https://cassyni.com/slides/outline/DgD9eJwBbL5QQc5vCcrbLq https://cassyni.com/events/DgD9eJwBbL5QQc5vCcrbLq/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Y8h1EXfNasi8mTfCQWWNKY https://cassyni.com/events/DgD9eJwBbL5QQc5vCcrbLq?videoPreview=1 Environmental decision support: rare events, monitoring and inversion, and uncertainty quantificationnohttps://cassyni.com/events/DgD9eJwBbL5QQc5vCcrbLq?videoPreview=12021-11-17T11:00:00+00:002826.24Data-Centric Engineering JournalEnvironmental data science offers the opportunity to combine theory and measurement in characterising our natural environment rationally and quantitatively, to understand its evolution, and to take decisions regarding our interactions with it wisely in the presence of uncertainty. The practical challenge is to develop and adapt ideas from statistical theory and method to address complex problems in the natural environment in a physically realistic manner, creating useful tools to quantify risk, and support real-world decision making. Characterising rare events from observations is problematic by definition, since their rate of occurrence is low. In an environmental context, we discuss how extreme value theory is used to understand extreme ocean storms, floods, heat-waves and earthquakes. Practical application of extreme value methods numerous significant challenges, including the estimation of extreme value threshold, non-stationarity with respect to multiple covariates, and reliable characterisation of extremal dependence. These challenges become ever more acute as the numbers of responses and covariates increase. Given observational data for thousands of variables of interest in some applications, the computational complexity of extreme value analysis is enormous. Remote sensing technologies including satellite, airborne, line-of-site and point) provide observations of the earth’s atmosphere and surface at different scales and resolutions. We discuss how these data sources are used in statistical models to detect, locate and quantify sources of natural and manmade methane and carbon dioxide emissions into the atmosphere, and to monitor atmospheric concentrations within specific domains. Bayesian inference provides a natural framework for learning about large-scale physical systems, to quantify uncertainty in predictions regarding those systems, and to facilitate optimal decision-making. We discuss how the computational complexity of practical inference is managed by the adoption of suitable modelling frameworks and efficient numerical schemes.https://cassyni-user-files-prod.s3.amazonaws.com/Y8h1EXfNasi8mTfCQWWNKY https://cassyni.com/events/R2yw8tEpg4BkxA1DAvzpyT/seminar/qa https://cassyni.com/slides/outline/R2yw8tEpg4BkxA1DAvzpyT https://cassyni.com/events/R2yw8tEpg4BkxA1DAvzpyT/abstract https://cassyni-user-files-prod.s3.amazonaws.com/M5afrJCvs4FTi9JD7DzR2W https://cassyni.com/events/R2yw8tEpg4BkxA1DAvzpyT?videoPreview=1 One hundred years of wheel shimmy: Why is it still dangerous?nohttps://cassyni.com/events/R2yw8tEpg4BkxA1DAvzpyT?videoPreview=12023-03-15T15:00:00+00:002585.0Nonlinear Dynamics, an International Journal of Nonlinear Dynamics and Chaos in Engineering SystemsShimmy is a hard-to-predict vibration phenomenon of towed rolling wheels. Although it appears with low probability, it may cause catastrophic accidents. Low order models of shimmying wheels with single contact point and Coulomb friction exhibit the fundamental phenomenology. Local and global dynamic analyses explore parameter regions with bi-stability, isola, chaotic and transient chaotic oscillations. If there is pneumatic tire on the wheel, a certain time delay effect becomes relevant in the nonlinear dynamics of the system. Experimentally detected micro-shimmy onset is explained by carrying out a non-smooth bifurcation analysis that is related to the nonlinear effect of partial slipping within the tire/ground contact region. ### Key Learning Objectives * **Single wheel shimmy is a dynamic contact paradigm** * **The rich shimmy dynamics originates from the unique combination of the nonlinearly constrained spatial motion of a rigid wheel and the nonlinear elastic contact "where the rubber meets the road”** * **The complex nonlinear phenomena of shimmying wheels are important for controlling new transportation devices like segways, unicycles, rollers, skateboards, snakeboards, powerslides, caster boards, hoverboards** * **The nonlinear dynamics of shimmy can induce low-probability accidents with conventional wheeled transportation devices.** ### Who Should Attend * **Mechanical engineers** * **Aerospace engineers** * **Researchers/scientists in mechanical sciences and dynamics** * **Research/Project managers** * **Heads of research divisions in mechanical design, dynamics, tribology** https://cassyni-user-files-prod.s3.amazonaws.com/M5afrJCvs4FTi9JD7DzR2W https://cassyni.com/events/3JTM6omjMupM9QivnqcAH3/seminar/qa https://cassyni.com/slides/outline/3JTM6omjMupM9QivnqcAH3 https://cassyni.com/events/3JTM6omjMupM9QivnqcAH3/abstract https://cassyni-user-files-prod.s3.amazonaws.com/GC5Qiu1Ye2u1A2U4W21xeJ https://cassyni.com/events/3JTM6omjMupM9QivnqcAH3?videoPreview=1 The Royal Society Biographical Memoirs: highlights and experiences as Editor-in-Chiefnohttps://cassyni.com/events/3JTM6omjMupM9QivnqcAH3?videoPreview=12023-04-12T15:00:00+00:003347.44Royal Society PublishingThe *Biographical Memoirs* series publishes extended scientific obituaries of Fellows of the Royal Society. These carefully researched and creatively written memoirs of eminent mathematical, physical, biological and medical scientists and engineers are often written by a close colleague or research collaborator. Each memoir is intended to provide an accessible overview of the subject’s scientific achievements, as well as shining a light on the very varied backgrounds of Fellows and the human side of scientific success. In this seminar, Editor-in-Chief Professor Malcolm Longair will speak about his experience of editing the memoirs since 2016 and talk about some of the highlights in the latest volume.https://cassyni-user-files-prod.s3.amazonaws.com/GC5Qiu1Ye2u1A2U4W21xeJ https://cassyni.com/events/ADXokNq5WKa8eDiWAHB6Rj/seminar/qa https://cassyni.com/slides/outline/ADXokNq5WKa8eDiWAHB6Rj https://cassyni.com/events/ADXokNq5WKa8eDiWAHB6Rj/abstract https://cassyni-user-files-prod.s3.amazonaws.com/7FNFFfWVH5aF46zSs6phiE https://cassyni.com/events/ADXokNq5WKa8eDiWAHB6Rj?videoPreview=1 AI 4 Health Ideathon - Final presentationsnohttps://cassyni.com/events/ADXokNq5WKa8eDiWAHB6Rj?videoPreview=12023-03-30T16:00:00+00:004554.56SisonkeBiotikJoin us for the live final idea pitches from the top 3 teams participating in our Ideathon! Each team will have 15min to present their idea and answer questions from our judges and audience. 1st, 2nd and 3rd place will be announced after this event with feedback from our judges. More information about the Ideathon can be found at https://www.sisonkebiotik.africa/events/ideathonhttps://cassyni-user-files-prod.s3.amazonaws.com/7FNFFfWVH5aF46zSs6phiE https://cassyni.com/slides/outline/P4PWx9eivDxzrSiyoy8tYu https://cassyni.com/events/P4PWx9eivDxzrSiyoy8tYu/abstract https://cassyni-user-files-prod.s3.amazonaws.com/PBYf9va4FTYpt4puGWa4ZU https://cassyni.com/events/P4PWx9eivDxzrSiyoy8tYu?videoPreview=1 Machine Learning for Fluid Dynamics: Patternsnohttps://cassyni.com/events/P4PWx9eivDxzrSiyoy8tYu?videoPreview=12020-11-27T12:00:00+00:001251.12Brunton LabThis video discusses how machine learning is currently being used to extract useful patterns and coherent structures in high-dimensional fluid dynamics.https://cassyni-user-files-prod.s3.amazonaws.com/PBYf9va4FTYpt4puGWa4ZU https://cassyni.com/slides/outline/HdFsSdXx6BsvTaUkD496ZT https://cassyni.com/events/HdFsSdXx6BsvTaUkD496ZT/abstract https://cassyni-user-files-prod.s3.amazonaws.com/YGFPAkLdpj9MkHePRuftnJ https://cassyni.com/events/HdFsSdXx6BsvTaUkD496ZT?videoPreview=1 Overview of Methodsnohttps://cassyni.com/events/HdFsSdXx6BsvTaUkD496ZT?videoPreview=12022-01-03T12:00:00+00:001296.52Brunton LabThis video introduces the variety of methods for model-based and model-free reinforcement learning, including: dynamic programming, value and policy iteration, Q-learning, deep RL, TD-learning, SARSA, policy gradient optimization, among others.https://cassyni-user-files-prod.s3.amazonaws.com/YGFPAkLdpj9MkHePRuftnJ https://cassyni.com/slides/outline/Dg535AMkaXSmfv24owZ3xZ https://cassyni.com/events/Dg535AMkaXSmfv24owZ3xZ/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Ctos4CMDKsFRAEfRZ2k7Je https://cassyni.com/events/Dg535AMkaXSmfv24owZ3xZ?videoPreview=1 Anthromes, CO2 and Terrestrial Carbon – Session 9 : How do we bring people & equity into C-cycle science?nohttps://cassyni.com/events/Dg535AMkaXSmfv24owZ3xZ?videoPreview=12023-03-30T14:50:00+00:001788.6The New Phytologist Foundation10:50 - 11:20 Stakeholder engagement to address concerns and opportunities related to the carbon cycle, Virgina Dale*https://cassyni-user-files-prod.s3.amazonaws.com/Ctos4CMDKsFRAEfRZ2k7Je https://cassyni.com/slides/outline/Cgmpyo4hhcLd1AC4hy5j9f https://cassyni.com/events/Cgmpyo4hhcLd1AC4hy5j9f/abstract https://cassyni-user-files-prod.s3.amazonaws.com/dGV6joHLEtXtza2abie3G https://cassyni.com/events/Cgmpyo4hhcLd1AC4hy5j9f?videoPreview=1 Bacterial Motility-From Physics To Human Healthnohttps://cassyni.com/events/Cgmpyo4hhcLd1AC4hy5j9f?videoPreview=12023-01-19T09:00:00+00:004319.72Journal of Biological PhysicsEvolving on planet Earth for billions of years, microbes have developed an ability to move in liquid or on moist surfaces. Flagellated bacteria can swim in water with the aid of helical shaped flagella. Each flagellum is driven by a rotary motor embedded at the bacterial cell wall. Besides swimming, many species of bacteria also display swarming motility, an impressive form of collective migration as a growing population of bacteria spreads over moist surfaces. The fundamental fluid mechanics and interfacial physics account for a rich variety of patterns expanding bacterial colonies develop, including fingerlike protrusions (Yang 2017), expanding wavefronts (Du 2012), and dynamic droplets (Ma 2021). Our ongoing study focuses on a particular species of bacteria, the Enterobacter sp. SM3, which is identified from murine hosts under conditions relevant to the human inflammable bowel disease (IBD). SM3 manifests strong swarming behavior, whereas its isogenic mutants isolated from healthy control animals do not swarm as strongly (De 2021). It is hoped that the study of swarming motility of SM3 may reveal its hidden benefit on disease amelioration. More broadly, new knowledge of bacterial swarming motility might lead to biomedical and environmental applications.https://cassyni-user-files-prod.s3.amazonaws.com/dGV6joHLEtXtza2abie3G https://cassyni.com/slides/outline/RXfAJCQEWsfamcziy37o9f https://cassyni.com/events/RXfAJCQEWsfamcziy37o9f/abstract https://cassyni-user-files-prod.s3.amazonaws.com/LxScAENk5ij7LRGoGsgR3t https://cassyni.com/events/RXfAJCQEWsfamcziy37o9f?videoPreview=1 Immunogenomic analysis of human brain metastases reveals diverse immune landscapes across genetically distinct tumorsnohttps://cassyni.com/events/RXfAJCQEWsfamcziy37o9f?videoPreview=12023-05-10T14:00:00+00:001138.04Cassyni SeminarsBrain metastases (BrMs) are the most common form of brain tumors in adults and frequently originate from lung and breast primary cancers. BrMs are associated with high mortality, emphasizing the need for more effective therapies. Genetic profiling of primary tumors is increasingly used as part of the effort to guide targeted therapies against BrMs, and immune-based strategies for the treatment of metastatic cancer are gaining momentum. However, the tumor immune microenvironment (TIME) of BrM is extremely heterogeneous, and whether specific genetic profiles are associated with distinct immune states remains unknown. Here, we perform an extensive characterization of the immunogenomic landscape of human BrMs by combining whole-exome/whole-genome sequencing, RNA sequencing of immune cell populations, flow cytometry, immunofluorescence staining, and tissue imaging analyses. This revealed unique TIME phenotypes in genetically distinct lung- and breast-BrMs, thereby enabling the development of personalized immunotherapies tailored by the genetic makeup of the tumors.https://cassyni-user-files-prod.s3.amazonaws.com/LxScAENk5ij7LRGoGsgR3t https://cassyni.com/events/WU9Cm2sUuTCcAii4yWpnso/seminar/qa https://cassyni.com/slides/outline/WU9Cm2sUuTCcAii4yWpnso https://cassyni.com/events/WU9Cm2sUuTCcAii4yWpnso/abstract https://cassyni-user-files-prod.s3.amazonaws.com/KTLkvYeVZdRV23LR7EFy7c https://cassyni.com/events/WU9Cm2sUuTCcAii4yWpnso?videoPreview=1 The Lens of Lived Experience: Music and Black Community in Segregated North Carolinanohttps://cassyni.com/events/WU9Cm2sUuTCcAii4yWpnso?videoPreview=12023-06-21T16:00:00+00:003573.72Lived Places PublishingWe invite you to a conversation with **Chris McAuley**, Black Studies Collection Editor at Lived Places Publishing (LPP) and **Gregory Freeland**, author of *[Music and Black Community in Segregated North Carolina](https://livedplacespublishing.com/book/isbn/9781915271211?utm_source=MB&utm_medium=web&utm_campaign=cassyni)*. They will discuss the pivotal role that music played in keeping a community together during one of the most legally segregated times in United States history. Southern black people survived racially motivated attacks, imprisonments, appropriations, enslavement, and exploitation all the while continuing to struggle and survive those injustices. Through the lens of Dr. Freeland's experiences during segregation in North Carolina he found that music was vital to community togetherness and spiritual well-being and that music brought the community into positive spaces that fostered survival, both intentionally, through activism, and naturally, through the effect of music’s all-encompassing uniting presence. https://cassyni-user-files-prod.s3.amazonaws.com/KTLkvYeVZdRV23LR7EFy7c https://cassyni.com/events/6GNbVYAmQ24i12xE3jXVTT/seminar/qa https://cassyni.com/slides/outline/6GNbVYAmQ24i12xE3jXVTT https://cassyni.com/events/6GNbVYAmQ24i12xE3jXVTT/abstract https://cassyni-user-files-prod.s3.amazonaws.com/DCME9gPGLmajYq7YeEqrei https://cassyni.com/events/6GNbVYAmQ24i12xE3jXVTT?videoPreview=1 Turbomachinerynohttps://cassyni.com/events/6GNbVYAmQ24i12xE3jXVTT?videoPreview=12023-06-14T10:00:00+00:005841.72NEKTAR++Combustion modelling methods are implemented into the Nektar++ framework to create a reactive flow solver capable of accurately modelling combustion flow regimes at low Mach numbers. The study investigates how the high-order resolution of a mixing flow field translates to modelling of turbulent diffusion flames, in regard to both cost and accuracy. First, a non-reacting pseudo-compressible flow solver has been developed based on the Incompressible Navier-Stokes code, using a low Mach variable density approach able to simulate mixing between fuel and oxidizer streams. For modelling of reactive flow, results of a 1D flamelet generated manifold (FGM) formulation dependant on mixture fraction, Z, are tabulated and coupled into the solving process. Validations are presented with turbulent cold flow mixing and canonical reacting flow cases, including combustor relevant geometry such as Sandia Propane-Jet flow and Sandia Piloted CH4/Air Flames. Implicit Large Eddy Simulations are nowadays becoming possible in an industrial setting, particularly by deploying more efficient high-order codes such as Nektar++. Turbomachinery companies are one of the realms where this is of particular interest to promote the understanding of complicated and varied turbulent phenomena appearing throughout aircraft engines. One of the components of interest are the high pressure turbines sitting just downstream of the combustor. In this work, the LS89 geometry was considered: this case was studied in a linear cascade configuration in the experimental campaign carried out in the early 1990s at the von Karman institute [1]. In this talk, two flow conditions will be presented: a low and a high pressure ratio. Only in the latter case a shock will appear, with slightly different meshing requirements being necessary. A complete 2D study will be shown to demonstrate the know-how gained in setting-up and running these cases. In particular, a considerable effort was made to match the experimental boundary conditions by using different strategies. A comparison of the final results with polynomial order 4 with those provided by the Reynolds-Averaged-Navier-Stokes solver SU2 and the experiments will show the benefit of using Nektar++. Considerations in terms of meshing requirements to reach Direct Numerical Simulations will also be discussed. Finally, three-dimensional results and analysis will be presented for the low Mach number case with a more in-depth discussion of the flow physics. Advances in computer architecture, parallel programming and high-order methods in computational fluid dynamics have enabled Direct Numerical Simulation (DNS) in turbomachinery components in the last decade. High-order frameworks such as Nektar++ has become very attractive since the industrial sector strives to increase fidelity and accuracy during the design process at low computation cost. In this talk, Implicit Large Eddy Simulations (iLES) of two turbomachinery components were investigated using Nektar++ framework. First, compressibility effects are studied in an engine intake pressure distribution at high Reynolds numbers in absence of transonic effects and under strong adverse pressure gradients on a flat plate. After that, preliminary results of the well known T106A Low Pressure Turbine (LPT) will also be discussed. In addition, a new functionality was implemented in the nektar++ framework to deal with local regions where additional mesh refinement is required, e.g. flow separation at the boundary layer, without needing to redesign the mesh. Thus, with this functionality, it is possible to locally change the polynomial order (expansion) of the selected elements for each composite in the mesh. This functionality was designed not only to deal with the flow physics and avoid re-meshing but also to save computational resources in expensive numerical simulations as found in industrial applications. So that, it is not necessary to change the expansion in the whole composite anymore if only a small part of the domain needs refinement.https://cassyni-user-files-prod.s3.amazonaws.com/DCME9gPGLmajYq7YeEqrei https://cassyni.com/slides/outline/G9LgRD7GBB92rYxFZJHrbP https://cassyni.com/events/G9LgRD7GBB92rYxFZJHrbP/abstract https://cassyni-user-files-prod.s3.amazonaws.com/DdheFbfQKz996GCqHiZUpW https://cassyni.com/events/G9LgRD7GBB92rYxFZJHrbP?videoPreview=1 Session 9 (Part 1) - Rejuvenation, reproduction, and regeneration: resetting the plant juvenility clocknohttps://cassyni.com/events/G9LgRD7GBB92rYxFZJHrbP?videoPreview=12023-07-04T08:00:00+00:001824.92New Phytologist Foundation Multicellular organisms undergo several developmental transitions during their life cycles. In plants, the juvenile phase differs from the adult phase in terms of floral competence and morphological and anatomical traits in successive leaves. In this talk, I will first demonstrate that the juvenile phase is essential for plant reproductive success and that a high level of microRNA156 (miR156) and cell quiescence are two key factors for maintaining juvenility in plants. I will then discuss how the plant juvenility clock is reset through various pathways. Specifically, I will illustrate how plants develop a robust mechanism to ensure accurate restoration of the juvenile phase in each generation, and how this similar principle is also adopted for the reset of juvenility during de novo shoot regeneration.https://cassyni-user-files-prod.s3.amazonaws.com/DdheFbfQKz996GCqHiZUpW https://cassyni.com/slides/outline/AiD2ugzVM93xTgi1xPJ4bw https://cassyni.com/events/AiD2ugzVM93xTgi1xPJ4bw/abstract https://cassyni-user-files-prod.s3.amazonaws.com/MH244GXDXHocNtdh2HjBqg https://cassyni.com/events/AiD2ugzVM93xTgi1xPJ4bw?videoPreview=1 Research Discovery & Organization- Part 1nohttps://cassyni.com/events/AiD2ugzVM93xTgi1xPJ4bw?videoPreview=12023-06-27T18:30:00+00:003055.28SCIWRITERNo abstracthttps://cassyni-user-files-prod.s3.amazonaws.com/MH244GXDXHocNtdh2HjBqg https://cassyni.com/slides/outline/XTU2y2gRBjEUzFpKKtqtYV https://cassyni.com/events/XTU2y2gRBjEUzFpKKtqtYV/abstract https://cassyni-user-files-prod.s3.amazonaws.com/KEz4v4iXAW97PefkNkGxzJ https://cassyni.com/events/XTU2y2gRBjEUzFpKKtqtYV?videoPreview=1 Approximate Logic Synthesis: a New Dimension in the Synthesis of Digital Circuitsnohttps://cassyni.com/events/XTU2y2gRBjEUzFpKKtqtYV?videoPreview=12023-09-12T09:00:00+00:001750.52HiPEDS CentreAs energy efficiency becomes a crucial concern in every kind of digital application, Approximate Computing gains popularity as a potential answer to this ever-growing energy quest. Approximate Computing is a design paradigm which postulates the use of approximate computation, as opposed to exact, in order to significantly improve energy consumption and resources employment (such as electric power, or circuit area) at the expense of a slight reduction in output accuracy and hence of quality of result. In this talk I will introduce Approximate Logic Synthesis, the process of automatically deriving the functionality of approximate circuits, given their exact counterparts, while controlling the entailed error. I will presents the panorama of state of the art algorithms used to this purpose, and then I will introduce a methodology lately developed in my own group and based on a SAT formulation. https://cassyni-user-files-prod.s3.amazonaws.com/KEz4v4iXAW97PefkNkGxzJ https://cassyni.com/events/Q3mbPQVS1DrRKNkUZgpL3P/seminar/qa https://cassyni.com/slides/outline/Q3mbPQVS1DrRKNkUZgpL3P https://cassyni.com/events/Q3mbPQVS1DrRKNkUZgpL3P/abstract https://cassyni-user-files-prod.s3.amazonaws.com/DqznkegoZ7GYDLKH5iQTZG https://cassyni.com/events/Q3mbPQVS1DrRKNkUZgpL3P?videoPreview=1 Creating the tools to conserve wildlifenohttps://cassyni.com/events/Q3mbPQVS1DrRKNkUZgpL3P?videoPreview=12023-10-24T10:00:00+00:003405.44Royal Society PublishingThe recent increase in public and academic interest in preserving biodiversity has led to the growth of the field of conservation technology. Conservation technology involves the construction of technology and tools and interfacing them to aid in the conservation of wildlife through collaborations or technology interventions. Creating the tools to conserve both fauna and flora is incredibly challenging and can be toxic if not approached with specific ideas in mind. In this talk, I will present some foundational framework for developing conservation tools (CT) based on human-wildlife interaction and human-wildlife-centred design. This will be followed by five case studies ranging in complexity from cat collars to machine learning and game theory methodologies. Conservation technology not only has the potential to benefit biodiversity but also has broader impacts on fields such as sustainability and environmental protection. By using innovative technologies to address conservation challenges, we can find more effective and efficient solutions to protect and preserve our planet’s resources.https://cassyni-user-files-prod.s3.amazonaws.com/DqznkegoZ7GYDLKH5iQTZG https://cassyni.com/events/7kNerr97X7aQe33zCDfZJM/abstract https://cassyni-user-files-prod.s3.amazonaws.com/4nRCBJkphs5c5BVT7yUoAe https://cassyni.com/events/4HqRY4cSSuhmcLkRYZHbmX/seminar/qa https://cassyni.com/slides/outline/4HqRY4cSSuhmcLkRYZHbmX https://cassyni.com/events/4HqRY4cSSuhmcLkRYZHbmX/abstract https://cassyni-user-files-prod.s3.amazonaws.com/CZg5849gp95HzeCs5kytoQ https://cassyni.com/events/4HqRY4cSSuhmcLkRYZHbmX?videoPreview=1 Morphisms between Aristotelian Diagramsnohttps://cassyni.com/events/4HqRY4cSSuhmcLkRYZHbmX?videoPreview=12023-11-15T15:00:00+00:004382.92Logica UniversalisIn logical geometry, Aristotelian diagrams are studied in a precise and systematic way. Although there has recently been a good amount of progress in logical geometry, it is still unknown which underlying mathematical framework is best suited for formalizing the study of these diagrams. Hence, in this paper, the main aim is to formulate such a framework, using the powerful language of category theory. We build multiple categories, which all have Aristotelian diagrams as their objects, while having different kinds of morphisms between these diagrams. The categories developed here are assessed according to their ability to generalize previous work from logical geometry as well as their interesting category-theoretical properties. According to these evaluations, the most promising category has as its morphisms those functions on fragments that increase in informativity on both the opposition and implication relations. Focusing on this category can significantly increase the effectiveness of further research in logical geometry.https://cassyni-user-files-prod.s3.amazonaws.com/CZg5849gp95HzeCs5kytoQ https://cassyni.com/slides/outline/QYSpYieqr3LF8qjzMnwJDb https://cassyni.com/events/QYSpYieqr3LF8qjzMnwJDb/abstract https://cassyni-user-files-prod.s3.amazonaws.com/JdZnD2NXFjRCzxSQKc6EQW https://cassyni.com/events/QYSpYieqr3LF8qjzMnwJDb?videoPreview=1 The surprising physics of Arctic Ocean vertical heat transportnohttps://cassyni.com/events/QYSpYieqr3LF8qjzMnwJDb?videoPreview=12023-04-27T12:00:00+00:002188.64Leeds Institute for Fluid DynamicsNo abstracthttps://cassyni-user-files-prod.s3.amazonaws.com/JdZnD2NXFjRCzxSQKc6EQW https://cassyni.com/slides/outline/H8ikrTwyGB2jNoZ5odKfmX https://cassyni.com/events/H8ikrTwyGB2jNoZ5odKfmX/abstract https://cassyni-user-files-prod.s3.amazonaws.com/2mbqx58cY4gGb749nP42zS https://cassyni.com/events/H8ikrTwyGB2jNoZ5odKfmX?videoPreview=1 3D quantitative-amplified Magnetic Resonance Imaging (3D q-aMRI)nohttps://cassyni.com/events/H8ikrTwyGB2jNoZ5odKfmX?videoPreview=12023-12-12T03:00:00+00:003520.52The Auckland Bioengineering InstituteAmplified Magnetic Resonance Imaging (aMRI) is a pulsatile brain motion visualization method that delivers ‘videos’ with high contrast and temporal resolution. aMRI has been shown to be a promising tool in various neurological disorders. However, aMRI currently lacks the ability to quantify the sub-voxel motion field in physical units. In this talk I will introduce out new quantitative-aMRI (q-aMRI) algorithm, which quantifies the sub-voxel motion of the 3D aMRI. https://cassyni-user-files-prod.s3.amazonaws.com/2mbqx58cY4gGb749nP42zS https://cassyni.com/slides/outline/T1gqn8tU3L74EKZ7KC62uT https://cassyni.com/events/T1gqn8tU3L74EKZ7KC62uT/abstract https://cassyni-user-files-prod.s3.amazonaws.com/3L3pAEpTStRJuxa2Ld7JG6 https://cassyni.com/events/T1gqn8tU3L74EKZ7KC62uT?videoPreview=1 Precision medicine in the communitynohttps://cassyni.com/events/T1gqn8tU3L74EKZ7KC62uT?videoPreview=12023-10-04T11:00:00+00:003643.56Cambridge PrismsScope: * Defining Precision Medicine across disciplines and industries * Preventive Medicine * Digital healthcare * Public understanding and engagementhttps://cassyni-user-files-prod.s3.amazonaws.com/3L3pAEpTStRJuxa2Ld7JG6 https://cassyni.com/slides/outline/5mornk4uAeHk6ZZwSdstkd https://cassyni.com/events/5mornk4uAeHk6ZZwSdstkd/abstract https://cassyni-user-files-prod.s3.amazonaws.com/6DWhRUCjcc7zjUdVeYpEsG https://cassyni.com/events/5mornk4uAeHk6ZZwSdstkd?videoPreview=1 Time-based sampling: Theory and an application to video reconstruction from eventsnohttps://cassyni.com/events/5mornk4uAeHk6ZZwSdstkd?videoPreview=12024-02-08T11:30:00+00:003060.28Journal on Image and Video ProcessingTraditional signal processing is based on the idea that an analogue waveform should be converted in digital form by recording its amplitude information at specific time instants. Nearly all data acquisition, processing and communication methods have progressed by relying on this fundamental sampling paradigm. Interestingly, we know that the brain operates differently and represents signals using networks of spiking neurons where the timing of the spikes encodes the signal's information. This form of processing by spikes is more efficient and is inspiring a new generation of event-based audio-visual sensing and processing architectures. In this talk, we investigate time encoding as an alternative method to classical sampling, and address the problem of reconstructing classes of sparse non-bandlimited signals from time-based samples. We consider a sampling mechanism based on first filtering the input, before obtaining the timing information using a time encoding machine. Leveraging specific properties of these filters, we derive sufficient conditions and propose novel algorithms for perfect reconstruction of classes of sparse signals. We then extend our analysis to multi-dimensional signals and introduce a deep neural networks for the reconstruction of intensity videos from events generated by event-driven cameras. The network is obtained by embedding prior-models in its architecture. We show that this approach leads to simple and yet effective neural networks. https://cassyni-user-files-prod.s3.amazonaws.com/6DWhRUCjcc7zjUdVeYpEsG https://cassyni.com/events/2KGdTxYE6SR74sGNnyVwDo/seminar/qa https://cassyni.com/slides/outline/2KGdTxYE6SR74sGNnyVwDo https://cassyni.com/events/2KGdTxYE6SR74sGNnyVwDo/abstract https://cassyni-user-files-prod.s3.amazonaws.com/VU4oT96c1kmc5PeypdCNSi https://cassyni.com/events/2KGdTxYE6SR74sGNnyVwDo?videoPreview=1 Regulation of Chemical Processes by Phase Separationnohttps://cassyni.com/events/2KGdTxYE6SR74sGNnyVwDo?videoPreview=12024-01-18T15:00:00+00:005306.28Journal of Biological PhysicsPhase-separated liquid condensates can spatially organize and thereby regulate chemical processes. The physicochemical mechanisms underlying such regulation remain elusive as intra-molecular interactions give rise to a coupling between diffusion and chemical reactions at non-dilute conditions. In this seminar, I will first show that the concepts of non-equilibrium thermodynamics can be applied to phase separation in living cells. Moreover, I will derive a theoretical framework that governs the coupling between the phase separation of molecular components and their chemical reactions. When components diffusive fast compared to chemical reactions, a powerful framework can be derived to understand chemical kinetics in non-dilute systems where chemical trajectories can be drawn in thermodynamics phase diagrams. This versatile framework can be applied to various chemical processes in systems biology and biological cells. It can also be used to experimentally quantify how condensed phases alter chemical processes and thus help unravel how biomolecular condensates regulate biochemistry in living cells.https://cassyni-user-files-prod.s3.amazonaws.com/VU4oT96c1kmc5PeypdCNSi https://cassyni.com/events/J7xiiaDFLNHX73WjAfhZsj/seminar/qa https://cassyni.com/slides/outline/J7xiiaDFLNHX73WjAfhZsj https://cassyni.com/events/J7xiiaDFLNHX73WjAfhZsj/abstract https://cassyni-user-files-prod.s3.amazonaws.com/VmPG3TfDZTeEhV9MByPxSA https://cassyni.com/events/J7xiiaDFLNHX73WjAfhZsj?videoPreview=1 Modelling ternary electrolyte systems for Na-ion batteriesnohttps://cassyni.com/events/J7xiiaDFLNHX73WjAfhZsj?videoPreview=12023-09-12T13:00:00+00:003144.08Electrochimica ActaTo realize high-performing Na-ion batteries, specific electrolyte systems needs to be developed that are tailored for this specific battery chemistry and its electrode materials. This has shown challenging, and especially the interphase layer formation and stability appears different in Na-ion batteries than for Li-ion battery counterparts. In this context, it is of interest to both develop alternative electrolyte systems, and to understand the fundamental chemical processes better. This presentation will focus on both these aspects, where ternary electrolyte systems (comprising Na-salt, ionic liquids and conductive polymers) are been investigated using Molecular Dynamics (MD) simulation techniques. MD has shown to be a powerful tool to explore the atomic-scale structure-dynamic properties of electrolytes. In particular, we will discuss our latest findings on NaTSFI- and NaFSI-based electrolytes comprising poly(ethylene oxide) (PEO) and ionic liquids of N-methyl-N-propylpyrrolidinium (Pyr13) and the respective anions for different concentrations and temperatures. These MD simulations unveil an interplay between the coordination chemistry and the dynamic properties in these ternary electrolytes, and how the coordination strength controls the conductive properties.https://cassyni-user-files-prod.s3.amazonaws.com/VmPG3TfDZTeEhV9MByPxSA https://cassyni.com/slides/outline/LbCjwzSsXf41TyzHiMcCbf https://cassyni.com/events/LbCjwzSsXf41TyzHiMcCbf/abstract https://cassyni-user-files-prod.s3.amazonaws.com/EER7PzJ5KmshVymh2yn4qk https://cassyni.com/events/LbCjwzSsXf41TyzHiMcCbf?videoPreview=1 Developing a theory of change for academic sciencenohttps://cassyni.com/events/LbCjwzSsXf41TyzHiMcCbf?videoPreview=12023-01-09T17:00:00+00:003526.48DeSci FoundationMany of the working practices and culture of academia are ancient – universities have existed for well over a thousand years, the concept of the academic journal is 400 years old, and the notion of the 19th Century independent scholar still encapsulates the implicit model of what it is to be an academic. The result is considerable inertia, and (unconscious) conservatism when it comes to changing how we work in academia. To move academia, and academic practice, into the 21st Century will require coordinated action across multiple elements of the sector. I will discuss current efforts to achieve this.https://cassyni-user-files-prod.s3.amazonaws.com/EER7PzJ5KmshVymh2yn4qk https://cassyni.com/events/Vyc6AsHW5SMR5wnQa61N5s/seminar/qa https://cassyni.com/slides/outline/Vyc6AsHW5SMR5wnQa61N5s https://cassyni.com/events/Vyc6AsHW5SMR5wnQa61N5s/abstract https://cassyni-user-files-prod.s3.amazonaws.com/TcrcFYXNSKi8htkQ35Uovn https://cassyni.com/events/Vyc6AsHW5SMR5wnQa61N5s?videoPreview=1 Dust in the (Solar) Wind: Investigations of Orbital Debris and Asteroid Evolutionnohttps://cassyni.com/events/Vyc6AsHW5SMR5wnQa61N5s?videoPreview=12024-07-16T14:30:00+00:003441.08AIAA JournalThe interaction of charged particles with the local plasma environment is of interest in a variety of space applications. This talk will focus on two specific applications: 1. the design of new technologies to detect orbital debris and 2. the evolution of asteroid surfaces. Small (sub-cm) orbital debris poses a serious hazard to functional spacecraft, but is very difficult detect (and impossible to track) using conventional technologies. Our simulations predict that many of these debris objects will produce solitons in the ionospheric plasma environment. We will present the characteristics of the debris that are predicted to produce solitons and the characteristics of the resulting solitons. Detection of debris-produced solitons may provide a new technique to monitor the highly uncertain sub-cm debris environment. Our second topic concerns the removal of small particles from the surfaces of asteroids. The regolith of many small asteroids is coarse compared to other solar system bodies like the Moon. It has been hypothesized that small regolith particles may be removed from asteroids due to the interaction of the charged particles with the local plasma environment. We will present predictions of the sizes of particles that can be lofted from the asteroid Bennu and the subsequent trajectories (including escape) of those particles. We will also show experimental observations of the electrostatic lofting of clumps of regolith particles. Electrostatic lofting, combined with solar radiation pressure, may be an active loss mechanism on asteroids. https://cassyni-user-files-prod.s3.amazonaws.com/TcrcFYXNSKi8htkQ35Uovn https://cassyni.com/slides/outline/UzE1jcSnzSTzdKLknCwFpZ https://cassyni.com/events/UzE1jcSnzSTzdKLknCwFpZ/abstract https://cassyni-user-files-prod.s3.amazonaws.com/4oEEPbY7SuTQgABu1DXkhL https://cassyni.com/events/UzE1jcSnzSTzdKLknCwFpZ?videoPreview=1 Collisional Contact Charging in Granular Materialsnohttps://cassyni.com/events/UzE1jcSnzSTzdKLknCwFpZ?videoPreview=12021-01-05T12:00:00+00:003819.32Granular MatterCollisional contact charging of sub-millimeter particles and the resulting clustering is important in circumstances ranging from the earliest stages of planet formation to aggregation of airborne pollutants to industrial powder processing. Even in systems comprised of grains of identical dielectric material, contact charging can generate large amounts of net positive or negative charge on individual particles, resulting in long-range electrostatic forces. Remarkably, rather fundamental aspects of contact charging, such as the type of the charge carriers or the nature of the charge transfer mechanism are still under debate. This webinar focuses on recent work where collision events between individual particles are tracked with high-speed video and the charge on single particles can be extracted. In freely falling granular streams we observe collide-and-capture events between charged particles and particle-by-particle aggregation into clusters. Size-dependent contact charging is found to produce a variety of charge-stabilized “granular molecules”, whose configurations can be modeled by taking many-body dielectric polarization effects into account. I will also introduce a new approach, based on ultrasonic levitation, for studying contact charging where the very same particles can be forced to undergo multiple head-on collisions. This method allows for measurements under a wide range of environmental conditions as well as applying an electric field, and its exquisite sensitivity makes it possible to determine the net charge transferred in a single contact event.https://cassyni-user-files-prod.s3.amazonaws.com/4oEEPbY7SuTQgABu1DXkhL https://cassyni.com/slides/outline/TzvoeF9k7XMqxZWkgETw1f https://cassyni.com/events/TzvoeF9k7XMqxZWkgETw1f/abstract https://cassyni-user-files-prod.s3.amazonaws.com/LfZVNMRVfL6362ncd79U7Q https://cassyni.com/events/TzvoeF9k7XMqxZWkgETw1f?videoPreview=1 Deep learning for inverse problems in imagingnohttps://cassyni.com/events/TzvoeF9k7XMqxZWkgETw1f?videoPreview=12023-06-01T10:30:00+00:003164.96Journal on Image and Video ProcessingDeep learning has significantly advanced several areas of imaging, from image analysis tasks such as classification and segmentation to image restoration tasks. Besides being able to produce photorealistic images, generative architectures such as GANs and diffusion models have turned out to be very useful for solving inverse problems, providing powerful priors that can be used even with lack of ground truth data, or lack of training data at all. This talk will focus on recent advances in deep models for restoration, touching on aspects such as perception, complexity and priors. I will cover models for supervised, self-supervised, unsupervised and one-shot restoration, in the single- and multi-image case, as well as the generation of multiple ""good"" solutions that are consistent with the observed data. I will show examples of models learning non-local relationships in the data, along with applications to a variety of data types including optical/radar satellite images and point clouds. I will discuss the implications of these methods on accuracy, perceptual quality and complexity, and I will discuss multimodality as a way to further improve image restoration accuracy.https://cassyni-user-files-prod.s3.amazonaws.com/LfZVNMRVfL6362ncd79U7Q https://cassyni.com/slides/outline/6m3perLBEqYXpoXaogFnrq https://cassyni.com/events/6m3perLBEqYXpoXaogFnrq/abstract https://cassyni-user-files-prod.s3.amazonaws.com/ENDAgkNtrfFyjY6dNjSm6e https://cassyni.com/events/6m3perLBEqYXpoXaogFnrq?videoPreview=1 Detect and Defense Against Adversarial Examples in Deep Learningnohttps://cassyni.com/events/6m3perLBEqYXpoXaogFnrq?videoPreview=12022-11-03T12:30:00+00:002767.48Journal on Image and Video ProcessingDespite the enormous performance of Deep Neural Networks (DNNs), recent studies have shown their vulnerability to Adversarial Examples (AEs), i.e., carefully perturbed inputs designed to fool the targeted DNN. The literature is rich with many effective attacks to craft such AEs. Meanwhile, many defense strategies have been developed to mitigate this vulnerability. However, this latter showed their effectiveness against specific attacks and does not generalize well to different attacks. This talk presents a framework for defending the DNN classifier against adversarial samples. The proposed method includes a separate detector and a denoising block. The detector aims to detect AEs by characterizing them through natural scene statistics (NSS), where we demonstrate that the presence of adversarial perturbations alters these statistical features. The denoiser is based on Block Matching 3D (BM3D) filter fed by a threshold estimated by a Convolutional Neural Network (CNN) to project back the samples detected as AEs into their data manifold. We conduct a complete evaluation on three standard datasets: MNIST, CIFAR-10, and Tiny-ImageNet, compared with state-of-the-art defenses. Our experimental results have shown that the proposed detector achieves a high detection accuracy while providing a low false positive accuracy. Additionally, we outperform the state-of-the-art-defense techniques by improving the robustness of DNN’s.https://cassyni-user-files-prod.s3.amazonaws.com/ENDAgkNtrfFyjY6dNjSm6e https://cassyni.com/slides/outline/7FhRhXyhgJ6apa4UQ7Yb89 https://cassyni.com/events/7FhRhXyhgJ6apa4UQ7Yb89/abstract https://cassyni-user-files-prod.s3.amazonaws.com/5r2VdxU6HWhsoWtwMJ37gJ https://cassyni.com/events/7FhRhXyhgJ6apa4UQ7Yb89?videoPreview=1 An Overview of Touchless 2D Fingerprint Recognitionnohttps://cassyni.com/events/7FhRhXyhgJ6apa4UQ7Yb89?videoPreview=12020-12-03T12:30:00+00:003544.36Journal on Image and Video ProcessingNo abstracthttps://cassyni-user-files-prod.s3.amazonaws.com/5r2VdxU6HWhsoWtwMJ37gJ https://cassyni.com/slides/outline/EAmtM733phrNKP43mZ7XGq https://cassyni.com/events/EAmtM733phrNKP43mZ7XGq/abstract https://cassyni-user-files-prod.s3.amazonaws.com/NGB9woxe2smyZ1WMGwxH3L https://cassyni.com/events/EAmtM733phrNKP43mZ7XGq?videoPreview=1 Hilbert 𝐶∗ -module independencenohttps://cassyni.com/events/EAmtM733phrNKP43mZ7XGq?videoPreview=12023-06-29T15:00:00+00:003443.36Journal of Mathematical SciencesIn this talk, we review some kinds of independence in setting of operator algebras. We introduce the notion of Hilbert 𝐶∗-module independence and show that it is a natural generalization of the notion of 𝐶∗-independence. Furthermore, we demonstrate that even in the case of 𝐶∗-algebras this concept of independence is new and has a nice characterization in terms of Hahn-Banach type extensions. This talk is based on a joint work with R. Eskandari, J. Hamhalter, and V. M. Manuilov.https://cassyni-user-files-prod.s3.amazonaws.com/NGB9woxe2smyZ1WMGwxH3L https://cassyni.com/slides/outline/BhXs7goRdR5qHDpGJmKAGd https://cassyni.com/events/BhXs7goRdR5qHDpGJmKAGd/abstract https://cassyni-user-files-prod.s3.amazonaws.com/WSKLvFyF2PX3TGGgVoxjsk https://cassyni.com/events/BhXs7goRdR5qHDpGJmKAGd?videoPreview=1 Advancing personalized prognosis in atypical and anaplastic meningiomas through interpretable machine learning modelsnohttps://cassyni.com/events/BhXs7goRdR5qHDpGJmKAGd?videoPreview=12023-11-06T21:00:00+00:001672.16Journal of Neuro-OncologyJoin the Journal Of Neuro-Oncology Editor-In-Chief, Dr. Jason Sheehan, and Associate Editor, Dr. Randy D'Amico, for a conversation with Dr. Raj Shrivastava, Dr. Mert Karabacak, and Dr. Konstantinos Margetis on their recent publication on advancing personalized prognosis in atypical and anaplastic meningiomas through interpretable machine learning models.https://cassyni-user-files-prod.s3.amazonaws.com/WSKLvFyF2PX3TGGgVoxjsk https://cassyni.com/slides/outline/K7HYva2BceKPvH38ZD7LKF https://cassyni.com/events/K7HYva2BceKPvH38ZD7LKF/abstract https://cassyni-user-files-prod.s3.amazonaws.com/FVDHYnVidX9vwRTmE6wsfU https://cassyni.com/events/K7HYva2BceKPvH38ZD7LKF?videoPreview=1 Introducing Transformative Plant Biotechnology: Transgene-free CRISPR-edited plants through grafting by RNA translocationnohttps://cassyni.com/events/K7HYva2BceKPvH38ZD7LKF?videoPreview=12023-09-22T08:30:00+00:00805.24The New Phytologist FoundationGeneration of stable gene-edited plant lines using CRISPR-Cas9 requires a lengthy process of outcrossing to eliminate CRISPR–Cas9-associated sequences and produce transgene-free lines. We have addressed this issue by designing fusions of Cas9 and guide RNA transcripts to tRNA-like sequence motifs that move RNAs from transgenic rootstocks to grafted wild-type shoots (scions) and achieve heritable gene editing, as demonstrated in wild-type Arabidopsis thaliana and Brassica rapa. The graft-mobile gene editing system enables the production of transgene-free offspring in one generation without the need for transgene elimination, culture recovery and selection, or use of viral editing vectors.https://cassyni-user-files-prod.s3.amazonaws.com/FVDHYnVidX9vwRTmE6wsfU https://cassyni.com/events/8F5W8npQmHz1HCW8BzchPT/abstract https://cassyni-user-files-prod.s3.amazonaws.com/QfhP5Tpobbq698JnUfY1pa https://cassyni.com/slides/outline/UVc2oZK9xLqfn2WGULauBs https://cassyni.com/events/UVc2oZK9xLqfn2WGULauBs/abstract https://cassyni-user-files-prod.s3.amazonaws.com/MxQmjMUfvF4Jdr7FWYnY3x https://cassyni.com/events/UVc2oZK9xLqfn2WGULauBs?videoPreview=1 HVDC Transmission Technologies for Offshore Wind Power Plantsnohttps://cassyni.com/events/UVc2oZK9xLqfn2WGULauBs?videoPreview=12021-06-28T12:00:00+00:003437.6Discover Applied SciencesThe talk will discuss various offshore wind power plants (OWPPs), their power transmission options, and OWPP configurations from a power electronics converter's point of view. It will further outline grid requirements for OWPP and how to satisfy any such requirements. Furthermore, it will discuss various converter topologies options for OWPP, and their challenges, leading to potential solutions and opportunities.https://cassyni-user-files-prod.s3.amazonaws.com/MxQmjMUfvF4Jdr7FWYnY3x https://cassyni.com/slides/outline/9iy53ajDGwoAjkLDZBXViu https://cassyni.com/events/9iy53ajDGwoAjkLDZBXViu/abstract https://cassyni-user-files-prod.s3.amazonaws.com/UQ3QcdmQbBawyWLMLSk4RU https://cassyni.com/events/9iy53ajDGwoAjkLDZBXViu?videoPreview=1 Thin-film flows over slippery substratesnohttps://cassyni.com/events/9iy53ajDGwoAjkLDZBXViu?videoPreview=12023-12-06T15:30:00+00:002900.92Leeds Institute for Fluid DynamicsIn various settings in nature and industry, certain types of substrates promote increased fluid flow through sliding. Large-scale examples include the flow of ice sheets, such as that of Greenland and Antarctica, over bedrock lubricated by a layer of subglacial till. Small-scale examples include the lotus leaf and fabricated hydrophobic surfaces, which are of use for various industrial applications, from microfluidics and flow delivery in the pharmaceutical and biotechnology industries, to drag reduction applications in the aeronautics and maritime industries, for example. What makes these types of surfaces slippery is their microstructure, which cushions the flow from below, promoting slip. This talk goes through the development of a novel theoretical and experimental framework for generating slip underneath viscous fluids experimentally. We build into it the freedom to adjust slip, as desired, for large-scale fluid-mechanical experiments motivated by environmental and industrial phenomena in which basal sliding is important. We base our framework on an analogy to classical hydrophobic surfaces and consider a range of substrates, including those that are lubricated from below, those that are deformable and those that are structured, consisting of a periodic sequence of two-dimensional, fluid-filled cavities, each giving rise to macroscopic sliding laws. We illustrate these theoretical results by means of a series of fluid-mechanical experiments.https://cassyni-user-files-prod.s3.amazonaws.com/UQ3QcdmQbBawyWLMLSk4RU https://cassyni.com/events/3JbTfxMANiSyt6nnBWuhfK/seminar/qa https://cassyni.com/slides/outline/3JbTfxMANiSyt6nnBWuhfK https://cassyni.com/events/3JbTfxMANiSyt6nnBWuhfK/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Bd5a3aGwaYn41fj3shCMpr https://cassyni.com/events/3JbTfxMANiSyt6nnBWuhfK?videoPreview=1 Increasing ambient temperatures trigger shifts in activity patterns and temporal partitioning in a large carnivore guildnohttps://cassyni.com/events/3JbTfxMANiSyt6nnBWuhfK?videoPreview=12024-04-10T16:00:00+00:002902.48Royal Society PublishingShifts in species’ interactions are implicated as an important proximate cause underpinning climate-change-related extinction. However, there is little empirical evidence on the pathways through which climate conditions, such as ambient temperature, impact community dynamics. The timing of activities is a widespread behavioural adaptation to environmental variability, and temporal partitioning is a key mechanism that facilitates coexistence, especially within large carnivore communities. We investigated temperature impacts on community dynamics through its influence on the diel activity of, and temporal partitioning amongst, four sympatric species of African large carnivores: lions (Panthera leo), leopards (Panthera pardus), cheetahs (Acinonyx jubatus) and African wild dogs (Lycaon pictus). Activity of all species was shaped by a combination of light availability and temperature, with most species becoming more nocturnal and decreasing activity levels with increasing temperatures. A nocturnal shift was most pronounced in cheetahs, the most diurnal species during median temperatures. This shift increased temporal overlap between cheetahs and other carnivore species by up to 15.92%, highlighting the importance of considering the responses of interacting sympatric species when inferring