazonaws.com/918iyKcB2n3PFb6i5ZNE6a https://cassyni.com/events/TmLC6Gj2NBAgFgHacxJj5w?videoPreview=1 Impact of zinc on arbuscular mycorrhizal-mediated nutrient acquisition in urban horticulturenohttps://cassyni.com/events/TmLC6Gj2NBAgFgHacxJj5w?videoPreview=12024-08-13T12:00:00+00:00882.56The New Phytologist FoundationA major barrier to improving global food security is the availability of suitable land for horticulture. Urban areas offer potential, but their soils often accumulate pollutants like zinc due to unregulated use of manures and pesticides. The impact of zinc on soil health and soil-borne plant symbiotic microbes, such as arbuscular mycorrhizal fungi (AMF), is not well understood. Our study investigated the effect of environmentally relevant zinc concentrations on AMF's role in plant nutrient uptake. We found that while all plants were successfully colonised by the fungus, higher zinc levels significantly reduced phosphorus transfer from fungi to plants and carbon movement from plants to fungi. These findings suggest that although urban horticulture could enhance local food production and address food security, the impacts of soil contaminants such as zinc need to be considered to maximise the potential of urban soils.https://cassyni-user-files-prod.s3.amazonaws.com/918iyKcB2n3PFb6i5ZNE6a https://cassyni.com/events/JsgwNbbTsJ8EDPoxVvx8PX/abstract https://cassyni-user-files-prod.s3.amazonaws.com/32jJzfDDNs5RjFxhjYKftz https://cassyni.com/slides/outline/726p9ZYyvwuR7gqJLqPPCR https://cassyni.com/events/726p9ZYyvwuR7gqJLqPPCR/abstract https://cassyni-user-files-prod.s3.amazonaws.com/WwqZtbdTFjaTYG3rq61ger https://cassyni.com/events/726p9ZYyvwuR7gqJLqPPCR?videoPreview=1 High-order Method for High-speed Flow Simulations with Real-gas Effectsnohttps://cassyni.com/events/726p9ZYyvwuR7gqJLqPPCR?videoPreview=12024-12-05T08:00:00+00:002306.36JKW Symposium TeamThis presentation highlights recent advancements in high-order numerical methods for simulating hypersonic flows with real-gas effects. High-speed aerodynamics poses significant computational challenges due to strong shock waves, intense aerodynamic heating, vibrational and electronic energy excitations, and thermo-chemical nonequilibrium. Conventional low-order schemes often fall short in accurately resolving these complex phenomena. To address this, a physical-domain-based discontinuous Galerkin method incorporating the Direct Reconstruction Method (DRM-DG) is introduced, offering high accuracy and efficiency on curved hybrid meshes. In addition, advanced shock-capturing strategies are presented, including a novel PID-controlled artificial viscosity method (SPID) with limiting based error estimation, which enhances robustness and convergence, particularly in steady-state simulations. This talk also introduces comprehensive frameworks for modeling high-temperature gas dynamics in both equilibrium and non-equilibrium regimes. Notably, the open-source neural network-based library, IDEA, enables fast and accurate prediction of air properties up to 25,000 K. These methods are implemented in the open-source high-order solver, Deneb, and validated through a series of challenging hypersonic test cases, demonstrating their applicability in both academic research and industrial applications.https://cassyni-user-files-prod.s3.amazonaws.com/WwqZtbdTFjaTYG3rq61ger https://cassyni.com/events/JP3LKuwwRqaBDdH4uVfL8D/seminar/qa https://cassyni.com/slides/outline/JP3LKuwwRqaBDdH4uVfL8D https://cassyni.com/events/JP3LKuwwRqaBDdH4uVfL8D/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Su4iogVxAnYQ3Coi6HAfC2 https://cassyni.com/slides/outline/UG1RFatSCzeW59H6R4RhG9 https://cassyni.com/events/UG1RFatSCzeW59H6R4RhG9/abstract https://cassyni-user-files-prod.s3.amazonaws.com/5evXVdrCeLodqoFZw26pBg https://cassyni.com/events/UG1RFatSCzeW59H6R4RhG9?videoPreview=1 Keynote: Malika N. Pryor, International African American Museum (Charleston Conference)nohttps://cassyni.com/events/UG1RFatSCzeW59H6R4RhG9?videoPreview=12024-11-12T15:00:00+00:002240.8Part of the nonprofit Annual Reviews organizationAAM: our beginnings and the role museums play in building stronger communities. Since the opening of the International African American Museum, the museum has activated several programs to encourage community participation and engagement. Explore initiatives that connect families to their stories, inspire students to connect to history and visitors to connect to each other. Image credit: [Leo Heisenberg (Unsplash)](https://unsplash.com/photos/yellow-and-blue-concrete-building-ajxP9gEhu30).https://cassyni-user-files-prod.s3.amazonaws.com/5evXVdrCeLodqoFZw26pBg https://cassyni.com/slides/outline/RnmQ2Aep1ht1iCoXsNX4YD https://cassyni.com/events/RnmQ2Aep1ht1iCoXsNX4YD/abstract https://cassyni-user-files-prod.s3.amazonaws.com/HtQ6FTwgXi44CJbBiJe5zn https://cassyni.com/events/RnmQ2Aep1ht1iCoXsNX4YD?videoPreview=1 Numerical simulations reveal complementary function of blood-brain barrier and glymphatic transport in the brainnohttps://cassyni.com/events/RnmQ2Aep1ht1iCoXsNX4YD?videoPreview=12025-04-18T15:00:00+00:001434.04Cassyni SeminarsThe brain accounts for approximately 20% of metabolism and, as a result, generates protein waste which requires efficient clearance. Failure to clear such waste leads to formation of toxic protein aggregates implicated in a variety of neurodegenerative diseases, including Alzheimer’s and Parkinson’s. The blood-brain barrier and the glymphatic system are two parallel transport pathways that remove waste from the brain, but very few studies have investigated their interactions or complementary function. Herein, we develop a Lattice Boltzmann simulation of waste clearance from an idealized segment of brain tissue and test the effects of selectively activating or deactivating each pathway. We model clearance of the peptide amyloid-β, long recognized as critical in Alzheimer’s pathology, and calibrate our model against limited experimental data. This approach uncovers critical parameters that have eluded prior experimental measurement. Our study also reveals complementary functionality of the blood-brain barrier and glymphatic system that are likely generic features applicable to the transport of large molecules (e.g., proteins) in the brain.https://cassyni-user-files-prod.s3.amazonaws.com/HtQ6FTwgXi44CJbBiJe5zn https://cassyni.com/events/EvW718RGMdh5RjMH6pN5nd/seminar/qa https://cassyni.com/slides/outline/EvW718RGMdh5RjMH6pN5nd https://cassyni.com/events/EvW718RGMdh5RjMH6pN5nd/abstract https://cassyni-user-files-prod.s3.amazonaws.com/SE4gA9iGtZnfvBZkRNWE6J https://cassyni.com/events/EvW718RGMdh5RjMH6pN5nd?videoPreview=1 Data Insights to Advance Editorial Board Diversitynohttps://cassyni.com/events/EvW718RGMdh5RjMH6pN5nd?videoPreview=12025-05-16T08:00:00+00:002582.08Topics at the heart of our communitySowmya Swaminathan, Director, DEI, Research will speak about how Springer Nature is taking a data-informed approach to support diversifying editorial boards and gender representation in peer review and its importance in inclusive publishing.https://cassyni-user-files-prod.s3.amazonaws.com/SE4gA9iGtZnfvBZkRNWE6J https://cassyni.com/slides/outline/53Y25TUmaUckaDMFbFbieh https://cassyni.com/events/53Y25TUmaUckaDMFbFbieh/abstract https://cassyni-user-files-prod.s3.amazonaws.com/XMqrY2nVMcqEDnARZhJ1up https://cassyni.com/events/53Y25TUmaUckaDMFbFbieh?videoPreview=1 Interdisciplinary Approaches to Water Managementnohttps://cassyni.com/events/53Y25TUmaUckaDMFbFbieh?videoPreview=12025-03-25T08:30:00+00:001434.04Cambridge PrismsThis webinar aims to discuss the socioeconomics of water systems, focusing on efficiency and equity, integrated into an interdisciplinary framework with a view to implementing sustainabilityhttps://cassyni-user-files-prod.s3.amazonaws.com/XMqrY2nVMcqEDnARZhJ1up https://cassyni.com/events/7Wn3JsiPmmPEw9pp8wWMNd/seminar/qa https://cassyni.com/slides/outline/7Wn3JsiPmmPEw9pp8wWMNd https://cassyni.com/events/7Wn3JsiPmmPEw9pp8wWMNd/abstract https://cassyni-user-files-prod.s3.amazonaws.com/RMijJr4yqBMHhxRjsRcaFQ https://cassyni.com/events/7Wn3JsiPmmPEw9pp8wWMNd?videoPreview=1 Direct Exploration of the L2 Isolated Invariant Set Using Isolating Neighborhoods, Low-thrust trajectory design for icy moons orbiters using multi-body techniquesnohttps://cassyni.com/events/7Wn3JsiPmmPEw9pp8wWMNd?videoPreview=12025-04-24T13:00:00+00:003899.04Celestial Mechanics and Dynamical AstronomyPrevious studies have used isolating blocks to explore the isolated invariant set around the L$_2$ Lagrange point in the circular restricted three-body problem by computing trajectories on the asymptotic set and using them to track particular orbits. Once an initial map of the location of the orbits within the isolated invariant set projected into configuration space has been found, it is possible to further explore these orbits more directly by starting from appropriately chosen points within the mapped space. Here, we develop a method that uses these points to explore the periodic and quasiperiodic orbits within the isolated invariant set. Icy moons of our Solar system are currently one of the focuses of the leading space agencies in the search for extraterrestrial life. Especially, Enceladus is a prime target because of the presence of geyser-like jets of water emanating from its south pole. Future missions to Enceladus would benefit from inter-moon transfers of the Saturnian system to reach Enceladus. However, such trajectories are challenging to design, due to the highly nonlinear, often chaotic, multibody dynamics with close encounters of the planetary moons. The trajectory design is even more complex when low-thrust propulsion is used due to the long-duration, multi-revolution nature of the solutions. The approach outlined in this paper confronts this shortcoming by exploiting multi-body dynamics to construct a ‘resonant hopping’ trajectory, which is then optimized using indirect methods. Unstable resonant orbits are pre-computed and provide a starting point to a multiple indirect shooting method in a forward–backward fashion. The insights from multi-body dynamics steer the algorithm to a near-ballistic solution. The use of indirect optimization allows the design of long-duration, multi-revolution low-thrust trajectory, with a limited number of optimization variables. Finally, forward–backward shooting technique reduces the sensitivities to constraints satisfaction. This strategy is employed to design a low-thrust inter-moon transfer between a close resonant orbit of Tethys and a near rectilinear halo orbit around Enceladus.https://cassyni-user-files-prod.s3.amazonaws.com/RMijJr4yqBMHhxRjsRcaFQ https://cassyni.com/slides/outline/44Eoz6BihZWbuTXFVH8Pqo https://cassyni.com/events/44Eoz6BihZWbuTXFVH8Pqo/abstract https://cassyni-user-files-prod.s3.amazonaws.com/EVgLReb4zq9A9UiP16rfZG https://cassyni.com/events/44Eoz6BihZWbuTXFVH8Pqo?videoPreview=1 Keynote: APE at 20 - Looking Back, Looking Forwardnohttps://cassyni.com/events/44Eoz6BihZWbuTXFVH8Pqo?videoPreview=12025-01-14T12:00:00+00:006470.76Academic Publishing in EuropeOur speakers reflect on two decades of scholarly communication milestones and envision groundbreaking ideas for the next 20 years.https://cassyni-user-files-prod.s3.amazonaws.com/EVgLReb4zq9A9UiP16rfZG https://cassyni.com/events/25E45usKuKQK23JwCmiKxy/seminar/qa https://cassyni.com/slides/outline/25E45usKuKQK23JwCmiKxy https://cassyni.com/events/25E45usKuKQK23JwCmiKxy/abstract https://cassyni-user-files-prod.s3.amazonaws.com/HDTzGhUF8Mgw3oqrjSN77L https://cassyni.com/events/25E45usKuKQK23JwCmiKxy?videoPreview=1 Primary Care Workforce Development in Rhode Islandnohttps://cassyni.com/events/25E45usKuKQK23JwCmiKxy?videoPreview=12025-05-29T20:00:00+00:004076.36Family MedicineObjectives: * Explain the problems with existing methods for estimating primary care workforce and describe the magnitude of the difference in estimates when considering FTEs * Summarize the key components of Governor McKee's plan to strengthen Rhode Island's primary care system and estimate the potential impact of these programs on primary care capacity in RI * Evaluate the potential impact of informatics innovations including AI scribes and continuity support on the primary care workforcehttps://cassyni-user-files-prod.s3.amazonaws.com/HDTzGhUF8Mgw3oqrjSN77L https://cassyni.com/events/FQjNLNLVkgMGuFcXMzredj/seminar/qa https://cassyni.com/slides/outline/FQjNLNLVkgMGuFcXMzredj https://cassyni.com/events/FQjNLNLVkgMGuFcXMzredj/abstract https://cassyni-user-files-prod.s3.amazonaws.com/FbqBJTVhxJeBEnaBjUWMBL https://cassyni.com/events/FQjNLNLVkgMGuFcXMzredj?videoPreview=1 How to write a successful research papernohttps://cassyni.com/events/FQjNLNLVkgMGuFcXMzredj?videoPreview=12025-06-30T16:00:00+00:003300.36Research Seminars by Springer NatureWe are pleased to invite ECRs to attend a focused, editor-led webinar on the principles and practices of writing a research paper suitable for peer review. In this session, participants will gain insights into the importance of publishing their research findings, organising the structure of a scientific paper, and presenting their results as a coherent scientific narrative. The presentation will be followed by a live Q&A where attendees have the opportunity to engage and receive feedback directly. This event is jointly organised by the editors in the ECR working group across the Nature Portfolio and the Reviewer Engagement team in Springer Nature. Image credit: [Glenn Carstens-Peters (Unsplash)](https://unsplash.com/photos/person-using-macbook-pro-npxXWgQ33ZQ).https://cassyni-user-files-prod.s3.amazonaws.com/FbqBJTVhxJeBEnaBjUWMBL https://cassyni.com/events/NKqT6ZujJT2nYYJW21N2R3/seminar/qa https://cassyni.com/slides/outline/NKqT6ZujJT2nYYJW21N2R3 https://cassyni.com/events/NKqT6ZujJT2nYYJW21N2R3/abstract https://cassyni-user-files-prod.s3.amazonaws.com/XVWRebeVqdfnuRLt4Hdahk https://cassyni.com/events/NKqT6ZujJT2nYYJW21N2R3?videoPreview=1 High-Order Finite Elements for Exascale Applicationsnohttps://cassyni.com/events/NKqT6ZujJT2nYYJW21N2R3?videoPreview=12025-06-25T13:00:00+00:004109.72Nektar++ Development TeamIn this talk we review our experience with porting the MFEM finite element library (https://mfem.org) to GPU-based exascale architectures. This development included both software and algorithmic changes, as well as co-design with hardware vendors and large-scale multi-physics applications as part of the US Exascale Computing Project (ECP). Modern architectures favor algorithms, such as high-order finite elements, that expose fine-grain parallelism and maximize the ratio of floating-point operations to energy intensive data movement. These methods are particularly well-suited for exascale architectures with GPU accelerators, where their efficiency and scalability rely on the adoption of partially assembled algorithms that reduce memory data motion. The matrix-free nature of partial assembly algorithms enables higher efficiency, but also motivates new research in areas such as meshing, discretizations and solvers. We will present some of the recent work on GPU-oriented algorithms and software in MFEM, and also report on developments in related projects, including high-order ALE compressible hydrodynamics in LLNL's BLAST code; GPU benchmarks from the Center for Efficient Exascale Discretizations in the ECP; and the Cascadia project for acoustic–gravity waves in tsunami modeling.https://cassyni-user-files-prod.s3.amazonaws.com/XVWRebeVqdfnuRLt4Hdahk https://cassyni.com/events/PKAHJZifaj4fMmpuQYmnrZ/seminar/qa https://cassyni.com/slides/outline/PKAHJZifaj4fMmpuQYmnrZ https://cassyni.com/events/PKAHJZifaj4fMmpuQYmnrZ/abstract https://cassyni-user-files-prod.s3.amazonaws.com/CBs4ZsurVVbxb6v7Uk6cQe https://cassyni.com/events/PKAHJZifaj4fMmpuQYmnrZ?videoPreview=1 Electrified Water Systems for Sustainable Water Supply and Waste Management: Electro-Deionizationnohttps://cassyni.com/events/PKAHJZifaj4fMmpuQYmnrZ?videoPreview=12025-07-29T09:00:00+00:003686.36ElsevierAs pressure mounts on global water systems due to climate change, growing populations, and resource constraints, the need for more sustainable and adaptive water treatment solutions is more apparent than ever. Electrified water treatment offers a compelling path forward. By using electrical energy to drive separation and redox reactions, these systems reduce dependence on chemical additives while allowing for fine control over treatment performance. Their ability to pair with renewable energy sources like solar and wind also makes them especially suitable for decentralized and off-grid settings. Among the various electrochemical methods, technologies such as electrocoagulation, electrooxidation, and electro-disinfection are gaining traction for their compact footprint and on-demand operation. In particular, Capacitive Deionization (CDI) and its advanced form, Flow-Electrode CDI (FCDI), are showing strong promise, not just for desalinating brackish water, but for tackling a much broader set of challenges. Recent developments in FCDI have pushed the boundaries of what electro-deionization can achieve. Beyond conventional desalination, FCDI has been successfully used to recover valuable resources like lithium and rare earth elements from battery leachates and acid mine drainage. It has also been applied to remove naturally occurring metals such as iron and manganese from groundwater. In some cases, FCDI has even been combined with advanced oxidation processes to create hybrid systems that handle both ionic and organic contaminants in a single step. These diverse applications highlight the flexibility of the technology and its potential to adapt to a wide range of water treatment needs. This talk will explore how FCDI is helping to shape the next generation of low-carbon, electrified water treatment systems. We will look at how it can be integrated with renewable energy, how it fits into modular and scalable treatment architectures, and how it works in synergy with other electrochemical processes. As the water sector moves toward net-zero goals, electro-deionization technologies like FCDI are emerging as key tools, offering energy efficiency, chemical reduction, and resilience in the face of today’s evolving environmental and resource challengeshttps://cassyni-user-files-prod.s3.amazonaws.com/CBs4ZsurVVbxb6v7Uk6cQe https://cassyni.com/events/15z6Doc3q89XHoMHqjLRrm/seminar/qa https://cassyni.com/slides/outline/15z6Doc3q89XHoMHqjLRrm https://cassyni.com/events/15z6Doc3q89XHoMHqjLRrm/abstract https://cassyni-user-files-prod.s3.amazonaws.com/PthjP8QRwd5SAr6uRLVV3k https://cassyni.com/events/15z6Doc3q89XHoMHqjLRrm?videoPreview=1 Focus on Immune Agingnohttps://cassyni.com/events/15z6Doc3q89XHoMHqjLRrm?videoPreview=12025-08-12T15:00:00+00:004762.52Nature AgingThe reshaping of the immune system which occurs during aging has detrimental consequences for tissue function and pathology. The August 2025 issue of Nature Aging provides a Focus on immune aging, featuring a series of reviews and opinion pieces on recent advances in immune aging research. This panel discussion hosted by Nature Aging with experts in the field accompanies the Focus issue, and covers emerging concepts in immune aging as well as translational therapies.https://cassyni-user-files-prod.s3.amazonaws.com/PthjP8QRwd5SAr6uRLVV3k https://cassyni.com/events/3ZE7TDqg2Qv1ejprPRF4ah/seminar/qa https://cassyni.com/slides/outline/3ZE7TDqg2Qv1ejprPRF4ah https://cassyni.com/events/3ZE7TDqg2Qv1ejprPRF4ah/abstract https://cassyni-user-files-prod.s3.amazonaws.com/BvsftW5rnerr7y2oSvW67Q https://cassyni.com/events/3ZE7TDqg2Qv1ejprPRF4ah?videoPreview=1 Quantum metrology and sensing with many-body systemsnohttps://cassyni.com/events/3ZE7TDqg2Qv1ejprPRF4ah?videoPreview=12025-09-10T12:00:00+00:003807.0Physics ReportsQuantum systems, fabricated across various spatial scales from nano to micrometers, are very delicate and naturally sensitive to the variations of their environment. These features make them excellent candidates for serving as sensors with wide range of applications. Indeed, the exceptional precision of quantum sensors arises from their compact size and inherent sensitivity, enabling measurements with unprecedented accuracy within highly localized regions. A key advantage of quantum sensors lies in their resource efficiency, as their achievable precision can scale super-linearly with respect to resources, such as system size, in contrast to the linear scaling characteristic of classical sensors. This phenomenon, commonly referred to as quantum-enhanced sensitivity, fundamentally depends on exploiting uniquely quantum mechanical features, including superposition, entanglement, and squeezing. Originally, quantum sensing was formulated for particles prepared in a special form of entangled states. Yet, certain realization of these probes may be susceptible to decoherence and interaction between particles may also be detrimental to their performance. An alternative framework for quantum sensing has been developed through exploiting quantum many-body systems, where the interaction between particles plays a crucial role. In this seminar, we investigate different aspects of the latter approach for quantum metrology and sensing. Many-body probes have been used for sensing purposes in both equilibrium and non-equilibrium scenarios. Quantum criticality, as a well-studied subject in many-body physics, has been identified as a resource for achieving quantum-enhanced sensitivity in both of these scenarios. In equilibrium, various types of criticalities, such as first order, second order, topological, and localization phase transitions have been exploited for sensing purposes. In non-equilibrium scenarios, quantum-enhanced sensitivity has been discovered for Floquet, dissipative, and time crystal phase transitions. While each type of these criticalities, either in equilibrium or non-equilibrium scenarios, has its own characteristics, the presence of one feature is crucial for achieving quantum-enhanced sensitivity and that is energy/quasi-energy gap closing. In non-equilibrium quantum sensing, time becomes another parameter which can affect the sensitivity of the probe. Typically, the sensitivity enhances as the probe evolves in time. In this review, we provide an overview on recent progresses on different aspects of quantum metrology and sensing with many-body systems.https://cassyni-user-files-prod.s3.amazonaws.com/BvsftW5rnerr7y2oSvW67Q https://cassyni.com/events/SmeGQ6DZrD6GBVbfizJRed/abstract https://cassyni-user-files-prod.s3.amazonaws.com/QFhrBSSUP8aNZ74RuT6Lei https://cassyni.com/events/BxC91aopgUUdsZJxiLUh6u/seminar/qa https://cassyni.com/events/BxC91aopgUUdsZJxiLUh6u/abstract https://cassyni-user-files-prod.s3.amazonaws.com/9JQJf6wfFFpQbNZ8huDGMU https://cassyni.com/events/BxC91aopgUUdsZJxiLUh6u?videoPreview=1 Applications of Nektar++ Inohttps://cassyni.com/events/BxC91aopgUUdsZJxiLUh6u?videoPreview=12025-06-24T14:00:00+00:006223.92Nektar++ Development TeamThis talk discusses the application of the high-fidelity spectral/hp element method using the open-source Nektar++ framework to simulate unsteady, transitional flow around complex 3D geometries representative of the Formula 1 industry. This study extends the work on a previously investigated industrial benchmark, the Imperial Front Wing (IFW), which is derived from the front wing and endplate design of the McLaren MP4-17D race car. A combined configuration of the IFW with a wheel in contact with a moving ground in a rolling state is considered, representing the first instance of such a configuration being simulated using higher-order methods. The rolling wheel, combined with the IFW (IFW-W), provides the most realistic industrial configuration to date. The spectral/hp element method is applied to this test case to solve the incompressible Navier-Stokes equations, simulating the flow at a Reynolds number of $2.2 \times 10^5$. Time-averaged results from the unsteady simulation are compared to experimental Particle Image Velocimetry (PIV) data to assess the model's fidelity, offering insights into its reliability for accurately representing key flow characteristics. This research addresses the challenges and requisites associated with achieving diverse levels of flow resolution using the under-resolved DNS/implicit LES approach. This study investigates transonic buffet over a supercritical aerofoil using implicit wall-resolved large eddy simulations (iWRLES) conducted with the high-order spectral/hp element framework Nektar++. The ONERA OAT15A aerofoil, a widely studied benchmark, is used to explore the unsteady shock wave-boundary layer interaction. The simulations capture the unsteady shock oscillations and match the experimental shock location more accurately than conventional Reynolds-Averaged Navier-Stokes (RANS) models. The effects of inflow turbulence were also investigated, offering a deeper insight into the onset of transonic buffet with respect to the turbulence boundary layer transition.https://cassyni-user-files-prod.s3.amazonaws.com/9JQJf6wfFFpQbNZ8huDGMU https://cassyni.com/slides/outline/afKP7mTfwdM7GLodqTQ2y https://cassyni.com/events/afKP7mTfwdM7GLodqTQ2y/abstract https://cassyni-user-files-prod.s3.amazonaws.com/BAGyPvYegGRKWh85ddXRFc https://cassyni.com/events/afKP7mTfwdM7GLodqTQ2y?videoPreview=1 Exploratory Clinical Pharmacology for Drug Repurposing: Feasible Approaches and Insightsnohttps://cassyni.com/events/afKP7mTfwdM7GLodqTQ2y?videoPreview=12025-02-27T06:00:00+00:004712.44The Pharmacological Research family of journalsJoin us for webinar from Prof. Ahmed El-Yazbi, Professor of Pharmacology and Therapeutics at Alamein International University, and Adjunct Professor of Chemistry and Biochemistry at Texas Tech University on the repurposing of drugs in clinical pharmacology. Prof. El-Yazbi graduated in 2001 from the Faculty of Pharmacy in Alexandria University, with a BPharm degree. He received his PhD in Pharmacology from the Faculty of Medicine at the University of Alberta in 2008. He was then awarded two fellowships from the Canadian Institutes for Health Research and Alberta Innovates-Health Solutions to conduct a research program studying the regulation of cerebral blood flow at the Hotchkiss Brain Institute at the University of Calgary. Dr. El-Yazbi has two board certifications in Clinical Pharmacy and Pharmacotherapy from Canadian and American Boards. Dr. El-Yazbi leads a large research group in Egypt and collaborates with multiple research partners nationally and internationally. His research uses multiple tools ranging from molecular studies to machine learning to focus on cardiometabolic pathophysiology, producing over 100 research articles and mentoring 25 post-graduate students. His translational research program investigates the mechanisms of cardiovascular dysfunction in metabolic disease and identifies targets for novel therapies.https://cassyni-user-files-prod.s3.amazonaws.com/BAGyPvYegGRKWh85ddXRFc https://cassyni.com/slides/outline/DSAaGGGHQD4cMn8UcR4z61 https://cassyni.com/events/DSAaGGGHQD4cMn8UcR4z61/abstract https://cassyni-user-files-prod.s3.amazonaws.com/49xqQMk1fNbzBCVrL2f4ce https://cassyni.com/events/DSAaGGGHQD4cMn8UcR4z61?videoPreview=1 Transforming the EMA during the times of COVIDnohttps://cassyni.com/events/DSAaGGGHQD4cMn8UcR4z61?videoPreview=12023-05-30T23:00:00+00:003258.16Business SchoolThe COVID-19 pandemic served as a catalyst for significant digital transformation within the Employers and Manufacturers Association (EMA) and the broader New Zealand manufacturing sector. The 138-year-old EMA rapidly pivoted its operations in response to a surge in daily member calls from 75–100 to 700, establishing a Microsoft Teams-based call centre and a Facebook community that garnered 1400 businesses within a week. This digital infrastructure expanded the EMA’s reach beyond its 7000 members, evolving to support businesses through subsequent natural disasters and leading to investments in dedicated community platforms and Microsoft Dynamics for enhanced data access. Concurrently, COVID-19 underscored the critical importance of New Zealand’s manufacturing sector. This recognition led to the development of an Advanced Manufacturing Industry Transformation Plan (ITP), focused on leveraging digital technologies as a horizontal capability across all manufacturing types. The ITP aims to foster globally competitive, scalable, and sustainable industries, driving higher wages