https://cassyni.com/events/8VQJf8eAz2G3StTdDVEXbB/abstract https://cassyni-user-files-prod.s3.amazonaws.com/KEebuqFgyeX9WhaR3ERKN6 https://cassyni.com/events/RHJjfE4atnTo7qxiCRcfBB/seminar/qa https://cassyni.com/slides/outline/RHJjfE4atnTo7qxiCRcfBB https://cassyni.com/events/RHJjfE4atnTo7qxiCRcfBB/abstract https://cassyni-user-files-prod.s3.amazonaws.com/LqFsKxPAeKyQseeerTQ9ki https://cassyni.com/events/RHJjfE4atnTo7qxiCRcfBB?videoPreview=1 Passive vibration energy management through intentional nonlinearitynohttps://cassyni.com/events/RHJjfE4atnTo7qxiCRcfBB?videoPreview=12023-09-27T14:00:00+00:002613.48Nonlinear Dynamics, an International Journal of Nonlinear Dynamics and Chaos in Engineering SystemsIn essence, nonlinearity is a dynamical mechanism for scattering vibration energy across temporal or spatial scales (e.g., frequencies / wavenumbers, or system modes). Moreover, nonlinear effects are highly tunable with (or passively adaptive to) energy and other system parameters, a feature which enables new and unprecedented passive multi-functionality in engineering systems. This contrasts to linear systems where no such passive effects can be induced given their lack of capacity for multi-frequency harmonic generation. Engineering nonlinearity, therefore, has become an interesting and potentially transformative emerging trend, with great promise for the future. In this talk we present our vision regarding this exciting new field, by overviewing some basic elements of nonlinear energy management in vibration engineering. This includes, capacity for targeted energy transfers (TET) to nonlinear energy sinks; intermodal TET in structural systems, and interband TET in phononic systems; energy redirection in preferential directions; affecting and tuning the nonlinear bandwidth of nonlinear oscillators through multi-harmonic energy scattering; enhanced vibration and shock isolation; nonlinear vibration energy harvesting; rapid and effective inherent dissipation, and other effects. Predictively and reliably engineering nonlinear effects for energy management dictates a comprehensive physics-based understanding of multi-scale complex processes and phenomena, accompanied with powerful computational tools and rigorous experimental validation. Hence, the discussed nonlinear concepts and methods need to be closely tied to physical insight and progress in modern computational techniques such as machine learning. Moreover, unwanted nonlinear effects such as instabilities, uncontrollable chaotic responses or unwanted co-existing dynamics, just to name a few, need to be avoided by careful predictive design. Through two examples we demonstrate the efficacy of engineering nonlinearity in oscillating systems to induce new, heretofore unavailable features in dynamical systems in predictable and controllable ways.https://cassyni-user-files-prod.s3.amazonaws.com/LqFsKxPAeKyQseeerTQ9ki https://cassyni.com/events/15Y8PjMsPMKtxACsGeKMkq/abstract https://cassyni-user-files-prod.s3.amazonaws.com/4FNtZjNrCuJRGJSCNY7bGr https://cassyni.com/events/3Yn9d9bVae6PK6gRpLDzUm/seminar/qa https://cassyni.com/events/3Yn9d9bVae6PK6gRpLDzUm/abstract https://cassyni-user-files-prod.s3.amazonaws.com/X5sjuArKfN81SFduAD2pBx https://cassyni.com/events/3Yn9d9bVae6PK6gRpLDzUm?videoPreview=1 Logic in tolkāppiyam (chapter of the book)nohttps://cassyni.com/events/3Yn9d9bVae6PK6gRpLDzUm?videoPreview=12023-03-22T15:00:00+00:005233.96Logica UniversalisTolkāppiyam shows us that logic had an important place in the primal society (known as tiṇai). Such primal cultural practices as “tarukkam,” “vākai,” analogical reasoning, the use of the criteria of knowledge (“aḷavai”) in premarital life situations and in oral texts (such as mutumoḻi and kāṇṭikai), and also the primal social institution, namely, the assembly (avai) where public debates were held, were all part of the philosophical tradition of this society. Such philosophy embraced logic, which had rhetorical as well as epistemic functions. If rhetorical logic was persuasive (as in tarukkam) and contestatory (as in vākai in combat and in the assembly), epistemic logic (aḷavai) was validative. In fact, early Tamil logic was a complex discipline not easily distinguishable from philosophy (especially, epistemology and ethics) and rhetoric.https://cassyni-user-files-prod.s3.amazonaws.com/X5sjuArKfN81SFduAD2pBx https://cassyni.com/events/ATrcGieqj3rAoug1BmnvdT/seminar/qa https://cassyni.com/slides/outline/ATrcGieqj3rAoug1BmnvdT https://cassyni.com/events/ATrcGieqj3rAoug1BmnvdT/abstract https://cassyni-user-files-prod.s3.amazonaws.com/DKWdQrJ9T8iky5SKmd8zHc https://cassyni.com/events/ATrcGieqj3rAoug1BmnvdT?videoPreview=1 Efficient Implementations of High-Order Finite Elements with the deal.II Librarynohttps://cassyni.com/events/ATrcGieqj3rAoug1BmnvdT?videoPreview=12023-06-14T12:45:00+00:004082.84NEKTAR++My talk will present experiences and insights from the development of high-performance matrix-free operator evaluation algorithms with the deal.II finite element library. Originally, our efforts have concentrated on hexahedral finite elements, where integrals can be computed very efficiently with sum factorization techniques, but we have also looked into other element shapes recently, motivated by encouraging results from the Nektar++ team. The resulting implementations come with an arithmetic intensity of one to five Flop/byte, with memory transfer primarily due to the access into input and output vectors as well as some geometry or variable coefficient data. This enables a cost per degree of freedom that is almost constant for a broad range of polynomial degrees of cell and face integrals of high order continuous and discontinuous finite elements, and allows to select the polynomial degree as a parameter to trade against mesh generation limitations. From a hardware perspective, the Flop/byte ratio suggests that memory bandwidth is the main performance limit on many CPU and GPU architectures. Furthermore, many downstream solvers, such as multigrid smoothers, explicit time stepping, or conjugate gradient solvers, are now no longer dominated by the matrix-vector products, and vector operations need to be explicitly taken into consideration as well. My talk will show the effect of algorithmic optimizations on fluid dynamics simulations on massively parallel computers.https://cassyni-user-files-prod.s3.amazonaws.com/DKWdQrJ9T8iky5SKmd8zHc https://cassyni.com/events/ML9XQPQGnUxNUfCS5sy4Cu/seminar/qa https://cassyni.com/slides/outline/ML9XQPQGnUxNUfCS5sy4Cu https://cassyni.com/events/ML9XQPQGnUxNUfCS5sy4Cu/abstract https://cassyni-user-files-prod.s3.amazonaws.com/LWqKDmU3gsWfpZybiEzZUi https://cassyni.com/events/ML9XQPQGnUxNUfCS5sy4Cu?videoPreview=1 Half a century of evolutionary gamesnohttps://cassyni.com/events/ML9XQPQGnUxNUfCS5sy4Cu?videoPreview=12023-05-24T10:00:00+00:003947.32Royal Society PublishingEvolutionary game theory (EGT) is an indispensable part of modern evolutionary theory. 2023 marks the 50th anniversary of the article by John Maynard Smith and George Price that defined central concepts and became a focal point in the field. EGT can address biological questions where there is no obvious “best thing” that an individual can do, because their payoff depends not only on what they do but also on what their ‘opponents’ do. In the last 50 years, EGT has expanded and become integrated with a range of other theoretical methods. A recent theme issue reviewed the history and methodology of the field and presented novel research. In this seminar, some of the authors from the issue will talk about the topic and their papers. https://cassyni-user-files-prod.s3.amazonaws.com/LWqKDmU3gsWfpZybiEzZUi https://cassyni.com/slides/outline/PJiKUVUV8xF328gUqTkikd https://cassyni.com/events/PJiKUVUV8xF328gUqTkikd/abstract https://cassyni-user-files-prod.s3.amazonaws.com/PWF7ewt2HLzHdjTfdCJvyc https://cassyni.com/events/PJiKUVUV8xF328gUqTkikd?videoPreview=1 Machine Learning for Computational Fluid Dynamicsnohttps://cassyni.com/events/PJiKUVUV8xF328gUqTkikd?videoPreview=12021-11-18T12:00:00+00:002353.64Brunton LabMachine learning is rapidly becoming a core technology for scientific computing, with numerous opportunities to advance the field of computational fluid dynamics. This paper highlights some of the areas of highest potential impact, including to accelerate direct numerical simulations, to improve turbulence closure modeling, and to develop enhanced reduced-order models. In each of these areas, it is possible to improve machine learning capabilities by incorporating physics into the process, and in turn, to improve the simulation of fluids to uncover new physical understanding. Despite the promise of machine learning described here, we also note that classical methods are often more efficient for many tasks. We also emphasize that in order to harness the full potential of machine learning to improve computational fluid dynamics, it is essential for the community to continue to establish benchmark systems and best practices for open-source software, data sharing, and reproducible research.https://cassyni-user-files-prod.s3.amazonaws.com/PWF7ewt2HLzHdjTfdCJvyc https://cassyni.com/slides/outline/KrB69hwp4kNPzSNvBoNmDo https://cassyni.com/events/KrB69hwp4kNPzSNvBoNmDo/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Rif8Jh1w1Qp4bCV9gY1v4n https://cassyni.com/events/KrB69hwp4kNPzSNvBoNmDo?videoPreview=1 Q-Learning: Model Free Reinforcement Learning and Temporal Difference Learningnohttps://cassyni.com/events/KrB69hwp4kNPzSNvBoNmDo?videoPreview=12022-01-14T12:00:00+00:002134.52Brunton LabHere we describe Q-learning, which is one of the most popular methods in reinforcement learning. Q-learning is a type of temporal difference learning. We discuss other TD algorithms, such as SARSA, and connections to biological learning through dopamine. Q-learning is also one of the most common frameworks for deep reinforcement learning.https://cassyni-user-files-prod.s3.amazonaws.com/Rif8Jh1w1Qp4bCV9gY1v4n https://cassyni.com/events/WiSPAkBMipYsWiCwoLcTAd/abstract https://cassyni-user-files-prod.s3.amazonaws.com/YCtfTCWHVRzADbDu5SFXUA https://cassyni.com/slides/outline/8VGC5z4jyDdQiCPmpovzCu https://cassyni.com/events/8VGC5z4jyDdQiCPmpovzCu/abstract https://cassyni-user-files-prod.s3.amazonaws.com/RmjcswhRK6hzgnemUSQBpA https://cassyni.com/events/8VGC5z4jyDdQiCPmpovzCu?videoPreview=1 Nature Water Talks: waiting for the UN Water Conferencenohttps://cassyni.com/events/8VGC5z4jyDdQiCPmpovzCu?videoPreview=12023-03-15T19:00:00+00:003648.6Nature WaterThe first global conference on water in almost 50 years will be held at the UN headquarters in New York on March 22-24. Please join us for a conversation with Quentin Grafton (Australian National University), Joyeeta Gupta (University of Amsterdam), John Matthews (AGWA), and Rachael McDonnell (IWMI) about expectations of this global event and about challenges and opportunities on the road ahead. The webinar will be 7pm London time, which is 3pm US Eastern Time this weekhttps://cassyni-user-files-prod.s3.amazonaws.com/RmjcswhRK6hzgnemUSQBpA https://cassyni.com/slides/outline/FtzFnEmcZ5wFCmvEngnicu https://cassyni.com/events/FtzFnEmcZ5wFCmvEngnicu/abstract https://cassyni-user-files-prod.s3.amazonaws.com/DGJ4qi5rexfVQydkwBdWDL https://cassyni.com/events/FtzFnEmcZ5wFCmvEngnicu?videoPreview=1 Anthromes, CO2 and Terrestrial Carbon – Session 10: How to maximize terrestrial ecosystem carbon and increase global equitynohttps://cassyni.com/events/FtzFnEmcZ5wFCmvEngnicu?videoPreview=12023-03-30T17:30:00+00:004186.0The New Phytologist Foundation1.30 - 1.50: Tropical forest carbon in an unequal world: a social science perspective, Vera Ehrenstein - Due to technical difficulties Vera's presentation will be re-recorded and posted at a later date. 1.50 - 2.10: Future forest growth in the UK – a case study of supporting land use decisions for net zero, Anna Harper 2.10 - 2.30: Showcasing NASA GEDI mission data for aboveground carbon monitoring and evaluation of carbon losses from LULC events, Adrian Pasqual 2.30 - 3.00: Realizing Rights, Securing Climate Outcomes, Alain Frechette https://cassyni-user-files-prod.s3.amazonaws.com/DGJ4qi5rexfVQydkwBdWDL https://cassyni.com/slides/outline/AxWDKQJNAWQDogCtnD5itm https://cassyni.com/events/AxWDKQJNAWQDogCtnD5itm/abstract https://cassyni-user-files-prod.s3.amazonaws.com/NwgaPyX7WcV4VvUKq8NmU https://cassyni.com/events/AxWDKQJNAWQDogCtnD5itm?videoPreview=1 Physical Computation in Insect Swarmsnohttps://cassyni.com/events/AxWDKQJNAWQDogCtnD5itm?videoPreview=12022-10-27T09:00:00+00:003532.0Journal of Biological PhysicsOur world is full of living creatures that must share information to survive and reproduce. As humans, we easily forget how hard it is to communicate within natural environments. So how do organisms solve this challenge, using only natural resources? Ideas from computer science, physics and mathematics, such as energetic cost, compression, and detectability, define universal criteria that almost all communication systems must meet. We use insect swarms as a model system for identifying how organisms harness the dynamics of communication signals, perform spatiotemporal integration of these signals, and propagate those signals to neighboring organisms. In this talk I will focus on three types of communication in insect swarms: visual communication, in which fireflies communicate over long distances using light signals, chemical communication, in which bees serve as signal amplifiers to propagate pheromone-based information about the queen’s location, and mechanical communication in which bees sense tensions in the physical bonds they make to create clusters that change their morphology to withstand mechanical stresses. These evolved solutions reveal new optimalities in the physics of spatiotemporal signal processing. By understanding insect communication – honed by evolution, selection, and refinement – we can expect to not only more deeply understand animal communication but leverage that understanding toward bio-inspired designs in the fields of swarm robotics and distributed communication.https://cassyni-user-files-prod.s3.amazonaws.com/NwgaPyX7WcV4VvUKq8NmU https://cassyni.com/events/TkaP1Gp6VSA4JUttwnMTp1/seminar/qa https://cassyni.com/slides/outline/TkaP1Gp6VSA4JUttwnMTp1 https://cassyni.com/events/TkaP1Gp6VSA4JUttwnMTp1/abstract https://cassyni-user-files-prod.s3.amazonaws.com/XYuBk5ZpDaUfQAzKs2tyBt https://cassyni.com/events/TkaP1Gp6VSA4JUttwnMTp1?videoPreview=1 Holomorphic functions of finite order generated by Dirichlet seriesnohttps://cassyni.com/events/TkaP1Gp6VSA4JUttwnMTp1?videoPreview=12023-07-06T09:00:00+00:003115.36Banach Journal of Mathematical AnalysisGiven a frequency $\lambda = (\lambda_n)$ and $\ell \ge 0$, we introduce the scale of Banach spaces $H_{\infty,\ell}^{\lambda}[Re > 0]$ of holomorphic functions $f$ on the open right half-plane $[Re > 0]$, which satisfy $(A)$ the growth condition $|f(s)| = O((1 + |s|)^\ell)$, and $(B)$ have a Riesz germ, i.e. on some open subset and for some $m \ge 0$ the function $f$ coincides with the pointwise limit (as $x \to \infty$) of the so-called $(\lambda,m)$-Riesz means $\sum_{\lambda_n < x} a_n e^{-\lambda_n s}\big( 1-\frac{\lambda_n}{x}\big)^m ,\,x >0$ of some $\lambda$-Dirichlet series $\sum a_n e^{-\lambda_n s}$. Reformulated in our terminology, an important result of M. Riesz shows that in this case the function $f$ for every $k >\ell$ is the pointwise limit of the $(\lambda,k)$-Riesz means of $D$ on $[Re > 0]$. Our main contribution is an extension -- showing that 'after translation' every bounded set in $H_{\infty,\ell}^{\lambda}[Re > 0]$ is uniformly approximable by all its $(\lambda,k)$-Riesz means of order $k>\ell$. This follows from an appropriate maximal theorem, which in fact turns out to be at the very heart of a seemingly interesting structure theory of the Banach spaces $H_{\infty,\ell}^{\lambda}Re > 0]$. One of the many consequences is that $H_{\infty,\ell}^{\lambda}[Re > 0]$ basically consists of those holomorphic functions on $[Re >0]$, which have a Riesz germ and are of finite uniform order $\ell$ on $[Re >0]$. To establish all this and more, we need to reorganize (and to improve) various aspects and keystones of the classical theory of Riesz summability of general Dirichlet series as invented by Hardy and M. Riesz. Joint work with Ingo Schoolmann. https://cassyni-user-files-prod.s3.amazonaws.com/XYuBk5ZpDaUfQAzKs2tyBt https://cassyni.com/slides/outline/6WhQ1szXckLkAiuj5E9KfB https://cassyni.com/events/6WhQ1szXckLkAiuj5E9KfB/abstract https://cassyni-user-files-prod.s3.amazonaws.com/VpWLcQQqUZpvN2enrtV5hG https://cassyni.com/events/6WhQ1szXckLkAiuj5E9KfB?videoPreview=1 Large language model artificial intelligence: the current state and future of ChatGPT in neuro-oncology publishingnohttps://cassyni.com/events/6WhQ1szXckLkAiuj5E9KfB?videoPreview=12023-06-12T20:00:00+00:001891.88Journal of Neuro-OncologyJoin Dr. Randy D'Amico and Dr. Jason Sheehan from the Journal of Neuro-Oncology for a discussion with Dr. Christopher P. Cifarelli from West Virginia University about his latest article on the current state and future of ChatGPT in neuro-oncology publishing.https://cassyni-user-files-prod.s3.amazonaws.com/VpWLcQQqUZpvN2enrtV5hG https://cassyni.com/events/71M14Ze44CtoAVScffS7vV/seminar/qa https://cassyni.com/slides/outline/71M14Ze44CtoAVScffS7vV https://cassyni.com/events/71M14Ze44CtoAVScffS7vV/abstract https://cassyni-user-files-prod.s3.amazonaws.com/53dRKJ8Qmgq5WFazKtPyYS https://cassyni.com/events/71M14Ze44CtoAVScffS7vV?videoPreview=1 Quantum simulation of ODEs, PDEs and related problems. Part I: Schrodingerisation of linear systemsnohttps://cassyni.com/events/71M14Ze44CtoAVScffS7vV?videoPreview=12023-11-06T15:00:00+00:004284.68Journal of Computational PhysicsOne of the oldest and currently most promising application areas for quantum devices is quantum simulation. Popularised by Feynman in the early 1980s, it is important for the efficient simulation – compared to its classical counterpart – of one special partial differential equation (PDE): Schrodinger’s equation. This is possible because quantum devices themselves naturally obey Schrodinger’s equation. Just like with large-scale quantum systems, classical methods for other high-dimensional and large-scale PDEs often suffer from the curse-of-dimensionality, which a quantum treatment might in certain cases be able to mitigate. Aside from Schrodinger’s equation, can quantum simulators also efficiently simulate other PDEs? To enable the simulation of PDEs on quantum devices that obey Schrodinger’s equations, it is crucial to first develop good methods for mapping other PDEs onto Schrodinger’s equations. After a brief introduction to quantum simulation, I will address the above question in this talk by introducing a simple and natural method for mapping other linear PDEs onto Schrodinger’s equations. It turns out that by transforming a linear partial differential equation (PDE) into a higher-dimensional space, it can be transformed into a system of Schrodinger’s equations, which is the natural dynamics of quantum devices. This new method – called Schrodingerisation – thus allows one to simulate, in a simple way, any general linear partial differential equation and system of linear ordinary differential equations via quantum simulation. This simple methodology is also very versatile. It can be used directly either on discrete-variable quantum systems (qubits) or on analog/continuous quantum degrees of freedom (qumodes). The continuous representation in the latter case can be more natural for PDEs since, unlike most computational methods, one does not need to discretise the PDE first. In this way, we can directly map D-dimensional linear PDEs onto a (D + 1)-qumode quantum system where analog Hamiltonian simulation on (D + 1) qumodes can be used. It is the quantum version of analog computing and is more amenable to near-term realisation. I will show how this Schrodingerisation method can be applied to linear PDEs, systems of linear ODEs and also linear PDES with random coefficients, where the latter is important in the area of uncertainty quantification. Furthermore, these methods can be extended to solve problems in linear algebra by transforming iterative methods in linear algebra into the evolution of linear ODEs. https://cassyni-user-files-prod.s3.amazonaws.com/53dRKJ8Qmgq5WFazKtPyYS https://cassyni.com/events/DvRTi8hQCceafJSC37145B/seminar/qa https://cassyni.com/slides/outline/DvRTi8hQCceafJSC37145B https://cassyni.com/events/DvRTi8hQCceafJSC37145B/abstract https://cassyni-user-files-prod.s3.amazonaws.com/VYnyTdh9GTrbma4GBU4T6n https://cassyni.com/events/DvRTi8hQCceafJSC37145B?videoPreview=1 Session 1: The DEFINE Study (for Clinical Trialists and Methodologists)nohttps://cassyni.com/events/DvRTi8hQCceafJSC37145B?videoPreview=12023-07-14T09:30:00+00:001778.72Institute for Cancer ResearchNo abstracthttps://cassyni-user-files-prod.s3.amazonaws.com/VYnyTdh9GTrbma4GBU4T6n https://cassyni.com/events/8ywRFJE9p37ZGCir2dJ4M3/seminar/qa https://cassyni.com/slides/outline/8ywRFJE9p37ZGCir2dJ4M3 https://cassyni.com/events/8ywRFJE9p37ZGCir2dJ4M3/abstract https://cassyni-user-files-prod.s3.amazonaws.com/VJUFiVEqSu2PX3VxYWHkcv https://cassyni.com/events/8ywRFJE9p37ZGCir2dJ4M3?videoPreview=1 Image Generationnohttps://cassyni.com/events/8ywRFJE9p37ZGCir2dJ4M3?videoPreview=12023-07-25T18:30:00+00:003787.8SCIWRITERAt Visual Abstract we have developed a novel format to present medical research results, the so-called **interactive Visual Abstract**. **What is the session about?** Learn how to use **interactive Visual Abstracts** to combine the power of an intuitive summary with the capability to display in-depth information. We will discuss how animations can give research special visibility, e.g. at scientific conferences and fairs. Finally, we will talk about how to use **interactive Visual Abstracts** to reach multiple audiences at once. We believe that in the upcoming years, AI-generated content will enable several digital and interactive formats like the **interactive Visual Abstract**. Together, these formats will heavily influence traditional ways of science communication. Join Dr. Dror Kolodkin-Gal as he unveils Proofig, an AI-based, all-in-one solution designed to streamline the process of image proofing in scientific publications. Learn how Proofig not only helps you maintain the highest standards of image integrity but also saves valuable time and reduces the potential for human errors. Tailored for scientists and editors alike, this presentation will shed light on the advanced technology powering Proofig AI, providing a comprehensive, one-stop solution for your image proofing needs. Eager to learn more? Click [here](https://www.proofig.com/) to delve deeper into the future of scientific image proofing.https://cassyni-user-files-prod.s3.amazonaws.com/VJUFiVEqSu2PX3VxYWHkcv https://cassyni.com/slides/outline/Jrw8HbgXzZ7cGW17nbcCLm https://cassyni.com/events/Jrw8HbgXzZ7cGW17nbcCLm/abstract https://cassyni-user-files-prod.s3.amazonaws.com/DjmWMJeYtKKZ9miMcLhp1t https://cassyni.com/events/Jrw8HbgXzZ7cGW17nbcCLm?videoPreview=1 Scitenohttps://cassyni.com/events/Jrw8HbgXzZ7cGW17nbcCLm?videoPreview=12023-03-20T17:00:00+00:003381.48DeSci FoundationIn this seminar, Josh covered questions like: What's wrong with citations? How can they be better? As well as: How does the scientific community react to disruptive ideas? Is this ecosystem – the cutting edge of knowledge – actually supportive of innovation?https://cassyni-user-files-prod.s3.amazonaws.com/DjmWMJeYtKKZ9miMcLhp1t https://cassyni.com/slides/outline/Rn1awAjt8xsPmJzhA3B8VT https://cassyni.com/events/Rn1awAjt8xsPmJzhA3B8VT/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Hm3Fn1mwr8UpNgnQr8jPMY https://cassyni.com/events/Rn1awAjt8xsPmJzhA3B8VT?videoPreview=1 DB/OS Co-Design in the MxKernel Projectnohttps://cassyni.com/events/Rn1awAjt8xsPmJzhA3B8VT?videoPreview=12023-09-11T15:00:00+00:002367.48HiPEDS CentreBetter integrating layers in the system software stack is seen as a promising way to leverage the potential of modern hardware technologies. In my talk I will describe our vision in the MxKernel project to make the co-design of databases and operating systems real. In MxKernel fundamentally change the process abstraction from threads to “tasks.” Tasks represent small units of work, rather than (lengthy) pieces of control flow. This makes them a better abstraction to enrich them with information about application characteristics. In the talk I will illustrate how this enables (a) automatic data prefetching by the task scheduler and (b) synchronization in multi-core environments with less developer effort, yet lower contention during execution.https://cassyni-user-files-prod.s3.amazonaws.com/Hm3Fn1mwr8UpNgnQr8jPMY https://cassyni.com/events/UFFcAayWLFdt8FUFhj5mDP/seminar/qa https://cassyni.com/slides/outline/UFFcAayWLFdt8FUFhj5mDP https://cassyni.com/events/UFFcAayWLFdt8FUFhj5mDP/abstract https://cassyni-user-files-prod.s3.amazonaws.com/8oB9izJGyZxY4T8o5c9uFt https://cassyni.com/events/UFFcAayWLFdt8FUFhj5mDP?videoPreview=1 Observing Open Access Weeknohttps://cassyni.com/events/UFFcAayWLFdt8FUFhj5mDP?videoPreview=12023-10-24T13:00:00+00:001685.24Topics at the heart of our communityIn recognition of International Open Access Week 2023, we will explore the transformative power and dynamic landscape of open access publishing. OA supports the greater visibility and impact of your work by ensuring reach to a broad and diverse global readership, transcending traditional barriers. OA is also a space where innovative formats and approaches are encouraged, which fosters creativity and experimentation in how research is communicated. Our presenters will showcase the depth and breadth of OA publishing at Springer Nature and how we are at the forefront driving open research and championing open science. https://cassyni-user-files-prod.s3.amazonaws.com/8oB9izJGyZxY4T8o5c9uFt https://cassyni.com/events/NpBCtKtWJwPqwMkpS2wHxh/abstract https://cassyni-user-files-prod.s3.amazonaws.com/GaXJYHNGeGTqThsheJ6eo8 https://cassyni.com/events/NpBCtKtWJwPqwMkpS2wHxh?videoPreview=1 Training Privacy: Privacy's Redefinition Through Artificial Intelligencenohttps://cassyni.com/events/NpBCtKtWJwPqwMkpS2wHxh?videoPreview=12024-02-06T22:00:00+00:005462.08SACLThe meaning of practical privacy comes from its lived experience in context. Privacy's meaning shifts as a function of transaction costs. What we thought of as civil liberties were often simply the experience of being left alone because it is too expensive to intrude into private life. The experience of surveillance capitalism -- the tracking of our data through our own devices and the data exhaust they produce, our clickstream, search, and location data -- is one example. But that is last decade's problem. The current problem of privacy is that neural nets, trained on human data, both exploit that data at the expense of people who fit similar data profiles, and reveal that data in peculiar ways when coaxed through appropriate prompts. This seminar explores the way in which the lived experience of privacy will shift in light of generative AI technologies.https://cassyni-user-files-prod.s3.amazonaws.com/GaXJYHNGeGTqThsheJ6eo8 https://cassyni.com/events/TG1eJUiEG4P6Q1WcLghs7B/seminar/qa https://cassyni.com/slides/outline/TG1eJUiEG4P6Q1WcLghs7B https://cassyni.com/events/TG1eJUiEG4P6Q1WcLghs7B/abstract https://cassyni-user-files-prod.s3.amazonaws.com/831W81DSGgwi9xWparrY3x https://cassyni.com/events/TG1eJUiEG4P6Q1WcLghs7B?videoPreview=1 Vortex-dominated flows: Can't live with them...Can't live without them...nohttps://cassyni.com/events/TG1eJUiEG4P6Q1WcLghs7B?videoPreview=12024-01-31T16:00:00+00:002813.08Department of AeronauticsVortex-dominated flows are in abundance in engineering applications and natural environment. Vortical structures influence not only the flow field but also have major implications on forces and moments experienced by objects as well as noise generated by them. If we are able to predict/infer the presence and characteristics of vortices, then we might be able to harness their potential to our benefit. In this talk, I will present experimental results from two case studies of work carried out in our lab where vortical structures lead to detrimental performance as well as improved efficiency. These examples come from varied application areas including flow past bluff bodies to underwater autonomous vehicles. https://cassyni-user-files-prod.s3.amazonaws.com/831W81DSGgwi9xWparrY3x https://cassyni.com/events/JNHXEv31Z6ZZGjUECAKQ5T/seminar/qa https://cassyni.com/slides/outline/JNHXEv31Z6ZZGjUECAKQ5T https://cassyni.com/events/JNHXEv31Z6ZZGjUECAKQ5T/abstract https://cassyni-user-files-prod.s3.amazonaws.com/43SncHHY3gFTZhYnMfi1MG https://cassyni.com/events/JNHXEv31Z6ZZGjUECAKQ5T?videoPreview=1 Where is home? War-displaced Ukrainians in New Zealandnohttps://cassyni.com/events/JNHXEv31Z6ZZGjUECAKQ5T?videoPreview=12023-10-06T03:10:00+00:003187.04Linguistics and Applied Language StudiesOn 24 February 2022, Russia's full-scale invasion of Ukraine began, and since then over 6 million Ukrainians have been registered as refugees globally (UNHCR, 2023). Last year, New Zealand opened the 2-year Special Ukraine Visa for displaced family members of New Zealand residents. Of those who arrived since on the visa, only half have remained, and the other half of visa holders have chosen instead to return to Ukraine early. This has prompted the current research which asks - why do some Ukrainians choose to return while some choose to remain in New Zealand? In this talk, I will share some of the results of this cross-disciplinary collaborative project that involves a longitudinal qualitative research process with displaced Ukrainians and their New Zealand family sponsors. The data, which include semi-structured interviews, linguistic identity portraits, participant photography, linguistic landscape interpretations, and neighbourhood walks together give insight into a complex journey of finding home and a place to belong.https://cassyni-user-files-prod.s3.amazonaws.com/43SncHHY3gFTZhYnMfi1MG https://cassyni.com/slides/outline/VEYpFxGZDAk2o1JFohZ62H https://cassyni.com/events/VEYpFxGZDAk2o1JFohZ62H/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Uoa4NnPwg98GJTJeAmL9Zg https://cassyni.com/events/VEYpFxGZDAk2o1JFohZ62H?videoPreview=1 Glass half full: Embracing the unexpected in granular systemsnohttps://cassyni.com/events/VEYpFxGZDAk2o1JFohZ62H?videoPreview=12020-10-22T12:00:00+00:003558.2Granular MatterGranular and multiphase systems containing solid particles display a host of behaviors unlike those of their single-phase counterparts. The unexpected behaviors are often at odds with current hypotheses, which ultimately leads to a greater physical understanding. In this talk, results from our investigations into liquid-coated particles, clustering instabilities, and cohesive-particle flows will be presented. Each topic will be discussed in chronological order, revealing the unexpected results we encountered, the hypotheses we developed to explain said behaviors, and the testing of these hypotheses until a a physical understanding emerged that we were confident in. This presentation echoes considerably the material covered in the 2020 van 't Hoff lecture (September 2020, TU Delft Process Technology Institute), with modifications to target the Granular Matter webinar audience.https://cassyni-user-files-prod.s3.amazonaws.com/Uoa4NnPwg98GJTJeAmL9Zg https://cassyni.com/slides/outline/52nCzTZqhjc8dKYQsvFnbw https://cassyni.com/events/52nCzTZqhjc8dKYQsvFnbw/abstract https://cassyni-user-files-prod.s3.amazonaws.com/GDeBcK47W8LM1ExJHVsje6 https://cassyni.com/events/52nCzTZqhjc8dKYQsvFnbw?videoPreview=1 Biases, Discrimination, and Fairness in Biometrics and Beyondnohttps://cassyni.com/events/52nCzTZqhjc8dKYQsvFnbw?videoPreview=12022-09-08T12:30:00+00:003764.4Journal on Image and Video ProcessingIn the last few years, we are witnessing a growing interest in the Artificial Intelligence research community in studying bias effects when machine learning methods are applied on large amounts of data. These bias effects can stem from the data itself or from the learning process, which nowadays is clearly dominated by deep learning methods that most of the time are quite opaque. When those learning processes are related to AI applications dealing with personal information, or whose application affects people’s lives, then biases can result in unfair AI-based automated decision-making processes, very harmful in terms of undesired discrimination among population groups. This keynote will discuss the current state of the topic with special emphasis in AI applications involving face biometrics. Recent methods and approaches to reduce undesired discrimination towards fair biometrics will be also discussed.https://cassyni-user-files-prod.s3.amazonaws.com/GDeBcK47W8LM1ExJHVsje6 https://cassyni.com/slides/outline/43Uzu6GnppVyxZiQmwnTo3 https://cassyni.com/events/43Uzu6GnppVyxZiQmwnTo3/abstract https://cassyni-user-files-prod.s3.amazonaws.com/HedfbqmzcWMQtxHfjHX2ES https://cassyni.com/events/43Uzu6GnppVyxZiQmwnTo3?videoPreview=1 Towards a Decentralized Geospatial Webnohttps://cassyni.com/events/43Uzu6GnppVyxZiQmwnTo3?videoPreview=12023-10-30T16:00:00+00:003751.32DeSci FoundationA large portion of the world’s data contains some type of geospatial information. This talk will provide an overview of projects and protocols to facilitate the creation, sharing, analysis, and storage of geospatial data via the decentralized web in an effort to make it more accessible, secure, and sustainable. Then, it will discuss the example of remotely-sensed satellite imagery, which is exploding in variety and volume and has many important applications across domains. Ongoing work to explore how the decentralized web can support these vital and increasingly large geospatial datasets will be highlighted and some potential pathways for the future will be considered. About the Speaker: Taylor is trained broadly as a geographic information scientist with interest in the full consumption lifecycle of geographic information from data creation, storage, dissemination, analysis, and decision-making. He obtained his PhD in Geographical Science from Arizona State University and is currently assistant professor at Department of Geographical Sciences at the University of Maryland, College Park and project lead at the EASIER data initiative. https://cassyni-user-files-prod.s3.amazonaws.com/HedfbqmzcWMQtxHfjHX2ES https://cassyni.com/slides/outline/ER6gsSrp3S8QV51Yo3jMUZ https://cassyni.com/events/ER6gsSrp3S8QV51Yo3jMUZ/abstract https://cassyni-user-files-prod.s3.amazonaws.com/2kbQjSRJ6eqqeYSnBjskU6 https://cassyni.com/events/ER6gsSrp3S8QV51Yo3jMUZ?videoPreview=1 Toeplitz operators and Bergman projections on weighted spaces of holomorphic functionsnohttps://cassyni.com/events/ER6gsSrp3S8QV51Yo3jMUZ?videoPreview=12023-06-01T15:00:00+00:003548.36Journal of Mathematical SciencesNo abstracthttps://cassyni-user-files-prod.s3.amazonaws.com/2kbQjSRJ6eqqeYSnBjskU6 https://cassyni.com/events/EukHv8WLUtgTUqYSPV29js/seminar/qa https://cassyni.com/slides/outline/EukHv8WLUtgTUqYSPV29js https://cassyni.com/events/EukHv8WLUtgTUqYSPV29js/abstract https://cassyni-user-files-prod.s3.amazonaws.com/2Q7eAZPyCyGCLN5pQEAe5k https://cassyni.com/events/EukHv8WLUtgTUqYSPV29js?videoPreview=1 ABI / DVC(Research) Hui 2023nohttps://cassyni.com/events/EukHv8WLUtgTUqYSPV29js?videoPreview=12023-10-03T03:00:00+00:003453.16The Auckland Bioengineering InstituteThis will be an opportunity to hear from Professor Frank Bloomfield, Ihorua (Rangahau) | Deputy Vice Chancellor (Research), on the sector level priorities emerging from Te Ara Paerangi Future Pathways, as well as an update on the strategic priorities in Taumata Teitei’s Research & Innovation portfolio. There will also be time for a Q&A and to hear from the wider researcher community. Attending with Frank will be Simon Holdaway (Associate Deputy Vice Chancellor Research) and Alex Thomas (Director – Research, Strategy & Delivery).https://cassyni-user-files-prod.s3.amazonaws.com/2Q7eAZPyCyGCLN5pQEAe5k https://cassyni.com/slides/outline/9UceQcPZerbP5yJCna2MkR https://cassyni.com/events/9UceQcPZerbP5yJCna2MkR/abstract https://cassyni-user-files-prod.s3.amazonaws.com/GTMuH7TPXuKp3TYvWuoXAE https://cassyni.com/events/9UceQcPZerbP5yJCna2MkR?videoPreview=1 Addressing employee-based race inequalities in the National Health Service (England): Accountability and the Workforce Race Equality Standardnohttps://cassyni.com/events/9UceQcPZerbP5yJCna2MkR?videoPreview=12023-11-16T22:00:00+00:004548.84SACLThis paper examines the efforts of the National Health Service (England) (NHSE) to address employee-based racial inequalities via the Workforce Race Equality Standard (WRES). The WRES mandates NHS-affiliated organisations including healthcare trusts to prepare annual reports detailing their performance against nine pre-established race-oriented indicators and planned actions to remedy identified inequities. Drawing on critical race theory (CRT), the study uses qualitative content analysis to analyse the WRES reports from 40 NHSE trusts between the period 2019 to 2021. Results indicate trust tendencies to present incomplete data or factual presentations with limited reflection of their race positions, and there is also evidence of practices of impression management. Regarding action plans, whilst there is evidence of some good practice, organisations do not seek to meaningfully capture and/or act on the lived experiences of colleagues, or disrupt institutional structures and systems that underlie discriminatory practices. Instead, actions often resort to generic NHSE or equality, diversity and inclusion initiatives or are grounded in the racial deficit model, and ignore intersectionality. Planned actions also sometimes show little progression over time or connection to the trust data. Overall, action plans may highlight practices of interest convergence: they espouse good intentions whilst, simultaneously, maintaining the status quo. Whilst the WRES is a laudable voluntary achievement, genuine change calls for a commitment to the cause – that is a felt accountability. https://cassyni-user-files-prod.s3.amazonaws.com/GTMuH7TPXuKp3TYvWuoXAE https://cassyni.com/slides/outline/KMcMSuqwqNbS5xzdahjAWy https://cassyni.com/events/KMcMSuqwqNbS5xzdahjAWy/abstract https://cassyni-user-files-prod.s3.amazonaws.com/FjY658KUrFRymv7KUsY8wG https://cassyni.com/events/KMcMSuqwqNbS5xzdahjAWy?videoPreview=1 Introducing Transformative Plant Biotechnology: Mycobiome-based improvement of growth and resilience in plantsnohttps://cassyni.com/events/KMcMSuqwqNbS5xzdahjAWy?videoPreview=12023-09-22T09:00:00+00:00859.56The New Phytologist FoundationThe application of biofertilizers is considered a viable biotechnological alternative to fuel future sustainable agriculture. In the past few years, an increasing number of research studies have been devoted to understanding the function of biological inoculum in agriculture productivity. Fungi are ubiquitously distributed as forms of symbiosis with most plants. The efficacy of these beneficial fungi on plant growth promotion has gained support from studies indicating their potential as biofertilizers and prospective agricultural applications. However, the theme of biological fertilizers based on fungal products is still underexplored, especially for the mechanisms of plant growth promotion. Here, we demonstrate a fungal isolate AR8 that displays a robust growth-promoting activity on the green leafy vegetable Choy Sum (Brassica rapa var. parachinensis). Colonization by AR8 initiates on the root surface and spreads systemically into the endosphere of Choy Sum with a biotrophic interaction. AR8 is involved in fungus-to-plant nutrient transfer through phosphorus solubilization and extra-radical hyphae transport to promote plant growth, which is generally assigned to mycorrhizal symbiosis. In terms of metabolomics, massive metabolic changes during plant growth upon AR8 inoculation further revealed the link between AR8 endophytic colonization and beneficial effects. Increased concentrations of energy-producing (sugars and amino acids) and adaptive (phenylpropanoids and glucosinolates) metabolites reflect the coordination of fungal interaction and plant growth promotion. Taken together, we uncover a novel beneficial fungus with vast potential as a biofertilizer and/or bio-stimulant for boosting plant biomass; and deciphered the metabolic basis of such mycobiome-based promotion of growth and yield in green leafy vegetable.https://cassyni-user-files-prod.s3.amazonaws.com/FjY658KUrFRymv7KUsY8wG https://cassyni.com/slides/outline/SmLR9AYpREuGaYX6Yaatvy https://cassyni.com/events/SmLR9AYpREuGaYX6Yaatvy/abstract https://cassyni-user-files-prod.s3.amazonaws.com/N5aAzXPZ2cCL46S2dw5fgr https://cassyni.com/events/SmLR9AYpREuGaYX6Yaatvy?videoPreview=1 On some computational challenges in numerical simulations of stably stratified flowsnohttps://cassyni.com/events/SmLR9AYpREuGaYX6Yaatvy?videoPreview=12021-06-21T12:00:00+00:005696.8Discover Applied SciencesThe stratified flows are common physical phenomena typically found in many environmental and industrial problems. Although being studied for many decades and centuries, new problems associated with their solution by means of high resolution numerical methods arise in simulations of related practical problems. The talk will focus on some issues found while solving the wall bounded stably stratified flows under a range of Froude and Reynolds numbers. The problems of choice of suitable numerical methods, computational setup and selection of soft boundary conditions on artificial boundaries will be discussed in detail. Selected results of stably stratified flow over a 3D hill will be presented to demonstrate the main points of the talk.https://cassyni-user-files-prod.s3.amazonaws.com/N5aAzXPZ2cCL46S2dw5fgr https://cassyni.com/slides/outline/24vCpzCaUMDKR6EN2MzoFK https://cassyni.com/events/24vCpzCaUMDKR6EN2MzoFK/abstract https://cassyni-user-files-prod.s3.amazonaws.com/3FhwVFsFBwaYTzNgkocB8i https://cassyni.com/events/24vCpzCaUMDKR6EN2MzoFK?videoPreview=1 Bifurcations and enumeration of central configurations of some planar restricted problemsnohttps://cassyni.com/events/24vCpzCaUMDKR6EN2MzoFK?videoPreview=12023-09-12T12:00:00+00:002066.8Celestial Mechanics and