https://cassyni.com/slides/outline/B5fcaaDFGsYFDvXfubNrXf https://cassyni.com/events/B5fcaaDFGsYFDvXfubNrXf/abstract https://cassyni-user-files-prod.s3.amazonaws.com/KXptFn2q3ooXouha6PjHA6 https://cassyni.com/events/B5fcaaDFGsYFDvXfubNrXf?videoPreview=1 Dynamics and mechanism of damage recognition by DNA-repair proteinsnohttps://cassyni.com/events/B5fcaaDFGsYFDvXfubNrXf?videoPreview=12022-12-15T09:00:00+00:004295.0Journal of Biological PhysicsAltered unwinding/bending fluctuations at DNA lesion sites are implicated as plausible mechanisms for damage sensing by DNA-repair proteins. These dynamics are expected to occur on similar timescales as one-dimensional (1D) diffusion of proteins on DNA if effective in stalling these proteins as they scan DNA. We examined the flexibility and dynamics of DNA oligomers containing 3 base pair (bp) mismatched sites specifically recognized in vitro by nucleotide excision repair protein Rad4 (yeast ortholog of mammalian XPC). With laser temperature-jump, we revealed the timescales on which Rad4 unwinds DNA to flip out nucleotides from within damaged sites (1,2). With fluorescence lifetime and correlation spectroscopies, we uncovered significant deviations from canonical B-DNA-like conformations and large-amplitude unwinding dynamics for mismatched constructs specifically recognized by Rad4, even in the absence of Rad4 (3,4). These studies are the first to visualize anomalous unwinding/bending fluctuations in mismatched DNA, on timescales that overlap with the <500 µs “stepping” times of repair proteins on DNA. Such “flexible hinge” dynamics at lesion sites could arrest a diffusing protein to facilitate damage interrogation and recognition. The above studies, like most others on DNA damage recognition mechanisms, were performed with short, torsionally relaxed DNA oligomers that do not reflect DNA topologies in our cells, where the DNA is largely bent and/or supercoiled. Looping and supercoiling are expected to have a profound impact on damage sensing. We have begun studies of DNA dynamics and Rad4 binding in the context of 126-bp DNA minicircles that mimic the bending strain present in nucleosomes. We find that DNA distortions at the 3-bp mismatched site are amplified in these minicircles and that Rad4 binding affinities increase by >100-fold. These studies indicate that much of what we have learned about DNA conformations, dynamics, and damage recognition from studies on short DNA oligomers must be revisited.https://cassyni-user-files-prod.s3.amazonaws.com/KXptFn2q3ooXouha6PjHA6 https://cassyni.com/slides/outline/7dBdV3iM1PWeQWLkYzTYxm https://cassyni.com/events/7dBdV3iM1PWeQWLkYzTYxm/abstract https://cassyni-user-files-prod.s3.amazonaws.com/5is6NnZDB9ZrPGaADujz3Q https://cassyni.com/events/7dBdV3iM1PWeQWLkYzTYxm?videoPreview=1 Face Recognition in the Wild, Deep-learned faces: a surveynohttps://cassyni.com/events/7dBdV3iM1PWeQWLkYzTYxm?videoPreview=12020-11-05T12:30:00+00:003173.08Journal on Image and Video ProcessingNo abstracthttps://cassyni-user-files-prod.s3.amazonaws.com/5is6NnZDB9ZrPGaADujz3Q https://cassyni.com/slides/outline/G2HmcZFvgFhuMiJsJkPPe5 https://cassyni.com/events/G2HmcZFvgFhuMiJsJkPPe5/abstract https://cassyni-user-files-prod.s3.amazonaws.com/YWBD23Q1uy8D2CdXnfPmEE https://cassyni.com/events/G2HmcZFvgFhuMiJsJkPPe5?videoPreview=1 Fusing Big Data and Big Computation in Numerical Weather Predictionnohttps://cassyni.com/events/G2HmcZFvgFhuMiJsJkPPe5?videoPreview=12021-11-03T11:00:00+00:004299.08Data-Centric Engineering JournalAt RIKEN, we have been exploring a fusion of big data and big computation, and now with AI techniques and machine learning (ML). The new Japan’s flagship supercomputer “Fugaku” is designed to be efficient for both double-precision big simulations and reduced-precision ML applications, aiming to play a pivotal role in creating super-smart “Society 5.0.” Our group in RIKEN has been pushing the limits of numerical weather prediction (NWP) through two orders of magnitude bigger computations using the previous Japan’s flagship “K computer”. The efforts include 100-m mesh, 30-second update “Big Data Assimilation” (BDA) fully exploiting the big data from a novel Phased Array Weather Radar. We have achieved the first-ever real-time BDA application with 500-m mesh NWP in the summer of 2020 using a supercomputer Oakforest-PACS of the University of Tokyo and Tsukuba University. In 2021, we used the new Fugaku and performed real-time 30-second update NWP during the periods of Tokyo Olympic and Paralympic games. With Fugaku, we have been exploring ideas for fusing BDA and AI. The data produced by NWP models become bigger and moving around the data to other computers for ML may not be feasible. Having a next-generation computer like Fugaku, good for both big NWP computation and ML, may bring a breakthrough toward creating a new methodology of fusing data-driven (inductive) and process-driven (deductive) approaches in meteorology. This presentation will introduce the most recent results from data assimilation and NWP experiments, followed by perspectives toward a general theory of prediction and control beyond meteorology.https://cassyni-user-files-prod.s3.amazonaws.com/YWBD23Q1uy8D2CdXnfPmEE https://cassyni.com/events/WqbnRv6EqBgtvxXiviuaoX/seminar/qa https://cassyni.com/slides/outline/WqbnRv6EqBgtvxXiviuaoX https://cassyni.com/events/WqbnRv6EqBgtvxXiviuaoX/abstract https://cassyni-user-files-prod.s3.amazonaws.com/2g1HFYULkXw9tYd3wqAcY6 https://cassyni.com/events/WqbnRv6EqBgtvxXiviuaoX?videoPreview=1 Reproducibility of Statistical Hypothesis Testsnohttps://cassyni.com/events/WqbnRv6EqBgtvxXiviuaoX?videoPreview=12023-05-10T15:00:00+00:003905.04Journal of Statistical Theory and PracticeReproducibility is of great importance for scientific research. While many practical issues affecting reproducibility have received much attention in recent years, the reproducibility of statistical inferences has received rather little attention. This talk presents an overview of our recent development of methods to quantify reproducibility of statistical hypothesis tests using nonparametric predictive inference (NPI). Reproducibility is considered to be a predictive problem, with emphasis on the probability that a repeat of a test will lead to the same conclusion as an actual test. After introducing the basics of NPI, its application to reproducibility of basic tests is illustrated for small sample sizes. For larger sample sizes, or more complicated tests, approximate methods for computation are presented. https://cassyni-user-files-prod.s3.amazonaws.com/2g1HFYULkXw9tYd3wqAcY6 https://cassyni.com/events/RQU8vPyU19bpY6HVKounp5/seminar/qa https://cassyni.com/slides/outline/RQU8vPyU19bpY6HVKounp5 https://cassyni.com/events/RQU8vPyU19bpY6HVKounp5/abstract https://cassyni-user-files-prod.s3.amazonaws.com/LxRGb8J3kh7SHtyRyqhHPc https://cassyni.com/events/RQU8vPyU19bpY6HVKounp5?videoPreview=1 Data-driven complex dynamicsnohttps://cassyni.com/events/RQU8vPyU19bpY6HVKounp5?videoPreview=12023-05-03T14:00:00+00:002305.44Nonlinear Dynamics, an International Journal of Nonlinear Dynamics and Chaos in Engineering SystemsWith the availability of extensive data from simulations and laboratory and field experiments, data-driven dynamics is playing a key role in understanding the behavior of complex systems. Different examples ranging from rogue waves in the ocean to unmanned air vehicles will be used to illustrate how data can be used to build models to predict as well as forecast complex dynamics.https://cassyni-user-files-prod.s3.amazonaws.com/LxRGb8J3kh7SHtyRyqhHPc https://cassyni.com/events/Ab21XtZiqQzCE9znKA64GM/seminar/qa https://cassyni.com/slides/outline/Ab21XtZiqQzCE9znKA64GM https://cassyni.com/events/Ab21XtZiqQzCE9znKA64GM/abstract https://cassyni-user-files-prod.s3.amazonaws.com/KhXxHZZATUjSQvT6VUR7MG https://cassyni.com/events/Ab21XtZiqQzCE9znKA64GM?videoPreview=1 Nektar++ updates and future developmentsnohttps://cassyni.com/events/Ab21XtZiqQzCE9znKA64GM?videoPreview=12023-06-13T12:00:00+00:006894.16NEKTAR++No abstracthttps://cassyni-user-files-prod.s3.amazonaws.com/KhXxHZZATUjSQvT6VUR7MG https://cassyni.com/slides/outline/MTJvfZK9tr6PtuXDDGGBqo https://cassyni.com/events/MTJvfZK9tr6PtuXDDGGBqo/abstract https://cassyni-user-files-prod.s3.amazonaws.com/AicTtQFLDHif6piRW3nwp https://cassyni.com/events/MTJvfZK9tr6PtuXDDGGBqo?videoPreview=1 ORCID & Humanities and Social Sciencesnohttps://cassyni.com/events/MTJvfZK9tr6PtuXDDGGBqo?videoPreview=12022-11-01T14:00:00+00:003584.8ORCIDHear from Humanities and Social Science researchers about their experiences using ORCID. We will also share best practices and tips for maintaining an ORCID record specific to the Humanities and Social Sciences.https://cassyni-user-files-prod.s3.amazonaws.com/AicTtQFLDHif6piRW3nwp https://cassyni.com/slides/outline/PRsijfPNFKP4SP1Fxr3rPX https://cassyni.com/events/PRsijfPNFKP4SP1Fxr3rPX/abstract https://cassyni-user-files-prod.s3.amazonaws.com/JwFGyd9RDrsPAbUsuyP4SS https://cassyni.com/events/PRsijfPNFKP4SP1Fxr3rPX?videoPreview=1 Machine Learning for Fluid Dynamics: Models and Controlnohttps://cassyni.com/events/PRsijfPNFKP4SP1Fxr3rPX?videoPreview=12020-12-04T12:00:00+00:001947.72Brunton LabThis video discusses how machine learning is currently being used to model and control fluid dynamics.https://cassyni-user-files-prod.s3.amazonaws.com/JwFGyd9RDrsPAbUsuyP4SS https://cassyni.com/events/XLH1bEFeg1AikRXEiq2Yyj/seminar/qa https://cassyni.com/slides/outline/XLH1bEFeg1AikRXEiq2Yyj https://cassyni.com/events/XLH1bEFeg1AikRXEiq2Yyj/abstract https://cassyni-user-files-prod.s3.amazonaws.com/D72PBdDWtvSM2dcPQJjwTc https://cassyni.com/events/XLH1bEFeg1AikRXEiq2Yyj?videoPreview=1 The power of peer networking for improving STEM faculty job applications: a successful pilot programmenohttps://cassyni.com/events/XLH1bEFeg1AikRXEiq2Yyj?videoPreview=12023-07-18T14:00:00+00:003716.36Royal Society PublishingTo attain a faculty position, postdoctoral fellows submit job applications that require considerable time and effort to produce. Although mentors and colleagues review these applications, postdocs rarely receive iterative feedback from reviewers with the breadth of expertise typically found on an academic search committee. To address this gap, we describe an international peer-reviewing programme for postdocs across disciplines to receive reciprocal, iterative feedback on faculty applications. A participant survey revealed that nearly all participants would recommend the programme to others. Furthermore, our programme was more likely to attract postdocs who struggled to find mentoring, possibly because of their identity as a woman or member of an underrepresented population in STEM or because they changed fields. Between 2018 and 2021, our programme provided nearly 150 early career academics with a diverse and supportive community of peer mentors during the difficult search for a faculty position and continues to do so today. As the transition from postdoc to faculty represents the largest ‘leak’ in the academic pipeline, implementation of similar programmes by universities or professional societies would provide psycho-social support necessary to prevent attrition of individuals from underrepresented populations as well as increase the chances of success for early career academics in their search for independence.https://cassyni-user-files-prod.s3.amazonaws.com/D72PBdDWtvSM2dcPQJjwTc https://cassyni.com/slides/outline/KyLVQsrhB7WRQghhKBftrh https://cassyni.com/events/KyLVQsrhB7WRQghhKBftrh/abstract https://cassyni-user-files-prod.s3.amazonaws.com/RE1XG1NQZxFvEzRpFtwfEv https://cassyni.com/events/KyLVQsrhB7WRQghhKBftrh?videoPreview=1 Model Based Reinforcement Learning: Policy Iteration, Value Iteration, and Dynamic Programmingnohttps://cassyni.com/events/KyLVQsrhB7WRQghhKBftrh?videoPreview=12022-01-07T12:00:00+00:001629.32Brunton LabHere we introduce dynamic programming, which is a cornerstone of model-based reinforcement learning. We demonstrate dynamic programming for policy iteration and value iteration, leading to the quality function and Q-learning.https://cassyni-user-files-prod.s3.amazonaws.com/RE1XG1NQZxFvEzRpFtwfEv https://cassyni.com/events/ChXeuGkViTvNQXeQ2cVPj/abstract https://cassyni-user-files-prod.s3.amazonaws.com/2f5jUmU6TdNB4iEqn8YCPp https://cassyni.com/events/3fwYtKWNh1EQjM1CwiX87f/seminar/qa https://cassyni.com/slides/outline/3fwYtKWNh1EQjM1CwiX87f https://cassyni.com/events/3fwYtKWNh1EQjM1CwiX87f/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Ee2cmP2fKsCjCrUzfT3zrJ https://cassyni.com/events/3fwYtKWNh1EQjM1CwiX87f?videoPreview=1 Chronicles from a distressed asteroidnohttps://cassyni.com/events/3fwYtKWNh1EQjM1CwiX87f?videoPreview=12023-03-29T13:00:00+00:003496.32Department of AeronauticsThis seminar will provide an overview on LICIACube Mission, and on how it made history facing the challenges of a voyage through interplanetary space.https://cassyni-user-files-prod.s3.amazonaws.com/Ee2cmP2fKsCjCrUzfT3zrJ https://cassyni.com/slides/outline/976pWU92vQFagT3dA1bByw https://cassyni.com/events/976pWU92vQFagT3dA1bByw/abstract https://cassyni-user-files-prod.s3.amazonaws.com/HpUpjUzYT5vyMCL8NdMEJr https://cassyni.com/events/976pWU92vQFagT3dA1bByw?videoPreview=1 Research Discovery & Organization - Part 2nohttps://cassyni.com/events/976pWU92vQFagT3dA1bByw?videoPreview=12023-07-11T18:30:00+00:003158.6SCIWRITER### Next Steps Like the [course?](https://www.sciwriter.ai/ai-tools-for-research) Please share with your academic community. Want to share your experiences and hear what others think of the tools learned in the course? Join our ['experience share' WhatsApp community](https://chat.whatsapp.com/I0EpkIyPZti6bZ4PgAztwz) Link to Nature [article](https://www.nature.com/articles/d41586-023-02218-z) Get updates on [Twitter](https://twitter.com/SciWriterAI) https://cassyni-user-files-prod.s3.amazonaws.com/HpUpjUzYT5vyMCL8NdMEJr https://cassyni.com/events/GWptCiquWGZ6SVEXiBCpS1/seminar/qa https://cassyni.com/slides/outline/GWptCiquWGZ6SVEXiBCpS1 https://cassyni.com/events/GWptCiquWGZ6SVEXiBCpS1/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Dt2SmwVAYiREbyccTb3UNa https://cassyni.com/events/GWptCiquWGZ6SVEXiBCpS1?videoPreview=1 Session 11nohttps://cassyni.com/events/GWptCiquWGZ6SVEXiBCpS1?videoPreview=12023-07-05T03:15:00+00:002553.28New Phytologist Foundation Marine environments are responsible for 50% of the net primary fixation of carbon globally. Predominantly, the Calvin Benson Basham cycle fixes carbon with the initial enzyme being Rubisco. Rubisco has been shown to be a significant bottleneck in photosynthesis, due to a slow catalytic rate and promiscuity of the enzyme. Previous Rubisco studies have largely focused on land plants, and little is known about the diversity and abundance of Rubisco within marine environments. Through analysing publicly available metagenomes and metatranscriptomes from the Earth’s seas and oceans; we have begun to paint a picture of the global abundance and variation of Rubisco. On top of this, sequence analysis of Rubisco structures provides evidence for adaption of the large and small subunit to differing environments, highlighting residues that diverge in tropical and polar systems. This study expands our knowledge of the Rubisco sequence space and presents opportunities for future engineering projects in economically important plants. Mangroves are one of the most threatened ecosystems in the world. Understanding the drivers and limitations of gene flow, phylogeography and genetic adaptation is crucial to effectively manage the threats and conserve the long-term evolutionary potential of mangroves. The first part of this talk summarizes key research findings on the biogeography of major mangrove tree species in Southeast Asia and the greater Indo-West Pacific region. In essence, propagule dispersal capabilities, land barriers and ocean currents are drivers of gene flow and underscores the importance of long-distance dispersal in connecting fragmented mangrove populations. The second part of the talk describes our work on abiotic stress response in mangroves, especially at the species range limits. Current understanding of the molecular mechanism underlying stress adaptation points toward diverging strategies in stress response, even among closely related species. These studies will be important in estimating the adaptive potential of mangroves under climate change. The third part of this talk focuses on recent pstudies on the application of environmental DNA (eDNA) as an effective biomonitoring tool in mangroves. Our findings demonstrated the dynamic distribution of fish species, the transient nature of eDNA in tropical waters, and the importance of bioregionalization in designing global studies.https://cassyni-user-files-prod.s3.amazonaws.com/Dt2SmwVAYiREbyccTb3UNa https://cassyni.com/events/JVSvW5wtfThagyo1KYcXiM/seminar/qa https://cassyni.com/slides/outline/JVSvW5wtfThagyo1KYcXiM https://cassyni.com/events/JVSvW5wtfThagyo1KYcXiM/abstract https://cassyni-user-files-prod.s3.amazonaws.com/HJ1kdCaDUefMPZam6EY6f8 https://cassyni.com/events/JVSvW5wtfThagyo1KYcXiM?videoPreview=1 Swimming cells: a dance of geometry and motionnohttps://cassyni.com/events/JVSvW5wtfThagyo1KYcXiM?videoPreview=12023-08-24T14:00:00+00:006184.32Journal of Biological PhysicsIn recent years, biological motile cells like bacteria and microalgae have attracted enormous interest in the physics community because they establish the most significant example of nonequilibrium systems. Understanding their motion has immense biological and ecological implications. When the motion of a microscopic organism is observed closely, it appears erratic, and yet the combination of nonequilibrium forces and surfaces can produce striking examples of organization in microbial systems. Combining experiments, analytical and numerical calculations [1,2] we demonstrate that intricate patterns can be observed from the level of a single cell exploring an isolated habitat to an entire colony. In the first part of this talk, we will discuss the influence of boundaries on the motion of a single Chlamydomonas cell. We theoretically predict a universal relation between probability fluxes and global geometric properties that is directly confirmed by experiments [2]. Our results represent a general description of the structure of such nonequilibrium fluxes down at the single cell level. This might open the possibility of designing devices that are able to guide the motion of such microbial cells. In the second part of this talk, we investigate the motility and collective organization of colonies of filamentous cyanobacteria [3]. As their density increases, filaments gliding on a substrate show a transition from an isotropic distribution to bundles arranged in a reticulate pattern. Based on our experimental observations, we introduce a model accounting for the filaments’ large aspect ratio, fluctuations in curvature, motility, and nematic interactions. This minimal model of active filaments recapitulates the observations, and rationalizes the appearance of a characteristic lengthscale in the system, based on the Péclet number of the cyanobacteria filaments.https://cassyni-user-files-prod.s3.amazonaws.com/HJ1kdCaDUefMPZam6EY6f8 https://cassyni.com/slides/outline/Jz6XYmbR6vFdgkKtuyuKyf https://cassyni.com/events/Jz6XYmbR6vFdgkKtuyuKyf/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Dcc768jfmxBXjXPaUxQgNz https://cassyni.com/events/Jz6XYmbR6vFdgkKtuyuKyf?videoPreview=1 The status of science in the age of advanced automationnohttps://cassyni.com/events/Jz6XYmbR6vFdgkKtuyuKyf?videoPreview=12023-02-20T17:00:00+00:003486.36DeSci FoundationAs human abilities to automate mathematical work, text generation, and image creation achieve heightened progress, once-speculative questions regarding the wholesale automation of scientific disciplines, and adaptation thereto, become pragmatic. Such questions prompt organizations that produce knowledge goods to develop strategies for research, curation, and distribution that avoid predictable obsolescence, sustain trust, and deploy new practices of human cognitive labor that create novel value in excess of that deliverable by machine-driven science. In his talk, James Douglas Boyd will discuss strategies for navigating a new economic regime in the sciences; thoughts on the future role of pure research in an increasingly technological society; and implications for the 'decentralized science' (DeSci) movement.https://cassyni-user-files-prod.s3.amazonaws.com/Dcc768jfmxBXjXPaUxQgNz https://cassyni.com/slides/outline/RuAzCLemFL1RBZKUHRUG8M https://cassyni.com/events/RuAzCLemFL1RBZKUHRUG8M/abstract https://cassyni-user-files-prod.s3.amazonaws.com/JNrG5sLMPxAz99AXQA6mpJ https://cassyni.com/events/RuAzCLemFL1RBZKUHRUG8M?videoPreview=1 Functional Hardware Design and Verification Revisitednohttps://cassyni.com/events/RuAzCLemFL1RBZKUHRUG8M?videoPreview=12023-09-12T11:00:00+00:001895.6HiPEDS CentreI have long been fascinated by the problem of how to describe and reason about regular algorithms, and especially those that are well suited to direct implementation as circuits. I use higher order functions to capture circuit structure, and I argue for the use of correctness preserving transformations. An important class of transformations enables trade-offs between space and time. I keep coming back to the problem of folding circuits or indeed programs so that they fit into less space or onto a given architecture. This problem seems to crop up all over the place, for example when colleagues at DeepMind fold huge programs implementing language models onto available hardware, or in Carl Seger's Thor system for hardware design by transformation, presented at NANDA last year. So I think it is time to tackle these transformations, and programming language support for them, again, since I am not satisfied with my earlier attempts. In this talk, I will concentrate on circuits, and will present first steps towards verified circuit folding. A key aim is to design transformations that allow as much as possible of the resulting verification to be done using combinational rather than sequential verification.https://cassyni-user-files-prod.s3.amazonaws.com/JNrG5sLMPxAz99AXQA6mpJ https://cassyni.com/events/9bn3fnJSmDjQWDcyuxKVPK/abstract https://cassyni-user-files-prod.s3.amazonaws.com/G5shVbikCoujniab8kv8FY https://cassyni.com/events/QRFoAvE5LKGUuK2kiZjHt1/seminar/qa https://cassyni.com/slides/outline/QRFoAvE5LKGUuK2kiZjHt1 https://cassyni.com/events/QRFoAvE5LKGUuK2kiZjHt1/abstract https://cassyni-user-files-prod.s3.amazonaws.com/R3ptkoyDu3ZghL5Dk2DrJJ https://cassyni.com/events/QRFoAvE5LKGUuK2kiZjHt1?videoPreview=1 Interacting Active Matter: beyond two-dimensionsnohttps://cassyni.com/events/QRFoAvE5LKGUuK2kiZjHt1?videoPreview=12023-10-26T14:00:00+00:003487.8Journal of Biological PhysicsI will discuss mechanics of how cells use finger-like protrusions known to interact with their surrounding medium. First, I will present experimental and theoretical results of active mirror-symmetry breaking in subcellular skeleton of filopodia that allows for rotation, helicity, and buckling of these cellular fingers in a wide variety of cells ranging from epithelial, mesenchymal, cancerous and stem cells. I will then describe in-vivo experiments together with theoretical modeling showing how during frog embryo development specialized active cells interact with an active epithelium. In particular, I will discuss how specialized cells probe and modify an epithelial layer, and how they insert themselves and integrate within the epithelium. Finally, I will describe new computational results on the fluid-to-glass transition in 3D cell layers.https://cassyni-user-files-prod.s3.amazonaws.com/R3ptkoyDu3ZghL5Dk2DrJJ https://cassyni.com/events/VrR4o4rjZiHerR5AvroMkH/seminar/qa https://cassyni.com/slides/outline/VrR4o4rjZiHerR5AvroMkH https://cassyni.com/events/VrR4o4rjZiHerR5AvroMkH/abstract https://cassyni-user-files-prod.s3.amazonaws.com/AakrAf4Q4koe9thzpkFu8z https://cassyni.com/events/VrR4o4rjZiHerR5AvroMkH?videoPreview=1 Valorization of surface-water RO brines via Assisted-Reverse Electrodialysis for minerals recoverynohttps://cassyni.com/events/VrR4o4rjZiHerR5AvroMkH?videoPreview=12024-03-12T10:00:00+00:004109.04ElsevierSurface waters, though often highly impacted by high turbidity, microbial content, Natural Organic Matter (NOM) and the presence of microcontaminants, such as pesticides and pharmaceuticals, are frequently used as resource for drinking water production. Application of Low-pressure Reverse Osmosis (LPRO) shows to be promising for surface water treatment due to its combined performances of water softening and removal of dissolved organic matter (DOM) and micropollutants but requires a remineralization step of the permeate to ensure water equilibrium prior to distribution. A novel solution for remineralization of LPRO permeate by salt recovery from LPRO brine was investigated through application of Assisted-Reverse Electrodialysis (ARED) to these two streams in parallel. In contrast to the recovery of energy in RED technology, an electric field is applied in ARED to enhance the spontaneous flux of ions from the concentrate to the dilute solution. The proof of concept of this novel approach was first validated through extensive lab-work and followed by a pilot-scale demonstration to assess the possibility of selectively recovering minerals from the brine (i.e. mainly calcium and bicarbonates) while quantitatively retaining micropollutants and keeping the passage of NOM under control. The data obtained throughout the research program further allowed to develop and calibrate a process-specific model, which was further used to evaluate the total costs of this new application at industrial scale. Pilot-testing showed the process was able to increase LPRO permeate mineral content from 6 mg/L CaCO3 up to values of 1060 mg/L CaCO3 and from 26 µS/cm up to 1906 µS/cm for hardness and conductivity, respectively. The significant recovery of minerals, resulting in a remineralized permeate hardness well above the final target value of 90 mg/L CaCO3, is a very positive result for industrial application of the system (where the treated permeated could be blended with a large stream of by-passed RO feedwater), as only a small footprint unit applied to a fraction of the permeate would be required for full remineralization. This small footprint is a significant advantage in the techno-economic evaluation of the process, when compared to traditional remineralization units (e.g. limestone media contact filtration). To ensure that the process is viable for industrial application, its ability to preserve the permeate’s integrity with respect to various contaminants such as pesticides is critical. Pilot testing provided microcontaminant breakthrough data for 32 compounds which highlighted low levels of micropollutant passage with an overall retention of 91%, while natural organic matter (NOM) breakthrough ranged from 12% to 25% with a limited impact on bacterial regrowth as measured by Assimilable Organic Carbon (AOC). https://cassyni-user-files-prod.s3.amazonaws.com/AakrAf4Q4koe9thzpkFu8z https://cassyni.com/slides/outline/BaLqjtNf7h253PXBhhVphs https://cassyni.com/events/BaLqjtNf7h253PXBhhVphs/abstract https://cassyni-user-files-prod.s3.amazonaws.com/AWiPPL3Sf4weo22AknX8Vk https://cassyni.com/events/BaLqjtNf7h253PXBhhVphs?videoPreview=1 A Brief Survey on the Burns-Krantz Rigiditynohttps://cassyni.com/events/BaLqjtNf7h253PXBhhVphs?videoPreview=12023-08-16T15:00:00+00:003331.28 Journal of Geometric Analysis & Complex Analysis and its SynergiesIn 1994, Burns and Krantz proved some fundamental boundary rigidity theorems, which have been generalized in various settings in the last three decades. In this talk, we will give a brief survey on such rigidity results, including our own recent contribution to this subject.https://cassyni-user-files-prod.s3.amazonaws.com/AWiPPL3Sf4weo22AknX8Vk https://cassyni.com/events/87tUkzPeFZvF3fntYmQh3s/seminar/qa https://cassyni.com/slides/outline/87tUkzPeFZvF3fntYmQh3s https://cassyni.com/events/87tUkzPeFZvF3fntYmQh3s/abstract https://cassyni-user-files-prod.s3.amazonaws.com/6azuCywNwhY4zDbq2hhdmx https://cassyni.com/events/87tUkzPeFZvF3fntYmQh3s?videoPreview=1 The Power of Retrieval for Video Analysis on Human Behavior Understandingnohttps://cassyni.com/events/87tUkzPeFZvF3fntYmQh3s?videoPreview=12024-03-07T11:30:00+00:003026.04Journal on Image and Video ProcessingIn this talk, Dr. Liu will introduce an industrial level framework of utilizing the power of retrieval techniques for video analysis on human behavior sensing and understanding. This talk will mainly demonstrate a series of selected research achievements that contributed to both academia and industry in our framework. Our framework is composed of a series of cutting-edge technologies that sense the data generated in the real world, transform them into readable, visible, and modellable digital forms, and finally analyze these digital data to understand the human behavior. For example, such cutting-edge technologies include the human sensing by traditional cameras [MM’14, MM’16], 360 cameras [MM’19, WACV’20, ICIP’21], and microwave sensors [MM’20], the action recognition [MM’19, WACV’20, MM’20, ICIP’21], the object tracking [MIPR’19, BigMM’19], the human object interaction [CBMI’19], the scene recognition [MM’19], the behavioral pattern analysis [MM’16, ICMR’18 MIPR’19], the retrieval [MM’14, MM’16, MM’17, ICMR’18, CBMI’19, ICASSP’21] and the visualization [SIGGRAPH’16, ICMR’18], towards the fully understanding of human behavior. These works will be introduced in the way of a general overview with interactive technical demos and interesting insights, for human behavior sensing and understanding by adopting effective processing techniques and designing efficient algorithms. Finally, Dr. Liu will pick up and share some challenging issues and directions for the realization of digital society in the future.https://cassyni-user-files-prod.s3.amazonaws.com/6azuCywNwhY4zDbq2hhdmx https://cassyni.com/events/A6Utwiyk1Q919P57ujGdUR/seminar/qa https://cassyni.com/slides/outline/A6Utwiyk1Q919P57ujGdUR https://cassyni.com/events/A6Utwiyk1Q919P57ujGdUR/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Jz6JKzCtZABERFFytCRGn2 https://cassyni.com/events/A6Utwiyk1Q919P57ujGdUR?videoPreview=1 Turbulent-laminar patternsnohttps://cassyni.com/events/A6Utwiyk1Q919P57ujGdUR?videoPreview=12024-02-02T16:00:00+00:003769.16Journal of Fluid MechanicsExperiments and numerical simulations have shown that turbulence in transitional wall-bounded shear flows such as plane Couette and Poiseuille flow frequently takes the form of long oblique bands, if the domains are sufficiently large to accommodate them. At their upper Reynolds-number threshold, laminar regions carve out gaps in otherwise uniform turbulence, thereby forming regular oblique turbulent-laminar patterns with a large spatial wavelength. At the lower threshold, isolated turbulent bands sparsely populate otherwise laminar domains and complete laminarization takes place via their disappearance characterized by the 2D directed percolation scenario.https://cassyni-user-files-prod.s3.amazonaws.com/Jz6JKzCtZABERFFytCRGn2 https://cassyni.com/events/CZivB9DNCguVWKYgTRBGCM/seminar/qa https://cassyni.com/slides/outline/CZivB9DNCguVWKYgTRBGCM https://cassyni.com/events/CZivB9DNCguVWKYgTRBGCM/abstract https://cassyni-user-files-prod.s3.amazonaws.com/ZFtmdQaXQHnSZsQZwdCUv https://cassyni.com/events/CZivB9DNCguVWKYgTRBGCM?videoPreview=1 Dialysis Todaynohttps://cassyni.com/events/CZivB9DNCguVWKYgTRBGCM?videoPreview=12024-03-14T09:00:00+00:002026.04Imperial College Renal and Transplant CentreOpening remarks by the Clinical Vice President of UK Kidney Association - Professor James Burton Personal visions about where Dialysis care and research is headed in the next 10 yearshttps://cassyni-user-files-prod.s3.amazonaws.com/ZFtmdQaXQHnSZsQZwdCUv https://cassyni.com/events/KyUbz2S8Bv949NmYhrySEy/seminar/qa https://cassyni.com/slides/outline/KyUbz2S8Bv949NmYhrySEy https://cassyni.com/events/KyUbz2S8Bv949NmYhrySEy/abstract https://cassyni-user-files-prod.s3.amazonaws.com/KER6rL2emtTHFjuY8y1Y3p https://cassyni.com/events/KyUbz2S8Bv949NmYhrySEy?videoPreview=1 Freezing of dropsnohttps://cassyni.com/events/KyUbz2S8Bv949NmYhrySEy?videoPreview=12024-03-01T16:00:00+00:003783.72Journal of Fluid MechanicsAn immersed soft particle or oil droplet is severely deformed when engulfed into an advancing ice front. This deformation strongly depends on the engulfment velocity, even forming pointy-tip shapes for low velocities. We found that such singular deformations are mediated by interfacial flows in nanometric thin liquid films separating the nonsolidifying dispersed soft particles or droplets and the solidifying bulk. The competing forces in the thin film originate from the disjoining pressure and the surface tension gradient (Marangoni forces). We analytically modelled the fluid flow in these intervening thin films, using a lubrication approximation in the boundary layers. In an exact analytical calculation and with a formal analogy to a nonlinear pendulum, we then related the fluid flow to the deformation sustained by the dispersed droplet. We find it astounding that the nanoscopic interaction (van der Waals forces, disjoining pressure) determines the shape of the macroscopic immersed soft particle or droplet. We then extended this line of research to the interaction of several immersed soft particles or droplets over which a solidification front is passing. This time it is the relative thermal conductivity of the soft particles and the liquid which determines whether the two soft particles repel or attract. We call the effect the frozen Cheerios effect. Finally, we identified a freezing-induced topological transition of a double-emulsion, i.e., an oil droplet with an immersed water droplet inside, and as a whole immersed in water, passing through a freezing front. Whether the water droplet inside the oil droplet survives or whether it literally bursts due to pressure forces emerging at solidification depends on the control parameters, in particular the freezing front velocity. This is joint work with Jochem Meijer, Pallav Kant, Vincent Bertin, and Duco van Buuren, all Physic of Fluids group, University of Twente.https://cassyni-user-files-prod.s3.amazonaws.com/KER6rL2emtTHFjuY8y1Y3p https://cassyni.com/events/69KggtKRu6daWCJqoBd2W9/abstract https://cassyni-user-files-prod.s3.amazonaws.com/2Za6oMZXLvMoihz4akJMCS https://cassyni.com/slides/outline/VMiDX8BSKXt4DFd2w5rDfB https://cassyni.com/events/VMiDX8BSKXt4DFd2w5rDfB/abstract https://cassyni-user-files-prod.s3.amazonaws.com/FAQqdk4k2eBM3TQtv7ProY https://cassyni.com/events/VMiDX8BSKXt4DFd2w5rDfB?videoPreview=1 To the Continuum and Beyond!nohttps://cassyni.com/events/VMiDX8BSKXt4DFd2w5rDfB?videoPreview=12020-11-24T12:00:00+00:003277.2Granular MatterThe ability to predict granular flows efficiently has been a major challenge for years. An accurate and robust continuum model would be ideal, as it could lead to fast simulation of industrial and geo-scale problems. However, there are a number of granular flow behaviors that complicate the development of a continuum treatment including coupled history effects, nontrivial phase change, pressure-sensitive yielding, nonlocal effects, and shear banding phenomena. Rather than attempt to combine all these effects together, this talk will begin by identifying a class of problems that tend to be well-predicted using a very simple continuum treatment. These are problems based on intrusion, where the intrusive dynamics of solid objects (e.g. locomotion, impact) is the primary interest. We then discuss two ways to extend this basic continuum framework with nonstandard "add-ons", in order to handle various complications. First, we will discuss the state of affairs in nonlocal modeling approaches, and focus on some new results pertinent to the physics of nonlocality. Secondly, as an alternative to adding more complexity to the continuum model, we will discuss a hybridized DEM/continuum method that allows us to adaptively choose subdomains in a problem to be treated with continuum modeling vs discrete element modeling. This allows us to keep a simple and fast-to-solve continuum model almost everywhere, while providing a more precise DEM treatment in zones that fall outside the scope of the continuum model.https://cassyni-user-files-prod.s3.amazonaws.com/FAQqdk4k2eBM3TQtv7ProY https://cassyni.com/slides/outline/UNR1RktPScmuYVo2q7NtrH https://cassyni.com/events/UNR1RktPScmuYVo2q7NtrH/abstract https://cassyni-user-files-prod.s3.amazonaws.com/LYQ67BWcYxx1fnTqVirLUW https://cassyni.com/events/UNR1RktPScmuYVo2q7NtrH?videoPreview=1 AI-based End-to-End and AI-Enhanced Video Codingnohttps://cassyni.com/events/UNR1RktPScmuYVo2q7NtrH?videoPreview=12023-05-04T10:30:00+00:003201.64Journal on Image and Video ProcessingMoving Picture, Audio, and Data Coding by Artificial Intelligence is the Standards Developing Organisation whose mission is Data Coding by Artificial Intelligence. Founded in September 2020, it has developed and published 12 technical documents on audio enhancement, human-machine conversation, execution of AI applications, company performance prediction, neural network watermarking, and metaverse model. The talk on [MPAI](https://mpai.community) will briefly describe the mission, the organisation, and the scope of activities. Video internet traffic has grown rapidly, leading to increased strain on infrastructure, slower speeds, and higher costs. Video compression can alleviate this problem; deep learning-based coding tools have shown great potential to reduce bitrate and improve quality. MPAI is working to standardize these tools. In particular, MPAI-EVC is working to improve an existing video codec by 25% in terms of encoding gain by exploiting deep learning. Recently, neural network for video coding has been an active research topic, receiving attention from both academic society and industry entity. The end-to-end video coding (EEV) of MPAI exploits AI-based data coding technologies in an end-to-end fashion, namely fully neural network based video codec. MPAI-EEV is at the level of Functional Requirements. The essential use cases and related reference model are under construction. This talk elaborates recent advances in EEV and reports the model design, which outperforms the latest H.266/VVC standard in terms of MS-SSIM.https://cassyni-user-files-prod.s3.amazonaws.com/LYQ67BWcYxx1fnTqVirLUW https://cassyni.com/slides/outline/59wcFdUip6kA3ZsC1JYvEq https://cassyni.com/events/59wcFdUip6kA3ZsC1JYvEq/abstract https://cassyni-user-files-prod.s3.amazonaws.com/F7BaFmrBWr65ZoH5DwKpdk https://cassyni.com/events/59wcFdUip6kA3ZsC1JYvEq?videoPreview=1 Generative models in computer vision and biometricsnohttps://cassyni.com/events/59wcFdUip6kA3ZsC1JYvEq?videoPreview=12022-10-06T12:30:00+00:003468.52Journal on Image and Video ProcessingWith the developments in the field of generative modeling and with the appearance of powerful model architectures, such as Generative Adversarial Networks (GAN), a wide range of new techniques and inventive algorithms has emerged recently to solve diverse computer vision problems, including many problems in the area of biometrics. In this talk, I will first provide a short overview of recent advances in generative modeling and describe some of our research efforts that focus explicitly on generative models. Next, I will present examples of our recent work utilizing generative models and talk about: (i) face image editing with our GAN inversion based MaskFaceGAN technique that allows for photo realistic image manipulation and explicitly addresses the problem of attribute entanglement seen with many latent-space based editing solutions, (ii) computer vision for fashion and virtual try-on with our context-driven C-VTON model and (ii) bimodal ocular image generation (and annotation) with our Dual-Branch StlyGAN2 (DB-StyleGAN) model. Finally, I will elaborate on some of the existing challenges with generative models and highlight future research directions.https://cassyni-user-files-prod.s3.amazonaws.com/F7BaFmrBWr65ZoH5DwKpdk https://cassyni.com/slides/outline/4AeQAGBfwBe1Np3BuL5bRw https://cassyni.com/events/4AeQAGBfwBe1Np3BuL5bRw/abstract https://cassyni-user-files-prod.s3.amazonaws.com/KowYq4GvLaMeTZh5yYStGv https://cassyni.com/events/4AeQAGBfwBe1Np3BuL5bRw?videoPreview=1 Intersecting Frontiers: Biotech, Neurotech, and AI | Opportunities and Risksnohttps://cassyni.com/events/4AeQAGBfwBe1Np3BuL5bRw?videoPreview=12023-09-25T15:00:00+00:003465.4DeSci FoundationThe convergence of Biotechnology, Neurotechnology, and Artificial Intelligence has major implications for the future of humanity. This talk explores the long-term opportunities inherent to these fields by surveying emerging breakthroughs and their potential applications. Whether we can enjoy the benefits of these technologies depends on us: Can we overcome the institutional challenges that are slowing down progress without exacerbating civilizational risks that come along with powerful technological progress? https://cassyni-user-files-prod.s3.amazonaws.com/KowYq4GvLaMeTZh5yYStGv https://cassyni.com/slides/outline/EYG68cmh9oGRuKLKvS2V7T https://cassyni.com/events/EYG68cmh9oGRuKLKvS2V7T/abstract https://cassyni-user-files-prod.s3.amazonaws.com/QMvyPiTcu58PfD1aSUyWra https://cassyni.com/events/EYG68cmh9oGRuKLKvS2V7T?videoPreview=1 A survey on current results in Theory of Lieb-Thirring inequalitiesnohttps://cassyni.com/events/EYG68cmh9oGRuKLKvS2V7T?videoPreview=12023-06-15T15:00:00+00:003407.36Journal of Mathematical SciencesAfter an overview of current state in theory of Lieb-Thirring inequalities, we shall give proofs of two results where sharp constants are known.https://cassyni-user-files-prod.s3.amazonaws.com/QMvyPiTcu58PfD1aSUyWra https://cassyni.com/slides/outline/Mx1mwVzT92VzYNZCAspfA5 https://cassyni.com/events/Mx1mwVzT92VzYNZCAspfA5/abstract https://cassyni-user-files-prod.s3.amazonaws.com/ByxemcGGqqw3qeBH9adZwt https://cassyni.com/events/Mx1mwVzT92VzYNZCAspfA5?videoPreview=1 Exotic tetraquarks with some heavy quarks in lattice QCDnohttps://cassyni.com/events/Mx1mwVzT92VzYNZCAspfA5?videoPreview=12023-11-10T13:00:00+00:001071.76Physics ReportsWe review how lattice QCD can contribute to the prediction and the comprehension of tetraquarks, and related exotic hadrons , with at least one heavy quark. Since the discovery of quarks and the development of the QCD theory, there has been a large interest in exotic hadrons, initiated by the tetraquark models developed by Jaffe in 1977. Lattice QCD, being a first principle approach to solve non-perturbative QCD, has been crucial not only to compute precise results, but also to motivate and inspire research in hadronic physics, with particular interest in exotic hadrons. In the new millennium, this interest exploded with several experimental discoveries of tetraquark and pentaquark resonances with heavy quarks, starting with the $Z_c$ and $Z_b$. So far, lattice QCD has not yet been able to comprehend this $Z$ class of tetraquarks, and is developing new methods to determine their masses, decay widths and decay processes. The interest in tetraquarks was also fuelled by the lattice QCD prediction of a second class of tetraquarks such as the $T_{bb}$, boundstates in the sense of having no strong decays. Very recently, the $T_{cc}$ tetraquark first predicted with quark models in 1982 by Richard et al, was observed experimentally. We expect the lattice QCD community will be able to explore this $T$ class of tetraquarks in more detail and with very precise results. We report on all the different direct and indirect approaches that lattice QCD, so far with most focus on tetraquarks, has been employing to study exotic hadrons with at least one heavy quark. We also briefly review the experimental progress in observing tetraquarks and pentaquarks, and the basic theoretical paradigms of tetraquarks, including three different types of mechanisms (diquark, molecular and s pole), comparing them with the results of lattice QCD. We aim to show the journey of Lattice QCD in the exploration of these fascinating and subtle hadrons.https://cassyni-user-files-prod.s3.amazonaws.com/ByxemcGGqqw3qeBH9adZwt https://cassyni.com/slides/outline/KUmki5kpwjjTWDKQi62J9s https://cassyni.com/events/KUmki5kpwjjTWDKQi62J9s/abstract https://cassyni-user-files-prod.s3.amazonaws.com/FN3tHcaqXA1uXB8z6iek2a https://cassyni.com/events/KUmki5kpwjjTWDKQi62J9s?videoPreview=1 Introducing Transformative Plant Biotechnology: Establishing a transient genetic transformation protocol in Cannabis sativanohttps://cassyni.com/events/KUmki5kpwjjTWDKQi62J9s?videoPreview=12023-09-22T08:45:00+00:00718.2The New Phytologist Foundation*Cannabis sativa* is a multipurpose crop with numerous beneficial applications for people and the planet. The uses of Cannabis range from the pharmaceutical sector to the building materials industry. Agrobacterium-mediated transient transformation is a highly useful method for gene function studies, and has been established in many diverse plant species. However, because of the widespread ban of Cannabis cultivation and research over the past century, a high-throughput and reproducible transient transformation system in Cannabis has not been established and optimised to the same extent as for other plant species. Here, we describe a protocol for Agrobacterium tumefaciens mediated transient transformation in Cannabis leaves, using the RUBY reporter construct, which encodes the enzymes in the betalain biosynthesis pathway. The protocol utilises an “agroinjection” method, whereby Agrobacterium is injected into Cannabis leaves. To optimise this protocol, different induction buffers, cultivars of Cannabis, and developmental stages of Cannabis plants were tested to establish the optimal conditions to achieve reliable transient transformation. Transformation efficiency was determined by quantifying the amount of betalain pigment present in the transformed leaf tissue. Further, this protocol was tested for its efficacy for protein subcellular localisation assays using fluorescent protein markers. This method is an efficient and easy way of determining transformation efficiency and selecting transformants in Cannabis without specialised equipment, and can be used for assessing gene function and protein localisation assays. **Co-Authors**: Seán Kettle, Aditya Nayak, Alice Destailleur, Rainer Melzer, Susanne Schillinghttps://cassyni-user-files-prod.s3.amazonaws.com/FN3tHcaqXA1uXB8z6iek2a https://cassyni.com/slides/outline/StVpQLThXc3Hznqsfxt2Zs https://cassyni.com/events/StVpQLThXc3Hznqsfxt2Zs/abstract https://cassyni-user-files-prod.s3.amazonaws.com/QJVPhboR1AgmaYG2vrQ38z https://cassyni.com/events/StVpQLThXc3Hznqsfxt2Zs?videoPreview=1 Identifying maize yield and precipitation gapsnohttps://cassyni.com/events/StVpQLThXc3Hznqsfxt2Zs?videoPreview=12021-06-24T12:00:00+00:003981.12Discover Applied SciencesIn sub-Saharan Africa (SSA), precipitation is an important driver of agricultural production. In Uganda, maize production is essentially rain-fed. However, due to changes in climate, projected maize yield targets have not often been met as actual observed maize yields are often below simulated/projected yields. This outcome has often been attributed to parallel gaps in precipitation. This study aims at identifying maize yield and precipitation gaps in Uganda for the period 1998–2017. Time series historical actual observed maize yield data (hg/ha/year) for the period 1998–2017 were collected from FAOSTAT. Actual observed maize growing season precipitation data were also collected from the climate portal of World Bank Group for the period 1998–2017. The simulated or projected maize yield data and the simulated or projected growing season precipitation data were simulated using a simple linear regression approach. The actual maize yield and actual growing season precipitation data were now compared with the simulated maize yield data and simulated growing season precipitation to establish the yield gaps. The results show that three key periods of maize yield gaps were observed (period one: 1998, period two: 2004–2007 and period three: 2015–2017) with parallel precipitation gaps. However, in the entire series (1998–2017), the years 2008–2009 had no yield gaps yet, precipitation gaps were observed. This implies that precipitation is not the only driver of maize yields in Uganda. In fact, this is supported by a low correlation between precipitation gaps and maize yield gaps of about 6.3%. For a better understanding of cropping systems in SSA, other potential drivers of maize yield gaps in Uganda such as soils, farm inputs, crop pests and diseases, high yielding varieties, literacy, and poverty levels should be considered.https://cassyni-user-files-prod.s3.amazonaws.com/QJVPhboR1AgmaYG2vrQ38z https://cassyni.com/slides/outline/5ecqQwe8evDys2rhoQftR3 https://cassyni.com/events/5ecqQwe8evDys2rhoQftR3/abstract https://cassyni-user-files-prod.s3.amazonaws.com/HGnNL9Lq3ittj27d1Gx48N https://cassyni.com/events/5ecqQwe8evDys2rhoQftR3?videoPreview=1 Liquid Friction, Wettability and Surfaces Slippery to Liquidsnohttps://cassyni.com/events/5ecqQwe8evDys2rhoQftR3?videoPreview=12023-06-16T10:00:00+00:003063.0Leeds Institute for Fluid DynamicsWater is all around us. On a wet day we need coats to keep us dry, windscreen wipers to see and reservoirs to collect water to drink. There are few things more essential for life. However, when objects become small, the force of gravity gives way to the force of surface tension. In this world, Nature really does know how to manipulate water. Insects walk on water. Diving beetles breathe without the need for gills. Desert beetles drink from fog. Lotus leaves stay dry and stay clean. Galling aphids roll away their sticky liquid waste. And the Nepenthes Pitcher Plant eats ants for breakfast, lunch and dinner. In all these cases, the key is the natural adaptation of surfaces to control how they interact with water. In this talk, I will give an overview of how Nature inspires diverse strategies to manipulate droplets and liquids to engineer super-water repellent, superslippery, low friction and drag reducing surfaces. I will show how this allows solid-liquid interfacial interactions to be understood, the wetting of surfaces to be manipulated and the liquid-on-solid friction to be reduced. Acknowledgements: Many collaborators contributed to this work, which was part-funded by the UK Engineering and Physical Sciences Research Council (EPSRC).https://cassyni-user-files-prod.s3.amazonaws.com/HGnNL9Lq3ittj27d1Gx48N https://cassyni.com/slides/outline/4fKdKaM5n17qCH2hhSCZc9 https://cassyni.com/events/4fKdKaM5n17qCH2hhSCZc9/abstract https://cassyni-user-files-prod.s3.amazonaws.com/SbYDLmmUNt9HbWLvMNYvpW https://cassyni.com/events/4fKdKaM5n17qCH2hhSCZc9?videoPreview=1 How to Use Bibliometric Study for Writing a Paper: A Starter Guidenohttps://cassyni.com/events/4fKdKaM5n17qCH2hhSCZc9?videoPreview=12021-12-26T12:00:00+00:002399.28Cassyni SeminarsBibliometric analysis is an essential statistical tool to map the state of the art in a given area of scientific knowledge. Bibliometric is one family of measures that uses a variety of approaches for counting publication, citation, co-citation, bibliographic coupling, keyword co-occurrence, and co-authorship networks. Bibliometric methods involve the use of several tools that can help researchers to identify a relevant and current research problem. Bibliometric paper can be written before writing a literature review article and at the introduction section of any research papers. Researcher who develops a research project based on bibliometric analysis has the possibility of presenting the objectives and methods of his work clearly and concisely. In this workshop, you will learn “How to Use Bibliometric Study for Writing a Paper”.https://cassyni-user-files-prod.s3.amazonaws.com/SbYDLmmUNt9HbWLvMNYvpW https://cassyni.com/slides/outline/C53h1q3xMsRfgrZAfK4J29 https://cassyni.com/events/C53h1q3xMsRfgrZAfK4J29/abstract https://cassyni-user-files-prod.s3.amazonaws.com/XR4hehRyE8CYstyAxeHPh8 https://cassyni.com/events/C53h1q3xMsRfgrZAfK4J29?videoPreview=1 Solar Water Heating: Comprehensive Review, Critical Analysis and Case Studynohttps://cassyni.com/events/C53h1q3xMsRfgrZAfK4J29?videoPreview=12023-12-28T08:00:00+00:001312.72International Journal of ThermofluidsThe increasing global demand for renewable energy sources underscores the significance of Solar Water Heating Systems (SWHS), emphasizing the need for thorough research and analysis in this domain. SWHS play a pivotal role in addressing energy efficiency and environmental sustainability, making it imperative to conduct in-depth studies on their utilization. Hence, this paper aims to provide a comprehensive overview of SWHS. It starts by explaining the principles behind these systems, including their components and classification. Moreover, this review consolidates various studies that have been conducted on SWHS to highlight both their advantages and disadvantages. Additionally, a case study is conducted in which it takes into consideration important economic and environmental factors. In particular, it focuses on several scenarios present in Lebanon such as family homes, schools, restaurants hotels and gyms to estimate potential cost savings achieved through implementing SWHS as opposed to relying solely on electric heaters. Furthermore, this investigation also examines the corresponding payback period associated with adopting SWHS along with assessing the significant reduction in carbon dioxide emissions possible if these systems were widely implemented. The findings of the study demonstrate that there is a direct correlation between the extent to which SWHS are utilized and both the payback period and reduction in CO2 emissions. It was observed that when SWHS are used more frequently, with a high percentage of time (Pr=0.9), significant advantages can be achieved. For instance, for different types of establishments such as family homes, schools, restaurants, hotels, and gyms, it was estimated that average payback periods would be 14.2 years, 4.6 years, 9.2 years, 4.4 years, and 5.3 years, respectively. These results indicate that adopting a greater dependency on SWHSs not only leads to quicker cost recovery but also significantly contributes towards reducing carbon dioxide emissions. The analysis reveals that the yearly decrease in carbon dioxide emissions per individual is 0.16 t within a household, 0.016 t per student in an educational institution, 0.04 t per customer within a dining establishment, 0.37 t for each occupied bed in a hotel accommodation, and 0.11 t per individual at a gym. This paper serves as guidelines to SWH community. Additionally, it adds a practical insights into economic and environmental issues relevant to both Lebanon and countries with similar climates.https://cassyni-user-files-prod.s3.amazonaws.com/XR4hehRyE8CYstyAxeHPh8 https://cassyni.com/slides/outline/NSh16p9ryqypMqYhxywdLH https://cassyni.com/events/NSh16p9ryqypMqYhxywdLH/abstract https://cassyni-user-files-prod.s3.amazonaws.com/K8DPFi23hByFziyHv3P2fp https://cassyni.com/events/NSh16p9ryqypMqYhxywdLH?videoPreview=1 Turbulence driven by tides in planetary cores: wave turbulence vs. geostrophic turbulencenohttps://cassyni.com/events/NSh16p9ryqypMqYhxywdLH?videoPreview=12020-05-28T15:00:00+00:003960.28Leeds Institute for Fluid DynamicsNo abstracthttps://cassyni-user-files-prod.s3.amazonaws.com/K8DPFi23hByFziyHv3P2fp https://cassyni.com/slides/outline/NwLc9VoPRJXsMc5bZRERbb https://cassyni.com/events/NwLc9VoPRJXsMc5bZRERbb/abstract https://cassyni-user-files-prod.s3.amazonaws.com/JWQNwrTe9NHBai7dCDo6mc https://cassyni.com/events/NwLc9VoPRJXsMc5bZRERbb?videoPreview=1 The magnetorotational instability in the solar interior and the buckling of a nonlinear Euler-Bernoulli elastic beamnohttps://cassyni.com/events/NwLc9VoPRJXsMc5bZRERbb?videoPreview=12023-05-04T15:00:00+00:003117.4Leeds Institute for Fluid DynamicsNo abstracthttps://cassyni-user-files-prod.s3.amazonaws.com/JWQNwrTe9NHBai7dCDo6mc https://cassyni.com/slides/outline/Quw2LEPVB8kdTKMpvP6N29 https://cassyni.com/events/Quw2LEPVB8kdTKMpvP6N29/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Uxv2vPDkr81j2hVDPzu6GN https://cassyni.com/events/Quw2LEPVB8kdTKMpvP6N29?videoPreview=1 The Determination of the Electrochemically Active Surface Area and its Effects on the Electrocatalytic Properties of Structured Nickel Electrodes Produced by Additive Manufacturingnohttps://cassyni.com/events/Quw2LEPVB8kdTKMpvP6N29?videoPreview=12024-01-21T12:00:00+00:001864.68Electrochimica ActaAdditively manufactured (AM) nickel electrodes offer a great potential as an efficient solution for oxygen evolution catalysts in alkaline electrolyzers, since advanced fabrication methods allow the design of high surface area electrodes. The accurate determination of the electrochemical active surface area (ECSA) is a key step in the evaluation of the intrinsic catalytic activity of complex electrodes. In this work, we fabricated Ni electrodes with different macroscopic lattice structures using laser powder bed fusion of metals (PBF-LB/M). The selected designs allow exploring the effects of the electrode geometry on the electrochemical performance. X-ray photon spectroscopy (XPS) and a non-contact optical profilometer (NCOP) were used to investigate the composition and surface morphology of the electrodes. The ECSA was determined by three different approaches. 