and skilled employment, and acknowledging its significant role for Māori and Pacific communities. A case study illustrated a Bay of Plenty timber company’s use of a digital twin for just-in-time global delivery, demonstrating the profound transformative potential of digital solutions even in traditional sectors. To further this transformation, the adoption of financial incentives, such as accelerated depreciation schemes (e.g., 75% in the first year as seen in Singapore in 2021), is advocated to encourage investment in digital hardware, software, and skills development. Addressing the need for digitally-enabled talent across all age groups and finding a balance between digital and human engagement to safeguard well-being remain critical challenges.https://cassyni-user-files-prod.s3.amazonaws.com/49xqQMk1fNbzBCVrL2f4ce https://cassyni.com/slides/outline/CSsNAtyEXHxTh2JUWSbfH7 https://cassyni.com/events/CSsNAtyEXHxTh2JUWSbfH7/abstract https://cassyni-user-files-prod.s3.amazonaws.com/3K2oVEWxDLU1scn1xDEaQW https://cassyni.com/events/CSsNAtyEXHxTh2JUWSbfH7?videoPreview=1 Girish Ramachandran on Digital technology in a post-Covid worldnohttps://cassyni.com/events/CSsNAtyEXHxTh2JUWSbfH7?videoPreview=12020-09-01T23:00:00+00:003391.48Business SchoolThe post-COVID-19 era presents a unique opportunity to leverage digital technology to navigate the accelerating 4th Industrial Revolution and address global challenges. This analysis highlights three interconnected trends: a drive for national self-reliance, the ubiquity of digitization, and an imperative for sustainable development. Traditional business continuity plans proved insufficient during the pandemic, necessitating a re-evaluation of organizational "digital spines" built on connectivity, collaboration, cloud, and cybersecurity. Digital technology offers transformative potential across societal domains. It can reshape urbanization patterns, as demonstrated by models like TCS's "25 by 25" initiative, which suggests only 25% of the workforce needs to be in an office at any given time. In food security, technology such as IoT sensors and big data analytics can optimize supply chains, mitigating the issue of 3 billion people's worth of food being wasted annually, rather than focusing solely on increased production. For an aging global population, projected to double to 2 billion over 60 by 2050, non-intrusive sensors and data analytics can enable independent living. Healthcare delivery is being reimagined through online consultations and digital platforms like the "Digital Nerve Center" for cancer care. Furthermore, digital twins and blockchain can facilitate decarbonization and efficient resource use in the face of climate change. Ultimately, ensuring equitable access to technology and fostering "digital citizens" is critical to preventing socioeconomic division and achieving a more sustainable and prosperous future.https://cassyni-user-files-prod.s3.amazonaws.com/3K2oVEWxDLU1scn1xDEaQW https://cassyni.com/slides/outline/Krd3ynBzWXC2L5XLktPqKj https://cassyni.com/events/Krd3ynBzWXC2L5XLktPqKj/abstract https://cassyni-user-files-prod.s3.amazonaws.com/FeDLzEgbjzDhWmgF5xKrTQ https://cassyni.com/events/Krd3ynBzWXC2L5XLktPqKj?videoPreview=1 Networks of acoustic waveguides: effects of symmetry and topologynohttps://cassyni.com/events/Krd3ynBzWXC2L5XLktPqKj?videoPreview=12025-06-17T05:00:00+00:001627.2ETOPIMIn this work, we explore the wave properties of networks of slender acoustic waveguides exhibiting different symmetries (mirror, chiral or hidden). First, using the slenderness assumption of the connecting waveguides and not relying on a tight binding approximation, it will be shown how these networks can be directly mapped into typical discrete lattice systems with an Hamiltonian matrix depending only on geometrical parameters, and with a pseudo-energy linked to the frequency. Then, in these systems, it will be explored how eigenfrequencies [1-4] or scattering properties [5] follow interesting broadband and/or robustness properties inherited from the symmetries and associated topological aspects. Both the theory and the experimental realization, e.g. in acoustical context, will be discussed. https://cassyni-user-files-prod.s3.amazonaws.com/FeDLzEgbjzDhWmgF5xKrTQ https://cassyni.com/slides/outline/WEEjx8n1j8pSrapUmzLj1F https://cassyni.com/events/WEEjx8n1j8pSrapUmzLj1F/abstract https://cassyni-user-files-prod.s3.amazonaws.com/2vF2mdr82S45SQ2fXg6meN https://cassyni.com/events/WEEjx8n1j8pSrapUmzLj1F?videoPreview=1 Training all mechanical neural networks for task learning through in situ backpropagationnohttps://cassyni.com/events/WEEjx8n1j8pSrapUmzLj1F?videoPreview=12025-06-18T03:00:00+00:001728.68ETOPIMRecent advances unveiled physical neural networks as promising machine learning platforms, offering faster and more energy-efficient information processing. Compared with extensively-studied optical neural networks, the development of mechanical neural networks remains nascent and faces significant challenges, including heavy computational demands and learning with approximate gradients. Here, we introduce the mechanical analogue of in situ backpropagation to enable highly efficient training of mechanical neural networks. We theoretically prove that the exact gradient can be obtained locally, enabling learning through the immediate vicinity, and we experimentally demonstrate this backpropagation to obtain gradient with high precision. With the gradient information, we showcase the successful training of networks in simulations for behavior learning and machine learning tasks, achieving high accuracy in experiments of regression and classification. Furthermore, we present the retrainability of networks involving task-switching and damage, demonstrating the resilience. Our findings, which integrate the theory for training mechanical neural networks and experimental and numerical validations, pave the way for mechanical machine learning hardware and autonomous self-learning material systems.https://cassyni-user-files-prod.s3.amazonaws.com/2vF2mdr82S45SQ2fXg6meN https://cassyni.com/slides/outline/WitLzpRYAbNVrMMNNRdXGZ https://cassyni.com/events/WitLzpRYAbNVrMMNNRdXGZ/abstract https://cassyni-user-files-prod.s3.amazonaws.com/U7ynWHVMRy27jhn5qSBgxE https://cassyni.com/events/WitLzpRYAbNVrMMNNRdXGZ?videoPreview=1 Nonlocal metamaterialsnohttps://cassyni.com/events/WitLzpRYAbNVrMMNNRdXGZ?videoPreview=12025-06-20T01:00:00+00:003847.16ETOPIMI review our recent work on nonlocal metamaterials. After a brief introduction into nonlocality following Ref. [1], including different mechanisms and different mathematical ways of capturing it, I focus on two groups of examples: (i) propagating elastic waves at finite frequencies [2,3] as well as frozen evanescent elastic waves [4,5] and (ii) nonlocal dc Ohmic conduction in 1D metawires [6]. https://cassyni-user-files-prod.s3.amazonaws.com/U7ynWHVMRy27jhn5qSBgxE https://cassyni.com/slides/outline/RHkhVJJmLZHRTV78mWdjH7 https://cassyni.com/events/RHkhVJJmLZHRTV78mWdjH7/abstract https://cassyni-user-files-prod.s3.amazonaws.com/EH9vqMjC7xnhJsv2ZrQiR4 https://cassyni.com/events/RHkhVJJmLZHRTV78mWdjH7?videoPreview=1 Non-invasive focusing in chaotic cavity for plasma steeringnohttps://cassyni.com/events/RHkhVJJmLZHRTV78mWdjH7?videoPreview=12025-06-19T23:00:00+00:00636.16ETOPIMThis study addresses the challenge of achieving non-invasive spatiotemporal focusing within chaotic metallic cavities to enable precise plasma steering. Building on prior demonstrations of plasma ignition via time-reversal focusing on monopole antennas inside a low-pressure argon-filled cavity, the analysis explores a novel approach to focus energy at arbitrary locations without requiring a physical target. The method involves measuring the scattering matrices of two cavity configurations—empty and containing a small dielectric object—and computing their difference followed by Singular Value Decomposition (SVD) to extract the impulse response corresponding to the object's location. Numerical simulations using finite-difference time-domain modeling of a truncated disc cavity with multiple ports and transverse electric modes validate this approach. Results show that the SVD-derived impulse response closely matches the theoretical time-reversal signal, achieving a correlation coefficient of 0.97 in ideal conditions, thus enabling effective focalization comparable to time reversal. Parameter variations reveal that focalization quality depends on factors such as object permittivity, size, port number, and modal overlap, with small perturbations favoring successful focusing. Singular value spectra provide diagnostic insight into focalization feasibility when theoretical references are unavailable. Experimental efforts include constructing a 2 m³ copper reverberant cavity with a measured reverberation time of approximately 3 microseconds, where initial time-reversal experiments have been conducted. This framework offers a promising pathway toward full spatiotemporal control of plasma generation inside complex cavities, with implications for advanced plasma steering and manipulation technologies.https://cassyni-user-files-prod.s3.amazonaws.com/EH9vqMjC7xnhJsv2ZrQiR4 https://cassyni.com/slides/outline/DvsRYCwaePUCzwaccC28B7 https://cassyni.com/events/DvsRYCwaePUCzwaccC28B7/abstract https://cassyni-user-files-prod.s3.amazonaws.com/5avWcu3gdeKkV8un1TGbGz https://cassyni.com/events/DvsRYCwaePUCzwaccC28B7?videoPreview=1 Taking stock of the science of sciencenohttps://cassyni.com/events/DvsRYCwaePUCzwaccC28B7?videoPreview=12025-07-01T08:00:00+00:006095.84The seminar synthesizes contemporary perspectives on the science of science, emphasizing its evolution, current challenges, and future directions within global research systems. The analysis foregrounds the critical role of investment and human capital in shaping scientific leadership, highlighting the United States’ declining dominance amid rising Chinese R&D expenditure and shifting talent flows. Quantitative indicators such as gross domestic expenditure on R&D, PhD production, publication output, and citation impact reveal a transition from unipolar to polycentric scientific influence, with China surpassing the US in several metrics. However, funding cuts and restrictive immigration policies in the US threaten its capacity to attract and retain global talent, potentially accelerating a brain drain. The discussion also critiques the limitations of bibliometric indicators, underscoring their partial capture of scientific activity and embedded value judgments, and calls for more nuanced metrics that reflect collaboration, influence, and diplomacy rather than dominance. Reflections on metascience reveal persistent issues of reproducibility, research waste, and the politicization of science, with calls for embracing uncertainty, pluralism, and transparency in science policy. The seminar further explores national contexts, detailing Australia’s interdisciplinary metascience community and China’s state-led, institutionalized science of science framework closely integrated with policy planning. The collective insights advocate for a global, networked understanding of science that transcends competition, promotes open collaboration, and aligns research priorities with societal needs, emphasizing meta-science’s potential to inform equitable and effective science governance.https://cassyni-user-files-prod.s3.amazonaws.com/5avWcu3gdeKkV8un1TGbGz https://cassyni.com/events/2YqcuJT4SRgXEwASSbHrLD/seminar/qa https://cassyni.com/slides/outline/2YqcuJT4SRgXEwASSbHrLD https://cassyni.com/events/2YqcuJT4SRgXEwASSbHrLD/abstract https://cassyni-user-files-prod.s3.amazonaws.com/P2t13Udxs79TGp2zamJsDQ https://cassyni.com/events/2YqcuJT4SRgXEwASSbHrLD?videoPreview=1 SDG 5: Gender identity in Indigenous communitiesnohttps://cassyni.com/events/2YqcuJT4SRgXEwASSbHrLD?videoPreview=12025-09-10T09:00:00+00:002590.64Springer Nature Sustainable Development Goals ProgrammeThe SDG5 working group at Springer Nature is thrilled to host a panel discussion on “Gender identity in Indigenous communities”. This is a complex issue that involves a variety of factors, including colonial legacies, LGBTIQ+phobia and transphobia, and discrimination. In indigenous cultures, the concept of gender is less defined and has been like that for centuries. Many indigenous communities recognize the notion of a gender in between male and female or alternatively gender fluid. The event will feature experts who will delve into the challenges that Indigenous communities face in terms of social acceptance and legal recognition, exploring the ways Indigenous communities are working on to reclaim, preserve, or protect their gender identities. https://cassyni-user-files-prod.s3.amazonaws.com/P2t13Udxs79TGp2zamJsDQ https://cassyni.com/events/WhpgetqrrtAtG5oCmyhQgm/seminar/qa https://cassyni.com/slides/outline/WhpgetqrrtAtG5oCmyhQgm https://cassyni.com/events/WhpgetqrrtAtG5oCmyhQgm/abstract https://cassyni-user-files-prod.s3.amazonaws.com/7Ld5sj9xPKNNLTW5JyF5hp https://cassyni.com/events/WhpgetqrrtAtG5oCmyhQgm?videoPreview=1 21st international Biometals Webinarsnohttps://cassyni.com/events/WhpgetqrrtAtG5oCmyhQgm?videoPreview=12025-12-02T14:00:00+00:005541.2BioMetalsThe 21st International Biometals Webinar featured two distinct yet complementary perspectives on the role of metals in biology, addressing both contemporary bioinorganic chemistry and the origins of life. The first presentation detailed the development and application of liquid chromatography (LC)-based metallomics tools to investigate toxic metal species in mammalian blood plasma, focusing on exposure–disease relationships at the blood–organ interface. Using size-exclusion and reversed-phase chromatography coupled with inductively coupled plasma atomic emission spectrometry (ICP-AES), the study elucidated mechanisms of methylmercury transport from blood to brain, identifying homocysteine as a chaperone facilitating methylmercury translocation across the blood–brain barrier. Additional findings revealed that toxic metals such as mercury and cadmium bind to hemoglobin and carbonic anhydrase released upon red blood cell rupture, implicating these metalloproteins in disease processes like neurotoxicity and atherosclerosis. The second presentation challenged the prevailing organic-centric paradigm of life’s emergence by emphasizing the fundamental and catalytic roles of transition metals in bioenergetics and enzyme function. It argued that life is as much “metallic” as organic, with transition metal ions mediating redox reactions essential for free energy conversion and low-entropy maintenance. This metallic perspective suggests that the origin of life was driven by metal-containing minerals harnessing environmental redox gradients, providing a thermodynamically plausible pathway distinct from the classical “primordial soup” hypothesis. Together, these contributions underscore the critical importance of metals in both understanding disease mechanisms and re-evaluating life’s biochemical and evolutionary foundations.https://cassyni-user-files-prod.s3.amazonaws.com/7Ld5sj9xPKNNLTW5JyF5hp https://cassyni.com/events/GQ7SmdBCqgEhMt4B9svku3/abstract https://cassyni-user-files-prod.s3.amazonaws.com/F5vo5i3rwdF8qZ31xfpDDY https://cassyni.com/slides/outline/4XQQyQXGntyBnQeVCB5Wsw https://cassyni.com/events/4XQQyQXGntyBnQeVCB5Wsw/abstract https://cassyni-user-files-prod.s3.amazonaws.com/5rCLwYXtLDBrgpikcmY9fk https://cassyni.com/events/4XQQyQXGntyBnQeVCB5Wsw?videoPreview=1 Label-Free Detection of HIV-1 Drug-Resistant Mutations Using Localized Surface Plasmon Resonancenohttps://cassyni.com/events/4XQQyQXGntyBnQeVCB5Wsw?videoPreview=12025-08-14T15:00:00+00:002498.68NoneDespite significant progress in the global HIV response—with a 40% reduction in new infections since 2010 and 89% of diagnosed individuals on antiretroviral therapy (ART)—the emergence of HIV drug-resistant strains threatens long-term treatment efficacy, particularly in resource-limited settings. While conventional molecular techniques have enabled detailed resistance profiling, they remain expensive, time-consuming, and inaccessible in many low-resource or rural areas. This talk presents a novel application of Localized Surface Plasmon Resonance (LSPR) for detecting HIV-1 drug resistance mutations. Our system demonstrated the ability to detect single-nucleotide polymorphisms via partial hybridization of ssDNA targets, yielding a distinct peak wavelength shift of 3 RIU—indicating high sensitivity. These results suggest that LSPR could form the basis for a low-cost, rapid, and scalable point-of-care assay, enabling earlier detection of resistance and better treatment outcomes in high-burden regions. Taliya Weinstein, Programming Chair of the Data Science for Health in Africa Workshop 2025 from SisonkeBiotik will chair this seminar. Image credit: [Sangharsh Lohakare (Unsplash)](https://unsplash.com/photos/a-close-up-of-a-blue-and-purple-structure-8o_LkMpo8ug).https://cassyni-user-files-prod.s3.amazonaws.com/5rCLwYXtLDBrgpikcmY9fk https://cassyni.com/slides/outline/CvRgm2XCFgPAwjzxG2Qa6q https://cassyni.com/events/CvRgm2XCFgPAwjzxG2Qa6q/abstract https://cassyni-user-files-prod.s3.amazonaws.com/LZ1t8sfB71mMEsrNMyLh2E https://cassyni.com/events/CvRgm2XCFgPAwjzxG2Qa6q?videoPreview=1 Equity for Women in Science at the University of Grenadanohttps://cassyni.com/events/CvRgm2XCFgPAwjzxG2Qa6q?videoPreview=12023-06-06T08:00:00+00:002970.96 School of Public PolicyThis analysis addresses persistent gender inequities in scientific research, focusing on authorship, funding, collaboration, mobility, and impact across disciplines and countries from 2008 to 2020. Utilizing a refined gender-assignment algorithm applied to bibliometric data, the study reveals significant disparities in women’s participation and recognition in science. Women’s authorship remains below parity globally, with notable exceptions in some Eastern European and Latin American countries, where demographic factors such as male mortality influence gender balance. Productivity gaps persist, especially in STEM fields like engineering and physics, where projections suggest over a century to reach parity. Women disproportionately perform experimental work and write original drafts, while men dominate conceptual tasks, funding acquisition, and supervision. Funding analyses indicate that although women in some fields hold grants at comparable or higher rates, the average grant amounts awarded to women are lower, particularly in medical sciences. Mobility patterns show men are more likely to migrate and hold multiple affiliations, enhancing visibility and citation impact. Women’s research tends to be more nationally focused and less cited, with the largest citation gaps occurring in high-impact journals, suggesting systemic bias beyond self-citation differences. Parenting responsibilities disproportionately borne by women correlate with reduced productivity and visibility. Importantly, increased diversity in research teams correlates with broader inclusion of sex, race, and ethnicity in study designs, influencing research topics and societal relevance. The findings underscore the need for systemic reforms across funding, publishing, institutional policies, and cultural norms to create an equitable scientific enterprise that better represents and serves diverse populations.https://cassyni-user-files-prod.s3.amazonaws.com/LZ1t8sfB71mMEsrNMyLh2E https://cassyni.com/events/Bw8UffE9NmH2GzAxA3wFHw/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Jof8qg6aNDbnPcs5YrDqxS https://cassyni.com/slides/outline/NJmnkeL3zjqAwyAVTipac5 https://cassyni.com/events/NJmnkeL3zjqAwyAVTipac5/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Br9Ntso3FwMRrsUu9ceHbt https://cassyni.com/events/NJmnkeL3zjqAwyAVTipac5?videoPreview=1 AI and the Future of Med Ed: Recommendations from the Macy Foundation Conferencenohttps://cassyni.com/events/NJmnkeL3zjqAwyAVTipac5?videoPreview=12025-06-12T08:00:00+00:003549.68AAMCAI presents powerful opportunities and challenges for academic medicine. The [September 2025 Academic Medicine supplement](https://journals.lww.com/academicmedicine/toc/2025/09001) outlines key recommendations from the 2024 Josiah Macy Jr. Foundation Conference to help educators move forward thoughtfully. Join AAMC’s Chief Academic Officer, Dr. Alison Whelan, and contributors to the report for a focused, interactive webinar on practical implementation. This webinar is part of the Artificial Intelligence in Academic Medicine Webinar Series, hosted by the AAMC. It explores critical concepts, the current landscape, and practical strategies drawn from various perspectives and institutions to support you in navigating the evolving world of AI in academic medicine. For more information, see [the complete series webpage](https://www.aamc.org/about-us/mission-areas/medical-education/artificial-intelligence-ai-academic-medicine-webinar-series). https://cassyni-user-files-prod.s3.amazonaws.com/Br9Ntso3FwMRrsUu9ceHbt https://cassyni.com/slides/outline/HNHkHorocAJ9YsT9TF7asw https://cassyni.com/events/HNHkHorocAJ9YsT9TF7asw/abstract https://cassyni-user-files-prod.s3.amazonaws.com/4zHowERoWMSJwGNtpQRv6z https://cassyni.com/events/HNHkHorocAJ9YsT9TF7asw?videoPreview=1 Information Policy and Management: L2 Skills and Uncertainty Reductionnohttps://cassyni.com/events/HNHkHorocAJ9YsT9TF7asw?videoPreview=12019-07-26T08:00:00+00:00706.6 School of Public PolicyThis analysis examines the role of labor skills in organizational information processing and uncertainty reduction, emphasizing how different types of skills correspond to specific uncertainties faced by organizations. Skills function by enabling workers to diagnose, classify, and address problems through routines shaped by training and experience. These routines vary in complexity—both external (task decomposition) and internal (design and debugging)—and in flexibility, reflecting the worker’s ability to adapt to changing circumstances. Two broad categories of routines are identified: batch processing, characterized by fixed, repetitive procedures suitable for stable, predictable tasks (e.g., assembly lines), and interactive processing, requiring stepwise decision-making and adaptability, typical in education and professional services. Workers are categorized by skill level—from craft persons who learn primarily through supervised practice, to junior professionals trained in theoretical principles, to senior professionals who adapt and innovate routines strategically. The composition of these skill types within an organization reveals its approach to managing uncertainty. Historically, skill organization evolved from guild-based systems through Fordism’s mechanized, segmented labor suited to stable markets, to contemporary knowledge work emphasizing discretion and scientific judgment. Fordism effectively manages uncertainties in stable production and demand but struggles with rapid market, product, or technological changes, highlighting the need for more flexible skill configurations in dynamic environments. This framework elucidates how skill structures and routines underpin organizational strategies for uncertainty reduction and information management.https://cassyni-user-files-prod.s3.amazonaws.com/4zHowERoWMSJwGNtpQRv6z https://cassyni.com/slides/outline/ViVrSu2vac91SYgxRbgK25 https://cassyni.com/events/ViVrSu2vac91SYgxRbgK25/abstract https://cassyni-user-files-prod.s3.amazonaws.com/4jwPJG69tGEadSQCTD97B4 https://cassyni.com/events/ViVrSu2vac91SYgxRbgK25?videoPreview=1 IWF Discussion on AInohttps://cassyni.com/events/ViVrSu2vac91SYgxRbgK25?videoPreview=12024-01-13T09:00:00+00:003618.68 School of Public PolicyThis seminar explores the multifaceted implications of artificial intelligence (AI) across business, legal, ethical, educational, and societal domains, emphasizing both its transformative potential and inherent risks. The discussion highlights the rapid adoption of AI technologies such as ChatGPT, noting their pervasive use even in environments where formal policies restrict them. Key challenges include managing biases embedded in training data, ensuring data quality, and addressing ethical and legal concerns, particularly regarding privacy and cybersecurity. The panel underscores the necessity of targeted, ongoing training for users to responsibly harness AI’s capabilities, stressing that AI deployment is fundamentally a business decision driven by clear objectives rather than a purely technological choice. The recent U.S. executive order on AI is examined as a strategic framework directing federal agencies to regulate and promote safe, transparent AI use, with an emphasis on public-private collaboration and risk management standards. Educational implications are considered, advocating for curricular reforms that integrate ethics and data stewardship into engineering and business programs to prepare future professionals for responsible AI development and application. The conversation also addresses broader societal impacts, including AI’s influence on democracy through misinformation and the evolving nature of work amid automation. While acknowledging uncertainties about the timeline for artificial general intelligence, the seminar concludes that AI’s long-term effects will be profound, necessitating vigilant oversight, ethical governance, and informed public engagement to maximize benefits and mitigate harms.https://cassyni-user-files-prod.s3.amazonaws.com/4jwPJG69tGEadSQCTD97B4 https://cassyni.com/events/RGh39Nj62r5osDYyB4hchK/seminar/qa https://cassyni.com/slides/outline/RGh39Nj62r5osDYyB4hchK https://cassyni.com/events/RGh39Nj62r5osDYyB4hchK/abstract https://cassyni-user-files-prod.s3.amazonaws.com/BsQNZv6hoH49XP8q3ZgMNv https://cassyni.com/events/RGh39Nj62r5osDYyB4hchK?videoPreview=1 Transnational Studies of 19th-Century Japanese and British Sciencenohttps://cassyni.com/events/RGh39Nj62r5osDYyB4hchK?videoPreview=12025-11-18T12:00:00+00:003748.72Royal Society PublishingThis seminar will discuss a recent special issue that focuses on the complex cultural connections between Japanese and British science in the nineteenth century. This was a period when intellectuals around the globe began to interact more intensively due to increased opportunities to travel and the growth in translations of important scientific works into many languages. This was also an era when, in the latter part of the century, Japanese intellectuals were searching for ways to modernize their culture, while in Britain there was a renewed interest in Japanese culture and religion as traditional forms of thought were being questioned. Although there has been some excellent scholarly work on the impact of British evolutionary theory on Japanese intellectuals, the fuller picture of cultural exchange across all the sciences has yet to be undertaken. This special issue will begin to close this historiographical gap by examining the intersection of nineteenth-century Japanese and British science across a range of disciplines from engineering, chemistry and physics to biology, sociology and anthropology.https://cassyni-user-files-prod.s3.amazonaws.com/BsQNZv6hoH49XP8q3ZgMNv https://cassyni.com/slides/outline/TFFqDUoJPKNUQPTAxosx1s https://cassyni.com/events/TFFqDUoJPKNUQPTAxosx1s/abstract https://cassyni-user-files-prod.s3.amazonaws.com/P1vk1Z2a8Ci9pmZ8Nzxs3U https://cassyni.com/events/TFFqDUoJPKNUQPTAxosx1s?videoPreview=1 Increasing Trust in AI: Approaches and Limitationsnohttps://cassyni.com/events/TFFqDUoJPKNUQPTAxosx1s?videoPreview=12021-09-22T08:00:00+00:005363.48 School of Public PolicyThis seminar addresses the critical issue of trust in artificial intelligence (AI) by examining conceptual, ethical, and practical dimensions. The discussion begins with an analysis of trust and overtrust phenomena, highlighting how users may attribute capabilities to AI systems beyond their actual functions, thereby accepting undue risks. Examples include reliance on chatbots for mental health support and self-driving vehicles, where misplaced trust can lead to harm. The importance of trust calibration—aligning user trust with system capabilities—is emphasized, alongside factors influencing trust such as emotional attachment and user diversity. A philosophical framework distinguishes between functional agency of AI systems and the vulnerable moral agency of humans, underscoring that AI lacks subjectivity, moral understanding, and accountability, thus