Dynamical AstronomyIn this work, we count (classes of) central configurations of the restricted and -body problems whose primaries form either a centered square or a centered equilateral triangle. More precisely, we count the central configurations formed by the centered polygons and a body of zero mass as the value of the mass of the central body varies. For this purpose, we study the bifurcation set. In addition, we classify the bifurcations as saddle-node bifurcations.https://cassyni-user-files-prod.s3.amazonaws.com/3FhwVFsFBwaYTzNgkocB8i https://cassyni.com/events/CSZWuyJV6KmU65DuL2t8ZT/seminar/qa https://cassyni.com/slides/outline/CSZWuyJV6KmU65DuL2t8ZT https://cassyni.com/events/CSZWuyJV6KmU65DuL2t8ZT/abstract https://cassyni-user-files-prod.s3.amazonaws.com/ALJsUwLETPGxUhakC3zmUi https://cassyni.com/events/CSZWuyJV6KmU65DuL2t8ZT?videoPreview=1 Ending Educational Inequities: Teachers Finding New and Creative Solutionsnohttps://cassyni.com/events/CSZWuyJV6KmU65DuL2t8ZT?videoPreview=12024-02-29T17:00:00+00:003182.04Lived Places Publishing**Julie Allan**, one of the authors of *Students, Teachers, Families, and a Socially Just Education: Rewriting the Grammar of Schooling to Unsettle Identities* (written with Francesca Peruzzo) will be in conversation with **Janise Hurtig**, Lived Places Publishing Collection Editor. They will discuss how the COVID-19 pandemic reinforced and exacerbated many of the inequalities in education, and led to a continuation of what sociologists have described as a ‘grammar of schooling’. This is an idea that describes features of education systems that persist throughout time, contexts, and cultures and includes the division of knowledge into separate subjects, rigid school timetables, the reproduction of particular forms of knowledge alongside the silencing of others, and exclusions and marginalisation from regular schooling. Yet, in their research with teachers, school leaders, and students in the US, UK, Australia, Chile, Malaysia, and Italy, Julie and Francesca uncovered many instances of teachers finding creative solutions to educational inequities and new ways to engage students in learning. Julie and Janise will discuss these innovations and explore the possibilities for these to become part of the new ‘normal’. https://cassyni-user-files-prod.s3.amazonaws.com/ALJsUwLETPGxUhakC3zmUi https://cassyni.com/slides/outline/NKXbqeEysUqnwbDvqbeVhP https://cassyni.com/events/NKXbqeEysUqnwbDvqbeVhP/abstract https://cassyni-user-files-prod.s3.amazonaws.com/QK2EEtK4JVnLEKLCBHgHfk https://cassyni.com/events/NKXbqeEysUqnwbDvqbeVhP?videoPreview=1 Radiatively heated thermal convection: bypassing the boundary layers to achieve the « ultimate » scaling regimenohttps://cassyni.com/events/NKXbqeEysUqnwbDvqbeVhP?videoPreview=12021-02-25T12:00:00+00:002649.56Leeds Institute for Fluid DynamicsThe heat flux transported by thermal convection has important implications for geophysical, astrophysical and industrial flows: one seeks a power-law relation between the convective heat flux and the internal temperature gradients. Decades of investigations of the Rayleigh-Bénard (RB) setup indicate that the heat transport is strongly restricted by boundary layers near the hot and cold solid plates. This prevents the observation of the “ultimate” scaling-regime of thermal convection, where bulk turbulence controls the convective heat flux independently of molecular viscosity and thermal diffusivity. In contrast with the RB setup, many geophysical and astrophysical convective flows are driven by radiation: absorption of incoming light by a body of fluid induces local heating. We have developed a laboratory experiment that reproduces such radiative heating: heat is input radiatively, directly inside the bulk turbulent flow and away from the boundary layers. We will provide experimental evidence that this naturally leads to the ultimate regime of thermal convection. These experimental results are confirmed quantitatively by Direct Numerical Simulations.https://cassyni-user-files-prod.s3.amazonaws.com/QK2EEtK4JVnLEKLCBHgHfk https://cassyni.com/slides/outline/7zj5VpUm9CnDdRU7RP7ZQy https://cassyni.com/events/7zj5VpUm9CnDdRU7RP7ZQy/abstract https://cassyni-user-files-prod.s3.amazonaws.com/CEtaMRqM8NUDn87ARiZkHc https://cassyni.com/events/7zj5VpUm9CnDdRU7RP7ZQy?videoPreview=1 Baculovirus entry into the central nervous system of Spodoptera exigua caterpillars is independent of the viral protein tyrosine phosphatasenohttps://cassyni.com/events/7zj5VpUm9CnDdRU7RP7ZQy?videoPreview=12024-02-13T22:20:00+00:002899.32Royal Society PublishingNeuroparasitism concerns the hostile take-over of a host’s nervous system by a foreign invader, in order to alter the behaviour of the host in favour of the parasite. One of the most remarkable cases of parasite-induced host behavioural manipulation comprises the changes baculoviruses induce in their caterpillar hosts. Baculoviruses may manipulate caterpillar behaviour in two ways: hyperactivity (increased movement in the horizontal plane) and/or tree-top disease (movement to elevated levels in the vertical plane). Those behavioural changes are followed by liquefaction and death of the caterpillar. In Autographa californica multiple nucleopolyhedrovirus (AcMNPV)-infected Spodoptera exigua caterpillars, an enzymatic active form of the virally-encoded protein tyrosine phosphatase (PTP) is needed for the expression of hyperactivity from 3 days post infection (dpi). Using eGFP-expressing recombinant AcMNPV strains we show that infection of the caterpillar’s central nervous system (CNS) can be observed primarily from 3 dpi onwards. In addition, we demonstrate that the structural and enzymatic function of PTP does not play a role in infection of the CNS. Instead we show that the virus entered the CNS via the trachea, progressing caudally to frontally through the CNS and that the infection progressed from the outermost cell layers towards the inner cell layers of the CNS, in a PTP independent manner. These findings help to further understand parasitic manipulation and the mechanisms by which neuroparasites infect the host nervous system to manipulate host behaviour. https://cassyni-user-files-prod.s3.amazonaws.com/CEtaMRqM8NUDn87ARiZkHc https://cassyni.com/events/2ZbRzJMzKAh9EZDspU7mRX/seminar/qa https://cassyni.com/slides/outline/2ZbRzJMzKAh9EZDspU7mRX https://cassyni.com/events/2ZbRzJMzKAh9EZDspU7mRX/abstract https://cassyni-user-files-prod.s3.amazonaws.com/TUiSTdTgpE8hjTnnVR5SMt https://cassyni.com/slides/outline/DRrj1LbXyEsckq3uS1MTNM https://cassyni.com/events/DRrj1LbXyEsckq3uS1MTNM/abstract https://cassyni-user-files-prod.s3.amazonaws.com/D3qycE4fmvxNV1py4XehXk https://cassyni.com/events/DRrj1LbXyEsckq3uS1MTNM?videoPreview=1 Investigation of common properties of 𝐿𝑖𝑝 and ℋ∞ functions (preliminary report)nohttps://cassyni.com/events/DRrj1LbXyEsckq3uS1MTNM?videoPreview=12023-02-23T15:00:00+00:003707.28Journal of Mathematical SciencesThis is an expository talk based on two continuing projects with José Bonet, Verónica Dimant, Luis Carlos García Lirola, and Manuel Maestre. Both studies center on spaces of Lipschitz functions and bounded holomorphic functions. For a metric space (𝑀, 𝑑) and a fixed point 𝑥0 ∈ 𝑀, let 𝐿𝑖𝑝𝑥0 (𝑀) ∶≡ {𝑓: 𝑀 → 𝕂 | 𝑓(𝑥0) = 0 and for some 𝐶 ≥ 0 |𝑓(𝑥) − 𝑓(𝑦)| ≤ 𝐶 𝑑(𝑥, 𝑦), ∀𝑥, 𝑦 ∈ 𝑀}. 𝐿𝑖𝑝𝑥0 (𝑀) is a Banach space with norm 𝐿(𝑓) ∶≡ inf { 𝐶 | the above inequality holds}. For a complex Banach space 𝑋 with open unit ball 𝐵𝑋, let 𝓗∞(𝐵𝑋) ∶≡ { 𝑓: 𝐵𝑋 → ℂ | 𝑓 is holomorphic and bounded}, which is a Banach space with the 𝑠𝑢𝑝 −norm. Although these spaces are quite different, they have a number of similarities which we investigate. For one thing, both 𝐿𝑖𝑝𝑥0 (𝑀) and 𝓗∞(𝐵𝑋) are dual spaces, and we look at characterizing norm attaining elements of the two spaces. We also describe our study of a “combination”' of these two types of spaces.https://cassyni-user-files-prod.s3.amazonaws.com/D3qycE4fmvxNV1py4XehXk https://cassyni.com/events/KrKCirXF5Z12j8SmaUgJc5/seminar/qa https://cassyni.com/slides/outline/KrKCirXF5Z12j8SmaUgJc5 https://cassyni.com/events/KrKCirXF5Z12j8SmaUgJc5/abstract https://cassyni-user-files-prod.s3.amazonaws.com/K7FhbA7mfXKFqVam1aiQQv https://cassyni.com/events/KrKCirXF5Z12j8SmaUgJc5?videoPreview=1 The scaling of the drag force on an accelerating platenohttps://cassyni.com/events/KrKCirXF5Z12j8SmaUgJc5?videoPreview=12024-05-03T15:00:00+00:003659.28Journal of Fluid MechanicsThe drag force on an accelerating object is usually described by a quasi-steady force that scales with the square of the instantaneous velocity and an added mass force due to the acceleration that scales directly proportional to the acceleration. This appears to underestimate the experimentally observed instantaneous drag force on an accelerating plate. We aim to find a better description of the drag force on a flat plate in an unsteady flow by measuring both the drag force and velocity field for a large range of constant accelerations and velocities. Our experiments show that the force due to acceleration scales with the square root of the acceleration, contrary to a linear scaling that is expected from added mass. This can be associated with a history force that describes the generation and advection of vorticity at the plate surface. We present a new scaling law for the drag force on accelerating plates. This avoids previous inconsistencies in using added mass forces in the description of forces on accelerating plates. This new scaling law has proven useful in predicting the drag force for different plate geometries and non-constant accelerations.https://cassyni-user-files-prod.s3.amazonaws.com/K7FhbA7mfXKFqVam1aiQQv https://cassyni.com/slides/outline/PJrS3e3v9ksfkpkLE94G8u https://cassyni.com/events/PJrS3e3v9ksfkpkLE94G8u/abstract https://cassyni-user-files-prod.s3.amazonaws.com/NbMh4iFQJsdpHSsCy9HEza https://cassyni.com/events/PJrS3e3v9ksfkpkLE94G8u?videoPreview=1 Supramolecular Chemistrynohttps://cassyni.com/events/PJrS3e3v9ksfkpkLE94G8u?videoPreview=12023-05-22T10:00:00+00:003857.28Thieme GroupSupramolecular chemistry has been explored cross-disciplinary as molecular sensors and machines, nano reactions, drug delivery, chemical catalysis and many more. It was in the spotlight in the past decades and the Nobel Prize was awarded to this research field in 1987.https://cassyni-user-files-prod.s3.amazonaws.com/NbMh4iFQJsdpHSsCy9HEza https://cassyni.com/events/WDvthD7GJAdTFdjubadCHb/seminar/qa https://cassyni.com/slides/outline/WDvthD7GJAdTFdjubadCHb https://cassyni.com/events/WDvthD7GJAdTFdjubadCHb/abstract https://cassyni-user-files-prod.s3.amazonaws.com/GSQDFEqJrmB3zX7ckncDv6 https://cassyni.com/events/WDvthD7GJAdTFdjubadCHb?videoPreview=1 Evolution and sustainability: gathering the strands for an Anthropocene synthesisnohttps://cassyni.com/events/WDvthD7GJAdTFdjubadCHb?videoPreview=12024-02-28T14:00:00+00:003731.2Royal Society PublishingHow did human societies evolve to become a major force of global change? What dynamics can lead societies on a trajectory of global sustainability? The astonishing growth in human population, economic activity, technological capacity and environmental impact - together known as the Anthropocene - has brought these questions to the fore. In this theme issue, we bring together the major elements of a theory of human evolution and sustainability on Earth. We show how diverse theories and approaches help to understand the past, present and future evolution of the Anthropocene, and discover new opportunities for moving towards sustainability. Collectively, the work provides the basis for an evolutionary synthesis of the human predicament on planet Earth.https://cassyni-user-files-prod.s3.amazonaws.com/GSQDFEqJrmB3zX7ckncDv6 https://cassyni.com/slides/outline/62AHRiQYnjVZ5wz4foKtsF https://cassyni.com/events/62AHRiQYnjVZ5wz4foKtsF/abstract https://cassyni-user-files-prod.s3.amazonaws.com/3BP77D7vtk3t8iqjJZtH6e https://cassyni.com/events/62AHRiQYnjVZ5wz4foKtsF?videoPreview=1 NHS Blood Transplant Risk Communication Toolsnohttps://cassyni.com/events/62AHRiQYnjVZ5wz4foKtsF?videoPreview=12022-02-02T15:00:00+00:001130.08Imperial College Renal and Transplant CentreNo abstracthttps://cassyni-user-files-prod.s3.amazonaws.com/3BP77D7vtk3t8iqjJZtH6e https://cassyni.com/events/WiaVjtknjdBWFQGoC1uzYu/seminar/qa https://cassyni.com/slides/outline/WiaVjtknjdBWFQGoC1uzYu https://cassyni.com/events/WiaVjtknjdBWFQGoC1uzYu/abstract https://cassyni-user-files-prod.s3.amazonaws.com/GSQk8MNs8apcrT5PkckAEa https://cassyni.com/events/WiaVjtknjdBWFQGoC1uzYu?videoPreview=1 PhD Celebration: A Sociolinguistic study of Language Documentation of the Denggan Language (Banam Bay Malekula, Vanuatu)nohttps://cassyni.com/events/WiaVjtknjdBWFQGoC1uzYu?videoPreview=12024-05-17T04:10:00+00:003083.04Linguistics and Applied Language StudiesIn the country of Vanuatu, there are estimated to be as many as 138 different languages. Of those, there are still many languages which remain undocumented. Yet, with the move to integrate the vernacular local languages into the education system, speakers of these languages are developing orthography systems as a way of maintaining the vitality of their language in oral and written forms. My thesis is a result of a community orthography and language documentation project in Southeast Malekula, Vanuatu. It focuses on the language, Denggan, formerly known as Banam Bay Language or Burmbar (ISO code vrt-639-3) spoken by around 900-1000 speakers. This seminar unpacks the language project that was at the centre of this thesis work, as well as the different directions my thesis took along the way. This includes examining what collaboration means when working within a community project in Vanuatu. I will present on my exploration of relevant Indigenous Pacific epistemologies and how the navigation between these epistemologies and Western academic traditions impacted my research journey. I will give an overview of the language documentation findings and the contributions of the first Denggan grammar sketch. I will also report on reflections around community collaborations and how I navigated the responsibilities between my commitments to the community and finishing my degree. https://cassyni-user-files-prod.s3.amazonaws.com/GSQk8MNs8apcrT5PkckAEa https://cassyni.com/events/3YvGCJAvbSj23nkHD1XXs3/seminar/qa https://cassyni.com/slides/outline/3YvGCJAvbSj23nkHD1XXs3 https://cassyni.com/events/3YvGCJAvbSj23nkHD1XXs3/abstract https://cassyni-user-files-prod.s3.amazonaws.com/V5oDmuRPDpszkntQh3SogA https://cassyni.com/events/3YvGCJAvbSj23nkHD1XXs3?videoPreview=1 🚀 AfriMed-QA Project Launchnohttps://cassyni.com/events/3YvGCJAvbSj23nkHD1XXs3?videoPreview=12024-03-14T15:00:00+00:006797.92SisonkeBiotikThe AfriMed-QA Project aims to benchmark large language models (LLMs) on African medical school exam questions for fairness and performance. The project will be carried out in 3 phases 1) Dataset creation * Funded dataset creation ($30000 raised so far) * Volunteer dataset creation via invitations to medical schools for participation 2) AI model benchmarking 3) Academic outputs and paper writinghttps://cassyni-user-files-prod.s3.amazonaws.com/V5oDmuRPDpszkntQh3SogA https://cassyni.com/slides/outline/Fu8NMPM3ZtZswTz6BN6G1B https://cassyni.com/events/Fu8NMPM3ZtZswTz6BN6G1B/abstract https://cassyni-user-files-prod.s3.amazonaws.com/YP1oksV8obzBbxJkfH6dbL https://cassyni.com/events/Fu8NMPM3ZtZswTz6BN6G1B?videoPreview=1 Data-driven Reduced Order Models for Multi-scale, Multi-physics Systemsnohttps://cassyni.com/events/Fu8NMPM3ZtZswTz6BN6G1B?videoPreview=12021-10-06T10:00:00+00:003524.68Data-Centric Engineering JournalThis talk presents advances towards the development of effective reduced order models (ROMs) for complex multi-scale multi-physics problems. As a representative application, we consider combustion dynamics in a rocket engine, which is characterized by the coupling between heat release, hydrodynamics and acoustics. The first part of the talk is focused on improving robustness and consistency: A structure-preserving transformation of the state variables is used along with a discretely consistent least squares formulation to yield symmetrized model operators in both explicit and implicit time integration settings. The resulting reduced order model is well-conditioned and globally stable. Local stability is promoted via limiters that enforce physical realizability. The second part of the talk is focused on improving accuracy: Dimension reduction approaches based on static linear manifolds are not effective in addressing multi-scale problems with significant convection. To help mitigate this issue, we present formulations using adaptive spaces. Opportunities for further improvement are also highlighted. The last part of the talk discusses tractability : ROMs are used to enable computations of problems for which full order models are not affordable. In particular, we develop a multi-fidelity framework in which component-level ROMs are trained on small domains, and integrated to enable full-system predictions in an affordable manner. In essence, geometry-specific training is replaced by the response generated by perturbing the characteristics at the boundary of the truncated domain. This training method is shown to enhance predictive capabilities and robustness of the resulting ROMs, including conditions outside the training range. https://cassyni-user-files-prod.s3.amazonaws.com/YP1oksV8obzBbxJkfH6dbL https://cassyni.com/slides/outline/ATziqsEGjrUoYbjraT6U1j https://cassyni.com/events/ATziqsEGjrUoYbjraT6U1j/abstract https://cassyni-user-files-prod.s3.amazonaws.com/DeHV3spFt2FQAwatYFCsiN https://cassyni.com/events/ATziqsEGjrUoYbjraT6U1j?videoPreview=1 Existence of solutions for superquadratic or asymptotically quadratic fractional Hamiltonian systemsnohttps://cassyni.com/events/ATziqsEGjrUoYbjraT6U1j?videoPreview=12024-04-05T12:00:00+00:002585.04Partial Differential Equations and ApplicationsWe are concerned with a class of periodic fractional Hamiltonian systems when the Hamiltonian is superquadratic not satisfying the well-known Ambrosetti-Rabinowitz condition or with asymptotically quadratic growth. Using the monotonicity trick of Jeanjean and the concentration compactness principle, we prove the existence of nontrivial solution.https://cassyni-user-files-prod.s3.amazonaws.com/DeHV3spFt2FQAwatYFCsiN https://cassyni.com/slides/outline/AxeKtYsoBK2rYNGkAtPGH3 https://cassyni.com/events/AxeKtYsoBK2rYNGkAtPGH3/abstract https://cassyni-user-files-prod.s3.amazonaws.com/CcNn8wZzTTtJ2s5VosT9CJ https://cassyni.com/events/AxeKtYsoBK2rYNGkAtPGH3?videoPreview=1 Unveiling the submerged secrets: bumblebee queens' resilience to floodingnohttps://cassyni.com/events/AxeKtYsoBK2rYNGkAtPGH3?videoPreview=12024-04-15T12:00:00+00:00806.0Royal Society PublishingIn a previous study, an experimental oversight led to the accumulation of water filling a container housing diapausing bumblebee queens. Surprisingly, after draining the water, queens were found to be alive. This observation raises a compelling question: can bumblebee queens endure periods of inundation while overwintering underground? To address this question, we conducted an experiment using 143 common eastern bumblebee (Bombus impatiens) queens placed in soil-filled tubes and subjected to artificially-induced diapause in a refrigerated unit for seven days. Tap water was then added to the tubes and queens (n=21/treatment) were either maintained underwater using a plunger-like apparatus or left to float naturally on the water’s surface for varying durations (8h, 24h, or 7 days) while remaining in overwintering conditions. Seventeen queens served as controls. After the submersion period, queens were removed from water, transferred to new tubes with soil, and kept in cold storage for 8 weeks. Overall queen survival remained consistently high (89.5 ± 6.4%) across all treatments and did not differ among submersion regimes and durations. These results demonstrate the remarkable ability of diapausing B. impatiens queens to withstand submersion underwater for up to one week, indicating their adaptations to survive periods of flooding in the wild.https://cassyni-user-files-prod.s3.amazonaws.com/CcNn8wZzTTtJ2s5VosT9CJ https://cassyni.com/events/MLjbocDtF4QdYgps5ogLTw/seminar/qa https://cassyni.com/slides/outline/MLjbocDtF4QdYgps5ogLTw https://cassyni.com/events/MLjbocDtF4QdYgps5ogLTw/abstract https://cassyni-user-files-prod.s3.amazonaws.com/ELePoLLKzZpdtKcPbFaz6r https://cassyni.com/events/MLjbocDtF4QdYgps5ogLTw?videoPreview=1 Simulating Liver Resections to Predict Hepatic Perfusion Alterationsnohttps://cassyni.com/events/MLjbocDtF4QdYgps5ogLTw?videoPreview=12024-04-17T14:00:00+00:003452.4Royal Society PublishingPartial liver resections are routinely performed in living donor liver transplantation and to debulk tumours in liver malignancies, but surgical decisions on vessel reconstruction for adequate inflow and outflow are challenging. Pre-operative evaluation is often limited to radiological imaging, which fails to account for post-resection haemodynamic alterations. Substantial evidence suggests post-surgical increase in local volume flow rate enhances shear stress, signalling hepatic regeneration, but excessive shear stress has been postulated to result in small for size syndrome and liver failure. Predicting haemodynamic alterations throughout the liver is particularly challenging due to the dendritic architecture of the vasculature, spanning several orders of magnitude in diameter. Therefore, we developed a mathematical lumped parameter model with realistic heterogeneities capturing inflow/outflow of the human liver to simulate acute perfusion alterations following surgical resection. Our model is parametrized using clinical measurements, relies on a single free parameter and accurately captures established perfusion characteristics. We quantify acute changes in volume flow rate, flow speed and wall shear stress following variable, realistic liver resections and make comparisons with the intact liver. Our numerical model runs in minutes and can be adapted to patient-specific anatomy, providing a novel computational tool aimed at assisting pre- and intra-operative surgical decisions for liver resections.https://cassyni-user-files-prod.s3.amazonaws.com/ELePoLLKzZpdtKcPbFaz6r https://cassyni.com/events/HtCNUphDArXzWzXJS9JNw7/seminar/qa https://cassyni.com/slides/outline/HtCNUphDArXzWzXJS9JNw7 https://cassyni.com/events/HtCNUphDArXzWzXJS9JNw7/abstract https://cassyni-user-files-prod.s3.amazonaws.com/9ZNg9WjAvmjgY3jKCC92rJ https://cassyni.com/events/HtCNUphDArXzWzXJS9JNw7?videoPreview=1 Experimental studies of cardiovascular assist device and coronary artery model with mock circulatory loopnohttps://cassyni.com/events/HtCNUphDArXzWzXJS9JNw7?videoPreview=12024-07-16T14:00:00+00:003646.44Experiments in FluidsThe mock circulatory loop (MCL) is an in vitro experimental system that can provide continuous pulsatile flows and simulate different physiological or pathological parameters of the human circulation system. With MCL, experimental studies can be conducted to investigate clinical problems in vitro. Cardiovascular diseases associated with coronary artery are the most significant issues causing human deaths. The coronary artery bypass grafting (CABG) is a surgery procedure for treating the coronary artery disease. Therefore, silicone models of coronary artery and graft anastomosis with a 45-degree end-to-side structure are connected in the circulation of MCL system. Simulated boold flows can be in vitro studied for understanding the causes of coronary artery diseases and graft failure in the aspect of hemodynamics. Moreover, percutaneous ventricular assist device (pVAD) is an effective method to treat heart failure, but its complications, mainly including hemolysis and thrombus formation, cannot be ignored. Hydraulic performance and hemolysis experiments are essential to guide the development of pVAD. The experiments on testing thrombus location can help reducing the incidence of complications. https://cassyni-user-files-prod.s3.amazonaws.com/9ZNg9WjAvmjgY3jKCC92rJ https://cassyni.com/slides/outline/TmATQVdhx1cKNWXKwi4k53 https://cassyni.com/events/TmATQVdhx1cKNWXKwi4k53/abstract https://cassyni-user-files-prod.s3.amazonaws.com/TJPnu8J8pdFBrnbh8R2soc https://cassyni.com/events/TmATQVdhx1cKNWXKwi4k53?videoPreview=1 AI/ML+Physics Part 5: Employing an Optimization Algorithmnohttps://cassyni.com/events/TmATQVdhx1cKNWXKwi4k53?videoPreview=12024-04-05T11:00:00+00:001954.52Brunton LabThis video discusses the fifth stage of the machine learning process: (5) selecting and implementing an optimization algorithm to train the model. There are opportunities to incorporate physics into this stage of the process, such as using constrained optimization to force a model onto a susbpace or submanifold characterized by a symmetry or other physical constraint. SLB acknowledges support from the National Science Foundation AI Institute in Dynamic Systems and from The Boeing Company.https://cassyni-user-files-prod.s3.amazonaws.com/TJPnu8J8pdFBrnbh8R2soc https://cassyni.com/events/aoRxGLtgkFyqepp4g9cC5/seminar/qa https://cassyni.com/slides/outline/aoRxGLtgkFyqepp4g9cC5 https://cassyni.com/events/aoRxGLtgkFyqepp4g9cC5/abstract https://cassyni-user-files-prod.s3.amazonaws.com/LUtGU8fNQup8LJnXigSFHG https://cassyni.com/events/aoRxGLtgkFyqepp4g9cC5?videoPreview=1 Convective heat transfer and reacting flowsnohttps://cassyni.com/events/aoRxGLtgkFyqepp4g9cC5?videoPreview=12024-06-12T14:30:00+00:005578.44Nektar++ Development TeamThis session focuses on the applications that involves heat transfer and comprises the following talks 1. Radially heated Taylor-Couette flow in Nektar++ 2. Flow structures arising from the interplay between shear and buoyancy 3. NESO - A Nektar++-based framework for fusion plasma physicshttps://cassyni-user-files-prod.s3.amazonaws.com/LUtGU8fNQup8LJnXigSFHG https://cassyni.com/slides/outline/Dw1Y7MX1fC6qjL4d32iLLD https://cassyni.com/events/Dw1Y7MX1fC6qjL4d32iLLD/abstract https://cassyni-user-files-prod.s3.amazonaws.com/4mg8UPto54aHJ3qrbK8PHp https://cassyni.com/events/Dw1Y7MX1fC6qjL4d32iLLD?videoPreview=1 Finite-Horizon, Energy-Optimal Trajectories in Unsteady Flowsnohttps://cassyni.com/events/Dw1Y7MX1fC6qjL4d32iLLD?videoPreview=12021-05-01T14:00:00+00:001146.12Brunton LabIntelligent mobile sensors, such as uninhabited aerial or underwater vehicles, are becoming prevalent in environmental sensing and monitoring applications. These active sensing platforms operate in unsteady fluid flows, including windy urban environments, hurricanes, and ocean currents. Often constrained in their actuation capabilities, the dynamics of these mobile sensors depend strongly on the background flow, making their deployment and control particularly challenging. Therefore, efficient trajectory planning with partial knowledge about the background flow is essential for teams of mobile sensors to adaptively sense and monitor their environments. In this work, we investigate the use of finite-horizon model predictive control (MPC) for the energy-efficient trajectory planning of an active mobile sensor in an unsteady fluid flow field. We uncover connections between the finite-time optimal trajectories and finite-time Lyapunov exponents (FTLE) of the background flow, confirming that energy-efficient trajectories exploit invariant coherent structures in the flow. We demonstrate our findings on the unsteady double gyre vector field, which is a canonical model for chaotic mixing in the ocean. We present an exhaustive search through critical MPC parameters including the prediction horizon, maximum sensor actuation, and relative penalty on the accumulated state error and actuation effort. We find that even relatively short prediction horizons can often yield nearly energy-optimal trajectories. These results are promising for the adaptive planning of energy-efficient trajectories for swarms of mobile sensors in distributed sensing and monitoring.https://cassyni-user-files-prod.s3.amazonaws.com/4mg8UPto54aHJ3qrbK8PHp https://cassyni.com/events/EvLNKMKwwU8iYZb2Ra86mj/abstract https://cassyni-user-files-prod.s3.amazonaws.com/LnvN3jv4DkdirvGM8PeBPt https://cassyni.com/slides/outline/GQFZLmkdrUsL6GYBaicy49 https://cassyni.com/events/GQFZLmkdrUsL6GYBaicy49/abstract https://cassyni-user-files-prod.s3.amazonaws.com/YWeUwvqg6saUpNUAMrBBdp https://cassyni.com/events/GQFZLmkdrUsL6GYBaicy49?videoPreview=1 Enabling Model Reduction of Meshless Nonlocal Methods via Modal Reference Spacesnohttps://cassyni.com/events/GQFZLmkdrUsL6GYBaicy49?videoPreview=12024-04-18T14:00:00+00:003264.28AI Institute in Dynamic SystemsNo abstracthttps://cassyni-user-files-prod.s3.amazonaws.com/YWeUwvqg6saUpNUAMrBBdp https://cassyni.com/slides/outline/8zXVeX3mGcZpLEMH2Z1Lc5 https://cassyni.com/events/8zXVeX3mGcZpLEMH2Z1Lc5/abstract https://cassyni-user-files-prod.s3.amazonaws.com/T5WqSQiuGqVMkHThqqHfN6 https://cassyni.com/events/8zXVeX3mGcZpLEMH2Z1Lc5?videoPreview=1 Incorporating physics and decision making into deep learning via implicit layersnohttps://cassyni.com/events/8zXVeX3mGcZpLEMH2Z1Lc5?videoPreview=12021-01-22T14:00:00+00:004726.56AI Institute in Dynamic SystemsDespite their wide applicability, deep networks often fail to exactly capture simple 'known' features of real-world data sets, such as those governed by physical laws. In this talk, I'll present methods for integrating hard constraints, such as those associated with decision making, optimization problems, or physical simulation, directly into the predictions of a deep network. Our tool for achieving this will be the use of so-called implicit layers in deep models: layers that are defined implicitly in terms of conditions we would like them to satisfy, rather than via an explicit computation graph. I'll discuss how we can use these layers to embed (exact) physical constraints, robust control criteria, and task-based objectives, all within the framework of traditional deep learning. I will highlight several applications of this work in reinforcement learning, control, energy systems, and other settings, and discuss generalizations and directions for future work in the area.https://cassyni-user-files-prod.s3.amazonaws.com/T5WqSQiuGqVMkHThqqHfN6 https://cassyni.com/slides/outline/BTmWswHPTuLJhApqaEuyL1 https://cassyni.com/events/BTmWswHPTuLJhApqaEuyL1/abstract https://cassyni-user-files-prod.s3.amazonaws.com/7q5nxZozArdd2ttUyqYTgA https://cassyni.com/events/BTmWswHPTuLJhApqaEuyL1?videoPreview=1 The role of clonal reproduction in shaping DNA methylation patterns across angiospermsnohttps://cassyni.com/events/BTmWswHPTuLJhApqaEuyL1?videoPreview=12024-06-06T20:35:00+00:00882.16New Phytologist Foundation Clonal reproduction is broadly prevalent across angiosperms and has long been associated with the accumulation of deleterious mutations. However, the impacts of clonal reproduction on epigenetic modifications remain relatively unknown. DNA methylation is a common reversible epigenetic modification to DNA that can have an impact on gene expression and phenotype in plants. Here, we investigated DNA methylation patterns using publicly available methylome data for 45 angiosperm species. We found that clonal plants propagated through stem-based clonal growth forms had lower DNA methylation than strictly sexual plant species in all three contexts (CG, CHG, and CHH, where H = A, C, or T). It is possible that lower DNA methylation levels in clonal plants could impact their genome evolution by reducing cytosine deamination and/or increasing transposon movement. We also explored how transitions to clonal reproduction across angiosperms have influenced the rate of DNA methylation evolution. Currently, we are generating DNA methylation sequencing data in 34 wild angiosperm species to better understand how domestication and diverse clonal growth forms impact DNA methylation levels across a broader dataset. This study sheds light on how clonal propagation influences the evolution of plant methylomes, which has important implications for plant genome evolution.https://cassyni-user-files-prod.s3.amazonaws.com/7q5nxZozArdd2ttUyqYTgA https://cassyni.com/slides/outline/Pp1F9eyPqi6tjKm3qAR96m https://cassyni.com/events/Pp1F9eyPqi6tjKm3qAR96m/abstract https://cassyni-user-files-prod.s3.amazonaws.com/H6EsaPC5QC1TPRAqXfhLPQ https://cassyni.com/events/Pp1F9eyPqi6tjKm3qAR96m?videoPreview=1 Genetics and Evolutionary Mechanisms of a balanced flower color polymorphism in Whipple’s Penstemonnohttps://cassyni.com/events/Pp1F9eyPqi6tjKm3qAR96m?videoPreview=12024-06-08T17:45:00+00:00917.12New Phytologist Foundation Diversity in populations is shaped by the interplay of selective pressures and the genetic basis of phenotypes. Purifying or directional selection tends to favor a single optimal phenotype, leading to a reduction in genetic diversity over time. In contrast, balancing selection employs various mechanisms to maintain genetic diversity. The perennial wildflower Penstemon whippleanus exhibits within-population flower color polymorphism (FCP) across a wide geographic range in the Rocky Mountains, suggesting balancing selection is preserving genetic diversity. Here we examine the genetic basis and sources of selection acting on the flower color polymorphism in P. whippleanus . Using Illumina resequencing of 73 individuals across 10 populations, we identified the genetic basis for FCP as a MYB transcription factor regulating anthocyanin pigment biosynthesis. The alleles that underlie the FCP are shared across polymorphic populations, indicating the remarkable persistence of genetic variation across geographically widespread populations. This finding contrasts with scenarios where purifying or directional selection may result in multiple genetic origins for the same trait, acting on more recent timescales. Tests of molecular evolution suggest the nature of selection acting on the allelic variation. Finally, preliminary pollinator observations in natural polymorphic populations do not immediately identify the source of balancing selection.https://cassyni-user-files-prod.s3.amazonaws.com/H6EsaPC5QC1TPRAqXfhLPQ https://cassyni.com/slides/outline/RnbfLPZVbYKeq33HC8H5XK https://cassyni.com/events/RnbfLPZVbYKeq33HC8H5XK/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Pdtqsat4qJtCnegKMRixBx https://cassyni.com/events/RnbfLPZVbYKeq33HC8H5XK?videoPreview=1 Trust, Power, and Psychological Safetynohttps://cassyni.com/events/RnbfLPZVbYKeq33HC8H5XK?videoPreview=12024-12-12T21:00:00+00:003697.52Family MedicineObjectives: At the conclusion of this session, attendees will be able to: - Describe frameworks to facilitate psychological safety and authentic engagement with power differentials - Define the components of trauma and trust - Promote trauma informed and mitigative practiceshttps://cassyni-user-files-prod.s3.amazonaws.com/Pdtqsat4qJtCnegKMRixBx https://cassyni.com/events/UFqgZoo7nq69ByWqjpBiFF/seminar/qa https://cassyni.com/slides/outline/UFqgZoo7nq69ByWqjpBiFF https://cassyni.com/events/UFqgZoo7nq69ByWqjpBiFF/abstract https://cassyni-user-files-prod.s3.amazonaws.com/9ohUfrYw9W1jNYNsSxjJ86 https://cassyni.com/events/UFqgZoo7nq69ByWqjpBiFF?videoPreview=1 Copper and Iron Make the Difference: Developing Sustainable Photoredox Catalyzed Transformationsnohttps://cassyni.com/events/UFqgZoo7nq69ByWqjpBiFF?videoPreview=12024-07-22T10:00:00+00:003136.84Tetrahedron Chem and Tetrahedron Green ChemSynthetic organic chemistry undertakes significant efforts to develop new catalytic transformations that utilize greener reagents and avoid stoichiometric additives. In this regard, visible-light photoredox catalysis offers a unique activation mode of molecules, which serves as an alternative to many thermal transition-metals catalyzed reactions. Most photoredox-catalyzed processes capitalize on heavy metals, namely, Ru(II) or Ir(III)-complexes, which can serve as single electron oxidants or reductants in their photoexcited states. Copper-and iron-based photo¬catalysts are rapidly emerging, offering economic and ecologic advantages but, in addition, can interact with substrates beyond electron transfer via inner sphere mechanisms, which have been successfully utilized to achieve challenging transformations. Emphasizing the principles of photoredox catalysis, selected synthetic applications from our laboratory will be discussed, highlighting the opportunities copper- and iron-photocatalysts offer in this area. https://cassyni-user-files-prod.s3.amazonaws.com/9ohUfrYw9W1jNYNsSxjJ86 https://cassyni.com/slides/outline/7WcJd6d5Mbpt3z4ZThGNMj https://cassyni.com/events/7WcJd6d5Mbpt3z4ZThGNMj/abstract https://cassyni-user-files-prod.s3.amazonaws.com/2ExzDRrXyftHHrNhRQhnvS https://cassyni.com/events/7WcJd6d5Mbpt3z4ZThGNMj?videoPreview=1 PCAN Podcast Episode 7: DKN-01 as monotherapy or in combination with docetaxelnohttps://cassyni.com/events/7WcJd6d5Mbpt3z4ZThGNMj?videoPreview=12024-06-14T14:00:00+00:001426.24Research Seminars by Springer NatureNo abstracthttps://cassyni-user-files-prod.s3.amazonaws.com/2ExzDRrXyftHHrNhRQhnvS https://cassyni.com/events/MqST5YuBVEpEBrH15adUZ3/abstract https://cassyni-user-files-prod.s3.amazonaws.com/3UPYWtZ5ZgM3PtRMJySGVc https://cassyni.com/events/QJgUJy8ogXaiYnkZdGY7Gy/seminar/qa https://cassyni.com/slides/outline/QJgUJy8ogXaiYnkZdGY7Gy https://cassyni.com/events/QJgUJy8ogXaiYnkZdGY7Gy/abstract https://cassyni-user-files-prod.s3.amazonaws.com/TJCieF885S59vwz6P5fsJE https://cassyni.com/events/QJgUJy8ogXaiYnkZdGY7Gy?videoPreview=1 Education and engagementnohttps://cassyni.com/events/QJgUJy8ogXaiYnkZdGY7Gy?videoPreview=12024-10-08T11:05:00+00:001137.2North West London Kidney CareNo abstracthttps://cassyni-user-files-prod.s3.amazonaws.com/TJCieF885S59vwz6P5fsJE https://cassyni.com/slides/outline/KNCRr8fZHx3h9h3Dcnq7Yq https://cassyni.com/events/KNCRr8fZHx3h9h3Dcnq7Yq/abstract https://cassyni-user-files-prod.s3.amazonaws.com/TXhqTNeZemQDJZjYXKQsiN https://cassyni.com/events/KNCRr8fZHx3h9h3Dcnq7Yq?videoPreview=1 Prediction of major gastro-intestinal bleeding events in haemodialysisnohttps://cassyni.com/events/KNCRr8fZHx3h9h3Dcnq7Yq?videoPreview=12024-08-21T12:45:00+00:00898.0NoneNo abstracthttps://cassyni-user-files-prod.s3.amazonaws.com/TXhqTNeZemQDJZjYXKQsiN https://cassyni.com/slides/outline/5Y3WYzYs18YDWWaWi7Uhp1 https://cassyni.com/events/5Y3WYzYs18YDWWaWi7Uhp1/abstract https://cassyni-user-files-prod.s3.amazonaws.com/H1eQF4KhAUKuWBTwoKt9hQ https://cassyni.com/events/5Y3WYzYs18YDWWaWi7Uhp1?videoPreview=1 Large-scale genome-wide analysis links lactic acid bacteria from food with the gut microbiomenohttps://cassyni.com/events/5Y3WYzYs18YDWWaWi7Uhp1?videoPreview=12021-11-09T17:00:00+00:0067.96Microbiome Virtual International Forum Lactic acid bacteria (LAB) are fundamental in the production of fermented foods and several strains are regarded as probiotics. Large quantities of live LAB are consumed within fermented foods, but it is not yet known to what extent the LAB we ingest become members of the gut microbiome. By analysis of 9445 metagenomes from human samples, we demonstrate that the prevalence and abundance of LAB species in stool samples is generally low and linked to age, lifestyle, and geography, with Streptococcus thermophilus and Lactococcus lactis being most prevalent. Moreover, we identify genome-based differences between food and gut microbes by considering 666 metagenome-assembled genomes (MAGs) newly reconstructed from fermented food microbiomes along with 154,723 human MAGs and 193,078 reference genomes. Our large-scale genome-wide analysis demonstrates that closely related LAB strains occur in both food and gut environments and provides unprecedented evidence that fermented foods can be indeed regarded as a possible source of LAB for the gut microbiome. link to the OA-paper https://doi.org/10.1038/s41467-020-16438-8https://cassyni-user-files-prod.s3.amazonaws.com/H1eQF4KhAUKuWBTwoKt9hQ https://cassyni.com/slides/outline/SHGtVhiuSMoUeW2nzEQ3hX https://cassyni.com/events/SHGtVhiuSMoUeW2nzEQ3hX/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Cmb6wxS5nFLN5gumRHiBft https://cassyni.com/events/SHGtVhiuSMoUeW2nzEQ3hX?videoPreview=1 1D drift-kinetic numerical model based on semi-implicit particle-in-cell methodnohttps://cassyni.com/events/SHGtVhiuSMoUeW2nzEQ3hX?videoPreview=12024-09-12T12:00:00+00:001283.12Computer Physics CommunicationsWe present a new one-dimensional drift-kinetic electrostatic model based on the particle-in-cell method and capable of simulating the processes of plasma heating and confinement in mirror traps. The most of particle and energy losses in these traps occur along the magnetic field lines. The key role in limiting these losses is played by the ambipolar electric potential which creates a potential barrier for electrons and significantly reduces the heat flux that, without this barrier, would go to wall due to the classical electron thermal conductivity. However, modeling the formation of such a potential on real spatial and temporal scales of experiments is a challenging problem, since it requires a detailed description of not only ion, but also electron kinetics. In this work, we propose to solve the problem of taking into account electron kinetic effects on the time scale of plasma confinement in a mirror trap using the particle-in-cell method adapted to the approximate drift-kinetic equations of plasma motion. Unlike other electrostatic particle-in-cell models, which use fully implicit schemes to solve the nonlinear system of Vlasov-Poisson and Vlasov-Ampere equations, we propose a semi-implicit approach. By analogy with the Energy Conserving Semi-Implicit Method (ECSIM), it allows for precise conservation of energy and reduces the procedure for finding the electric field to inverting a tridiagonal matrix without multiple nonlinear iterations. Such a model will be useful for simulating not only collisional losses of hot plasma in fusion experiments, but also for studying the features of creating cold starting plasma in mirror traps using plasma or electron guns.https://cassyni-user-files-prod.s3.amazonaws.com/Cmb6wxS5nFLN5gumRHiBft https://cassyni.com/slides/outline/SmvVYPNRspMXeGZgafgqxq https://cassyni.com/events/SmvVYPNRspMXeGZgafgqxq/abstract https://cassyni-user-files-prod.s3.amazonaws.com/NCTFEEchmn8yjmpr4aBQhL https://cassyni.com/events/SmvVYPNRspMXeGZgafgqxq?videoPreview=1 MVIF.1 Open-access paper highlightsnohttps://cassyni.com/events/SmvVYPNRspMXeGZgafgqxq?videoPreview=12021-09-14T15:00:00+00:00434.04Microbiome