climate impacts on ecosystems. Our study provides evidence that temperature can significantly affect temporal partitioning within a carnivore guild by generating asymmetrical behavioural responses amongst functionally similar species.https://cassyni-user-files-prod.s3.amazonaws.com/Bd5a3aGwaYn41fj3shCMpr https://cassyni.com/slides/outline/N5CoKJRDekZkmuGRp72fVf https://cassyni.com/events/N5CoKJRDekZkmuGRp72fVf/abstract https://cassyni-user-files-prod.s3.amazonaws.com/KNYBn3qouvFJqDcrAoyHwc https://cassyni.com/events/N5CoKJRDekZkmuGRp72fVf?videoPreview=1 Measuring Core Stellar Magnetic Field using Wave Conversionnohttps://cassyni.com/events/N5CoKJRDekZkmuGRp72fVf?videoPreview=12021-01-28T12:00:00+00:004060.68Leeds Institute for Fluid DynamicsBy studying oscillation modes at the surface of stars, astrophysicists are able to infer characteristics of their deep interior structure. This was first applied to observations of the Sun, but recently space-based telescopes have measured oscillations in many other stars, leading to many new mysteries in stellar structure and evolution. Recent work has suggested that low dipole oscillation amplitudes in evolved red giant branch stars may indicate strong core magnetic fields. Here we present both numerical simulations and analytic calculations of the interactions of waves with a strong magnetic field. We can solve the problem very accurately by using the WKB approximation to reduce the 2D PDE into a series of ODEs for different heights. We find that magnetic fields convert the buoyancy-driven waves observable at the surface of the star to magnetic waves, which are not present at the surface, in agreement with observations.https://cassyni-user-files-prod.s3.amazonaws.com/KNYBn3qouvFJqDcrAoyHwc https://cassyni.com/slides/outline/PZepWgdkDcu5jwLvbzy8z9 https://cassyni.com/events/PZepWgdkDcu5jwLvbzy8z9/abstract https://cassyni-user-files-prod.s3.amazonaws.com/EayCKgA6DJ6gipFwr2BFNe https://cassyni.com/events/PZepWgdkDcu5jwLvbzy8z9?videoPreview=1 A systems-level analysis of the mutually antagonistic roles of RKIP and BACH1 in dynamics of cancer cell plasticitynohttps://cassyni.com/events/PZepWgdkDcu5jwLvbzy8z9?videoPreview=12024-05-02T15:00:00+00:002504.08Royal Society PublishingEpithelial–mesenchymal transition (EMT) is an important axis of phenotypic plasticity—a hallmark of cancer metastasis. Raf kinase-B inhibitor protein (RKIP) and BTB and CNC homology 1 (BACH1) are reported to influence EMT. In breast cancer, they act antagonistically, but the exact nature of their roles in mediating EMT and associated other axes of plasticity remains unclear. Here, analysing transcriptomic data, we reveal their antagonistic trends in a pan-cancer manner in terms of association with EMT, metabolic reprogramming and immune evasion via PD-L1. Next, we developed and simulated a mechanism-based gene regulatory network that captures how RKIP and BACH1 engage in feedback loops with drivers of EMT and stemness. We found that RKIP and BACH1 belong to two antagonistic ‘teams’ of players—while BACH1 belonged to the one driving pro-EMT, stem-like and therapy-resistant cell states, RKIP belonged to the one enabling pro-epithelial, less stem-like and therapy-sensitive phenotypes. Finally, we observed that low RKIP levels and upregulated BACH1 levels associated with worse clinical outcomes in many cancer types. Together, our systems-level analysis indicates that the emergent dynamics of underlying regulatory network enable the antagonistic patterns of RKIP and BACH1 with various axes of cancer cell plasticity, and with patient survival data.https://cassyni-user-files-prod.s3.amazonaws.com/EayCKgA6DJ6gipFwr2BFNe https://cassyni.com/events/6GxftkzNrbWy54af3fEmiV/seminar/qa https://cassyni.com/slides/outline/6GxftkzNrbWy54af3fEmiV https://cassyni.com/events/6GxftkzNrbWy54af3fEmiV/abstract https://cassyni-user-files-prod.s3.amazonaws.com/9HzDHFKjQLG28xEje5xykA https://cassyni.com/events/6GxftkzNrbWy54af3fEmiV?videoPreview=1 Feynman's Variational Principle and the Shape of RNA Moleculesnohttps://cassyni.com/events/6GxftkzNrbWy54af3fEmiV?videoPreview=12024-05-16T14:00:00+00:003940.64Journal of Biological PhysicsThe shape of large, single-stranded (ss) RNA molecules is important for an understanding of the assembly of viruses with ss RNA genomes as well for the functioning of ribo-enzymes and ribosomes. The shape of an RNA molecule is in principle determined by the topology of the secondary and tertiary structure. The talk will discuss how the three-dimensional shape of ss RNA macromolecules in solution can be obtained from a thermodynamic variational principle, used extensively by Feynman for problems in statistical mechanics and condensed matter physics, requiring only a modest computational effort.https://cassyni-user-files-prod.s3.amazonaws.com/9HzDHFKjQLG28xEje5xykA https://cassyni.com/slides/outline/3oiefLkkfJkS2uLsasSQiH https://cassyni.com/events/3oiefLkkfJkS2uLsasSQiH/abstract https://cassyni-user-files-prod.s3.amazonaws.com/4XMKx452rLJETZCJLYY822 https://cassyni.com/events/3oiefLkkfJkS2uLsasSQiH?videoPreview=1 Deep Learning of Hierarchical Multiscale Differential Equation Time Steppersnohttps://cassyni.com/events/3oiefLkkfJkS2uLsasSQiH?videoPreview=12021-02-05T14:00:00+00:001911.32Brunton LabThis video by Yuying Liu introduces a new deep learning architecture to accurately and efficiently integrate multiscale differential equations forward in time. This approach is benchmarked on several illustrative dynamical systems.https://cassyni-user-files-prod.s3.amazonaws.com/4XMKx452rLJETZCJLYY822 https://cassyni.com/events/G9vkpRvsdkbHvaagZE18rR/seminar/qa https://cassyni.com/slides/outline/G9vkpRvsdkbHvaagZE18rR https://cassyni.com/events/G9vkpRvsdkbHvaagZE18rR/abstract https://cassyni-user-files-prod.s3.amazonaws.com/4EBK3fZfv5qdbKA1NPE2ii https://cassyni.com/events/G9vkpRvsdkbHvaagZE18rR?videoPreview=1 Publishing for Sustainable Development: Impact Beyond Academianohttps://cassyni.com/events/G9vkpRvsdkbHvaagZE18rR?videoPreview=12024-06-20T14:30:00+00:002462.96Topics at the heart of our communityThe Springer Nature SDG Programme was established to help turn research into real-world policies and solutions which aid the Sustainable Development Goals. Join Nicola Jones - Director of the Springer Nature SDG Programme - as she reveals how SDG-related articles can create impact beyond academic citations, presenting data from Springer Nature’s wider journal programme. This event will feature the example of BMC Public Health, which undertook a pilot project to publish auto-generated societal impact summaries to accompany original research articles. Lorena Verduci, Associate Editor for the journal, will also share insights from this initiative.https://cassyni-user-files-prod.s3.amazonaws.com/4EBK3fZfv5qdbKA1NPE2ii https://cassyni.com/events/J8Yo7o2rnwjnAmZKCkoWub/seminar/qa https://cassyni.com/slides/outline/J8Yo7o2rnwjnAmZKCkoWub https://cassyni.com/events/J8Yo7o2rnwjnAmZKCkoWub/abstract https://cassyni-user-files-prod.s3.amazonaws.com/7ykhmvaFQAsJxyhAEP4pSa https://cassyni.com/events/J8Yo7o2rnwjnAmZKCkoWub?videoPreview=1 13th international Biometals webinarsnohttps://cassyni.com/events/J8Yo7o2rnwjnAmZKCkoWub?videoPreview=12025-03-04T14:00:00+00:004953.76BioMetalsCyanobacteria are ubiquitous photosynthetic prokaryotes with an enormous ecological importance. Their success largely depends on their interaction with the extracellular milieu and the expression of a battery of regulators that control cellular homeostasis. FUR (ferric uptake regulator) proteins are responsible for the control of a plethora of genes involved in metal homeostasis, nitrogen fixation and the response to oxidative stress, among other processes. Our aim was to study the consequences of deregulation of FUR proteins in the composition of the exoproteome of the filamentous, nitrogen-fixing Anabaena sp. PCC7120 to gain new insights into the roles of those proteins and the adaptive strategies of the cyanobacterium. Specifically, we analysed the differences between the exoproteomes of a zur (furB) mutant and a perR (furC)-overexpressing variant versus the WT Anabaena. Our studies with the zur deletion mutant led to the discovery of a novel protein, which we named ZepA (zinc-handling extracellular protein A). ZepA is a Zur target and plays a role in Zn uptake. Phylogenetic analysis indicates that ZepA is an ancient zinc acquisition system that has been conserved for billions of years in a few species across diverse bacterial lineages. Furthermore, Zur may have been one of the first regulators of the FUR, consistent with the scarcity of zinc in the early ecosystems. Comparative analysis of the exoproteome of the perR (furC)-overexpressing variant and the WT strain revealed that PerR contributes to proper nanopore formation and intercellular molecular transfer in the filament. Additionally, metabolomic and cell integrity analyses demonstrated that PerR plays a role in regulating peptidoglycan remodeling in Anabaena. Copper is an essential biometal for eukaryotes, with Saccharomyces cerevisiae housing about 17 Cu-proteins. My lab is interested in copper homeostasis, especially the role of the labile copper pool which we have probed using size-exclusion liquid chromatography with inline ICP-MS detection. In the study to be discussed, cytosol was isolated from cells grown on minimal media either supplemented with a Cu chelator (BCS) or with 0 – 250 uM CuSO4. Cu-containing species in the cytosol were characterized, including Cu-bound proteins and a diverse array of low-molecular-mass Cu complexes coordinated to non-proteinaceous ligands. Metallothionein CUP1 dominated in cytosol from Cu-sufficient and Cu-replete cells. Peak intensities were quantified and organized into groups. We had expected that cells would restrict the import of Cu when the media contained excess Cu, but this was not the case; cells imported Cu unabated at high nutrient Cu levels, but simultaneously increased expression of CUP1 which then sequestered most of the excess imported Cu. We have recently developed a mathematical (ordinary differential equations-based) model to better characterize this unusual homeostasis mechanism. The dynamical (time-dependent) model is stable to perturbations and able to replicate our experimental results. The model can explain the unusual mechanism of homeostasis and is highly testable. https://cassyni-user-files-prod.s3.amazonaws.com/7ykhmvaFQAsJxyhAEP4pSa https://cassyni.com/events/XU47NFW2eJgk3yruMywqaM/seminar/qa https://cassyni.com/slides/outline/XU47NFW2eJgk3yruMywqaM https://cassyni.com/events/XU47NFW2eJgk3yruMywqaM/abstract https://cassyni-user-files-prod.s3.amazonaws.com/PPa3MF4Jcac9xA2m6f8gvA https://cassyni.com/events/XU47NFW2eJgk3yruMywqaM?videoPreview=1 Using Community-based Participatory Action Research to Improve Clinical Care in Family Medicinenohttps://cassyni.com/events/XU47NFW2eJgk3yruMywqaM?videoPreview=12024-10-17T20:00:00+00:003164.16Family MedicineObjectives: At the conclusion of this session, attendees will be able to: - Describe how community-based participatory action research (CBPAR) processes have clinical applicability - Discuss the benefits and challenges of creating community research partnerships to improve clinical care - Identify steps in implementing and disseminating research results into clinical settingshttps://cassyni-user-files-prod.s3.amazonaws.com/PPa3MF4Jcac9xA2m6f8gvA https://cassyni.com/events/Bi7wWud35zY6LwrrLrR7JV/abstract https://cassyni-user-files-prod.s3.amazonaws.com/HZ1NuX4y62kTnonrxS4eht https://cassyni.com/slides/outline/DBXvUzmmkWbab96QQWjdAd https://cassyni.com/events/DBXvUzmmkWbab96QQWjdAd/abstract https://cassyni-user-files-prod.s3.amazonaws.com/8rJibnYpeBKVPXPbJDmqzv https://cassyni.com/events/DBXvUzmmkWbab96QQWjdAd?videoPreview=1 A theory of reproducing Hardy and Bergman spaces in octonionic settingsnohttps://cassyni.com/events/DBXvUzmmkWbab96QQWjdAd?videoPreview=12023-03-23T15:00:00+00:003541.72Journal of Mathematical SciencesWe intend present the theoretical fundament of octonionic Bergman and Hardy spaces of octonionic monogenic and slice monogenic functions. The non-associativity of the octonions implies that neither octonionic monogenic nor slice monogenic functions have the algebraic structure of an O-module. Consequently, there is no direct analogue of a Cauchy-Schwarz inequality neither a Fischer-Riesz representation theorem. In the first part of the presentation we explain how some of the fundamental problems in defining a reproducing kernel can be overcome in the non-associative setting by looking at the real part of an appropriately defined para-linear octonion-valued inner product. Para-linearity replaces the property of being octonionic linear properly, since the latter is too strong in the non-associative setting. Additionally, we shall see that the use of intrinsic weight factors is a further crucial ingredient in the non-asssociative case. Both for the monogenic and for the slice monogenic case we present explicit formulas for the reproducing kernels for some concrete domains. In this talk we present joint results with F. Colombo and I. Sabadini.https://cassyni-user-files-prod.s3.amazonaws.com/8rJibnYpeBKVPXPbJDmqzv https://cassyni.com/slides/outline/FemwiR1PwoN4x5ZxxCeFtZ https://cassyni.com/events/FemwiR1PwoN4x5ZxxCeFtZ/abstract https://cassyni-user-files-prod.s3.amazonaws.com/UUxsNz3JZChhrYfCX6X9Je https://cassyni.com/events/FemwiR1PwoN4x5ZxxCeFtZ?videoPreview=1 Chiral Lewis Bases for Asymmetric Organocatalysisnohttps://cassyni.com/events/FemwiR1PwoN4x5ZxxCeFtZ?videoPreview=12024-02-15T12:00:00+00:002287.04Tetrahedron Chem and Tetrahedron Green ChemChiral Lewis bases (LBs) are versatile nucleophilic organocatalysts that allow for numerous highly enantioselective transformations. Over the last years our group had a strong interest in the utilization of chiral LBs (i.e. isothioureas, phosphines, amines) for the activation and control of simple carboxylic acid derivatives (via in situ C1 ammonium enolate formation) and allenoates (via in situ betaine formation) for numerous applications. In this presentation I will give an overview of our most recent results, presenting past and ongoing investigations focusing on the development and mechanistic understanding of new cyclization reactions as well as new a-functionalization chemistry. https://cassyni-user-files-prod.s3.amazonaws.com/UUxsNz3JZChhrYfCX6X9Je https://cassyni.com/slides/outline/P4XdXJE9w2bdb8nqCeSRwB https://cassyni.com/events/P4XdXJE9w2bdb8nqCeSRwB/abstract https://cassyni-user-files-prod.s3.amazonaws.com/NM2tYNRe69MmSxDeiNgyin https://cassyni.com/events/P4XdXJE9w2bdb8nqCeSRwB?videoPreview=1 Perspectives on AI/ML in Chemistry from Academia and Industrynohttps://cassyni.com/events/P4XdXJE9w2bdb8nqCeSRwB?videoPreview=12023-03-08T09:00:00+00:006688.6Thieme GroupThe growing importance of machine learning (ML) and artificial intelligence (AI) extends to chemical research. The need for computational access to and reuse of research data for the prediction of chemical products and retrosynthetic routes is increasing rapidly. In this Thieme WebCheminar, chaired by Dr. Guido Koch (Amphilix, Switzerland), our speakers will talk about challenges for researchers in accessing data, tangible benefits for practicing chemists in predicting synthetic routes and the mind shift required for the application of new digital technologies for discovery of new active ingredients in industry.https://cassyni-user-files-prod.s3.amazonaws.com/NM2tYNRe69MmSxDeiNgyin https://cassyni.com/events/YSr7QHX8Gj7uStFy7muzoo/abstract https://cassyni-user-files-prod.s3.amazonaws.com/3a8L343TM59eywJdAkVPQa https://cassyni.com/slides/outline/R383i2pFgrpPgr54ZcJNMj https://cassyni.com/events/R383i2pFgrpPgr54ZcJNMj/abstract https://cassyni-user-files-prod.s3.amazonaws.com/8vUSKgqdqftGsB3EqMtm5G https://cassyni.com/events/R383i2pFgrpPgr54ZcJNMj?videoPreview=1 Tacit Knowledge, Audit Quality, and Talent Identificationnohttps://cassyni.com/events/R383i2pFgrpPgr54ZcJNMj?videoPreview=12024-03-21T22:00:00+00:004333.44SACLThe auditing literature has recently transitioned from the focus on client- or audit firm-level characteristics and their relation with audit quality to the inclusion of audit partner and team effects in audit quality. We extend this literature by studying whether tacit knowledge is a relevant factor in achieving high audit quality. Using survey measures and unique proprietary data of a Big 4 firm, we find evidence that the engagement partners’ level of tacit knowledge explains variation in audit quality as defined by the firm’s internal assessment of audit quality. Given its value-creating character, we subsequently examine whether tacit knowledge is a criterion that is incorporated in the talent identification process. We find that tacit knowledge is largely ignored or even negatively correlated with the firm’s assessment of potential, which likely provides an explanation for the loss of talent in professional audit firms. Paper available via this [Tresorit link](https://web.tresorit.com/l/4A8ET#z1xFuLOrKx5sc7ovbISJEw). https://cassyni-user-files-prod.s3.amazonaws.com/8vUSKgqdqftGsB3EqMtm5G https://cassyni.com/events/TWN4wT3st9at3nYd7JD15f/abstract https://cassyni-user-files-prod.s3.amazonaws.com/SuCYTyvPTnNDnFTWWcHEyC https://cassyni.com/slides/outline/QZ2twwUTJcnWCZnaPt3FFT https://cassyni.com/events/QZ2twwUTJcnWCZnaPt3FFT/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Kj3VK3HmAKp5pJ2tScqQ4e https://cassyni.com/events/QZ2twwUTJcnWCZnaPt3FFT?videoPreview=1 Womens’ Bladder Health and the Microbiomenohttps://cassyni.com/events/QZ2twwUTJcnWCZnaPt3FFT?videoPreview=12024-06-11T12:00:00+00:001142.0Microbiome Virtual International Forum In the decade following the discovery of the urobiome, more than 14000 urobiome genomes have been contributed to Greengenes2, facilitating rapid expansion of our understanding of the urobiome in various bladder health states. This presentation will highlight ongoing research designed to correlate bladder health and the urobiome.https://cassyni-user-files-prod.s3.amazonaws.com/Kj3VK3HmAKp5pJ2tScqQ4e https://cassyni.com/events/WUjHAFh6N2esEkLVySY58q/seminar/qa https://cassyni.com/slides/outline/WUjHAFh6N2esEkLVySY58q https://cassyni.com/events/WUjHAFh6N2esEkLVySY58q/abstract https://cassyni-user-files-prod.s3.amazonaws.com/8Xf7Agrxi9Vopwow6Q34bY https://cassyni.com/events/WUjHAFh6N2esEkLVySY58q?videoPreview=1 The Experimental Generation of Streamwise Gusts and their Impact on a Finite-Span Wingnohttps://cassyni.com/events/WUjHAFh6N2esEkLVySY58q?videoPreview=12024-06-14T14:00:00+00:002979.88Department of AeronauticsUnder normal operation, aircraft and wind turbines frequently encounter gusts, or discrete unsteady variations in the direction and magnitude of the freestream velocity. Streamwise gusts, which impose changes in the magnitude of the freestream, can dramatically alter the aerodynamic response of these systems when the gust length-scales, time-scales or magnitudes are commensurate with the steady operating conditions of these systems. To study these interactions a unique unsteady low-speed wind tunnel facility was constructed at the University of Colorado Boulder which can generate both convective and global streamwise velocity disturbances. The design, modeling, and performance of this facility will be presented along with the aerodynamic response of a canonical finite-span rectangular wing section to a time-varying freestream. More specifically, the seminar will focus on how the convective nature of the streamwise velocity disturbances can couple with wing sweep to impose dramatic variations in the pitching moment response of a simple wing section. In addition to this primary topic, a summary of other basic research efforts ongoing in the Experimental Aerodynamics Laboratory at the University of Colorado Boulder will also be given.https://cassyni-user-files-prod.s3.amazonaws.com/8Xf7Agrxi9Vopwow6Q34bY https://cassyni.com/slides/outline/RYFEhRDqyT7qqed9xxq5Qh https://cassyni.com/events/RYFEhRDqyT7qqed9xxq5Qh/abstract https://cassyni-user-files-prod.s3.amazonaws.com/SK6aom15wi93C2mh2SZYzi https://cassyni.com/events/RYFEhRDqyT7qqed9xxq5Qh?videoPreview=1 AI/ML+Physics Part 3: Designing an Architecturenohttps://cassyni.com/events/RYFEhRDqyT7qqed9xxq5Qh?videoPreview=12024-03-08T12:00:00+00:002189.88Brunton LabThis video discusses the third stage of the machine learning process: (3) choosing an architecture with which to represent the model. This is one of the most exciting stages, including all of the new architectures, such as UNets, ResNets, SINDy, PINNs, Operator networks, and many more. There are opportunities to incorporate physics into this stage of the process, such as incorporating known symmetries through custom equivariant layers. SLB acknowledges support from the National Science Foundation AI Institute in Dynamic Systems and from The Boeing Company.https://cassyni-user-files-prod.s3.amazonaws.com/SK6aom15wi93C2mh2SZYzi https://cassyni.com/slides/outline/8kCh8BE13tHTS14DbM9QSR https://cassyni.com/events/8kCh8BE13tHTS14DbM9QSR/abstract https://cassyni-user-files-prod.s3.amazonaws.com/BmEEWfZMbd2WVtiJBmscU6 https://cassyni.com/events/8kCh8BE13tHTS14DbM9QSR?videoPreview=1 Urban aerodynamics and turbulent dispersionnohttps://cassyni.com/events/8kCh8BE13tHTS14DbM9QSR?videoPreview=12024-05-02T13:00:00+00:003486.64The Edinburgh Fluid Dynamics Group (EFDG)Exposure to poor air quality in urban areas is one of the largest environmental health risks in the UK. Accurate pollution dispersion models are important for air quality forecasting and to inform urban planning and policy. There is currently a gap in understanding in how air pollution spreads at local scales (those relevant to pedestrians) and how it can be affected by heterogeneous urban terrain. This talk describes high-fidelity experiments of urban aerodynamics using scale models in a water flume facility and a passive dye as a surrogate for air pollution. Simultaneous Particle Image Velocimetry (PIV) and Planar Laser-Induced Fluorescence (PLIF) capture full two-dimensional quantitative images of the velocity and concentration at the fine scales near the pollution sources and at the city scale. The results highlight the role of tall buildings and local geometry on the relative importance of advection and turbulent diffusion processes. In this context, the strengths and limitations of current turbulent dispersion models are discussed for simplified, urban, and indoor applications. https://cassyni-user-files-prod.s3.amazonaws.com/BmEEWfZMbd2WVtiJBmscU6 https://cassyni.com/slides/outline/LUdRvX8U1ywfxsK3BXmzM https://cassyni.com/events/LUdRvX8U1ywfxsK3BXmzM/abstract https://cassyni-user-files-prod.s3.amazonaws.com/KzEfRT1qyTG2fKVRD9Fijg https://cassyni.com/events/LUdRvX8U1ywfxsK3BXmzM?videoPreview=1 Turbulent flow nohttps://cassyni.com/events/LUdRvX8U1ywfxsK3BXmzM?videoPreview=12024-06-12T10:00:00+00:006054.92Nektar++ Development TeamThis session is focused on turbulent flows and comprises the following talks: 1. Unveiling Hidden Order in Turbulence: Quiescent Interludes and Invariant States in Square-Duct Flow 2. Compressible synthetic turbulence generator in Nektar++. 3. Turbomachinery Applications of Nektar++https://cassyni-user-files-prod.s3.amazonaws.com/KzEfRT1qyTG2fKVRD9Fijg https://cassyni.com/slides/outline/Aio7Jup6oiWDXiLSxK1Lry https://cassyni.com/events/Aio7Jup6oiWDXiLSxK1Lry/abstract https://cassyni-user-files-prod.s3.amazonaws.com/SqC2v4u947DJunp9b4hQ6J https://cassyni.com/events/Aio7Jup6oiWDXiLSxK1Lry?videoPreview=1 What's in a mean (what, how and why)? Towards nonlinear models of wall turbulencenohttps://cassyni.com/events/Aio7Jup6oiWDXiLSxK1Lry?videoPreview=12021-02-19T14:00:00+00:003189.92AI Institute in Dynamic SystemsIn this talk I will discuss the fusion of analytical and data-based approaches to understanding the nonlinear interactions sustaining turbulence near a wall. Exploiting information embedded in the turbulent mean field (and how it gets there) using resolvent analysis, emphasis will be placed on discovering strict rules governing the important scale-to-scale interactions. By consideration of a range of flow configurations, a dramatic reduction in complexity of these problems will be demonstrated, associated with sparsity, self-similarity and low-rank behavior in the resolvent (attributable to the information encoded in the turbulent mean field). In this talk, we will synthesize data and classical analysis techniques to distill clues guiding reconstruction of the full nonlinear flow field from the most amplified spatio-temporal modes, and the associated characteristics of the mean field.https://cassyni-user-files-prod.s3.amazonaws.com/SqC2v4u947DJunp9b4hQ6J https://cassyni.com/slides/outline/BDSiMbTdFB4GXUsLYkJ98H https://cassyni.com/events/BDSiMbTdFB4GXUsLYkJ98H/abstract https://cassyni-user-files-prod.s3.amazonaws.com/7LSButATjQ5XMubNUJMw8a https://cassyni.com/events/BDSiMbTdFB4GXUsLYkJ98H?videoPreview=1 Partial thermal acclimation of photosynthetic heat tolerance in tropical treesnohttps://cassyni.com/events/BDSiMbTdFB4GXUsLYkJ98H?videoPreview=12024-06-06T20:05:00+00:00983.16New Phytologist Foundation Climate warming increases the risk of harmful leaf temperatures in terrestrial plants, causing heat stress and loss of productivity. Heat sensitivity may be particularly high in tropical tree species adapted to a thermally stable climate. Heat tolerance thresholds of photosynthetic reactions were investigated in sun-exposed leaves of 12 tropical montane tree species with different growth and water-use strategies. Chlorophyll a fluorescence, leaf gas exchange, leaf morphology and lipid composition were measured at three common gardens along an elevation and temperature gradient. Photosynthetic heat tolerance partially acclimated to increased growth temperature; on average 0.31°C increase in heat tolerance per 1°C increase in growth temperature. Consequently, thermal safety margins were narrower for species at the warmer, lower-elevation sites. Moreover, although tree species with traits that predispose them to higher leaf temperatures (low stomatal conductance and big leaves) had higher photosynthetic heat tolerance, their thermal safety margins were smaller. Heat tolerance and its acclimation were linked to the adjustment of fatty acid composition and membrane fluidity. Our results suggest that tropical trees have some capacity to thermally acclimate to increasing temperatures, but not strong enough to prevent increased heat stress in a warming climate.https://cassyni-user-files-prod.s3.amazonaws.com/7LSButATjQ5XMubNUJMw8a https://cassyni.com/slides/outline/Mb62SaZXs9cRCTrsrRBUSR https://cassyni.com/events/Mb62SaZXs9cRCTrsrRBUSR/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Sit9yiJoxcojQSXJnTsSFY https://cassyni.com/events/Mb62SaZXs9cRCTrsrRBUSR?videoPreview=1 Exploring the Genomic Landscape of Local Adaptation in Serpentine Mimulus guttatusnohttps://cassyni.com/events/Mb62SaZXs9cRCTrsrRBUSR?videoPreview=12024-06-08T16:15:00+00:00930.08New Phytologist Foundation Local adaptation arises when spatially divergent selection outpaces migration rates between habitats. Population-genomic scans often reveal candidate genes for local adaptation but struggle to quantify selection strength. Serpentine outcrops are ideal for studying local adaptation because their patchy distribution results in landscapes with abrupt changes from “normal soils” to serpentine. Serpentine soils are unconducive to most plant life due to low Ca:Mg ratios, limited macronutrients, and elevated heavy metals. Reciprocal transplant experiments in model system Mimulus guttatus reveal extreme local adaptation to serpentine. Population genomic scans of pairs of adjacent serpentine and non-serpentine populations have identified dozens of candidate genes under divergent selection. What are the relative fitness contributions of these genes? I marry a classic mapping experiment with an Evolve & Resequence approach to estimate fitness effects of each loci. I crossed two inbred lines, from adjacent serpentine and non-serpentine habitats, to form F2 progeny. I planted thousands of progeny on serpentine and control soils in the greenhouse, using captive bumblebees to ensure outcrossing. Survivor seeds, planted on parental soils, enable multi-generational adaptation. Pool-sequencing of each population detects loci responding to divergent selection, revealing key loci driving local adaptation to serpentine soil.https://cassyni-user-files-prod.s3.amazonaws.com/Sit9yiJoxcojQSXJnTsSFY https://cassyni.com/slides/outline/LbnpMDGUzEWGXi2skSi9dX https://cassyni.com/events/LbnpMDGUzEWGXi2skSi9dX/abstract https://cassyni-user-files-prod.s3.amazonaws.com/GnDthanwJnTR7wrVGwnJE2 https://cassyni.com/events/LbnpMDGUzEWGXi2skSi9dX?videoPreview=1 Mapping the global ocean genomenohttps://cassyni.com/events/LbnpMDGUzEWGXi2skSi9dX?videoPreview=12024-02-21T17:00:00+00:005422.84Frontiers in ScienceThe global ocean genome (the pool of genes in marine organisms and the functional information they encode) is a major, untapped resource for science and society with a growing range of biotechnology applications in sectors such as biomedicine, energy, and food. Shotgun sequencing and metagenomics can now be used to catalog the diversity of ocean microbial life and to explore its functional potential, but has been limited by sample coverage, access to suitable sequencing platforms, and computational capacity. Here we provide a novel synthesis of the global ocean genome based on analysis of 2,102 sampled ocean metagenomes, with gene assembly and annotation via the KAUST Metagenome Analysis Platform (KMAP) Global Ocean Gene Catalog 1.0 containing 308.6 million gene clusters. Taxonomically, we report the distribution of marine genes across the tree of life and different ocean basins and depth zone biomes. Functionally, we map its relationship to protein families and biogeochemical processes, including the major microbial metabolic pathways that process three elements that play fundamental roles in biogeochemical cycles and are relevant to climate change. These data extend our understanding of the complex, dynamic nature of the ocean microbiome and its metabolic capabilities. Further research is of critical global importance both to unlock the potential of the ocean genome and to understand and predict the effects of human-induced changes, including pollution and climate change. Further hypothesis-driven research should target under-sampled deep sea and benthic microbial communities using enhanced metagenomic methods, to better understand marine ecosystem functioning. Investment in the necessary computational capacity is essential, as are suitable intellectual property frameworks. https://cassyni-user-files-prod.s3.amazonaws.com/GnDthanwJnTR7wrVGwnJE2 https://cassyni.com/slides/outline/7GHW6koK8sYqtJ74SCeYA1 https://cassyni.com/events/7GHW6koK8sYqtJ74SCeYA1/abstract https://cassyni-user-files-prod.s3.amazonaws.com/2ywPnTKpdriP87Z9GcarTY https://cassyni.com/events/7GHW6koK8sYqtJ74SCeYA1?videoPreview=1 PCAN Podcast Episode 5: Stacy Loeb and Genetic Tumour Boardnohttps://cassyni.com/events/7GHW6koK8sYqtJ74SCeYA1?videoPreview=12024-03-30T14:00:00+00:001428.8Research Seminars by Springer NatureNo abstracthttps://cassyni-user-files-prod.s3.amazonaws.com/2ywPnTKpdriP87Z9GcarTY https://cassyni.com/slides/outline/q9rbEgYJqTmVRrpqHekAZ https://cassyni.com/events/q9rbEgYJqTmVRrpqHekAZ/abstract https://cassyni-user-files-prod.s3.amazonaws.com/BuTJ7m3v1hNC9xeKXbeGDc https://cassyni.com/events/q9rbEgYJqTmVRrpqHekAZ?videoPreview=1 Radiation Belts of the Outer Planetsnohttps://cassyni.com/events/q9rbEgYJqTmVRrpqHekAZ?videoPreview=12024-07-11T14:00:00+00:001424.12MOP2024Planets with an intrinsic magnetic field trap and accelerate charged particles, and form radiation belts. These belts exist in a permanent interplay of different physical processes: Particles are initially provided, e.g., through erupted moon material, and accelerated to high energies, e.g., through transport into the stronger parts of the planet’s magnetic field. Particle production is countered through the removal of particles, e.g., when they hit the planet. Particle acceleration in turn is balanced through slowing the particles down again, e.g., when emitting synchrotron radiation. The balance of the involved processes determines the structure and dynamics of the various radiation belts. This presentation will discuss the processes that are currently considered as most important at Jupiter and Saturn, and illustrate them through examples. We will briefly review the current state of the relative importance of these processes, although that topic is far from being closed, even at well-explored planets. Comparison with Earth will provide context and demonstrate how some physical processes are potentially better studied at one planet than another. We will discuss some of the limited data we have for the radiation belts of the moon Ganymede, as well as the Ice Giants. While these data are far from conclusive, they reveal open questions or even mysteries that are left for future missions, such as JUICE or an Ice Giant flagship. We will discuss how the study of radiation belts also has an impact on several other fields of planetary science and, e.g., how it informs on ring structure.https://cassyni-user-files-prod.s3.amazonaws.com/BuTJ7m3v1hNC9xeKXbeGDc https://cassyni.com/slides/outline/EBMxkKrfHHJdP76doeDUJh https://cassyni.com/events/EBMxkKrfHHJdP76doeDUJh/abstract https://cassyni-user-files-prod.s3.amazonaws.com/NDuPwMTqTUTXHK7uz7fzfG https://cassyni.com/events/EBMxkKrfHHJdP76doeDUJh?videoPreview=1 The angiogenic growth of citiesnohttps://cassyni.com/events/EBMxkKrfHHJdP76doeDUJh?videoPreview=12024-07-24T13:00:00+00:003318.6Royal Society PublishingDescribing the space–time evolution of urban population is a fundamental challenge in the science of cities, yet a complete theoretical treatment of the underlying dynamics is still missing. Here, we first reconstruct the evolution of London (UK) over 180 years and show that urban growth consists of an initial phase of diffusion-limited growth, followed by the development of the railway transport network and a consequential shift from central to suburban living. Such dynamics—which are analogous to angiogenesis in biological systems—can be described by a minimalist reaction–diffusion model coupled with economic constraints and an adaptive transport network. We then test the generality of our approach by reproducing the evolution of Sydney, Australia, from 1851 to 2011. We show that the rail system coevolves with urban population, displaying hierarchical characteristics that remain constant over time unless large-scale interventions are put in place to alter the modes of transport. These results demonstrate that transport schemes are first-order controls of long-term urbanization patterns and efforts aimed at creating more sustainable and healthier cities require careful consideration of population–transport feedbacks. Photo credit: [NASA](https://commons.wikimedia.org/wiki/File:Bucharest_night_from_the_International_Space_Station.jpg)https://cassyni-user-files-prod.s3.amazonaws.com/NDuPwMTqTUTXHK7uz7fzfG https://cassyni.com/slides/outline/Gebyyk6HUa57k3aCML872d https://cassyni.com/events/Gebyyk6HUa57k3aCML872d/abstract https://cassyni-user-files-prod.s3.amazonaws.com/FvfmqvGKathLvmhLEfvPqY https://cassyni.com/events/Gebyyk6HUa57k3aCML872d?videoPreview=1 Bicommutant theorems in vector lattices and Banach latticesnohttps://cassyni.com/events/Gebyyk6HUa57k3aCML872d?videoPreview=12021-06-03T14:00:00+00:002062.96Positivity Journal, SpringerNatureVon Neumann's bicommutant theorem states that the bicommutant of a unital involutive subalgebra of the bounded operators on a Hilbert space is precisely its closure in the strong operator topology. We present several analogues of this in the context of vector lattices and Banach lattices. This is joint work with Björn de Rijk and Marcel de Jeu.https://cassyni-user-files-prod.s3.amazonaws.com/FvfmqvGKathLvmhLEfvPqY https://cassyni.com/events/Q4MfndK3ToJgP6o4bmvH5F/seminar/qa https://cassyni.com/slides/outline/Q4MfndK3ToJgP6o4bmvH5F https://cassyni.com/events/Q4MfndK3ToJgP6o4bmvH5F/abstract https://cassyni-user-files-prod.s3.amazonaws.com/9GYATJ1U4DsattiVnxYeRL https://cassyni.com/events/Q4MfndK3ToJgP6o4bmvH5F?videoPreview=1 Impact of lifestyle on cardiovascular and renal outcomesnohttps://cassyni.com/events/Q4MfndK3ToJgP6o4bmvH5F?videoPreview=12024-10-08T10:45:00+00:001791.04North West London Kidney CareLifestyle factors contribute to nearly 80% of chronic disease risk yet we rarely spend much time or resource in providing patients with quality lifestyle advice or support. We can't afford to neglect this area any longer. This talk will provide evidence and practical steps which will hopefully make you rethink your own lifestyle as well as changing your consultation style.https://cassyni-user-files-prod.s3.amazonaws.com/9GYATJ1U4DsattiVnxYeRL https://cassyni.com/events/JdE2H7CGdmDbzEYpzrvV5o/abstract https://cassyni-user-files-prod.s3.amazonaws.com/2ra6USYNnfwzbbQFRgyuhG https://cassyni.com/slides/outline/K7sdKnqo5Dmez15ibJDHM7 https://cassyni.com/events/K7sdKnqo5Dmez15ibJDHM7/abstract https://cassyni-user-files-prod.s3.amazonaws.com/THP2w2poS38AU55zGYpcSa https://cassyni.com/events/K7sdKnqo5Dmez15ibJDHM7?videoPreview=1 AI in Clinical Advanced Analytics at Fresenius Medical Carenohttps://cassyni.com/events/K7sdKnqo5Dmez15ibJDHM7?videoPreview=12024-08-21T09:00:00+00:004820.04NoneExample projects include: - Access to Home Therapy - Acuity Scores for Dietitians and Social Workershttps://cassyni-user-files-prod.s3.amazonaws.com/THP2w2poS38AU55zGYpcSa https://cassyni.com/events/S2x5yMu9DdXSUp5HxjnDVo/abstract https://cassyni-user-files-prod.s3.amazonaws.com/33oFt7E5kub6Psmv4h5PKt https://cassyni.com/slides/outline/UWC7Cn8mQvHvqkYrWRgrDj https://cassyni.com/events/UWC7Cn8mQvHvqkYrWRgrDj/abstract https://cassyni-user-files-prod.s3.amazonaws.com/MDA38sKets2jiaUQ8PvdKt https://cassyni.com/events/UWC7Cn8mQvHvqkYrWRgrDj?videoPreview=1 Critical Assessment of Metagenome Interpretation - the second round of challengesnohttps://cassyni.com/events/UWC7Cn8mQvHvqkYrWRgrDj?videoPreview=12021-09-14T13:00:00+00:00663.12Microbiome Virtual International ForumEvaluating metagenomic software is key for optimizing metagenome interpretation and focus of the community-driven initiative for the Critical Assessment of Metagenome Interpretation (CAMI). In its second challenge, CAMI engaged the community to assess their methods on realistic and complex metagenomic datasets with long and short reads, created from ∼1,700 novel and known microbial genomes, as well as ∼600 novel plasmids and viruses. Altogether 5,002 results by 76 program versions were analyzed, representing a 22x increase in results. Substantial improvements were seen in metagenome assembly, some due to using long-read data. The presence of related strains still was challenging for assembly and genome binning, as was assembly quality for the latter. Taxon profilers demonstrated a marked maturation, with taxon profilers and binners excelling at higher bacterial taxonomic ranks, but underperforming for viruses and archaea. Assessment of clinical pathogen detection techniques revealed a need to improve reproducibility. Analysis of program runtimes and memory usage identified highly efficient programs, including some top performers with other metrics. The CAMI II results identify current challenges, but also guide researchers in selecting methods for specific analyses.https://cassyni-user-files-prod.s3.amazonaws.com/MDA38sKets2jiaUQ8PvdKt https://cassyni.com/slides/outline/5Hii2ej6nQGBLpd1gcrscH https://cassyni.com/events/5Hii2ej6nQGBLpd1gcrscH/abstract https://cassyni-user-files-prod.s3.amazonaws.com/HFyCmQ9TPCbxLg7W46UQyC https://cassyni.com/events/5Hii2ej6nQGBLpd1gcrscH?videoPreview=1 Healthy urogenital microbiome as a source of putative uropathogenic strains - Escherichia coli in the spotlightnohttps://cassyni.com/events/5Hii2ej6nQGBLpd1gcrscH?videoPreview=12021-11-09T15:00:00+00:0063.12Microbiome Virtual International Forum To date, the human gut is recognized as primary reservoir of extraintestinal pathogenic Escherichia coli (ExPEC) strains, followed by vagina. However, since the discovery of urinary microbiome, the origin of microbes associated with UTI is of high interest. We aimed to explore population diversity of E. coli strains identified in urogenital microbiome of asymptomatic and recurrent UTI (rUTI) women. Additionally, we investigated genomic relation between E. coli strains isolated from healthy and diseased host. We performed thorough characterization [41 virulence-associated genes (VAGs) and phylogenetic groups] of 70 E. coli recovered from voided urine and vaginal samples. We further performed whole genome sequencing and antimicrobial susceptibility testing of 11 representative B2 ExPEC clones. Following, we performed SNP-based phylogenetic analysis and comparative genomics with E. coli genomes available in public databases, focusing on ST131 lineage. We identified E. coli in 48% of asymptomatic women and in all rUTI women. We observed different E. coli prevalence in urine (29%) and in vaginal samples (37%). Most of women were colonized by only one strain, while in 4 women we found more than one E. coli strain in urine and/or vagina. The most frequently identified phylogenetic group was B2 (56%) followed mostly by F and D. Most B2 and all F strains were classified as ExPEC and possess an array of VAGs, independently of host health status. Hierarchical clustering based on VAGs presence/absence confirmed that it is not possible to distinguish strains isolated from healthy and rUTI host based on their VAG profiles. We identified well recognized widespread lineages among our isolates e.g., sequence types (ST) 127, ST131, ST140 (asymptomatic) and ST12, ST73, ST131 (rUTI). Our isolates were occasionally resistant to antibiotics used in the clinic, with ST131 strain (asymptomatic woman) showing the highest resistance rate (6 antibiotics from 4 classes). Phylogenomics of ST131 and other analyzed lineages revealed close relatedness of genomes from healthy and diseased host and no phylogenetic distinction according to host health status. Our findings demonstrate that healthy urogenital microbiome is a source of potentially pathogenic E. coli strains, including lineages causing UTI e.g., ST131. A high prevalence of ExPEC clones, occasionally resistant to antibiotics should be of clinical concern and likely raises questions regarding etiology of UTI-associated clones.https://cassyni-user-files-prod.s3.amazonaws.com/HFyCmQ9TPCbxLg7W46UQyC https://cassyni.com/slides/outline/7kxjG4xiyh2fhm6aEJmWLD https://cassyni.com/events/7kxjG4xiyh2fhm6aEJmWLD/abstract https://cassyni-user-files-prod.s3.amazonaws.com/E3ttY71yYXeNJ1267emveS https://cassyni.com/events/7kxjG4xiyh2fhm6aEJmWLD?videoPreview=1 Variation and transmission of the human gut microbiota across multiple familial generationsnohttps://cassyni.com/events/7kxjG4xiyh2fhm6aEJmWLD?videoPreview=12022-01-11T16:00:00+00:0057.32Microbiome Virtual International Forum Although the composition and functional potential of the human gut microbiota evolve over the lifespan, kinship has been identified as a key covariate of microbial community diversification. However, to date, sharing of microbiota features within families has mostly been assessed between parents and their direct offspring. Here we investigate the potential transmission and persistence of familial microbiome patterns and microbial genotypes in a family cohort (n = 102) spanning 3 to 5 generations over the same female bloodline. We observe microbiome community composition associated with kinship, with seven low abundant genera displaying familial distribution patterns. While kinship and current cohabitation emerge as closely entangled variables, our explorative analyses of microbial genotype distribution and transmission estimates point at the latter as a key covariate of strain dissemination. Highest potential transmission rates are estimated between sisters and mother–daughter pairs, decreasing with increasing daughter’s age and being higher among cohabiting pairs than those living apart. Although rare, we detect potential transmission events spanning three and four generations, primarily involving species of the genera Alistipes and Bacteroides. Overall, while our analyses confirm the existence of family-bound microbiome community profiles, transmission or co-acquisition of bacterial strains appears to be strongly linked to cohabitation. Link to the OA paper: https://www.nature.com/articles/s41564-021-01021-8https://cassyni-user-files-prod.s3.amazonaws.com/E3ttY71yYXeNJ1267emveS https://cassyni.com/events/4JRVwHS3uVA2g4o1aePYoP/abstract https://cassyni-user-files-prod.s3.amazonaws.com/SdvDqUwG1iKtdg4DjqmWJJ https://cassyni.com/events/4JRVwHS3uVA2g4o1aePYoP?videoPreview=1 Effect of cecal microbiota transplantation between different broiler breeds on the chick flora in the first week of lifenohttps://cassyni.com/events/4JRVwHS3uVA2g4o1aePYoP?videoPreview=12022-03-08T15:00:00+00:0058.04Microbiome Virtual International Forum Microbiota transplantation studies in chickens represent a fascinating opportunity to study the impact of early-life microbiota manipulation on important phenotypes such as pathogen resistance and nutrition. When chicks are raised by a maternal hen, they quickly develop a gastrointestinal microbiota that is similar to their mother. However, commercially-raised chicks have no direct contact with maternal hens or their faeces. They subsequently develop a less-diverse microbiota that is seeded from their environment. By delivering microbiota transplants from chickens with a desired phenotype to chicks raised without maternal contact we can define the trajectory of their microbiota development. This allows us to examine the impact of the transplanted microbiota on the development of desired phenotypes. However, studies have shown varying success when attempting to conduct microbiota transplants in chickens, potentially due to the variability of techniques used. We investigated whether it was possible to transplant the caecal microbiota between 40 week old adult chickens and freshly hatched chicks from a different chicken breed. Caecal contents were collected from the adult birds and within 30 minutes were administered orally to chicks. The microbiota of treated and control chicks was characterised via 16S rRNA gene sequencing at 1, 2, 3, 4, and 7 days post-hatch. At all timepoints, the microbiota of treated chicks was significantly different in composition and richer and more diverse than control birds. Transplantation clearly changed the trajectory of the treated birds so that they developed a microbiota which was far more similar to the donor birds than the control chicks. The most notable taxonomic difference between control and treated birds was the abundance of the phylum Bacteroidota. This phylum was present in high relative abundance in the donor samples (38%) and also in the treated samples (day 7: 41%). However, it was almost completely absent from the control birds (Day7: 0.02%). We therefore demonstrate that our technique is highly effective at transplanting the caecal microbiota between adult donors and chicks from a different chicken breed. This technique could be further used to study the role of the microbiota in chicken breeds with differing phenotypes. Link to OA paper: https://www.sciencedirect.com/science/article/pii/S0032579121006453https://cassyni-user-files-prod.s3.amazonaws.com/SdvDqUwG1iKtdg4DjqmWJJ https://cassyni.com/slides/outline/Eg3Bue2586nTCa69bkLSUu https://cassyni.com/events/Eg3Bue2586nTCa69bkLSUu/abstract https://cassyni-user-files-prod.s3.amazonaws.com/S2bAo3wZnX91hQLCSQqRQz https://cassyni.com/events/Eg3Bue2586nTCa69bkLSUu?videoPreview=1 The greenhouse phyllosphere microbiome and associations with introduced bumblebees and predatory mitesnohttps://cassyni.com/events/Eg3Bue2586nTCa69bkLSUu?videoPreview=12022-09-13T12:00:00+00:00772.04Microbiome Virtual International Forum Greenhouses are highly productive environments in which conditions are regulated to optimize plant growth. The enclosed character of greenhouses usually results in reduced microbial diversity, while it is known that a diverse microbiome is important for plant health. Therefore, we explored the phyllosphere microbiome of tomatoes and strawberries grown in greenhouses. We observed that the microbiome of both crops was low in diversity and abundance, and varied considerably over time and space. Interestingly, the core taxa of tomatoes were Snodgrasella and Gilliamella, genera typically associated with bumblebees. The same amplicon sequence variants (ASVs) were found on reared bumblebees, indicating that bumblebees, present in the sampled greenhouses to pollinate flowers, had introduced and dispersed these bacteria in greenhouses. Overall, we found that 80% of plants contained bumblebee-associated taxa, and on these plants, bumblebee-associated reads accounted up to a quarter of reads on tomatoes and a tenth of reads on strawberries. Furthermore, predatory mites had been introduced for the control of spider mites. Their microbiome was composed of a diverse set of bacteria, which varied between batches ordered at different times. Still, identical ASVs were found on mites and crops and these belonged to the genera Sphingomonas, Staphylococcus, Methylobacterium and Pseudomonas. These new insights should now be further explored and utilized to diversify these ecosystems that are characterized by low diversity and abundancy of microbes.https://cassyni-user-files-prod.s3.amazonaws.com/S2bAo3wZnX91hQLCSQqRQz https://cassyni.com/slides/outline/9jZ9SoYpjXFRoUNobGdSkm https://cassyni.com/events/9jZ9SoYpjXFRoUNobGdSkm/abstract https://cassyni-user-files-prod.s3.amazonaws.com/PvqMM9SavKnEBSjBx4gMMY https://cassyni.com/events/9jZ9SoYpjXFRoUNobGdSkm?videoPreview=1 Human gut microbiome-dependent energy-extractionnohttps://cassyni.com/events/9jZ9SoYpjXFRoUNobGdSkm?videoPreview=12023-01-16T12:00:00+00:00588.04Microbiome Virtual