1. Linear and non-linear allometric fitting of the double layer capacitance from voltammetric experiments. 2. Integration of the Ni2+/Ni3+ transition, also from voltammetry. 3. Assessing double layer capacitance determined from electrochemical impedance spectroscopy (EIS) at open circuit potential (OCP) and the adsorption capacitance for the oxygen evolution reaction (OER) intermediates. Comparing these methods, large deviations in the resulting ECSAs were found, motivating a comprehensive discussion. In addition, four different reactions were investigated, ferri-ferrocyanide redox system, hydrogen evolution, ethanol electrooxidation, and oxygen evolution reaction. The obtained results demonstrate the potential of AM to tailor electrode performance by altering electrode geometry. The findings underline the importance of the ECSA determination for the comparison of the electrocatalytic activity in different electrodes.https://cassyni-user-files-prod.s3.amazonaws.com/Uxv2vPDkr81j2hVDPzu6GN https://cassyni.com/slides/outline/TPB3Zed7NRX7pFqPU4zzk5 https://cassyni.com/events/TPB3Zed7NRX7pFqPU4zzk5/abstract https://cassyni-user-files-prod.s3.amazonaws.com/8AAuPB8KP45jaCqbiF9fgr https://cassyni.com/events/TPB3Zed7NRX7pFqPU4zzk5?videoPreview=1 Recent Examples of eVTOL Aeroacousticsnohttps://cassyni.com/events/TPB3Zed7NRX7pFqPU4zzk5?videoPreview=12024-02-16T16:00:00+00:002786.08Department of AeronauticsThis seminar presents recent work carried out at the CFD Laboratory of Glasgow on eVTOL. The seminar will present a method for eVTOL rotor blade optimisation based on harmonic balance CFD, and demonstrate its use. Examples from aeroacoustics computations will them be given covering propeller and prop-rotor noise. https://cassyni-user-files-prod.s3.amazonaws.com/8AAuPB8KP45jaCqbiF9fgr https://cassyni.com/events/2gkqFUGsRXqAeoYewrQu4R/seminar/qa https://cassyni.com/slides/outline/2gkqFUGsRXqAeoYewrQu4R https://cassyni.com/events/2gkqFUGsRXqAeoYewrQu4R/abstract https://cassyni-user-files-prod.s3.amazonaws.com/WprDL28JDmHsg7DYDrSpSa https://cassyni.com/events/2gkqFUGsRXqAeoYewrQu4R?videoPreview=1 Physics and modeling of wind-blown sand dunesnohttps://cassyni.com/events/2gkqFUGsRXqAeoYewrQu4R?videoPreview=12024-01-25T15:00:00+00:004424.6Granular MatterSand dunes occur in desert and coastal areas of our planet thereby interacting with local infrastructure and contributing to desertification. To form, dunes require a supply of granular particles at the surface and a boundary layer of sufficient efficacy to enable transport of these particles by fluid forces. However, different dune shapes occur in nature depending on the wind regimes and the amount of sand available for transport. Numerical simulations of wind-blown sand transport and the concatenated dune migration have been pushing forward our understanding of dune physics, as I will discuss in the talk. Moreover, dunes have been detected in surprising locations of our solar system, including on Mars and even on Pluto, where the atmosphere is 100,000 times less dense than the Earth’s and the granular material is made of methane ice. Therefore, I will present insights we have gained about the formative processes of dunes on Earth and in extra-terrestrial environments, and discuss open questions and promising applications in the planetary and desertification research.https://cassyni-user-files-prod.s3.amazonaws.com/WprDL28JDmHsg7DYDrSpSa https://cassyni.com/slides/outline/DZ28GWWR5c1eB5NgZPeb1F https://cassyni.com/events/DZ28GWWR5c1eB5NgZPeb1F/abstract https://cassyni-user-files-prod.s3.amazonaws.com/3PyJBCGwVdQ8255JMEMACn https://cassyni.com/events/DZ28GWWR5c1eB5NgZPeb1F?videoPreview=1 On the sharp estimates for convolution operators with oscillatory kernelnohttps://cassyni.com/events/DZ28GWWR5c1eB5NgZPeb1F?videoPreview=12023-03-09T15:00:00+00:003293.24Journal of Mathematical SciencesIn this talk, we discuss the 𝐿𝑝 ↦ 𝐿𝑝′-boundedness problem for the convolution operator 𝑀𝑘 (where 𝑘-means that the smooth amplitude function is homogeneous of order −𝑘 for large values of the argument) with oscillatory kernel. We study the convolution operators, assuming that the characteristic surface 𝑆 ⊂ ℝ3 is contained in a sufficiently small neighborhood of a given point 𝑥0 ∈ 𝑆 at which exactly one of the principal curvatures of 𝑆 does not vanish. Such surfaces exhibit singularities of type 𝐴 in the sense of Arnol'd's classification. Denoting by 𝑘𝑝 the minimal exponent such that 𝑀𝑘 is 𝐿𝑝 ↦ 𝐿𝑝′-bounded for 𝑘 > 𝑘𝑝, we show that the number 𝑘𝑝 depends on some discrete characteristics of the surface.https://cassyni-user-files-prod.s3.amazonaws.com/3PyJBCGwVdQ8255JMEMACn https://cassyni.com/slides/outline/Lxmp5PjB4qFCp8bYoqSm3s https://cassyni.com/events/Lxmp5PjB4qFCp8bYoqSm3s/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Ls65QKV4mmhRkma6GfFfok https://cassyni.com/events/Lxmp5PjB4qFCp8bYoqSm3s?videoPreview=1 Click Chemistrynohttps://cassyni.com/events/Lxmp5PjB4qFCp8bYoqSm3s?videoPreview=12022-02-22T15:00:00+00:007155.68Thieme GroupClickchemistry is a discipline that has developed rapidly over the past two decades. In this Thieme WebCheminar, Floris Rutjes (SOS Editor of ‘Click Chemistry’) and SOS authors Hannes Mikula and John Moses will discuss recent progress in click and bioorthogonal chemistry.https://cassyni-user-files-prod.s3.amazonaws.com/Ls65QKV4mmhRkma6GfFfok https://cassyni.com/slides/outline/PS1qJoxoG81hB557MXMPmo https://cassyni.com/events/PS1qJoxoG81hB557MXMPmo/abstract https://cassyni-user-files-prod.s3.amazonaws.com/NiX6KtAHREmqhhBz6XaNdU https://cassyni.com/events/PS1qJoxoG81hB557MXMPmo?videoPreview=1 Modern Nickel-Catalyzed Reactionsnohttps://cassyni.com/events/PS1qJoxoG81hB557MXMPmo?videoPreview=12023-03-23T15:00:00+00:008099.28Thieme GroupDue to its relatively abundant and inexpensive nature, nickel has been of high interest as transition metal for homogeneous catalysis in the field of organic synthesis.https://cassyni-user-files-prod.s3.amazonaws.com/NiX6KtAHREmqhhBz6XaNdU https://cassyni.com/events/Wqju14ffqzKXfebaKQD8Bo/abstract https://cassyni-user-files-prod.s3.amazonaws.com/TuXpFwASpwjNjppxpNMcWJ https://cassyni.com/slides/outline/RQcFVYYu1xETGnMLiVDLCM https://cassyni.com/events/RQcFVYYu1xETGnMLiVDLCM/abstract https://cassyni-user-files-prod.s3.amazonaws.com/3djenGWnJcePqcZNkyEEAS https://cassyni.com/events/RQcFVYYu1xETGnMLiVDLCM?videoPreview=1 Reconfigurable Metamaterials in Magnetic Resonance Imaging - Benefits and current developments-nohttps://cassyni.com/events/RQcFVYYu1xETGnMLiVDLCM?videoPreview=12024-02-27T03:00:00+00:003107.96The Auckland Bioengineering InstituteReconfigurable metamaterials offer many degrees of freedom and allow to overcome limitations of present technological capabilities in Magnetic Resonance Imaging (MRI). Various metrics such as speed, efficiency, and local signal-to-noise ratio (SNR) can be drastically improved and tailored applications rather than global effects become possible. So far, in the literature there exist a few metamaterial realizations for MRI, and only a small subset includes non-static mechanisms and a very low degree of reconfigurability, if any. At least, resonance frequency fine-tuning must be provided to handle patient-specific and vendor-related effects. Manual control is too far from clinical use. Only a digital and wireless interface, supplemented by an on-board logic, will have a meaningful impact. True reconfigurability does not only include tuning at the unit cell level and dynamic spatial sensitivity profiles w.r.t. the interaction with the incident transmit and/ or receive fields, but also the precise control in the time domain. Thereupon, the integration into some sequence control and development framework is mandatory, ideally in a vendor-independent way. The state of the art, potential benefits, and various use-cases of static, dynamic, reconfigurable, and interactive metamaterials as well as control strategies are presented. Applications range from simple SNR enhancement to spatial encoding patterns for reduced gradient fields. First-generation prototypes of such metamaterials demonstrate the working principle, and on-bench characterization results as well as MRI measurements are shown. For a specific application, a pre-defined target function must be extremized. A prime example is a desired spatio-temporal sensitivity profile for SNR modifications. Thus, suitable optimization strategies have to be implemented, which include conventional as well as AI-driven approaches. Simulations, on-bench measurements, deep learning results, and MRI verification are demonstrated for a proof-of-principle application. https://cassyni-user-files-prod.s3.amazonaws.com/3djenGWnJcePqcZNkyEEAS https://cassyni.com/events/CqeE3rBWX6Z76bVnhv2n1/seminar/qa https://cassyni.com/slides/outline/CqeE3rBWX6Z76bVnhv2n1 https://cassyni.com/events/CqeE3rBWX6Z76bVnhv2n1/abstract https://cassyni-user-files-prod.s3.amazonaws.com/APTZRsA8UuPrWRFVWx8mkA https://cassyni.com/events/CqeE3rBWX6Z76bVnhv2n1?videoPreview=1 Multiple evolutionary transitions of reproductive strategies in a phylum of aquatic colonial invertebratesnohttps://cassyni.com/events/CqeE3rBWX6Z76bVnhv2n1?videoPreview=12024-03-04T11:00:00+00:003729.48Royal Society PublishingParental care is considered crucial for the enhanced survival of offspring and evolutionary success of many metazoan groups. Most bryozoans incubate their young in brood chambers or intracoelomically. Based on the drastic morphological differences in incubation chambers across members of the order Cheilostomatida (class Gymnolaemata), multiple origins of incubation were predicted in this group. This hypothesis was tested by constructing a molecular phylogeny based on mitogenome data and nuclear rRNA genes 18S and 28S with the most complete sampling of taxa with various incubation devices to date. Ancestral character estimation suggested that distinct types of brood chambers evolved at least 10 times in Cheilostomatida. In Eucratea loricata and Aetea spp. brooding evolved unambiguously from a zygote-spawning ancestral state, as it probably did in Tendra zostericola, Neocheilostomata, and ‘Carbasea' indivisa. In two further instances, brooders with different incubation chamber types, skeletal and non-skeletal, formed clades (Scruparia spp., Leiosalpinx australis) and (Catenicula corbulifera (Steginoporella spp. (Labioporella spp., Thalamoporella californica))), each also probably evolved from a zygote-spawning ancestral state. The modular nature of bryozoans probably contributed to the evolution of such a diverse array of embryonic incubation chambers, which included complex constructions made of polymorphic heterozooids, and maternal zooidal invaginations and outgrowths.https://cassyni-user-files-prod.s3.amazonaws.com/APTZRsA8UuPrWRFVWx8mkA https://cassyni.com/events/3g5fTU5ohos3U354LPpfVw/seminar/qa https://cassyni.com/slides/outline/3g5fTU5ohos3U354LPpfVw https://cassyni.com/events/3g5fTU5ohos3U354LPpfVw/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Eyh1GYMGaudfA2xh2siH4A https://cassyni.com/events/3g5fTU5ohos3U354LPpfVw?videoPreview=1 A Tale of Two Generations: Parallel and Divergent Paths of a Family of Ethiopian Immigrant Entrepreneursnohttps://cassyni.com/events/3g5fTU5ohos3U354LPpfVw?videoPreview=12024-04-10T16:00:00+00:003200.16Lived Places PublishingIn this conversation between **Drew Harris**, The Emergent Entrepreneur Collection Editor at Lived Places Publishing and **Yoni Medhin**, author of *An Ethiopian Family's Journey of Entrepreneurship in the US: A Story of Determination, Resourcefulness, and Faith*, they discuss how Yoni's entrepreneurial journey as a second generation immigrant was shaped by, but different from, his parents’ entrepreneurial journey as first generation immigrants.https://cassyni-user-files-prod.s3.amazonaws.com/Eyh1GYMGaudfA2xh2siH4A https://cassyni.com/slides/outline/AbA87399rDcpxr4dhqPbed https://cassyni.com/events/AbA87399rDcpxr4dhqPbed/abstract https://cassyni-user-files-prod.s3.amazonaws.com/RnMG5tYgMmdAsKtq4hii3Y https://cassyni.com/events/AbA87399rDcpxr4dhqPbed?videoPreview=1 Reflecting on a Novennium at the ABI: Lessons in Imaging, Modeling, and Lifenohttps://cassyni.com/events/AbA87399rDcpxr4dhqPbed?videoPreview=12024-04-16T04:00:00+00:003801.12The Auckland Bioengineering InstituteIn this seminar, Dr Geoffrey Handsfield presents work and life lessons learned over 9 years spent working at the ABI, from a Whitaker International Scholar to a Research Fellow and Senior Research Fellow. This talk will cover methods for determining skeletal muscle fibre architecture using Diffusion Tensor MRI, thoughts on modeling skeletal muscle physiology, working with groups with disabilities, and a brief epilogue on the practice and science of forest bathing from Dr Handsfield's perspective as a forest bathing/ forest therapy guide. Interspersed, there will surely be some philosophical reflections on life and the ups and downs of being an early/mid - career researcher. https://cassyni-user-files-prod.s3.amazonaws.com/RnMG5tYgMmdAsKtq4hii3Y https://cassyni.com/events/B5oj9ingHgAsxcbXJGgPuw/abstract https://cassyni-user-files-prod.s3.amazonaws.com/8epWRrmqpWdqFC8iDnLCES https://cassyni.com/events/J1Mmjzc6HDg1wEr5ZXbWa1/seminar/qa https://cassyni.com/slides/outline/J1Mmjzc6HDg1wEr5ZXbWa1 https://cassyni.com/events/J1Mmjzc6HDg1wEr5ZXbWa1/abstract https://cassyni-user-files-prod.s3.amazonaws.com/PpyhgRNDQX24Tv6zEzEZMY https://cassyni.com/events/J1Mmjzc6HDg1wEr5ZXbWa1?videoPreview=1 Synthetic Development of Key Intermediates and Active Pharmaceutical Ingredientsnohttps://cassyni.com/events/J1Mmjzc6HDg1wEr5ZXbWa1?videoPreview=12024-05-29T09:00:00+00:004353.28Thieme GroupThe development of efficient and sustainable synthetic processes for pharmaceuticals is a critical area of research, primarily driven by the pharmaceutical industry. However, fostering such research in academic institutions holds immense potential. The SYNTHESIS special issue on "Synthetic Development of Key Intermediates and Active Pharmaceutical Ingredients (APIs)" highlighted recent advancements in this field. In this Thieme Cheminar chaired by Prof. Laha (Guest Editor “Synthetic Development of Key Intermediates and Active Pharmaceutical Ingredients (APIs)” collection) our speakers will share discuss their recent results in this field. Chair: * Prof. Joydev Kumar Laha (National Institute of Pharmaceutical Education and Research, India) Our speakers: * Dr. Luca Laraia (Technical University of Denmark): Next-generation strategies for the synthesis of functional, natural product inspired compounds. * Dr. Sharada Prasanna Swain (National Institute of Pharmaceutical Education and Research): Photocatalyzed Continuous-flow synthesis of Pharmaceuticals. * Dr. Gangarajula Sudhakar (CSIR- Indian Institute of Chemical Technology): The role of synthetic steps order in developing key intermediates and active pharmaceutical ingredients. * Dr. Nilanjana Majumdar (CSIR-Central Drug Research Institute): Unactivated Carboxylic Acids in Catalytic Asymmetric Ring Opening Reactions. https://cassyni-user-files-prod.s3.amazonaws.com/PpyhgRNDQX24Tv6zEzEZMY https://cassyni.com/events/XLs5zT5G8acypT9fikjqEm/seminar/qa https://cassyni.com/slides/outline/XLs5zT5G8acypT9fikjqEm https://cassyni.com/events/XLs5zT5G8acypT9fikjqEm/abstract https://cassyni-user-files-prod.s3.amazonaws.com/93BppCjuLUEcqUgme4ChLi https://cassyni.com/events/XLs5zT5G8acypT9fikjqEm?videoPreview=1 Interpreting in NZ: research on training and practicenohttps://cassyni.com/events/XLs5zT5G8acypT9fikjqEm?videoPreview=12024-09-13T04:10:00+00:002930.04Linguistics and Applied Language StudiesThe population of New Zealand is now highly linguistically diverse, yet we have a relatively under-developed professional infrastructure for interpreting services which are critical to equitable access to society. In these two short talks by doctoral candidates, we will hear about their research into aspects of interpreter training and court interpreting practices in New Zealand. https://cassyni-user-files-prod.s3.amazonaws.com/93BppCjuLUEcqUgme4ChLi https://cassyni.com/slides/outline/E4AwNXRtmZEs9aPQAR1Ty7 https://cassyni.com/events/E4AwNXRtmZEs9aPQAR1Ty7/abstract https://cassyni-user-files-prod.s3.amazonaws.com/4tqXjZogBRiJiJAdihRWvi https://cassyni.com/events/E4AwNXRtmZEs9aPQAR1Ty7?videoPreview=1 Modeling Synchronization in Turbulent Flowsnohttps://cassyni.com/events/E4AwNXRtmZEs9aPQAR1Ty7?videoPreview=12020-09-18T14:00:00+00:00641.28Brunton LabBenjamin Herrmann describes a data-driven modeling procedure for fluid dynamics. In particular, he discusses how to model synchronization in forced turbulent oscillator flows using a data-driven extended Stuart-Landau equation.https://cassyni-user-files-prod.s3.amazonaws.com/4tqXjZogBRiJiJAdihRWvi https://cassyni.com/events/Rum4bZUNhuTgFHN4KWaDAD/seminar/qa https://cassyni.com/slides/outline/Rum4bZUNhuTgFHN4KWaDAD https://cassyni.com/events/Rum4bZUNhuTgFHN4KWaDAD/abstract https://cassyni-user-files-prod.s3.amazonaws.com/PGQe659RWDU8XuhyyGqZHG https://cassyni.com/events/Rum4bZUNhuTgFHN4KWaDAD?videoPreview=1 Integrating Evidence-based Practices for Literacy and Mental Health Promotion in Early Childhoodnohttps://cassyni.com/events/Rum4bZUNhuTgFHN4KWaDAD?videoPreview=12024-11-14T21:00:00+00:002824.4Family MedicineThis talk presents work conducted by Dr. Chou in partnership with agencies in Liberty City, a predominantly Black neighborhood in Miami, FL impacted by high rates of poverty and gun violence. Content will focus on the formation of a reciprocal collaboration with community partners, design of a children's book and dialogic reading protocol aiming to advance affective knowledge among preschool- and Kindergarten-age children, and evaluation in the context of local challenges. Objectives: At the conclusion of this session, attendees will be able to: - Advance their understanding of wise interventions and their potential application to primary care. - Discuss caregiver strategies to promote emotional knowledge and literacy in young children. - Describe dialogic reading strategies to enhance learning in caregiver-child book reading.https://cassyni-user-files-prod.s3.amazonaws.com/PGQe659RWDU8XuhyyGqZHG https://cassyni.com/slides/outline/TtKrffYb4NkLnkr756Mshw https://cassyni.com/events/TtKrffYb4NkLnkr756Mshw/abstract https://cassyni-user-files-prod.s3.amazonaws.com/SokBrSecPAh6BoJacsrMG2 https://cassyni.com/events/TtKrffYb4NkLnkr756Mshw?videoPreview=1 AI/ML+Physics Part 4: Crafting a Loss Functionnohttps://cassyni.com/events/TtKrffYb4NkLnkr756Mshw?videoPreview=12024-03-22T12:00:00+00:001391.4Brunton LabThis video discusses the fourth stage of the machine learning process: (4) designing a loss function to assess the performance of the model. There are opportunities to incorporate physics into this stage of the process, such as adding regularization terms to promote sparsity or extra loss functions to ensure that a partial differential equation is satisfied, as in PINNs. SLB acknowledges support from the National Science Foundation AI Institute in Dynamic Systems and from The Boeing Company.https://cassyni-user-files-prod.s3.amazonaws.com/SokBrSecPAh6BoJacsrMG2 https://cassyni.com/events/EYrAXqbJcNigy3NuxX8S9K/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Lv5mJupwL7mkHAb8FmwK2n https://cassyni.com/events/hxqDSFmo7Q1Fu9bC4Sjpy/seminar/qa https://cassyni.com/slides/outline/hxqDSFmo7Q1Fu9bC4Sjpy https://cassyni.com/events/hxqDSFmo7Q1Fu9bC4Sjpy/abstract https://cassyni-user-files-prod.s3.amazonaws.com/KckTdwHCeMqujMkrutUbYi https://cassyni.com/events/hxqDSFmo7Q1Fu9bC4Sjpy?videoPreview=1 A Modern, Portable, and Scalable Framework for Extreme-Scale Computational Fluid Dynamicsnohttps://cassyni.com/events/hxqDSFmo7Q1Fu9bC4Sjpy?videoPreview=12024-06-12T12:45:00+00:003650.76Nektar++ Development TeamRecent trends and advancements in including more diverse and heterogeneous hardware in High-Performance Computing are challenging scientific software developers in their pursuit of good performance and efficient numerical methods. As a result, the well-known maxim "software outlives hardware" may no longer necessarily hold true, and researchers are today forced to re-factor their codes to leverage these powerful new heterogeneous systems. We present Neko - a portable framework for high-fidelity spectral element flow simulations. Unlike prior works, Neko adopts a modern object-oriented Fortran 2008 approach, allowing multi-tier abstractions of the solver stack and facilitating various hard- ware backends ranging from general-purpose processors, accelerators down to exotic vector processors and Field Programmable Gate Arrays (FPGAs) via Neko’s device abstraction layer. Focusing on Neko’s performance and exascale readiness, we outline the optimisation and algorithmic work necessary to ensure scalability and performance portability across a wide range of platforms. Finally, we present performance measurements on a wide range of accelerated computing platforms, including the EuroHPC pre-exascale system LUMI and Leonardo, where Neko achieves excellent parallel efficiency for an extreme-scale direct numerical simulation (DNS) of turbulent thermal convection using up to 80% of the entire LUMI supercomputer.https://cassyni-user-files-prod.s3.amazonaws.com/KckTdwHCeMqujMkrutUbYi https://cassyni.com/slides/outline/GXQxbwfWxr1MWWrxi6v6h3 https://cassyni.com/events/GXQxbwfWxr1MWWrxi6v6h3/abstract https://cassyni-user-files-prod.s3.amazonaws.com/8nMM2eJg4AbAfSwbY9AEEJ https://cassyni.com/events/GXQxbwfWxr1MWWrxi6v6h3?videoPreview=1 Sailfish generate foraging opportunities for seabirds in multi-species predator aggregationsnohttps://cassyni.com/events/GXQxbwfWxr1MWWrxi6v6h3?videoPreview=12024-06-27T12:00:00+00:00990.12Royal Society PublishingWhile various marine predators form associations, the most commonly studied are those between subsurface predators and seabirds. However, the mechanisms underlying these associations remain poorly understood. Three hypotheses have been proposed to explain the prevalence of these associations: (1) subsurface predators herd prey to the surface and make prey accessible to birds, (2) subsurface predators damage prey close to the surface and thereby provide food scraps to birds, and (3) attacks of underwater predators lower the cohesion of prey groups and thereby their collective defences making the prey easier to be captured by birds. Utilising drone footage, we investigated the interaction between Indo-Pacific sailfish (Istiophorus platypterus) and terns (Onychoprion sp.) preying on schooling fish off the eastern coast of the Malaysian peninsula. Through spatio-temporal analysis of the hunting behaviour of the two predatory species and direct measures of prey cohesion we showed that terns attacked when school cohesion was low, and that this decrease in cohesion was frequently caused by sailfish attacks. Therefore, we propose that sailfish created a by-product benefit for the bird species, lending support for the hypothesis that lowering cohesion can facilitate associations between subsurface predators and seabirds.https://cassyni-user-files-prod.s3.amazonaws.com/8nMM2eJg4AbAfSwbY9AEEJ https://cassyni.com/slides/outline/97gtugxeNyhqkUg49wJUEy https://cassyni.com/events/97gtugxeNyhqkUg49wJUEy/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Si2detzFwk5HVYVNTgQGTQ https://cassyni.com/events/97gtugxeNyhqkUg49wJUEy?videoPreview=1 Practical Leveraged-Based Sampling for Low-Rank Tensor Decompositionnohttps://cassyni.com/events/97gtugxeNyhqkUg49wJUEy?videoPreview=12021-02-05T14:00:00+00:003504.48AI Institute in Dynamic SystemsConventional algorithms for finding low-rank canonical polyadic (CP) tensor decompositions are unwieldy for large sparse tensors. The CP decomposition can be computed by solving a sequence of overdetermined least problems with special Khatri-Rao structure. In this work, we present an application of randomized algorithms to fitting the CP decomposition of sparse tensors, solving a significantly smaller sampled least squares problem at each iteration with probabilistic guarantees on the approximation errors. Prior work has shown that sketching is effective in the dense case, but the prior approach cannot be applied to the sparse case because a fast Johnson-Lindenstrauss transform (e.g., using a fast Fourier transform) must be applied in each mode, causing the sparse tensor to become dense. Instead, we perform sketching through leverage score sampling, crucially relying on the fact that the structure of the Khatri-Rao product allows sampling from overestimates of the leverage scores without forming the full product or the corresponding probabilities. Naive application of leverage score sampling is ineffective because we often have cases where a few scores are quite large, so we propose a novel hybrid of deterministic and random leverage-score sampling which consistently yields improved fits. Numerical results on real-world large-scale tensors show the method is significantly faster than competing methods without sacrificing accuracy. This is joint work with Brett Larsen, Stanford University.https://cassyni-user-files-prod.s3.amazonaws.com/Si2detzFwk5HVYVNTgQGTQ https://cassyni.com/slides/outline/Bavv97CGaGUL7R9chdD6xu https://cassyni.com/events/Bavv97CGaGUL7R9chdD6xu/abstract https://cassyni-user-files-prod.s3.amazonaws.com/7akzSDzDx8MaCQEvj4xCQN https://cassyni.com/events/Bavv97CGaGUL7R9chdD6xu?videoPreview=1 Regulation via repression: Regulator of symbiosome differentiation (RSD) acts as zone-specific repressor to mediate nodule developmentnohttps://cassyni.com/events/Bavv97CGaGUL7R9chdD6xu?videoPreview=12024-06-07T14:15:00+00:00724.76New Phytologist Foundation This talk will be pre-recorded, with virtual Q&A. Medicago truncatula forms indeterminate nodules having successive development zones. Indeterminate nodules maintain an oxygen gradient to uncouple symbiosome differentiation at invasion zone and nitrogen fixation at fixation zone. The oxygen gradient maxima to minima from apex to base of nodule length depends on *leghemoglobins (LgHbs )* expression which is responsible for oxygen buffering as LgHbs create micro-oxic environment. In this study, we demonstrate the mode of action of Regulator of Symbiosome Differentiation (RSD), a transcriptional repressor. RSD interacts with Nodule Inception (NIN) and NIN-like protein 2 (NLP2). Studies confirm NIN-NLP2 activate *LgHbs* expression. RSD expression and protein localization remains confined within invasion and interzone. We identified this zone-specific expression of RSD is crucial as RSD represses *LgHb* expression at invasion zone. Manipulation of the stoichiometry of RSD, NIN, and NLP2 in planta disrupts *LgHb* expression and impairs functional nodule development. To unravel, the dynamics of the invasion zone-specific regulation, we performed translatome and transcriptome profiling using the RSD promoter, to identify putative targets of RSD. Collectively, our findings suggest that RSD-mediated repression of NIN and NLP2-targets are crucial for symbiosome differentiation. RSD recruitment in the nitrogen-fixing clade also recommends its evolution during nodulation and conserved functionality in other legume species as well. Thus RSD, as a repressor from its invasion zone optimizes the genetic network crucial for functional nodule development.https://cassyni-user-files-prod.s3.amazonaws.com/7akzSDzDx8MaCQEvj4xCQN https://cassyni.com/slides/outline/PwAeQptGx5Ev9a5pxYiGjf https://cassyni.com/events/PwAeQptGx5Ev9a5pxYiGjf/abstract https://cassyni-user-files-prod.s3.amazonaws.com/MY5JzY1oMJzLSJpr7WL5Hg https://cassyni.com/events/PwAeQptGx5Ev9a5pxYiGjf?videoPreview=1 Identifying novel regulators of exocytosis through a chemical genetic screen in Arabidopsisnohttps://cassyni.com/events/PwAeQptGx5Ev9a5pxYiGjf?videoPreview=12024-06-08T16:30:00+00:00940.0New Phytologist Foundation Exocytosis is a process necessary for the efficient delivery of new membrane, membrane proteins, and extracellular matrix components to the plasma membrane (PM) and cell wall. The process encompasses packaging of cargo into secretory vesicles at the trans-Golgi network as well as their transport, tethering, docking, and fusion with the PM. The exocyst complex facilitates the tethering of secretory vesicles to the PM. A small molecule, Endosidin2 (ES2), serves as an exocyst inhibitor and binds to the EXO70A1 subunit of the exocyst complex. To identify additional exocytosis regulators, we carried out a forward chemical genetic screen to identify ES2-hypersensitive mutants from ethyl methanesulfonate (EMS)-mutagenized Arabidopsis lines. We developed a pipeline for the identification and mapping of drug-hypersensitive mutants, and obtained a fully sequenced and mapped EMS mutant population to be used for future studies. Mutants hypersensitive to ES2 were named es2s. One such mutant, es2s-15, had a strong ES2 hypersensitive phenotype for root. We mapped the causal mutation to argj and identified a second allele with similar phenotypes. Surprisingly, ArgJ is an enzyme in the arginine biosynthesis pathway. Supplementation with arginine rescued the ES2 hypersensitive phenotype of both argj alleles. Taken together, our results indicate that impaired arginine biosynthesis leads to exocytosis defects.https://cassyni-user-files-prod.s3.amazonaws.com/MY5JzY1oMJzLSJpr7WL5Hg https://cassyni.com/events/F3VmaXEq3qGjxouoYxREQd/seminar/qa https://cassyni.com/slides/outline/F3VmaXEq3qGjxouoYxREQd https://cassyni.com/events/F3VmaXEq3qGjxouoYxREQd/abstract https://cassyni-user-files-prod.s3.amazonaws.com/BnHtrb92uLE84VZKV7TQJS https://cassyni.com/events/F3VmaXEq3qGjxouoYxREQd?videoPreview=1 The Logic of God: A Pluralistic Representational Theory of Conceptsnohttps://cassyni.com/events/F3VmaXEq3qGjxouoYxREQd?videoPreview=12024-07-24T14:00:00+00:005048.04Logica UniversalisIn this paper I present a formalization of the theory of ideal concepts applied to the concept of God. It is done within a version of the Simplest Quantified Modal Logic (SQML) and attempts to solve three meta-problems related to the concept of God: the unicity of extension problem, the homogeneity/heterogeneity problem and the problem of conceptual unity.https://cassyni-user-files-prod.s3.amazonaws.com/BnHtrb92uLE84VZKV7TQJS https://cassyni.com/slides/outline/UP15pyhzuCEAcDqcsCUqt9 https://cassyni.com/events/UP15pyhzuCEAcDqcsCUqt9/abstract https://cassyni-user-files-prod.s3.amazonaws.com/AtBE8SpB5EkymFzp8KpwNn https://cassyni.com/events/UP15pyhzuCEAcDqcsCUqt9?videoPreview=1 Employment Practices, Cost Minimization, and Their Implications for Food Provisions and Seafarers’ Wellbeing on board Ships – A Qualitative Analysisnohttps://cassyni.com/events/UP15pyhzuCEAcDqcsCUqt9?videoPreview=12024-07-25T12:00:00+00:001480.28Sage PublishingThe global shipping industry, responsible for delivering over 70% of the world’s goods (in volume), has increasingly adopted cost minimization policies, contributing to precarious employment practices that adversely affect seafarers’ wellbeing. This study focuses on the intricate relationship between employment precarity and food provision on cargo ships. By presenting seafarers’ perspectives, we aim to understand how precarious employment practices and cost minimization in the industry influence power dynamics related to food and impact seafarers’ wellbeing. Drawing on empirical data collected through shipboard observations and interviews with seafarers, this study examines the often-overlooked experiences and perspectives of seafarers. The research sheds light on the precarity of employment in shipping and its inherent impact on the provision of food on board and its implications for seafarers’ physical and emotional health, including the availability of nutritious and sufficient food and its impact on their daily lives. Through in-depth interviews, seafarers’ insights into their experiences of food including the quality, availability, and cultural appropriateness of food on board are explored, as well as the standard of training for cooks. Through this research, we found substandard conditions on some of the ships, cost-focused decision-making, and lack of standardized food preparation practices on board. These findings underline the need for improved regulations, better training opportunities, and increased consideration for seafarers’ wellbeing. These changes are essential to ensure the provision of adequate and nutritious meals that promote the physical and mental health of seafarers on board ships. Specifically, the research underscores the need for policy and advocacy initiatives to improve seafarers’ lives and promote fair working conditions in the global shipping industry. By amplifying the voices of seafarers and providing evidence-based insights, this study contributes to the larger discourse on workers’ rights and the importance of decent working conditions. It calls for greater attention to the provision of adequate, nutritious, and culturally appropriate food on board cargo ships, recognizing its significance for seafarers’ physical and mental wellbeing, as well as a call for standardized training for ship’s cooks.https://cassyni-user-files-prod.s3.amazonaws.com/AtBE8SpB5EkymFzp8KpwNn https://cassyni.com/slides/outline/7dmhtGXxTxxuUEPLb5ZVzd https://cassyni.com/events/7dmhtGXxTxxuUEPLb5ZVzd/abstract https://cassyni-user-files-prod.s3.amazonaws.com/2cTBzwbBJmJMYbM2oZbBq8 https://cassyni.com/events/7dmhtGXxTxxuUEPLb5ZVzd?videoPreview=1 PCAN Podcast Episode 6: Variation in communication of side effects in prostate cancer treatment consultationsnohttps://cassyni.com/events/7dmhtGXxTxxuUEPLb5ZVzd?videoPreview=12024-05-19T14:00:00+00:001820.92Research Seminars by Springer NatureNo abstracthttps://cassyni-user-files-prod.s3.amazonaws.com/2cTBzwbBJmJMYbM2oZbBq8 https://cassyni.com/events/9cN85184DoBfZwfZx3RSRB/abstract https://cassyni-user-files-prod.s3.amazonaws.com/8aMfj9hmVZuQNJo4ECju6E https://cassyni.com/slides/outline/C5dmR3sZpSsvkabkhQAF41 https://cassyni.com/events/C5dmR3sZpSsvkabkhQAF41/abstract https://cassyni-user-files-prod.s3.amazonaws.com/QJKZ8fBEFRCJSBhXLDZkGE https://cassyni.com/events/C5dmR3sZpSsvkabkhQAF41?videoPreview=1 Unlocking microbial activity from complex samplesnohttps://cassyni.com/events/C5dmR3sZpSsvkabkhQAF41?videoPreview=12023-01-16T12:30:00+00:00528.04Microbiome Virtual International Forum The Ribo-Zero Plus Microbiome Depletion Kit offers an RNA-to-analysis workflow solution for metatranscriptomic research. The Ribo-Zero Plus Microbiome depletion probe sets reduce unwanted rRNA reads from stool and other complex samples therefore increasing RNA reads of interest. In addition, the compli­mentary analysis software democratizes this method for both experienced and new microbiome users. The focus on analyzing high-value portions of the transcriptome allows deeper insight into active gene function in the microbiome.https://cassyni-user-files-prod.s3.amazonaws.com/QJKZ8fBEFRCJSBhXLDZkGE https://cassyni.com/slides/outline/MxbrLip4bbxFc6bnCxvcBw https://cassyni.com/events/MxbrLip4bbxFc6bnCxvcBw/abstract https://cassyni-user-files-prod.s3.amazonaws.com/KXboTaNsVLTcNSxLShiSQW https://cassyni.com/events/MxbrLip4bbxFc6bnCxvcBw?videoPreview=1 A hybrid deep learning model for optimizing particle identification systemsnohttps://cassyni.com/events/MxbrLip4bbxFc6bnCxvcBw?videoPreview=12024-08-15T12:00:00+00:002209.24Computer Physics Communications**Particle Identification (PID)** is crucial for high-energy physics (**HEP**) experiments, allowing for accurate classification of particles produced in a HEP event. Effective PID is vital for understanding fundamental physics. However, precise PID is challenging due to complex detector responses, overlapping particle signatures, and the need for efficient data processing. This presentation introduces a hybrid deep learning model specifically designed for optimizing PID systems, combining the strengths of Neural Networks (**NN**) and Random Forest (**RF**) algorithms. The traditional likelihood approach for charged particle PID, while valuable, faces limitations due to discrepancies between modeled and actual data, statistical fluctuations, and computational demands. To overcome these challenges, advanced machine learning techniques are being explored to enhance PID accuracy. A previous study, **"Optimization of the PID Algorithms at the Belle II Experiment"**, utilized **Deep Neural Networks (DNN)** and **Random Forest Regressors (RFR)** separately to optimize the PID system specifically for the Belle II Experiment. Although these models achieved promising results individually, each has its limitations: DNNs excel at capturing complex relationships but can be sensitive to noise, while RFs are robust but may struggle with intricate patterns. This presentation overviews the recent paper that combines these two models into a robust **hybrid model** using Monte Carlo simulations for a conventional HEP experiment inspired by the Belle II experiment. This approach enhances the PID system’s generalization capabilities, making it adaptable to various experimental conditions. The hybrid model leverages DNNs for feature extraction and adaptability and RFs for robustness and interpretability. This combination improves predictive performance, enhances generalization, and provides valuable insights into feature importance, resulting in a powerful and efficient PID system.https://cassyni-user-files-prod.s3.amazonaws.com/KXboTaNsVLTcNSxLShiSQW https://cassyni.com/events/QRqsa93gntijy35LkeqEus/seminar/qa https://cassyni.com/slides/outline/QRqsa93gntijy35LkeqEus https://cassyni.com/events/QRqsa93gntijy35LkeqEus/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Qhgoh8v5ALTQq1UkCBruDp https://cassyni.com/events/QRqsa93gntijy35LkeqEus?videoPreview=1 Cardio renal metabolic medicine - what is new?nohttps://cassyni.com/events/QRqsa93gntijy35LkeqEus?videoPreview=12024-10-08T08:40:00+00:001637.44North West London Kidney Caremost new treatments in CKD are having major impacts on reducing risk of CV disease, and real CV events. Managing CKD (much like diabetes) has dramatically moved into the area of broad CV disease management. Many new treatments are having a substantial impact in this area. https://cassyni-user-files-prod.s3.amazonaws.com/Qhgoh8v5ALTQq1UkCBruDp https://cassyni.com/slides/outline/H27ostLpD2RECztSCVDcTo https://cassyni.com/events/H27ostLpD2RECztSCVDcTo/abstract https://cassyni-user-files-prod.s3.amazonaws.com/U4gQuADeEyeUm8Sv3FKZBk https://cassyni.com/events/H27ostLpD2RECztSCVDcTo?videoPreview=1 Overlap integral of continuum stationary statesnohttps://cassyni.com/events/H27ostLpD2RECztSCVDcTo?videoPreview=12024-08-29T12:00:00+00:002939.28Annals of PhysicsThe rigorous formula of overlap integrals of continuum stationary states with their asymptotic expressions in potentials of finite widths are derived. Those of energies $E_1$ and $E_2$ consist of diagonal terms that are proportional to $\delta(E_1-E_2)$ and nondiagonal terms. Owing to the composition of nondiagonal terms, superpositions of stationary states have time-dependent norms and finite probability currents. These do not represent isolate states. In various exceptional potentials and in free theory, nondiagonal terms do not exist, and the superpositions of states with different energies represent isolate particles that exactly describe scattering processes. https://cassyni-user-files-prod.s3.amazonaws.com/U4gQuADeEyeUm8Sv3FKZBk https://cassyni.com/events/QvX6jTD6diCtX3QQxUCK41/abstract https://cassyni-user-files-prod.s3.amazonaws.com/DEAXetRA5RQXzM2jxseGUW https://cassyni.com/slides/outline/KVMq7JaSQKBiZwMzkB8FBj https://cassyni.com/events/KVMq7JaSQKBiZwMzkB8FBj/abstract https://cassyni-user-files-prod.s3.amazonaws.com/TesEiYZSm8YEip4Kehi1MG https://cassyni.com/events/KVMq7JaSQKBiZwMzkB8FBj?videoPreview=1 AI in Renal Pharmacynohttps://cassyni.com/events/KVMq7JaSQKBiZwMzkB8FBj?videoPreview=12024-08-21T10:45:00+00:002631.04NoneNo abstracthttps://cassyni-user-files-prod.s3.amazonaws.com/TesEiYZSm8YEip4Kehi1MG https://cassyni.com/events/XqZwGPkZNm2aTcboiXgyKs/abstract https://cassyni-user-files-prod.s3.amazonaws.com/jN9Enm2jjP7AfzXKXvPAN https://cassyni.com/slides/outline/Su5toZHJzBVZ4WtTi3yybj https://cassyni.com/events/Su5toZHJzBVZ4WtTi3yybj/abstract https://cassyni-user-files-prod.s3.amazonaws.com/CanaXuMUDhtghvG3Xw8LWi https://cassyni.com/events/Su5toZHJzBVZ4WtTi3yybj?videoPreview=1 MVIF.1 Research Highlightsnohttps://cassyni.com/events/Su5toZHJzBVZ4WtTi3yybj?videoPreview=12021-09-14T14:00:00+00:00439.04Microbiome Virtual International ForumAltered gut microbiota and metabolites are important for non-alcoholic fatty liver disease (NAFLD) in children. We aimed to comprehensively examine the effects of gut metabolites on NAFLD progression. We performed integrative metabolomics (untargeted discovery and targeted validation) analysis of non-alcoholic fatty liver (NAFL), non-alcoholic steatohepatitis (NASH), and obesity in children. Fecal samples were collected from 75 subjects in the discovery cohort (25 NAFL, 25 NASH, and 25 obese control children) and 145 subjects in an independent validation cohort (53 NAFL, 39 NASH, and 53 obese control children). Among 2,491 metabolites, untargeted metabolomics revealed a complete NAFLD metabolic map containing 318 increased and 123 decreased metabolites. Then, machine learning selected 65 important metabolites that can distinguish the severity of the NAFLD. Furthermore, precision-targeted metabolomics selected 5 novel gut metabolites from 20 typical metabolites. The functionality of candidate metabolites was validated in hepatocyte cell lines. In the end, this study annotated two novel elevated pathogenic metabolites (dodecanoic acid and creatinine) and a relationship between depleted protective gut microbiota (Butyricicoccus and Alistipes), increased inflammation (IL-1β), lipid metabolism (TG), and liver function (ALT and AST). This study demonstrates the role of novel gut metabolites (dodecanoic acid and creatinine), as the fatty acid metabolism regulator contributing to NAFLD development through its influence on inflammation and liver function. The viral community has the potential to influence the structure of the microbiome and thus the yield of the anaerobic digestion process. However, the virome composition in anaerobic digestion is still under-investigated. A viral induction experiment was conducted on separate batches undergoing a series of DNA-damaging stresses, in order to coerce temperate viruses to enter the lytic cycle. Human deep lung microbiota has been associated with lung health. Our recent study show a dynamic microbial ecosystem in lung harbouring discrete pneumotypes associated with specific immune response and clinical stability (Das, S. et al. Nat Commun 2021). But despite sharing the same niche, we know little about direct interaction between lung bacteria and human macrophages. During aging, there is a physiological decline, an increase of morbidity and mortality, and a natural change in the gut microbiome. In this study, we investigated the influence of the gut microbiome on different metabolic parameters in adult and aged mice. Background: Prenatal alcohol exposure (PAE) is one of the most preventable causes of birth defects, developmental disorders and intellectual disability, yet the prevalence of Foetal Alcohol Spectrum Disorders (FASD) in the Western Cape of South Africa is estimated to be between 16% and 31%, significantly higher than the global prevalence of 0.77%. Neurocognitive development is dependent on microbial composition and the corresponding microbial metabolic outputs. Alcohol-induced microbial alterations may alter the functioning of the infant's gut microbiota, which may therefore increase the risk of FASD development in infants. This study therefore aimed to compare the gut microbial composition of infants diagnosed with and without FASD. The biggest drawback of 16S rRNA gene sequencing is that the reads originate from a single short region and the resulting reads lack sufficient specificity for reliable species-level identification. Whole metagenomic sequencing (WMGS) is seen as a solution to this problem that should provide the highest degree of specificity. We argue that WMGS for metataxonomics can be inefficient since most parts of a typical microbial genome are non-specific and provide no value for species identification. Consequently, the sequencing budget is spent on useless parts of genomes and the process’s sensitivity is significantly reduced. This is a problem, especially in the low-abundant samples contaminated by eukaryotic DNA. Unlike WMGS, where, in theory, all organisms could be classified down to the species level, in 16S rRNA the set of identifiable species depends on a chosen primer combination.https://cassyni-user-files-prod.s3.amazonaws.com/CanaXuMUDhtghvG3Xw8LWi https://cassyni.com/slides/outline/5fCupATk7VgEvkuHqVmqSu https://cassyni.com/events/5fCupATk7VgEvkuHqVmqSu/abstract https://cassyni-user-files-prod.s3.amazonaws.com/JFGQrmSWG7iCMsTwzGjCLe https://cassyni.com/events/5fCupATk7VgEvkuHqVmqSu?videoPreview=1 Rapid and accurate identification of ribosomal RNA sequences using deep learningnohttps://cassyni.com/events/5fCupATk7VgEvkuHqVmqSu?videoPreview=12021-11-09T16:00:00+00:0067.0Microbiome Virtual International Forum Advances in transcriptomic and translatomic techniques enable in-depth studies of RNA activity profiles and RNA-based regulatory mechanisms. Ribosomal RNA (rRNA) sequences are highly abundant among cellular RNA, but if the target sequences do not include polyadenylation, these cannot be easily removed in library preparation, requiring their post-hoc removal with computational techniques to accelerate and improve downstream analyses. Here we describe RiboDetector, a novel software based on a Bi-directional Long Short-Term Memory (BiLSTM) neural network, which rapidly and accurately identifies rRNA reads from transcriptomic, metagenomic, metatranscriptomic, noncoding RNA, and ribosome profiling sequence data. Compared with state-of-the-art approaches, Ribodetector can produce one order of magnitude fewer misclassifications. Importantly, the few false positives of RiboDetector on the benchmark dataset were not enriched in certain Gene Ontology (GO) terms, suggesting a low bias for downstream functional profiling. RiboDetector also demonstrated a remarkable generalization ability for detecting novel rRNA sequences divergent from the training data with sequence identities of less than 90%. On a personal computer, RiboDetector can process 40M reads in less than 6 minutes, which is about 50 times faster in GPU mode and about 15 times in CPU mode than other methods. RiboDetector is available under a GPL v3.0 license at https://github.com/hzi-bifo/RiboDetector.https://cassyni-user-files-prod.s3.amazonaws.com/JFGQrmSWG7iCMsTwzGjCLe https://cassyni.com/slides/outline/2CfgVNw53Hobu4bjBqPsv5 https://cassyni.com/events/2CfgVNw53Hobu4bjBqPsv5/abstract https://cassyni-user-files-prod.s3.amazonaws.com/UoUqp9D3vz5TqsxBKcer3G https://cassyni.com/events/2CfgVNw53Hobu4bjBqPsv5?videoPreview=1 Simulation and modeling of high-speed gas-particle flows: insights from 18th-century cannon firings to particle-resolved simulationsnohttps://cassyni.com/events/2CfgVNw53Hobu4bjBqPsv5?videoPreview=12022-10-12T14:00:00+00:003919.04Department of Aeronautics and AstronauticsHigh-speed (compressible) flows laden with solid particles involve complex interactions between turbulence, shock waves, and a disperse phase. Examples can be found in numerous environmental and engineering applications, from volcanic eruptions to jet-induced cratering during spacecraft landings. In this talk, I will review the fluid dynamics associated with gas-particle flows under such extreme conditions. An overview of existing Mach number-dependent drag laws will be presented, with origins from 18th-century cannon fire, and new insights from particle-resolved numerical simulations. New numerical methods uniquely designed to address this class of flows will be presented, in addition to high-resolution simulations that allow us to probe turbulence and Mach number effects at the sub-particle scale and at scales that encompass millions of particles. Image credit: [Rafael Ishkhanyan (Unsplash)](https://unsplash.com/photos/a-close-up-of-a-cannon-on-a-grassy-hill-5PJMtCitQEw).https://cassyni-user-files-prod.s3.amazonaws.com/UoUqp9D3vz5TqsxBKcer3G https://cassyni.com/slides/outline/4fuhioAhEaa6G15HjXJWe1 https://cassyni.com/events/4fuhioAhEaa6G15HjXJWe1/abstract https://cassyni-user-files-prod.s3.amazonaws.com/9rPFeJ21p8wVQPFQsUqijg https://cassyni.com/events/4fuhioAhEaa6G15HjXJWe1?videoPreview=1 Different Effects of Mineral Versus Vegetal Granular Activated Carbon Filters on the Microbial Community Composition of a Drinking Water Treatment Plantnohttps://cassyni.com/events/4fuhioAhEaa6G15HjXJWe1?videoPreview=12022-03-08T16:00:00+00:0075.96Microbiome Virtual International Forum Drinking water quality and safety is strictly regulated and constantly monitored, but little is known about the microorganisms inhabiting drinking water treatment plants (DWTPs). This lack of knowledge prevents optimization of designs and operational controls. Here we investigated the drinking water microbial community harbored by a groundwater-derived DWTP, involving mineral and vegetal granular activated carbon filters (GACs). We used 16S rRNA gene sequencing to analyze water microbiome variations through the potabilization process, considering (i) different GAC materials and (ii) time from GAC regeneration. Our results revealed the predominance of Cand. Patescibacteria, uncultivable bacteria with limited metabolic capacities and small genomes, from source to downstream water. Microbial communities clustered per sampling date, with the noteworthy exception of groundwater samples. If the groundwater microbiome showed no significant variations over time, the community structure of water downstream GACs (both mineral and vegetal) seemed to be affected by time from GAC regeneration. Looking at a finer scale, different GAC material affected microbiome assembly over time with significant variation in the relative abundances of specific taxa. The significance of our research is in identifying the environmental microorganisms intrinsic of deep groundwater and the community shift after the perturbations induced by potabilization processes. Which microorganisms colonize different GACs and become abundant after GACs regeneration and over time is a first step toward advanced control of microbial communities, improving drinking water safety and management of operational costs. Link to OA paper: https://www.frontiersin.org/articles/10.3389/fevo.2021.615513/fullhttps://cassyni-user-files-prod.s3.amazonaws.com/9rPFeJ21p8wVQPFQsUqijg https://cassyni.com/slides/outline/D4vyWRAchMz5RLRkoNdZru https://cassyni.com/events/D4vyWRAchMz5RLRkoNdZru/abstract https://cassyni-user-files-prod.s3.amazonaws.com/SQ5NaZgD7cZ5x9JXpZipKg https://cassyni.com/events/D4vyWRAchMz5RLRkoNdZru?videoPreview=1 Novel high-resolution targeted sequencing of the cervicovaginal microbiomenohttps://cassyni.com/events/D4vyWRAchMz5RLRkoNdZru?videoPreview=12022-09-13T13:00:00+00:00708.04Microbiome Virtual International Forum The cervicovaginal microbiome (CVM) plays a significant role in women’s cervical health and disease. Microbial alterations at the species level and characteristic community state types (CST) have been associated with acquisition and persistence of high-risk human papillomavirus (hrHPV) infections that may result in progression of cervical lesions to malignancy. Current sequencing methods, especially most commonly used multiplex 16S rRNA gene sequencing, struggle to fully clarify these changes because they generally fail to provide sufficient taxonomic resolution to adequately perform species-level associative studies. To improve CVM species designation, we designed a novel sequencing tool targeting microbes at the species taxonomic rank and examined its potential for profiling the CVM. Results. We introduce an accessible and practical circular probe-based RNA sequencing (CiRNAseq) technology with the potential to profile and quantify the CVM. In vitro and in silico validations demonstrate that CiRNAseq can distinctively detect species in a mock mixed microbial environment, with the output data reflecting its ability to estimate microbes’ abundance. Moreover, compared to 16S rRNA gene sequencing, CiRNAseq provides equivalent results but with improved sequencing sensitivity. Analyses