Virtual International ForumHuman gut bacterial strains can co-exist with their hosts for decades, but little is known about how these microbes persist and disperse, and evolve thereby. Here, we examined these processes in 5,278 adult and infant fecal metagenomes, longitudinally sampled in individuals and families. Our analyses revealed that a subset of gut species is extremely persistent in individuals, families, and geographic regions, represented often by locally successful strains of the phylum Bacteroidota. These “tenacious” bacteria show high levels of genetic adaptation to the human host but a high probability of loss upon antibiotic interventions. By contrast, heredipersistent bacteria, notably Firmicutes, often rely on dispersal strategies with weak phylogeographic patterns but strong family transmissions, likely related to sporulation. These analyses describe how different dispersal strategies can lead to the long-term persistence of human gut microbes with implications for gut flora modulations. **Motivation** Metatranscriptomics (MTX) has become an increasingly practical way to profile the functional activity of microbial communities in situ. However, MTX remains underutilized due to experimental and computational limitations. The latter are complicated by non-independent changes in both RNA transcript levels and their underlying genomic DNA copies (as microbes simultaneously change their overall abundance in the population and regulate individual transcripts), genetic plasticity (as whole loci are frequently gained and lost in microbial lineages) and measurement compositionality and zero-inflation. Here, we present a systematic evaluation of and recommendations for differential expression (DE) analysis in MTX. **Results** We designed and assessed six statistical models for DE discovery in MTX that incorporate different combinations of DNA and RNA normalization and assumptions about the underlying changes of gene copies or species abundance within communities. We evaluated these models on multiple simulated and real multi-omic datasets. Models adjusting transcripts relative to their encoding gene copies as a covariate were significantly more accurate in identifying DE from MTX in both simulated and real datasets. Moreover, we show that when paired DNA measurements (metagenomic data) are not available, models normalizing MTX measurements within-species while also adjusting for total-species RNA balance sensitivity, specificity and interpretability of DE detection, as does filtering likely technical zeros. The efficiency and accuracy of these models pave the way for more effective MTX-based DE discovery in microbial communities. Microbial genomes are available at an ever-increasing pace, as cultivation and sequencing become cheaper and obtaining metagenome-assembled genomes (MAGs) becomes more effective. Phylogenetic placement methods to contextualize hundreds of thousands of genomes must thus be efficiently scalable and sensitive from closely related strains to divergent phyla. We present PhyloPhlAn 3.0, an accurate, rapid, and easy-to-use method for large-scale microbial genome characterization and phylogenetic analysis at multiple levels of resolution. PhyloPhlAn 3.0 can assign genomes from isolate sequencing or MAGs to species-level genome bins built from >230,000 publically available sequences. For individual clades of interest, it reconstructs strain-level phylogenies from among the closest species using clade-specific maximally informative markers. At the other extreme of resolution, it scales to large phylogenies comprising >17,000 microbial species. Examples including Staphylococcus aureus isolates, gut metagenomes, and meta-analyses demonstrate the ability of PhyloPhlAn 3.0 to support genomic and metagenomic analyses. Faecalibacterium is prevalent in the human gut and a promising microbe for the development of next-generation probiotics (NGPs) or biotherapeutics. Analyzing reference Faecalibacterium genomes and almost 3,000 Faecalibacterium-like metagenome-assembled genomes (MAGs) reconstructed from 7,907 human and 203 non-human primate gut metagenomes, we identified the presence of 22 different Faecalibacterium-like species-level genome bins (SGBs), some further divided in different strains according to the subject geographical origin. Twelve SGBs are globally spread in the human gut and show different genomic potential in the utilization of complex polysaccharides, suggesting that higher SGB diversity may be related with increased utilization of plant-based foods. Moreover, up to 11 different species may co-occur in the same subject, with lower diversity in Western populations, as well as intestinal inflammatory states and obesity. The newly explored Faecalibacterium diversity will be able to support the choice of strains suitable as NGPs, guided by the consideration of the differences existing in their functional potential. Acute graft-versus-host disease (aGVHD) is one of the major causes of death after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Recently, aGVHD onset was linked to intestinal microbiota (IM) dysbiosis. However, other bacterial-rich gastrointestinal sites, such as the mouth, which hosts several distinctive microbiotas, may also impact the risk of GVHD. The dental biofilm microbiota (DBM) is highly diverse and, like the IM, interacts with host cells and modulates immune homeostasis. We characterized changes in the DBM of patients during allo-HSCT and evaluated whether the DBM could be associated with the risk of aGVHD. DBM dysbiosis during allo-HSCT was marked by a gradual loss of bacterial diversity and changes in DBM genera composition, with commensal genera reductions and potentially pathogenic bacteria overgrowths. High Streptococcus and high Corynebacterium relative abundance at preconditioning were associated with a higher risk of aGVHD (67% vs. 33%; HR = 2.89, P = 0.04 and 73% vs. 37%; HR = 2.74, P = 0.04, respectively), while high Veillonella relative abundance was associated with a lower risk of aGVHD (27% vs. 73%; HR = 0.24, P < 0.01). Enterococcus faecalis bloom during allo-HSCT was observed in 17% of allo-HSCT recipients and was associated with a higher risk of aGVHD (100% vs. 40%; HR = 4.07, P < 0.001) and severe aGVHD (60% vs. 12%; HR = 6.82, P = 0.01). To the best of our knowledge, this is the first study demonstrating that DBM dysbiosis is associated with the aGVHD risk after allo-HSCT.https://cassyni-user-files-prod.s3.amazonaws.com/NCTFEEchmn8yjmpr4aBQhL https://cassyni.com/slides/outline/25WHED2BvvfaUpGx4T6kHB https://cassyni.com/events/25WHED2BvvfaUpGx4T6kHB/abstract https://cassyni-user-files-prod.s3.amazonaws.com/UgKSYyJApcwSRddQCEMiQN https://cassyni.com/events/25WHED2BvvfaUpGx4T6kHB?videoPreview=1 What happens to aerofoil noise when the aerofoil undergoes flow separation and stall?nohttps://cassyni.com/events/25WHED2BvvfaUpGx4T6kHB?videoPreview=12022-10-19T14:00:00+00:003375.04Department of Aeronautics and AstronauticsAerofoil flow separation and stall is a significant source of self-noise for many engineering applications, particularly when operating at high angles of attack in unsteady inflow conditions. After many years of studies on aerofoil noise, several questions remain regarding both the quantification and physical mechanisms of separation noise. One of the most fundamental questions yet to be determined is the role of quadrupole sources in contrast with dipoles. The majority of previous aerofoil noise investigations have considered low angles of attack, where the dipole noise generated by a turbulent boundary layer scattered at the trailing edge (TE) is usually considered to dominate the noise production. However, in the stall regime, the highest intensity flow structures typically appear away from the wall, indicating that the TE will generate sound less effectively. The conventional wisdom that dipole sound should dominate over quadrupole sound may therefore not apply for high angle of attack cases. This talk provides insight into the role of quadrupole sources due to separated shear layers at low Mach numbers, based on the results of direct numerical simulations. Image credit: [Yzy Pop (Unsplash)](https://unsplash.com/photos/a-view-of-a-mountain-range-from-an-airplane-window-SmrhgI5upFg).https://cassyni-user-files-prod.s3.amazonaws.com/UgKSYyJApcwSRddQCEMiQN https://cassyni.com/slides/outline/4YkJTdFp8DS4qkkWc91P17 https://cassyni.com/events/4YkJTdFp8DS4qkkWc91P17/abstract https://cassyni-user-files-prod.s3.amazonaws.com/BLL4nLxb8WbnRM8kQ6PJNS https://cassyni.com/events/4YkJTdFp8DS4qkkWc91P17?videoPreview=1 Axial spondyloarthritis patients have altered mucosal IgA response to oral and fecal microbiotanohttps://cassyni.com/events/4YkJTdFp8DS4qkkWc91P17?videoPreview=12022-04-12T10:00:00+00:00638.0Microbiome Virtual International Forum Objective To investigate whether axial spondyloarthritis (AxSpA) patients have an altered immunoglobulin A (IgA) response in the gut and oral microbial communities. Methods We performed 16S rRNA gene (16S) sequencing on IgA positive (IgA+) and IgA negative (IgA−) fractions (IgA-SEQ) from feces (n=17 AxSpA; n=14 healthy) and saliva (n=17 AxSpA; n=12 healthy), as well as on IgA-unsorted fecal and salivary samples. PICRUSt2 was used to predict microbial metabolic potential in AxSpA patients and healthy controls (HCs). Results IgA-SEQ revealed enrichment of several microbes in the fecal (Akkermansia, Ruminococcaceae, Lachnospira) and salivary (Prevotellaceae, Actinobacillus) microbiome in AxSpA patients as compared with HCs. Fecal microbiome from AxSpA patients showed a trend towards increased alpha diversity of the IgA+ fraction and decreased diversity in the IgA− fraction in comparison with HCs, while the salivary microbiome exhibits a significant decrease in alpha diversity in both IgA+ and IgA− fractions. Increased IgA coating of Clostridiales Family XIII correlated with disease severity. Inferred metagenomic analysis suggests perturbation of metabolites and metabolic pathways for inflammation (oxidative phosphorylation, glutathione metabolism) and metabolism (propanoate and butanoate metabolism) in AxSpA patients. Conclusions Analyses of fecal and salivary microbes from AxSpA patients reveal distinct populations of immunoreactive microbes using novel IgA-SEQ approach, which were not captured by comparing their relative abundance with HCs. Predictive metagenomic analysis revealed perturbation of metabolites/metabolic pathways in AxSpA patients. Future studies on these immunoreactive microbes may lead to better understanding of the functional role of IgA in maintaining microbial structure and human health.https://cassyni-user-files-prod.s3.amazonaws.com/BLL4nLxb8WbnRM8kQ6PJNS https://cassyni.com/slides/outline/CwmaFFFjazr4166yfzLSE1 https://cassyni.com/events/CwmaFFFjazr4166yfzLSE1/abstract https://cassyni-user-files-prod.s3.amazonaws.com/RnGNGi7oZnrxrugeBeFA9C https://cassyni.com/events/CwmaFFFjazr4166yfzLSE1?videoPreview=1 A faecal microbiota signature with high specificity for pancreatic cancernohttps://cassyni.com/events/CwmaFFFjazr4166yfzLSE1?videoPreview=12022-09-13T14:00:00+00:0064.6Microbiome Virtual International Forum Following recent evidence suggesting a role for the microbiome in PDAC etiology and progression, we explored the fecal and salivary microbiota as potential diagnostic biomarkers. Design: We applied shotgun metagenomic and 16S rRNA amplicon sequencing to samples from a Spanish case-control study (N=136), including 57 cases, 50 controls, and 29 chronic pancreatitis patients in the discovery phase, and from a German case-control study (N=76), in the validation phase. Results: Fecal metagenomic classifiers performed much better than saliva-based ones and identified PDAC cases with an accuracy of up to 0.84 AUROC based on a set of 27 microbial species, with consistent accuracy across early and late disease stages. Performance further improved to up to 0.94 AUROC when we combined our microbiome-based predictions with serum levels of carbohydrate antigen (CA) 19-9, the only current non-invasive, FDA-approved, low specificity PDAC diagnostic biomarker. Furthermore, a microbiota-based classification model constrained to PDAC-enriched species was highly disease-specific when validated against 25 publicly available metagenomic study populations for various health conditions (N=5,792). Both microbiome-based models had a high prediction accuracy on an external German validation population (N=76). Several fecal PDAC marker species were detectable in pancreatic tumor and non-tumor tissue using 16S rRNA sequencing and fluorescence in situ hybridization. Conclusion: Taken together, our results indicate that non-invasive, robust and specific fecal microbiota-based screening for the early detection of PDAC is feasible. Link to OA paper: https://gut.bmj.com/content/71/7/1359https://cassyni-user-files-prod.s3.amazonaws.com/RnGNGi7oZnrxrugeBeFA9C https://cassyni.com/slides/outline/BxUN9sxgi5juLLGya1s7R7 https://cassyni.com/events/BxUN9sxgi5juLLGya1s7R7/abstract https://cassyni-user-files-prod.s3.amazonaws.com/7iyhTF7kBevqGdXXERZjxa https://cassyni.com/events/BxUN9sxgi5juLLGya1s7R7?videoPreview=1 From prehistory to precision: using the Neanderthal oral microbiome to develop oral microbiome transplantationnohttps://cassyni.com/events/BxUN9sxgi5juLLGya1s7R7?videoPreview=12024-02-27T10:00:00+00:002064.04Microbiome Virtual International Forum No abstracthttps://cassyni-user-files-prod.s3.amazonaws.com/7iyhTF7kBevqGdXXERZjxa https://cassyni.com/slides/outline/NL7gEs4bL4J41KGWsgkSjF https://cassyni.com/events/NL7gEs4bL4J41KGWsgkSjF/abstract https://cassyni-user-files-prod.s3.amazonaws.com/HNxsLny25QBcsbt72KDtyc https://cassyni.com/events/NL7gEs4bL4J41KGWsgkSjF?videoPreview=1 Establishment of a non-Westernized gut microbiota in men who have sex with men is associated with sexual practicesnohttps://cassyni.com/events/NL7gEs4bL4J41KGWsgkSjF?videoPreview=12024-03-20T13:00:00+00:00651.04Microbiome Virtual International Forum The human gut microbiota is influenced by various factors, including health status and environmental conditions, yet considerable inter-individual differences remain unexplained. Previous studies identified that the gut microbiota of men who have sex with men (MSM) is distinct from that of non-MSM. Here, we reveal through species-level microbiota analysis using shotgun metagenomics that the gut microbiota of many MSM with Western origin resembles gut microbial communities of non-Westernized populations. Specifically, MSM gut microbiomes are frequently dominated by members of the Prevotellaceae family, including co-colonization of species from the Segatella copri complex and unknown Prevotellaceae members. Questionnaire-based analysis exploring inter-individual differences in MSM links specific sexual practices to microbiota composition. Moreover, machine learning identifies microbial features associated with sexual activities in MSM. Together, this study shows associations of sexual activities with gut microbiome alterations in MSM, which may have a large impact on population-based microbiota studies. Link to publication: https://www.sciencedirect.com/science/article/pii/S2666379124000491https://cassyni-user-files-prod.s3.amazonaws.com/HNxsLny25QBcsbt72KDtyc https://cassyni.com/slides/outline/NpmHHYi7mWr715oQU83EzZ https://cassyni.com/events/NpmHHYi7mWr715oQU83EzZ/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Nmc6gHDv4Kq2GVuLPQFBvN https://cassyni.com/events/NpmHHYi7mWr715oQU83EzZ?videoPreview=1 The Marie Project: The Vaginal Microbiome & Menstrual Health in Switzerland and Beyondnohttps://cassyni.com/events/NpmHHYi7mWr715oQU83EzZ?videoPreview=12024-06-11T14:00:00+00:001228.0Microbiome Virtual International Forum Isala started in 2020 with more than 6000 women in Belgium willing to learn about their vaginal microbes and their relationship with their health. Today, Isala has inspired more than ten projects in other countries, united under the mission to improve women's health through investigation of the vaginal microbiome. This talk presents Marie, the Swiss sister project, and the first official collaboration between projects from the Isala sisterhood: Laura, Leke, Marie, and Isala. This collaboration interlinks fundamental biomedical research with social sciences methodologies to generate research evidence on the impact of menstrual products on the vaginal microbiome, complemented with women’s views, perceptions, and concerns about menstrual health management. Hand in hand with international policymakers, local organizations and the private sector, the four sisters want to bring knowledge of the impact of menstrual products on the vaginal microbiome to the current agenda on menstrual health. https://cassyni-user-files-prod.s3.amazonaws.com/Nmc6gHDv4Kq2GVuLPQFBvN https://cassyni.com/slides/outline/HPddn2bLwUm2cDZAsD3T17 https://cassyni.com/events/HPddn2bLwUm2cDZAsD3T17/abstract https://cassyni-user-files-prod.s3.amazonaws.com/B5fntSxC5TD1pDNqpzhjqg https://cassyni.com/events/HPddn2bLwUm2cDZAsD3T17?videoPreview=1 Microbial community-scale metabolic modeling predicts personalized short-chain-fatty-acid production profiles in the human gutnohttps://cassyni.com/events/HPddn2bLwUm2cDZAsD3T17?videoPreview=12023-11-14T11:00:00+00:0069.76Microbiome Virtual International Forum Microbially-derived short-chain fatty acids (SCFAs) in the human gut are tightly coupled to host metabolism, immune regulation, and integrity of the intestinal epithelium. However, the production of SCFAs can vary widely between individuals consuming the same diet, with lower levels often associated with disease. A mechanistic understanding of this heterogeneity is lacking. We present a microbial community-scale metabolic modeling (MCMM) approach to predict individual-specific SCFA production profiles. We assess the quantitative accuracy of our MCMMs using in vitro, ex vivo, and in vivo data. Next, we identify associations between MCMM SCFA predictions and a panel of blood-based clinical chemistries in a large human cohort. Finally, we demonstrate how MCMMs can be leveraged to design personalized dietary, prebiotic, and probiotic interventions that optimize SCFA production in the gut. Our results represent an important advance in engineering gut microbiome functional outputs for precision health and nutrition.https://cassyni-user-files-prod.s3.amazonaws.com/B5fntSxC5TD1pDNqpzhjqg https://cassyni.com/slides/outline/Vjqjw7mTuvbtVtnyqZcB9F https://cassyni.com/events/Vjqjw7mTuvbtVtnyqZcB9F/abstract https://cassyni-user-files-prod.s3.amazonaws.com/JFNuKHW3sZR6x5qQ6P6J6J https://cassyni.com/events/Vjqjw7mTuvbtVtnyqZcB9F?videoPreview=1 curatedMetagenomicData 3 allows meta-analysis of 22,710 human metagenomes in relation with host phenotype and health-outcomes and defines an oral to gut microbial introgression scorenohttps://cassyni.com/events/Vjqjw7mTuvbtVtnyqZcB9F?videoPreview=12023-03-14T11:00:00+00:0074.64Microbiome Virtual International Forum Publicly available microbiome data have become of sufficient scope for meta-analysis on a range of phenotypes, conditions, and health-related outcomes. This led to unprecedented results that were made possible thanks to the effort of integration of multiple microbiome cohorts. The wide-spread exploitation of public metagenomic dataset is however hampered by the lack of accessibility and standardization that are barriers to their use. To allow fast and convenient acquisition and harmonization of public microbiome data, we have developed curatedMetagenomicData (cMD) 3, an R/Biocoductor data-package deploying 22,710 publicly available human metagenomic samples from 94 cohorts and 42 countries. Samples in cMD 3 are uniformly profiled via the bioBakery 3 softwares MetaPhlAn 3 and HUMAnN 3.0, respectively for the taxonomic and the functional potential profiling. In addition, cMD 3 provides sample- and subject-related manually curated clinical and technical attributes organised in a coded vocabulary, allowing the easy retrieval and re-usage of microbiome datasets. In this resource paper, we present cMD 3. We use it to address several challenges in the current human microbiome epidemiology, with greater sample size and diversity of populations than previously possible. Via random-effects meta-analysis we identify species and metabolic features associated with sex (102 taxa, 15 Metacyc pathways, and 226 KEGG-Orthologs, Q lower than 0.01), age (91 taxa and 1,991 functions, Q lower than 0.01) or BMI (195 taxa and 1,018 functions, Q lower than 0.01). We investigate cross-disease, cross-cohort (15 diseases, 30 cohorts) species-level and pathway-level associations (34 species and 215 pathways, Q lower than 0.01). We then use the oral samples available through cMD 3 to define a simple “oral to gut introgression” score that can be easily calculated in any fecal sample as the summed relative abundance of 305 species identified from 425 oral metagenomes. This score is more frequently elevated than decreased in diseases (27 of 30 studies, P = 8.4 x 10-6, binomial test), representing a quantitative index of deviation from health-associated microbiome configurations. Together these analyses show the potential of the novel cMD 3, assessing the relationship between human microbiome and basic and clinical host outcomes and identifying modest but widely shared variation in human microbiomes that will serve as a reproducible and readily updatable reference.https://cassyni-user-files-prod.s3.amazonaws.com/JFNuKHW3sZR6x5qQ6P6J6J https://cassyni.com/slides/outline/TGbihhXqidqMTjZCNmop93 https://cassyni.com/events/TGbihhXqidqMTjZCNmop93/abstract https://cassyni-user-files-prod.s3.amazonaws.com/NtUi5RqMdtaRwFrPzva7HG https://cassyni.com/events/TGbihhXqidqMTjZCNmop93?videoPreview=1 A Practical Guide to Therapeutic Drug Monitoring in Busulfan: Recommendations from the Pharmacist Committee of the European Society for Blood and Marrow Transplantation (EBMT)nohttps://cassyni.com/events/TGbihhXqidqMTjZCNmop93?videoPreview=12024-09-30T12:00:00+00:001458.32Bone Marrow TransplantationBusulfan (Bu) is an important component of many conditioning regimens for allogeneic hematopoietic cell transplantation. The therapeutic window of Bu is well characterized, with strong associations between Bu exposure and the clinical outcome in adults (strongest evidence in myelo-ablative setting) and children (all settings). We provide an overview of the literature on Bu as well as a step-by-step guide to the implementation of Bu therapeutic drug monitoring (TDM). The guide covers the clinical, pharmacological, laboratory and administrative aspects of the procedure. Through this document, we aim to support centers in implementing TDM for Bu to further enhance the success rates of HCT and improve patient outcomes. The Pharmacist Committee of the European Society for Blood and Marrow Transplantation (EBMT) encourages all centers to perform TDM for Bu in the aforementioned indications. https://cassyni-user-files-prod.s3.amazonaws.com/NtUi5RqMdtaRwFrPzva7HG https://cassyni.com/events/81K9u3JNbnEUh9WhTUDWSq/abstract https://cassyni-user-files-prod.s3.amazonaws.com/3E4JFxH27mN2B7cMtjyaKg https://cassyni.com/slides/outline/WiritBuemESmhsey5rh5dw https://cassyni.com/events/WiritBuemESmhsey5rh5dw/abstract https://cassyni-user-files-prod.s3.amazonaws.com/KQGMs8n4x3xuHoA7myvgyk https://cassyni.com/events/WiritBuemESmhsey5rh5dw?videoPreview=1 Effect of translation-rotation coupling motion on a 3-Dof horizontal vibration isolation systemnohttps://cassyni.com/events/WiritBuemESmhsey5rh5dw?videoPreview=12025-06-24T10:00:00+00:001046.16NODYSCoupling motion inevitably occurs to multi-DOF (Degrees of Freedom) vibration isolators. While complex structures may introduce coupling, additional factors like manufacturing errors and variations in experimental setup also contribute. This paper examines a 3-DOF horizontal vibration isolation system composed of four isolator units, focusing on the translation-rotation motion induced by deviations of the payload center. A mechanical model of the system is developed using the energy method, resulting in a dynamic equation with nonlinear parameters. The impact of these nonlinear parameters on the system's response and bifurcation analysis are explored to reveal key principles governing translational and rotational motion.https://cassyni-user-files-prod.s3.amazonaws.com/KQGMs8n4x3xuHoA7myvgyk https://cassyni.com/slides/outline/RHj5NfnswCMhK1QjUwhHeV https://cassyni.com/events/RHj5NfnswCMhK1QjUwhHeV/abstract https://cassyni-user-files-prod.s3.amazonaws.com/DqzwD5GJR1fwiDYUK8FbpJ https://cassyni.com/events/RHj5NfnswCMhK1QjUwhHeV?videoPreview=1 Wheel shimmy suppression through the piecewise nonlinear energy sink: elimination of detrimental isolasnohttps://cassyni.com/events/RHj5NfnswCMhK1QjUwhHeV?videoPreview=12025-06-24T10:00:00+00:00600.32NODYSSelf-excited shimmy deteriorates the stability and safety of almost every type of vehicle. The triggering mechanism of shimmy has been thoroughly analyzed, but the most typical suppression methodology is not always applicable in many systems, since it affects the prescribed handling performance. In this paper, based on the recent advancement in the nonlinear energy sink (NES), we propose an approach to globally mitigate the shimmy of a towed wheel through an ungrounded NES. The cubic NES, although exhibits good performance, is lacking robustness against external perturbations because an isolated branch of large amplitude oscillations coexists with a favorable small amplitude quasi-periodic motion. Then, an NES with non-smooth damping characteristics is developed, which proved to be able to completely suppress the detrimental isola, without reducing performance; thus, representing an effective and robust solution for shimmy mitigation.https://cassyni-user-files-prod.s3.amazonaws.com/DqzwD5GJR1fwiDYUK8FbpJ https://cassyni.com/slides/outline/62SWa1ZQpLkpYRNEZe6yxH https://cassyni.com/events/62SWa1ZQpLkpYRNEZe6yxH/abstract https://cassyni-user-files-prod.s3.amazonaws.com/G4v9v9gAPaAPEfNUc3ZyGS https://cassyni.com/events/62SWa1ZQpLkpYRNEZe6yxH?videoPreview=1 Harmonically excited capsule robot with nonlinear von Mises trussnohttps://cassyni.com/events/62SWa1ZQpLkpYRNEZe6yxH?videoPreview=12025-06-24T11:00:00+00:00773.12NODYSThis study explores the integration of a von Mises truss into a vibro-impact capsule robot, a piecewise-smooth dynamical system known for its complex coexistence of attractors, to enhance its progression speed. The research employs numerical bifurcation analysis to evaluate the effects of frequency and amplitude of the robot’s driving force on its locomotion. Utilizing numerical continuation techniques within the COCO platform (Dankowicz & Schilder), we systematically compare the periodic responses of capsule robots both with and without the von Mises truss.https://cassyni-user-files-prod.s3.amazonaws.com/G4v9v9gAPaAPEfNUc3ZyGS https://cassyni.com/slides/outline/8VgXoRo31dXJuMqo7L1cgD https://cassyni.com/events/8VgXoRo31dXJuMqo7L1cgD/abstract https://cassyni-user-files-prod.s3.amazonaws.com/B8S7TKCuzzdMqZf8bZryYJ https://cassyni.com/events/8VgXoRo31dXJuMqo7L1cgD?videoPreview=1 Characterization of a Hoisting Device using Variable Length Control and Real-Time Gyroscopic Datanohttps://cassyni.com/events/8VgXoRo31dXJuMqo7L1cgD?videoPreview=12025-06-24T11:00:00+00:00727.28NODYSThis paper presents a characterization of a hoisting device using variable length control and real-time gyroscopic data. The aim is to stabilize low-mass payloads in medical evacuation (MEDEVAC) rescues. Some of the co-authors previously presented the variable length hoisting control scheme at NODYCON 2021, and preliminary testing results of a first-generation hoisting device were presented at NODYCON 2023. This paper presents the characterization of a second-generation device that hoists the payload attached to a 6 m cable using real-time gyroscopic data; a more detailed analysis of testing videos; and a comparison of constant pull-up test results with numerical simulation results. Test results show that this second-generation device reduces the swing angle from 18.7 deg to 9.6 deg in 55.3 s (13 oscillations). In comparison, the swing angle of a free-swinging cable reduces from 18.9 deg to 9.4 deg in 75.8 s (16 oscillations).https://cassyni-user-files-prod.s3.amazonaws.com/B8S7TKCuzzdMqZf8bZryYJ https://cassyni.com/slides/outline/GQ5pezfKSKJyDQMmsJzKGR https://cassyni.com/events/GQ5pezfKSKJyDQMmsJzKGR/abstract https://cassyni-user-files-prod.s3.amazonaws.com/QotBSL1FMSAthJjesTQY7p https://cassyni.com/events/GQ5pezfKSKJyDQMmsJzKGR?videoPreview=1 Mitigation of the toroidal Alfvén Eigenmodes in Negative Triangularity plasmas at the TCV tokamaknohttps://cassyni.com/events/GQ5pezfKSKJyDQMmsJzKGR?videoPreview=12025-02-13T16:00:00+00:001632.04Journal of Plasma PhysicsFast ion confinement, and particularly alpha particles, is key for the development of a successful fusion power plant (FPP), as they should be the main heating and current drive mechanism. Instabilities in plasmas, like Alfvén eigenmodes, can be excited by large fast ion populations and can result in an untamable loss of power, as well as damage to the reactor vessel[1-3]. 3D Nonhttps://cassyni-user-files-prod.s3.amazonaws.com/QotBSL1FMSAthJjesTQY7p https://cassyni.com/slides/outline/8zMkxjxSrT1TTNAsK9NgpM https://cassyni.com/events/8zMkxjxSrT1TTNAsK9NgpM/abstract https://cassyni-user-files-prod.s3.amazonaws.com/TmmoiRtPzBVXQTGYqnPRfc https://cassyni.com/events/8zMkxjxSrT1TTNAsK9NgpM?videoPreview=1 New insights in old problems: waves in ion-electron plasmasnohttps://cassyni.com/events/8zMkxjxSrT1TTNAsK9NgpM?videoPreview=12024-08-22T15:00:00+00:003042.8Journal of Plasma PhysicsI will review our recent findings on waves in ion-electron plasmas, where we introduced a novel convenient labeling scheme that uniquely identifies each of the six wave pairs: S-A-F-M-O-X. In contrast to textbook treatments, our labeling does not start from the specific behavior at exactly parallel or exactly perpendicular orientation between wave vector and magnetic field, but recognizes the clear frequency ordering obeyed by the six wave pairs at all other (oblique) orientations. Our treatment is completely general for any two-fluid view on ion-electron plasmas, and the dispersion relation is conveniently expressed in polynomial expressions. The effect of collisions can be included and quantified for every wave type at all wavelengths. Important parameters include the magnetization and make our findings valid for extreme plasma conditions where the magnetohydrodynamic slow-alfven-fast (S-A-F) waves are given by their relativistically correct expressions. Special cases (cold plasmas, pair plasmas, …) are recovered and findings on Faraday rotation of electromagnetic (O-X) waves are easily generalized.https://cassyni-user-files-prod.s3.amazonaws.com/TmmoiRtPzBVXQTGYqnPRfc https://cassyni.com/slides/outline/BTbnCAC53jmwpJeRrqHKYH https://cassyni.com/events/BTbnCAC53jmwpJeRrqHKYH/abstract https://cassyni-user-files-prod.s3.amazonaws.com/NLeACumdA9Q5bpvXv4FoRx https://cassyni.com/events/BTbnCAC53jmwpJeRrqHKYH?videoPreview=1 Subion-scale turbulence driven by Magnetic Reconnectionnohttps://cassyni.com/events/BTbnCAC53jmwpJeRrqHKYH?videoPreview=12023-05-25T16:00:00+00:001986.36Journal of Plasma PhysicsThe interplay between plasma turbulence and magnetic reconnection remains an unsettled question in astrophysical and laboratory plasmas. Here we report the first observational evidence that magnetic reconnection drives subion-scale turbulence in magnetospheric plasmas by transferring energy to small scales. We employ a spatial coarse-grained model of Hall magnetohydrodynamics, enabling us to measure the nonlinear energy transfer rate across scale ℓ at position x. Its application to Magnetospheric Multiscale mission data shows that magnetic reconnection drives intense energy transfer to subion-scales. This observational evidence is remarkably supported by the results from Hybrid Vlasov-Maxwell simulations of turbulence to which the coarse-grained model is also applied. These results open new pathways to investigate the interplay between turbulence, reconnection and energy dissipation in collisionless magnetized plasmas and can potentially explain spacecraft observations in various planetary magnetosheaths that showed the ubiquity of turbulent fluctuations at sub-ion scales even when no energy cascade emerges from the larger (MHD) scales.https://cassyni-user-files-prod.s3.amazonaws.com/NLeACumdA9Q5bpvXv4FoRx https://cassyni.com/slides/outline/PoqWTst5RYYXrTae7knVK3 https://cassyni.com/events/PoqWTst5RYYXrTae7knVK3/abstract https://cassyni-user-files-prod.s3.amazonaws.com/EqmECeNt6cMfUsqEiHf5QA https://cassyni.com/events/PoqWTst5RYYXrTae7knVK3?videoPreview=1 Relativistic magnetospheres: current sheets, reconnection, particle accelerationnohttps://cassyni.com/events/PoqWTst5RYYXrTae7knVK3?videoPreview=12022-09-29T15:00:00+00:003503.24Journal of Plasma PhysicsSpinning neutrons stars and black holes are the central engines of some of the most extreme astrophysical phenomena such as gamma-ray bursts, pulsars, X-ray binaries, binary mergers or active galactic nuclei. The activity of these compact objects is often associated with the creation and the launching of a relativistic magnetized plasma within their magnetospheres. Similarly to their non-relativistic analog in the Solar System, these magnetospheres are highly dynamical. Large-scale current sheets form and reconnect, leading to efficient particle acceleration, pair production and non-thermal radiation. However, the interplay between general relativity, quantum electrodynamics and plasma physics makes this problem not easily tractable. In this talk, I will review current efforts to model pulsar and black hole magnetospheres from first principles by means of global particle-in-cell simulations. Results will be discussed in the context of gamma-ray pulsars, and recent horizon-scale observations of the weakly accreting supermassive black holes M87* and SgrA*.https://cassyni-user-files-prod.s3.amazonaws.com/EqmECeNt6cMfUsqEiHf5QA https://cassyni.com/slides/outline/JNhrxMmJbWTTTbLQWqnhKb https://cassyni.com/events/JNhrxMmJbWTTTbLQWqnhKb/abstract https://cassyni-user-files-prod.s3.amazonaws.com/HQA7k5JNmZs4CjDBuaYohp https://cassyni.com/events/JNhrxMmJbWTTTbLQWqnhKb?videoPreview=1 Quantum-inspired methods for solving the Vlasov-Poisson equationnohttps://cassyni.com/events/JNhrxMmJbWTTTbLQWqnhKb?videoPreview=12022-05-12T15:00:00+00:003355.6Journal of Plasma PhysicsKinetic simulations of collisionless (or near-collisionless) plasmas using the Vlasov equation are often infeasible due to high resolution requirements and the exponential scaling of computational cost with respect to dimension. Recently, it has been proposed that matrix product state (MPS) methods, a quantum-inspired but classical algorithm, can be used to approximately solve partial differential equations with exponential speed up, provided that the solution can be compressed and efficiently represented as an MPS within some tolerable error threshold. In this work, we explore the practicality of MPS methods for solving the Vlasov-Poisson equations in 1D1V, and find that important features of linear and nonlinear dynamics, such as damping rates and saturation energies, can still be captured while compressing the solution by at least a factor of 8. Furthermore, by comparing the performance of different mappings of the distribution functions onto the MPS, we generate some intuition of the MPS representation and its behavior, which will be useful for extending these methods to higher dimensional problems.https://cassyni-user-files-prod.s3.amazonaws.com/HQA7k5JNmZs4CjDBuaYohp https://cassyni.com/events/JsMU13Qq2y1WTMsJ7H5Vau/abstract https://cassyni-user-files-prod.s3.amazonaws.com/KsQ8yVXzxrdbEtSyNNMAi2 https://cassyni.com/events/VEy9yPzrFadvysAS8P2PGR/abstract https://cassyni-user-files-prod.s3.amazonaws.com/EZ83UDfMpDVv3wcJvrHKH8 https://cassyni.com/slides/outline/RnRvecUBBNmHxArsUieRjb https://cassyni.com/events/RnRvecUBBNmHxArsUieRjb/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Aj8U5VagipUtDNj5bw98Hc https://cassyni.com/events/RnRvecUBBNmHxArsUieRjb?videoPreview=1 Anomalous Electron Diffusion in Magnetic Islands and Stochastic Magnetic Fieldsnohttps://cassyni.com/events/RnRvecUBBNmHxArsUieRjb?videoPreview=12022-01-20T16:00:00+00:003689.32Journal of Plasma PhysicsMagnetic islands and regions of stochastic magnetic fields originate from the dynamical processes of magnetic reconnection and turbulence in plasma. These structures are ubiquitous in both laboratory settings (e.g., tokamaks and stellarators) and space environment (e.g., solar wind plasma and Earth’s magnetosphere). An interesting feature of magnetic islands and stochastic regions in plasmas is their connection to plasma particle acceleration, often resulting in anomalous diffusion. An important question is what universal principles relate the properties of energetic particles as a function of the underlying magnetic field topology in both lab and space. The answer to this question requires the development of universal transport models.https://cassyni-user-files-prod.s3.amazonaws.com/Aj8U5VagipUtDNj5bw98Hc https://cassyni.com/events/UFfwt2hoNfXnK7LS2QZ4TX/abstract https://cassyni.com/events/53CYhuJ8k9W2pBQbCbj5r5/abstract https://cassyni.com/slides/outline/7WSZwKXkwSGXB7t9kHdia1 https://cassyni.com/events/7WSZwKXkwSGXB7t9kHdia1/abstract https://cassyni-user-files-prod.s3.amazonaws.com/73dwqDUgAZiLmg1k8dLRq8 https://cassyni.com/events/7WSZwKXkwSGXB7t9kHdia1?videoPreview=1 Design of the first fusion laboratory experiment to achieve target gain > 1nohttps://cassyni.com/events/7WSZwKXkwSGXB7t9kHdia1?videoPreview=12023-03-30T15:00:00+00:002968.8Journal of Plasma PhysicsThe inertial fusion community have been working towards ignition for decades, since the idea of inertial confinement fusion (ICF) was first proposed by Nuckolls, et al., in 1972. On August 8, 2021 and Dec 5th 2022, the Lawson criterion for ignition was met and more fusion energy was created than laser energy incident on the target at the National Ignition Facility (NIF) in Northern California. The first experiment produced a fusion yield of 1.35 MJ from 1.9 MJ of laser energy and appears to have crossed the tipping-point of thermodynamic instability according to several ignition metrics. Building on this result, improvements were made to increase the fusion energy output to >3MJ from 2.05 MJ of laser energy on target, resulting in target gain exceeding unity for the first time in the laboratory. This result is important in that it proves that there is nothing fundamentally limiting controlled fusion energy gain in the laboratory.https://cassyni-user-files-prod.s3.amazonaws.com/73dwqDUgAZiLmg1k8dLRq8 https://cassyni.com/slides/outline/MpD43rEBmN4FiiYRmj4iBX https://cassyni.com/events/MpD43rEBmN4FiiYRmj4iBX/abstract https://cassyni-user-files-prod.s3.amazonaws.com/BjpHjsY6kuFK8oNzm3n3Dx https://cassyni.com/events/MpD43rEBmN4FiiYRmj4iBX?videoPreview=1 Varicocele embolization outcomes of primary or post-surgery recurrent varicoceles in children.nohttps://cassyni.com/events/MpD43rEBmN4FiiYRmj4iBX?videoPreview=12025-10-16T09:47:36+00:00870.0Society for Pediatric Interventional Radiology## Introduction Varicoceles may cause pain, testicular atrophy, and potentially future infertility. Study to determine imaging and clinical outcomes of primary or post-surgery varicocele embolization (VE). ## Materials and Methods Study approved by the Research Ethics Board. Retrospective review of VE patients <=18 years old from January 2000 to December 2024. Demographics and procedure data collected. Imaging (vessel size) and clinical (symptoms and/ or testicular size) success, and reasons for post-surgery recurrence evaluated. ## Results 34 patients included (18 post-surgery). Mean age at surgery 13.8 (10.7-17.1) years and at embolization 14.8 (4.7-18.0) years. All varicoceles were left sided but 2 (bilateral). Clinically, 28 were grade III, 1 grade II, 2 contralateral grade 0 and 5 grade unavailable. VE indications were pain/discomfort in 19, testicular asymmetry >20%/contralateral atrophy/solitary testis in14, and patient/parental preference in 4. Bahren venography classification was: 12 - I, 7 - II, 11 - III and 4 - IV. Previous surgery included 4 laparoscopic artery +/- lymphatic sparing Palomo, 12 subinguinal artery +/- lymphatic sparing microsurgical and 2 unavailable. Aside from 4 patients, all tributaries/collaterals treated at venography were proximal to the level of varicocelectomy clips confirming surgical occlusion of the main vein. Procedure technical success was 94% (32/34). SIR minor complications occurred in 34.3% (11/32). Mean follow-up duration was 1 year (0.1-3.1; 2 lost to follow-up). Overall resolution/improvement noted in 97% (31/32), including symptom resolution/improvement in 18/20 and testicular asymmetry reduction in 8/9. ## Discussion VE has a high success rate with minor complications. Post varicocelectomy recurrence is predominantly related to collateral venous anatomy.https://cassyni-user-files-prod.s3.amazonaws.com/BjpHjsY6kuFK8oNzm3n3Dx https://cassyni.com/slides/outline/AUGwzAP8mTk51582UHsZ6m https://cassyni.com/events/AUGwzAP8mTk51582UHsZ6m/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Ay7HpTZURHydMF3QCPGr2i https://cassyni.com/events/AUGwzAP8mTk51582UHsZ6m?videoPreview=1 Is Digital the solution for NZ Sustainability Challenges?nohttps://cassyni.com/events/AUGwzAP8mTk51582UHsZ6m?videoPreview=12022-06-15T23:00:00+00:004361.76Business SchoolNew Zealand faces significant sustainability challenges, with enterprises largely at the initial stages of their sustainability journey, often driven by compliance obligations rather than holistic integration. A prevailing 'clean and green' national perception often contrasts with actual business practices. A key barrier to advancing digital sustainability initiatives is a lack of clear return on investment, with a recent study indicating 70% of businesses do not prioritize this area. Digital technology is presented as an essential enabler for addressing complex sustainability problems, facilitating tracking, decision-making, and the development of new solutions. Efforts are underway to bridge this gap, including the establishment of an NZ Tech sustainability sub-board and a FinTech sustainability working group. These initiatives aim to position the tech industry