International Forum More than 15 years ago, it was hypothesised that the gut microbiota could causally affect weight gain due to the gut microbiome’s capacity to extract energy from the diet. Yet, evidence linking microbiome-dependent energy harvest to particular human gut microbiome compositions have been lacking. In this recently published study, we investigated whether energy extraction from the diet in 85 overweight adults, estimated by dry stool energy density, was associated with intestinal transit time and variations in microbial community diversity and structure. We found opposite of what we expected that stool energy density was positively associated with intestinal transit time. Furthermore, individuals with a Bacteroides enterotype (B-type) had significantly lower energy left in faeces (per gram dried faeces) compared to individuals with a Ruminococcaecea enterotype (R-type). The B-type individuals had lower alpha-diversity and faster intestinal transit time, but also a significantly higher body weight compared to the R-type individuals. Furthermore, markers of proteolytic fermentation were increased in the R-type compared to the B-type. Together, this could suggest that human gut microbiome-dependent energy extraction is diversified according to intestinal transit time and gut microbiome ecosystem variations as reflected by enterotypes. While the causalities remain to be established, the observations are intriguing and could provide new dietary strategies in body weight management. Link to OA paper: https://microbiomejournal.biomedcentral.com/articles/10.1186/s40168-022-01418-5https://cassyni-user-files-prod.s3.amazonaws.com/PvqMM9SavKnEBSjBx4gMMY https://cassyni.com/slides/outline/N5nsiXEq7L21qdK1rC8cXX https://cassyni.com/events/N5nsiXEq7L21qdK1rC8cXX/abstract https://cassyni-user-files-prod.s3.amazonaws.com/M5oH5HoZxyQdGTW5pKVa86 https://cassyni.com/events/N5nsiXEq7L21qdK1rC8cXX?videoPreview=1 A three strain postbiotic mix improves the immune system function after oral intake for 28-daysnohttps://cassyni.com/events/N5nsiXEq7L21qdK1rC8cXX?videoPreview=12024-03-20T11:00:00+00:0059.92Microbiome Virtual International Forum Background: Dietary selenium complements are known to improve overall health and enhance different aspects of the immune response, participating in the function of the immune cells, cytokine secretion regulation of chronic inflammation and control of excessive immune responses. In this study, our objective was to evaluate whether a selenium-rich postbiotic composed of whole-cell Saccharomyces cerevisiae ABB S12, Kluyveromyces marxianus ABB S8 and Saccharomyces boulardii ABB S3 yeast strains, can act as provider of selenium to enhance the function of the human immune system after oral intake. Methods and findings: A total of 15 volunteers were enrolled in a 28-day clinical study in which they complemented their normal diets with a daily dose of a novel selenium food supplement, “postbiotic immune”. Selenium levels in plasma were quantified by ELISA (Enzyme Linked Immuno Sorbent Assay), and the proliferation and activation of different subsets of lymphocytes isolated from PBMC’s (Peripheral Blood Mononuclear Cells) were assessed by flow cytometry using different cell markers. At the end of the study, we observed a higher proliferative capacity of total lymphocytes and specifically, of CD16+ lymphocytes (natural killer cells), upon stimulation with the CD3 and CD28 antibodies mimicking cell activation in vitro. Interestingly, we did not observe an increase in the activation of the lymphocyte subsets CD4+ (T helper cells) but CD16+, indicating that that there was a specific activation of natural killer cells. Conclusions: Altogether, our results suggest that orally ingested ”Postbiotic immune” primes the human immune system to elicit a faster and more efficient immune response through the specific activation of natural killer cells. Link to publication: https://nutraceuticals.imedpub.com/a-three-strain-postbiotic-mix-improves-the-immune-system-function-after-oral-intake-for-28days.php?aid=52017https://cassyni-user-files-prod.s3.amazonaws.com/M5oH5HoZxyQdGTW5pKVa86 https://cassyni.com/slides/outline/KcYrV71Cv3FUoU5EPQLFXK https://cassyni.com/events/KcYrV71Cv3FUoU5EPQLFXK/abstract https://cassyni-user-files-prod.s3.amazonaws.com/23XFRPBD8tZkiVPxHqsQyc https://cassyni.com/events/KcYrV71Cv3FUoU5EPQLFXK?videoPreview=1 Does genome contamination compromise the GTDB taxonomy?nohttps://cassyni.com/events/KcYrV71Cv3FUoU5EPQLFXK?videoPreview=12023-02-15T13:30:00+00:001657.36Microbiome Virtual International Forum Recently, the Bork group published a tool called GUNC (the Genome UNClutter) that detects chimerism and contamination in prokaryotic genomes. Disturbingly, they estimated that 3.2% (1009) of all species in release 95 of the Genome Taxonomy Database (GTDB) consist entirely of contaminated genomes, which could inflate estimates of phylogenetic diversity and taxonomic novelty. We applied GUNC to the latest release of GTDB and found the situation is even worse, with 6.0% (3,958) of all species in release 207 estimated to be comprised entirely of contaminated genomes. To address the question of whether this contamination compromises the GTDB taxonomy by inflating phylogenetic diversity, we split putative chimeric genomes into halves according to their GUNC contamination scores. We then inferred phylogenetic trees from the genome halves as per the standard GTDB workflow, i.e. based on a concatenated alignment of up to 120 single copy marker genes, to determine any changes in genus to phylum classifications between pairs of genome halves. We also subjected the genome halves to average nucleotide identity (ANI)-based analysis, which is how species are assigned in GTDB. These analyses allowed us to quantify taxonomic inflation caused by genomic contamination, and the extent to which the GTDB taxonomy has been compromised. Tune in to find out the results!https://cassyni-user-files-prod.s3.amazonaws.com/23XFRPBD8tZkiVPxHqsQyc https://cassyni.com/slides/outline/XxkxeCBKtV6Lh9K3MktyfT https://cassyni.com/events/XxkxeCBKtV6Lh9K3MktyfT/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Ne9uZ61bRAJRmyy4fFsaHk https://cassyni.com/events/XxkxeCBKtV6Lh9K3MktyfT?videoPreview=1 Effects of donor-engrafted clonal hematopoiesis in stem cell transplantationnohttps://cassyni.com/events/XxkxeCBKtV6Lh9K3MktyfT?videoPreview=12024-10-16T12:00:00+00:00211.08Bone Marrow TransplantationDonor stem cell health may be critically important to the success of hematopoietic stem cell transplantation (HSCT). Herein, we performed this systematic review and meta-analysis including meta-regression to assess the impacts of donor-engrafted clonal hematopoiesis (CH) in allogeneic HSCT (allo-HSCT) and of pre-transplant CH in autologous HSCT (auto-HSCT). We applied random effects models to analyze 5 allo-HSCT studies with 3192 donor-recipient pairs and 9 auto-HSCT studies with 2854 patients. We found that donor-engrafted CH after allo-HSCT decreased the risk of disease relapse [Hazard Ratio (HR) = 0.79, 95% Confidence Interval (CI): (0.67, 0.93)], but did not affect overall survival (OS) [HR = 0.91, 95% CI: (0.75, 1.11)], progression-free survival (PFS) [HR = 0.94, 95% CI: (0.63, 1.41)], or non-relapse mortality [HR = 1.06, 95% CI: (0.81, 1.39)]. In contrast, pre-transplant CH in auto-HSCT recipients resulted in inferior OS [HR = 1.30, 95% CI: (1.16, 1.46)], inferior PFS [HR = 1.35, 95% CI: (1.18, 1.54)], and higher risk for therapy-related myeloid neoplasm [HR = 4.85, 95% CI: (2.39, 9.82)] when compared to auto-HSCT recipients without CH. This study sheds light onto the debate about prospective “CHIP screening” for stem cell donors and addresses the impact of CH as a transmissible phenomenon.https://cassyni-user-files-prod.s3.amazonaws.com/Ne9uZ61bRAJRmyy4fFsaHk https://cassyni.com/slides/outline/YT8LYafzJLPAuMe91ch5tq https://cassyni.com/events/YT8LYafzJLPAuMe91ch5tq/abstract https://cassyni-user-files-prod.s3.amazonaws.com/LdtNUqtt3hMC9VA7xvmjcz https://cassyni.com/events/YT8LYafzJLPAuMe91ch5tq?videoPreview=1 Dynamics of Nonlinear Beams with Shear Thickening Fluid Supportsnohttps://cassyni.com/events/YT8LYafzJLPAuMe91ch5tq?videoPreview=12025-06-24T10:00:00+00:00672.76NODYSThis study explores the dynamic behavior of nonlinear beams supported by shear thickening fluid (STF), known for their non-Newtonian properties, where viscosity increases with applied force. We investigate how STF supports affect the dynamic characteristics of nonlinear beams, focusing on frequency responses, energy dissipation, and chaotic behavior in nonlinear regimes. Combining theoretical modeling and experimental analysis, we analyzed our investigated system and observe STF force responses under dynamic loading. Key findings reveal that STF supports introduce complex nonlinear dynamics, enhance vibration control, and exhibit chaotic behavior in certain excitation regimes, making them valuable for advanced structural applications.https://cassyni-user-files-prod.s3.amazonaws.com/LdtNUqtt3hMC9VA7xvmjcz https://cassyni.com/slides/outline/R3QGrKy7iU5f9KTETT5TSm https://cassyni.com/events/R3QGrKy7iU5f9KTETT5TSm/abstract https://cassyni-user-files-prod.s3.amazonaws.com/9H16XkXhMXYzZroTgoRzzr https://cassyni.com/events/R3QGrKy7iU5f9KTETT5TSm?videoPreview=1 Prediction-based Pole-placement Control for the Nanopositioning Systemnohttps://cassyni.com/events/R3QGrKy7iU5f9KTETT5TSm?videoPreview=12025-06-24T10:00:00+00:00964.68NODYSNanopositioning systems are challenging to control due to their sensitivities. A review of the literature reveals that time-delay is often overlooked in modeling or control of nanopositioners. Consequently, this research focuses on a prediction-based pole-placement controller for a nanopositioning system with an input delay. The controller incorporates both feedforward and feedback control laws, ensuring precise tracking of reference signals while compensating for time-delay effects. The closed-loop transfer function is formulated as a Butterworth filter to ensure the desired tracking performance. Simulation results demonstrate the controller’s ability to achieve zero steady-state error and stable tracking of the unit-step reference signal, with a significant increase in ±3dB bandwidth and a reduced settling time, compared to existing controllers. These findings confirm the controller’s potential for enhancing the performance of high-precision nanopositioning applications.https://cassyni-user-files-prod.s3.amazonaws.com/9H16XkXhMXYzZroTgoRzzr https://cassyni.com/slides/outline/TWeJ5kCjukr9WFvo18z6Ah https://cassyni.com/events/TWeJ5kCjukr9WFvo18z6Ah/abstract https://cassyni-user-files-prod.s3.amazonaws.com/FT79cJ7kqkUDUCzN42Caog https://cassyni.com/events/TWeJ5kCjukr9WFvo18z6Ah?videoPreview=1 Transient Rotordynamic Modelling using Pseudo Spectral Method with Experimental Validation on an Overhung Rotornohttps://cassyni.com/events/TWeJ5kCjukr9WFvo18z6Ah?videoPreview=12025-06-24T11:00:00+00:00674.0NODYSA high-speed spin test rig is employed for fault detection in rotating components prior to use in cryogenic engine turbopumps. The experimental studies include dynamic testing of an overhung rotor up to 36,000 RPM in the rig. The rig is supported by a pair of hybrid angular contact ball bearings provided with a spring pre-load. The stiffness of the ball bearings as well as the pre-load springs are measured experimentally. Damping is provided by a pair of oil-filled damper seals. Two orthogonally placed displacement sensors measure the rotor displacement and aid in detecting the critical speed transition. For determining the stiffness and damping coefficients of the damper seals, Pseudo Spectral Method (PSM), a semi-analytical technique, is employed to discretize and solve the nonlinear Reynolds lubrication equation to obtain the fluid pressure profile. The method is well validated with literature and offers a faster and more accurate convergence than FEM due to the use of global basis functions. Transient rotordynamic analysis performed with Timoshenko beam elements and Newmark-beta numerical integration scheme indicated good match between the prediction and experiments.https://cassyni-user-files-prod.s3.amazonaws.com/FT79cJ7kqkUDUCzN42Caog https://cassyni.com/slides/outline/8FMjH5yGnuFGjftJ5qPnUV https://cassyni.com/events/8FMjH5yGnuFGjftJ5qPnUV/abstract https://cassyni-user-files-prod.s3.amazonaws.com/APThtHjdLooG1JUgkMyv1C https://cassyni.com/events/8FMjH5yGnuFGjftJ5qPnUV?videoPreview=1 Suppression of parametric resonance using parametric force in a Hyperloop systemnohttps://cassyni.com/events/8FMjH5yGnuFGjftJ5qPnUV?videoPreview=12025-06-24T11:00:00+00:00586.04NODYSIn this work, we investigate the parametric resonance in a simplified model of a Hyperloop vehicle, arising from the interaction between electromagnetic and aeroelastic forces. Parametric resonance is analyzed using Floquet theory and Hill's determinant method. A key finding is that a linear, state-dependent parametric force can either suppress or amplify the parametric resonance induced by another state-dependent force by adjusting the amplitude of the parametric force.https://cassyni-user-files-prod.s3.amazonaws.com/APThtHjdLooG1JUgkMyv1C https://cassyni.com/slides/outline/G9m28eqZDb2w3iQGqpNV4h https://cassyni.com/events/G9m28eqZDb2w3iQGqpNV4h/abstract https://cassyni-user-files-prod.s3.amazonaws.com/YTw3evXtA2kTHqa7gPcRqg https://cassyni.com/events/G9m28eqZDb2w3iQGqpNV4h?videoPreview=1 Collisionless conduction in a high-beta plasma: a collision operator for whistler turbulencenohttps://cassyni.com/events/G9m28eqZDb2w3iQGqpNV4h?videoPreview=12025-01-30T16:00:00+00:003140.2Journal of Plasma PhysicsIn this talk, I will discuss the regulation of electron heat transport in high-beta, weakly collisional, magnetized plasma. A temperature gradient oriented along a mean magnetic field can induce a kinetic heat-flux-driven whistler instability (HWI), which back-reacts on the transport by scattering electrons. Previous analytical and numerical studies have shown that the heat flux for the saturated HWI scales as the inverse of the electron plasma beta. These numerical studies, however, had limited scale separation and consequently large fluctuation amplitudes, which calls into question their relevance at astrophysical scales. To this end, I will present a series of particle-in-cell simulations of the HWI across a range of electron plasma beta and temperature-gradient length scales under two different physical setups. The saturated heat flux in all of the simulations follows the expected electron-beta scaling, supporting the robustness of the result. I will also present several methods used to construct an effective collision operator for whistler turbulence from the simulation results. The collision operators obtained point to an issue with the standard quasi-linear explanation of HWI saturation, which is analogous to the well-known 90-degree scattering problem in the cosmic ray community. Despite this limitation, the methods developed here can serve as a blueprint for future work seeking to characterize the effective collisionality caused by kinetic instabilities.https://cassyni-user-files-prod.s3.amazonaws.com/YTw3evXtA2kTHqa7gPcRqg https://cassyni.com/slides/outline/AidNd8inPYwrerA3EuNh5F https://cassyni.com/events/AidNd8inPYwrerA3EuNh5F/abstract https://cassyni-user-files-prod.s3.amazonaws.com/TXT1C64dmTDRtjrmfuuS7Y https://cassyni.com/events/AidNd8inPYwrerA3EuNh5F?videoPreview=1 Monofractality in the Solar Wind at Electron Scales: Insights from Kinetic Alfvén Waves Turbulencenohttps://cassyni.com/events/AidNd8inPYwrerA3EuNh5F?videoPreview=12024-08-08T15:00:00+00:001769.0Journal of Plasma PhysicsThe breakdown of scale invariance in turbulent flows, known as multifractal scaling, is considered a cornerstone of turbulence. In solar wind turbulence, a monofractal behavior can be observed at electron scales, in contrast to larger scales where multifractality always prevails. Why scale invariance appears at electron scales is a challenging theoretical puzzle with important implications for understanding solar wind heating and acceleration. We investigate this long-standing problem using direct numerical simulations of three-dimensional electron reduced magnetohydrodynamics. Both weak and strong kinetic Alfvén waves turbulence regimes are studied in the balanced case. After recovering the expected theoretical predictions for the magnetic spectra, a higher-order multiscale statistical analysis is performed. This study reveals a striking difference between the two regimes, with the emergence of monofractality only in weak turbulence, whereas strong turbulence is multifractal. This result, combined with recent studies, shows the relevance of collisionless weak KAW turbulence to describe the solar wind at electron scales.https://cassyni-user-files-prod.s3.amazonaws.com/TXT1C64dmTDRtjrmfuuS7Y https://cassyni.com/events/BDGyfpNJq1VuecgvqLfVLZ/abstract https://cassyni-user-files-prod.s3.amazonaws.com/N6KMgZwrwR82mLGyfHfYAA https://cassyni.com/slides/outline/MavHkoUDSz44KbgU91Ypeh https://cassyni.com/events/MavHkoUDSz44KbgU91Ypeh/abstract https://cassyni-user-files-prod.s3.amazonaws.com/LXC47soXk1njq9J78jQkm4 https://cassyni.com/events/MavHkoUDSz44KbgU91Ypeh?videoPreview=1 Quantum computing for plasma physics: An overview of recent progressnohttps://cassyni.com/events/MavHkoUDSz44KbgU91Ypeh?videoPreview=12022-09-15T15:00:00+00:003849.28Journal of Plasma PhysicsQuantum computing (QC) promises to bring game changing capabilities. However, the potential for quantum speedup of plasma problems remains unclear. This colloquium surveys recent progress on applying QC to plasma related problems. To connect plasma physics with quantum hardware, both top-down and bottom-up approaches have yielded interesting results. The top-down approach starts from future ideal computers and reconceptualizes plasma problems to fit into the QC framework. The bottom-up approach starts from near-term noisy devices and builds up toy problems towards more realistic applications. The research field is still in its early stage, and wide gaps remain to be bridged before QC will become useful for plasma physics.https://cassyni-user-files-prod.s3.amazonaws.com/LXC47soXk1njq9J78jQkm4 https://cassyni.com/events/J8P4S1wYNnBRHuNuVMAs7s/abstract https://cassyni-user-files-prod.s3.amazonaws.com/H9qKDjUcYqb1NEZdeoxYS2 https://cassyni.com/slides/outline/Lbd5fSBAa4wueqrU335Vqo https://cassyni.com/events/Lbd5fSBAa4wueqrU335Vqo/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Kd5LT9iEk8MVjB3CCVsB9x https://cassyni.com/events/Lbd5fSBAa4wueqrU335Vqo?videoPreview=1 Plasma Modelling in Support of the STEP Fusion Reactor Programmenohttps://cassyni.com/events/Lbd5fSBAa4wueqrU335Vqo?videoPreview=12021-03-04T16:00:00+00:003012.8Journal of Plasma PhysicsSTEP – the Spherical Tokamak for Electricity Production – aims to deliver a prototype power plant by 2040 that will deliver net electricity at the 100MW level. This is a challenging timescale, that will require disruptive changes to how we design and regulate. The plasma scenario presents some of the biggest challenges, and this talk will discuss some of them. A spherical tokamak plasma has some advantages over one at conventional aspect ratio, allowing access to high elongation and beta (ratio of thermal plasma pressure to magnetic field pressure), in a compact geometry. Therefore, while much of the physics in the two designs is similar, there are also key differences. For example, the compact nature means there is little space for a solenoid, so non-inductive current drive is essential; the low magnetic field and high density require novel radio frequency methods for this current drive; the high beta affects the micro-instabilities that drive plasma turbulence and influence confinement; magnetohydrodynamic instabilities must be controlled to limit disruptions while achieving high fusion power and bootstrap current fraction; novel systems are required to manage the exhaust power loads, especially for the inner divertor leg. This talk will explore progress and challenges in modelling these key physics issues in support of STEP.https://cassyni-user-files-prod.s3.amazonaws.com/Kd5LT9iEk8MVjB3CCVsB9x https://cassyni.com/events/UzeMT4B62rMtpBCw6tQZ4h/abstract https://cassyni-user-files-prod.s3.amazonaws.com/E4USRY1qNkwpNxKCRK6njY https://cassyni.com/slides/outline/XTtNgUQiE98PB7gVeaKBnd https://cassyni.com/events/XTtNgUQiE98PB7gVeaKBnd/abstract https://cassyni-user-files-prod.s3.amazonaws.com/PZzBHGQL8is1c5XzbzqFvN https://cassyni.com/events/XTtNgUQiE98PB7gVeaKBnd?videoPreview=1 Relativistic plasma physics and high field phenomena using intense lasersnohttps://cassyni.com/events/XTtNgUQiE98PB7gVeaKBnd?videoPreview=12021-12-16T16:00:00+00:003059.64Journal of Plasma PhysicsThe past two decades have witnessed the development of revolutionary light sources having the unprecedented ability to probe new physical regimes and control matter with atomic scale precision. The ongoing development of multi-Petawatt lasers around the world will allow exploration of fundamental yet unanswered questions regarding non-linear Quantum Electrodynamics in relativistic plasmas, including non-perturbative quantum radiation reaction and electron-positron pair production mechanisms. Further experiments enabled by such lasers will include pump-probe experiments using femtosecond x-rays as a probe of material dynamics on ultra-short timescales, the production of GeV ion beams, the generation of instabilities in electron-positron jets, the exploration of vacuum polarization effects, relativistic shocks and the production of “exotic” particles such as pions and muons. I will review recent advances in this field and also describe the new NSF funded ZEUS facility under construction at the Center for Ultrafast Optical Science (CUOS) at the University of Michigan. ZEUS will be a dual-beamline 3 PetaWatt laser system that will provide unique capabilities for research. This will be a new high power laser user facility for US scientists as well as for the wider international research community, and will have an open and transparent external review panel for facility access and 30 weeks per year dedicated to external user experiments. After completion in 2023, the ZEUS laser system will be the highest-power laser system in the US.https://cassyni-user-files-prod.s3.amazonaws.com/PZzBHGQL8is1c5XzbzqFvN https://cassyni.com/events/U1M9Mgt39wFk9RNvzuwEFo/abstract https://cassyni.com/events/6mUANJ4UHFSS1fPm8Mj66y/abstract https://cassyni.com/events/7G7mQyhzihzV1Rveio1tNH/abstract https://cassyni.com/slides/outline/BgtYVCx3N7n7sp8H2zrLvy https://cassyni.com/events/BgtYVCx3N7n7sp8H2zrLvy/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Cbx6a4vGXTDXjkQfZqjgxW https://cassyni.com/events/BgtYVCx3N7n7sp8H2zrLvy?videoPreview=1 Intraoperative Neuromonitoring for Neuroprotection during Cryoablation of Pediatric Vascular Anomalies and Hypovascular Massesnohttps://cassyni.com/events/BgtYVCx3N7n7sp8H2zrLvy?videoPreview=12025-10-16T09:46:44+00:00596.56Society for Pediatric Interventional Radiology## Introduction Cryoablation is a minimally invasive therapy for sclerotherapy-resistant venous malformations and hypovascular masses, but nerve proximity risks iatrogenic injury, limiting treatment to lesions >5 mm from nerves1. Intraoperative Neuromonitoring (IONM) during cryoablation may assuage this limitation, particularly for deep or unresectable lesions2. This study evaluates free-run EMG monitoring along with sensory monitoring in preventing nerve injury during pediatric percutaneous cryoablation, assessing procedural safety. ## Materials and Methods A retrospective study at a tertiary care academic medical children’s hospital was performed following IRB approval. Cases in which cryoablation was used in conjunction with IONM were reviewed. Demographic and baseline patients’ characteristics were extracted in addition to procedural details, including cryoablation and IONM (free run EMG, MEP, SSEP, TOF). Follow-up clinical and imaging data were also reviewed using simple summative statistics. ## Results Six cryoablation sessions were performed in four patients (three male, one female; median age: 16). Lesions included desmoid tumors (n = 2), neurofibroma (n = 1), and vascular malformations (n = 1). Technical success of cryoablation was achieved in 100%, with transient EMG amplitude reductions (>50%) during ice-ball formation in 1 case, prompting real-time probe adjustment. No permanent deficits occurred. Symptom improvement was observed in 100% of cases, accompanied by a qualitative reduction in size on follow-up imaging. Minor adverse events included transient sensory deficit around the area of malformation, which was resolved within a few weeks. ## Discussion IONM offered benefits as a modality of neurosurveillance during cryoablation to maximize the treatment zone while mitigating the risk of neuro-injury. Future refinements of preferred IONM techniques can be considered.https://cassyni-user-files-prod.s3.amazonaws.com/Cbx6a4vGXTDXjkQfZqjgxW https://cassyni.com/slides/outline/Fdpmq1VGFXsMwRDZYBrac5 https://cassyni.com/events/Fdpmq1VGFXsMwRDZYBrac5/abstract https://cassyni-user-files-prod.s3.amazonaws.com/QZPckvCx8eM8gBzL1mr4Ge https://cassyni.com/events/Fdpmq1VGFXsMwRDZYBrac5?videoPreview=1 Zoonotic Disease Risks at Traditional Food Marketsnohttps://cassyni.com/events/Fdpmq1VGFXsMwRDZYBrac5?videoPreview=12026-01-29T10:00:00+00:003310.68Journal of VirologyJoin us for the next JVI Seminar Series webinar where Frida E. Sparaciari, PhD, presents on the zoonotic disease risks associated with traditional food markets (TFMs). This webinar explores how TFMs support millions of livelihoods and remain essential to daily life in many regions. However, this dynamic also brings humans, animals, and the environment into close contact, creating opportunities for zoonotic pathogens to emerge and spread. This webinar unpacks what current evidence tells us about these risks and highlights how targeted surveillance and One Health strategies can help make these markets safer while preserving their cultural and economic value. Learning Objectives: • Understand how TFM practices and systems contribute to disease emergence and transmission. • Understand the role of zoonotic pathogens and risk factors present in TFMs. • Learn how environmental surveillance and One Health approaches can help detect and reduce zoonotic diseases risks.https://cassyni-user-files-prod.s3.amazonaws.com/QZPckvCx8eM8gBzL1mr4Ge https://cassyni.com/events/K79SMRSkbqgmBayHAXonvy/abstract https://cassyni-user-files-prod.s3.amazonaws.com/7CzJSBYk6zMCvrX4gKZc2z https://cassyni.com/slides/outline/R2AspdJ7zbKggBif9bWh5F https://cassyni.com/events/R2AspdJ7zbKggBif9bWh5F/abstract https://cassyni-user-files-prod.s3.amazonaws.com/4bgQJNCuhYfecbyKfjWjrv https://cassyni.com/events/R2AspdJ7zbKggBif9bWh5F?videoPreview=1 Plant life in a hotter planet: can they manage alone?nohttps://cassyni.com/events/R2AspdJ7zbKggBif9bWh5F?videoPreview=12026-06-05T09:00:00+00:002151.56Plants detect heat through subtle changes in the fluidity of their cell membranes, which activate calcium ion channels, triggering a heat shock response within a matter of minutes. In a desperate race against time, the plant synthesizes protective proteins and metabolites such as proline to safeguard its molecular structures before extreme heat degrades its enzymes and halts photosynthesis. Physically, plants attempt to cool themselves by growing smaller, thinner leaves that dissipate heat more effectively or by sacrificing their water reserves to cool their surface through evaporation—a strategy that becomes suicidal when heat combines with drought. The impact of warming extends invisibly but lethally to pollinators, as heat waves degrade the nutritional quality of pollen and drastically reduce the nectar reward. This sort of heat-induced “junk food” triggers a collapse in the food web, where bee larvae consuming heat-stressed pollen suffer massive mortality and surviving adults see their lifespans drastically shortened. Global warming disrupts the delicate balance of the soil microbiome that interacts with plants, sometimes turning former bacterial allies into opportunists or facilitating the invasion of pathogens that take advantage of the plant’s suppressed immune system under extreme conditions. In response to this crisis, some plants have evolved a chemical distress signal mechanism through their roots to recruit specific soil microbes that can provide immediate resistance against heat stress. These biological interactions act as a determining factor that can either mitigate or amplify the impacts of climate change: while a diverse plant community can mitigate extreme heat by creating cooler, more humid microclimates, the loss of key symbionts or the emergence of new diseases can exacerbate the vulnerability of entire ecosystems. The survival of ecosystems and crops depends not only on the resilience of an isolated species, but on the integrity of a network of biological interactions that is now faltering under unprecedented warming.https://cassyni-user-files-prod.s3.amazonaws.com/4bgQJNCuhYfecbyKfjWjrv https://cassyni.com/slides/outline/2K8Wtoxo5dnULBCXQJCPqX https://cassyni.com/events/2K8Wtoxo5dnULBCXQJCPqX/abstract https://cassyni-user-files-prod.s3.amazonaws.com/M7UiiG6CXnS4fCSLnNb1Gz https://cassyni.com/events/2K8Wtoxo5dnULBCXQJCPqX?videoPreview=1 Twisted metamaterials for phononic wavesnohttps://cassyni.com/events/2K8Wtoxo5dnULBCXQJCPqX?videoPreview=12023-01-31T14:00:00+00:004208.08MetaMATFor the last two decades, metamaterials and metasurfaces have been extensively studied in order to induce extreme anisotropic behaviors such has hyperbolic propagation of waves. Such peculiar systems allow highly precise and tunable manipulation of the field in two or three dimensions. At the same time, moiré super-lattices and the rapidly expanding domain of twistronics in solid-state physics have provided new phase transitions phenomena such as flat band superconductivity for example. Inspired by these exciting new ideas, we implement macroscopic wave twistronics analogues to harness these new features in the context of enhanced wave manipulation. In particular, in this talk we present the cases of phononic hyperbolic metamaterials and metasurfaces and how they behave in presence of the symmetry breaking induced by a twist in the system. These results introduce some new opportunities provided by macroscopic wave twistronics with metamaterials, both from a fundamental and practical point of view. https://cassyni-user-files-prod.s3.amazonaws.com/M7UiiG6CXnS4fCSLnNb1Gz https://cassyni.com/slides/outline/Fedq9GRxvzjSDPW7ZXLiWH https://cassyni.com/events/Fedq9GRxvzjSDPW7ZXLiWH/abstract https://cassyni-user-files-prod.s3.amazonaws.com/XimtaUebhq2sJh1vNDRZw4 https://cassyni.com/slides/outline/GeKkqSwRSxorHaC2TVM1wb https://cassyni.com/events/GeKkqSwRSxorHaC2TVM1wb/abstract https://cassyni-user-files-prod.s3.amazonaws.com/5Sc5dR4vy339hYxFzgm3Qr https://cassyni.com/events/GeKkqSwRSxorHaC2TVM1wb?videoPreview=1 Can high-fidelity simulations and machine-learning impact gas turbine component design?nohttps://cassyni.com/events/GeKkqSwRSxorHaC2TVM1wb?videoPreview=12022-11-30T14:00:00+00:003327.04Department of AeronauticsCFD predictions are becoming increasingly important in the design of gas turbine components because correlation-based methods are unable to further improve efficiency and laboratory experiments with the required fidelity are prohibitively expensive. Although first-principles based simulations are most accurate, the excessive computational cost preclude their use in a design context and therefore modelling is required. However, the inaccuracies introduced by RANS- or URANS-based CFD approaches limits the impact CFD can have on technology development. This presentation will show how physical insight relevant to designers has been extracted from high-fidelity simulations of gas turbine blades and stages. It will also discuss some of the inherent turbulence modelling errors and how those can be addressed with a novel machine-learning approach that uses high-fidelity data. It will be shown that closure models developed using the gene-expression programming approach outperform traditional models both for the cases they were trained on and for cases not seen before. https://cassyni-user-files-prod.s3.amazonaws.com/5Sc5dR4vy339hYxFzgm3Qr https://cassyni.com/slides/outline/BhqiNcUB4PGptUUgT1e2DT https://cassyni.com/events/BhqiNcUB4PGptUUgT1e2DT/abstract https://cassyni-user-files-prod.s3.amazonaws.com/VJC3JqXaiEkdptWPemvQAr https://cassyni.com/events/BhqiNcUB4PGptUUgT1e2DT?videoPreview=1 Interaction between a synthetic jet and turbulent boundary layers: Experiments and Modelsnohttps://cassyni.com/events/BhqiNcUB4PGptUUgT1e2DT?videoPreview=12022-04-26T14:00:00+00:001737.84Experiments in FluidsSynthetic jet (or zero mass-flux) actuators have been used in a various flow control strategies ranging from separation control to reduction of skin-friction drag. In most of these applications, it is crucial to understand the interaction between the jet and the incoming turbulent boundary layer as well as model the trajectory of the jet in cross flow. In this talk, Prof. Ganapathisubraniam will present some results where the interaction between a synthetic jet and turbulent boundary layers is examined is detailed. Experiments are carried out to measure the flowfield and the evolution of the interaction with downstream distance is documented. The experimental data is then used to develop data-driven models that can be used to predict this interaction across a range of synthetic jet parameters. In addition to predicting some aspects of the interaction, these models also allow scientists to develop further understanding of the interaction and to isolate the specific effects of the jet (such as viscous effect or vortical effect) on the boundary layer.https://cassyni-user-files-prod.s3.amazonaws.com/VJC3JqXaiEkdptWPemvQAr https://cassyni.com/events/Q3dUpFuzzRDnaggdB1Wnf7/abstract https://cassyni-user-files-prod.s3.amazonaws.com/6qW6efp6mtwBMLJxDGZwQa https://cassyni.com/slides/outline/JcVqJjoEAP8iBpSPa6Wzff https://cassyni.com/events/JcVqJjoEAP8iBpSPa6Wzff/abstract https://cassyni-user-files-prod.s3.amazonaws.com/DgSQ1jtUfS6ZzFTAurLKi6 https://cassyni.com/events/JcVqJjoEAP8iBpSPa6Wzff?videoPreview=1 Development of a Combustion Module within the Nektar++ Frameworknohttps://cassyni.com/events/JcVqJjoEAP8iBpSPa6Wzff?videoPreview=12022-09-14T08:00:00+00:001657.4NEKTAR++In this project combustion modelling methods will be implemented into the framework of Nektar++, a spectral/hp element solver. The aim is to create a reactive multiphase flow solver capable of accurately modelling combustion flow regimes at low Mach numbers. To date, a pseudo-compressible multiphase flow solver has been developed based on the Incompressible Navier-Stokes code provided by Nektar++. The solver uses a low Mach variable density approach, able to simulate mixing between fuel and oxidizer phases. Validations have been performed with a canonical turbulent flow case and combustor relevant geometry such as cold flow of Sandia Piloted CH4/Air Flames. Simulations are LES, polynomial order 4, and have been completed using Lovelace and Sulis. For modelling of reactive flow, a 1D flamelet generated manifold (FGM) formulation dependant on mixture fraction, Z, is currently in development. Further FGM expansion is expected to include dependences on the variance of mixture fraction, Z’’, and if time permits, the progress variable, c, and its variance, c’’. The completed solver will be validated with canonical flame datasets and assessed against relatively ‘low’ and ‘high’ order reacting flow codes. Subsequently, the developed program will be applied to setups that are more representative of future combustors.https://cassyni-user-files-prod.s3.amazonaws.com/DgSQ1jtUfS6ZzFTAurLKi6 https://cassyni.com/slides/outline/7kEYHhZgWJwmuLz8oYN1v5 https://cassyni.com/events/7kEYHhZgWJwmuLz8oYN1v5/abstract https://cassyni-user-files-prod.s3.amazonaws.com/CEpM995vBAmUM7nDEZ9BZQ https://cassyni.com/events/7kEYHhZgWJwmuLz8oYN1v5?videoPreview=1 Experimental Simulation of Gust – Wing Interactionsnohttps://cassyni.com/events/7kEYHhZgWJwmuLz8oYN1v5?videoPreview=12022-11-08T15:00:00+00:003158.36Experiments in FluidsExperimental simulation of gusts presents several challenges: difficulty of producing gusts to compare with theory/computational simulations and lack of two-dimensionality of the gusts. We have investigated gusts generated by oscillating airfoils and used measurements of spanwise and streamwise two-point correlations to characterize the gusts. The spanwise coherence of unsteady wake of a periodically plunging airfoil has been studied. The results indicate that the Strouhal number is the most important parameter that determines the degree of two-dimensionality of the wake. The implications of these findings for experimental gust generators using oscillating airfoils have been discussed. A method to produce single vortical gust has been developed. A nearly two-dimensional vortex of small core size can be generated by the transient plunging motion of an upstream airfoil. In a parallel effort, a novel gust generator has been developed, which does not rely on the vortical shear flows that suffer from three-dimensional instabilities. This has been achieved by oscillating a small fence on the wind tunnel wall and deflecting the freestream periodically. Example of gust-wing interactions for downstream airfoils, unswept and swept wings will be illustrated, revealing the deformation of the incident gust, formation of a leading-edge vortex, and shedding. In general, lift change during the gust encounter is much larger for separated wing flows than for attached flows.https://cassyni-user-files-prod.s3.amazonaws.com/CEpM995vBAmUM7nDEZ9BZQ https://cassyni.com/slides/outline/4HhJxv31S758sega9sz4PF https://cassyni.com/events/4HhJxv31S758sega9sz4PF/abstract https://cassyni-user-files-prod.s3.amazonaws.com/MU4oSczYwdqRcJDv4U1ahU https://cassyni.com/events/4HhJxv31S758sega9sz4PF?videoPreview=1 Coating Liquid Films down a Vertical Fibrenohttps://cassyni.com/events/4HhJxv31S758sega9sz4PF?videoPreview=12021-05-07T15:00:00+00:001187.6Journal of Fluid MechanicsPrevious experimental study by Kliakhandler et al. (JFM 429:381-390, 2001) reported three different flow patterns of a liquid film flowing down a vertical cylinder. The film flow is unstable due to the famous Plateau-Rayleigh mechanism, which evolves into organised droplets flow patterns. When the flow rate is high, steady moving droplets separated by a long-thin film were observed. When the flow rate is reduced, necklace-like flow structure was seen. When the flow rate is very small, droplets of multi-scales were observed and complex dynamical interactions between these droplets cause an unsteady flow. However, no previous theoretical model correctly predicted the droplet dynamics in the three regimes. In this talk, I will discuss the reasons accounting for poor predictions of liquid film dynamics down a vertical fibre. Then, we solve the Navier-Stokes problem and our results show excellent agreements with the experimental data by Kliakhandler et al.https://cassyni-user-files-prod.s3.amazonaws.com/MU4oSczYwdqRcJDv4U1ahU https://cassyni.com/slides/outline/EfJzwGd2eihZQ9yiAyvx4m https://cassyni.com/events/EfJzwGd2eihZQ9yiAyvx4m/abstract https://cassyni-user-files-prod.s3.amazonaws.com/2YNPCBteqfzNUyCCuYxyBt https://cassyni.com/slides/outline/F9xbyxGZ6BFcPvWbmRDkL5 https://cassyni.com/events/F9xbyxGZ6BFcPvWbmRDkL5/abstract https://cassyni-user-files-prod.s3.amazonaws.com/BayKJrxdfU4D2sRbDpnuk https://cassyni.com/events/F9xbyxGZ6BFcPvWbmRDkL5?videoPreview=1 On the response of lossy two-phase materials subject to time-varying fieldsnohttps://cassyni.com/events/F9xbyxGZ6BFcPvWbmRDkL5?videoPreview=12022-07-05T15:40:00+00:001257.04ETOPIMIn this talk, we will discuss bounds on the quasistatic response of lossy two-phase materials when subject to applied electromagnetic fields (or antiplane elastic fields), that can have any variation in time, not necessarily a fixed frequency one. Interestingly enough, appropriate choices of the applied field can directly provide the volume fractions of the phases from measurements at specific times. Here we will show how to tailor the applied fields in order to obtain such a result.https://cassyni-user-files-prod.s3.amazonaws.com/BayKJrxdfU4D2sRbDpnuk https://cassyni.com/slides/outline/9ipxUS9nG9AY14GNAWDxLd https://cassyni.com/events/9ipxUS9nG9AY14GNAWDxLd/abstract https://cassyni-user-files-prod.s3.amazonaws.com/RsR7EGPb7yh6onYRjwWuxr https://cassyni.com/events/9ipxUS9nG9AY14GNAWDxLd?videoPreview=1 Molecular chirality sensing via parity-time symmetric and general loss-gain systemsnohttps://cassyni.com/events/9ipxUS9nG9AY14GNAWDxLd?videoPreview=12022-07-07T14:30:00+00:001806.04ETOPIMWe discuss the potential of combined gain-loss systems, and in particular of parity-time symmetric (PT) systems, to enhance the chiral response of embedded molecular chiral systems, facilitating thus chirality sensing and enantiomer discrimination. Thin molecular chiral layers embedded in properly designed PT-symmetric systems have been found to lead to more than one order of magnitude enhancement of both the attainable circular dichroism (CD) response and the Kuhn’s dissymmetry factor, the latter directly related to the enantio-selectivity of chiral light-matter interactions.https://cassyni-user-files-prod.s3.amazonaws.com/RsR7EGPb7yh6onYRjwWuxr https://cassyni.com/events/N54gk9qndww83DCaRRj87P/abstract https://cassyni-user-files-prod.s3.amazonaws.com/ARpWAMEoa6HKphdaDGNp1C https://cassyni.com/slides/outline/QYJhya5QqEhcQ9g8y7dkqK https://cassyni.com/events/QYJhya5QqEhcQ9g8y7dkqK/abstract https://cassyni-user-files-prod.s3.amazonaws.com/NprDKW2F9eMhD1nUThG2hL https://cassyni.com/events/QYJhya5QqEhcQ9g8y7dkqK?videoPreview=1 Analytic solutions for flows through cascadesnohttps://cassyni.com/events/QYJhya5QqEhcQ9g8y7dkqK?videoPreview=12020-11-27T16:20:00+00:001127.12Journal of Fluid MechanicsMotivated by turbomachinery aeroacoustics, we investigate the flow through a periodic array of disconnected objects, termed a “cascade”. We deploy and develop techniques from complex analysis to elucidate the mathematical structures and physical mechanisms relevant to cascade flows. Our approach considers both aerodynamic and aeroacoustic aspects but we focus efforts toward developing conformal mapping techniques amenable to cascades of complicated geometry and topology. The foundation of practical conformal mapping is the Schwarz–Christoffel (SC) formula; we extend the SC formula to periodic domains which enables analytic constructions of the periodic flow field. By utilising tools from function theory, our solutions are valid for an arbitrary number of obstacles per period window.We also present algorithmic advances that enable rapid and accurate calculations of our mappings. Our theory is applied to classical idealised problems such as steady potential flows, unsteady vortex dynamics, and free-streamline flows. These low-order techniques can be used in turbomachinery design schemes or for real-time flow control with data-driven methods.https://cassyni-user-files-prod.s3.amazonaws.com/NprDKW2F9eMhD1nUThG2hL https://cassyni.com/events/H8aeHKNYFNQ6e7VEQx28PF/seminar/qa https://cassyni.com/slides/outline/H8aeHKNYFNQ6e7VEQx28PF https://cassyni.com/events/H8aeHKNYFNQ6e7VEQx28PF/abstract https://cassyni-user-files-prod.s3.amazonaws.com/RLpw19zhs7dArU5KyCZoNv https://cassyni.com/events/H8aeHKNYFNQ6e7VEQx28PF?videoPreview=1 Machine learning in plant–pathogen interactions: empowering biological predictions from field scale to genome scalenohttps://cassyni.com/events/H8aeHKNYFNQ6e7VEQx28PF?videoPreview=12022-12-07T09:00:00+00:002375.08New PhytologistMachine learning (ML) encompasses statistical methods that learn to identify patterns in complex datasets. Here, Jana reviews application areas in plant–pathogen interactions that have recently benefited from ML. She provides an under-the-hood glance into her developed suite of ML-based tools for pathogen effector prediction such as EffectorP. Jana will discuss common pitfalls and challenges she encountered during the development of ML approaches. Finally, she will highlight future opportunities for ML as a tool for dissecting plant–pathogen interactions, for example through integration of AlphaFold predictions or ML-driven effector gene annotation. Hosted by *New Phytologist* Editor Francis Martinhttps://cassyni-user-files-prod.s3.amazonaws.com/RLpw19zhs7dArU5KyCZoNv https://cassyni.com/slides/outline/Xx2mfpnHR71StjCbvzVVFK https://cassyni.com/events/Xx2mfpnHR71StjCbvzVVFK/abstract https://cassyni-user-files-prod.s3.amazonaws.com/4fGdp4huXYtEBfNRTpGyti https://cassyni.com/events/Xx2mfpnHR71StjCbvzVVFK?videoPreview=1 Advancing spectral/hp element high fidelity simulation of incompressible and compressible flowsnohttps://cassyni.com/events/Xx2mfpnHR71StjCbvzVVFK?videoPreview=12022-12-01T03:00:00+00:003615.64Mechanical EngineeringIntroduction: Advanced high order methods using Spectral/hp element discretization including Galerkin, Discontinuous Galerkin (DG) and Flux Reconstruction (FR) formulations are gaining notable interest in both the academic and industrial sectors. The compact nature of the approach is not only attractive from the perspective of implementation on modern computational hardware but also provides a consistent geometric and spatially localized accuracy unlike many high order finite volume methods. These features make the methodology attractive in complex geometry flows involving transitional and turbulent boundary layers demanding a high level of accuracy for high end engineering applications that commonly arise in the aeronautical sector. Aim & Scope: In this presentation, we will present our current work on developing and advancing spectral/hp element incompressible and compressible flow solvers for industry relevant, high fidelity applications. The demands of handling “industrial strength” complex geometries at high Reynolds numbers presents a number of challenges both in terms high order mesh generation, stabilization of marginally resolved flows and maintaining computational efficiency. In this presentation we will highlight our on-going efforts to address all of these challenges and demonstrate the suitability of the approach for a number of representative examples. https://cassyni-user-files-prod.s3.amazonaws.com/4fGdp4huXYtEBfNRTpGyti https://cassyni.com/slides/outline/T1YjCzK32XURVdVFvWnVXB https://cassyni.com/events/T1YjCzK32XURVdVFvWnVXB/abstract https://cassyni-user-files-prod.s3.amazonaws.com/CDwQqM325aUGhRccgcGjjC https://cassyni.com/events/T1YjCzK32XURVdVFvWnVXB?videoPreview=1 Regularity structures and machine learningnohttps://cassyni.com/events/T1YjCzK32XURVdVFvWnVXB?videoPreview=12022-01-13T16:00:00+00:003060.64DataSıgIn many machine learning tasks, it is crucial to extract low-dimensional and descriptive features from a data set. In this talk, I present a method to extract features from multi-dimensional space-time signals which is motivated, on the one hand, by the success of path signatures in machine learning, and on the other hand, by the success of models from the theory of regularity structures in the analysis of PDEs. I will present a flexible definition of a model feature vector along with numerical experiments in which we combine these features with basic supervised linear regression to predict solutions to parabolic and dispersive PDEs with a given forcing and boundary conditions. Interestingly, in the dispersive case, the prediction power relies heavily on whether the boundary conditions are appropriately included in the model. The talk is based on the following joint work with Andris Gerasimovics and Hendrik Weber: https://arxiv.org/abs/2108.05879https://cassyni-user-files-prod.s3.amazonaws.com/CDwQqM325aUGhRccgcGjjC https://cassyni.com/slides/outline/DBPourCLjhxwrT2Z1qS5nM https://cassyni.com/events/DBPourCLjhxwrT2Z1qS5nM/abstract https://cassyni-user-files-prod.s3.amazonaws.com/NNrzNFGsEXevBLso1RrS7Q https://cassyni.com/events/DBPourCLjhxwrT2Z1qS5nM?videoPreview=1 On Wasserstein projectionsnohttps://cassyni.com/events/DBPourCLjhxwrT2Z1qS5nM?videoPreview=12020-09-17T16:00:00+00:002938.04DataSıgWe study the minimum Wasserstein distance from the empirical measure to a space of probability measures satisfying linear constraints. This statistic can naturally be used in a wide range of applications, for example, optimally choosing uncertainty sizes in distributionally robust optimization, optimal regularization, testing fairness, martingality, among many other statistical properties. We will discuss duality results which recover the celebrated Kantorovich-Rubinstein duality when the manifold is sufficiently rich and associated test statistics as the sample size increases. We illustrate how this relaxation can beat the statistical curse of dimensionality often associated to empirical Wasserstein distances. The talk builds on joint work with S. Ghosh, Y. Kang, K. Murthy, M. Squillante, and N. Si.https://cassyni-user-files-prod.s3.amazonaws.com/NNrzNFGsEXevBLso1RrS7Q https://cassyni.com/slides/outline/pZnC1rvrG1WRhpEoCYo8h https://cassyni.com/events/pZnC1rvrG1WRhpEoCYo8h/abstract https://cassyni-user-files-prod.s3.amazonaws.com/RWsy5fvQW6LphVJ5kKkA62 https://cassyni.com/events/pZnC1rvrG1WRhpEoCYo8h?videoPreview=1 SLIPI-polarization ratio imaging: A new technique for sizing droplets in optically dense spraysnohttps://cassyni.com/events/pZnC1rvrG1WRhpEoCYo8h?videoPreview=12024-02-06T15:00:00+00:003009.12Experiments in FluidsPrevious research has shown that the polarization ratio technique allows sizing droplets generated from dilute spray systems. The polarization ratio technique is based on the acquisition of the perpendicular and parallel polarized components of Lorenz-Mie scattered light, which ratio is proportional to the surface mean diameter, D21. One of the main advantage of this technique, compared to