can only be metaphorically trustworthy. Trustworthiness in AI is linked to reliability, safety, transparency, and ethical design, but human trust involves vulnerability and relational dynamics that AI cannot reciprocate. The seminar further presents a pragmatic assessment methodology, the “set inspection” process, developed to evaluate AI systems’ ethical, legal, and technical implications in real-world contexts. This multidisciplinary approach applies established ethical principles and requirements to guide design, deployment, and monitoring, illustrated by case studies including emergency medical dispatch AI and dermatological diagnostic tools. Findings reveal challenges such as undertrust by users, bias due to training data limitations, and conflicting expert opinions on AI utility. The work underscores the necessity of nuanced, context-sensitive trust frameworks and collaborative, evidence-based evaluation to foster responsible AI integration while mitigating harm.https://cassyni-user-files-prod.s3.amazonaws.com/P1vk1Z2a8Ci9pmZ8Nzxs3U https://cassyni.com/slides/outline/7yyGQpZqGTmbdoQg3WHeKf https://cassyni.com/events/7yyGQpZqGTmbdoQg3WHeKf/abstract https://cassyni-user-files-prod.s3.amazonaws.com/BWNX3AaJKshpKN45WWe7CJ https://cassyni.com/events/7yyGQpZqGTmbdoQg3WHeKf?videoPreview=1 Nano Social Science: An Emerging Specializationnohttps://cassyni.com/events/7yyGQpZqGTmbdoQg3WHeKf?videoPreview=12009-02-25T09:00:00+00:001239.64 School of Public PolicyOur group at Georgia Tech (Alan L. Porter, Philip Shapiro and Jan Youtie) continues to analyze an expanding compilation of nanoscience and nanoengineering (“nano”) research literature from three databases, as well as nanopatents. We have recently updated our Science Citation Index nano search through mid-year 2008; it contains 508,000 article abstracts dating from 1991. We have now compiled counterpart nano searches in the Social Science Citation Index, Arts & Humanities Citation Index, and Scopus – totaling 307 articles. We profile this small, but rapidly growing, literature to explore the development of social sciences addressing nanotechnology. We find evidence that social scientists are increasingly drawing on their own body of literature, whereas in earlier years they drew relatively more heavily upon the nano science and engineering literatures. Bibliometric analyses identify a contingent of some 60 authors whose work is heavily cited by the nano social science literature. We parse them into eight dimensions and explore the literature’s changing emphases. Our results support the hypothesis that social studies of nano are coalescing into a research network in their own right.https://cassyni-user-files-prod.s3.amazonaws.com/BWNX3AaJKshpKN45WWe7CJ https://cassyni.com/events/LLEcoAmj3dUEZGxgxYagv9/abstract https://cassyni-user-files-prod.s3.amazonaws.com/JcyC2fAmTkoekvFam17BLz https://cassyni.com/slides/outline/33VDwz6astEaEhhL32aebX https://cassyni.com/events/33VDwz6astEaEhhL32aebX/abstract https://cassyni-user-files-prod.s3.amazonaws.com/LCWrn5vcHU1sUAcyYLYk8N https://cassyni.com/events/33VDwz6astEaEhhL32aebX?videoPreview=1 Meta-fibres: Optical fibres with meta-surfaces for hair-thin imaging devicesnohttps://cassyni.com/events/33VDwz6astEaEhhL32aebX?videoPreview=12025-11-19T15:00:00+00:002808.64UK Microsystems NetworkOptical endoscopes are widely used in medicine to identify early-stage cancers in accessible parts of the body, such as the gastrointestinal tract, enabling early treatment and better patient outcomes. However, the next generation of endoscopes must overcome two key challenges to have a truly transformative impact. The first is size: hair-thin endoscopes would vastly expand the range of the body that can be examined in detail with minimal invasiveness, e.g. inside organs such as the pancreas via a needle, or inside tiny blood capillaries. The second is contrast: when imaging large regions it is difficult to identify subtle tissue changes indicative of early cancer. To overcome this, we have been developing a new type of endoscope that produces images through optical fibres: flexible hair-thin pieces of glass. This is achieved by combining two key technologies: holographic control of light in fibres and nanostructured optical metasurfaces. Together, these two technologies enable the implementation of advanced microscopy modalities in a hair-thin form factor. This makes high-contrast optical imaging deep inside the body possible. In this talk I will introduce the fundamentals of our fibre imaging technique and show how it can achieve quantitative phase and polarimetric imaging of tissue. I will then show how using nano-structured optical metasurfaces and computational optics techniques (including AI) will enable future clinical translation of this technology.https://cassyni-user-files-prod.s3.amazonaws.com/LCWrn5vcHU1sUAcyYLYk8N https://cassyni.com/events/9xZgbZ9w2HzMjWguQU9akD/abstract https://cassyni-user-files-prod.s3.amazonaws.com/8U2mbq4xNkfzNwba3iLkxN https://cassyni.com/slides/outline/61QULiVcuzUw6dWUFm7K17 https://cassyni.com/events/61QULiVcuzUw6dWUFm7K17/abstract https://cassyni-user-files-prod.s3.amazonaws.com/71hwNWstrMKuSWp8LFMGBY https://cassyni.com/events/61QULiVcuzUw6dWUFm7K17?videoPreview=1 A path to Covid-19 vaccine equitynohttps://cassyni.com/events/61QULiVcuzUw6dWUFm7K17?videoPreview=12022-04-20T06:00:00+00:004118.52Part of the nonprofit Annual Reviews organizationThe rapid development of safe and effective Covid-19 vaccines has led to the vaccination of more than half the world’s population over the past two years — an unprecedented public health achievement. But the uneven distribution of vaccines has created a stark gap in protection between different countries: While more than 70 percent of the citizens of Brazil, Canada and China are fully vaccinated, for example, fewer than 1 in 10 people have received a single dose in many African countries. In addition to creating a humanitarian crisis, this unequal distribution of vaccines favors the rise of new viral variants, threatening public health everywhere. Why has COVAX, the international initiative created to make sure all countries have access to vaccines, failed to reach that goal? What can be done to get doses to vulnerable populations?https://cassyni-user-files-prod.s3.amazonaws.com/71hwNWstrMKuSWp8LFMGBY https://cassyni.com/slides/outline/14vRst2NXQwuhXo8FHQKGy https://cassyni.com/events/14vRst2NXQwuhXo8FHQKGy/abstract https://cassyni-user-files-prod.s3.amazonaws.com/THk6DHCVntC4zhUrW7ufuY https://cassyni.com/events/14vRst2NXQwuhXo8FHQKGy?videoPreview=1 Unveiling the Sunnohttps://cassyni.com/events/14vRst2NXQwuhXo8FHQKGy?videoPreview=12025-02-19T06:00:00+00:002712.28Leeds Institute for Fluid DynamicsThe space age ushered in a new era of solar physics, in which the full extent and character of the Sun was revealed. Perhaps most notable was the discovery of huge plasma eruptions from the Sun, that are known as coronal mass ejections. This talk will take a look at the importance of space-based data in studying the Sun and will discuss the latest research that shows coronal mass ejections are caused by magnetic fields in the Sun's atmosphere that have been deformed into twisted ropes of magnetism that the Sun struggles to hold down.https://cassyni-user-files-prod.s3.amazonaws.com/THk6DHCVntC4zhUrW7ufuY https://cassyni.com/events/6W5hW2f2koxkv6Vz3sEHBK/abstract https://cassyni-user-files-prod.s3.amazonaws.com/QC7FiLrdj76fBkrr9Rk2ea https://cassyni.com/slides/outline/3YAT7JFzihiQ4UGgnyJwzu https://cassyni.com/events/3YAT7JFzihiQ4UGgnyJwzu/abstract https://cassyni-user-files-prod.s3.amazonaws.com/PxviSFtRtFycvZFYBaWWXg https://cassyni.com/events/3YAT7JFzihiQ4UGgnyJwzu?videoPreview=1 Distributed optimal control for fluid-structure interaction problemsnohttps://cassyni.com/events/3YAT7JFzihiQ4UGgnyJwzu?videoPreview=12021-02-24T06:00:00+00:001055.08Leeds Institute for Fluid DynamicsThis study addresses the distributed optimal control of fluid-structure interaction (FSI) problems, focusing on manipulating the motion of a deformable solid disc within a lid-driven cavity flow. The problem is governed by coupled partial differential equations describing an incompressible Newtonian fluid and an incompressible neo-Hookean viscoelastic solid, with the control variable represented by a distributed forcing term acting on the solid. The objective is to minimize the discrepancy between the actual and desired solid displacement while regularizing the control force magnitude to prevent unbounded inputs. A piecewise-in-time control approach is employed, minimizing the objective at each time step, despite the lack of formal proof for solution existence or stability in this context. The constrained optimization problem is tackled using a Lagrange multiplier framework, introducing adjoint variables to incorporate the PDE constraints. A monolithic numerical scheme is developed, integrating primal and adjoint equations into a single system solved via a one-velocity-field, two-mesh finite element method. This approach facilitates handling large solid deformations by coupling a stationary fluid mesh with a moving solid mesh through interpolation matrices. Numerical results demonstrate effective control of the solid’s position, achieving approximately 80% reduction in the objective function across different control points and times. The findings highlight the potential of distributed optimal control combined with advanced numerical schemes for managing complex FSI systems, with implications for improved manipulation and stabilization of deformable structures in fluid environments.https://cassyni-user-files-prod.s3.amazonaws.com/PxviSFtRtFycvZFYBaWWXg https://cassyni.com/events/FtNZGPS7h9ZFx9WVmKsg93/seminar/qa https://cassyni.com/slides/outline/FtNZGPS7h9ZFx9WVmKsg93 https://cassyni.com/events/FtNZGPS7h9ZFx9WVmKsg93/abstract https://cassyni-user-files-prod.s3.amazonaws.com/SNvTU4apBuL8aqEtW4Dbwk https://cassyni.com/events/FtNZGPS7h9ZFx9WVmKsg93?videoPreview=1 Particle acceleration in 3D simulations of perpendicular shocksnohttps://cassyni.com/events/FtNZGPS7h9ZFx9WVmKsg93?videoPreview=12025-10-30T15:00:00+00:002920.64Journal of Plasma PhysicsUnderstanding the mechanisms that drive particle acceleration at collisionless, non-relativistic shocks such as those in supernova remnants is essential for unveiling the origin of cosmic rays. While parallel shocks are known to efficiently accelerate particles, it has long been unclear whether perpendicular and oblique shocks where the shock normal is nearly perpendicular to the background magnetic field can do the same. Earlier 1D and 2D simulations of such shocks consistently failed to show ion acceleration. Yet, multiple observations suggest that perpendicular shocks can indeed accelerate particles at least up to GeV energies. In this talk I will show how we use hybrid simulations (kinetic ions–fluid electrons) to study particle acceleration and magnetic field amplification at non-relativistic, weakly magnetized, perpendicular shocks. Whereas no self-consistent kinetic simulation has previously reported energetic ions, our 3D simulations demonstrate that protons spontaneously develop a nonthermal tail unlike in 2D undergoing rapid acceleration via shock drift acceleration. I will discuss the implications of these findings for heliospheric shocks, supernova remnants, and radio supernovae. Furthermore, the growing interest in reproducing collisionless shocks in laboratory experiments using high-power lasers offers a unique opportunity to study these systems in controlled environments. I will discuss the implications of our results for conditions relevant to laboratory experiments.https://cassyni-user-files-prod.s3.amazonaws.com/SNvTU4apBuL8aqEtW4Dbwk https://cassyni.com/events/ATEuksKLs7UBZHGGAQst9b/abstract https://cassyni-user-files-prod.s3.amazonaws.com/NfUghpcPgWzsp243Yes4y4 https://cassyni.com/slides/outline/MKXptY4mvYaPE2nh4X41j3 https://cassyni.com/events/MKXptY4mvYaPE2nh4X41j3/abstract https://cassyni-user-files-prod.s3.amazonaws.com/RCtUEQBTbcoStSNMYaA6Rc https://cassyni.com/events/MKXptY4mvYaPE2nh4X41j3?videoPreview=1 Heat transport in the intra-cluster medium: the impact of microphysics on the large-scale dynamics in the periphery of galaxy clustersnohttps://cassyni.com/events/MKXptY4mvYaPE2nh4X41j3?videoPreview=12025-11-06T16:00:00+00:003152.84Journal of Plasma PhysicsThe intracluster medium (ICM) is a high-beta weakly-collisional plasma that plays a central role in many key processes that shape the evolution of galaxy clusters. Recent work has focused on two interlinked aspects: the preferential transport of heat and momentum along magnetic field lines on macroscopic (fluid) scales, the impact on particle transport of plasma instabilities on kinetic scales. Anisotropic heat conduction renders the periphery of galaxy clusters buoyantly unstable. The ensuing instability, called magneto-thermal instability (MTI), can contribute to the observed turbulence in galaxy clusters. Our recent work on the MTI shows that the strength of the turbulence is linked to the plasma thermal conductivity. This property renders the MTI sensitive to the action of kinetic instabilities that can slow down the thermal electrons: in particular, particle-in-cell (PIC) simulations suggest that whistler waves may significantly suppress thermal conductivity below its nominal Spitzer value. This scenario, where the MTI responds to whistler-wave suppression, is further explored with idealized MHD simulations with a subgrid closure for the heat flux inspired from kinetic theory. MTI turbulence with whistler suppression exhibits a critical transition as the plasma collisionality decreases and turbulence dies out. In the ICM, however, turbulence can be excited through other means such as shocks and mergers. While usually thought of as deleterious for the MTI, external turbulence with whistler-suppressed thermal conductivity can revive a “dead” MTI, keeping the plasma buoyantly unstable.https://cassyni-user-files-prod.s3.amazonaws.com/RCtUEQBTbcoStSNMYaA6Rc https://cassyni.com/slides/outline/HrzbZkY6rLhkCLV8Qrg4CD https://cassyni.com/events/HrzbZkY6rLhkCLV8Qrg4CD/abstract https://cassyni-user-files-prod.s3.amazonaws.com/3h1AJVt3YEFYoRrNRH4kFp https://cassyni.com/events/HrzbZkY6rLhkCLV8Qrg4CD?videoPreview=1 The ecology and evolution of Nicotiana section Suaveolentesnohttps://cassyni.com/events/HrzbZkY6rLhkCLV8Qrg4CD?videoPreview=12025-08-06T13:15:00+00:00791.2None*Nicotiana* section *Suaveolentes* (Solanaceae) contains approximately 80 wild tobacco species, originating in South America 5-6 million years ago. Today, species are found in Australia, some Pacific Islands, and Namibia. This monophyletic group diversified rapidly across Australia in the last 1-2 million years, despite the region’s relatively stable climate with some ephemeral, xerophytic species, while others are less arid-adapted perennials. The drivers of this diversification remain unclear. We hypothesise that closely related taxa occupy similar environmental niches, while distantly related species may occupy divergent ones. However, ecological factors like pollinators or microhabitat differentiation could also influence speciation, leading to divergent niches even among closely related taxa. The group has an allotetraploid origin (*n=24*), with species displaying varying chromosome numbers (reducing to *n=14*), offering a unique system to study the role of chromosomal rearrangement in niche divergence. Concurrently, the insular distributions of some taxa offer insights into gene flow and isolation, plus the section's disjunct distribution. Using spatial analysis, we quantify environmental niches and investigate divergence versus conservatism in recent speciation. Phylogenetic and population genomic tools illuminate species relationships, species delimitation, gene flow, and distribution patterns, especially in island populations. Our findings contribute to understanding the evolution and ecology of *Suaveolentes*, which may reveal broad macroevolutionary patterns common to other angiosperm groups.https://cassyni-user-files-prod.s3.amazonaws.com/3h1AJVt3YEFYoRrNRH4kFp https://cassyni.com/events/JrKRmkM38cjd1a1XoQ5pdj/seminar/qa https://cassyni.com/events/JrKRmkM38cjd1a1XoQ5pdj/abstract https://cassyni-user-files-prod.s3.amazonaws.com/CALNzyigqqnLqVUZv79T8a https://cassyni.com/events/JrKRmkM38cjd1a1XoQ5pdj?videoPreview=1 Effective models of metainterfaces made of three-dimensional Helmholtz resonatorsnohttps://cassyni.com/events/JrKRmkM38cjd1a1XoQ5pdj?videoPreview=12026-01-13T14:00:00+00:002989.04MetaMATWe investigate the behaviour of metainterfaces composed of three-dimensional subwavelength Helmholtz resonators (HRs), that are open at both ends and may have distinct neck geometries, using a homogenized model derived from a three-scale asymptotic approach. This model reduces such metainterfaces to homogenized boundary conditions that incorporate a resonant pressure field, providing a continuous representation of the discrete pressure field within the cavities that constitute the metasurface. Notable special cases include mirror- symmetric metainterfaces and metasurfaces that operate solely in reflection. The model, developed in the time domain, is validated and discussed in the harmonic regime through comparisons with direct numerical simulations.https://cassyni-user-files-prod.s3.amazonaws.com/CALNzyigqqnLqVUZv79T8a https://cassyni.com/events/UjFtanmeWQtDicKA2Puk93/abstract https://cassyni-user-files-prod.s3.amazonaws.com/BHMfWGvyjQB5mYQ1Ln4CVL https://cassyni.com/events/TjxgVRUbdVn53rV9vRSRL9/seminar/qa https://cassyni.com/slides/outline/TjxgVRUbdVn53rV9vRSRL9 https://cassyni.com/events/TjxgVRUbdVn53rV9vRSRL9/abstract https://cassyni-user-files-prod.s3.amazonaws.com/XfFB6vAxTvzHMR1AdEzMUz https://cassyni.com/events/TjxgVRUbdVn53rV9vRSRL9?videoPreview=1 Breaking Biological Barriers nohttps://cassyni.com/events/TjxgVRUbdVn53rV9vRSRL9?videoPreview=12026-01-12T15:00:00+00:004199.44Night Science InstituteIn my talk I will discuss recent work from my lab about transgenerational epigenetic inheritance, showing how, at least in nematodes, experiences can be transmitted across generations through small RNAs, altering behavior and physiology in descendants. I will connect these findings to broader questions about how biological information persists, discussing ancient DNA that records vanished worlds, and brain parasites that manipulate their hosts, and also molecular mechanisms that delay forgetting. Along the way, I will discuss “Night Science Moments”, sharing how some of these ideas first emerged, those unplanned moments when curiosity, coincidence, and imagination reshaped the path of our research. I will also discuss my attempts to influence science communication and academia in general. https://cassyni-user-files-prod.s3.amazonaws.com/XfFB6vAxTvzHMR1AdEzMUz https://cassyni.com/slides/outline/8yKijStex6ja1aK71GP1sB https://cassyni.com/events/8yKijStex6ja1aK71GP1sB/abstract https://cassyni-user-files-prod.s3.amazonaws.com/LMADXN6qDdn7P4bHyjdQ62 https://cassyni.com/events/8yKijStex6ja1aK71GP1sB?videoPreview=1 Vasculitisnohttps://cassyni.com/events/8yKijStex6ja1aK71GP1sB?videoPreview=12025-01-22T09:00:00+00:009967.52Imperial College Renal and Transplant CentreVasculitis encompasses a heterogeneous group of multi-system diseases characterized by inflammation of blood vessel walls, leading to vessel damage, occlusion, ischemia, and organ-specific manifestations depending on vessel size and location. The clinical spectrum includes primary and secondary forms, with classification often based on vessel size (large, medium, small) and serology, notably ANCA-associated vasculitis (AAV). Diagnosis integrates clinical suspicion, serological testing—favoring antigen-specific assays for proteinase-3 (PR3) and myeloperoxidase (MPO) ANCAs—imaging, and histopathology, with renal biopsy remaining the diagnostic gold standard, especially in pauci-immune glomerulonephritis. Approximately 8% of biopsy-proven AAV cases are ANCA-negative, often presenting with renal-limited disease and worse outcomes due to diagnostic delays. Differential diagnosis must consider mimics such as infections (e.g., bacterial endocarditis, tuberculosis), malignancies, drug-induced vasculitis, and age-related immune changes. Treatment guidelines from EULAR, KDIGO, and ACR recommend stratification by disease severity: organ- or life-threatening disease warrants induction with cyclophosphamide or rituximab plus glucocorticoids, with plasma exchange reserved for selected severe cases. Pulsed intravenous cyclophosphamide is preferred in Europe due to lower cumulative toxicity. Rituximab is non-inferior to cyclophosphamide for remission induction but lacks robust data in severe renal impairment. Combination regimens of low-dose cyclophosphamide and rituximab show promising remission rates and reduced relapse. Steroid-sparing strategies, including reduced-dose glucocorticoids and the C5a receptor antagonist avacopan, demonstrate efficacy with fewer adverse events and improved renal recovery. Plasma exchange reduces end-stage kidney disease risk in patients with severe renal dysfunction but increases infection risk. Non-ANCA vasculitides such as anti-GBM disease and polyarteritis nodosa exhibit distinct pathophysiology and management challenges; anti-GBM disease requires plasma exchange, cyclophosphamide, and steroids, with emerging therapies like Imlifidase showing promise in antibody clearance. Cryoglobulinaemic vasculitis, often associated with B-cell dyscrasias or infections, necessitates careful immunosuppressive therapy balancing efficacy and infection risk. Multidisciplinary collaboration and comprehensive assessment remain essential for optimizing diagnosis, prognostication, and individualized treatment in vasculitis.https://cassyni-user-files-prod.s3.amazonaws.com/LMADXN6qDdn7P4bHyjdQ62 https://cassyni.com/events/RmPtRKQPH2VQWP17AqeknR/seminar/qa https://cassyni.com/slides/outline/RmPtRKQPH2VQWP17AqeknR https://cassyni.com/events/RmPtRKQPH2VQWP17AqeknR/abstract https://cassyni-user-files-prod.s3.amazonaws.com/9AN7BEqaFjHq8auVmDHRoL https://cassyni.com/events/RmPtRKQPH2VQWP17AqeknR?videoPreview=1 #Discreetshipping: Selling E-cigarettes on TikToknohttps://cassyni.com/events/RmPtRKQPH2VQWP17AqeknR?videoPreview=12026-05-21T18:00:00+00:003024.16Center for Cancer TrainingIntroduction: Youth and young adult use of e-cigarette products continues to remain high despite regulatory approaches to reduce youth access. This study sought to examine TikTok content regarding the sale and distribution of e-cigarettes. Methods: TikTok videos (n=475) and metadata posted between June 2022 and August 2023 were scraped using a TikTok application programming interface (API) and popular hashtags used to sell vaping products (i.e., #discreetshipping [40.8 million], #puffbundle [14.8 million], #hiddennic [1.0 million]). After watching the 25 most viewed videos (39,600-868,800 views), a codebook was developed. All metadata were annotated using 11 unique codes: small business, brand, cannabis, bundled, hidden, fake, international sales, no ID, order via Instagram, order via another method, and cost. Results: Overall, 367 videos (with an average of 2,017 likes) were deemed relevant. Videos advertised popular vaping brands (50.4%) that included cannabis products (45%). Products were described as bundled (28.6%), hidden (8.7%), and able to be shipped internationally (6%) without age verification (45.2%). Some videos (8.2%) evaded algorithms' detection of illegal activity by describing the post as ‘Fake’. Customers were directed to other social media platforms (most often Instagram, 57.5%) and/or other websites/links (58.3%) to purchase products; 22.1% advertised discounts, free shipping, or low costs (ranging from 25-35 dollars). Conclusions: Social media platforms, such as TikTok and Instagram, are being used to circumvent e-cigarette regulatory policies. Regulatory agencies should expand enforcement strategies to include social media platforms where users are illegally selling and distributing e-cigarettes internationally to young audiences. https://cassyni-user-files-prod.s3.amazonaws.com/9AN7BEqaFjHq8auVmDHRoL https://cassyni.com/events/9xFqLdVBbKoN8G2VGDpioP/seminar/qa https://cassyni.com/slides/outline/9xFqLdVBbKoN8G2VGDpioP https://cassyni.com/events/9xFqLdVBbKoN8G2VGDpioP/abstract https://cassyni-user-files-prod.s3.amazonaws.com/6da1oBtCZ6NVNEFKRdfrY6 https://cassyni.com/events/9xFqLdVBbKoN8G2VGDpioP?videoPreview=1 JWPE 3-Minute Pitch – “My Life in Water” - Winner presentationsnohttps://cassyni.com/events/9xFqLdVBbKoN8G2VGDpioP?videoPreview=12026-01-30T11:00:00+00:004245.32ElsevierWe are thrilled to announce the winners of the 2025 JWPE 3-Minute pitch "My Life in Water" event, a global initiative dedicated to celebrating outstanding PhD research in water processing and engineering. This initiative aimed to support emerging researchers by providing a platform within the Journal of Water Process Engineering for them to showcase their work. Participants faced the challenge of distilling their research into a compelling three-minute presentation, using language accessible to a non-specialist audience. We have asked our winners to each deliver a short presentation on their projects to give them the opportunity to elaborate during this webinar. Congratulations to all our winners: 1st place: Yasmina Alseksek, Khalifa University of Science and Technology for her presentation on Photocatalytic membranes for emerging contaminants removal and degradation. Joint 2nd place: Olga El Kik, IMT Mines Alès & Institut Européen des Membranes for her presentation on Biology + electricity = the ultimate treatment; and Ebrahim Alosta, Khalifa University of Science and Technology for his presentation on Synthesis of hybrid nanocomposites for sustainable photocatalytic applications. 3rd place: Rajashree Yalamanchili, University of Girona for her presentation on Advancing safe water through efficient reuse and low-energy desalination.https://cassyni-user-files-prod.s3.amazonaws.com/6da1oBtCZ6NVNEFKRdfrY6 https://cassyni.com/slides/outline/DQo4fR1rfXg19xL3utCgLD https://cassyni.com/events/DQo4fR1rfXg19xL3utCgLD/abstract https://cassyni-user-files-prod.s3.amazonaws.com/TGpiNDexwn1XEVCBxmE8eS https://cassyni.com/events/DQo4fR1rfXg19xL3utCgLD?videoPreview=1 Real-time control of turbulent flow systems with reinforcement learningnohttps://cassyni.com/events/DQo4fR1rfXg19xL3utCgLD?videoPreview=12026-01-15T09:00:00+00:003186.92The Edinburgh Fluid Dynamics Group (EFDG)*[NOTE: the slides are not visible for the first five minutes of the talk! Audio was captured correctly for the whole duration of the talk.]