as a catalyst for other sectors and to promote green financing and financial incentives. The development of a digital sustainability index provides a framework for integrating digital transformation with sustainability objectives. The pathway forward necessitates a collaborative, multi-stakeholder approach, involving government, large enterprises, and the tech sector, to support small and medium enterprises in adopting sustainable practices. This includes creating accessible tools for compliance and fostering a mindset shift from risk aversion to embracing sustainability as an opportunity for innovation and new business models. A technology roadmap is being developed to accompany the national emissions reduction plan, initially focusing on key industries such as finance, seafood, energy, and tourism, to drive tangible outcomes and support an equitable transition towards a more sustainable and re-imagined economy.https://cassyni-user-files-prod.s3.amazonaws.com/Ay7HpTZURHydMF3QCPGr2i https://cassyni.com/events/XhgM2rSdo1ofExAbANzMGq/seminar/qa https://cassyni.com/slides/outline/XhgM2rSdo1ofExAbANzMGq https://cassyni.com/events/XhgM2rSdo1ofExAbANzMGq/abstract https://cassyni-user-files-prod.s3.amazonaws.com/VUwDF9KkUzuzkqqpprrZUi https://cassyni.com/events/XhgM2rSdo1ofExAbANzMGq?videoPreview=1 Beyond the limitations of passive acoustic metamaterials using dispersion engineering and complex frequency excitationsnohttps://cassyni.com/events/XhgM2rSdo1ofExAbANzMGq?videoPreview=12022-10-18T13:00:00+00:003897.4MetaMATIn this talk, we discuss our latest results on acoustic metamaterials, in which we theoretically introduce and experimentally demonstrate complex dispersion engineering of acoustic waves on elastic metamaterials, and excitation at complex frequencies to realize virtual absorption and virtual gain. Our results open new avenues for sound manipulation using metamaterials, going beyond conventional limits. We will discuss the basic principles behind the described phenomena and the implications for technologies.https://cassyni-user-files-prod.s3.amazonaws.com/VUwDF9KkUzuzkqqpprrZUi https://cassyni.com/slides/outline/ATDHeEoTTkYTQVz1v1L7Ho https://cassyni.com/events/ATDHeEoTTkYTQVz1v1L7Ho/abstract https://cassyni-user-files-prod.s3.amazonaws.com/DcjfgCc8aWgKwHfc2qyLHt https://cassyni.com/events/ATDHeEoTTkYTQVz1v1L7Ho?videoPreview=1 Biophysics in Africa: Cryptic No More: Characterising a Novel Allosteric Site in the HIV-1 Protease Cantilever Regionnohttps://cassyni.com/events/ATDHeEoTTkYTQVz1v1L7Ho?videoPreview=12025-06-25T06:00:00+00:005476.0Springer Nature Physics CommunityHIV-1 protease is a critical enzyme for viral maturation and one of the most well-studied proteins in structural biology. While much attention has focused on its active site, there is interest in how the enzyme might interact with small molecules at other regions on its surface. In particular, some of these potential sites, called cryptic pockets, are not visible in the unbound structure and only emerge under certain conditions. Until now, no cryptic sites had been identified in HIV-1 protease. We used mixed-solvent molecular dynamics simulations to uncover a previously unrecognised cryptic pocket in the cantilever region of the enzyme. Interestingly, this region shows conserved structural behaviour across related retroviral proteases, hinting at a broader functional role. When we locked this region in place using disulfide cross-linking, the protease adopted a distinct semi-open conformation, suggesting that the cantilever region influences flap movement. We then performed fragment-based screening which revealed that this cryptic pocket can bind small molecules. Simulations with one such fragment showed that binding alters the dynamics of the protease, particularly in the flap region. Overall, our findings highlight the cantilever region as a key regulatory element in HIV-1 protease function and a promising target for future drug discovery efforts.https://cassyni-user-files-prod.s3.amazonaws.com/DcjfgCc8aWgKwHfc2qyLHt https://cassyni.com/slides/outline/KLfBZWKp976j514PCrLA1K https://cassyni.com/events/KLfBZWKp976j514PCrLA1K/abstract https://cassyni-user-files-prod.s3.amazonaws.com/QnvmDLNkTgLfy28Hway27G https://cassyni.com/events/KLfBZWKp976j514PCrLA1K?videoPreview=1 Biocomplexity and Network Science: A symbiotic relationshipnohttps://cassyni.com/events/KLfBZWKp976j514PCrLA1K?videoPreview=12026-04-10T17:00:00+00:002880.44School of Data ScienceBiocomplexity refers to the study of biological, social, informational and technological agents, their interactions and the ecologies they form and evolve. These agents can be living agents but importantly can include artificial agents such as the ones created by today's AI systems. These agent ecologies are complex systems and reasoning about them is complicated and scientifically challenging due to their size, co-evolutionary nature and multiple scales and types of interactions simultaneously. Examples include human immune system, human brain, The 2019 COVID-19 pandemic, 2009 financial crisis, global migration, information propagation over social media, agentic AI and climate change. Advances in computing have fundamentally altered how such bio-social complex systems can be synthesized, analyzed and reasoned. Networked Dynamical systems and digital twins of the at-scale bio-social networks provide formal models and associated data structures to represent large co-evolving bio-social complex systems. After a brief introduction, the talk will discuss these two concepts with the aim of developing scalable and practical decision support systems for such coevolving bio-social complex systems. The role of AI and high performance computing will be highlighted. I will draw on our work in urban transport planning, energy systems and public health epidemiology to guide the discussion. https://cassyni-user-files-prod.s3.amazonaws.com/QnvmDLNkTgLfy28Hway27G https://cassyni.com/slides/outline/9xNKo9YjCmWGiUPwNLBpZ3 https://cassyni.com/events/9xNKo9YjCmWGiUPwNLBpZ3/abstract https://cassyni-user-files-prod.s3.amazonaws.com/EBh4Sg5GhwxGXYcfZiQ1GJ https://cassyni.com/events/9xNKo9YjCmWGiUPwNLBpZ3?videoPreview=1 Proteolytic Activation of Influenza A Virus Hemagglutinin in the Airway Epitheliumnohttps://cassyni.com/events/9xNKo9YjCmWGiUPwNLBpZ3?videoPreview=12026-03-04T11:00:00+00:003315.56Journal of Virology In this Journal of Virology Seminar Series, Dr. Michael Vahey presents his lab’s recent studies on the proteolytic activation of influenza A viruses (IAVs). IAVs utilize host proteases to activate the viral fusion protein, hemagglutinin, into its fusion-competent form. This presentation is composed of recent work by the Vahey Laboratory to understand the cell-type dependence of HA activation within the airway epithelium and the subcellular location(s) in which it occurs. This presentation also highlights implications and challenges for the development of broad-spectrum antivirals that target host proteases. Learning Objectives: • Understand the role of host proteases in enveloped virus entry. • Understand differences between cell subsets in the airway epithelium that influence viral infection and replication. • Understand fluorescence-based approaches to studying proteolytic activation of viral envelope proteins.https://cassyni-user-files-prod.s3.amazonaws.com/EBh4Sg5GhwxGXYcfZiQ1GJ https://cassyni.com/slides/outline/2ZTKR9nZJN4WVsA2RnpE3F https://cassyni.com/events/2ZTKR9nZJN4WVsA2RnpE3F/abstract https://cassyni-user-files-prod.s3.amazonaws.com/MbYFMiv7WfXuEZnqjqMm7t https://cassyni.com/events/2ZTKR9nZJN4WVsA2RnpE3F?videoPreview=1 Computing The Optical Response Of Molecular Materials: From Nano To Device Scalesnohttps://cassyni.com/events/2ZTKR9nZJN4WVsA2RnpE3F?videoPreview=12023-02-21T14:00:00+00:004043.12MetaMATAdvances in nanoscience and material science are accelerating the rate at which we can create new materials. But, quite often, experiments are ahead of theory due to the challenging multiscale and multidisciplinary character of the experimental systems. In my talk, I will present a novel methodology which, starting from ab initio quantum mechanical molecular simulations, allows one to compute the electromagnetic response of macroscopic photonic devices containing molecular materials.https://cassyni-user-files-prod.s3.amazonaws.com/MbYFMiv7WfXuEZnqjqMm7t https://cassyni.com/slides/outline/KqN2qT17PHWKiU6NATtdKb https://cassyni.com/events/KqN2qT17PHWKiU6NATtdKb/abstract https://cassyni-user-files-prod.s3.amazonaws.com/TrtUpmBzupgxpW7UuxNFS6 https://cassyni.com/events/KqN2qT17PHWKiU6NATtdKb?videoPreview=1 Making AI Realnohttps://cassyni.com/events/KqN2qT17PHWKiU6NATtdKb?videoPreview=12026-05-06T06:00:00+00:003622.12Business SchoolThis seminar explores the organizational shift from digital to AI-first enterprises, highlighting AI's role in advancing from data-aware to context-driven decision-making and from automation to autonomy. This transition leverages AI to democratize intelligence, necessitating a fundamental reinvention of business processes. A five-pillar strategy for AI integration is outlined: fostering an AI-first internal culture, redefining services via a human + AI autonomy model, comprehensive talent upskilling, strategic customer engagement, and robust ecosystem partnerships. Internal initiatives like hackathons and reverse mentoring cultivate this culture, demonstrating practical "bring your own AI" solutions such as procurement agents achieving 65% efficiency and personalized learning coaches. A five-level human + AI service autonomy model details AI integration, from a general tool (Level 1, ~10-15% benefits) to persona-specific assistants (Level 2, ~20-25% benefits) and agent-to-agent interactions (Level 4), with full AI autonomy (Level 5) as a long-term goal. Key adoption challenges include ensuring data platform maturity (requiring an estimated $5 investment in data for every $1 in AI), establishing outcome repeatability, and managing total cost of ownership. Organizational adoption pathways include centralized "Enterprise AI Offices," "Use Case Led", or "Discovery Led" departmental initiatives. The value journey, encompassing "Innovate with AI" (rapid prototyping in 1-3 days), "Build with AI" (integrating AI into the software development lifecycle and legacy modernization), and "Scale with AI" through agentic orchestrators like TCS AI WisdomNext, underscores the holistic investment needed across the entire "infrastructure to intelligence" value chain, from data centers to physical AI solutions.https://cassyni-user-files-prod.s3.amazonaws.com/TrtUpmBzupgxpW7UuxNFS6 https://cassyni.com/slides/outline/346vTqS5jpcZVdgv2E72JZ https://cassyni.com/events/346vTqS5jpcZVdgv2E72JZ/abstract https://cassyni-user-files-prod.s3.amazonaws.com/4HeKpj7dq8LH8Gb46rEYdc https://cassyni.com/events/346vTqS5jpcZVdgv2E72JZ?videoPreview=1 Cylinder- and Coated-cylinder-systems as Multifunctional Metamaterials: An Effective Medium Descriptionnohttps://cassyni.com/events/346vTqS5jpcZVdgv2E72JZ?videoPreview=12023-03-07T14:00:00+00:004656.08MetaMATCylinder- and coated-cylinder-based metamaterials constitute one of the most appealing metamaterial categories, especially in high frequencies, i.e. THz to optical. The effective medium descriptions though employed for the analysis of such metamaterials show serious limitations, especially in the case of high-index dielectric cylinders or cylinders made of resonant materials, such as phonon-polariton or exciton-polariton materials. In this talk we will present an effective medium approach suitable for the analysis and description of cylinder-based metamaterials, of either simple or coated/multicoated cylinders. The approach is based on the well-known to the Solid State Physics community Coherent Potential Approximation (CPA) method, combined with a Transfer Matrix scheme for the case of multi-coated cylinders. We will demonstrate here the power of this approach in the case of polaritonic cylinder systems and in systems of graphene-made nanotubes. In both cases a rich metamaterial behavior has been observed, including frequency regions of engineerable negative permittivity, negative permeability, and in some cases negative refractive index and hyperbolic response.https://cassyni-user-files-prod.s3.amazonaws.com/4HeKpj7dq8LH8Gb46rEYdc https://cassyni.com/events/DRicSC26xSEz28z43L3uz5/seminar/qa https://cassyni.com/events/DRicSC26xSEz28z43L3uz5/abstract https://cassyni-user-files-prod.s3.amazonaws.com/5Z4BkjDAhrzyz5eJjwNR82 https://cassyni.com/events/DRicSC26xSEz28z43L3uz5?videoPreview=1 Recent Advancements in MRI-based Measurements in Turbulent Flowsnohttps://cassyni.com/events/DRicSC26xSEz28z43L3uz5?videoPreview=12023-04-18T14:00:00+00:003374.08Experiments in FluidsMagnetic resonance velocimetry (MRV) is a well-known measurement method widely used for medical purposes as well as in the area of process engineering. While the boundary conditions for its application in the medical environment are governed by the need for fast measurements and are impeded by moving tissue from breathing or pulsing flow conditions, its application in process engineering is more concerned with the measurement of species concentrations, the characterization of chemical processes and small scales and/or low fluid velocities. The application of MRV for turbulent flows is a completely different field which brings high flow velocities, larger experimental setups, and turbulence into play. The further development of MRV for such applications is the main focus of our team and the presentation will review the recent advancements in this field.https://cassyni-user-files-prod.s3.amazonaws.com/5Z4BkjDAhrzyz5eJjwNR82 https://cassyni.com/events/9yBP7QVRtENLzSgVPffxTF/seminar/qa https://cassyni.com/slides/outline/9yBP7QVRtENLzSgVPffxTF https://cassyni.com/events/9yBP7QVRtENLzSgVPffxTF/abstract https://cassyni-user-files-prod.s3.amazonaws.com/SAUqoncwmRomVaSudv8eJi https://cassyni.com/events/9yBP7QVRtENLzSgVPffxTF?videoPreview=1 Home Therapies - Where is Home Haemodialysis Best Placed in Patient Timelines - how do we develop an efficient service, Incremental Peritoneal Dialysisnohttps://cassyni.com/events/9yBP7QVRtENLzSgVPffxTF?videoPreview=12023-03-10T11:30:00+00:004939.36Dialysis GroupI will be talking about our experiences of building a successful Home Haemodialysis program at the Wessex Kidney Centre in Portsmouth, and where HHD fits in the patient journey. We believe in patient choice, throughout their journey, and breaking down barriers to choice. I'll be sharing the out comes of a project that aimed to improve the information shared with patients when commencing them on incremental peritoneal dialysis. https://cassyni-user-files-prod.s3.amazonaws.com/SAUqoncwmRomVaSudv8eJi https://cassyni.com/slides/outline/ERQY8NXZUQKQ6KfxwJ4DRP https://cassyni.com/events/ERQY8NXZUQKQ6KfxwJ4DRP/abstract https://cassyni-user-files-prod.s3.amazonaws.com/7VDWmtLcpU4zWhw3GrmkDC https://cassyni.com/events/ERQY8NXZUQKQ6KfxwJ4DRP?videoPreview=1 Oncology: Circulating Markersnohttps://cassyni.com/events/ERQY8NXZUQKQ6KfxwJ4DRP?videoPreview=12022-02-15T13:00:00+00:005423.4Research Seminars by Springer NatureThis webinar focusses on 'Circulating Markers for the detection of cancer', with speakers covering a range of tumour‐derived circulating markers including circulating nucleic acids, circulating tumour cells and tumour‐educated platelets. Our panellists discuss developments in this exciting research field and their global perspectives.https://cassyni-user-files-prod.s3.amazonaws.com/7VDWmtLcpU4zWhw3GrmkDC https://cassyni.com/slides/outline/MpiG7BW91rjLPSAZepDz8u https://cassyni.com/events/MpiG7BW91rjLPSAZepDz8u/abstract https://cassyni-user-files-prod.s3.amazonaws.com/4MT2UKMaYcoNeTmfXR1hhp https://cassyni.com/events/MpiG7BW91rjLPSAZepDz8u?videoPreview=1 Mäkiharju et al.: Tomographic X-ray particle tracking velocimetrynohttps://cassyni.com/events/MpiG7BW91rjLPSAZepDz8u?videoPreview=12022-05-10T14:00:00+00:001071.96Experiments in FluidsMäkiharju et al. investigate the feasibility of in-laboratory tomographic X-ray particle tracking velocimetry (TXPTV) and consider creeping flows with nearly density matched flow tracers. Specifically, in these proof-of-concept experiments they examined a Poiseuille flow, flow through porous media and a multiphase flow with a Taylor bubble. For a full 360∘ computed tomography (CT) scan they show that the specially selected 60 micron tracer particles could be imaged in less than 3 seconds with a signal-to-noise ratio between the tracers and the fluid of 2.5, sufficient to achieve proper volumetric segmentation at each time step. In the pipe flow, continuous Lagrangian particle trajectories were obtained, after which all the standard techniques used for PTV or PIV (taken at visible wave lengths) could also be employed for TXPTV data. And, with TXPTV they can examine flows inaccessible with visible wave lengths due to opaque media or numerous refractive interfaces. In the case of opaque porous media they were able to observe material accumulation and pore clogging, and for flow with Taylor bubble they can trace the particles and hence obtain velocities in the liquid film between the wall and bubble, with thickness of liquid film itself also simultaneously obtained from the volumetric reconstruction after segmentation. While improvements in scan speed are anticipated due to continuing improvements in CT system components, they show that for the flows examined even the presently available CT systems could yield quantitative flow data with the primary limitation being the quality of available flow tracers.https://cassyni-user-files-prod.s3.amazonaws.com/4MT2UKMaYcoNeTmfXR1hhp https://cassyni.com/slides/outline/GtEDeM2tdHCJzLTDeLWzQm https://cassyni.com/events/GtEDeM2tdHCJzLTDeLWzQm/abstract https://cassyni-user-files-prod.s3.amazonaws.com/W6wVaD7uTBeQyD69i2L1in https://cassyni.com/events/GtEDeM2tdHCJzLTDeLWzQm?videoPreview=1 Project NEPTUNE: Towards exascale fusion simulations with Nektar++nohttps://cassyni.com/events/GtEDeM2tdHCJzLTDeLWzQm?videoPreview=12022-09-14T09:00:00+00:001827.4NEKTAR++The study of the anisotropic heat transport in magnetized plasma is fundamental to the stability and control of thermonuclear fusion process in tokamak reactors. Currently, tokamak is the leading candidate for a practical fusion reactor, using the magnetic confinement approach to produce controlled thermonuclear fusion power. The high-order spectral element method with highly accurate high-order elements is proven to be a promising numerical approach to accurately approximate the strong thermal anisotropy in the magnetized plasma. In this talk, extensions to NekMesh, the mesh generation tool offered as part of the Naktar++ framework, are discussed. These included methods to generate accurate high-order anisotropic meshes that incorporate domains with internal structures defined in CAD are discussed. Additional mesh control features are introduced to offer fine tuning of refinement and anisotropy directed at the internal CAD structures. These are done by utilizing techniques originally developed for aeronautical problems such as r-adaption and iso-parametric boundary layer generation. Furthermore, in order to advance Nektar++ towards the next generation of HPC and the exascale era required for feasible fusion simulations, a highly efficient matrix-free Helmholtz operator with single-instruction multiple-data (SIMD) vectorization is implemented in Nektar++. The details of the mathematical derivation and their performance are presented and compared with the matrix-based operators.https://cassyni-user-files-prod.s3.amazonaws.com/W6wVaD7uTBeQyD69i2L1in https://cassyni.com/slides/outline/KMUEsmGWpZxoMGvnC2Rd8h https://cassyni.com/events/KMUEsmGWpZxoMGvnC2Rd8h/abstract https://cassyni-user-files-prod.s3.amazonaws.com/2KAYBcSmuAjSbH3n8z9asx https://cassyni.com/events/KMUEsmGWpZxoMGvnC2Rd8h?videoPreview=1 A Modern Rigorous Approach to Stratification in NF/NFUnohttps://cassyni.com/events/KMUEsmGWpZxoMGvnC2Rd8h?videoPreview=12022-09-28T14:00:00+00:003273.76Logica UniversalisThe main feature of NF/NFU is the notion of stratification, which sets it apart from other set theories. We define stratification and prove constructively that every stratified formula has the (unique) least assignment of types. The basic notion of stratification is concerned only with variables, but we extend it to abstraction terms in order to simplify further development. We reflect on nested abstraction terms, proving that they get the expected types. These extensions enable us to check whether some complex formula is stratified without rewriting it in the basic language. We also introduce natural numbers and a variant of the axiom of infinity, in order to precisely introduce type level ordered pairs, which are crucial in simplifying the definitions in the last part of the article. Using these notions we can easily define the sets of ordinal and cardinal numbers, which we show at the end of the article. The same approach can be readily applied to NF.https://cassyni-user-files-prod.s3.amazonaws.com/2KAYBcSmuAjSbH3n8z9asx https://cassyni.com/slides/outline/5XKKad9pXkTKi6U5HM5DPs https://cassyni.com/events/5XKKad9pXkTKi6U5HM5DPs/abstract https://cassyni-user-files-prod.s3.amazonaws.com/C8Yynbv4wQhZksyaqoGHgJ https://cassyni.com/events/5XKKad9pXkTKi6U5HM5DPs?videoPreview=1 Spotlight on enhancing journal impact and reputationnohttps://cassyni.com/events/5XKKad9pXkTKi6U5HM5DPs?videoPreview=12022-11-17T09:00:00+00:001538.28Topics at the heart of our communityJoin us this November to learn about tools and concepts which may help you to enhance your journal impact and reputation. We will be looking at how the journal structure can influence the submissions a journal attracts and giving editors tools to grow the journals in key sub-disciplines. In addition, we shall discuss how author service and reproducibility can enhance reputation and drive editorial excellence. https://cassyni-user-files-prod.s3.amazonaws.com/C8Yynbv4wQhZksyaqoGHgJ https://cassyni.com/slides/outline/24n6Fqd9TYaggQAWdghFs3 https://cassyni.com/events/24n6Fqd9TYaggQAWdghFs3/abstract https://cassyni-user-files-prod.s3.amazonaws.com/T9XFUUw5zQCvFRDVExjUCv https://cassyni.com/events/24n6Fqd9TYaggQAWdghFs3?videoPreview=1 Lymphatic System Transport and Vaccine Designnohttps://cassyni.com/events/24n6Fqd9TYaggQAWdghFs3?videoPreview=12022-07-01T15:00:00+00:003458.8Journal of Fluid MechanicsAn important criterion for vaccine success is the transport of information into lymph nodes, where immune cells exist in sufficient density to facilitate adaptive immunity. This is the responsibility of the prenodal lymphatic system, which consists of porous initial lymphatics and actively pumping collecting lymphatic vessels. Antigen information can remain suspended in lymph or be captured by antigen presenting cells. Once inside the node, fluid flow and solute transport are crucial for delivering the information to specific cell types. In vivo observations of these transport processes are challenged by the lack of appropriate tools for measuring lymphatic flows. We have initiated a series of experiments and numerical simulations to investigate the roles of fluid transport in the various processes that support adaptive immunity. We have constructed porous media mathematical models for the lymph compartment, coupled to models of viscous flow in lymph node blood vessels to simulate the effects of vaccination. We have also coupled these to advection-diffusion-reaction models that simulate the migratory stimulatory effects of chemokines on immune cells. Microfluidic chamber experiments with controllable advection and ability to visualise cell migration in real time supports these models. Vaccination has strong effects on rat mesenteric collecting lymphatic pumping dynamics and fluid shifts within lymph nodes. The transport of small antigens in solution occurs primarily by diffusion in small (<1µm diameter) collagen-bundle conduit structures. These results provide insights on ways to modulate adaptive immune responses for the optimisation of vaccine design. https://cassyni-user-files-prod.s3.amazonaws.com/T9XFUUw5zQCvFRDVExjUCv https://cassyni.com/slides/outline/4Y27VFrmeqMB3Le5BNbtay https://cassyni.com/events/4Y27VFrmeqMB3Le5BNbtay/abstract https://cassyni-user-files-prod.s3.amazonaws.com/MiPbxxpKAN7USnsUKEbqyG https://cassyni.com/events/4Y27VFrmeqMB3Le5BNbtay?videoPreview=1 Turbulence modeling of strongly-coupled gas-particle flowsnohttps://cassyni.com/events/4Y27VFrmeqMB3Le5BNbtay?videoPreview=12021-04-30T15:00:00+00:001918.4Journal of Fluid MechanicsMany natural and industrial processes involve the flow of solid particles or liquid droplets whose dynamical evolution are intimately coupled with a carrier gas. A peculiar behavior of such flows is their ability to give rise to large-scale structures (hundreds to thousands of times the size of individual particles), from dense clusters to nearly-particle-free voids. Seminal works by G.K. Batchelor has provided theoretical estimates describing the motion of collections of particles suspended in viscous flows and the notion of hindered settling under gravity. In this talk I will describe how at moderate Reynolds numbers and concentrations, momentum exchange between the phases results in enhanced settling and the generation of turbulence in the carrier phase. High-resolution simulations will be presented to reveal how multiphase interactions at the particle scale augment or restrict large-scale flow processes, and provide unique insight into the budget of turbulent kinetic energy. Finally, a new data-driven framework will be presented for model closure of the averaged two-phase flow equations.https://cassyni-user-files-prod.s3.amazonaws.com/MiPbxxpKAN7USnsUKEbqyG https://cassyni.com/slides/outline/Cw3PGsrh7cmACfzYFDvwos https://cassyni.com/events/Cw3PGsrh7cmACfzYFDvwos/abstract https://cassyni-user-files-prod.s3.amazonaws.com/3epzYj6apxEYZyLz8ujRdg https://cassyni.com/events/Cw3PGsrh7cmACfzYFDvwos?videoPreview=1 Wave Excitation and Dynamics in Non-Hermitian Medianohttps://cassyni.com/events/Cw3PGsrh7cmACfzYFDvwos?videoPreview=12022-07-04T13:20:00+00:001919.04ETOPIMThe relationships between the transmission time, the total energy excited within a medium through all channels, and the density of states in open unitary systems are described in terms of the poles and zeros of the phase map of the determinant of the transmission matrix in the complex frequency plane.https://cassyni-user-files-prod.s3.amazonaws.com/3epzYj6apxEYZyLz8ujRdg https://cassyni.com/slides/outline/FQHQWJ6KJuXeZcU6nuqaXo https://cassyni.com/events/FQHQWJ6KJuXeZcU6nuqaXo/abstract https://cassyni-user-files-prod.s3.amazonaws.com/7jBEBNBfSyoMN82fLbUmdG https://cassyni.com/events/FQHQWJ6KJuXeZcU6nuqaXo?videoPreview=1 A Homogenization of Irrational Metamaterialsnohttps://cassyni.com/events/FQHQWJ6KJuXeZcU6nuqaXo?videoPreview=12022-07-06T06:30:00+00:001833.04ETOPIMFollowing the advent of electromagnetic metamaterials, researchers working in wave physics have translated concepts of engineered media to elastodynamics using analogies between Maxwell and Navier equations. Seismic metamaterials have emerged for soft soils structured at the meter scale, and have been tested ten years ago with full-scale experiments on holey soils to achieve shielding [1] and lensing [2] effects. Born in the soil, seismic metamaterials have emerged from the field of tuned-resonators buried in the soil, around building's foundations or near the soil-structure interface as local seismic isolators. Their designs are inspired e.g. by small scale mechanical metamaterials with a negative Poisson ratio, known as auxetic metamaterials [3]. Forests of trees have been interpreted as above-surface resonators, and coined natural seismic metamaterials [4]. Forest of trees not only have an effect on Rayleigh waves [4], but also on Love waves, that can be viewed as a counterpart of spoof plasmons in electromagnetics [5]. On the other hand, it is possible to control surface and volume seismic waves by structuring soft soils with columns of concrete clamped to the bedrock [6]. In this talk we will envision future developments of large scale auxetic metamaterials for building's foundations [3], above and below surface resonators for seismic protection [4, 5, 6] as well as metamaterial-like transformed urbanism at the city scale [7].https://cassyni-user-files-prod.s3.amazonaws.com/7jBEBNBfSyoMN82fLbUmdG https://cassyni.com/slides/outline/BwkBBWZeEhf1XvAY9FTczy https://cassyni.com/events/BwkBBWZeEhf1XvAY9FTczy/abstract https://cassyni-user-files-prod.s3.amazonaws.com/RVvuSkewntGysposSgjnmt https://cassyni.com/events/BwkBBWZeEhf1XvAY9FTczy?videoPreview=1 Spatial dispersion and the sign of the imaginary part of the permeabilitynohttps://cassyni.com/events/BwkBBWZeEhf1XvAY9FTczy?videoPreview=12022-07-07T15:30:00+00:001668.04ETOPIMThe modelling of the magnetic permeability is addressed in the frame of spatially dispersive media. Different situations are analyzed: i) the hydrodynamical model; ii) the spatially dispersive effective parameters of a multilayered structure; iii) the electromagnetic energy in a medium described by a spatially dispersive permittivity tensor. All these situations support that, in passive media, the imaginary part of the permeability can take positive and negative values.https://cassyni-user-files-prod.s3.amazonaws.com/RVvuSkewntGysposSgjnmt https://cassyni.com/slides/outline/NKPVGVfYrgDACuA5SvLxK7 https://cassyni.com/events/NKPVGVfYrgDACuA5SvLxK7/abstract https://cassyni-user-files-prod.s3.amazonaws.com/E7Um6QS8YWbp4k35bphbZg https://cassyni.com/events/NKPVGVfYrgDACuA5SvLxK7?videoPreview=1 Data-Driven Modelling of Aeroengine Stallnohttps://cassyni.com/events/NKPVGVfYrgDACuA5SvLxK7?videoPreview=12022-11-02T02:00:00+00:003080.92Mechanical EngineeringAccurate evaluation of stall boundary is crucial in design of aeroengines. The flow at these conditions is characterised by partial or total reversal of the flow, resulting in partial or total loss of power for the engine, leading to engine failure or shut down and can be fatal. The design of current engines is conducted by a combination of experimental testing and CFD. Engine/rig test are very expensive especially in case of failure. The increase in computing power has enabled the use large scale CFD models, but large scale CFD computations require a significant amount of computational time and cannot be used during design. In the past few years, there has been a fruitful increase in the use of Machine Learning (ML) approaches toward forecasting unsteady turbulent fluid flows. However, the ML models which are created solely from data (referred to as ‘black-box’ models) are not suitable for stall prediction due to amount of data required for training such models to a satisfactory accuracy level. Due to shortcomings of black-box models for complex science and engineering problems, there is a growing movement towards methodologies that integrate traditional physics-based models with machine learning (ML) techniques. In this presentation the application of such an approach for evaluating the stall boundary is explored.https://cassyni-user-files-prod.s3.amazonaws.com/E7Um6QS8YWbp4k35bphbZg https://cassyni.com/slides/outline/Np36KBK5J8mDCfgy3MdkaR https://cassyni.com/events/Np36KBK5J8mDCfgy3MdkaR/abstract https://cassyni-user-files-prod.s3.amazonaws.com/P5B1qqr1NNdk3WS2iTrHy8 https://cassyni.com/events/Np36KBK5J8mDCfgy3MdkaR?videoPreview=1 Ciliary Coordinationnohttps://cassyni.com/events/Np36KBK5J8mDCfgy3MdkaR?videoPreview=12020-11-20T16:00:00+00:004268.88Journal of Fluid MechanicsMotile cilia covering the surface of eukaryotic cells, from single-celled protozoa to epithelial surfaces in the mammalian airways, synchronize their beat to enable efficient fluid transport. The nature of the mechanisms leading to ciliary coordination remains unclear. I will review our understanding of this process based on physics-based mathematical models where either hydrodynamic or elastic forces between neighboring cilia are sufficient to lead to synchronization. Further, I will demonstrate that it is possible to reach, and transition between, multiple modes of synchrony by varying the intrinsic activity of the individual cilia and the strength of the coupling between them. I will conclude by commenting on the implications of these findings to our understanding of ciliary design and function in mammalian tissues as well as in unicellular organisms where transitions between distinct synchronization modes are crucial for the cell behavior and survival.https://cassyni-user-files-prod.s3.amazonaws.com/P5B1qqr1NNdk3WS2iTrHy8 https://cassyni.com/events/HNuSofCJU6g8ooSjSSdxay/abstract https://cassyni-user-files-prod.s3.amazonaws.com/ETUsJi3jqNV2DffLhwpYSa https://cassyni.com/events/YCMaCAc3dqHV4RA6xV7KT3/seminar/qa https://cassyni.com/events/YCMaCAc3dqHV4RA6xV7KT3/abstract https://cassyni-user-files-prod.s3.amazonaws.com/HnXF6jeJuJapKnR4U8mFWe https://cassyni.com/events/YCMaCAc3dqHV4RA6xV7KT3?videoPreview=1 Talking about Algebraic Geometrynohttps://cassyni.com/events/YCMaCAc3dqHV4RA6xV7KT3?videoPreview=12023-01-17T13:00:00+00:003590.76Springer Nature WebinarsIn this session Rita Pardini will interview Ciro Ciliberto who will share his view and some anecdotes related to his career, his research, his didactic and publishing activity in the area of Algebraic Geometryhttps://cassyni-user-files-prod.s3.amazonaws.com/HnXF6jeJuJapKnR4U8mFWe https://cassyni.com/slides/outline/QndWVuuB3xyyJNyCQKVgzy https://cassyni.com/events/QndWVuuB3xyyJNyCQKVgzy/abstract https://cassyni-user-files-prod.s3.amazonaws.com/7qhF8q37qJg6UkMrpxcoMQ https://cassyni.com/events/QndWVuuB3xyyJNyCQKVgzy?videoPreview=1 Re-entry vehicles for 21st century space missionsnohttps://cassyni.com/events/QndWVuuB3xyyJNyCQKVgzy?videoPreview=12018-06-08T13:00:00+00:003297.44UK Fluids NetworkEntering a planet's atmosphere from space and landing safely on its surface is a significant engineering challenge. For more than 60 years, engineers have tackled this problem; developing atmospheric entry vehicles with an impressive track record of returning cargo and humans to Earth, and even sending (unmanned) missions to land on the surface of Mars. However, as our aspirations and ambition for exploring space grow, mission requirements are evolving beyond the capabilities of existing tried-and-tested hardware and a new generation of atmospheric entry vehicles is required. In this seminar, I will present the results from an ongoing project at Imperial to tackle some of the challenges of landing humans safely on the surface of Mars. The work centres on the development of a reduced-order model to capture the unique aero-elastic behaviour of this new class of vehicle as it negotiates the re-entry environment. I will try to provide answers to the following questions: - How do we model atmospheric entry? - Why is landing humans on Mars so difficult? - What are the most promising candidate technologies for doing so? - How do we design optimal large diameter aero-decelerator heat shields? - Why do we need a coupled aero-structural solver? - Are there potential benefits from designing flexible spacecraft? My goal in this talk is not to bamboozle with equations and complex graphs, but to provide some insight into the engineering challenges of future inter-planetary exploration missions and, ultimately, explain why we believe this warrants a new approach to spacecraft design and how we are working towards this goal at Imperial.https://cassyni-user-files-prod.s3.amazonaws.com/7qhF8q37qJg6UkMrpxcoMQ https://cassyni.com/slides/outline/TFsXjL8oFFkTfKSkx1QKiu https://cassyni.com/events/TFsXjL8oFFkTfKSkx1QKiu/abstract https://cassyni-user-files-prod.s3.amazonaws.com/TgqEcbUkxCcLZiu2omgviA https://cassyni.com/events/TFsXjL8oFFkTfKSkx1QKiu?videoPreview=1 Kernel-based Statistical Methods for Functional Datanohttps://cassyni.com/events/TFsXjL8oFFkTfKSkx1QKiu?videoPreview=12021-08-14T16:00:00+00:002998.64DataSıgKernel-based statistical algorithms have found wide success in statistical machine learning in the past ten years as a non-parametric, easily computable engine for reasoning with probability measures. The main idea is to use a kernel to facilitate a mapping of probability measures, the objects of interest, into well-behaved spaces where calculations can be carried out. This methodology has found wide application, for example two-sample testing, independence testing, goodness-of-fit testing, parameter inference and MCMC thinning. Most theoretical investigations and practical applications have focused on Euclidean data. This talk will outline work that adapts the kernel-based methodology to data in an arbitrary Hilbert space which then opens the door to applications for functional data, where a single data sample is a discretely observed function, for example time series or random surfaces. Such data is becoming increasingly more prominent within the statistical community and in machine learning. Emphasis shall be given to the two-sample and goodness-of-fit testing problems.https://cassyni-user-files-prod.s3.amazonaws.com/TgqEcbUkxCcLZiu2omgviA https://cassyni.com/slides/outline/CSRQLpj45X8qMPA3wMabBB https://cassyni.com/events/CSRQLpj45X8qMPA3wMabBB/abstract https://cassyni-user-files-prod.s3.amazonaws.com/L7EahkfaWcfxtG5abXLL86 https://cassyni.com/events/CSRQLpj45X8qMPA3wMabBB?videoPreview=1 Spectroscopic studies of rare earth nitridesnohttps://cassyni.com/events/CSRQLpj45X8qMPA3wMabBB?videoPreview=12023-02-15T21:00:00+00:003554.48School of Chemical and Physical SciencesSpectroscopic tools provide one of the best ways to probe materials with complex electronic structures. The rare earth nitrides provide an especially entertaining playground to apply spectroscopy. They are mostly ferromagnetic semiconductors, with band structures that become spin-dependent as they enter the ferromagnetic phase. Their magnetism originates in the atomic-like rare earth $4f$ orbitals, although crystal field effects can lead to deviations from the usual Hund’s rule atomic ground state $4f$ configurations. They are also prone to defects such as nitrogen vacancies that introduce impurity levels that display more complex behaviour than those seen in conventional semiconductors. Here I will describe the results of optical and x-ray spectroscopy studies of various rare earth nitrides. The optical studies probe interband transitions as well as defect-to-band transitions. Evidence for intra-$4f$ transitions is somewhat inconclusive in optical spectroscopy, but x-ray magnetic circular dichroism clearly reveals the complex magnetism in the $4f$ shells. https://cassyni-user-files-prod.s3.amazonaws.com/L7EahkfaWcfxtG5abXLL86 https://cassyni.com/events/PoRAkS9nP8edfbiTo5KC4u/seminar/qa https://cassyni.com/slides/outline/PoRAkS9nP8edfbiTo5KC4u https://cassyni.com/events/PoRAkS9nP8edfbiTo5KC4u/abstract https://cassyni-user-files-prod.s3.amazonaws.com/2GQjPtaCK2UPoEYgeq8rKp https://cassyni.com/events/PoRAkS9nP8edfbiTo5KC4u?videoPreview=1 Regularization of the Hill four-body problem with oblate bodies, How many Keplerian arcs are there between two points of spacetime?nohttps://cassyni.com/events/PoRAkS9nP8edfbiTo5KC4u?videoPreview=12023-09-29T13:00:00+00:003594.92Celestial Mechanics and Dynamical AstronomyWe consider the Hill four-body problem where three oblate, massive bodies form a relative equilibrium triangular configuration, and the 4th, infinitesimal body orbits in a neighborhood of the smallest of the three massive bodies. We regularize collisions between the infinitesimal body and the smallest massive body, via McGehee coordinate transformation. We describe the corresponding collision manifold and show that it undergoes a bifurcation when the oblateness coefficient of the smallest massive body passes through the zero value. We consider the Keplerian arcs around a fixed Newtonian center joining two prescribed distinct positions in a prescribed flight time. We prove that putting aside the “opposition case” where infinitely many planes of motion are possible, there are at most two such arcs of each “type.” There is a bilinear quantity that we call b which is in all the cases a good parameter for the Keplerian arcs joining two distinct positions. The flight time satisfies a “variational” differential equation in b, and is a convex function of b.https://cassyni-user-files-prod.s3.amazonaws.com/2GQjPtaCK2UPoEYgeq8rKp https://cassyni.com/slides/outline/9VCioqDB7S3e9hLnpf8JnH https://cassyni.com/events/9VCioqDB7S3e9hLnpf8JnH/abstract https://cassyni-user-files-prod.s3.amazonaws.com/NLsLWxEeQjBMQenpVLYZUz https://cassyni.com/events/9VCioqDB7S3e9hLnpf8JnH?videoPreview=1 Induction and destruction of folding motifs in cyclotides by cyclic cystine knotsnohttps://cassyni.com/events/9VCioqDB7S3e9hLnpf8JnH?videoPreview=12024-08-22T12:00:00+00:002304.84Chemical Physics ImpactMultivariate roles of cyclic cystine knots (CCK) present in cyclotides are well known. More than often this marvellous combination of disulphide linkages embedded in a macrocyclic backbone is seen to induce and stabilize otherwise unfavourable secondary structural motifs in peptides. Partial or complete reduction of the disulphide bonds leads to significant overhauling of the peptide structure and associated dynamics with disappearance of some of the CCK-stabilized local motifs. In this work, we explore structural and dynamical intricacies in two prototypical bracelet and a Möbius cyclotide, respectively cycloviolacin O1 (cyO1), cycloviolacin O2 (cyO2) and kalata B1 (kB1), either in their native (N, with CCK), partially reduced (with either one or two S-S bonds) or completely reduced (D, without CCK) forms using molecular dynamics simulations. The S-S linkage(s) primarily responsible for sustaining a given organized motif in each case is identified from the simulation of the partially reduced forms. Correlation of helix propensity, strand propensity and hydropathicity indices of the amino acids conserved across families of different bracelet/Möbius cyclotides give insight to the natural inclination of the CCK stabilized backbones to exhibit a given motif. Dihedral principal component analysis (dPCA) and normal mode analysis (NMA) help scan through the effect of structural reorganization on peptide dynamics. The relatively restricted dynamical modes in CCK-intact native peptides are replaced with large amplitude