of a cohort of cervical smears from hrHPV-negative women versus hrHPV-positive women with high-grade cervical intraepithelial neoplasia confirmed known differences in CST occurring in the CVM of women with hrHPV-induced lesions. The technique also revealed variations in microbial diversity and abundance in the CVM of hrHPV-positive women when compared to hrHPV-negative women. Conclusions. CiRNAseq is a promising tool for studying the interplay between the CVM and hrHPV in cervical carcinogenesis. This technology could provide a better understanding of cervicovaginal CST and microbial species during health and disease, prompting the discovery of biomarkers, additional to hrHPV, that can help detect high-grade cervical lesions. Link to OA paper: https://bmcbiol.biomedcentral.com/articles/10.1186/s12915-021-01204-zhttps://cassyni-user-files-prod.s3.amazonaws.com/SQ5NaZgD7cZ5x9JXpZipKg https://cassyni.com/slides/outline/NTH5W2yUSRS5RZbJ153aN9 https://cassyni.com/events/NTH5W2yUSRS5RZbJ153aN9/abstract https://cassyni-user-files-prod.s3.amazonaws.com/6jgVMsphJjpgbshX8T6R9g https://cassyni.com/events/NTH5W2yUSRS5RZbJ153aN9?videoPreview=1 Strain-specific gene function prediction and the Human Microbiome Bioactives Resourcenohttps://cassyni.com/events/NTH5W2yUSRS5RZbJ153aN9?videoPreview=12024-03-20T12:00:00+00:001827.04Microbiome Virtual International Forum Most genetic material encountered in microbial communities - including the human microbiome - remains both uncharacterized and, often, strain-specific. This leaves a tremendous gap in translating microbiome science to personalized biomarkers and therapies. While multi-omic studies represent a promising means of prioritizing leads for validation, this still leaves thousands of molecular targets for most phenotypes of interest. The Human Microbiome Bioactives Resource (HMBR) provides a set of computational and experimental protocols for accelerating these tasks, including the identification of “bioactive” strains, microbial proteins, and chemical products from the human gut, as well as newly predicting function for uncharacterized genes and metabolites. These have proven effective in applications as diverse as the inflammatory bowel diseases (IBD, in a meta-analysis spanning over 8,700 metagenomes) or companion animal nutrition (employing almost 2,500 canine and feline gut samples). In an end-to-end example linking metagenomics, metatranscriptomics, metabolomics, inflammation phenotypes, and drug treatment, we have specifically identified a subset of microbial gene families responsible for 5-ASA inactivation, the leading cause of progression to second-line treatments in IBD. Together, this family of approaches provides multiple new avenues for identifying molecular activities responsible for microbiome-phenotype associations.https://cassyni-user-files-prod.s3.amazonaws.com/6jgVMsphJjpgbshX8T6R9g https://cassyni.com/slides/outline/NwvgYiczssz8RL8BbWLNdT https://cassyni.com/events/NwvgYiczssz8RL8BbWLNdT/abstract https://cassyni-user-files-prod.s3.amazonaws.com/HdHfs8nnJ8Tfi6XfH5pAFQ https://cassyni.com/events/NwvgYiczssz8RL8BbWLNdT?videoPreview=1 The role of the vaginal microbiome and host factors in BV recurrence after metronidazole treatmentnohttps://cassyni.com/events/NwvgYiczssz8RL8BbWLNdT?videoPreview=12024-06-11T13:00:00+00:00990.0Microbiome Virtual International Forum Bacterial vaginosis (BV) is an inflammatory condition caused by an overgrowth of anaerobic bacteria that often recurs after treatment and is associated with adverse reproductive health outcomes. Clinical criteria such as Amsel or Nugent scores are used for diagnosis, but molecular methods offer more comprehensive bacterial understanding. This six-month longitudinal study explores the relationship between vaginal microbiome, transcriptomics, and cytokine profiles to understand the interplay between host factors, the microbiome and recurrent BV inflammation after treatment.https://cassyni-user-files-prod.s3.amazonaws.com/HdHfs8nnJ8Tfi6XfH5pAFQ https://cassyni.com/slides/outline/HWo33CWE3qu42TswzbLae1 https://cassyni.com/events/HWo33CWE3qu42TswzbLae1/abstract https://cassyni-user-files-prod.s3.amazonaws.com/ATrnabPnXdWwQCXB7B7owU https://cassyni.com/events/HWo33CWE3qu42TswzbLae1?videoPreview=1 Adaptation of Anaerobic Digestion Microbial Communities to High Ammonium Levels: Insights from Strain-Resolved Metagenomicsnohttps://cassyni.com/events/HWo33CWE3qu42TswzbLae1?videoPreview=12023-11-14T10:00:00+00:0061.44Microbiome Virtual International Forum In anaerobic digestion (AD), a complex microbial community orchestrates the conversion of organic carbon into CO2 and CH4, with anaerobic archaea playing a pivotal role in methanogenesis. However, AD efficiency can be compromised by various factors, including temperature, pH, O2, salt, and ammonia concentration, with ammonia being a major culprit. Ammonia inhibition often arises when processing N-rich organic wastes, leading to potential disruptions in the digestion process. The toxicity of ammonia in AD is governed by its forms, ammonia and ammonium (NH4+), which are in equilibrium based on temperature and pH. Ammonia toxicity imposes challenges by disrupting intracellular pH and demanding additional energy. Free ammonia nitrogen can penetrate cells, interfering with essential cations and affecting metabolic reactions. Accumulated NH4+ can further destabilize intracellular pH and disrupt cation dynamics. Microbes exposed to toxic ammonia may undergo random mutations that confer a survival advantage. These adaptive mutations enable microbes to enhance their tolerance to ammonia toxicity, modifying proteins involved in stress responses. In this study, a stepwise increase in ammonia concentration up to 20 g NH4+-N/L was explored, a range not previously investigated. Genomic heterogeneity within the AD microbiome and the role of variants have received limited attention in prior research. The study introduced an innovative approach, utilizing strain-resolved metagenomics and single nucleotide variants (SNVs) to monitor microbial dynamics. This approach allowed for a comparative analysis of genetic and ecological fluctuations at both species and strain levels in response to ammonia stress. The study aimed to understand the extent to which microbial communities could adapt to ammonia stress and uncover ammonia-tolerant methanogenic consortia. The results unveiled fine-scale evolutionary mechanisms, functional dynamics, and metabolic variations within the microbial community. Specifically, the archaeon Methanoculleus bourgensis vb3066 and the putative syntrophic acetate-oxidizing bacterium Acetomicrobium sp. ma133 accumulated through generations positively selected SNVs within genes associated with stress adaptation. Additionally, the study highlighted the presence of multiple coexisting strains within species, indicating an additional layer of diversity beyond the species level. In summary, this study delves into the challenges posed by ammonia inhibition in anaerobic digestion processes. By employing advanced techniques in metagenomics and SNV analysis, it provides a comprehensive understanding of how microbial communities adapt to ammonia stress and offers insights into the selection of ammonia-tolerant microorganisms.https://cassyni-user-files-prod.s3.amazonaws.com/ATrnabPnXdWwQCXB7B7owU https://cassyni.com/slides/outline/Vs19CHgM2Hjuv97kxwuJn9 https://cassyni.com/events/Vs19CHgM2Hjuv97kxwuJn9/abstract https://cassyni-user-files-prod.s3.amazonaws.com/K7Wi9UtDe7PECbLd4yGVGJ https://cassyni.com/events/Vs19CHgM2Hjuv97kxwuJn9?videoPreview=1 Leveraging explainable AI for gut microbiome-based colorectal cancer classificationnohttps://cassyni.com/events/Vs19CHgM2Hjuv97kxwuJn9?videoPreview=12023-03-14T10:00:00+00:0068.96Microbiome Virtual International Forum Studies have shown a link between colorectal cancer (CRC) and gut microbiome compositions. In these studies, machine learning is used to infer CRC biomarkers using global explanation methods. While these methods allow the identification of bacteria generally correlated with CRC, they fail to recognize species that are only influential for some individuals. In this study, we investigate the potential of Shapley Additive Explanations (SHAP) for a more personalized CRC biomarker identification. Analyses of five independent datasets show that this method can even separate CRC subjects into subgroups with distinct CRC probabilities and bacterial biomarkers. Link to OA paper: https://doi.org/10.1186/s13059-023-02858-4https://cassyni-user-files-prod.s3.amazonaws.com/K7Wi9UtDe7PECbLd4yGVGJ https://cassyni.com/slides/outline/YLFARhuyDaWQH5bKWdowW5 https://cassyni.com/events/YLFARhuyDaWQH5bKWdowW5/abstract https://cassyni-user-files-prod.s3.amazonaws.com/WHRexC9dFMjoY4bjmL69xJ https://cassyni.com/events/YLFARhuyDaWQH5bKWdowW5?videoPreview=1 Keep the physics in the model if you can: Data assimilation in Fluid Mechanicsnohttps://cassyni.com/events/YLFARhuyDaWQH5bKWdowW5?videoPreview=12023-03-08T13:00:00+00:003286.04Department of Aeronautics and Astronautics"This talk will show one way to combine physics-based modelling with data-driven machine learning. The method assimilates data into physics-based models using Bayesian inference accelerated with adjoint methods. It quantifies the uncertainties in the model parameters and the uncertainties in the model predictions.  If the physics of the problem is known, this method is usually better than assimilating data into a Neural Network. This is because the physics-based model requires less training data, is interpretable, and extrapolates to situations that share the same physics. This framework also rigorously compares candidate physics-based models against each other, allowing the best model to be selected.  This work is inspired by David MacKay's book on information theory, inference, and learning algorithms (https://www.inference.org.uk/itprnn/book.pdf). I will present applications in Magnetic Resonance Imaging of flows (flow-MRI) and thermoacoustic oscillations in rockets and aicraft engines. An overview of the talk can be found at https://mpj1001.user.srcf.net/MJ_inference.html." Image credit: [Shahadat Rahman (Unsplash)](https://unsplash.com/photos/shallow-focus-photography-of-computer-codes-BfrQnKBulYQ).https://cassyni-user-files-prod.s3.amazonaws.com/WHRexC9dFMjoY4bjmL69xJ https://cassyni.com/slides/outline/Wr289MpXsbao87ykDEzDGq https://cassyni.com/events/Wr289MpXsbao87ykDEzDGq/abstract https://cassyni-user-files-prod.s3.amazonaws.com/LGQAhLAEibw7tkBnamtLiJ https://cassyni.com/events/Wr289MpXsbao87ykDEzDGq?videoPreview=1 A Stochastic Nonlinear Dynamical System for Smoothing Noisy Eye Gaze Datanohttps://cassyni.com/events/Wr289MpXsbao87ykDEzDGq?videoPreview=12025-06-24T10:00:00+00:00823.28NODYSIn this study, we address the challenges associated with accurately determining gaze location on a screen, which is often compromised by noise from factors such as eye tracker limitations, calibration drift, ambient lighting changes, and eye blinks. We propose the use of an extended Kalman filter (EKF) to smooth the gaze data collected during eye-tracking experiments, and systematically explore the interaction of different system parameters. Our results demonstrate that the EKF significantly reduces noise, leading to a marked improvement in tracking accuracy. Furthermore, we show that our proposed stochastic nonlinear dynamical model aligns well with real experimental data and holds promise for applications in related fields.https://cassyni-user-files-prod.s3.amazonaws.com/LGQAhLAEibw7tkBnamtLiJ https://cassyni.com/slides/outline/RQtUdqhm3ZVijFjWcKzRHP https://cassyni.com/events/RQtUdqhm3ZVijFjWcKzRHP/abstract https://cassyni-user-files-prod.s3.amazonaws.com/FCnM5xHzd2CAdiLooFcKXt https://cassyni.com/events/RQtUdqhm3ZVijFjWcKzRHP?videoPreview=1 Highly Tunable Nonlinear Bandgaps in Metamaterialsnohttps://cassyni.com/events/RQtUdqhm3ZVijFjWcKzRHP?videoPreview=12025-06-24T11:00:00+00:00615.28NODYSLocally resonant (LR) metamaterials offer significant potential for generating bandgaps and controlling elastic wave propagation. However, their nonlinear dynamic behavior remains largely unexplored experimentally. This study investigates the tunability of bandgaps in a 3D-printed spider web-like resonator metamaterial (SWRM) through laser scanning vibrometry under PZT actuation. Two samples referred to sd SWRM1 and SWRM2 were suspended and excited via PZT actuators, while velocity data were acquired using a Polytec Scanning Vibrometer PSV-500-3D. The experimental analysis identified multiple bandgaps and mapped the sequential wave transition: initially propagating in acoustic modes, interacting with bandgap regions, and subsequently emerging in optical modes. Frequency response curves (FRCs) indicate nonlinear behavior, as the bandgap widened with increasing excitation amplitude. This nonlinearity is attributed to the resonator’s geometric nonlinearity. These findings provide valuable insights into the complex dynamics of LR metamaterials, supporting further development and practical applications.https://cassyni-user-files-prod.s3.amazonaws.com/FCnM5xHzd2CAdiLooFcKXt https://cassyni.com/slides/outline/69buqBUHvhtqxfh1h2Q7bB https://cassyni.com/events/69buqBUHvhtqxfh1h2Q7bB/abstract https://cassyni-user-files-prod.s3.amazonaws.com/FhRx8dwX4UkGJhdvJnnr5U https://cassyni.com/events/69buqBUHvhtqxfh1h2Q7bB?videoPreview=1 Programmable Solitons in an Electromechanical Metamaterial Obeying the Nonlinear Schrödinger Equation via Duffing Shuntsnohttps://cassyni.com/events/69buqBUHvhtqxfh1h2Q7bB?videoPreview=12025-06-24T11:00:00+00:00754.6NODYSThe study of solitary waves in nonlinear acoustic/elastic metamaterials has garnered significant attention due to their shape-invariant properties, where dispersion and nonlinearity are perfectly balanced. Various research groups have made considerable progress in designing such metamaterials, leveraging geometric or material nonlinearities to support solitary wave propagation. Recent advances in our lab in the domain of piezoelectric structures have introduced a novel approach to incorporating nonlinearity with precise tunability and programmability: integrating piezoelectric patches connected to synthetic impedance circuits on a linear substrate or waveguide. These circuits can emulate basic linear and nonlinear electronic components —resistive, capacitive, or inductive— via digital signal processing, offering tunable and programmable characteristics. In this work, for the first time, we explore the use of synthetic impedance circuits in nonlinear metamaterials for soliton generation. We demonstrate that the dynamics of a piezoelectric metamaterial beam coupled with intentionally designed Duffing-type nonlinear shunt circuits can be described by the Nonlinear Schrödinger Equation (NLSE), a well-known model supporting envelope solitons. By adjusting the linear and nonlinear inductance values in the Duffing shunts, we achieve tunable control over both the dispersion relation and the system's nonlinearity. This allows for the initiation of solitary waves around the locally resonant bandgap and the generation of programmable solitons with either hardening or softening nonlinearity on demand. These findings may open new avenues for the development of novel programmable acoustic/elastic metamaterials with potential applications in targeted energy transfer, enhanced sensing, and physical intelligence.https://cassyni-user-files-prod.s3.amazonaws.com/FhRx8dwX4UkGJhdvJnnr5U https://cassyni.com/slides/outline/8cqw4bhv7zfLKcAaEiJkK7 https://cassyni.com/events/8cqw4bhv7zfLKcAaEiJkK7/abstract https://cassyni-user-files-prod.s3.amazonaws.com/9tp6qc66uMFALKBaEpoPTc https://cassyni.com/events/8cqw4bhv7zfLKcAaEiJkK7?videoPreview=1 Order Reduction Of Nonlinear Parametrically Excited Structural Systemsnohttps://cassyni.com/events/8cqw4bhv7zfLKcAaEiJkK7?videoPreview=12025-06-24T11:00:00+00:00734.32NODYSThe paper presents an order reduction technique for nonlinear parametrically excited structural systems. The approach is based on the concept of invariant manifolds and uses Floquet theory and a series of transformations to obtain reduced-order systems. A couple of examples are investigated, and the results obtained from the reduced-order models are compared with those of the full-order models.https://cassyni-user-files-prod.s3.amazonaws.com/9tp6qc66uMFALKBaEpoPTc https://cassyni.com/slides/outline/GXFDvAaCYgSzdegYzhHSuK https://cassyni.com/events/GXFDvAaCYgSzdegYzhHSuK/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Qw3ahVv8ToJv7Z4Rzqhfki https://cassyni.com/events/GXFDvAaCYgSzdegYzhHSuK?videoPreview=1 What in the Galaxy is Scattering Cosmic Rays?nohttps://cassyni.com/events/GXFDvAaCYgSzdegYzhHSuK?videoPreview=12025-02-06T16:00:00+00:002520.52Journal of Plasma PhysicsCosmic rays with energies << TeV affect galaxy evolution on all scales, from ionizing protoplanetary disks and molecular clouds to driving galactic outflows that alter the gas phase hundreds of kiloparsecs from the galactic disk. All models of cosmic-ray physics on “macro” scales (> pc) are sensitive to the assumed models of cosmic-ray scattering on “micro” scales (~ au), which are observationally and theoretically unconstrained. These effects are amplified in the circumgalactic medium, where models that fit existing data can vary by many orders of magnitude in their predictions for the cosmic-ray transport rate. Traditional first-principles models, which assume these magnetic fluctuations are weak and uniformly scatter CRs in a homogeneous ISM, struggle to reproduce basic observables such as the dependence of CR residence times and scattering rates on rigidity. In this talk, I will explore a new category of 'patchy' CR scattering models, wherein CRs are predominantly scattered by intermittent strong scattering structures with small volume-filling factors. These models produce the observed rigidity dependence with a simple size distribution constraint, such that larger scattering structures are rarer but can scatter a wider range of CR energies. I will present the physical properties any such structures would need to successfully scatter low-energy CRs and discuss future observational constraints that could test these models.https://cassyni-user-files-prod.s3.amazonaws.com/Qw3ahVv8ToJv7Z4Rzqhfki https://cassyni.com/slides/outline/97XADusKxp9UscVeSXfpTF https://cassyni.com/events/97XADusKxp9UscVeSXfpTF/abstract https://cassyni-user-files-prod.s3.amazonaws.com/TtwCyboH6YdYphbKyAgZJW https://cassyni.com/events/97XADusKxp9UscVeSXfpTF?videoPreview=1 Relaxation to universal non-Maxwellian equilibria in a collisionless plasmanohttps://cassyni.com/events/97XADusKxp9UscVeSXfpTF?videoPreview=12024-08-15T15:00:00+00:002421.48Journal of Plasma PhysicsThe question of how the particle distribution of a turbulent collisionless plasma will evolve, and what it may eventually relax to, is of both fundamental theoretical interest and observational consequence. In quiescent collisional plasmas, where the chaos is provided by inter-particle collisions, the answer is provided by thermodynamics and the universal maximum-entropy state is the Maxwellian distribution. However, in collisionless systems, the chaos is typically provided by the turbulent mean-field dynamics which nominally conserve an infinite set of invariants (conservation of phase volume) giving the system some memory of its initial conditions and making relaxation to a Maxwellian impossible. We will argue theoretically, and show numerically, that such plasmas will still relax towards universal equilibria, which are non-Maxwellian and feature a power-law distribution of particle energies. These equilibria will still be obtained by a maximum-entropy principle, while taking into account the conservation of these collisionless invariants on short time scales. Of course, there is no such thing as a truly collisionless system. On longer timescales these invariants are subtly broken by a turbulent cascade giving the system a kind of 'turbulent amnesia': relaxation, driven by the turbulence, to equilibrium is controlled by the collisionless invariants (the system's memory) but this memory is made imprecise by that same turbulence. We demonstrate that the invariants are driven to a universal form which results in a distribution function with a universal power-law tail in energy, with exponent -2https://cassyni-user-files-prod.s3.amazonaws.com/TtwCyboH6YdYphbKyAgZJW https://cassyni.com/slides/outline/BamBTL6xA6uyEYyCzDaTBB https://cassyni.com/events/BamBTL6xA6uyEYyCzDaTBB/abstract https://cassyni-user-files-prod.s3.amazonaws.com/NToZU5gWGWY725FK3SYw4r https://cassyni.com/events/BamBTL6xA6uyEYyCzDaTBB?videoPreview=1 A Kinetic Theory Generalization of the First Law of Thermodynamics Capturing Non-Equilibrium Effectsnohttps://cassyni.com/events/BamBTL6xA6uyEYyCzDaTBB?videoPreview=12023-05-18T15:00:00+00:003248.88Journal of Plasma PhysicsPlasmas in many settings are out of local thermodynamic equilibrium (LTE) because the time scales for collisions to achieve LTE are longer than dynamical time scales in the plasma. Examples abound in naturally occurring and laboratory plasmas - the solar corona, interplanetary space, magnetospheres of Earth and other planets, interstellar space, compact astrophysical objects, magnetically confined fusion plasmas, high energy density plasmas, and low temperature plasmas. How energy is converted in plasmas that are not in LTE is a forefront research area across the plasma sciences, and is only well-understood for small departures from LTE. However, many plasmas can be far from LTE, and therefore a non-perturbative approach is needed. The standard approach to studying energy conversion in plasmas that can be far from LTE is to investigate changes in thermal energy and the work being done that changes the density, which are both captured by the first law of thermodynamics. In this talk, we argue that this approach omits energy conversion associated with any other higher order moments of the phase space density f, and that energy conversion associated with these moments can be important for systems far from LTE. We perform a first-principles, non-perturbative, analytic theory of the energy associated with all higher order moments of f. It is based on the concept of entropy in kinetic theory and is derived from the Boltzmann equation. We use the result to calculate energy conversion in particle-in-cell simulations of collisionless two-dimensional magnetic reconnection, which reveal that energy conversion associated with higher order moments of f can be locally significant. The theoretical results may be useful in a wide array of plasma settings.https://cassyni-user-files-prod.s3.amazonaws.com/NToZU5gWGWY725FK3SYw4r https://cassyni.com/slides/outline/Pvzuj3nxXugZGhuRF95cww https://cassyni.com/events/Pvzuj3nxXugZGhuRF95cww/abstract https://cassyni-user-files-prod.s3.amazonaws.com/DydRNSziL4PYENL1jhUtEA https://cassyni.com/events/Pvzuj3nxXugZGhuRF95cww?videoPreview=1 A private path to laser-fusion energy, Focused Energy, a new startup in the fusion communitynohttps://cassyni.com/events/Pvzuj3nxXugZGhuRF95cww?videoPreview=12022-09-22T15:00:00+00:003394.92Journal of Plasma PhysicsAs clean and safe energy is needed more than ever new developments have led to the rise of startup companies around the globe taking advantage of the science developed of the years and combining the results of the past with the technology of the 21st century to make fusion energy a reality.https://cassyni-user-files-prod.s3.amazonaws.com/DydRNSziL4PYENL1jhUtEA https://cassyni.com/events/JVsGDXgBhsbUsqfBeE5pxV/abstract https://cassyni-user-files-prod.s3.amazonaws.com/HXKX1FDFsw15cyXy2xqwLi https://cassyni.com/events/JzWsGDKi9L9XscC5EfNdDo/abstract https://cassyni-user-files-prod.s3.amazonaws.com/KzZYEfSt5Dmcf8mkVkeJLv https://cassyni.com/events/VN8ZEZujMwmxQ7VDFmKWuK/abstract https://cassyni-user-files-prod.s3.amazonaws.com/EBdqghviV85qoCdyYhPvNS https://cassyni.com/slides/outline/RubKunP4HjuKNRBec6wZNV https://cassyni.com/events/RubKunP4HjuKNRBec6wZNV/abstract https://cassyni-user-files-prod.s3.amazonaws.com/LjFxGLS4cLgVfcrKbFvxa2 https://cassyni.com/events/RubKunP4HjuKNRBec6wZNV?videoPreview=1 Dusty plasma experiments: strong coupling, shocks, and testing theories of statistical physicsnohttps://cassyni.com/events/RubKunP4HjuKNRBec6wZNV?videoPreview=12022-01-13T16:00:00+00:003237.76Journal of Plasma PhysicsDusty plasmas contain small solid particles, which gain large electric charges. Typically they are micron size polymer spheres. Unlike the electron and ion components, the dust particle component tends to behave like a strongly coupled plasma, with Coulomb collisions dominating to such a degree that particles arrange themselves like atoms in a liquid or a solid. Due to their large size, the dust particles can be imaged individually in video recordings. This video imaging allows experimenters to track individual particles, which is an enormously powerful diagnostic that is unavailable in traditional plasma physics experiments, where electrons and ions cannot be imaged individually. In this talk I present, as two example research topics: shocks and tests of theories of statistical physics. While the shock topic is a traditional one for plasma physics, the topic of testing statistical physics takes the discipline of plasma physics in a new direction, by exploiting particle tracking.https://cassyni-user-files-prod.s3.amazonaws.com/LjFxGLS4cLgVfcrKbFvxa2 https://cassyni.com/events/UNqM9CcgV2fojMfD9nrC6R/abstract https://cassyni.com/events/5AMwy5D1rWe4ERjNKz2DUy/abstract https://cassyni.com/slides/outline/7dbyCVSe3oQYbNCvsfvrCu https://cassyni.com/events/7dbyCVSe3oQYbNCvsfvrCu/abstract https://cassyni-user-files-prod.s3.amazonaws.com/YLfPYBEDLmFXFuwR3NNpEz https://cassyni.com/events/7dbyCVSe3oQYbNCvsfvrCu?videoPreview=1 The role of structures and kinetic effects in astrophysical plasma turbulencenohttps://cassyni.com/events/7dbyCVSe3oQYbNCvsfvrCu?videoPreview=12023-03-23T15:00:00+00:004254.48Journal of Plasma PhysicsAstrophysical plasmas exhibit complex behavior similar to the erratic motion of turbulent viscous fluids. Despite the undeniable differences between collisionless plasmas and classical collisional fluids, there are a few (but remarkable) similarities: turbulent plasmas, like ordinary fluids, are characterized by the presence of a sea of coherent, long-living structures at which dissipation might occur. Local magnetic reconnection events, flux tubes, velocity shears, small-scale compressive layers, and so on are examples of such structures. In this talk, we will start our journey in the heliosphere by reviewing some recent (and less recent) results and focusing on the role that the above fauna of coherent patterns plays in turbulence. Since these intermittent spikes are highly correlated with local non-Maxwellian (kinetic) patterns, they could be the "hot spots" for energy conversion mechanisms in poorly-collisional systems. The end result of this interaction between coherent fields and particles is a "phase space" turbulent cascade, which has been invoked by theory, supported by simulations, and confirmed by observations. We investigate the locality of the phase space dynamics both in homogeneous turbulence as well as in the unique interaction between astrophysical shocks and turbulence, by presenting a new coarse-graining transport model. Finally, taking advantage of this experience with the heliospheric wind, we will end our trip nearby highly turbulent, supermassive black holes, demonstrating the need to model plasma accretion onto compact objects by microscopic, kinetic plasma models.https://cassyni-user-files-prod.s3.amazonaws.com/YLfPYBEDLmFXFuwR3NNpEz https://cassyni.com/slides/outline/MwNTK294sjCH8xsCu7MqpR https://cassyni.com/events/MwNTK294sjCH8xsCu7MqpR/abstract https://cassyni-user-files-prod.s3.amazonaws.com/CMdJ3j6WJiwUuFm7K59Rgi https://cassyni.com/events/MwNTK294sjCH8xsCu7MqpR?videoPreview=1 Sodium Tetradecyl Sulfate Embolization for Lymphatic Flow Disordersnohttps://cassyni.com/events/MwNTK294sjCH8xsCu7MqpR?videoPreview=12025-10-16T09:47:07+00:00920.92Society for Pediatric Interventional Radiology## Introduction Lymphatic flow disorders, including chylothorax and plastic bronchitis (PB), cause significant morbidity. Glue-based embolization is effective but carries risks of systemic embolization. Sodium tetradecyl sulfate (STS), a sclerosing agent, may provide a safer alternative with lower embolic risk and improved penetration into target lymphatic networks. This study describes initial experience with STS embolization for lymphatic flow disorders. ## Materials and Methods A review was conducted of 39 patients who underwent 42 embolization procedures with STS foam for chylothorax, PB, and genital lymphedema from April 2023 through April 2024. ## Results Among 39 patients, the primary indications were chylothorax (22/39, 56%) and PB (7/39, 18%). At a mean follow-up of 272 ± 163 days, 33/36 (92%) achieved symptom resolution, 2/36 (5.6%) improved, and 1/36 (2.8%) remained unchanged (p < 0.001). Thoracic duct patency was preserved in 31/31 (100%) cases wherein the duct was accessed for selective embolization. The most common adverse event was post-procedure pain, seen in 18/39 patients (46%). No stroke or non-target embolization occurred. The most frequently used adjunct strategies included coil embolization of the supplying pedicle in 16/42 cases (38%) and a glue plug in 14 (33%). STS was used alone without adjunctive techniques in 12/42 cases (29%). STS was injected via needle in 22/42 cases (52%). ## Discussion STS was an effective and safe agent for selective embolization of lymphatic flow disorders and may be a favorable agent for patients with high risk of systemic embolization.https://cassyni-user-files-prod.s3.amazonaws.com/CMdJ3j6WJiwUuFm7K59Rgi https://cassyni.com/slides/outline/XpqkJ2MWuNwgfCVNHmHUuj https://cassyni.com/events/XpqkJ2MWuNwgfCVNHmHUuj/abstract https://cassyni-user-files-prod.s3.amazonaws.com/BxhsxsBkv6as14aZhKxuh8 https://cassyni.com/events/XpqkJ2MWuNwgfCVNHmHUuj?videoPreview=1 The X-MESH method for capturing interfacesnohttps://cassyni.com/events/XpqkJ2MWuNwgfCVNHmHUuj?videoPreview=12022-11-21T15:00:00+00:003144.6Journal of Computational PhysicsIn this presentation, we develop an innovative approach - X-MESH - to overcome a major difficulty associated with numerical simulation in engineering: we aim to provide a revolutionary way to track physical interfaces in finite element simulations. The idea is to use so-called extreme mesh deformations. This new approach should allow low computational cost simulations as well as high robustness and accuracy. X-MESH is designed to avoid the pitfalls of current ALE methods by allowing topological changes on fixed mesh. The key idea of X-MESH is to allow elements to deform until they reach a zero measure. For example, a triangle can deform into an edge or even a point. This idea is rather extreme and completely revisits the interaction between the meshing community and the computational community, which for decades have been trying to interact through beautiful meshes. In this talk, we will focus on both the mathematical issues related to the use of zero-measure elements and the X-MESH resolution scheme. Several applications will be targeted: the Stefan model of phase change, two-phase flows and contact between deformable solids. https://cassyni-user-files-prod.s3.amazonaws.com/BxhsxsBkv6as14aZhKxuh8 https://cassyni.com/slides/outline/B52Hx6Ms1aEXpWqgdpv3C1 https://cassyni.com/events/B52Hx6Ms1aEXpWqgdpv3C1/abstract https://cassyni-user-files-prod.s3.amazonaws.com/2R67nTPmzttntqjSossJnS https://cassyni.com/events/B52Hx6Ms1aEXpWqgdpv3C1?videoPreview=1 Biophysics in Africa: Monoclonal antibodies neutralizing snake venom long & short chain three finger neurotoxinsnohttps://cassyni.com/events/B52Hx6Ms1aEXpWqgdpv3C1?videoPreview=12025-05-29T06:00:00+00:002251.64Springer Nature Physics CommunitySnakebite envenomation is a neglected tropical disease killing >135,000 people annually, predominantly in developing countries. Polyvalent antivenom is the only treatment, but it’s made through outdated technology. Monoclonal antibodies (mAbs) are the logical alternative for developing next-generation antivenom medicines. Here, we isolated a pair of antivenom mAbs that broadly cross-neutralized long and short chain three finger neurotoxins from elapids. Stored peripheral blood mononuclear cells from a hyperimmunised horse were fluorescently stained with long and short chain neurotoxins from Dendroaspis polylepis to select toxin binding memory B cells. Antibody variable genes were identified by RT-PCR and Sanger sequencing, then cloned and expressed in expiCHO. Binding was measured by ELISA and neutralization was assessed with a TE671 cell assay. Data for two crystal structures of Fab-Toxin complexes were collected at Diamond Light Source. Eight of the isolated antibodies bound snake neurotoxins and were 5%-14% mutated with human-like complementarity determining region 3 (CDR3) lengths. Two somatically related mAbs (Eq4.Dp46-3A/-3D) completely neutralized long and short chain α-neurotoxins and broadly bound neurotoxins from Africa, Asia, and the Americas. Crystal structures revealed an epitope between Fingers II and III that overlapped with the n-acetylcholine receptor (nAChR) F loop, explaining broad binding activity. Indels in heavy chain CDR1/2 were shown to determine monomeric or dimeric toxin binding, while the angle of approach completely occluded nAChR, providing a neutralization mechanism. Our data is the first to describe broadly cross-reactive mAbs with the ability to neutralise long and short chain α-neurotoxins, identifying a lead candidate for next-generation antivenom in the developing world.https://cassyni-user-files-prod.s3.amazonaws.com/2R67nTPmzttntqjSossJnS https://cassyni.com/events/5eUiqo4he7bM8LnrQjNM2m/seminar/qa https://cassyni.com/slides/outline/5eUiqo4he7bM8LnrQjNM2m https://cassyni.com/events/5eUiqo4he7bM8LnrQjNM2m/abstract https://cassyni-user-files-prod.s3.amazonaws.com/ErFgstbw7AXSw2aawp55cJ https://cassyni.com/events/5eUiqo4he7bM8LnrQjNM2m?videoPreview=1 Across the “Anzac Ocean”: New Zealand, law and protection of the word “Anzac”nohttps://cassyni.com/events/5eUiqo4he7bM8LnrQjNM2m?videoPreview=12023-04-27T23:00:00+00:005088.08SACLIn 1916, both Australia and New Zealand introduced new laws to restrict the use of a word that, only two years prior, was not yet in existence – ‘Anzac’, an informal version of the acronym referring to the Australian and New Zealand Army Corps. Following the landing of New Zealand and Australian soldiers at Gallipoli on 25 April 1915 and the events of the campaign in Turkey, the word ‘Anzac’ had taken on a special significance in both countries. The term began to be used on products, as the names of businesses and homes – with the suggestion that the Tasman Sea be renamed ‘Anzac Ocean’. This paper focuses on the New Zealand experience, examining the initial usages of this term and the government decision to intervene, on the recommendation of the Australian Government. It maps how New Zealand took a slightly softer approach than Australia, allowing for some exceptions, but also how official representations extended the protection beyond what was provided at law. The paper then considers how protection continued over the 20th century and contrasts the use of the word in New Zealand at the centenary of the Gallipoli landing in 2015 with the controversy it generated in Australia. This paper will conclude with a reflection on whether New Zealand should continue such protection into the future. Presentation file, via Tresorit: [here](https://web.tresorit.com/l/ze8iF#AQGp9BI-JAitKcVw5JAf1A) https://cassyni-user-files-prod.s3.amazonaws.com/ErFgstbw7AXSw2aawp55cJ https://cassyni.com/slides/outline/2gcigKhSQjCXv7UoZB7Mg9 https://cassyni.com/events/2gcigKhSQjCXv7UoZB7Mg9/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Dhfng7qfjqMnYUqMPYE7YA https://cassyni.com/events/2gcigKhSQjCXv7UoZB7Mg9?videoPreview=1 A landscape method to unveil high-frequency localized modes in random acoustic metamaterialsnohttps://cassyni.com/events/2gcigKhSQjCXv7UoZB7Mg9?videoPreview=12023-01-24T14:00:00+00:003351.0MetaMATMechanical media with randomly fluctuating parameters are fundamentally different from periodic (or homogeneous) media in that, above a certain threshold (and depending on dimensionality), eigenmodes are localized. While that feature may be extremely useful in practice, for any application involving vibration isolation, numerical methods currently lack for the prediction of these localized eigenmodes at a reasonable cost. Recently, the so-called localization landscape method was proposed [1] to predict such localized modes in quantum systems (Schrödinger equation). It allows to predict the locus of all the lowest localized eigenmodes by solving one single (cheap) elliptic problem. Although very elegant, this method is not useful for classical (acoustic) equations because the lower eigenmodes for this equation are de-localized and essentially hide the higher modes, which are of interest. The talk will discuss and compare the operators corresponding to the quantum and classical equations and describe a technique to use the localization landscape method with the acoustic operator.https://cassyni-user-files-prod.s3.amazonaws.com/Dhfng7qfjqMnYUqMPYE7YA https://cassyni.com/events/3BGKj1LxrBkaut1h9cQ9wT/seminar/qa https://cassyni.com/slides/outline/3BGKj1LxrBkaut1h9cQ9wT https://cassyni.com/events/3BGKj1LxrBkaut1h9cQ9wT/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Xr8ee4AgdieykozEgHrd8r https://cassyni.com/events/3BGKj1LxrBkaut1h9cQ9wT?videoPreview=1 Tunable optics with ultra-thin metasurfacesnohttps://cassyni.com/events/3BGKj1LxrBkaut1h9cQ9wT?videoPreview=12023-04-11T09:00:00+00:003757.08MetaMATOptical metasurfaces are sub-wavelength patterned surfaces that interact strongly with light. The field has been driven by the key advantages of this technology, including the ultimate miniaturization of optical elements, empowering novel functionalities that process hidden modalities of light, and the opportunity to tune their properties on demand. Several exciting applications have been demonstrated over the past years, including high-efficiency metalenses and holograms. However, many exciting new applications require metasurfaces with dynamically reconfigurable and programable functionalities. Such applications include 3D imaging, holographic displays, and light detection and ranging (LIDAR). This talk will overview the recent advances and challenges in reconfiguring optical metasurfaces. I will discuss metasurface tunability by controlling their surrounding environment and constituent elements. In particular, I will present the development of electrically driven thermo-optical metasurfaces to perform fast amplitude modulation. We demonstrate multi-pixel operation with over 70% transmission modulation. I will also discuss liquid crystal-tunable metasurfaces for full-range phase-only modulation. The presented developments aim to advance the field of tunable optical metasurface for real-world applications of active meta-optics.https://cassyni-user-files-prod.s3.amazonaws.com/Xr8ee4AgdieykozEgHrd8r https://cassyni.com/events/A6LnNaQJzbWNQh1GX3y669/seminar/qa https://cassyni.com/slides/outline/A6LnNaQJzbWNQh1GX3y669 https://cassyni.com/events/A6LnNaQJzbWNQh1GX3y669/abstract https://cassyni-user-files-prod.s3.amazonaws.com/R42ETFR1n9ZW48mgaMajJN https://cassyni.com/events/A6LnNaQJzbWNQh1GX3y669?videoPreview=1 Chronic Kidney Disease and Metabolic Diseasenohttps://cassyni.com/events/A6LnNaQJzbWNQh1GX3y669?videoPreview=12023-03-10T09:00:00+00:007416.72Dialysis GroupThe talk will cover a brief overview of CKD-MBD in young people, the severity and extent of bone disease, the effects of vascular calcification and the interplay between the two. This session will focus on dietary phosphate absorption, availability and individual variation addressed in a socio-economic and cultural context.https://cassyni-user-files-prod.s3.amazonaws.com/R42ETFR1n9ZW48mgaMajJN https://cassyni.com/slides/outline/EYZwPYSSamTRWZzk4gMM4H https://cassyni.com/events/EYZwPYSSamTRWZzk4gMM4H/abstract https://cassyni-user-files-prod.s3.amazonaws.com/EMc5qCxQfhyPwG3hMNnHLz https://cassyni.com/slides/outline/MwsfNMR28DsMogVLnCX7mo https://cassyni.com/events/MwsfNMR28DsMogVLnCX7mo/abstract https://cassyni-user-files-prod.s3.amazonaws.com/NkbnSnCstvQyG3FNab8bD8 https://cassyni.com/events/MwsfNMR28DsMogVLnCX7mo?videoPreview=1 Weisberger, J.M., Bathel, B.F. Single source/cutoff grid, self-aligned focusing schlieren systemnohttps://cassyni.com/events/MwsfNMR28DsMogVLnCX7mo?videoPreview=12021-05-10T14:00:00+00:00912.44Experiments in FluidsA compact focusing schlieren system is presented that eliminates the need for a separate source and cutoff grid. Light is projected through a grid ruling and onto a background, where it forms an image of the ruling. The light from this projected image is then reflected back onto the original grid ruling, with a polarizing prism imparting a small offset between the two. Translation of this prism along the instrument axis provides an adjustment of sensitivity of the resulting schlieren images, equivalent to the knife-edge insertion percentage of a conventional schlieren system. The manipulation of the polarization state of the light through the system allows the projected and reflected light to be coincident, maintaining a small footprint for the system, which can effectively be mounted to the front of an imaging camera. Both small-scale and large-scale systems are demonstrated, with fields-of-view ranging from tens of millimeters to approximately 500 mm-square. Because retroreflective material is used, the system is ideal for wind tunnel facilities without optical through-access, and it is demonstrated that windows have little effect on the resulting images, with only a slight reduction in image contrast observed when imaging at normal incidence to a window. The ease of construction and alignment of the system, as well as its conventional-schlieren-comparable image quality, indicates that the system could be used as a replacement of conventional systems where a focusing ability is desired.https://cassyni-user-files-prod.s3.amazonaws.com/NkbnSnCstvQyG3FNab8bD8 https://cassyni.com/slides/outline/H1PcuWwmjeLLQamzmip83f https://cassyni.com/events/H1PcuWwmjeLLQamzmip83f/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Amst5CmQFa11o4huUDWP2e https://cassyni.com/events/H1PcuWwmjeLLQamzmip83f?videoPreview=1 High-Order Mesh Generation with NekMesh + Demonohttps://cassyni.com/events/H1PcuWwmjeLLQamzmip83f?videoPreview=12022-09-14T08:30:00+00:001924.52NEKTAR++High-fidelity spectral/hp element simulations require high-order, geometry conforming curvilinear meshes. This poses a significant challenge when arbitrary geometries are considered. Therefore, we will present the main capabilities of our high-order mesh generator, NekMesh. First, we will show our main mesh generation pipeline – from CAD to valid high-quality curvilinear mesh. This will be followed by an alternative industrial pipeline suitable for very complex geometries. Last, a demonstration of this pipeline will be performed and the current work on NekMesh will be outlined.https://cassyni-user-files-prod.s3.amazonaws.com/Amst5CmQFa11o4huUDWP2e https://cassyni.com/slides/outline/KUde8wBPvw6pmXFZKQikmb https://cassyni.com/events/KUde8wBPvw6pmXFZKQikmb/abstract https://cassyni-user-files-prod.s3.amazonaws.com/FeQHtfSXZhUbcoDg8QUZwU https://cassyni.com/events/KUde8wBPvw6pmXFZKQikmb?videoPreview=1 Carbon Molecular Sieve Membranes for Advanced Separationsnohttps://cassyni.com/events/KUde8wBPvw6pmXFZKQikmb?videoPreview=12022-11-02T09:00:00+00:003398.64ElsevierMolecular separation processes are essential in the production of clean water, pharmaceuticals, commodity and specialty chemicals, and fuels. 40-60% of the energy used in the production of these materials is spent on separation and purification processes, which amounts to approximately 10-15% of the worldwide energy consumption. In downstream chemical processes, selective removal of high-valued chemicals is required for the production of synthetic fibers, solvents, and films and is currently performed using energy-intensive techniques such as distillation, crystallization, and absorption etc... Membrane-based processes have strong potential to further reduce the energy intensity of chemical separations when advanced functional materials are integrated with the scalable membrane platform. In this talk, molecularly-selective membranes derived from carbon molecular sieve (CMS) will be presented. These membranes have shown excellent chemical resistance, high molecular selectivity, and fast mass transport across the membrane that surpasses the “polymer upper bound trade-off line” for many molecular pairs. Organic solvent separations via forward osmosis will be covered by CMS hollow fiber membranes. Gas separation (C2H4/C2H6 and H2/CO2) will be covered electron-mediated CMS membranes.https://cassyni-user-files-prod.s3.amazonaws.com/FeQHtfSXZhUbcoDg8QUZwU https://cassyni.com/slides/outline/E3tiEEH2jwybh71EGaENt5 https://cassyni.com/events/E3tiEEH2jwybh71EGaENt5/abstract https://cassyni-user-files-prod.s3.amazonaws.com/8rmRowquKteQsLB8KfE9AE https://cassyni.com/events/E3tiEEH2jwybh71EGaENt5?videoPreview=1 Morphology matters, or Do you need to teach affixes?nohttps://cassyni.com/events/E3tiEEH2jwybh71EGaENt5?videoPreview=12022-11-04T03:00:00+00:003066.12Linguistics and Applied Language StudiesThe presented research investigates the role of morphological complexity (with the focus on derived forms, e.g. 'player' rather than inflected ones, e.g. 'plays', in academic writing through the analysis of written work produced by ten students over the course of their EAP studies in IPU New Zealand. The study is aimed at analyzing the relationship between the accurate use of morphologically complex vocabulary in students' written assessments and the grades that they received for their work. The quantitative analysis indicates that there is a relation between the grade and morphological derivational complexity. The qualitative analysis of individual students’ work further explores the noted trends to investigate what types of complex words are most commonly used at different levels of language proficiency. The analysis is based on Bauer and Nation’s (1993) system of seven word-family levels to establish the appropriate expectations with regard to the level of morphological awareness for learners who are preparing for undergraduate study. The results of the analysis can be used as the basis of recommendations to EAP practitioners and EAP curriculum developers. https://cassyni-user-files-prod.s3.amazonaws.com/8rmRowquKteQsLB8KfE9AE https://cassyni.com/slides/outline/2BwVX1Y2Zuii6eVHm4zPVw https://cassyni.com/events/2BwVX1Y2Zuii6eVHm4zPVw/abstract https://cassyni-user-files-prod.s3.amazonaws.com/NUHkLSuyVgPMBzsTg7PmyG https://cassyni.com/events/2BwVX1Y2Zuii6eVHm4zPVw?videoPreview=1 A procedure for computing the spot production rate in transitional boundary layers, Large field Digital Image Plane Holography with a double cavity high speed lasernohttps://cassyni.com/events/2BwVX1Y2Zuii6eVHm4zPVw?videoPreview=12022-11-22T15:00:00+00:002867.08Experiments in FluidsThe present work describes a method for the computation of the nucleation rate of turbulent spots in transitional boundary layers from particle image velocimetry (PIV) measurements. Different detection functions for turbulent events recognition were first tested and validated using data from direct numerical simulation, and this latter describes a flat-plate boundary layer under zero pressure gradient. The comparison with a previously defined function adopted in the literature, which is based on the local spanwise wall-shear stress, clearly highlights the possibility of accurately predicting the statistical evolution of transition even when the near-wall velocity field is not directly available from the measurements. The present procedure was systematically applied to PIV data collected in a wall-parallel measuring plane located inside a flat plate boundary layer evolving under variable Reynolds number, adverse pressure gradient (APG) and free-stream turbulence. The results presented in this work show that the present method allows capturing the statistical response of the transition process to the modification of the inlet flow conditions. The location of the maximum spot nucleation is shown to move upstream when increasing all the main flow parameters. Additionally, the transition region becomes shorter for higher Re and APG, whereas the turbulence level variation gives the opposite trend. The effects of the main flow parameters on the coefficients defining the analytic distribution of the nucleation rate and their link to the momentum thickness Reynolds number at the point of transition are discussed in the paper. The three velocity components in a fluid plane can be measured by applying Digital Image Plane Holography. This technique is limited by the laser coherence length, which reduces its application with high speed lasers that, generally, have a very short coherence length. In addition, the use of a double cavity can also imply a small wavelength difference between the two laser beams. In this work, we present an improved Optical Path Length Enlarging Device that allows the velocity measurement, in a 2D field whose width is four times larger than the laser coherence length. The optical set-up and the procedure for measuring in a larger field (ten times the laser coherence length) were optimized, and the issues derived from the laser spatial and temporal coherence and wavelength changes were analyzed and solved. Digital Image Plane Holography with the Optical Path Length Enlarging Device and Particle Image Velocimetry were applied for measuring the whole velocity field in the central plane of a cylindrical cavity with a rotating lid, for two Reynolds numbers (800 and 2000), showing both of them a very good agreement with the numerical simulations.https://cassyni-user-files-prod.s3.amazonaws.com/NUHkLSuyVgPMBzsTg7PmyG https://cassyni.com/slides/outline/4fBWkRmemCVCTaxrJku2Ds https://cassyni.com/events/4fBWkRmemCVCTaxrJku2Ds/abstract https://cassyni-user-files-prod.s3.amazonaws.com/MLuQBT5fqGhQC3u8w5iT4a https://cassyni.com/events/4fBWkRmemCVCTaxrJku2Ds?videoPreview=1 On a toroidal method to solve the sessile drop oscillation problemnohttps://cassyni.com/events/4fBWkRmemCVCTaxrJku2Ds?videoPreview=12021-04-30T15:00:00+00:001812.0Journal of Fluid MechanicsThe natural oscillation of a drop is a classical fluid mechanics problem. Analytical expressions for the simple case of free, spherical drops were obtained by Rayleigh, Lamb, Chandrasekhar and others using spherical coordinate system. In recent times, the focus on this problem has shifted towards a sessile drop supported on a flat substrate, as evident through some recent works. The majority of these are computational in nature. In this talk, I will present an alternative new mathematical framework, the toroidal coordinate system, to solve this long-standing problem analytically for small drops (Bond number << 1) with pinned contact lines. I start with the governing hydrodynamic equations and boundary conditions, write them in terms of the toroidal coordinate system and then obtain solutions by reducing them to an eigenmode problem. Resonant frequencies are identified for zonal, sectoral and tesseral vibration modes and compared with results presented in the literature and by other models. The impact of viscous dissipation in the bulk liquid, at the contact line, and contact line mobility is discussed qualitatively. I conclude with a discussion of the importance of conformal mapping for solving axisymmetric physical problems with complicated geometries.https://cassyni-user-files-prod.s3.amazonaws.com/MLuQBT5fqGhQC3u8w5iT4a https://cassyni.com/slides/outline/D4CnY3maDyuBcvKKNcE5Sm https://cassyni.com/events/D4CnY3maDyuBcvKKNcE5Sm/abstract https://cassyni-user-files-prod.s3.amazonaws.com/GQTBEFUEskU2L4oJ52whMx https://cassyni.com/slides/outline/FXSomU1CRGffyrnsvJ8iAh https://cassyni.com/events/FXSomU1CRGffyrnsvJ8iAh/abstract https://cassyni-user-files-prod.s3.amazonaws.com/7rLdSY6YZLwNnNMSTymuGA https://cassyni.com/events/FXSomU1CRGffyrnsvJ8iAh?videoPreview=1 Amazing Structures of Optimal Multicomponent Compositesnohttps://cassyni.com/events/FXSomU1CRGffyrnsvJ8iAh?videoPreview=12022-07-05T16:00:00+00:001245.04ETOPIMThe paper describes a method for bounds of effective properties. The fields in optimal composite structures are piece-wise constant, but the structures may be fractal. We complement the translation method for the bounds by inequalities restricting the range of fields and resulting in exact bounds for multi-material composites.https://cassyni-user-files-prod.s3.amazonaws.com/7rLdSY6YZLwNnNMSTymuGA https://cassyni.com/slides/outline/C4uaSgUXM4o2xAVKGdkkds https://cassyni.com/events/C4uaSgUXM4o2xAVKGdkkds/abstract https://cassyni-user-files-prod.s3.amazonaws.com/77NDsWdFuA7EGtQmhg17Sn https://cassyni.com/events/C4uaSgUXM4o2xAVKGdkkds?videoPreview=1 Photonic Time-Crystalsnohttps://cassyni.com/events/C4uaSgUXM4o2xAVKGdkkds?videoPreview=12022-07-07T15:00:00+00:002792.04ETOPIMPhotonic Time Crystals (PTCs) are dielectric media whose refractive index is modulated periodically in time at time-scales of an optical cycle. These systems conserve momentum but not energy, and are characterized by momentum bands and bandgaps, where the amplitudes of their eigenmodes can increase (or decrease) exponentially. I will introduce the fundamentals of PTCs, discuss the topological features of waves propagating in PTCs, localization in PTCs containing disorder, and spatiotemporal photonic crystals. But more interesting than all the rest - I will discuss the classical and quantum features of light emission in PTCs from various radiation sources, such as free electrons, classical dipoles, quantum fluctuations, and the emission by atoms. The latter opens new avenues for making widely tunable lasers that extract energy from the temporal modulation of the medium.https://cassyni-user-files-prod.s3.amazonaws.com/77NDsWdFuA7EGtQmhg17Sn https://cassyni.com/slides/outline/NSYtXfaRy3MBd9UraJe5x1 https://cassyni.com/events/NSYtXfaRy3MBd9UraJe5x1/abstract https://cassyni-user-files-prod.s3.amazonaws.com/7xQgwFRd9NVJ9Ueq8XTZi6 https://cassyni.com/events/NSYtXfaRy3MBd9UraJe5x1?videoPreview=1 Surgical planning for coronary artery bypass operations using patient-specific computational fluid dynamics modellingnohttps://cassyni.com/events/NSYtXfaRy3MBd9UraJe5x1?videoPreview=12022-11-15T03:00:00+00:004575.04The Auckland Bioengineering InstituteCoronary artery disease is the leading cause of mortality and morbidity worldwide. Coronary artery bypass grafting operations have been performed as a treatment for this disease for over 60 years. There