* Reinforcement learning (RL) is increasingly used to discover control strategies for complex physical systems, yet turbulent flows remain a challenge: the dynamics are high-dimensional and nonlinear, sensing is sparse and noisy, high-fidelity simulations are computationally intractable, and experiments are expensive. In this talk, I will present recent work aimed at making RL practical for real-world flow control by combining sample-efficient learning with physics-aware representations of partially observable dynamics inherent to realistic sensor configurations.https://cassyni-user-files-prod.s3.amazonaws.com/TGpiNDexwn1XEVCBxmE8eS https://cassyni.com/events/LpYkUJEcekuZo1YvAKzrNq/seminar/qa https://cassyni.com/slides/outline/LpYkUJEcekuZo1YvAKzrNq https://cassyni.com/events/LpYkUJEcekuZo1YvAKzrNq/abstract https://cassyni-user-files-prod.s3.amazonaws.com/LFZ7aQBCWotfvruhapubYa https://cassyni.com/events/LpYkUJEcekuZo1YvAKzrNq?videoPreview=1 Patterns and Structure in the Fury and Noise: Coherent Structures and Organized Dynamics in Modern Power and Propulsion Systemsnohttps://cassyni.com/events/LpYkUJEcekuZo1YvAKzrNq?videoPreview=12026-04-14T17:00:00+00:003400.52AIAA JournalFuture propulsion and power systems will be profoundly shaped by societal drivers including decarbonization, national security, and resilience. Addressing these challenges also motivates a rich set of fundamental problems in fluid mechanics and combustion. The internal flows of aircraft engines and power plants, for example, exhibit fascinating and beautiful instabilities—phenomena that are scientifically compelling in their own right. This talk will discuss the mechanisms leading to self-organized behaviors in these systems. It will span from fundamentals to current applications and unsolved problems at the intersection of combustion, fluid mechanics, and flow stability, offering insights for industry, researchers, and students alike. https://cassyni-user-files-prod.s3.amazonaws.com/LFZ7aQBCWotfvruhapubYa https://cassyni.com/slides/outline/CRVra3ioncZrVCW3oujMXK https://cassyni.com/events/CRVra3ioncZrVCW3oujMXK/abstract https://cassyni-user-files-prod.s3.amazonaws.com/F7etkvLUE51ebpJa4NMmwc https://cassyni.com/events/CRVra3ioncZrVCW3oujMXK?videoPreview=1 Session 4A: Redox Thermochemical nohttps://cassyni.com/events/CRVra3ioncZrVCW3oujMXK?videoPreview=12025-10-21T23:30:00+00:006480.6Centre for Energy TechnologyRedox thermochemical processes are explored for their potential in cost-effective hydrogen production and high-temperature industrial heat supply, addressing global decarbonization challenges. For water splitting, two-step redox cycles operating above 1000 °C, such as those involving ceria (CeO2), face material stability and handling complexities. Alternatively, multi-step cycles using non-toxic, earth-abundant materials like manganese oxide and sodium carbonate (Mn3O4/Na2CO3) enable operation at lower temperatures, with continuous cycling demonstrated at approximately 850 °C for thermal reduction. Innovations in these systems include material development (e.g., ceria-ferrite composites) and advanced system designs that integrate reactor trains, regenerative heat transfer, and efficient oxygen removal (e.g., electrochemical/thermochemical pumps), with modeling indicating potential solar-to-fuel efficiency improvements from 10% to nearly 40%. In thermochemical energy storage, magnesium-manganese oxide systems store renewable electricity as high-temperature heat, delivering up to 1450 °C for industrial applications. This approach achieves fast charging (within 4 hours), high energy density (~2400 MJ/m³), and a 95% round-trip heat efficiency, demonstrating stability over 1000 cycles. Overall, thermal energy storage is critical for enabling continuous, 24/7 operation and reducing costs by leveraging less expensive heat sources. These processes are significant for producing hydrogen and for the synthesis of liquid fuels like syngas and methanol from water and captured carbon dioxide, contributing to broader decarbonization efforts.https://cassyni-user-files-prod.s3.amazonaws.com/F7etkvLUE51ebpJa4NMmwc https://cassyni.com/events/PHnmhiUEr3g49x2Ui1uV6m/seminar/qa https://cassyni.com/slides/outline/PHnmhiUEr3g49x2Ui1uV6m https://cassyni.com/events/PHnmhiUEr3g49x2Ui1uV6m/abstract https://cassyni-user-files-prod.s3.amazonaws.com/DTcueaaAXxYgN1XQKAiyfk https://cassyni.com/events/PHnmhiUEr3g49x2Ui1uV6m?videoPreview=1 Fusing mechanistic networks and machine learning to control heart growthnohttps://cassyni.com/events/PHnmhiUEr3g49x2Ui1uV6m?videoPreview=12026-01-30T18:00:00+00:003616.0School of Data ScienceWhile the growth of the heart (hypertrophy) aids normal development and adaptation to exercise, paradoxically it is also a leading contributor to the progression of heart failure. This paradox persists because cardiac hypertrophy is controlled by complex, only partially characterized networks of signaling and gene regulation, and because these networks have largely been studied by reductionist rather than systems-level approaches. In this presentation, I'll discuss our methods that combine mechanistic network modeling with machine learning to systematically develop and expand computational models of the heart’s regulatory networks, enabling new understanding and opportunities to target drugs against heart disease. **Sponsor**: This seminar is sponsored by the Network and Graph Data Science Research Interest Group.https://cassyni-user-files-prod.s3.amazonaws.com/DTcueaaAXxYgN1XQKAiyfk https://cassyni.com/slides/outline/RGPBtT4LbstpFfJi4ymRXK https://cassyni.com/events/RGPBtT4LbstpFfJi4ymRXK/abstract https://cassyni-user-files-prod.s3.amazonaws.com/3NjbW11LkzqpqVRbDG9QPx https://cassyni.com/events/RGPBtT4LbstpFfJi4ymRXK?videoPreview=1 Plants of South Africa for human health: successes, prospects and challenges nohttps://cassyni.com/events/RGPBtT4LbstpFfJi4ymRXK?videoPreview=12025-08-05T10:00:00+00:001959.64NoneIndigenous plants play a significant role as medicines for a large fraction of the South African population and this is linked to a strong sociocultural tradition of using plants for medical purposes. A wide range of ‘omics tools has been useful in studying different taxa in our environment. Species such as *Mesembryanthemum syn*. *Sceletium tortuosum* (Aizoaceae); *Lessertia* syn. *Sutherlandia frutescens* (Fabaceae) and *Dodonaea viscosa* (Sapindaceae) have been central to our research activities where we use both non-targeted and targeted metabolomics to understand the influence of different environments on plant metabolism. Proteomic analyses under stressed conditions provided new insights into the impacts of salinity and drought stress with respect to both central and specialized metabolism. The medicinal flora of South Africa still largely remains poorly characterized despite its potential in drug discovery pipelines. The nexus of plant biodiversity and the South African bioeconomy is governed by legislation that aims to ensure fair and equitable beneficiation of the indigenous knowledge holders. Partnerships that have been established to meet current policy are also discussed as part of this presentation. https://cassyni-user-files-prod.s3.amazonaws.com/3NjbW11LkzqpqVRbDG9QPx https://cassyni.com/events/8ULeKD4VgK4Rr1jmhN5kZ3/seminar/qa https://cassyni.com/slides/outline/8ULeKD4VgK4Rr1jmhN5kZ3 https://cassyni.com/events/8ULeKD4VgK4Rr1jmhN5kZ3/abstract https://cassyni-user-files-prod.s3.amazonaws.com/EL5v3T9PMTK5QvVnxvwR4r https://cassyni.com/events/8ULeKD4VgK4Rr1jmhN5kZ3?videoPreview=1 Arguing about morphemesnohttps://cassyni.com/events/8ULeKD4VgK4Rr1jmhN5kZ3?videoPreview=12026-04-24T01:00:00+00:003039.16Linguistics and Applied Language StudiesA problem for word-formation studies is that the notion of a word is not well defined, and this has implications for questions of productivity in word-formation. One particular problem is whether words can be created by syntactic rules as well as by rules of word-formation. In this paper, two such types are considered: sequences of adjective and noun, as in blackbird and also in red squirrel, which seem to require distinct analyses, and types like lady-in-waiting and wannabe where words exploit a wider range of syntactic structures. It is argued that the difference between a word and a syntactic structure is a matter of usage rather than a matter of grammar, largely, but not entirely, determined by how fixed the expression is in common practice.https://cassyni-user-files-prod.s3.amazonaws.com/EL5v3T9PMTK5QvVnxvwR4r https://cassyni.com/events/LKvmYF6ycfHEwiiRrTeVk9/abstract https://cassyni-user-files-prod.s3.amazonaws.com/VdZhzXUbYhFKWNa1rF7H7L https://cassyni.com/slides/outline/KqFYNvwZmqoR8Fiv4MXXZw https://cassyni.com/events/KqFYNvwZmqoR8Fiv4MXXZw/abstract https://cassyni-user-files-prod.s3.amazonaws.com/79z8xP9Z6668Zj5YzCHTBc https://cassyni.com/events/KqFYNvwZmqoR8Fiv4MXXZw?videoPreview=1 Preparing for AI Integration in Clinical Educationnohttps://cassyni.com/events/KqFYNvwZmqoR8Fiv4MXXZw?videoPreview=12026-01-15T14:00:00+00:003638.36AAMCObjectives: - Describe the potential impact of AI on clinical practice and diagnostic reasoning including risk of deskilling, never skilling, and mis-skilling. - Explore AI applications for clinical care and strategies for their use in clinical education including strategies to assess readiness and evaluate outcomes. - Highlight ethical and practical considerations for the physician-patient and human-computer relationships. - Identify how teachers can incorporate adaptive learning skills and reflective practice to support thoughtful and safe expansion of AI in clinical practice. This webinar is part of the AI Skill Building for Medical Educators Webinar Series, hosted by the AAMC. For more information, see [the complete series webpage](https://www.aamc.org/learn-network/affinity-groups/group-educational-affairs/webinar-series-ai-skill-building-medical-educators).   CME Information - View the last page of the slide deck for complete instructions on earning CME credit for this recording - CME credit for this learning opportunity is organized by Michigan State University College of Human Medicine Office of Continuing Medical Education - You will be prompted to create an account to obtain credithttps://cassyni-user-files-prod.s3.amazonaws.com/79z8xP9Z6668Zj5YzCHTBc https://cassyni.com/events/BSFthwTXiRK4kxYQSsMTR7/abstract https://cassyni-user-files-prod.s3.amazonaws.com/W7dEdzJWXaMCkxgjiommEW https://cassyni.com/events/9Th6dqPKMx2QDV4MhHZnsP/seminar/qa https://cassyni.com/slides/outline/9Th6dqPKMx2QDV4MhHZnsP https://cassyni.com/events/9Th6dqPKMx2QDV4MhHZnsP/abstract https://cassyni-user-files-prod.s3.amazonaws.com/2QoLHkp97ZzvzbYGaVjCXQ https://cassyni.com/events/9Th6dqPKMx2QDV4MhHZnsP?videoPreview=1 Bio-based nanostructures for lightweight, multifunctional materials and interfacesnohttps://cassyni.com/events/9Th6dqPKMx2QDV4MhHZnsP?videoPreview=12026-05-06T13:00:00+00:003259.4Department of AeronauticsAdvanced material systems increasingly require lightweight components with integrated functionality, where performance is often governed by interactions at interfaces. At the nanoscale, these interactions become dominant, offering opportunities to tailor material behavior through the design of nanoscale building blocks. In this context, bio-based nanostructures provide a versatile platform for controlling structure and functionality in a sustainable manner. In this talk, nanocellulose and lignin nanoparticles are presented as complementary systems with distinct structural and surface characteristics. High aspect ratio nanocellulose enables the formation of percolating networks, while lignin nanoparticles provide surface-active, intrinsically functional colloidal systems with properties such as UV absorption, antioxidant activity, and antimicrobial behavior. By tuning features such as morphology, size, and surface characteristics, these materials can be engineered to control particle–particle and particle–environment interactions, which in turn govern their macroscopic behavior. This perspective emphasizes the role of nanoscale structure and interactions in defining material functionality and highlights bio-based nanostructures as promising building blocks for lightweight, multifunctional materials and interface-dominated systems.https://cassyni-user-files-prod.s3.amazonaws.com/2QoLHkp97ZzvzbYGaVjCXQ https://cassyni.com/events/Bvxjyt8pxbifQRaPQUuvjP/seminar/qa https://cassyni.com/slides/outline/Bvxjyt8pxbifQRaPQUuvjP https://cassyni.com/events/Bvxjyt8pxbifQRaPQUuvjP/abstract https://cassyni-user-files-prod.s3.amazonaws.com/UytGa1q162oZiwtLatPez2 https://cassyni.com/events/Bvxjyt8pxbifQRaPQUuvjP?videoPreview=1 Spintronics to Neuromorphic Computingnohttps://cassyni.com/events/Bvxjyt8pxbifQRaPQUuvjP?videoPreview=12026-07-09T07:00:00+00:004944.04Advanced Physics Research JournalSpintronics has opened many avenues in condensed matter, revolutionized the data storage industry and holds rich prospects for future proof computing. The canonical Magnetic Tunnel junction not only offers new physics in magnetism and condensed matter but was the first non-volatile memory device to be integrated, commercially, in existing CMOS architecture. An important bottleneck in today’s von Neumann based computing architecture, based on digital bits, is the ‘memory wall’. This is related to the non-colocation of such memory devices with the processing units, leading to latency, large energy consumption and heat dissipation. These critical challenges can be efficiently tackled by processing the information on the signal, similar to what the human brain does. This has spurred the development of alternative, domain-specific computing paradigms beyond the conventional von-Neumann architecture, using analogue devices. The central component of such future proof computing schemes are memristors, different from the digital bits, defining a continuum of analogue states, and collocating memory and processing in the same functional unit. I will talk about my journey from Spintronics to neuromorphic computing using magnetic materials and devices and discuss the need for their implementation for upcoming computing architectures. https://cassyni-user-files-prod.s3.amazonaws.com/UytGa1q162oZiwtLatPez2 https://cassyni.com/events/CRdy9CJEoRCVDtZuCb2tub/seminar/qa https://cassyni.com/events/CRdy9CJEoRCVDtZuCb2tub/abstract https://cassyni-user-files-prod.s3.amazonaws.com/F4UAS4Rc9uF5c2K8LxTnvi https://cassyni.com/slides/outline/WCsEMHXazTRqem245TURFT https://cassyni.com/events/WCsEMHXazTRqem245TURFT/abstract https://cassyni-user-files-prod.s3.amazonaws.com/82gJvekBsDeHbfVNnTvSSi https://cassyni.com/events/WCsEMHXazTRqem245TURFT?videoPreview=1 MultiPsych Launch & Call for Papersnohttps://cassyni.com/events/WCsEMHXazTRqem245TURFT?videoPreview=12026-02-26T12:00:00+00:0082.2MultiPsych JournalThe Editor-in-Chief Dr Charlie O'Brien (she/her) will introduce MultiPsych, Wiley's brand new gold open access, author friendly, sound science journal dedicated to advancing research and scholarly dialogue across the fields of psychology, psychiatry and neuroscience. The talk will cover the scope and vision of the journal, and invite you to join our multidisciplinary community, submit your research, and to engage in dialogue with collaborators across the globe.https://cassyni-user-files-prod.s3.amazonaws.com/82gJvekBsDeHbfVNnTvSSi https://cassyni.com/slides/outline/3XrbrNbFHjXQSv2RgtNkpu https://cassyni.com/events/3XrbrNbFHjXQSv2RgtNkpu/abstract https://cassyni-user-files-prod.s3.amazonaws.com/YMYonW4EYPEEe16r3x4ne2 https://cassyni.com/events/3XrbrNbFHjXQSv2RgtNkpu?videoPreview=1 Nano TransMed Youth Forum 2025, Session IInohttps://cassyni.com/events/3XrbrNbFHjXQSv2RgtNkpu?videoPreview=12025-08-12T18:00:00+00:005591.52None[Nano TransMed (NTM)](https://www.keaipublishing.com/en/journals/nano-transmed/) is an open access peer-reviewed journal. To promote cross-boundary research and linkage between nanotechnology and clinical applications, as well as to build an inclusive, barrier-free communication platform for emerging talent in the community, NTM brings together young scholars across the field to share real-time cutting-edge technologies and the latest research findings. 2025 Session II was held on Aug. 13, 2025. Two speakers shared their latest research.https://cassyni-user-files-prod.s3.amazonaws.com/YMYonW4EYPEEe16r3x4ne2 https://cassyni.com/events/Ft4i1TmNGBNGLbGEfEwUy3/abstract https://cassyni-user-files-prod.s3.amazonaws.com/F9r64ytDc9MFFRGAdX7m74 https://cassyni.com/slides/outline/AwafYdJ7sbqEwVYtemEVEu https://cassyni.com/events/AwafYdJ7sbqEwVYtemEVEu/abstract https://cassyni-user-files-prod.s3.amazonaws.com/NWrQTQxtawXHQM7XmnATtr https://cassyni.com/events/AwafYdJ7sbqEwVYtemEVEu?videoPreview=1 Ethicality: An AI Guardrail for Research Integrity (Lightning Talks)nohttps://cassyni.com/events/AwafYdJ7sbqEwVYtemEVEu?videoPreview=12026-02-24T13:00:00+00:00419.24Researcher to ReaderEthicality is a one-stop-shop AI toolset that embeds ethical guardrails into the academic publishing workflow. By detecting misconduct signals at submission and keeping humans in the loop, it shifts publishers from reactive investigation to proactive prevention, strengthening research integrity, editorial efficiency, and trust at scale.https://cassyni-user-files-prod.s3.amazonaws.com/NWrQTQxtawXHQM7XmnATtr https://cassyni.com/events/HrgkJpsMRNWkanEsJmjs2D/abstract https://cassyni-user-files-prod.s3.amazonaws.com/6y6v89yzmGFhou7ZBfejQS https://cassyni.com/slides/outline/Uix3Ks6u5ShE744tvJyYy3 https://cassyni.com/events/Uix3Ks6u5ShE744tvJyYy3/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Ch29r6YicJeS5y1y3SitnA https://cassyni.com/events/Uix3Ks6u5ShE744tvJyYy3?videoPreview=1 H1 – AI for Research Analytics: Chatting with Institutional Data and Topic – Based Reporting at Scalenohttps://cassyni.com/events/Uix3Ks6u5ShE744tvJyYy3?videoPreview=12026-04-21T12:30:00+00:002780.04Research Analytics SummitUniversity research offices are under constant pressure to deliver fast, accurate insights—whether answering ad hoc questions about proposals, awards, and expenditures or producing topic – based rollups and trend analyses for institutional leadership. Many of these requests still require hours of manual effort across multiple systems, limiting scalability and consistency. In this session, we will demonstrate how two complementary AI – driven approaches can transform access to institutional research data through natural language interaction. First, we will explore how a robust, well – structured research data environment enables conversational analytics. Attendees will see how users can “chat” with a live research data warehouse—asking plain – English questions about proposals, awards, and expenditures—and receive immediate, trustworthy results. The system translates natural language into SQL, runs queries against live data, and returns results that can be explored, refined through follow – up questions, or exported for further analysis. Second, we will showcase LLM – assisted topic – based research reporting at scale. Using a working prototype from the University of Florida built with the UF NaviGator Toolkit, we will demonstrate how large language models can generate reliable, reusable reports for common leadership requests, such as awards by research area, funding by sponsor, active investigators, and time – bounded trend snapshots. We will discuss prompt and pattern design, evaluation approaches, early qualitative findings, and strategies for enabling non – technical staff to self – serve complex reporting through guided, no – code workflows. The session will walk through both sides of the innovation: Data Foundation: How a well – governed, high – quality data warehouse makes AI – driven reporting possible AI Integration: How modern LLMs can translate user intent into actionable queries, support conversational refinement, and maintain security and accuracy with live institutional data Through live demonstrations and discussion, attendees will leave with practical blueprints, reusable prompt patterns, and a roadmap for piloting conversational and topic – based AI reporting—whether starting from an existing data warehouse or exploring new ways to expand access and insight across the research enterprise.https://cassyni-user-files-prod.s3.amazonaws.com/Ch29r6YicJeS5y1y3SitnA https://cassyni.com/events/XCC4ZHLXGjTiTzYTTztBgy/abstract https://cassyni-user-files-prod.s3.amazonaws.com/PLUXxM48w3P9GEuXrHnxHU https://cassyni.com/slides/outline/PnVcyf9Y6E5eo7UchnrdBs https://cassyni.com/events/PnVcyf9Y6E5eo7UchnrdBs/abstract https://cassyni-user-files-prod.s3.amazonaws.com/WwwWN2z2ew9XbTSiBTrp4E https://cassyni.com/events/PnVcyf9Y6E5eo7UchnrdBs?videoPreview=1 AI in heavily regulated industries, delivering a transformation agendanohttps://cassyni.com/events/PnVcyf9Y6E5eo7UchnrdBs?videoPreview=12026-03-27T09:00:00+00:002919.4Business SchoolThis talk explores how the banking sector is navigating a heavily regulated landscape to lead a digital transformation utilising artificial intelligence. This session dives into the dual impact of AI: revolutionising the customer experience across digital channels and radically accelerating the software development lifecycle through enhanced engineering processes. Delving into how modern financial institutions balance high-speed innovation with the rigorous compliance standards required to build the future of banking.https://cassyni-user-files-prod.s3.amazonaws.com/WwwWN2z2ew9XbTSiBTrp4E https://cassyni.com/slides/outline/VDdGVBGJvGB3vX4QiR6X9F https://cassyni.com/events/VDdGVBGJvGB3vX4QiR6X9F/abstract https://cassyni-user-files-prod.s3.amazonaws.com/PFVQL7TasYCENsKoa6zkQ6 https://cassyni.com/events/VDdGVBGJvGB3vX4QiR6X9F?videoPreview=1 A free-swimming robotic platform based on the California sea lion, and its digital twinnohttps://cassyni.com/events/VDdGVBGJvGB3vX4QiR6X9F?videoPreview=12026-04-23T18:00:00+00:003996.4AI Institute in Dynamic SystemsCalifornia sea lions (Zalophus californianus) are highly maneuverable swimmers, capable of generating high thrust and agile turns. Their main propulsive surfaces, the foreflippers, feature multiple degrees of freedom, allowing their use for thrust production, turning, stability and station holding. They are agile swimmers, and highly capable terrestrial locomotors. Through field studies, followed by laboratory studies of isolated flippers to optimize propulsive forces and the simultaneous development of a 6 degree of freedom numerical model, a bio-robotic sea lion is developed. We have integrated a reinforcement learning environment for design and optimization of physical traits and gaits. The robotic sea lion platform, SEAMOUR, is free swimming in open water. This enables the physical attributes and kinematics of the body and flippers to be modified and explored simultaneously and quickly. https://cassyni-user-files-prod.s3.amazonaws.com/PFVQL7TasYCENsKoa6zkQ6 https://cassyni.com/slides/outline/7V6gT6oDc7oe7mn8LKhrSq https://cassyni.com/events/7V6gT6oDc7oe7mn8LKhrSq/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Vaw8JmGrWzCxe7k4eGJDJW https://cassyni.com/events/7V6gT6oDc7oe7mn8LKhrSq?videoPreview=1 Black Entrepreneurs in the Space Economynohttps://cassyni.com/events/7V6gT6oDc7oe7mn8LKhrSq?videoPreview=12025-11-19T16:30:00+00:00871.04Center for Black Entrepreneurship, Spelman CollegeThis study addresses the critical need for equitable access to high-growth industries by examining Black entrepreneurs' participation in the space economy. Motivated by projections showing a potential decline in median Black household wealth and the global space economy's anticipated growth to $1.4 trillion by 2030, this research seeks to identify and document Black American-owned businesses contributing to federal space missions and assess their role in generational wealth building. Phase one of the project, "Black Entrepreneurs in the Space Economy," developed a methodology based on an OECD-aligned definition of the space economy, encompassing all activities that enable, support, or derive value from space. Federal spending data from USASpending.gov, GovTribe, and HigherGov, linked to specific NAICS and Product Service Codes for NASA, the U.S. Space Force, and DOD programs, was analyzed. Over 100 Black American-owned companies were identified and manually validated, establishing a verified baseline of participation. Key findings reveal a significant pattern of "adaptive participation," where numerous Black-owned firms provide mission-critical services (e.g., engineering, IT, logistics) without explicitly branding themselves as space companies. This contributes to a visibility gap, as fewer than 10 firms self-identify as dedicated space or aerospace entities, and over 75% of these are legacy or transitional, indicating a limited number of firms actively positioned for new opportunities. Structural barriers, including limited networks and capital access, were identified as influencing market entry. The study underscores the unseen contributions of Black entrepreneurs, informing future efforts to develop policy recommendations and tools to strengthen equitable access to this burgeoning sector.https://cassyni-user-files-prod.s3.amazonaws.com/Vaw8JmGrWzCxe7k4eGJDJW https://cassyni.com/slides/outline/42ZT8KGYXuw165UZgfKtv1 https://cassyni.com/events/42ZT8KGYXuw165UZgfKtv1/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Pcyc7dCECdcJdcJ8xFt9Jn https://cassyni.com/events/42ZT8KGYXuw165UZgfKtv1?videoPreview=1 When Do Koopman Methods Work? Spectra, Prediction, and Practical Limitsnohttps://cassyni.com/events/42ZT8KGYXuw165UZgfKtv1?videoPreview=12026-04-30T18:00:00+00:003940.36AI Institute in Dynamic SystemsMany problems in science and engineering boil down to learning and predicting dynamical systems from data. Koopman operator methods offer an appealing approach: they lift nonlinear dynamics into a linear framework, enabling the use of spectral tools for analysis and forecasting. In this talk, I’ll focus on a basic but often overlooked question: when do these methods actually work in practice? I’ll present recent results that connect the underlying operator theory with the behavior of widely used algorithms, such as dynamic mode decomposition (DMD) and its variants. This perspective helps explain when Koopman spectra can be reliably approximated from finite data—and when they cannot. I’ll highlight both positive and negative results. On the one hand, we obtain conditions under which spectral quantities are well-approximated and lead to accurate predictions. On the other hand, I’ll show examples where finite data fundamentally limits what can be learned, including the construction of adversarial dynamical systems that prevent learning. Building on this, I’ll discuss how errors in spectral approximation translate into forecasting error, providing insight into how model mismatch and statistical noise affect short- and long-term predictions.https://cassyni-user-files-prod.s3.amazonaws.com/Pcyc7dCECdcJdcJ8xFt9Jn https://cassyni.com/slides/outline/EQB96frZkXZRcamhhmGnbX https://cassyni.com/events/EQB96frZkXZRcamhhmGnbX/abstract https://cassyni-user-files-prod.s3.amazonaws.com/PEys9zhp2PjoRUNvgRfoW6 https://cassyni.com/events/EQB96frZkXZRcamhhmGnbX?videoPreview=1 Breakthrough research by thieme poster prize winnernohttps://cassyni.com/events/EQB96frZkXZRcamhhmGnbX?videoPreview=12026-01-23T09:00:00+00:004938.84Thieme India ChemTalksThis collection of research highlights advances in synthetic chemistry, drug discovery, and materials science. Studies detail the development of a pseudodivergent strategy for the stereo-divergent fluoro-alkynylation of gem-difluoroallenes (DFAs) with alkynyl bromides, providing access to E- and Z-trifluoromethylated enynes with high selectivity (E:>28:1; Z:6:1), and demonstrating the critical role of geminal fluorine atoms. Another work presents a one-pot, three-step organocatalytic assembly for novel spirooctahydrofuranindoles, achieving six contiguous chiral centers with >99.5% enantiomeric excess and yields up to 78%, thereby providing access to complex fluorinated scaffolds relevant to alkaloid synthesis. In drug discovery, allosteric inhibition of dengue virus NS2B-NS3 protease is investigated, revealing that epigallocatechin gallate (EGCG) binds to a "claw-like" allosteric site (IC50 1.33 µM), inducing a closed, inactive protease conformation crucial for therapeutic development. Materials research showcases a simple, one-step in-situ synthesis of silver-based nanoparticle-hydrogel composites (Ag2O nanoparticles, 10-15 nm) for environmental remediation, demonstrating efficient catalytic degradation of organic dyes and textile wastewater (within 5 minutes, reusable for 9-10 cycles), alongside antimicrobial activity. Complementary synthetic efforts include ruthenium(II)-catalyzed C–H activation of isoquinolones to generate diverse N-polyheterocycles (81 examples) with tunable fused or spirocyclized outcomes, and a metal-free, photoinduced triarylamine EDA-complex mediated radical sulfonylation-cyclization for sulfone-containing heterocycles and Z-selective vinyl sulfones. These findings collectively expand methodologies for complex molecule synthesis, target identification, and sustainable materials.https://cassyni-user-files-prod.s3.amazonaws.com/PEys9zhp2PjoRUNvgRfoW6 https://cassyni.com/events/HrprsySnSB9PKUJihT3QQV/seminar/qa https://cassyni.com/slides/outline/HrprsySnSB9PKUJihT3QQV https://cassyni.com/events/HrprsySnSB9PKUJihT3QQV/abstract https://cassyni-user-files-prod.s3.amazonaws.com/XMTUyZFSks2AsZhtqhWQv https://cassyni.com/events/HrprsySnSB9PKUJihT3QQV?videoPreview=1 Rethinking 3D Geometry Compression Through the Lens of Structural Representationnohttps://cassyni.com/events/HrprsySnSB9PKUJihT3QQV?videoPreview=12026-09-10T11:30:00+00:003677.68Journal on Image and Video ProcessingWith the rapid development of 3D applications in VR/AR, robotics, digital twins, and immersive communication, effective 3D geometry data compression has become more critical than ever. However, the inherently irregular and unstructured nature of raw 3D data poses significant technical