dynamical fluctuations in the reduced peptides. Concomitant structural variance is observed across the clusters in the space spanned by the dominant principal components (PCs).https://cassyni-user-files-prod.s3.amazonaws.com/NLsLWxEeQjBMQenpVLYZUz https://cassyni.com/events/34q7SCq8DChTJ3oMSzWWih/seminar/qa https://cassyni.com/slides/outline/34q7SCq8DChTJ3oMSzWWih https://cassyni.com/events/34q7SCq8DChTJ3oMSzWWih/abstract https://cassyni-user-files-prod.s3.amazonaws.com/HbHCbCmp8B2V1qk3ri5Pb4 https://cassyni.com/events/34q7SCq8DChTJ3oMSzWWih?videoPreview=1 Electromomentum coupling via subwavelength piezoelectric asymmetriesnohttps://cassyni.com/events/34q7SCq8DChTJ3oMSzWWih?videoPreview=12024-11-12T14:00:00+00:003339.04MetaMATThe macroscopic response of acoustic metamaterials with sub-wavelength asymmetry is described with coupled constitutive relations for the acoustic pressure and momentum density. This coupling leads to momentum that is dependent on the strain rate and pressure that depends on the local acceleration. The coupled constitutive form has become known as the Willis form because they were first predicted by John Willis [Wave Motion, 3(1), 1-11, (1981)]. The subwavelength behavior of the Willis material building-blocks can be described by a polarizability matrix relating the monopole and dipole scattering moments to the local pressure and velocities fields when off-diagonal terms are non-zero [Phys. Rev. B. 96(10), 104303, (2017)], providing a metric for the design of sub-wavelength structures that produce macroscopically observable Willis coupling. More recently, Pernas-Solomon and Shmuel showed that heterogeneous piezoelectric media with subwavelength asymmetry can lead to coupling between pressure, momentum density, and electric displacement fields, a material response known as electro-momentum coupling [J. Mech. Phys. Solids, 34, 103770, (2020)]. This work will present a polarizability description of electro-momentum coupled scatterers and the means to calculate the polarizabilities that couple local pressure, velocity, and electric fields and finite element studies and experimental extraction procedures for canonical unit cells with the aim of creating metamaterials that may be tailored for improved electro-acoustic sensing.https://cassyni-user-files-prod.s3.amazonaws.com/HbHCbCmp8B2V1qk3ri5Pb4 https://cassyni.com/events/LrCVDSduR3ZSTuuCgNrug1/seminar/qa https://cassyni.com/slides/outline/LrCVDSduR3ZSTuuCgNrug1 https://cassyni.com/events/LrCVDSduR3ZSTuuCgNrug1/abstract https://cassyni-user-files-prod.s3.amazonaws.com/6FRxW5kcgt18rpuwCxaTqY https://cassyni.com/events/LrCVDSduR3ZSTuuCgNrug1?videoPreview=1 Article Teasers nohttps://cassyni.com/events/LrCVDSduR3ZSTuuCgNrug1?videoPreview=12024-11-19T15:00:00+00:003258.44Experiments in FluidsWe propose a method to obtain super-resolution of turbulent statistics for three-dimensional ensemble particle tracking velocimetry (EPTV). The method is “meshless” because it does not require the definition of a grid for computing derivatives, and it is “binless” because it does not require the definition of bins to compute local statistics. The method combines the constrained radial basis function (RBF) formalism introduced Sperotto et al. (Meas Sci Technol 33:094005, 2022) with an ensemble trick for the RBF regression of flow statistics. The computational cost for the RBF regression is alleviated using the partition of unity method (PUM). Three test cases are considered: (1) a 1D illustrative problem on a Gaussian process, (2) a 3D synthetic test case reproducing a 3D jet-like flow, and (3) an experimental dataset collected for an underwater jet flow at Re= 6750 using a four-camera 3D PTV system. For each test case, the method performances are compared to traditional binning approaches such as Gaussian weighting (Agüí and Jiménez in JFM 185:447–468, 1987), local polynomial fitting (Agüera et al. in Meas Sci Technol 27:124011, 2016), as well as binned versions of RBFs In this seminar we will present a two-color laser-induced-fluorescence (2c-LIF) technique based on a two-dye mixture, which is applied in a droplet chain of ethanol, water and ethanol/water mixtures. The technique is optimized in order to reach a high-temperature sensitivity and to avoid the detection of lasing effects in the droplets. Various droplet sizes are studied in regard to the limitation of the detection system for small micrometric droplets. The breakup of a liquid jet is analyzed to assess the technique in applications with liquid structures of different sizes. Additionally, a proposal is presented to expand the 2c-LIF application for studying ethanol/water droplets regarding mixture composition with a third color channel. Measurements in various ethanol/water mixtures are evaluated to show this possibility.https://cassyni-user-files-prod.s3.amazonaws.com/6FRxW5kcgt18rpuwCxaTqY https://cassyni.com/events/PKSWSrsXcLKvprNmE4mYPw/seminar/qa https://cassyni.com/slides/outline/PKSWSrsXcLKvprNmE4mYPw https://cassyni.com/events/PKSWSrsXcLKvprNmE4mYPw/abstract https://cassyni-user-files-prod.s3.amazonaws.com/VfZvvsPCXAM37wx4vPCz1c https://cassyni.com/events/PKSWSrsXcLKvprNmE4mYPw?videoPreview=1 Inclusive Science: Redefining Impact for Researchnohttps://cassyni.com/events/PKSWSrsXcLKvprNmE4mYPw?videoPreview=12024-11-13T15:00:00+00:003831.36Topics at the heart of our communityDid you know that up to 50% of funded research ultimately goes unpublished, and in so doing wastes billions of dollars? This includes many studies from non-Western countries, where predominantly Western editors may perceive research as lower quality or less significant. Ritu Dhand, Springer Nature’s Chief Scientific Officer, will explain how inclusive science is about understanding that research can advance discovery in ways both incremental and fundamental, and challenge the misconception that the former is less impactful or of lesser quality.https://cassyni-user-files-prod.s3.amazonaws.com/VfZvvsPCXAM37wx4vPCz1c https://cassyni.com/events/9yua5mtUMcTEnrnvpS5SsP/seminar/qa https://cassyni.com/slides/outline/9yua5mtUMcTEnrnvpS5SsP https://cassyni.com/events/9yua5mtUMcTEnrnvpS5SsP/abstract https://cassyni-user-files-prod.s3.amazonaws.com/DyqxBZwhgHbd8ptToe71Ca https://cassyni.com/events/9yua5mtUMcTEnrnvpS5SsP?videoPreview=1 Chirality as generalized spin–orbit interaction in spintronicsnohttps://cassyni.com/events/9yua5mtUMcTEnrnvpS5SsP?videoPreview=12024-11-15T12:00:00+00:004128.04Physics ReportsChirality or handedness distinguishes an object from its mirror images, such as the spread thumb, index finger, and middle finger of the right and left hand. In mathematics, it is described by the outer product of three vectors that obey a right-hand vs. lefthand rule. The chirality of ground state magnetic textures defined by the vectors of magnetization, its gradient, and an electric field from broken inversion symmetry can be fixed by a strong relativistic spin–orbit interaction. In this presentation, I focus on the chirality observed in the excited states of the magnetic order, dielectrics, and conductors that hold transverse spins when they are evanescent. Even without any relativistic effect, the transverse spin of the evanescent waves is locked to the momentum and the surface normal of their propagation plane. This chirality thereby acts as a generalized spin–orbit interaction, which leads to the discovery of various chiral interactions between magnetic, phononic, electronic, photonic, and plasmonic excitations in spintronics that mediate the excitation of quasiparticles into a single direction, leading to phenomena such as chiral spin and phonon pumping, chiral spin Seebeck, spin skin, magnonic trap, magnon Doppler, chiral magnon damping, and spin diode effects. Intriguing analogies with electric counterparts in the nano-optics and plasmonics exist. https://cassyni-user-files-prod.s3.amazonaws.com/DyqxBZwhgHbd8ptToe71Ca https://cassyni.com/events/62kMpwEAFJwp9ycVfj3B8H/seminar/qa https://cassyni.com/slides/outline/62kMpwEAFJwp9ycVfj3B8H https://cassyni.com/events/62kMpwEAFJwp9ycVfj3B8H/abstract https://cassyni-user-files-prod.s3.amazonaws.com/VWQqcU7Gi9krx5Jkevs3NN https://cassyni.com/events/62kMpwEAFJwp9ycVfj3B8H?videoPreview=1 Small micro- and nanoplastic test and reference materials for research: Current status and future needsnohttps://cassyni.com/events/62kMpwEAFJwp9ycVfj3B8H?videoPreview=12025-01-21T14:00:00+00:001905.04Cambridge PrismsEnvironmental plastic pollution comprises partially degraded particles representing a continuum of sizes, shapes, polymer types and chemical compositions. Owing to their potential for biological uptake, small microplastic particles (sMP; <100 μm) and nanoplastics (NPs) are considered to be a potential risk to organisms. Understanding how sMPs and NPs behave in the environment, and how environmental matrices affect their detection, is fundamental to quantifying exposures, assessing hazards and understanding these risks. For this purpose, highquality, well-characterised and environmentally relevant test and reference materials are crucial. The current lack of environmentally relevant sMP and NP reference materials has resulted in many studies applying commercially available spherical, homogenous and monodisperse particles, typically produced for specific purposes and without environmental relevance. There is a need for sMP and NP test/reference materials for fate and effects assessments and analytical protocol validation that more accurately represent the sMP and NP present in the environment. To date, feasible methods for producing relevant sMP and NP test materials in sufficient quantities for environmental fate and effects studies remain lacking. The current review provides an overview and comparison of the available methods, highlighting those that show the most promise for producing environmentally relevant sMP and NP with further development and optimisation.https://cassyni-user-files-prod.s3.amazonaws.com/VWQqcU7Gi9krx5Jkevs3NN https://cassyni.com/slides/outline/KruH85LrY8THoA5CaQPas7 https://cassyni.com/events/KruH85LrY8THoA5CaQPas7/abstract https://cassyni-user-files-prod.s3.amazonaws.com/MuWGYnifsgZ15ANgMhvebp https://cassyni.com/events/KruH85LrY8THoA5CaQPas7?videoPreview=1 1.3 The Technological Context: ScholComm is Formatnohttps://cassyni.com/events/KruH85LrY8THoA5CaQPas7?videoPreview=12024-11-08T17:00:00+00:002849.88Medical Library Association’s Scholarly Communications CaucusDiscuss how digital technologies have reshaped scholarly communication, research, and collaboration.https://cassyni-user-files-prod.s3.amazonaws.com/MuWGYnifsgZ15ANgMhvebp https://cassyni.com/slides/outline/AyEQHmhQdtV7cPuBAp6YY5 https://cassyni.com/events/AyEQHmhQdtV7cPuBAp6YY5/abstract https://cassyni-user-files-prod.s3.amazonaws.com/LTrXtLCBXKLZjnidTzBJwY https://cassyni.com/events/AyEQHmhQdtV7cPuBAp6YY5?videoPreview=1 Using stable isotopes in deciphering climate changes from travertine deposits: the case of the Lapis Tiburtinus succession (Acque Albule Basin, Tivoli, Central Italy)nohttps://cassyni.com/events/AyEQHmhQdtV7cPuBAp6YY5?videoPreview=12024-12-09T14:00:00+00:002125.52Frontiers in Earth ScienceQuaternary stable isotope records of marine and lacustrine carbonate deposits as well as speleothems were extensively studied to reconstruct global and regional climatic evolution. This study demonstrates how stable isotope records of travertine provide fundamental information about climate and the consequences of its evolution on groundwater level fluctuations. The deposition of the Lapis Tiburtinus travertine succession occurred during the Late Pleistocene (150–30 ka), coeval with the last activity of the Colli Albani volcanic complex. Two boreholes (Sn1 and Sn2) were drilled into the Acque Albule Basin (23 km E of Rome), crossing the entire Lapis Tiburtinus succession. The Sn1 borehole in the central part of the basin crosscuts a travertine succession of 62.1 m in thickness, while the Sn2 borehole in the southern part of the basin is characterized by a travertine succession 36.3 m in thickness. Carbon and oxygen stable isotope ratios were analysed on 118 samples (59 samples both for Sn1 and Sn2 boreholes) representative of the entire Lapis Tiburtinus travertine succession crossed by the boreholes. Values, measured and correlated in the two drilled boreholes, permitted determination of the sensitivity of the travertine depositional system to glacial and interglacial cycles, unravelling the complex oxygen and carbon cycle dynamic recorded in such sedimentary succession. Moreover, the results obtained correlated with available pollen curves of the Mediterranean area (from the Castiglione crater, 25 km E of Rome). Regional and global oxygen isotope continental and marine curves, calibrated with the stratigraphy of the Acque Albule Basin, and available U/Th dating allow the identification of at least three phases of the last interglacial (Marine Isotope Stage 5-MIS5). The carbon isotope record, compared with CO2 flux reconstructed and associated with the volcanic activity of the Colli Albani volcanic complex, instead shows an influence from groundwater level changes. In particular, positive shifts that occurred during arid phases are associated with a lower groundwater level and increased CO2 degassing, inducing a major fractionation effect on carbon isotopes. Instead, the negative shifts occurring during more humid periods indicate the inhibition of CO2 degassing and increase in pressure, attesting to a rise in groundwater level. In this view, travertine deposits, frequently studied to define the tectonic setting and activity of the area where they develop, can thus also be used as a tool to understand climate changes and groundwater variations apparent in their stable oxygen and carbon isotope signature.https://cassyni-user-files-prod.s3.amazonaws.com/LTrXtLCBXKLZjnidTzBJwY https://cassyni.com/events/Ukbn51WBqjM6mxRBSMqcGD/seminar/qa https://cassyni.com/slides/outline/Ukbn51WBqjM6mxRBSMqcGD https://cassyni.com/events/Ukbn51WBqjM6mxRBSMqcGD/abstract https://cassyni-user-files-prod.s3.amazonaws.com/JDWP47Kbv5isnF3FgyCkx6 https://cassyni.com/events/Ukbn51WBqjM6mxRBSMqcGD?videoPreview=1 Improving the Observability of Platform-Based Advertising: How the Australian Ad Observatory Helps Examine and Address(?) the Healthiness of Digital Advertisingnohttps://cassyni.com/events/Ukbn51WBqjM6mxRBSMqcGD?videoPreview=12025-01-23T02:00:00+00:003915.28Department of MarketingThe advertising ecosystem has been progressively reshaped by computational advertising models facilitated and controlled by digital media platforms. Platform advertising operated by dominant players Meta (Facebook) and Alphabet (Google) have been heavily criticised for using data generated by users on and off the platforms to heavily promote and target advertising for harmful and unhealthy products to vulnerable consumers. However the operations and impacts of these systems remain opaque and difficult to observe. The Australian Ad Observatory responds to this challenge by creating a methodological framework and research infrastructure integrating cultural, legal, media, and computational perspectives to enable the observation of computational advertising. This methodology comprises three novel computational methods: direct data gathering from ad transparency libraries; automated data donation via participatory citizen science browser plug-ins; and a privacy-aware mobile screen capture app. In this talk Prof Parker will describe how the Australian Ad Observatory works to enable scalable and participant-situated research, overcoming limitations posed by restricted platform access to computational advertising data. Prof Parker will then go on to demonstrate the potential for these methods to inform practice and policy with a brief discussion of the Ad Obsveratory's work on gambling, alcohol, greenwashing and scam research and a deep dive into the examination of unhealthy food advertisements enabled by the Australian Ad Observatory.https://cassyni-user-files-prod.s3.amazonaws.com/JDWP47Kbv5isnF3FgyCkx6 https://cassyni.com/events/TmJZyeD8xpEx7CbBLPNHTK/seminar/qa https://cassyni.com/slides/outline/TmJZyeD8xpEx7CbBLPNHTK https://cassyni.com/events/TmJZyeD8xpEx7CbBLPNHTK/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Ffd6jM5jCV8C99uB8S6Wna https://cassyni.com/events/6XRazFPa68RdySc1TqA9JV/seminar/qa https://cassyni.com/slides/outline/6XRazFPa68RdySc1TqA9JV https://cassyni.com/events/6XRazFPa68RdySc1TqA9JV/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Fh9jMfWTgLykmHQ4j2zQ9U https://cassyni.com/events/6XRazFPa68RdySc1TqA9JV?videoPreview=1 How the Membrane Got its Ripplesnohttps://cassyni.com/events/6XRazFPa68RdySc1TqA9JV?videoPreview=12024-12-12T15:00:00+00:003950.92Journal of Biological PhysicsPhase transitions of lipid membranes have drawn a lot of attention for well over 50 years. In 1973, Tardieu, Luzzati and Reman discovered the ripple phase in their X-ray diffraction experiments of single component membranes [1]. When a bilayer consisting of large head group lipids is cooled below the main phase transition temperature, it undergoes a transition to the ripple phase consisting of sawtooth-shaped ripple on the two sides of the membrane. Furthermore, the ripple is asymmetric having a major and a minor arm. The nature and molecular structure of this phase has been intensely discussed since its discovery. The typical textbook description is that the gel and fluid phases of lipid bilayers are planar and conformationally homogeneous, but in contrast to that picture, the ripple phase undulates in an asymmetric sawtooth pattern and consists of heterogeneous conformational clusters. In this talk, I discuss the properties of the ripple phase, and molecular dynamics simulations and machine learing (ML) combined with 3-body correlation functions to resolve the molecular conformations that give rise to the ripple [2]. The ML approach developed here is also applicable to various multicomponent systems, and I will discuss some of its applications.https://cassyni-user-files-prod.s3.amazonaws.com/Fh9jMfWTgLykmHQ4j2zQ9U https://cassyni.com/events/GQPfuvL4sHVxpxc2yPvWSR/abstract https://cassyni-user-files-prod.s3.amazonaws.com/CSp1hzFDSpTiuKy8z4fXq8 https://cassyni.com/events/BTudT5rpUhxwRrtgxvDWiH/seminar/qa https://cassyni.com/slides/outline/BTudT5rpUhxwRrtgxvDWiH https://cassyni.com/events/BTudT5rpUhxwRrtgxvDWiH/abstract https://cassyni-user-files-prod.s3.amazonaws.com/HAE3ZC8dUqYhDMrkT8Piir https://cassyni.com/events/BTudT5rpUhxwRrtgxvDWiH?videoPreview=1 Rising Stars in Organic Chemistry, Session 4nohttps://cassyni.com/events/BTudT5rpUhxwRrtgxvDWiH?videoPreview=12025-03-24T13:00:00+00:007460.28Thieme GroupThe Science of Synthesis Early Career Board (ECAB), established in 2022, and the Thieme Chemistry Journal Awards recognize some of the most up-and-coming young organic chemists. We are very proud to present both ECAB members and journal award winners as speakers in this Rising Stars Cheminar. In this Thieme Cheminar Science of Synthesis Early Career Advisory Board members Johannes Walker (Germany), Chun-Xiang Zhuo (China), Max Hansmann (Germany), Roly Armstrong (UK), and Marius Haugland-Grange (Norway) and Thieme Chemistry Journals Award winner Miriam O’Duill (UK) will present their research. The session is chaired by Alois Fürstner (Germany).https://cassyni-user-files-prod.s3.amazonaws.com/HAE3ZC8dUqYhDMrkT8Piir https://cassyni.com/slides/outline/8VzP4MTnSbiJWv64DQworD https://cassyni.com/events/8VzP4MTnSbiJWv64DQworD/abstract https://cassyni-user-files-prod.s3.amazonaws.com/VHQrp7vwH6eZPQTs6cE6PQ https://cassyni.com/events/16GKN6kurjQnksu9fFLBQ9/seminar/qa https://cassyni.com/slides/outline/16GKN6kurjQnksu9fFLBQ9 https://cassyni.com/events/16GKN6kurjQnksu9fFLBQ9/abstract https://cassyni-user-files-prod.s3.amazonaws.com/W14Sf9ko9cK1JHN65ZwJCE https://cassyni.com/events/16GKN6kurjQnksu9fFLBQ9?videoPreview=1 Plastic pollution and environmental education through artworknohttps://cassyni.com/events/16GKN6kurjQnksu9fFLBQ9?videoPreview=12025-07-17T13:00:00+00:001359.68Cambridge PrismsPlastics have benefited society, but their environmental impact has caused concerns since the 1970s. By the year 2050, plastic production is predicted to reach 26,000 million tonnes and generate 13,000 million tonnes of waste. Plastic in the environment impacts living organisms with short to long-term consequences. To address this, governmental policies, advocacy and recycling have been implemented with varying success. Environmental education plays an important role in mitigating some impacts of plastic pollution. Upcycling discarded plastics in artwork supports that endeavour. The art installation “Regulated Exhibition – The Plastic Human”, a collaboration between BACKLIT gallery, Joshua Sofaer and the Environment Agency, brought the artworld and environmental advocacy together, to inspire discussions on the narrative of plastic pollution. To bring the project to life BACKLIT gallery was turned into a factory where audience members could explore and interact with the installation. The exhibition was free, open to all and accessible to diverse demographics within Nottingham. The interactive exhibition provoked visitors’ senses and provided a feedback mechanism. The “Plastic Human” reflected the impacts of plastic pollution in our environment. Addressing plastic pollution is thought to cause a philosophical and/or ethical burden on humans. The measured and qualitative impact of this could impact our daily lives.https://cassyni-user-files-prod.s3.amazonaws.com/W14Sf9ko9cK1JHN65ZwJCE https://cassyni.com/events/HtLV3yGeBfAdFgb9ppbvKP/seminar/qa https://cassyni.com/slides/outline/HtLV3yGeBfAdFgb9ppbvKP https://cassyni.com/events/HtLV3yGeBfAdFgb9ppbvKP/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Eb4uCAquhxKkoWWpEqwwFC https://cassyni.com/events/HtLV3yGeBfAdFgb9ppbvKP?videoPreview=1 Digital twins for in silico clinical trials using modelling and simulationnohttps://cassyni.com/events/HtLV3yGeBfAdFgb9ppbvKP?videoPreview=12024-12-11T03:00:00+00:004053.48The Auckland Bioengineering InstituteHuman-based methodologies are at the central stage, as shown by the FDA Modernization Act 2.0, and ‘Advancing alternative methods’ (https://www.fda.gov/science-research/advancing-alternative-methods-fda/about-alternative-methods). This includes in silico techniques, such as machine learning and modelling and simulation, which are needed to analyse, integrate and augment preclinical and clinical data, to improve the understanding of phenotypic variability of human patho-physiology, and to accelerate therapy development. In this presentation, I will describe our work contributing to two key and complementary visions with powerful traction in medicine, and specifically in cardiology: Digital Twins for precision medicine (Corral-Acero et al, 2020) and In Silico Trials for therapy evaluation using virtual patient populations (Viceconti et al, 2020). I will describe how this work is powered by intersectoral collaborations, and specifically by extensive and diverse collaborations with pharma, biotech and devices industry. https://cassyni-user-files-prod.s3.amazonaws.com/Eb4uCAquhxKkoWWpEqwwFC https://cassyni.com/slides/outline/XDqoJRjp327b8ttjz3kEz9 https://cassyni.com/events/XDqoJRjp327b8ttjz3kEz9/abstract https://cassyni-user-files-prod.s3.amazonaws.com/WatkzmqE5gtb5cgiwVtLD4 https://cassyni.com/events/XDqoJRjp327b8ttjz3kEz9?videoPreview=1 Fostering Connections: Creating Engaged Editorial Boardsnohttps://cassyni.com/events/XDqoJRjp327b8ttjz3kEz9?videoPreview=12025-01-23T15:00:00+00:002055.2Topics at the heart of our communityThe backbone of any successful journal is its Editorial Board. Join us this January as we discuss how you can build connections and enhance collaboration across your editorial team. You will also get a sneak peak of our exciting new online Community dedicated to you, our network of Editors and Editorial Board Members. It's a space for connection, discussion, and empowerment.https://cassyni-user-files-prod.s3.amazonaws.com/WatkzmqE5gtb5cgiwVtLD4 https://cassyni.com/slides/outline/Dw9egW6SfzjUU28URi1siV https://cassyni.com/events/Dw9egW6SfzjUU28URi1siV/abstract https://cassyni-user-files-prod.s3.amazonaws.com/5jmrCDTvhoAEotrmECrJnJ https://cassyni.com/events/Dw9egW6SfzjUU28URi1siV?videoPreview=1 LNL Workshop: Setting Up A Student Consortium For Undergraduate Projectsnohttps://cassyni.com/events/Dw9egW6SfzjUU28URi1siV?videoPreview=12024-02-01T03:00:00+00:001081.04UKRNA consortium brings final year undergraduate students and supervisors from several institutions together to work on a shared project.  A consortium typically has around 5 supervisors from different universities, each with between 1-8 students (usually 2-5).  Kait presents her experience of setting up both mini consortia (projects shared across multiple supervisors within a university) and larger consortia (projects spanning multiple universities). https://cassyni-user-files-prod.s3.amazonaws.com/5jmrCDTvhoAEotrmECrJnJ https://cassyni.com/slides/outline/8zfcDfdCHRCT4vR8REJszM https://cassyni.com/events/8zfcDfdCHRCT4vR8REJszM/abstract https://cassyni-user-files-prod.s3.amazonaws.com/FFFjLNfn9rpVQftTMcjH1Y https://cassyni.com/events/8zfcDfdCHRCT4vR8REJszM?videoPreview=1 ORCID In Research: Beyond Identificationnohttps://cassyni.com/events/8zfcDfdCHRCT4vR8REJszM?videoPreview=12021-12-01T03:00:00+00:005750.32UKRNAn ORCID iD is a free, unique, and user-driven persistent identifier. It distinguishes researchers from every other researcher across disciplines, borders, and time. Researcher can connect their ORCID iD with their professional information—affiliations, grants, publications, peer review, and more. It can be used to share information with other systems and to ensure researchers get recognition for all their contributions.https://cassyni-user-files-prod.s3.amazonaws.com/FFFjLNfn9rpVQftTMcjH1Y https://cassyni.com/events/Pp9MioYprWjXU1puDqigV3/seminar/qa https://cassyni.com/slides/outline/Pp9MioYprWjXU1puDqigV3 https://cassyni.com/events/Pp9MioYprWjXU1puDqigV3/abstract https://cassyni-user-files-prod.s3.amazonaws.com/WVi3hqQKb4s6yGfCb77pjp https://cassyni.com/events/Pp9MioYprWjXU1puDqigV3?videoPreview=1 The late-Quaternary megafauna extinctions: Patterns, causes, ecological consequences and implications for ecosystem management in the Anthropocenenohttps://cassyni.com/events/Pp9MioYprWjXU1puDqigV3?videoPreview=12025-03-26T14:30:00+00:002049.04Cambridge PrismsAcross the last ~50,000 years (the late Quaternary) terrestrial vertebrate faunas have experienced severe losses of large species (megafauna), with most extinctions occurring in the Late Pleistocene and Early to Middle Holocene. Debate on the causes has been ongoing for over 200 years, intensifying from the 1960s onward. Here, we outline criteria that any causal hypothesis needs to account for. Importantly, this extinction event is unique relative to other Cenozoic (the last 66 million years) extinctions in its strong size bias. For example, only 11 out of 57 species of megaherbivores (body mass ≥1,000 kg) survived to the present. In addition to mammalian megafauna, certain other groups also experienced substantial extinctions, mainly large non-mammalian vertebrates and smaller but megafauna-associated taxa. Further, extinction severity and dates varied among continents, but severely affected all biomes, from the Arctic to the tropics. We synthesise the evidence for and against climatic or modern human (Homo sapiens) causation, the only existing tenable hypotheses. Our review shows that there is little support for any major influence of climate, neither in global extinction patterns nor in fine-scale spatiotemporal and mechanistic evidence. Conversely, there is strong and increasing support for human pressures as the key driver of these extinctions, with emerging evidence for an initial onset linked to pre-sapiens hominins prior to the Late Pleistocene. Subsequently, we synthesize the evidence for ecosystem consequences of megafauna extinctions and discuss the implications for conservation and restoration. A broad range of evidence indicates that the megafauna extinctions have elicited profound changes to ecosystem structure and functioning. The late-Quaternary megafauna extinctions thereby represent an early, large-scale human-driven environmental transformation, constituting a progenitor of the Anthropocene, where humans are now a major player in planetary functioning. Finally, we conclude that megafauna restoration via trophic rewilding can be expected to have positive effects on biodiversity across varied Anthropocene settings.https://cassyni-user-files-prod.s3.amazonaws.com/WVi3hqQKb4s6yGfCb77pjp https://cassyni.com/slides/outline/JsfKFy5aTwCW4v7ZDN1gku https://cassyni.com/events/JsfKFy5aTwCW4v7ZDN1gku/abstract https://cassyni-user-files-prod.s3.amazonaws.com/YTvCPfx7aWK3sRPLm3bRxS https://cassyni.com/events/JsfKFy5aTwCW4v7ZDN1gku?videoPreview=1 Are Compact Cities a Solution to Sustainability? Lessons From an Urban Morphological Analysis of Calgary and Zurichnohttps://cassyni.com/events/JsfKFy5aTwCW4v7ZDN1gku?videoPreview=12025-03-10T22:00:00+00:002773.12The University of Auckland Business SchoolUrban sprawl presents significant challenges, including economic inefficiencies, public health burdens, and environmental degradation. Compact city development offers a viable solution by fostering economic resilience, improving public health outcomes—reducing the need for costly healthcare services—and lowering carbon footprints, which translates to financial savings at both municipal and individual levels. This seminar will explore these benefits through a comparative analysis of Calgary and Zurich, examining how their urban forms and policies shape development outcomes. While Zurich exemplifies dense, transit-oriented growth, Calgary's expansive layout and car-dependent infrastructure pose barriers to achieving similar efficiencies. A key method for assessing and guiding urban change is morphological analysis, which allows us to evaluate parcel sizes, building types, back alleys, and street widths to identify redevelopment opportunities. By understanding these spatial patterns, cities can better design policies that encourage sustainable, human-scaled development. Finally, effective public engagement is crucial in shaping livable communities. Case studies from Chinatown and Canmore demonstrate how participatory urban design fosters inclusive decision-making. Insights from urban design studios further illustrate the tools necessary for meaningful community involvement. This seminar bridges research and practice, equipping participants with the analytical and engagement strategies needed for shaping sustainable, inclusive, and equitable cities, as stated in the UN’s SDG 8. https://cassyni-user-files-prod.s3.amazonaws.com/YTvCPfx7aWK3sRPLm3bRxS https://cassyni.com/events/VFH1EKfbgYpvbRQhETxaSR/seminar/qa https://cassyni.com/slides/outline/VFH1EKfbgYpvbRQhETxaSR https://cassyni.com/events/VFH1EKfbgYpvbRQhETxaSR/abstract https://cassyni-user-files-prod.s3.amazonaws.com/TFWUqF3LFBx9qn6nNypvo8 https://cassyni.com/events/VFH1EKfbgYpvbRQhETxaSR?videoPreview=1 Design-Build-Fly: A behind the scenes look at the development and flight test of the worlds first hybrid-electric Ultra-Short Takeoff and Landing Aircraft and the pathway to sustainable aviation.nohttps://cassyni.com/events/VFH1EKfbgYpvbRQhETxaSR?videoPreview=12025-02-04T12:00:00+00:002974.68Brahmal Vasudevan Institute for Sustainable AviationThis seminar will be given by JP Stewart, the Senior VP of Product Development at Electra. Electra is pioneering electric aviation, having recently successfully tested a new electric aircraft design capable of taking off in just 150 feet. JP will discuss the technical challenges faced in developing truly sustainable aircraft, as well as some of the future directions for electric aviation.https://cassyni-user-files-prod.s3.amazonaws.com/TFWUqF3LFBx9qn6nNypvo8 https://cassyni.com/events/53WPxpxtB7h2RjerJgfH25/seminar/qa https://cassyni.com/slides/outline/53WPxpxtB7h2RjerJgfH25 https://cassyni.com/events/53WPxpxtB7h2RjerJgfH25/abstract https://cassyni-user-files-prod.s3.amazonaws.com/DbgBdKCyN5MuL1ztkDB4SS https://cassyni.com/events/53WPxpxtB7h2RjerJgfH25?videoPreview=1 16th international Biometals Webinarsnohttps://cassyni.com/events/53WPxpxtB7h2RjerJgfH25?videoPreview=12025-06-03T13:00:00+00:005764.92BioMetalsThe mammalian blood plasma is critical for the distribution of essential metal ions throughout the body. Plasma zinc constitutes a very small but rapidly exchangeing pool. The speciation of exchangeable zinc in mammalian blood plasma is dominated by serum albumin. This protein is present at a concentration of ca. 600 micromolar, and has an affinity for Zn2+ in the high nanomolar range. Another important set of metalbolites transported by albumin are non-esterified fatty acids (NEFAs). We have previously discovered that Zn2+ and NEFA binding are allosterically coupled, with NEFAs decreasing the zinc binding ability of albumin. Hence, NEFAs affect plasma zinc speciation, with higher NEWFA levels leading to displacement of Zn2+ from albumin. Plasma NEFA levels are dynamic, with elevations observed after fasting and in stress situations, but they can also be chronically elevated as a consequence of disease states including type II diabetes. This allosteric crosstalk likely has an array of consequences on several physiological processes, including hemostasis, insulin activity and clearance, and zinc export from plasma. Our studies indicate that the understanding of copper transport is incomplete without the explicit consideration of kinetics of Cu2+ ion binding and exchange reactions. The kinetic data should be interpreted in the context of time constraints imposed by specific physiological processes. Examples from experimental studies will be used to support the role of reaction intermediates exhibiting lifetimes between 100 ms and 10 s as physiological effectors. This emerging idea will be discussed in the context of other areas of metallomics.https://cassyni-user-files-prod.s3.amazonaws.com/DbgBdKCyN5MuL1ztkDB4SS https://cassyni.com/slides/outline/7WkRCFCWNQTWng8QrNZuk1 https://cassyni.com/events/7WkRCFCWNQTWng8QrNZuk1/abstract https://cassyni-user-files-prod.s3.amazonaws.com/GKvUGejaRdHypV2unURs3L https://cassyni.com/events/7WkRCFCWNQTWng8QrNZuk1?videoPreview=1 High-order Implicit Shock Tracking for High-speed Flowsnohttps://cassyni.com/events/7WkRCFCWNQTWng8QrNZuk1?videoPreview=12024-12-05T12:00:00+00:001847.28JKW Symposium TeamShock tracking or shock fitting, where the computational mesh is moved to align mesh element faces with discontinuities, represents them perfectly with the inter-element jump in the solution basis without requiring additional stabilization when addressing shocks. In our previous work, we introduced an implicit shock tracking framework that discretizes conservation laws on a mesh without knowledge of discontinuities and solves a PDE-constrained optimization problem over the discrete solution variables and nodal coordinates of the mesh. A Discontinuous Galerkin (DG) discretization of the governing equation is applied and implicit tracking is formulated as an optimization problem constrained by the DG residual to endow the method with desirable properties of DG: consistency, conservation, and stability. The optimization problem is solved using a sequential quadratic programming method that simultaneously converges the mesh and flow solution to their optimal values. In this talk, we present a $p$-adaptive implicit shock tracking method aimed at solving steady and unsteady high-speed viscous flows. The polynomial degree is adapted used an indicator based on the enriched residual, which tends to increase the polynomial degree within shocks and boundary layers. A series of shock-dominated numerical experiments demonstrate the potential of the method to efficiently produce accurate solutions to these challenging problems.https://cassyni-user-files-prod.s3.amazonaws.com/GKvUGejaRdHypV2unURs3L https://cassyni.com/slides/outline/44DBsTfqJCaskyprCiBxDB https://cassyni.com/events/44DBsTfqJCaskyprCiBxDB/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Lh74QSXFmMKbZobsGiTCxW https://cassyni.com/events/44DBsTfqJCaskyprCiBxDB?videoPreview=1 Update on JetZero's BWBnohttps://cassyni.com/events/44DBsTfqJCaskyprCiBxDB?videoPreview=12024-12-07T17:00:00+00:001664.96JKW Symposium TeamNo abstracthttps://cassyni-user-files-prod.s3.amazonaws.com/Lh74QSXFmMKbZobsGiTCxW https://cassyni.com/events/ERpsqpFrWpDJHV7zDp8qth/abstract https://cassyni-user-files-prod.s3.amazonaws.com/EfM3L3GRQg8oLFP5X51MNE https://cassyni.com/slides/outline/EvUUtVuNxGmMHFespFReA1 https://cassyni.com/events/EvUUtVuNxGmMHFespFReA1/abstract https://cassyni-user-files-prod.s3.amazonaws.com/8gtg2xzgfr8CWX3Z8dBpX8 https://cassyni.com/events/EvUUtVuNxGmMHFespFReA1?videoPreview=1 Iron deficiency anemia in patients with heavy menstrual bleeding: The patients’ perspective from diagnosis to treatmentnohttps://cassyni.com/events/EvUUtVuNxGmMHFespFReA1?videoPreview=12025-05-15T18:00:00+00:00639.56Women's HealthBackground: Heavy menstrual bleeding (HMB) associated with iron deficiency anemia (IDA) negatively affects quality of life (QoL). Management of IDA usually begins with oral iron supplementation or, if ineffective/poorly tolerated, then intravenous iron (IVI) is given; however, no guidance exists on transitioning from oral to IVI in patients with HMB. While various IVI products exist, safety profiles and distinct properties affecting treatment logistics make product choice important. Objectives: Assess the IVI treatment journey for patients with HMB and IDA. Design: A survey was designed to assess multiple aspects of IVI treatment to evaluate patient perspectives. Methods: Patients (⩾18 years) from the United States with IDA currently prescribed IVI completed a survey conducted by The Harris Poll in 2023. Questions covered symptoms, time to diagnosis/treatment, IVI appointment logistics, IVI infusion experience, impact on daily activities, and patient preferences. Results: Of 323 respondents, 71 (22.0%) were prescribed IVI for HMB and received ⩾2 IVI infusions monthly. The mean age for these patients was 33.5 years; they experienced a mean of 2.9 years from symptom onset until IDA diagnosis, and 1.4 years between diagnosis and IVI treatment. Most patients agreed that navigating IVI treatment logistics interfered with productivity and social commitments, and felt they must schedule their life around treatment. Patients who were also diagnosed with hypophosphatemia following IVI (12/71; 16.9%) reported a mean of 8.2 additional hospital visits. Furthermore, 36.6% of patients missed an IVI dose; of these, 80.8% preferred single-dose IVI. Conclusion: Patients with IDA and HMB experienced substantial delays from symptom onset to subsequent IVI treatment, demonstrating a gap in management. Therefore, oral iron may not be an appropriate first-line treatment for some of these patients. Multiple-dose IVI and associated appointment logistics can negatively impact patients’ perspectives on treatment. Single-dose IVI preferences should be considered to improve patients’ adherence and QoL.https://cassyni-user-files-prod.s3.amazonaws.com/8gtg2xzgfr8CWX3Z8dBpX8 https://cassyni.com/events/MqaZehUcW3SrvYLrUFw1wK/seminar/qa https://cassyni.com/slides/outline/MqaZehUcW3SrvYLrUFw1wK https://cassyni.com/events/MqaZehUcW3SrvYLrUFw1wK/abstract https://cassyni-user-files-prod.s3.amazonaws.com/3uGKNCautVhHT8X4TFUy3t https://cassyni.com/events/MqaZehUcW3SrvYLrUFw1wK?videoPreview=1 Analyzing the propagation of elastic waves in space-time modulated media through multiple scattering and mode coupling theorynohttps://cassyni.com/events/MqaZehUcW3SrvYLrUFw1wK?videoPreview=12025-05-06T13:00:00+00:003690.64MetaMATIn this talk, we analyze the propagation and scattering of elastic waves in bounded spatiotemporally modulated elastic media. The first part introduces an analytical framework based on multiple scattering theory (MST) to model finite-size elastic metamaterials under space-time modulation. Specifically, we examine the dynamics of elastic waveguides equipped with time-modulated resonators. Leveraging the flexibility of MST, our approach accommodates arbitrary distributions of resonators with distinct space-time modulation profiles, enabling the computation of the wavefield both within and beyond the resonators' region. The second part presents a theoretical framework based on mode coupling theory to describe wave scattering across a finite-duration spatiotemporal modulation. Our approach enables the investigation of temporal scattering phenomena associated with subsonic and supersonic regimes, highlighting and quantifying the occurrence of nonreciprocal wave conversion and parametric amplification. The proposed methodologies enhance the understanding and development of time-varying elastic materials, unlocking new possibilities for designing one-way elastic filters, amplifiers, and frequency converters. https://cassyni-user-files-prod.s3.amazonaws.com/3uGKNCautVhHT8X4TFUy3t https://cassyni.com/slides/outline/FR9i3p4no6FB6iePcMYcLD https://cassyni.com/events/FR9i3p4no6FB6iePcMYcLD/abstract https://cassyni-user-files-prod.s3.amazonaws.com/G36eecaXykUNH6WMp1oGR4 https://cassyni.com/events/FR9i3p4no6FB6iePcMYcLD?videoPreview=1 The Microbiota Vaultnohttps://cassyni.com/events/FR9i3p4no6FB6iePcMYcLD?videoPreview=12025-09-09T12:30:00+00:00874.2Microbiome Virtual International ForumIndustrialization and urbanization are eroding human-associated microbial diversity, contributing to rising immune and metabolic disorders. The Microbiota Vault initiative, modeled after the Seed Vault, offers an equitable global framework to preserve this biodiversity by enabling local capacity, standardized protocols, and secure backup storage. Through the Global Microbiota Network (GloMiNe), pilot repositories, and international outreach, the project connects biodiversity-rich but resource-limited regions with global efforts. These activities lay the foundation for a distributed infrastructure to safeguard microbial heritage for science, health, and future generationshttps://cassyni-user-files-prod.s3.amazonaws.com/G36eecaXykUNH6WMp1oGR4 https://cassyni.com/events/Gu6XBs1N7TuqXSdWTnE2DB/abstract https://cassyni-user-files-prod.s3.amazonaws.com/8TrxWBKzCuAYoLyAFZDCAi https://cassyni.com/slides/outline/NpTS2d3NLYf7Pq8zKsiP3j