has been recent interest in the exclusive use of arterial grafts as conduits for this operation, in particular bilateral internal mammary arteries, on account of their longevity. However, there still exists significant variability in grafting strategy amongst cardiac surgeons and there remains controversy as to the optimal grafting configuration for a given patient. This is due to the complexity of the biophysics of a particular individual’s coronary circulation and the resulting degree of uncertainty facing a surgeon. The overall aim of this research was to investigate whether predictive patient-specific computational modelling could aid cardiac surgeons in their selection of grafting configurations using bilateral internal mammary and radial arteries for patients with severe triple vessel disease. In particular, the purpose was to avoid the selection of unsatisfactory grafting configurations that would result in grafts with limited patency due to flow competition. This study was conducted by recruiting 16 cardiac surgeons (8 experts and 8 novices). Surgeons selected their preferred grafting configuration for each of 5 patients, including an anaortic technique which could be performed without the need for cardiopulmonary bypass. Five patient-specific 1D-0D lumped parameter computational models were created to compare 12 total arterial grafting configurations used internationally. The hemodynamic predictions included mean graft flow, pulsatility index and degree of regional myocardial perfusion restored. Surgeons then selected their preferred grafting configurations after viewing the computational data. The use of computational models led to a significant decrease in the selection of unsatisfactory grafting configurations using anaortic techniques. It also resulted in more patient-specific tailoring of individual grafting configurations for these techniques. Computer modelling informed novices were more likely to choose optimal grafting configurations whereas experts were content with satisfactory grafting configurations. Novices were also more likely than experts to be influenced by the computer model in selecting grafting configurations that they would usually avoid the use of. The 1D-0D predictive patient-specific models demonstrated that the arterial grafting configurations using composite and sequential grafts are patient-specific. Based on these results it is concluded that grafting configurations should be adjusted specifically for each patient. The use of computer modelling can aid surgeons in making better decisions for patients particularly in the context of more technically challenging anaortic operations that use bilateral internal mammary and radial arteries in patients with triple vessel disease. https://cassyni-user-files-prod.s3.amazonaws.com/7xQgwFRd9NVJ9Ueq8XTZi6 https://cassyni.com/slides/outline/NwCVaMDxQVuEcv1kAjvtDK https://cassyni.com/events/NwCVaMDxQVuEcv1kAjvtDK/abstract https://cassyni-user-files-prod.s3.amazonaws.com/PCLR71ktUjmmTkkoqr9Rc2 https://cassyni.com/events/NwCVaMDxQVuEcv1kAjvtDK?videoPreview=1 X-Waves and Modulation Instabilitynohttps://cassyni.com/events/NwCVaMDxQVuEcv1kAjvtDK?videoPreview=12020-11-27T16:40:00+00:001381.8Journal of Fluid MechanicsModulation instability is characterised by a rapid transfer of energy from a dominant central frequency to sideband frequencies. Dispersive media such as water, optics, and Bose-Einstein condensate, all allow for modulation instability. In the space-time domain, modulation instability manifests itself as a single extreme wave crest arising from an initially periodic, constant amplitude wavetrain. Given the sudden appearance of an unexpectedly high wave crest, the modulation instability has long been proposed as a mechanism by which extreme ocean waves are formed. In this talk I will present the experimental work performed with various collaborators in both the University of Edinburgh’s circular basin (FloWave) and University College London’s combined wave-current flume. In the FloWave basin we observed the propagation of a nondispersive X-wave,a wave structure capable of transporting an extremely large wave at its centre over vast distances without dispersing. The X-wave was predicted using the three-dimensional nonlinear Schrödinger equation (NLSE) to balance nonlinear, dispersive, and diffractive wave properties. At University College London we showed experimentally how a linear vertically sheared current reduces the growth rate of modulation instability as predicted by a modified version of the NLSE, the constant vorticity NLSE (vor-NLSE).At University College London we showed experimentally how a linear vertically sheared current reduces the growth rate of modulation instability as predicted by a modified version of the NLSE, the constant vorticity NLSE (vor-NLSE).At University College London we showed experimentally how a linear vertically sheared current reduces the growth rate of modulation instability as predicted by a modified version of the NLSE, the constant vorticity NLSE (vor-NLSE).https://cassyni-user-files-prod.s3.amazonaws.com/PCLR71ktUjmmTkkoqr9Rc2 https://cassyni.com/events/HW4r4q7BaTpAE3mWZpw6Ds/abstract https://cassyni-user-files-prod.s3.amazonaws.com/NbhkdHTqEHrutoMkLY8jEW https://cassyni.com/slides/outline/YKWyTLWvkCRWUfUt5sQT5w https://cassyni.com/events/YKWyTLWvkCRWUfUt5sQT5w/abstract https://cassyni-user-files-prod.s3.amazonaws.com/4t94PfjaoWzVSEYdkZtG1k https://cassyni.com/events/YKWyTLWvkCRWUfUt5sQT5w?videoPreview=1 Some Ideas for Future Algorithms for Multidisciplinary Analysis and Optimization: Nonlinear Stability, Algorithm Optimization, and Monolithic Methodsnohttps://cassyni.com/events/YKWyTLWvkCRWUfUt5sQT5w?videoPreview=12022-12-09T02:00:00+00:003351.52Mechanical EngineeringIn this presentation, three topics that have the potential to contribute to next-generation algorithms for single- and multi-disciplinary analysis and optimization will be covered. These include 1) entropy stable methods applicable to simplices and hence unstructured grids, 2) the use of numerical optimization in the design of algorithms, and 3) monolithic methods for multi-physics and optimization.https://cassyni-user-files-prod.s3.amazonaws.com/4t94PfjaoWzVSEYdkZtG1k https://cassyni.com/slides/outline/TP2vzW3gMctV5ZmY5PhTMo https://cassyni.com/events/TP2vzW3gMctV5ZmY5PhTMo/abstract https://cassyni-user-files-prod.s3.amazonaws.com/TozdsmPe4ZkMyyDow9z4M4 https://cassyni.com/events/TP2vzW3gMctV5ZmY5PhTMo?videoPreview=1 Learning and Learning to Solve PDEsnohttps://cassyni.com/events/TP2vzW3gMctV5ZmY5PhTMo?videoPreview=12022-01-12T09:00:00+00:003101.0DataSıgDeep learning continues to dominate machine learning and has been successful in computer vision, natural language processing, etc. Its impact has now expanded to many research areas in science and engineering. In this talk, I will mainly focus on some recent impacts of deep learning on computational mathematics. I will present our recent work on bridging deep neural networks with numerical differential equations, and how it may guide us in designing new models and algorithms for some scientific computing tasks. On the one hand, I will present some of our works on the design of interpretable data-driven models for system identification and model reduction. On the other hand, I will present our recent attempts at combining wisdom from numerical PDEs and machine learning to design data-driven solvers for PDEs and their applications in electromagnetic simulation.https://cassyni-user-files-prod.s3.amazonaws.com/TozdsmPe4ZkMyyDow9z4M4 https://cassyni.com/slides/outline/DYt1hMvz4oP1SPJqAiM3cy https://cassyni.com/events/DYt1hMvz4oP1SPJqAiM3cy/abstract https://cassyni-user-files-prod.s3.amazonaws.com/NFhb75Mz8AWtm6Z1t3ZJUW https://cassyni.com/events/DYt1hMvz4oP1SPJqAiM3cy?videoPreview=1 Path signatures in topology, dynamics and data analysisnohttps://cassyni.com/events/DYt1hMvz4oP1SPJqAiM3cy?videoPreview=12020-08-06T16:00:00+00:002268.16DataSıgThe signature of a path in Euclidean space resides in the tensor algebra of that space; it is obtained by systematic iterated integration of the components of the given path against one another. This straightforward definition conceals a host of deep theoretical properties and impressive practical consequences. In this talk I will describe the homotopical origins of path signatures, their subsequent application to stochastic analysis, and how they facilitate efficient machine learning in topological data analysis. This last bit is joint work with Ilya Chevyrev and Harald Oberhauser.https://cassyni-user-files-prod.s3.amazonaws.com/NFhb75Mz8AWtm6Z1t3ZJUW https://cassyni.com/events/8cZhvJZ46PQ4s8nQLsXfE5/seminar/qa https://cassyni.com/slides/outline/8cZhvJZ46PQ4s8nQLsXfE5 https://cassyni.com/events/8cZhvJZ46PQ4s8nQLsXfE5/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Px96wbH6WtA5tARmNNXgzS https://cassyni.com/events/8cZhvJZ46PQ4s8nQLsXfE5?videoPreview=1 Rising Stars in Organic Synthesis, Session 3nohttps://cassyni.com/events/8cZhvJZ46PQ4s8nQLsXfE5?videoPreview=12024-04-24T16:00:00+00:007850.96Thieme GroupThe Science of Synthesis Early Career Board (ECAB), established in 2022, and the Thieme Chemistry Journal Awards recognize some of the most up-and-coming young organic chemists. We are very proud to present both ECAB members and journal award winners as speakers in this Rising Stars Cheminar.https://cassyni-user-files-prod.s3.amazonaws.com/Px96wbH6WtA5tARmNNXgzS https://cassyni.com/slides/outline/F2uhBJRDbFpUu5sDWsKHNm https://cassyni.com/events/F2uhBJRDbFpUu5sDWsKHNm/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Hzo6EcuqgF55kVRynDwwy8 https://cassyni.com/events/F2uhBJRDbFpUu5sDWsKHNm?videoPreview=1 Spreading of yield stress fluidsnohttps://cassyni.com/events/F2uhBJRDbFpUu5sDWsKHNm?videoPreview=12023-10-06T15:00:00+00:003401.4Journal of Fluid MechanicsThe spreading of complex fluids is essential in many industrial processes for example in the cosmetic industry. We study here the spreading of complex fluids in two different geometries: dip coating experiments where a rod is pulled out of a yield stress fluid and soft blade experiments where a coating film is obtained by squeezing a liquid drop with a soft elastic blade. In the dip coating experiment with a yield-stress fluid, we show that the thickness of the coating film does not follow the classical Landau-Levich theory which is based on the drainng of the film. Rather the thickness of the film is limited by the hydrodynamics of the bulk reservoir. We propose scaling laws for the film thickness and discuss the cross over between thes two possible behaviors. In the soft blade experiment we first study simple non-newtonian fluids an show the importance of the wetting length, which measures the ize of the blade a the tip wetted by the fluid. We then generalize our study to shear-thinning and normal stress fluids. https://cassyni-user-files-prod.s3.amazonaws.com/Hzo6EcuqgF55kVRynDwwy8 https://cassyni.com/events/TPm7xsSipzyNsysyWA6wmw/seminar/qa https://cassyni.com/slides/outline/TPm7xsSipzyNsysyWA6wmw https://cassyni.com/events/TPm7xsSipzyNsysyWA6wmw/abstract https://cassyni-user-files-prod.s3.amazonaws.com/75eWFfauPA67yz8id8zS3G https://cassyni.com/events/TPm7xsSipzyNsysyWA6wmw?videoPreview=1 Learning to Read Facial Expressionsnohttps://cassyni.com/events/TPm7xsSipzyNsysyWA6wmw?videoPreview=12024-10-09T12:00:00+00:003254.04Journal on Image and Video ProcessingThe field of facial behavior analysis stands at the forefront of advancing intelligent systems, with applications that span clinical diagnostics, mental health assessment, customer service optimization, strategic business negotiations, and law enforcement. At the heart of this domain is the nuanced study of facial expressions, particularly micro-expressions, which are fleeting and subtle in nature, often lasting no more than half a second and characterized by minimal but significant facial movements. This research talk will delve into the intricacies of deciphering facial expressions, highlighting the complexities associated with micro-expressions due to their ephemeral nature and the low-amplitude facial cues they present. We will present our latest findings and methodologies that aim to enhance the accuracy and sensitivity of expression recognition technologies.https://cassyni-user-files-prod.s3.amazonaws.com/75eWFfauPA67yz8id8zS3G https://cassyni.com/events/3BzWhNk1KZqUiJ88aNoeMb/seminar/qa https://cassyni.com/slides/outline/3BzWhNk1KZqUiJ88aNoeMb https://cassyni.com/events/3BzWhNk1KZqUiJ88aNoeMb/abstract https://cassyni-user-files-prod.s3.amazonaws.com/XTPZoK6rPpToqYhbZtWV34 https://cassyni.com/events/3BzWhNk1KZqUiJ88aNoeMb?videoPreview=1 Rule-Elimination Theorems, ExtenDD. Coming to Terms: Proof Theory Extended to Definite Descriptions and other Termsnohttps://cassyni.com/events/3BzWhNk1KZqUiJ88aNoeMb?videoPreview=12024-09-25T14:00:00+00:004507.48Logica UniversalisCut-elimination theorems constitute one of the most important classes of theorems of proof theory. Since Gentzen’s proof of the cut-elimination theorem for the system LK, several other proofs have been proposed. Even though the techniques of these proofs can be modified to sequent systems other than LK, they are essentially of a very particular nature; each of them describes an algorithm to transform a given proof to a cut-free proof. However, due to its reliance on heavy syntactic arguments and case distinctions, such an algorithm makes the fundamental structure of the argument rather opaque . We, therefore, consider rules abstractly, within the framework of logical structures familiar from universal logic and aim to clarify the essence of the so-called “elimination theorems”. To do this, we first give a non-algorithmic proof of the cut-elimination theorem for the propositional fragment of LK. From this proof, we abstract the essential features of the argument and define something called normal sequent structures relative to a particular rule. We then prove a version of the rule-elimination theorem for these. Abstracting even more, we define abstract sequent structures and show that for these structures, the corresponding version of the rule-elimination theorem has a converse as well. https://cassyni-user-files-prod.s3.amazonaws.com/XTPZoK6rPpToqYhbZtWV34 https://cassyni.com/slides/outline/Kz4gPFFjeVbKDQPyhngiW1 https://cassyni.com/events/Kz4gPFFjeVbKDQPyhngiW1/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Kdm9CA6tHG1rRpW2FAshzv https://cassyni.com/events/Kz4gPFFjeVbKDQPyhngiW1?videoPreview=1 1.2 The Economic Context: ScholComm is Moneynohttps://cassyni.com/events/Kz4gPFFjeVbKDQPyhngiW1?videoPreview=12024-10-25T16:00:00+00:003419.44Medical Library Association’s Scholarly Communications CaucusEngage with a panel discussion on private, academic, and self-publishing in scholarly communication, and the economic challenges across disciplines.https://cassyni-user-files-prod.s3.amazonaws.com/Kdm9CA6tHG1rRpW2FAshzv https://cassyni.com/events/UsmBLBR4x6V8CCjxZk8ju7/seminar/qa https://cassyni.com/slides/outline/UsmBLBR4x6V8CCjxZk8ju7 https://cassyni.com/events/UsmBLBR4x6V8CCjxZk8ju7/abstract https://cassyni-user-files-prod.s3.amazonaws.com/7KyJn1QfbtNApUnGsuahK4 https://cassyni.com/events/UsmBLBR4x6V8CCjxZk8ju7?videoPreview=1 ColorVideoVDP - how low-level human vision models help to design better quality metricsnohttps://cassyni.com/events/UsmBLBR4x6V8CCjxZk8ju7?videoPreview=12025-01-09T13:00:00+00:003285.04Journal on Image and Video ProcessingThe dominant image and video quality metrics rarely consider the physical specification of video content (luminance, frame rate, resolution) or incorporate models of human vision. In this talk, I will show how a robust video quality metric can be built from fundamental models of low-level human vision and how such a metric can generalize to any display specification (size, resolution, dynamic range) and viewing conditions (ambient light, viewing distance). I will explain how we built a model of contrast sensitivity for achromatic and chromatic spatiotemporal patterns (castleCSF) and combined it with a contrast masking model to create our new video quality metric - ColorVideoVDP. ColorVideoVDP brings many advantages, such as explainability, robustness to unseen distortions, differentiable formulation, and the ability to adapt to the physical characteristics of the content (frame rate, HDR/SDR colour spaces). https://cassyni-user-files-prod.s3.amazonaws.com/7KyJn1QfbtNApUnGsuahK4 https://cassyni.com/events/TtTyEp825BNyXSuxTmfR6D/seminar/qa https://cassyni.com/slides/outline/TtTyEp825BNyXSuxTmfR6D https://cassyni.com/events/TtTyEp825BNyXSuxTmfR6D/abstract https://cassyni-user-files-prod.s3.amazonaws.com/4jhENWdH8g6maQeeRW1kgn https://cassyni.com/events/TtTyEp825BNyXSuxTmfR6D?videoPreview=1 Wave engineering in programmable piezoelectric metamaterials with digital shuntsnohttps://cassyni.com/events/TtTyEp825BNyXSuxTmfR6D?videoPreview=12025-01-14T14:00:00+00:004605.04MetaMATThis talk will review our recent and ongoing efforts on programmable piezoelectric metamaterials that exploit synthetic impedance circuits, eliminating not only the need for mechanical (manual) reconfiguration but also bulky analog circuit components used in prior efforts. The examples of piezoelectric metamaterials we will discuss span from digital programming of directional bandgap formation to tunable wave mode conversion. In all cases, the piezoelectric unit cells are shunted to separate synthetic impedance circuits that act as voltage-controlled current sources employing a digital filter. Following a generalized electromechanical framework of piezoelectric metamaterials for arbitrary shunt admittance, we will first review locally resonant bandgap formation and its tuning over a broad frequency range. Then, we will discuss spatial modulation of circuit impedance especially for gradient concepts such as the rainbow phenomenon and the acoustic/elastic black hole. These concepts also employ resonant unit cells, and we will explore various spatial profiles of synthetic shunt inductance distribution for wave localization and compression, along with multifunctional implementations such as concurrent energy harvesting from the trapped/localized modes. Spatial modulation will be followed by spatiotemporal modulation, with some of the first locally resonant piezoelectric metamaterial case studies with reciprocity breaking. Unlike the existing counterparts with analog switching circuits on capacitive shunts, we use smooth parameter variation and inductive shunts, providing additional (resonant) tunability to create directional bandgaps. Topologically protected counterparts will also be shown, as well as Rayleigh-to-shear wave mode conversion and double-negative refractive index scenarios enabled by resonant shunts. We will then discuss further programmable examples including exceptional points (via degeneracy introduced electrically) using a waveguide with piezoelectric elements having a balanced gain and loss. Nonlinear synthetic impedance implementations will also be demonstrated for Duffing-type (hardening or softening) shunts, specifically for solitary wave generation as part of our ongoing work with waveguides obeying the nonlinear Schrödinger equation form. https://cassyni-user-files-prod.s3.amazonaws.com/4jhENWdH8g6maQeeRW1kgn https://cassyni.com/slides/outline/6eazFRJTCVZfPgvnbDTGwP https://cassyni.com/events/6eazFRJTCVZfPgvnbDTGwP/abstract https://cassyni-user-files-prod.s3.amazonaws.com/JQ5qQcBsD6p9VwyYERE7sC https://cassyni.com/events/6eazFRJTCVZfPgvnbDTGwP?videoPreview=1 Visual cortex anodal transcranial direct current stimulation does not alter reading performance for Chinese presented character-by-character to normal peripheral vision in older adultsnohttps://cassyni.com/events/6eazFRJTCVZfPgvnbDTGwP?videoPreview=12025-01-13T08:00:00+00:001018.8Frontiers in NeuroscienceVisual cortex anodal transcranial direct current stimulation (a-tDCS) has been shown to reduce crowding in normal peripheral vision and may improve the reading of English words in patients with macular degeneration. Given the different visual requirements of reading English words and Chinese characters, the effect of a-tDCS on peripheral reading performance in English might differ from Chinese. This study recruited 20 participants (59–73 years of age) with normal vision and tested the hypothesis that a-tDCS would improve the reading of Chinese characters presented at 10° eccentricity compared with sham stimulation. Chinese sentences of different print sizes and exposure durations were presented one character at a time, 10° below or to the left of fixation. The individual critical print size (CPS) – the smallest print size eliciting the maximum reading speed (MRS) – was determined. Reading accuracies for characters presented 0.2 logMAR smaller than the individually fitted CPS were measured at four time points: before, during, 5 min after, and 30 min after receiving active or sham visual cortex a-tDCS. Participants completed both the active and sham sessions in a random order following a double-blind, within-subject design. No effect of active a-tDCS on reading accuracy was observed, implying that a single session of a-tDCS did not improve Chinese character reading in normal peripheral vision. This may suggest that a-tDCS does not significantly reduce the crowding elicited within a single Chinese character. However, the effect of a-tDCS on between-character crowding is yet to be determined.https://cassyni-user-files-prod.s3.amazonaws.com/JQ5qQcBsD6p9VwyYERE7sC https://cassyni.com/events/i6wnaqCov2dzbDSajkHDF/seminar/qa https://cassyni.com/slides/outline/i6wnaqCov2dzbDSajkHDF https://cassyni.com/events/i6wnaqCov2dzbDSajkHDF/abstract https://cassyni-user-files-prod.s3.amazonaws.com/P4cypZ7MxSq9uwSSP6ooYa https://cassyni.com/events/i6wnaqCov2dzbDSajkHDF?videoPreview=1 Public Humanities Launch | The Manifesto Issuenohttps://cassyni.com/events/i6wnaqCov2dzbDSajkHDF?videoPreview=12025-01-23T22:00:00+00:003451.32Public HumanitiesThis gathering will celebrate the launch of "Public Humanities," a new open-access journal from Cambridge University Press, and the publication of the first issue, called "The Manifesto Issue." All are welcome to join as authors from our inaugural issue share insights from their articles and set an agenda for public humanities in the decades ahead.https://cassyni-user-files-prod.s3.amazonaws.com/P4cypZ7MxSq9uwSSP6ooYa https://cassyni.com/events/DZcCfjL2YBTuEoRGbUkY37/abstract https://cassyni-user-files-prod.s3.amazonaws.com/WDQcXAapZrwKr5ZccRL4zr https://cassyni.com/events/A74yLwoMTybGD77hwpNaWH/seminar/qa https://cassyni.com/slides/outline/A74yLwoMTybGD77hwpNaWH https://cassyni.com/events/A74yLwoMTybGD77hwpNaWH/abstract https://cassyni-user-files-prod.s3.amazonaws.com/5EhyqxjkycfKctFSxkPaKg https://cassyni.com/events/A74yLwoMTybGD77hwpNaWH?videoPreview=1 Particle resuspension: challenges and perspectives for future modelsnohttps://cassyni.com/events/A74yLwoMTybGD77hwpNaWH?videoPreview=12024-11-07T13:00:00+00:003200.04Physics Reports Particle resuspension corresponds to the process by which discrete particles adhering on a surface are pulled off and carried away by a fluid flow. This is a typical example involving a web of phenomena pertaining to fluid mechanics, particle dynamics and interface chemistry whose cross-effects create an intricate topic. In this presentation, we bring insights into the rich complexity of the phenomena related to particle resuspension. This is illustrated on a few selected examples, which highlight both the challenges faced when measuring particle resuspension and the questions raised when building up models that reproduce some of the processes occurring at extremely different space and time scales. During this journey through multiscale approaches for complex physical phenomena, insights on ongoing ideas and developments are provided to stimulate interest into this everyday but challenging issue in physics.https://cassyni-user-files-prod.s3.amazonaws.com/5EhyqxjkycfKctFSxkPaKg https://cassyni.com/slides/outline/WrKyQHVHJZmnjgE1KKvQSq https://cassyni.com/events/WrKyQHVHJZmnjgE1KKvQSq/abstract https://cassyni-user-files-prod.s3.amazonaws.com/5dhoS9aTQibsrxrqPACrdC https://cassyni.com/events/WrKyQHVHJZmnjgE1KKvQSq?videoPreview=1 Soil CO2 flux maps as tools to reduce the risk on soil diffuse degassing areasnohttps://cassyni.com/events/WrKyQHVHJZmnjgE1KKvQSq?videoPreview=12024-10-30T09:00:00+00:003239.68Frontiers in Earth ScienceCarbon dioxide released permanently from soils in diffuse degassing areas may constitute a permanent hazard for the population. Several villages in the Azores archipelago (Portugal) are placed in areas with anomalous soil CO2 degassing and lethal indoor CO2 concentration (> 10 vol.%) has been already recorded in some buildings. The 2021-2022 dislodgements of population at Vulcano (Italy) and La Palma (Spain) volcanic islands due to high soil CO2 degassing highlight the importance of defining criteria to produce human CO2 exposure risk maps, which are useful to mitigate the risk and should constitute valuable tools for land-use planners. Risk is assessed in the current study by combining susceptibility, exposure, and vulnerability maps. The defined criteria were applied to two villages in Furnas Volcano (São Miguel Island, Azores), showing that 58% and 98% of the buildings, respectively, at Furnas and Ribeira Quente villages are at high risk of CO2 exposure.https://cassyni-user-files-prod.s3.amazonaws.com/5dhoS9aTQibsrxrqPACrdC https://cassyni.com/events/B6PoYwcHkFd92eDxJCPgAy/abstract https://cassyni-user-files-prod.s3.amazonaws.com/YV82FKsf4p7MJJqK2Y1nYv https://cassyni.com/slides/outline/XM1CZbeh9PFcZ9DX7S3Nd3 https://cassyni.com/events/XM1CZbeh9PFcZ9DX7S3Nd3/abstract https://cassyni-user-files-prod.s3.amazonaws.com/TvGyUgqY9rg3vjAd35wdvW https://cassyni.com/events/XM1CZbeh9PFcZ9DX7S3Nd3?videoPreview=1 The rise in pH of guard cells: An intriguing component of stomatal closurenohttps://cassyni.com/events/XM1CZbeh9PFcZ9DX7S3Nd3?videoPreview=12024-10-23T12:00:00+00:001678.68The New Phytologist FoundationStomatal movements are associated with pH changes in guard cells. Several authors have demonstrated that cytosolic alkalinization preceded the rise in ROS or Ca2+of guard cells. In contrast, a few reports suggest that the increase in cytosolic pH follows the elevated ROS or Ca2+, suggesting that cytosolic pH rise may not always be an early event. The components, such as ROS, Ca2+, and Ca2+-dependent protein kinases, converge to modulate ion channels, promote ion efflux from guard cells and promote stomatal closure. We propose a hypothetical model to integrate the event of pH rise with other signalling components and explain the argument that cytosolic alkalization can occur downstream or upstream of ROS or Ca2+-rise. Changes in guard cell pH can occur when ATPases are modulated. Stomatal closure and guard cell pH rise are compromised in mutants deficient in vacuolar H+-ATPase (V-ATPase), pointing out the role of V-ATPase. My talk attempts to consider arguments for and against the significance of cytosolic alkalinization in guard cells. Stomatal guard cells are promising model systems for further research into this intriguing topic of cytosolic pH change during stomatal closure.https://cassyni-user-files-prod.s3.amazonaws.com/TvGyUgqY9rg3vjAd35wdvW https://cassyni.com/slides/outline/97q1UqY5PnLUVAjuYcc1dF https://cassyni.com/events/97q1UqY5PnLUVAjuYcc1dF/abstract https://cassyni-user-files-prod.s3.amazonaws.com/EKB8kjMTEujfRY19vbedLz https://cassyni.com/events/97q1UqY5PnLUVAjuYcc1dF?videoPreview=1 Nonlinear dynamics of a synthetic spider webnohttps://cassyni.com/events/97q1UqY5PnLUVAjuYcc1dF?videoPreview=12021-02-16T13:00:00+00:00517.4NODYSSpiders dedicate a significant amount of energy and a variety of different types of silk to build their webs. Therefore, it has been speculated that spider webs are more than just simple traps. Spider web are highly complex mechanical structures that might act also as mechanical filters that significantly enhance and extend the sensory capabilities of spiders, enabling them to identify and localise preys and predators. This paper experimentally investigates the dynamic behaviour of a synthetic, 3D-printed spider web to identity general morphological features that can contribute to this filtering capability. First results show, even a simple, artificial web exhibits a wide range of complex dynamic behaviours such as sub- and super-harmonic interactions.https://cassyni-user-files-prod.s3.amazonaws.com/EKB8kjMTEujfRY19vbedLz https://cassyni.com/events/PwJkyyThxssYtG9gME1p7w/seminar/qa https://cassyni.com/slides/outline/PwJkyyThxssYtG9gME1p7w https://cassyni.com/events/PwJkyyThxssYtG9gME1p7w/abstract https://cassyni-user-files-prod.s3.amazonaws.com/BStezrSZqJmmQQDDoLS6Jz https://cassyni.com/events/PwJkyyThxssYtG9gME1p7w?videoPreview=1 JWPE 3-Minute Pitch "My Life in Water" event winning presentationsnohttps://cassyni.com/events/PwJkyyThxssYtG9gME1p7w?videoPreview=12025-01-20T09:00:00+00:004270.04ElsevierThe Winners of the JWPE 3-Minute Pitch: "My Life in Water" event will each present a 15 minute talk about their research topic. The JWPE 3-Minute Pitch "My Life in Water" event, was a global initiative dedicated to celebrating outstanding PhD research in water processing and engineering. This initiative aims to support emerging researchers by providing a platform within the Journal of Water Process Engineering for them to showcase their work. Participants faced the challenge of distilling their research into a compelling three-minute presentation, using language accessible to a non-specialist audience. Congratulations to our winners and presnsters for this webinar: 1st place: Ms. Hanwei Yu, University of Technology Sydney, Australia for her presentation on Extracting Lithium from Water for a Sustainable Future 2nd place: Ms. Mbokazi Ngayeka, Nelson Mandela University, South Africa for her presentation on Synthesis of composite track-etched membranes for metal recovery in mine wastewater 3rd place: Ms. Jin Du, Tsinghua University, China for her presentation on Simultaneous CO2 reduction and Wastewater Treatment via Bioelectrochemical Systemhttps://cassyni-user-files-prod.s3.amazonaws.com/BStezrSZqJmmQQDDoLS6Jz https://cassyni.com/events/RuuBAi3oii6JyyRuiBskYV/seminar/qa https://cassyni.com/slides/outline/RuuBAi3oii6JyyRuiBskYV https://cassyni.com/events/RuuBAi3oii6JyyRuiBskYV/abstract https://cassyni-user-files-prod.s3.amazonaws.com/5aRrBKktwvHkWti6foGft2 https://cassyni.com/events/RuuBAi3oii6JyyRuiBskYV?videoPreview=1 On-the-fly clustering for exascale molecular dynamics simulations.nohttps://cassyni.com/events/RuuBAi3oii6JyyRuiBskYV?videoPreview=12025-03-03T14:00:00+00:003352.92Computer Physics CommunicationsComputational resources have experienced exponential growth in the last decades enabling the simulation of complex physical problems at the cost of a massive increase in data storage. This is especially true for N-body simulations now reaching billions or trillions particles in certain cases. To overcome the drawbacks of data storage on disk for post-processing purposes, on-the- fly analysis has gained momentum but still represents a challenge in both its implementation and efficiency without impacting the simulation engine performances. This work provides a new in- situ procedure for features detection in massive N-body simulations, leveraging state-of-the-art techniques from various fields. Based on a discrete-to-continuum paradigm shift, particles and their respective physical quantities are projected onto a 3D regular grid before applying image analysis algorithms to group voxels based on specific user-defined criteria. A significant extension to the hybrid parallelism of connected component analysis within the image processing community is also introduced in the present study. Traditionally operating in shared memory parallelism, this extension now incorporates both distributed and shared memory approaches. The implementation is carried out within the exaStamp classical Molecular Dynamics code, a variant of the open- source exaNBody platform (see section 6). This adaptation allows for the on-the-fly analysis of multi-billion atoms samples with at most a 1.3% overhead. In addition, the entire framework is benchmarked up to 32768 cores. The applicability of the present approach is demonstrated on the case of a spall fracture in a tantalum sample as well as high velocity impact of a tin droplets on a rigid surfacehttps://cassyni-user-files-prod.s3.amazonaws.com/5aRrBKktwvHkWti6foGft2 https://cassyni.com/slides/outline/JzpiX8zTaJLXVASLLkJpPo https://cassyni.com/events/JzpiX8zTaJLXVASLLkJpPo/abstract https://cassyni-user-files-prod.s3.amazonaws.com/A5UtNZ7ja4JrZ1CmGGUHQa https://cassyni.com/events/JzpiX8zTaJLXVASLLkJpPo?videoPreview=1 Upzoning and Gentrification: Heterogeneous Impacts of Neighbourhood-level Upzoning in New York Citynohttps://cassyni.com/events/JzpiX8zTaJLXVASLLkJpPo?videoPreview=12025-02-24T22:00:00+00:002530.16The University of Auckland Business SchoolIn light of the calls to relax restrictive density regulations, this paper examines how increasing residential development capacity, i.e. upzoning, may change the demographic, socio-economic and housing characteristics of the affected neighbourhoods. We examine the neighbourhood-level upzonings of New York City to answer this question. We find that upzoning is positively associated with signs of gentrification – upzoned neighbourhoods became whiter, more educated and more affluent in the long run. Upzoning is also associated with increases in housing production, but housing prices also increased. Most importantly, we find that these effects varied significantly by the intensity of upzoning and the pre-upzoning local contexts. Neighbourhoods affected by intense upzonings experienced gentrification more intensely, along with greater housing production, rent growth and housing price appreciation. Black-majority and low-income neighbourhoods experienced gentrification to the greatest extent, while neighbourhoods with high demand for housing saw the greatest increases in housing supply. We discuss different mechanisms of gentrification likely at play for the different types of neighbourhoods. https://cassyni-user-files-prod.s3.amazonaws.com/A5UtNZ7ja4JrZ1CmGGUHQa https://cassyni.com/slides/outline/VNSQVVaUnuxx1fjUMrFi5K https://cassyni.com/events/VNSQVVaUnuxx1fjUMrFi5K/abstract https://cassyni-user-files-prod.s3.amazonaws.com/8BBmES8X7E8sDzZ7t4UVT4 https://cassyni.com/events/VNSQVVaUnuxx1fjUMrFi5K?videoPreview=1 Deciphering sepsis: transforming diagnosis and treatment through systems immunologynohttps://cassyni.com/events/VNSQVVaUnuxx1fjUMrFi5K?videoPreview=12025-03-25T15:00:00+00:005582.84Frontiers in ScienceExplore how systems immunology could revolutionize sepsis diagnosis and treatment—improving patient outcomes and saving millions of lives. This event builds on a [*Frontiers in Science* lead article](https://www.frontiersin.org/journals/science/articles/10.3389/fsci.2024.1469417/full) outlining new developments in omics and epigenetics, bioinformatics, and machine learning for precision medicine strategies in sepsis care. This includes methods for early detection, patient endotyping, and individualized, stage-specific therapies. You’ll hear from the article authors and other experts on how collaborative efforts can drive innovation and inform pathogen-agnostic strategies for future pandemic preparedness. [Register here](https://events.frontiersin.org/deciphering-sepsis/C)https://cassyni-user-files-prod.s3.amazonaws.com/8BBmES8X7E8sDzZ7t4UVT4 https://cassyni.com/events/5AfoDzsmHUq3qyydS4xQey/seminar/qa https://cassyni.com/slides/outline/5AfoDzsmHUq3qyydS4xQey https://cassyni.com/events/5AfoDzsmHUq3qyydS4xQey/abstract https://cassyni-user-files-prod.s3.amazonaws.com/UGpKkw6G6PPFmaz85mQMti https://cassyni.com/events/5AfoDzsmHUq3qyydS4xQey?videoPreview=1 Imagining the University Differently: The Tactics of Transformationnohttps://cassyni.com/events/5AfoDzsmHUq3qyydS4xQey?videoPreview=12025-05-15T16:00:00+00:002812.4Lived Places PublishingPanelists will discuss how the university fails to serve the majority of people that move through it and what can be done about these failures. Themes discussed will include oppression and knowledge production in the university, divisions of labor between faculty, staff, and students, what aspects of the university are worth keeping, and tactics for transforming the university, from within and without.https://cassyni-user-files-prod.s3.amazonaws.com/UGpKkw6G6PPFmaz85mQMti https://cassyni.com/slides/outline/4BNb8daiQZiuBE9dL6V5r5 https://cassyni.com/events/4BNb8daiQZiuBE9dL6V5r5/abstract https://cassyni-user-files-prod.s3.amazonaws.com/RF1YafET1YsAFkAZ7UGcwp https://cassyni.com/events/4BNb8daiQZiuBE9dL6V5r5?videoPreview=1 Reflection on Applied Computational Aerodynamics Effectiveness for Aircraft Designnohttps://cassyni.com/events/4BNb8daiQZiuBE9dL6V5r5?videoPreview=12024-12-07T17:00:00+00:002187.28JKW Symposium Teamnull Image credit: [Daniel McCullough (Unsplash)](https://unsplash.com/photos/person-drafting-on-blueprint--FPFq_trr2Y).https://cassyni-user-files-prod.s3.amazonaws.com/RF1YafET1YsAFkAZ7UGcwp https://cassyni.com/events/EYzH6zAjdBMKhjSmMCRyXb/abstract https://cassyni-user-files-prod.s3.amazonaws.com/EnWSbDBJX3GpkVhreTJV18 https://cassyni.com/events/QRyz9Hd7ohMNhj9C9L8nJ9/seminar/qa https://cassyni.com/slides/outline/QRyz9Hd7ohMNhj9C9L8nJ9 https://cassyni.com/events/QRyz9Hd7ohMNhj9C9L8nJ9/abstract https://cassyni-user-files-prod.s3.amazonaws.com/MSkZAzwJx6nYPnTiM3aPsk https://cassyni.com/events/QRyz9Hd7ohMNhj9C9L8nJ9?videoPreview=1 A Philosophy of Turbulence Modelingnohttps://cassyni.com/events/QRyz9Hd7ohMNhj9C9L8nJ9?videoPreview=12025-08-19T16:00:00+00:004241.2AIAA JournalBased on our experience and passion for the subject, we attempt a lucid description of the activity called Turbulence Modeling, its motivation, its rules, its unwritten principles, its sources of information, and sadly its many fallacies. Modeling is an essential enabler for CFD, and most of the time the model constitutes a gift to the community by the individuals and their institutions, whether government, industry, or university. Prestige is a motivation, but progress is its own reward. We contrast Intuitive and Constructed models. Rules begin with dimensional analysis, but include proper behavior at the edge of a turbulent region. Debatable guiding principles include the requirement for the Partial Differential Equations to be local, and the relationship with the exact Reynolds-Stress transport equations. Information comes from experiments and Direct Numerical Simulations, in both simple and complex flows. All the classical models are shown to suffer a "Structural Limitation" expressed by a General Law of the Wall which is physically incorrect. Fallacies include the idea that the Boussinesq approximation returns an isotropic stress tensor, the importance of realizability, the distinction between normal and off-diagonal Reynolds stresses, and of course the idea that one-equation models don't work.https://cassyni-user-files-prod.s3.amazonaws.com/MSkZAzwJx6nYPnTiM3aPsk https://cassyni.com/events/FYK7JyyfuTPCWxyAjjqjy7/seminar/qa https://cassyni.com/slides/outline/FYK7JyyfuTPCWxyAjjqjy7 https://cassyni.com/events/FYK7JyyfuTPCWxyAjjqjy7/abstract https://cassyni-user-files-prod.s3.amazonaws.com/VWaLhJXqDmyDpRvhLkFcii https://cassyni.com/events/FYK7JyyfuTPCWxyAjjqjy7?videoPreview=1 20th International Biometals Webinarsnohttps://cassyni.com/events/FYK7JyyfuTPCWxyAjjqjy7?videoPreview=12025-11-04T14:00:00+00:005544.04BioMetalsThe seminar addressed critical aspects of metal ion homeostasis in biological systems, focusing on mechanisms of metal uptake and transmembrane metal transport. The first part elucidated the role of CD44, a transmembrane glycoprotein, in mediating cellular uptake of essential metals such as copper and iron, which act as catalysts in cell state transitions relevant to cancer metastasis and immune responses. Using mass spectrometry, proteomic analyses, and functional assays, it was demonstrated that CD44-dependent endocytosis facilitates iron trafficking to the nucleus and copper to mitochondria, enabling epigenetic regulation via iron- and α-ketoglutarate-dependent demethylases. This pathway supports cellular plasticity, drug tolerance, and metastatic potential, distinct from canonical transferrin receptor-mediated iron uptake. Novel therapeutic strategies were proposed, including bifunctional lipid degraders targeting lysosomal iron to induce ferroptosis selectively in drug-tolerant cancer cells, and lipophilic copper clamps that inhibit mitochondrial copper-dependent inflammatory activation, showing efficacy in sepsis models. The second part focused on the molecular and atomic-level characterization of P1B-type ATPase metal pumps, specifically copper (P1B-1) and zinc (P1B-2) transporters. Employing X-ray absorption spectroscopy, mutagenesis, and reconstituted proteoliposome assays with fluorescent probes, the study revealed distinct coordination chemistries and transport mechanisms: copper pumps utilize sulfur-based ligand exchange pathways and operate as electrogenic uniporters without proton counter-transport, whereas zinc pumps exhibit coordination plasticity allowing promiscuous substrate binding and also function as electrogenic uniporters. Machine learning-generated artificial pumps with enhanced catalytic efficiency and metal-organic framework stabilization of proteoliposomes were introduced as innovative methodological advances. These findings advance understanding of metal transporter specificity, kinetics, and their integration into cellular metal homeostasis, offering insights for targeted therapeutic interventions in metal-related diseases.https://cassyni-user-files-prod.s3.amazonaws.com/VWaLhJXqDmyDpRvhLkFcii https://cassyni.com/slides/outline/UP9CQ8HRuzroLuuUFsnPGR https://cassyni.com/events/UP9CQ8HRuzroLuuUFsnPGR/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Kd3bMPW54m1PeWkUgH3Sd4 https://cassyni.com/events/UP9CQ8HRuzroLuuUFsnPGR?videoPreview=1 Uptake and accumulation of emerging contaminants in agro-ecosystemsnohttps://cassyni.com/events/UP9CQ8HRuzroLuuUFsnPGR?videoPreview=12024-08-13T12:00:00+00:001229.2The New Phytologist FoundationEmerging contaminants, such as pharmaceuticals, are inadvertently released into agricultural systems following the use of materials such as wastewater, biosolids and manure to meet crop nutrient and irrigation demands. Following targeted monitoring campaigns, we have identified a suite of human use pharmaceuticals and veterinary medicines in wastewater irrigated and biosolid/manure amended soils in the UK. Identified contaminants are diverse in nature (i.e. various therapeutic classes) and observed at a range of concentrations. However as monitoring campaigns typically focus on a small number of chemicals (~50) due to the availability of analytical methods, very little is known about the fate and accumulative potential of the hundreds of pharmaceuticals currently in use. A novel modelling approach was therefore developed which utilised high-resolution mass spectrometry datasets to identify pharmaceuticals in effluents and coupled this to a model framework to predict the accumulative potential of a pharmaceutical in wastewater irrigated crops based on chemical structure alone. Following this approach a prioritised list of pharmaceuticals was identified and a risk evaluation undertaken.https://cassyni-user-files-prod.s3.amazonaws.com/Kd3bMPW54m1PeWkUgH3Sd4 https://cassyni.com/slides/outline/7dupTR7PUmbYCvTByks3Nu https://cassyni.com/events/7dupTR7PUmbYCvTByks3Nu/abstract https://cassyni-user-files-prod.s3.amazonaws.com/9fp99E5BQid5ovCHpTvQaa https://cassyni.com/events/7dupTR7PUmbYCvTByks3Nu?videoPreview=1 Evaluating the Accuracy and Robustness of the Rotated-RoeM Scheme in Hypersonic Flow Computationsnohttps://cassyni.com/events/7dupTR7PUmbYCvTByks3Nu?videoPreview=12024-12-05T11:00:00+00:001919.68JKW Symposium TeamThis talk presents the development and extension of the Rotated-RoeM flux scheme for accurately resolving strong shock waves in hypersonic flows using a compact stencil approach. The Roe scheme suffers from shock instability issues when applied to hypersonic flow. To address this, the rotated hybrid concept is introduced, effectively mitigating shock instabilities while maintaining computational efficiency on unstructured grids. Additionally, a Mach-number-based weighting function is implemented to distinguish between boundary layer flow and shock instability regions. This scheme is further extended to solve hypersonic equilibrium flow, demonstrating its versatility. Numerical analyses confirm its effectiveness in capturing multi-dimensional shock waves, resolving thermal boundary layers, and accurately predicting heat transfer rates in hypersonic flows.https://cassyni-user-files-prod.s3.amazonaws.com/9fp99E5BQid5ovCHpTvQaa https://cassyni.com/events/F3dt9fpG4duNhVyewdimnu/seminar/qa https://cassyni.com/slides/outline/F3dt9fpG4duNhVyewdimnu https://cassyni.com/events/F3dt9fpG4duNhVyewdimnu/abstract https://cassyni-user-files-prod.s3.amazonaws.com/DjiN1D9eRBQD7hXxzkouPL https://cassyni.com/events/F3dt9fpG4duNhVyewdimnu?videoPreview=1 Rare earth monoxides with divalent rare earth ions (RE = Y, lanthanoid): from superconductor to room temperature ferromagnetnohttps://cassyni.com/events/F3dt9fpG4duNhVyewdimnu?videoPreview=12025-05-08T01:00:00+00:003412.16School of Chemical and Physical SciencesRare earth (RE) binary oxides are usually sesquioxides (RE2O3) with trivalent RE ions, and are highly insulating and nonmagnetic (or antiferromagnetic at low temperature). On the other hand, rare earth monoxides (REO) with divalent RE ions are very few because of their metastable nature, except for EuO and YbO. In early 1980s, light REO (RE = La to Sm) polycrystals were obtained by high pressure synthesis, while no subsequent studies have been reported. Recently, many REO (RE = Y, La to Lu) can be synthesized via thin film epitaxy. Owing to the divalent RE ions, most of REO possess an itinerant 4d or 5d electron, leading to high electrical conduction, superconductivity, room temperature ferromagnetism, etc. In this talk, we showcase electrical and magnetic properties of REO (RE = Y, La to Lu except for radioactive Pm, conventional Eu, and Tm). https://cassyni-user-files-prod.s3.amazonaws.com/DjiN1D9eRBQD7hXxzkouPL https://cassyni.com/events/9cWEe9hVEbpJJdjRLiiyoT/seminar/qa https://cassyni.com/slides/outline/9cWEe9hVEbpJJdjRLiiyoT https://cassyni.com/events/9cWEe9hVEbpJJdjRLiiyoT/abstract https://cassyni-user-files-prod.s3.amazonaws.com/XnMkmTLx4LVZBk3tQGRZL2 https://cassyni.com/events/9cWEe9hVEbpJJdjRLiiyoT?videoPreview=1 LALS Staff Flash Talksnohttps://cassyni.com/events/9cWEe9hVEbpJJdjRLiiyoT?videoPreview=12025-03-14T00:10:00+00:003030.0Linguistics and Applied Language StudiesAt the Friday LALS seminar this week the LALS Staff will share brief talks about their work. Come along and find out what everyone is up to 😊 https://cassyni-user-files-prod.s3.amazonaws.com/XnMkmTLx4LVZBk3tQGRZL2 https://cassyni.com/events/H2FvT2vFDq3rwgxHbAX9r5/abstract https://cassyni-user-files-prod.s3.amazonaws.com/8DY9yqWDzAtVxrKbzncvtv https://cassyni.com/events/KVVwgT9sR7pMJdRr8rRna1/abstract https://cassyni-user-files-prod.s3.amazonaws.com/3XNv3LrjpKdXQFFpF5WCSa https://cassyni.com/events/TPTGhwmyQ2nPGjDZMun5q7/seminar/qa https://cassyni.com/slides/outline/TPTGhwmyQ2nPGjDZMun5q7 https://cassyni.com/events/TPTGhwmyQ2nPGjDZMun5q7/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Gy9BkMeUudQtDKCJUfmqqY https://cassyni.com/events/TPTGhwmyQ2nPGjDZMun5q7?videoPreview=1 Using implementation science to improve screening for MASLD in the primary care settingnohttps://cassyni.com/events/TPTGhwmyQ2nPGjDZMun5q7?videoPreview=12025-10-16T20:00:00+00:003350.68Family MedicineBackground: Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common chronic liver condition worldwide, yet remains underdiagnosed in primary care. Early detection can prevent progression to cirrhosis and reduce downstream healthcare costs. However, uptake of MASLD screening remains low, even when evidence-based guidelines and tools are available. Objective: This talk will illustrate how implementation science can be used to design, evaluate, and adapt strategies to improve MASLD screening in primary care. Special emphasis will be placed on the use of Causal Pathway Diagrams (CPDs) to understand why strategies may fail and to guide iterative refinement. Approach: We applied an implementation science framework to identify determinants of MASLD screening, select strategies to address barriers, and map hypothesized mechanisms using CPDs. Despite initial deployment of strategies such as clinical decision support, provider education, and workflow prompts, screening rates remained suboptimal. We then used CPDs to trace each strategy’s theoretical pathway, examining intermediate outcomes (e.g., clinician awareness, workflow fit, patient follow-through) to locate points of failure and hypothesize new adaptations. Results & Lessons Learned: CPD-informed analysis revealed that low screening rates were not due to clinician knowledge gaps (as initially assumed) but to limited visit time, lack of streamlined follow-up protocols, and competing clinical priorities. This insight led to a second-generation implementation package emphasizing team-based task-shifting, EHR order sets with automated follow-up scheduling, and population health outreach. Implications: CPDs offer a systematic way to move beyond “did it work?” toward “why did it or didn’t it work?”