some other laser imaging techniques (e.g. LIF/Mie droplet sizing), is that no fluorescent dye is required. This makes the technique suitable for the characterization of sprays under evaporating conditions. However, its application to optically dense sprays has posed significant challenges and restrictions due to the presence and detection of multiple light scattering. A novel approach, presented in this talk, consists in combining the polarization ratio approach with Structured Laser Illumination Planar Imaging - SLIPI - a technique that allows suppressing efficiently the unwanted multiple light scattering intensity. Thanks to this suppression of unwanted light, the method offers a promising solution for accurate and comprehensive 2D characterization of challenging atomizing sprays. Note that the SLIPI-polarization ratio technique is calibrated using Phase Doppler Anemometry and applied, here, to a hollow-cone water spray running from 20 and 100 bar injection pressure.https://cassyni-user-files-prod.s3.amazonaws.com/RWsy5fvQW6LphVJ5kKkA62 https://cassyni.com/events/4o6j6bbTkJdrVXnXNkWWyb/seminar/qa https://cassyni.com/slides/outline/4o6j6bbTkJdrVXnXNkWWyb https://cassyni.com/events/4o6j6bbTkJdrVXnXNkWWyb/abstract https://cassyni-user-files-prod.s3.amazonaws.com/3bYW3U1fSrn6RrahGtryEN https://cassyni.com/events/4o6j6bbTkJdrVXnXNkWWyb?videoPreview=1 Easy to gain but hard to lose: the evolution of the knee sesamoid bones in Primates—a systematic review and phylogenetic meta-analysisnohttps://cassyni.com/events/4o6j6bbTkJdrVXnXNkWWyb?videoPreview=12024-11-15T15:00:00+00:003223.28Royal Society PublishingSesamoids are variably present skeletal elements found in tendons and ligaments near joints. Variability in sesamoid size, location and presence/absence is hypothesized to enable skeletal innovation, yet sesamoids are often ignored. Three knee sesamoids—the cyamella, medial fabella and lateral fabella—are present in primates, but we know little about how they evolved, if they are skeletal innovations, or why they are largely missing from Hominoidea. Our phylogenetic comparative analyses suggest that sesamoid presence/absence is highly phylogenetically structured and contains phylogenetic signal. Models suggest that it is easy to gain but difficult/impossible to lose knee sesamoids and that the fabellae may have similar developmental/evolutionary pathways that are distinct from the cyamella. Sesamoid presence/absence is uncorrelated to the mode of locomotion, suggesting that sesamoid biomechanical function may require information beyond sesamoid presence, such as size and location. Ancestral state reconstructions were largely uninformative but highlighted how reconstructions using parsimony can differ from those that are phylogenetically informed. Interestingly, there may be two ways to evolve fabellae, with humans evolving fabellae differently from most other primates. We hypothesize that the ‘re-emergence’ of the lateral fabella in humans may be correlated with the evolution of a unique developmental pathway, potentially correlated with the evolution of straight-legged, bipedal locomotion.https://cassyni-user-files-prod.s3.amazonaws.com/3bYW3U1fSrn6RrahGtryEN https://cassyni.com/events/6H6nTuZosQ9bokeWSLYK6m/seminar/qa https://cassyni.com/slides/outline/6H6nTuZosQ9bokeWSLYK6m https://cassyni.com/events/6H6nTuZosQ9bokeWSLYK6m/abstract https://cassyni-user-files-prod.s3.amazonaws.com/WcsSy1KChS18PWyyiVQxNi https://cassyni.com/events/6H6nTuZosQ9bokeWSLYK6m?videoPreview=1 Rethinking extinction “crises”: The case of Asian songbird tradenohttps://cassyni.com/events/6H6nTuZosQ9bokeWSLYK6m?videoPreview=12025-05-01T13:00:00+00:001623.44Cambridge PrismsEnvironmental challenges are often described as ‘crises,’ which are difficult to resolve due to complex and contradictory evidence. This talk examines the crisis narrative of the IUCN-declared Asian Songbird Crisis (ASC) in Indonesia, where birdkeeping culture is prevalent. We explore how different actors, especially conservation law enforcement and practitioners, perceive bird extinction through interviews and focus groups. Our findings reveal diverse attitudes towards the ASC, with many law enforcement actors not recognizing the crisis label. Market dynamics shift harvesting pressure onto similar species, challenging the notion that species extinction significantly impacts wildlife trades. This study highlights the need for a shared language around species extinction and the implications of the ‘crisis’ label. This chapter is part of my broader PhD thesis, "Exploring Socio-Technological-Ecological Dimensions of Asian Songbird Trade." The thesis investigates the development of technological interventions for species identification in reducing illegal wildlife trade (IWT) and examines these technologies within their wider social, cultural, political, and legal contexts. While we demonstrate the proof of concept for species identification technology, we remain hesitant to endorse its deployment due to concerns about its efficacy, suitability, and ethical implications. Instead, we explore more sustainable and culturally sensitive trade strategies that may benefit wild populations of birds more effectively than increased law enforcement or demand reduction alonehttps://cassyni-user-files-prod.s3.amazonaws.com/WcsSy1KChS18PWyyiVQxNi https://cassyni.com/events/LbvvvMqv138uGQ6j981h1o/seminar/qa https://cassyni.com/slides/outline/LbvvvMqv138uGQ6j981h1o https://cassyni.com/events/LbvvvMqv138uGQ6j981h1o/abstract https://cassyni-user-files-prod.s3.amazonaws.com/D2eM9aV4KKXXgWQeDrswuY https://cassyni.com/events/LbvvvMqv138uGQ6j981h1o?videoPreview=1 JAX-Fluids: Toward Differentiable CFD of Compressible Single- and Two-phase Flowsnohttps://cassyni.com/events/LbvvvMqv138uGQ6j981h1o?videoPreview=12025-03-17T14:00:00+00:003564.64Computer Physics CommunicationsThis talk presents an overview of the automatically differentiable JAX-Fluids computational fluid dynamics (CFD) solver. JAX-Fluids is a high-order Godunov-type finite-volume solver for compressible single- and multi-phase flows. The solver is implemented using the JAX Python package which allows the computation of automatic differentiation (AD) gradients throughout the entire code framework. The present talk is structured into three parts. First, we discuss the numerical methods implemented in the JAX-Fluids solver, including the available two-phase models (i.e., a level-set based sharp-interface model and a five-equation diffuse-interface model). Second, we explore a JAX primitives-based parallelization strategy which scales effectively on GPU- and TPU-clusters while maintaining AD capabilities in distributed settings. In this section, we also highlight JAX-specific implementation aspects that are different from traditional HPC languages such as C++ or Fortran. Third, we showcase applications that combine high-order numerical methods with automatic differentiation. In particular, we demonstrate that JAX-Fluids allows the end-to-end optimization of numerical models and the solution of inverse problems, thereby facilitating research at the intersection of conventional CFD and machine learning.https://cassyni-user-files-prod.s3.amazonaws.com/D2eM9aV4KKXXgWQeDrswuY https://cassyni.com/events/6mn1dDjDiDdRdDe2ESfHGy/seminar/qa https://cassyni.com/events/6mn1dDjDiDdRdDe2ESfHGy/abstract https://cassyni-user-files-prod.s3.amazonaws.com/84AXUzZWBTbXdcAY289Gkv https://cassyni.com/events/6mn1dDjDiDdRdDe2ESfHGy?videoPreview=1 Reverse Engineering as a Curriculum Development Processnohttps://cassyni.com/events/6mn1dDjDiDdRdDe2ESfHGy?videoPreview=12025-08-07T16:00:00+00:003175.96Lived Places PublishingReverse engineering, as a curriculum development concept, offers an innovative approach to teaching fashion history by starting with current trends and deconstructing their influences. This method engages students by leveraging their familiarity with contemporary fashion to uncover historical, cultural, and technological contexts that shaped those designs. By analyzing modern garments, materials, and aesthetics, students trace the lineage of styles, techniques, and societal movements, fostering critical thinking and a deeper appreciation for the evolution of fashion. This practice-based pedagogy not only builds connections between the past and present but also encourages students to reflect on how fashion cycles, subcultures, and innovations influence contemporary identities and cultural narratives.https://cassyni-user-files-prod.s3.amazonaws.com/84AXUzZWBTbXdcAY289Gkv https://cassyni.com/events/EBW5KUS6J5wG7oAVCKX1gy/abstract https://cassyni-user-files-prod.s3.amazonaws.com/ER2EohSfBwrkVkjXGJR66S https://cassyni.com/events/BiG464CU6oAj5dvhjXiegm/seminar/qa https://cassyni.com/slides/outline/BiG464CU6oAj5dvhjXiegm https://cassyni.com/events/BiG464CU6oAj5dvhjXiegm/abstract https://cassyni-user-files-prod.s3.amazonaws.com/JiMLAZ8it7mYhiyrxGMsuY https://cassyni.com/events/BiG464CU6oAj5dvhjXiegm?videoPreview=1 Underwater invisibility: pushing pentamode cloaks into 3Dnohttps://cassyni.com/events/BiG464CU6oAj5dvhjXiegm?videoPreview=12025-04-22T13:00:00+00:003812.04MetaMATIn this talk, I will present the key developments of my PhD research on the design and implementation of 3D underwater acoustic cloaks using pentamode metamaterials (PMs). These engineered structures mimic the acoustic properties of fluids, exhibiting a high bulk modulus and nearly vanishing shear resistance. While PM-based cloaking has been successfully demonstrated in two dimensions, extending these concepts to realistic 3D applications poses significant challenges. The high bulk modulus of water, in particular, requires a fundamentally different microstructural kinematics. I will first present a novel 3D PM geometry that closely mimics the acoustic behaviour of water and serves as the basic building block for the cloak. The second part of the talk will focus on the critical challenge of wrapping a curved 3D surface—such as a sphere—with a cloak. Unlike 2D scenarios, there is no feasible conformal mapping in three dimensions, resulting in unavoidable geometric distortions. I will discuss our strategies to accommodate these deformations and their effect on the local material behaviour. Finally, I will describe the discretisation of the cloak into a lattice of unit cells and the complexities of wrapping a 3D object. Emphasis will be placed on maintaining lattice continuity and ensuring reliable inter-cell connectivity—key requirements for the transition from theory to experiment.https://cassyni-user-files-prod.s3.amazonaws.com/JiMLAZ8it7mYhiyrxGMsuY https://cassyni.com/events/Q4VnMmtUUbwK7nruzTDpTX/seminar/qa https://cassyni.com/slides/outline/Q4VnMmtUUbwK7nruzTDpTX https://cassyni.com/events/Q4VnMmtUUbwK7nruzTDpTX/abstract https://cassyni-user-files-prod.s3.amazonaws.com/M5GMPVCfd1NU93VNxtgzy4 https://cassyni.com/events/Q4VnMmtUUbwK7nruzTDpTX?videoPreview=1 Numerical Simulation of Circulation Control for Wing Section using Coanda Jetsnohttps://cassyni.com/events/Q4VnMmtUUbwK7nruzTDpTX?videoPreview=12025-06-24T14:00:00+00:002874.2AIAA JournalLarge-eddy simulations were carried out to describe the subsonic flow over a wing section, using Coanda-jet circulation control to augment lift. The computations correspond to an experimental investigation, where the section geometry consisted of a modified supercritical airfoil, with a jet that is blown over a one quarter circular cylindrical trailing-edge. Because the configuration does not include a slotted trailing-edge flap, the mechanical complexity and system weight may be reduced. As the experimental data consisted of only force measurements, computations were performed to augment the experiment and describe unsteady features of the flow. High-fidelity solutions were obtained to the unsteady three-dimensional Navier-Stokes equations, at a chord-based Reynolds of 475,000 and freestream Mach number of 0.1. Details of the numerical approach are outlined. For the baseline flow without control, several angles of attack were considered, and a grid-resolution study was carried out to assure numerical accuracy. Comparisons are made between the respective cases and with the available experimental data. In control cases, several different forms of control were considered. These consisted of: a) constant blowing across the entire span of the wing configuration, b) the use of a segmented-nozzle arrangement with an oscillating jet, and c) pulsed blowing of the Coanda jet. The use of a segmented nozzle and pulsed blowing were employed to reduce jet-mass flow requirements. Results of the various cases are compared and the effectiveness of control is quantified. Frequencies of flowfield unsteadiness is characterized, and physical features of the flowfields are elucidated. Videos are shown to illustrate unsteady features of the flowfields.https://cassyni-user-files-prod.s3.amazonaws.com/M5GMPVCfd1NU93VNxtgzy4 https://cassyni.com/events/EgBJUnbW8uR5wG9zzRdysB/abstract https://cassyni-user-files-prod.s3.amazonaws.com/M3fYVTnwMjnDFscABHMKTL https://cassyni.com/events/H8zyzm6qHnHzqGwFhU6krZ/seminar/qa https://cassyni.com/slides/outline/H8zyzm6qHnHzqGwFhU6krZ https://cassyni.com/events/H8zyzm6qHnHzqGwFhU6krZ/abstract https://cassyni-user-files-prod.s3.amazonaws.com/PStGDcunP6RCM9GmadY5g2 https://cassyni.com/events/H8zyzm6qHnHzqGwFhU6krZ?videoPreview=1 A computational homogenization methodology for the analysis and design of subwavelength mechanical and acoustic metamaterials on finite size domainsnohttps://cassyni.com/events/H8zyzm6qHnHzqGwFhU6krZ?videoPreview=12025-11-11T14:00:00+00:003736.6MetaMATThis talk will present the recent advancements in the computational homogenization techniques for modelling elastic and acoustic wave propagation in locally resonant metamaterials on finite size domain in both frequency and time domains, including transient regimes. I will start by describing the main idea of the transient computational homogenization approach that allows the direct simulations of wave propagation and attenuation on finite size domains. The general approach is suited for arbitrarily complex unit cell geometries and material behaviour, including material and geometrical non-linearities. As an example illustrating the emergent behaviour due to non-linearities, energy transfer by an auto-parametric resonance from propagative to evanescent wave will be shown. Next, extensions and applications of the approach will be presented for visco-elastic (lossy) metamaterials, porous materials including fluid-solid interaction and acoustic labyrinthine metamaterials. https://cassyni-user-files-prod.s3.amazonaws.com/PStGDcunP6RCM9GmadY5g2 https://cassyni.com/events/T1y4vS3L4wNKgnwHD2s7zV/seminar/qa https://cassyni.com/slides/outline/T1y4vS3L4wNKgnwHD2s7zV https://cassyni.com/events/T1y4vS3L4wNKgnwHD2s7zV/abstract https://cassyni-user-files-prod.s3.amazonaws.com/QW2ehnGEbrrRPbhzADgbvW https://cassyni.com/events/T1y4vS3L4wNKgnwHD2s7zV?videoPreview=1 Bridging the Physician-Community Gap Through Community Health Workers and the DULCE Modelnohttps://cassyni.com/events/T1y4vS3L4wNKgnwHD2s7zV?videoPreview=12026-01-08T21:00:00+00:003380.04Family MedicineObjectives: - Describe the role primary care physicians can have in state and community networking - Highlight the role of community health workers in perinatal and well baby care - Explore the benefits of the DULCE model (Developmental Understanding and Legal Collaboration for Everyone) in a FM residency clinic sitehttps://cassyni-user-files-prod.s3.amazonaws.com/QW2ehnGEbrrRPbhzADgbvW https://cassyni.com/events/5n65w3DmCFZ1Z2x7LUeyqf/seminar/qa https://cassyni.com/slides/outline/5n65w3DmCFZ1Z2x7LUeyqf https://cassyni.com/events/5n65w3DmCFZ1Z2x7LUeyqf/abstract https://cassyni-user-files-prod.s3.amazonaws.com/DgMCvPaoWB2o6S2osBMkGn https://cassyni.com/events/5n65w3DmCFZ1Z2x7LUeyqf?videoPreview=1 Introductory Remarksnohttps://cassyni.com/events/5n65w3DmCFZ1Z2x7LUeyqf?videoPreview=12025-06-20T07:30:00+00:00787.6Anti-Cancer Agents in Medicinal ChemistryNo abstracthttps://cassyni-user-files-prod.s3.amazonaws.com/DgMCvPaoWB2o6S2osBMkGn https://cassyni.com/events/CCWwXvdauCkhNreaCP3PSm/abstract https://cassyni-user-files-prod.s3.amazonaws.com/pFqS5wYSVAjSjq4Hjeeht https://cassyni.com/events/NaAFcujVXBJr3qe7W3viku/seminar/qa https://cassyni.com/slides/outline/NaAFcujVXBJr3qe7W3viku https://cassyni.com/events/NaAFcujVXBJr3qe7W3viku/abstract https://cassyni-user-files-prod.s3.amazonaws.com/KzjZTxyPZie2eWFerM21wU https://cassyni.com/events/NaAFcujVXBJr3qe7W3viku?videoPreview=1 Meshing and Mesh Adaptationnohttps://cassyni.com/events/NaAFcujVXBJr3qe7W3viku?videoPreview=12025-06-26T08:00:00+00:004784.84Nektar++ Development TeamOver the last year I have focused on slimming down the SpatialDomains Geometry classes to provide a suitable replacement for NekMesh's existing set of separate MeshElement classes. Benchmarking shows significant performance gains from this replacement, particularly in the input/output operations needed for upcoming mesh adaptation work.https://cassyni-user-files-prod.s3.amazonaws.com/KzjZTxyPZie2eWFerM21wU https://cassyni.com/events/RY5W1e8XZHZUxnSkFZCRcy/seminar/qa https://cassyni.com/slides/outline/RY5W1e8XZHZUxnSkFZCRcy https://cassyni.com/events/RY5W1e8XZHZUxnSkFZCRcy/abstract https://cassyni-user-files-prod.s3.amazonaws.com/G7umQsNPCEHd7D41iGAHNe https://cassyni.com/events/RY5W1e8XZHZUxnSkFZCRcy?videoPreview=1 Obstacles to Open Access publishing for researchers with weak institutional ties - epistemic injustice in academic publishingnohttps://cassyni.com/events/RY5W1e8XZHZUxnSkFZCRcy?videoPreview=12025-09-26T14:00:00+00:002916.4Library & Information ServicesIn October 2024, the TIB - Leibniz Information Centre for Science and Technology launched the IDAHO project, a groundbreaking effort to identify and describe barriers to open access publishing faced by researchers with weak institutional ties. In the frame of the IDAHO project, the term “weakly affiliated” encompasses a diverse group of researchers that may not have strong ties to academia but still engages in research and produces publications. The project adopts a comprehensive, multi-part exploratory methodology, combining both qualitative and quantitative methods to gain deeper insights into the research problem and focuses specifically on: independent researchers, citizens science, retired researchers, refugee scientists, researchers working for civil societies, industry enterprises, hospitals, non-profit and governmental organizations. In our presentation, we will share synthesized findings from ten qualitative interviews with targeted researchers, complemented by a global quantitative survey, uncovering the unique challenges researchers with weak institutional ties face in disseminating their research OA. We will also present the findings from qualitative interviews with journal editors, highlighting their awareness of identified obstacles, as well as the initiatives and strategies they employ to promote equality, inclusion, and the diversification of authors within their venues.https://cassyni-user-files-prod.s3.amazonaws.com/G7umQsNPCEHd7D41iGAHNe https://cassyni.com/slides/outline/pz7uTbDtfuQcZgR7t26Nq https://cassyni.com/events/pz7uTbDtfuQcZgR7t26Nq/abstract https://cassyni-user-files-prod.s3.amazonaws.com/WUAbeszqm43vPCELxrv5Tt https://cassyni.com/events/pz7uTbDtfuQcZgR7t26Nq?videoPreview=1 Protein Structure-Informed Bacteriophage Genome Annotation with Pholdnohttps://cassyni.com/events/pz7uTbDtfuQcZgR7t26Nq?videoPreview=12025-10-15T00:30:00+00:00364.44Microbiome Virtual International ForumBacteriophage (phage) genome annotation is essential for understanding their functional potential and suitability for use as therapeutic agents. Here we introduce Phold, an annotation framework utilising protein structural information that combines the ProstT5 protein language model and structural alignment tool Foldseek. Phold assigns annotations using a database of over 1.36 million predicted phage protein structures with high quality functional labels. Benchmarking reveals that Phold outperforms existing sequence-based homology approaches in functional annotation sensitivity whilst maintaining speed, consistency and scalability. Applying Phold to diverse cultured and metagenomic phage genomes shows it consistently annotates over 50% of genes on an average phage and 40% on an average archaeal virus. Comparisons of phage protein structures to other protein structures across the tree of life reveals that phage proteins commonly have structural homology to proteins shared across the tree of life, particularly those that have nucleic acid metabolism and enzymatic functions. Phold is available as free and open-source software at https://github.com/gbouras13/phold.https://cassyni-user-files-prod.s3.amazonaws.com/WUAbeszqm43vPCELxrv5Tt https://cassyni.com/events/4mjDVkM31dFFHhz6gDeDDo/seminar/qa https://cassyni.com/slides/outline/4mjDVkM31dFFHhz6gDeDDo https://cassyni.com/events/4mjDVkM31dFFHhz6gDeDDo/abstract https://cassyni-user-files-prod.s3.amazonaws.com/BcPN9EUdLYt2AbKeTVsu6W https://cassyni.com/events/4mjDVkM31dFFHhz6gDeDDo?videoPreview=1 Using visual research methods to explore the student experience - photovoice for research.nohttps://cassyni.com/events/4mjDVkM31dFFHhz6gDeDDo?videoPreview=12025-11-28T15:00:00+00:003409.04Library & Information ServicesWorking as an academic librarian I work with students from a range of backgrounds. I have used research to learn more about their experiences, so I can adapt my practice to suit their needs. In this seminar I will discuss how I have used photovoice as a research method to explore the experience of international students coming to study in the UK. Photovoice, also known as participatory photography, is a visual research method that encourages active participation in the project (Tewell, 2019; Hicks and Lloyd, 2018; Luo, 2017; Wang, 2003). I will provide an overview of photovoice and how it was used in the context of this project. In this project, the simplicity of the photographic prompts allowed the students to communicate their experiences in more depth. After summarising the research method used, the presentation will share the findings from my research, and I will reflect on how the project came together. The research project was funded by the AHRC-RLUK Professional Practice Fellowship Scheme for research and academic libraries. https://cassyni-user-files-prod.s3.amazonaws.com/BcPN9EUdLYt2AbKeTVsu6W https://cassyni.com/events/VxpeyErgoLR4wr2ZueF1Mw/abstract https://cassyni-user-files-prod.s3.amazonaws.com/5tfRB9bGCpX6o2hnywsBpa https://cassyni.com/events/VxpeyErgoLR4wr2ZueF1Mw?videoPreview=1 Pediatric Tech Talknohttps://cassyni.com/events/VxpeyErgoLR4wr2ZueF1Mw?videoPreview=12024-06-13T08:00:00+00:001874.44 School of Public PolicyAbstract not yet added.https://cassyni-user-files-prod.s3.amazonaws.com/5tfRB9bGCpX6o2hnywsBpa https://cassyni.com/events/R2LcWQPSQkt3YkKDuAY1do/seminar/qa https://cassyni.com/slides/outline/R2LcWQPSQkt3YkKDuAY1do https://cassyni.com/events/R2LcWQPSQkt3YkKDuAY1do/abstract https://cassyni-user-files-prod.s3.amazonaws.com/6gbXajohByEkZFSNNc8zR4 https://cassyni.com/events/R2LcWQPSQkt3YkKDuAY1do?videoPreview=1 Comprehensive scaling laws across animals, microorganisms and plantsnohttps://cassyni.com/events/R2LcWQPSQkt3YkKDuAY1do?videoPreview=12025-09-09T16:00:00+00:003336.96Royal Society PublishingScaling laws illuminate Nature’s biological principles and guide bioinspired materials and structural designs. In simple cases they are based on the principle that all laws of nature remain invariant under a change of units. A more general framework is a change of variables for the governing laws that takes all equations, boundary, and interaction conditions into themselves. We consider an accepted macroscale system of partial differential equations including coupled fluid dynamics, nonlinear elasticity, and rigid body mechanics for a complex organism. We show that there is a set of scaling laws where length, time, density, elastic modulus, viscosity, and gravitational constant undergo nontrivial scaling. We compare these results to extensive data sets mined from the literature on beating frequency of flying, swimming, and running animals, speed of bacteria, insects, fish, mammals and reptiles, leg stillness of mammals, and modulus of elasticity of plants. The uniform agreement of the scaling laws with the dynamics of fauna, flora, and microorganisms supports the dominating role of coupled nonlinear elasticity and fluid dynamics in evolutionary development. We conclude with predictions for some prehistoric cases for which observations are unavailable.https://cassyni-user-files-prod.s3.amazonaws.com/6gbXajohByEkZFSNNc8zR4 https://cassyni.com/events/RX1qfiYrFaMsNWtaf7GK3B/seminar/qa https://cassyni.com/slides/outline/RX1qfiYrFaMsNWtaf7GK3B https://cassyni.com/events/RX1qfiYrFaMsNWtaf7GK3B/abstract https://cassyni-user-files-prod.s3.amazonaws.com/J9XFeZRgMkewEZDCPJeW6J https://cassyni.com/events/RX1qfiYrFaMsNWtaf7GK3B?videoPreview=1 Thieme Cheminar: Boron in Organic Synthesisnohttps://cassyni.com/events/RX1qfiYrFaMsNWtaf7GK3B?videoPreview=12025-10-16T13:00:00+00:007450.48Thieme GroupJoin us for the Thieme Cheminar “Boron in Organic Synthesis” on Thursday, October 16, 2025, at 3:00 PM (CET) This special online event, brought to you by SynOpen Journal, highlights the versatile role of boron in organic synthesis and its importance in advancing organic chemistry. The program will feature outstanding talks from leading researchers in the field: 🔹Prof. Varinder Aggarwal (University of Bristol, UK) 🔹Prof. Andrei Yudin (University of Toronto, Canada) 🔹Prof. Benjamin J. Stokes (Santa Clara University, USA) The session will be chaired by Prof. Thierry Ollevier, Editor-in-Chief of SynOpen. Do not miss this unique opportunity to explore cutting-edge advances in boron chemistry and engage with some of the leading voices defining tomorrow’s organic chemistry!https://cassyni-user-files-prod.s3.amazonaws.com/J9XFeZRgMkewEZDCPJeW6J https://cassyni.com/slides/outline/J7KQ66Ms54yohdpjtuEkY5 https://cassyni.com/events/J7KQ66Ms54yohdpjtuEkY5/abstract https://cassyni-user-files-prod.s3.amazonaws.com/SxiGDsEmGFZzpGBnuv4JCv https://cassyni.com/events/J7KQ66Ms54yohdpjtuEkY5?videoPreview=1 An isoaspartate-induced impairment of OsHSFC1b transactivation negatively impacts seed vigour, seed weight and size in ricenohttps://cassyni.com/events/J7KQ66Ms54yohdpjtuEkY5?videoPreview=12025-08-07T08:30:00+00:00940.88NonePlants optimize seed size, weight, vigour, and various other features during seed development, which are important for successful propagation and establishment for human use. However, how plants achieve and maintain these seed traits is still elusive.  Our study reveals that the rice Heat Shock Transcription Factor OsHSFC1b is highly expressed in the embryo and during the later stage of seed development. Through overexpression and gene editing approach, we found that OsHSFC1b not only plays a significant role in preserving seed vigour and longevity by activating various genes participating in protection mechanisms but also regulates seed size and weight by modulating auxin biosynthesis, endosperm development, and seed filling. Furthermore, the function of OsHSFC1b is compromised due to isoaspartyl modification in seeds particularly during seed storage and upon aging. Our MS/MS analyses confirm isoaspartyl modification in the asparagine residues near the DNA-binding domain and nuclear localization sequence of OsHSFC1b, which adversely affects OsHSFC1b’s transactivation activity. However, PROTEIN L-ISOASPARTYL METHYLTRANSFERASE, interacts and repairs this isoaspartyl-mediated damage and facilitates the function of OsHSFC1b. Taken together, our study uncovers how isoaspartyl damage dampens the transactivation prowess of OsHSFC1b, yet the intervention of PIMT not only repairs but also elevates agronomically important seed traits.https://cassyni-user-files-prod.s3.amazonaws.com/SxiGDsEmGFZzpGBnuv4JCv https://cassyni.com/events/S1igwfE9VkmU1gLietDT8H/seminar/qa https://cassyni.com/slides/outline/S1igwfE9VkmU1gLietDT8H https://cassyni.com/events/S1igwfE9VkmU1gLietDT8H/abstract https://cassyni-user-files-prod.s3.amazonaws.com/N4tyBBUJsWds1ysz1LcVbL https://cassyni.com/events/S1igwfE9VkmU1gLietDT8H?videoPreview=1 From Pixels to Predictions: How Deep Learning Is Transforming Plankton Studiesnohttps://cassyni.com/events/S1igwfE9VkmU1gLietDT8H?videoPreview=12026-01-20T14:00:00+00:003566.36Springer Nature Sustainable Development Goals ProgrammePlankton are the foundation of marine ecosystems and critical regulators of the ocean’s carbon cycle, yet their small size and large variability make them difficult to study. This talk presents an integrated AI-driven framework for observing and predicting plankton dynamics. I will introduce PlanktonScope for high-resolution, in situ observation of plankton communities, and its accompanying image-processing pipeline, which applies deep-learning models for automated detection, classification, and enumeration. Building on these advances, I will highlight Plankton-Chronos, a time-series prediction model that uses long-term image datasets and large language models to forecast plankton abundance and community shifts. Together, these developments demonstrate how artificial intelligence can transform marine ecosystem monitoring, from capturing microscopic images to predicting large-scale ecological change.https://cassyni-user-files-prod.s3.amazonaws.com/N4tyBBUJsWds1ysz1LcVbL https://cassyni.com/slides/outline/TWx9LfsVLj397pB47DvHLh https://cassyni.com/events/TWx9LfsVLj397pB47DvHLh/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Sf5KyfenKeRYhFVjLM7zJr https://cassyni.com/events/TWx9LfsVLj397pB47DvHLh?videoPreview=1 Symposium on Economic Freedom: Reading the Swiss Constitutionnohttps://cassyni.com/events/TWx9LfsVLj397pB47DvHLh?videoPreview=12024-11-12T23:30:00+00:004053.0New Zealand Centre of International Economic LawJoin us for a public talk about how Swiss Federal Constitution openly recognises economic freedom as both a basic human right and a key principle of its market economy. Professor [**Nicolas Diebold**](https://www.unilu.ch/en/faculties/faculty-of-law/professorships/public-and-economic-law/staff/prof-dr-nicolas-diebold/#tab=c52495) from the University of Lucerne, a [visiting scholar](https://www.wgtn.ac.nz/law/centres/nzciel/latest-updates/nzciel-visiting-scholar-nicolas-diebold) with NZCIEL, will discuss the history, current impact, and future importance of this right in shaping Switzerland’s economic policies. The talk will also explore how government regulations and court decisions work together in one of the world’s strongest economies. The discussion and Q&A session will be chaired by Professor [**Susy Frankel**](https://people.wgtn.ac.nz/Susy.Frankel) FRSNZ, Chair in Intellectual Property and International Trade and an NZCIEL lead, and commented by [**Paul Scott**](https://people.wgtn.ac.nz/paul.scott), a senior lecturer at Te Herenga Waka and an NZCIEL research affiliate.https://cassyni-user-files-prod.s3.amazonaws.com/Sf5KyfenKeRYhFVjLM7zJr https://cassyni.com/slides/outline/2pXw2VXFPqMBxMtKb1LBf3 https://cassyni.com/events/2pXw2VXFPqMBxMtKb1LBf3/abstract https://cassyni-user-files-prod.s3.amazonaws.com/XALabsvPzJrSMZeJrVVm9Y https://cassyni.com/events/2pXw2VXFPqMBxMtKb1LBf3?videoPreview=1 Secular evolution of co-orbitalmotion of two exoplanets: semi-analytical investigation, Invariant manifolds near L1 and L2 in the Sun–Jupiter elliptic restricted three-body problemnohttps://cassyni.com/events/2pXw2VXFPqMBxMtKb1LBf3?videoPreview=12024-12-13T14:00:00+00:004324.72Celestial Mechanics and Dynamical AstronomyWe consider a system consisting of a star and two planets in co-orbital motion. Themasses of the planets are much smaller than the mass of the star. The problem is planar, the motion of all three bodies taking place in a fixed plane. Since the co-orbital motion corresponds to the 1:1 mean motion resonance, it can be studied by methods developed to investigate resonance effects. In this work, we employ one of the semi-analytical methods intended for studying resonance effects—an adiabatic approximation proposed by J. Wisdom. Evolutionary equations are constructed, which describe secular effects in the dynamics of the system. Using them, various scenarios for the behaviour of the system over long time intervals are analysed in detail. For clarity, diagrams are provided illustrating possible variants of secular evolution. In this paper, we present a way of combining the computation of invariant tori and their stable and unstable manifolds with the multiple shooting technique. We start by showing some of the results of Jorba (Nonlinearity 14(5):943–976, 2001) that should be modified in order to introduce the multiple shooting technique in these computations. After that, by a direct application in the planar elliptic restricted three-body problem (PERTBP), how to modify the equations and methods to compute the above-mentioned objects is introduced. In particular, the structure of the (systems of) equations and matrices involved in these computations is shown. An application of these computations can be found in Duarte and Jorba (Celest. Mech. Dyn. Astron 136:49, 2024), where the dynamics of comet 39P/Oterma is modelled as a PERTBP.https://cassyni-user-files-prod.s3.amazonaws.com/XALabsvPzJrSMZeJrVVm9Y https://cassyni.com/slides/outline/WyWzn5v3pHqYyCwExZ8QnR https://cassyni.com/events/WyWzn5v3pHqYyCwExZ8QnR/abstract https://cassyni-user-files-prod.s3.amazonaws.com/TYnmhB6tpmFvzmS4jqAWjY https://cassyni.com/events/WyWzn5v3pHqYyCwExZ8QnR?videoPreview=1 Disentangling the role of sucrose for stomatal movement regulationnohttps://cassyni.com/events/WyWzn5v3pHqYyCwExZ8QnR?videoPreview=12024-10-23T12:00:00+00:001082.08The New Phytologist FoundationThe role of sucrose for stomatal movement regulation has long been debated, with several controversial studies and theories. Here we demonstrated that sucrose concentration at the leaf apoplast underpin the diel course of tobacco stomatal conductance (gs), in which the daily stomatal opening and closure were associated with low and high concentration of apoplastic sucrose, respectively. In agreement with this, exogenously applied sucrose increased the speediness of both stomatal opening and closure in a concentration-dependent manner. We further showed that the light-induced stomatal opening is closely associated to the dynamic of sucrose and organic acids within guard cells. Interestingly, these sucrose-mediated stomatal responses were drastically reduced in plants with diminished capacity to import sucrose to their guard cells, highlighting that sucrose importation to these cells is important to modulate the magnitude of both stomatal opening and closure. Modelling analysis highlights that the metabolism of the apoplast rather than the leaf is the major determinant of the daily gs. Our results collectively indicate that sucrose is a master regulator of the daily gs, being capable of inducing and accelerating both stomatal opening and closure in a concentration and location of accumulation dependent manner.https://cassyni-user-files-prod.s3.amazonaws.com/TYnmhB6tpmFvzmS4jqAWjY https://cassyni.com/slides/outline/GA4sPaWJeZDvfGeXwuJgEh https://cassyni.com/events/GA4sPaWJeZDvfGeXwuJgEh/abstract https://cassyni-user-files-prod.s3.amazonaws.com/GUsjx5nbFWCnGMtTYZaKen https://cassyni.com/events/GA4sPaWJeZDvfGeXwuJgEh?videoPreview=1 BioModels Reproducibility Scorecardnohttps://cassyni.com/events/GA4sPaWJeZDvfGeXwuJgEh?videoPreview=12022-05-19T03:00:00+00:002881.72UKRNSystems biology modelling involves the mathematical representation of biological processes to study complex system behaviour and was expected to be least affected by the reproducibility crisis. However, models often fail to reproduce and the reasons for the failure and prevalence were not fully understood. In a recent study, we analyzed 455 kinetic models published in 152 peer-reviewed journals. Most of these models were manually encoded from scratch to assess the reproducibility. Our investigation revealed that 49% of the models could not be reproduced using the information provided in the manuscripts. Among the corresponding authors, we contacted over 70% did not respond. Models across several life science journals failed to reproduce, revealing a common problem in the peer-review process. As a solution, we proposed a simple easy-to-use reproducibility scorecard with 8 yes-or-no questions that can be used by model authors, reviewers and journal editors during the peer-review process. We demonstrated that the scorecard is a good indicator of model reproducibility. In this workshop we discuss about our study in details, run a hands-on training to use the scorecard to assess models during the peer-review process. The reproducibility crisis in systems biology modelling can be tackled as a community, where model authors, reviewers, journal editors and funding bodies embrace reproducibility more proactively than before.https://cassyni-user-files-prod.s3.amazonaws.com/GUsjx5nbFWCnGMtTYZaKen https://cassyni.com/slides/outline/BDapvk34FyguGAwBwRbgWZ https://cassyni.com/events/BDapvk34FyguGAwBwRbgWZ/abstract https://cassyni-user-files-prod.s3.amazonaws.com/YQPp2txHwG3pFzVtSHHeei https://cassyni.com/events/BDapvk34FyguGAwBwRbgWZ?videoPreview=1 Morphing and moving matter: mimicking naturenohttps://cassyni.com/events/BDapvk34FyguGAwBwRbgWZ?videoPreview=12025-02-14T10:00:00+00:003081.04UK Metamaterials NetworkNature's ingenuity serves as a profound source of inspiration for developing advanced materials and robotic systems. In this presentation, we explore how biological phenomena inform innovative engineering solutions, focusing on morphing structures and moving mechanisms, both grounded in our understanding of the underlaying mechanics principles. We highlight morphing structure designs inspired by the segmentation architectures found in biological organisms and the dehydration-induced corrugated folding observed in Rhapis excelsa leaves. These designs emphasize adaptability and efficient shape transformation, showcasing the potential for creating functional, morphable systems. Additionally, we examine moving mechanisms, featuring a snap-through enabled insect-scale jumping robot modeled after click beetles and a magnetic robot inspired by the coordinated movements of cilia. These systems prioritize effective modeling to achieve rapid, efficient motion and agile navigation in complex environments. By integrating principles from biology and mechanics, this presentation illustrates how natural strategies can lead to cutting-edge technological advancements, offering new perspectives on the design and modeling of intelligent systems.https://cassyni-user-files-prod.s3.amazonaws.com/YQPp2txHwG3pFzVtSHHeei https://cassyni.com/slides/outline/U1ezccYnauSjkydC6zsRRo https://cassyni.com/events/U1ezccYnauSjkydC6zsRRo/abstract https://cassyni-user-files-prod.s3.amazonaws.com/LErbfF4UcahZQy8bEJQq5p https://cassyni.com/events/U1ezccYnauSjkydC6zsRRo?videoPreview=1 Response and recovery: mycorrhizal fungi in disturbed environmentsnohttps://cassyni.com/events/U1ezccYnauSjkydC6zsRRo?videoPreview=12024-08-13T12:00:00+00:001091.92The New Phytologist FoundationSoils are dynamic systems that exist within an equilibrium influenced by their surroundings. Mycorrhizal fungi are sensitive to both above and belowground disturbances. These fungi are crucial for decomposition, nutrient cycling, and plant productivity, playing distinct roles in these landscapes. Limited methods for studying these fungi challenge our ability to understand their response to disturbance and their roles in ecosystem recovery. This talk will discuss trends in mycorrhizal fungal communities at various scales following disturbances, focusing on their implications for ecosystem restoration and their roles post-fire. By enhancing our understanding of how fungi respond to disturbances and the variables driving these responses, we can improve predictions of community assembly and structure across different environments. A fundamental understanding of the variation (or lack thereof) in fungal strategies, community composition, and their functions is essential to manage these fungi and their host plants across environments and disturbance regimes.https://cassyni-user-files-prod.s3.amazonaws.com/LErbfF4UcahZQy8bEJQq5p https://cassyni.com/slides/outline/7GRcfuNk9gBUczAupsx5YH https://cassyni.com/events/7GRcfuNk9gBUczAupsx5YH/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Y9HXNLwHGdsNCunoJw99re https://cassyni.com/events/7GRcfuNk9gBUczAupsx5YH?videoPreview=1 Application of CFD to Advance Thermal Management of Aerospace Systemsnohttps://cassyni.com/events/7GRcfuNk9gBUczAupsx5YH?videoPreview=12024-12-05T10:00:00+00:001931.04JKW Symposium TeamThough CFD has come a long way and widely used in industry, it is still “Colorful and Fancy Display” and “Constant Frustration and Disappointment” to many. Also, the following anonymous quote is still true: “No one believes the simulation except who did it! Everyone believes the test results except who did it!” If you do not believe this quote, just try to publish a paper that uses CFD to solve a science or engineering problem without experimental validation. Since experimental studies typically do not get the same scrutiny on verification and validation of their methods, this talk gives examples in heat transfer where CFD shows experimental studies could yield solutions that are wrong or provide incorrect guidance on design. Since AI is now vogue, where many researchers use machine learning tools to study engineering and science problems, some observations are made.https://cassyni-user-files-prod.s3.amazonaws.com/Y9HXNLwHGdsNCunoJw99re https://cassyni.com/events/JdN8rFmheZrEivcgPYE2U5/abstract https://cassyni-user-files-prod.s3.amazonaws.com/7yDMTVgTmScT8Mg3k22fd8 https://cassyni.com/events/K81jtwRE62QHih9ZyyWpjP/abstract https://cassyni-user-files-prod.s3.amazonaws.com/3eYKJWmcvgmYpVabNToL5U https://cassyni.com/events/VVdRsJ1FJe2iFCSi15TiQu/abstract https://cassyni-user-files-prod.s3.amazonaws.com/VD6LStW2e8QymNhS3r5R1G https://cassyni.com/events/S36CYWUaESA5DW99MR5kt5/seminar/qa https://cassyni.com/slides/outline/S36CYWUaESA5DW99MR5kt5 https://cassyni.com/events/S36CYWUaESA5DW99MR5kt5/abstract https://cassyni-user-files-prod.s3.amazonaws.com/9icLXdfxaaoRdPd1PnDSCn https://cassyni.com/events/S36CYWUaESA5DW99MR5kt5?videoPreview=1 *Mas*ter your obligations! Colonisation-induced grammatical change in Vanuatu’s indigenous languagesnohttps://cassyni.com/events/S36CYWUaESA5DW99MR5kt5?videoPreview=12025-04-23T01:10:00+00:002706.52Linguistics and Applied Language StudiesMany indigenous languages of Vanuatu have a grammatical marker *mas* to express positive deontic modality (necessity and obligation). *Mas* was borrowed from Bislama, an English-lexifier creole and Vanuatu's lingua franca; the source of Bislama's *mas* is ultimately English *must*. Most of these languages lack dedicated indigenous positive deontic modality morphemes. Instead, deontic force used to be organised around the explicit encoding of prohibitions/taboos. In this talk, I will discuss the reorganisation of the deontic modality systems of Vanuatu's languages, with a focus on the socioeconomic factors that likely drove it. I will start with a historical account of the contact between the people of Vanuatu and Western Europeans. More intense contact started around the 1850s and triggered a loss of over 90% of Vanuatu's population. This was due to Blackbirding (the often forceful indentured labour on plantations in Queensland), epidemics, and violence. This put local communities, with their egalitarian social structures, in a very disadvantageous position, as colonisers were establishing religious, educational, and government institutions, in which hierarchies and the communication of obligations became crucial. I will explore the impact that colonisation had on the language ecosystems in Vanuatu more broadly, to then focus on the factors that led to the grammatical change at hand. I will draw on primary and secondary linguistic data, the historical record, my own experiences during linguistic fieldwork in Vanuatu, language ecology theory, and linguistic theories of language contact and borrowing.https://cassyni-user-files-prod.s3.amazonaws.com/9icLXdfxaaoRdPd1PnDSCn https://cassyni.com/slides/outline/UWLDmviCRivZaSchu6zPc1 https://cassyni.com/events/UWLDmviCRivZaSchu6zPc1/abstract https://cassyni-user-files-prod.s3.amazonaws.com/62QjH9aqySDkmkz8EGswNe https://cassyni.com/events/UWLDmviCRivZaSchu6zPc1?videoPreview=1 The Long Arm of the Law (Charleston Conference)nohttps://cassyni.com/events/UWLDmviCRivZaSchu6zPc1?videoPreview=12024-11-14T15:00:00+00:003423.24Part of the nonprofit Annual Reviews organizationThe massive revolution in artificial intelligence has allowed users to produce text, imagery, and other content based solely on natural language prompts. In 2023, our session dealt with copyright issues raised on two sides of the AI question – AI’s input and AI’s output. These aspects have legal implications that are complex and newly evolving. The acceleration of AI developments has resulted in litigation, particularly regarding methods by which AI systems are “trained” to create literary, visual, and other artistic works: by exposing the programs to large amounts of data, which may consist of existing works such as text and images gathered from numerous sources. In the 2024 Long Arm session, we will hear from key participants "in the middle" between libraries, publishers, and authors. JSTOR is one of the world's leading content aggregators of journals, books, images, and other sources, occupying an information provision space between thousands of publishers and academic/public libraries. Nancy Kopans, Vice President, General Counsel, and Secretary of ITHAKA, will share the challenges that AI has introduced to all players in recent months and weeks (and days) and will describe the increasing complexities of JSTOR's aggregating role. The Copyright Clearance Center, underpinned by the principles of copyright, addresses both producer and customer demands for content and for ethical and workable licenses. Roy Kaufman, Managing Director of both Business Development and Government Relations for CCC, will address its worldwide brokering role in an increasingly dynamic environment, particularly with regard to "training." https://cassyni-user-files-prod.s3.amazonaws.com/62QjH9aqySDkmkz8EGswNe https://cassyni.com/slides/outline/4JZcWS1UvHnfQkrryKh6Bf https://cassyni.com/events/4JZcWS1UvHnfQkrryKh6Bf/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Q3735peeTndyLAkpGLSJoQ https://cassyni.com/events/4JZcWS1UvHnfQkrryKh6Bf?videoPreview=1 Balancing Quantity and Quality in Research Communicationnohttps://cassyni.com/events/4JZcWS1UvHnfQkrryKh6Bf?videoPreview=12025-01-14T14:00:00+00:003963.4Academic Publishing in EuropeThe panel discussion focused on the significant increase in research article output in recent years, driven by factors such as the COVID-19 pandemic, the rise of China as a research powerhouse, and the expansion of open access publishing. There is increasingly a tension between maintaining quality and rigor versus increasing quantity. The panel highlighted concerns about shifting incentives potentially undermining scientific integrity, while also noting that growth in open access journals is not limited to commercial publishers but includes society publishers as well. The discussion underscored the complex balance editors face between reducing article volume to improve impact factors and the financial pressures to increase output. https://cassyni-user-files-prod.s3.amazonaws.com/Q3735peeTndyLAkpGLSJoQ https://cassyni.com/events/ACadryJwp45RdZN6kGPR9F/seminar/qa https://cassyni.com/slides/outline/ACadryJwp45RdZN6kGPR9F https://cassyni.com/events/ACadryJwp45RdZN6kGPR9F/abstract https://cassyni-user-files-prod.s3.amazonaws.com/FBcMfVRp1R4pEHs9Bjbve https://cassyni.com/events/ACadryJwp45RdZN6kGPR9F?videoPreview=1 Programs, Origins and Immunomodulatory Functions of Myeloid Cells in Gliomanohttps://cassyni.com/events/ACadryJwp45RdZN6kGPR9F?videoPreview=12026-08-20T18:00:00+00:003798.04Center for Cancer TrainingGliomas are incurable malignancies notable for having an immunosuppressive microenvironment with abundant myeloid cells, the immunomodulatory phenotypes of which remain poorly defined1. Here we systematically investigate these phenotypes by integrating single-cell RNA sequencing, chromatin accessibility, spatial transcriptomics and glioma organoid explant systems. We discovered four immunomodulatory expression programs: microglial inflammatory and scavenger immunosuppressive programs, which are both unique to primary brain tumours, and systemic inflammatory and complement immunosuppressive programs, which are also expressed by non-brain tumours. The programs are not contingent on myeloid cell type, developmental origin or tumour mutational state, but instead are driven by microenvironmental cues, including tumour hypoxia, interleukin-1β, TGFβ and standard-of-care dexamethasone treatment. Their relative expression can predict immunotherapy response and overall survival. By associating the respective programs with mediating genomic elements, transcription factors and signalling pathways, we uncover strategies for manipulating myeloid-cell phenotypes. Our study provides a framework to understand immunomodulation by myeloid cells in glioma and a foundation for the development of more-effective immunotherapies.https://cassyni-user-files-prod.s3.amazonaws.com/FBcMfVRp1R4pEHs9Bjbve https://cassyni.com/events/M4sYze4NsVBdJJtXeNZYih/seminar/qa https://cassyni.com/slides/outline/M4sYze4NsVBdJJtXeNZYih https://cassyni.com/events/M4sYze4NsVBdJJtXeNZYih/abstract https://cassyni-user-files-prod.s3.amazonaws.com/FEhsySqTUgPr884CV5Pz6A https://cassyni.com/events/M4sYze4NsVBdJJtXeNZYih?videoPreview=1 Learning Structure-exploiting Reduced Models with Operator Inferencenohttps://cassyni.com/events/M4sYze4NsVBdJJtXeNZYih?videoPreview=12026-05-12T16:00:00+00:003772.84AIAA