challenges for traditional compression frameworks, which typically thrive on highly regular grids. This talk explores advanced 3D geometry representations through the lens of spatial structurization across 1D, 2D, and 3D spaces. Specifically, we will examine how mapping complex, irregular geometric structures into structured 1D sequences, 2D image grids, or regular 3D volumetric data can successfully bridge the gap between raw spatial data and highly optimized, classical compression pipelines. By rethinking data representation as a fundamental prerequisite for efficient encoding, this presentation highlights novel, robust pathways toward ultra-efficient 3D data storage, transmission, and streaming, ultimately offering fresh insights into the future of geometric data processing.https://cassyni-user-files-prod.s3.amazonaws.com/XMTUyZFSks2AsZhtqhWQv https://cassyni.com/slides/outline/6zZZrwDEn6xT2zrTvttReu https://cassyni.com/events/6zZZrwDEn6xT2zrTvttReu/abstract https://cassyni-user-files-prod.s3.amazonaws.com/XNjQW8kQ8CDqKMFKGLu3AW https://cassyni.com/slides/outline/SkQsNPYa8LLHiMs6R8jfH7 https://cassyni.com/events/SkQsNPYa8LLHiMs6R8jfH7/abstract https://cassyni-user-files-prod.s3.amazonaws.com/4S4AmrdDGb38zoekA2bG6a https://cassyni.com/events/SkQsNPYa8LLHiMs6R8jfH7?videoPreview=1 A Soft Robotic Model for Simulating Heart Valve Disease and Cardiac Interventionsnohttps://cassyni.com/events/SkQsNPYa8LLHiMs6R8jfH7?videoPreview=12026-06-01T12:00:00+00:00264.44Advanced ScienceThe heart is a dynamic, multisystem organ whose motion is dictated by a complex but organized muscular architecture. Each component is vital to its performance, with the valves being especially critical for ensuring pumping efficiency, yet they are among the most common sites of pathology. Treatment of heart disease is being delivered via minimally invasive procedures to improve patient outcomes and experience. The development of new surgical tools and procedures would greatly benefit from a stable, controllable, and biomimetic simulation platform that accurately replicates the heart’s biomechanics and hemodynamics, yet no such system exists. This work introduces a fully synthetic, soft robotic left heart simulator capable of replicating the complex motions of native heart. Its advanced fabrication process is programmable, enabling both patient- and disease-specific cardiac geometries, structures, and valves. The simulator is compatible with clinical echocardiographic imaging, enabling identification of various valvular pathologies based on clinical diagnostic criteria. Its utility is further demonstrated through the evaluation of a new soft robotic cardiac catheter with in-situ contact force sensing and feedforward, data-driven controlsystem. With controllable artificial musculature and customizable internal cardiac structures and geometry, the simulator offers a robust platform for investigating cardiac disease and assessing emerging therapeutic technologies.https://cassyni-user-files-prod.s3.amazonaws.com/4S4AmrdDGb38zoekA2bG6a https://cassyni.com/events/4XEgHdRxNjQpur3vSc4CKP/seminar/qa https://cassyni.com/slides/outline/4XEgHdRxNjQpur3vSc4CKP https://cassyni.com/events/4XEgHdRxNjQpur3vSc4CKP/abstract https://cassyni-user-files-prod.s3.amazonaws.com/5qmz88eBMNogqt5z6u5bxa https://cassyni.com/events/4XEgHdRxNjQpur3vSc4CKP?videoPreview=1 Rare-earth nitride Raman spectroscopy: Fröhlich interaction, Cation vacanciesnohttps://cassyni.com/events/4XEgHdRxNjQpur3vSc4CKP?videoPreview=12026-07-01T08:00:00+00:003386.84School of Chemical and Physical SciencesThe rare-earth nitrides form in the rock-salt structure, which shows no conventional Raman signal, but nonetheless there is a clear vibrational Raman line in the spectrum. The two presentations identify (1) a Fröhlich interaction as activating that strong LO signal and (2) a signal from the breathing-mode vibration among the six nitrogen ions surrounding cation vacancies. https://cassyni-user-files-prod.s3.amazonaws.com/5qmz88eBMNogqt5z6u5bxa https://cassyni.com/events/NJc44sEjaaGp5QZvi9oG3X/seminar/qa https://cassyni.com/slides/outline/NJc44sEjaaGp5QZvi9oG3X https://cassyni.com/events/NJc44sEjaaGp5QZvi9oG3X/abstract https://cassyni-user-files-prod.s3.amazonaws.com/BX1QfhQzewJ54kTUvLbXJn https://cassyni.com/events/NJc44sEjaaGp5QZvi9oG3X?videoPreview=1 Biomimetic Zn(II) Coordination Networks for Self-Healing and Recyclable Thermoplastic Compositesnohttps://cassyni.com/events/NJc44sEjaaGp5QZvi9oG3X?videoPreview=12026-06-17T14:50:00+00:001463.08NoneNature offers numerous examples of materials capable of autonomously repairing damage through reversible molecular interactions. Among these, Zn(II)-mediated coordination bonds found in biological systems provide an effective combination of stiffness, toughness, and damage tolerance. Inspired by these biomimetic mechanisms, dynamic Zn(II)-ligand interactions have emerged as a promising strategy for developing intrinsically self-healing polymer matrices and composite materials. Recently, Elium® acrylic resin produced by ARKEMA has attracted significant interest as a recyclable composite matrix, combining the low-viscosity processing advantages of thermosets with the recyclability and reparability of thermoplastics. Its inherent chain mobility enables welding, thermal healing, and the incorporation of dynamic chemistries to enhance material durability. This talk explores the integration of biomimetic Zn(II)-based reversible networks within a thermoplastic resin to trigger self-healing at the fibre-matrix interface, as well as the impact of these ionic interactions on healing efficiency and enhanced fibre-matrix adhesion. The compatibility between dynamic Zn(II) coordination chemistry and recyclable thermoplastic matrices is demonstrated, providing a sustainable pathway toward multifunctional composite structures with enhanced damage tolerance, extended service life, and improved circularity. https://cassyni-user-files-prod.s3.amazonaws.com/BX1QfhQzewJ54kTUvLbXJn https://cassyni.com/slides/outline/ViL7m7wcASaeZz6Pg2ezTX https://cassyni.com/events/ViL7m7wcASaeZz6Pg2ezTX/abstract https://cassyni-user-files-prod.s3.amazonaws.com/4r1Cpi2fvGwhT6csvW718i https://cassyni.com/events/ViL7m7wcASaeZz6Pg2ezTX?videoPreview=1 The upper thermal limit of photosynthetic function in 26 Eucalyptus and Corymbia species depends more on leaf size than climate-of-originnohttps://cassyni.com/events/ViL7m7wcASaeZz6Pg2ezTX?videoPreview=12026-06-02T14:30:00+00:00780.16Heatwaves have become more intense and widespread across the globe with many locations now hitting 50°C. Such close-to-lethal temperatures are a growing risk to forest health, resulting in increased tree mortality, but the upper thermal tolerance limits of many trees are currently unknown. Both temperature intensity and exposure duration contribute to a given “heat dose” resulting in heat damage accumulation at which point photosynthesis stops functioning. Here we investigated photosystem impairment in 22 *Eucalyptus* and *Corymbia* species from different climates across Australia. Using 30 duration-temperature combinations, heat stress responses were measured using chlorophyll fluorescence (FV/FM), which declines as heat stress accumulates. None of the leaves remained functional beyond 5 minutes at 56 °C, indicating a clear upper thermal limit for the *Eucalyptus* and *Corymbia* species. About half of the species coped with 30 minutes at 44 °C There was a clear relationship between heat tolerance and leaf size, but not with leaf thickness, whereas heat dose relationships did not differ with climate-of-origin. Understanding heat dose thresholds is key for predicting the likelihood of plant mortality due to increasing heat stress in a future hotter world.https://cassyni-user-files-prod.s3.amazonaws.com/4r1Cpi2fvGwhT6csvW718i https://cassyni.com/slides/outline/YBa8zYBEMjM8vvZxDiZdBT https://cassyni.com/events/YBa8zYBEMjM8vvZxDiZdBT/abstract https://cassyni-user-files-prod.s3.amazonaws.com/2NmBbHo3izBD6A9KNpCNQn https://cassyni.com/events/YBa8zYBEMjM8vvZxDiZdBT?videoPreview=1 Opening Panel discussionnohttps://cassyni.com/events/YBa8zYBEMjM8vvZxDiZdBT?videoPreview=12026-06-02T12:30:00+00:001519.44This panel discussion will establish the conceptual foundation for the New Phytologist Symposium Extreme Heat: extending the thermal limits of life by exploring how extreme heat is understood in plant science. It will integrate perspectives from microclimate modelling, empirical observations from extremely hot environments, organismal responses to spatial variability in heat exposure, and long term, place-based experience of extreme heat. The goal will be to provide a framework for later sessions that examine physiological tolerance, acclimation, adaptation, and ecosystem responses. The discussion will also explicitly link the science to the location of the meeting, recognising Córdoba and Mediterranean systems as contemporary examples of landscapes already living with recurrent extreme heat. https://cassyni-user-files-prod.s3.amazonaws.com/2NmBbHo3izBD6A9KNpCNQn https://cassyni.com/slides/outline/Qmr5JHUMms3dAtP3fYwzjP https://cassyni.com/events/Qmr5JHUMms3dAtP3fYwzjP/abstract https://cassyni-user-files-prod.s3.amazonaws.com/2sQndySaASjJm9SRtMNtxN https://cassyni.com/events/Qmr5JHUMms3dAtP3fYwzjP?videoPreview=1 Canopy temperature drivers across ecosystems and remote sensing measurement challengesnohttps://cassyni.com/events/Qmr5JHUMms3dAtP3fYwzjP?videoPreview=12026-06-05T07:40:00+00:00677.92Extreme heat is reshaping ecosystem function, with canopy temperatures often exceeding surrounding air temperatures and approaching physiological limits. First, I investigate whether canopy temperature exceeds air temperature across ecosystems. My recent work demonstrates that canopy temperature consistently exceeds or closely tracks air temperature, using long-term near-surface thermal infrared remote sensing observations across the National Ecological Observatory Network in the United States. However, the magnitude of canopy-air temperature differences varies significantly among vegetation types (e.g., grasses are hotter than deciduous forests). Vegetation types also differ in their sensitivities to the environmental drivers shaping these gradients, indicating that vegetation type provides a first-order understanding of how ecosystems experience and respond to heat extremes. These ecological insights rely on accurate canopy temperature observations across ecosystems. However, remotely sensed thermal measurements are influenced by many confounding factors, which can introduce biases. Second, I will briefly discuss remote sensing measurements uncertainties under high temperatures and strategies to improve these measurements. This includes findings from a Thermal Bakeoff workshop in Arizona that I led, which reveals that commonly used thermal cameras underestimate temperature at high temperatures. Such principles are critical for measuring extreme heat across ecosystems, whether in the field, with aircraft, or with satellites.https://cassyni-user-files-prod.s3.amazonaws.com/2sQndySaASjJm9SRtMNtxN https://cassyni.com/slides/outline/Uj69u1gL6FKrqk8kJzH6MK https://cassyni.com/events/Uj69u1gL6FKrqk8kJzH6MK/abstract https://cassyni-user-files-prod.s3.amazonaws.com/9njo1Jef7qMjDHvb8xTgQE https://cassyni.com/events/Uj69u1gL6FKrqk8kJzH6MK?videoPreview=1 Optimizing stellarator optimization: recent advances in theory and numericsnohttps://cassyni.com/events/Uj69u1gL6FKrqk8kJzH6MK?videoPreview=12026-08-06T15:00:00+00:003082.04Journal of Plasma PhysicsStellarators offer exceptional freedom in magnetic geometry, but this freedom turns reactor design into a high-dimensional optimization problem. This talk reviews recent theoretical and numerical developments that make this problem more tractable. I will discuss how confinement properties such as omnigenity, energetic-particle losses and bootstrap current can be translated into practical optimization targets; how structure-preserving orbit calculations improve the reliability of direct simulation; and how differentiation and reduced descriptions help identify the most effective directions in configuration space. Together, these developments allow us to test the limits of familiar design principles while exploring a broader range of stellarator geometries.https://cassyni-user-files-prod.s3.amazonaws.com/9njo1Jef7qMjDHvb8xTgQE https://cassyni.com/events/8y9z3foLXwBD8i8hHrkN5T/abstract https://cassyni-user-files-prod.s3.amazonaws.com/MjnHaXQXRkE5Tcsu9gPF8r https://cassyni.com/events/Po5hNsy9YoXus973hiZuSu/abstract https://cassyni-user-files-prod.s3.amazonaws.com/GP3TKkg8ed3K7gkzAuKoMp https://cassyni.com/events/EQmDVtgBD71ggcQ8hgz4rZ/abstract https://cassyni-user-files-prod.s3.amazonaws.com/4zAvKNxbC3VjCaqPwbd1Ca https://cassyni.com/slides/outline/Xi8JrvgpEndHabK1jU1RNm https://cassyni.com/events/Xi8JrvgpEndHabK1jU1RNm/abstract https://cassyni-user-files-prod.s3.amazonaws.com/GbAmzWWxQwfiEz9WXQrogz https://cassyni.com/events/XgtuqE1pWusK7TaSRcSf1F/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Rtmd7SUkREEu5Ca6XHz67g https://cassyni.com/slides/outline/2YXmeNnK1TVXdgW2JLxzPP https://cassyni.com/events/2YXmeNnK1TVXdgW2JLxzPP/abstract https://cassyni-user-files-prod.s3.amazonaws.com/3N6Ji8kyj51tuDFNPRVTYJ https://cassyni.com/events/2YXmeNnK1TVXdgW2JLxzPP?videoPreview=1 Hong Kong in a Polarized Worldnohttps://cassyni.com/events/2YXmeNnK1TVXdgW2JLxzPP?videoPreview=12024-01-27T12:00:00+00:007179.12Hong Kong Baptist UniversityA seminar addressed Hong Kong's evolving role as a "super-connector" and East-West intermediary within an increasingly polarized global landscape. Historically positioned as a gateway between China and the West, Hong Kong's distinctive institutional vibrancy under "one country, two systems" supported China's modernization and attracted international capital. However, rising US-China rivalry, geopolitical shifts, and internal events since 2019 have challenged this position, generating international doubts, as evidenced by a Moody's credit rating outlook downgrade from "stable" to "negative" and India surpassing its stock market size. Analysis indicates that while Hong Kong's governance indicators for effectiveness, regulatory quality, rule of law, and corruption control remain high, scores for voice and accountability have declined. Over-reliance on the mainland economy and passive policy approaches have reduced economic diversity and resilience, contributing to a substantial GDP per capita gap with Singapore and a manufacturing sector representing less than 1% of GDP. The study concludes that Hong Kong's exceptionalism must be actively earned through strategic reinvention. This requires diversifying economic and political connections beyond traditional East-West links to include the Global South (e.g., ASEAN, Middle East), fostering indigenous capabilities, and developing hard-to-replicate competitive advantages via proactive government industrial policies. Critical self-reflection, a clear long-term strategic plan, and an environment supporting robust, evidence-based dialogue about China and Hong Kong's challenges are deemed essential for navigating the complex multipolar world and securing its unique value.https://cassyni-user-files-prod.s3.amazonaws.com/3N6Ji8kyj51tuDFNPRVTYJ https://cassyni.com/slides/outline/24JWK8s5cQqLAAEn3AURYH https://cassyni.com/events/24JWK8s5cQqLAAEn3AURYH/abstract https://cassyni-user-files-prod.s3.amazonaws.com/2V8tabj94p3rt4io4pE1Wv https://cassyni.com/events/24JWK8s5cQqLAAEn3AURYH?videoPreview=1 Passing Days, Hidden Nightsnohttps://cassyni.com/events/24JWK8s5cQqLAAEn3AURYH?videoPreview=12021-12-04T12:00:00+00:007576.88Hong Kong Baptist UniversityIn celebration of the 60th anniversary of the Faculty of Arts, 'Showcasing Six Decades of the Faculty of Arts: Look Back at the Future' was held on 4 Dec 2021 at Academic Community Hall. We were honoured to invite Prof. Rick Wong, Interim Provost of the HKBU, as well as Prof. Mette Hjort, Dean of Arts of the HKBU, as the officiating guests to kick start the Showcase. Both online and live audiences applauded the teachers and students for their superb performances.https://cassyni-user-files-prod.s3.amazonaws.com/2V8tabj94p3rt4io4pE1Wv https://cassyni.com/slides/outline/4XYXYZ6hohbpX6iLarP4GD https://cassyni.com/events/4XYXYZ6hohbpX6iLarP4GD/abstract https://cassyni-user-files-prod.s3.amazonaws.com/NBDgGpUzc6zaGg6bcfthkA https://cassyni.com/events/4XYXYZ6hohbpX6iLarP4GD?videoPreview=1 The Worlds Within a Singularity (Part 2)nohttps://cassyni.com/events/4XYXYZ6hohbpX6iLarP4GD?videoPreview=12022-05-24T12:00:00+00:002699.84Hong Kong Baptist UniversityThe project *The Once and Future* is an expanded cinema experience exploring themes of time, human civilization's voyages, and humanity's relationship with its planet within a speculative science fiction framework of potential planetary exodus. It navigates the past to inform future possibilities, moving beyond a singular hero narrative to reflect collective human experience. The film integrates a central character, the Minotaur (Niu Mó Wáng), a hybrid figure rooted in both Western and Asian folklore, representing a recurring artistic motif. Presented as a live event, the work challenges conventional cinematic and theatrical engagement by deploying three concurrent film screens, creating a "cubist" effect that offers multiple perspectives on scenes and aims to defragment realities. High-precision lasers act as a live narrator, representing a singular consciousness (from uploaded human minds), interacting dynamically with projected imagery and creating physical light structures. A live performer contributes vocals in an improvisational Hindustani style, embodying a physical musical presence. This multi-sensory approach aims to create an active, embodied audience experience, contrasting with passive screen viewing. A related module, *Project Labyrinth*, serves as an interactive digital prequel, utilizing online technologies to further engage audiences with the underlying premise of climate confrontation and humanity's future.https://cassyni-user-files-prod.s3.amazonaws.com/NBDgGpUzc6zaGg6bcfthkA https://cassyni.com/events/BwGbEooaPZuf1gEoYjEngD/abstract https://cassyni-user-files-prod.s3.amazonaws.com/LJ2SWv4kEP4BgemcRuDNNA https://cassyni.com/events/BwGbEooaPZuf1gEoYjEngD?videoPreview=1 The Mystery and the Magic of Electionsnohttps://cassyni.com/events/BwGbEooaPZuf1gEoYjEngD?videoPreview=12021-05-01T12:00:00+00:003205.56Hong Kong Baptist UniversityA scholar in the fields of media and politics, Professor Cherian George assesses the changing role of the media in Singapore’s general elections, analyses the various campaign styles of the parties, and raises some questions voters should be asking.https://cassyni-user-files-prod.s3.amazonaws.com/LJ2SWv4kEP4BgemcRuDNNA https://cassyni.com/slides/outline/CvZoLB6dGV1ogS4oehi7V7 https://cassyni.com/events/CvZoLB6dGV1ogS4oehi7V7/abstract https://cassyni-user-files-prod.s3.amazonaws.com/H5SurxwWVjvJL8NRt8iziS https://cassyni.com/events/CvZoLB6dGV1ogS4oehi7V7?videoPreview=1 Style and Aesthetics of Film Directing and Film Production Review of 'We Are Hong Kongers'nohttps://cassyni.com/events/CvZoLB6dGV1ogS4oehi7V7?videoPreview=12022-07-09T12:00:00+00:00245.84Hong Kong Baptist UniversityThis reflective study reviews the style and aesthetics of film directing and production for the creative work, 'We Are Hong Kongers,' a short film released in May 2022. The film's primary message is to foster public and professional understanding of the challenges faced by the South Asian elderly community in Hong Kong, aiming to facilitate improved health and social care services and reduce disparities through broadcast media. Script development involved over one year of research, including interviews and documentary work with the South Asian elderly in Hong Kong, which identified learning Cantonese as their most significant challenge. Production faced three main obstacles: writing an authentic script that voiced the real views of this community; enabling South Asian actors to deliver Cantonese dialogue naturally; and conducting shooting during the COVID-19 pandemic. These were overcome by extensive script research, translating the Chinese script into English and Hindi versions, streamlining complex dialogue, and implementing rigorous hygienic precautions, insurance, and site disinfection during filming. The project offers insights into cinematic approaches for raising social awareness and navigating practical production complexities in a cross-cultural context.https://cassyni-user-files-prod.s3.amazonaws.com/H5SurxwWVjvJL8NRt8iziS https://cassyni.com/slides/outline/FPopZbLFTmnJ3NYNCPckD3 https://cassyni.com/events/FPopZbLFTmnJ3NYNCPckD3/abstract https://cassyni-user-files-prod.s3.amazonaws.com/B9Sgm3mveqNSPJCys6BxZ4 https://cassyni.com/events/FPopZbLFTmnJ3NYNCPckD3?videoPreview=1 People, communities, and the Catholic Church in Chinanohttps://cassyni.com/events/FPopZbLFTmnJ3NYNCPckD3?videoPreview=12020-01-01T12:00:00+00:003117.0Hong Kong Baptist UniversityThis event explores the Chinese Catholic Church as a whole as well as focusing on particular aspects of its activities, including diplomacy, politics, leadership, pilgrimage, youths, and non-Chinese Catholics in China. It discusses Sino-Vatican relations and the rationale behind the decisions taken by Pope Francis with regard to the appointment of bishops in China. It discusses Sino-Vatican relations and the rationale behind the decisions taken by Pope Francis with regard to the appointment of bishops in China. It also examines important changes and personalities in the Chinese Church, the Catholic organizations, and the Catholic communities in the Church.https://cassyni-user-files-prod.s3.amazonaws.com/B9Sgm3mveqNSPJCys6BxZ4 https://cassyni.com/slides/outline/NJTwVifJZmeBLiW5KUVifF https://cassyni.com/events/NJTwVifJZmeBLiW5KUVifF/abstract https://cassyni-user-files-prod.s3.amazonaws.com/EWAPwZQTJX5GVdTqoNK8bG https://cassyni.com/events/NJTwVifJZmeBLiW5KUVifF?videoPreview=1 HK Artist Spotlight Seriesnohttps://cassyni.com/events/NJTwVifJZmeBLiW5KUVifF?videoPreview=12021-06-29T12:00:00+00:00196.24Hong Kong Baptist UniversityThe artistic practice of Wai Bong Koon explores the complexities of multiple cultures, integrating Chinese aesthetic traditions with Western art influences, particularly through the medium of ink painting. While drawn to the ethereal elegance of bamboo, Koon's work transcends a mere reflection of nature, serving instead as a vehicle to transport viewers into a personal mindscape. A central aspect of this approach involves blurring the boundaries of conventional ink painting, exemplified by the transformation of bamboo forest paintings into large-scale installation works. One notable instance involved a 5-meter-high installation, allowing viewers to physically walk through and experience the forest closely. This immersive strategy aimed to teleport individuals from reality into the artist's mental vision, both physically and psychologically. The creative process is viewed as a means of discovering alternative perspectives on the world. Reflecting on contemporary challenges, such as those posed by COVID-19, Koon highlights a shift towards virtual exhibitions and boundaryless art, enabled by digital platforms. It is suggested that enhanced collaboration between arts organizations—including museums, art fairs, and galleries—and local artists is crucial for supporting the artistic community and showcasing their work publicly in challenging times and beyond.https://cassyni-user-files-prod.s3.amazonaws.com/EWAPwZQTJX5GVdTqoNK8bG https://cassyni.com/slides/outline/No7YYQJq1ECELV2xuunWvZ https://cassyni.com/events/No7YYQJq1ECELV2xuunWvZ/abstract https://cassyni-user-files-prod.s3.amazonaws.com/2ws66FFHa6KQtRy1tv8Vwk https://cassyni.com/events/No7YYQJq1ECELV2xuunWvZ?videoPreview=1 Jason Eng Hun Lee reads 'What They Saw' by Melody Geenohttps://cassyni.com/events/No7YYQJq1ECELV2xuunWvZ?videoPreview=12021-09-20T12:00:00+00:00122.68Hong Kong Baptist UniversityNo abstracthttps://cassyni-user-files-prod.s3.amazonaws.com/2ws66FFHa6KQtRy1tv8Vwk https://cassyni.com/slides/outline/HMyu2tC4BC79wcnjJzniw7 https://cassyni.com/events/HMyu2tC4BC79wcnjJzniw7/abstract https://cassyni-user-files-prod.s3.amazonaws.com/8trrmCFiuGBwfAVXw8zXQ https://cassyni.com/events/HMyu2tC4BC79wcnjJzniw7?videoPreview=1 The interpreter's mindnohttps://cassyni.com/events/HMyu2tC4BC79wcnjJzniw7?videoPreview=12021-11-25T12:00:00+00:001894.64Hong Kong Baptist UniversityMinhua Liu discusses the cognitive intricacies of simultaneous interpreting.https://cassyni-user-files-prod.s3.amazonaws.com/8trrmCFiuGBwfAVXw8zXQ https://cassyni.com/slides/outline/ViC1ByNB9dx1qJ2YHMMT5F https://cassyni.com/events/ViC1ByNB9dx1qJ2YHMMT5F/abstract https://cassyni-user-files-prod.s3.amazonaws.com/G98nPCo89fJC5jYAWgQfFt https://cassyni.com/events/ViC1ByNB9dx1qJ2YHMMT5F?videoPreview=1 Hong Kong Media Freedom Post-NSLnohttps://cassyni.com/events/ViC1ByNB9dx1qJ2YHMMT5F?videoPreview=12021-06-21T12:00:00+00:007398.76Hong Kong Baptist UniversityJune 30 marks the first anniversary of Beijing’s promulgation of Hong Kong’s new national security law. While containing assurances that human rights and press freedom would be protected, the NSL amounted to the single most significant shift in the territory’s legal order since its return to China, and heralded a year of unprecedented incursions into Hong Kong’s media freedoms. Our roundtable of academic experts will attempt to make sense of the tectonic shifts in Hong Kong’s media environment, placing the tumultuous events of recent months in a broader political and global context, and contemplating how journalists and their publics might adapt to — and shape — the emerging media and communication terrain.https://cassyni-user-files-prod.s3.amazonaws.com/G98nPCo89fJC5jYAWgQfFt https://cassyni.com/slides/outline/YBS2RPboLviWCEW6q3G5oB https://cassyni.com/events/YBS2RPboLviWCEW6q3G5oB/abstract https://cassyni-user-files-prod.s3.amazonaws.com/V8rspYxiEwL3DM5FAhqDNE https://cassyni.com/events/YBS2RPboLviWCEW6q3G5oB?videoPreview=1 Platformisation, Surveillance, and Affective Relations in the Hong Kong Independent Music Scenenohttps://cassyni.com/events/YBS2RPboLviWCEW6q3G5oB?videoPreview=12023-05-05T12:00:00+00:00751.64Hong Kong Baptist UniversityThis presentation combines three studies on the post-2019 Hong Kong underground music scene to illustrate the ways that the scene has utilised social media as a method of survival during the COVID-19 pandemic. Due to bans on public performances of music and other social distancing laws, members of the scene have used social media platforms to perform music virtually. This platformisation has catalysed explorations into the use of creative locations and has foregrounded the visual dimension of live music performance and the ways that Hong Kong is visually represented by these musicians, reasserting a new ‘local’ in the international gaze of social media. Social media platforms have also been used to facilitate the move of the scene to the underground by allowing information of gigs to be disseminated and for tickets to be sold virtually out of the gaze of authorities. This need for anonymity is contrasted with the Taiwan scene that does not need to hide in the shadows of social media platforms, and highlights the self-imposed discipline of the Hong Kong scene as a result of the authoritarian gaze of the government that the scene perceives as a threat to its survival. Social media platforms thus facilitate the physical gig, where affective alliances are engendered through feelings of mutual precarity and exclusivity that envelopes the whole process. The Hong Kong scene is thus an example of how the virtual is as much a space as the physical, where socialities, performativity and resistance occurs in conjunction with the physical. This inseparability of the virtual and physical challenges the methodologies used for each respectively, where both need to be considered in equal terms to understand the socialities at play in the post-2019 Hong Kong underground music scene.https://cassyni-user-files-prod.s3.amazonaws.com/V8rspYxiEwL3DM5FAhqDNE https://cassyni.com/slides/outline/Qmhxj8tvm4QzSCKCGseTM7 https://cassyni.com/events/Qmhxj8tvm4QzSCKCGseTM7/abstract https://cassyni-user-files-prod.s3.amazonaws.com/QtNAK8p5yi9XzMAqRvmadc https://cassyni.com/events/Qmhxj8tvm4QzSCKCGseTM7?videoPreview=1 