https://cassyni.com/events/NpTS2d3NLYf7Pq8zKsiP3j/abstract https://cassyni-user-files-prod.s3.amazonaws.com/FrCNRV3fkkqZjWCqm761sc https://cassyni.com/events/NpTS2d3NLYf7Pq8zKsiP3j?videoPreview=1 The Microbiota Vault's equitable biobanking frameworknohttps://cassyni.com/events/NpTS2d3NLYf7Pq8zKsiP3j?videoPreview=12025-05-05T12:30:00+00:00556.04Microbiome Virtual International ForumDrawing inspiration from the Svalbard Global Seed Vault, the Microbiota Vault represents a global initiative to safeguard microbiomes across human, animal, and environmental domains. Operating as a non-profit charity, the Microbiota Vault, acts at the request and on behalf of sovereign depositors worldwide, who have local working collections, to preserve backup copies of specimens of human or environmental origin. Depositors retain full control over the specimens they deposit in the Microbiota Vault. Upon explicit request by the depositing collections, sequence annotation of deposited materials will be provided and included in open-access databases. Making the annotated samples visible aims at creating a catalog of microbial diversity and empowers local working collections by connecting them to global research efforts. We will discuss our experiences when setting up this biobanking framework and how it relates to the principles of access and benefit sharing and to developments with respect to Digital Sequence Information. https://cassyni-user-files-prod.s3.amazonaws.com/FrCNRV3fkkqZjWCqm761sc https://cassyni.com/slides/outline/KNLYRHEzJkgKtP751U8ew7 https://cassyni.com/events/KNLYRHEzJkgKtP751U8ew7/abstract https://cassyni-user-files-prod.s3.amazonaws.com/3ts7prbP9R3bezE9dEPbMG https://cassyni.com/events/KNLYRHEzJkgKtP751U8ew7?videoPreview=1 Unlocking the Power of Research Seminars, Amplifying Research Impact Through Scholarly Videonohttps://cassyni.com/events/KNLYRHEzJkgKtP751U8ew7?videoPreview=12025-04-07T20:30:00+00:002651.04Research Analytics SummitWith over 1 million research seminars held globally each year, these events offer invaluable opportunities to explore new findings, discuss publications, and foster collaboration. As researchers increasingly turn to video to share their work, many struggle to find platforms that properly capture, present, and maximize the academic value of their research. Fragmented and inefficient systems often leave this critical activity disconnected from the scholarly record. Tailored scholarly video platforms enable researchers to embed their seminar content into the scholarly record, making it more discoverable, accessible, and impactful. These platforms deliver measurable benefits, such as doubling citation rates for associated papers. Institutions adopting such tools have become hubs for global research communities, driving successful grant collaborations, student recruitment, and deeper engagement with external stakeholders. New analytics now provide insights into the reach, engagement, and impact of seminars, enabling researchers and institutions to showcase value to funders and stakeholders. Join us to explore how scholarly video platforms are transforming research seminars into enduring assets that amplify research impact, foster collaboration, and strengthen the global research ecosystem.https://cassyni-user-files-prod.s3.amazonaws.com/3ts7prbP9R3bezE9dEPbMG https://cassyni.com/events/XiYeaNR7HCXBn4LsyphP5F/abstract https://cassyni-user-files-prod.s3.amazonaws.com/VpuLkk4SBx79Xq5YbsSoU2 https://cassyni.com/events/SHR14rJLTAS7PC6eNuhb5o/seminar/qa https://cassyni.com/slides/outline/SHR14rJLTAS7PC6eNuhb5o https://cassyni.com/events/SHR14rJLTAS7PC6eNuhb5o/abstract https://cassyni-user-files-prod.s3.amazonaws.com/MHS5PaDJFzufzJS4uPcMn6 https://cassyni.com/events/SHR14rJLTAS7PC6eNuhb5o?videoPreview=1 Towards hybrid CFD - ML: Combining modern high order methods and reinforcement learningnohttps://cassyni.com/events/SHR14rJLTAS7PC6eNuhb5o?videoPreview=12026-02-09T13:00:00+00:003938.16Sci-Fi-TurboMultiscale and multiphysics problems are typically governed by a wide range of interacting temporal and spatial scales, with different physical processes often dominating the opposing ends of the scale range. The simulation of these phenomena requires highly accurate and efficient numerical schemes that should allow for adaptive and flexible discretization strategies to tailor the approximation scheme to the locally dominating physical effect. Still, for practical applications, the occurring scale range in relevant engineering applications typically remains too immense even for well-parallelized simulations on nascent exascale architectures. Here, scale-bridging models must supplement upscaled governing equations to enable simulations of for example turbulent flows, flows with phase interfaces and so on. In this talk, I will present contributions and recent advances to both fields: First, I will discuss highly accurate and locally adaptive numerical schemes based on DGSEM for solving the compressible Navier-Stokes equations on exascale systems and beyond with a focus on applications in the aerospace engineering sector. In the second part of my talk, I will discuss how and where machine learning methods, in particular reinforcement learning, can help devise the necessary scale bridging models that are numerically and mathematically consistent and provide examples of successful CFD/ML hybrid applications. https://cassyni-user-files-prod.s3.amazonaws.com/MHS5PaDJFzufzJS4uPcMn6 https://cassyni.com/events/TGHsSms6HfeMrUtnEXUxCD/seminar/qa https://cassyni.com/slides/outline/TGHsSms6HfeMrUtnEXUxCD https://cassyni.com/events/TGHsSms6HfeMrUtnEXUxCD/abstract https://cassyni-user-files-prod.s3.amazonaws.com/GqynVBjboGGro4sXMHUiCe https://cassyni.com/events/TGHsSms6HfeMrUtnEXUxCD?videoPreview=1 The Nocturnists: Storytelling in Medicine as a Vehicle for Personal Transformation and Systems Changenohttps://cassyni.com/events/TGHsSms6HfeMrUtnEXUxCD?videoPreview=12025-12-11T21:00:00+00:003630.04Family MedicineObjectives/Guiding Questions: * Discuss the history, work, and mission of national award-winning healthcare storytelling organization, The Nocturnists. * Reflect on how telling your own personal story might lead to greater connection with patients, increased capacity to find meaning in your work, and restored humanity in a system that can be dehumanizing. * Articulate how sharing personal stories in community can begin to transform the structures, attitudes, and cultural norms that inhibit authentic healing within our current healthcare system.https://cassyni-user-files-prod.s3.amazonaws.com/GqynVBjboGGro4sXMHUiCe https://cassyni.com/events/811Je7ddAp3V5trHKDteW1/seminar/qa https://cassyni.com/slides/outline/811Je7ddAp3V5trHKDteW1 https://cassyni.com/events/811Je7ddAp3V5trHKDteW1/abstract https://cassyni-user-files-prod.s3.amazonaws.com/FxZtP7MdiMqWkJrkwgeLHU https://cassyni.com/events/811Je7ddAp3V5trHKDteW1?videoPreview=1 Malonates as anti-prostrate cancer agentsnohttps://cassyni.com/events/811Je7ddAp3V5trHKDteW1?videoPreview=12025-06-20T08:15:00+00:00886.04Anti-Cancer Agents in Medicinal ChemistryNo abstracthttps://cassyni-user-files-prod.s3.amazonaws.com/FxZtP7MdiMqWkJrkwgeLHU https://cassyni.com/slides/outline/9ybiprDiveGFBc8WgBkavZ https://cassyni.com/events/9ybiprDiveGFBc8WgBkavZ/abstract https://cassyni-user-files-prod.s3.amazonaws.com/KR5Rv3ANvTpVJoAvGWMLXQ https://cassyni.com/events/9ybiprDiveGFBc8WgBkavZ?videoPreview=1 History Matters: Remembering Why the Present and Future of Science and Metascience Require Knowledge of Their Pastnohttps://cassyni.com/events/9ybiprDiveGFBc8WgBkavZ?videoPreview=12025-06-19T14:00:00+00:005196.6Helping scholars learn from prior studies has taken on special urgency as they seek to publicize their work faster than institutions can curate it and AI tools offer easy, unsourced answers. To address this challenge, metascientists need to study the history of metascience. In this virtual symposium, early-, mid-, and advanced-career researchers from computer science, statistics, psychiatry, and bioinformatics will discuss how we can learn from the past to build knowledge infrastructure for the future. The program will consist of 5 segments, each starting with a 3-minute history lesson followed by a 9-minute discussion addressing a prompt. 1. Plato's epistemology and Aristotle's ontology formed the foundations of European scholarly thought. Has the scientific community integrated their best ideas, or have we forgotten important lessons from ancient Greece? 1. Library catalogues have evolved dramatically since Antonio Panizzi’s Rules for the Compilation of the Catalogue of 1841. How can human-curated catalogues complement search engines and recommendation algorithms? 1. Vannevar Bush's 1945 essay “As We May Think”, proposed “memex”, an automated system for managing information stored on microfilm. Have we already achieved Bush's vision? What challenges did he not foresee? 1. Thinkers of the 2000s envisioned the semantic web, where automated agents would answer questions using distributed, machine-readable knowledge. Have innovations brought this ideal closer to reality or rendered it irrelevant? 1. The Gene Ontology Knowledge Base has become a cornerstone of bioinformatics. What lessons can institutions and alliances learn from this success to create cross-disciplinary networks of knowledge repositories?https://cassyni-user-files-prod.s3.amazonaws.com/KR5Rv3ANvTpVJoAvGWMLXQ https://cassyni.com/events/2Zsf8bWrLmxQh2c3iJtrWZ/seminar/qa https://cassyni.com/slides/outline/2Zsf8bWrLmxQh2c3iJtrWZ https://cassyni.com/events/2Zsf8bWrLmxQh2c3iJtrWZ/abstract https://cassyni-user-files-prod.s3.amazonaws.com/BwYG3Y66GmKukcGZDyWM8r https://cassyni.com/events/2Zsf8bWrLmxQh2c3iJtrWZ?videoPreview=1 Academic Writing and How to Publish with Impact in Water Research Xnohttps://cassyni.com/events/2Zsf8bWrLmxQh2c3iJtrWZ?videoPreview=12025-06-12T08:00:00+00:004875.76ElsevierThis webinar marks the launch of the Water Research X (WRX) webinar series. Prof. Zhiguo Yuan will present how to write an impactful academic paper. Drawing on his experience as a leading researcher and journal editor, Prof. Yuan will share practical advice on structuring, framing, and refining research for publication. He will introduce the editorial standards of WRX and explain the differences between its two article types: Research Articles and Research Letters. The session will also introduce the aims and schedule of the WRX webinar series, designed to foster global impact in water science and engineering.https://cassyni-user-files-prod.s3.amazonaws.com/BwYG3Y66GmKukcGZDyWM8r https://cassyni.com/events/CSqk4GTM7w2jYYc5DsfDeV/abstract https://cassyni-user-files-prod.s3.amazonaws.com/24adxRmJfDSpxTEqTc8eFx https://cassyni.com/events/3ZCVLbKnd3zHWG8T6rJcx5/seminar/qa https://cassyni.com/slides/outline/3ZCVLbKnd3zHWG8T6rJcx5 https://cassyni.com/events/3ZCVLbKnd3zHWG8T6rJcx5/abstract https://cassyni-user-files-prod.s3.amazonaws.com/6T9GCrdAMy2EE21qJG7F66 https://cassyni.com/events/3ZCVLbKnd3zHWG8T6rJcx5?videoPreview=1 Kinetic theory of moderately dense dry granular particles under a simple shearnohttps://cassyni.com/events/3ZCVLbKnd3zHWG8T6rJcx5?videoPreview=12025-07-16T12:00:00+00:003317.28Granular MatterWe formulate the kinetic theory of dry granular particles under a simple shear based on the Enskog and Grad approximations [1,2]. We get a complete set of equations for the kinetic stress and the collisional contribution to the stress within this approximation. The steady solution under this approximation reproduces quantitatively accurate results for the shear viscosity and kinetic temperature for volume fractions φ<0.5, except in nearly elastic situations. We also obtain qualitatively accurate results for the steady normal stress differences for φ<0.5. By using a protocol that reverses a shear rate satisfying Newton's equation of motion, we also discuss the relaxation dynamics required to reach the steady state. We have also observed the Mpemba effect if the initial conditions of two copied systems are not largely deviated References: [1] H. Hayakawa and S. Takada, Nonlinear rheology: Non-equilibrium statistical physics of granular materials (Springer) in press. [2] S. Iizuka, S. Takada, and H. Hayakawa, in preparation.https://cassyni-user-files-prod.s3.amazonaws.com/6T9GCrdAMy2EE21qJG7F66 https://cassyni.com/slides/outline/AxvZ2r2fCvJ7zqev4jAMN5 https://cassyni.com/events/AxvZ2r2fCvJ7zqev4jAMN5/abstract https://cassyni-user-files-prod.s3.amazonaws.com/QSdFUhYgy2y7tC5QwMkzEr https://cassyni.com/events/AxvZ2r2fCvJ7zqev4jAMN5?videoPreview=1 Voices from the Margins: Lived Experiences of Inequalitynohttps://cassyni.com/events/AxvZ2r2fCvJ7zqev4jAMN5?videoPreview=12025-07-13T23:00:00+00:004608.32SACL This study examines the lived economic experiences of CAs (SA) who qualified after 2016 and were educated entirely during the democratic era. Through in-depth interviews, the study examines how mechanisms of social closure and cumulative inequality shape access to the CA profession and influence the career trajectories of aspirants. The findings highlight the multifaceted costs — both explicit and hidden — incurred throughout the CA qualification journey, revealing how these reinforce existing social inequalities and constrain social mobility. By centring participant narratives, this study provides nuanced insights into the persistent struggles faced by aspiring accountants from diverse socio-economic backgrounds and calls for policy and structural reforms to foster a more equitable professional landscape in South Africa.https://cassyni-user-files-prod.s3.amazonaws.com/QSdFUhYgy2y7tC5QwMkzEr https://cassyni.com/events/MLZs7q8ZptrGfpeTNQ3ggD/abstract https://cassyni-user-files-prod.s3.amazonaws.com/4QDVrvubyY7t4MvVLQs2pv https://cassyni.com/events/9xY4Uve3cw4db2zW7uD97b/abstract https://cassyni-user-files-prod.s3.amazonaws.com/UF11tQLZiG4hSQBeFFbE86 https://cassyni.com/events/9xY4Uve3cw4db2zW7uD97b?videoPreview=1 Best Practices in Research Metricsnohttps://cassyni.com/events/9xY4Uve3cw4db2zW7uD97b?videoPreview=12020-10-14T08:00:00+00:003135.24 School of Public PolicyAbstract not yet added.https://cassyni-user-files-prod.s3.amazonaws.com/UF11tQLZiG4hSQBeFFbE86 https://cassyni.com/events/3Y8pzfk7KLnfugzSYZmB97/seminar/qa https://cassyni.com/slides/outline/3Y8pzfk7KLnfugzSYZmB97 https://cassyni.com/events/3Y8pzfk7KLnfugzSYZmB97/abstract https://cassyni-user-files-prod.s3.amazonaws.com/VUz7FeiHkeVq33C7pDJQRk https://cassyni.com/events/3Y8pzfk7KLnfugzSYZmB97?videoPreview=1 Embedding Sustainability in BioMEMS and Microfluidic Manufacturing for Point-of-care Diagnosticsnohttps://cassyni.com/events/3Y8pzfk7KLnfugzSYZmB97?videoPreview=12026-01-07T15:00:00+00:003142.16UK Microsystems NetworkMicrofluidic and BioMEMS systems underpin the rapid growth of point-of-care diagnostics, enabling miniaturised, portable, and cost-effective solutions that bring testing closer to patients. However, the very success of these technologies, which are often single-use and disposable, poses a challenge: how can we scale production responsibly while reducing environmental impact? This talk will address sustainability in Microfluidic and BioMEMS manufacturing, focusing on barriers and opportunities to align innovation with global environmental goals. As well as discussing ‘hidden’ environmental issues in the industry, I will share examples from my research to illustrate how sustainable solutions can be hide unexpected innovation. Beyond technical solutions, I will discuss the role of intersectoral collaboration—between engineers, manufacturers, and policymakers—in shaping a diagnostics industry that is both resilient and environmentally conscious.https://cassyni-user-files-prod.s3.amazonaws.com/VUz7FeiHkeVq33C7pDJQRk https://cassyni.com/events/XCUHhaVPJLiyw56KHWswEM/seminar/qa https://cassyni.com/slides/outline/XCUHhaVPJLiyw56KHWswEM https://cassyni.com/events/XCUHhaVPJLiyw56KHWswEM/abstract https://cassyni-user-files-prod.s3.amazonaws.com/G4v1Tj6fXfkyjn9HNdiq1Q https://cassyni.com/events/XCUHhaVPJLiyw56KHWswEM?videoPreview=1 Scientific hypothesis generation by large language models: laboratory validation in breast cancer treatmentnohttps://cassyni.com/events/XCUHhaVPJLiyw56KHWswEM?videoPreview=12025-11-26T11:00:00+00:001520.0Royal Society PublishingLarge language models (LLMs) have transformed artificial intelligence (AI) and achieved breakthrough performance on a wide range of tasks. In science, the most interesting application of LLMs is for hypothesis formation. A feature of LLMs, which results from their probabilistic structure, is that the output text is not necessarily a valid inference from the training text. These are termed ‘hallucinations’, and are harmful in many applications. In science, some hallucinations may be useful: novel hypotheses whose validity may be tested by laboratory experiments. Here, we experimentally test the application of LLMs as a source of scientific hypotheses using the domain of breast cancer treatment. We applied the LLM GPT4 to hypothesize novel synergistic pairs of US Food and Drug Administration (FDA)-approved non-cancer drugs that target the MCF7 breast cancer cell line relative to the non-tumorigenic breast cell line MCF10A. In the first round of laboratory experiments, GPT4 succeeded in discovering three drug combinations (out of 12 tested) with synergy scores above the positive controls. GPT4 then generated new combinations based on its initial results, this generated three more combinations with positive synergy scores (out of four tested). We conclude that LLMs are a valuable source of scientific hypotheses.https://cassyni-user-files-prod.s3.amazonaws.com/G4v1Tj6fXfkyjn9HNdiq1Q https://cassyni.com/slides/outline/Tjw4NnxiE8rLuNnkdrVyhX https://cassyni.com/events/Tjw4NnxiE8rLuNnkdrVyhX/abstract https://cassyni-user-files-prod.s3.amazonaws.com/AtYvuchuLSQ5EfEY71EN3p https://cassyni.com/events/Tjw4NnxiE8rLuNnkdrVyhX?videoPreview=1 Planta Medica: Most Innovative Paper Award nohttps://cassyni.com/events/Tjw4NnxiE8rLuNnkdrVyhX?videoPreview=12025-10-28T12:00:00+00:002689.76Thieme BioSciencesCongratulations are in order as Planta Medica’s 2024 Most Innovative Paper Award goes to Patricia Frei, Christian Nadegger, Angelika M. Vollmar, Thomas Müller, and Simone Moser for their studies on Phylloxanthobilins in Tropaeolum majus. In the 1st edition of our brand-new Thieme Bioscience Seminar series, Dr. Simone Moser (University of Innsbruck, Austria) will present her award-winning research in this area and its significance in phytomedicine. The seminar is chaired by Prof. Robert Fürst (LMU Munich, Germany). Don’t miss out on the opportunity to gain exclusive and up-to-date insights into the relevance of phylloxanthobilins and sign up today! https://cassyni-user-files-prod.s3.amazonaws.com/AtYvuchuLSQ5EfEY71EN3p https://cassyni.com/events/BSY7rEcPk2aLE36GGPMCxV/seminar/qa https://cassyni.com/slides/outline/BSY7rEcPk2aLE36GGPMCxV https://cassyni.com/events/BSY7rEcPk2aLE36GGPMCxV/abstract https://cassyni-user-files-prod.s3.amazonaws.com/195YssA9CsaefnMbpfCsY https://cassyni.com/events/BSY7rEcPk2aLE36GGPMCxV?videoPreview=1 How many plasmids can bacteria carry? A synthetic biology perspectivenohttps://cassyni.com/events/BSY7rEcPk2aLE36GGPMCxV?videoPreview=12025-12-04T09:00:00+00:002837.12Royal Society PublishingPlasmids are pinnacle tools in synthetic biology and other biotechnological applications. They serve as the simplest approach to introduce recombinant DNA, which is then transcribed into RNA that functions as is or is translated into a protein of interest. Despite their widespread utility, the question ‘how many plasmids can be used in this bacterium?’ remains underexplored in the existing literature. In this article, I discuss the maintenance of multiple unique plasmids in bacteria through a microbial synthetic biology perspective, both in theoretical and practical aspects. I delve into the existing evidence of multi-plasmid systems, aiming to pinpoint the possible maximum number of unique plasmids a single microbe can carry. Finally, I highlight how the existing applications of multi-plasmid systems drive novel discovery and development in metabolic engineering, synthetic biology and other relevant areas in comparison to other non-plasmid strategies.https://cassyni-user-files-prod.s3.amazonaws.com/195YssA9CsaefnMbpfCsY https://cassyni.com/events/Pnmr7xJQ7qLvGC2UXJrNjF/abstract https://cassyni-user-files-prod.s3.amazonaws.com/KPdAxS4aFi55eyez6KS3Bk https://cassyni.com/slides/outline/JMeCcSBdHoFqsKnEvPrajo https://cassyni.com/events/JMeCcSBdHoFqsKnEvPrajo/abstract https://cassyni-user-files-prod.s3.amazonaws.com/o2UyeKBEvt4EeayDdUinr https://cassyni.com/events/JMeCcSBdHoFqsKnEvPrajo?videoPreview=1 The pace of life: effects of circadian clock speed on plant growth and developmentnohttps://cassyni.com/events/JMeCcSBdHoFqsKnEvPrajo?videoPreview=12025-08-07T09:00:00+00:00978.72NoneEndogenous circadian rhythms underpin plant growth and development and confer growth benefits when aligned with environmental rhythms. Despite a constant 24-hour period of daily rhythms in the environment, natural variation exists in plant circadian clock speed. Recent evidence suggests that variation in clock speed might be an adaptation to daily variations in light intensity. We evaluated whether variation in clock speed influences relative utilization of daily light exposure by subjecting plants to time-restricted photosynthesis. By restricting photosynthetic growth to either the first or second half of the day, we observed a linear relationship between clock speed and relative utilization of daily light exposure. These findings provide novel insights into how plant circadian oscillators regulate growth and provide opportunities for fine-tuning controlled-environment growth conditions to optimize radiation use efficiency.https://cassyni-user-files-prod.s3.amazonaws.com/o2UyeKBEvt4EeayDdUinr https://cassyni.com/events/VDuVdURAwsSKPbcGXw6Ggd/seminar/qa https://cassyni.com/slides/outline/VDuVdURAwsSKPbcGXw6Ggd https://cassyni.com/events/VDuVdURAwsSKPbcGXw6Ggd/abstract https://cassyni-user-files-prod.s3.amazonaws.com/BbBdoRN9YMX573tzBMpWE2 https://cassyni.com/events/VDuVdURAwsSKPbcGXw6Ggd?videoPreview=1 Onsager’s "ideal turbulence" theorynohttps://cassyni.com/events/VDuVdURAwsSKPbcGXw6Ggd?videoPreview=12025-11-06T16:00:00+00:003912.16Journal of Fluid MechanicsLars Onsager made an exact analysis of the high-Reynolds-number limit for individual turbulent flow realisations modelled by incompressible Navier–Stokes equations, motivated by experimental observations that dissipation of kinetic energy does not vanish in turbulent wakes. I review here developments spurred by his key idea that such flows are well described by distributional or "coarse-grained" solutions of ideal Euler equations. 1/3 Hölder singularities of the velocity field were predicted by Onsager and since observed. His theory describes turbulent energy cascade local-in-scale without probabilistic assumptions and yields a space-time local, deterministic version of the Kolmogorov 4/5th law. It is now rigorously proved that the dissipative Euler solutions conjectured by Onsager do exist and, surprisingly, are non-unique for fixed, deterministic initial data. Such non-unicity is consistent with ``spontaneously stochastic'' turbulent dynamics. After concisely reviewing these developments, we discuss more recent work applying Onsager's theory to turbulent fluid interactions with solid boundaries via inertial spatial cascades of momentum and vorticity. We will emphasize some crucial questions for further experimental and numerical investigation. https://cassyni-user-files-prod.s3.amazonaws.com/BbBdoRN9YMX573tzBMpWE2 https://cassyni.com/events/UEcHY7884xLAiqnGRxcwsj/seminar/qa https://cassyni.com/slides/outline/UEcHY7884xLAiqnGRxcwsj https://cassyni.com/events/UEcHY7884xLAiqnGRxcwsj/abstract https://cassyni-user-files-prod.s3.amazonaws.com/JX1TS5AKgr51VJBXmTXtzz https://cassyni.com/events/UEcHY7884xLAiqnGRxcwsj?videoPreview=1 Thieme Cheminar: Small Molecules in Medicinal Chemistrynohttps://cassyni.com/events/UEcHY7884xLAiqnGRxcwsj?videoPreview=12025-12-10T16:00:00+00:005501.6Thieme GroupThis seminar addresses advances in small molecules within medicinal chemistry, emphasizing sustainable synthetic methodologies and targeted therapeutic development. The first presentation detailed strategies for ring expansion of three-membered N-heterocycles, such as aziridines and epoxides, to access bioactive compounds including γ-lactams, pyrrolines, and sulfonylazetidines. Employing asymmetric organocatalysis, photocatalysis, and flow chemistry, the work demonstrated efficient, diastereo- and enantioselective syntheses with applications to natural product analogs and drug-like molecules. Notably, a novel one-pot procedure enabled the conversion of aziridines to γ-lactams with up to 78% yield, and photocatalytic flow methods facilitated the preparation of pyrrolines and pyrroles under mild conditions. The second presentation focused on the development of conformationally restricted dipeptide-like small molecules targeting protein kinase C (PKC) isoforms implicated in cancer, particularly hedgehog pathway-dependent tumors. A phenotypic screening platform identified potent PKC modulators that inhibit hedgehog signaling, overcoming resistance to existing Smoothened inhibitors. Synthetic efforts yielded scalable routes to indolactam-based macrocycles and analogs, enabling structure-activity relationship studies that achieved single-digit nanomolar potency and demonstrated in vivo efficacy in basal cell carcinoma models. Integration of biological assays, medicinal chemistry, and synthetic innovation underscored the potential of these small molecules as novel therapeutics. The seminar highlighted challenges in solvent selection for sustainability, photocatalyst choice guided by substrate absorption, and the role of artificial intelligence in catalyst and drug design, illustrating the interplay between synthetic methodology and medicinal applications in advancing small molecule drug discovery.https://cassyni-user-files-prod.s3.amazonaws.com/JX1TS5AKgr51VJBXmTXtzz https://cassyni.com/events/528tMyiTSSJRDurRc9nyGH/seminar/qa https://cassyni.com/slides/outline/528tMyiTSSJRDurRc9nyGH https://cassyni.com/events/528tMyiTSSJRDurRc9nyGH/abstract https://cassyni-user-files-prod.s3.amazonaws.com/99qYpA3KPG1ZejFVL1Hj6v https://cassyni.com/events/528tMyiTSSJRDurRc9nyGH?videoPreview=1 A micro-to-macroscale and multi-method investigation of human sweating dynamicsnohttps://cassyni.com/events/528tMyiTSSJRDurRc9nyGH?videoPreview=12025-11-19T17:30:00+00:004362.52Royal Society PublishingSweat secretion and evaporation from the skin dictate the human ability to thermoregulate and thermal comfort in hot environments and impact skin interactions with cosmetics, textiles and wearable electronics/sensors. However, sweating has mostly been investigated using macroscopic physiological methods, leaving micro-to-macroscale sweating dynamics unexplored. We explore these processes by using a coupled micro-imaging and transport measurement approach used in engineering studies of phase change processes. Specifically, we used a comprehensive set of ‘macroscale’ physiological measurements (ventilated capsule sweat rate (SR), galvanic skin conductance and dielectric epidermis hydration) complemented by three microscale imaging techniques (visible light, midwave infrared and optical coherence tomography imaging). Inspired by industrial jet cooling devices, we also explore an ‘air jet’ (versus cylindrical) capsule for measuring SR. To enable near-simultaneous application of these methods, we studied forehead sweating dynamics of six supine subjects undergoing passive heating, cooling and secondary heating. The relative dynamics of the physiological measurements agree with prior observations and can be explained using imaged microscale sweating dynamics. This comprehensive study provides new insights into the biophysical dynamics of sweating onset and following cyclic porewise, transition and filmwise sweating modes and highlights the roles of stratum corneum hydration, salt deposits and microscale hair.https://cassyni-user-files-prod.s3.amazonaws.com/99qYpA3KPG1ZejFVL1Hj6v https://cassyni.com/events/PK8fBwCnBN8wDJ8W7yqMDw/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Rishh51YsxVSjWJT57WWAS https://cassyni.com/events/KLy2pRzZa5HigZJeJwGMBK/seminar/qa https://cassyni.com/slides/outline/KLy2pRzZa5HigZJeJwGMBK https://cassyni.com/events/KLy2pRzZa5HigZJeJwGMBK/abstract https://cassyni-user-files-prod.s3.amazonaws.com/NEdFnwP4LCm4jPXogSD8wQ https://cassyni.com/events/KLy2pRzZa5HigZJeJwGMBK?videoPreview=1 Making Choices: A Multi-institutional, Longitudinal Cohort Study Assessing Changes in Treatment Outcome Valuation for Low-risk Thyroid Cancernohttps://cassyni.com/events/KLy2pRzZa5HigZJeJwGMBK?videoPreview=12026-09-17T18:00:00+00:003415.04Center for Cancer TrainingBackground: Overuse of total thyroidectomy (TT) for low-risk thyroid cancer is common. Patient preference for TT is often influenced by strong negative emotions that result from a cancer diagnosis. The objective of this study was to evaluate the relative importance of treatment outcomes to patients with low-risk thyroid cancer to inform the development of interventions that better align patients' choices with outcomes they value most. Methods: Adults with clinically low-risk thyroid cancer enrolled in a prospective, multi-institutional, longitudinal cohort study from November 2019 to June 2021. To assess the relative importance and change in importance of outcomes over time, participants rated treatment outcomes at the time of their surgical decision and again 9 months later by allocating 100 points among 10 possible outcomes. The outcomes fell within 5 domains defined a priori as cancer-related, emotion-related, quality of life, logistical, and surgical complications. t-tests and Hotelling T-squared statistic compared outcome valuation within and between subjects based on chosen extent of surgery (TT vs hemi-thyroidectomy). Results: Of 177 eligible patients, 125 participated (70.6% response) and 114 completed the 9-month follow-up (91.2% retention). At the time of the treatment decision, participants choosing TT valued the risk of recurrence more than those choosing hemi-thyroidectomy and the need to take thyroid hormone to replace thyroid function less than those who selected hemi-thyroidectomy (p<0.05). At repeat valuation 9 months later, the importance of the risk of recurrence decreased for those choosing TT, but increased for those who chose hemi-thyroidectomy (p<0.05). Analysis of the entire cohort at 9 months showed that participants weighed the importance of emotion-related outcomes and having the cancer removed less than at initial valuation and the impact of treatment on quality of life, voice, and energy levels more (p<0.05). Conclusions: The relative importance of treatment outcomes changes for patients with low-risk TC once the outcome has been experienced to favor quality of life over emotion-related outcomes. Clinicians can use this information to highlight effects of treatment on quality of life and discuss the potential for fatigue or changes in energy levels associated with removing the entire thyroid with TT.https://cassyni-user-files-prod.s3.amazonaws.com/NEdFnwP4LCm4jPXogSD8wQ https://cassyni.com/slides/outline/FuQbVgVubVq9PwNG5CsM6D https://cassyni.com/events/FuQbVgVubVq9PwNG5CsM6D/abstract https://cassyni-user-files-prod.s3.amazonaws.com/DByGJGwZb8ccaaggSFQfc2 https://cassyni.com/events/FuQbVgVubVq9PwNG5CsM6D?videoPreview=1 Expect the Unexpected – Digital Enterprise Planning in the 2020’snohttps://cassyni.com/events/FuQbVgVubVq9PwNG5CsM6D?videoPreview=12023-03-24T00:00:00+00:003660.4Business SchoolThis abstract explores the challenges and approaches to digital enterprise planning in a dynamic environment, drawing on the experiences of Foodstuffs North Island, a large-scale retailer with 3.5 million customers weekly and 24,000 employees. Facing disruptions such as the pandemic, cost-of-living crises, and severe weather events, the organisation prioritises becoming a customer-driven retailer. Its strategic framework integrates customer context, internal analysis, and customer promises across banners (price, solution, experience), supported by five strategic pillars. The technology strategy focuses on digital experience, data-powered operations, cost optimisation, workforce development, and enhanced security and resilience. To manage "always-on disruption," an in-year replanning methodology delineates executive focus on outcomes and non-negotiables from leadership’s role in resource allocation and cross-functional prioritisation, supported by a value stream concept for demand-supply alignment. A key example of crisis management involved leveraging Starlink technology during Cyclone Gabrielle. Following an initial deployment for mobile EFTPOS in three communities, the technology team rapidly developed a "hackathon-style" solution to fully enable store networks in 7-8 communities in Hawke's Bay, restoring critical operations 48-72 hours faster than traditional methods. This success was attributed to prior investments in common network standards, documentation, skilled personnel, and a problem-solving cultural mindset, demonstrating that challenges can strengthen organisational resilience.https://cassyni-user-files-prod.s3.amazonaws.com/DByGJGwZb8ccaaggSFQfc2 https://cassyni.com/events/Skh6WghS9wbZB8q7Gp85bK/seminar/qa https://cassyni.com/slides/outline/Skh6WghS9wbZB8q7Gp85bK https://cassyni.com/events/Skh6WghS9wbZB8q7Gp85bK/abstract https://cassyni-user-files-prod.s3.amazonaws.com/RrNLMXiWGduS4AV5J4gq5G https://cassyni.com/events/Skh6WghS9wbZB8q7Gp85bK?videoPreview=1 Distribution of regularized three-body phase-volume , Characterization of asteroid shapes and stability on their surface using super-ellipsoids nohttps://cassyni.com/events/Skh6WghS9wbZB8q7Gp85bK?videoPreview=12026-02-13T14:00:00+00:004175.08Celestial Mechanics and Dynamical AstronomyThis seminar presents two distinct studies in celestial mechanics. The first investigates the distribution of regularized three-body phase-volume, essential for statistically predicting decay times in non-hierarchical three-body systems. The problem is reformulated into a three-degree-of-freedom triangle geometry space, applying a flux-based statistical theory. Divergence is addressed by a regularization method that subtracts a reference phase volume of asymptotically straight escape pipes. Analytical integrations enable numerical computation over S^3 (3D) or S^2 (2D). Results confirm accuracy for escape probabilities and demonstrate that σ̄(E,L) is positive, decreases with mass contrast, and approaches zero in limiting cases. The second study characterizes asteroid shapes and surface stability using super-ellipsoids, generalizing triaxial ellipsoids with exponent `n`. A Dynamically Equivalent Equal-Mass Super-Ellipsoid (DEEMSE) method minimizes surface deviation for optimal fitting. Application to bodies reveals best fits for Bennu and Ryugu as top-shapes (n ≈ 1.6), Vesta and Ceres as nearly ellipsoidal (n ≈ 2), and Eros as a rounded-corner orthohedron (n ≈ 2.5), improving characterization over standard ellipsoids. Surface stability on spinning super-ellipsoids is analyzed through derived detachment limits and slope angles. For fast rotations, top-shaped bodies exhibit more stable surfaces than ellipsoids. A parametric analysis of Didymos' primary suggests top-shaped configurations (n = 1.6–1.8) are more likely for stable surfaces consistent with dimensional estimates, implying a stable, nearly ellipsoidal Didymos is improbable.https://cassyni-user-files-prod.s3.amazonaws.com/RrNLMXiWGduS4AV5J4gq5G https://cassyni.com/slides/outline/Ht2do3btkgyde8Ltijfj9P https://cassyni.com/events/Ht2do3btkgyde8Ltijfj9P/abstract https://cassyni-user-files-prod.s3.amazonaws.com/EQbLNXZneLqW1XCgjDGGNi https://cassyni.com/events/Ht2do3btkgyde8Ltijfj9P?videoPreview=1 Strong light-matter interaction in 2D magnetsnohttps://cassyni.com/events/Ht2do3btkgyde8Ltijfj9P?videoPreview=12025-06-16T07:00:00+00:001312.24ETOPIMvan der Waals (vdW) magnets that host excitons that show a strong correlation to underlying magnetic order present a unique opportunity to realize strong interaction between magnons, excitons and photons. Furthermore, these systems facilitate the optical control of electronic and spin degrees of freedom. In this talk, I will discuss our work on magnetic semiconductor, CrSBr where in the bulk limit, the excitons are inherently dressed by photons forming self-hybridized exciton-polaritons [1]. The signature of coherent magnon oscillations imprinted on the polaritons and the potential to modify magneto-optical response by tuning the photon fraction of the polariton states will be discussed. Following this I will present our recent work on the role of magnons on nonlinear exciton-exciton interaction in CrSBr [2]. Finally, time permitting, I will discuss confinement and propagation of magneto-exciton polaritons.https://cassyni-user-files-prod.s3.amazonaws.com/EQbLNXZneLqW1XCgjDGGNi https://cassyni.com/slides/outline/UkHvp5qSQmA7AQAvLGuR6D https://cassyni.com/events/UkHvp5qSQmA7AQAvLGuR6D/abstract https://cassyni-user-files-prod.s3.amazonaws.com/EnqSPZJctpCngRoPxGVwDY https://cassyni.com/events/UkHvp5qSQmA7AQAvLGuR6D?videoPreview=1 Pathways to Carbon Circularity through Biomass Conversion and Plastic Waste Upcyclingnohttps://cassyni.com/events/UkHvp5qSQmA7AQAvLGuR6D?videoPreview=12025-07-10T09:00:00+00:004062.04Thieme India ChemTalksThe conversion of biomass into chemicals is considered a key driver for the next generation of industrial development. Producing functional chemicals from biomass holds significant industrial relevance. In this talk, Dr. Gupta will discuss pathways for the production of chemicals such as amines and aromatics, with a focus on their synthesis from bio-derived sugars. Key Takeaways for the Audience: * Insight into how complex biomass and plastic can be effectively valorized for chemical production, including an overview of current approaches and existing bottlenecks. * Exploration of different conversion routes for transforming biomass-derived intermediates into valuable amines. * Discussion on how catalytic pathways can be strategically designed to produce aromatic compounds from renewable biomass sources. * Future directions for developing scalable and economically viable biomass/plastic-to-chemicals technologies.https://cassyni-user-files-prod.s3.amazonaws.com/EnqSPZJctpCngRoPxGVwDY https://cassyni.com/slides/outline/XDXx3W54c3vbXLeUsxp3p9 https://cassyni.com/events/XDXx3W54c3vbXLeUsxp3p9/abstract https://cassyni-user-files-prod.s3.amazonaws.com/8jjBErxD2Gmzj3Vghxp7QA https://cassyni.com/events/XDXx3W54c3vbXLeUsxp3p9?videoPreview=1 Tunable asymmetric responses via multilayers of Babinet patternsnohttps://cassyni.com/events/XDXx3W54c3vbXLeUsxp3p9?videoPreview=12025-06-19T23:00:00+00:001197.16ETOPIMMetamaterials constructed with plasmonic nanoresonator arrays of specific symmetry properties can result in asymmetric optical responses. Nonreciprocal phenomena include asymmetric cross-polarized reflection (ARcross) and transmission (ATcross) in Tellegen materials and asymmetric co-polarized transmission (ATco) in artificial moving media [1]. In our previous studies we presented multilayers constructed with consecutive periodic patterns of Babinet complementary miniarrays of spherical plasmonic nanoresonators that exhibit asymmetric optical responses [2, 3]. Comparison of tri-layers proved that all optical responses are larger for the cx-cv-cx multilayer in both inspected azimuthal orientations, except the copolarized reflectance, and X azimuthal orientation is more preferable. The (i) NIM, (ii) asymmetric transmission, (iii) asymmetric polarization rotation is accompanied by magnetic dipoles with precession trajectory is of (i) large amplitude, small ellipticity and tilting (ii) small amplitude, large ellipticity and intermediate tilting, (iii) intermediate amplitude and ellipticity, large out-of-plane tilting. The cx-cv-cx multilayer possesses better Tellegen coupling (artificial moving) characteristics compared to the cv-cx-cv layer, based on the larger ATcross and ARcross (ATco), Tellegen parameter, and larger cumulated polarization rotation (∑=(f-f)+(b-b)), despite the predominantly larger detuning between AT and ∑ maxima. The original multilayers exhibit considerable ∑ in the interval of Tellegen parameters’ modulation (at 750 nm /705 nm for cx-cv-cx in the 0° /90° azimuthal orientation). Optimization performed to reach ∑~90°, by illuminating the multilayer with p-polarized light from backward, in the azimuthal orientation corresponding to the outgoing polarization orientation achieved in case of forward illumination (b:= f), resulted in appearance of generalized Faraday rotation phenomenon in the interval of vanishing transmission of the multilayers. Both the maximal ∑ and it’s spectral location were tunable by varying the coupling between the constituent layers. Optimization of nonreciprocity originating from magnetic field emulation via controlled out-of-plane tilted magnetic dipole generation is in progress, by setting criteria on the residual optical signals.https://cassyni-user-files-prod.s3.amazonaws.com/8jjBErxD2Gmzj3Vghxp7QA https://cassyni.com/slides/outline/71mLn1NM6cnhMetdxBWkPo https://cassyni.com/events/71mLn1NM6cnhMetdxBWkPo/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Wfoc6pC7NiutqZJ4Xej9Gz https://cassyni.com/events/71mLn1NM6cnhMetdxBWkPo?videoPreview=1 Ancient alliances with global consequences: the functional significance of Mucoromycotina ‘fine root endophytes’nohttps://cassyni.com/events/71mLn1NM6cnhMetdxBWkPo?videoPreview=12025-07-10T12:00:00+00:001778.56NoneFossil evidence from the Rhynie Chert reveals that the earliest land plants, which evolved under high atmospheric CO₂ during the Paleozoic Era, hosted a diverse array of fungal symbionts. These symbioses likely played a foundational role in the transformation of Earth’s atmosphere, contributing to the drawdown of CO₂ and the rise of oxygen that set the stage for complex terrestrial life, including mammals and humans. However, a major gap remains in our understanding of how the nutrient acquisition strategies of these early plants shaped global biogeochemical cycles and climate. Recent advances in experimental work