JournalIn silico experimentation is the way of the future: Computing enables engineering designers to explore new ideas beyond what is possible in physical experiments. But simulating complex physics is computationally expensive — just a single simulation can take days on a supercomputer, making it practically impossible for a designer to fully explore the high-dimensional space of design options. Reduced-order models address this challenge, giving a rapid simulation capability while retaining predictive power. Operator Inference is a non-intrusive reduced modeling approach that incorporates physical governing equations by defining a structured polynomial form for the reduced model and then learns the corresponding reduced operators from training data. Operator Inference retains the rigor and interpretability of projection-based model reduction, while achieving the portability and convenience of machine learning. I will discuss recent advances in embedding additional structure in Operator Inference models, including a nested formulation that exploits the inherent hierarchy within the reduced space and a block-structured formulation that reflects the structure of a multiphysics system. Incorporating this extra structure improves both the conditioning of the learning problem and the effectiveness of the learned reduced models. https://cassyni-user-files-prod.s3.amazonaws.com/FEhsySqTUgPr884CV5Pz6A https://cassyni.com/events/PY7aE4J14mx7fFN6C4UBSd/seminar/qa https://cassyni.com/slides/outline/PY7aE4J14mx7fFN6C4UBSd https://cassyni.com/events/PY7aE4J14mx7fFN6C4UBSd/abstract https://cassyni-user-files-prod.s3.amazonaws.com/B7N4KNwNdtgq4cMpjkFe7p https://cassyni.com/events/PY7aE4J14mx7fFN6C4UBSd?videoPreview=1 Bridging physical (MFA, LCA, IO) and dynamic (economic) models to capture consequential effects of circular economy policiesnohttps://cassyni.com/events/PY7aE4J14mx7fFN6C4UBSd?videoPreview=12026-02-18T16:00:00+00:004987.04Waste Management JournalCircular economy (CE) policies incur significant market effects by including price signals and other financial instruments to foster secondary material markets development. Physical models, such as material flow analyses (MFA), life cycle assessment/costing (LCA, LCC), extended input-output analyses all have limitations in capturing such consequences, because they neglect feedback effects due to changes in price and investments. Such changes occur when CE policies alter the market by mandating for example a certain quota of recycled material in product or by offering subsidies. While LCA or MFA fall short in capturing consequential effects, bridging physical and economic models is a promising avenue to enhance policy-making support. The seminar provides insights into i) recent research produced at the European Commission whereby in-house physical and global equilibrium models have been used for this purpose, and ii) perspectives for future research.https://cassyni-user-files-prod.s3.amazonaws.com/B7N4KNwNdtgq4cMpjkFe7p https://cassyni.com/events/WwqdvJzseeFx9ptZ9wKurd/seminar/qa https://cassyni.com/slides/outline/WwqdvJzseeFx9ptZ9wKurd https://cassyni.com/events/WwqdvJzseeFx9ptZ9wKurd/abstract https://cassyni-user-files-prod.s3.amazonaws.com/8QAWiAUqCK4MrQTiAcoqMQ https://cassyni.com/events/WwqdvJzseeFx9ptZ9wKurd?videoPreview=1 Special Issue Launch: 'Trauma and the Body: A Contemporary Perspective'nohttps://cassyni.com/events/WwqdvJzseeFx9ptZ9wKurd?videoPreview=12026-03-26T18:00:00+00:003481.64MultiPsych JournalThis seminar with Guest Editor Professor Divine Charura MBE introduces our new special issue at MultiPsych entitled 'Trauma and the Body: A Contemporary Persepctive'. We will hear about Professor Charura's research in this field, and interview him as newly appointed editorial board member for MultiPsych. This special issue encourages multidisciplinary contributions from psychologists, psychiatrists, psychotherapists and neuroscientists on the topic of trauma and the body and is open to all. We look forward to your submissions!https://cassyni-user-files-prod.s3.amazonaws.com/8QAWiAUqCK4MrQTiAcoqMQ https://cassyni.com/events/G8PWXob8UueKqtbr9HWBJu/seminar/qa https://cassyni.com/slides/outline/G8PWXob8UueKqtbr9HWBJu https://cassyni.com/events/G8PWXob8UueKqtbr9HWBJu/abstract https://cassyni-user-files-prod.s3.amazonaws.com/9fiTNhYmrUtHQHvVJhEjPL https://cassyni.com/events/G8PWXob8UueKqtbr9HWBJu?videoPreview=1 An interview with Editor-in-Chief Dr. Joseph Kvedar nohttps://cassyni.com/events/G8PWXob8UueKqtbr9HWBJu?videoPreview=12026-03-09T19:30:00+00:002250.04npj Digital Medicine In this inaugural episode of The Digital Pulse, the official podcast of npj Digital Medicine, we sit down with the journal’s Editor-in-Chief for an in-depth conversation exploring the evolving landscape of digital health, artificial intelligence, and the future of medicine. As digital technologies increasingly shape how healthcare is delivered, evaluated, and experienced, this discussion offers a rare behind-the-scenes perspective on how leading scientific journals are guiding innovation responsibly. The Editor-in-Chief, Dr. Joseph Kvedar, reflects on the journal’s mission, and listeners gain insight into emerging research priorities shaping the field today. Dr. Kvedar will share practical tips for getting your research published and discuss the different content formats available for authors looking to contribute to the journal. Whether you are an early-career researcher, clinician, or digital health innovator, this conversation offers valuable insight into navigating scientific publishing in the era of digital medicine.https://cassyni-user-files-prod.s3.amazonaws.com/9fiTNhYmrUtHQHvVJhEjPL https://cassyni.com/events/UyGqrCvfJAyHcMQWQMYFJu/abstract https://cassyni-user-files-prod.s3.amazonaws.com/G4fQoPBVYtvCLuxoHiCguL https://cassyni.com/events/UyGqrCvfJAyHcMQWQMYFJu?videoPreview=1 H3 – Automating Your Data Dictionarynohttps://cassyni.com/events/UyGqrCvfJAyHcMQWQMYFJu?videoPreview=12026-04-21T12:30:00+00:002499.64Research Analytics SummitHow to automate your Data Dictionary using Microsoft SQL Server’s built in functionality to add meta data describing columns and how to surface that information in Tableau. Will briefly show the equivalent functionality for adding meta data in MySQL and PostgreSQL.https://cassyni-user-files-prod.s3.amazonaws.com/G4fQoPBVYtvCLuxoHiCguL https://cassyni.com/slides/outline/Ff4AriAFyQdLQYx8r3RLyb https://cassyni.com/events/Ff4AriAFyQdLQYx8r3RLyb/abstract https://cassyni-user-files-prod.s3.amazonaws.com/L2tSDtinUHWf5FZ2pXiizA https://cassyni.com/events/Ff4AriAFyQdLQYx8r3RLyb?videoPreview=1 Using AI/LLMs for detecting scientific errorsnohttps://cassyni.com/events/Ff4AriAFyQdLQYx8r3RLyb?videoPreview=12025-06-17T16:00:00+00:005256.64For over a decade, forensic scientists/meta-scientists, publishers, and authors have developed and used software tools to find issues in scientific pre-prints and publications. The recent rise of Large Language Models (LLMs) provides these groups with a whole new range of tools. With this symposium, we will bring together people from four ongoing projects to discuss how the latest LLMs and other AI tools are being developed, evaluated, and used to detect errors in scientific publications: The Black Spatula Project, RegCheck, SocEnRep, and Psy-RAG. These projects involve people from different countries, and academic disciplines as well as people outside academia. The structures, pipelines, and goals of these projects differ. While the Black Spatula Project is an international grassroots initiative driven mostly by volunteer efforts, SocEnRep is a research and infrastructure project funded by the German Research Foundation (DFG), and RegCheck and Psy-RAG are also academic research projects based in Switzerland. The Black Spatula Project wants to make use of LLMs for detecting errors in scientific publications, SocEnRep develops a pipeline for automated reproducibility checks in economics and the social sciences, RegCheck compares preregistration documents to papers, and Psy-RAG combines LLMs and RAG to identify problematic patterns, inconsistencies, and error propagation in psychological research. What all of these projects have in common is that they use AI/LLMs for scalable and (semi-)automated checks of academic publications. We will first present preliminary results, the challenges ahead and potential solutions, with a moderated discussion at the end.https://cassyni-user-files-prod.s3.amazonaws.com/L2tSDtinUHWf5FZ2pXiizA https://cassyni.com/events/XSWs5dAHVTjmyHt4x3St2q/seminar/qa https://cassyni.com/slides/outline/XSWs5dAHVTjmyHt4x3St2q https://cassyni.com/events/XSWs5dAHVTjmyHt4x3St2q/abstract https://cassyni-user-files-prod.s3.amazonaws.com/MN6XEGzwbxThewFMhtneAi https://cassyni.com/events/XSWs5dAHVTjmyHt4x3St2q?videoPreview=1 Active and Topological Mechanical Metamaterialsnohttps://cassyni.com/events/XSWs5dAHVTjmyHt4x3St2q?videoPreview=12026-04-21T13:00:00+00:002594.52MetaMATTopological insulators enable robust, unidirectional edge modes resistant to defects. Inspired by this, we present a topologically protected mechanical metamaterial exhibiting spin-like bifurcation-driven nonreciprocity for one-way elastic siliton-wave propagation. By leveraging angular momentum bias in a resonator lattice—analogous to magnetic bias in photonics—we break time-reversal symmetry, creating a mechanical analogue of magnetically biased graphene. Additionally, we explore topology-nonlinearity interplay using bistable networks with asymmetric energy landscapes, inducing nonlinear transition waves that act as mechanical diodes. Numerical simulations and experiments confirm the robustness and tunability of these states, enabling precise soliton-wave control. Our work advances phononic metamaterials for vibration isolation, energy harvesting, and nonreciprocal waveguiding. In addition, we will discuss how active solicitation can drastically change the landscape of mechanical metamaterials. https://cassyni-user-files-prod.s3.amazonaws.com/MN6XEGzwbxThewFMhtneAi https://cassyni.com/events/6k6emSp3Ya3poqbLRprnMB/abstract https://cassyni-user-files-prod.s3.amazonaws.com/L7SZAUBo18FTKc3QdkwAm4 https://cassyni.com/events/HdgDA5GF8bmpejvmVaDj2m/seminar/qa https://cassyni.com/slides/outline/HdgDA5GF8bmpejvmVaDj2m https://cassyni.com/events/HdgDA5GF8bmpejvmVaDj2m/abstract https://cassyni-user-files-prod.s3.amazonaws.com/N6YdWTDwt7LewVvdX49V9p https://cassyni.com/events/HdgDA5GF8bmpejvmVaDj2m?videoPreview=1 Unsteady Simulation of Laminar Separation Bubble over Low-Reynolds-number Airfoil (KSAS EFD-CFD Workshop Case 5) using PyFRnohttps://cassyni.com/events/HdgDA5GF8bmpejvmVaDj2m?videoPreview=12025-07-10T12:00:00+00:003212.84PyFRImplicit Large Eddy Simulations are conducted about flow separation characteristics over low-Reynolds-number Airfoil, proposed in the Korean Society for Aeronautical and Space Sciences Experimental and Computational Fluid Dynamics (KSAS EFD-CFD) comparison workshop. In the low-Reynolds-number flow, the laminar separation bubbles (LSB) can occur on the suction region of the airfoil, also depending on the angle of attack, may fail to recover pressure and reattach. In this study, non-linear aerodynamics arising from separation are simulated using high accurate scale-resolving solver PyFR. A parametric study was conducted to assess the effects of solution polynomial order, grid resolution, spanwise domain extent, and computational precision. An optimal simulation conditions was confirmed that a fourth-order accurate simulation, a spanwise length of 0.5 times the chord, and single-precision computation provided an effective balance between accuracy and computational efficiency. A comparison between result obtained in the optimal conditions and the experimental data from the Mars Wind Tunnel at Tohoku University indicates that the simulations predicted the non-linear lift characteristics and stall behavior that were subsequently observed in the experiments. Additionally, the influence of wind tunnel wall interference is investigated by introducing a virtual sidewall model. The presence of sidewall-induced disturbances is shown to reduce the size of the LSB near the wall, thereby mitigating the non-linear lift response.https://cassyni-user-files-prod.s3.amazonaws.com/N6YdWTDwt7LewVvdX49V9p https://cassyni.com/events/F99YfhKrQiPY7eeCnF8HCh/seminar/qa https://cassyni.com/slides/outline/F99YfhKrQiPY7eeCnF8HCh https://cassyni.com/events/F99YfhKrQiPY7eeCnF8HCh/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Y7ZWqejw2q3SvHRoHXoweN https://cassyni.com/events/F99YfhKrQiPY7eeCnF8HCh?videoPreview=1 New Articulations of the Theory of Oppositionsnohttps://cassyni.com/events/F99YfhKrQiPY7eeCnF8HCh?videoPreview=12026-04-29T14:00:00+00:006575.04Logica UniversalisPresentation of the SUL book "New Articulations of the Theory of Oppositions", 7th World Congress on the Square of Opposition - Leuven, Belgium, 2022. Then there will be a general discussion about the square project (past, present, future) and presentation of questions addresses in the book. https://cassyni-user-files-prod.s3.amazonaws.com/Y7ZWqejw2q3SvHRoHXoweN https://cassyni.com/slides/outline/2pE5mZrVxsACLoe4UvPzV3 https://cassyni.com/events/2pE5mZrVxsACLoe4UvPzV3/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Jff5FatX7TAGwV7V57Rvj8 https://cassyni.com/events/2pE5mZrVxsACLoe4UvPzV3?videoPreview=1 NANOSPRESSO: toward personalized locally produced nucleic acid nanomedicinesnohttps://cassyni.com/events/2pE5mZrVxsACLoe4UvPzV3?videoPreview=12025-07-09T14:00:00+00:005463.72Frontiers in Science#### A new frontier in rare disease treatment A new point-of-care model for affordable, on-demand production of personalized nucleic acid nanomedicines could revolutionize how hospitals treat rare diseases. The NANOSPRESSO platform, published in a [*Frontiers in Science* lead article](https://www.frontiersin.org/journals/science/articles/10.3389/fsci.2025.1458636/full), could enable hospital pharmacists to rapidly create inexpensive, personalized therapeutic cartridges—akin to espresso capsules—for rare disease patients at their bedside. Join the article authors for an in-depth discussion on how NANOSPRESSO could boost access to personalized nucleic acid therapies, even in low-resource settings, and overcome regulatory challenges. Hear our expert panel explore how NANOSPRESSO could open up treatments for underfunded and underserved rare conditions worldwide—which affect 36 million patients in the EU alone. [Click here to register.](https://events.frontiersin.org/nanospresso-personalized-medicine/Cassyni)https://cassyni-user-files-prod.s3.amazonaws.com/Jff5FatX7TAGwV7V57Rvj8 https://cassyni.com/events/P3aTdti2Em6vaUSRndekeh/abstract https://cassyni-user-files-prod.s3.amazonaws.com/LAtJ3es73t5ziwZD3WAr2A https://cassyni.com/events/8E8LFPJH52VJGY9imyq26y/seminar/qa https://cassyni.com/slides/outline/8E8LFPJH52VJGY9imyq26y https://cassyni.com/events/8E8LFPJH52VJGY9imyq26y/abstract https://cassyni-user-files-prod.s3.amazonaws.com/H8WzuZVXT65oPZQxyv3juG https://cassyni.com/events/8E8LFPJH52VJGY9imyq26y?videoPreview=1 Meet the Editorsnohttps://cassyni.com/events/8E8LFPJH52VJGY9imyq26y?videoPreview=12026-09-10T17:00:00+00:003749.92MultiPsych JournalWe warmly welcome you to this live informal community event where you can learn more about our new gold open access journal MultiPsych, hear about our aims and vision, and ask any questions you may have about the journal. All are welcome! Join me Dr Charlie O'Brien, Editor-in-Chief for Psychology at Wiley and editor of the journal. We also warmly welcome our Commissioning Editor Professor Divine Charura MBE who will share more about our current commissioning, open call for papers, and current special issues. If you are new to publishing your work, interested in peer reviewing for the journal, or have any burning questions that you would like to ask the MultiPsych team, grab a beverage of your choice and come and join us!https://cassyni-user-files-prod.s3.amazonaws.com/H8WzuZVXT65oPZQxyv3juG https://cassyni.com/events/CfxmfY8129UYjBuWgdbbFT/seminar/qa https://cassyni.com/slides/outline/CfxmfY8129UYjBuWgdbbFT https://cassyni.com/events/CfxmfY8129UYjBuWgdbbFT/abstract https://cassyni-user-files-prod.s3.amazonaws.com/7C8xmj8WprzhrxEo7s6yAE https://cassyni.com/events/CfxmfY8129UYjBuWgdbbFT?videoPreview=1 Navigating regulatory complexities: Challenges and shifting problem framings in turning microplastics into a European policy objectnohttps://cassyni.com/events/CfxmfY8129UYjBuWgdbbFT?videoPreview=12026-09-17T15:00:00+00:002390.76Cambridge PrismsMicroplastics are widely discussed as a pervasive environmental issue, yet decisive action and turning them into a governable “policy object” has proven to be slow and challenging. This paper investigates the shifting and heterogeneous problem framings of microplastic pollution and the regulatory complexities that emerge from them. Drawing on research from science and technology studies, we analyze how microplastics remained “hidden in plain sight” for decades, obscured by limited scientific standardization, competing problematizations, debates over scientific evidence, widespread cultural imaginaries and economic interests. The research reveals that the path from scientific knowledge to policy action is not linear but a process of co-production, where public concern, scientific capabilities and political agendas continuously reshape one another. We trace the evolution of the issue – from marine pollution to other media, human health and now nanoplastics – highlighting how each shift opens up new questions posing new (regulatory) challenges. The findings demonstrate that effective environmental governance requires more than data; it demands a critical understanding of the complex innovation pathways that produce such residues. We conclude that durable solutions require extended infrastructures of responsibility and care and the development of adaptive institutional frameworks capable of navigating scientific uncertainty and contested values.https://cassyni-user-files-prod.s3.amazonaws.com/7C8xmj8WprzhrxEo7s6yAE https://cassyni.com/events/J79fQKGYeuRSpmeLBVc6kM/seminar/qa https://cassyni.com/slides/outline/J79fQKGYeuRSpmeLBVc6kM https://cassyni.com/events/J79fQKGYeuRSpmeLBVc6kM/abstract https://cassyni-user-files-prod.s3.amazonaws.com/RJJkziV43gqsx3AkK5DKin https://cassyni.com/events/J79fQKGYeuRSpmeLBVc6kM?videoPreview=1 The influence of wall roughness on moderately dense, gas-particle flow in a vertical pipe.nohttps://cassyni.com/events/J79fQKGYeuRSpmeLBVc6kM?videoPreview=12026-09-15T13:00:00+00:004612.56Granular MatterWe show that the nature of the boundaries has a strong influence on the particle and gas profiles in a steady, fully developed flow of spherical particles and a turbulent gas through a vertical, circular pipe. The boundaries considered are featureless-frictional and bumpy-frictionless. Bumpy-frictionless boundaries increase the particle velocity fluctuations and the particle pressure over those of featureless walls and are likely to stabilize the flow against the development of clusters. https://cassyni-user-files-prod.s3.amazonaws.com/RJJkziV43gqsx3AkK5DKin https://cassyni.com/slides/outline/LaPgdjWArCBwBi7tjBWjUH https://cassyni.com/events/LaPgdjWArCBwBi7tjBWjUH/abstract https://cassyni-user-files-prod.s3.amazonaws.com/KsuHivKiQ5qrsdzLZEBF18 https://cassyni.com/slides/outline/7EtNPH2zzqEWYJC5QwT7zm https://cassyni.com/events/7EtNPH2zzqEWYJC5QwT7zm/abstract https://cassyni-user-files-prod.s3.amazonaws.com/UWiYEF5N5DRtdryik3gkUW https://cassyni.com/slides/outline/S1zv5xP1XN2jU9itYizYDK https://cassyni.com/events/S1zv5xP1XN2jU9itYizYDK/abstract https://cassyni-user-files-prod.s3.amazonaws.com/8oh9jffkzKcD7cczUwqCer https://cassyni.com/events/S1zv5xP1XN2jU9itYizYDK?videoPreview=1 Cells, bureaucracy and corruptionnohttps://cassyni.com/events/S1zv5xP1XN2jU9itYizYDK?videoPreview=12026-09-23T17:00:00+00:003336.76Bulletin of Mathematical BiologyWe often look at bureaucracies, such as our own universities, and think of them as overgrown and inefficient. But arguably the most elaborate bureaucracy in the known universe lies within each of us, whether student, professor or paper-pushing Vice President. This bureaucracy is the cell. The vast majority of genes and proteins within cells are effectively bureaucrats, regulating each other rather than building things. Regulation requires communication through an intricate network of intracellular signaling, which in turn extends beyond the cells as the chatter among cells that regulates tissues. I compare mathematical models of how populations and rules are regulated, examine how bureaucracy provides robustness to self-organized systems, and investigate the vulnerability of these complex systems to being corrupted. In particular, we have come to see cancer as corruption of the system of signaling that maintains tissue integrity in the face of uncertainty and disturbance, and reflect that back to society to think about how corruption, a violation of public trust, can be modeled. https://cassyni-user-files-prod.s3.amazonaws.com/8oh9jffkzKcD7cczUwqCer https://cassyni.com/events/F9jd4v9TsHqoBgGdnAqZTj/abstract https://cassyni-user-files-prod.s3.amazonaws.com/3aZddZKzbYQacdwXR9U646 https://cassyni.com/slides/outline/DgVNnc63cwLfs5U66TdgRs https://cassyni.com/events/DgVNnc63cwLfs5U66TdgRs/abstract https://cassyni-user-files-prod.s3.amazonaws.com/VM12ebDteMua3ZnmgdZkR4 https://cassyni.com/events/DgVNnc63cwLfs5U66TdgRs?videoPreview=1 Beyond the Blockchain: Crypto Fundamentals Demystifiednohttps://cassyni.com/events/DgVNnc63cwLfs5U66TdgRs?videoPreview=12023-05-09T23:00:00+00:002997.08Business SchoolThis abstract explores fundamental cryptocurrency concepts, differentiating them from traditional money and digital currencies. Value is presented as a shared human construct, with fiat currency defined as legal tender whose value derives from state trustworthiness but is subject to centralized control and inflation. Cryptocurrencies are characterized as digital currencies verified by decentralized, cryptographic systems, ensuring censorship resistance, immutability, irreversible transactions, and often a limited supply, exemplified by Bitcoin's 21 million coin cap. Bitcoin, the original and largest cryptocurrency, operates on a public, peer-to-peer ledger, demonstrating high efficiency for large transactions, such as a $260,000 donation costing $0.06 and completing in three seconds. The analysis differentiates Central Bank Digital Currencies (CBDCs)—digital fiat currencies retaining centralized control—from Altcoins. A key distinction is drawn between coins, which are native blockchain assets (e.g., Ether), and tokens, built upon existing blockchains (e.g., ERC-20 tokens, non-fungible tokens). Cryptocurrency exchanges are categorized into Centralized Exchanges (CEXs) and Decentralized Exchanges (DEXs). CEXs, like Binance, involve a middleman, offering convenience and support but requiring Know Your Customer (KYC) verification and carrying custodial risks. DEXs facilitate peer-to-peer, non-custodial trading via smart contracts, providing privacy and user control but demanding technical expertise without customer support. This foundational overview is essential for understanding the evolving crypto landscape.https://cassyni-user-files-prod.s3.amazonaws.com/VM12ebDteMua3ZnmgdZkR4 https://cassyni.com/events/M6F4bVJocAaEW8gxLuRrUV/abstract https://cassyni-user-files-prod.s3.amazonaws.com/49thLb5qkoqqDsGw5eGmZ8 https://cassyni.com/slides/outline/PZV5puYRoTLis5AWtbLVCR https://cassyni.com/events/PZV5puYRoTLis5AWtbLVCR/abstract https://cassyni-user-files-prod.s3.amazonaws.com/EAGXrBk2RcZTB2Z8USg16v https://cassyni.com/events/PZV5puYRoTLis5AWtbLVCR?videoPreview=1 Toward a universal model-based framework for wave control in extremely tunable meta-systemsnohttps://cassyni.com/events/PZV5puYRoTLis5AWtbLVCR?videoPreview=12025-06-16T07:00:00+00:001825.68ETOPIMOptimizing a reconfigurable wave system (e.g., reconfigurable intelligent surface, dynamic metasurface antenna, physical neural network) for a desired functionality is generally challenging because the effects of the tunable degrees of freedom are intertwined. In fact, the stronger the coupling between the tunable entities is, the more control reconfigurable wave systems offer over their transfer function [1], [2]. In this talk, I will discuss our recent efforts to formulate and calibrate physics-based models of reconfigurable wave systems. I will present closed-form and gradient-descentbased methods to calibrate the parameters of such models so that they can serve as digital twins for a priori unknown experimental reconfigurable wave systems, including a calibration method compatible with intensity-only detection [3], [4], [5]. I will carefully explore the role of ambiguities in these physics-based digital twins, clarifying in what scenarios ambiguities need to be lifted and how that can be achieved [4], [5], [6]. By comparison with physics-agnostic digital twins, I will highlight the favorable inductive bias of physics-based models [3]. Once calibrated, these physics-based digital twins enable efficient in-software optimization of the reconfigurable wave system’s configuration for a desired functionality without further access to the experimental system. I will share insights into efficient optimization algorithms, notably for systems with few-bit programmable degrees of freedom. https://cassyni-user-files-prod.s3.amazonaws.com/EAGXrBk2RcZTB2Z8USg16v https://cassyni.com/slides/outline/WUZYUUbmws6WMtA6G2uRM7 https://cassyni.com/events/WUZYUUbmws6WMtA6G2uRM7/abstract https://cassyni-user-files-prod.s3.amazonaws.com/3nNqbqEHnz2CguXtWGGxpN https://cassyni.com/events/WUZYUUbmws6WMtA6G2uRM7?videoPreview=1 Topology protects edge currents in stochastic and biological systemsnohttps://cassyni.com/events/WUZYUUbmws6WMtA6G2uRM7?videoPreview=12025-06-18T03:00:00+00:001850.72ETOPIMHow the cell functions and which dynamics it chooses to go into, remain mysterious. We lack a clear understanding of the underlying mechanisms that give rise to outcomes given specific conditions such as the underlying genes or kinetic rates. Here, we use topological winding numbers to predict phase transitions between multistability and oscillations in a simple gene switch, providing simple analytical expressions for properties of the steadystate. More broadly, I will discuss fundamental diAerences with quantum topology, namely the need for non-reciprocity. Lastly, I provide examples in other biological and synthetic systems, showing how topology sheds light on emergent phenomena in non-equilibrium stochastic systems.https://cassyni-user-files-prod.s3.amazonaws.com/3nNqbqEHnz2CguXtWGGxpN https://cassyni.com/slides/outline/WyD9XAFJPKeZMegyrUCDcR https://cassyni.com/events/WyD9XAFJPKeZMegyrUCDcR/abstract https://cassyni-user-files-prod.s3.amazonaws.com/GWupbzsqXsaBKou82TxxnS https://cassyni.com/events/WyD9XAFJPKeZMegyrUCDcR?videoPreview=1 Active metamaterials: From non-reciprocal nonlinear dynamics to adaptive locomotionnohttps://cassyni.com/events/WyD9XAFJPKeZMegyrUCDcR?videoPreview=12025-06-19T23:00:00+00:001861.16ETOPIMThis study explores active metamaterials—engineered solids that incorporate energy injection via non-reciprocal interactions—to achieve autonomous locomotion and adaptive shape dynamics without centralized control. Using mechatronic unit cells that break Newton’s third law through non-pairwise forces, the materials exhibit asymmetric elastic responses characterized by an odd elasticity tensor, enabling phenomena such as spontaneous rolling, crawling, and transitions between locomotion modes. Experiments on floating robotic lattices demonstrate that these active solids generate limit cycles driven by a curl in the force field, resulting in self-sustained oscillations and robust motion that conserves momentum internally rather than relying on external momentum exchange. The materials show resilience to partial motor failure and adapt their locomotion in response to environmental constraints, embodying a form of embodied intelligence akin to brainless biological organisms like sea stars. Theoretical analysis and homogenization link microscopic activity to macroscopic odd elasticity, revealing an active percolation transition governing the propagation of non-reciprocal forces. Impact tests reveal asymmetric bouncing and non-Hermitian skin effects in wave propagation, highlighting novel nonlinear wave physics. Additionally, machine learning approaches confirm that non-reciprocity optimally facilitates locomotion, even when non-local interactions are permitted. The research opens pathways toward designing autonomous, adaptive robotic materials capable of complex, environment-responsive behaviors and suggests future directions involving more intricate cyclic and non-cyclic actuation sequences, with implications for soft robotics, biofilm cleaning, and nonlinear physics of active matter.https://cassyni-user-files-prod.s3.amazonaws.com/GWupbzsqXsaBKou82TxxnS https://cassyni.com/slides/outline/6GnwCyu4SRxcCCQFLFc7vm https://cassyni.com/events/6GnwCyu4SRxcCCQFLFc7vm/abstract https://cassyni-user-files-prod.s3.amazonaws.com/DzoyLE3bx5XjVDyo9kNzva https://cassyni.com/events/6GnwCyu4SRxcCCQFLFc7vm?videoPreview=1 Stem cell regulators of root behaviournohttps://cassyni.com/events/6GnwCyu4SRxcCCQFLFc7vm?videoPreview=12025-07-08T12:00:00+00:002030.04NoneThe activity of meristems in central to the growth and development of plants. They are the sites of cell division, and are maintained through the control of the identity and activity of stem cells within the meristems. These stem cells are undifferentiated but divide to generate surrounding differentiated tissues. We are interested in the molecular mechanisms that regulate stem cell identity and activity, with a particular focus on the root apical meristem of the model plant Arabidopsis. Root development is a critical feature of plant adaptation to environments, anchoring plants in the soil, acting as a mediator of soil stresses, and interaction with microorganisms. I will discuss our recent progress in identifying new molecular regulators of meristem function, and show how the mathematical modelling of gene-signalling networks can help us understand the complexities of the regulatory process. https://cassyni-user-files-prod.s3.amazonaws.com/DzoyLE3bx5XjVDyo9kNzva https://cassyni.com/slides/outline/8k2xSQ8gdij6Z8soswWkeh https://cassyni.com/events/8k2xSQ8gdij6Z8soswWkeh/abstract https://cassyni-user-files-prod.s3.amazonaws.com/3dJmpPX8LucAsiHtKeuUiS https://cassyni.com/events/8k2xSQ8gdij6Z8soswWkeh?videoPreview=1 Soil microbes influence the ecology and evolution of plant plasticitynohttps://cassyni.com/events/8k2xSQ8gdij6Z8soswWkeh?videoPreview=12025-07-10T12:00:00+00:00880.64NoneStress often induces plant trait plasticity, and microbial communities also alter plant traits. Therefore, it is unclear how much plasticity results from direct plant responses to stress vs indirect responses due to stress-induced changes in soil microbial communities. To test how microbes and microbial community responses to stress affect the ecology and potentially the evolution of plant plasticity, I grew plants in four stress environments (salt, herbicide, herbivory, and no stress) with microbes that had responded to these same environments or with sterile inoculant. Plants delayed flowering under stress only when inoculated with live microbial communities, and this plasticity was maladaptive. However, microbial communities responded to stress in ways that accelerated flowering across all environments. Microbes also affected the expression of genetic variation for plant flowering time and specific leaf area, as well as genetic variation for plasticity of both traits, and disrupted a positive genetic correlation for plasticity in response to herbicide and herbivory stress, suggesting that microbes may affect the pace of plant evolution. Together, these results highlight an important role for soil microbes in plant plastic responses to stress and suggest that microbes may alter the evolution of plant plasticity. https://cassyni-user-files-prod.s3.amazonaws.com/3dJmpPX8LucAsiHtKeuUiS https://cassyni.com/slides/outline/EBCE4YmLs7kGWEvE6EapWy https://cassyni.com/events/EBCE4YmLs7kGWEvE6EapWy/abstract https://cassyni-user-files-prod.s3.amazonaws.com/AmjMc5LhEx9C8VNTbWhgX8 https://cassyni.com/events/EBCE4YmLs7kGWEvE6EapWy?videoPreview=1 Forging new institutions and alliancesnohttps://cassyni.com/events/EBCE4YmLs7kGWEvE6EapWy?videoPreview=12025-07-02T08:00:00+00:005542.6The seminar addresses the critical need for forging new institutions and alliances to advance metascience and the broader scientific ecosystem. It highlights the formation of the Metascience Alliance, a global coalition aiming to unify diverse stakeholders across disciplines, sectors, and geographies to accelerate scientific progress by fostering collaboration, workforce development, and cross-sector matchmaking. The discussion underscores the limitations of traditional research institutions in addressing complex, mid-scale scientific challenges and introduces Focused Research Organizations (FROs) as innovative entities designed to tackle foundational gaps by pursuing specific, quantifiable technical milestones with dedicated full-time teams and open data practices. Examples include organizations advancing neural connectomics, biological data accessibility, and drug-target screening. The seminar also presents perspectives from the African Open Science community, emphasizing efforts to promote open research practices, infrastructure development, and capacity building through regional networks and training programs despite funding constraints. Additionally, insights from a major publishing entity illustrate the value of cross-sector collaboration and data-driven approaches to research evaluation, gender equity, and public trust. Institutional design is critically examined, revealing the conservatism of public sector structures and advocating for a paradigm shift toward intelligence-centered, flexible, and innovative organizational models inspired by digital and biological systems. The collective discourse calls for radical redesign of research institutions and funding frameworks to embed metascience centrally, thereby enabling transformative scientific and societal outcomes.https://cassyni-user-files-prod.s3.amazonaws.com/AmjMc5LhEx9C8VNTbWhgX8 https://cassyni.com/slides/outline/DAkVHNLxUQfET3LZk4yGSh https://cassyni.com/events/DAkVHNLxUQfET3LZk4yGSh/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Jf1pfexyxNJtPmk7MZNVbt https://cassyni.com/events/DAkVHNLxUQfET3LZk4yGSh?videoPreview=1 Integrating Distributed Resources into the U.S. Power Systemnohttps://cassyni.com/events/DAkVHNLxUQfET3LZk4yGSh?videoPreview=12017-11-03T09:00:00+00:003703.96 School of Public PolicyThe integration of distributed energy resources (DERs) into the U.S. power system presents both opportunities and challenges critical to addressing climate change and energy security. This analysis situates DERs—including distributed solar, combined heat and power, demand response, and electric vehicles—within the broader context of decarbonizing electricity generation and enhancing grid resilience. Key insights derive from modeling efforts using the National Energy Modeling System (NEMS) adapted at Georgia Tech, which evaluate the cost-effectiveness and regional equity implications of carbon pricing policies combined with energy efficiency programs. Findings indicate that energy efficiency remains one of the least-cost and most impactful mitigation strategies, capable of reducing demand growth and competing favorably against new generation capacity. The study highlights the evolving temporal and spatial dynamics of peak electricity demand, especially under high renewable penetration, where solar generation shifts peak loads to evening hours, necessitating complementary resources and grid services. The role of intermediaries and aggregators in managing DERs and enabling new market mechanisms, such as negative demand response and vehicle-to-grid services, is emphasized as essential for optimizing system benefits. Policy simulations reveal that carbon tax revenues recycled on a per-emission basis can mitigate regional disparities, enhancing equity while incentivizing emissions reductions. The analysis underscores the importance of integrating engineering, economics, and social science to design policies that accelerate the clean energy transition, create jobs, and improve public health. Future directions include refining market structures to value DER services accurately and expanding financial mechanisms to broaden energy efficiency adoption.https://cassyni-user-files-prod.s3.amazonaws.com/Jf1pfexyxNJtPmk7MZNVbt https://cassyni.com/slides/outline/P3kCKfoLevfHT32zYCg5DF https://cassyni.com/events/P3kCKfoLevfHT32zYCg5DF/abstract https://cassyni-user-files-prod.s3.amazonaws.com/DWUUchcoS2VcJNqLUd29in https://cassyni.com/events/P3kCKfoLevfHT32zYCg5DF?videoPreview=1 Digital Sovereignty and the Open Internet: Can they Coexist?nohttps://cassyni.com/events/P3kCKfoLevfHT32zYCg5DF?videoPreview=12025-04-04T08:00:00+00:003840.72 School of Public PolicyThe evolving global political and economic order has intensified debates on digital sovereignty and its compatibility with the foundational values of the Open Internet. Digital sovereignty broadly refers to the desire of states or other actors to exercise control over online activities within their territorial or jurisdictional reach, often manifesting as efforts to regulate foreign companies or assert jurisdictional authority. Diverse interpretations exist: in China and Russia, digital sovereignty has taken the form of sovereign digital spaces or firewalls, while in Europe, the concept has developed into a multifaceted notion encompassing self-determination not only of states but also of individuals and communities. European discourse frames digital sovereignty as a normative project aimed at shaping a digital transformation grounded in democratic values, human rights, and rule-based governance, contrasting with both authoritarian digital models and market-driven U.S. digital capitalism. However, concerns arise regarding Europe’s externalization of these ambitions, potentially imposing normative frameworks on other regions. Beyond state-centric views, digital sovereignty also encompasses corporate power, with large technology firms exercising quasi-sovereign control over digital infrastructure and data, raising questions about surveillance capitalism and data colonialism. Postcolonial perspectives emphasize indigenous data rights and critique the extraction of data from Global South populations. The analysis highlights that digital sovereignty is a contested and pluralistic concept, with implications for governance models, individual rights, and global digital order. Its coexistence with the Open Internet depends on how openness and sovereignty are defined and balanced amid competing political, economic, and normative interests.https://cassyni-user-files-prod.s3.amazonaws.com/DWUUchcoS2VcJNqLUd29in https://cassyni.com/slides/outline/YS4gCf6JzdBZJnW8TL9e5s https://cassyni.com/events/YS4gCf6JzdBZJnW8TL9e5s/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Av9vU11xLTNGxrK5t8bDBC https://cassyni.com/events/YS4gCf6JzdBZJnW8TL9e5s?videoPreview=1 Panel Discussion: The Self-Governing Internetnohttps://cassyni.com/events/YS4gCf6JzdBZJnW8TL9e5s?videoPreview=12016-11-02T09:00:00+00:004782.04 School of Public PolicyThe panel discussion addresses the historic transition of the Internet Assigned Numbers Authority (IANA) functions from U.S. government oversight to a global multi-stakeholder governance model, completed in 2016 after nearly two decades of planning. This transition represents a novel institutional experiment in global Internet governance, characterized by decentralized, consensus-driven decision-making involving diverse stakeholders—including governments, private sector entities, civil society, and technical communities—without direct governmental control. Key issues examined include the role and autonomy of ICANN’s staff and board, mechanisms to ensure accountability and prevent capture by dominant interests, and the balance between technical standard-setting bodies (such as the IETF and IAB) and policy-making functions within ICANN. The discussion highlights the importance of robust accountability frameworks, including the empowered community’s ability to hold ICANN’s leadership to account, and the ongoing nature of governance reforms. The voluntary and interoperable nature of the Internet’s architecture underpins the governance model’s legitimacy and resilience, distinguishing it from treaty-based international regimes. Challenges such as potential mission creep, influence by state actors within multi-stakeholder processes, and the need for broad participation to prevent capture are acknowledged. The transition’s technical impact on the stability, security, and resiliency of the Domain Name System (DNS) is assessed as neutral or positive, with rigorous testing confirming no increased risk. The panel concludes that while the transition marks a significant milestone, Internet governance remains an evolving process requiring continuous collaboration, consensus-building, and vigilance to maintain an open, secure, and trusted global Internet.https://cassyni-user-files-prod.s3.amazonaws.com/Av9vU11xLTNGxrK5t8bDBC https://cassyni.com/events/TVadjpd4c3eXugnnSrSeMj/seminar/qa https://cassyni.com/slides/outline/TVadjpd4c3eXugnnSrSeMj https://cassyni.com/events/TVadjpd4c3eXugnnSrSeMj/abstract https://cassyni-user-files-prod.s3.amazonaws.com/QwQzw9NfefdxUwKxwhwAqC https://cassyni.com/events/TVadjpd4c3eXugnnSrSeMj?videoPreview=1 The price and value of water: An economic reviewnohttps://cassyni.com/events/TVadjpd4c3eXugnnSrSeMj?videoPreview=12025-10-15T08:00:00+00:001769.88Cambridge PrismsThe presentation will review common misunderstandings around the price, costs and values of water. https://cassyni-user-files-prod.s3.amazonaws.com/QwQzw9NfefdxUwKxwhwAqC https://cassyni.com/slides/outline/Cg8WMKDKSK2ubkW5SCcup1 https://cassyni.com/events/Cg8WMKDKSK2ubkW5SCcup1/abstract https://cassyni-user-files-prod.s3.amazonaws.com/23buzwf8foUie6m7Riyusk https://cassyni.com/events/Cg8WMKDKSK2ubkW5SCcup1?videoPreview=1 Biophysics in Africa: Assessment of the effect of heavy metals on the tissue mechanics of african prawnsnohttps://cassyni.com/events/Cg8WMKDKSK2ubkW5SCcup1?videoPreview=12025-06-26T06:00:00+00:001258.2Springer Nature Physics CommunityIncreased pollution of air and aquatic environment by natural and anthropogenic activities has led to biosorption of heavy metals by aquatic plants and animals in the habitats. The absorbed heavy metals pose a health hazard to both aquatic inhabitants such as Penaeus indicus and their consumers. Contamination due to heavy metal consumption by such aquatic plants and animals were presumed to affect their tissuelar qualities which are consumed as food. Recent studies on concentrations of Mn, Cu, Zn, Pb and Cd in whole prawn specimens and water samples from Epe Lagoon, Lagos State, using Techcomp AA 6000 atomic absorption spectrophotometer yielded concentrations of the order of Mn; 69.36 ± 78.53mg/kg > Zn; 52.88 ± 4.01mg/kg > Cu; 54.82 ± 13.88mg/kg > Pb; 9.18 ± 7.18mg/kg > Cd; 0.83 ± 0.20mg/kg with the mean concentrations of Mn, Cu and Pb in prawn specimens being above the maximum limits recommended by World Health Organisation. This study therefore considered the effect of heavy metals on tissue mechanics of African prawns, P. indicus at Mnarani Old Ferry location in Indian Ocean, Kenya. Ten litres of water and 0.5kg soil sediments samples were obtained from six sites of Indian Ocean along the Mnarani Old ferry mixed and sediment ground for homogeneity, analyzed using the XRF for presence of heavy metals, then used in aquaculture for the test experiment. The control experiment was done using water and soil sediments from heavy metal free sites. The presence of Iron (Fe), thallium (Tl), lead (Pb) and nickel (Ni) was established in the homogeneous water and soil sediment samples. Tissues from mature P. indicus from the test aquarium and control were ethically extracted and tested for heavy metals showing presence of Fe, Tl, Pb and Nickel in the tissues from test aquarium. The mechanical properties of P. indicus tissues were determined and compared experimentally in the laboratory. The Young’s modulus for tensile properties for tissues with heavy metals was 256.72 kPa exceeding the measurement for tissues without heavy metals by 69.45 kPa. Tissues with heavy metals were found to be hard, stiff and with high strength when compared to tissues without heavy metals. The hardness, stiffness and strength for tissues with heavy metals were 2.70 kPa/mm2, 68.03 N/m, and 112.62 kPa exceeding the respective measurements for tissues without heavy metals by 1.40 kPa/mm2, 12.63 N/m, and 33.12 kPa. It has been reported that heavy metals bond with tissue proteins altering their structure thus tissues become strong, stiff, hard and with higher young modulus due to heavy metals contamination. This study therefore informs environmentalists, health sector specialists, food scientists and standards controls about effect of heavy metal poisoning on the African prawns, P. indicus which compromises on their quality as food.https://cassyni-user-files-prod.s3.amazonaws.com/23buzwf8foUie6m7Riyusk https://cassyni.com/events/L5tCACS5RYGUF7JneV2R5o/seminar/qa https://cassyni.com/slides/outline/L5tCACS5RYGUF7JneV2R5o https://cassyni.com/events/L5tCACS5RYGUF7JneV2R5o/abstract https://cassyni-user-files-prod.s3.amazonaws.com/DauvSQ7wcg9Z7XCbRQrxpe https://cassyni.com/events/L5tCACS5RYGUF7JneV2R5o?videoPreview=1 Wearable ultrasound technologynohttps://cassyni.com/events/L5tCACS5RYGUF7JneV2R5o?videoPreview=12026-04-15T16:00:00+00:003560.08UK Microsystems NetworkThe use of wearable electronic devices that can acquire vital signs from the human body noninvasively and continuously is a significant trend for healthcare. The combination of materials design and advanced microfabrication techniques enables the integration of various components and devices onto a wearable platform, resulting in functional systems with minimal limitations on the human body. Physiological signals from deep tissues are particularly valuable as they have a stronger and faster correlation with the internal events within the body compared to signals obtained from the surface of the skin. In this presentation, I will demonstrate a soft ultrasonic technology that can noninvasively and continuously acquire dynamic information about deep tissues and central organs. I will also showcase examples of this technology's use in recording blood pressure and flow waveforms in central vessels, monitoring cardiac chamber activities, and measuring core body temperatures. The soft ultrasonic technology presented represents a platform with vast potential for applications in consumer electronics, defense medicine, and clinical practices.https://cassyni-user-files-prod.s3.amazonaws.com/DauvSQ7wcg9Z7XCbRQrxpe https://cassyni.com/slides/outline/WTVt8Z26e9ttmcbvfayJmK https://cassyni.com/events/WTVt8Z26e9ttmcbvfayJmK/abstract https://cassyni-user-files-prod.s3.amazonaws.com/MZ25MHQThEkcNaNpV6K9xi https://cassyni.com/events/WTVt8Z26e9ttmcbvfayJmK?videoPreview=1 Generative AI-Driven Structural and Safety Design across Multiple-Domain Engineeringnohttps://cassyni.com/events/WTVt8Z26e9ttmcbvfayJmK?videoPreview=12025-09-15T07:15:00+00:003355.96ArtIStE - Artificial Intelligence in Structural EngineeringGenerative AI-driven structural and safety design is a crucial element of smart construction. Traditional human-centric methods are often inefficient and overly dependent on individual expertise, frequently falling short of engineering requirements. Targeting the intelligent design demand of multiple-domain engineering (e.g., buildings, MEPs, and infrastructures), this study presents a high-quality, efficient design method driven by generative AI. Based on generative AI models such as diffusion models, generative adversarial networks, and graph neural networks, an intelligent design algorithm is proposed based on "data-knowledge-mechanics" fusion learning. This method effectively addresses the challenges of limited training data and quality inconsistency while ensuring compliance, safety, and cost-efficiency. Case studies involving building structural design, fire sprinkler design, and rock-filled dam design demonstrate that AI-generated design outcomes achieve expert-level quality, meeting design code requirements with significantly improved efficiency (approximately 10 times faster than traditional workflows). This research advances intelligent construction by creating a self-evolving framework integrating domain knowledge with data-driven learning.https://cassyni-user-files-prod.s3.amazonaws.com/MZ25MHQThEkcNaNpV6K9xi https://cassyni.com/slides/outline/6FjGs4KP8ikzbvr5jog1Ly https://cassyni.com/events/6FjGs4KP8ikzbvr5jog1Ly/abstract https://cassyni-user-files-prod.s3.amazonaws.com/7dWwgNSJQB22XkS1yApvN2 https://cassyni.com/events/6FjGs4KP8ikzbvr5jog1Ly?videoPreview=1 The cultural lives of birdsnohttps://cassyni.com/events/6FjGs4KP8ikzbvr5jog1Ly?videoPreview=12022-02-17T06:00:00+00:002984.92Part of the nonprofit Annual Reviews organizationAn explosion of research is finding that culture — once thought to be exclusive to humans — is widespread among animals and plays an important part in their social lives and survival. Birds offer some of the most interesting and surprising examples of animal culture. Just as with human languages, songbirds have dialects that are learned and passed down through generations. Construction and use of tools by crows and problem solving by cockatoos also appear to be culturally learned and transmitted. Learn what researchers mean by bird culture, what’s known about how it develops and is sustained, and what it means for how we think about and relate to birds and other animals.https://cassyni-user-files-prod.s3.amazonaws.com/7dWwgNSJQB22XkS1yApvN2 