Balancing Innovation & Integrity: Developing Ethical Guidelines for AI Use in Educationnohttps://cassyni.com/events/Qmhxj8tvm4QzSCKCGseTM7?videoPreview=12025-09-26T12:00:00+00:002907.28Hong Kong Baptist UniversityThis seminar addresses the ethical challenges and opportunities posed by artificial intelligence (AI) in education, emphasizing the need to balance innovation with integrity. It situates AI within a broad spectrum of applications—from virtual assistants and AI-generated media to accessibility tools and data analysis—highlighting the complexity of ethical considerations. The discussion introduces a theoretical framework grounded in a moral vision centered on wellbeing at personal, societal, and planetary levels, supported by virtues such as honesty, humility, creativity, and integrity. Key concerns include epistemic risks like AI hallucinations, bias replication, intellectual deskilling, and the opaque “black-box” nature of AI systems, alongside issues of data privacy, environmental impact, and unequal access. The analysis critiques common responses—such as outright rejection or uncritical adoption of AI—advocating instead for nuanced approaches that incorporate AI literacy, collaborative use, and inclusive design principles. Emphasizing collective responsibility, the seminar proposes ethical guidelines that foreground solidarity, justice, and sustainability, urging educators to consider AI’s lifecycle impacts and to involve communities in decision-making. Practical strategies include fostering character development, assessing learning processes over outputs, and drafting concise institutional AI policies that articulate positive commitments to digital ethics and wellbeing. This integrative approach aims to equip educational stakeholders to navigate AI’s tragic dilemmas thoughtfully, promoting equitable and responsible AI integration in diverse educational contexts.https://cassyni-user-files-prod.s3.amazonaws.com/QtNAK8p5yi9XzMAqRvmadc https://cassyni.com/slides/outline/TEwyxZ8YxMBUo8nkpZZ653 https://cassyni.com/events/TEwyxZ8YxMBUo8nkpZZ653/abstract https://cassyni-user-files-prod.s3.amazonaws.com/HZWSskVE86WtqcQhX7c41U https://cassyni.com/events/TEwyxZ8YxMBUo8nkpZZ653?videoPreview=1 Relieving Broadway: The Politics of Traffic in Nineteenth-Century New York Citynohttps://cassyni.com/events/TEwyxZ8YxMBUo8nkpZZ653?videoPreview=12023-04-27T12:00:00+00:002870.76Hong Kong Baptist UniversityHistorians usually date the origins of traffic control in the U.S. to the early twentieth century, but in nineteenth-century Manhattan, managing movement through the city streets was a major political project. This paper examines efforts across the nineteenth century to “relieve” Broadway, New York’s principal thoroughfare, of its congestion. The solutions that New Yorkers proposed, including street openings, traffic police, and urban railways, reflected divergent ideas about whose movement should be privileged and whose should be curtailed. The question of how to relieve Broadway was thus also a question about how to manage the city’s growth and how to govern a diverse population. As Broadway’s traffic intensified in the nineteenth century, control of mobility emerged as a principal field of political conflict and government action.https://cassyni-user-files-prod.s3.amazonaws.com/HZWSskVE86WtqcQhX7c41U https://cassyni.com/slides/outline/7yfR9tu5qVac2YkFuFxnNq https://cassyni.com/events/7yfR9tu5qVac2YkFuFxnNq/abstract https://cassyni-user-files-prod.s3.amazonaws.com/5MBvasuE5vQcMS5KvFcryL https://cassyni.com/events/7yfR9tu5qVac2YkFuFxnNq?videoPreview=1 Three Ecologies in Hong Kong Independent Documentariesnohttps://cassyni.com/events/7yfR9tu5qVac2YkFuFxnNq?videoPreview=12020-12-03T12:00:00+00:001401.52Hong Kong Baptist UniversityThe Preservation Movement of Star Ferry and Queen’s Piers, an influential social movement happened from 2006–2007, widely affected the public’s understanding of space from regarded it as a piece of resources for development and exploitation to re-discerned it as a place with memory and history, a place for daily leisure activities, and a place for making new relationships. Since 2006, a series of space-related social movements had happened in the city, including The Anti-Lee Tung Street Redevelopment Project Movement and The Anti-Hong Kong Express Rail Link and Preserving Choi Yuen Village Movement, from which one can witness the changing understanding of space. Over the last decade and a half, Hong Kong independent documentary filmmakers attempt to articulate new human-space relationships in their productions. This paper argues that this new understanding of human-space relationship enables the filmmakers to envision in their films the three ecologies, i.e. the ecology of urban space, of agricultural land, and of rural communities. By analyzing Lam Sam’s Queen’s Pier and Lo Chun-yip’s Days After n Coming, this paper argues that how the polluted idea of space based on the believes of neo-liberalism is redefined through the intimate engagement between human subjects and the space/place (the ecology of urban space). Through the examination of Raging Land Trilogy as well as Chan Ho-lun’s agricultural documentaries, this paper attempts to show how the new understanding of space later leads the activists to rethink the production of space through habitation and the reproduction of land through farming. In these documentaries, one can see how land is intricately linked to neo-liberalist capitalism, the Chinese nation-building project, and the political network of the establishment. Finally, by exploring Ma Chi-hang’s Ballad on the Shore and Chan Ho-lun and Chloe Lai’s Rhymes of Shui Hau, this paper contends that these two ethnographic documentaries conjure up the ecology of rural communities through the records of songs and sounds, manifesting how human lives, the rural environments on which they live, the changing nature, and the culture of lyrics and songs are interconnected with each other.https://cassyni-user-files-prod.s3.amazonaws.com/5MBvasuE5vQcMS5KvFcryL https://cassyni.com/slides/outline/33BNh4RqSv3adT2utnFneh https://cassyni.com/events/33BNh4RqSv3adT2utnFneh/abstract https://cassyni-user-files-prod.s3.amazonaws.com/CnnhwK8UexnBKTDoAADRta https://cassyni.com/events/33BNh4RqSv3adT2utnFneh?videoPreview=1 From Netflix to iQiyi: As the World Turns, Serial Dramas in Virtual Circulationnohttps://cassyni.com/events/33BNh4RqSv3adT2utnFneh?videoPreview=12023-11-29T12:00:00+00:003867.92Hong Kong Baptist UniversityThis talk discusses the interplay between serial dramas and streaming services in PRC and the US, the two leading countries in content-production and circulation in the era of non-linear, non-synchronized, and subscription-based online consumption characterized by “binge” in an instantaneous and globalized streaming ecosystem.https://cassyni-user-files-prod.s3.amazonaws.com/CnnhwK8UexnBKTDoAADRta https://cassyni.com/events/62DXeySKbTM1Nbo2H6bSuK/seminar/qa https://cassyni.com/slides/outline/62DXeySKbTM1Nbo2H6bSuK https://cassyni.com/events/62DXeySKbTM1Nbo2H6bSuK/abstract https://cassyni-user-files-prod.s3.amazonaws.com/8GuHE3U3fon8XffhAuGuci https://cassyni.com/events/62DXeySKbTM1Nbo2H6bSuK?videoPreview=1 Shock Capturing For High-Order Nodal Spectral Element Methodsnohttps://cassyni.com/events/62DXeySKbTM1Nbo2H6bSuK?videoPreview=12021-04-22T14:00:00+00:003318.08PyFRThe presence of discontinuities in nonlinear hyperbolic conservation laws is a long-standing challenge in the development of high-order numerical methods. In this talk, I will present an approach to shock capturing for discontinuous spectral element methods which uses invariant domain preservation techniques to construct a low-order scheme devoid of tunable parameters. This technique is then enhanced using a novel point-local entropy residual indicator that is independent of grid spacing and polynomial order, which enables the scheme to recover high-order accuracy in smooth regions and sub-element resolution of discontinuous solutions even at very high orders. The effectiveness of this method is then shown in several numerical test cases that include shock tubes, complex explosion problems, and aeronautical applications.https://cassyni-user-files-prod.s3.amazonaws.com/8GuHE3U3fon8XffhAuGuci https://cassyni.com/events/FuBcaeNpNcRLE7o3nfMp3F/abstract https://cassyni-user-files-prod.s3.amazonaws.com/AYp7Rqa8T2QBLRYx8QoAK8 https://cassyni.com/events/15jVC8y5CsoyyW5gGctTBB/abstract https://cassyni-user-files-prod.s3.amazonaws.com/9SMW5JNCTk9utysj4rFFJn https://cassyni.com/events/15jVC8y5CsoyyW5gGctTBB?videoPreview=1 From playing with artificial muscles to selling motion capture gloves, the StretchSense journeynohttps://cassyni.com/events/15jVC8y5CsoyyW5gGctTBB?videoPreview=12021-03-30T03:00:00+00:003505.08The Auckland Bioengineering InstituteDr Ben O’Brien joined the ABI in 2007 as part of Professor Iain Anderson’s Biomimetics Lab, where he also met fellow PhD student (now Dr) Todd Gisby and they had an unreasonable amount of fun making things out of artificial muscles. In 2012 the three co-founded StretchSense to bring an entirely new type of stretchable sensor to market. Today, StretchSense is the clear market leader for stretchable motion capture gloves for the gaming and animation industry. Ben will talk about the winding journey from there to here as well as the challenges and successes along the way and the experiences bringing deep tech products to market. Ben will bring a live demo of our MocapPro Supersplay glove and software Hand Engine, which are awesome. The talk will start as a presentation but will hopefully degenerate into a conversation, or even better, a debate. https://cassyni-user-files-prod.s3.amazonaws.com/9SMW5JNCTk9utysj4rFFJn https://cassyni.com/slides/outline/DS45okCjnmMhnAviRyvYnh https://cassyni.com/events/DS45okCjnmMhnAviRyvYnh/abstract https://cassyni-user-files-prod.s3.amazonaws.com/KFjuqgEUGcdWncSuAaJ7Dx https://cassyni.com/events/DS45okCjnmMhnAviRyvYnh?videoPreview=1 Responsive Mechanical Metamaterials for Unprecedent Wave Control and Odd Elasticitynohttps://cassyni.com/events/DS45okCjnmMhnAviRyvYnh?videoPreview=12022-02-08T14:00:00+00:005983.72MetaMATBiological and artificial machinery systems have utilized the approach made by sensing, actuating, and information processing to adapt themselves to environmental changes, maintain dynamic equilibrium, and execute particular functions. In this talk, we present how to leverage this approach to construct active and responsive mechanical metamaterials for enabling a range of unprecedent wave phenomena and mechanical properties. The active mechanical metamaterials are composed of piezoelectric sensors and actuators connected with digital electronic circuits. The electrical circuits implemented allow for precisely and independently modulating mechanical properties of the metamaterial through programmable transfer functions. By developing active theory, numerical simulations and conducting experimental testing, we systematically demonstrate their application in broadband wave mitigation, independently wave transmission and reflection control, non-local dynamics, wave mode conversion and odd micropolar elasticity for realizing non-Hermitian mechanics and dynamics.https://cassyni-user-files-prod.s3.amazonaws.com/KFjuqgEUGcdWncSuAaJ7Dx https://cassyni.com/slides/outline/LqomcdRVmzbGRE9agRiiqK https://cassyni.com/events/LqomcdRVmzbGRE9agRiiqK/abstract https://cassyni-user-files-prod.s3.amazonaws.com/cWknwForfKkYSZJxJyhRY https://cassyni.com/events/LqomcdRVmzbGRE9agRiiqK?videoPreview=1 Wave propagation in gyro-elastic microstructured medianohttps://cassyni.com/events/LqomcdRVmzbGRE9agRiiqK?videoPreview=12022-01-18T14:00:00+00:004937.16MetaMATIn this talk, wave propagation in gyro-elastic structured media are presented. The system is a lattice composed of periodically placed masses interconnected by elastic rods and attached to gyroscopic spinners. The analysis is based on an asymptotic model that describes the interaction between a gyroscopic spinner and a mass embedded in a truss system. Several examples are given that illustrate the transient features of special dynamic phenomena, including unidirectional interfacial waves and highly localised waveforms. In the second part of the talk Rayleigh waves are analysed in elastic lattices incorporating gyroscopic effects. The vector problems of elasticity for a triangular lattice and its long-wavelength/low-frequency continuum approximation are considered. The analytical procedure gives explicit solutions for the Rayleigh waves for both the discrete and continuous systems. Despite the symmetry of the dispersion curves with respect to the wavenumber, the introduction of the inertial coupling breaks the symmetry of the eigenmodes and makes the system non- reciprocal.https://cassyni-user-files-prod.s3.amazonaws.com/cWknwForfKkYSZJxJyhRY https://cassyni.com/slides/outline/WEYbD4SmA71SU94jt5GvBF https://cassyni.com/events/WEYbD4SmA71SU94jt5GvBF/abstract https://cassyni-user-files-prod.s3.amazonaws.com/4qAWfB8UYWAPHYahTqi1sc https://cassyni.com/events/WEYbD4SmA71SU94jt5GvBF?videoPreview=1 The macroecology of Mesozoic dinosaursnohttps://cassyni.com/events/WEYbD4SmA71SU94jt5GvBF?videoPreview=12024-11-22T12:00:00+00:001398.84Royal Society PublishingDinosaurs thrived for over 160 million years in Mesozoic ecosystems, displaying diverse ecological and evolutionary adaptations. Their ecology was shaped by large-scale climatic and biogeographic changes, calling for a ‘deep-time’ macroecological investigation. These factors include temperature fluctuations and the break up of Pangaea, influencing species richness, ecological diversity and biogeographic history. Recent improvements in the dinosaur fossil record have enabled large-scale studies of their responses to tectonic, geographic and climatic shifts. Trends in species diversity, body size and reproductive traits can now be analysed using quantitative approaches like phylogenetic comparative methods, machine learning and Bayesian inference. These patterns sometimes align with, but also deviate from, first-order macroecological rules (e.g. species–area relationship, latitudinal biodiversity gradient, Bergmann’s rule). Accurate reconstructions of palaeobiodiversity and niche partitioning require ongoing taxonomic revisions and detailed anatomical descriptions. Interdisciplinary research combining sedimentology, geochemistry and palaeoclimatology helps uncover the environmental conditions driving dinosaur adaptations. Fieldwork in under-sampled regions, particularly at latitudinal extremes, is crucial for understanding the spatial heterogeneity of dinosaur ecosystems across the planet. Open science initiatives and online databases play a key role in advancing this field, enriching our understanding of deep-time ecological processes, and offering new insights into dinosaur macroecology and its broader implications.https://cassyni-user-files-prod.s3.amazonaws.com/4qAWfB8UYWAPHYahTqi1sc https://cassyni.com/slides/outline/6WtkpHbjSGpqC4nY5CiR5X https://cassyni.com/events/6WtkpHbjSGpqC4nY5CiR5X/abstract https://cassyni-user-files-prod.s3.amazonaws.com/AbvU5zA4i64bQM21J6iThG https://cassyni.com/events/6WtkpHbjSGpqC4nY5CiR5X?videoPreview=1 Learning Nonlinear Operators using Deep Neural Networks for Diverse Applicationsnohttps://cassyni.com/events/6WtkpHbjSGpqC4nY5CiR5X?videoPreview=12021-10-04T14:00:00+00:003238.44Journal of Computational PhysicsThe universal approximation theorem of operators is suggestive of the potential of NNs in learning from scattered data any continuous operator or complex system. We first generalize the theorem to deep neural networks, and subsequently we apply it to design a new composite NN with small generalization error, the deep operator network (DeepONet), consisting of a NN for encoding the discrete input function space (branch net) and another NN for encoding the domain of the output functions (trunk net). We demonstrate that DeepONet can learn various explicit operators, e.g., integrals, Laplace transforms and fractional Laplacians, as well as implicit operators that represent deterministic and stochastic differential equations. More generally, DeepOnet can learn multiscale operators spanning across many scales and trained by diverse sources of data simultaneously. We will demonstrate the effectiveness of DeepOnet to Multiphysics and multiscale problems and compare against other operator regression networks such as the Fourier Neural Operator (FNO), which is limited to simple domains.https://cassyni-user-files-prod.s3.amazonaws.com/AbvU5zA4i64bQM21J6iThG https://cassyni.com/slides/outline/HPEvBDNwJRnrZqPPq6WbPb https://cassyni.com/events/HPEvBDNwJRnrZqPPq6WbPb/abstract https://cassyni-user-files-prod.s3.amazonaws.com/HkgBm7xeCLRQ2FWoJkkYFG https://cassyni.com/events/HPEvBDNwJRnrZqPPq6WbPb?videoPreview=1 Multistable inflatable origami – from deployable structures to robotsnohttps://cassyni.com/events/HPEvBDNwJRnrZqPPq6WbPb?videoPreview=12021-06-15T14:00:00+00:003731.52MetaMATMultistable structures can reversibly change between multiple stable configurations when a sufficient energetic input is provided. While originally the field focused on understanding what governs the snapping, more recently it has been shown that these systems also provide a powerful platform to design a wide range of smart structures. In this talk, I will first show that pressure-deployable origami structures characterized by two stable configurations provide opportunities for a new generation of large-scale inflatable structures that lock in place after deployment and provide a robust enclosure through their rigid faces. Then, I will demonstrate that the bistable origami modules provide an ideal platform to design actuators that can switch between different configurations, reach multiple, pre-defined targets in space, and move along complex trajectories. Unlike previously proposed robots that require complex input control of multiple actuators, a single input signal suffices to activate our robot, as all features required for functionality are embedded into the architecture of the building blocks.https://cassyni-user-files-prod.s3.amazonaws.com/HkgBm7xeCLRQ2FWoJkkYFG https://cassyni.com/events/5XenxBLTN5a3U8QjfzwrCV/abstract https://cassyni-user-files-prod.s3.amazonaws.com/RRTD7UHJEwcPgqWNFp4cu4 https://cassyni.com/slides/outline/3Z7czhn8QyD758d6Cz6dHP https://cassyni.com/events/3Z7czhn8QyD758d6Cz6dHP/abstract https://cassyni-user-files-prod.s3.amazonaws.com/8cSdHc297ANN2qXa4tdstS https://cassyni.com/events/3Z7czhn8QyD758d6Cz6dHP?videoPreview=1 Fixity and English compoundsnohttps://cassyni.com/events/3Z7czhn8QyD758d6Cz6dHP?videoPreview=12022-10-14T03:00:00+00:003381.08Linguistics and Applied Language StudiesWe all know that English ‘has’ ‘compounds’, so why don’t we know what counts as a compound in English? Could we have been asking the wrong question? One of the striking things about English word-formation is how productive compounds are. Yet definitions of a compound in English are extremely varied, and tests for whether or not something is a compound give very different results. It is suggested that the reason for this is that the so-called tests for compoundhood are really tests for something else – here called ‘fixity’. If we accept that, we may not need a category of ‘compound’ in English at all.https://cassyni-user-files-prod.s3.amazonaws.com/8cSdHc297ANN2qXa4tdstS https://cassyni.com/slides/outline/4YMarp3QVATtoNaja2UXPb https://cassyni.com/events/4YMarp3QVATtoNaja2UXPb/abstract https://cassyni-user-files-prod.s3.amazonaws.com/CSU4PuHTWTfVQFfULcvnrS https://cassyni.com/events/4YMarp3QVATtoNaja2UXPb?videoPreview=1 What are English Language Institute teachers working on in their language programmes?nohttps://cassyni.com/events/4YMarp3QVATtoNaja2UXPb?videoPreview=12021-06-18T16:00:00+00:003717.88Linguistics and Applied Language StudiesThe English Language Institute (ELI) offers a diverse range of English language programmes for academic or professional purposes, as well as pre-service teacher education courses. In this presentation, ELI teachers will talk briefly about what they are working on in their programme to promote better learning or teaching.https://cassyni-user-files-prod.s3.amazonaws.com/CSU4PuHTWTfVQFfULcvnrS https://cassyni.com/slides/outline/SmXmwaA2EmPMbtPuYZ9zMK https://cassyni.com/events/SmXmwaA2EmPMbtPuYZ9zMK/abstract https://cassyni-user-files-prod.s3.amazonaws.com/CUqHfuoKfys1pa5VUHwkAz https://cassyni.com/events/SmXmwaA2EmPMbtPuYZ9zMK?videoPreview=1 2D Navier-Stokes equations on a bounded domain with holes and Navier friction boundary conditionsnohttps://cassyni.com/events/SmXmwaA2EmPMbtPuYZ9zMK?videoPreview=12021-10-28T13:00:00+00:003453.0Partial Differential Equations and ApplicationsWe will discuss the large time behavior of solutions of 2D Navier-Stokes in bounded domains which are not necessarily simply connected, when we impose Navier friction boundary conditions. We establish exponential time decay, for both velocity and vorticity, under various assumptions on the friction coefficient relative to curvature of the boundary, for different types of domains. We also discuss the special role, played by the disk and the annulus, in this analysis. This is joint work with Christophe Lacave, Milton Lopes Filho and Jim Kelliher. https://cassyni-user-files-prod.s3.amazonaws.com/CUqHfuoKfys1pa5VUHwkAz https://cassyni.com/slides/outline/VjT2LJZ4GsdiTWdCoT5KXj https://cassyni.com/events/VjT2LJZ4GsdiTWdCoT5KXj/abstract https://cassyni-user-files-prod.s3.amazonaws.com/KrS1D2Td4XmrofnFPPfWLn https://cassyni.com/events/VjT2LJZ4GsdiTWdCoT5KXj?videoPreview=1 Phason Engineering for Topological Wave Steeringnohttps://cassyni.com/events/VjT2LJZ4GsdiTWdCoT5KXj?videoPreview=12021-01-26T14:00:00+00:007259.16MetaMATA general principle discovered by Jean Bellissard says that every aperiodic pattern has an intrinsic global degree of freedom that lives on a topological space called the hull of a pattern. This concept generalizes the notion of phason found in the physics literature on quasicrystals. In this talk, I will describe various ways to characterize and compute the hull of quasi-periodic patterns (i.e. aperiodic perturbations of periodic lattices) and then I will turn to problem of generating patterns with prescribed hulls, a process that I call phason engineering. Specifically, I will describe the main philosophy and supply a very general algorithm that produces phason spaces that are d-tori with d arbitrarily large. If discrete resonators are placed according to such a pattern, I will show that the hull augments the physical space, hence opening a door to the physic of the Integer Quantum Hall Effect in arbitrary dimensions. In the second part, I will demonstrate laboratory implementations of the ideas with mechanical and acoustic metamaterials that exhibit 2D and 4D IQHE physics. Among these examples, is the first un-assisted dynamical edge-to-edge Thouless pumping achieved in a laboratory.https://cassyni-user-files-prod.s3.amazonaws.com/KrS1D2Td4XmrofnFPPfWLn https://cassyni.com/slides/outline/FQcssrGx9EeNKeQmBZiDLR https://cassyni.com/events/FQcssrGx9EeNKeQmBZiDLR/abstract https://cassyni-user-files-prod.s3.amazonaws.com/6vV13HThaLGrCHEzLwa64N https://cassyni.com/events/FQcssrGx9EeNKeQmBZiDLR?videoPreview=1 Understanding soliton dynamics in Boussinesq modelsnohttps://cassyni.com/events/FQcssrGx9EeNKeQmBZiDLR?videoPreview=12020-09-21T15:00:00+00:002823.68Partial Differential Equations and ApplicationsThe purpose of this talk is to describe in simple terms the soliton problem for several Boussinesq models, including good, improved and abcd systems. The problem is not simple, because some particular unstable behavior present in each system above mentioned. The idea is to explain the particularities of each system, previous and recent results, and future research, in simple words.https://cassyni-user-files-prod.s3.amazonaws.com/6vV13HThaLGrCHEzLwa64N https://cassyni.com/slides/outline/YCh3ZingUAQCpT6mM8yxFf https://cassyni.com/events/YCh3ZingUAQCpT6mM8yxFf/abstract https://cassyni-user-files-prod.s3.amazonaws.com/F32VfUMbaEc3nvDNkXcegW https://cassyni.com/events/YCh3ZingUAQCpT6mM8yxFf?videoPreview=1 Elastic metasurfacesnohttps://cassyni.com/events/YCh3ZingUAQCpT6mM8yxFf?videoPreview=12020-07-21T14:00:00+00:003282.48MetaMATElastic waves guided along surfaces dominate applications in geophysics, ultrasonic inspection, mechanical vibration, and surface acoustic wave devices; precise manipulation of surface Rayleigh waves and their coupling with polarized body waves presents a challenge that offers to unlock the flexibility in wave transport required for efficient energy harvesting and vibration mitigation devices. In this talk I will describe various designs of elastic metasurfaces, based around a graded array of rod resonators attached to an elastic substrate that, together with critical insight from Umklapp scattering in phonon-electron systems, allow us to leverage the transfer of crystal momentum; we mode-convert Rayleigh surface waves into bulk waves that form tunable beams. Experiments, theory and simulation verify that these tailored Umklapp mechanisms play a key role in coupling surface Rayleigh waves to reversed bulk shear and compressional waves independently, thereby creating passive self-phased arrays allowing for tunable redirection and wave focusing within the bulk medium. We have also looked recently at piezoelectric coupling and the use of these devices in energy harvesting and, if time allows, I will discuss this too.https://cassyni-user-files-prod.s3.amazonaws.com/F32VfUMbaEc3nvDNkXcegW https://cassyni.com/slides/outline/QnxysU5otJ6h4QurnyNKob https://cassyni.com/events/QnxysU5otJ6h4QurnyNKob/abstract https://cassyni-user-files-prod.s3.amazonaws.com/9GdWjiLFNLLH4y6AGR3xNr https://cassyni.com/events/QnxysU5otJ6h4QurnyNKob?videoPreview=1 On Optimal Control of Complex Dynamical Systemsnohttps://cassyni.com/events/QnxysU5otJ6h4QurnyNKob?videoPreview=12021-02-10T14:00:00+00:002661.64Department of AeronauticsNowadays, achieving efficient computations of optimal trajectories for dynamical systems represents a hard problem. In particular, the presence of nonlinearities and uncertainties affecting the outcome makes this task very challenging. With the objective of introducing optimal control strategies that address those difficulties, in this talk I will discuss two interrelated frameworks: Sequential Convex Programming (SCP) and Pullback Bundle Dynamical Systems (PBDS), from both theoretical and numerical perspectives. Specifically, I will first show how SCP can be leveraged to solve non-linear stochastic optimal control problems. Then, I will explain how efficient real-time initialization strategies can be compute by PBDS for complex dynamical systems.https://cassyni-user-files-prod.s3.amazonaws.com/9GdWjiLFNLLH4y6AGR3xNr https://cassyni.com/slides/outline/7zvSJE5xxjGJemLvRMgeqK https://cassyni.com/events/7zvSJE5xxjGJemLvRMgeqK/abstract https://cassyni-user-files-prod.s3.amazonaws.com/69Cc4BnWusbsfu41XCjFAW https://cassyni.com/events/7zvSJE5xxjGJemLvRMgeqK?videoPreview=1 Taking textbooks to task: Case studies from diverse language classroomsnohttps://cassyni.com/events/7zvSJE5xxjGJemLvRMgeqK?videoPreview=12021-11-12T03:00:00+00:003121.12Linguistics and Applied Language Studies*Are language textbooks any use? How can tasks (TBLT) help?