now challenge previous assumptions about the identity and function of early mycorrhizal fungi. Our research has demonstrated that Mucoromycotina ‘fine root endophytes’ (MFRE), long understudied and misidentified, are widespread and form nutritional symbioses with a range of plant lineages. By developing monoxenic in vitro cultures of MFRE isolated from a lycophyte and successfully colonising a flowering plant (_Trifolium_), we show MFRE fungi transferred both phosphorus (33P) and nitrogen (15N) to the host in return for plant-fixed carbon. Further experimentation has defined environmental responsiveness and a physiological niche for plant-MFRE symbioses, helping to explain their co-existence alongside other widespread symbiotic soil fungi. Integrating these experimental results with climate-biosphere modelling, we demonstrate that symbiotic fungal identity critically modulates plant productivity and carbon-for-nutrient exchange with important implications for global biogeochemical cycles. Our findings underscore the evolutionary and ecological importance of diverse mycorrhizas in shaping terrestrial ecosystems and highlight the need for a revised understanding of mycorrhizal diversity in both modern and ancient contexts, with implications for reconstructing Earth’s deep-time and projected future climate trajectory. https://cassyni-user-files-prod.s3.amazonaws.com/Wfoc6pC7NiutqZJ4Xej9Gz https://cassyni.com/slides/outline/43uLcY15sEPt9Rab6dFm3B https://cassyni.com/events/43uLcY15sEPt9Rab6dFm3B/abstract https://cassyni-user-files-prod.s3.amazonaws.com/KEXhC1d4iv6J6zHKgYfH3k https://cassyni.com/events/43uLcY15sEPt9Rab6dFm3B?videoPreview=1 Serial Risk Sharingnohttps://cassyni.com/events/43uLcY15sEPt9Rab6dFm3B?videoPreview=12025-07-06T01:00:00+00:001209.48Risk SciencesTo allocate the total cost of producing goods demanded by multiple agents, Moulin and Shenker (1992, Econometrica 60(5), 1009-1037) introduced the serial cost sharing method. This approach decomposes the quantities demanded by agents into incremental parts and assigns the associated production costs evenly among the relevant agents claiming each increment. Inspired by this framework, we propose a novel serial risk-sharing mechanism tailored for heterogeneous losses. The mechanism decomposes individual losses into parts, each of which has the same distribution as the corresponding parts of other agents. The identically distributed parts are then shared uniformly among the relevant agents. The primary motivation is to achieve equitable risk sharing by averaging identically distributed losses. This rule simplifies significantly when the initial losses are ordered in the first-order stochastic dominance. We examine properties of this rule and compare it to the conditional mean risk sharing (CMRS) method. While CMRS boasts a straightforward structure and appealing theoretical properties, its practical implementation is often impeded by the computational challenges of estimating conditional means. In contrast, the serial risk-sharing mechanism provides closed-form formulas for risk allocations, circumventing the need for conditional distributions and offering a computationally efficient alternative to CMRS. This speech record is from Tim's keynote speech for [2025 International Workshop on Risk Sharing (IWRS) ](https://www.keaipublishing.com/en/journals/risk-sciences/event/2025-international-workshop-on-risk-sharing-iwrs/) , to be held on July 6-7, 2025, in Beijing, China. [Risk Sciences ](https://www.keaipublishing.com/en/journals/risk-sciences/) aims to foster diverse, multidisciplinary insights in risk sciences, bridging theory and practice through a series of academic activities. This talk is part of the "Research Insights" track of this series, presenting cutting-edge findings and methodologies, offering valuable perspectives to researchers and practitioners alike.https://cassyni-user-files-prod.s3.amazonaws.com/KEXhC1d4iv6J6zHKgYfH3k https://cassyni.com/slides/outline/DR5HoiAih8wGcjJ4mZb6eR https://cassyni.com/events/DR5HoiAih8wGcjJ4mZb6eR/abstract https://cassyni-user-files-prod.s3.amazonaws.com/H6Uep68W2otcrk2Mt7BGvr https://cassyni.com/events/DR5HoiAih8wGcjJ4mZb6eR?videoPreview=1 Are Consumers Ready to Embrace Green Energy?nohttps://cassyni.com/events/DR5HoiAih8wGcjJ4mZb6eR?videoPreview=12023-03-16T09:00:00+00:002258.48 School of Public PolicyThis study investigates household willingness to adopt key electrification technologies—electric vehicles (EVs), heat pumps, and rooftop solar—in Georgia, a state with significant climate vulnerability yet slow consumer uptake of green energy solutions. Employing a survey of 1,800 households and analytical frameworks grounded in the Theory of Diffusion of Innovation and the Theory of Planned Behavior, the research examines socio-demographic, psychological, and infrastructural factors influencing adoption decisions. A Heckman two-step model assesses both the initial willingness to consider adoption and the subsequent willingness to pay, revealing that limited knowledge, political affiliation (notably Republican identification), lack of climate concern, and absence of a sustainable lifestyle significantly reduce adoption likelihood. Infrastructure constraints, such as insufficient charging stations and fossil fuel heating systems, further impede uptake. Income strongly affects rooftop solar adoption and co-adoption of multiple technologies, underscoring the need for inclusive financing mechanisms. Motivations differ by technology: environmental concerns primarily drive solar adoption, economic savings motivate heat pump uptake, and EV adoption reflects a mix of both. Policy incentives notably increase willingness to adopt heat pumps and solar, highlighting the critical role of supportive regulatory frameworks. The findings emphasize the importance of integrated technology adoption strategies and the promotion of climate-smart lifestyles to overcome the “one solution bias.” The study calls for expanded research across diverse geographies to account for place-specific socio-technical dynamics and to inform tailored policy interventions facilitating accelerated clean energy transitions at the household level.https://cassyni-user-files-prod.s3.amazonaws.com/H6Uep68W2otcrk2Mt7BGvr https://cassyni.com/slides/outline/CRn5iLsfpDq7wyU4fb7mqX https://cassyni.com/events/CRn5iLsfpDq7wyU4fb7mqX/abstract https://cassyni-user-files-prod.s3.amazonaws.com/WCaoTVsQzz5CZQh5jFBUhL https://cassyni.com/events/CRn5iLsfpDq7wyU4fb7mqX?videoPreview=1 Risk Sharing and Negative Dependencenohttps://cassyni.com/events/CRn5iLsfpDq7wyU4fb7mqX?videoPreview=12025-07-06T01:00:00+00:001545.64Risk Sciences[***Risk Sciences***](https://www.keaipublishing.com/en/journals/risk-sciences/) aims to foster diverse, multidisciplinary insights in risk sciences, bridging theory and practice through a series of academic activities. Professor Wang's research interests mainly lie in quantitative risk management, which includes various topics in actuarial science, financial engineering, operations research, probability, statistics, and economic theory This speech record is an excerpt from Professor Wang's keynote speech for the [Risk Sciences Colloquium – 2025 International Workshop on Risk Sharing (IWRS)](https://www.keaipublishing.com/en/journals/risk-sciences/event/2025-international-workshop-on-risk-sharing-iwrs/), which was held on July 6-7, 2025, in Beijing, China. This video is categorized under ***General Theory***.https://cassyni-user-files-prod.s3.amazonaws.com/WCaoTVsQzz5CZQh5jFBUhL https://cassyni.com/slides/outline/LppycbPUgNAqFnWw21PGh3 https://cassyni.com/events/LppycbPUgNAqFnWw21PGh3/abstract https://cassyni-user-files-prod.s3.amazonaws.com/CLnywZSZhPuaD5YEaFiYRk https://cassyni.com/events/LppycbPUgNAqFnWw21PGh3?videoPreview=1 The CARE-AI Study: Creating Accountable and Responsible Ethics for Artificial Intelligence for Healthcarenohttps://cassyni.com/events/LppycbPUgNAqFnWw21PGh3?videoPreview=12025-04-16T08:00:00+00:003503.76AAMCAs AI becomes more integrated into healthcare, it brings both transformative potential and complex ethical challenges. This session introduces a professionalism framework for ethical AI use, developed through international collaboration. Participants explored real-world cases, research insights, and actionable guidance for responsible AI adoption. This webinar is part of the Artificial Intelligence in Academic Medicine Webinar Series, hosted by the AAMC. It explores critical concepts, the current landscape, and practical strategies drawn from various perspectives and institutions to support you in navigating the evolving world of AI in academic medicine. For more information, see [the complete series webpage](https://www.aamc.org/about-us/mission-areas/medical-education/artificial-intelligence-ai-academic-medicine-webinar-series). https://cassyni-user-files-prod.s3.amazonaws.com/CLnywZSZhPuaD5YEaFiYRk https://cassyni.com/slides/outline/PJ4zr1d6sewKcizVZhHuQy https://cassyni.com/events/PJ4zr1d6sewKcizVZhHuQy/abstract https://cassyni-user-files-prod.s3.amazonaws.com/WfycE9ZCvoJ39qj9beQrjG https://cassyni.com/events/PJ4zr1d6sewKcizVZhHuQy?videoPreview=1 Cybersecurity and Internet Governancenohttps://cassyni.com/events/PJ4zr1d6sewKcizVZhHuQy?videoPreview=12018-03-08T09:00:00+00:003304.12 School of Public PolicyThis seminar examines the evolving relationship between cybersecurity and internet governance within a geopolitical context, emphasizing the increasing prominence of cybersecurity concerns over traditional internet governance discourse. The analysis distinguishes between societal cybersecurity—characterized by a global, multi-stakeholder approach focusing on individual and organizational security as a positive-sum game—and national cybersecurity, which frames cyberspace as segmented by territorial sovereignty and prioritizes state-centric, zero-sum security dynamics. The discussion highlights how cybersecurity drives the nationalization or “alignment” of the internet, manifesting in centralized threat intelligence, national technical standards, and restrictions on foreign technology ownership, exemplified by cases such as the U.S. government’s scrutiny of companies like Qualcomm and Kaspersky. The seminar further explores the conceptual framework of information security through confidentiality, integrity, and availability, advocating an adversarial mindset to anticipate and mitigate threats ranging from insider attacks and organized cybercrime to state-sponsored espionage and sabotage. Notable cyber incidents, including ransomware attributed to North Korea, the Flame virus, and the Stuxnet worm, illustrate the complexity and scale of cyber threats. The seminar also addresses the contentious debate over whether information content—such as misinformation campaigns—constitutes an information security issue, noting a shift toward recognizing its geopolitical implications. Overall, the analysis underscores the tension between the internet’s inherently global, interconnected nature and the increasing efforts by nation-states to impose territorial control, with significant implications for future governance, security policy, and international cooperation.https://cassyni-user-files-prod.s3.amazonaws.com/WfycE9ZCvoJ39qj9beQrjG https://cassyni.com/slides/outline/KqXmXE6RoT4gb2gvv2uwt9 https://cassyni.com/events/KqXmXE6RoT4gb2gvv2uwt9/abstract https://cassyni-user-files-prod.s3.amazonaws.com/TxQnUPVpWnFYddNFiHoh1p https://cassyni.com/events/KqXmXE6RoT4gb2gvv2uwt9?videoPreview=1 Diversity and Inclusion Council Panel Discussionnohttps://cassyni.com/events/KqXmXE6RoT4gb2gvv2uwt9?videoPreview=12018-09-26T08:00:00+00:003681.92 School of Public PolicyThis panel discussion addresses the ongoing challenges and complexities of diversity, equity, and inclusion (DEI) within academic and institutional contexts, emphasizing both personal experiences and systemic analysis. The discourse foregrounds the distinction between diversity as mere presence (“being invited to the party”) and inclusion as active participation (“being asked to dance”), highlighting persistent underrepresentation of women and minorities in STEM and academia despite decades of policy interventions. Representation ratios and longitudinal data illustrate incremental but insufficient progress, underscoring the need for nuanced, population-specific strategies rather than one-size-fits-all solutions. Philosophical reflections emphasize intellectual modesty, moral imagination, and the discomfort inherent in confronting partial perspectives and systemic inequities, advocating for openness to learning and dialogue across differences. The discussion also interrogates the tension between individual intentions and structural forces, cautioning against scapegoating while recognizing the persistence of bad faith actors and systemic barriers. Pedagogical approaches such as serial testimony and curricular inclusivity are proposed to foster systemic understanding and empathy. The panel critiques shifts in rhetoric from civil rights and justice toward diversity and inclusion, questioning potential dilution of structural justice aims. Practical guidance for students includes engagement with courses on race, class, and gender, and recommended readings on systems thinking to comprehend and challenge entrenched inequities. The conversation concludes with affirmations of belonging and the imperative to expand institutional spaces to be genuinely inclusive, fostering collective responsibility for transformative change.https://cassyni-user-files-prod.s3.amazonaws.com/TxQnUPVpWnFYddNFiHoh1p https://cassyni.com/slides/outline/WD9TVagT24h77Xz4w8rqZf https://cassyni.com/events/WD9TVagT24h77Xz4w8rqZf/abstract https://cassyni-user-files-prod.s3.amazonaws.com/3Mfxzh2ggf7zjLXghDVzHU https://cassyni.com/events/WD9TVagT24h77Xz4w8rqZf?videoPreview=1 Community consequences of the opioid epidemicnohttps://cassyni.com/events/WD9TVagT24h77Xz4w8rqZf?videoPreview=12023-03-23T09:00:00+00:003493.6 School of Public PolicyThe opioid epidemic in the United States constitutes a profound public health emergency with extensive community-level consequences beyond individual addiction. This body of research synthesizes findings from diverse disciplinary perspectives to elucidate the epidemic’s broader societal impacts, including effects on child welfare, education, food insecurity, housing stability, and public budgets. Analyses reveal that opioid use disorder intersects with critical social determinants such as food and housing insecurity, complicating treatment success and necessitating holistic policy approaches. Demographically, overdose mortality exhibits significant variation by age, race, and geography, with American Indian and Black populations experiencing disproportionately high rates, and shifting patterns linked to economic decline and social despair. Prenatal opioid exposure adversely affects infant health outcomes, though controlling for confounding factors reduces estimated effects, underscoring the importance of early treatment access and addressing barriers such as criminalization of substance use during pregnancy. Children bear substantial indirect burdens, evidenced by rising foster care placements associated with parental opioid use; expanded access to medication-assisted treatment programs correlates with a 22% reduction in foster care entries, suggesting benefits for family stability. Educational outcomes also suffer, as communities heavily impacted by opioids show modest but consistent declines in student learning rates, likely mediated by strained school resources and increased special education needs. Housing instability is both a cause and consequence of opioid addiction, though treatment programs alone do not suffice to address homelessness. These findings highlight the necessity for comprehensive, multi-sectoral interventions that address the complex social and structural dimensions of the opioid crisis to mitigate its enduring community harms.https://cassyni-user-files-prod.s3.amazonaws.com/3Mfxzh2ggf7zjLXghDVzHU https://cassyni.com/slides/outline/Who4YGKyTXFA7JWxXa9dpy https://cassyni.com/events/Who4YGKyTXFA7JWxXa9dpy/abstract https://cassyni-user-files-prod.s3.amazonaws.com/XnSDagm8v5YJbHQNfCxmjc https://cassyni.com/events/Who4YGKyTXFA7JWxXa9dpy?videoPreview=1 The Domestic Benefits of Subversive Foreign Propaganda: The RT (Russia Today) News Network and Geopolitical Muckrakingnohttps://cassyni.com/events/Who4YGKyTXFA7JWxXa9dpy?videoPreview=12017-10-20T08:00:00+00:003386.28 School of Public PolicyThis analysis examines the role of RT (Russia Today) within the context of U.S. alternative media and its implications for domestic information environments. RT, a Russian government-funded 24-hour news network with extensive international reach, is often labeled as foreign propaganda aimed at subverting U.S. political stability. However, this study situates RT within the longstanding American tradition of alternative media, which seeks to provide critical perspectives overlooked by mainstream outlets. Employing content analysis focused on program hosts and guests’ institutional affiliations rather than speech content, the research evaluates RT’s flagship show Crosstalk and other programs. Findings reveal that RT aggregates a range of institutionally credible American voices from diverse political backgrounds, including established journalists, academics, and activists, many of whom also appear in recognized U.S. alternative media. The content predominantly critiques power structures, corporate influence, and government legitimacy, aligning with domestic critical discourses rather than overt foreign propaganda narratives. Post-2014 geopolitical tensions correspond with a decline in participation by some American figures, suggesting reputational risks. The study highlights RT’s function as a large-scale platform addressing historical challenges faced by U.S. alternative media—namely distribution and content legitimacy—by providing a national outlet for marginalized voices. These findings complicate simplistic characterizations of RT as purely subversive, suggesting it also serves domestic interests in expanding media pluralism and free speech, albeit with an overlay of foreign state interests. The analysis underscores the need for nuanced policy approaches balancing media independence, national security, and democratic discourse.https://cassyni-user-files-prod.s3.amazonaws.com/XnSDagm8v5YJbHQNfCxmjc https://cassyni.com/slides/outline/RGfR2kDCdVA5iSGivf9qqX https://cassyni.com/events/RGfR2kDCdVA5iSGivf9qqX/abstract https://cassyni-user-files-prod.s3.amazonaws.com/XfGpKWrFoiQHB35bXpfe6i https://cassyni.com/events/RGfR2kDCdVA5iSGivf9qqX?videoPreview=1 Internet Routing Registries, Data Governance and Securitynohttps://cassyni.com/events/RGfR2kDCdVA5iSGivf9qqX?videoPreview=12016-05-24T08:00:00+00:001385.08 School of Public PolicyThis study examines Internet routing security through the lens of data governance, emphasizing the organizational practices, policies, and incentives that shape the exchange of routing information among Internet Service Providers (ISPs). The decentralized and distributed nature of Internet Routing Registries (IRRs) offers flexibility but also introduces challenges such as inaccurate or outdated routing data, misaligned incentives, high transaction costs, and unmanageable interdependencies. Empirical insights from interviews with network operators reveal that participation in IRRs suffers from collective action problems, leading to underproduction and limited data accuracy. Alternative security mechanisms, including Resource Public Key Infrastructure (RPKI), BGPSEC, and commercial route monitoring services, address some vulnerabilities but face limitations related to cost, complexity, and the need for contextual policy data. The analysis further explores initiatives like MANRS, which promote bilateral policy validation and filtering but do not fully resolve systemic governance issues. The potential application of blockchain technology to IRRs is considered promising due to its distributed consensus, immutable ledger, and provable timeline features, which could enhance data authenticity, consistency, and collective action among operators. However, challenges remain regarding integration with existing standards such as RPSL and scalability for large ISPs. The findings highlight the critical role of governance structures alongside technical solutions in improving routing security, suggesting that future work should explore hybrid approaches combining blockchain, software-defined networking, and community norms to address persistent economic and operational barriers.https://cassyni-user-files-prod.s3.amazonaws.com/XfGpKWrFoiQHB35bXpfe6i https://cassyni.com/slides/outline/61NrE5yjWdZCwrEE1MZY9K https://cassyni.com/events/61NrE5yjWdZCwrEE1MZY9K/abstract https://cassyni-user-files-prod.s3.amazonaws.com/4cmz36BGmu6ZDC5RKpqyYA https://cassyni.com/events/61NrE5yjWdZCwrEE1MZY9K?videoPreview=1 From HHI to HRI: Which Facets of Ethical Decision-Making Should Inform a Robot?nohttps://cassyni.com/events/61NrE5yjWdZCwrEE1MZY9K?videoPreview=12023-05-24T08:00:00+00:002044.6 School of Public PolicyThis study investigates ethical decision-making norms relevant to human-robot interaction (HRI) by examining how humans assess appropriate robot behavior in socially situated contexts. Motivated by the broader goal of programming robots to make ethical decisions akin to humans, the research focuses on physically embodied social robots engaging in constrained interactions such as playing board games or teaching tasks. Surveys were conducted with two main participant groups: average American adults and ethics experts. Scenarios included an adult playing Connect Four with a child or older adult, teaching an older adult to sort pills, and teaching a child to swim, with particular attention to whether deception (e.g., deliberately losing a game) is ethically permissible to promote learning or perseverance. Variations in the surveys explored human-human versus human-robot interactions, the presence of video stimuli, and contextual factors such as the age and emotional state of the human interactant and the level of risk involved. Preliminary findings indicate nuanced differences in ethical judgments depending on these factors; for example, video presentation of robot interactions influenced participants’ acceptance of deceptive behavior. Ethics experts were asked to apply formal ethical frameworks, while lay participants provided folk morality perspectives. The analysis aims to identify generalizable ethical norms within restricted social contexts that could inform robot behavior design. The study highlights the complexity and variability of ethical assessments even among humans, underscoring challenges in formalizing such norms for robots and suggesting directions for future research on contextual and normative factors in ethical HRI.https://cassyni-user-files-prod.s3.amazonaws.com/4cmz36BGmu6ZDC5RKpqyYA https://cassyni.com/slides/outline/FtLw9kvEHndXoNEFWvKuHF https://cassyni.com/events/FtLw9kvEHndXoNEFWvKuHF/abstract https://cassyni-user-files-prod.s3.amazonaws.com/GPmro6aX67ywD7c7Q2TsAE https://cassyni.com/events/FtLw9kvEHndXoNEFWvKuHF?videoPreview=1 Physics-preserving AI-Accelerated simulations of plasma turbulencenohttps://cassyni.com/events/FtLw9kvEHndXoNEFWvKuHF?videoPreview=12024-01-25T06:00:00+00:002157.36Journal of Plasma PhysicsTurbulence in fluids, gases, and plasmas remains an open problem of both practical and fundamental importance. Its irreducible complexity usually cannot be tackled computationally in a brute-force style. Combining Large Eddy Simulation (LES) techniques with Machine Learning (ML) allows us to only retain the largest dynamics explicitly, while small-scale dynamics are described by an ML-based sub-grid-scale model. Applying this novel approach to self-driven plasma turbulence allows us to remove large parts of the inertial range, reducing the computational effort by about three orders of magnitude, all while retaining the full statistical description of the turbulent systems' physical properties.https://cassyni-user-files-prod.s3.amazonaws.com/GPmro6aX67ywD7c7Q2TsAE https://cassyni.com/events/AwrtgvSyuD6WQGWuWScuZ7/abstract https://cassyni-user-files-prod.s3.amazonaws.com/2HviXHUttXkmUbQfgVaB9Y https://cassyni.com/slides/outline/MKWCmuYtXBef5Z6Hmx7a6R https://cassyni.com/events/MKWCmuYtXBef5Z6Hmx7a6R/abstract https://cassyni-user-files-prod.s3.amazonaws.com/BTCpGbRivWFqesfE6Cm2ei https://cassyni.com/events/MKWCmuYtXBef5Z6Hmx7a6R?videoPreview=1 The Earth BioGenome Project Phase II: illuminating the eukaryotic treenohttps://cassyni.com/events/MKWCmuYtXBef5Z6Hmx7a6R?videoPreview=12025-09-18T14:00:00+00:005474.72Frontiers in Science#### Sequencing the genomes of eukaryotic species through inclusive, global collaboration Discover the next phase of the [Earth BioGenome Project (EBP)](https://www.earthbiogenome.org/), which aims to sequence the DNA of all known eukaryotic species to protect biodiversity, improve global health, and drive scientific innovation. In their [Frontiers in Science lead article](https://www.frontiersin.org/journals/science/articles/10.3389/fsci.2025.1514835/full), the EBP leaders reveal a refined strategy to scale up the sequencing of 150,000 species. Thanks to major technical advances, high-quality genomes can now be produced 10 times faster and at significantly lower cost. Hear the authors discuss how EBP’s next phase will accelerate biodiversity research, support global conservation, and extend genomic benefits to underserved regions using mobile sequencing labs. Alongside a panel of fellow experts, they will explore the importance of open data sharing, training local scientists, and sequencing at the source—ensuring inclusivity, capacity-building, and benefit-sharing, especially in the Global South. If you would like to join, [register here](events.frontiersin.org/earth-biogenome-project/cassyni). https://cassyni-user-files-prod.s3.amazonaws.com/BTCpGbRivWFqesfE6Cm2ei https://cassyni.com/events/Ft35tqFUrpSYC7ZqNg13LR/seminar/qa https://cassyni.com/slides/outline/Ft35tqFUrpSYC7ZqNg13LR https://cassyni.com/events/Ft35tqFUrpSYC7ZqNg13LR/abstract https://cassyni-user-files-prod.s3.amazonaws.com/JmLFxQz5uaM4Knq62E8AGn https://cassyni.com/events/Ft35tqFUrpSYC7ZqNg13LR?videoPreview=1 Thieme Cheminar: Hypervalent Halogens in Organic Synthesisnohttps://cassyni.com/events/Ft35tqFUrpSYC7ZqNg13LR?videoPreview=12026-06-02T12:00:00+00:007430.36Thieme GroupHypervalent halogen chemistry has evolved from an academic curiosity into a cornerstone of modern synthetic methodology. Once valued primarily as environmentally friendlier alternatives to metal-based oxidants, hypervalent halogen reagents are now central to a wide range of sophisticated functional group transfer reactions. Their unique reactivity profiles continue to fuel innovation in sustainable synthesis, complex molecule construction, and reaction design. This Thieme Cheminar brings together four leading contributors to the *Science of Synthesis* reference work *Hypervalent Halogens in Organic Synthesis*: **Naohiko Yoshikai**, **Yiyun Chen**, **Maria Manuel B. Marques**, and **Tanja Gulder**. Each speaker will discuss current advances within their respective areas of expertise, offering diverse perspectives on the synthesis, mechanistic understanding, and synthetic application of hypervalent halogen compounds. The session will collectively highlight conceptual breakthroughs, new reagent classes, and emerging practical methodologies that are shaping this rapidly expanding field. Designed for chemists interested in oxidative chemistry, reagent design, and modern synthetic strategies, this event provides a concise yet insightful orientation to the state of the art and future directions of hypervalent halogen research. https://cassyni-user-files-prod.s3.amazonaws.com/JmLFxQz5uaM4Knq62E8AGn https://cassyni.com/events/UjEGUAFm73xVa8ckjpyJWR/seminar/qa https://cassyni.com/slides/outline/UjEGUAFm73xVa8ckjpyJWR https://cassyni.com/events/UjEGUAFm73xVa8ckjpyJWR/abstract https://cassyni-user-files-prod.s3.amazonaws.com/roSA9d9daWHpvAbNZP7dG https://cassyni.com/events/UjEGUAFm73xVa8ckjpyJWR?videoPreview=1 Uterine Rhythms: navigating the changes during the estrus cyclenohttps://cassyni.com/events/UjEGUAFm73xVa8ckjpyJWR?videoPreview=12025-09-30T03:00:00+00:003181.32The Auckland Bioengineering InstituteThe uterus remains understudied in its normal function. Hormonal fluctuations, driven by the menstrual cycle (humans) or estrus cycle (non-menstruating mammals), significantly influence uterine activity. My thesis combined experimental data and mathematical modelling to describe changes in uterine anatomy and electrophysiology throughout the estrus cycle in rats. This presentation will cover the anatomical and electrical variations in the rat uterus during the estrus cycle, and present mathematical models of rat uterine electrophysiology. High-resolution micro-computed tomography (𝜇CT) was used to capture rat uterine muscle anatomy at different cycle stages. From these scans, anatomical variations were quantified and muscle fibre orientations extracted using structure tensors. Electrical activity was recorded in vivo using high-resolution electrode arrays. The electrical signals were processed to characterise the frequency and duration of events, and the propagation patterns and velocities across the estrus cycle. A mathematical model of the non-pregnant rat uterine smooth muscle cell was developed from an existing pregnant model, including new progesterone and estrogen components which was then embedded in a continuum model of whole organ function. This work provides novel methods for anatomical assessment of the uterus, high-resolution mapping of uterine electrical activity, and mathematical modelling of the electrophysiology of the non-pregnant rat uterus. https://cassyni-user-files-prod.s3.amazonaws.com/roSA9d9daWHpvAbNZP7dG https://cassyni.com/slides/outline/6W45PQ99MT32mcoamJHqYh https://cassyni.com/events/6W45PQ99MT32mcoamJHqYh/abstract https://cassyni-user-files-prod.s3.amazonaws.com/7kgLwYMBWYA3wzko6Z83zv https://cassyni.com/events/6W45PQ99MT32mcoamJHqYh?videoPreview=1 Viral variants: From Covid to the flunohttps://cassyni.com/events/6W45PQ99MT32mcoamJHqYh?videoPreview=12021-11-18T06:00:00+00:003674.48Part of the nonprofit Annual Reviews organizationNew variants of the coronavirus behind the Covid-19 pandemic arise constantly, with some, such as Delta, driving new waves of infections and subsequent deaths. What kinds of genetic changes make some variants of SARS-CoV-2 more dangerous and why have virologists long been concerned about coronaviruses in particular? And what do studies of old foes such as influenza, HIV and SARS tell us about the course that SARS-CoV-2 may take and how we might prepare for the changes ahead? https://cassyni-user-files-prod.s3.amazonaws.com/7kgLwYMBWYA3wzko6Z83zv https://cassyni.com/events/6zhgS5nfnub5mPLUMjadp1/abstract https://cassyni-user-files-prod.s3.amazonaws.com/BLf8dF1kcVz59sKVtnEzDk https://cassyni.com/slides/outline/Za2vZftxsW1NX6EkpaqpZ https://cassyni.com/events/Za2vZftxsW1NX6EkpaqpZ/abstract https://cassyni-user-files-prod.s3.amazonaws.com/TQuVUT7NuFL6QwoddWCoYS https://cassyni.com/events/Za2vZftxsW1NX6EkpaqpZ?videoPreview=1 Generalised Lagrangian mean: formulation and computationnohttps://cassyni.com/events/Za2vZftxsW1NX6EkpaqpZ?videoPreview=12024-11-01T06:00:00+00:003129.92Leeds Institute for Fluid DynamicsMany fluid dynamical phenomena are the result of interactions between small-scale or high-frequency fluctuations – associated with waves or turbulence – and mean flows. Modelling these requires some form of averaging to obtain coarse-grained models in which the effect of fluctuations is parameterised. In this context, Lagrangian averaging, whereby averages are computed along fluid trajectories, has advantages over the more straightforward Eulerian averaging, mainly because it preserves the advective structure of the equations of motion. The theory of generalised Lagrangian mean (GLM) formulated by Andrews & McIntyre provides the basis for the derivation of convenient Lagrangian-averaged models. In this talk, I will introduce this theory and show how a geometric perspective helps its interpretation and generalisation. I will then discuss recently introduced numerical methods for the computation of (temporal) Lagrangian averages from numerical simulation data. These methods avoid the explicit tracking of particles, replacing it by the solution of partial different equations that can be carried out on-the-fly, in tandem with the simulation.https://cassyni-user-files-prod.s3.amazonaws.com/TQuVUT7NuFL6QwoddWCoYS https://cassyni.com/slides/outline/GP2AK55e8c7Md8ocGs4Cgd https://cassyni.com/events/GP2AK55e8c7Md8ocGs4Cgd/abstract https://cassyni-user-files-prod.s3.amazonaws.com/ocNMBWfKHTcZ9rCczbtLe https://cassyni.com/events/GP2AK55e8c7Md8ocGs4Cgd?videoPreview=1 Generative AI in Organizationsnohttps://cassyni.com/events/GP2AK55e8c7Md8ocGs4Cgd?videoPreview=12025-09-26T01:00:00+00:001785.04Risk Sciences[***Risk Sciences***](https://www.keaipublishing.com/en/journals/risk-sciences/) aims to foster diverse, multidisciplinary insights in risk sciences, bridging theory and practice through a series of academic activities. Professor Li's research interests primarily lie in steam collaboration, organizational network analysis, individual and team innovation mechanism, leadership, big data in organizational research, and Chinese management concepts. This speech record is an excerpt from Professor Li's keynote speech for the [Risk Sciences Colloquium – Artificial Intelligence and Risk Management](https://www.keaipublishing.com/en/journals/risk-sciences/event/risk-sciences-colloquium-artificial-intelligence-and-risk-management/) , which was held on September, 26, 2025, in Beijing, China.https://cassyni-user-files-prod.s3.amazonaws.com/ocNMBWfKHTcZ9rCczbtLe https://cassyni.com/slides/outline/8yJ6cpNmYjoqs6chihSaEZ https://cassyni.com/events/8yJ6cpNmYjoqs6chihSaEZ/abstract https://cassyni-user-files-prod.s3.amazonaws.com/PA8HkWFv7yYvonaw969sEN https://cassyni.com/events/8yJ6cpNmYjoqs6chihSaEZ?videoPreview=1 Advancing SHM: Leveraging AI-Driven Algorithms to Integrate Multimodal Sensor Data, Models, and Structures at a Territorial Scalenohttps://cassyni.com/events/8yJ6cpNmYjoqs6chihSaEZ?videoPreview=12025-09-17T07:00:00+00:002623.52ArtIStE - Artificial Intelligence in Structural EngineeringAdvancements in AI and sensing technologies are transforming structural health monitoring (SHM), a crucial tool for maintaining aging infrastructure and cultural heritage structures. Despite progress in AI-driven analysis and selfsensing materials, effective prognosis in civil engineering remains challenging due to the gap between data-driven insights and physics-based models. To enable risk-informed decision-making on a larger scale, SHM must evolve into a multi-scale framework that integrates diverse sensor data with computational modeling, shifting from individual structures to interconnected networks. This talk explores cutting-edge SHM research, focusing on the integration of advanced sensing, AI analytics, and computational models. Key topics include self-sensing materials for smart masonry, deep learning and statistical pattern recognition for damage classification, and metamodeling with Bayesian inference for improved structural assessment. These innovations pave the way for smarter, data-driven infrastructure and built heritage management.https://cassyni-user-files-prod.s3.amazonaws.com/PA8HkWFv7yYvonaw969sEN https://cassyni.com/slides/outline/RmNGJgtVsfZgMuJhtGiK9o https://cassyni.com/events/RmNGJgtVsfZgMuJhtGiK9o/abstract https://cassyni-user-files-prod.s3.amazonaws.com/FDsCYZNsPrc3jwx5PxYPm8 https://cassyni.com/events/RmNGJgtVsfZgMuJhtGiK9o?videoPreview=1 Shaping the Future of Science: A Multi-Stakeholder Dialoguenohttps://cassyni.com/events/RmNGJgtVsfZgMuJhtGiK9o?videoPreview=12026-01-13T10:00:00+00:003951.04Academic Publishing in EuropeScience today operates in a rapidly changing environment, where more traditional notions of academic excellence are being challenged by new expectations for openness, impact, and accountability. This panel will explore several dimensions of this shift shaping the future of research and scholarly communication. First, we ask what “excellence” should mean in the 21st century and how that concept is evolving across disciplines and contexts. Second, we examine research culture and the design of reward systems: how incentives can foster integrity, collaboration, and societal relevance, and what accountability looks like for stakeholders in the system. Finally, we turn to the dissemination of research, considering what role peer review and a consideration of audiences can and should play in the evolution of academic publishing.https://cassyni-user-files-prod.s3.amazonaws.com/FDsCYZNsPrc3jwx5PxYPm8 https://cassyni.com/slides/outline/Eu6yHeexDbNk5RrT7iZLQD https://cassyni.com/events/Eu6yHeexDbNk5RrT7iZLQD/abstract https://cassyni-user-files-prod.s3.amazonaws.com/LFagkSvekNrLwtrvmqcgQv https://cassyni.com/events/Eu6yHeexDbNk5RrT7iZLQD?videoPreview=1 Reporting your research: How to use APA Style Journal Article Reporting Standards (JARS)nohttps://cassyni.com/events/Eu6yHeexDbNk5RrT7iZLQD?videoPreview=12025-11-03T09:00:00+00:003657.68NoneLearn about the process and unique benefits of reporting your research using the [APA Style Journal Article Reporting Standards (JARS)](https://apastyle.apa.org/jars?utm_source=apa.org&utm_medium=referral&utm_content=/education-career/training/reporting-research-jars&utm_term=body). Hear from experts Heidi Levitt, PhD, and Arthur Nezu, PhD, as they discuss their experience with APA Style JARS as authors, editors, instructors, and psychological scientists.https://cassyni-user-files-prod.s3.amazonaws.com/LFagkSvekNrLwtrvmqcgQv https://cassyni.com/events/ASuSPK8i2nMToFKbmm1FLy/seminar/qa https://cassyni.com/slides/outline/ASuSPK8i2nMToFKbmm1FLy https://cassyni.com/events/ASuSPK8i2nMToFKbmm1FLy/abstract https://cassyni-user-files-prod.s3.amazonaws.com/8ov7v4MEvG2WWfRqKd21E6 https://cassyni.com/events/ASuSPK8i2nMToFKbmm1FLy?videoPreview=1 A journey through Deep Neural Network Debiasingnohttps://cassyni.com/events/ASuSPK8i2nMToFKbmm1FLy?videoPreview=12026-02-03T13:00:00+00:003495.44Journal on Image and Video ProcessingDeep neural networks frequently encode and propagate biases arising from data, model design, and deployment contexts, posing significant challenges for reliable and lawful AI systems. This presentation surveys debiasing techniques for deep neural networks, situating them within the regulatory constraints introduced by the AI Act. We compare supervised and unsupervised debiasing methods, emphasizing their underlying assumptions, optimization objectives, and practical trade-offs. The talk then addresses bias discovery and bias naming as foundational problems for systematic bias mitigation. Finally, we discuss emerging research directions, including privacy-aware debiasing, fairness certification, and machine unlearning, highlighting open technical challenges and unresolved tensions between fairness, robustness, and compliance.https://cassyni-user-files-prod.s3.amazonaws.com/8ov7v4MEvG2WWfRqKd21E6 https://cassyni.com/events/QHT5HGToxepk5f1zKQyLuT/abstract https://cassyni-user-files-prod.s3.amazonaws.com/V7XbdKRNw8TojSSMB9yVCr https://cassyni.com/slides/outline/XhB8yXAgYX8aaEYTHHq5KT https://cassyni.com/events/XhB8yXAgYX8aaEYTHHq5KT/abstract https://cassyni-user-files-prod.s3.amazonaws.com/3myUsRDeu3ybeuckK4Sn46 https://cassyni.com/events/XhB8yXAgYX8aaEYTHHq5KT?videoPreview=1 MEMS Gravimeters – Developing Practical Sensors for Gravity Applicationsnohttps://cassyni.com/events/XhB8yXAgYX8aaEYTHHq5KT?videoPreview=12026-05-06T14:00:00+00:003501.2UK Microsystems NetworkMEMS gravimeters first demonstrated an ability to measure Earth tides inside a laboratory in Glasgow in 2015 and since then the systems have been developed and used for a range of applications. The talk will first provide a historical look at the design and demonstration of that first MEMS gravimeters at Glasgow before describing the work to develop sensors for field trials across multiple applications. Initial field trials compared the wee-g MEMS gravimeter to commercial gravimeters through measuring gravity in a lift and also across a bridge in Kelvingrove Park in Glasgow. This allowed calibrated gravity maps to be created enabling all future gravimeters to be tested on these two calibrated tests areas before taking them further afield for trials. Further tests at the National Infrastructure Facility in Birmingham beside a commercial Scintrex CG5 have demonstrated comparable signal to noise with commercial systems through the detection of buried pipes when used in real world applications. Results will be shown from four wee-g gravimeters that spent multiple years on Mount Etna in Italy as part of an EC project for vulcanology applications and more recent work on Poas volcano in Costa Rica where unique signals have been observed before the volcano erupted. Further work on measuring the water table height has demonstrated use cases for finding water in desert regions whilst also enabling predictions for farming and flooding on flood planes without requiring wells or bore holes to be drilled. Finally examples of detecting buried tunnels will be described through field trials in Glasgow Botanical Gardens where measurements of disused Victorian railway tunnels provide demonstrations of finding buried assets with many applications in civil engineering.https://cassyni-user-files-prod.s3.amazonaws.com/3myUsRDeu3ybeuckK4Sn46 https://cassyni.com/events/MKCMWyt96DTfTzr2fsBNvR/seminar/qa https://cassyni.com/slides/outline/MKCMWyt96DTfTzr2fsBNvR https://cassyni.com/events/MKCMWyt96DTfTzr2fsBNvR/abstract https://cassyni-user-files-prod.s3.amazonaws.com/BTCURAWJ2uUyXcQPRyGHRQ https://cassyni.com/events/MKCMWyt96DTfTzr2fsBNvR?videoPreview=1 Time Machines: Business Aviation's Dynamic Journeynohttps://cassyni.com/events/MKCMWyt96DTfTzr2fsBNvR?videoPreview=12026-05-04T15:00:00+00:003388.64AIAATime Machines: Business Aviation's Dynamic Journey is the definitive story of how business aviation transformed the way the world works, connects, and competes. From its humble beginnings in the 1920s to the game-changing arrival of business jets in the 1960s—and its