https://cassyni.com/slides/outline/KFEQDr8k9DyCq8jjKy1cq https://cassyni.com/events/KFEQDr8k9DyCq8jjKy1cq/abstract https://cassyni-user-files-prod.s3.amazonaws.com/XVJyLMEEKzkMWCg2tF8hQr https://cassyni.com/events/KFEQDr8k9DyCq8jjKy1cq?videoPreview=1 The global quasigeostrophic approximation in shallow waternohttps://cassyni.com/events/KFEQDr8k9DyCq8jjKy1cq?videoPreview=12025-02-19T06:00:00+00:001707.4Leeds Institute for Fluid DynamicsIt is often said that the quasigeostrophic approximation does far better than it should, meaning that it can often be usefully applied in situations where the conditions assumed in its derivation are poorly satisfied. We will consider how far this statement can be pushed by comparing the full and the approximate dynamics in a simple but geophysically relevant flow in which two of the usual conditions underlying the approximation, small Rossby number and limited latitudinal extent, are clearly violated. The comparison was developed while teaching the quasigeostrophic approximation in the Geophysical Fluid Dynamics course at the University of St Andrews.https://cassyni-user-files-prod.s3.amazonaws.com/XVJyLMEEKzkMWCg2tF8hQr https://cassyni.com/slides/outline/3nVFde5kwRzTZmcJH1seLm https://cassyni.com/events/3nVFde5kwRzTZmcJH1seLm/abstract https://cassyni-user-files-prod.s3.amazonaws.com/6gGBvxkwvbXvYY1yPHkMQa https://cassyni.com/events/3nVFde5kwRzTZmcJH1seLm?videoPreview=1 Substrate Wettability Affects Mixing During Droplet Coalescencenohttps://cassyni.com/events/3nVFde5kwRzTZmcJH1seLm?videoPreview=12020-11-23T06:00:00+00:00574.4Leeds Institute for Fluid DynamicsInternal jets can vastly improve mixing efficiency during droplet coalescence. For free droplets, jet formation depends on geometry, initial configuration and fluid properties. When at least one of the coalescing droplets is on a substrate, we systematically demonstrate that the three-phase contact line and substrate wettability are crucial too. In particular, using both high-speed imaging and quantitatively validated numerical simulations incorporating the Kistler dynamic contact angle model (with hysteresis) we investigate internal jet formation during the coalescence of an initially static free droplet and a sessile droplet of the same fluid. We identify and elucidate a mechanism of jet formation arising for surprisingly low sessile to free droplet volume ratios, showing that the presence of a substrate can improve mixing efficiency. Moreover, this mechanism is found to depend on substrate wettability with the importance of advancing contact angle subordinated to that of receding contact angle. Droplet geometry and fluid properties are also considered to thoroughly explain the dynamics observed.https://cassyni-user-files-prod.s3.amazonaws.com/6gGBvxkwvbXvYY1yPHkMQa https://cassyni.com/slides/outline/G8hMnjFsusqKTSr7FNSNUu https://cassyni.com/events/G8hMnjFsusqKTSr7FNSNUu/abstract https://cassyni-user-files-prod.s3.amazonaws.com/AxZDDunCV3hjytN7afaW78 https://cassyni.com/events/G8hMnjFsusqKTSr7FNSNUu?videoPreview=1 AI's Development and Governance -- Perspective from Chinanohttps://cassyni.com/events/G8hMnjFsusqKTSr7FNSNUu?videoPreview=12025-09-26T01:00:00+00:001993.04Risk Sciences[***Risk Sciences***](https://www.keaipublishing.com/en/journals/risk-sciences/) aims to foster diverse, multidisciplinary insights in risk sciences, bridging theory and practice through a series of academic activities. Professor Liang's research interests primarily lie in science, technology and innovation policy, globalization of R&D, intellectual property rights and standardization, and the governance of emerging technologies and innovation. This speech record is an excerpt from Professor Liang's keynote speech for the [Risk Sciences Colloquium – Artificial Intelligence and Risk Management](https://www.keaipublishing.com/en/journals/risk-sciences/event/risk-sciences-colloquium-artificial-intelligence-and-risk-management/) , which was held on September, 26, 2025, in Beijing, China.https://cassyni-user-files-prod.s3.amazonaws.com/AxZDDunCV3hjytN7afaW78 https://cassyni.com/slides/outline/AhZiHD975qkF4abseTSaVT https://cassyni.com/events/AhZiHD975qkF4abseTSaVT/abstract https://cassyni-user-files-prod.s3.amazonaws.com/NuoVEAS9uFGsyHwNtKZbxa https://cassyni.com/events/AhZiHD975qkF4abseTSaVT?videoPreview=1 Learning to Design Lightweight Structures: Accelerating Form-Finding through Machine Learning and Differentiable Programmingnohttps://cassyni.com/events/AhZiHD975qkF4abseTSaVT?videoPreview=12025-09-17T07:00:00+00:003268.52ArtIStE - Artificial Intelligence in Structural EngineeringThrough evolutionary refinement, natural forms such as seashells have achieved exceptionally high stiffness-to-weight ratios. At the meso and architectural scale, designing such lightweight forms poses significant computational challenges. Their nonlinear mechanical behavior governs their optimal form, necessitating advanced design methods which are computationally expensive. In this talk, we present novel numerical methods that apply machine learning and differentiable programming to accurately accelerate the design of such forms across multiple scales. We showcase the practical value of our methods for the design of beam networks, masonry vaults, and gridhells; and validate our numerical results with physical experiments and demonstrators. Our work bridges the gap between computational mechanics and artificial intelligence, facilitating the design of mechanically efficient forms, bringing us closer to the material economy and elegance exemplified in natural forms.https://cassyni-user-files-prod.s3.amazonaws.com/NuoVEAS9uFGsyHwNtKZbxa https://cassyni.com/slides/outline/XSpiLYq2vRvmar8L48P5Cq https://cassyni.com/events/XSpiLYq2vRvmar8L48P5Cq/abstract https://cassyni-user-files-prod.s3.amazonaws.com/EyYQ2DZ7B8KzuTJX9Bx8VL https://cassyni.com/events/XSpiLYq2vRvmar8L48P5Cq?videoPreview=1 Welcome & Opening Remarksnohttps://cassyni.com/events/XSpiLYq2vRvmar8L48P5Cq?videoPreview=12026-01-13T08:45:00+00:00324.36Academic Publishing in EuropeNo abstracthttps://cassyni-user-files-prod.s3.amazonaws.com/EyYQ2DZ7B8KzuTJX9Bx8VL https://cassyni.com/slides/outline/6kQW2NUnyYEpRPqbXunyXB https://cassyni.com/events/6kQW2NUnyYEpRPqbXunyXB/abstract https://cassyni-user-files-prod.s3.amazonaws.com/M1WuLUiJMiFamDqksVTPb4 https://cassyni.com/events/6kQW2NUnyYEpRPqbXunyXB?videoPreview=1 Sustainability-Linked Debt, Capital Structure, and Endogenous Defaultnohttps://cassyni.com/events/6kQW2NUnyYEpRPqbXunyXB?videoPreview=12025-07-06T01:00:00+00:001211.96Risk SciencesWithin a dynamic structural credit model augmented with carbon taxes and subsidies, we study perpetual debt financing when firms issue sustainability‑linked bonds (SLBs). Unlike conventional bonds, SLBs trigger penalty coupons if agreed sustainability targets are missed. We show that SLBs induce firms to choose a lower endogenous default boundary and extend the firm’s expected lifetime. The resulting stability can allow firms to carry more debt efficiently, so the optimal capital structure can deliver a lower weighted‑average cost of capital (WACC) and raise firm value. Our findings demonstrate that SLBs can align environmental objectives with improved long‑term financial performance. This speech record is an excerpt from Professor Chen's keynote speech for the [Risk Sciences Colloquium – 2025 International Workshop on Risk Sharing (IWRS)](https://www.keaipublishing.com/en/journals/risk-sciences/event/2025-international-workshop-on-risk-sharing-iwrs/) , which was held on July 6-7, 2025, in Beijing, China. This video is categorized under ***Climate Change and Sustainability***.https://cassyni-user-files-prod.s3.amazonaws.com/M1WuLUiJMiFamDqksVTPb4 https://cassyni.com/events/EA8ZidBfZQYeuyN4VnehwB/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Cba9TJvB4mEvWU6uG4iRpa https://cassyni.com/slides/outline/Q38Gkve3jvYhuy4VHvMWhj https://cassyni.com/events/Q38Gkve3jvYhuy4VHvMWhj/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Qkx8vL6pJgBha46iF8gu6e https://cassyni.com/events/Q38Gkve3jvYhuy4VHvMWhj?videoPreview=1 Metasurfaces for Wireless Communications - Towards Machine Learning in the Wave Domainnohttps://cassyni.com/events/Q38Gkve3jvYhuy4VHvMWhj?videoPreview=12026-01-21T15:00:00+00:003641.12UK Metamaterials NetworkIn this talk, we introduce wave-domain processing enabled by reconfigurable metasurfaces with the aim to redesign the physical layer of wireless communications. We will discuss the motivations, enabling technologies and our recent contributions in this emerging field of research.https://cassyni-user-files-prod.s3.amazonaws.com/Qkx8vL6pJgBha46iF8gu6e https://cassyni.com/events/JbzdFQXGutTdX6pFh1MiiH/abstract https://cassyni-user-files-prod.s3.amazonaws.com/6dDZSbyuaHQUTi6UuSFW1C https://cassyni.com/slides/outline/K6eEJ6AoMM1gWsM9HSeWyb https://cassyni.com/events/K6eEJ6AoMM1gWsM9HSeWyb/abstract https://cassyni-user-files-prod.s3.amazonaws.com/YUyR115Vf2oh3mNd1L5Z8z https://cassyni.com/events/K6eEJ6AoMM1gWsM9HSeWyb?videoPreview=1 AI Governance: Navigating Risk, Regulation, and Responsibilitynohttps://cassyni.com/events/K6eEJ6AoMM1gWsM9HSeWyb?videoPreview=12025-06-25T01:00:00+00:006148.24Risk SciencesThis seminar series is jointly organized by [***World Salon***](https://www.world-salon.com/) and [***Risk Science***](https://www.keaipublishing.com/en/journals/risk-sciences/). Professor Runhuan Feng is a Chair Professor in the School of Economics and Management at Tsinghua University. He is a Fellow of the Society of Actuaries and a Chartered Enterprise Risk Analyst. Prior to joining Tsinghua, he was a tenured Professor, the State Farm Companies Foundation Endowed Professor at the University of Illinois at Urbana-Champaign, the Faculty Lead for the Finance and Insurance sector at the Discovery Partnership Institute of the University of Illinois System. He is currently serving as the Executive Editor-in-Chief for Risk Sciences. Professor Volker H. Schmidt's current research, conceptualized within the framework of "Global Modernity", focuses on global social change and its practical as well as normative implications. His latest work, a book reconstructing the semantic evolution of the concept of society and entitled "From Societas to World Society. Genealogy of a Concept", appeared in May 2025. Robert D. Atkinson. As founder and president of the Information Technology and Innovation Foundation (ITIF), recognized as the world’s top think tank for science and technology policy, Robert D. Atkinson leads a prolific team of policy analysts and fellows that is successfully shaping the debate and setting the agenda on a host of critical issues at the intersection of technological innovation and public policy. Professor Zheng LIANG now serves as the professor of the School of Public Policy and Management, Tsinghua University, as well as the research fellow and deputy director of China Institute for Science &Technology Policy at Tsinghua University (CISTP), which is jointly established by Ministry of Science and Technology of China and Tsinghua University, mainly focusing on the studies of S&T policy and the national strategy of S&T development.https://cassyni-user-files-prod.s3.amazonaws.com/YUyR115Vf2oh3mNd1L5Z8z https://cassyni.com/events/Cfpf6PYa1LquzVqfHxJ3sB/seminar/qa https://cassyni.com/slides/outline/Cfpf6PYa1LquzVqfHxJ3sB https://cassyni.com/events/Cfpf6PYa1LquzVqfHxJ3sB/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Ped53tbwBXwdvkH9WTTZnW https://cassyni.com/events/Cfpf6PYa1LquzVqfHxJ3sB?videoPreview=1 Why Double-double?nohttps://cassyni.com/events/Cfpf6PYa1LquzVqfHxJ3sB?videoPreview=12026-03-03T12:00:00+00:004875.32Department of AeronauticsDouble-double is a much simpler and more powerful laminate than the traditional Quad laminate based on 0, ±45, 90 plies. DD is a [±Theta/±Psi]r that can be homogenized by having repeat index r equal to 4 or higher. A homogenized laminate is like an orthotropic metal. It is easier to analyze and optimize, and can have one, not thousands of stacking sequences. Homogenized laminates can be tapered to save weight and cost. Ply drops can be in singles and placed on the exterior surfaces. The interior of laminates is free of discontinuities, and wrinkles. Having only 4-ply building blocks, thin plies are perfect match with DD. Pre-plied DD prepreg tape with thin plies can simplify layup along one-axis without cross-plying. The rate of deposition can be 6X, and tapering by ply drops is simple. With thin plies, failure modes in delamination, micro-cracking and splitting can be suppressed. Coordinate transformation can be described by invariants. Trace, the sum of the diagonal composites of the stiffness matrix, will be the single parameter for laminate stiffness. Stiffness of materials and laminates are uncoupled, so the ratio between two materials, say, by 20 percent, that ratio is applied to all laminates. Conversely, the ratio between two laminates, say, by 20 percent, that ratio is applied to all materials. Such simple relations can be shown by the rating of 2 tables: one for the trace of materials, and another by DD laminates. Quad laminates do not have such simplicity because their stiffness depend on the number of plies of each family, like 6, 8, 10, and so on. Such single parameter for the strength of laminates can also be found. It is the average the strength of the LPF (last-ply-failure) envelope. Rating of materials and laminates for strength is analogous to that of stiffness. There are at last 15 CFRP materials, and 15 DD laminates. So there are 225 material/laminate combinations. How many tests should be run? Handbook 17 calls for 3 laminates (QI, Hard, Soft) for each material. So for 15 materials there will be 45 combinations. If we know the rating of materials and laminates, only one test for calibration is needed. All other materials and laminates can be scaled. It may be possible to find generic solutions that can cover all materials and laminates by scaling. Trace and average value of LPF can be shown to be functions of fiber stiffness and strength. Then our meso-mechanics model can be based directly from fiber stiffness and strength, and their volume fraction. DD becomes so simple and powerful, and in time will replace Quad.https://cassyni-user-files-prod.s3.amazonaws.com/Ped53tbwBXwdvkH9WTTZnW https://cassyni.com/slides/outline/RWhzQnt6pcAskxeKZ2L7sB https://cassyni.com/events/RWhzQnt6pcAskxeKZ2L7sB/abstract https://cassyni-user-files-prod.s3.amazonaws.com/5gfFCUmdFFAJwfrsCtJKnn https://cassyni.com/events/RWhzQnt6pcAskxeKZ2L7sB?videoPreview=1 Understanding the biosynthesis of starch granules using insights from natural variationnohttps://cassyni.com/events/RWhzQnt6pcAskxeKZ2L7sB?videoPreview=12025-08-07T10:00:00+00:002031.88NoneDespite the fundamental importance of starch to humankind as a major source of calories in our diets, we still do not fully understand how plants make starch. Starch is unique among carbohydrate polymers in that it forms insoluble, semi-crystalline structures called starch granules. While the synthesis of the starch polymers is relatively well understood, we are only beginning to understand how starch granule formation is initiated, and how granule size and shape are determined. Cereal grains such as wheat, rice, and maize contain starch granules with remarkably different morphologies. We have discovered two major factors that underpin this variation. Firstly, we discovered specific proteins that control the initiation of starch granules, which are distinct from the proteins that synthesise the starch polymers. This includes the enzymes starch synthase 4 and plastidial glucan phosphorylase, and their numerous non-catalytic protein interaction partners. Differences in the expression patterns of granule initiation proteins and their protein interactions between species lead to distinct spatio-temporal patterns of granule initiation, which in turn lead to distinct granule morphologies. Secondly, interspecies variation in the morphology, structure and dynamics of the amyloplast, the organelles in which starch granules are produced, plays a major role in creating distinct granule shapes. Disruption of amyloplast structure by mutating components of plastid division can greatly alter the size and shape of starch granules. Our findings advance the understanding of starch granule formation in plants, and using this knowledge, we can now manipulate granule size and shape in wheat to resemble the morphologies found in other crops. This has major implications for improving the nutritional and functional qualities of starch.https://cassyni-user-files-prod.s3.amazonaws.com/5gfFCUmdFFAJwfrsCtJKnn https://cassyni.com/events/JwP9JBPKB2ybGtUdF2pSq/seminar/qa https://cassyni.com/slides/outline/JwP9JBPKB2ybGtUdF2pSq https://cassyni.com/events/JwP9JBPKB2ybGtUdF2pSq/abstract https://cassyni-user-files-prod.s3.amazonaws.com/6qHvRdE9cDVUPvJTmQ5rAa https://cassyni.com/events/JwP9JBPKB2ybGtUdF2pSq?videoPreview=1 Threatened Frogs of southwest Western Australia: status and future in a drying climatenohttps://cassyni.com/events/JwP9JBPKB2ybGtUdF2pSq?videoPreview=12026-02-27T02:15:00+00:003400.44Institute for Applied EcologyFrogs are the most threatened vertebrate group globally, with more than one-third of species at risk of extinction. Western Australia is something of an anomaly, supporting around 83 frog species but with only three species (~4%) being threatened. All three are restricted to the biodiverse southwestone of Australia's fastest drying regions-and confined to isolated peatlands or swampy drainages. Despite these shared vulnerabilities, their conservation management differs markedly. Two species from the Margaret River region are relatively well studied and actively managed, while the Sunset Frog, a monotypic endemic of the Walpole Wilderness, remains comparatively enigmatic. In this talk, I share the stories of these three frogs-their distinctive biology, the challenges of detecting and monitoring them, and emerging research into how a drying climate and other threats may shape their future.https://cassyni-user-files-prod.s3.amazonaws.com/6qHvRdE9cDVUPvJTmQ5rAa https://cassyni.com/slides/outline/3nBQNiR1WToTxDN3AvwTAm https://cassyni.com/events/3nBQNiR1WToTxDN3AvwTAm/abstract https://cassyni-user-files-prod.s3.amazonaws.com/XjjoUeVpzZY7YmUxR2b8TY https://cassyni.com/events/3nBQNiR1WToTxDN3AvwTAm?videoPreview=1 Nano TransMed Youth Forum 2025, Session IVnohttps://cassyni.com/events/3nBQNiR1WToTxDN3AvwTAm?videoPreview=12025-10-31T01:00:00+00:005105.44None[Nano TransMed (NTM)](https://www.keaipublishing.com/en/journals/nano-transmed/) is an open access peer-reviewed journal. To promote cross-boundary research and linkage between nanotechnology and clinical applications, as well as to build an inclusive, barrier-free communication platform for emerging talent in the community, NTM brings together young scholars across the field to share real-time cutting-edge technologies and the latest research findings. 2025 Session IV was held on Oct. 31, 2025. Two speakers shared their latest research.https://cassyni-user-files-prod.s3.amazonaws.com/XjjoUeVpzZY7YmUxR2b8TY https://cassyni.com/slides/outline/BBuU4y7t6L7JSntW8ooBam https://cassyni.com/events/BBuU4y7t6L7JSntW8ooBam/abstract https://cassyni-user-files-prod.s3.amazonaws.com/N1cj1WVkguWvdjsoiAaAea https://cassyni.com/events/BBuU4y7t6L7JSntW8ooBam?videoPreview=1 Editorial Challenges Around AI (Lightning Talk)nohttps://cassyni.com/events/BBuU4y7t6L7JSntW8ooBam?videoPreview=12026-02-24T15:35:00+00:00417.4Researcher to ReaderAs the scholarly publishing landscape evolves, so too do the threats to editorial integrity including manipulated peer review and questionable guest-edited content. Learn how publishers aim to stay ahead of bad actors, the role of technology in protecting trust, and what collaboration across the ecosystem can achieve.https://cassyni-user-files-prod.s3.amazonaws.com/N1cj1WVkguWvdjsoiAaAea https://cassyni.com/slides/outline/J71YqAh7e6np65aUnpJZN5 https://cassyni.com/events/J71YqAh7e6np65aUnpJZN5/abstract https://cassyni-user-files-prod.s3.amazonaws.com/UPnEsEyrTk84L9MFciBWA2 https://cassyni.com/events/J71YqAh7e6np65aUnpJZN5?videoPreview=1 C5 – Managing Internal Funding Awards Using the Microsoft Power Platformnohttps://cassyni.com/events/J71YqAh7e6np65aUnpJZN5?videoPreview=12026-04-20T12:30:00+00:002514.36Research Analytics SummitThe higher education funding landscape is rapidly evolving, placing increasing pressure on research administrators to deliver real – time data, improved service, and greater transparency. This session will demonstrate how to manage the internal funding award process – from faculty application through leadership approval – using the Microsoft Power Platform. You will also receive a behind – the – scenes look at how the University of Washington Vice Provost for Research allocates millions of dollars in funding each year. Beginners will learn how to: Automate the award application, review, and distribution process Build a dashboard to support leadership decision – making for individual applications Create a dashboard that illustrates how funds are distributed across campus Tools featured: Microsoft Excel, Forms, Power Automate, and Power BI (principles also apply to Tableau)https://cassyni-user-files-prod.s3.amazonaws.com/UPnEsEyrTk84L9MFciBWA2 https://cassyni.com/slides/outline/7EkFp8TZz2bsoc8E2G9acV https://cassyni.com/events/7EkFp8TZz2bsoc8E2G9acV/abstract https://cassyni-user-files-prod.s3.amazonaws.com/7H9YDZ4SCTE9yyQL7aaapW https://cassyni.com/events/7EkFp8TZz2bsoc8E2G9acV?videoPreview=1 Let AI Do the Work: Developing Effective Change Management Plansnohttps://cassyni.com/events/7EkFp8TZz2bsoc8E2G9acV?videoPreview=12026-02-24T14:00:00+00:003598.48AAMCThis session explored how generative AI can accelerate and strengthen change management in academic medicine, particularly in environments where traditional planning cycles lag behind rapid transformation. Through a live demonstration, presenters showed how participants could use gen AI to co-develop a practical change management plan and shared ready-to-use templates and resources to support real-world implementation. This webinar is part of the Artificial Intelligence in Academic Medicine Webinar Series, hosted by the AAMC. It explores critical concepts, the current landscape, and practical strategies drawn from various perspectives and institutions to support you in navigating the evolving world of AI in academic medicine. For more information, see [the complete series webpage](https://www.aamc.org/about-us/mission-areas/medical-education/artificial-intelligence-ai-academic-medicine-webinar-series). https://cassyni-user-files-prod.s3.amazonaws.com/7H9YDZ4SCTE9yyQL7aaapW https://cassyni.com/events/E9piThWv8SMfJR7oPhiWmB/abstract https://cassyni-user-files-prod.s3.amazonaws.com/5Jq9QnZTo4QpD4U5m4KHiN https://cassyni.com/slides/outline/Gd4jh7kYKj89fMbMwPd9V7 https://cassyni.com/events/Gd4jh7kYKj89fMbMwPd9V7/abstract https://cassyni-user-files-prod.s3.amazonaws.com/UAYVkk4dqiWHf7rBhcNYn https://cassyni.com/events/Gd4jh7kYKj89fMbMwPd9V7?videoPreview=1 Episode 1: Conversation with Erica Sloannohttps://cassyni.com/events/Gd4jh7kYKj89fMbMwPd9V7?videoPreview=12025-08-19T08:00:00+00:001683.4Advanced ScienceCan stress change cancer pathobiology? That’s one of the questions driving this episode in our new Cancer Neuroscience Symposium Conversation Series - a series of video-podcasts from Wiley’s Advanced Portfolio and the MD Anderson Cancer Center. In this episode, Dr. Erica Sloan (Monash University) joins me and PhD candidate Mekenzie Peshoff (MDACC) to discuss: • Erica’s personal journey – and how it shaped her research • Stress as a driver of cancer biology and immunity • Mind-body science insights into the tumor microenvironment https://cassyni-user-files-prod.s3.amazonaws.com/UAYVkk4dqiWHf7rBhcNYn https://cassyni.com/slides/outline/VTx51X658zT7RpQ2CTfDV7 https://cassyni.com/events/VTx51X658zT7RpQ2CTfDV7/abstract https://cassyni-user-files-prod.s3.amazonaws.com/2TTkb837WkpkJrUJ7ss9vE https://cassyni.com/events/VTx51X658zT7RpQ2CTfDV7?videoPreview=1 Episode 8: A Conversation with Didem Cobanoglunohttps://cassyni.com/events/VTx51X658zT7RpQ2CTfDV7?videoPreview=12025-12-08T09:00:00+00:002776.56Advanced ScienceCancer immunotherapy faces limitations due to complex immunosuppressive mechanisms involving neuroimmune interactions. This research investigates the role of neurotransmitter-producing immune cells and adrenergic signaling in the tumor microenvironment. Stimulation of macrophages, monocytes, and dendritic cells through β2-adrenergic receptors was found to promote an anti-inflammatory state. Exposure to norepinephrine impaired CD8 T cell proliferation and effector functions, reducing production of TNF-α, interferon-γ, and granzyme B, while upregulating PD-1. Macrophage function was suppressed indirectly via cytokine modulation and directly through immunosuppressive IL-10 induction. A key finding from mouse models and human melanoma datasets revealed that conventional anti-CTLA-4 and/or anti-PD-1 therapies robustly increase dopamine β-hydroxylase (DBH)-expressing immune cells, particularly T cells, which produce norepinephrine and contribute to a compensatory immunosuppressive pathway. These observations suggest that combining DBH inhibitors with current checkpoint blockade strategies could enhance anti-tumor responses. The study emphasizes the necessity of understanding systemic neuroimmune interactions, including the gut-brain axis, and addressing the inherent differences between preclinical models and human disease. Future advancements in precision oncology will likely rely on interdisciplinary approaches, leveraging sophisticated *in vitro* organoid cultures and integrating artificial intelligence/machine learning for multimodal data analysis to identify novel therapeutic targets and mitigate immune-related adverse events.https://cassyni-user-files-prod.s3.amazonaws.com/2TTkb837WkpkJrUJ7ss9vE https://cassyni.com/slides/outline/S1QqgjZQ4naUQ86TYoHFxH https://cassyni.com/events/S1QqgjZQ4naUQ86TYoHFxH/abstract https://cassyni-user-files-prod.s3.amazonaws.com/M9d4b5J3AXf8E1Y13rz1Dp https://cassyni.com/events/S1QqgjZQ4naUQ86TYoHFxH?videoPreview=1 The path to no-drift MEMS inertial sensors with on-chip stress calibration nohttps://cassyni.com/events/S1QqgjZQ4naUQ86TYoHFxH?videoPreview=12026-07-22T14:00:00+00:003587.28UK Microsystems NetworkNavigation is vital for the future of autonomous mobility. Data from multiple sensing modalities (GPS, camera, radar, …) are fused in navigation. Among these sensors, inertial navigation is error-proof and can fit into every car and smartphone if a low-cost, no-drift sensor is invented. Drift is a major problem for inertial sensors, limiting their utilization in navigation applications. Inertial sensor data, i.e., acceleration and rotation, is integrated to estimate position, but drift leads to unacceptable position error over time. The common drift suppression approach is temperature calibration, but various studies have shown that it cannot eliminate drift. The drift mechanisms are complex and cannot be fully characterized by simple temperature measurements. So, I propose an on-chip stress calibration approach that directly correlates with the drift. We integrate multiple stress sensors and the MEMS gyroscope on the same chip and achieve state of the art drift performance with on-chip stress sensing. Functional calibration requires deep understanding of the device and temperature effects. I will present our drift solution approach, which includes sensor and electronics design, analytical modeling, and combining temperature and stress measurements. https://cassyni-user-files-prod.s3.amazonaws.com/M9d4b5J3AXf8E1Y13rz1Dp https://cassyni.com/slides/outline/7jRUyScypr5hd57jpNGYnh https://cassyni.com/events/7jRUyScypr5hd57jpNGYnh/abstract https://cassyni-user-files-prod.s3.amazonaws.com/5ezwjcDkymP61UVQdx2Nfx https://cassyni.com/events/7jRUyScypr5hd57jpNGYnh?videoPreview=1 What constrains informal economy Black entrepreneurs from operating businesses more successfully?nohttps://cassyni.com/events/7jRUyScypr5hd57jpNGYnh?videoPreview=12025-11-19T17:30:00+00:001107.12Center for Black Entrepreneurship, Spelman CollegeDespite high entrepreneurial interest and activity among the Black population, underrepresentation in the formal economy leads many to operate within the informal sector, where businesses generally experience less success. This qualitative study investigated constraints on success by conducting structured interviews with 25 Black, non-college-degreed business owners from five distinct geographic locations, generating a dataset of 97 variables. Key findings reveal significant knowledge gaps regarding formal business requirements: 12 owners were unaware of the need for any license or permit, and 20 were unfamiliar with Small Business Administration (SBA) services. Operational practices also varied, with 10 owners conducting no marketing and 15 undertaking no environmental scanning. Cash flow challenges were prevalent among 16 owners, with many relying on intuition or post-occurrence recognition for shortages (10 owners noticed shortages as they occurred) and only five utilizing formal tools like spreadsheets or software for tracking. Profit measurement often relied on intuition or equated sales/cash on hand with profit for 19 owners, while only six employed traditional accounting methods. Regarding education, 19 owners perceived a college degree as unhelpful for their business, though 23 believed a college entrepreneurship course could provide an advantage. Major barriers to college enrollment included time and money. Interviewees requested educational institutions provide more specific business support, up-to-date content, and accessible course offerings. These findings illuminate critical areas where informal Black entrepreneurs lack information, formal support engagement, and systematic business practices, hindering their success. The study highlights the need for tailored educational outreach and accessible resources that directly address identified knowledge and practice gaps to better support this entrepreneurial demographic and inform future policy.https://cassyni-user-files-prod.s3.amazonaws.com/5ezwjcDkymP61UVQdx2Nfx https://cassyni.com/events/4GtFef6JkeD4bNpBAhtbFs/seminar/qa https://cassyni.com/slides/outline/4GtFef6JkeD4bNpBAhtbFs https://cassyni.com/events/4GtFef6JkeD4bNpBAhtbFs/abstract https://cassyni-user-files-prod.s3.amazonaws.com/GTM6b7vFUhMhrsVGTGS4iJ https://cassyni.com/events/4GtFef6JkeD4bNpBAhtbFs?videoPreview=1 Financial Reporting Outlooknohttps://cassyni.com/events/4GtFef6JkeD4bNpBAhtbFs?videoPreview=12026-05-05T04:00:00+00:005296.04SACLIn this presentation, Dr Andreas Barckow, Chair of the International Accounting Standards Board, will share insights into the IASB’s current work programme and the broader financial reporting outlook. The presentation will highlight areas on the international agenda which may be of research interest such as accounting for intangible assets, user interaction with financial statements, the upcoming implementation of IFRS 18 Presentation and Disclosure in Financial Statements, segment reporting, and pollutant pricing mechanisms.https://cassyni-user-files-prod.s3.amazonaws.com/GTM6b7vFUhMhrsVGTGS4iJ https://cassyni.com/slides/outline/EeVwd1gKyFqV7t7KBoqUwP https://cassyni.com/events/EeVwd1gKyFqV7t7KBoqUwP/abstract https://cassyni-user-files-prod.s3.amazonaws.com/5LuMb9pwAiNUkeAoEJh7Fk https://cassyni.com/events/EeVwd1gKyFqV7t7KBoqUwP?videoPreview=1 Organic Reticular Membranes: Design to Applicationsnohttps://cassyni.com/events/EeVwd1gKyFqV7t7KBoqUwP?videoPreview=12026-03-27T09:00:00+00:003485.56Thieme India ChemTalksReticular chemistry, which involves linking inorganic or organic building blocks through strong covalent bonds, enables the rational design of extended porous structures. While metal-organic frameworks (MOFs) offer high porosity and tunability, they can exhibit chemical instability or contain heavy elements. Covalent organic frameworks (COFs) address these challenges, presenting crystalline, porous, and chemically stable organic materials suitable for membrane applications. This abstract details the design and application of organic reticular membranes, including COF-based systems and novel Nanoparticle Organic Networks (NONs). Various interfacial polymerization techniques were employed for membrane fabrication. A super-oleophilic membrane demonstrated efficient oil-water separation with fluxes up to 3,300 L·m⁻²·h⁻¹ and consistent water rejection over five cycles. Amphiphilic organic membranes were developed for anti-fouling emulsified oil separation, achieving gravity-driven fluxes near 2,500–3,000 L·m⁻²·h⁻¹ with demonstrated reusability. COF membranes incorporating phosphorothioate catalytic cores served as reusable heterogeneous catalysts for COF formation. A three-layer dual interfacial approach enabled the one-pot synthesis of two distinct membranes, which exhibited semiconducting properties (band gap 2.3–2.5 eV) and high terahertz (THz) transparency (>70%), along with extractable optical conductivity parameters. Furthermore, temperature-assisted interfacial polymerization facilitated the creation of membranes with carbon-carbon bonds, demonstrating superior nonlinear optical properties. A new material class, Nanoparticle Organic Networks (NONs), was introduced, where metal nanoparticles (e.g., Ag, Au, ~10 nm) with a zero oxidation state are covalently linked by organic components. Hybrid silver NON membranes, supported on COFMs, were successfully applied as working electrodes for hydrogen evolution, showing an overpotential of ~350 mV and visible kinetics. This work highlights the versatility of organic reticular membranes for diverse applications in molecular separation, heterogeneous catalysis, optoelectronics, and as a foundation for next-generation "memtronic" devices and sensors.https://cassyni-user-files-prod.s3.amazonaws.com/5LuMb9pwAiNUkeAoEJh7Fk https://cassyni.com/slides/outline/H7may4RqZuY2N9CgPcXzV3 https://cassyni.com/events/H7may4RqZuY2N9CgPcXzV3/abstract https://cassyni-user-files-prod.s3.amazonaws.com/WhvuKNUFQFL6PygLA3oJPG https://cassyni.com/events/H7may4RqZuY2N9CgPcXzV3?videoPreview=1 The First Cleaner Ant? A Novel Partnership in the Arizona Desertnohttps://cassyni.com/events/H7may4RqZuY2N9CgPcXzV3?videoPreview=12026-05-29T15:21:05+00:00285.12Ecology and Evolution Hear how Dr. Mark Moffett discovered a unique interaction between two ant species and documented it in a Nature Note published in Ecology and Evolution. Recently highlighted in the New York Times, this work underlines the importance of observation in ecology and as Dr. Moffett says, “keep your eyes open, you never know what you’re going to see!” https://www.nytimes.com/2026/04/13/science/harvester-cone-ants-cleaning.htmlhttps://cassyni-user-files-prod.s3.amazonaws.com/WhvuKNUFQFL6PygLA3oJPG https://cassyni.com/slides/outline/SzjftjNLM4cMDfChuBJMcy https://cassyni.com/events/SzjftjNLM4cMDfChuBJMcy/abstract https://cassyni-user-files-prod.s3.amazonaws.com/PVos12MvCfhR682DH3s2gv https://cassyni.com/events/SzjftjNLM4cMDfChuBJMcy?videoPreview=1 KeAi Talk: ISWCR Series IV_Prof. Giulio Castellinohttps://cassyni.com/events/SzjftjNLM4cMDfChuBJMcy?videoPreview=12026-04-21T01:00:00+00:001053.12NoneNature-based Solutions and Modelling Innovations for Sustainable Soil and Water Management under Climate Extremes [International Soil and Water Conservation Research (ISWCR)](https://www.keaipublishing.com/en/journals/international-soil-and-water-conservation-research/), the official journal of the [World Association of Soil and Water Conservation (WASWAC)](http://www.waswac.org.cn), is a multidisciplinary journal for soil and water conservation research, practice, policy, and perspectives. This journal aims to disseminate new knowledge and promote the practice of soil and water conservation. https://cassyni-user-files-prod.s3.amazonaws.com/PVos12MvCfhR682DH3s2gv https://cassyni.com/slides/outline/DAakbbFe4F6saUjzzVwwt9 https://cassyni.com/events/DAakbbFe4F6saUjzzVwwt9/abstract https://cassyni-user-files-prod.s3.amazonaws.com/EvkLMb6DaDZYoU5CVW3tce https://cassyni.com/events/DAakbbFe4F6saUjzzVwwt9?videoPreview=1 Introduction to the JVI Seminar Seriesnohttps://cassyni.com/events/DAakbbFe4F6saUjzzVwwt9?videoPreview=12025-01-21T13:00:00+00:002694.08Journal of VirologyJoin Felicia Goodrum, PhD, and Stacey Schultz-Cherry, PhD, co-Editors in Chief of the Journal of Virology (JVI), for the debut episode of the JVI Seminar Series! In the first webinar of the series, Drs. Goodrum and Schultz-Cherry share their vision and goals for future episodes, explaining why the series was created and what it hopes to achieve. Learn how you can get involved in future webinars, explore upcoming topics, and connect with a platform dedicated to showcasing groundbreaking virology research and discussions. Don’t miss the chance to catch up on this must-watch event! Learning Objectives: • A preview of upcoming hot topics and renowned presenters. • The latest breakthroughs and trends in virology—stay ahead of the curve! • The grand challenges in virology—understand tomorrow’s toughest questions today! • Insider tips on getting your research published.https://cassyni-user-files-prod.s3.amazonaws.com/EvkLMb6DaDZYoU5CVW3tce https://cassyni.com/slides/outline/CBHYWDxbBKziuiuztXUd5F https://cassyni.com/events/CBHYWDxbBKziuiuztXUd5F/abstract https://cassyni-user-files-prod.s3.amazonaws.com/4KpLkkbo32T7y9eGzpdGh4 https://cassyni.com/events/CBHYWDxbBKziuiuztXUd5F?videoPreview=1 Can Machine Learning Discover Closure Relations in Plasma Physics?nohttps://cassyni.com/events/CBHYWDxbBKziuiuztXUd5F?videoPreview=12026-06-18T15:00:00+00:002702.36Journal of Plasma PhysicsFluid models provide an efficient framework for plasma simulations but rely on closure relations to capture kinetic effects. In this work, we present a data-driven plasma fluid closure for one-dimensional electrostatic Landau damping in both the linear and nonlinear regimes. The closure is represented by a Fourier Neural Operator (FNO) trained *online* within a differentiable fluid solver. Rather than learning from individual kinetic snapshots, the model is optimized using losses computed from entire trajectories generated by the closed fluid simulation, enabling it to learn closures that remain accurate when coupled to the fluid dynamics. We show that a single trained FNO accurately reproduces both linear and nonlinear Landau damping, generalizes to perturbation amplitudes beyond those used during training, and remains numerically stable in independent fluid simulations. These results highlight the potential of machine learning as a tool for discovering robust closure relations and bridging kinetic and fluid descriptions in plasma physics. https://cassyni-user-files-prod.s3.amazonaws.com/4KpLkkbo32T7y9eGzpdGh4 https://cassyni.com/slides/outline/VxevHTmNPAri5HS1A5DgoP https://cassyni.com/events/VxevHTmNPAri5HS1A5DgoP/abstract https://cassyni-user-files-prod.s3.amazonaws.com/4UX13CJ2bBXdCMeYYMDcE2 https://cassyni.com/events/VxevHTmNPAri5HS1A5DgoP?videoPreview=1 Extending the thermal limits of life: thermal tolerance and life history of grasses from extremely hot geothermal areasnohttps://cassyni.com/events/VxevHTmNPAri5HS1A5DgoP?videoPreview=12026-06-02T14:40:00+00:00705.52Geothermal areas are formed where Earth’s inner heat is transported to the surface, resulting in peculiar formations including fumaroles, geysers and hot streams and soils. These places are high stress, low diversity environments, with the main factor limiting the presence of most life there being heat. In addition, most geothermal areas are found at high elevations or latitudes, meaning that the surrounding non-thermal areas can get bitterly cold, and creating sharp thermal gradients from scorching to freezing over short geographic distances. Thus, geothermal areas constitute natural laboratories for studying adaptation to thermal extremes. Here, we present grasses (Poaceae) occurring at extremely hot (<70˚C) sites across several geothermal areas. Specifically, we present ongoing research on life history shifts in response to geothermal heat and the consequence of adapting to extreme heat on performance under cooler conditions. Preliminary results point to different adaptive strategies for different species in different geothermal areas, suggesting that there are multiple routes to extending the thermal limits of life, even among closely related species. Our research also challenges the idea of shared upper thermal limits across the eukaryote Tree of Life.https://cassyni-user-files-prod.s3.amazonaws.com/4UX13CJ2bBXdCMeYYMDcE2 https://cassyni.com/events/TVQu43XkBt6B38CDhHRKoB/abstract https://cassyni-user-files-prod.s3.amazonaws.com/GcMnnrBZCa19ZAc7Lsddc2 https://cassyni.com/slides/outline/ACikS7tNpri4NFRx8wgxXX https://cassyni.com/events/ACikS7tNpri4NFRx8wgxXX/abstract https://cassyni-user-files-prod.s3.amazonaws.com/3p5NUKVFVLKoKpZJdWZPJW https://cassyni.com/events/ACikS7tNpri4NFRx8wgxXX?videoPreview=1 Science Advocacy in Action: Hantaviruses in the Wildnohttps://cassyni.com/events/ACikS7tNpri4NFRx8wgxXX?videoPreview=12026-06-23T17:00:00+00:00395.6Journal of VirologyZoonotic viruses represent a significant threat to human health, underscoring the critical need to understand their biology within natural reservoir hosts. Traditional laboratory infection models are often insufficient for this purpose, necessitating a shift towards more ecologically realistic approaches. This study advocates for the use of experimental infection models featuring authentic virus-host pairings, complemented by observational trap-and-release field studies. Such systems are shown to more effectively capture the intricate host-virus interactions that drive viral persistence and transmission within reservoirs, thereby providing crucial insights into spillover mechanisms to humans. The presented primary studies, integrated with findings from a mini-review, offer guidance on optimal strategies for investigating infection processes in natural hosts. A key unresolved question in the field pertains to the restricted geographic distribution of certain rodent-borne viruses, exemplified by Lassa virus, which primarily emerges in West Africa despite its reservoir host being broadly distributed across the African continent. Addressing such questions through advanced experimental models is paramount. Ultimately, a deeper understanding of these intimate virus-host interactions, particularly the identification of critical “choke points” in the viral life cycle, is essential for developing broad-spectrum antivirals and effective vaccines, moving beyond pathogen-specific treatments.https://cassyni-user-files-prod.s3.amazonaws.com/3p5NUKVFVLKoKpZJdWZPJW https://cassyni.com/events/BgiooRriwxDkzwwsKbDh9F/abstract https://cassyni-user-files-prod.s3.amazonaws.com/J1oQU7vsqeV8kvzCeo9b6v https://cassyni.com/events/Q3QVuDnumXoyNSSfBm8bnm/abstract https://cassyni-user-files-prod.s3.amazonaws.com/GkXf7GQmyiTPNRjKZ4DCGW https://cassyni.com/events/JcGrPhg8wVityaCRar8ooK/abstract https://cassyni-user-files-prod.s3.amazonaws.com/GPTkqG5bpBxfyr1LAEU4Wz https://cassyni.com/events/JcGrPhg8wVityaCRar8ooK?videoPreview=1 Transforming diagnosis through artificial intelligence nohttps://cassyni.com/events/JcGrPhg8wVityaCRar8ooK?videoPreview=12026-09-25T16:00:00+00:002246.04npj Digital Medicine Artificial intelligence is increasingly permeating the fabric of medicine, but getting its full benefits will likely require fundamental changes in practice. https://cassyni-user-files-prod.s3.amazonaws.com/GPTkqG5bpBxfyr1LAEU4Wz https://cassyni.com/slides/outline/K6vTSPKfNxGwyLjKBHRc4d https://cassyni.com/events/K6vTSPKfNxGwyLjKBHRc4d/abstract https://cassyni-user-files-prod.s3.amazonaws.com/9Cmqfk47dWLGXtt1vLyNr2 https://cassyni.com/events/K6vTSPKfNxGwyLjKBHRc4d?videoPreview=1 Extending the double adiabatic equations to the relativistic regimenohttps://cassyni.com/events/K6vTSPKfNxGwyLjKBHRc4d?videoPreview=12026-09-17T15:00:00+00:002713.92Journal of Plasma PhysicsIn this talk I will present our results on extending the double-adiabatic equations to the relativistic and ultrarelativistic regimes. In a collisionless, magnetized plasma, the pressure components across and along the direction of the magnetic field decouple and evolve independently. In conditions where the particle adiabatic invariants are conserved, Chew, Goldberger and Low 1956 gave state equations for the perpendicular and parallel pressures valid in the nonrelativistic regime (also known as "CGL"). In our case, by analytically solving the relativistic, homogeneous, time-dependent drift kinetic equation, we obtain a general solution for the particle distribution function, explicitly dependent on the magnetic field and density variations. In the particular case of an initial relativistic, isotropic Maxwellian distribution, we calculate the moments of this time-dependent solution and obtain analytical expressions for the evolution of the perpendicular and parallel pressures in the ultrarelativistic case, and numerically integrate the moments in the relativistic case. The obtained solution also serves as a newly proposed relativistic anisotropic Maxwell-Jüttner distribution. We validate our results using fully kinetic particle-in-cell simulations of shearing and compressing boxes. These results can be readily applied to relativistic species including cosmic rays and electron–positron pairs, present in astrophysical plasmas like pulsar wind nebulae, astrophysical jets, black hole accretion flows and Van Allen radiation belts.https://cassyni-user-files-prod.s3.amazonaws.com/9Cmqfk47dWLGXtt1vLyNr2 https://cassyni.com/slides/outline/UVEwKNcdieoDq6CT6QuAwF https://cassyni.com/events/UVEwKNcdieoDq6CT6QuAwF/abstract https://cassyni-user-files-prod.s3.amazonaws.com/AXeuQVKjoWNQyNJcvo4TYz https://cassyni.com/events/UVEwKNcdieoDq6CT6QuAwF?videoPreview=1 MedBiquitous Program Updatesnohttps://cassyni.com/events/UVEwKNcdieoDq6CT6QuAwF?videoPreview=12026-09-16T17:00:00+00:003549.88AAMCLearn the latest about the [MedBiquitous](https://www.medbiq.org/) advisory committees and working groups, gain insight into current initiatives across our community, and discover upcoming projects and opportunities to engage, including through future work in educational methodology, simulation, AI, data governance, and discover opportunities to contribute.https://cassyni-user-files-prod.s3.amazonaws.com/AXeuQVKjoWNQyNJcvo4TYz https://cassyni.com/events/7k1ZNfSbHRXxh6kApHyq3j/abstract https://cassyni-user-files-prod.s3.amazonaws.com/L8FijDPAfeYPhx3XawQovE https://cassyni.com/events/9ibyZQ2h3Fkinp2QBFqmUH/abstract https://cassyni-user-files-prod.s3.amazonaws.com/KtrULyHTPJL5ayoCUggcRU https://cassyni.com/events/FfN27dq1QNpL1ocYzHkCvR/seminar/qa https://cassyni.com/slides/outline/FfN27dq1QNpL1ocYzHkCvR https://cassyni.com/events/FfN27dq1QNpL1ocYzHkCvR/abstract https://cassyni-user-files-prod.s3.amazonaws.com/VJ5j9MeZC4vvBzDWd8Rrpe https://cassyni.com/events/FfN27dq1QNpL1ocYzHkCvR?videoPreview=1 Ensuring Equity in Open Accessnohttps://cassyni.com/events/FfN27dq1QNpL1ocYzHkCvR?videoPreview=12024-10-23T08:00:00+00:003447.52Topics at the heart of our communityIn the transition towards open access (OA), commitment to equity and accessibility is key to ensuring global participation and representation are included in OA strategies. While there are still central challenges to bridging these gaps in OA, there are several ways these barriers are increasingly being broken. Join Caroline Nevison, Director of Open Access Agreements, in conversation with Sarah Phibbs, Director of Research4Life Publisher Partnerships, to discuss the progress towards providing OA opportunities more broadly in research.https://cassyni-user-files-prod.s3.amazonaws.com/VJ5j9MeZC4vvBzDWd8Rrpe https://cassyni.com/slides/outline/NZ6bGz9pDU7ETGW6wmPGww https://cassyni.com/events/NZ6bGz9pDU7ETGW6wmPGww/abstract https://cassyni-user-files-prod.s3.amazonaws.com/C6UBRDcoUfdXNatgKV8H9x https://cassyni.com/events/NZ6bGz9pDU7ETGW6wmPGww?videoPreview=1 Foundations of Skill-Building with Artificial Intelligencenohttps://cassyni.com/events/NZ6bGz9pDU7ETGW6wmPGww?videoPreview=12025-05-15T08:00:00+00:003555.04AAMCCurious about AI but not sure where to start? This session lays the groundwork for building your confidence and skill with artificial intelligence in medical education. We’ll break down essential concepts like machine learning, natural language processing, and data pipelines in clear, practical terms. You'll get comfortable with key terminology, explore the differences between AI and Generative AI (GenAI), and discuss ethical guidelines for responsible AI use in academic settings. You’ll also have the opportunity to self-assess your current AI competency and set goals for growth. Whether you’re a beginner or looking to solidify your foundation, this session will equip you with the knowledge you need to move forward with confidence. Objectives: - Explain the fundamental concepts of AI, including machine learning, natural language processing, and data pipelines. - Define key AI terminology relevant to medical education. - Compare AI and Generative AI (GenAI). - Identify ethical considerations and guidelines for AI use in academia. - Self-assess AI competency in medical education This webinar is part of the AI Skill Building for Medical Educators Webinar Series, hosted by the AAMC. For more information, see [the complete series webpage](https://www.aamc.org/learn-network/affinity-groups/group-educational-affairs/webinar-series-ai-skill-building-medical-educators).   