—enabling a learning health system approach to improving MASLD screening. This talk will provide practical guidance for researchers and health systems on integrating CPDs into implementation efforts and adapting strategies in real time.https://cassyni-user-files-prod.s3.amazonaws.com/Gy9BkMeUudQtDKCJUfmqqY https://cassyni.com/events/Xqi3qYKzPZfDCJff7CzWi9/abstract https://cassyni-user-files-prod.s3.amazonaws.com/VTR8yEKnrrh2bsLzJcfgH4 https://cassyni.com/events/Ca19KSNEEJAkxnvrMFxMHP/abstract https://cassyni-user-files-prod.s3.amazonaws.com/2Bk3DbgBmaarNhZcazRmtr https://cassyni.com/events/Ly43Dgt36SWUGbyihgDr8u/seminar/qa https://cassyni.com/slides/outline/Ly43Dgt36SWUGbyihgDr8u https://cassyni.com/events/Ly43Dgt36SWUGbyihgDr8u/abstract https://cassyni-user-files-prod.s3.amazonaws.com/3JgGMTFCqN4AP8ZvLuJdCA https://cassyni.com/events/Ly43Dgt36SWUGbyihgDr8u?videoPreview=1 Applications of Nektar++ IInohttps://cassyni.com/events/Ly43Dgt36SWUGbyihgDr8u?videoPreview=12025-06-26T10:00:00+00:004792.88Nektar++ Development TeamThis presentation outlines recent progress in applying the implicit sliding mesh solver within the Nektar++ framework to simulate unsteady stator–rotor interactions in turbomachinery. A translating mesh around a cylinder is used to generate the inflow wake and simulate wake–blade interactions on a 3D T106A low-pressure turbine blade. This setup demonstrates the capability of the solver for high-fidelity 3D simulations involving translating meshes and complex geometries. In parallel, we are validating the performance of the solver on 3D rotating meshes using Taylor–Couette flow benchmarks, considering both full-annulus and sector-domain configurations. These verification cases assess the accuracy, stability, and convergence behaviour of the solver under rotational motion. Together, these efforts lay the groundwork for future simulations of more realistic turbomachinery configurations. UKAEA is using Nektar++ as the fluid component of its NESO framework: a collection of software intended to model the edge plasma in a tokamak. This problem is being approached using a number of different methods ranging in fidelity and computational expense. Nektar++ has been coupled to the NESO-Particles library - this has been further extended with coupling to our atomic reactions library. The resulting code, NESO-Tokamak, will solve the Braginskii fluid equations for multiple ionic species, with source terms provided by the reactions. Axisymmetric 2D and 3D steady-state and transient transport solutions have been produced, and turbulent solutions are being worked on. The core component is a Nektar++ unsteady solver, which has been extended with several features. Another component of NESO is the meshing software NESO-fame, which produces non-conformal meshes aligned with the magnetic field in order to account for the high anisotropy of the equations. We propose a novel and simple way to generate inflow turbulent boundary layers (TBLs) that needs only a random forcing feature available from the solver and an extra (channel-like) part to be added to the domain of interest. As it does not rely on any specific physical modeling, it is more in line with implicit LES approaches, although it can also be used in a classic LES setting. The idea is basically to add a spatially developing turbulent channel flow (sustained by random forcing) to the domain so that its outlet is attached to the inlet of the domain of interest. The final trick is to set an outflow boundary condition at the upper half of the channel flow's outlet, so that only its lower part is released into the domain of interest as an inflow TBL. We note this is a type of precursor inlet TBL method, but one in which the precursor (channel) domain is carried alongside the domain of interest in a single unified simulation throughout the whole time of the computation. Although not necessarily computationally cheaper or more accurate than existing inflow TBL methods, the advocated approach has several benefits: it is extremely simple, requiring no specific TBL modeling and only minor (if any) adaptation to the solver of choice; it allows one to specify both the Reynolds number and TBL height at inflow; it does not suffer from problems that some inflow TBL methods have, such as the need for large stored databases and the artificial repetition of turbulent structures after a certain period. The methodology is demonstrated for incompressible flows in a spectral/hp continuous Galerkin (CG) implicit LES setting, but its extension to compressible flows is also discussed.https://cassyni-user-files-prod.s3.amazonaws.com/3JgGMTFCqN4AP8ZvLuJdCA https://cassyni.com/slides/outline/4g3pHwk8FPCizh998Cc42H https://cassyni.com/events/4g3pHwk8FPCizh998Cc42H/abstract https://cassyni-user-files-prod.s3.amazonaws.com/RoSiqUpmA7dhXnunU2mLDk https://cassyni.com/events/4g3pHwk8FPCizh998Cc42H?videoPreview=1 Scholarly Infrastructure at a Crossroads: Do we have a solid foundation on which to build or do we need to start from scratch?nohttps://cassyni.com/events/4g3pHwk8FPCizh998Cc42H?videoPreview=12025-01-14T15:00:00+00:004754.24Academic Publishing in EuropeNo abstracthttps://cassyni-user-files-prod.s3.amazonaws.com/RoSiqUpmA7dhXnunU2mLDk https://cassyni.com/events/MTjGP13SwFzJ64yEVnLpK7/abstract https://cassyni-user-files-prod.s3.amazonaws.com/42jJ5RAxeShoocx9xFydvE https://cassyni.com/events/Hz8NiHw6ZLv3U77WFg2kCV/seminar/qa https://cassyni.com/slides/outline/Hz8NiHw6ZLv3U77WFg2kCV https://cassyni.com/events/Hz8NiHw6ZLv3U77WFg2kCV/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Rxax9z5K6enus7UJ3HjnWi https://cassyni.com/events/Hz8NiHw6ZLv3U77WFg2kCV?videoPreview=1 Structures as Sensors: Scalable Monitoring of Infrastructure through Non-dedicated Sensorsnohttps://cassyni.com/events/Hz8NiHw6ZLv3U77WFg2kCV?videoPreview=12025-10-29T16:00:00+00:003547.28Data-Centric Engineering JournalWith increasing urbanization, civil infrastructure plays a key role in connecting, protecting, and supporting this growing population in cities. However, the large stock of aging infrastructure poses significant challenges to the economy and public safety. Smart structures are designed to sense, understand, and respond to the structural state and the human needs, but traditional monitoring approaches using dedicated sensors often result in dense sensing systems that are difficult to install and maintain in large-scale structures. This talk introduces non-dedicated sensing approaches that utilize vehicles and pre-existing telecommunication cables as sensors to indirectly infer infrastructure health, such as bridges and railways. Challenges lie, however, in creating robust inference models for analyzing noisy vibration response data. To this end, we created physics-guided data analytics approaches that combine statistical signal processing and machine learning with physical principles. We evaluate our system with field experiments through collaborations with the City of San Jose, CA, and the Korea Expressway Corporation. https://cassyni-user-files-prod.s3.amazonaws.com/Rxax9z5K6enus7UJ3HjnWi https://cassyni.com/events/LTNPwiAikdgXq3b4oMwNvR/seminar/qa https://cassyni.com/slides/outline/LTNPwiAikdgXq3b4oMwNvR https://cassyni.com/events/LTNPwiAikdgXq3b4oMwNvR/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Wujgf25fJvj1m3LGfczXi6 https://cassyni.com/events/LTNPwiAikdgXq3b4oMwNvR?videoPreview=1 Statistical Finite Element Methodsnohttps://cassyni.com/events/LTNPwiAikdgXq3b4oMwNvR?videoPreview=12025-10-09T12:00:00+00:003249.04MOX Laboratory - Department of MathematicsThe finite element method (FEM) is one of the great triumphs of applied mathematics, numerical analysis and software development. Recent developments in sensor and signalling technologies enable the phenomenological study of complex natural and physical systems. The connection between sensor data and FEM has been restricted to solving inverse problems placing unwarranted faith in the fidelity of the mathematical description of the system under study. If one concedes mis-specification between generative reality and the FEM then a framework to systematically characterise this uncertainty is required. This talk will present a statistical construction of the FEM which systematically blends mathematical description with data observations by endowing the Hilbert space of FEM solutions with the additional structure of a Probability Measure. This initiative is part of the “Ph.D. Lectures” activity of the project "Departments of Excellence 2023-2027" of the Department of Mathematics of Politecnico di Milano. This activity consists of seminars open to Ph.D. students, followed by meetings with the speaker to discuss and go into detail on the topics presented during the talk.https://cassyni-user-files-prod.s3.amazonaws.com/Wujgf25fJvj1m3LGfczXi6 https://cassyni.com/events/Ts6TdxsbLVzNKd7XmEo7LR/seminar/qa https://cassyni.com/slides/outline/Ts6TdxsbLVzNKd7XmEo7LR https://cassyni.com/events/Ts6TdxsbLVzNKd7XmEo7LR/abstract https://cassyni-user-files-prod.s3.amazonaws.com/AJvzC3ZMbjdhiLiG2sJkXY https://cassyni.com/events/Ts6TdxsbLVzNKd7XmEo7LR?videoPreview=1 Bandgap formation mechanisms in solid-air phononic crystals with 4-fold rotational symmetrynohttps://cassyni.com/events/Ts6TdxsbLVzNKd7XmEo7LR?videoPreview=12025-12-09T14:00:00+00:003728.4MetaMATThis study explores the mechanisms behind bandgap (BG) formation in two-dimensional solid-air phononic crystals (PnCs) with 4-fold rotational symmetry, focusing on the symmorphic p4 and p4mm groups, as well as the nonsymmorphic p4gm plane symmetry group. We propose design families based on these symmetry groups that are easy to reproduce, enabling systematic exploration of their properties. Through a comprehensive parametric analysis, we investigate the coupling between Bragg scattering and local resonance mechanisms, demonstrating the potential to achieve exceptionally wide, complete omnidirectional BGs in solid-air PnCs. Numerical simulations and experimental results confirm the presence of strongly coupled BGs with enhanced attenuation for both P- and S-waves, particularly in designs with large resonators and thin connectors. Notably, we achieve a rare 118% complete omnidirectional BG with attenuation levels reaching up to 80 dB after just three rows of unit cells. Our findings reveal that the arrangement of resonators and connectors — analogous to masses and springs — plays a pivotal role in the formation of coupled resonant-Bragg BGs. Thus, the study challenges traditional assumptions about the importance of symmetry in PnC design, showing that simpler symmorphic configurations can rival the BG performance of their nonsymmorphic counterparts. These insights advance our understanding of BG formation in solid-air PnCs and provide practical guidelines for designing more effective vibration dampers or waveguides.https://cassyni-user-files-prod.s3.amazonaws.com/AJvzC3ZMbjdhiLiG2sJkXY https://cassyni.com/events/YKwKAnFDncKQfpvuNPV5ZF/abstract https://cassyni-user-files-prod.s3.amazonaws.com/SXuviVjuDHHXH1AxCxprfx https://cassyni.com/events/88AhuHYWHBBWW9B4ScBn8u/abstract https://cassyni-user-files-prod.s3.amazonaws.com/JBUZJ1pTdNaHxVD91Cm8a https://cassyni.com/events/BZhX7QXGrPiMeHR3PmeLbP/seminar/qa https://cassyni.com/slides/outline/BZhX7QXGrPiMeHR3PmeLbP https://cassyni.com/events/BZhX7QXGrPiMeHR3PmeLbP/abstract https://cassyni-user-files-prod.s3.amazonaws.com/52ToPy2k8Ma8FoGyrXwQzA https://cassyni.com/events/BZhX7QXGrPiMeHR3PmeLbP?videoPreview=1 Hydrodynamic solar interfacial evaporation for seawater desalination-Gone with the windnohttps://cassyni.com/events/BZhX7QXGrPiMeHR3PmeLbP?videoPreview=12025-11-12T10:00:00+00:003468.08ElsevierEvaporation has been one of the most classic desalination processes on the Earth. When we try to use the power of water flow itself, the evaporation process can perform even better. Here, we report a hydrodynamic solar-driven interfacial evaporation process which water evaporation rate can achieve 6.58 kg·m-2·h-1 (over 100 times higher than natural evaporation). A waterwheel-structure solar interfacial evaporator was designed and assembled by printed filter papers. The evaporator can both rapidly distribute solution on the evaporation interface and be hydraulically driven to rotate continuously to improve the evaporation rate by water flow. The hydrodynamic solar-driven interfacial evaporation process successfully overcomes the problem of slow diffusion of water vapor, but also realizes the day-and-night operation of process and the self-cleaning of salt fouling. Apart from the application in solar desalination, the developed evaporator has great potentials in vapor production and salt recovery for industrial use.https://cassyni-user-files-prod.s3.amazonaws.com/52ToPy2k8Ma8FoGyrXwQzA https://cassyni.com/events/2h34PmRjT96S7GvpqhBz9T/seminar/qa https://cassyni.com/slides/outline/2h34PmRjT96S7GvpqhBz9T https://cassyni.com/events/2h34PmRjT96S7GvpqhBz9T/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Jj8TMNF8VzQp81zyA3AGg6 https://cassyni.com/events/2h34PmRjT96S7GvpqhBz9T?videoPreview=1 Advancing Affective Computing in Brain-Computer Interfaces Through Combined fNIRS and EEG Systemnohttps://cassyni.com/events/2h34PmRjT96S7GvpqhBz9T?videoPreview=12025-10-28T03:00:00+00:003713.8The Auckland Bioengineering InstituteThis research investigates the integration of Electroencephalography (EEG) and functional Near Infrared Spectroscopy (fNIRS) for emotion recognition in brain-computer interfaces. Three experimental protocols were designed to collect synchronized fNIRS and EEG data using video, sound, and music stimuli from participants. These experiments resulted in the fNIRS-EEG Affective Dataset (FEAD), a publicly available dataset that contributes to affective computing research. The research systematically evaluated multiple AI frameworks to develop reliable multimodal emotion recognition systems. Comparative analysis demonstrated that the multimodal approach consistently outperformed single-modality methods across both feature-based and end-to-end deep learning paradigms. Benchmark accuracies were established for both methodological approaches, providing reference standards for future research in this domain.​ To address cross-subject variability, a significant challenge in emotion recognition systems, domain adaptation techniques were implemented and validated. These methods enhanced the generalizability of the multimodal fNIRS-EEG system across different individuals. The thesis identifies key limitations of current approaches and proposes directions for future development in multimodal affective brain-computer interfaces.​ This work contributes to affective computing by establishing comprehensive benchmarks, demonstrating the advantages of multimodal neurophysiological signal integration, and providing validated methodologies for improving system robustness across diverse user populations.https://cassyni-user-files-prod.s3.amazonaws.com/Jj8TMNF8VzQp81zyA3AGg6 https://cassyni.com/slides/outline/A6m8628c31QGbrTHoa3iZT https://cassyni.com/events/A6m8628c31QGbrTHoa3iZT/abstract https://cassyni-user-files-prod.s3.amazonaws.com/LA3qV4dfaeegVVsowv1rd4 https://cassyni.com/events/A6m8628c31QGbrTHoa3iZT?videoPreview=1 Demonstrating the value of evidence syntheses to inform funding organisations’ decision-making practicesnohttps://cassyni.com/events/A6m8628c31QGbrTHoa3iZT?videoPreview=12025-06-18T13:00:00+00:003589.24The session aims to showcase the value of evidence syntheses in improving the practices of research funding organisations. Funders are facing growing demands to demonstrate impact, accountability and transparency in their practices. Evidence syntheses are comprehensive reviews that gather and analyse data from multiple studies on a specific topic, deepening our understanding and uncovering new insights. Driven by robust and rigorous evidence, evidence syntheses are essential mechanisms for implementing positive changes to research practices by providing funders, researchers, and institutions with the evidence needed to make well-informed decisions on policy and practice, noting that some may not have been extensively explored before. This session will draw on six evidence syntheses, covering diverse areas of interest to funders (e.g., realist review, scoping reviews). Using a case study approach, we will invite discussion on the value of using different types of evidence synthesis for different purposes and how the findings have relevance to stakeholders to inform decision-making. We hope that attendees will leave the session with a better understanding of the value of evidence syntheses to inform and enhance research practices. Six evidence syntheses that will be presented: * [Peer review and decision-making in research funding](https://researchintegrityjournal.biomedcentral.com/articles/10.1186/s41073-022-00120-2) * [Post-award effort of managing and reporting on funded research](https://f1000research.com/articles/12-863) * [Potential benefits and challenges of AI for research funding organisations](https://f1000research.com/articles/14-126) * [Use and acceptability of preprints in health and social care research](https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0291627) * [Methods and approaches for evidencing research impact](https://ror-hub.org/study/3296/) * [What constitutes a good research culture?](https://f1000research.com/articles/13-324) https://cassyni-user-files-prod.s3.amazonaws.com/LA3qV4dfaeegVVsowv1rd4 https://cassyni.com/events/PuwFP8DHECUwgSMFeh9WN9/seminar/qa https://cassyni.com/slides/outline/PuwFP8DHECUwgSMFeh9WN9 https://cassyni.com/events/PuwFP8DHECUwgSMFeh9WN9/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Bn5yhn74E67SbvjyGZ15S6 https://cassyni.com/events/PuwFP8DHECUwgSMFeh9WN9?videoPreview=1 Silent Flames: How Adipose Inflammation Fuels Cardiometabolic Disordersnohttps://cassyni.com/events/PuwFP8DHECUwgSMFeh9WN9?videoPreview=12026-03-26T11:00:00+00:003548.08The Pharmacological Research family of journalsFasting regimens have been widely used as a potential intervention for treating obesity and cardiometabolic dysfunction related to positive energy stress. Some evidence have shown that desired outcomes of fasting are present, regardless of caloric status or dietary modifications. Since adipose tissue inflammation has been identified as an integral part of fueling diet-induced cardiometabolic disorders, in this work we will explore the possible cardiometabolic changes in response to therapeutic fasting(TF), and its effect on adipose tissue in mild-hyper caloric(MHC)-induced cardiometabolic dysfunction. Male and ovulating female Sprague-Dawley rats were freely fed for the first 12-weeks on MHC, and were subjected to daily fasting from 7.00pm -7.00am for the following 12-weeks with free access to water, and to MHC-diet otherwise. They were compared to 24-weeks MHC and normal chow(NC) fed rats. Isocaloric TF was found to correct prediabetes and autonomic imbalance in male rats. It also interrupted the hypoxia machinery and alleviated the dysfunction of perivascular adipose tissue(PVAT); by reducing uncoupling protein 1(UCP1) expression and adipocytes size. While intact females did not present any insults after 24-weeks MHC exposure. To consider the role of female sex hormones additional groups of females were bilaterally ovariectomized(OVX) on week 12, then the same feeding groups were applied. OVX females had similar response to TF as the one observed in males. This preliminary data suggests the sex differential effect of TF and its possible crosstalk with adipose inflammation and cardiometabolic dysfunction. It also identifies possible mechanistic understanding of how TF exerts its protective effect. https://cassyni-user-files-prod.s3.amazonaws.com/Bn5yhn74E67SbvjyGZ15S6 https://cassyni.com/slides/outline/JUobsc6WQAPsHa723n9iNh https://cassyni.com/events/JUobsc6WQAPsHa723n9iNh/abstract https://cassyni-user-files-prod.s3.amazonaws.com/41drRo4HnXBYpEAD8rBoCi https://cassyni.com/events/JUobsc6WQAPsHa723n9iNh?videoPreview=1 Sweet shaping of root system architecture under water deficitnohttps://cassyni.com/events/JUobsc6WQAPsHa723n9iNh?videoPreview=12025-08-07T08:45:00+00:00868.56NoneRoot growth direction under water-deficit conditions is critical for plant survival. We used increased agar concentration in the growth medium to simulate stress conditions, limiting water availability. Our study highlights the role of glucose (Glc) in orchestrating the root growth deviation under stress conditions. We demonstrate that Glc-TOR signaling plays a central role in modulating root growth direction under stress conditions. Furthermore, our findings reveal that cytokinin signaling is instrumental in promoting root straightening during dehydration stress. The interplay between Glc-TOR and cytokinin signaling pathways fine-tunes root orientation by modulating auxin transport and signaling. Experiments with the horizontal growth conditions with Arabidopsis further support the role of Glc-TOR signaling in the regulation of root system architecture in stress conditions. Collectively, our findings reveal that Glc-induced changes in root architecture are mediated by downstream cytokinin and auxin pathways, contributing to enhanced root plasticity and improved adaptation to water-limited conditions.https://cassyni-user-files-prod.s3.amazonaws.com/41drRo4HnXBYpEAD8rBoCi https://cassyni.com/events/59JHd9dLYoSSeABCjY66uB/seminar/qa https://cassyni.com/slides/outline/59JHd9dLYoSSeABCjY66uB https://cassyni.com/events/59JHd9dLYoSSeABCjY66uB/abstract https://cassyni-user-files-prod.s3.amazonaws.com/5Px1BUmPTSzCWYFKEgpotr https://cassyni.com/events/59JHd9dLYoSSeABCjY66uB?videoPreview=1 (Electro)Hydrometallurgy - electrifying hydrometallurgical processes to obtain critical minerals towards sustainable miningnohttps://cassyni.com/events/59JHd9dLYoSSeABCjY66uB?videoPreview=12025-11-26T14:00:00+00:003571.8ElsevierThe transition to clean energy technologies demands a secure and sustainable supply of critical minerals. Conventional mining and refining processes are resource-intensive and environmentally costly. This presentation introduces the concept of (electro)hydrometallurgy, which integrates electrochemical principles into hydrometallurgical operations to enable selective, low-carbon recovery of valuable metals from low-grade ores and secondary sources such as mining waste and spent batteries. By coupling electrochemical driving forces with aqueous chemistry, (electro)hydrometallurgical systems can replace chemical reagents with electrons—reducing chemical consumption, minimizing waste generation, and improving process control. In this presentation, we will discuss recent developments, including electrodialysis-based separations for Li extraction from brine and battery recycling and ammonia recovery. Electrifying hydrometallurgy can drive the next generation of sustainable mining practices, advancing circular resource recovery while contributing to decarbonization and resilience in the global mineral supply chain.https://cassyni-user-files-prod.s3.amazonaws.com/5Px1BUmPTSzCWYFKEgpotr https://cassyni.com/events/F2GNYpZqKxWmVgBEF6rU37/seminar/qa https://cassyni.com/slides/outline/F2GNYpZqKxWmVgBEF6rU37 https://cassyni.com/events/F2GNYpZqKxWmVgBEF6rU37/abstract https://cassyni-user-files-prod.s3.amazonaws.com/9N52612FsRa1F2A4B3NonE https://cassyni.com/events/F2GNYpZqKxWmVgBEF6rU37?videoPreview=1 Extending the Method of Multiple Scales—higher-order solutions and strongly nonlinear systemsnohttps://cassyni.com/events/F2GNYpZqKxWmVgBEF6rU37?videoPreview=12025-12-11T15:00:00+00:002884.56Nonlinear Dynamics, an International Journal of Nonlinear Dynamics and Chaos in Engineering SystemsPerturbation methods, and the Method of Multiple Scales (MMS) in particular, provide a cornerstone for the analysis of nonlinear engineering systems. The presence of nonlinearities, often characterized as weak, can lead to unexpected dynamical behavior especially when the system is forced near a resonant frequency of the underlying linear system. This presentation discusses two novel extensions of this longstanding approach. The first applies MMS to a system of coupled oscillators in which the multiple scales approach is combined with harmonic balance solutions to approximate the dynamics of the population. In the second, higher-order approximations are developed that are both consistent and complete, in contrast to more common approaches that sacrifice one or the other. The resulting solutions are observed to be accurate across a wide range of parameters and forcing conditions. **Key Learning Objectives:** * Higher-order solutions may be required to accurately describe the coupling between modes or other global dynamics * Higher-order methods introduce additional variables, and closure of the resulting perturbation equations requires specific assumptions on the form of the solution **Who Should Attend** * Mechanical and aerospace engineers * Researchers/scientists in mechanical sciences and nonlinear dynamics https://cassyni-user-files-prod.s3.amazonaws.com/9N52612FsRa1F2A4B3NonE https://cassyni.com/slides/outline/G2ZzkrQnhryApBh3CbAUj7 https://cassyni.com/events/G2ZzkrQnhryApBh3CbAUj7/abstract https://cassyni-user-files-prod.s3.amazonaws.com/EQ8tyFGHk1q7ovYaxUQ5H8 https://cassyni.com/events/G2ZzkrQnhryApBh3CbAUj7?videoPreview=1 The Future of Public Cloud in NZnohttps://cassyni.com/events/G2ZzkrQnhryApBh3CbAUj7?videoPreview=12023-04-11T23:00:00+00:003385.64Business SchoolPublic cloud adoption represents a significant driver for economic growth and digital transformation in New Zealand. A recent IDC report, commissioned by Microsoft, indicates that public cloud contributed 6% to the nation's GDP in 2022 and is projected to create over 130,000 new jobs within the next five years. New Zealand demonstrates mature cloud adoption in the Asia Pacific region, moving beyond basic Software-as-a-Service solutions to more advanced use cases, with sectors such as banking, financial services, insurance, and government leading this trend. Annual spending on public cloud reached \$2.6 billion in 2022, with projections to nearly double to \$5.1 billion by 2026. This direct investment generates substantial knock-on economic benefits, resulting in \$23.9 billion in ecosystem revenue in 2022 and an anticipated cumulative growth of \$21 billion over the subsequent five years. Key advantages of local cloud infrastructure include enhanced digital sovereignty, reduced latency, and increased resilience. The development of a local hyperscale data center region, comprising three interconnected, energy-efficient sites, is poised to be 100% renewable from inception, further supporting sustainability goals. Organizational benefits of cloud adoption encompass financial flexibility, economic resilience, and transformational capabilities such as improved security, productivity, and the enablement of new business models. Leveraging these benefits necessitates cultural shifts, data-driven decision-making, agile operating models, and a focus on integrating advanced technologies like AI. Challenges remain, particularly addressing the significant technology skills shortage required to support this accelerated digital landscape, necessitating ongoing investment in capability building and talent pipelines.https://cassyni-user-files-prod.s3.amazonaws.com/EQ8tyFGHk1q7ovYaxUQ5H8 https://cassyni.com/events/KU8S5buSgSRk6odRSKZUpD/seminar/qa https://cassyni.com/slides/outline/KU8S5buSgSRk6odRSKZUpD https://cassyni.com/events/KU8S5buSgSRk6odRSKZUpD/abstract https://cassyni-user-files-prod.s3.amazonaws.com/MESXkzV44n8cLamtjMifY https://cassyni.com/events/KU8S5buSgSRk6odRSKZUpD?videoPreview=1 Temporal and Spatial Composition of the Tumor Microenvironment Predicts Response to Immune Checkpoint Inhibitionnohttps://cassyni.com/events/KU8S5buSgSRk6odRSKZUpD?videoPreview=12026-04-16T18:00:00+00:003666.84Center for Cancer TrainingImmune checkpoint inhibition (ICI) benefits only a subset of patients with metastatic triple-negative breast cancer, and determinants of response remain unclear. We assembled a longitudinal cohort of 103 female patients from the phase II TONIC trial with samples spanning primary tumors, pre-treatment metastases, and on-treatment metastases during nivolumab therapy. We profiled 37 proteins in 270 tumors using highly multiplexed imaging and developed SpaceCat, an open-source pipeline that extracts more than 800 imaging features per sample, including cell density, diversity, spatial interactions, and functional marker expression. Metastatic, but not primary, tumors contained features predictive of outcome. Spatial metrics such as immune diversity and T-cell infiltration at tumor borders were most informative, while ratios of T cells to cancer cells and PD-L1 on myeloid cells were also associated with response. Multivariate models stratified patients with highest performance on-treatment (AUC = 0.90). Bulk RNA-seq confirmed the predictive value of on-treatment samples. These findings highlight the value of longitudinal profiling to resolve evolving TME dynamics driving ICI response.https://cassyni-user-files-prod.s3.amazonaws.com/MESXkzV44n8cLamtjMifY https://cassyni.com/slides/outline/XpLYEh5ZetGbzUsEQg8CxM https://cassyni.com/events/XpLYEh5ZetGbzUsEQg8CxM/abstract https://cassyni-user-files-prod.s3.amazonaws.com/WJrScv2r28TeUJsXRNmdbk https://cassyni.com/events/XpLYEh5ZetGbzUsEQg8CxM?videoPreview=1 Control of water waves by time-varying metamaterialsnohttps://cassyni.com/events/XpLYEh5ZetGbzUsEQg8CxM?videoPreview=12026-02-03T14:00:00+00:002711.12MetaMATThe control of water waves using time-varying metamaterials is investigated. These metamaterials consist of vertical, infinitesimally thin, rigid plates placed on the fluid bottom, with time-dependent height. First, we focus on a single vertically oscillating plate placed perpendicularly to the direction of propagation in a water channel. The scattering problem of a monochromatic wave incident on the oscillating plate is solved in the shallow water limit, yielding the generation of harmonics around the fundamental frequency. Then, the stability of the free water surface with respect to the plate oscillation is characterized inside a closed cavity, revealing parametric amplification windows. Finally, a plate array with the property to descend abruptly at the fluid bottom is used in order to deflect a wavepacket in shallow water. The plate array creates an effective anisotropic medium, which modifies the direction of the group velocity vector compared to a plate-free domain. By removing the plate array, the medium is switched to isotropic and the wavepacket is redirected. This mechanism, combining anisotropy and temporal interface to deflect wavepackets and known as temporal aiming, is demonstrated experimentally using space–time resolved measurements.https://cassyni-user-files-prod.s3.amazonaws.com/WJrScv2r28TeUJsXRNmdbk https://cassyni.com/events/SPCtjAxnprBXbcczom8Qxu/seminar/qa https://cassyni.com/slides/outline/SPCtjAxnprBXbcczom8Qxu https://cassyni.com/events/SPCtjAxnprBXbcczom8Qxu/abstract https://cassyni-user-files-prod.s3.amazonaws.com/HTnno3J1M5xytJVQzCxNP8 https://cassyni.com/events/SPCtjAxnprBXbcczom8Qxu?videoPreview=1 Inspiring Family Medicine Research: A conversation about journeys, lessons learned along the way, and future directionsnohttps://cassyni.com/events/SPCtjAxnprBXbcczom8Qxu?videoPreview=12026-02-05T21:00:00+00:003591.04Family MedicineAt the conclusion of this presentation, participants will be able to: - Describe key inflection points, challenges, and enabling factors across the career trajectory of a family medicine physician–scientist, and how these experiences inform sustainable, impactful research careers in academic family medicine. - Identify practical lessons learned related to mentorship, collaboration, funding strategy, and institutional navigation that are relevant to investigators at different career stages within major academic health center settings. - Articulate emerging opportunities and future directions for family medicine research, including implications for trainees, interdisciplinary teams, and research infrastructure in high-intensity academic settings.https://cassyni-user-files-prod.s3.amazonaws.com/HTnno3J1M5xytJVQzCxNP8 https://cassyni.com/slides/outline/AbSMFLJ1spt6RKSobgAgjf https://cassyni.com/events/AbSMFLJ1spt6RKSobgAgjf/abstract https://cassyni-user-files-prod.s3.amazonaws.com/2KmDWVjnjnHbMR3NsmMXY2 https://cassyni.com/events/AbSMFLJ1spt6RKSobgAgjf?videoPreview=1 Will You Pay with Face? Drivers to Trial Facial Recognition Payment Technologynohttps://cassyni.com/events/AbSMFLJ1spt6RKSobgAgjf?videoPreview=12022-06-28T23:00:00+00:003143.56Business SchoolThe adoption of facial recognition payment (FRP) technology faces significant consumer acceptance challenges, particularly with systems requiring data storage at retailer locations, due to privacy and security concerns. This study explores the drivers influencing consumers' willingness to trial FRP, focusing on the under-researched pre-trial stages. A systematic literature review identified limited prior work, primarily focused on adoption intention with mixed results based on technology acceptance models. To address this, two studies were conducted: qualitative in-depth interviews with 20 Australian citizens and a quantitative survey involving over 700 Australian citizens. Findings indicate low consumer awareness of FRP, with only 34% having heard of it and 10% having used it, predominantly via mobile device access rather than retailer-based payment. Security concerns consistently rated high across various purchase scenarios. A multi-stage pre-trial process was identified—Knowledge, Interest, Information Search, Affect/Trust, and Trialing Intention—each influenced by distinct drivers. For instance, Word of Mouth and news influence knowledge, while retailer support impacts interest and information search. Trust in retailers and social image affect affect/trust, with previous experience and social presence impacting trialing intention. Younger consumers (under 45) exhibit higher trust and are more susceptible to social influence. Implications suggest retailers should foster consumer knowledge through targeted communication, build strategic alliances, and initially focus on mobile-based FRP solutions to mitigate security concerns and guide consumers through the pre-trial journey.https://cassyni-user-files-prod.s3.amazonaws.com/2KmDWVjnjnHbMR3NsmMXY2 https://cassyni.com/slides/outline/J1C34DWms47f4Nffr7xrnH https://cassyni.com/events/J1C34DWms47f4Nffr7xrnH/abstract https://cassyni-user-files-prod.s3.amazonaws.com/EXkjdhUfkhyXRmXTrbZQ1c https://cassyni.com/events/J1C34DWms47f4Nffr7xrnH?videoPreview=1 Extrinsic geometry and edge states in topological crystalline insulatorsnohttps://cassyni.com/events/J1C34DWms47f4Nffr7xrnH?videoPreview=12025-06-16T07:00:00+00:002076.56ETOPIMThis analysis addresses the geometric response and boundary phenomena in higher-order topological crystalline insulators, focusing on the interplay between bulk topology, boundary states, and extrinsic geometry. The study begins with the characterization of corner states in two-dimensional systems exhibiting fourfold rotational symmetry, exemplified by the quadrupole insulator model, where fractional corner charges (e/2) emerge as a filling anomaly despite the absence of symmetry-protected zero-energy modes. The bulk-boundary correspondence is elucidated through the introduction of disclination defects acting as sources of curvature, which bind charges opposite to those localized at corners. To generalize beyond lattice-specific descriptions, an effective continuum field theory is developed using a first-order formalism with frame fields and spin connections to encode curvature. The effective action incorporates gauge-invariant terms including the Chern-Simons and Wen-Zee terms, capturing electromagnetic and geometric responses. Crucially, the presence of boundaries breaks gauge invariance, necessitating boundary modes or mass terms to restore it. By coupling boundary modes to extrinsic curvature—quantified via the angle between bulk frames and boundary tangent vectors—mass terms can gap out edge states without breaking symmetries, yielding a boundary action (Gromov-Jensen-Abanov) that predicts charge accumulation at points of extrinsic curvature such as corners. This framework extends to curved manifolds, linking total excess charge to the Euler characteristic. A continuum k·p perturbation approach further demonstrates that spatially dependent mass terms respecting rotational symmetry produce quantized boundary charges determined by winding numbers modulo the rotation order. These results establish extrinsic geometry as a fundamental factor in the boundary physics of topological crystalline insulators, providing a universal description of corner charges and their relation to bulk curvature and symmetry, with implications for designing and interpreting topological phases beyond idealized lattice models.https://cassyni-user-files-prod.s3.amazonaws.com/EXkjdhUfkhyXRmXTrbZQ1c https://cassyni.com/slides/outline/LUS4HdkQ4Lt9RK9EPosVWD https://cassyni.com/events/LUS4HdkQ4Lt9RK9EPosVWD/abstract https://cassyni-user-files-prod.s3.amazonaws.com/XZr5THNZUzA5AEUjUZsRCJ https://cassyni.com/events/LUS4HdkQ4Lt9RK9EPosVWD?videoPreview=1 Class ”A” Topological Acoustic Crystals: Capturing the Hofstadter Butterfly and Identifying Bulk and Edge Modes in a Coupled Resonator Latticenohttps://cassyni.com/events/LUS4HdkQ4Lt9RK9EPosVWD?videoPreview=12025-06-17T05:00:00+00:00977.44ETOPIMThis study presents the design and analysis of a bilayer acoustic metamaterial classified as a Class A topological insulator, characterized by the absence of time-reversal, particle-hole, and chiral symmetries. The metamaterial consists of coupled resonators modeled via a tight-binding quantum Hamiltonian, translated into a classical acoustic framework. Numerical simulations using COMSOL Multiphysics focus on the fundamental acoustic mode near 947 Hz, ensuring mode isolation. A 5×5 bilayer lattice of resonators is employed to investigate eigenmodes and their spatial distributions. By varying a phase parameter θ from 0 to π, the system reproduces the Hofstadter butterfly spectrum, revealing bulk and edge modes. Due to computational limitations in simulating large lattices required for clear mode separation, a model-based supervised machine learning approach is developed to map and refine the Hamiltonian predictions. High-performance computing resources enable COMSOL simulations of larger 9×9 lattices, confirming strong agreement with machine learning results across 162 modes spanning 944 to 956 Hz. Experimental validation is conducted using 3D-printed resonators connected by soft silicon wires, with pointwise acoustic measurements demonstrating well-localized edge modes robust against defects. The study highlights the interplay of analytical modeling, numerical simulation, machine learning, and experiment in capturing topological phenomena in acoustic systems, advancing potential applications in noise-resistant communication and sound-based computing.https://cassyni-user-files-prod.s3.amazonaws.com/XZr5THNZUzA5AEUjUZsRCJ https://cassyni.com/slides/outline/UsTL5FkKX8J8aeVhTfCYj7 https://cassyni.com/events/UsTL5FkKX8J8aeVhTfCYj7/abstract https://cassyni-user-files-prod.s3.amazonaws.com/3Y435VQXaFk9rQtLFVghYa https://cassyni.com/events/UsTL5FkKX8J8aeVhTfCYj7?videoPreview=1 Breakdown of conventional topological state prediction in one-dimensional latticesnohttps://cassyni.com/events/UsTL5FkKX8J8aeVhTfCYj7?videoPreview=12025-06-18T03:00:00+00:001949.0ETOPIMTopological phononic crystals (PnCs), a special class of PnCs with unique wave manipulation capabilities, have garnered significant attention over the past decade. Drawing parallels to topological insulators (TIs) in quantum physics—where a topological invariant categorizes materials or structures based on their conductive states—mechanical systems also exhibit topological invariants. These invariants are derived from the spectral evolution of eigenvectors (or mode shapes) through unit cell analysis, determining the number and types of topologically protected domain-wall states (TPDWSs) that confine phonon modes both statically and dynamically. This relationship is commonly referred to as the bulk-edge correspondence. In this talk, I will present theoretical and experimental evidence demonstrating that the number of TPDWSs in a mechanical Su-Schrieffer-Heeger (SSH) model can exceed the winding number prediction when beyond-nearest-neighbor interactions are considered. This reveals a breakdown in the conventional winding number framework. To address this, we employ the Berry connection to accurately characterize the number and spatial features of TPDWSs in SSH systems. Our findings are further supported by Jackiw-Rebbi theory, which confirms that multiple TPDWSs correspond to bulk Dirac cones. These insights advance our understanding of complex network dynamics and provide a generalized framework for predicting TPDWSs in applications involving localized vibrations, such as drug delivery and quantum computing. https://cassyni-user-files-prod.s3.amazonaws.com/3Y435VQXaFk9rQtLFVghYa https://cassyni.com/slides/outline/XLhMJfywiR4cwayG1M7BT3 https://cassyni.com/events/XLhMJfywiR4cwayG1M7BT3/abstract https://cassyni-user-files-prod.s3.amazonaws.com/GtQ2PWcUrxyqVa1TAhpoAe https://cassyni.com/events/XLhMJfywiR4cwayG1M7BT3?videoPreview=1 Topology-driven design of bianisotropic metasurfaces using knotted particlesnohttps://cassyni.com/events/XLhMJfywiR4cwayG1M7BT3?videoPreview=12025-06-19T23:00:00+00:001816.04ETOPIMMetasurfaces usually comprise unit cells based on metal strips or slots combined with dielectrics on a periodic lattice. Such designs have many advantages - they are easy to fabricate and in many cases can be modeled using simple circuit models to predict their response to impinging fields. However, current simulation and fabrication techniques, combined with the extensive analytical and semianalytical modeling techniques utilized in metamaterial research, allow us to exploit a broader range of geometries. One intriguing class of structures are toroidal knots. Knotted wires were shown to have unique scattering and radiation properties. Due to their inherent chirality, they exhibit strongly asymmetric radiation and nearly optimal cross-polarization components. They are characterized by two indices, p, q - the number of revolutions the wire experiences around each center (torus center, and torus cross-section), as shown in Fig. 1. When arranged into a 2D knotted particle metasurface with a proper choice of knot features, one can achieve various electromagnetic wavefront manipulations, ranging from near-optimal polarization rotation to anomalous refraction. Here, we start by relating the knot topology to its functionality, focusing on perfectly matched polarization rotation. We show a family of knotted particles suitable for this task, related by their p, q parameters. We provide simple, analytically derived rules to adjust the knot geometry to obtain a balanced, matched operation that allows for a streamlined design process that does not require numerical optimization. Our model, relying on simplifying assumptions regarding the current distribution in each knotted wire, is then validated using full-wave simulations, which allow us to extract the scattering parameters and the actual current distribution. The results are used to extract the knot polarizability, and the surface susceptibilities, exhibiting the chiral properties. We show two possibilities for implementation: one that utilizes advanced 3D printing, combining conducting materials and dielectrics, and the other that leverages a simplified, flat design for suitable for PCB fabrication.https://cassyni-user-files-prod.s3.amazonaws.com/GtQ2PWcUrxyqVa1TAhpoAe https://cassyni.com/slides/outline/78vk3BHECyvimuDR5Zot2h https://cassyni.com/events/78vk3BHECyvimuDR5Zot2h/abstract https://cassyni-user-files-prod.s3.amazonaws.com/WRUoaUNM9zdtgHQjBz2cHU https://cassyni.com/events/78vk3BHECyvimuDR5Zot2h?videoPreview=1 Observed and dark diversity of plants linked to microbes and humansnohttps://cassyni.com/events/78vk3BHECyvimuDR5Zot2h?videoPreview=12025-07-10T12:00:00+00:001796.04NonePlant diversity ensures the functioning of terrestrial ecosystems, but it varies naturally across regions and ecosystem types. If we know how many ecologically suitable species are absent and form the dark diversity at a particular site, we can infer ecosystem conditions. Dark diversity cannot be observed directly, but it can be estimated. We have shown that in regions with a larger human impact, natural plant communities have relatively larger dark diversity. This alarming finding was not evident when only observed diversity was used. Dark diversity informs nature conservation since it includes more sensitive species and reacts rapidly to land-use changes. Linking dark diversity with species traits and site conditions can reveal causes of why suitable species tend to be absent and set targets for ecological restoration. Diverse vegetation promotes soil biota. Recent evidence is showing that human health is promoted through the connections to biodiversity, particularly soil microbes. We have found that children living closer to natural vegetation have a lower chance of having allergies. In summary, the diversity of plants and microbes are both dependent on human activities but also contribute significantly to our well-being, and dark diversity is allowing us to decipher these relationships. https://cassyni-user-files-prod.s3.amazonaws.com/WRUoaUNM9zdtgHQjBz2cHU https://cassyni.com/slides/outline/ho6XfATNwqeP2yBUep63F https://cassyni.com/events/ho6XfATNwqeP2yBUep63F/abstract https://cassyni-user-files-prod.s3.amazonaws.com/M9jatCxc1LqpGfpaQZyWar https://cassyni.com/events/ho6XfATNwqeP2yBUep63F?videoPreview=1 Multispecies Wasserstein Gradient Flowsnohttps://cassyni.com/events/ho6XfATNwqeP2yBUep63F?videoPreview=12025-07-24T19:00:00+00:003599.64AI Institute in Dynamic SystemsWe present a novel notion of \lambda-monotonicity for an n-species system of Wasserstein-2 gradient flows, proving convergence to the unique Nash equilibrium of the associated energies. This extends known zero-sum results in infinite-dimensional game theory to the general-sum setting. We provide a number of examples of monotone coupled gradient flow systems, including cross-diffusion, gradient flows with potentials, nonlocal interaction, linear and nonlinear diffusion, and min-max systems, and draw connections to a class of mean-field games. Numerically, we demonstrate convergence of a four-player economic model for service providers and strategic users competing in a market, and a degenerately monotone game.https://cassyni-user-files-prod.s3.amazonaws.com/M9jatCxc1LqpGfpaQZyWar https://cassyni.com/slides/outline/EYgRr4VzCDAL6BCWF7VnMb https://cassyni.com/events/EYgRr4VzCDAL6BCWF7VnMb/abstract https://cassyni-user-files-prod.s3.amazonaws.com/GFUTv8qntUtrVaYYzvz1c https://cassyni.com/events/EYgRr4VzCDAL6BCWF7VnMb?videoPreview=1 Diverse knowledge and open infrastructuresnohttps://cassyni.com/events/EYgRr4VzCDAL6BCWF7VnMb?videoPreview=12025-07-02T08:00:00+00:004790.32The seminar addresses the critical interplay between diverse knowledge systems and open infrastructures within the evolving landscape of metascience, emphasizing the necessity of transparency, inclusivity, and robust data practices to enhance scientific excellence and societal impact. Key contributions include insights from the European Research Council (ERC), which actively monitors and evaluates its funding strategies to support frontier research while acknowledging challenges such as panel conservatism against interdisciplinary proposals and the need for improved metrics to identify breakthrough science. The ERC promotes open data access and collaborates with external researchers to refine impact assessment. The Canadian Institutes of Health Research (CIHR) highlights the integration of diverse perspectives—including indigenous knowledge and equity considerations—into a newly defined inclusive research excellence framework, alongside initiatives to support underrepresented groups and community-led research. France’s national open science efforts reveal progress in open access and data sharing but identify persistent disciplinary diversity and resistance as obstacles, motivating the proposal of the Global Research Initiative on Open Science (GRIOS) to foster evidence-based open science policies internationally. UNESCO situates open science as a global public good, advocating for open infrastructures that enable equitable participation worldwide and embedding diverse knowledge systems within science governance. Finally, meta-science’s reliance on data and publishing infrastructures is critically examined, revealing limitations in access, transparency, and inclusiveness that constrain the field’s capacity to provide comprehensive, unbiased insights. The seminar underscores the urgent need for open, interoperable infrastructures and collaborative frameworks to realize science’s full potential as a public good.https://cassyni-user-files-prod.s3.amazonaws.com/GFUTv8qntUtrVaYYzvz1c https://cassyni.com/events/G1CVA1AMyBaZcMtcW4JAyK/seminar/qa https://cassyni.com/slides/outline/G1CVA1AMyBaZcMtcW4JAyK https://cassyni.com/events/G1CVA1AMyBaZcMtcW4JAyK/abstract https://cassyni-user-files-prod.s3.amazonaws.com/PTVSb19LGA98WkFGf6eZaE https://cassyni.com/events/G1CVA1AMyBaZcMtcW4JAyK?videoPreview=1 Staged-Combustion-Cycle Rocket Engines for Space Transportationnohttps://cassyni.com/events/G1CVA1AMyBaZcMtcW4JAyK?videoPreview=12026-09-15T14:00:00+00:003622.44AIAA JournalFirst proposed by Alexey Isaev in 1949, staged-combustion-cycle (SCC) rocket engines have been extensively developed and deployed in a wide range of space transportation programs worldwide. Notable examples include the RD-120 and RD-170 engine series developed in Russia (formerly the Soviet Union), the YF-100 engine in China, and the Space Shuttle Main Engine, SpaceX’s Raptor engine, and Blue Origin’s BE-4 engine in the United States. In SCC engines, the propellants pass through multiple combustion chambers and react in stages. Among all thermodynamic cycles for liquid-propellant rocket engines, the SCC offers the highest performance while providing superior reliability, operational robustness, and mission flexibility. This seminar will begin with a historical overview of the evolution of SCC engine technology around the world. It will then examine the technology foundations of the three principal SCC engine architectures: the oxidizer-rich preburner cycle, the fuel-rich preburner cycle, and the full-flow staged-combustion cycle. The operating characteristics and key design considerations of each architecture will be discussed in the context of different propellant combinations and power-cycle configurations. The seminar will further explore the underlying physical processes and governing mechanisms, emphasizing their roles in engine performance and design optimization. Finally, key challenges associated with advanced materials, manufacturing, reliability, and robustness will be addressed.https://cassyni-user-files-prod.s3.amazonaws.com/PTVSb19LGA98WkFGf6eZaE https://cassyni.com/events/MSMkn9o2CabgtFAooFUWZK/seminar/qa https://cassyni.com/slides/outline/MSMkn9o2CabgtFAooFUWZK https://cassyni.com/events/MSMkn9o2CabgtFAooFUWZK/abstract https://cassyni-user-files-prod.s3.amazonaws.com/BCt11cAMQpzH2yhwJ6EfyY https://cassyni.com/events/MSMkn9o2CabgtFAooFUWZK?videoPreview=1 Micro Aerial Vehicles in the Age of Physical AI: From GPS-Denied Mapping to Intent-Driven Field Autonomynohttps://cassyni.com/events/MSMkn9o2CabgtFAooFUWZK?videoPreview=12026-07-28T15:00:00+00:003731.36AIAA JournalMicro aerial vehicles are emerging as powerful platforms for embodied autonomy in complex, GPS-denied, and hard-to-access environments. Their small size and agility allow them to operate under forest canopy, between tree lines, inside buildings, and in other cluttered settings where larger systems cannot go. At the same time, their severe constraints in sensing, computation, communication, energy, and payload make them a demanding testbed for physical AI: intelligence must be tightly coupled to perception, planning, control, and the dynamics of flight. In this talk, I will describe our work on intelligent micro aerial vehicles for autonomous operation in complex field environments. I will discuss the abstractions, architectures, and algorithms that enable robots to estimate state, reason about free space, plan dynamically feasible trajectories, and build semantic-metric maps in GPS-denied environments. I will also describe recent advances in learning-guided active perception, semantic mapping, air-ground collaboration, and language-specified missions, showing how MAVs can move beyond coverage and mapping toward task-driven information gathering. The talk will highlight applications in precision agriculture, forestry, infrastructure inspection, and search in unknown environments, with examples of autonomous flight under forest canopy, between tree rows, and in cluttered indoor and outdoor settings. I will close with a discussion of research needs for the next generation of MAVs, including scalable representations for physical AI, active perception with task-level value of information, safe real-time planning under uncertainty, onboard foundation models under size-weight-power constraints, resilient operation with degraded sensing and communication, and verification methods for field-deployed autonomy. https://cassyni-user-files-prod.s3.amazonaws.com/BCt11cAMQpzH2yhwJ6EfyY https://cassyni.com/events/LT4YgnVyKfVYDVLohH1BkR/seminar/qa https://cassyni.com/slides/outline/LT4YgnVyKfVYDVLohH1BkR https://cassyni.com/events/LT4YgnVyKfVYDVLohH1BkR/abstract https://cassyni-user-files-prod.s3.amazonaws.com/5vZiNhau533DVyokkG8mSW https://cassyni.com/events/LT4YgnVyKfVYDVLohH1BkR?videoPreview=1 Two Talks by Visiting Scholars - L2 Reading Research; L2 Vocabulary Acquisitionnohttps://cassyni.com/events/LT4YgnVyKfVYDVLohH1BkR?videoPreview=12026-02-10T00:00:00+00:003630.44Linguistics and Applied Language StudiesResearch in second language (L2) reading strategies highlights challenges in learner metacognitive awareness and efficient text processing. One line of study, employing eye-tracking and page navigation, investigated L2 learners' behaviors across diverse reading tasks. Findings indicated that many students inefficiently focused on textual details or irrelevant content, with few employing strategic previewing or content-skipping. An intervention demonstrating global processing principles significantly improved reading efficiency and recall. Further analysis of vocabulary coping strategies revealed that a majority (63%) of dictionary users did not complete sentence reading before look-up. Conversely, an intervention promoting reading-first before machine translation (MT) use showed that most students (90%) finished sentences and reread (42%), improving vocabulary acquisition and comprehension. Another stream of research explored the non-linear nature of L2 vocabulary acquisition, differentiating 'learning burden' (effort required) from 'lexical decay' (forgetting despite continued exposure). Two studies, using a frequency-based methodology, examined factors influencing these phenomena. The first found L1 equivalents reduced both learning burden and decay compared to L2 definitions. The second showed bimodal (spoken and written) presentation lowered learning burden but not decay. Associative memory capacity predicted lower learning burden, but language aptitude did not correlate with decay. Both investigations confirmed a greater likelihood of decay for words with higher learning burden. Collectively, this research underscores the intricate interplay of cognitive and pedagogical factors in L2 reading and vocabulary, advocating for data-driven instruction tailored to promote strategic competence and retention.https://cassyni-user-files-prod.s3.amazonaws.com/5vZiNhau533DVyokkG8mSW https://cassyni.com/events/6cudPePH2qz4aJt6nben1b/seminar/qa https://cassyni.com/slides/outline/6cudPePH2qz4aJt6nben1b https://cassyni.com/events/6cudPePH2qz4aJt6nben1b/abstract https://cassyni-user-files-prod.s3.amazonaws.com/2iYJtZHZnxec4enjZrRLzz https://cassyni.com/events/6cudPePH2qz4aJt6nben1b?videoPreview=1 Why Headaches Are Everyone’s Business: Health, Work, and Inequality on the Global Stagenohttps://cassyni.com/events/6cudPePH2qz4aJt6nben1b?videoPreview=12026-03-27T12:00:00+00:003507.96The Journal of Headache and PainMigraine and headache disorders are among the world’s most common yet overlooked health challenges, with profound effects on wellbeing, productivity, and equality. This multi‑regional webinar brings together experts from around the globe to explore how reframing migraine as a major global health issue can drive progress toward the UN Sustainable Development Goals (SDGs).https://cassyni-user-files-prod.s3.amazonaws.com/2iYJtZHZnxec4enjZrRLzz https://cassyni.com/slides/outline/F3L2tk9WdfiP5wjPqYnacu https://cassyni.com/events/F3L2tk9WdfiP5wjPqYnacu/abstract https://cassyni-user-files-prod.s3.amazonaws.com/C51paSz8UKx1RL3LeE8R7U https://cassyni.com/events/F3L2tk9WdfiP5wjPqYnacu?videoPreview=1 Harnessing agri-food system microbiomes for sustainability and human healthnohttps://cassyni.com/events/F3L2tk9WdfiP5wjPqYnacu?videoPreview=12025-09-11T14:00:00+00:005270.04Frontiers in Science#### Hidden connections between our food, health, and planet Explore how omics-based mapping of interconnected microbial networks is transforming our understanding of agri-food system microbiomes. Learn how this could inform targeted interventions to restore and protect them. The work, published in a [Frontiers in Science lead article](https://www.frontiersin.org/journals/science/articles/10.3389/fsci.2025.1575468/abstract), is driving the development of microbiome-based solutions to enhance animal, human, and environmental health. The aim is to help to create more sustainable food systems globally—ultimately boosting both human and planetary health. Join the article authors for an in-depth discussion on why an integrated approach—uniting scientists, innovators, regulators, educators, and everyday consumers—is essential to confront threats such as the climate crisis, antibiotic overuse, and pesticide reliance, all of which erode microbiome health within the food system. [Click here to register](https://events.frontiersin.org/agrifood-system-microbiomes/Cassyni). https://cassyni-user-files-prod.s3.amazonaws.com/C51paSz8UKx1RL3LeE8R7U https://cassyni.com/slides/outline/DYEh4t5boW5J2ycqtwtEHK https://cassyni.com/events/DYEh4t5boW5J2ycqtwtEHK/abstract https://cassyni-user-files-prod.s3.amazonaws.com/K2W2TAhdHTiuyHxDpcNAEJ https://cassyni.com/events/DYEh4t5boW5J2ycqtwtEHK?videoPreview=1 Technologies and policies for a sustainable energy future, TED talknohttps://cassyni.com/events/DYEh4t5boW5J2ycqtwtEHK?videoPreview=12014-02-22T09:00:00+00:001118.52 School of Public PolicyThe challenge of meeting rising global energy demands—particularly in rapidly developing regions such as Asia, India, China, and the Middle East—while avoiding catastrophic climate change necessitates a fundamental shift from fossil fuels to more sustainable energy sources and improved energy efficiency. Current projections indicate a doubling of worldwide energy consumption over the next fifty years, with the United States’ share declining despite its recent growth in natural gas and oil production. Climate models suggest that business-as-usual policies could lead to a global temperature increase of approximately 6°C, far exceeding the 2°C guardrail targeted by international agreements like the Copenhagen Accord. However, existing infrastructure and emissions commitments limit the potential for meeting this target, making a 3.5°C increase more plausible under current policy trajectories. Energy efficiency improvements have already emerged as the largest energy resource in the U.S., effectively halving projected consumption compared to two decades ago, though offshoring of energy-intensive production complicates national accounting. Technological advances such as advanced lighting, communicating