* In this seminar, the TBLT-SIG group (Task-based Language Teaching special interest group) at LALS will introduce five ongoing TBLT research projects. All five projects are classroom-based and located in settings where mandated textbooks are used, covering Indonesia, Vietnam, New Zealand, and China. Each investigates: (1) whether and how textbook-based lessons can be rejuvenated if taught using principles from TBLT; and (2) the experience of teachers and learners in these task-based lessons and their perceptions of learning benefits. The seminar will begin with a brief overview of TBLT and the vision of the TBLT-SIG group. The group will then provide a snapshot of the research on adapting textbooks being undertaken in each project. The speakers will try and leave plenty of time for questions because we’d really appreciate your feedback. **TBLT Special Interest Group (in alphabetical order)** Phuong Cao, Hao Dao, Jonathan Newton, Yoshie Nishikawa, Priska Pramastiwi & Jing Xiyuan You can view the seminar [here](https://vstream.au.panopto.com/Panopto/Pages/Viewer.aspx?id=02426c54-c5e1-4273-afb6-adde00481bcb) https://cassyni-user-files-prod.s3.amazonaws.com/69Cc4BnWusbsfu41XCjFAW https://cassyni.com/events/34SPqPcia9jHFfdaQsyf7B/seminar/qa https://cassyni.com/slides/outline/34SPqPcia9jHFfdaQsyf7B https://cassyni.com/events/34SPqPcia9jHFfdaQsyf7B/abstract https://cassyni-user-files-prod.s3.amazonaws.com/BDjUPqiUFukfpMsg1vJPbU https://cassyni.com/events/34SPqPcia9jHFfdaQsyf7B?videoPreview=1 PyFR: Latest Developments and Future Roadmapnohttps://cassyni.com/events/34SPqPcia9jHFfdaQsyf7B?videoPreview=12022-05-23T14:00:00+00:003777.2Journal of Computational PhysicsPyFR is a high-order accurate Computational Fluid Dynamics (CFD) solver based on the Flux Reconstruction approach of Huynh. It is written in Python, and can target a range of hardware platforms via an innovative Mako-based domain specific language. Over the past decade PyFR has matured into an established part of the open source CFD ecosystem. It now has an active community of users around the world, and is routinely applied to undertake high-fidelity scale-resolving simulations across a range of application areas, including at extreme scale. This talk will present results from some of the latest simulations to be undertaken with PyFR, and provide insight into some of our latest technological developments, including cache blocking optimisations for the CPU backend, and turbulence injection approaches. Finally, I will outline our roadmap for future development of the solver.https://cassyni-user-files-prod.s3.amazonaws.com/BDjUPqiUFukfpMsg1vJPbU https://cassyni.com/events/Bx5eZ4kH52mjHx7CXuLFob/seminar/qa https://cassyni.com/slides/outline/Bx5eZ4kH52mjHx7CXuLFob https://cassyni.com/events/Bx5eZ4kH52mjHx7CXuLFob/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Uvz7cCiEaYZtBCKt8rMCpW https://cassyni.com/events/Bx5eZ4kH52mjHx7CXuLFob?videoPreview=1 Matariki Embracing a New Holiday for all New Zealandersnohttps://cassyni.com/events/Bx5eZ4kH52mjHx7CXuLFob?videoPreview=12022-05-26T00:15:00+00:003724.36The MacDiarmid Institute for Advanced Materials and NanotechnologyMatariki-Puanga has become a national holiday in Aotearoa-New Zealand and is due to start this year in 2022 during the Tangaroa nights in the month of Pipiri. This is on the Gregorian date of the 24th of June, 2022. Matariki and Puanga are stars that are an important part of a larger Māori calendar system called the maramataka, which is based on the position of the sun, stars, phases of the moon aswell as environmental and ecological indicators. The development of knowledge surrounding Matariki, Puanga and maramataka over the past 30 years has seen both Māori and non-Māori communities embrace the important times associated with these stars. The principle and values of the Matariki holiday were developed by the Matariki Advisory Committee. One of the core values of these values is Mana Taiao, Environmental Awareness. In this talk I will discuss the revitalisation of Matariki, Puanga and the maramataka, the practices and cultural understandings of Matariki and also how we as researchers can contribute to Mana Taiao to contribute to the wellbeing of Papatuanuku. https://cassyni-user-files-prod.s3.amazonaws.com/Uvz7cCiEaYZtBCKt8rMCpW https://cassyni.com/slides/outline/62MeE81kcFye7HrsfmtzHb https://cassyni.com/events/62MeE81kcFye7HrsfmtzHb/abstract https://cassyni-user-files-prod.s3.amazonaws.com/92J4M8GebmzHSSFUzRnL5c https://cassyni.com/events/62MeE81kcFye7HrsfmtzHb?videoPreview=1 Recent Developments on Intersection Searchingnohttps://cassyni.com/events/62MeE81kcFye7HrsfmtzHb?videoPreview=12022-04-12T17:50:00+00:002146.04Discrete & Computational GeometryNo abstracthttps://cassyni-user-files-prod.s3.amazonaws.com/92J4M8GebmzHSSFUzRnL5c https://cassyni.com/slides/outline/KMVrzPnQDvtXVkdBUbN4mK https://cassyni.com/events/KMVrzPnQDvtXVkdBUbN4mK/abstract https://cassyni-user-files-prod.s3.amazonaws.com/TbsqioNZvbGj9i7ZcoNZzn https://cassyni.com/events/KMVrzPnQDvtXVkdBUbN4mK?videoPreview=1 Community, Economy and COVID-19 Lessons from Multi-Country Analyses of a Global Pandemicnohttps://cassyni.com/events/KMVrzPnQDvtXVkdBUbN4mK?videoPreview=12022-11-17T17:00:00+00:005354.76Springer Nature Sustainable Development Goals ProgrammeBased on the recently published Springer book with the same title, the talk will involve a discussion by renowned well-being experts on the impact the pandemic has had on the health, safety, and socioeconomic well-being of communities around the world. The panelists will look at how community well-being has been impacted by the most significant crises of our time, the COVID-19 pandemic. Key takeaways from the discussion will be: lessons learned from the experiences in these countries and recommendations on mitigating the impact of future pandemics on the well-being of communities.https://cassyni-user-files-prod.s3.amazonaws.com/TbsqioNZvbGj9i7ZcoNZzn https://cassyni.com/slides/outline/8VbfTYFNoYk8UELSDTod1X https://cassyni.com/events/8VbfTYFNoYk8UELSDTod1X/abstract https://cassyni-user-files-prod.s3.amazonaws.com/6Fvxo5xqGCozziZnoWe8ES https://cassyni.com/events/8VbfTYFNoYk8UELSDTod1X?videoPreview=1 Internal breaking wave: from the dead water effect to complex structuresnohttps://cassyni.com/events/8VbfTYFNoYk8UELSDTod1X?videoPreview=12022-04-12T10:40:00+00:001599.04Water WavesA movement of a ship in a density stratified environment generates different internal waves systems. These waves cause boat’s slowdowns, known as dead-water. In wide channel experiments, the boat’ speed oscillates when passing a dispersive undulating depression. With strong lateral confinement (narrow channel), the amplitude of the waves increases, and the boat can even come to a stop. When the waves’ cambers become too high, breaking-waves appear at the stern. The study of this phenomenon has led us to revisit an old experiment of Scott Russell. The Scottish engineer studied the formation and propagation of dispersive waves when an object is removed from a laterally confined open channel with a shallow layer of water. The “vacuum” created by the mass removal generates a linear dispersive free surface deformation with a front of negative polarity followed by a wave train. If we extend this configuration to a two-layers stratification, we can observe a linear dispersive wave with negative polarity à la Scott Russell, propagating along the interface. During an initial disturbance of high amplitude many other structures appear. The wave front will first break, generating a mixing zone. Within this area, baroclinic modes can appear as a wave response to vertical displacements. Finally, if the amplitude of the initial impulse is even stronger, a hydraulic response appears. Indeed, a BOLUS, or breaking wave 2-mode, (an ovoid coherent mass of recirculating mixed fluids immerged in a surrounding medium/a of different density/ies) propagating along a pycnocline. These different hydraulic or wave structures have been observed experimentally by a subpixel detection method allowing spatiotemporal monitoring of structures of very low amplitudes.https://cassyni-user-files-prod.s3.amazonaws.com/6Fvxo5xqGCozziZnoWe8ES https://cassyni.com/slides/outline/15sbmHYWDgSciC9XfJBzZT https://cassyni.com/events/15sbmHYWDgSciC9XfJBzZT/abstract https://cassyni-user-files-prod.s3.amazonaws.com/CYFFcifSozsfeNghspYfMx https://cassyni.com/events/15sbmHYWDgSciC9XfJBzZT?videoPreview=1 Extending and Developing Flux Reconstruction for Polygonsnohttps://cassyni.com/events/15sbmHYWDgSciC9XfJBzZT?videoPreview=12022-07-21T14:00:00+00:003474.4PyFRIn this presentation I will present recent developments in defining flux reconstruction methods on polygons. In particular, I will show how, using summation-by-parts, how an extended range of flux reconstruction schemes can be defined on triangles, quadrilaterals, and for the first time on hexagons. This extended set can then be used to investigate stable spectral differnce schemes. Further research will be presented demonstrating how these methods can be used to define stable schemes on quadrilaterals with alternative polynomial basis. We will introduce the Euclidean order basis and show that similar numerical perofrmance can be acheived with it as with a maximal order basis, but with fewer points per element.https://cassyni-user-files-prod.s3.amazonaws.com/CYFFcifSozsfeNghspYfMx https://cassyni.com/slides/outline/FuKj9nxFPR3xxoruBLfMRX https://cassyni.com/events/FuKj9nxFPR3xxoruBLfMRX/abstract https://cassyni-user-files-prod.s3.amazonaws.com/DrxUnXJtEFRJGGkaqqbkoQ https://cassyni.com/events/FuKj9nxFPR3xxoruBLfMRX?videoPreview=1 Climate Risk Disclosures and Auditor Expertisenohttps://cassyni.com/events/FuKj9nxFPR3xxoruBLfMRX?videoPreview=12022-08-31T01:30:00+00:005408.68SACLThis paper examines whether climate risk disclosure is associated with audit partner expertise. The Task Force on Climate-Related Financial Disclosures (TCFD) has issued recommendations on how to report the financial impact of climate-related risks and the Australian Joint Bulletin (AASB & AUASB) has stated that both preparers and auditors should consider the impact of climate risks on the company’s financials. Using data on the top 500 Australian listed companies, we investigate whether climate risk disclosure practices are associated with audit partner industry expertise and expertise in climate-related issues. We define auditor expertise in climate-related issues based on their client portfolio composition in terms of 1) emissions and 2) industries with material climate risks. Our results indicate that audit partner expertise in both industry and climate-related issues is positively associated with the likelihood and quality of client climate risk disclosures, and that these findings are driven by clients operating in industries with material climate risks. Our study connecting auditing to climate-related financial disclosures is timely and should be of great importance to regulators, firms, auditors, and researchers, and those interested in the impact of climate change risks on the economy in general. Link to paper [here](https://web.tresorit.com/l/5YxnD#nEiGrGeTFQA9hf0UWbplog)https://cassyni-user-files-prod.s3.amazonaws.com/DrxUnXJtEFRJGGkaqqbkoQ https://cassyni.com/slides/outline/AUC5eGqUZNxtZwcfaRfZS5 https://cassyni.com/events/AUC5eGqUZNxtZwcfaRfZS5/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Y8jzPZ9AuAEZXGeLtShmeW https://cassyni.com/events/AUC5eGqUZNxtZwcfaRfZS5?videoPreview=1 Stomatanohttps://cassyni.com/events/AUC5eGqUZNxtZwcfaRfZS5?videoPreview=12022-05-25T15:30:00+00:005381.04New PhytologistHosted by New Phytologist Advisor, Rob Roelfsema, University of Würzburg Featuring - Maoya Bassiouni, author of [Parsimony versus predictive and functional performance of three stomatal optimization principles in a big-leaf framework](https://nph.onlinelibrary.wiley.com/doi/10.1111/nph.17392) - Xiaoyu Guo, author of [Establishing asymmetry: stomatal division and differentiation in plant](https://nph.onlinelibrary.wiley.com/doi/10.1111/nph.17613) - Silvere Vialet-Chabrand, author of [Light, power, action! Interaction of respiratory energy- and blue light-induced stomatal movements](https://nph.onlinelibrary.wiley.com/doi/10.1111/nph.17538) https://cassyni-user-files-prod.s3.amazonaws.com/Y8jzPZ9AuAEZXGeLtShmeW https://cassyni.com/slides/outline/MLUzmwaucp56Eh96UXqh1X https://cassyni.com/events/MLUzmwaucp56Eh96UXqh1X/abstract https://cassyni-user-files-prod.s3.amazonaws.com/N8YEnVDYBbLvUN6SMcfd1p https://cassyni.com/events/MLUzmwaucp56Eh96UXqh1X?videoPreview=1 Light transport in complex scattering media: practical applications in 3D graphics, Sensing and Machine Learningnohttps://cassyni.com/events/MLUzmwaucp56Eh96UXqh1X?videoPreview=12022-10-05T02:00:00+00:003538.2Computer Graphics GroupAccurate modeling of optical radiation propagation and interactions with complex materials such as biological tissues is a key ingredient in a number of practical applications from 3D photorealistic computer graphics rendering to sensing and biomedical visualization. This talk considers development of the novel algorithms and their subsequent implementations capable of dealing with multilayered translucent materials such as human skin. Firstly, we outline the detailed theoretical procedures required to solve both vector Radiative Transport and Raytracing equations simultaneously using light's orbital angular momentum beyond traditional radiometry. We created and successfully implemented a dual, unbiased Monte Carlo approach working in synergy for photon transport and path tracing techniques while executing on novel specialized NVIDIA’s Graphics Processing Units (GPUs) which support Compute Unified Device Architecture (CUDA) and Real-Time Raytracing (RTX) capabilities. Secondly, we focus on a number of practical applications such as 3D immersive demos and comprehensive examples of translucent material renderings of photorealistic quality, advanced optical sensing and biomedical visualization applications, etc. We perform a formal comparison of the developed algorithms with known analytical solutions, data obtained during in vivo clinical studies as well as previously developed offline rendering approaches. Finally, we show how recent developments in Machine Learning (ML) methods could assist with acquisition of material properties, corresponding BSSRDFs (Bidirectional scattering-surface distribution function) and aid with light transport calculations.https://cassyni-user-files-prod.s3.amazonaws.com/N8YEnVDYBbLvUN6SMcfd1p https://cassyni.com/events/HswmTA4EYcCTCzqXpsTjUh/abstract https://cassyni-user-files-prod.s3.amazonaws.com/BduNjvGYVx9RQfvFRAC2rS https://cassyni.com/slides/outline/XDT5hcXQPy9R6D97z6c49T https://cassyni.com/events/XDT5hcXQPy9R6D97z6c49T/abstract https://cassyni-user-files-prod.s3.amazonaws.com/6Efx25VknSd4Hw4Fmbr6MU https://cassyni.com/events/XDT5hcXQPy9R6D97z6c49T?videoPreview=1 Nutmeg: a MIP and CP Hybrid Solver Using Branch-and-Checknohttps://cassyni.com/events/XDT5hcXQPy9R6D97z6c49T?videoPreview=12021-02-11T15:06:00+00:00574.08Operations Research ForumNo abstracthttps://cassyni-user-files-prod.s3.amazonaws.com/6Efx25VknSd4Hw4Fmbr6MU https://cassyni.com/slides/outline/YD7PHAWyWaJ71cYndf4aiy https://cassyni.com/events/YD7PHAWyWaJ71cYndf4aiy/abstract https://cassyni-user-files-prod.s3.amazonaws.com/X7iwhD7VEEgqEeMgrWC18a https://cassyni.com/events/YD7PHAWyWaJ71cYndf4aiy?videoPreview=1 Enteropathway: the metabolic pathway database for the human gut microbiotanohttps://cassyni.com/events/YD7PHAWyWaJ71cYndf4aiy?videoPreview=12024-10-08T12:00:00+00:00294.76Microbiome Virtual International ForumThe human gut microbiota produces diverse, extensive metabolites that have the potential to affect host physiology. Despite significant efforts to identify metabolic pathways for producing these microbial metabolites, a comprehensive metabolic pathway database for the human gut microbiota is still lacking. Here, we present Enteropathway, a metabolic pathway database that integrates 3269 compounds, 3677 reactions, and 876 modules that were obtained from 1012 manually curated scientific literature. Notably, 698 modules of these modules are new entries and cannot be found in any other databases. The database is accessible from a web application (https://enteropathway.org) that offers a metabolic diagram for graphical visualization of metabolic pathways, a customization interface, and an enrichment analysis feature for highlighting enriched modules on the metabolic diagram. Overall, Enteropathway is a comprehensive reference database that can complement widely used databases, and a tool for visual and statistical analysis in human gut microbiota studies and was designed to help researchers pinpoint new insights into the complex interplay between microbiota and host metabolism.https://cassyni-user-files-prod.s3.amazonaws.com/X7iwhD7VEEgqEeMgrWC18a https://cassyni.com/events/LrE7L59npQVAcPbbxwoMJd/seminar/qa https://cassyni.com/slides/outline/LrE7L59npQVAcPbbxwoMJd https://cassyni.com/events/LrE7L59npQVAcPbbxwoMJd/abstract https://cassyni-user-files-prod.s3.amazonaws.com/GmVZGnpPyVy7q8EJhdXPkS https://cassyni.com/events/LrE7L59npQVAcPbbxwoMJd?videoPreview=1 The Universalism of Logic in Stephen Langton’s Analysis of the Blessing Given to Jacobnohttps://cassyni.com/events/LrE7L59npQVAcPbbxwoMJd?videoPreview=12024-11-27T15:00:00+00:004540.48Logica UniversalisIn this talk, I illustrate the universalism of logic using the example of Stephen Langton's (†1228) exegesis presented in his theological question 103. This text refers to the biblical story of Isaac blessing his son Jacob, who pretended to be his brother, Esau . I present the universalism of logic understood as its broad applicability and effectiveness. I argue that logic is very useful even in analyzing biblical exegesis. Langton's exegesis benefits from logical knowledge on different levels. One of them is the application of a semiotic theory to formulate a solution to the problem of the validity of Isaac's blessing. Above all, Langton distinguishes between a discrete and a vague (or simple) use of the pronoun “you.” Notably, Langton's analysis of various speech acts in terms of his semiotic (or pragmatic) theory is also a basis to formulate the conditions of happiness of the act of blessing (understood in the theological context), which shows that logic can be not only broadly applicable, but also effective. Finally, question 103 proves that logic is universal also in a different way, namely: it can provide solutions which are acceptable for representatives of different traditions.https://cassyni-user-files-prod.s3.amazonaws.com/GmVZGnpPyVy7q8EJhdXPkS https://cassyni.com/slides/outline/62mywZk3efsYJTJtxHycku https://cassyni.com/events/62mywZk3efsYJTJtxHycku/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Vj1c8prU7BE1cP7jtWYLNi https://cassyni.com/events/62mywZk3efsYJTJtxHycku?videoPreview=1 Faecal microbial transfer and complex carbohydrates mediate protection against COPDnohttps://cassyni.com/events/62mywZk3efsYJTJtxHycku?videoPreview=12024-12-04T14:00:00+00:00710.0Microbiome Virtual International ForumObjective: Chronic obstructive pulmonary disease (COPD) is a major cause of global illness and death, most commonly caused by cigarette smoke. The mechanisms of pathogenesis remain poorly understood, limiting the development of effective therapies. The gastrointestinal microbiome has been implicated in chronic lung diseases via the gut-lung axis, but its role is unclear. Design: Using an in vivo mouse model of cigarette smoke (CS)-induced COPD and faecal microbial transfer (FMT), we characterised the faecal microbiota using metagenomics, proteomics and metabolomics. Findings were correlated with airway and systemic inflammation, lung and gut histopathology and lung function. Complex carbohydrates were assessed in mice using a high resistant starch diet, and in 16 patients with COPD using a randomised, double-blind, placebo-controlled pilot study of inulin supplementation. Results: FMT alleviated hallmark features of COPD (inflammation, alveolar destruction, impaired lung function), gastrointestinal pathology and systemic immune changes. Protective effects were additive to smoking cessation, and transfer of CS-associated microbiota after antibiotic-induced microbiome depletion was sufficient to increase lung inflammation while suppressing colonic immunity in the absence of CS exposure. Disease features correlated with the relative abundance of Muribaculaceae, Desulfovibrionaceae and Lachnospiraceae family members. Proteomics and metabolomics identified downregulation of glucose and starch metabolism in CS-associated microbiota, and supplementation of mice or human patients with complex carbohydrates improved disease outcomes. Conclusion: The gut microbiome contributes to COPD pathogenesis and can be targeted therapeutically.https://cassyni-user-files-prod.s3.amazonaws.com/Vj1c8prU7BE1cP7jtWYLNi https://cassyni.com/events/WjCCFk6HbZZVTubdUWZiSZ/abstract https://cassyni-user-files-prod.s3.amazonaws.com/RYqrMusF4dVFpnRwXRzNEJ https://cassyni.com/events/SHJWcLEnqijCnyjCGoLVL9/seminar/qa https://cassyni.com/slides/outline/SHJWcLEnqijCnyjCGoLVL9 https://cassyni.com/events/SHJWcLEnqijCnyjCGoLVL9/abstract https://cassyni-user-files-prod.s3.amazonaws.com/PDCc2iktLPZfx4wv669KUA https://cassyni.com/events/SHJWcLEnqijCnyjCGoLVL9?videoPreview=1 Science and innovation in Sub-Saharan Africanohttps://cassyni.com/events/SHJWcLEnqijCnyjCGoLVL9?videoPreview=12025-09-18T09:00:00+00:005156.84Royal Society PublishingJoin us for this virtual seminar exploring the *Interface Focus* theme issue, Science and innovation in Sub-Saharan Africa. We will hear from authors of two papers within the theme issue, as well as explore the topic during a roundtable of experts with different perspectives in the space. https://cassyni-user-files-prod.s3.amazonaws.com/PDCc2iktLPZfx4wv669KUA https://cassyni.com/slides/outline/3ZXxi9WRTP71GJ57VWBFkh https://cassyni.com/events/3ZXxi9WRTP71GJ57VWBFkh/abstract https://cassyni-user-files-prod.s3.amazonaws.com/6MarW52LFcrQaMEsnEDhF4 https://cassyni.com/events/3ZXxi9WRTP71GJ57VWBFkh?videoPreview=1 Reproducibility, Transparency, Positionality? Perspectives From Different Research Fieldsnohttps://cassyni.com/events/3ZXxi9WRTP71GJ57VWBFkh?videoPreview=12024-04-18T03:00:00+00:006402.68UKRNThe word ‘reproducibility’ in UKRN’s name can prompt discussion and even concern that our vision, of a research system that promotes rigour and transparency, excludes some kinds of research. Certainly, many of UKRN’s origins lie in the so-called ‘reproducibility crisis’ in, for example, psychology. However, it seems clear that characteristics of research such as transparency in method and findings, and acknowledging and handling factors that might confound those findings, are common concerns related to rigour in many – if not all – research fields. In this webinar, speakers from arts practice, astronomy, psychology, and qualitative social sciences outline their perspectives on these questions, with the aim of highlighting both diversity and perhaps surprising commonalities. The webinar marks the release of a new UKRN working paper, based on a recent facilitated dialogue between arts practice and psychology researchers, sponsored by the British Psychological Society , the Practice Research Advisory Group, and UKRN.https://cassyni-user-files-prod.s3.amazonaws.com/6MarW52LFcrQaMEsnEDhF4 https://cassyni.com/slides/outline/Fuk4sEgYRpws9yJvTrjytq https://cassyni.com/events/Fuk4sEgYRpws9yJvTrjytq/abstract https://cassyni-user-files-prod.s3.amazonaws.com/5ccSw3Z3bS2DPeXz6pZB9Q https://cassyni.com/events/Fuk4sEgYRpws9yJvTrjytq?videoPreview=1 Contributions To Research By Human And AI Produced Lay Summaries Webinarnohttps://cassyni.com/events/Fuk4sEgYRpws9yJvTrjytq?videoPreview=12023-10-19T03:00:00+00:006551.84UKRNSummaries of research for a lay, non-expert audience can improve the research process. Benefits may include helping other researchers understand a new topic; aid students or early career researchers in critically appraising and sharing their research; or communicating research to the wider public. In this webinar, experts will share their work on the creation of lay summaries and how they contribute to improving research. Crucially, we will discuss the implications of both human and generative AI-produced summaries.https://cassyni-user-files-prod.s3.amazonaws.com/5ccSw3Z3bS2DPeXz6pZB9Q https://cassyni.com/events/MLuLVPKCfDxzRrb7m3vKUq/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Qbkf1F6guwfxMpfevzvo9Y https://cassyni.com/slides/outline/KqZPdrcKCozQjoyBASTijw https://cassyni.com/events/KqZPdrcKCozQjoyBASTijw/abstract https://cassyni-user-files-prod.s3.amazonaws.com/9NLzXPLx45112YG829xRnN https://cassyni.com/events/KqZPdrcKCozQjoyBASTijw?videoPreview=1 The Launch Phase of the Microbiota Vaultnohttps://cassyni.com/events/KqZPdrcKCozQjoyBASTijw?videoPreview=12025-09-09T12:50:00+00:00902.12Microbiome Virtual International ForumThe Microbiota Vault Initiative (MVI) is a non-profit organization dedicated to safeguarding naturally evolved microbial diversity for future research and potential restoration of microbial diversity. During its two-year Launch Phase, MVI partnered with Local Working Collections (LWCs) in Benin, Brazil, Ethiopia, Ghana, Laos, Thailand, and Switzerland, who deposited more than 1,171 human fecal specimens and 190 fermented-food samples, which are securely stored at −80°C in a biobank in Zurich. The Launch Phase established a set of standard operating procedures (SOPs) for sample collection, transport, and metadata reporting for human stool and fermented foods, and evaluated sample preservation methods for long-term storage for maintaining microbial viability. The MVI aims to expand microbial research to underrepresented communities to support inclusivity and globally representation. https://cassyni-user-files-prod.s3.amazonaws.com/9NLzXPLx45112YG829xRnN https://cassyni.com/slides/outline/XDsRR4FhSP3KHNb9Gcggcm https://cassyni.com/events/XDsRR4FhSP3KHNb9Gcggcm/abstract https://cassyni-user-files-prod.s3.amazonaws.com/J7ETiVSnU5X8f1seR9NMyQ https://cassyni.com/events/XDsRR4FhSP3KHNb9Gcggcm?videoPreview=1 Uniform bacterial genetic diversity along the guts of mice inoculated with human stoolnohttps://cassyni.com/events/XDsRR4FhSP3KHNb9Gcggcm?videoPreview=12025-06-03T00:30:00+00:00571.88Microbiome Virtual International ForumEnvironmental gradients exist throughout the digestive tract, driving spatial variation in the membership and abundance of bacterial species along the gut. However, less is known about the distribution of genetic diversity within bacterial species along the gut. Understanding this distribution is important because bacterial genetic variants confer traits important for the functioning of the microbiome and are also known to impart phenotypes to the hosts, including local inflammation along the gut and the ability to digest food. Thus, to be able to understand how the microbiome functions at a mechanistic level, it is essential to understand how genetic diversity is organized along the gut and the ecological and evolutionary processes that give rise to this organization. In this study, we analyzed bacterial genetic diversity of approximately 30 common gut commensals in five regions along the gut lumen in germ-free mice colonized with the same healthy human stool sample. While species membership and abundances varied considerably along the gut, genetic diversity within species was substantially more uniform. Driving this uniformity were similar strain frequencies along the gut, implying that multiple, genetically divergent strains of the same species can coexist within a host without spatially segregating. Additionally, the approximately 60 unique evolutionary adaptations arising within mice tended to sweep throughout the gut, showing little specificity for particular regions. Together, our findings show that genetic diversity may be more uniform along the gut than species diversity, which implies that species presence-absence may play a larger role than genetic variation in responding to spatially varied environmental pressures in the gut microbiome.https://cassyni-user-files-prod.s3.amazonaws.com/J7ETiVSnU5X8f1seR9NMyQ https://cassyni.com/events/CwVM6x6sZPanYK8xpJx1uo/abstract https://cassyni-user-files-prod.s3.amazonaws.com/yGKsV97VBwxcxwEJQGw74 https://cassyni.com/slides/outline/NoRPoKyaSCPDwjhP4A7NsP https://cassyni.com/events/NoRPoKyaSCPDwjhP4A7NsP/abstract https://cassyni-user-files-prod.s3.amazonaws.com/N99QRE1Umi5LpCbdAva36W https://cassyni.com/events/NoRPoKyaSCPDwjhP4A7NsP?videoPreview=1 Understanding the impact of targeted SDOH Training among RNs in the USnohttps://cassyni.com/events/NoRPoKyaSCPDwjhP4A7NsP?videoPreview=12025-09-07T20:00:00+00:00949.24Sage PublishingNurses can play a substantial role in addressing social determinants of health (SDOH) through patient interactions and care; however, limited training opportunities exist for professional nurses on SDOH. The purpose of this project was to develop free online learning modules related to addressing SDOH in patient care and evaluate changes in competency levels. On average, professional nurses reported a 0.55-point increase in competency scores across SDOH topics encouraging the development of additional trainings related to SDOH.https://cassyni-user-files-prod.s3.amazonaws.com/N99QRE1Umi5LpCbdAva36W