CME Information - View the last page of the slide deck for complete instructions on earning CME credit for this recording - CME credit for this learning opportunity is organized by Michigan State University College of Human Medicine Office of Continuing Medical Education - You will be prompted to create an account to obtain credithttps://cassyni-user-files-prod.s3.amazonaws.com/C6UBRDcoUfdXNatgKV8H9x https://cassyni.com/slides/outline/3ormEVLBg7P4mbQiyYjx6Z https://cassyni.com/events/3ormEVLBg7P4mbQiyYjx6Z/abstract https://cassyni-user-files-prod.s3.amazonaws.com/5z6eiZHgvXSLKcGYQ5LJLN https://cassyni.com/events/3ormEVLBg7P4mbQiyYjx6Z?videoPreview=1 LNL Workshop: Building LNL Open Research Enabler Relationshipsnohttps://cassyni.com/events/3ormEVLBg7P4mbQiyYjx6Z?videoPreview=12024-03-07T03:00:00+00:002998.52UKRNBoth LNLs and open research enablers face challenges in how best to find/reach researchers in other disciplines and bring them into local network open research activities, and in how best to advertise events within departments and faculties. This workshop brings together LNLs and open research enablers, including ORCAs (Open Research Coordinators & Administrators based at institutes involved in the UKRN Open Research Programme) to share their experiences and advice.https://cassyni-user-files-prod.s3.amazonaws.com/5z6eiZHgvXSLKcGYQ5LJLN https://cassyni.com/events/XwDiMZqaje9Nckv3uf1MM7/abstract https://cassyni-user-files-prod.s3.amazonaws.com/S96RdnJWdxWwuhDen4aMPU https://cassyni.com/events/4nWehNmrHjBbRojwLfQZwj/seminar/qa https://cassyni.com/slides/outline/4nWehNmrHjBbRojwLfQZwj https://cassyni.com/events/4nWehNmrHjBbRojwLfQZwj/abstract https://cassyni-user-files-prod.s3.amazonaws.com/4wA2ZTfusdDg2PYMuiqjp2 https://cassyni.com/events/4nWehNmrHjBbRojwLfQZwj?videoPreview=1 Ecological Radiations of Mammals: Before & After the K/Pg Mass Extinctionnohttps://cassyni.com/events/4nWehNmrHjBbRojwLfQZwj?videoPreview=12024-10-10T16:00:00+00:002188.04Cambridge PrismsThe research in the Wilson Lab aims to understand critical transitions in the deep-time history of life. One of the most captivating of these transitions is the early evolutionary radiation of mammals, which ultimately led to their striking diversity today, from the tiny bumblebee bat to the titanic blue whale. Specifically, we focus on how mammals evolved during the Mesozoic Era (220 to 66 million years ago), when major mammal groups originated, and fundamental changes in the anatomy, physiology, and ecology of mammals occurred. We combine paleontological and geological field work, description and systematic study of fossil specimens, and quantitative analysis of morphology, function, and ecology of extant and extinct taxa. This work elucidates the paleoecology and macroevolution of early mammals in the context of dinosaur-dominated terrestrial ecosystems, the breakup of Pangaea, and the end-Cretaceous mass extinction. In this seminar, I will summarize results from three research areas that span ecological scales from individual taxa to communities and ecosystems. A broader understanding of such ecological dynamics through time is critical to our understanding of the processes that govern ecosystem assembly and maintenance, topics that directly bear on efforts to forecast and mitigate the evolutionary and ecological consequences of our current biodiversity crisis. https://cassyni-user-files-prod.s3.amazonaws.com/4wA2ZTfusdDg2PYMuiqjp2 https://cassyni.com/slides/outline/2JdJqUgqq97PfTaPXD37t9 https://cassyni.com/events/2JdJqUgqq97PfTaPXD37t9/abstract https://cassyni-user-files-prod.s3.amazonaws.com/2jTh6wYuHYKuiZNMKapGni https://cassyni.com/events/2JdJqUgqq97PfTaPXD37t9?videoPreview=1 A Free Verse of Foodnohttps://cassyni.com/events/2JdJqUgqq97PfTaPXD37t9?videoPreview=12021-04-22T12:00:00+00:00157.84Hong Kong Baptist UniversityJun Pan reads, from Hong Kong, 'A Free Verse of Food' for the Proverse Spring Reception 2021, assisted by a friend.https://cassyni-user-files-prod.s3.amazonaws.com/2jTh6wYuHYKuiZNMKapGni https://cassyni.com/slides/outline/Fe8d5wA1gW4MYfsygSBSYu https://cassyni.com/events/Fe8d5wA1gW4MYfsygSBSYu/abstract https://cassyni-user-files-prod.s3.amazonaws.com/GrYsAjPwpQtJw16rZrXSez https://cassyni.com/events/Fe8d5wA1gW4MYfsygSBSYu?videoPreview=1 Interview 12 - Dr. Cindy Yik-yi Chunohttps://cassyni.com/events/Fe8d5wA1gW4MYfsygSBSYu?videoPreview=12020-12-23T12:00:00+00:002952.2Hong Kong Baptist UniversityNo abstracthttps://cassyni-user-files-prod.s3.amazonaws.com/GrYsAjPwpQtJw16rZrXSez https://cassyni.com/slides/outline/TVGnUtxKB5TYJS8NJc7nQu https://cassyni.com/events/TVGnUtxKB5TYJS8NJc7nQu/abstract https://cassyni-user-files-prod.s3.amazonaws.com/NGxKht7gB4tYD8Ne6rvUML https://cassyni.com/events/TVGnUtxKB5TYJS8NJc7nQu?videoPreview=1 Toolbox International Creative Academy 2021nohttps://cassyni.com/events/TVGnUtxKB5TYJS8NJc7nQu?videoPreview=12021-01-08T12:00:00+00:005671.04Hong Kong Baptist UniversityTICA 2021 is financially supported by the Arts Capacity Development Funding Scheme of the Government of the Hong Kong Special Administrative Region. Echoing its major tone for innovative performative techniques for percussion and string, the panel discussion will be led by three musicians from different fields, Dr. Fung Lam, Dr. Matthew Schreibeis and Timothy Page, the topic of innovative composition technique will be analysed and discussed.https://cassyni-user-files-prod.s3.amazonaws.com/NGxKht7gB4tYD8Ne6rvUML https://cassyni.com/slides/outline/2nraAic5EBmb8yqdnPXgjF https://cassyni.com/events/2nraAic5EBmb8yqdnPXgjF/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Aeo5M3QbZuKdVqf5HqfWez https://cassyni.com/events/2nraAic5EBmb8yqdnPXgjF?videoPreview=1 Whisper Listen Whispernohttps://cassyni.com/events/2nraAic5EBmb8yqdnPXgjF?videoPreview=12020-03-07T12:00:00+00:00569.4Hong Kong Baptist UniversityThis video explains the mechanism that was created by arts educators Robert Manners and Michael Whittle into a game to facilitate the creative unknown as a working methodology between BA (Hons) Painting Drawing & Printmaking students from Plymouth College of Art, UK, and BA Sculpture students from The Academy of Visual Arts, HKBU, Hong Kong.https://cassyni-user-files-prod.s3.amazonaws.com/Aeo5M3QbZuKdVqf5HqfWez https://cassyni.com/slides/outline/4msL4tvU2Rst2Q3x4twkc5 https://cassyni.com/events/4msL4tvU2Rst2Q3x4twkc5/abstract https://cassyni-user-files-prod.s3.amazonaws.com/WokhGXMyc9pXzTR7Azg42r https://cassyni.com/events/4msL4tvU2Rst2Q3x4twkc5?videoPreview=1 Dr. Boone & Fr. Rooney on 'Severance', John Locke, Ringworms, and the Final Judgment (discussion)nohttps://cassyni.com/events/4msL4tvU2Rst2Q3x4twkc5?videoPreview=12025-05-06T12:00:00+00:003511.04Hong Kong Baptist UniversityThis seminar explores the philosophical and theological dimensions of personal identity as dramatized in the TV show *Severance*. The discussion foregrounds the show’s unique focus on memory as the central criterion for personal identity, contrasting it with classical thought experiments such as John Locke’s “Day Man/Night Man,” which similarly consider discontinuities of memory and consciousness within a single body. The analysis critiques psychological continuity theories that equate personal identity solely with memory, highlighting challenges in defining objective continuity amid manipulated or severed memories. An organism-based or hylomorphic account of identity is advanced, emphasizing the unity of the human being as a composite of body and soul, which persists despite memory alterations. The seminar further interrogates moral responsibility in cases of memory disruption, arguing that loss of memory does not absolve one’s moral culpability, and that genuine redemption requires confronting rather than erasing past wrongs. The show’s portrayal of “Innies” and “Outies”—distinct memory states within one person—raises ethical questions about consent, abuse, and the plausibility of severance as a therapeutic intervention, especially for trauma survivors. Theological reflections engage with Locke’s linkage of memory continuity to divine judgment, proposing that divine omnipotence could reconcile identity and judgment beyond human conceptual limits. Ultimately, reintegration of severed memories is proposed as a morally preferable resolution, though selective memory erasure may be ethically justifiable in extreme cases of abuse. This interdisciplinary inquiry illuminates the complex interplay between memory, identity, morality, and theology in contemporary speculative narratives.https://cassyni-user-files-prod.s3.amazonaws.com/WokhGXMyc9pXzTR7Azg42r https://cassyni.com/slides/outline/DAtbrWvPVDHsBjQR8kGopy https://cassyni.com/events/DAtbrWvPVDHsBjQR8kGopy/abstract https://cassyni-user-files-prod.s3.amazonaws.com/6Y8AbUGmAQMu4yDofVb8dk https://cassyni.com/events/DAtbrWvPVDHsBjQR8kGopy?videoPreview=1 Artificial Dignity: AI and the Status of Non-Person Humansnohttps://cassyni.com/events/DAtbrWvPVDHsBjQR8kGopy?videoPreview=12023-07-11T12:00:00+00:005220.72Hong Kong Baptist UniversityIn July 2022, The Center for Theology and the Natural Sciences (CTNS) announced the start of a new three-year research project funded by the John Templeton Foundation. The research titled "Virtuous AI?: Cultural Evolution, Artificial Intelligence, and Virtue" will focus on Artificial Intelligence (AI), its cultural and ethical implications, how this could impact human virtue, and how we might envision AI and virtue. More information about the new project can be found on the CTNS website. As part of the new project, CTNS is hosting three online conferences in the summer of 2023. The conferences will be focused on time zones centered on Seoul, Berkeley, and Rome. This is to encourage participation by scientists, engineers, and humanities scholars from a wide variety of scientific, religious, and philosophical perspectives, cultural traditions, and geographic locations interested in the intersection between AI and virtue.https://cassyni-user-files-prod.s3.amazonaws.com/6Y8AbUGmAQMu4yDofVb8dk https://cassyni.com/slides/outline/CBbPm9dLcJBiWyaR2moV25 https://cassyni.com/events/CBbPm9dLcJBiWyaR2moV25/abstract https://cassyni-user-files-prod.s3.amazonaws.com/LYt5DDgM6xw3HEWJUzACeS https://cassyni.com/events/CBbPm9dLcJBiWyaR2moV25?videoPreview=1 General Elections explained: What is a 'Freak Election'?nohttps://cassyni.com/events/CBbPm9dLcJBiWyaR2moV25?videoPreview=12025-04-14T12:00:00+00:00296.2Hong Kong Baptist UniversityWhat is a ‘Freak Election’? Cherian George (Hong Kong Baptist University) breaks it down in the first of our GE2025 explainer series, where academics unpack key concepts in Singapore politics. Dive into our GE2025 resource page for open-access scholarly readings and insights on Singapore’s political system—including an article on freak elections.https://cassyni-user-files-prod.s3.amazonaws.com/LYt5DDgM6xw3HEWJUzACeS https://cassyni.com/slides/outline/NYnk24V4nVvEr1qgoX4R17 https://cassyni.com/events/NYnk24V4nVvEr1qgoX4R17/abstract https://cassyni-user-files-prod.s3.amazonaws.com/7hVXqV4s3CweNEz2XbCDCS https://cassyni.com/events/NYnk24V4nVvEr1qgoX4R17?videoPreview=1 The Problem of Evilnohttps://cassyni.com/events/NYnk24V4nVvEr1qgoX4R17?videoPreview=12021-08-28T12:00:00+00:0013667.88Hong Kong Baptist UniversityAddressing the pervasive philosophical problem of evil, this seminar explores various facets of its challenge to theistic belief. The moral argument for God's existence is advanced, contending that the objective reality of moral laws, such as the inherent wrongness of cruelty or goodness of benevolence, cannot be satisfactorily explained by naturalistic accounts (e.g., sociobiology, social contract theory). Instead, objective morality is best grounded in God's loving and benevolent nature, serving as an abductive inference for theism that balances the problem of evil. Additionally, the issue of natural evil before the Fall is examined, proposing an old-earth creationist perspective consistent with biblical texts that allows for animal death and extinction prior to human sin. It is suggested that Genesis portrays a "very good" but not yet "perfect" creation, requiring human stewardship, and that some natural evils may be linked to the destructive actions of fallen angels. The nature of animal suffering is further nuanced, noting that neural complexity may limit the extent of pain experienced by some creatures, with potential future redemption offering ultimate compensation. Finally, the contentious issue of Old Testament ethnic wars is addressed through a hyperbolic reading of 'herem' (dedication to destruction) language in texts like Joshua and 1 Samuel. Internal literary analysis and Ancient Near Eastern conquest rhetoric indicate that these accounts describe exaggerated victories and commands to drive out inhabitants and purge idolatry, rather than literal genocide of all non-combatants, thereby affirming God's moral justification and preserving the coherence of biblical narrative.https://cassyni-user-files-prod.s3.amazonaws.com/7hVXqV4s3CweNEz2XbCDCS https://cassyni.com/slides/outline/P3SM4k8bDxUHqnNaPxMDGR https://cassyni.com/events/P3SM4k8bDxUHqnNaPxMDGR/abstract https://cassyni-user-files-prod.s3.amazonaws.com/9GeAbxa5vAQDs295X1UWCN https://cassyni.com/events/P3SM4k8bDxUHqnNaPxMDGR?videoPreview=1 Online launch of Where Else: An International Hong Kong Poetry Anthologynohttps://cassyni.com/events/P3SM4k8bDxUHqnNaPxMDGR?videoPreview=12023-04-27T12:00:00+00:002988.12Hong Kong Baptist UniversityThis online launch of Where Else: An International Hong Kong Poetry Anthology was co-ordinated by Oxford Brookes Poetry Centre and featured readings by Sophie Lau, Jason Eng Hun Lee, Jerrold Yam, Tim Tim Cheng, Mary Jean Chan, and Louise Leung. Eric Yip also read at the event, but doesn't appear in the video. The launch was introduced by Jason Eng Hun Lee, who along with Tim Tim Cheng and Jennifer Wong, edited the anthology, which is published by Verve Poetry Press. Featuring both established and emerging Hong Kong poets across generations and continents, Where Else: An International Hong Kong Poetry Anthology, offers a glimpse into an exciting, diverse range of voices that make up the diasporic imagination of the contemporary Hong Kong poetry community. Adopting a diasporic approach, the anthology encompasses both native Hong Kong writers as well as expatriate and mixed-race voices who were born or have lived in the city. The anthology sheds light on some poignant, wide-ranging themes such as migration, identity, gender, language, belonging, environment that underpin the city of Hong Kong, a place situated uniquely between the East and the West, in the 21st century. The book also features a selection of artworks from some of Hong Kong’s most talented artists, inviting the reader to make connections between the visual images and the text.https://cassyni-user-files-prod.s3.amazonaws.com/9GeAbxa5vAQDs295X1UWCN https://cassyni.com/slides/outline/HcJhZE1pPvPDSv8Lo3MRGy https://cassyni.com/events/HcJhZE1pPvPDSv8Lo3MRGy/abstract https://cassyni-user-files-prod.s3.amazonaws.com/CiLi8XvNG4zPyHswTdreSS https://cassyni.com/events/HcJhZE1pPvPDSv8Lo3MRGy?videoPreview=1 Anti-Colonial Praxes in and Beyond Global Asiasnohttps://cassyni.com/events/HcJhZE1pPvPDSv8Lo3MRGy?videoPreview=12024-11-12T12:00:00+00:005206.2Hong Kong Baptist UniversityConceptual frameworks such as “Inter-Asia,” “the Asian Sixties,” “Afro-Asia,” and “Global Maoism”—with their distinct genealogies, possibilities, and limitations—emerged to remediate the assumption of Asia as a bounded unit, shared in both Orientalist and Cold War paradigms of Asian studies. Not only do they understand Asia relationally, connecting divergent locations of differing scales within and outside of “Asia” – or more accurately, “Global Asias,” but they also concern worldmaking political praxes and imaginaries that orient towards internationalism, decolonization, and socialism. This event further probes the political work of these conceptual frames in the current conjuncture of the Chimerica antagonistic cooperation. It seeks to address hitherto understudied and possibly more rigorous ways to articulate anticolonial praxes in and beyond global Asias by being attentive to internationalist solidarity-making efforts that seriously consider race, gender, and indigeneity. This roundtable brings together emerging and established scholars to discuss these timely questions in the Global Asian humanities, reflect on the state of the field, and propose preliminary future research directions.https://cassyni-user-files-prod.s3.amazonaws.com/CiLi8XvNG4zPyHswTdreSS https://cassyni.com/slides/outline/VxWoiKBwNNE5LbN9mPv9R7 https://cassyni.com/events/VxWoiKBwNNE5LbN9mPv9R7/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Y8kFq7Qx354LuqACCyjwuG https://cassyni.com/events/VxWoiKBwNNE5LbN9mPv9R7?videoPreview=1 Art & Morality from Mao Zedong to Xi Jinpingnohttps://cassyni.com/events/VxWoiKBwNNE5LbN9mPv9R7?videoPreview=12022-11-30T12:00:00+00:002647.56Hong Kong Baptist UniversityIn this lecture, Prof. Man reviews the evolution of the agenda of art and literature in China between these two influential leaders. Mao Zedong’s very influential speeches on literature and art at the Yenan Forum in 1942 laid the socialist direction of artistic expression in form and content in the new China. In the Yenan Talks, Mao promoted the important position of literature and art as basic revolutionary causes, and regarded them as the tools and operation of ideological changes and political revolution. In 2014, China leader Xi Jinping gave the “Speech at the Forum on Literature and Art,“ in which he regarded art and literature as important means of enhancing cultural confidence and realizing the China Dream of national rejuvenation with prosperity through a market economy. For Xi, art is regarded as an important manifestation of comprehensive national strength.https://cassyni-user-files-prod.s3.amazonaws.com/Y8kFq7Qx354LuqACCyjwuG https://cassyni.com/slides/outline/YRkpwjRZZezZhXqiK5pn93 https://cassyni.com/events/YRkpwjRZZezZhXqiK5pn93/abstract https://cassyni-user-files-prod.s3.amazonaws.com/V1hUZP3q8aC1o6kU3KY5jL https://cassyni.com/events/YRkpwjRZZezZhXqiK5pn93?videoPreview=1 AI, Creativity and Educationnohttps://cassyni.com/events/YRkpwjRZZezZhXqiK5pn93?videoPreview=12021-12-01T12:00:00+00:004599.72Hong Kong Baptist UniversityCan Artificial Intelligence or AI be creative? AI has been deployed to paint, choreograph, and compose music. If AI can do that, does it make learning or teaching these skills useless? The Academy’s Education-Information Technology unit organised a webinar entitled “AI, Creativity and Education” on Dec 1, 2021. A panel including experts from HKBU and EdUHK explored the current state of AI in performing arts and education, looking specifically at how AI can help artists, teachers, and students in the creative industries.https://cassyni-user-files-prod.s3.amazonaws.com/V1hUZP3q8aC1o6kU3KY5jL https://cassyni.com/slides/outline/R22mFUigynh3wVeokvD9gy https://cassyni.com/events/R22mFUigynh3wVeokvD9gy/abstract https://cassyni-user-files-prod.s3.amazonaws.com/XV7nTf5jxGehaNno2bpJYW https://cassyni.com/events/R22mFUigynh3wVeokvD9gy?videoPreview=1 On Hell w/ Fr. James Dominic Rooneynohttps://cassyni.com/events/R22mFUigynh3wVeokvD9gy?videoPreview=12024-09-21T12:00:00+00:006574.92Hong Kong Baptist UniversityThis seminar presents a metaphysical defense of the possibility of hell, primarily engaging with universalist arguments that deny its existence. The central thesis posits that hell is intrinsically and necessarily possible, grounded in principles of classical theism, particularly the distinction between Creator and creature. Universalist claims, such as those arguing God's intentions preclude eternal damnation, are analyzed and critiqued as question-begging and ultimately dependent on a rejection of classical theism. It is argued that such a rejection would blur the Creator-created distinction, inadvertently leading to problems akin to pantheism or panentheism and exacerbating the problem of evil by implying sin is necessary for divine purposes. A key aspect of the defense involves a reinterpretation of divine providence and human freedom, asserting that God merely *permits* sin and hell; neither is necessary for any good God wishes to achieve. God allows sin not because it is essential for greater goods, but because it does not thwart His ultimate purposes, which include enabling human flourishing up to their own desires. A novel understanding of hell is introduced, suggesting that individuals in hell experience a form of psychological union with the Triune God through the atonement of Christ. Their suffering, described as the "pain of loss," stems from their own failure of self-appreciation (wanting too little for themselves), while objectively, their created personhood remains united with God. This framework maintains eternal suffering without implying punitive divine intention, offering both an objective and subjective "defeat" of evil in hell and reconciling its possibility with divine goodness. The post-mortem fixity of the will is understood as a state where individuals know their desires completely and encounter no reasons to change, thereby persisting in their willed state.https://cassyni-user-files-prod.s3.amazonaws.com/XV7nTf5jxGehaNno2bpJYW https://cassyni.com/slides/outline/8DzDgEir4DrfXr5sPJXUih https://cassyni.com/events/8DzDgEir4DrfXr5sPJXUih/abstract https://cassyni-user-files-prod.s3.amazonaws.com/UcGMZbgXbhNnJeqVndRpi https://cassyni.com/events/8DzDgEir4DrfXr5sPJXUih?videoPreview=1 Politics in Action 2024: Singaporenohttps://cassyni.com/events/8DzDgEir4DrfXr5sPJXUih?videoPreview=12024-05-09T12:00:00+00:001777.12Hong Kong Baptist UniversityOur annual Politics in Action forum features timely analysis of political affairs in six Southeast Asian countries, for an audience of scholars, students and the general public. This flagship forum, now in its 9th year, provides deep insight into the current political context, offering concise yet comprehensive analysis of key political, social, and economic developments in six Southeast Asian nations. In this year's forum, we heard engaging presentations from our country-specialists regarding Indonesia, Laos, Malaysia, Myanmar, Singapore, and Vietnam. Check out our channel for the recordings of the other countries.https://cassyni-user-files-prod.s3.amazonaws.com/UcGMZbgXbhNnJeqVndRpi https://cassyni.com/slides/outline/3HWBDQFbfeKe8kNXNppUzZ https://cassyni.com/events/3HWBDQFbfeKe8kNXNppUzZ/abstract https://cassyni-user-files-prod.s3.amazonaws.com/RQBNYW7fmYy5Apgr3JJhwC https://cassyni.com/events/3HWBDQFbfeKe8kNXNppUzZ?videoPreview=1 Worldwide Teach-In Climate/Justice: Local and Global Perspectives from Hong Kongnohttps://cassyni.com/events/3HWBDQFbfeKe8kNXNppUzZ?videoPreview=12022-03-30T12:00:00+00:005019.4Hong Kong Baptist UniversityIn this one-hour panel, 6 Hong Kong-based artist, academics and educators will discuss the pertinent issues of climate change and justice from both local and global perspectives through their own interests and research areas, ranging from art, service-learning, and environmental humanities to French, European, and African culture and politics. The panelists hope to convey one simple message: climate issues matter to every single global villager.https://cassyni-user-files-prod.s3.amazonaws.com/RQBNYW7fmYy5Apgr3JJhwC https://cassyni.com/events/6GYLBKG5pBd4su8dm9A9FB/seminar/qa https://cassyni.com/slides/outline/6GYLBKG5pBd4su8dm9A9FB https://cassyni.com/events/6GYLBKG5pBd4su8dm9A9FB/abstract https://cassyni-user-files-prod.s3.amazonaws.com/E5YkdhqMEJDNjb5QWJtChU https://cassyni.com/events/6GYLBKG5pBd4su8dm9A9FB?videoPreview=1 Martian Aerodynamics with PyFRnohttps://cassyni.com/events/6GYLBKG5pBd4su8dm9A9FB?videoPreview=12021-05-20T14:00:00+00:002918.96PyFRMartian atmospheric conditions are very different to those on Earth, and present various challenges when designing rotorcraft. Specifically, Mars has a thin atmosphere with lower density compared to Earth. Additionally, the speed of sound on Mars is approximately 72% of that on Earth due to its low surface temperature and atmospheric composition, which puts a limit on rotor speeds in order to avoid high Mach numbers at the blade tip. Taken together, these conditions require Martian rotor blades to operate in a low-Reynolds-number (1,000 to 10,000) compressible flow regime; for which conventional aerofoils have not been designed. Recent studies by Munday et al. and Koning et al. have investigated the performance of aerofoils with flat surfaces and sharp leading edges under Martian atmospheric conditions. These aerofoils induce a higher adverse pressure gradient at their leading edge compared to conventional aerofoils, which can in turn lead to shedding of coherent vortices that do not trigger transition, but mitigate flow separation. In this talk I will present results from our latest GPU-accelerated high-order accurate Direct Numerical Simulations (DNS) of flow over a triangular aerofoil under Martian atmospheric conditions using PyFR, and compare them with results obtained for a triangular aerofoil in the Mars Wind Tunnel at Tohoku University. The importance of span and end-wall effects will be demonstrated. Finally, I will present our latest results from preliminary efforts to optimise a triangular aerofoil for Martian atmospheric conditions using Genetic Algorithms and GPU-accelerated high-order accurate DNS via PyFR.https://cassyni-user-files-prod.s3.amazonaws.com/E5YkdhqMEJDNjb5QWJtChU https://cassyni.com/slides/outline/HdZihZChXA4v58j1K95HjT https://cassyni.com/events/HdZihZChXA4v58j1K95HjT/abstract https://cassyni-user-files-prod.s3.amazonaws.com/HdWnVx3m5yHNc1C2BNTQcN https://cassyni.com/events/HdZihZChXA4v58j1K95HjT?videoPreview=1 New Trends Towards Seismic Metamaterialsnohttps://cassyni.com/events/HdZihZChXA4v58j1K95HjT?videoPreview=12021-06-01T14:00:00+00:006274.44MetaMATWe report on a seismic metamaterial experiment in a pine-tree forest environment where the dense collection of trees behaves as subwavelength coupled resonators for surface seismic waves. For the METAFORET experiment, more than 1000 seismic sensors were deployed over a 120 m × 120 m area to study the properties of the ambient and induced seismic wavefield that propagates in the ground and in trees. The goal of the experiment was to establish a link between seismic-relevant scales and microscale and mesoscale studies that pioneered the development of metamaterial physics in optics and acoustics. The first results of the METAFORET experiment show the presence of frequency band gaps for Rayleigh waves associated with compressional and flexural resonances of the trees, which confirms the strong influence that a dense collection of trees can have on the propagation of seismic waves.https://cassyni-user-files-prod.s3.amazonaws.com/HdWnVx3m5yHNc1C2BNTQcN https://cassyni.com/slides/outline/VympreNpVbumxoxpHVe1sb https://cassyni.com/events/VympreNpVbumxoxpHVe1sb/abstract https://cassyni-user-files-prod.s3.amazonaws.com/8u5RE23oLAVEtERSP6JCEi https://cassyni.com/events/VympreNpVbumxoxpHVe1sb?videoPreview=1 Scattering electromagnetic eigenstates of a two-constituent composite and their exploitation for calculating a physical fieldnohttps://cassyni.com/events/VympreNpVbumxoxpHVe1sb?videoPreview=12021-01-12T14:00:00+00:003384.4MetaMATThe spectral representation of an electric field in a two-constituent composite medium is revisited. A theory is developed for calculating the electromagnetic (EM) eigenstates of Maxwell’s equations for such a composite where the magnetic permeability as well as the electric permittivity have different uniform values in the two constituents. The physical electric field $E(r)$ produced in the system either by a given incident field or by a given source current density is expanded in this set of biorthogonal eigenstates for any position r. If the microstructure consists of a cluster of separate inclusions in a uniform host medium then the EM eigenstates of all the isolated inclusions can also be used to calculate E(r). Once all these eigenstates are known for a given host and a given microstructure then calculation of $E(r)$ only involves performing three-dimensional integrals of known functions and solving sets of linear algebraic equations.https://cassyni-user-files-prod.s3.amazonaws.com/8u5RE23oLAVEtERSP6JCEi https://cassyni.com/slides/outline/L4HiUnqRc63UoRHkfT9X3 https://cassyni.com/events/L4HiUnqRc63UoRHkfT9X3/abstract https://cassyni-user-files-prod.s3.amazonaws.com/9oqhrp6qnqZz9ir4T18eDU https://cassyni.com/slides/outline/6mDZLdRVf16thN89ZFH7RP https://cassyni.com/events/6mDZLdRVf16thN89ZFH7RP/abstract https://cassyni-user-files-prod.s3.amazonaws.com/ArFGcKypvpLeEqfZYsJiy4 https://cassyni.com/events/6mDZLdRVf16thN89ZFH7RP?videoPreview=1 Model Order Reduction and Physics-Based Machine Learning: Challenges, Progress, and Impactnohttps://cassyni.com/events/6mDZLdRVf16thN89ZFH7RP?videoPreview=12021-11-29T15:00:00+00:004108.28Journal of Computational PhysicsWhile machine learning algorithms have been around for a long time, many were developed under different names. Collectively, Projection-based Model Order Reduction (PMOR) methods constitute a case in point. They have been data-driven, physics-informed, machine learning methods since their inception, before these buzzwords became fashionable. For parametric linear problems, they are mature and have already made some impact in industry. For parametric nonlinear problems, their state of the art has been significantly advanced during the last decade on all of theoretical, algorithmic, and application fronts. Furthermore, many rational myth theories about PMOR have been debunked, particularly for highly nonlinear problems. Impressive results have been demonstrated for complex geometries and industrial-grade problems in many applications including nonlinear multi-scale solid mechanics, nonlinear structural dynamics with contact, convection-dominated turbulent flows, wave propagation in both the frequency and time domains, linear and nonlinear multi-disciplinary shape optimization, and uncertainty quantification. On the other hand, high-dimensional parameter spaces, topological changes, and the Kolmogorov n-width issue remain outstanding challenges; nevertheless, significant progress has also been made in these areas. First, this talk will rapidly overview the aforementioned state assessment of PMOR. Next, it will contrast the state of the art of this computational technology with alternative, popular, surrogate modeling techniques including those based on artificial neural networks, before presenting a recently developed, disruptive PMOR approach and reporting on its performance for real-world applications. Then, the talk will discuss the concept of mechanics-informed neural networks for data-driven constitutive modeling, where the informing process is not associated with any physics-based residual or differential equation, but with teaching a neural network mechanics concepts such as objectivity, isotropy (as needed), consistency, material stability, and dynamic stability. Finally, the talk will report on applications pertaining to the recent landing of Perseverance on Mars.https://cassyni-user-files-prod.s3.amazonaws.com/ArFGcKypvpLeEqfZYsJiy4 https://cassyni.com/slides/outline/U16YL2F4XgvCq87KRoVFaD https://cassyni.com/events/U16YL2F4XgvCq87KRoVFaD/abstract https://cassyni-user-files-prod.s3.amazonaws.com/AvJKDMJmn7pCuwm4bTnpwY https://cassyni.com/events/U16YL2F4XgvCq87KRoVFaD?videoPreview=1 Electromechanical Optical Mapping of the Heart and Stomachnohttps://cassyni.com/events/U16YL2F4XgvCq87KRoVFaD?videoPreview=12021-07-13T04:00:00+00:003186.36The Auckland Bioengineering InstituteOptical mapping has long been used to image wave propagation in the heart, almost always in ex vivo, motion-arrested preparations. In the past few years, our laboratory has developed methods to optically map beating hearts--both ex vivo, and very recently, in vivo. Epicardial deformation can be imaged at the same time, enabling study of the bidirectional coupling of electrical and mechanical function. We are extending these methods to the stomach to image slow wave propagation and the resulting contractions.https://cassyni-user-files-prod.s3.amazonaws.com/AvJKDMJmn7pCuwm4bTnpwY https://cassyni.com/slides/outline/YT1r64cSgtgGKkSNqBYebX https://cassyni.com/events/YT1r64cSgtgGKkSNqBYebX/abstract https://cassyni-user-files-prod.s3.amazonaws.com/FHMJBpBMnxt6dQrw1JCuxJ https://cassyni.com/events/YT1r64cSgtgGKkSNqBYebX?videoPreview=1 Broken Symmetries in Acoustic and Mechanical Metamaterialsnohttps://cassyni.com/events/YT1r64cSgtgGKkSNqBYebX?videoPreview=12020-06-30T14:00:00+00:005699.04MetaMATIn this seminar, I will discuss our recent activity in acoustics and mechanics, showing how suitably tailored broken symmetries in meta-atoms and their arrangements open exciting venues for new technology. I will focus in particular on the opportunities offered by time modulation and switching, reciprocal and non-reciprocal Willis coupling, and topological order in metamaterials, which provide unique opportunities for exotic acoustic and mechanical responses. Physical insights into the underlying phenomena, and new devices based on these concepts will be presented.https://cassyni-user-files-prod.s3.amazonaws.com/FHMJBpBMnxt6dQrw1JCuxJ https://cassyni.com/events/5mybUXADaor6yRkMA3WYYM/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Ls54wztC3Ps747TmoNzxkn https://cassyni.com/slides/outline/M68a8yFFzisKvXVCAUHRBB https://cassyni.com/events/M68a8yFFzisKvXVCAUHRBB/abstract https://cassyni-user-files-prod.s3.amazonaws.com/SLDatnRbkFdTNf9zfUpCcW https://cassyni.com/events/M68a8yFFzisKvXVCAUHRBB?videoPreview=1 Nonreciprocal and non-Hermitian material response inspired by semiconductor transistorsnohttps://cassyni.com/events/M68a8yFFzisKvXVCAUHRBB?videoPreview=12022-02-22T14:00:00+00:004316.12MetaMATIn this talk, I will present an overview of the ongoing research work of my group on novel nonreciprocal and non-Hermitian metamaterials that have a bulk electromagnetic response inspired by the operation of a MOSFET transistor. We will show that such metamaterials enable rather exotic physics and can have potential applications in electromagnetic isolation or as wave amplifiers [1]. https://cassyni-user-files-prod.s3.amazonaws.com/SLDatnRbkFdTNf9zfUpCcW https://cassyni.com/slides/outline/4ngPP9sAhtjxJfvM453DjT https://cassyni.com/events/4ngPP9sAhtjxJfvM453DjT/abstract https://cassyni-user-files-prod.s3.amazonaws.com/CgnrvF7DjBwYEkK2bPX48E https://cassyni.com/events/4ngPP9sAhtjxJfvM453DjT?videoPreview=1 Processing of formulaic language in a first and second languagenohttps://cassyni.com/events/4ngPP9sAhtjxJfvM453DjT?videoPreview=12021-05-21T16:00:00+00:003004.92Linguistics and Applied Language StudiesBy looking at the processing of binomials in two groups of bilinguals, L1 Chinese-L2 English and L1 English-L2 Chinese, this study explored cross-language influences in the processing of binomials in both directions, from a first language (L1) to a second language (L2) and from L2 to L1. These findings suggest that L1 influences the processing of L2 binomials, and that there may be some cross-linguistic influence in the opposite direction, i.e., from L2 on L1, although to a lesser extent. Formulaic language, such as collocations (e.g., provide information; red rose), is frequently used by us. For some formulaic sequences, they can be modified and the modified form is also frequently used (e.g., provide some of the information). It has been well documented that more formulaic sequences enjoy a processing advantage over less formulaic ones. However, when it comes to formulaic sequences in their modified form, we are not sure: (1) whether this processing advantage still exists and (2) whether modification degree could affect the processing of formulaic sequences. In this presentation, Shang will report an eye-tracking study and try to answer these two questions from the perspective of Chinese formulaic language reading.https://cassyni-user-files-prod.s3.amazonaws.com/CgnrvF7DjBwYEkK2bPX48E https://cassyni.com/slides/outline/LCQHdNGSQigDVV99LkguK https://cassyni.com/events/LCQHdNGSQigDVV99LkguK/abstract https://cassyni-user-files-prod.s3.amazonaws.com/XgjWH4xkQhs9UA5zW95xe2 https://cassyni.com/events/LCQHdNGSQigDVV99LkguK?videoPreview=1 Mie-resonant metaphotonics and metasurfacesnohttps://cassyni.com/events/LCQHdNGSQigDVV99LkguK?videoPreview=12022-06-07T09:00:00+00:005063.12MetaMATRecently emerged field of Mie-resonant metaphotonics (also called “Mie-tronics”) employs the resonances in high-index dielectric nanoparticles and dielectric metasurfaces aiming for novel applications of subwavelength optics and photonics. High-index subwavelength resonant dielectric structures benefit from low material losses, and they provide a simple way to realize optically induced magnetic response which enables efficient devices outperforming the capabilities of bulk components. Here I plan to discuss the physics of Mie resonances, optical structures employing such resonances, and their link to photonic bound states in the continuum. Also, I aim discussing some applications of these resonances and dielectric metasurfaces.https://cassyni-user-files-prod.s3.amazonaws.com/XgjWH4xkQhs9UA5zW95xe2 https://cassyni.com/slides/outline/AiWtAcfEn7Ex5ExH4UEFmw https://cassyni.com/events/AiWtAcfEn7Ex5ExH4UEFmw/abstract https://cassyni-user-files-prod.s3.amazonaws.com/VYo7v4Ge8NG1GRwmmmprzz https://cassyni.com/events/AiWtAcfEn7Ex5ExH4UEFmw?videoPreview=1 Learn basic NZSL phrasesnohttps://cassyni.com/events/AiWtAcfEn7Ex5ExH4UEFmw?videoPreview=12022-05-24T00:00:00+00:00843.24Deaf Studies Research UnitLearn basic everyday phrases in New Zealand Sign Language with Sara Pivac Alexander, the only Deaf NZSL lecturer at the University. Find out how communicating in NZSL is essential, especially in these mask-wearing times.https://cassyni-user-files-prod.s3.amazonaws.com/VYo7v4Ge8NG1GRwmmmprzz https://cassyni.com/slides/outline/J8GZyVszmLUWiJB9Jv2RpZ https://cassyni.com/events/J8GZyVszmLUWiJB9Jv2RpZ/abstract https://cassyni-user-files-prod.s3.amazonaws.com/6qx5aiDhA6F5PFjpz4oNz2 https://cassyni.com/events/J8GZyVszmLUWiJB9Jv2RpZ?videoPreview=1 Multi-scale human-based cardiac modelling and simulation in hypertrophic cardiomyopathy and post-myocardial infarctionnohttps://cassyni.com/events/J8GZyVszmLUWiJB9Jv2RpZ?videoPreview=12022-07-19T04:00:00+00:004256.24The Auckland Bioengineering InstituteI'll be presenting my recent work on using multi-scale cardiac modelling and simulation to investigate the electrophysiological mechanisms of action of the drug disopyramide on hypertrophic cardiomyopathy patients, as well as the electromechanical disease mechanisms of acute and chronic post-myocardial infarction through linking ECG and LVEF biomarkers. https://cassyni-user-files-prod.s3.amazonaws.com/6qx5aiDhA6F5PFjpz4oNz2 https://cassyni.com/slides/outline/T1raTuynTVfR7BjX2bighB https://cassyni.com/events/T1raTuynTVfR7BjX2bighB/abstract https://cassyni-user-files-prod.s3.amazonaws.com/BzBgdE9oEXJv9anNxkmDdQ https://cassyni.com/events/T1raTuynTVfR7BjX2bighB?videoPreview=1 Global minimizers to the one-phase free boundary problem.nohttps://cassyni.com/events/T1raTuynTVfR7BjX2bighB?videoPreview=12021-11-11T14:00:00+00:003079.84Partial Differential Equations and ApplicationsWe will give a brief overview of the known results on the one-phase Bernoulli free boundary problem, leading to the description of a recent result on the existence of smooth global inhomogeneous minimizing free boundaries. Precisely, given a global 1-homogeneous minimizer $U_0$ to the Alt-Caffarelli energy functional with $sing(F(U_0))=\{0\}$, we provide a foliation of the half-space $\R^{n} \times [0,+\infty)$ with dilations of global inhomogeneous minimizers $\underline U \leq U_0 \leq \bar U$ with analytic free boundaries at distance 1 from the origin. This is a joint work with D. Jerison and H. Shahgholian. https://cassyni-user-files-prod.s3.amazonaws.com/BzBgdE9oEXJv9anNxkmDdQ https://cassyni.com/slides/outline/FewgQC6iMxvRpwkNfcGugH https://cassyni.com/events/FewgQC6iMxvRpwkNfcGugH/abstract https://cassyni-user-files-prod.s3.amazonaws.com/7AooZdHTo4YrMZ8KgcGd3t https://cassyni.com/events/FewgQC6iMxvRpwkNfcGugH?videoPreview=1 From PINNs to DeepOnets: Approximating functions, functionals, and operators using deep neural networksnohttps://cassyni.com/events/FewgQC6iMxvRpwkNfcGugH?videoPreview=12020-10-05T15:00:00+00:003682.16Partial Differential Equations and ApplicationsWe will present a new approach to develop a data-driven, learning-based framework for predicting outcomes of physical and biological systems, governed by PDEs, and for discovering hidden physics from noisy data. We will introduce a deep learning approach based on neural networks (NNs) and generative adversarial networks (GANs). We also introduce new NNs that learn functionals and nonlinear operators from functions and corresponding responses for system identification. Unlike other approaches that rely on big data, here we "learn" from small data by exploiting the information provided by the physical conservation laws, which are used to obtain informative priors or regularize the neural networks. We will also make connections between Gauss Process Regression and NNs and discuss the new powerful concept of meta-learning. We will demonstrate the power of PINNs for several inverse problems in fluid mechanics, solid mechanics and biomedicine including wake flows, shock tube problems, material characterization, brain aneurysms, etc, where traditional methods fail due to lack of boundary and initial conditions or material properties.https://cassyni-user-files-prod.s3.amazonaws.com/7AooZdHTo4YrMZ8KgcGd3t https://cassyni.com/slides/outline/Na3mAPfwujbwUESMKcnHTb https://cassyni.com/events/Na3mAPfwujbwUESMKcnHTb/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Leqv4HwTrw6YhYNEVe7tc6 https://cassyni.com/events/Na3mAPfwujbwUESMKcnHTb?videoPreview=1 The Effects of Hedge Fund Activismnohttps://cassyni.com/events/Na3mAPfwujbwUESMKcnHTb?videoPreview=12021-11-02T22:00:00+00:005549.64SACLIn this paper I explore the relationship between the rise of hedge fund activism and firm outcomes, using a study design that explicitly takes into account how activists pick their targets. Contrary to much prior work, I find no evidence that activism is associated with increased firm operating performance or significant long-term returns once comparing to firms based on their similarity to the targets. However, activism does increase firm payouts to shareholders and decreases investment, consistent with the argument of many critics of activism. I also find that firm-level employment declines significantly following a targeting event, and that the subset of firms that experience an increase in operating performance also engage in higher levels of tax avoidance. The deregulation of proxy access rules, wholesale de-staggering of corporate boards, and the rise in importance of proxy advisory firms who frequently recommend voting for activist proposals have made firms more susceptible to aggressive activism over the past three decades. The results in this paper, coupled with the rhetorical shift in focus from short-term profits to sustainable growth by large institutional investors, suggest a re-framing of the public debate over the benefits of shareholder activism. [Paper for download](https://andrewcbaker.netlify.app/publication/baker_jmp/Baker_JMP.pdf)https://cassyni-user-files-prod.s3.amazonaws.com/Leqv4HwTrw6YhYNEVe7tc6 https://cassyni.com/slides/outline/R3HnPoua72NkZiFUH1w29T https://cassyni.com/events/R3HnPoua72NkZiFUH1w29T/abstract https://cassyni-user-files-prod.s3.amazonaws.com/9tSX3ZtevA2QACi3uLXcZL https://cassyni.com/events/R3HnPoua72NkZiFUH1w29T?videoPreview=1 Machine learning for Fluid Mechanicsnohttps://cassyni.com/events/R3HnPoua72NkZiFUH1w29T?videoPreview=12021-02-03T14:00:00+00:002848.76Department of AeronauticsMany tasks in fluid mechanics, such as design optimization and control, are challenging because fluids are nonlinear and exhibit a large range of scales in both space and time. This range of scales necessitates exceedingly high-dimensional measurements and computational discretization to resolve all relevant features, resulting in vast data sets and time-intensive computations. Indeed, fluid dynamics is one of the original big data fields, and many high-performance computing architectures, experimental measurement techniques, and advanced data processing and visualization algorithms were driven by decades of research in fluid mechanics. Machine learning constitutes a growing set of powerful techniques to extract patterns and build models from this data, complementing the existing theoretical, numerical, and experimental efforts in fluid mechanics. In this talk, we will explore current goals and opportunities for machine learning in fluid mechanics, and we will highlight a number of recent technical advances. Because fluid dynamics is central to transportation, health, and defense systems, we will emphasize the importance of machine learning solutions that are interpretable, explainable, generalizable, and that respect known physics.https://cassyni-user-files-prod.s3.amazonaws.com/9tSX3ZtevA2QACi3uLXcZL https://cassyni.com/slides/outline/8FFEpZujBTYNA4gXuQFMBB https://cassyni.com/events/8FFEpZujBTYNA4gXuQFMBB/abstract https://cassyni-user-files-prod.s3.amazonaws.com/623Co1sdoWTrFejEPpS7Xc https://cassyni.com/events/8FFEpZujBTYNA4gXuQFMBB?videoPreview=1 Dual-Seminar: Erandi Kithulgoda & Vy Doan Lan nohttps://cassyni.com/events/8FFEpZujBTYNA4gXuQFMBB?videoPreview=12021-11-19T03:00:00+00:002907.04Linguistics and Applied Language StudiesErandi and Vy will both present research from their PhD. https://cassyni-user-files-prod.s3.amazonaws.com/623Co1sdoWTrFejEPpS7Xc https://cassyni.com/slides/outline/4nNY8ECRGvYxh7g5wz72ZT https://cassyni.com/events/4nNY8ECRGvYxh7g5wz72ZT/abstract https://cassyni-user-files-prod.s3.amazonaws.com/2vzBFk5c4Q1EoUdnDD3pdC https://cassyni.com/slides/outline/DgNtL62W1VdmHUGKv2VF8Z https://cassyni.com/events/DgNtL62W1VdmHUGKv2VF8Z/abstract https://cassyni-user-files-prod.s3.amazonaws.com/B84XfH1U1oQeLfwqBBUvvJ https://cassyni.com/events/DgNtL62W1VdmHUGKv2VF8Z?videoPreview=1 Experimental observation of the geostrophic turbulence regime of rapidly rotating convectionnohttps://cassyni.com/events/DgNtL62W1VdmHUGKv2VF8Z?videoPreview=12022-05-18T13:00:00+00:002380.4Department of AeronauticsThe competition between turbulent convection and global rotation in planetary and stellar interiors governs the transport of heat and tracers, as well as magnetic-field generation. These objects operate in dynamical regimes ranging from weakly rotating convection to the 'geostrophic turbulence' regime of rapidly rotating convection. However, the latter regime has remained elusive in the laboratory, despite a worldwide effort to design ever-taller rotating convection cells over the last decade. Building on a recent experimental approach where convection is driven radiatively, I will report heat transport measurements in quantitative agreement with this scaling regime, the experimental scaling-law being validated against direct numerical simulations (DNS) of the idealized setup. The scaling exponent from both experiments and DNS agrees well with the geostrophic turbulence prediction. The prefactor of the scaling-law is greater than the one diagnosed in previous idealized numerical studies, pointing to an unexpected sensitivity of the heat transport efficiency to the precise distribution of heat sources and sinks, which greatly varies from planets to stars.https://cassyni-user-files-prod.s3.amazonaws.com/B84XfH1U1oQeLfwqBBUvvJ https://cassyni.com/slides/outline/6GgSkTqWpzFhcbCV9pTgdT https://cassyni.com/events/6GgSkTqWpzFhcbCV9pTgdT/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Mdcbp6oDFSnoJGqDZsiTg https://cassyni.com/events/6GgSkTqWpzFhcbCV9pTgdT?videoPreview=1 Unavoidable patterns in complete simple topological graphsnohttps://cassyni.com/events/6GgSkTqWpzFhcbCV9pTgdT?videoPreview=12022-04-12T19:00:00+00:001850.04Discrete & Computational GeometryNo abstracthttps://cassyni-user-files-prod.s3.amazonaws.com/Mdcbp6oDFSnoJGqDZsiTg https://cassyni.com/slides/outline/8jvTyt592H2ByXg3hWNKMP https://cassyni.com/events/8jvTyt592H2ByXg3hWNKMP/abstract https://cassyni-user-files-prod.s3.amazonaws.com/6WFmKRnbUw63qDDM4HEPWE https://cassyni.com/events/8jvTyt592H2ByXg3hWNKMP?videoPreview=1 Non-linear and non-hydrostatic processes in surf zone waves: new insights from 2D lidar observationsnohttps://cassyni.com/events/8jvTyt592H2ByXg3hWNKMP?videoPreview=12022-04-12T10:40:00+00:001655.08Water WavesIn recent years, remote sensing technology (e.g., lidar or stereo-video imagery) has seen tremendous developments and now allow the collection of accurate and direct measurements of the sea-surface elevation in the nearshore region. In this presentation, we will focus on recent experiments that employed both traditional pressure sensors and 2D lidar scanners to monitor the time-varying free surface elevation associated with breaking and broken waves in the surf zone. In contrast to the traditional ‘single-point’ in-situ instrumentation, lidars directly capture the wave profile and thus provide unprecedented levels of detail on wave transformation processes around breaking in the field. Non-linear and non-hydrostatic effects are found important everywhere in the surf zone: from the outer surf region, where waves initiate breaking, to the inner surf region where they propagate as bores. Yet, traditional methods for the reconstruction of the free surface from pressure measurements in the surf zone either neglect these non-hydrostatic effects or approximate them with linear wave theory. At the wave-by-wave scale, this results in the underestimation of the steepness and wave crest maximal elevations as seen by the pressure sensors. A recently developed non-linear weakly dispersive reconstruction is found to consistently outperform the hydrostatic or classic transfer function reconstructions over the entire surf zone, with relative errors on the surface elevation variance and skewness around 5% on average. The performance of this irrotational method supports the hypothesis that the flow under broken waves is dominated by irrotational motions.https://cassyni-user-files-prod.s3.amazonaws.com/6WFmKRnbUw63qDDM4HEPWE https://cassyni.com/slides/outline/G9eXg8n1c9L2U7CWfPE3mP https://cassyni.com/events/G9eXg8n1c9L2U7CWfPE3mP/abstract