thermostats, and dynamic pricing offer cost-effective opportunities for further efficiency gains. Renewable energy currently accounts for about 5% of U.S. electricity generation, expected to rise to 12% in two decades, with policy instruments like state-level renewable portfolio standards driving adoption. Yet, the heterogeneity of state policies poses challenges for scaling renewables nationally, prompting debate over federal standardization versus preserving state-level innovation. Local initiatives demonstrate promising leadership in renewable adoption and energy transparency, underscoring a multi-scalar approach to achieving a sustainable energy future.https://cassyni-user-files-prod.s3.amazonaws.com/K2W2TAhdHTiuyHxDpcNAEJ https://cassyni.com/slides/outline/LwzNsmJMnjJrg2qi9PgQKw https://cassyni.com/events/LwzNsmJMnjJrg2qi9PgQKw/abstract https://cassyni-user-files-prod.s3.amazonaws.com/ByJnA3hvNJVVxLZuC6q9X4 https://cassyni.com/events/LwzNsmJMnjJrg2qi9PgQKw?videoPreview=1 AAHCI Ignite! Talks: Artificial Intelligence in Health Professions Educationnohttps://cassyni.com/events/LwzNsmJMnjJrg2qi9PgQKw?videoPreview=12025-05-08T08:00:00+00:007017.36AAMCThe [AAHCI Student Leadership Initiative (ASLI)](https://www.aamc.org/learn-network/affinity-groups/aahci/aahci-student-leadership-initiative-asli) was created to challenge health profession students at academic health centers to share new ideas or innovative programs tackling key topics in health professions education. Students at AAHCI member institutions were invited to submit proposal abstracts for the 2025 ASLI theme: “AI in Health Professions Education,” and a committee review process resulted with finalists across the globe. The student authors of the selected proposals present their ideas in this webinar. This webinar is part of the Artificial Intelligence in Academic Medicine Webinar Series, hosted by the AAMC. It explores critical concepts, the current landscape, and practical strategies drawn from various perspectives and institutions to support you in navigating the evolving world of AI in academic medicine. For more information, see [the complete series webpage](https://www.aamc.org/about-us/mission-areas/medical-education/artificial-intelligence-ai-academic-medicine-webinar-series). https://cassyni-user-files-prod.s3.amazonaws.com/ByJnA3hvNJVVxLZuC6q9X4 https://cassyni.com/events/RtDpJw8dZ4WiAbPDua5Fch/seminar/qa https://cassyni.com/slides/outline/RtDpJw8dZ4WiAbPDua5Fch https://cassyni.com/events/RtDpJw8dZ4WiAbPDua5Fch/abstract https://cassyni-user-files-prod.s3.amazonaws.com/JtVfDaty1wV34pPeEWXZdQ https://cassyni.com/events/RtDpJw8dZ4WiAbPDua5Fch?videoPreview=1 Thieme Cheminar: Boron as a linchpin in catalysisnohttps://cassyni.com/events/RtDpJw8dZ4WiAbPDua5Fch?videoPreview=12026-04-14T12:00:00+00:007231.32Thieme GroupJoin us for the Thieme Cheminar “Boron as a linchpin in catalysis” Tuesday, April 14, 2026, 14:00 (CET) This special online event, brought to you by SYNTHESIS Journal, highlights the key importance of boron chemistry in catalysis. Boron’s unique ability to modulate reactivity, facilitate challenging bond formations, and serve as a versatile platform for catalyst design has elevated it to a central position in modern organic synthesis. The program will feature outstanding talks from leading researchers in the field: 🔹 Prof. Hirohisa Ohmiya (Kyoto University, Japan) 🔹 Prof. Elena Fernández (Universitat Rovira i Virgili, Spain) 🔹 Prof. James Morken (Boston College, USA) The session will be chaired by Prof. Martin Oestreich, Editor-in-Chief of SYNTHESIS Journal. Do not miss this unique opportunity to explore cutting‑edge advances in boron chemistry and engage with the leading voices shaping the future of organic synthesis! https://cassyni-user-files-prod.s3.amazonaws.com/JtVfDaty1wV34pPeEWXZdQ https://cassyni.com/slides/outline/PREQ7BXyz25M2yKGh5b33s https://cassyni.com/events/PREQ7BXyz25M2yKGh5b33s/abstract https://cassyni-user-files-prod.s3.amazonaws.com/VoqoPxB3AFKuuLDvd4EfZG https://cassyni.com/events/PREQ7BXyz25M2yKGh5b33s?videoPreview=1 Global Internet, digital authoritarianism and fragmentationnohttps://cassyni.com/events/PREQ7BXyz25M2yKGh5b33s?videoPreview=12025-04-24T08:00:00+00:00602.68 School of Public PolicyThe evolving landscape of Internet governance has expanded from a narrow focus on technical identifiers, such as domain names and IP addressing, to encompass the broader digital ecosystem, including data governance, software, and hardware components. This shift reflects the increasing securitization and geopolitical significance of the digital economy, exemplified by measures like U.S. sanctions on semiconductors. Despite this broadening, a persistent tension remains between multilateral, sovereignty-based governance and multi-stakeholder models led by private sector and civil society actors. This tension manifests in areas such as privacy regulation, content moderation, and encryption, where no global consensus exists, resulting in a fragmented jurisdictional landscape. While the Internet’s technical protocols maintain global compatibility, states increasingly impose divergent policies, leading to jurisdictional fragmentation without complete disconnection from the global network—even authoritarian regimes remain connected due to economic and strategic imperatives. Multilateral initiatives, such as the UN’s Global Digital Compact and the Declaration for the Future of the Internet, face challenges due to conflicting national interests and values, particularly between liberal democracies and authoritarian states. The multi-stakeholder governance model’s resilience depends on liberal democratic governments recognizing and supporting bottom-up, community-driven coordination and policy development, which empowers business and civil society alongside states. This approach is crucial for maintaining a globally interoperable digital ecosystem amid rising geopolitical fragmentation and digital authoritarianism.https://cassyni-user-files-prod.s3.amazonaws.com/VoqoPxB3AFKuuLDvd4EfZG https://cassyni.com/slides/outline/KxhAnQ1JupCi1H1i3RD5X3 https://cassyni.com/events/KxhAnQ1JupCi1H1i3RD5X3/abstract https://cassyni-user-files-prod.s3.amazonaws.com/BPVG96SpqxPDngbfZHk8G6 https://cassyni.com/events/KxhAnQ1JupCi1H1i3RD5X3?videoPreview=1 Economic Mobility as a Tool for a Sustainable Futurenohttps://cassyni.com/events/KxhAnQ1JupCi1H1i3RD5X3?videoPreview=12021-09-30T08:00:00+00:003971.04 School of Public PolicyThis seminar explores economic mobility as a critical mechanism for fostering a sustainable future, emphasizing its role in enhancing resilience, inclusivity, and long-term economic vitality. Economic mobility is framed as the capacity for individuals to improve their economic status through effort and access to resources, a principle closely linked to the Federal Reserve’s dual mandate of stable prices and maximum employment. The discussion highlights persistent disparities affecting women, ethnic minorities, and certain geographic regions, underscoring the need to broaden economic participation to unlock untapped potential. The Federal Reserve Bank of Atlanta’s strategic focus on economic mobility and resilience involves research, convening stakeholders, advising policymakers, and promoting effective workforce programs, despite legal constraints limiting direct targeted investments. The seminar addresses the impact of the COVID-19 pandemic, which disproportionately affected lower-wage workers and small businesses, and the importance of sustained policy support to prevent permanent setbacks in vulnerable communities. Recent changes in monetary policy strategy aim to support more inclusive and durable job growth by allowing employment to run “hot” until inflation materializes. The complexities of emerging financial technologies, including central bank digital currencies and cryptocurrencies, are examined in relation to privacy, regulatory implications, and economic stability. Additionally, challenges of affordable housing and gentrification are discussed as barriers to mobility, with emphasis on local policy and income growth as complementary solutions. The seminar concludes with reflections on the Southeast U.S. economy’s uneven growth and the evolving nature of work, highlighting the need for workforce adaptation to automation and the promotion of opportunity occupations that offer sustainable wages without extensive formal education.https://cassyni-user-files-prod.s3.amazonaws.com/BPVG96SpqxPDngbfZHk8G6 https://cassyni.com/slides/outline/WLJrkkbL8Rq8XnJr4X9yCZ https://cassyni.com/events/WLJrkkbL8Rq8XnJr4X9yCZ/abstract https://cassyni-user-files-prod.s3.amazonaws.com/3xJpsRffxoQMZSv8NoxSQE https://cassyni.com/events/WLJrkkbL8Rq8XnJr4X9yCZ?videoPreview=1 Heed Neglect to Disrupt Child Maltreatment: Implications for Preventionnohttps://cassyni.com/events/WLJrkkbL8Rq8XnJr4X9yCZ?videoPreview=12022-01-19T09:00:00+00:003561.96 School of Public PolicyChild maltreatment remains a pervasive public health issue in the United States, with neglect constituting approximately 75% of all reported cases. Despite significant declines in physical and sexual abuse rates over recent decades, neglect rates have remained stagnant, and fatalities involving neglect have increased. This persistence is attributed to the complex interplay between neglect and poverty, complicating the identification and prevention of true neglect cases. Traditional child protective services (CPS) interventions, often focused on psychosocial therapies, are limited in addressing neglect because it frequently results from omissions linked to economic hardship rather than intentional harmful behaviors. The analysis emphasizes a public health framework that prioritizes understanding and addressing the root causes of neglect through macro-level social and economic policies. Empirical evidence demonstrates that policies increasing family income and time—such as minimum wage increases, earned income tax credit expansions, child support enforcement, and paid family leave—consistently reduce neglect reports and foster care entries by approximately 7–10%. Mechanisms include reduced maternal employment hours, particularly weekend shifts, and decreased harsh parenting behaviors. These findings suggest that neglect prevention requires a systemic approach integrating diverse social safety net programs (e.g., food assistance, housing support, healthcare, education) to alleviate poverty-related stressors. The study advocates for child well-being metrics, including neglect rates, to be central considerations in policy evaluation, shifting responsibility beyond CPS to encompass broader economic and social policy domains. This approach holds promise for disrupting persistent neglect and improving child and family outcomes.https://cassyni-user-files-prod.s3.amazonaws.com/3xJpsRffxoQMZSv8NoxSQE https://cassyni.com/slides/outline/WpxToSErZtPBXYqjexSmTs https://cassyni.com/events/WpxToSErZtPBXYqjexSmTs/abstract https://cassyni-user-files-prod.s3.amazonaws.com/6h3sqW1w3fJYHC6B8ossRQ https://cassyni.com/events/WpxToSErZtPBXYqjexSmTs?videoPreview=1 Panel Discussion: International Security and Human Rightsnohttps://cassyni.com/events/WpxToSErZtPBXYqjexSmTs?videoPreview=12015-10-09T08:00:00+00:004606.48 School of Public PolicyThe panel discussion on international security and human rights critically examined the complex interplay between internet censorship, free speech, and information technology within domestic and international contexts. Emphasizing a nuanced perspective, the analysis highlighted that while free expression and digital communication promote democracy and human rights, they can also facilitate social instability, conflict, and misinformation, sometimes exacerbating violence and governance breakdown, as evidenced in cases like Libya, Syria, and Ukraine. The discourse underscored the evolving nature of censorship—from overt blocking to subtler battles over legitimacy and information credibility—illustrated by the Turkish experience where social media circumvented traditional media censorship but engendered challenges in verifying information authenticity amid state-sponsored disinformation. The panelists advocated for a multidisciplinary approach integrating technological, social, and political insights to address censorship effectively. Key recommendations included prioritizing measurement and contextual analysis of censorship practices over solely developing circumvention tools, recognizing the importance of reputational and verification mechanisms alongside anonymity, and embedding ethical considerations in technology design. The discussion also stressed the need for technologists to engage deeply with policy processes and local sociopolitical realities to create tools aligned with users’ actual needs, such as secure everyday communication platforms and fast VPNs for activists. Ultimately, the dialogue called for collaborative efforts bridging technical and social sciences to foster an internet environment that balances free expression with social stability and legitimacy, acknowledging the ongoing, iterative nature of this challenge.https://cassyni-user-files-prod.s3.amazonaws.com/6h3sqW1w3fJYHC6B8ossRQ https://cassyni.com/events/F1xXHtu5tzKmt7vy91vGs7/seminar/qa https://cassyni.com/slides/outline/F1xXHtu5tzKmt7vy91vGs7 https://cassyni.com/events/F1xXHtu5tzKmt7vy91vGs7/abstract https://cassyni-user-files-prod.s3.amazonaws.com/PEmCd6cw7D7poXb6AALvfg https://cassyni.com/events/F1xXHtu5tzKmt7vy91vGs7?videoPreview=1 The flying dolphin. Can metamaterials bring passive laminar-flow control from water to air?nohttps://cassyni.com/events/F1xXHtu5tzKmt7vy91vGs7?videoPreview=12026-06-23T13:00:00+00:003858.04MetaMATThe idea that compliant surfaces may passively delay the transition to turbulence can be traced back to the famous “dolphin’s secret” hypothesis by Kramer. Following Gray’s observations of the remarkable swimming performance of dolphins, he suggested that the compliant nature of their skin could help maintain an extended laminar boundary layer and thereby reduce friction drag. Although subsequent studies revealed a much more complex interplay between skin properties, body geometry, and swimming kinematics, this hypothesis initiated decades of research on compliant walls and their interaction with boundary-layer instabilities. This seminar revisits this historical perspective and discusses recent advances in passive flow control through fluid–structure interaction. First, the mechanisms governing the interaction between conventional compliant walls and Tollmien–Schlichting waves in hydrodynamic boundary layers are examined, based on the characterisation framework developed by Pfister _et al._ (2022). The discussion then turns to the use of phononic metamaterials, whose internal architecture enables a precise tailoring of their dynamical response. Recent results demonstrate that such structures can overcome several limitations of conventional compliant walls, suppress detrimental fluid–structure instabilities, and achieve effective attenuation of Tollmien–Schlichting waves in water flows (Fabbiane _et al._, 2025). Finally, the seminar explores the ongoing transition of these concepts from hydrodynamics to aerodynamics, where the much weaker fluid–structure coupling poses fundamental challenges. Two complementary directions are presented: the design of compliant metamaterials with tailored effective properties for aerodynamic applications, and the use of resonant and phononic structures to amplify the interaction between boundary-layer disturbances and structural dynamics. These recent and ongoing developments suggest that metamaterials may provide new opportunities for passive laminar flow control in aerodynamic boundary layers, while raising a number of open questions that remain to be addressed experimentally and theoretically.https://cassyni-user-files-prod.s3.amazonaws.com/PEmCd6cw7D7poXb6AALvfg https://cassyni.com/events/KTpapgEhFUEkVFPALEdHeD/abstract https://cassyni-user-files-prod.s3.amazonaws.com/YEtgzY4xSCiNZzWq33zX3k https://cassyni.com/slides/outline/RPppHv85jrJ78gbW43SyUR https://cassyni.com/events/RPppHv85jrJ78gbW43SyUR/abstract https://cassyni-user-files-prod.s3.amazonaws.com/NmbwVDCouUS6zGua8ENbmg https://cassyni.com/events/RPppHv85jrJ78gbW43SyUR?videoPreview=1 Introducing Intellectual Property for STEM/STEAM Coursesnohttps://cassyni.com/events/RPppHv85jrJ78gbW43SyUR?videoPreview=12021-11-03T09:00:00+00:002484.04 School of Public PolicyThe integration of intellectual property (IP) education into STEM and STEAM curricula addresses the critical role IP plays in the contemporary knowledge economy, where intangible assets underpin innovation and commercial value. Intellectual property encompasses creations of the human mind—ranging from technological inventions and manufacturing processes to artistic works and trade secrets—that receive legal protection and can be managed as property. This broad scope necessitates IP literacy across disciplines, as students in business, liberal arts, engineering, and computer science alike generate and interact with IP in their careers. The seminar highlights Georgia Tech’s interdisciplinary IP certificate program, which requires 12 semester hours and offers courses spanning public policy, law, business, engineering, and liberal arts, designed to prepare students for diverse IP-related careers including patent law, licensing, and policy development. Complementary initiatives include guest lectures and community outreach, ensuring widespread IP awareness. Additionally, the integration of IP concepts into engineering education at Ocean County College exemplifies practical pedagogical approaches: early exposure through design projects, emphasis on IP awareness and management, and experiential learning activities such as logo creation and nondisclosure agreements for trade secret projects. These efforts underscore the importance of embedding IP education to equip students with the knowledge to innovate responsibly, protect their creations, and navigate the legal and economic dimensions of intellectual property in their professional endeavors.https://cassyni-user-files-prod.s3.amazonaws.com/NmbwVDCouUS6zGua8ENbmg https://cassyni.com/slides/outline/D3PjDnpsYX37LeSvPS8cKP https://cassyni.com/events/D3PjDnpsYX37LeSvPS8cKP/abstract https://cassyni-user-files-prod.s3.amazonaws.com/5LEA98dVf6JmcCU3atvgza https://cassyni.com/events/D3PjDnpsYX37LeSvPS8cKP?videoPreview=1 HKBU Digital Project Series on Sun Yat-sen Studiesnohttps://cassyni.com/events/D3PjDnpsYX37LeSvPS8cKP?videoPreview=12023-10-27T06:00:00+00:002075.8Hong Kong Baptist UniversitySpeakers shared their studies on Sun Yat-sen including completed projects and ongoing projects. They also introduced some databases about Sun Yat-sen, such as "Sun Yat-sen Parks in the World", "Pictorial Representations of Sun Yat-sen" and "孫中山首日封", etc.https://cassyni-user-files-prod.s3.amazonaws.com/5LEA98dVf6JmcCU3atvgza https://cassyni.com/slides/outline/68YFVFtcczhEN6Z18jrfnD https://cassyni.com/events/68YFVFtcczhEN6Z18jrfnD/abstract https://cassyni-user-files-prod.s3.amazonaws.com/3P9yRP4TgFiGMW5R8szvtv https://cassyni.com/events/68YFVFtcczhEN6Z18jrfnD?videoPreview=1 AI and Ethics: Considerations for Scholarly Communitiesnohttps://cassyni.com/events/68YFVFtcczhEN6Z18jrfnD?videoPreview=12023-11-03T09:00:00+00:002097.12 School of Public PolicyThis seminar addresses the ethical considerations arising at the intersection of artificial intelligence (AI) and scholarly activities, with particular attention to the implications of generative AI and large language models in research contexts. Central issues include the reliance of AI systems on large datasets obtained through methods such as web scraping, raising concerns about privacy, confidentiality, and data transparency. The potential for bias is examined, highlighting how training data composition and designers’ implicit values can lead to discriminatory or skewed outputs, including language and disciplinary biases. The complexity and opacity of AI systems—often described as the “black box” problem—challenge users’ ability to verify the accuracy and provenance of AI-generated information, complicating trust calibration. Both overtrust, where users attribute capabilities to AI systems they do not possess, and undertrust, where users discount reliable AI outputs, are identified as risks with practical consequences for scholarly work. Additional ethical dimensions include the use of gendered features in AI interfaces, which may influence user trust but also risk perpetuating stereotypes. The emergence of AI-generated identities and authorship raises questions about authenticity, accountability, and research misconduct, particularly regarding plagiarism, falsification, and fabrication. The seminar also surveys responses from professional organizations and academic journals, noting recent policies that preclude AI systems from authorship due to accountability constraints, while acknowledging ongoing debates about appropriate acknowledgment of AI contributions. The discussion underscores the need for collaborative engagement among researchers, librarians, publishers, and other stakeholders to navigate the evolving ethical landscape of AI in scholarship.https://cassyni-user-files-prod.s3.amazonaws.com/3P9yRP4TgFiGMW5R8szvtv https://cassyni.com/slides/outline/8bnGig8EpHTij32ZgRmJW9 https://cassyni.com/events/8bnGig8EpHTij32ZgRmJW9/abstract https://cassyni-user-files-prod.s3.amazonaws.com/8bCArzyqV7p1oBvMB6dtbG https://cassyni.com/events/8bnGig8EpHTij32ZgRmJW9?videoPreview=1 Biophysics in Africa: Structural insights in DNA replication and repairnohttps://cassyni.com/events/8bnGig8EpHTij32ZgRmJW9?videoPreview=12023-10-25T08:00:00+00:004299.44Springer Nature Physics CommunityStructural biology has been the most successful applications of physics to biology, providing atomic information on several thousands of macromolecules and complex macromolecular machines. Among these machines, I have always been fascinated by helicases, a family of proteins that act as molecular motors, using the energy from ATP hydrolysis to move along the DNA and unwind the double helix. Eukaryotic cells contain large amount of DNA that needs to be faithfully copied to ensure genetic continuity, and constantly repaired to counteract the damage caused by normal metabolism and external agents, and helicases are essential tools in dealing with these problems. Some of these proteins are also specialised in dealing with non-canonical structures such as G-quadruplexes and R-loops. We use a combination of biophysical and biochemical techniques to study these fascinating machines and understand their mechanism of action at the atomic level.https://cassyni-user-files-prod.s3.amazonaws.com/8bCArzyqV7p1oBvMB6dtbG https://cassyni.com/slides/outline/G1WLQvq7Q9mZDcZ2eJd2v9 https://cassyni.com/events/G1WLQvq7Q9mZDcZ2eJd2v9/abstract https://cassyni-user-files-prod.s3.amazonaws.com/AFzZFMgs94QMGRp1UMM47Q https://cassyni.com/events/G1WLQvq7Q9mZDcZ2eJd2v9?videoPreview=1 L-H transition studies at JETnohttps://cassyni.com/events/G1WLQvq7Q9mZDcZ2eJd2v9?videoPreview=12024-04-25T06:00:00+00:003684.04Journal of Plasma PhysicsOne of the most beautiful phenomena we observe in tokamaks is the transition between L and H-mode, a clear phase transition. Here we present and discuss results from dedicated L-H transition experiments at JET-ILW [ER Solano et al, Nuclear Fusion 63 (11), 112011, 2023]. Uniquely, we studied the power threshold in plasmas composed of pure Tritium, to be compared with Hydrogen and Deuterium plasmas, D+T mixtures, and H+T mixtures [G. Birkenmeier et al, PPCF 65 (5), 054001, 2023]. We show that critical pressure profiles are required for the L-H transition to occur, and such critical profiles are independent of plasma content, but the power threshold itself depends strongly on isotopic content. PLH is in fact determined by plasma transport characteristics in L-mode. Additionally, in Deuterium plasmas, an analysis of Doppler reflectometer measurements of the edge perpendicular velocity in D and He plasmas shows that there is no critical radial electric field value or critical vExB rotation before the transition [C. Silva et al, Nuclear Fusion 61 (12), 126006, 2021]. Instead, there appears to a vExB profile that is characteristic of the L-mode. The diamagnetic velocity, proportional to ∇p, is a better indicator of proximity to the L-H transition. Together, these results enable us to challenge the widely accepted model of the L-H transition being associated to the stabilisation of electrostatic turbulence by sufficient vExB shear. An alternate model of the L-H transition is presented, based on a magnetisation transition of the plasma.https://cassyni-user-files-prod.s3.amazonaws.com/AFzZFMgs94QMGRp1UMM47Q https://cassyni.com/slides/outline/AaNguQiLa7gUpkJo3PdEvh https://cassyni.com/events/AaNguQiLa7gUpkJo3PdEvh/abstract https://cassyni-user-files-prod.s3.amazonaws.com/8qWyPLobhr64dgZuRsE9s4 https://cassyni.com/events/AaNguQiLa7gUpkJo3PdEvh?videoPreview=1 Biophysics in Africa: Quantum effect, biological context: An introduction to quantum biologynohttps://cassyni.com/events/AaNguQiLa7gUpkJo3PdEvh?videoPreview=12025-07-30T06:00:00+00:004427.32Springer Nature Physics CommunityQuantum biology is an exciting field of research with a pronounced interdisciplinary focus. This lecture will cover a short history of quantum biology before clarifying some of the important concepts in the field and reviewing the different biological contexts in which quantum effects may play a role, which include photosynthesis, enzyme catalysis, DNA mutation, receptor binding, microtubule and mitochondrial function, magnetoreception, regulation of the production of ROS, calcium ion storage and release, and potentially, consciousness.https://cassyni-user-files-prod.s3.amazonaws.com/8qWyPLobhr64dgZuRsE9s4 https://cassyni.com/events/UrPfjLAeDR6WzNwXsDGS9K/abstract https://cassyni-user-files-prod.s3.amazonaws.com/PZEboDAAAXCPe5dkizxBWW https://cassyni.com/slides/outline/6dDUea42TpB4Bs8MtgayBb https://cassyni.com/events/6dDUea42TpB4Bs8MtgayBb/abstract https://cassyni-user-files-prod.s3.amazonaws.com/7sqkCiG4cuJ5NF5aDwRBdp https://cassyni.com/events/6dDUea42TpB4Bs8MtgayBb?videoPreview=1 Why sleep matters for personal and public healthnohttps://cassyni.com/events/6dDUea42TpB4Bs8MtgayBb?videoPreview=12022-01-19T06:00:00+00:003608.48Part of the nonprofit Annual Reviews organizationSleep is critically important for health: If disrupted, it can literally make people sick, upping the risks for ills such as cardiovascular disease, cancer and depression. A good night’s sleep is a luxury for many, but poor people and members of racial and ethnic minorities are more likely than others to not get enough. Learn how slumber affects the body on a physiological level, and the implications for disease risk. What happens during normal sleep and when sleep is disrupted? What factors contribute to disparities in sleep health and how can they be remedied? And how can we all practice good sleep hygiene? https://cassyni-user-files-prod.s3.amazonaws.com/7sqkCiG4cuJ5NF5aDwRBdp https://cassyni.com/slides/outline/77s5hFhYuGj7BdfFV7smSu https://cassyni.com/events/77s5hFhYuGj7BdfFV7smSu/abstract https://cassyni-user-files-prod.s3.amazonaws.com/SwMUXpA2BchfEDTumF4GWS https://cassyni.com/events/77s5hFhYuGj7BdfFV7smSu?videoPreview=1 Hybrid alternative protein-based foods: designing a healthier and more sustainable food supplynohttps://cassyni.com/events/77s5hFhYuGj7BdfFV7smSu?videoPreview=12025-10-22T14:00:00+00:005422.8Frontiers in Science### Strategies for combining protein sources to develop nutritious, sustainable, and broadly adopted foods Explore the potential for hybrid alternative protein-based foods as healthier, tastier, more sustainable alternatives to animal products. Hear from the authors of a recent [Frontiers in Science article](https://www.frontiersin.org/journals/science/articles/10.3389/fsci.2025.1599300/full) as they examine how these hybrids—made by combining alternative protein sources like plants, fungi, insects, and cell-cultivated meat—can help reduce the negative impacts of traditional animal agriculture on health, the environment, and animal welfare. The researchers emphasize the need for collaboration between science, industry, and regulators to optimize protein combinations that balance nutrition, flavor, sustainability, and affordability. Our expert panel will also discuss key challenges—consumer acceptance, cost, scalability, and regulatory implications—that must be addressed before hybrids can become mainstream, commercially viable meat alternatives. [Click here to register.](events.frontiersin.org/hybrid-alternative-proteins/cassyni)https://cassyni-user-files-prod.s3.amazonaws.com/SwMUXpA2BchfEDTumF4GWS https://cassyni.com/slides/outline/FWdkTD4VjoobhavUw83F3K https://cassyni.com/events/FWdkTD4VjoobhavUw83F3K/abstract https://cassyni-user-files-prod.s3.amazonaws.com/QKCha71fferUVdrpDDwA7G https://cassyni.com/events/FWdkTD4VjoobhavUw83F3K?videoPreview=1 Understanding the interplay of winds and accretion in protoplanetary discsnohttps://cassyni.com/events/FWdkTD4VjoobhavUw83F3K?videoPreview=12026-04-23T08:00:00+00:003207.12The Edinburgh Fluid Dynamics Group (EFDG)Protoplanetary discs are well known examples of accretion discs, a concept initially hypothesised by Laplace in the case of the primordial solar nebula and only shown to apply to observed discs around young stars in the last few decades. Accretion onto the central star requires torques to drive radial gas flows in the disc but the origin of such torques remains unclear. Similarly, there is ample evidence from blue shifted forbidden line emission from above the disc surface that strong winds drive mass loss from discs. Both these flows (wind and accretion) influence when, how and where planets form and involve a wealth of hydrodynamical phenomena. UV/X-ray–driven disc winds, acting in concert with accretion, can produce a rapid disc-clearing phase consistent with observed disc demographics, but their mass-loss rates are still poorly determined observationally. I’ll outline an axisymmetric, Parker-wind–like self-similar framework for the wind geometry and flow, and discuss how new non-equilibrium thermo-chemical hydrodynamics calculations change key diagnostics (e.g. molecular emission), offering the prospect of observationally determining wind mass-loss rates in the coming years.https://cassyni-user-files-prod.s3.amazonaws.com/QKCha71fferUVdrpDDwA7G https://cassyni.com/slides/outline/gjSBjan5Ee2nmR1tCsyTT https://cassyni.com/events/gjSBjan5Ee2nmR1tCsyTT/abstract https://cassyni-user-files-prod.s3.amazonaws.com/GCMxSExZ83LKHx3N2EAhL https://cassyni.com/events/gjSBjan5Ee2nmR1tCsyTT?videoPreview=1 Bubble dynamics in complex fluidsnohttps://cassyni.com/events/gjSBjan5Ee2nmR1tCsyTT?videoPreview=12025-02-07T06:00:00+00:003364.16Leeds Institute for Fluid DynamicsBubble dynamics and cavitation have traditionally been studied in the context of underwater acoustics and, more recently, biomedical applications. I will discuss how the deformation and flow fields generated by acoustically-driven bubbles can be used to drive self-assembly of novel microstructures in complex fluids. Bubble dynamics driven at ultrasonic frequencies probe time scales as short as $10^{–3} − 10^{–6}$s, comparable to the smallest relaxation time scales for complex fluids containing suspended particles or macromolecules. I will describe how, in this dynamical regime, dynamic capillary interactions arise between colloidal particles adsorbed at a fluid interface, producing particle networks that dominate the mechanics of these complex interfaces under flow. I will also describe a new flow-induced mechanism caused by bubble dynamics, that produces ordered microstructures in colloidal gels. This mechanism can enable energy-efficient processing methods of colloidal-gel materials, including inks, battery electrodes, construction materials. I will also discuss the emerging approach of using bubble dynamics to probe the high-frequency viscoelastic properties of complex fluids and soft materials, which has brought together the communities of cavitation and rheology to address new challenges in characterization of soft materials.https://cassyni-user-files-prod.s3.amazonaws.com/GCMxSExZ83LKHx3N2EAhL https://cassyni.com/slides/outline/E2wYLpku3gUtgSeprZShbb https://cassyni.com/events/E2wYLpku3gUtgSeprZShbb/abstract https://cassyni-user-files-prod.s3.amazonaws.com/FKMfDFweyrtRDPBjUAMCTY https://cassyni.com/events/E2wYLpku3gUtgSeprZShbb?videoPreview=1 The life and death of turbulencenohttps://cassyni.com/events/E2wYLpku3gUtgSeprZShbb?videoPreview=12020-10-05T06:00:00+00:003800.08Leeds Institute for Fluid DynamicsTurbulence is the last great unsolved problem of classical physics. But there is no consensus on what it would mean to actually solve this problem. In this talk, I propose that turbulence is most fruitfully regarded as a problem in non-equilibrium statistical mechanics, and will show that this perspective explains turbulent drag behavior measured over 80 years, and makes predictions that have been experimentally tested in 2D turbulent soap films. I will also explain how this perspective is useful in understanding the laminar-turbulence transition, establishing it as a non-equilibrium phase transition whose critical behavior has been predicted and tested experimentally. This work connects transitional turbulence with statistical mechanics and renormalization group theory, high energy hadron scattering, the statistics of extreme events, and even population biology.https://cassyni-user-files-prod.s3.amazonaws.com/FKMfDFweyrtRDPBjUAMCTY https://cassyni.com/slides/outline/96TVszHef6wsHLwUr5jhsT https://cassyni.com/events/96TVszHef6wsHLwUr5jhsT/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Nne5xzXGnt8rZ3cbkwGUKg https://cassyni.com/events/96TVszHef6wsHLwUr5jhsT?videoPreview=1 Non-destructive bridge damage characterisation: from traditional approaches to novel ensemble learning nohttps://cassyni.com/events/96TVszHef6wsHLwUr5jhsT?videoPreview=12025-09-17T07:00:00+00:002887.52ArtIStE - Artificial Intelligence in Structural EngineeringThis presentation explores the evolution of bridge condition assessment from traditional engineering methods to state-of-the-art digital and data-driven approaches. It begins by revisiting conventional techniques, including visual inspections, forensic investigations, and finite element back-analysis, as applied in landmark case studies such as the Polyfytos Bridge in Greece. These foundational methods provide the baseline upon which more advanced technologies—such as Synthetic Aperture Radar (SAR) Interferometry, UAV-based photogrammetry, and Digital Twins—are introduced and critically evaluated. The transition from analogue to digital methods is examined in the context of ageing infrastructure, sustainability, resilience, and the need for rapid, scalable, and cost-effective solutions. Through selected European research projects and real-world applications, the talk proposes a multi-scale and multi-sensor methodology that combines traditional engineering judgment with next-generation monitoring and modelling systems. Next, a novel, cause-agnostic, machine learning framework for non-destructive bridge damage state identification is presented, purposefully developed for applications with extremely limited datasets. We demonstrate the evolution of an ensemble-based methodology, from the use of general regression neural networks (GRNN) to an enhanced artificial neural network (ANN)-based cascade model, which integrates a new input-doubling data augmentation technique grounded in response surface linearisation. Applied to a real-world balanced cantilever bridge, our method successfully predicted tendon losses in three interdependent deck zones using only 81 observations. The presentation will discuss the theoretical underpinnings, model architecture, validation results, and potential for deployment across infrastructure portfolios, with a particular emphasis on the method’s applicability to data-scarce environments and digital twin platforms.https://cassyni-user-files-prod.s3.amazonaws.com/Nne5xzXGnt8rZ3cbkwGUKg https://cassyni.com/events/JyTCvHk2qcwvHLdueDSWe1/abstract https://cassyni-user-files-prod.s3.amazonaws.com/7yiSANYL6TNPv6jPGrobMp https://cassyni.com/slides/outline/RtXfZroNz2hhn9dV1f1Snh https://cassyni.com/events/RtXfZroNz2hhn9dV1f1Snh/abstract https://cassyni-user-files-prod.s3.amazonaws.com/ErNzm3eE4mByVCyk1oezrS https://cassyni.com/events/RtXfZroNz2hhn9dV1f1Snh?videoPreview=1 An Independent Publishing Industry: The Case for Checks and Balancesnohttps://cassyni.com/events/RtXfZroNz2hhn9dV1f1Snh?videoPreview=12026-01-13T09:00:00+00:003422.04Academic Publishing in EuropeData from the 2025 Edelman Trust Barometer indicates that 63% of global respondents have trouble determining credibility of information and 25% approve of intentionally spreading disinformation to drive change. Against this backdrop and current geo-political currents, there should be wide agreement within the research and scholarly communications eco-system that it is critically important to protect and strengthen sources of validated knowledge, actively build trust in those sources, and protect self-correcting knowledge systems. Key to this is recognising and continually evolving a system of checks and balances at an operational level and in the marketplace that prevent any single actor from dominating knowledge production. Framing the issue in terms of checks and balances brings attention to the fact that all actors in a system have interests and highlights the value of a diverse marketplace of publishers, including independent publishers, for building systemic legitimacy and ultimately in supporting democracy.https://cassyni-user-files-prod.s3.amazonaws.com/ErNzm3eE4mByVCyk1oezrS https://cassyni.com/events/UMmgoH31BKUC9673ZLv5Wd/seminar/qa https://cassyni.com/slides/outline/UMmgoH31BKUC9673ZLv5Wd https://cassyni.com/events/UMmgoH31BKUC9673ZLv5Wd/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Bz8BKja3wN8SKDqVuvbD8z https://cassyni.com/events/UMmgoH31BKUC9673ZLv5Wd?videoPreview=1 Plastics, Agriculture, and the Environment: Environmental and Economic Perspectives on Soil-Biodegradable Mulch Films for Sustainable Agroecosystemsnohttps://cassyni.com/events/UMmgoH31BKUC9673ZLv5Wd?videoPreview=12025-12-03T17:00:00+00:003061.08Environmental Science and EcotechnologyPlastic mulch films (PMs) have become indispensable in modern agriculture for enhancing crop productivity and regulating soil microclimate. Yet, their production, use, and end-of-life management raise pressing environmental concerns. Soil-biodegradable mulch films (BDMs) have emerged as promising eco-friendly alternatives, but questions about their long-term sustainability and economic feasibility persist. This talk presents a life cycle assessment (LCA)–based exploration of mulch films, comparing the environmental and economic implications of PMs and BDMs, identifying key barriers to the widespread adoption of BDMs, and highlighting strategies for their sustainable integration into agroecosystems. The discussion will examine these complexities within agronomic, environmental, and economic contexts, offering actionable insights for researchers, policymakers, and practitioners. Attendees will gain an integrated perspective on how biodegradable agricultural plastics can drive the transition toward more sustainable and resilient agroecosystems. https://cassyni-user-files-prod.s3.amazonaws.com/Bz8BKja3wN8SKDqVuvbD8z https://cassyni.com/slides/outline/SsrVmrcKGJjabP9tQCRDED https://cassyni.com/events/SsrVmrcKGJjabP9tQCRDED/abstract https://cassyni-user-files-prod.s3.amazonaws.com/9s5fgHbsNnCVfFqzVDV4dk https://cassyni.com/events/SsrVmrcKGJjabP9tQCRDED?videoPreview=1 Control of Tissue Flows and Embryo Geometry in Avian Gastrulationnohttps://cassyni.com/events/SsrVmrcKGJjabP9tQCRDED?videoPreview=12026-01-22T15:00:00+00:004538.28Journal of Biological PhysicsEmbryonic tissues undergo coordinated flows during avian gastrulation to establish the body plan. Here, we elucidate how tens of thousands of cells coordinate their behaviors to sculpt the chick embryo's dynamic geometry (size and shape). These two distinct geometric changes are each associated with dynamic curves across which trajectories separate (kinematic repellers). Through physical modeling and experimental manipulations, we selectively eliminate either or both repellers in model and experiments, revealing their mechanistic origins. We find that embryo size is affected by the competition between extraembryonic epiboly and embryonic myosin-driven contraction---which persists when mesoderm induction is blocked. Instead, the characteristic shape change from circular to pear-shaped arises from myosin-driven cell intercalations in the mesendoderm, irrespective of epiboly. These findings elucidate modular mechanisms for the independent control of embryo size and shape during development.https://cassyni-user-files-prod.s3.amazonaws.com/9s5fgHbsNnCVfFqzVDV4dk https://cassyni.com/slides/outline/B4iShAh7ac3YDGBGVabBFB https://cassyni.com/events/B4iShAh7ac3YDGBGVabBFB/abstract https://cassyni-user-files-prod.s3.amazonaws.com/uky4zuaWk1KPEySLLmyjC https://cassyni.com/events/B4iShAh7ac3YDGBGVabBFB?videoPreview=1 Session 4B: Redox Thermochemicalnohttps://cassyni.com/events/B4iShAh7ac3YDGBGVabBFB?videoPreview=12025-10-22T07:30:00+00:006641.56Centre for Energy TechnologyThis seminar session on redox thermochemical processes explored advanced pathways for sustainable hydrogen and fuel production, emphasizing the integration of solar thermal energy and electrochemical methods to address decarbonization challenges in transportation and industry. Synhelion’s industrial-scale solar-driven reforming process was presented, demonstrating continuous operation of a mixed reforming reactor that converts biomass-derived biogas into synthesis gas and subsequently into drop-in liquid hydrocarbons. This approach leverages solar heat and thermal energy storage to enhance carbon efficiency and scalability, targeting the growing demand for sustainable aviation fuels (SAF) and addressing supply gaps projected beyond 2030. Complementing this, the German Aerospace Center’s work on sulfur-based thermochemical cycles was detailed, focusing on the hybrid sulfur cycle for efficient hydrogen production via sulfuric acid decomposition coupled with SO2-depolarized electrolysis, and the solid sulfur cycle for long-duration energy storage. These processes benefit from established sulfuric acid industrial infrastructure and show promise for integration into existing chemical plants, with ongoing catalyst development and pilot-scale demonstrations. Additionally, novel research on lowering thermochemical water-splitting temperatures through AI-driven materials discovery and thermo-electrochemical cycles was discussed. Machine learning models were employed to predict oxygen vacancy formation enthalpies in perovskite oxides, accelerating the identification of promising redox materials. The application of electrical potentials in thermal reduction steps demonstrated a reduction in operating temperatures, offering pathways to improve kinetics and energy efficiency. Panel discussions highlighted the importance of hybridizing thermal and electrical inputs, leveraging existing industrial assets for technology de-risking, and the critical role of regulatory frameworks and cross-sector collaboration to accelerate commercialization. The session underscored the complementary nature of these approaches in advancing scalable, low-carbon fuel and hydrogen production technologies.https://cassyni-user-files-prod.s3.amazonaws.com/uky4zuaWk1KPEySLLmyjC https://cassyni.com/events/TrncP3CquXoNi4sGf9rvAR/abstract https://cassyni-user-files-prod.s3.amazonaws.com/FohXcptuctB9JhgBjULUkn https://cassyni.com/slides/outline/E2dh5u69ciHu4tQZkUWWRb https://cassyni.com/events/E2dh5u69ciHu4tQZkUWWRb/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Qdn6XZPhwRxvQbMWMgaUir https://cassyni.com/events/E2dh5u69ciHu4tQZkUWWRb?videoPreview=1 Nano TransMed Youth Forum 2025, Session Vnohttps://cassyni.com/events/E2dh5u69ciHu4tQZkUWWRb?videoPreview=12025-11-07T01:00:00+00:003135.92None[Nano TransMed (NTM)] (https://www.keaipublishing.com/en/journals/nano-transmed/) is an open access peer-reviewed journal. To promote cross-boundary research and linkage between nanotechnology and clinical applications, as well as to build an inclusive, barrier-free communication platform for emerging talent in the community, NTM brings together young scholars across the field to share real-time cutting-edge technologies and the latest research findings. 2025 Session V was held on Nov.07, 2025.https://cassyni-user-files-prod.s3.amazonaws.com/Qdn6XZPhwRxvQbMWMgaUir https://cassyni.com/slides/outline/969ed4cuE8ksfnhDjzoWhT https://cassyni.com/events/969ed4cuE8ksfnhDjzoWhT/abstract https://cassyni-user-files-prod.s3.amazonaws.com/CJe2QSKiPfb79wknX7oMfc https://cassyni.com/events/969ed4cuE8ksfnhDjzoWhT?videoPreview=1 Q&A Sessionnohttps://cassyni.com/events/969ed4cuE8ksfnhDjzoWhT?videoPreview=12026-02-25T15:00:00+00:001690.08Researcher to ReaderThis discussion addressed the pervasive issue of bias in artificial intelligence systems, particularly large language models (LLMs) trained predominantly on English language data (reportedly 93%). This linguistic imbalance contributes to the underrepresentation of diverse languages and regions, exacerbated by a lack of funding for relevant training data infrastructure in global south communities. Concerns were also raised about the inherent implicit biases of human operators in "human-in-the-loop" systems, alongside observations of user disengagement with highly functional AI tools over time. Proposed solutions highlighted the critical need for increased funding and collaborative initiatives, such as "AI for Bharat," to support multi-language training datasets. A framework for mitigating bias suggested differentiating between AI tools' functional capabilities (low risk) and their knowledge-based outputs (higher risk). The conversation emphasized community engagement, enhanced AI literacy, and collective advocacy to demand greater transparency from major technology companies regarding their models and data sources. Alternative strategies included fostering competition with more inclusive AI tools and proposing diplomatic engagement between academic organizations and large AI developers, treating them as "near-state" entities to influence policy and practice.https://cassyni-user-files-prod.s3.amazonaws.com/CJe2QSKiPfb79wknX7oMfc https://cassyni.com/slides/outline/BZPfrUrXRRXN2jAnHgi9RP https://cassyni.com/events/BZPfrUrXRRXN2jAnHgi9RP/abstract https://cassyni-user-files-prod.s3.amazonaws.com/5LjahSQnshqaXBQYcAofVG https://cassyni.com/events/BZPfrUrXRRXN2jAnHgi9RP?videoPreview=1 Seekers of Sanctuary and Open Research (Lightning Talk)nohttps://cassyni.com/events/BZPfrUrXRRXN2jAnHgi9RP?videoPreview=12026-02-24T15:35:00+00:00294.76Researcher to ReaderSeekers of sanctuary include academics and professionals, cut off from their networks. This talk will relate how Aberdeen University Library hosted an International Open Access week event to engage with lived experience individuals, academics, and charity workers to understand the need for access to research in this important context.https://cassyni-user-files-prod.s3.amazonaws.com/5LjahSQnshqaXBQYcAofVG https://cassyni.com/events/JUVkcgRkyCCsg1rkwhDXCh/abstract https://cassyni-user-files-prod.s3.amazonaws.com/AqC56y1rniLGn1dnzkZ2XY https://cassyni.com/slides/outline/VLm3difJdGPMCHgnZETD9X https://cassyni.com/events/VLm3difJdGPMCHgnZETD9X/abstract https://cassyni-user-files-prod.s3.amazonaws.com/W3YGGqs5GA9YXQTPBGSKLr https://cassyni.com/events/VLm3difJdGPMCHgnZETD9X?videoPreview=1 H4 – Benchmarking Research Development in the Context of Research Administration: SUNDRI as a Use Casenohttps://cassyni.com/events/VLm3difJdGPMCHgnZETD9X?videoPreview=12026-04-21T12:30:00+00:002643.88Research Analytics SummitSupport Networks at Diversified Research Institutions (SUNDRI) is the first nationally representative survey about research development in the context of research administration (RD/RA) at colleges and universities, covering roughly 1,300 doctoral, masters, and baccalaureate institutions. We obtained survey responses from about 350 institutions and merged with NSF data on R&D spending (HERD) and ED data on many other aspects of these institutions (IPEDS). SUNDRI employs key strategies of instrument design such as cognitive testing and modularization; is nationally representative of R1, R2, and other Emerging Research Institutions (using stratified, nonresponse – modeled weights); and enables detailed statistical inference and hypothesis testing. Early – stage findings from this NSF GRANTED – funded study across different Carnegie classifications cover the structure and activities of offices involved in RD/RA, including organizational placement, staffing levels, personnel titles and experience, turnover, work balancing, perceived primary strengths and challenges, measures of applications submitted and awards processed, participation in national organizations, and other characteristics. We will demo an interactive Tableau dashboard of survey results and public data, with a focus on how this dashboard may be used for institutional benchmarking, and we will review design alternatives and challenges. For more details on SUNDRI, please visit the project website at https://sundri.rti.orghttps://cassyni-user-files-prod.s3.amazonaws.com/W3YGGqs5GA9YXQTPBGSKLr https://cassyni.com/slides/outline/58zSNDxb7qFT2bvwdT9ujB https://cassyni.com/events/58zSNDxb7qFT2bvwdT9ujB/abstract https://cassyni-user-files-prod.s3.amazonaws.com/HaxC4DCtTT71JYpC7bFW22 https://cassyni.com/events/58zSNDxb7qFT2bvwdT9ujB?videoPreview=1 Listening to Improve: How Equity and Power Shape Collaboration and Researchnohttps://cassyni.com/events/58zSNDxb7qFT2bvwdT9ujB?videoPreview=12026-05-28T20:00:00+00:003347.04Family MedicineAt the conclusion of this session, attendees will be able to: - Recognize how equity and power shape collaboration. - Understand how attention to equity and power can improve research practices and reduce harm for participants and partners. - Appreciate the role of mentorship and collaboration in equity-focused research.https://cassyni-user-files-prod.s3.amazonaws.com/HaxC4DCtTT71JYpC7bFW22 https://cassyni.com/slides/outline/QQJdHWhwe3mmtM6WLiLHNM https://cassyni.com/events/QQJdHWhwe3mmtM6WLiLHNM/abstract https://cassyni-user-files-prod.s3.amazonaws.com/7CqXdU1ftt9sYnYrn3sqca https://cassyni.com/events/QQJdHWhwe3mmtM6WLiLHNM?videoPreview=1 Introduction to npj Flexible Electronics nohttps://cassyni.com/events/QQJdHWhwe3mmtM6WLiLHNM?videoPreview=12026-04-07T13:00:00+00:001134.6npj Flexible ElectronicsJoin us for a discussion on the progress of *Flexible Electronics*.https://cassyni-user-files-prod.s3.amazonaws.com/7CqXdU1ftt9sYnYrn3sqca https://cassyni.com/slides/outline/Xp2gymQpDv5cNvcyJbC1nM https://cassyni.com/events/Xp2gymQpDv5cNvcyJbC1nM/abstract https://cassyni-user-files-prod.s3.amazonaws.com/2LJMKx8EQPgitc9WzVa2HL https://cassyni.com/events/Xp2gymQpDv5cNvcyJbC1nM?videoPreview=1 Episode 9: A Conversation with Vera Thiel and Andres Trumppnohttps://cassyni.com/events/Xp2gymQpDv5cNvcyJbC1nM?videoPreview=12026-01-08T09:00:00+00:002246.28Advanced ScienceThe heterogeneity of the tumor microenvironment, particularly in pancreatic ductal adenocarcinoma (PDAC), highlights the understudied role of neurons, whose cell bodies are often located in ganglia external to the tumor mass. To enable their study, Trace-and-Seq was developed. This technique retrogradely traces axon structures from the tumor back to corresponding ganglia, allowing for harvesting, dissociation, and sequencing of neuronal cell bodies to analyze their transcriptomic and proteomic profiles. Studies reveal that tumor-innervating neurons are highly dynamic, forming synapses with cancer cells, fibroblasts, immune cells, and endothelial cells. Trace-and-Seq demonstrates extensive transcriptional reprogramming in these neurons, characterized by identity and state switches that increase axonal sprouting and contact with tumor microenvironment components. This reprogramming is not merely acute; neurons partially maintain a "cancer-nerve state" after primary tumor resection in mouse models, contributing to faster tumor outgrowth and potential relapse. Denervating pancreatic tumors, for example by blocking the celiac ganglion, reprograms cancer-associated fibroblasts (CAFs) from tumor-suppressive to pro-inflammatory. This leads to immune cell influx, transforming "cold" tumors into "warm" ones, making them amenable to checkpoint inhibition. Different cancer entities, such as colorectal cancer, exhibit distinct immune modulator deregulation in neurons, suggesting context-dependent reprogramming. These findings emphasize neuronal plasticity in cancer progression and relapse. A multi-center clinical trial is planned for 2026 to combine celiac ganglion destruction/blockade with nab-paclitaxel, with or without checkpoint inhibition, for PDAC. The Trace-and-Seq method is broadly applicable for mapping neural landscapes in various diseases beyond cancer. Continued research aims to identify the specific transcription factors driving these reprogramming events and to understand the long-term persistence of neuronal memory post-treatment.https://cassyni-user-files-prod.s3.amazonaws.com/2LJMKx8EQPgitc9WzVa2HL https://cassyni.com/slides/outline/2B8SCkbKtSrdpNctmttvNZ https://cassyni.com/events/2B8SCkbKtSrdpNctmttvNZ/abstract https://cassyni-user-files-prod.s3.amazonaws.com/EvA2MRbrD6mHmksYWbK5dQ https://cassyni.com/events/2B8SCkbKtSrdpNctmttvNZ?videoPreview=1 Economic Development Incentives: Multicultural Consumer Markets and Black Entrepreneurial Successnohttps://cassyni.com/events/2B8SCkbKtSrdpNctmttvNZ?videoPreview=12025-11-19T18:00:00+00:001128.88Center for Black Entrepreneurship, Spelman CollegeThe 2017 Tax Cuts and Jobs Act introduced Opportunity Zones (OZs) to stimulate economic development through tax benefits for investments in low-income communities. This study investigates the impact of the OZ program on job creation, business growth, and Black entrepreneurial success in Houston, Texas, a city characterized by high ethnic, racial, and linguistic diversity. A difference-in-differences (DiD) identification strategy was employed to estimate causal inferences, utilizing a regression model with tract and year fixed effects. Data were drawn from County Business Patterns, Longitudinal Employer-Household Dynamics, and the Black Wealth Data Center, with Black-owned business counts proxied by self-employment data from the American Community Survey Public Use Microdata Sample (ACS PUMS). The analysis revealed no statistically significant impact of OZ designation on the number of jobs created, overall business counts, or the number of