https://cassyni.com/events/Qn1oz4ZgC2bz3SycR7yKHw/abstract https://cassyni-user-files-prod.s3.amazonaws.com/FqaA8VL2ZRJHJVHtzxx1An https://cassyni.com/slides/outline/YBjsgKGYmtuVoVAWyHawk1 https://cassyni.com/events/YBjsgKGYmtuVoVAWyHawk1/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Y1XVisVpVT9FCVP3vEJt2a https://cassyni.com/events/YBjsgKGYmtuVoVAWyHawk1?videoPreview=1 Introduction to correlation networks: Interdisciplinary approaches beyond thresholdingnohttps://cassyni.com/events/YBjsgKGYmtuVoVAWyHawk1?videoPreview=12025-08-20T04:00:00+00:003886.12Physics ReportsMany empirical networks originate from correlational data, arising in domains as diverse as psychology, neuroscience, genomics, microbiology, finance, and climate science. Specialized algorithms and theory have been developed in different application domains for working with such networks, as well as in statistics, network science, and computer science, often with limited communication between practitioners in different fields. This leaves significant room for cross-pollination across disciplines. A central challenge is that it is not always clear how to best transform correlation matrix data into networks for the application at hand, and probably the most widespread method, i.e., thresholding on the correlation value to create either unweighted or weighted networks, suffers from multiple problems. In this article, we review various methods of constructing and analyzing correlation networks, ranging from thresholding and its improvements to weighted networks, regularization, dynamic correlation networks, threshold-free approaches, comparison with null models, and more. Finally, we propose and discuss recommended practices and a variety of key open questions currently confronting this field.https://cassyni-user-files-prod.s3.amazonaws.com/Y1XVisVpVT9FCVP3vEJt2a https://cassyni.com/slides/outline/DR6uvLgc6VrzmCzU48XYH3 https://cassyni.com/events/DR6uvLgc6VrzmCzU48XYH3/abstract https://cassyni-user-files-prod.s3.amazonaws.com/6BSqTraVn2RxCrAeHerr5U https://cassyni.com/events/DR6uvLgc6VrzmCzU48XYH3?videoPreview=1 Rethinking Thecodonty: the influence of two centuries of comparative dental anatomy on our understanding of tooth evolutionnohttps://cassyni.com/events/DR6uvLgc6VrzmCzU48XYH3?videoPreview=12025-09-20T22:00:00+00:002821.68Royal Society Publishing‘Thecodont’ refers to teeth implanted in sockets within the jaw, a condition traditionally associated with living mammals and crocodylians, which also coincidentally have teeth attached by ligaments to the socket walls (gomphosis). For over a century, the bony periodontium of many other amniotes has been described as a single tissue, ‘bone of attachment’, causing confusion over dental tissue homology. The conventional definitions of ‘thecodonty’ exclude species with fused teeth (‘ankylothecodonts’), implying a fundamental difference between mammals, crocodylians, and most other vertebrates. However, the stereotypically ‘thecodont’ attachment tissues have been discovered in representatives of all major amniote clades, showing that gomphosis and ankylosis likely stem from heterochronic changes in the timing and extent of cementum and alveolar bone mineralization. This challenges (i) previous hypotheses regarding the evolution of the amniote periodontium, (ii) the ‘bone of attachment’ paradigm, and (iii) the significance of ‘thecodonty’. We suggest a new nomenclatural approach that incorporates recent histological and evolutionary research and divides thecodonty into anatomical categories to clarify their origin and evolution. We propose the terms anisothecodont and isothecodont to denote, respectively, asymmetric and symmetric implantation of teeth in their sockets. Regardless of the geometry of the connection, we propose using ankylosis and gomphosis to denote the mode of tooth attachment.https://cassyni-user-files-prod.s3.amazonaws.com/6BSqTraVn2RxCrAeHerr5U https://cassyni.com/slides/outline/WDB5cDCLRRcqGKGKBYQcRT https://cassyni.com/events/WDB5cDCLRRcqGKGKBYQcRT/abstract https://cassyni-user-files-prod.s3.amazonaws.com/AdhZesN5bmM3hrmvHZDSJa https://cassyni.com/events/WDB5cDCLRRcqGKGKBYQcRT?videoPreview=1 Assessing adherence to good pharmacy practices in a provincial hospital in Nepal: A quality improvement perspective nohttps://cassyni.com/events/WDB5cDCLRRcqGKGKBYQcRT?videoPreview=12025-09-17T02:00:00+00:00989.48Sage PublishingAuthors: Nabin Pathak, Prerana Shrestha, Shreya Dhungana, Sunil Shrestha Introduction Several pharmacy standards exist within high-income countries for measuring standards of practice with clinical and hospital settings. Following the implementation of diverse hospital pharmacy standards in low- and middle-income countries (LMICs) like Nepal such as the hospital pharmacy service guideline 2015, minimum service standards, this study aims to assess compliance with Good Pharmacy Practice (GPP) standards as per the codes for sales and distribution of drugs (CSDD) 2024 guideline in one of the provincial hospital of Nepal, as a quality improvement project. Methods A cross-sectional study design was conducted within Hetauda Hospital pharmacy section to check the compliance nature of hospital pharmacy practice standards using the 16 components and 121 indicators mentioned in the CSDD, implemented by the National Drug Regulatory Authority of Nepal, Department of Drug Administration. CSDD is a publicly available guideline consisting of five chapters and twenty sections where the codes specifically focus on structural, human resources, storage and documentation, pharmacovigilance, GPP, good storage and distribution practice license-related provisions. Following the checklist provided in the CSDD, data were collected and entered into the MS Excel and analyzed in terms of frequency and percentage compliance. If the indicators were found to be 100% compliant, it was categorized as fully compliant, if the indicators were scored from (>50% - 99.9%), it was categorized as partially compliant whereas if it was in between (0.0% - ≤50%), it was categorized as poorly compliant. Results Out of a total of 121 indicators mentioned in the CSDD, only 74 (61.2%) were compliant. Only six domains were fully compliant (100%), whereas seven domains were partially compliant (≥50% - 99.9%) and ten domains were poorly compliant (<50 - 0.0%). Conclusion Following the CSDD guidelines, it was found that the hospital pharmacy lacked in domains such as quality policy, service strategy, training, client complaints, product recalls, counseling services, medication records, client follow-up and referral, and self-inspection process, underscoring the need for prompt attention and action plan from the Drug and Therapeutic Committee and the executives. https://cassyni-user-files-prod.s3.amazonaws.com/AdhZesN5bmM3hrmvHZDSJa https://cassyni.com/slides/outline/Zbf3CBnNERjWzne3PXHTB https://cassyni.com/events/Zbf3CBnNERjWzne3PXHTB/abstract https://cassyni-user-files-prod.s3.amazonaws.com/N97yLH7ika2KQLWtbQPiVc https://cassyni.com/events/Zbf3CBnNERjWzne3PXHTB?videoPreview=1 Improved allele frequencies in gnomAD through local ancestry inferencenohttps://cassyni.com/events/Zbf3CBnNERjWzne3PXHTB?videoPreview=12025-12-04T16:05:46+00:00997.24Research Seminars by Springer NatureThe Genome Aggregation Database (gnomAD) is a foundational resource for allele frequency data, widely used in genomic research and clinical interpretation. However, traditional estimates rely on individual-level genetic ancestry groupings that may obscure variation in recently admixed populations. To improve resolution, we applied local ancestry inference (LAI) to over 27 million variants in two admixed groups: Admixed American (n = 7612) and African/African American (n = 20,250), deriving ancestry-specific allele frequencies. We show that 78.5% and 85.1% of variants in these groups, respectively, exhibit at least a twofold difference in ancestry-specific frequencies. Moreover, 81.49% of variants with LAI information would be assigned a higher gnomAD-wide maximum frequency after incorporating LAI, potentially altering clinical interpretations. This LAI-informed release reveals clinically relevant frequency differences that are masked in aggregate estimates and may support reclassifying some variants from Uncertain Significance to Benign or Likely Benign.https://cassyni-user-files-prod.s3.amazonaws.com/N97yLH7ika2KQLWtbQPiVc https://cassyni.com/slides/outline/JMfpj4hWhABa1oUeCxo2NR https://cassyni.com/events/JMfpj4hWhABa1oUeCxo2NR/abstract https://cassyni-user-files-prod.s3.amazonaws.com/8Hhjyxf9ci34zTeV2byhgi https://cassyni.com/events/JMfpj4hWhABa1oUeCxo2NR?videoPreview=1 Transient and periodic shear wave propagation in a solid–fluid coupled systemnohttps://cassyni.com/events/JMfpj4hWhABa1oUeCxo2NR?videoPreview=12026-02-16T07:00:00+00:001174.0Royal Society PublishingA coupled system composed of a Newtonian fluid located on a sinusoidally forced elastic solid is studied analytically and numerically. The focus is on the transient evolution from the beginning of the forced oscillations and on the periodic behaviour established once the transient has vanished. The analytical solution is expressed as series summations that elucidate the propagation and reflections of elastic transverse waves through the solid layer and the viscous dissipation of oscillations in the fluid layer. Short-term transients in both the fluid and the solid form at every interaction between an elastic wave and a solid boundary. The long-term transient, quantified by the power balance in the fluid layer, instead pertains to the formation of all the elastic waves in the solid layer. The system can be viewed as a generalized transient Stokes layer generated by the elastic waves or as a damped resonant oscillator when the velocity at the fluid–solid interface increases significantly with respect to the forcing amplitude. A parametric study is carried out for three applications of technological interest, i.e. the indirect measurement of fluid viscosity, the turbulent drag reduction by travelling shear waves and the sensing and manipulation of biological flows.https://cassyni-user-files-prod.s3.amazonaws.com/8Hhjyxf9ci34zTeV2byhgi https://cassyni.com/events/VDw7k6w4MEN3Y5JfpW2iKF/abstract https://cassyni-user-files-prod.s3.amazonaws.com/RNuDxidddw2fwcEJEQBZFL https://cassyni.com/events/VDw7k6w4MEN3Y5JfpW2iKF?videoPreview=1 Accurate calculation of the gradients of the equilibrium poloidal flux in tokamaks nohttps://cassyni.com/events/VDw7k6w4MEN3Y5JfpW2iKF?videoPreview=12026-02-05T17:00:00+00:001708.4Computer Physics CommunicationsThis paper presents a novel method for calculating the first, second, and third derivatives of the equilibrium poloidal flux in different directions in tokamaks. The method is implemented in a new code called Equilibrium Derivative in Arbitrary Mesh (EDAM) which is designed for practical fusion applications. The spectral method is adopted along the boundary with evenly spaced angles, while unstructured triangular meshes are used inside the computational domain. A new boundary integral equation (BIE) is derived and solved numerically to obtain the first and higher-order derivatives at the boundary. Using GS equation, linear partial differential equations for the first and higher-order flux derivatives are then constructed and solved. Validation is performed using an analytical equilibrium constructed by Cicogna, which describes D-shaped plasmas with steep profiles near the boundary. The code demonstrates similar convergence rates for the first and higher-order derivatives, achieving second order accuracy. This new method has significant potential for practical fusion simulations, providing derivatives up to the third order with the required accuracy and precisely given values at any nodal points of the unstructured mesh.https://cassyni-user-files-prod.s3.amazonaws.com/RNuDxidddw2fwcEJEQBZFL https://cassyni.com/slides/outline/5WXtNzj1FeWyabsvYaXX8H https://cassyni.com/events/5WXtNzj1FeWyabsvYaXX8H/abstract https://cassyni-user-files-prod.s3.amazonaws.com/8Shv3DpWMi2TcCmbpcthJW https://cassyni.com/events/5WXtNzj1FeWyabsvYaXX8H?videoPreview=1 Exploring functional insights into the human gut microbiome via the structural proteomenohttps://cassyni.com/events/5WXtNzj1FeWyabsvYaXX8H?videoPreview=12026-05-12T14:00:00+00:00629.8Microbiome Virtual International ForumThe human gut microbiome contains numerous proteins whose functions remain elusive yet are pivotal for host health. Sequence-based methods often falter when attempting to infer functions within this microbial proteome due to evolutionary divergence. To address this challenge, we develop the Human Gut Microbial Protein Structure Database, which incorporates ~2.7 million predicted protein structures. Our findings reveal that structural analogy enhances the annotation of phage proteins. We detail the structural diversification of phage endolysins and confirm their potential in eliminating gut pathobionts. Furthermore, our structure-guided approach is effective in the identification of microbial-host isozymes. By employing structural alignments, we identify previously unrecognized bacterial enzymes involved in melatonin biosynthesis. Finally, we present an alignment-free method, Dense Enzyme Retrieval, based on structure-encoded protein language models for ultrafast and sensitive detection of remote homologs. Our research underscores the value of computational structural genomics in elucidating the functional landscape of the human gut microbiome.https://cassyni-user-files-prod.s3.amazonaws.com/8Shv3DpWMi2TcCmbpcthJW https://cassyni.com/slides/outline/WhWqPyB7RuyteXYwftmDWm https://cassyni.com/events/WhWqPyB7RuyteXYwftmDWm/abstract https://cassyni-user-files-prod.s3.amazonaws.com/AGJAAhFFNYFq6AviPZqe7G https://cassyni.com/events/WhWqPyB7RuyteXYwftmDWm?videoPreview=1 Allometric scales underlying animal flight: a mechanics-based approachnohttps://cassyni.com/events/WhWqPyB7RuyteXYwftmDWm?videoPreview=12026-03-23T06:00:00+00:002003.72Royal Society PublishingOver the years, numerous studies have attempted to deduce scaling laws for the parameters associated with animal flight. These have been primarily empirical and have, moreover, tended to focus on one of the three volant groups, i.e. birds, bats or insects, with few attempts to seek common scaling behaviours. On the premise that there are underlying fundamental scales enabling animal flight regardless of species, a unified approach based on the mechanics of flight is developed. It is shown that the primary physical phenomena can be described in terms of four morphological parameters, the mass scalings of which are allometric. Comparison with data demonstrates that the theoretical scales hold across a broad range of extant species spanning eight orders of magnitude in size. The scales are also found to apply to extinct animals, suggesting that they are a necessary requirement for animal volancy. Additionally, the theory enables the determination of scales for other quantities, including the density, muscle strain and various aspects of the power. These scales are found to be consistent with previous, hitherto unexplained, observations. Finally, the present approach enables conclusions to be drawn regarding certain features of extinct animals, including their size and mode of flight.https://cassyni-user-files-prod.s3.amazonaws.com/AGJAAhFFNYFq6AviPZqe7G https://cassyni.com/slides/outline/ZHonGX2wGEjuSYNwJb6HB https://cassyni.com/events/ZHonGX2wGEjuSYNwJb6HB/abstract https://cassyni-user-files-prod.s3.amazonaws.com/V61J7nUU3vPbVbXKsTCwNn https://cassyni.com/events/ZHonGX2wGEjuSYNwJb6HB?videoPreview=1 Modeling the spatial growth of citiesnohttps://cassyni.com/events/ZHonGX2wGEjuSYNwJb6HB?videoPreview=12026-04-21T14:00:00+00:002738.72Physics ReportsThe growth of cities has traditionally been studied from a population perspective, while urban expansion—its spatial growth—has often been approached qualitatively. However, characterizing and modeling this spatial expansion is crucial, particularly given its parallels with surface growth extensively studied in physics. Despite these similarities, approaches to urban expansion modeling are fragmented and scattered across various disciplines and contexts. In this seminar, I will provide a comprehensive overview of the mathematical modeling of this complex phenomenon. We discuss the key challenges hindering progress and examine models inspired by statistical physics, economics and geography, and theoretical ecology. Finally, I will highlight critical directions for future research in this interdisciplinary field.https://cassyni-user-files-prod.s3.amazonaws.com/V61J7nUU3vPbVbXKsTCwNn https://cassyni.com/events/Rm63APjdr4JQtpkr4kiZcR/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Vp5r5DPEvn2roc4a8FoX1x https://cassyni.com/events/Etpk9MW6Bz7UcMJbJCZarq/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Fv9q99P5PQWUtonRer6VFC https://cassyni.com/slides/outline/23zf4DCLBSeLYuaMtv9ZbT https://cassyni.com/events/23zf4DCLBSeLYuaMtv9ZbT/abstract https://cassyni-user-files-prod.s3.amazonaws.com/QidAtYu4oPzLMMEDjUxEpW https://cassyni.com/events/23zf4DCLBSeLYuaMtv9ZbT?videoPreview=1 An unrecognised fine-scale host-plant adaptation in a leaf-miner: correct dorsoventral egg orientation is essential for successful leaf entrynohttps://cassyni.com/events/23zf4DCLBSeLYuaMtv9ZbT?videoPreview=12026-06-29T07:36:53+00:00501.2Royal Society PublishingLarvae of leaf miners live within leaves and feed on internal tissues, making successful entry into the leaf essential for their endophagous lifestyle. In the leaf-mining moth Acrocercops transecta, females lay eggs on the surface of host-plant leaves. Immediately after hatching, larvae penetrate the leaf directly through the eggshell, representing the only opportunity to enter host leaves. Under laboratory conditions, we observed substantial mortality caused by failure of leaf entry. The nearly transparent eggshell of A. transecta enabled observation of embryonic development, revealing that correct dorsoventral orientation, ventral side facing the leaf epidermis, is essential for successful mining, whereas inverted orientation leads to failure. We developed a novel egg transplantation method and showed that correcting inverted embryos by flip transplantation restored mining success, while inverting normally oriented embryos prevented it. Notably, inverted embryos were also observed under natural conditions, causing mortality in first-instar larvae. Furthermore, under laboratory conditions, the mortality rates differed between the horticultural host Juglans regia and the natural host J. mandshurica. These results reveal a previously unrecognised source of mortality in leaf miners and demonstrate that precise dorsoventral orientation during oviposition is essential for offspring survival, highlighting a fine-scale egg-loading mechanism shaping successful host adaptation in insects.https://cassyni-user-files-prod.s3.amazonaws.com/QidAtYu4oPzLMMEDjUxEpW https://cassyni.com/events/MKN6CkyTWP22MAcHM7RMwK/abstract https://cassyni-user-files-prod.s3.amazonaws.com/BfntMStTFPBhc6bhhw5Vav https://cassyni.com/events/7VgkrKcq4hFuBoQZLFR8hs/abstract https://cassyni-user-files-prod.s3.amazonaws.com/HDAPigdfYMLD5JhjvXqpTY https://cassyni.com/events/439XXY69zVPGA76zgb3BB3/abstract https://cassyni-user-files-prod.s3.amazonaws.com/HKi9muhHc3Z4K1nTTepRs4 https://cassyni.com/events/Jrpdq5czP7QhgHdfgVF6b7/seminar/qa https://cassyni.com/slides/outline/Jrpdq5czP7QhgHdfgVF6b7 https://cassyni.com/events/Jrpdq5czP7QhgHdfgVF6b7/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Tdcgn6i5SyYY5MMc2Cnggv https://cassyni.com/events/Jrpdq5czP7QhgHdfgVF6b7?videoPreview=1 Event-based imaging velocimetry: A new approach to flow diagnostics based on particle imagingnohttps://cassyni.com/events/Jrpdq5czP7QhgHdfgVF6b7?videoPreview=12022-10-25T14:00:00+00:003717.52Experiments in FluidsEvent-based vision (EBV), also referred to as dynamic vision sensing (DVS), is a rather recent emerging, bio-inspired technology in the field of computer vision that has already found numerous applications in areas such as autonomous navigation, high-speed object counting, star tracking, 3D sensing or vibration monitoring. Unlike the framing sensor in a conventional camera, the detector of an EBV camera only reacts to contrast changes producing “on” or “off” events at the pixel level with microsecond resolution. With each pixel operating individually, the output data stream is asynchronous, containing pixel coordinates, event time and polarity of the contrast change. In the context of imaging small particles in fluid flows, the event data stream essentially provides continuous real-time particle tracking data as already demonstrated by a few other research groups. The focus of this presentation is the assessment of EBV in the context of providing dense fields of time-resolved velocity data and includes demonstrations on simple water and air flows. Several (off-line) processing algorithms for extracting flow field data from the asynchronous data stream are explored. Measurements at equivalent frame rates in the 2-5 kHz-range are feasible. The currently available hardware does however impose some limitations, most notably, when exceeding the available camera bandwidth while imaging densely seeded flows. This and other unique aspects of the new imaging approach will be addressed in the presentation along with possible mitigation strategies. Beyond the more quantitative applications on simple water and air flows explored here, EBV offers considerable potential as a tool for flow visualization and should be readily useable for educational purposes, in particular, in combination with eye-safe light sources such as LED illumination.https://cassyni-user-files-prod.s3.amazonaws.com/Tdcgn6i5SyYY5MMc2Cnggv https://cassyni.com/slides/outline/GtFqkyYn2e838p9cvuTS3P https://cassyni.com/events/GtFqkyYn2e838p9cvuTS3P/abstract https://cassyni-user-files-prod.s3.amazonaws.com/NgHsjrgyvwGqm7ATbdcDXk https://cassyni.com/events/GtFqkyYn2e838p9cvuTS3P?videoPreview=1 Circular Economy as a platform for impactful and cross-disciplinary researchnohttps://cassyni.com/events/GtFqkyYn2e838p9cvuTS3P?videoPreview=12022-11-23T01:00:00+00:006619.36Faculty of Business and EconomicsOver the last few decades, the debate on enhancing sustainability in global industrial systems has gained momentum in the practitioners, policymakers and scientists’ arenas. There are at least three dominant themes within this discourse that directly involve business strategies: First, evidence-based sustainability research has progressively informed practitioners’ decisions, moving from a peripheral and reactive to a central and pro-active sustainability approaches. Sustainability is now viewed as a ‘science-led’ strategic approach in many of the large corporates with global or international scope. Second, sustainability has become more subject to different worldviews, de facto influenced by the interaction of multiple stakeholders jointly interested in, or in need of, tackling socio-ecological crises. Third, sustainability has become one of the pillars of the discussion around the emergence of the Anthropocene, a geological era starting with the industrial revolution of the 18th century and conditioned by anthropic activities, most notably, a massive emission of greenhouse gases and pollutants able to alter Planetary ecosystems and cycles. These themes have stimulated the emergence of the academic debate on the relationship between businesses and planetary boundaries and, in parallel, increased interest in the idea of the Circular Economy (CE) as an ideal state of a zero-waste economy. Principles of the CE include the use of renewable energies, eliminating toxic chemicals and eradicating waste by maximising reuse, repair, remake and recycling. While there are some critical voices in the academic community that question the feasibility of the CE model and point to its contested nature (see for instance, Corvellec et al., 2021; Korhonen et al. 2018), there is also a major increase in CE publications across disciplines from engineering to environmental science to innovation and business model research (Bocken et al. 2013; Kirchherr et al. 2017) and an increasing push from organizations and governments to adopt the circular imperative (European Commission, 2020). In this research workshop, we will discuss and ideate how the Circular Economy concept can inform business research at the University of Auckland Business School. We will hear from Stefano Pascucci, Ken Webster and Jan Jonker about their approaches to and visions of the Circular Economy. Then, Ken Webster and Kenneth Husted will guide us through a research ideation workshop. https://cassyni-user-files-prod.s3.amazonaws.com/NgHsjrgyvwGqm7ATbdcDXk https://cassyni.com/events/34rjYqM1cZdBSq5bhQ4HaV/seminar/qa https://cassyni.com/slides/outline/34rjYqM1cZdBSq5bhQ4HaV https://cassyni.com/events/34rjYqM1cZdBSq5bhQ4HaV/abstract https://cassyni-user-files-prod.s3.amazonaws.com/4hHmKZgWtot7c4V47oqwEv https://cassyni.com/events/34rjYqM1cZdBSq5bhQ4HaV?videoPreview=1 Health Equitynohttps://cassyni.com/events/34rjYqM1cZdBSq5bhQ4HaV?videoPreview=12024-12-11T14:30:00+00:003323.48Sage PublishingThis seminar will introduce our cross-journal Special Collection on Health Equity, held across our portfolio of open access public health and nursing journals. Featuring some of our expert Guest Editors from the series, we will discuss the key current topics and future directions in health equity by addressing the pressing questions facing this critical area of public health research. This seminar and associated Special Collection seek to explore, highlight, and advance the understanding of the various dimensions and determinants of health equity within public health, nursing, and health professions. Our aim is to disseminate research that addresses the root causes of health disparities and promotes strategies to achieve equitable health outcomes for all populations. We are excited to announce that our joint Special Collection on Health Equity is now open for submissions. Authors are invited to submit their work to any of the following eight Gold Open Access journals: - [The Journal of Public Health Research](https://journals.sagepub.com/topic/collections-phj/phj-1-cross_journal_special_collection_on_health_equity?journalCode=phj) - [Health Services Insights](https://journals.sagepub.com/topic/collections-his/his-1-cross-journal_special_collection_on_healthy_equity?journalCode=his) - [INQUIRY](https://journals.sagepub.com/topic/collections-inq/inq-1-cross_journal_special_collection_on_health_equity?journalCode=inq) - [Journal of Primary Care and Community Health](https://journals.sagepub.com/topic/collections-jpc/jpc-1-cross_journal_special_collection_on_health_equity?journalCode=jpc) - [The Journal of Medicine Access](https://journals.sagepub.com/topic/collections-map/map-1-cross_journal_special_collection_on_health_equity?journalCode=map) - [American Journal of Men’s Health](https://journals.sagepub.com/topic/collections-jmh/jmh-1-cross_journal_special_collection_on_health_equity?journalCode=jmh) - [Women’s Health](https://journals.sagepub.com/topic/collections-whe/whe-1-cross_journal_special_collection_on_health_equity?journalCode=whe) - [Digital Health](https://journals.sagepub.com/topic/collections-dhj/dhj-1-cross_journal_special_collection_on_health_equity?journalCode=dhj) The scope of this Special Collection series encompasses a broad range of topics related to health equity, including investigations into social determinants of health, evaluations of health policies, community-driven initiatives, analyses of health systems and services, global health comparisons, innovative interventions, training/education innovations, theoretical perspectives, and new methodologies for addressing health inequities. We invite submissions from researchers, practitioners, policymakers, and community leaders who are engaged in advancing health equity through innovative research, education and practice. You may choose from our list of eight gold open access journals and submit directly to the most relevant one for your research. Articles accepted for publication following peer review will be hosted on each journal’s website and a cross-journal landing page, as well as disseminated widely to the relevant audience.https://cassyni-user-files-prod.s3.amazonaws.com/4hHmKZgWtot7c4V47oqwEv