https://cassyni-user-files-prod.s3.amazonaws.com/AxhyHysfQCuZcyhLeJCpwY https://cassyni.com/events/G9eXg8n1c9L2U7CWfPE3mP?videoPreview=1 Swyneshed, Aristotle and the Rule of Contradictory Pairsnohttps://cassyni.com/events/G9eXg8n1c9L2U7CWfPE3mP?videoPreview=12021-04-21T10:40:00+00:006470.32Logica UniversalisRoger Swyneshed, in his treatise on insolubles (logical paradoxes), dating from the early 1330s, drew three notorious corollaries from his solution. The third states that there is a contradictory pair of propositions both of which are false. This appears to contradict what Whitaker, in his iconoclastic reading of Aristotle’s De Interpretatione, dubbed “The Rule of Contradictory Pairs” (RCP), which requires that in every such pair, one must be true and the other false. Whitaker argued that, immediately after defining the notion of a contradictory pair, in which one statement affirms what the other denies of the same thing, Aristotle himself gave counterexamples to the rule. This gives some credence to Swyneshed’s claim that his solution to the logical paradoxes is not contrary to Aristotle’s teaching, as many of Swyneshed’s contemporaries claimed. Insolubles are false, he said, because they falsify themselves; and their contradictories are false because they falsely deny that the insoluble itself is false. Swyneshed’s solution depends crucially on the revision he makes to the acount of truth and falsehood, brought out in his first thesis: that a false proposition can signify as it is, or as Paul of Venice, who took up and developed Swyneshed’s solution some sixty years later, puts it, a false proposition can have a true significate. Swyneshed gave a further counterexample to (RCP) when he claimed that some insolubles, like future contingents, are neither true nor false. Dialetheism, the contemporary claim that some propositions are both true and false, is wedded to the Rule, and in consequence divorces denial from the assertion of the contradictory negation. Consequently, Swyneshed’s logical heresy is very different from that found in dialetheism.https://cassyni-user-files-prod.s3.amazonaws.com/AxhyHysfQCuZcyhLeJCpwY https://cassyni.com/slides/outline/CCQT5Qa3Hm3noFSp1wtx9T https://cassyni.com/events/CCQT5Qa3Hm3noFSp1wtx9T/abstract https://cassyni-user-files-prod.s3.amazonaws.com/NqqH8R3r2f6fcANsM4jCSi https://cassyni.com/events/CCQT5Qa3Hm3noFSp1wtx9T?videoPreview=1 The War on the Bulk Heterojunction: A Battle for the Future of Organic Solar Cellsnohttps://cassyni.com/events/CCQT5Qa3Hm3noFSp1wtx9T?videoPreview=12022-06-23T00:15:00+00:003116.76The MacDiarmid Institute for Advanced Materials and NanotechnologyOrganic photovoltaics (OPVs) promise cheap and flexible solar energy. Whereas light generates free charges in silicon photovoltaics, excitons are normally formed in organic semiconductors due to their low dielectric constants, and thus OPVs require molecular heterojunctions to split excitons into charges. This invention of the ‘bulk heterojunction’ has helped progress OPV efficiencies over the last 30 years. However, it has also held the field back from achieving its full potential. The bulk heterojunction adds significant complexity that makes rational device and materials design extremely difficult, and introduces fundamental limits to device efficiencies. In this talk I will summarise our efforts over the last years to overcome the limitations of the bulk heterojunction. I will initially outline our attempts to enhance exciton diffusion length(1), and to make use of the exceptional properties of new small molecule ‘fused ring electron acceptors’(FREAs) (2). Then I will discuss work undertaken in the last two years at VUW that shows a new direction of OPV development is possible, thanks to our discovery(3) of intrinsic free charge photogeneration in the highly efficient molecule known as ‘Y6’. This discovery paves the way for a new type of OPV, based on a ‘doped p-n homojunction’ design, and sets us on a path for reimagining the future of organic electronics. https://cassyni-user-files-prod.s3.amazonaws.com/NqqH8R3r2f6fcANsM4jCSi https://cassyni.com/slides/outline/BDAVDJJmDZo151VAeuX43F https://cassyni.com/events/BDAVDJJmDZo151VAeuX43F/abstract https://cassyni-user-files-prod.s3.amazonaws.com/6MJUY2aAidgyiGSiUXcrSS https://cassyni.com/events/BDAVDJJmDZo151VAeuX43F?videoPreview=1 The powerhouse is overheatingnohttps://cassyni.com/events/BDAVDJJmDZo151VAeuX43F?videoPreview=12022-06-28T04:00:00+00:003872.12The Auckland Bioengineering InstituteATP is Life’s crucial currency. This polyphosphate was selected from its ribose relatives ~4.5 billion years ago to capture and conserve energy and signal and store information and is a neurotransmitter. ATP is formed by substrate level and oxidative phosphorylation (OXP). The first most ancient process is simple and rapid, but low in yield, with noxious waste products. OXP is slower and complicated, and high in yield with innocuous products. OXP is dependent on phospholipids, which support shuttles, redox powered ion pumps, organise turbine-like ATP-synthases, and importantly they partition ions. Clearly, the benefits of OXP were great for complex life forms, as some prehistoric parasites evolved to form mitochondria and chloroplasts, and arguably their high ATP supplies permitted the evolution of large genomes and complex Life. Life’s complexity comes at a cost, an addiction to OXP’s might, and how the mighty can fall. Life on Earth exists because temperatures are neither too hot, nor too cold. For multicellular life these limits are perhaps even more constrained, and possibly more so by mitochondria. Here I will present examples of how mitochondrial OXP is acutely susceptible to temperature in some species, yet remarkably robust in others, and consider what it may all mean in our warming world. https://cassyni-user-files-prod.s3.amazonaws.com/6MJUY2aAidgyiGSiUXcrSS https://cassyni.com/slides/outline/LbWbCv7cxdF15Eehrbw4YV https://cassyni.com/events/LbWbCv7cxdF15Eehrbw4YV/abstract https://cassyni-user-files-prod.s3.amazonaws.com/EUmV6NsHn57RMWNUUm5Qyt https://cassyni.com/events/LbWbCv7cxdF15Eehrbw4YV?videoPreview=1 Importance of Integrated Reporting, Climate Change Reporting & Environmental Management Accountingnohttps://cassyni.com/events/LbWbCv7cxdF15Eehrbw4YV?videoPreview=12022-08-16T23:00:00+00:006059.88SACLThis Seminar will inform participants about the ongoing changes in mandatory reporting requirements for organisations’ social, environmental and economic impacts as well as trends in voluntary reporting of these areas. We will also explore the key role played by management accountants in contributing to corporate social responsibility and its related reporting.https://cassyni-user-files-prod.s3.amazonaws.com/EUmV6NsHn57RMWNUUm5Qyt https://cassyni.com/slides/outline/XTmtDxMAchRUbWUjU9AkVK https://cassyni.com/events/XTmtDxMAchRUbWUjU9AkVK/abstract https://cassyni-user-files-prod.s3.amazonaws.com/4hZnLD3qbmnQfqQz42FicE https://cassyni.com/events/XTmtDxMAchRUbWUjU9AkVK?videoPreview=1 Solving Bin Packing Problems Using VRPSolver Modelsnohttps://cassyni.com/events/XTmtDxMAchRUbWUjU9AkVK?videoPreview=12021-02-11T15:28:33+00:00636.04Operations Research ForumNo abstracthttps://cassyni-user-files-prod.s3.amazonaws.com/4hZnLD3qbmnQfqQz42FicE https://cassyni.com/slides/outline/M6YurQyZ38mE7gwDSzN3eV https://cassyni.com/events/M6YurQyZ38mE7gwDSzN3eV/abstract https://cassyni-user-files-prod.s3.amazonaws.com/UtamYPTkcgmc8xPdrYip5c https://cassyni.com/events/M6YurQyZ38mE7gwDSzN3eV?videoPreview=1 Unravelling the microbiome of wild flowering plants: a comparative study of leaves and flowers in alpine ecosystemsnohttps://cassyni.com/events/M6YurQyZ38mE7gwDSzN3eV?videoPreview=12024-11-12T01:00:00+00:00357.04Microbiome Virtual International ForumBackground: While substantial research has explored rhizosphere and phyllosphere microbiomes, knowledge on flower microbiome, particularly in wild plants remains limited. This study explores into the diversity, abundance, and composition of bacterial and fungal communities on leaves and flowers of wild flowering plants in their natural alpine habitat, considering the influence of environmental factors. Methods: We investigated 50 wild flowering plants representing 22 families across seven locations in Austria. Sampling sites encompassed varied soil types (carbonate/silicate) and altitudes (450–2760 m). Amplicon sequencing to characterize bacterial and fungal communities and quantitative PCR to assess microbial abundance was applied, and the influence of biotic and abiotic factors assessed. Results: Our study revealed distinct bacterial and fungal communities on leaves and flowers, with higher diversity and richness on leaves (228 fungal and 91 bacterial ASVs) than on flowers (163 fungal and 55 bacterial ASVs). In addition, Gammaproteobacteria on flowers and Alphaproteobacteria on leaves suggests niche specialization for plant compartments. Location significantly shaped both community composition and fungal diversity on both plant parts. Notably, soil type influenced community composition but not diversity. Altitude was associated with increased fungal species diversity on leaves and flowers. Furthermore, significant effects of plant family identity emerged within a subset of seven families, impacting bacterial and fungal abundance, fungal Shannon diversity, and bacterial species richness, particularly on flowers. Conclusion: This study provides novel insights into the specific microbiome of wild flowering plants, highlighting adaptations to local environments and plant–microbe coevolution. The observed specificity indicates a potential role in plant health and resilience, which is crucial for predicting how microbiomes respond to changing environments, ultimately aiding in the conservation of natural ecosystems facing climate change pressures.https://cassyni-user-files-prod.s3.amazonaws.com/UtamYPTkcgmc8xPdrYip5c https://cassyni.com/events/7m6qqDY9zVfJSTARcz53iV/abstract https://cassyni-user-files-prod.s3.amazonaws.com/YWmj9rfvbjHSTem8h62YmL https://cassyni.com/slides/outline/YTSBoWLjjJaAWutQ7hdH4q https://cassyni.com/events/YTSBoWLjjJaAWutQ7hdH4q/abstract https://cassyni-user-files-prod.s3.amazonaws.com/WsQ9AsHj1WQnQ9i8bjbjrn https://cassyni.com/events/YTSBoWLjjJaAWutQ7hdH4q?videoPreview=1 Gut metagenomes of Asian octogenarians reveal microbial species promoting healthy agingnohttps://cassyni.com/events/YTSBoWLjjJaAWutQ7hdH4q?videoPreview=12024-10-08T12:00:00+00:00926.0Microbiome Virtual International ForumWhile rapid demographic changes in Asia are driving the incidence of chronic aging-related diseases, the limited availability of high-quality in vivo data hampers our ability to understand complex multi-factorial contributions, including gut microbial, to healthy aging. Leveraging a well-phenotyped cohort of community-living octogenarians in Singapore, we used deep shotgun-metagenomic sequencing for high-resolution taxonomic and functional characterization of their gut microbiomes (n = 234). Joint species-level analysis with other Asian cohorts identified distinct age-associated shifts characterized by reduction in microbial richness, and specific Alistipes and Bacteroides species enrichment (e.g., Alistipes shahii and Bacteroides xylanisolvens). Functional analysis confirmed these changes correspond to metabolic potential expansion in aging towards alternate pathways synthesizing and utilizing amino-acid precursors, vis-à-vis dominant microbial guilds producing butyrate in gut from pyruvate (e.g., Faecalibacterium prausnitzii, Roseburia inulinivorans). Extending these observations to key clinical markers helped identify >10 robust microbial associations to inflammation, cardiometabolic and liver health, including potential probiotic species (e.g., Parabacteroides goldsteinii) and pathobionts (e.g., Klebsiella pneumoniae), highlighting the microbiome’s role as biomarkers and potential targets for promoting healthy aging.https://cassyni-user-files-prod.s3.amazonaws.com/WsQ9AsHj1WQnQ9i8bjbjrn https://cassyni.com/events/Hdz4QzvzZZxpGJB2bf9vCm/abstract https://cassyni-user-files-prod.s3.amazonaws.com/P5zWXNXCdYi2mhHWrHydNn https://cassyni.com/events/VUFvGSkpZxe73NeHJYbQf7/seminar/qa https://cassyni.com/slides/outline/VUFvGSkpZxe73NeHJYbQf7 https://cassyni.com/events/VUFvGSkpZxe73NeHJYbQf7/abstract https://cassyni-user-files-prod.s3.amazonaws.com/E1rHjipnHHcv7cYRhw3yaN https://cassyni.com/events/VUFvGSkpZxe73NeHJYbQf7?videoPreview=1 Presentation of EAJ Issue 15/3 - January 26thnohttps://cassyni.com/events/VUFvGSkpZxe73NeHJYbQf7?videoPreview=12026-01-26T16:00:00+00:002114.6European Actuarial JournalThis seminar presents three distinct studies addressing key challenges in actuarial science and insurance analytics. The first study develops a framework to reconstruct true reported claim counts from observed processed claims distorted by backlogs caused by limited processing capacity. By leveraging total backlog size and stable patterns in reported claims, the approach enables accurate prediction of outstanding claims and facilitates the application of traditional reserving methods. The framework also supports cost optimization balancing processing capacity and backlog expenses, highlighting the impact of capacity constraints on claims data quality and reserving accuracy. The second study investigates mortality differences between Ireland and Northern Ireland from 2000 to 2021 using joint modeling of life tables. Employing generalized additive models (GAM) combined with Kannisto extrapolation for older ages, the analysis reveals shifting mortality patterns across age groups and regions, with Northern Ireland exhibiting higher mortality at younger and middle ages. The study underscores the need for improved national mortality tables and discusses socio-economic and healthcare system factors influencing mortality disparities. The third study surveys recent gradient boosting decision tree (GBDT) algorithms for claim frequency and severity prediction, contrasting point prediction models estimating conditional means with probabilistic models estimating full distributional parameters. The analysis demonstrates that models allowing all distributional parameters to vary with covariates yield superior adequacy compared to those assuming constant parameters except the mean. Empirical comparisons emphasize that no single algorithm universally outperforms others, reflecting the “no free lunch” theorem in machine learning. Collectively, these contributions advance methodologies for claims reserving, mortality modeling, and predictive analytics in actuarial practice.https://cassyni-user-files-prod.s3.amazonaws.com/E1rHjipnHHcv7cYRhw3yaN https://cassyni.com/events/PZnw5qDBERXiUdQmzgGgNR/abstract https://cassyni-user-files-prod.s3.amazonaws.com/N2YNfT2sKQ21icGMKLVE38 https://cassyni.com/slides/outline/AiwDt4PXpX8rGQQJLzJtFF https://cassyni.com/events/AiwDt4PXpX8rGQQJLzJtFF/abstract https://cassyni-user-files-prod.s3.amazonaws.com/EsmXYrw8pmQR9vv7yTqt6r https://cassyni.com/events/AiwDt4PXpX8rGQQJLzJtFF?videoPreview=1 Ethics, Information Security And Legal Considerations For Online Researchnohttps://cassyni.com/events/AiwDt4PXpX8rGQQJLzJtFF?videoPreview=12022-01-19T03:00:00+00:006999.72UKRNNicolas Gold sets the ethical and legal framing using online data more generally. Justin Fidler talks about what the stringent university requirements are and why they are important. Jo Evershed talks about practical steps to help make good choices, navigate university bureaucracy and get online quickly and safely.https://cassyni-user-files-prod.s3.amazonaws.com/EsmXYrw8pmQR9vv7yTqt6r https://cassyni.com/slides/outline/MbE91j8xsxF3w9vjF6V1ph https://cassyni.com/events/MbE91j8xsxF3w9vjF6V1ph/abstract https://cassyni-user-files-prod.s3.amazonaws.com/VA6XBqk5AJRXNjhXxH94AA https://cassyni.com/events/MbE91j8xsxF3w9vjF6V1ph?videoPreview=1 A novel carnivorous diet reduces brain telomere lengthnohttps://cassyni.com/events/MbE91j8xsxF3w9vjF6V1ph?videoPreview=12025-02-20T10:57:29+00:00785.16Royal Society PublishingDevelopmental conditions can profoundly influence adult survival or longevity. One established correlate of longevity is length of telomeres – noncoding DNA regions that protect chromosomal ends. Telomere length in adulthood can be influenced by environmental conditions during development, such as nutrient restriction. Yet, we lack experimental studies of how adult telomere length is affected by a different form of nutritional variation: diet type. Here, we asked how diet type variation during larval development affects telomere length in multiple post-metamorphic somatic tissues of the Mexican spadefoot (Spea multiplicata), an anuran species whose larvae develop on two qualitatively distinct diets: an ancestral omnivorous diet of detritus or a more novel carnivorous diet of live shrimp. We found that larvae developing on the novel shrimp diet developed into post-metamorphic frogs with shorter telomeres in the brain – a structure that is particularly vulnerable to harmful effects of nutritional adversity, such as oxidative stress. Given known links between telomere length and neurological health outcomes, our study suggests that a dietary transition to carnivory might carry costs in terms compromised neural integrity later in life. This work highlights the lasting impact of developmental diet on somatic maintenance and health. https://cassyni-user-files-prod.s3.amazonaws.com/VA6XBqk5AJRXNjhXxH94AA https://cassyni.com/events/XUCDwQ5Tf7KNnfvkkfFNxd/abstract https://cassyni-user-files-prod.s3.amazonaws.com/5qsdKQ7xPJ5C1gUcTqHWVt https://cassyni.com/slides/outline/SXKTskPodUpGh2QPcbaKjB https://cassyni.com/events/SXKTskPodUpGh2QPcbaKjB/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Fj2yAK8nePhVe37qicu9xS https://cassyni.com/events/SXKTskPodUpGh2QPcbaKjB?videoPreview=1 Introduction: Where did the Nagoya Protocol come from?nohttps://cassyni.com/events/SXKTskPodUpGh2QPcbaKjB?videoPreview=12025-05-05T10:00:00+00:00453.48Microbiome Virtual International ForumAt the UN Biodiversity Conference (COP16) in Cali, Colombia in October 2024 new decisions were reached on how benefits can and should be shared from digital sequence information (DSI). The COP16 DSI Decision 16/2 operationalizes a new benefit-sharing mechanism under the Convention on Biological Diversity (CBD) and creates new financial obligations for commercial users of DSI through a sector-based multilateral mechanism called the Cali Fund. The decision also ensures that non-commercial users of DSI can continue to publish in and use sequences in open access databases although DSI databases have new requirements imposed on them. This benefit-sharing approach differs from the bilateral approached under the CBD's Nagoya Protocol. The talk will explain what the DSI decision means for “real-world” scientists, database managers, and users of sequence data. And, in parallel, show what science policy work entails and what is happening on the ground during UN negotiations. https://cassyni-user-files-prod.s3.amazonaws.com/Fj2yAK8nePhVe37qicu9xS https://cassyni.com/slides/outline/8ifSqYtFu3LVMK5PBQeStu https://cassyni.com/events/8ifSqYtFu3LVMK5PBQeStu/abstract https://cassyni-user-files-prod.s3.amazonaws.com/FVo4JWij5LosDXpMhJY2PQ https://cassyni.com/events/8ifSqYtFu3LVMK5PBQeStu?videoPreview=1 Strain displacement in microbiomes via ecological competitionnohttps://cassyni.com/events/8ifSqYtFu3LVMK5PBQeStu?videoPreview=12026-02-10T02:00:00+00:00720.32Microbiome Virtual International ForumMicroorganisms commonly live in diverse communities where changes in composition can be critical for health, industry and the environment. Yet, what enables one strain to competitively replace another in these complex conditions remains poorly understood. Here we develop a mathematical model to determine general principles of strain displacement. Our modelling reveals that weak resource competition enables successful invasion while strong interference competition, for example, via antimicrobial production, enables successful displacement. We verify these predictions using in vitro assays with genetically engineered Escherichia coli. We then apply our principles to displace multidrug-resistant clinical isolates using strains that are equipped with a potent bacteriocin. Finally, we perform experiments with diverse human gut symbionts, which reveal that displacement relies on low resource competition not only between competing strains but also with the broader community, that is, limited nutrient blocking. These general rules for ecological success in microbial communities could be applied for targeted displacement of bacteria.https://cassyni-user-files-prod.s3.amazonaws.com/FVo4JWij5LosDXpMhJY2PQ https://cassyni.com/slides/outline/5HrpboJXoCtp5Wgs5JAQzZ https://cassyni.com/events/5HrpboJXoCtp5Wgs5JAQzZ/abstract https://cassyni-user-files-prod.s3.amazonaws.com/LXKYfPk9SMqDEKisCcUwpS https://cassyni.com/events/5HrpboJXoCtp5Wgs5JAQzZ?videoPreview=1 Hybrid model development for optimization of corrosion inhibitor dosages using LPR measured corrosion rates.nohttps://cassyni.com/events/5HrpboJXoCtp5Wgs5JAQzZ?videoPreview=12025-04-11T14:00:00+00:001755.76Electrochimica ActaA hybrid model was developed using data obtained from a full-scale cooling water cycle of a chemical plant to capture complex interactions between water qualities and added chemicals, so that the model can be used to study corrosion of metals in complex water matrices. The model is based on an adaptation of the Butler-Volmer equation. It relies on easily measurable water qualities, chemical dosages and linear polarization resistance measurements. The current study demonstrates the model’s applicability in the simultaneous optimization of dosages of multiple corrosion inhibitor in real-time. Models developed for dosage optimization in the literature rely on corrosion inhibition efficiencies in simple water matrices determined using electrochemical impedance spectroscopy and potentiodynamic polarization, which cannot be comprehensively applied to complex water matrices containing multiple inhibitors. The current study enables using regular LPR measurements of a cooling water cycle to predict the corrosion rate, potentially optimize dosages of multiple corrosion inhibitors and analyze corrosion mechanisms.https://cassyni-user-files-prod.s3.amazonaws.com/LXKYfPk9SMqDEKisCcUwpS https://cassyni.com/events/Df7sBkqctFx4fFffPvmNg5/abstract https://cassyni-user-files-prod.s3.amazonaws.com/AeiDNUak1J3CwsQ1C58LUW https://cassyni.com/events/FApuXUF2aMy8w2gtarvn8V/abstract https://cassyni-user-files-prod.s3.amazonaws.com/L9MrT24VxF78qWxjeyk4uL https://cassyni.com/slides/outline/QYj3h1ohsebWbK8AFdiPJd https://cassyni.com/events/QYj3h1ohsebWbK8AFdiPJd/abstract https://cassyni-user-files-prod.s3.amazonaws.com/mWiMDupdYTQrkmTNh52yC https://cassyni.com/events/QYj3h1ohsebWbK8AFdiPJd?videoPreview=1 FLOW36: A spectral solver for phase-field based multiphase turbulence simulations on heterogeneous computing architecturesnohttps://cassyni.com/events/QYj3h1ohsebWbK8AFdiPJd?videoPreview=12025-09-01T07:44:14+00:001075.0Computer Physics CommunicationsWe present FLOW36, a GPU-ready solver for interface-resolved simu-lations of multiphase turbulence. The simulation framework relies on the coupling of direct numerical simulation of turbulence, used to describe the flow field, with a phase-field method, used to describe the shape and deformation of a deformable interface and the presence of surfactants. An additional transport equation for a passive scalar can be solved to describe heat transfer in multiphase turbulence. The governing equations are solved in a cuboid domain bounded by two walls along the wall-normal direction where no-slip, free-slip or fixed/moving wall boundary conditions can be applied, while periodicity is applied along the streamwise and spanwise directions. The numerical method relies on a pseudo-spectral approach where Fourier series (periodic directions) and Chebyshev polynomials (wall-normal direc-tion) are used to discretize the governing equations in space. Equations are advanced in time using an implicit-explicit scheme. From the computational viewpoint, FLOW36 relies on a multilevel parallelism. The first level of parallelism relies on the message-passing interface (MPI). A second level of parallelism uses OpenACC directives and cuFFT libraries; this second level is used to accelerate the code execution when heterogeneous computing infrastructures are targeted. In this work, we present the numerical method and we discuss the main implementation strategies, with particular reference to the MPI and OpenACC directives and code portability, performance and maintenance strategies. FLOW36 is released open source under the GPLv3 license.https://cassyni-user-files-prod.s3.amazonaws.com/mWiMDupdYTQrkmTNh52yC https://cassyni.com/slides/outline/2KYrcFh683gNXLeYgpH2Jq https://cassyni.com/events/2KYrcFh683gNXLeYgpH2Jq/abstract https://cassyni-user-files-prod.s3.amazonaws.com/MZy373944rtLwCtgsxLr94 https://cassyni.com/events/2KYrcFh683gNXLeYgpH2Jq?videoPreview=1 Path Integrals from Spacetime Quantum Actionsnohttps://cassyni.com/events/2KYrcFh683gNXLeYgpH2Jq?videoPreview=12025-06-12T07:00:00+00:001323.72Annals of PhysicsThe possibility of extending the canonical formulation of quantum mechanics (QM) to a space–time symmetric form has recently attracted wide interest. In this context, a recent proposal has shown that a spacetime symmetric many-body extension of the Page and Wootters mechanism naturally leads to the so-called Quantum Action (QA) operator, a quantum version of the action of classical mechanics. In this work, we focus on connecting the QA with the well-established Feynman’s Path Integral (PI). In particular, we present a novel formalism which allows one to identify the “sum over histories” with a quantum trace, where the role of the classical action is replaced by the corresponding QA. The trace is defined in the extended Hilbert space resulting from assigning a conventional Hilbert space to each time slice and then taking their tensor product. The formalism opens the way to the application of quantum computation protocols to the evaluation of PIs and general correlation functions, and reveals that different representations of the PI arise from distinct choices of basis in the evaluation of the same trace expression. The Hilbert space embedding of the PIs also discloses a new approach to their continuum time limit. Finally, we discuss how the ensuing canonical-like version of QM inherits many properties from the PI formulation, thus allowing an explicitly covariant treatment of spacetime symmetries.https://cassyni-user-files-prod.s3.amazonaws.com/MZy373944rtLwCtgsxLr94 https://cassyni.com/events/BgahEHHHw9b8GFt1vuv9ky/abstract https://cassyni-user-files-prod.s3.amazonaws.com/29PHWoDe4ca5o6AQTqJfcr https://cassyni.com/slides/outline/JbgmzUrXUvGduYZzavRXYH https://cassyni.com/events/JbgmzUrXUvGduYZzavRXYH/abstract https://cassyni-user-files-prod.s3.amazonaws.com/8mUxhvxkApRoYkerogtoAv https://cassyni.com/events/JbgmzUrXUvGduYZzavRXYH?videoPreview=1 Evolution of Oncology | Next Years and Decade: The Role of Advanced Oncologynohttps://cassyni.com/events/JbgmzUrXUvGduYZzavRXYH?videoPreview=12026-09-11T13:00:00+00:003199.8Advanced OncologyThe next decade will mark a profound transformation in oncology, driven by converging advances in biology, data science, and clinical innovation. In the immediate future (next 3–5 years), oncology will continue its rapid transition toward precision medicine, with growing integration of genomic sequencing, biomarker discovery, and targeted therapies that match “the right drug to the right patient.” Concurrently, cell-based approaches—including CAR-T and T-cell engagers—are expanding across tumor types, contributing to substantial improvements in survival and redefining outcomes even in advanced disease. Looking beyond, oncology will increasingly become a data-driven, AI-enabled discipline. Artificial intelligence is expected to transform drug discovery, optimize clinical trial design, and enable real-time decision support through the integration of multi-omics data (genomics, proteomics, and beyond). Moreover technologies such as gene editing (e.g., CRISPR), liquid biopsies, and advanced imaging will enhance early detection and enable minimally invasive, highly personalized interventions. Over the next decade, oncology is likely to evolve into a holistic and preventive model, emphasizing early detection and equitable access to innovation. However data integration, cost sustainability, and disparities in access to cutting-edge therapies are likely to represent a serious obstacle to achieve these goals. In this evolving landscape, Advanced Oncology can play a pivotal role by serving as a platform for interdisciplinary scholarship disseminating high-impact research to promote precision oncology, immunotherapy, and AI-driven approaches so fostering and integrating the translational interaction among the discipline involved in the battle against cancer.https://cassyni-user-files-prod.s3.amazonaws.com/8mUxhvxkApRoYkerogtoAv https://cassyni.com/events/9DUna1d6kfTGe1UJmuK4RK/abstract https://cassyni-user-files-prod.s3.amazonaws.com/GwYy3MGYjSw1DHL2v8m31g https://cassyni.com/slides/outline/8EJ4wAPbVC3f96kHXYrLfX https://cassyni.com/events/8EJ4wAPbVC3f96kHXYrLfX/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Hhfs6FYM2amQNtFienAaZc https://cassyni.com/events/8EJ4wAPbVC3f96kHXYrLfX?videoPreview=1 Outcomes of Patients Treated With Venetoclax Plus Azacitidine Versus Azacitidine Alone Stratified by Advanced Age and Acute Myeloid Leukemia Composite Modelnohttps://cassyni.com/events/8EJ4wAPbVC3f96kHXYrLfX?videoPreview=12025-09-03T04:00:00+00:00954.12LeukemiaVenetoclax plus azacitidine is recognized as standard of care for patients with acute myeloid leukemia (AML) ineligible for intensive chemotherapy (IC). However, some patients may still not be treated with venetoclax combinations due to frailty concerns. We evaluated efficacy and safety of venetoclax plus azacitidine vs. placebo plus azacitidine in patients with newly diagnosed AML ineligible for IC from the phase 3 VIALE-A study (NCT02993523) and the phase 1b M14-358 study (NCT02203773), stratified by two methods to potentially assess frailty. The first method was age-based (75–79, 80–84, ≥85 years; n = 303 pooled from both studies) and the second was fitness-based using the AML composite model (AML-CM), a comorbidity-based model to estimate mortality risk (Group A, B, C; n = 380, from VIALE-A). Efficacy, including composite complete remission and overall survival, were improved with venetoclax plus azacitidine vs. placebo plus azacitidine across age and AML-CM groups. Safety was generally similar between age and AML-CM groups and no new safety signals were identified. Taken together, these data suggest that patients benefit from venetoclax plus azacitidine regardless of age or degree of frailty and the combination may be considered for patients with AML who may be deemed frail. Clinical trial information NCT02993523; NCT02203773.https://cassyni-user-files-prod.s3.amazonaws.com/Hhfs6FYM2amQNtFienAaZc https://cassyni.com/slides/outline/3Hp2UKvM6cWdk12wX59LwP https://cassyni.com/events/3Hp2UKvM6cWdk12wX59LwP/abstract https://cassyni-user-files-prod.s3.amazonaws.com/M3n5tZcv8yTAybqotM7sPC https://cassyni.com/events/3Hp2UKvM6cWdk12wX59LwP?videoPreview=1 City lizards are more socialnohttps://cassyni.com/events/3Hp2UKvM6cWdk12wX59LwP?videoPreview=12025-09-24T05:05:00+00:00989.48Royal Society PublishingCities are expanding globally, exposing animals to novel ecological conditions that can alter the frequency and nature of their social interactions. Urban habitat features, such as built infrastructure and patchy resource distributions, can constrain movement and promote aggregation, potentially increasing encounters among conspecifics and introducing unique social challenges. Understanding how urbanization affects social behaviour is crucial. However, these effects remain poorly understood, and studies on solitary or non-gregarious species are particularly scarce. Here, we investigate how urbanization influences social behaviour in the Common wall lizard (Podarcis muralis), a territorial species and successful urban dweller. We constructed social networks from proximity-based association data from urban and non-urban lizard populations. Urban lizards had more social connections, stronger associations, and were observed in more associations overall. These differences were not explained by variation in population density. We propose that spatial constraints and resource heterogeneity in urban habitats may enhance social tolerance. Our results reveal that urbanization can reshape social behaviour even in less gregarious species, and suggest that shifts in social strategies may facilitate persistence in urban landscapes.https://cassyni-user-files-prod.s3.amazonaws.com/M3n5tZcv8yTAybqotM7sPC https://cassyni.com/slides/outline/PYRRUyxkVk97GocMJ9QNcd https://cassyni.com/events/PYRRUyxkVk97GocMJ9QNcd/abstract https://cassyni-user-files-prod.s3.amazonaws.com/3aWXrisieixXpQyzbW8gSJ https://cassyni.com/events/PYRRUyxkVk97GocMJ9QNcd?videoPreview=1 Cellular interactions of colloidal nanosilver and role of alginate capping in prevention of soluble Ag+ leachingnohttps://cassyni.com/events/PYRRUyxkVk97GocMJ9QNcd?videoPreview=12025-10-28T09:00:00+00:001365.88Chemical Physics ImpactBiological effects including antimicrobial potencies of nanosilver are well known. Nanosilver particularly, small silver particles having a biopolymer as capping agent have been suggested to be more compatible to cells and biological system. Hypothesis says that a biopolymer, being large in size, could prevent the leaching of Ag+ ions, which are the primary cause of AgNPs toxicity. In order to corroborate this, we synthesized colloidal silver solution which was both reduced and capped by alginate solution and Ag+ ion release kinetics was performed. Overall, it was noted that mechanical agitation aids in the process of ion release which was maximum within first 30 min. (1.8 ± 1 ppm) whereas, only 0.19 ± 0.6 ppm release was observed in non-shaking conditions, in the same duration. After 30 min, the ion release was negligible, irrespective of agitation. Interestingly, the maximum amount of Ag+ ion released was only 5.6 % of total. Further, the colloidal silver was examined for antioxidant activity which was surprisingly higher than the standard ascorbic acid solution. Activity of two key digestive enzymes pepsin and α-amylase was assessed in presence of silver particles in SIF and SSF, respectively. Pepsin was unaffected but α-amylase showed reduced activity with increasing particle concentration (p < 0.05). Next, we examined the biological effects of alginate-capped nanosilver on six bacterial strains that predominantly populate wound sites and a panel of mammalian cells. Response of microbes was both dose- and time-dependent. Among tested, P. mirabilis and K. pneumoniae were able to revive themselves after 24 h. On the other hand, IC50 of the nanosilver on HADSCs, A-431, HaCaT, HEK-293, HeLa, and THP-1 was as low as 13.22, 5.96, 6.289, 12.74, 6.0, 5.6 ppm, respectively. Lastly, through intravenous administration of particles in female BalB/ mice and image analysis, we were able to get an overview of particle safety on mouse organs.https://cassyni-user-files-prod.s3.amazonaws.com/3aWXrisieixXpQyzbW8gSJ https://cassyni.com/events/7F47548KQznsRANV8M5mnV/abstract https://cassyni-user-files-prod.s3.amazonaws.com/GgcvqiizpPUdGxWobZtuzn https://cassyni.com/events/GdNax3RHkhK9Guqd3UZLf7/abstract https://cassyni-user-files-prod.s3.amazonaws.com/7WcSj33CHLX7KtyUwpnWPQ https://cassyni.com/events/L5aLuGmKza5UdZ4XYQ6Duo/abstract https://cassyni-user-files-prod.s3.amazonaws.com/5zehUVTwdQESC8XSQH3Xsc https://cassyni.com/slides/outline/9DLfzs3fjrpduKQTPE1X33 https://cassyni.com/events/9DLfzs3fjrpduKQTPE1X33/abstract https://cassyni-user-files-prod.s3.amazonaws.com/NfrffCDWNaTGVkGw72WjiN https://cassyni.com/events/9DLfzs3fjrpduKQTPE1X33?videoPreview=1 Locomotion on three legs: the tripedal gaits of canine amputeesnohttps://cassyni.com/events/9DLfzs3fjrpduKQTPE1X33?videoPreview=12026-04-14T13:00:00+00:001239.52Royal Society PublishingThe bipedal and quadrupedal gaits of mammals are largely well-characterised, however, with no true, naturally occurring tripedal gaits, locomotion on three legs is not well understood. Understanding tripedalism is valuable for research in both veterinary rehabilitation and robotics, where limb-loss may be encountered. Limb amputation is not uncommon in small animal veterinary medicine, as such, there is a population of domestic tripedal mammals in the form of canine amputees, providing a unique perturbation into the study of locomotion. The aim of this study was to investigate whether 3-legged dogs use distinct limb sequences which could be determined as gaits, with clearly defined kinematics and kinetics. Data were collected from 12 canine amputees (6 forelimb and 6 hindlimb amputees) moving at a range of speeds. At higher speeds, three-legged dogs use a three beat gallop-like gait. Forelimb amputees use a rotary-like gallop, whereas, hindlimb amputees use both rotary- and transverse-like sequences, varying the lead within the forelimb pair. At low speeds two strategies are observed: 1) maintenance of a three-legged gallop with increased stride periods; 2) uncoupled walking, where the intact limb pair ‘walks’ while the single limb moves at a higher frequency, uncoupled from the walking pair. The single limb is constrained by unsupported aerial time, maintaining a consistent period, striking more than once per cycle at lower speeds. Altered force distributions show high peak vertical forces in the single limb of forelimb amputees, but a relatively even distribution across all limbs in hindlimb amputees. https://cassyni-user-files-prod.s3.amazonaws.com/NfrffCDWNaTGVkGw72WjiN https://cassyni.com/slides/outline/K6LP3AW3vNpguK6tBMiKob https://cassyni.com/events/K6LP3AW3vNpguK6tBMiKob/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Jgy5BcqPuVseQ5cAaxRMw4 https://cassyni.com/events/K6LP3AW3vNpguK6tBMiKob?videoPreview=1 Overcoming MEN1-Mediated Resistance With Menin Inhibitor Switching in KMT2A-rearranged AMLnohttps://cassyni.com/events/K6LP3AW3vNpguK6tBMiKob?videoPreview=12026-04-21T14:00:00+00:001069.72LeukemiaMenin inhibitors have generated significant excitement due to their therapeutic potential against difficult-to-treat acute leukemias, and both revumenib and ziftomenib are now approved and in clinical use in the United States. However, resistance mutations, notably MEN1 mutations, can emerge, displacing menin inhibitor binding and leading to clinical resistance. As with other classes of targeted therapies in acute leukemia, effective strategies after the development of resistance mutations represent a major unmet need. A critical question in the field is whether switching between menin inhibitors can circumvent such resistance, analogous to tyrosine kinase inhibitor sequencing in chronic myeloid leukemia. In this Letter, we describe a patient with acute myeloid leukemia who acquired a MEN1 M327I mutation after treatment with the first-in-class menin inhibitor revumenib and subsequently responded to the investigational menin inhibitor bleximenib. This proof-of-concept case highlights the actionable nature of MEN1 resistance mutations and underscores the importance of early mutational profiling to guide therapeutic decision-making. https://cassyni-user-files-prod.s3.amazonaws.com/Jgy5BcqPuVseQ5cAaxRMw4 https://cassyni.com/slides/outline/SW64r3iouc4JDtfpJk1ZMf https://cassyni.com/events/SW64r3iouc4JDtfpJk1ZMf/abstract https://cassyni-user-files-prod.s3.amazonaws.com/TBkiQ6WkgC3RuTLNbzf6wp https://cassyni.com/events/SW64r3iouc4JDtfpJk1ZMf?videoPreview=1 An OpenFOAM based solver for three-phase flow in porous media incorporating foam effectsnohttps://cassyni.com/events/SW64r3iouc4JDtfpJk1ZMf?videoPreview=12026-06-09T17:00:00+00:002002.56Computer Physics CommunicationsFoam injection is a promising alternative for enhanced oil recovery strategies, as it can improve sweep efficiency in gas-assisted processes. Accurately predicting multiphase foam flow in porous media, however, remains challenging, and existing modeling approaches continue to evolve as new foam modeling insights and numerical strategies emerge. In this work, we develop ImpesFOAM, a computational framework for three-phase flow incorporating effects of foam using Finite volume method (FVM) formulation within the OpenFOAM framework and IMplicit-Pressure Explicit-Saturation (IMPES) method. Two foam formulations are incorporated: an implicit-texture model that captures dry-out, oil effects, and surfactant concentration, and a mechanistic population-balance model describing bubble generation and coalescence. Surfactant transport in the aqueous phase is modeled through an additional conservation equation that includes adsorption effects. The object-oriented high-level programming design of OpenFOAM facilitates the link between mathematical modeling and computational implementation, which makes the developed solver more flexible for further foam model implementations. The solver is validated against a comprehensive set of benchmark cases for two and three-phase flow, with and without foam, designed to isolate gravity, capillary pressure, well-driven flow with source and sink terms, and surfactant transport mechanisms. The results show good agreement with analytical, numerical, and experimental results. Moreover, through two three-dimensional field application cases, we demonstrate that foam-assisted Enhanced Oil Recovery (EOR) ultimately yields more economically attractive outcomes, including a substantial increase in oil recovery factor and a decrease in the gas-oil ratio production.https://cassyni-user-files-prod.s3.amazonaws.com/TBkiQ6WkgC3RuTLNbzf6wp https://cassyni.com/slides/outline/2JKTaZ26QAvQ4CuyNxiFwK https://cassyni.com/events/2JKTaZ26QAvQ4CuyNxiFwK/abstract https://cassyni-user-files-prod.s3.amazonaws.com/N58wSa2rtMPjBYyeAqin5U https://cassyni.com/events/2JKTaZ26QAvQ4CuyNxiFwK?videoPreview=1 Chimeric antigen receptor T-cell therapy for the treatment of melanoma: A systematic review of phase one clinical trialsnohttps://cassyni.com/events/2JKTaZ26QAvQ4CuyNxiFwK?videoPreview=12026-05-31T12:00:00+00:001699.64Sage PublishingIntroduction: Melanoma is a growing health concern, with global incidence increasing annually. However, treatment for refractory disease is currently limited. Chimeric antigen receptor (CAR) T-cell therapy has shown promising results in haematological malignancies. Despite this, its utility in solid cancers, such as melanoma, is not yet established. We performed a systematic review of phase one trials to help determine and describe foundational understandings of the safety and efficacy of CAR T-cell therapy for melanoma. Methods: This systematic review was conducted in accordance with the Cochrane Collaboration Handbook for Systematic Review of Interventions and the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) Statement Guidelines. Databases were searched to identify articles before November 18, 2025, which described the use of CAR T-cell therapy in melanoma patients with published results. Study, patient, and treatment characteristics were summarised and analysed. Results: In total, 2726 articles were screened. Ultimately 5 studies comprising 15 patients with melanoma treated with CAR T-cell therapy were analysed and discussed. T-cell therapies were all autologous and the targets for the CAR T-cell therapies included GD2, PD-1 and cMET antigens across a wide variety of cell doses. Across pooled data, clinical responses varied, with some patients displaying either a partial or complete clinical response. Treatment related effects were of grade one or two severity, with no serious adverse effects reported, including neurotoxicity side effects, or treatment limited related toxicity/mortality events. Peak expansion typically occurred within day 7 to 28, but persistence was limited across studies. Conclusion: CAR T-cell therapy for melanoma is a novel treatment approach in its infancy. Results are preliminary, and remain largely descriptive, as findings are limited by heterogeneity and small sample sizes. Further investigation through additional phase one trials, and subsequent phase two/three trials, are required for better establishing direct clinical viability.https://cassyni-user-files-prod.s3.amazonaws.com/N58wSa2rtMPjBYyeAqin5U https://cassyni.com/slides/outline/DfFykuR3u4ahPwjWnc4v4M https://cassyni.com/events/DfFykuR3u4ahPwjWnc4v4M/abstract https://cassyni-user-files-prod.s3.amazonaws.com/CsnpYaSgrwpLfU23KZqyJe https://cassyni.com/events/DfFykuR3u4ahPwjWnc4v4M?videoPreview=1 Inside the Black Box of Big Bang Nucleosynthesis: A Comprehensive Sensitivity Atlas for the Precision Eranohttps://cassyni.com/events/DfFykuR3u4ahPwjWnc4v4M?videoPreview=12026-07-31T15:00:00+00:003432.6Physics ReportsIn this study we present a comprehensive sensitivity atlas for Big Bang Nucleosynthesis (BBN) in which we quantify the dependence of the primordial abundances of helium-4, deuterium, and lithium-7 as well as $N_{\rm{eff}}$ on variations in 14 fundamental particle physics and cosmological parameters and 63 thermonuclear reaction rates. We use the publicly available BBN code $\texttt{PRyMordial}$ to compute each sensitivity using two nuclear reaction rate compilations and two weak-rate normalization schemes, and provide a model independent reference applicable to Beyond the Standard Model (BSM) models in which MeV scale physics is modified. In addition, we rank each parameter's contribution to the theoretical uncertainty budget. We compare our predictions against the latest observational determinations of the primordial abundances, including a recent LBT measurement of the helium-4 abundance [2] which roughly halves the observational uncertainty relative to previous determinations. We present these results both fixing $\Delta N_{\rm eff}$ at its Standard Model (SM) value, and allowing it to be a free parameter using the latest uncertainty from the combined CMB+BAO+BBN 2026 value [3]. When $\Delta N_{\rm eff}$ is allowed to be a free parameter, it dominates the theoretical uncertainty of the helium-4 abundance, highlighting the importance of upcoming observations from the Simons Observatory [4]. As illustrative applications, we examine the deuterium tension and the Lithium Problem in light of our sensitivity analysis. The full set of numerical results and figures is publicly available on GitHub $\texttt{bbn-sensitivity-atlas}$. https://cassyni-user-files-prod.s3.amazonaws.com/CsnpYaSgrwpLfU23KZqyJe https://cassyni.com/slides/outline/BC3ae7hK78jwBUxMXV6iy3 https://cassyni.com/events/BC3ae7hK78jwBUxMXV6iy3/abstract https://cassyni-user-files-prod.s3.amazonaws.com/CDaECeFEoFVEM11NyXia2z https://cassyni.com/events/BC3ae7hK78jwBUxMXV6iy3?videoPreview=1 Aggregate Science - Part 2nohttps://cassyni.com/events/BC3ae7hK78jwBUxMXV6iy3?videoPreview=12026-09-22T08:00:00+00:003527.76Small Structures JournalFor centuries, molecular science has been guided by reductionism, with researchers focusing primarily on the properties of matter at the level of individual molecules. Yet, recent advances in aggregation-induced emission (AIE) research have introduced a transformative paradigm: aggregate science. This emerging field shifts the focus toward collective behaviors and emergent properties arising from interacting molecular systems, offering a more holistic framework for scientific exploration. By moving beyond reductionist constraints, aggregate science unlocks new frontiers of discovery. This seminar series will highlight its far-reaching implications across disciplines — from nanomaterials and optoelectronics to biomedical theranostics and beyond. Through a multidimensional lens, we seek to propel this integrative approach, fostering a paradigm shift in scientific research and revealing deeper insights into complex systems.https://cassyni-user-files-prod.s3.amazonaws.com/CDaECeFEoFVEM11NyXia2z https://cassyni.com/events/MZgtj6oDj7J5rTwtq9z4HB/abstract https://cassyni-user-files-prod.s3.amazonaws.com/WpvSYJsjAxzd77WVtKZR4J https://cassyni.com/events/J8gugwcHokNQuTdAbS74Hs/seminar/qa https://cassyni.com/slides/outline/J8gugwcHokNQuTdAbS74Hs https://cassyni.com/events/J8gugwcHokNQuTdAbS74Hs/abstract https://cassyni-user-files-prod.s3.amazonaws.com/GZdb1nfT5NBZCBaYqBZUc6 https://cassyni.com/events/J8gugwcHokNQuTdAbS74Hs?videoPreview=1 Life in the dark: The microbiomes of mussels from deep-sea hydrothermal ventsnohttps://cassyni.com/events/J8gugwcHokNQuTdAbS74Hs?videoPreview=12025-03-18T13:00:00+00:00791.16Microbiome Virtual International ForumThe manner in which the microbiome is acquired and persists over the lifetime of hosts shapes the ecology and evolution of both beneficial and pathogenic associations. However, our understanding of microbial acquisition and persistence is still rudimentary, particularly in the vast diversity of life that is not genetically tractable, so-called non-model organisms. Bathymodiolus mussels have fascinated biologists since their discovery in the early 1980s at deep-sea hydrothermal vents. These mussels thrive in the deep sea, far away from the photosynthetic primary production at the ocean surface, thanks to their intimate symbiosis with bacteria that provide them with nutrition. In addition to their beneficial symbionts, bathymodioline mussels also host a pathogen, Ca. Endonucleobacter, that infects their nuclei. A single pathogen invades the mussel's nuclei, replicates there, generating up to 80,000 cells and causing the nuclei to swell to 50 times their original size, and eventually escapes when the infected mussel cell bursts. In my talk, I will describe the combined molecular and imaging approaches we are using to gain insights into how the beneficial and pathogenic microbiota of deep-sea mussels enter and persist in their hosts, and how these processes affect the ecology and evolution of these associations. https://cassyni-user-files-prod.s3.amazonaws.com/GZdb1nfT5NBZCBaYqBZUc6