Black-owned businesses. Event study graphs indicated pre-existing declines in businesses and Black-owned businesses within designated OZ tracts prior to policy implementation (2017–2018), with the decline in overall businesses showing a non-significant slowdown after designation. These findings suggest that while the Opportunity Zone policy holds promise, its effectiveness in stimulating economic development in minority and low-income communities may require additional guardrails and complementary supports, such as enhanced training and access to capital. Increased transparency and mandated reporting on metrics like jobs created and housing impacts are also identified as critical for effective program evaluation. Future work includes expanding analysis to other U.S. cities and conducting qualitative interviews.https://cassyni-user-files-prod.s3.amazonaws.com/EvA2MRbrD6mHmksYWbK5dQ https://cassyni.com/events/NRjqDQdjHaV7MBCJYy9x3o/seminar/qa https://cassyni.com/slides/outline/NRjqDQdjHaV7MBCJYy9x3o https://cassyni.com/events/NRjqDQdjHaV7MBCJYy9x3o/abstract https://cassyni-user-files-prod.s3.amazonaws.com/UFJDeQVHEsgW7hTz2sijL2 https://cassyni.com/events/NRjqDQdjHaV7MBCJYy9x3o?videoPreview=1 Angle-resolved photoemission spectroscopy study of samarium nitridenohttps://cassyni.com/events/NRjqDQdjHaV7MBCJYy9x3o?videoPreview=12026-06-02T19:05:00+00:003630.56School of Chemical and Physical SciencesThe nature of the electronic ground state of the ferromagnetic rare earth nitrides remains puzzling, with samarium nitride among the most interesting due to predictions of heavy fermion behaviour and the observation of superconductivity deep within the ferromagnetic state. Direct investigation is needed to shed light on the band structure. We demonstrate successful in situ growth of samarium nitride films with quality that enables study by angle-resolved photoemission spectroscopy. We see clear evidence of a band gap in the ferromagnetic ground state, confirming the semiconducting nature of SmN. The Fermi level is pinned above the conduction band minimum by nitrogen vacancies, leading to electron pockets of Sm 5d character which dominate the electrical conductivity. No evidence is seen for occupied Sm 4f states near the Fermi level.https://cassyni-user-files-prod.s3.amazonaws.com/UFJDeQVHEsgW7hTz2sijL2 https://cassyni.com/slides/outline/TNDsgF6ygA2QobUz44DKTb https://cassyni.com/events/TNDsgF6ygA2QobUz44DKTb/abstract https://cassyni-user-files-prod.s3.amazonaws.com/PmeHhN1YAszkUs64TzWZGa https://cassyni.com/events/TNDsgF6ygA2QobUz44DKTb?videoPreview=1 AEHS Forum Series 20th • Exercise ameliorates metabolic dysfunction-associated steatohepatitis (MASH) through regulating hepatic Sirt2-PARP1-HMGB1 signaling axisnohttps://cassyni.com/events/TNDsgF6ygA2QobUz44DKTb?videoPreview=12026-05-14T01:00:00+00:003415.44NoneTo further boost academic exchanges and build a more dynamic and diversified academic communication platform, [Advanced Exercise and Health Science(AEHS)](https://www.keaipublishing.com/en/journals/advanced-exercise-and-health-science/) has decided to regularly launch the AEHS Online Forum starting from January 2024. AEHS welcomes experts and scholars to share the latest research findings and exchange academic insights on this platform.https://cassyni-user-files-prod.s3.amazonaws.com/PmeHhN1YAszkUs64TzWZGa https://cassyni.com/events/2fofN4kjjGLTe9CFXqdDmw/seminar/qa https://cassyni.com/slides/outline/2fofN4kjjGLTe9CFXqdDmw https://cassyni.com/events/2fofN4kjjGLTe9CFXqdDmw/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Ut9aZh9gzkSJWF6MmrKS22 https://cassyni.com/events/2fofN4kjjGLTe9CFXqdDmw?videoPreview=1 Publishing with Impact: Insights from Wiley Advanced Editors - Part 1nohttps://cassyni.com/events/2fofN4kjjGLTe9CFXqdDmw?videoPreview=12026-06-12T12:00:00+00:004350.2Advanced ScienceThis seminar provided practical insights from Wiley Advanced editors on publishing with impact, aiming to strengthen the author and editor community. Effective manuscript preparation was discussed, emphasizing the crafting of compelling titles and abstracts that balance specificity with broad appeal. A structured approach to scientific writing was advocated, stressing clarity, conciseness, and the use of active voice, while building a coherent narrative through figures and text. The editorial review process was outlined, highlighting critical criteria such as novelty, significance, impact, and scientific rigor, along with the importance of scholarly presentation. Guidance was provided on ethical considerations, avoiding data misrepresentation, and navigating the peer review and rebuttal process, stressing the use of empirical evidence and clear communication. Strategic collaboration with editors was detailed, from pre-submission inquiries and cover letters to managing revisions and proofs. The responsible and transparent use of AI in scientific writing was also addressed, noting its utility for editing and drafting while cautioning against issues like meaning alteration, fabricated references, and overstatement, underscoring the necessity of disclosure. The overarching aim is to empower scientists by facilitating the publication of high-quality, impactful research.https://cassyni-user-files-prod.s3.amazonaws.com/Ut9aZh9gzkSJWF6MmrKS22 https://cassyni.com/events/DY4xP6zHPLWwAR2H9Nruim/abstract https://cassyni-user-files-prod.s3.amazonaws.com/AZ2Xd9YeAigeCU72KwyJtE https://cassyni.com/slides/outline/A5Xj4KTcK8eJ8iiiViUxBw https://cassyni.com/events/A5Xj4KTcK8eJ8iiiViUxBw/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Kk4yZFearRx8hLbm8gSCBQ https://cassyni.com/events/A5Xj4KTcK8eJ8iiiViUxBw?videoPreview=1 Science Advocacy in Action: Zoonotic Disease Risks at Traditional Food Marketsnohttps://cassyni.com/events/A5Xj4KTcK8eJ8iiiViUxBw?videoPreview=12026-01-29T06:00:00+00:00315.2Journal of VirologyTraditional food markets are more than a source of food—they are hubs of culture, commerce, and community. But where humans, animals, and the environment intersect, zoonotic pathogens can emerge. By investigating how pathogens circulate in TFMs, Sparaciari’s research highlights the importance of evidence-based interventions and One Health strategies. These insights not only safeguard public health but also preserve the livelihoods and traditions that depend on these markets, showing how targeted science can create real-world impact.https://cassyni-user-files-prod.s3.amazonaws.com/Kk4yZFearRx8hLbm8gSCBQ https://cassyni.com/events/CYmkHjhEWRQnVfCH3QPaus/seminar/qa https://cassyni.com/slides/outline/CYmkHjhEWRQnVfCH3QPaus https://cassyni.com/events/CYmkHjhEWRQnVfCH3QPaus/abstract https://cassyni-user-files-prod.s3.amazonaws.com/c5hY25dogQLdD7WWHsRze https://cassyni.com/events/CYmkHjhEWRQnVfCH3QPaus?videoPreview=1 Advanced Metamaterials Special Webinar: ANDRES DIAZ LANTADA on "Artificial intelligence aided design, manufacturing and discovery of metamaterials"nohttps://cassyni.com/events/CYmkHjhEWRQnVfCH3QPaus?videoPreview=12026-09-09T11:00:00+00:004138.28Springer Nature Physics CommunityThis talk aims to systematically present the current and expected synergies between artificial intelligence (AI) and additive manufacturing (AM) for advancing metamaterials and metamaterials-based devices with a special focus on the AI-enhanced design and AM of bioinspired, smart or multifunctional metamaterials in connection with healthcare. First, the talk presents the development of a conceptual engineering design methodology based on “constructive dialogues with generative AI” for creativity promotion in connection with metamaterials for healthcare. Second, the implementation and use of taxonomies and ontologies for describing the complex geometries of metamaterials is explained, as well as their applicability to taming generative AI tools for supporting metamaterials discovery and the ideation of biomimetic devices and technologies. Third, the development and application of AI tools for predicting & controlling AM and post-processing results, with a clear focus on error minimization when manufacturing metamaterials, is presented. Finally, trends related to the automated generationand (bio)mechanical evaluation of bioinspired geometries and bio-metamaterials for personalized, high performance and smart or multifunctional medical devices are addressed. https://cassyni-user-files-prod.s3.amazonaws.com/c5hY25dogQLdD7WWHsRze https://cassyni.com/events/8bcY2u2vQ7uMrURzvrjywb/seminar/qa https://cassyni.com/slides/outline/8bcY2u2vQ7uMrURzvrjywb https://cassyni.com/events/8bcY2u2vQ7uMrURzvrjywb/abstract https://cassyni-user-files-prod.s3.amazonaws.com/GjzpCfBL2us4pxi8PCKEKx https://cassyni.com/events/8bcY2u2vQ7uMrURzvrjywb?videoPreview=1 Spotlight on New and Upcoming Researchers Initiativenohttps://cassyni.com/events/8bcY2u2vQ7uMrURzvrjywb?videoPreview=12026-08-18T17:00:00+00:001951.44MultiPsych JournalWe are really passionate at MultiPsych about championing the research of new and upcoming researchers. Join Dr Charlie O'Brien, Editor-in-Chief for Psychology at Wiley to hear more about our 'Spotlight on New and Upcoming Researchers Initiative' where we encourage new and early career researchers to share their papers with us with an open call (all topics related to psychology, psychotherapy, neuroscience and psychiatry welcome!). The papers which are successfully published will form a special collection and the winner of the best paper judged by our Editorial Board Members will receive a £500 prize and the opportunity to share their research paper on our seminar series. Join us and hear more about this exciting initiative!https://cassyni-user-files-prod.s3.amazonaws.com/GjzpCfBL2us4pxi8PCKEKx https://cassyni.com/slides/outline/KxXS6cuzVeeM8iR9HrBkxV https://cassyni.com/events/KxXS6cuzVeeM8iR9HrBkxV/abstract https://cassyni-user-files-prod.s3.amazonaws.com/EoAcUwcTMs1wZe1yAvuoTt https://cassyni.com/events/KxXS6cuzVeeM8iR9HrBkxV?videoPreview=1 Example Video Abstractnohttps://cassyni.com/events/KxXS6cuzVeeM8iR9HrBkxV?videoPreview=12026-06-15T08:00:00+00:00115.04A two-center study investigated the efficacy and safety of multi-session or hyperfractionated Gamma Knife radiosurgery for meningiomas of the brain. The study addressed the clinical dilemma of managing larger-volume meningiomas, where alternatives such as standard fractionated radiation or resection followed by radiosurgery may be considered. Thirty-four patients, typically presenting with larger-volume meningiomas, underwent radiosurgery delivered over 3, 4, or 5 sessions. For specific cases, such as perioptic and larger tumors, a 5-session regimen with 4–5 Gy per session was a typical consideration. An average follow-up of approximately 2.5 years was conducted. Analysis of 5-year actuarial data revealed a high tumor control rate of 91% for low-grade meningiomas, alongside an excellent safety profile for this hyperfractionated approach. These findings contribute to the emerging literature on the use of radiosurgery for lower-grade, larger meningiomas situated in critical locations, particularly in the absence of large-scale randomized trials.https://cassyni-user-files-prod.s3.amazonaws.com/EoAcUwcTMs1wZe1yAvuoTt https://cassyni.com/slides/outline/WL984yW1iGGmfDiHJx8ee1 https://cassyni.com/events/WL984yW1iGGmfDiHJx8ee1/abstract https://cassyni-user-files-prod.s3.amazonaws.com/dnn2GKm4oM1uTSRhQXrK8 https://cassyni.com/events/WL984yW1iGGmfDiHJx8ee1?videoPreview=1 Rethinking thermal vulnerability: from population trade-offs to community contextnohttps://cassyni.com/events/WL984yW1iGGmfDiHJx8ee1?videoPreview=12026-06-02T14:50:00+00:00629.2Why do some plant populations thrive under heat while others collapse, even under similar climates? And why do some communities show large differences in thermal strategies among co-occurring species? In this talk, I synthesize insights from recent works across tropical montane systems to argue that thermal vulnerability is not simply a function of exposure to temperature, but an emergent property shaped by evolutionary history, dispersal constraints, and the biotic environment in which populations and species are embedded. At the population level, coordinated trait syndromes reveal consistent trade-offs between tolerance and avoidance. Yet when scaling up to whole communities, elevation alone fails to explain patterns of divergence. Instead, community diversity and phylogenetic structure appear to play a central role in determining where and how thermal strategies diversify. This perspective challenges the common assumption that climate is the dominant axis structuring thermal niches, and suggests that predictions of climate sensitivity may be incomplete if they ignore who co-occurs with whom, and under which evolutionary constraints. By bridging physiology, evolution, and community ecology, this talk proposes a broader framework for understanding how tropical plant assemblages may respond to increasing thermal extremes.https://cassyni-user-files-prod.s3.amazonaws.com/dnn2GKm4oM1uTSRhQXrK8 https://cassyni.com/slides/outline/BtULeL3pFbr6SF6Nh8MVX https://cassyni.com/events/BtULeL3pFbr6SF6Nh8MVX/abstract https://cassyni-user-files-prod.s3.amazonaws.com/9J6Bxd18gNodYJdUdRH9re https://cassyni.com/events/BtULeL3pFbr6SF6Nh8MVX?videoPreview=1 Electron flat-top distributions and their relation to electron energization in magnetic reconnectionnohttps://cassyni.com/events/BtULeL3pFbr6SF6Nh8MVX?videoPreview=12026-08-20T15:00:00+00:002639.88Journal of Plasma PhysicsMagnetic reconnection is a source of energetic particles throughout the universe. How this energization takes place has been the subject of studies for decades. In this work, we use particle-in-cell simulations to study how so-called electron flat-top distributions relate to electron heating by reconnection. These distributions are known to be generated during reconnection by large-scale electric fields. Their formation corresponds to significant bulk heating, and they are therefore believed to play an important role in seeding subsequent Fermi-acceleration processes. Our results show that flat-tops develop in both the reconnection inflow and outflow, with the outflow populations being isotropized by magnetic curvature scattering. By decomposing the electric field into potential and solenoidal parts, we show that the potential part, despite performing zero net work in the x-line frame, reduces the efficiency of subsequent Fermi acceleration by locally depressing electron energy within the outflow jet. https://cassyni-user-files-prod.s3.amazonaws.com/9J6Bxd18gNodYJdUdRH9re https://cassyni.com/slides/outline/JyHUEWeiRTPZQUTVvoorrH https://cassyni.com/events/JyHUEWeiRTPZQUTVvoorrH/abstract https://cassyni-user-files-prod.s3.amazonaws.com/DTPZn9NEV3sjRgDMGNHg5C https://cassyni.com/events/B4rZGKGYbQgAwxF7tFtidT/abstract https://cassyni-user-files-prod.s3.amazonaws.com/RcGcziGWFrU1qB6ozbxjsC https://cassyni.com/events/BZXnRdRxSE9zmREdgN1gof/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Rx3kHym2KpwTUtWT6k5Sjg https://cassyni.com/events/VLuACsEje51yvykdwukkXo/abstract https://cassyni-user-files-prod.s3.amazonaws.com/4h2Ecmp7wMA6APbjVtnMRg https://cassyni.com/events/QQthgjXZ6dE2xNiwLe3ZdP/abstract https://cassyni-user-files-prod.s3.amazonaws.com/7zAJ7HFeCeFv1u77Kb4PYi https://cassyni.com/events/SPV7sU7erTSo461AhbuW3w/abstract https://cassyni-user-files-prod.s3.amazonaws.com/WowiapmZBZ2Wnm2mrSQgg6 https://cassyni.com/events/H1AdzUpgWkvXCLY2nURwBK/abstract https://cassyni-user-files-prod.s3.amazonaws.com/DL7k71KesTV8DoeKkSbeS2 https://cassyni.com/events/FXDprRt7CPFrmcYuw3kXJM/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Af1fU4qpjPzXRVGwEsVWkn https://cassyni.com/events/YJhv95aE4jZSChCL4XvKBj/abstract https://cassyni-user-files-prod.s3.amazonaws.com/S1w2NcPdXbNvVStsegHDka https://cassyni.com/slides/outline/DYNoe2f2pJhvmfghHdBmfb https://cassyni.com/events/DYNoe2f2pJhvmfghHdBmfb/abstract https://cassyni-user-files-prod.s3.amazonaws.com/V93AVQkzsM2Edge1cJCoTU https://cassyni.com/events/DYNoe2f2pJhvmfghHdBmfb?videoPreview=1 Technology and Multidimensional Inequality — AI and the Human Existential Risknohttps://cassyni.com/events/DYNoe2f2pJhvmfghHdBmfb?videoPreview=12024-10-13T12:00:00+00:004230.32Hong Kong Baptist UniversityThis analysis critically examines the prevalent techno-hype surrounding Artificial Intelligence (AI) and its implications for multidimensional inequality, particularly concerning the poor. Drawing on STS scholarship, economic theory, and liberation theology, the study argues that current AI development and deployment primarily serve the interests of the wealthy, exacerbating existing disparities. Key issues include AI's significant environmental footprint and resource consumption, which divert investments from essential aid. Furthermore, AI systems are not value-neutral; they embed biases from their programmers, leading to discriminatory outcomes in areas such as welfare programs, judicial sentencing (e.g., the COMPAS algorithm), and automated loan processing. The anthropomorphizing of AI is identified as a particularly pernicious danger, as the concept of "intelligence" within AI models reflects a narrow, mathematically-driven, and bourgeois educational standard. This fosters a hierarchical moral valuation that devalues the poor and marginalized, who often fall short of these idealized "intelligent" traits. The prioritization of abstract AI "rights" over the tangible human rights of vulnerable populations is highlighted, illustrating a "techno-mirror" reflecting the narcissistic self-image of elites. While acknowledging AI's utility for specific quantitative tasks (e.g., protein folding in drug discovery, medical diagnostics), the analysis concludes that its widespread application within a capitalist framework risks further disenfranchisement and dehumanization of the poor. A fundamental reassessment of moral priorities is advocated, urging a shift to apply AI as a tool for authentic human flourishing, disconnected from notions of machine rights and re-evaluating human dignity beyond AI-centric intelligence metrics.https://cassyni-user-files-prod.s3.amazonaws.com/V93AVQkzsM2Edge1cJCoTU https://cassyni.com/events/HWCxdygcbGSnxjqMxWEdc9/abstract https://cassyni-user-files-prod.s3.amazonaws.com/EpfFfuiexsBtJmXp3tqKe6 https://cassyni.com/slides/outline/3Am7fg51bh5WFAPZGXEsz5 https://cassyni.com/events/3Am7fg51bh5WFAPZGXEsz5/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Tt5GPUueSPBA6JPogwegAJ https://cassyni.com/events/3Am7fg51bh5WFAPZGXEsz5?videoPreview=1 Christian Perspective on Moral Lawnohttps://cassyni.com/events/3Am7fg51bh5WFAPZGXEsz5?videoPreview=12021-09-08T12:00:00+00:00430.2Hong Kong Baptist UniversityWhy does moral law matter? Where does the idea come from? What does it requires of us?https://cassyni-user-files-prod.s3.amazonaws.com/Tt5GPUueSPBA6JPogwegAJ https://cassyni.com/slides/outline/A5qaKF8Mk6qHjyP8dxop8m https://cassyni.com/events/A5qaKF8Mk6qHjyP8dxop8m/abstract https://cassyni-user-files-prod.s3.amazonaws.com/6q5BrBDRapRAyPRR4G6jhG https://cassyni.com/events/A5qaKF8Mk6qHjyP8dxop8m?videoPreview=1 Falconieri - La Suave Melodianohttps://cassyni.com/events/A5qaKF8Mk6qHjyP8dxop8m?videoPreview=12022-11-01T12:00:00+00:00185.92Hong Kong Baptist UniversityNo abstracthttps://cassyni-user-files-prod.s3.amazonaws.com/6q5BrBDRapRAyPRR4G6jhG https://cassyni.com/events/CZ5bYfMywPbn6urhBeiSrh/abstract https://cassyni-user-files-prod.s3.amazonaws.com/2VsdY3q9kSGbD3U4LFYSZ4 https://cassyni.com/events/CZ5bYfMywPbn6urhBeiSrh?videoPreview=1 Prof. Cherian George on PAP's insecurities, SG media decline & life after GE2025nohttps://cassyni.com/events/CZ5bYfMywPbn6urhBeiSrh?videoPreview=12025-05-09T12:00:00+00:004723.88Hong Kong Baptist UniversityCherian George, Professor of Media & Politics, author, and ex-Straits Times political journalist, joins us to unpack the state of Singapore’s media, politics, and public discourse. We also cover GE2025, the problems & future of the PAP and the Opposition, how academic freedom was constrained in Singapore and how it ultimately affected his career. And with all that, Prof Cherian shares why he continutes to write about his home country even from abroad.https://cassyni-user-files-prod.s3.amazonaws.com/2VsdY3q9kSGbD3U4LFYSZ4 https://cassyni.com/slides/outline/LwgXcqdcMm7s4nBJ19MYP7 https://cassyni.com/events/LwgXcqdcMm7s4nBJ19MYP7/abstract https://cassyni-user-files-prod.s3.amazonaws.com/8LveQXnsJUsCiFNeDyraog https://cassyni.com/events/LwgXcqdcMm7s4nBJ19MYP7?videoPreview=1 EP1 - Ei Ei San X Evelynnohttps://cassyni.com/events/LwgXcqdcMm7s4nBJ19MYP7?videoPreview=12023-12-10T12:00:00+00:002119.28Hong Kong Baptist UniversityNo abstracthttps://cassyni-user-files-prod.s3.amazonaws.com/8LveQXnsJUsCiFNeDyraog https://cassyni.com/slides/outline/WL11VpvahTe8vXeRvGq7Fj https://cassyni.com/events/WL11VpvahTe8vXeRvGq7Fj/abstract https://cassyni-user-files-prod.s3.amazonaws.com/DkTomVFvpRewQf3J7mPmYz https://cassyni.com/events/WL11VpvahTe8vXeRvGq7Fj?videoPreview=1 Gandhi's Non-violencenohttps://cassyni.com/events/WL11VpvahTe8vXeRvGq7Fj?videoPreview=12021-08-19T12:00:00+00:00479.44Hong Kong Baptist UniversityHow Gandhi discovered Non-violence as a practical solution to political problems? How can Non-violence be used for social service? How Gandhi applied Non-violence and satyagraha in social activism?https://cassyni-user-files-prod.s3.amazonaws.com/DkTomVFvpRewQf3J7mPmYz https://cassyni.com/slides/outline/RPWy2zTLJt77XRw5uo87Xb https://cassyni.com/events/RPWy2zTLJt77XRw5uo87Xb/abstract https://cassyni-user-files-prod.s3.amazonaws.com/GEo768sK5K44DrXhDuFtsp https://cassyni.com/events/RPWy2zTLJt77XRw5uo87Xb?videoPreview=1 What are Catholic Indulgences?nohttps://cassyni.com/events/RPWy2zTLJt77XRw5uo87Xb?videoPreview=12025-09-18T12:00:00+00:003789.92Hong Kong Baptist UniversityIndulgences are an important part of the Protestant-Catholic disagreement and can radically transform your faith and relation with God. In this video, Fr. James Dominic Rooney joins us to describe what indulgences are, arguments for indulgences, and how Christians can approach them.https://cassyni-user-files-prod.s3.amazonaws.com/GEo768sK5K44DrXhDuFtsp https://cassyni.com/events/68EQELDsC2WEkqtazVXoqP/abstract https://cassyni-user-files-prod.s3.amazonaws.com/2xVrNKftyfzXrT6jmVyCYE https://cassyni.com/events/68EQELDsC2WEkqtazVXoqP?videoPreview=1 Further Studies in Koreanohttps://cassyni.com/events/68EQELDsC2WEkqtazVXoqP?videoPreview=12020-08-20T12:00:00+00:003618.64Hong Kong Baptist UniversityAbstract not yet added.https://cassyni-user-files-prod.s3.amazonaws.com/2xVrNKftyfzXrT6jmVyCYE https://cassyni.com/slides/outline/8bURTkTVPKGj7nN9YBSSZK https://cassyni.com/events/8bURTkTVPKGj7nN9YBSSZK/abstract https://cassyni-user-files-prod.s3.amazonaws.com/iw4suRSkKyRcoJPkZDh6W https://cassyni.com/events/8bURTkTVPKGj7nN9YBSSZK?videoPreview=1 Authoritarian Populism in Singaporenohttps://cassyni.com/events/8bURTkTVPKGj7nN9YBSSZK?videoPreview=12023-10-26T12:00:00+00:001135.84Hong Kong Baptist UniversityNo abstracthttps://cassyni-user-files-prod.s3.amazonaws.com/iw4suRSkKyRcoJPkZDh6W https://cassyni.com/slides/outline/BkMmVkcoSyDMkBEz1pp7F https://cassyni.com/events/BkMmVkcoSyDMkBEz1pp7F/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Tc6ikfxnotkS56r8PYp8Fp https://cassyni.com/events/BkMmVkcoSyDMkBEz1pp7F?videoPreview=1 Choral Voice and Cultural Difference in Practice as Researchnohttps://cassyni.com/events/BkMmVkcoSyDMkBEz1pp7F?videoPreview=12021-04-16T12:00:00+00:001432.16Hong Kong Baptist UniversityProf. John Winzenburg shares how he promotes Chinese choral music in dialogue with an international repertoire through Cantoria Hong Kong, the mixed choir that he established in 2009.https://cassyni-user-files-prod.s3.amazonaws.com/Tc6ikfxnotkS56r8PYp8Fp https://cassyni.com/slides/outline/2g7WczRVAEXTFPrfg5x5im https://cassyni.com/events/2g7WczRVAEXTFPrfg5x5im/abstract https://cassyni-user-files-prod.s3.amazonaws.com/2Ep64FuNr5mp3a5Ep3dkF8 https://cassyni.com/events/2g7WczRVAEXTFPrfg5x5im?videoPreview=1 Passing Daysnohttps://cassyni.com/events/2g7WczRVAEXTFPrfg5x5im?videoPreview=12022-04-28T12:00:00+00:00249.16Hong Kong Baptist UniversityJun Pan reads her poem, 'Passing Days', for the Proverse Spring Reception 2022. Read it in the Proverse Poetry Prize Anthology 2021, "Mingled Voices 6" (Proverse Hong Kong, April 2022), p. 134.https://cassyni-user-files-prod.s3.amazonaws.com/2Ep64FuNr5mp3a5Ep3dkF8 https://cassyni.com/slides/outline/PQvYrFsEZ3tMRierYqGB73 https://cassyni.com/events/PQvYrFsEZ3tMRierYqGB73/abstract https://cassyni-user-files-prod.s3.amazonaws.com/TT5kk4huJdnT48Zf2an3mg https://cassyni.com/events/PQvYrFsEZ3tMRierYqGB73?videoPreview=1 S04 E06 – Translanguaging on the Streets of Hong Kongnohttps://cassyni.com/events/PQvYrFsEZ3tMRierYqGB73?videoPreview=12023-12-01T12:00:00+00:003202.68Hong Kong Baptist UniversityIn this episode of the Conversations Podcast Fatih interviews two academics from Hong Kong. Max Lee from Hong Kong Baptist University and Nick Wong from Hong Kong University of Science and Technology. Together they try to explain to Fatih what Translanguaging really is.https://cassyni-user-files-prod.s3.amazonaws.com/TT5kk4huJdnT48Zf2an3mg https://cassyni.com/slides/outline/KxPKXULZUr1iQ2MHuAtDaD https://cassyni.com/events/KxPKXULZUr1iQ2MHuAtDaD/abstract https://cassyni-user-files-prod.s3.amazonaws.com/JPboMzFhVJs4m22QopAwta https://cassyni.com/events/KxPKXULZUr1iQ2MHuAtDaD?videoPreview=1 Intellectual and Activist Interventions in Contemporary Timesnohttps://cassyni.com/events/KxPKXULZUr1iQ2MHuAtDaD?videoPreview=12024-03-22T12:00:00+00:004919.96Hong Kong Baptist UniversityThe 49th annual Scholar and Feminist Conference will explore transnational Black feminism in the context of “third world” liberatory movements since the 1940s. At the height of struggles for anti-colonial independence in the African subcontinent and diasporic communities during the 1960s and 1970s, the praxis of Black feminist alliances proved to be foundational to global anti-racist and anti-imperial radicalism. We aim to consider how Black feminist solidarity was forged across a broader geopolitical frame that includes the Indian, Atlantic and Pacific Oceans, strengthening local mobilizations and generating new transnational liberatory possibilities. We will also chronicle the evolution of transnational Black feminism since then, and how the shift from anti-colonialism to neoliberalism impacted the radical possibilities embedded in attempts at self-determination and collaboration across geographic divides.https://cassyni-user-files-prod.s3.amazonaws.com/JPboMzFhVJs4m22QopAwta https://cassyni.com/slides/outline/WpecYWa78vCBvJBKWi7uX3 https://cassyni.com/events/WpecYWa78vCBvJBKWi7uX3/abstract https://cassyni-user-files-prod.s3.amazonaws.com/ReWB4qwRzHF81KLQJ4tyCz https://cassyni.com/events/WpecYWa78vCBvJBKWi7uX3?videoPreview=1 Untold Stories of Hong Kong: Episode 11nohttps://cassyni.com/events/WpecYWa78vCBvJBKWi7uX3?videoPreview=12024-06-09T12:00:00+00:001953.64Hong Kong Baptist UniversityThe "Untold Stories of Hong Kong" project uses multimedia narratives to explore the experiences of marginalized communities within the city, aiming to counteract negative media portrayals and address systemic injustices. The initiative involved interdisciplinary researchers conducting interviews with 10 individuals from diverse backgrounds, including refugees, asylum seekers, ethnic minorities (such as South Asians), and persons with disabilities. The study was informed by the researchers' own experiences with displacement, marginalization, and identity formation. The analysis reveals that marginalization is a fluid, contextual, and individualized experience, often normalized through linguistic and systemic violence. Despite these challenges, interviewees demonstrated significant resilience, adaptability, and creativity—expressed through music, literature, and culinary practices—in constructing a sense of "home" and belonging in Hong Kong. This "shape-shifting" highlights agency and resourcefulness in navigating complex social landscapes. The project emphasizes the importance of making these diverse stories visible and impactful for future generations. Future directions include organizing a conference to expand scholarly dialogue globally and developing educational initiatives, with the overarching goal of fostering a more inclusive society where the concept of a "marginalized population" diminishes, recognizing these stories as integral to Hong Kong's identity.https://cassyni-user-files-prod.s3.amazonaws.com/ReWB4qwRzHF81KLQJ4tyCz https://cassyni.com/slides/outline/3ezNzuzEzjjhigeoXhjSqB https://cassyni.com/events/3ezNzuzEzjjhigeoXhjSqB/abstract https://cassyni-user-files-prod.s3.amazonaws.com/XhSptDccN92NAdxkT1G9fC https://cassyni.com/events/3ezNzuzEzjjhigeoXhjSqB?videoPreview=1 Researching Digitalisation of the Chinese State Medianohttps://cassyni.com/events/3ezNzuzEzjjhigeoXhjSqB?videoPreview=12023-06-23T12:00:00+00:002561.32Hong Kong Baptist UniversityThis study investigates the production of "soft propaganda" and "edutainment campaigns" by Chinese state-run media, focusing on how digitization reshapes existing media practices and values. The research was motivated by the proliferation of animated explainer videos and social media content (Weibo, WeChat) from state outlets, observed around 2016, which integrated popular cultural elements like hip hop and animation to promote government policies. Adopting an organizational and media sociology perspective, the project employed semi-structured, in-depth interviews with individuals working in three major state-run media outlets. Due to the unique research environment, a snowball recruitment strategy was utilized to establish trust and access. Data analysis followed a grounded theory approach, involving constant comparison, open, axial, and selective coding to identify four prominent, recurrent themes related to media routines, values, and practices. Theoretically, the study extends Bourdieu's field theory by foregrounding the significant role of the political field alongside journalistic and economic forces in shaping Chinese media production. It also introduces the concept of "refraction," demonstrating how media organizations actively appropriate external influences to advance their agendas. Future research directions include examining multi-platform strategies (e.g., Douyin, Bilibili) and evolving content styles. Distinctive features of Chinese soft propaganda include a centralized system yielding homogenizing narratives and a strong emphasis on "emotional governance" and moral correctness.https://cassyni-user-files-prod.s3.amazonaws.com/XhSptDccN92NAdxkT1G9fC https://cassyni.com/events/6e2Xxpzj9H38TqQuv2575o/seminar/qa https://cassyni.com/slides/outline/6e2Xxpzj9H38TqQuv2575o https://cassyni.com/events/6e2Xxpzj9H38TqQuv2575o/abstract https://cassyni-user-files-prod.s3.amazonaws.com/9PPWhDBs4SxQAz1ckbmUF8 https://cassyni.com/events/6e2Xxpzj9H38TqQuv2575o?videoPreview=1 Hyperbolising Diffusion in Flux Reconstruction and the Effect on Performancenohttps://cassyni.com/events/6e2Xxpzj9H38TqQuv2575o?videoPreview=12021-06-03T14:00:00+00:003472.24PyFRThe hyperbolic diffusion (HD) is a method for changing an equation set, such as the Navier--Stokes equations, to be hyperbolic in form. This can have the profound impact of making the minimum time step scale with 1/h --- rather than 1/h^2 --- but at the cost of increasing the number of field variables. Additionally, the approach can offer some unique opportunities for convergence acceleration and optimisation. In this talk, I will give a general introduction to the topic and discuss the state of the ongoing research in this area. After making a case for the HD method, I will go on to explore the opportunities for kernel fusion. The hyperbolised 3D artificial compressibility method for Navier-Stokes leads to a system of 13 equations; this poses some unique challenges in GPU computing. To overcome these challenges, some creative approaches have been used in conjunction with GiMMiK to automatically produce more optimal fused kernels.https://cassyni-user-files-prod.s3.amazonaws.com/9PPWhDBs4SxQAz1ckbmUF8 https://cassyni.com/slides/outline/KyeLfoXSc5hR2EwxRGc62h https://cassyni.com/events/KyeLfoXSc5hR2EwxRGc62h/abstract https://cassyni-user-files-prod.s3.amazonaws.com/HzzzHTnQR4hVXxvaUdEXoL https://cassyni.com/events/KyeLfoXSc5hR2EwxRGc62h?videoPreview=1 Acoustic Metamaterials with Broadband Tunable Impedance Matchingnohttps://cassyni.com/events/KyeLfoXSc5hR2EwxRGc62h?videoPreview=12021-05-25T14:00:00+00:006044.68MetaMATRecent development of acoustic metamaterials opens a door to an unprecedented large design space for acoustic properties such as negative bulk modulus, negative density, and refractive index. Such novel concept paves the way for the design of a new class of acoustic materials and devices with great promise for diverse applications, such as broadband noise insulation, sub-wavelength imaging and acoustic cloak from sonar detection. In this talk, I will present our research progress on advanced design and micro/nanofabrication techniques, to enable exploration and rapid prototyping of architectured metastructures for acoustic waves. These structures show promise on focusing and rerouting ultrasound through broadband metamaterials. As an example, we report a class of impedance transformers to overcome the fundamental limit of narrowband transmission. We experimentally show that the transformer device offers efficient implementation in broadband underwater ultrasound detection with the benefit of being soft and tunable. The broadband impedance matched nonreflecting acoustic metamaterial can also robustly prohibit reflection and reverberation of airborne sound waves over a wide range of incident angles. I will also discuss the acoustic labyrinthine metamaterials which can exhibit extreme constitutive parameters and an exceptional ability to control the phase of sound at deep-subwavelength scale.https://cassyni-user-files-prod.s3.amazonaws.com/HzzzHTnQR4hVXxvaUdEXoL https://cassyni.com/slides/outline/WMG2eA7TphKqYkF6SNYyiD https://cassyni.com/events/WMG2eA7TphKqYkF6SNYyiD/abstract https://cassyni-user-files-prod.s3.amazonaws.com/L6kojNHPHG3ueARoeAFmca https://cassyni.com/events/WMG2eA7TphKqYkF6SNYyiD?videoPreview=1 New results on the range of responses that two-phase composites can have to time varying fieldsnohttps://cassyni.com/events/WMG2eA7TphKqYkF6SNYyiD?videoPreview=12021-01-05T14:00:00+00:004468.6MetaMATIt is now slightly more than 40 years since David Bergman and myself obtained bounds on the effective complex dielectric constant of isotropic composites of two isotropic phases mixed in given proportions. This constant governs the quasistatic response to electromagnetic waves of fixed frequency. Hence it also controls the absorption and refraction of radiation by these composites. There has been renewed interest in these old bounds, in part because they also give shape independent bounds in quasistatics on the amount of energy dielectric or metallic particles of given volume can absorb. Our bounds on the effective complex dielectric constant consisted of a lens shaped region in the complex plane bounded by circular arcs. We show that one bound can be tightened and that the corresponding circular arc corresponds to an assemblage of doubly coated spheres. New hierarchical laminate geometries that attain additional points on the remaining arc are described. Consequently, we see that this bound is very tight, almost optimal. We also bound the quasistatic response to applied electromagnetic fields, or antiplane elastic fields, that can have any variation in time, not necessarily a fixed frequency one. Curiously, judicious choices of the applied field can directly yield the volume fractions of the phases from measurements at specific times. We show how applied fields can be tailored to have this property. The work is joint with my wonderful and energetic collaborators: Christian Kern, Ornella Mattei, Owen Miller, and Mihai Putinar. https://cassyni-user-files-prod.s3.amazonaws.com/L6kojNHPHG3ueARoeAFmca https://cassyni.com/slides/outline/hYVVzXUkhW74jhZuYN7Mf https://cassyni.com/events/hYVVzXUkhW74jhZuYN7Mf/abstract https://cassyni-user-files-prod.s3.amazonaws.com/9ggJbeBxgURxjUXHKcqWaa https://cassyni.com/slides/outline/97QfmPonMNSaJ1HtG6XP9w https://cassyni.com/events/97QfmPonMNSaJ1HtG6XP9w/abstract https://cassyni-user-files-prod.s3.amazonaws.com/PvYcywPKMVEz2JgVu7qXc https://cassyni.com/events/97QfmPonMNSaJ1HtG6XP9w?videoPreview=1 A helping hand: Resources to help you learn and use NZSLnohttps://cassyni.com/events/97QfmPonMNSaJ1HtG6XP9w?videoPreview=12022-05-24T00:40:00+00:00976.2Deaf Studies Research UnitMicky Vale introduces you to our online resources, including a complete beginner’s course programme with videos, an online dictionary, and a platform for sharing and discussing new signs.https://cassyni-user-files-prod.s3.amazonaws.com/PvYcywPKMVEz2JgVu7qXc https://cassyni.com/slides/outline/UNak7XyhrnLGR4PbagQDQq https://cassyni.com/events/UNak7XyhrnLGR4PbagQDQq/abstract https://cassyni-user-files-prod.s3.amazonaws.com/K1hGR5diyHAQd4dkzCxMhQ https://cassyni.com/events/UNak7XyhrnLGR4PbagQDQq?videoPreview=1 UKRmol+: a suite for modelling of electronic processes in molecules interacting with electrons, positrons and photons using the R-matrix methodnohttps://cassyni.com/events/UNak7XyhrnLGR4PbagQDQq?videoPreview=12021-09-21T15:00:00+00:003281.96Computer Physics CommunicationsFifty years ago Phil Burke spearheaded the foundation of Computer Physics Communications. Phil also pioneered the use of R-matrix theory for theoretical studies of electron collisions with atoms and molecules. The R-matrix method involves partitioning the problem into an inner region containing the full physics of the problem and an outer region for which an energy-dependent but greatly simplified scattering problem is solved to give the required observables. The R-matrix method is now the leading computational method for treating electron collisions at low and, increasingly, intermediate energies. I will talk about our recent paper Z. Masin, J. Benda, J.D. Gorfinkiel, A.G. Harvey and J. Tennyson, UKRmol+: a suite for modelling of electronic processes in molecules interacting with electrons, positrons and photons using the R-matrix method, Computer Phys. Comms., 249, 107092 (2020). This paper presents the latest incarnation of the UK molecular R-matrix codes which incorporates a range of new features most notably closer integration with quantum chemistry codes for generating target wavefunctions and other target properties, and the optional use of B-splines as well as or instead of Gaussion Type Orbitals (GTOs) to represent the continuum electron. The use of B-splines can greatly extend the size of the inner region that can be treated successully allowing both larger molecules and more electronically excited states to be treated successfully. Examples of such studies will be given in the talk. To facilitate the use of the UKRmol+ code the QEC (Quantemol Electron Collisions) expert system has been developed which provides users with an easy to use graphical interface for the codes. QEC is now being widely used to tackle a variety of problems, particularly ones involving the provision of electron collision data for studies of technological and other plasmas.https://cassyni-user-files-prod.s3.amazonaws.com/K1hGR5diyHAQd4dkzCxMhQ https://cassyni.com/slides/outline/FXkf2PfwrErfb7TJ4YTa7X https://cassyni.com/events/FXkf2PfwrErfb7TJ4YTa7X/abstract https://cassyni-user-files-prod.s3.amazonaws.com/BY7KXCsBKwWL1BNxEPGV82 https://cassyni.com/events/FXkf2PfwrErfb7TJ4YTa7X?videoPreview=1 Dementia in contact sport athletes: using multiplexed immunofluorescence labelling to study neuropathologynohttps://cassyni.com/events/FXkf2PfwrErfb7TJ4YTa7X?videoPreview=12021-08-03T04:00:00+00:003088.44The Auckland Bioengineering InstituteRepetitive mild traumatic brain injury is linked to a progressive neurodegenerative disorder called chronic traumatic encephalopathy (CTE). CTE has been reported in athletes from a range of sports including rugby, soccer, American football, boxing and ice hockey. CTE neuropathology involves the accumulation of tau protein around blood vessels in the cortical sulci, but we know very little about other brain changes that occur and how they differ from other forms of dementia. In this talk, Dr Murray will introduce her recently funded project which will use multiplexed immunofluorescence to label 50 different antibodies on a single human brain tissue section to investigate the microenvironment of a CTE lesion. To identify the anatomical signature of CTE, this labelling will be also be compared to Alzheimer’s disease and normal aging pathology. Dr Murray is currently establishing the multiplex tissue labelling technique at FMHS and the production of this large, high-content image data presents an opportunity to develop innovative analysis tools for anatomical research. Overall, this project will provide the first comprehensive characterisation of CTE pathology and will identify potential targets to detect and prevent CTE pathology during an athlete's life.https://cassyni-user-files-prod.s3.amazonaws.com/BY7KXCsBKwWL1BNxEPGV82 https://cassyni.com/slides/outline/WqudgqkzG9stYWmz2oqmyX https://cassyni.com/events/WqudgqkzG9stYWmz2oqmyX/abstract https://cassyni-user-files-prod.s3.amazonaws.com/FABtveGUgbk5DAY9suunKQ https://cassyni.com/events/WqudgqkzG9stYWmz2oqmyX?videoPreview=1 3D chiral mechanical metamaterialsnohttps://cassyni.com/events/WqudgqkzG9stYWmz2oqmyX?videoPreview=12020-06-23T14:00:00+00:005169.36MetaMATCalling an object or a metamaterial handed or “chiral” requires it to exhibit (i) broken space-inversion symmetry, (ii) no mirror planes, and (iii) no rotation-reflection symmetries. The absence of these symmetries allows for certain effective material behaviour that would otherwise be forbidden by symmetry. Here, we review our recent progress on three-dimensional (3D) chiral mechanical metamaterials in the linear elastic regime. This includes tailored characteristic length scales of push-to-twist conversion behaviour, ultrasound experiments on acoustical activity with transient nanometer-precision displacement-detection, the mapping of this dynamic behaviour (as well as of the static behaviour) onto effective-medium descriptions beyond Cauchy elasticity, and the possibility of isotropic acoustical activity in rationally designed 3D chiral quasi-crystalline mechanical metamaterials.https://cassyni-user-files-prod.s3.amazonaws.com/FABtveGUgbk5DAY9suunKQ https://cassyni.com/slides/outline/78pFafDgbYDpCJ1eu8fSjP https://cassyni.com/events/78pFafDgbYDpCJ1eu8fSjP/abstract https://cassyni-user-files-prod.s3.amazonaws.com/6sjy6wXEp2W85xBgSS7nQv https://cassyni.com/events/78pFafDgbYDpCJ1eu8fSjP?videoPreview=1 Interaction between breaking-induced vortices and nearbed structures: experimental and numerical investigationnohttps://cassyni.com/events/78pFafDgbYDpCJ1eu8fSjP?videoPreview=12022-04-12T10:40:00+00:001384.04Water WavesDuring the breaking process, vorticity is generated near the air-water interface, and surface vortices move downward, typically as an effect of either spilling or plunging breakers in a 2D or 3D fashion. Further, sharp discontinuities in the seabed promote flow separation and generation of nearbed vortices, as in correspondence of submerged sandy bars or man-made defense structures. The interaction between surface (breaking-induced) vortices and nearbed structures is an important link between upper and lower boundaries of the wave body, especially in terms of mass and momentum transfer, sediment stirring, air-water mixing (Nadaoka et al., 1989). Such vortex interaction has been experimentally and numerically studied on a vertical breakwater that forced a backward-type breaker (Wu et al., 2012; Wang et al., 2018), although the authors used a solitary wave impacting an artificial structure, which generated a fairly small vortex interaction. Laboratory tests are currently ongoing at the Università Politecnica delle Marche (Italy) within the FUNBREAK project framework. A 50m-long wave flume hosts a 2D physical model made of contiguous sloping platforms, where regular waves travel and break over a discontinuity. Wave gauges record the surface level along the flume, while optical measurements are obtained using two high-speed cameras and a 10 W green-light laser (Fig.1a). The particle tracking showed relevant interactions between surface and nearbed vortices (Fig.1b). Furthermore, numerical simulations are run using the in-house code Xdolphin3D (Xie et al., 2020). The N-S equations are discretized using the finite volume method in a Cartesian grid and the VOF method is employed to capture the air-water interface together with a Cartesian cut-cell method to deal with the complex topography. The motion of the wavemaker was input directly into the solver to generate different waves using the moving body method. 2D RANS simulations have been run to check the interaction between surface and nearbed vortices after the discontinuity, while detailed 3D LES are being undertaken to elucidate the insight for the complex 3D vortical structures, which is difficult to measure in laboratory experiments (Fig.1c).https://cassyni-user-files-prod.s3.amazonaws.com/6sjy6wXEp2W85xBgSS7nQv https://cassyni.com/events/884DSmUxfjUbvXyJGB3Lqb/abstract https://cassyni-user-files-prod.s3.amazonaws.com/R3y1KxYeurCKS6Y2sfBDzN https://cassyni.com/slides/outline/3BaAyw1iH9waXSFxFhLM7T https://cassyni.com/events/3BaAyw1iH9waXSFxFhLM7T/abstract https://cassyni-user-files-prod.s3.amazonaws.com/59uPxpVU2xVdehhZb2UTo4 https://cassyni.com/events/3BaAyw1iH9waXSFxFhLM7T?videoPreview=1 The narcissism of small differences: Sociolinguistic points of comparison in Aucklandnohttps://cassyni.com/events/3BaAyw1iH9waXSFxFhLM7T?videoPreview=12021-03-12T16:00:00+00:003355.04Linguistics and Applied Language StudiesThis talk presents results from a three year enquiry into linguistic variation and change in Auckland, our largest city, and the prime site of immigration. The study was designed to explore the extent to which recent migration might be having an impact on how Auckland English sounds and is structured. Recordings of speakers in two age groups across three communities are compared: Titirangi; Papatoetoe/Manurewa; and Mount Roskill. I present some results on the pronunciation of NZ English, determiners, and relative clauses to illustrate the commonalities and differences between the communities. Sociolinguists take as given that the “narcissism of small differences” means small linguistic differences may be interpreted as expression of distinct identities. However, our research team also wonders whether a fixation on small differences becomes a narcissistic justification for researchers who engage in variationist studies.https://cassyni-user-files-prod.s3.amazonaws.com/59uPxpVU2xVdehhZb2UTo4 https://cassyni.com/slides/outline/TPLnFRiRnb5Uh81oBUdeXo https://cassyni.com/events/TPLnFRiRnb5Uh81oBUdeXo/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Bjrt6tL31o2pdsNbntHE5L https://cassyni.com/events/TPLnFRiRnb5Uh81oBUdeXo?videoPreview=1 A free boundary perspective on transmission and inverse scattering problemsnohttps://cassyni.com/events/TPLnFRiRnb5Uh81oBUdeXo?videoPreview=12021-11-18T14:00:00+00:003379.96Partial Differential Equations and ApplicationsIn this talk, I will present some free boundary aspects of transmission and inverse scattering problems. I shall focus on questions related to the regularity theory of solutions and the unknown intefaces, that appear in these problems. The talk will be kept at a narrative and heuristic level.https://cassyni-user-files-prod.s3.amazonaws.com/Bjrt6tL31o2pdsNbntHE5L https://cassyni.com/slides/outline/A6eddW54RZhN2FFXd8uHG9 https://cassyni.com/events/A6eddW54RZhN2FFXd8uHG9/abstract https://cassyni-user-files-prod.s3.amazonaws.com/73eQJTNaghQpwJoYZDyVQz https://cassyni.com/events/A6eddW54RZhN2FFXd8uHG9?videoPreview=1 Random Batch Methods for classical and quantum N-body problemsnohttps://cassyni.com/events/A6eddW54RZhN2FFXd8uHG9?videoPreview=12020-10-12T15:00:00+00:003438.08Partial Differential Equations and ApplicationsWe first develop random batch methods for classical interacting particle systems with large number of particles. These methods use small but random batches for particle interactions, thus the computational cost is reduced from $\mathcal{O}(N^2)$ per time step to $\mathcal{O}(N)$, for a system with $N$ particles with binary interactions. For one of the methods, we give a particle number independent error estimate under some special interactions. This method is also extended to quantum Monte - Carlo methods for N - body Schrodinger equation and will be shown to have significant gains in computational speed up over the classical Metropolis - Hastings algorithm and the Langevin dynamics based Euler - Maruyama method for statistical samplings of general distributions for interacting particles. For quantum N - body Schrodinger equation, we also obtain, for pair - wise random interactions, a convergence estimate for the Wigner transform of the single - particle reduced density matrix of the particle system at time t that is uniform in $N > 1$ and independent of the Planck constant $\hbar$.To this goal we need to introduce a new metric specially tailored to handle at the same time the difficulties pertaining to the small $\hbar$ regime (classical limit), and those pertaining to the large $N$ regime (mean - field limit). This talk is based on joint works with Lei Li, Jian - Guo Liu, Francois Golse, Thierry Paul and Xiantao Li.https://cassyni-user-files-prod.s3.amazonaws.com/73eQJTNaghQpwJoYZDyVQz https://cassyni.com/slides/outline/LxwYmApVUzoZgzmxXF5Qqb https://cassyni.com/events/LxwYmApVUzoZgzmxXF5Qqb/abstract https://cassyni-user-files-prod.s3.amazonaws.com/LXgWo82akZxXHJ3TNFpkyC https://cassyni.com/events/LxwYmApVUzoZgzmxXF5Qqb?videoPreview=1 TAX POLICY WITHOUT CONSULTATION: IS NEW ZEALAND ON A ‘SLIPPERY SLOPE’?nohttps://cassyni.com/events/LxwYmApVUzoZgzmxXF5Qqb?videoPreview=12021-10-28T22:00:00+00:004846.2SACLThis paper analyses recent developments in New Zealand’s tax policy development framework.  Specifically, it contributes to the literature in several ways.  First, it adds to the exploration of the tax policy process in New Zealand via the generic tax policy process (GTPP), especially the instances where the GTPP is not being utilised as originally intended.  The paper also seeks to analysis this development in the context of the slippery slope framework (SSF), through extending the model to embrace the power and trust balance as between the government and taxpayers/practitioners in the context of tax policy development.  With the ongoing status of the GTPP in doubt at the time of writing the conclusions drawn remain tentative. [**Paper here**](https://web.tresorit.com/l/pkl67#UGNkH2IiaMxjA_gfh6wW6Q)https://cassyni-user-files-prod.s3.amazonaws.com/LXgWo82akZxXHJ3TNFpkyC https://cassyni.com/slides/outline/hgc596umW8joRmRJDfejw https://cassyni.com/events/hgc596umW8joRmRJDfejw/abstract https://cassyni-user-files-prod.s3.amazonaws.com/PFhQG7s1wwkkRPtV7XAxwY https://cassyni.com/events/hgc596umW8joRmRJDfejw?videoPreview=1 Asymptotic analysis of time-dependent subwavelength resonatorsnohttps://cassyni.com/events/hgc596umW8joRmRJDfejw?videoPreview=12022-06-14T13:00:00+00:004149.76MetaMATWe study wave propagation inside metamaterials consisting of high-contrast subwavelength resonators whose material parameters oscillate periodically in time. The main result is a capacitance matrix characterization of the band structure, which generalizes previous recent work on static subwavelength metamaterials. This characterization provides both theoretical insight and efficient numerical methods to compute the dispersion relationships of time-dependent structures. We exemplify this in several structures exhibiting interesting wave manipulation properties. Specifically, the time-modulation causes a folding of the band structure of the material, which may induce degenerate points. By breaking time-reversal symmetry, we show that these degeneracies may induce exceptional points or open into non-symmetric, unidirectional band gaps.https://cassyni-user-files-prod.s3.amazonaws.com/PFhQG7s1wwkkRPtV7XAxwY https://cassyni.com/slides/outline/RQmzBKeDS7np9eXkRtqyz5 https://cassyni.com/events/RQmzBKeDS7np9eXkRtqyz5/abstract https://cassyni-user-files-prod.s3.amazonaws.com/A8mKZuiR8tJVfv7q5D1c7Q https://cassyni.com/events/RQmzBKeDS7np9eXkRtqyz5?videoPreview=1 Mars Entry, Descent, and Landing guidance under dynamic uncertaintynohttps://cassyni.com/events/RQmzBKeDS7np9eXkRtqyz5?videoPreview=12021-01-20T14:00:00+00:002498.88Department of AeronauticsFuture Mars exploration missions require improvements of one order of magnitude in landed mass and of two orders of magnitude in landing accuracy with respect to current (Mars 2020) capabilities. These stringent requirements pose significant challenges to current Entry, Descent, and Landing (EDL) guidance algorithms. In addition, the behaviour of the dynamical system is highly uncertain due to the partial knowledge of the Martian atmosphere and of its interaction with the entry vehicle. In this talk, I will give an overview of some recent advances in EDL guidance under dynamic uncertainty. First, I will present a novel approach to reconstruct and predict Martian atmospheric density and wind using a Long Short-Term Memory Network (LSTM), a particular class of recurrent neural networks. The LSTM is trained on simulated inertial measurements from a large number of entry trajectories, in which the controls are computed by the Fully Numerical Predictor-corrector Guidance (FNPEG) algorithm. I show that the network is able to reconstruct atmospheric quantities with very high accuracy, and I am currently working on a generalization of the method to improve the accuracy of the controls obtained through the FNPEG algorithm. I also expound on a stochastic guidance method applying corrections to the controls computed during powered descent to minimize the expected value of the error at landing. The method is based on the observation that, in nonlinear systems, the mean of the propagated pdf does not coincide with the propagated mean. Thus, we feed to the baseline guidance algorithm a corrected target designed to minimize the expected value of the navigation pdf at the surface; with the latter propagated through an Unscented Transform. Both approaches are of significant import for improving the accuracy and robustness of state-of-the-art EDL algorithms.https://cassyni-user-files-prod.s3.amazonaws.com/A8mKZuiR8tJVfv7q5D1c7Q https://cassyni.com/slides/outline/B5yTqVszhqjEqUmw1gK3hf https://cassyni.com/events/B5yTqVszhqjEqUmw1gK3hf/abstract https://cassyni-user-files-prod.s3.amazonaws.com/XPmapXftEyQNLZwTD33FYr https://cassyni.com/events/B5yTqVszhqjEqUmw1gK3hf?videoPreview=1 Blurring the boundaries between cereal crops and model plantsnohttps://cassyni.com/events/B5yTqVszhqjEqUmw1gK3hf?videoPreview=12021-12-02T15:00:00+00:001836.04New PhytologistThe cereal crops rice (Oryza sativa), maize (Zea mays ssp. mays) and wheat (Triticum aestivum) provide half of the food eaten by humankind. However, understanding their biology has proved challenging due to their large size, long lifecycle and large genomes. The model plant Arabidopsis thaliana avoids these practical problems and has provided fundamental understanding of plant biology, however not all of this knowledge is directly transferrable to cereals. Recent developments in gene editing, speed breeding and genome assembly techniques mean that the challenges associated with working with the major cereal crops can be overcome. Resources such as mutant collections and genome sequences are now available for these crops, making them attractive experimental systems with which to make discoveries that are directly applicable to increasing crop production.https://cassyni-user-files-prod.s3.amazonaws.com/XPmapXftEyQNLZwTD33FYr https://cassyni.com/events/LUKZq7grSuBEqhwUDNj4Cu/seminar/qa https://cassyni.com/slides/outline/LUKZq7grSuBEqhwUDNj4Cu https://cassyni.com/events/LUKZq7grSuBEqhwUDNj4Cu/abstract https://cassyni-user-files-prod.s3.amazonaws.com/J2YFg4HZWL8jEcd5samPLA https://cassyni.com/events/LUKZq7grSuBEqhwUDNj4Cu?videoPreview=1 Is “memory” a new parameter for the physical state of matter?nohttps://cassyni.com/events/LUKZq7grSuBEqhwUDNj4Cu?videoPreview=12022-05-10T12:00:00+00:005146.08Physics ReportsMost elementary theories describing processes of matter, like Newtonian dynamics and quantum mechanics, are symmetric with respect to time-reversal, but thermodynamics is not and describes processes that come to rest at equilibrium. A long-standing dispute is represented by the question: “How can microscopic equations of motion that are symmetric to time reversal give rise to macroscopic behavior that clearly does not share this symmetry?” The answer is commonly sought in size, with small systems being time-reversible and large systems not. It turns out that this is not correct. Time-reversibility and thermodynamic reversibility are two different issues. Thermodynamic equilibria are well-defined in terms of entropy or free energy and are reached in processes described by the “arrow of time”. But the process of equilibration can be either reversible or irreversible with respect to time, independent of the system size. There is a second criterion, the system’s memory of a previous state, which does not contribute to thermodynamic parameters. Time-reversible processes are deterministic, and if the past is understood, the future can be predicted. What destroys time-reversibility are non-Newtonian processes, mostly of probabilistic nature, like the decay of excited states.https://cassyni-user-files-prod.s3.amazonaws.com/J2YFg4HZWL8jEcd5samPLA https://cassyni.com/slides/outline/6eAeXyaAA5fmCXUmJhNeU5 https://cassyni.com/events/6eAeXyaAA5fmCXUmJhNeU5/abstract https://cassyni-user-files-prod.s3.amazonaws.com/9mGTv9jwFxpRwvC9kjZ7tz https://cassyni.com/events/6eAeXyaAA5fmCXUmJhNeU5?videoPreview=1 Kirchhoff and Trent Type Theoremsnohttps://cassyni.com/events/6eAeXyaAA5fmCXUmJhNeU5?videoPreview=12022-04-12T19:35:00+00:002141.04Discrete & Computational GeometryNo abstracthttps://cassyni-user-files-prod.s3.amazonaws.com/9mGTv9jwFxpRwvC9kjZ7tz https://cassyni.com/slides/outline/GX8jTeWewEk643UnpG91c1 https://cassyni.com/events/GX8jTeWewEk643UnpG91c1/abstract https://cassyni-user-files-prod.s3.amazonaws.com/5A67zx2FF5Q3ZcNzLRBooC https://cassyni.com/events/GX8jTeWewEk643UnpG91c1?videoPreview=1 Graded Structures of Opposition in Fuzzy Natural Logicnohttps://cassyni.com/events/GX8jTeWewEk643UnpG91c1?videoPreview=12021-05-12T10:40:00+00:005881.04Logica UniversalisThe main objective of this paper is devoted to two main parts. First, the paper introduces logical interpretations of classical structures of opposition that are constructed as extensions of the square of opposition. Blanché’s hexagon as well as two cubes of opposition proposed by Morreti and pairs Keynes–Johnson will be introduced. The second part of this paper is dedicated to a graded extension of the Aristotle’s square and Peterson’s square of opposition with intermediate quantifiers. These quantifiers are linguistic expressions such as “most”, “many”, “a few”, and “almost all”, and they correspond to what are often called “fuzzy quantifiers” in the literature. The graded Peterson’s cube of opposition, which describes properties between two graded squares, will be discussed at the end of this paper.https://cassyni-user-files-prod.s3.amazonaws.com/5A67zx2FF5Q3ZcNzLRBooC https://cassyni.com/slides/outline/PvtRGXjQvTyeh6hf4hwBed https://cassyni.com/events/PvtRGXjQvTyeh6hf4hwBed/abstract https://cassyni-user-files-prod.s3.amazonaws.com/EnGV4U4Mo9WUNHiT9pJNmU https://cassyni.com/events/PvtRGXjQvTyeh6hf4hwBed?videoPreview=1 Hybrid low temperature plasma catalysis for converting stable molecules and the thoughts on the catalyst designnohttps://cassyni.com/events/PvtRGXjQvTyeh6hf4hwBed?videoPreview=12022-10-28T08:00:00+00:002550.36ElsevierNon-thermal plasma (NTP), low-temperature plasma or non-equilibrium plasma is a plasma which is not in thermodynamic equilibrium, is a promising, effective, and efficient technique to promote chemical reactions, especially in presence of a catalyst, overcoming thermodynamic and/or kinetic barriers experienced by the conventional thermocatalysis, exemplified by the NTP-catalytic conversions of stable molecules such as CO2 and N2. However, activation of the catalytic systems under NTP conditions is fundamentally different from that under thermal conditions, and hence the catalyst design towards applications in NTP-catalysis needs to be considered with caution, and the common strategies developed for catalyst design in thermocatalysis may not be appropriate. In this presentation, our resent findings from the research of NTP-catalytic systems will be presented with the special focus on the thought of catalyst design for NTP-catalysis.https://cassyni-user-files-prod.s3.amazonaws.com/EnGV4U4Mo9WUNHiT9pJNmU https://cassyni.com/events/Baegzp3QYfD4ewmSonS1ss/seminar/qa https://cassyni.com/slides/outline/Baegzp3QYfD4ewmSonS1ss https://cassyni.com/events/Baegzp3QYfD4ewmSonS1ss/abstract https://cassyni-user-files-prod.s3.amazonaws.com/6E95GrfHcGYxJ27wM9KioY https://cassyni.com/events/Baegzp3QYfD4ewmSonS1ss?videoPreview=1 To C or not to C? Everything you ever wanted to know about Vitamin Cnohttps://cassyni.com/events/Baegzp3QYfD4ewmSonS1ss?videoPreview=12022-07-05T04:00:00+00:003437.16The Auckland Bioengineering InstituteVitamin C is an essential nutrient that humans are unable to synthesise in vivo and so must be obtained through our daily diet. The vitamin C has pleiotropic roles in human health and disease through acting as an enzyme cofactor for a family of metalloenzymes that have numerous biosynthetic and regulatory roles, including epigenetic and gene transcription regulation. Vitamin C has unique pharmacokinetics and a number of factors affect its in vivo concentrations. This presentation will touch upon its roles in diabetes, cancer and infection (including COVID-19), covering both oral and intravenous use, and will debunk much of the controversy surrounding this fascinating vitamin.https://cassyni-user-files-prod.s3.amazonaws.com/6E95GrfHcGYxJ27wM9KioY https://cassyni.com/slides/outline/JVkmm1ce6RtaJETRTnwPfB https://cassyni.com/events/JVkmm1ce6RtaJETRTnwPfB/abstract https://cassyni-user-files-prod.s3.amazonaws.com/4BaE85TjNFos3pUywz1sWv https://cassyni.com/events/JVkmm1ce6RtaJETRTnwPfB?videoPreview=1 Teleport to the Augmented Real Worldnohttps://cassyni.com/events/JVkmm1ce6RtaJETRTnwPfB?videoPreview=12022-07-20T03:00:00+00:002640.92Computer Graphics GroupNew Zealand is well-known for its beautiful nature, which has contributed to it being a prime destination for many movies and commercials. A strong media and technology ecosystem has been built to support this industry. Computer Graphics (CG) and visual effects (VFX) enables seamless blending between computer generated imagery and recorded real footage. Recent advancements of real-time technologies actuate the transition from off-line post-production to real-time. Immersive media technologies transform the end-user experience from observing, to a high sense of presence within the story. Furthermore, high-speed networking changes the media distribution from a pre-recorded medium to live streaming. This talk will explain the recent convergence of immersive, interactive, and intelligent technologies, introduce a concept of augmented telepresence, the frame work and platform that allow user’s illusion to virtually teleport to the captured real-space to interact with the objects in the media and the state-of-the-art technologies that enhance users’ telepresence. The further extension of the platform with the high-speed network will be able to allow remote interaction and immersive collaboration with people in distance. Recent case studies with public end-users will be introduced including a live-streaming concert to online viewers (controlled by a producer in real-time with augmented live VFX), virtual tourisms, and remote education. Potential applications and future extensions is further discussed in the session. https://cassyni-user-files-prod.s3.amazonaws.com/4BaE85TjNFos3pUywz1sWv https://cassyni.com/slides/outline/JzQNohGAXtSdHzzK4EEBvV https://cassyni.com/events/JzQNohGAXtSdHzzK4EEBvV/abstract https://cassyni-user-files-prod.s3.amazonaws.com/GVwFUG4y3qWEPzCC6mbNFG https://cassyni.com/slides/outline/RuUqTGKWgJCQnoytRfo85B https://cassyni.com/events/RuUqTGKWgJCQnoytRfo85B/abstract https://cassyni-user-files-prod.s3.amazonaws.com/67WYkuasg5V2sgjUeDYxia https://cassyni.com/events/RuUqTGKWgJCQnoytRfo85B?videoPreview=1 A Column Generation Based Heuristic for the Split Delivery Vehicle Routing Problem with Time Windowsnohttps://cassyni.com/events/RuUqTGKWgJCQnoytRfo85B?videoPreview=12021-02-11T15:39:31+00:00546.04Operations Research ForumNo abstracthttps://cassyni-user-files-prod.s3.amazonaws.com/67WYkuasg5V2sgjUeDYxia https://cassyni.com/slides/outline/598YwNY28dt5mHzo28TT7T https://cassyni.com/events/598YwNY28dt5mHzo28TT7T/abstract https://cassyni-user-files-prod.s3.amazonaws.com/2WefaLrJKfyGC4v9q1xHnN https://cassyni.com/events/598YwNY28dt5mHzo28TT7T?videoPreview=1 Topology optimization for next-generation thermal energy storage technologies: recent advances and future directionsnohttps://cassyni.com/events/598YwNY28dt5mHzo28TT7T?videoPreview=12026-09-08T06:00:00+00:00606.16NoneThermal energy storage plays a vital role in integrating renewable energy, recovering industrial waste heat and improving energy-system flexibility. However, conventional storage-unit designs often face a fundamental trade-off between heat-transfer rate, storage capacity and pressure loss. Topology optimization offers a powerful computational approach to overcoming this limitation by identifying high-performance material distributions, heat-transfer structures and flow pathways without relying on predefined geometries. This seminar reviews recent progress in applying topology optimization to sensible, latent and thermochemical heat-storage systems. Representative studies demonstrate improvements ranging from approximately 10% to several-fold, including reductions of 30–50% in phase-change time and increases of up to 47% in heat release from closed thermochemical reactors. The seminar will explain the principal optimization formulations, physical mechanisms and design characteristics associated with each storage technology, with particular attention to topology-optimized fins, flow channels, porous structures and heat exchangers. Remaining challenges and future research opportunities will also be discussed, including multi-operating-condition optimization, strongly coupled multiphysics modelling, artificial-intelligence-assisted design acceleration, additive manufacturing, experimental validation and manufacturability-aware reconstruction. These developments are expected to support the transition of topology optimization from numerical design studies towards practical next-generation thermal energy storage technologies. https://cassyni-user-files-prod.s3.amazonaws.com/2WefaLrJKfyGC4v9q1xHnN https://cassyni.com/slides/outline/UNirggZ8saxu9kTSyMhko7 https://cassyni.com/events/UNirggZ8saxu9kTSyMhko7/abstract https://cassyni-user-files-prod.s3.amazonaws.com/F9kgqyo18EvVwovZcsJ3Pt https://cassyni.com/events/UNirggZ8saxu9kTSyMhko7?videoPreview=1 Engineering approaches for modelling urban heat stress under a comfort and health perspectivenohttps://cassyni.com/events/UNirggZ8saxu9kTSyMhko7?videoPreview=12022-10-14T08:00:00+00:004028.48ElsevierToday, more than 50% of the world population lives in cities, with a prospect of increasing to 70% by 2050. These percentages have already been exceeded in Europe, in particular in the Mediterranean Area, where the urban population rate is of about 68%. On the other hand, also the ageing process of the population is increasing at a worrying rate, and this process has a direct impact on health and vulnerability conditions in the urban context. However, only recently it has been understood how the physical environment of cities becomes a determining factor for the well-being of citizens, especially in light of current climate change and consequent increase of health risks. This presentation aims at showing how the complex physical processes involved in determining the so called Urban Heat Stress, i.e. the high temperatures achieved within urban settlements, can be modelled with engineering-based methods. Such approaches could be used to predict which urban areas are more prone to heat stress, to advise the population of likely health risks on certain very hot days and also to plan suitable mitigation interventions. https://cassyni-user-files-prod.s3.amazonaws.com/F9kgqyo18EvVwovZcsJ3Pt https://cassyni.com/slides/outline/Qunum5p4AL7zidHyXhnpds https://cassyni.com/events/Qunum5p4AL7zidHyXhnpds/abstract https://cassyni-user-files-prod.s3.amazonaws.com/QFYzECp98PSSexd8U7GQza https://cassyni.com/events/Qunum5p4AL7zidHyXhnpds?videoPreview=1 Non-invasive Polarimetric diagnostics of biological tissues aided by Artificial Neural Networks IInohttps://cassyni.com/events/Qunum5p4AL7zidHyXhnpds?videoPreview=12022-12-13T20:20:00+00:0011510.96Computer Graphics GroupAs a part of our collaboration with Ecole Polytechnique, France and Texas A&M University, USA we are excited to be able to host an in-person seminar this year, which will also be broadcast online. We cordially invite you to the talks which will feature world-renowned experts in biomedical optical imaging/light transport theory.https://cassyni-user-files-prod.s3.amazonaws.com/QFYzECp98PSSexd8U7GQza https://cassyni.com/events/Pvaa1c4fVVnf5r3EvTcKho/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Vw7tWeVPukYJY9r4M8dYLe https://cassyni.com/events/LyMtUcYnXQhTtADyomA3Ju/abstract https://cassyni-user-files-prod.s3.amazonaws.com/3qsJZoqRfb49GMEFXfTEWA https://cassyni.com/slides/outline/MU37dviCNEBHhdDVbsH1V7 https://cassyni.com/events/MU37dviCNEBHhdDVbsH1V7/abstract https://cassyni-user-files-prod.s3.amazonaws.com/UmRNHDYsWKdaii4rjARgSi https://cassyni.com/events/LUjuYZR9VK592sPVVtoggD/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Y45oFmBhQAWoWCcBdbbGMC https://cassyni.com/slides/outline/GXZ5B6EwyedzFCvp6nDe5K https://cassyni.com/events/GXZ5B6EwyedzFCvp6nDe5K/abstract https://cassyni-user-files-prod.s3.amazonaws.com/JBhtEtprEdsBXLDUJq4pvi https://cassyni.com/events/GXZ5B6EwyedzFCvp6nDe5K?videoPreview=1 Informing vs Persuading in Scholarly Communicationnohttps://cassyni.com/events/GXZ5B6EwyedzFCvp6nDe5K?videoPreview=12023-07-20T03:00:00+00:005959.92UKRN Journalists receive formal training in the distinction between communication intended to inform vs persuade, but academics typically do not. This workshop will explore the distinction between these two forms of communication, why it matters, their place in scholarly communication in particular, and what different schools of academia can contribute to understanding this distinction. In practice, of course, there will be elements of both informing and persuading in any actual piece of communication. But what elements of persuasion can be controversial? Maybe selective use of data, selective summaries of the balance of existing evidence, moving from a finding to a ‘call to action', the elision from association to causation, use of narrative as a persuasive device, and / or minimising uncertainty. Many of these elements are already considered “questionable research practices”. But what underlies them is a desire to persuade, either of the importance of a finding, or of its truth and implications. Can that desire be corrupting? And how do current incentive structures (e.g., a pressure to describe our research as original, rigorous and significant or novel) in academia contribute to the elision between informing and persuading? We will explore the case, normative or practical, for beginning to concern ourselves with this distinction. We will also explore the difference between the two. What constitutes persuasive communication in an academic context and how does it compare to informative communication? Under what conditions, and in what forms, can a particular piece of communication seek to both inform and persuade, without undermining research integrity?https://cassyni-user-files-prod.s3.amazonaws.com/JBhtEtprEdsBXLDUJq4pvi https://cassyni.com/slides/outline/Bb52iFmhb56xr7DU6JWeMB https://cassyni.com/events/Bb52iFmhb56xr7DU6JWeMB/abstract https://cassyni-user-files-prod.s3.amazonaws.com/P1e7LbkEkFiTMWBB8JsEvA https://cassyni.com/events/Bb52iFmhb56xr7DU6JWeMB?videoPreview=1 aGvHDtrackR and cGvHDtrackR: shiny applications for graft versus host disease management and clinical data collectionnohttps://cassyni.com/events/Bb52iFmhb56xr7DU6JWeMB?videoPreview=12025-01-20T12:00:00+00:00846.52Bone Marrow TransplantationGraft-versus-host disease (GvHD) is one of the most common and troublesome complications after allogeneic hematopoietic stem cell transplantation (HSCT). Despite adequate GvHD prophylaxis, 30-50% of the patients still develop acute or chronic GvHD, often requiring multiple lines of therapy. Therefore, it is crucial to closely monitor the onset and the response of GvHD to therapies to identify the best available treatment for each patient. Currently, some applications (desktop or mobile) which allow to score GvHD severity at bedside are available. However, none of the published systems is designed to record ongoing therapies and to upload data in a database, which can support both clinical decision-making process as well as data collection. To this aim, we developed two Shiny apps: aGvHDtrackR for acute GvHD and cGvHDtrackR for chronic GvHD. These applications record GvHD grading alongside with the therapies used for each patient and allow to export the data in a longitudinal patient-specific database. This is of help for clinical management of patients and for future multicentric studies on GvHD. https://cassyni-user-files-prod.s3.amazonaws.com/P1e7LbkEkFiTMWBB8JsEvA https://cassyni.com/slides/outline/SuE1Nhrjzz8BoCxK6jHWz1 https://cassyni.com/events/SuE1Nhrjzz8BoCxK6jHWz1/abstract https://cassyni-user-files-prod.s3.amazonaws.com/EqMyMPu7YGFAfWHS8hXuRG https://cassyni.com/events/SuE1Nhrjzz8BoCxK6jHWz1?videoPreview=1 Micronaut: Sphingomonas desiccabilis for Space Mining and Sustainable Space Developmentnohttps://cassyni.com/events/SuE1Nhrjzz8BoCxK6jHWz1?videoPreview=12025-03-18T10:00:00+00:00463.04Microbiome Virtual International ForumThe roles of biotechnologies in support of human exploration of celestial bodies have evolved from mere theoretical concepts to tangible realities, driven by the development of cutting-edge biotechnologies. Among these advancements, biomining has emerged as a promising alternative for on-site mining and resource extraction (ISRU) (Linne et al., 2017). Widely employed on Earth, this technology, known as biohydrometallurgy, utilizes single microorganisms or microbial consortia to extract resources from ores or mine waste, with minimal or limited human intervention (Habibi et al., 2020). While numerous microbial species on Earth are typically involved in such processes, specifically classified as iron-oxidizers, studies have demonstrated similar abilities in certain species of fungi and organisms not conventionally associated with extraction processes (Chaerun et al., 2017). Notably, Sphingomonas desiccabilis, a heterotrophic Gram-negative bacterium, has shown remarkable potential as a candidate for supporting space exploration (Santomartino et al., 2022). It has actively extracted industrially significant metals from basaltic rocks under both terrestrial conditions and microgravity environments, such as those found on the International Space Station (ISS) (Loudon et al., 2018). Here we present the results obtained from a ground-based biomining experiment using S. desiccabilis to extract precious and critical elements, such as Rare Earth Elements (REEs) and Platinum Group Elements (PGEs), from seven different rocky substrates. Five of these were collected from Canadian mining sites known to contain PGEs, Icelandic basalt previously used on the ISS, and an eucrite, a type of meteorite whose origin is commonly attributed to Vesta, one of the biggest asteroids in the asteroid belt. Our results demonstrate the active extraction of metals of industrial interest from all the used substrates. Specifically we were able to extract Cr, Pd, Pt, U, V, Sc, Ge and other elements that can be used in-situ in space to support human settlement in a sustainable future on other celestial bodies.https://cassyni-user-files-prod.s3.amazonaws.com/EqMyMPu7YGFAfWHS8hXuRG https://cassyni.com/slides/outline/SQaQL2DDZXa8oSRRWHziih https://cassyni.com/events/SQaQL2DDZXa8oSRRWHziih/abstract https://cassyni-user-files-prod.s3.amazonaws.com/LGEyFzLHDjX5oTBRAifyGz https://cassyni.com/events/SQaQL2DDZXa8oSRRWHziih?videoPreview=1 Grid-Free Evaluation of Phonon-Limited Electronic Relaxation Times and Transport Propertiesnohttps://cassyni.com/events/SQaQL2DDZXa8oSRRWHziih?videoPreview=12025-04-13T18:01:31+00:001423.36Computer Physics CommunicationsPresent calculations of electrical transport properties of materials require evaluations of electron-phonon coupling constants on dense predefined grids of electron and phonon momenta and performing the sums over these momenta. In this work, we present the methodology for calculation of carrier relaxation times and electrical transport properties without the use of a predefined grid. The relaxation times are evaluated by integrating out the delta function that ensures energy conservation and performing an average over the angular components of phonon momentum. The charge carrier mobility is then evaluated as a sum over appropriately sampled electronic momenta. We illustrate our methodology by applying to the Fr{\"o}hlich model and to a real semiconducting material ZnTe. We find that rather accurate results can be obtained with a modest number of electron and phonon momenta, on the order of one hundred each, regardless of the carrier effective mass.https://cassyni-user-files-prod.s3.amazonaws.com/LGEyFzLHDjX5oTBRAifyGz https://cassyni.com/slides/outline/NwcqHnxFSuo8p5TmTG1Wgd https://cassyni.com/events/NwcqHnxFSuo8p5TmTG1Wgd/abstract https://cassyni-user-files-prod.s3.amazonaws.com/WGZ8YNx19afnpBNm1qgyAW https://cassyni.com/events/NwcqHnxFSuo8p5TmTG1Wgd?videoPreview=1 River dolphin cochlea has not evolved convergentlynohttps://cassyni.com/events/NwcqHnxFSuo8p5TmTG1Wgd?videoPreview=12025-05-22T03:00:00+00:00674.96Royal Society PublishingConvergence is often invoked to explain some common morphological features in the crania and postcrania of river dolphins (Cetacea, Odontoceti). Rivers are a challenging, complex, and increasingly threatened habitat and echolocation is a critical tool for their survival. Cochlear morphology can be indicative of hearing and echolocation abilities in toothed whales. Previous analyses of river dolphin cochleae have not included all extant riverine taxa, potentially obscuring their patterns of evolution. Based on 3D models obtained from microCT scans and using a more inclusive definition of river dolphins, we tested for convergent evolution in cochlear morphology, including extant and extinct species in a broader evolutionary framework. Results showed that the cochlea of river dolphins is not significantly disparate from marine forms and there is more interspecific morphological variability than expected. Statistical analyses also revealed the lack of convergence in the cochlea and that other ecological variables shaped the intricate evolutionary landscape of this structure. We hypothesize that river dolphins solved the challenges imposed by the environment via their sound production apparatus (e.g. skull shape, melon, etc.) rather than the cochlea.https://cassyni-user-files-prod.s3.amazonaws.com/WGZ8YNx19afnpBNm1qgyAW https://cassyni.com/slides/outline/3BgfST5FtbeV73TiS8UnQm https://cassyni.com/events/3BgfST5FtbeV73TiS8UnQm/abstract https://cassyni-user-files-prod.s3.amazonaws.com/HVTFSyrymR986jgSWzY8LE https://cassyni.com/events/3BgfST5FtbeV73TiS8UnQm?videoPreview=1 Charm and Bottom Hadrons in Hot Hadronic Matternohttps://cassyni.com/events/3BgfST5FtbeV73TiS8UnQm?videoPreview=12025-08-29T10:31:03+00:002531.88Physics ReportsHeavy quarks, and the hadrons containing them, are excellent probes of the QCD medium formed in high-energy heavy-ion collisions, as they provide essential information on the transport properties of the medium and how quarks color-neutralize into hadrons. Large theoretical and phenomenological efforts have been dedicated thus far to assess the diffusion of charm and bottom quarks in the quark–gluon plasma and their subsequent hadronization into heavy-flavor (HF) hadrons. However, the fireball formed in heavy-ion collisions also features an extended hadronic phase, and therefore any quantitative analysis of experimental observables needs to account for the rescattering of charm and bottom hadrons. We review existing approaches for evaluating the interactions of open HF hadrons in a hadronic heat bath and the pertinent results for scattering amplitudes, spectral functions and transport coefficients. We also discuss transport calculations in heavy-ion collisions that incorporate hadronic heavy-flavor diffusion effects and assess its impact on various observables.https://cassyni-user-files-prod.s3.amazonaws.com/HVTFSyrymR986jgSWzY8LE https://cassyni.com/slides/outline/PSJ4T77fHjGxdYTHFN8Urq https://cassyni.com/events/PSJ4T77fHjGxdYTHFN8Urq/abstract https://cassyni-user-files-prod.s3.amazonaws.com/57xLUYFBU3oaRWJwLArPwt https://cassyni.com/events/PSJ4T77fHjGxdYTHFN8Urq?videoPreview=1 Compact Hydraulic Humanoid Robot Design Optimized for Enhanced Joint Power and Heat Dissipationnohttps://cassyni.com/events/PSJ4T77fHjGxdYTHFN8Urq?videoPreview=12025-06-18T03:00:00+00:001014.2Advances in Mechanical EngineeringHumanoid robots feature a small support base and high flexibility; hydraulic humanoid robots provide additional advantages, including high power output and density. They exhibit significant application prospects in the service industry and specialized fields. This paper presents an innovative design methodology for the hydraulic humanoid robot HZ-1. During movement, the knee and hip pitch joints of the robot require significant power, and the effective dissipation of heat in the hydraulic oil is also crucial for maintaining stable operation of the hydraulic system. To address these challenges, a weighted multi-criteria optimization design method is proposed for knee and hip joint linkage mechanisms to enhance their power performance. Additionally, thigh plates and valve blocks in the leg structure with efficient passive heat dissipation capabilities are designed. A hydraulic pelvis is designed to make the robot more compact by integrating hydraulic circuits with mechanical structures. Finally, experiments involving squatting with a 100 kg load and stable walking are conducted.https://cassyni-user-files-prod.s3.amazonaws.com/57xLUYFBU3oaRWJwLArPwt https://cassyni.com/slides/outline/3gMtbmEfjR8JvWTEEEbkay https://cassyni.com/events/3gMtbmEfjR8JvWTEEEbkay/abstract https://cassyni-user-files-prod.s3.amazonaws.com/PV2xgWUfCPQds1ALB4Et8e https://cassyni.com/events/3gMtbmEfjR8JvWTEEEbkay?videoPreview=1 A non-periodic particle mesh Ewald method for radially symmetric kernels in free spacenohttps://cassyni.com/events/3gMtbmEfjR8JvWTEEEbkay?videoPreview=12025-07-29T14:30:06+00:001795.16Computer Physics CommunicationsI will present the non-periodic particle-mesh Ewald (NPME) method for evaluating pair potentials of charges that interact through a radially symmetric kernel $f(r)$ in free space. The calculation starts by splitting $f(r)$ into a short-range part $f_{s}(r)$ and a smooth long-range part $f_{l}(r)$. The smooth contribution is represented with a Fourier extension obtained numerically by discrete-Fourier-transform interpolation; this numerical route removes the usual restrictions on kernel form, kernel splitting, and box shape, so the same machinery applies to the $1/r,r^{\alpha},\exp(ik_{0}r)/r$ kernels in rectangular volumes. A derivative-matched (DM) kernel split is introduced for arbitrary radial kernels. For Coulomb interactions, DM splitting makes the direct sum roughly twice as fast and reduces the required FFT grid by a factor of two to three compared with the conventional Ewald split. An independent grid-storage scheme reduces the remaining grid memory by a further factor of four. Performance tests were run on a 32-core (64-thread) workstation. For Coulomb systems containing $10^{4}$–$10^{7}$ charges, npme computes potentials about three times faster than a vectorized fmm3D implementation; for Helmholtz systems with $3\times10^{5}$–$3\times10^{7}$ surface charges, the speed-up is roughly a factor of ten. (As an upper-size stress test, the code also completed a one-billion-charge water droplet without exhausting memory, though that case is not aimed at production molecular dynamics.) I will further outline a hybrid Method-of-Moments + NPME application that reproduces the radar cross section of a metal sphere with sixty million surface-current unknowns. The final part of the talk shows initial results for applying DM splitting to periodic PME–yielding similar speed-ups and grid savings–and sketches possible next steps, including a GPU implementation and a two-level PME scheme for large parallel jobs. Code, documentation, and examples are on GitHub; I welcome questions and technical discussions after the talk. https://cassyni-user-files-prod.s3.amazonaws.com/PV2xgWUfCPQds1ALB4Et8e https://cassyni.com/slides/outline/B65xJ1wYKHS9R5yhC7TUzy https://cassyni.com/events/B65xJ1wYKHS9R5yhC7TUzy/abstract https://cassyni-user-files-prod.s3.amazonaws.com/DbeWa6venvU83x3L7jBLKp https://cassyni.com/events/B65xJ1wYKHS9R5yhC7TUzy?videoPreview=1 Weather Forecast for Vacuum Fluctuations in QEDnohttps://cassyni.com/events/B65xJ1wYKHS9R5yhC7TUzy?videoPreview=12025-07-28T18:00:00+00:001663.4Annals of PhysicsWe provide closed analytic expressions for the Uehling and Serber contributions of the vacuum fluctuations in QED using Meijer G-functions. Our work extends recently found results by offering a novel formulation for the Uehling and Serber potentials and explores their properties in more detail. The form of these potentials is analyzed, and their relevance for precision measurements in experiments is investigated. For the Uehling potential, we connect the solution with the propagation of photons through atmospheric turbulence.https://cassyni-user-files-prod.s3.amazonaws.com/DbeWa6venvU83x3L7jBLKp https://cassyni.com/slides/outline/77ZESL2oUJY7a5QzP2waGu https://cassyni.com/events/77ZESL2oUJY7a5QzP2waGu/abstract https://cassyni-user-files-prod.s3.amazonaws.com/AS9caWLbaQ8ukdJgPeKMav https://cassyni.com/events/77ZESL2oUJY7a5QzP2waGu?videoPreview=1 Human gut prophage landscape identifies a prophage-mediated fucosylation mechanism alleviating colitisnohttps://cassyni.com/events/77ZESL2oUJY7a5QzP2waGu?videoPreview=12026-02-10T02:00:00+00:00753.88Microbiome Virtual International ForumFunctions of the human gut virome are little understood, particularly for the hyperabundant prophages integrated in prokaryotic genomes. Here we identified 254,273 prophage sequences in 47.7% of 289,232 human gut metagenomic genomes, significantly expanding the known taxonomic and functional diversity of prophages in the human gut microbiome. Analysis of 8503 gut metagenomic samples showed the ratios of lysogens (cells harboring prophages) to non-lysogens varied widely associated with age, health condition, and geography, with the latter linked to industrialization. Notably, the alterations of the prophage-encoded genes exhibited disease-specific patterns. For inflammatory bowel diseases, the prophage-encoded futC gene, encoding α-1,2-fucosyltransferase, was less prevalent in affected patients. This enzyme was experimentally validated to direct 2-fucosyllactose (2'-FL) biosynthesis in vitro. Here we show that 2'-FL could diminish colitis in mice induced by treatment with dextran sodium sulfate. Mechanistically, 2'-FL promoted maintenance of mucosal barrier integrity, leading to intestinal IgA secretion and intraepithelial CD4⁺CD8αα⁺ T cell development mediated by the gut microbiome. Together, our findings thus link lysogeny to human age, geography, and disease, and demonstrate an immunomodulatory mechanism of prophage-encoded genes in alleviating colitis.https://cassyni-user-files-prod.s3.amazonaws.com/AS9caWLbaQ8ukdJgPeKMav https://cassyni.com/events/GVsiKKKmp14PRpt8JAR99X/abstract https://cassyni-user-files-prod.s3.amazonaws.com/TNhSAVYFehZabzff3tDsWv https://cassyni.com/slides/outline/7cETbeCDK81wPYQWB94YT7 https://cassyni.com/events/7cETbeCDK81wPYQWB94YT7/abstract https://cassyni-user-files-prod.s3.amazonaws.com/JKUsQ76kaQTa9LdqCoXy2N https://cassyni.com/events/7cETbeCDK81wPYQWB94YT7?videoPreview=1 Immunophenotypic changes following menin inhibition in acute myeloid leukemianohttps://cassyni.com/events/7cETbeCDK81wPYQWB94YT7?videoPreview=12026-04-08T15:01:33+00:001281.76LeukemiaMenin inhibition leads to an antileukemic effect through hematopoietic differentiation. Treatment with the menin inhibitor revumenib results in clinical remissions in relapsed or refractory (R/R) acute myeloid leukemia (AML) with either rearrangement of lysine methyltransferase 2A (KMT2A) or mutation in nucleophosmin 1 (NPM1), leading to regulatory approval of this drug. However, determinants of response to revumenib have not been fully elucidated. We examined the immunophenotype of leukemia cells by flow cytometry, in sequential bone marrow specimens from 48 patients with R/R AML treated with revumenib. We observed dynamic changes in the immunophenotype after treatment in 16 of 31 (52%) patients, characterized by a switch from a myeloid/stem-like to a monocytic or myelomonocytic immunophenotype, or vice versa, or by substantial changes in the intensity of antigen expression or in patterns of leukemia-associated immunophenotypes. Morphologic remission with undetectable measurable residual disease (MRD) by flow cytometry following revumenib was associated with improved overall survival, with a median of 23.6 months compared with 20.8 months in patients with morphologic response and detectable MRD, and 3.2 months in non-responders. In summary, treatment monitoring of AML by flow cytometry, following menin inhibition, requires recognition of phenotypic changes associated with differentiation. https://cassyni-user-files-prod.s3.amazonaws.com/JKUsQ76kaQTa9LdqCoXy2N https://cassyni.com/events/49hEGrfYEv9JMr6wXUgavH/abstract https://cassyni-user-files-prod.s3.amazonaws.com/cx5rjRZh2ZhjuQFEk8s42 https://cassyni.com/slides/outline/3fJEFqezRhvhKwKDfx4Jn1 https://cassyni.com/events/3fJEFqezRhvhKwKDfx4Jn1/abstract https://cassyni-user-files-prod.s3.amazonaws.com/RJbCGfRTPwU7qMBoqeXzhC https://cassyni.com/events/3fJEFqezRhvhKwKDfx4Jn1?videoPreview=1 Effective approach to open systems with probability currents and the Grothendieck formalismnohttps://cassyni.com/events/3fJEFqezRhvhKwKDfx4Jn1?videoPreview=12025-09-22T13:00:00+00:002096.84Annals of PhysicsAn effective approach to open systems and irreversible phenomena is presented, where an open system $\Sigma(d)$ with $d$-dimensional Hilbert space, is a subsystem of a larger isolated system $\Sigma(2d)$ (the `full universe') with $2d$-dimensional Hilbert space. A family of Bargmann-like representations (called $z$-Bargmann representations) introduces naturally the larger space. The $z$-Bargmann representations are defined through semi-unitary matrices (which are a coherent states formalism in disguise). The `openness' of the system is quantified with the probability current that flows from the system to the external world. The Grothendieck quantity ${\cal Q}$ is shown to be related to the probability current, and is used as a figure of merit for the `openness' of a system. ${\cal Q}$ is expressed in terms of `rescaling transformations' which change not only the phase but also the absolute value of the wavefunction, and are intimately linked to irreversible phenomena (e.g., damping/amplification). It is shown that unitary transformations in the isolated system $\Sigma(2d)$ (full universe), reduce to rescaling transformations when projected to its open subsystem $\Sigma(d)$. The values of the Grothendieck ${\cal Q}$ for various quantum states in an open system, are compared with those for their counterpart states in an isolated system.https://cassyni-user-files-prod.s3.amazonaws.com/RJbCGfRTPwU7qMBoqeXzhC https://cassyni.com/events/SsYeWvwZqLYaypudJ7V24D/seminar/qa https://cassyni.com/slides/outline/SsYeWvwZqLYaypudJ7V24D https://cassyni.com/events/SsYeWvwZqLYaypudJ7V24D/abstract https://cassyni-user-files-prod.s3.amazonaws.com/D16HSKAZpKcwgxfVk5DHZY https://cassyni.com/events/SsYeWvwZqLYaypudJ7V24D?videoPreview=1 Advances in Hybrid Metallurgical Processes for Recyclingnohttps://cassyni.com/events/SsYeWvwZqLYaypudJ7V24D?videoPreview=12026-06-19T16:00:00+00:003714.16JOM, The Journal of The Minerals, Metals & Materials SocietyThis topic focuses on recent advances in hybrid metallurgical processes that integrate hydrometallurgy, pyrometallurgy, and electrometallurgy for metal extraction and recycling of waste-derived materials. Particular emphasis will be placed on innovative process combinations, fundamental studies, and industrial applications that improve process efficiency, sustainability, and resource recovery. Contributions addressing critical and strategic metals, recycling of end-of-life products, and the role of hybrid approaches, supported by LCA and TEA, in advancing circular economy goals are particularly welcome.https://cassyni-user-files-prod.s3.amazonaws.com/D16HSKAZpKcwgxfVk5DHZY https://cassyni.com/slides/outline/7cYJrZrxk6Cw16emHDzjd7 https://cassyni.com/events/7cYJrZrxk6Cw16emHDzjd7/abstract https://cassyni-user-files-prod.s3.amazonaws.com/GRsk2g8K2vqP2mGPVkqQpE https://cassyni.com/events/7cYJrZrxk6Cw16emHDzjd7?videoPreview=1 LILRB4 regulates circadian disruption-induced mammary tumorigenesis via non-canonical WNT signaling pathwaynohttps://cassyni.com/events/7cYJrZrxk6Cw16emHDzjd7?videoPreview=12025-11-30T02:00:00+00:00615.92OncogeneEpidemiological studies have shown that circadian rhythm disruption (CRD) is associated with the risk of breast cancer. However, the role of CRD in mammary gland morphology and aggressive basal mammary tumorigenesis and the molecular mechanism underlying CRD-induced carcinogenesis remain unknown. To investigate the effect of CRD on aggressive tumorigenesis, a genetically engineered mouse model of aggressive breast cancer was used. The impact of CRD on the tumor microenvironment was investigated using the tumors from LD12:12 and CRD mice via scRNA-seq, flow cytometry, multiplexing immunostaining, and realtime PCR. The effect of LILRB4-immunotherapy on CRD-induced tumorigenesis was also investigated. Here we investigated and identified the impact of CRD on basal tumorigenesis and mammary gland morphology. We found that chronic CRD disrupted mammary gland morphology, increased lung metastasis, and induced an immunosuppressive tumor microenvironment by enhancing LILRB4 expression. Furthermore, targeted immunotherapy against LILRB4 reduced CRD-induced immunosuppressive microenvironment and lung metastasis. Finally, we showed that LILRB4 regulates CRD-induced mammary tumorigenesis via a non-canonical WNT signaling pathway. These findings identify and implicate LILRB4 as a link between CRD and aggressive mammary tumorigenesis and establish the potential role of the targeted LILRB4a immunotherapy as an inhibitor of CRD-induced lung metastasis.https://cassyni-user-files-prod.s3.amazonaws.com/GRsk2g8K2vqP2mGPVkqQpE https://cassyni.com/slides/outline/9b8j3JT4VvRh6ovzeBrg3f https://cassyni.com/events/9b8j3JT4VvRh6ovzeBrg3f/abstract https://cassyni-user-files-prod.s3.amazonaws.com/AwMe5AgpqhjiF1jhjLVGte https://cassyni.com/events/9b8j3JT4VvRh6ovzeBrg3f?videoPreview=1 Shape Matters: Advanced Computational Approaches to the Demagnetisation fields of Magnetic Assembliesnohttps://cassyni.com/events/9b8j3JT4VvRh6ovzeBrg3f?videoPreview=12025-11-26T13:00:00+00:002182.32Computer Physics CommunicationsAny magnetic sample creates an internal magnetic field that opposes magnetisation. This is caused by magnetic poles on the surface of the material. When making measurements on a magnetic sample, the sample’s self-demagnetisation field must be considered. The demagnetisation factor depends on the shape and consistency of the sample, such as solid and packed particulates etc. Current literature provides only a limited range of information on demagnetisation factors (restricted to certain shapes, sizes, and consistencies). The purpose of the algorithms created here is to provide demagnetisation factor information for any sample shape in an efficient and simple manner. The validity of the algorithms was tested by setting up simulations based on accepted data in the literature for discrete magnetic elements packed into either cuboids, ellipsoids, or cylinders. The mean demagnetisation factors found by the algorithms matched those found in the literature, typically within 0.05%, 0.1%, and 1%, respectively, for these shapes, demonstrating that the algorithms could be extrapolated to calculate demagnetisation data for any sample shape. https://cassyni-user-files-prod.s3.amazonaws.com/AwMe5AgpqhjiF1jhjLVGte https://cassyni.com/events/QQcUYSNh51xmVuLmSoGUYM/seminar/qa https://cassyni.com/slides/outline/QQcUYSNh51xmVuLmSoGUYM https://cassyni.com/events/QQcUYSNh51xmVuLmSoGUYM/abstract https://cassyni-user-files-prod.s3.amazonaws.com/HwzfcbN7FK3VtbfVpeea7g https://cassyni.com/events/QQcUYSNh51xmVuLmSoGUYM?videoPreview=1 Thromboinflammation is associated with high thrombotic risk in patients with newly diagnosed myeloproliferative neoplasmsnohttps://cassyni.com/events/QQcUYSNh51xmVuLmSoGUYM?videoPreview=12026-01-05T15:00:00+00:001229.28LeukemiaThrombotic risk assessment is crucial in newly diagnosed essential thrombocythemia (ET) and polycythemia vera (PV) patients to guide cytoreductive therapy. We assessed whether thromboinflammation biomarkers would be good candidates to improve thrombosis risk stratification. We prospectively enrolled 394 newly diagnosed, cytoreductive therapy–naïve, ET and PV patients. We measured seven plasma biomarkers of neutrophil, monocyte, platelet, and endothelial activation, including NET markers, and evaluated their association with thrombosis risk scores at diagnosis. Multivariable analysis in the whole MPN cohort showed elevated calprotectin and tissue factor levels in high-risk versus low-risk patients using the conventional two-tiered score. This was also observed in ET patients only, but not in PV patients. Patients with a JAK2V617F allele burden >20% showed higher levels of three markers, including calprotectin, supporting its role in immunothrombosis. In PV patients, calprotectin correlated with the Venous Thrombosis Score (VETS), and five markers were elevated in those with prior venous thrombosis. Lastly, aspirin use was associated with lower H3Cit levels in patients with normal platelet counts, confirming its beneficial effect on NET formation. This is the largest study to date linking thromboinflammation markers to thrombotic risk in MPN patients and identifying potential biomarkers for future thrombosis risk scores.https://cassyni-user-files-prod.s3.amazonaws.com/HwzfcbN7FK3VtbfVpeea7g https://cassyni.com/slides/outline/Ur5pUQVtnSuXNphGm8LEyK https://cassyni.com/events/Ur5pUQVtnSuXNphGm8LEyK/abstract https://cassyni-user-files-prod.s3.amazonaws.com/38wBR2X7xwTcNnbzf78Kf4 https://cassyni.com/events/Ur5pUQVtnSuXNphGm8LEyK?videoPreview=1 Compounding the Problem: Conserved optical adaptations enable amphibious vision in compound eyesnohttps://cassyni.com/events/Ur5pUQVtnSuXNphGm8LEyK?videoPreview=12026-03-03T13:00:00+00:001449.56Royal Society PublishingAnimal visual systems evolve to meet the ecological demands of their users. Though the physics of light is a major force driving the evolution of animal eye optics, our understanding of the interplay between evolutionary selection from environmental medium vs. ecological demands is limited, especially for animals with compound eyes. While previous work established that multiple ecological factors, including environmental medium, shape the evolution of optical performance in compound eyes, it remained to be established how compound eyes are adapted to support vision in animals with amphibious ecologies. Our recent publication investigates the corneal morphology, optics, and visual behavior of amphibious insects, revealing three morphological adaptations that are selected upon in compound eyes to yield amphibious performance. Similar patterns of changes to the corneal morphology and optical performance were found both across the development of a single insect species (Belostomatid) as well as among closely related and diverse arthropod lineages with amphibious ecologies. Taken together, this work demonstrates how simply living in either air or water (or both) profoundly shapes the optical performance of compound eyes.https://cassyni-user-files-prod.s3.amazonaws.com/38wBR2X7xwTcNnbzf78Kf4 https://cassyni.com/slides/outline/Mw4c46UKSm1HXQcwo2ReeR https://cassyni.com/events/Mw4c46UKSm1HXQcwo2ReeR/abstract https://cassyni.com/events/Mw4c46UKSm1HXQcwo2ReeR?videoPreview=1 More smarts, more song: Male chickadees with better spatial learning and memory abilities sing more throughout the daynohttps://cassyni.com/events/Mw4c46UKSm1HXQcwo2ReeR?videoPreview=12026-06-01T05:00:00+00:00705.0Royal Society PublishingCognitive abilities are critical for the survival of many species, as they allow for adaptive responses to variable environments. While many studies have focused on investigating the associations between cognition and survival, few studies have investigated whether cognition is under sexual selection. Song is an established component of sexual selection and territory defense in passerines. Female songbirds use song to evaluate male quality to increase offspring fitness. Females could potentially benefit from using songs to identify males with high cognitive performance. Mountain chickadees rely on spatial memory to forage in unpredictable environments and on song to defend their territories. We compared the daily singing routines of male mountain chickadees that performed highly on a spatial memory task to males with relatively low task performance. We found that males with superior spatial memory had a higher song output than males with poorer spatial memory. Our results suggest that overall song output may be an indicator of cognitive ability, as a measure of quality, in mountain chickadees. https://cassyni.com/slides/outline/SNu3UFJ3PszXz4NjhgCDnu https://cassyni.com/events/SNu3UFJ3PszXz4NjhgCDnu/abstract https://cassyni-user-files-prod.s3.amazonaws.com/ENGW4XVvi242WJHeSKkd4i https://cassyni.com/events/SNu3UFJ3PszXz4NjhgCDnu?videoPreview=1 Age-specific patterns of reproductive success in wild female Eurasian lynx across Europenohttps://cassyni.com/events/SNu3UFJ3PszXz4NjhgCDnu?videoPreview=12026-04-30T09:00:00+00:00806.68Royal Society PublishingReproductive lifespan and age-specific reproductive performance are key life-history traits, shaping individual fitness and population dynamics. Here, we examine age-specific variation in reproductive success in a wild large carnivore, the Eurasian lynx (Lynx lynx), using 38 years of longitudinal data from 173 known-age females across Europe and western Asia. Female lynx exhibited age-related reproductive patterns: (i) breeding probability increased with age before declining at older ages, (ii) litter size remained generally stable at two kittens, although it declined to one kitten in older mothers at northern latitudes, and (iii) offspring survival peaked at intermediate female ages, with variation across individuals, years, and latitudes. These patterns likely reflect physiological maturation and increased experience (ages two to eight), followed by declines due to reproductive and maternal effect senescence in older females. Temporal and latitudinal variations suggest that environmental conditions shape reproductive patterns in Eurasian lynx, with senescence particularly pronounced in resource-scarce environments. Our findings enhance the understanding of age-related reproductive patterns in carnivores across environmental contexts, contributing to life-history theory, and improve evidence-based management by accounting for age structure in population forecasting.https://cassyni-user-files-prod.s3.amazonaws.com/ENGW4XVvi242WJHeSKkd4i https://cassyni.com/slides/outline/QtyrSpsMUsFvSf1RWNJgjf https://cassyni.com/events/QtyrSpsMUsFvSf1RWNJgjf/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Sh77MQsEEjVLEU3G6TUaQE https://cassyni.com/events/QtyrSpsMUsFvSf1RWNJgjf?videoPreview=1 Evolutionary time drives the inverse latitudinal diversity gradient of New World Sparrows (Aves: Passerellidae)nohttps://cassyni.com/events/QtyrSpsMUsFvSf1RWNJgjf?videoPreview=12026-06-15T22:00:00+00:001007.32Royal Society PublishingThe Latitudinal Diversity Gradient is a classic pattern in which the tropics harbour the greatest number of species. Deviations from this pattern, such as an inverse gradient in which diversity is higher towards the poles, are often considered taxon-specific rather than the result of general processes. We examined how evolutionary and ecological factors shape geographic diversity in New World sparrows (Aves: Passerellidae) at both family and lower clade levels. Our findings indicate an 'into the tropics' colonisation pattern, with sparrows originating and primarily persisting in temperate zones, while limited dispersal has led to high diversification in the tropics.https://cassyni-user-files-prod.s3.amazonaws.com/Sh77MQsEEjVLEU3G6TUaQE https://cassyni.com/events/86wJsasWZJRY31SV8kd1mP/abstract https://cassyni-user-files-prod.s3.amazonaws.com/XFa1ExqX1q5ou6vY8xbuXc https://cassyni.com/events/LwpeBzD3NZkVoUF9Ppf5mP/abstract https://cassyni-user-files-prod.s3.amazonaws.com/HjpZZ97DqskqrKSY1ogm6N https://cassyni.com/slides/outline/G1Lbj9jnyzDCM3xTtjbiMb https://cassyni.com/events/G1Lbj9jnyzDCM3xTtjbiMb/abstract https://cassyni-user-files-prod.s3.amazonaws.com/EvL1k7XLUE9vJfaXPDKCpW https://cassyni.com/events/G1Lbj9jnyzDCM3xTtjbiMb?videoPreview=1 From individual thresholds to collective hysteresis: a mechanistic model of the dawn chorusnohttps://cassyni.com/events/G1Lbj9jnyzDCM3xTtjbiMb?videoPreview=12026-07-29T11:00:00+00:002218.92Royal Society PublishingAt dawn, many bird communities exhibit a rapid and highly synchronous transition from silence to vocal activity. Although light levels increase gradually, the onset of this dawn chorus can appear abrupt, suggesting the possibility of tipping behaviour. While such dynamics are frequently described using catastrophe theory, direct mechanistic links between individual behavioural rules and macroscopic bifurcation structure remain limited. We develop a stochastic threshold model for this phenomenon in which each individual sings when a combination of light and social stimulation exceeds its activation threshold. Under mean-field scaling, the population dynamics converge to a deterministic equation for the proportion of singing individuals, with nonlinearity determined entirely by the cumulative distribution of thresholds. We show that for a broad class of threshold distributions, this system exhibits cusp bifurcations and hysteresis. Thus, the abrupt onset of singing can emerge directly from heterogeneity and social feedback, without imposing nonlinearities at the population level. Extending the model to spatially structured populations yields travelling waves, providing an explanation for the spatial variation of song across a landscape. Our results demonstrate how heterogeneity in behavioural thresholds can generate hysteresis in socially coupled populations, offering a general framework for linking individual decision rules to emergent ecological transitions.https://cassyni-user-files-prod.s3.amazonaws.com/EvL1k7XLUE9vJfaXPDKCpW https://cassyni.com/slides/outline/E4K3wg1KnMsVtGTFZ6K1MP https://cassyni.com/events/E4K3wg1KnMsVtGTFZ6K1MP/abstract https://cassyni-user-files-prod.s3.amazonaws.com/6buf2Qr6UM8TQqtS2zoxWr https://cassyni.com/events/E4K3wg1KnMsVtGTFZ6K1MP?videoPreview=1 Indicators For Open Research: Pilot Projectsnohttps://cassyni.com/events/E4K3wg1KnMsVtGTFZ6K1MP?videoPreview=12024-03-14T03:00:00+00:005495.16UKRNThis webinar presented work being coordinated via the UKRN Open Research Programme, to explore and develop indicators of open research. The webinar follows one in March 2023 that launched a call for sector priorities on which aspects of open research should be monitored. Since then, those priorities have been agreed, and a group of 15 UK institutions and five solution providers has come together to run pilot projects on monitoring FAIR and open data and their effects, the use of data availability statements, preregistration and the use of the CRediT taxonomy. In this webinar, the leads of several of those pilots will join Neil Jacobs to outline their ambitions and challenges, and to discuss these with you.https://cassyni-user-files-prod.s3.amazonaws.com/6buf2Qr6UM8TQqtS2zoxWr https://cassyni.com/events/6droH3uQj7UmayEWCcSTJ5/seminar/qa https://cassyni.com/slides/outline/6droH3uQj7UmayEWCcSTJ5 https://cassyni.com/events/6droH3uQj7UmayEWCcSTJ5/abstract https://cassyni-user-files-prod.s3.amazonaws.com/D5BptWUPEQSi8anmWrYj1p https://cassyni.com/events/6droH3uQj7UmayEWCcSTJ5?videoPreview=1 CFDnohttps://cassyni.com/events/6droH3uQj7UmayEWCcSTJ5?videoPreview=12023-06-14T14:30:00+00:005187.08NEKTAR++No abstracthttps://cassyni-user-files-prod.s3.amazonaws.com/D5BptWUPEQSi8anmWrYj1p