evolution into today's global industry—this book takes readers on an unforgettable journey through innovation and ambition. Time Machines goes beyond history. It reveals how business aviation has shaped--and been shaped by—the global economy, geopolitics, technology, and even popular culture. Looking forward, the book explores the challenges and opportunities that will define business aviation in the late 2020s and beyond.https://cassyni-user-files-prod.s3.amazonaws.com/BTCURAWJ2uUyXcQPRyGHRQ https://cassyni.com/events/DuUHpjBGWM9see5nd6DNnh/seminar/qa https://cassyni.com/slides/outline/DuUHpjBGWM9see5nd6DNnh https://cassyni.com/events/DuUHpjBGWM9see5nd6DNnh/abstract https://cassyni-user-files-prod.s3.amazonaws.com/BYjmR9FaRpPcNJegMbeVgr https://cassyni.com/events/DuUHpjBGWM9see5nd6DNnh?videoPreview=1 Engineering the Lightweight Vehicle: A Journey with Automotive Compositesnohttps://cassyni.com/events/DuUHpjBGWM9see5nd6DNnh?videoPreview=12026-03-17T13:00:00+00:003532.24Department of AeronauticsAutomotive lightweighting demands integrated control of material architecture, processing physics, and structural performance under production constraints. This talk presents two composite-intensive demonstrations enabled through a process–structure–property–performance framework. The first details the development of the world’s first production-ready thermoplastic carbon fiber composite door, achieving 45% structural mass reduction and 52% parts consolidation while satisfying FMVSS 214 and IIHS side-impact requirements. A manufacturing-to-response pathway was established, coupling thermoforming simulations, fiber reorientation and thickness evolution, residual stress prediction, and progressive failure modeling to validated static and dynamic crash performance. The second case study illustrates how subsystem-level innovations can extend to a composite-intensive glider architecture, integrating multi-material joining strategies and subsystem-level load path optimization to enable scalable lightweight body structures. Central to both efforts is a manufacturing-to-response framework that captures process-induced effects, fiber architecture evolution, and structural behavior within predictive simulation tools. The presentation concludes with insights into the AIM EFRC vision—leveraging accelerated materials discovery, multiscale modeling, and AI-driven design to transform how advanced composites are conceived, optimized, and deployed for next-generation lightweight vehicles.https://cassyni-user-files-prod.s3.amazonaws.com/BYjmR9FaRpPcNJegMbeVgr https://cassyni.com/events/GNiK49QthdvN1aZMAn81Wd/seminar/qa https://cassyni.com/slides/outline/GNiK49QthdvN1aZMAn81Wd https://cassyni.com/events/GNiK49QthdvN1aZMAn81Wd/abstract https://cassyni-user-files-prod.s3.amazonaws.com/RQ8BzUHwRa5BncJNxk51Ae https://cassyni.com/events/GNiK49QthdvN1aZMAn81Wd?videoPreview=1 An introduction to Space medicine and near term human rated space ambitionsnohttps://cassyni.com/events/GNiK49QthdvN1aZMAn81Wd?videoPreview=12026-03-17T03:00:00+00:004138.76The Auckland Bioengineering InstituteHuman Factors and the necessary counter-measures and technologies in support of human space exploration, focusing on mitigating the highest risks to crew health and performance. There is a Risk of Adverse Mission Outcomes Due to Earth Independent Human-Systems Operations. What enables improvement of human spaceflight medical, environmental and human factors standards. What is the future of Space travel. The New Zealand Space Health Research Network brings researchers together who are reducing medical and environmental risks, to reduce human systems resource requirements (mass, volume, power, data, etc.), and to ensure effective human-system integration across exploration mission systems. There is a need to identify the Human Systems Integration (HSI) – relevant crew health and performance outcomes, measures, and metrics, needed to characterize and mitigate risk, for future exploration missions. Can your human health research contribute to a space future.https://cassyni-user-files-prod.s3.amazonaws.com/RQ8BzUHwRa5BncJNxk51Ae https://cassyni.com/events/8xzFMti27mcrFYNSccWP4Z/seminar/qa https://cassyni.com/slides/outline/8xzFMti27mcrFYNSccWP4Z https://cassyni.com/events/8xzFMti27mcrFYNSccWP4Z/abstract https://cassyni-user-files-prod.s3.amazonaws.com/NZHQqo45q1DpwHMDYaiviA https://cassyni.com/events/8xzFMti27mcrFYNSccWP4Z?videoPreview=1 (In)Fertility in South Asianohttps://cassyni.com/events/8xzFMti27mcrFYNSccWP4Z?videoPreview=12026-04-01T13:30:00+00:002517.44Women's Health"The absence of conversations regarding the lived experiences of childlessness and infertility in policy discourse points towards the continued importance of treating women as population targets. Engaging with (in)fertility through narratives and qualitative data privileges and highlights the need for inclusive discussions on technology and the socio-medical management of fertility life spans." - Dr Anindita Majumdar, Guest Editor of the Special Collection “Women’s health cannot be reduced solely to maternal health. Mothers are just one group within a diverse population of women. Non-mother women should be recognised as subjects of analysis and have equitable access to healthcare services, particularly in the Global South.” - Prof Papreen Nahar, Guest Editor of the Special Collectionhttps://cassyni-user-files-prod.s3.amazonaws.com/NZHQqo45q1DpwHMDYaiviA https://cassyni.com/events/JqyxQCAQJHcuFY4sQkDBq7/seminar/qa https://cassyni.com/events/JqyxQCAQJHcuFY4sQkDBq7/abstract https://cassyni-user-files-prod.s3.amazonaws.com/QHn9seX1StyPU2WX8VMP2E https://cassyni.com/events/JqyxQCAQJHcuFY4sQkDBq7?videoPreview=1 Towards a global plastics treaty: Navigating policy preferences and economic interestsnohttps://cassyni.com/events/JqyxQCAQJHcuFY4sQkDBq7?videoPreview=12026-09-15T14:00:00+00:002024.08Cambridge PrismsAt the fifth session of the United Nations (UN) Environment Assembly in March 2022, UN member states were mandated to negotiate an international, legally binding instrument on plastic pollution. This article assesses pre-session submissions from the second and third negotiation rounds to identify proposed measures and priorities for the treaty. The analysis, employing systematic qualitative content analysis, focuses on the comprehensiveness of submissions, variations in proposed measures across the plastics value chain and political-economic factors influencing state positions. Results reveal a divergence between ambitious clusters advocating for upstream regulatory measures and less ambitious clusters emphasising downstream waste management. As negotiations progress, countries with vested interests in plastic production are likely to defend their economic positions by advocating for a treaty limited to downstream solutions. This approach risks diluting the treaty’s impact by failing to address production levels, potentially undermining the overarching goal of ending plastic pollution.https://cassyni-user-files-prod.s3.amazonaws.com/QHn9seX1StyPU2WX8VMP2E https://cassyni.com/events/SFjeD5PAHWrWZp3xaHu6A1/seminar/qa https://cassyni.com/slides/outline/SFjeD5PAHWrWZp3xaHu6A1 https://cassyni.com/events/SFjeD5PAHWrWZp3xaHu6A1/abstract https://cassyni-user-files-prod.s3.amazonaws.com/3qn61AeXvS1Lom3yyqLiJA https://cassyni.com/events/SFjeD5PAHWrWZp3xaHu6A1?videoPreview=1 Giant Tunneling Magnetoresistance Based on Spin-Valley-Mismatched Materialsnohttps://cassyni.com/events/SFjeD5PAHWrWZp3xaHu6A1?videoPreview=12026-04-27T08:30:00+00:002735.52Advanced Physics Research JournalHalf metals, which are amenable to perfect spin filtering, can be utilized for high-magnetoresistive devices. However, available half metals are very limited. Here, we demonstrate that materials with intrinsic spin-valley-mismatched (SVM) states can be used to block charge transport, resembling half metals and leading to giant tunneling magnetoresistance. As an example, by using first-principles transport calculations, we show that ferromagnetic 1T-VSe2, 1T-VS2, and 2H-VS2 are such spin-valley-mismatched metals, and giant pessimistic magnetoresistance of more than 99% can be realized in spin-valve van der Waals (vdW) junctions using these metals as electrodes. Another example is the altermagnet KV2Se2O. We show that magnetic tunnel junctions using the metallic KV2Se2O as the electrodes and few-layer MgO as the spacer exhibit zero-bias magnetoresistance larger than 99%, which is robust against the bias and thickness of the spacer. Owing to the intrinsic mismatch of spin states, the central-layer materials for the vdW junctions can be arbitrary nonmagnetic materials, in principle. Our research provides clear physical insights into the mechanism for high magnetoresistance and opens new avenues for the search and design of high-magnetoresistance devices.https://cassyni-user-files-prod.s3.amazonaws.com/3qn61AeXvS1Lom3yyqLiJA https://cassyni.com/events/5WWGGND7rHbFRpbgJAykGV/seminar/qa https://cassyni.com/slides/outline/5WWGGND7rHbFRpbgJAykGV https://cassyni.com/events/5WWGGND7rHbFRpbgJAykGV/abstract https://cassyni-user-files-prod.s3.amazonaws.com/KesFSftzyxbZzdV8WjWEtv https://cassyni.com/events/5WWGGND7rHbFRpbgJAykGV?videoPreview=1 Open Science for Better Nutrition Research: Improving Research Standards Through Data Sharing, Transparent Reporting, and Author Identificationnohttps://cassyni.com/events/5WWGGND7rHbFRpbgJAykGV?videoPreview=12026-05-14T16:00:00+00:003591.16The Nutrition SocietyScientific publishing is facing multiple existential challenges around integrity, validity and volume. Some of these challenges are particularly acute in Nutrition Science. Adoption of Open Science and Open Research is widely regarded as a route to improve integrity, transparency and auditability of science in general. Whilst some disciplines lend themselves to these practices, nutrition has been slow to transition. As part of its mission, *Journal of Nutritional Science* is progressively adopting and expecting open science principles in its delivery. This webinar draws together a series of experts to showcase how changes can be effective and transformative to the science that we conduct and report. The speakers will aim to demystify and make accessible simple changes that can lead to robust, reproducible and credible science. The session is aimed at nutrition researcher and institutions interested in raising standards across the discipline. Talks include: **Open Data and data deposition, how can nutrition journals and academic institutions do this better.** This presentation will provide recommendations for how to shift the current paradigm of data ownership to data sharing. The intention of this presentation is to provide a framework for how to expand access to research data, provide ethical guidelines for data sharing, and incentivize data sharing at academic institutions. The presentation is the result of previous working groups from two 2025 symposia at IUNS-ICN and a FENS Northern Task Force webinar. **CONSORT-Nut: an extension of the CONSORT 2025 statement for reporting nutrition trials** There is substantial evidence that trials in nutrition are not reported appropriately. Incomplete reporting wastes resources, which may lead to mixed findings and limited replicability. Readers who rely on incomplete research reports may arrive at erroneous conclusions when making research, clinical, or policy decisions. Incomplete reporting may also risk simplistic or incorrect conclusions by journalists thereby potentiating confusion and low trust in nutrition science by a lay audience. Yet, poor or incomplete reporting of research findings can be avoided. The present guideline, called “CONSORT-Nut”, is an extension of the CONSORT (CONsolidated Standards Of Reporting Trials) [2025 statement for reporting of RCTs](https://doi.org/10.1136/bmj-2024-081124). The guideline paper which includes 9 nine nutrition-specific recommendations, along with examples and explanations, is currently under review. It is the culmination of a 5 year process coordinated by an international researcher group, which is described in our 3 previous papers: * [doi.org/10.1007/s00394-024-03561-1](https://doi.org/10.1007/s00394-024-03561-1) * [doi.org/10.1016/j.advnut.2023.100154](https://doi.org/10.1016/j.advnut.2023.100154) * [doi.org/10.1007/s00394-023-03137-5](https://doi.org/10.1007/s00394-023-03137-5) https://cassyni-user-files-prod.s3.amazonaws.com/KesFSftzyxbZzdV8WjWEtv https://cassyni.com/slides/outline/UivRDEb1g5mVxaNVdk37LR https://cassyni.com/events/UivRDEb1g5mVxaNVdk37LR/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Nt1CYbiwYSnA88MUBx7MVQ https://cassyni.com/events/UivRDEb1g5mVxaNVdk37LR?videoPreview=1 Explainable deep learning for control and foundation models for discovery and optimizationnohttps://cassyni.com/events/UivRDEb1g5mVxaNVdk37LR?videoPreview=12026-03-19T18:30:00+00:003953.96AI Institute in Dynamic SystemsIn this seminar we discuss a unified framework that combines explainable deep learning, deep reinforcement learning (DRL) and foundation models to advance both understanding and control of turbulence, with direct implications for accelerated design and discovery. First, we will show how explainable deep learning techniques can be used to identify the flow features that are truly responsible for key turbulent processes in wall-bounded flows. By systematically interrogating trained neural networks, we uncover the most influential coherent structures driving momentum transport and drag. Our results reveal that classically studied structures (while important) provide only a partial and sometimes misleading perspective, motivating a more data-driven and physics-aware view of turbulence organization. Building on these insights, we will demonstrate how deep reinforcement learning can be used to actively control turbulent flows by targeting the dynamically relevant structures identified through explainability. This approach achieves over 30% drag reduction in canonical wall-bounded turbulence and extends naturally to more complex configurations, including turbulent wings, highlighting the scalability of learning-based control strategies. Finally, we will introduce a foundation-model-based framework for accelerated design, optimization and scientific discovery. By learning compact, interpretable latent representations of high-dimensional flow physics, these models (combined with agentic-AI systems) enable rapid exploration of design spaces, causal reasoning and closed-loop optimization, bridging the gap between expensive simulations, control and engineering decision making. Together, these results illustrate how explainable and agentic AI are becoming essential for turbulence physics, flow control and next-generation engineering design.https://cassyni-user-files-prod.s3.amazonaws.com/Nt1CYbiwYSnA88MUBx7MVQ https://cassyni.com/slides/outline/TjdD7sHxoAfMHpYVXmZnXX https://cassyni.com/events/TjdD7sHxoAfMHpYVXmZnXX/abstract https://cassyni-user-files-prod.s3.amazonaws.com/G2FshtJtCpFDXZHBoJfkna https://cassyni.com/events/TjdD7sHxoAfMHpYVXmZnXX?videoPreview=1 Simulation-Based Design of Composite Aircraft Wings: Towards a Data-Assisted FSI Frameworknohttps://cassyni.com/events/TjdD7sHxoAfMHpYVXmZnXX?videoPreview=12026-07-15T10:00:00+00:002731.36Department of AeronauticsThe application of carbon fiber-reinforced plastics (CFRP) is essential for developing lightweight and aerodynamically efficient next-generation aircraft wings. This presentation introduces a comprehensive multidisciplinary design optimization (MDO) framework that integrates computational fluid dynamics (CFD), structural finite element methods (FEM), and multiscale material modeling for transonic aircraft wings. We performed a global multi-objective optimization to systematically explore trade-offs between aerodynamic drag and structural weight across various carbon fibers (e.g., T700S, T800S, and T1100G). We demonstrated that stiffer fibers significantly reduce wing twist deformation and overall structural weight. Furthermore, we evaluated the impacts of two-way aeroelastic coupling and geometrical nonlinearity, which are critical for accurately sizing highly flexible composite wings. The framework also incorporates continuum damage mechanics (CDM) to assess damage tolerance, revealing that fiber breakage severely compromises safety margins, whereas transverse matrix cracking has negligible effects. Finally, to address the high computational costs of these iterative coupled simulations, we are developing a data-assisted FSI framework. Specifically, we will highlight a recent study (10.1016/j.jfluidstructs.2026.104636) for an interface control principle on dynamic FSI and deep Koopman models to efficiently predict and optimize complex aeroelastic behaviors.https://cassyni-user-files-prod.s3.amazonaws.com/G2FshtJtCpFDXZHBoJfkna https://cassyni.com/slides/outline/6VkE8UUPvUr3A4ZKfDMeNh https://cassyni.com/events/6VkE8UUPvUr3A4ZKfDMeNh/abstract https://cassyni-user-files-prod.s3.amazonaws.com/HTxrbbs9MuJh7UzhGG4fqY https://cassyni.com/events/6VkE8UUPvUr3A4ZKfDMeNh?videoPreview=1 Energy Adaptation Strategiesnohttps://cassyni.com/events/6VkE8UUPvUr3A4ZKfDMeNh?videoPreview=12018-11-15T06:00:00+00:001531.08 School of Public PolicyThe global energy system is undergoing transformation through the decarbonization of electricity and the electrification of transportation. This dual shift presents challenges for grid resilience, especially with increasing penetration of variable renewable electricity, leading to issues such as the "duck curve" and shifting peak demands across geographical areas. This study explores grid-integrated electric vehicles (EVs) as a novel adaptation strategy to enhance grid resilience. The approach involves leveraging EVs for two primary functions: smart coordinated charging to balance demand fluctuations (e.g., filling valleys and clipping peaks) and vehicle-to-grid (V2G) services. V2G services, which could potentially offer EV owners $650-$1200 annually for frequency regulation, include capacity firming, voltage control, and providing reserves. EVs also offer potential as emergency backup power. Currently, 535,000 EV charging cycles are managed, and while distributed solar accounts for ~1% (14 GW) of U.S. generating capacity and combined heat and power ~8% (80 GW), the potential contribution from EVs is substantial. For instance, 100,000 EVs, each offering 5 kW, could provide 500 GW of capacity, significantly exceeding the projected 20 GW of utility-scale storage by mid-century. Effective scaling of this opportunity requires various stakeholders—vehicle owners (particularly fleet managers), original equipment manufacturers, non-utility market aggregators, and utilities—to define their roles and develop new business models. Several states are already promoting energy storage through mandates and incentives. The integration of EVs and electricity infrastructure offers a complementary pathway for renewables, making the grid more resilient and accelerating decarbonization, while also highlighting the importance of addressing equity concerns in energy transitions globally and domestically.https://cassyni-user-files-prod.s3.amazonaws.com/HTxrbbs9MuJh7UzhGG4fqY https://cassyni.com/events/6zPqBA7vMwQ69q6DFeeSe1/abstract https://cassyni-user-files-prod.s3.amazonaws.com/LNtjTsxX9NGZxryyCVPpXg https://cassyni.com/slides/outline/BSEGbJweK4PLcUr1AJR1nV https://cassyni.com/events/BSEGbJweK4PLcUr1AJR1nV/abstract https://cassyni-user-files-prod.s3.amazonaws.com/H58gYg2WJKyuEeAThgsAvS https://cassyni.com/events/BSEGbJweK4PLcUr1AJR1nV?videoPreview=1 Liberata: Incentivizing Peer Review and Replication (Lightning Talk)nohttps://cassyni.com/events/BSEGbJweK4PLcUr1AJR1nV?videoPreview=12026-02-24T15:35:00+00:00366.12Researcher to ReaderAcademic publishing lacks incentive-aligned quality control and relies on author order and journal brands as proxies for contribution and rigor. Liberata is an open access academic publishing platform that assigns contribution shares to authors on papers, which can subsequently be traded in academic marketplaces for incentivized peer review and replication.https://cassyni-user-files-prod.s3.amazonaws.com/H58gYg2WJKyuEeAThgsAvS https://cassyni.com/events/JMLMMWWsrq4rFmXypJvPZo/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Ai2fqo6ygMCFMmK1sNFtte https://cassyni.com/slides/outline/VDbeNYkRWuFKn3N1RrA5Wd https://cassyni.com/events/VDbeNYkRWuFKn3N1RrA5Wd/abstract https://cassyni-user-files-prod.s3.amazonaws.com/DM1ihjaSvo6S2boNVa3Ep6 https://cassyni.com/events/VDbeNYkRWuFKn3N1RrA5Wd?videoPreview=1 H6 – Building a Modern Research Analytics Ecosystem with Microsoft Fabric: Dataflows, Lakehouses, and Semantic Modelsnohttps://cassyni.com/events/VDbeNYkRWuFKn3N1RrA5Wd?videoPreview=12026-04-21T12:30:00+00:002693.12Research Analytics SummitResearch administration depends on data from multiple systems including proposal submissions, awards, HR, finance, and compliance. Microsoft Fabric provides a unified platform that streamlines how data is ingested, transformed, stored, and delivered for reporting. This session focuses on three core Fabric capabilities that strengthen Research Analytics: Dataflows for Extract, Transform, Load (ETL), Lakehouses for centralized and scalable storage, and Semantic Models for consistent, enterprise – wide reporting. The session will demonstrate how to pull and transform data from systems such as Cayuse, Snowflake, and SharePoint/OneDrive using low – code automation tools within Microsoft Fabric, including Dataflows Gen2. Attendees will see how Fabric Lakehouses act as a single, trusted data foundation where raw data can be cleaned, organized, and prepared for analysis. The session will also highlight how Semantic Models standardize KPIs, reduce duplication, and power dashboards for proposals, awards, faculty activity, and public impact reporting through examples from a Research Office environment. Attendees will learn how to leverage Microsoft Fabric’s intuitive interface to structure research data pipelines, automate refresh cycles, and apply governance practices to maintain data quality and reproducibility. Because many organizations already have access to Fabric through Microsoft licensing, these techniques will be broadly applicable and enable attendees to modernize analytics.https://cassyni-user-files-prod.s3.amazonaws.com/DM1ihjaSvo6S2boNVa3Ep6 https://cassyni.com/events/9TfUXCsRxb6g51MxQidMEm/seminar/qa https://cassyni.com/events/9TfUXCsRxb6g51MxQidMEm/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Jvqe51RPu51Usr9m9EbkZt https://cassyni.com/slides/outline/GsRAL66BwpLEi4apfARXHP https://cassyni.com/events/GsRAL66BwpLEi4apfARXHP/abstract https://cassyni-user-files-prod.s3.amazonaws.com/PNeobHNTyuLFo7eahVHt2z https://cassyni.com/events/GsRAL66BwpLEi4apfARXHP?videoPreview=1 Learning stochastic models of living matternohttps://cassyni.com/events/GsRAL66BwpLEi4apfARXHP?videoPreview=12026-04-09T18:00:00+00:004186.52AI Institute in Dynamic SystemsRecent advances in experimental live-imaging techniques have enabled simultaneous measurements of physical and biological observables at unprecedented spatial and temporal resolutions. Prominent examples range from recordings of gene-expression dynamics in growing microbial communities to complex neuro-mechanical behaviors in higher organisms. One of the key challenges in the coming years will be translating these high-dimensional multiscale data into low-dimensional mathematical models that can help classify complex biological phenomena within and across species and reveal the underlying biophysical and biochemical mechanisms. In this talk, I will survey recent joint efforts with our experimental partner labs to understand the behavioral complexity of algae, worms, mosquitoes and other organisms by combing spectral representations with dynamical systems learning approaches.https://cassyni-user-files-prod.s3.amazonaws.com/PNeobHNTyuLFo7eahVHt2z https://cassyni.com/slides/outline/XgsHibVw7YwaxgJCBCtt9T https://cassyni.com/events/XgsHibVw7YwaxgJCBCtt9T/abstract https://cassyni-user-files-prod.s3.amazonaws.com/2hnZ7TrsjV6o9M7rNeTRC2 https://cassyni.com/events/XgsHibVw7YwaxgJCBCtt9T?videoPreview=1 Episode 10: A Conversation with Yi Yenohttps://cassyni.com/events/XgsHibVw7YwaxgJCBCtt9T?videoPreview=12026-01-11T09:00:00+00:002217.72Advanced ScienceOral cancer pain significantly impacts patient quality of life and daily functions, with most individuals presenting late in disease progression. Early cancer often lacks pain, suggesting cancer cells actively modulate nociceptive alarm systems. This research investigates the complex and evolving nature of oral cancer pain and its underlying mechanisms. The approach involves detailed patient pain phenotyping using established and newly developed questionnaires, capturing multifocal pain, diverse sensory experiences (e.g., numbness, burning, food sensitivities to sour, spicy, or rough textures), and its evolution over time. Quantitative sensory testing demonstrated a positive correlation with subjective pain reports. Mechanistically, cancer cells were found to release increased pro-nociceptive signals, including pro-inflammatory cytokines and toxic lipids, which may activate or sensitize nociceptors. Key findings indicate that pain intensity correlates with decreased sleep quality, with spontaneous pain predicting poorer sleep. A prospective study in 118 patients revealed that pre-treatment pain is a predictor of post-treatment pain. The study also addresses comorbidities, such as depression and anxiety, and acknowledges biological sex differences in pain, observed in animal models via distinct nociceptor and glial cell responses, though clinical cohorts showed only a tendency for higher female-reported intensity without statistical significance due to male predominance in oral cancer. Future directions highlight the integration of wearable devices and AI/machine learning for enhanced data analysis and improved pain segmentation, underscoring the necessity of interdisciplinary research for comprehensive understanding and management of cancer pain.https://cassyni-user-files-prod.s3.amazonaws.com/2hnZ7TrsjV6o9M7rNeTRC2 https://cassyni.com/slides/outline/23y2wagSn5icQ8J7eWbnjf https://cassyni.com/events/23y2wagSn5icQ8J7eWbnjf/abstract https://cassyni-user-files-prod.s3.amazonaws.com/8Dtk4CYQXwGQarPuD3xLHU https://cassyni.com/events/23y2wagSn5icQ8J7eWbnjf?videoPreview=1 Black-Owned Business Equity in the Covid-19 Eranohttps://cassyni.com/events/23y2wagSn5icQ8J7eWbnjf?videoPreview=12025-11-19T18:30:00+00:00961.44Center for Black Entrepreneurship, Spelman CollegeThe COVID-19 pandemic led to an increased focus on Black-owned business growth, with initial data from the Survey of Consumer Finances (SCF) indicating an increase in the proportion of Black households reporting business equity from 4.8% to 11% between 2019 and 2022. However, this growth in ownership coincided with a substantial decline in the median business equity value for Black households, which fell from $81,000 to $42,000. In contrast, White households experienced only a slight decrease in median business equity, from $115,000 to $105,000. This study utilized longitudinal data from the Panel Study of Income Dynamics (PSID) to track changes in business equity for the same households over time. A propensity score kernel-matching strategy was employed to construct statistically comparable groups of Black and White business owners, controlling for various demographic and business characteristics. The analysis revealed that among households with business equity in 2019, the mean equity for White households was $119,000, compared to $24,000 for Black households. Between 2019 and 2021, White households experienced a 47% increase in equity value, with a sustained 26% growth through 2023. In stark contrast, Black households with existing business equity faced a 37% decline in value from 2019 to 2021, a loss that remained substantial at 28% by 2023. Even after matching for business owner characteristics, a statistically significant negative difference in equity change persisted, demonstrating that Black business owners lost more equity than White business owners both during and after the pandemic, a finding not solely explained by business attrition. This research highlights the urgent need for proactive, equitably designed policy interventions that consider wealth outcomes in crisis responses, addressing historical disparities in access to support programs like the Paycheck Protection Program.https://cassyni-user-files-prod.s3.amazonaws.com/8Dtk4CYQXwGQarPuD3xLHU https://cassyni.com/slides/outline/CvEKxcuzS9u5vQ89G3qUgV https://cassyni.com/events/CvEKxcuzS9u5vQ89G3qUgV/abstract https://cassyni-user-files-prod.s3.amazonaws.com/NyRiurhHu4AbAG9QVXyGMU https://cassyni.com/events/CvEKxcuzS9u5vQ89G3qUgV?videoPreview=1 The Third Forum on Recent Research in Gender and Ming-Qing Culturenohttps://cassyni.com/events/CvEKxcuzS9u5vQ89G3qUgV?videoPreview=12021-12-10T06:00:00+00:0010950.88Hong Kong Baptist UniversityJointly organized by the Department of History, Jao Tsung-I Academy of Sinology, Mr Simon Suen and Mrs Mary Suen Sino-Humanitas Institute, and the Gender Studies Concentration, the Third Forum on Recent Research in Gender and Ming-Qing Culture was held online on 10 December, 2021 (HKT) with distinguished speakers from five different time zones. Convened by Prof Clara Ho (HIST) and Prof Hongsheng Zhang (SHI), the first and second Forum were held face-to-face in 2015 and 2017 respectively. The Conveners have moved the third Forum online to feature 22 senior international scholars from renowned institutions in USA (Stanford, UCs, Tufts, Wellesley, Michigan, Wisconsin Madison, Rice, Cal State), Canada (McGill), China (Renmin), Taiwan (Academic Sinica, NTU, NCCU, and NCU) and Hong Kong (HKU, HKBU), who shared their latest research topics in Ming-Qing Gender Culture with nearly 300 participants in a lively virtual conversation. The Forum was livestreamed on YouTube and has reached over 200 views within five days after it was delivered. The Forum was a star-studded event with gender scholars who focus on history, literature, arts, religion, law, medicine, etc. Through this online forum, scholars introduced their latest research projects with unique and insightful perspectives. The success of the event not only demonstrated the rich aspects on gender research but also provide new vision to young scholars and students interested in Ming-Qing China.https://cassyni-user-files-prod.s3.amazonaws.com/NyRiurhHu4AbAG9QVXyGMU https://cassyni.com/slides/outline/FPUMC39cdSfaHLbhojk7QR https://cassyni.com/events/FPUMC39cdSfaHLbhojk7QR/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Rca7fZaDWGtdYeEbN3CPGi https://cassyni.com/events/FPUMC39cdSfaHLbhojk7QR?videoPreview=1 Advances in Archaeological Practice: Inspiration from California nohttps://cassyni.com/events/FPUMC39cdSfaHLbhojk7QR?videoPreview=12026-05-14T16:00:00+00:002359.64NoneFollowing the annual meeting of the Society for American Archaeology in San Francisco, we're bringing together participants in the California sessions with some authors of our most impactful papers on California archaeology in Advances in Archaeological Practice. We'll be discussing our online collection of papers entitled "Inspiration from California" and sharing insights about where California archaeology has been, where it's going, what specific challenges face archaeologists working in California, and what the rest of the world can learn from archaeology in and of the Golden State. Speakers include Kaitlin Brown (author of "Training for Transformation: Building a Responsive Archaeological Workforce in California and Beyond"), Peter Nelson (author of "The Role of GPR in Community-Driven Compliance Archaeology with Tribal and Non-tribal Communities in Central California"), David Robinson (author of "Computational Photography, 3-D Modeling, and Online Publication of Basketry for Cache Cave, California"), Amy Mackinnon (chair of the SAA Session "California High-Speed Rail Cultural Resources Investigations), and Jen Faux-Campbell (chair of the SAA Session "Archaeology for the Present in California").https://cassyni-user-files-prod.s3.amazonaws.com/Rca7fZaDWGtdYeEbN3CPGi https://cassyni.com/events/TF4UR5C6ZntPPMACvfvBph/seminar/qa https://cassyni.com/slides/outline/TF4UR5C6ZntPPMACvfvBph https://cassyni.com/events/TF4UR5C6ZntPPMACvfvBph/abstract https://cassyni-user-files-prod.s3.amazonaws.com/PsFCFKbEr1WjJfQKnyW2Uv https://cassyni.com/events/TF4UR5C6ZntPPMACvfvBph?videoPreview=1 A unique DEM-based coupled 3D thermo-hydro-mechanical mesoscopic model incorporating phase changesnohttps://cassyni.com/events/TF4UR5C6ZntPPMACvfvBph?videoPreview=12026-07-10T11:00:00+00:005071.76Granular MatterA novel DEM-based pore-scale 3D thermo-hydro-mechanical (THM) model of two-phase fluid flow and heat transfer in fluids and solids was employed to investigate the behavior of cohesive-frictional materials (such as concrete, rocks) at the meso-scale. Heat transfer was governed by fluid dynamics (diffusion and advection), cohesive granular particles (conduction), and phase changes. A direct numerical simulation approach, incorporating two coexisting domains: the three-dimensional discrete (solid) domain and the three-dimensional continuous (fluid) domain, was used. Both 3D domains were partitioned into a coarse tetrahedral mesh. The DEM-based THM model was implemented in the open-source software package YADE, using the soft-particle technique. The calibration was performed using single numerical tests (mechanical, hydrological, and thermal). The efficacy of the THM model was initially demonstrated by a thermal contraction test on a particle assembly during cooling, leading to the formation of a macro-crack. The coupled numerical computations examined the impacts of strain rate, particle fragmentation, fluid saturation, fluid viscosity, and temperature during loading. To simulate intra-granular fragmentation of aggregates, a clump breakdown approach was used. The numerical results were directly compared with relevant experiments documented in the literature. An acceptable agreement was achieved. The 3D results were also compared with the 2D ones.https://cassyni-user-files-prod.s3.amazonaws.com/PsFCFKbEr1WjJfQKnyW2Uv https://cassyni.com/slides/outline/HN6PVQFbndp4XqABR79pgm https://cassyni.com/events/HN6PVQFbndp4XqABR79pgm/abstract https://cassyni-user-files-prod.s3.amazonaws.com/PsJQdy1zRMtQ9Khv88N8rr https://cassyni.com/events/HN6PVQFbndp4XqABR79pgm?videoPreview=1 Building AI Climate Models for Scientific Discovery nohttps://cassyni.com/events/HN6PVQFbndp4XqABR79pgm?videoPreview=12026-05-28T18:00:00+00:003728.48AI Institute in Dynamic SystemsScientists use computer simulations to understand how different parts of the Earth’s system interact, or to explore how they respond to external forcing. These simulations have been carried out using numerical models (global climate models, or GCMs). Recently, modern machine-learning-based emulators have been used to reproduce the same dynamics using data. I will present the first-generation AI digital twin of the climate system, using data from state-of-the-art GCMs. These AI emulators can simulate the climate system 100x faster than typical GCMs on a single GPU. We will discuss how we build, evaluate, and leverage these emulators to make discoveries about the climate system. https://cassyni-user-files-prod.s3.amazonaws.com/PsJQdy1zRMtQ9Khv88N8rr https://cassyni.com/events/33Hs9aVP4MkVDfQMztctQM/seminar/qa https://cassyni.com/slides/outline/33Hs9aVP4MkVDfQMztctQM https://cassyni.com/events/33Hs9aVP4MkVDfQMztctQM/abstract https://cassyni-user-files-prod.s3.amazonaws.com/TwRMi5PNokFSPhjU7zfBrW https://cassyni.com/events/33Hs9aVP4MkVDfQMztctQM?videoPreview=1 Contact-network structure under shear and its influence on particle motion in dense suspensionsnohttps://cassyni.com/events/33Hs9aVP4MkVDfQMztctQM?videoPreview=12026-06-18T13:00:00+00:005082.32Granular MatterWe investigate discontinuous shear-thickening (DST) and the approach to shear jamming (SJ) in dense, non-Brownian suspensions composed of monodisperse and bidisperse particles, with size ratios up to 4:1. Simulations are performed using the Lubrication Flow-Discrete Element Method (LF-DEM), a well-established framework that combines hydrodynamic lubrication interactions with discrete particle contacts, incorporating frictional contact forces that activate above a critical stress threshold. The analysis presented here focuses on evolution with stress and solid fraction of the frictional contact networks and their coupling to particle-scale dynamics, particularly translational and rotational fluctuations and their correlations. As jamming is approached, rotational motion becomes strongly correlated over long distance, signaling the emergence of collective dynamics linked to the formation of system-spanning contact structures. To probe the origins of this behavior, we examine the onset of contact percolation and the development of rigidity through geometric and topological measures of the network. The particle dynamics and mechanism of motion near jamming is explored by considering different measures of the contact network, including percolation of structures with varying numbers of contacts as well as structures identified by a “pebble game” as transient rigid clusters that appear in this regime; as an example of the structural consequences, we find that the PG rigid cluster appearance follows critical behavior, with consequent large fluctuations in viscosity, and is shown to be a precursor to jamming. https://cassyni-user-files-prod.s3.amazonaws.com/TwRMi5PNokFSPhjU7zfBrW https://cassyni.com/slides/outline/QmpTBexUNW7u2QgeNz1Z6m https://cassyni.com/events/QmpTBexUNW7u2QgeNz1Z6m/abstract https://cassyni-user-files-prod.s3.amazonaws.com/SNSWZxjuWkKeKX6aDWTpuU https://cassyni.com/events/QmpTBexUNW7u2QgeNz1Z6m?videoPreview=1 Ancient landscapes, modern genomes: reading the geological past to interpret the genetic presentnohttps://cassyni.com/events/QmpTBexUNW7u2QgeNz1Z6m?videoPreview=12026-05-15T02:15:00+00:003327.04Institute for Applied EcologyPhylogeographic patterns in Australia's biota are rich with signal, but that signal is only interpretable against the backdrop of a dramatically transformed continent. I will talk about how deep geological and climatic history has shaped the genetic architecture of Australian fauna, with a focus on two contrasting systems: the arid zone and the Australian alps. From the vast fluvial networks that once crossed active dunefields, to the glacially sculpted highlands of the southeast, the landscapes that taxa inhabit today bear little resemblance to those in which their evolutionary histories unfolded. The Last Glacial Maximum (LGM) remade the continent: distributions shifted, environments vanished and reappeared, and lineages adapted, persisted, or were lost entirely. And yet much of what has been recorded in the genetics of the organisms we study in Australia is often far older than the LGM. Without this deep paleogeographic context, our genomic inferences risk profound misinterpretation.https://cassyni-user-files-prod.s3.amazonaws.com/SNSWZxjuWkKeKX6aDWTpuU https://cassyni.com/slides/outline/7ymucQxdSwHWcm7i1NKt8V https://cassyni.com/events/7ymucQxdSwHWcm7i1NKt8V/abstract https://cassyni-user-files-prod.s3.amazonaws.com/21SLoWdGh64r93tst6pCei https://cassyni.com/events/7ymucQxdSwHWcm7i1NKt8V?videoPreview=1 Recent progresses in laser ion acceleration thanks to innovative targets and new interaction regimesnohttps://cassyni.com/events/7ymucQxdSwHWcm7i1NKt8V?videoPreview=12026-05-28T15:00:00+00:002958.96Journal of Plasma PhysicsLaser ion acceleration has emerged as a promising, compact, and cost-effective alternative to conventional ion accelerators. Significant progress has been made over the past decade, with proton beams reaching 160 MeV in experiments at the HZDR in Germany using the DRACO laser, and the development of innovative new targets as well as the exploration of new interaction regimes. After introducing the main mechanisms of ion acceleration in laser-plasma interaction with short, intense lasers, the latest advances in this field will be reviewed. The potential of gas jets, helical targets, and cryogenic targets for improving the characteristics of laser-accelerated ions will be discussed. Applications of these ion sources to the production of neutrons, and to the production of radio-isotopes will also be addressed.https://cassyni-user-files-prod.s3.amazonaws.com/21SLoWdGh64r93tst6pCei https://cassyni.com/events/CRcM2ZnMQ4Gm5QsVv26TGy/seminar/qa https://cassyni.com/slides/outline/CRcM2ZnMQ4Gm5QsVv26TGy https://cassyni.com/events/CRcM2ZnMQ4Gm5QsVv26TGy/abstract https://cassyni-user-files-prod.s3.amazonaws.com/eWrk9U8Z813b7tV2Dze3p https://cassyni.com/events/CRcM2ZnMQ4Gm5QsVv26TGy?videoPreview=1 Interpretable Graph Spectral Processing and Analysis for Geometric Data and Beyondnohttps://cassyni.com/events/CRcM2ZnMQ4Gm5QsVv26TGy?videoPreview=12026-06-25T12:00:00+00:002957.04Journal on Image and Video ProcessingGeometric data acquired from real-world scenes, e.g., 2D depth images, 3D point clouds, and 4D dynamic point clouds, have found a wide range of applications including autonomous driving, augmented and virtual reality, surveillance, etc. Due to irregular sampling patterns of most geometric data, traditional image/video processing methodologies are limited, while Graph Signal Processing (GSP)—a fast-developing field in the signal processing community—enables processing signals that reside on irregular domains. Further, GSP provides insightful spectral interpretations and domain knowledge for the recently developed Graph Neural Networks (GNNs), leading to interpretability and robustness of GNNs. In this talk, I will introduce our recent research projects to illustrate the power of graph spectral processing and analysis in terms of geometric structure learning, unsupervised graph representation learning and interpretable analysis via GSP-based prior knowledge. Beyond geometric data, I will also introduce our interpretable and lightweight transformer design for brain signals via balanced signed graph algorithm unrolling.https://cassyni-user-files-prod.s3.amazonaws.com/eWrk9U8Z813b7tV2Dze3p https://cassyni.com/slides/outline/PHuGAEXnTVNxkAPvp8GarR https://cassyni.com/events/PHuGAEXnTVNxkAPvp8GarR/abstract https://cassyni-user-files-prod.s3.amazonaws.com/883ti9HNRryb7o9at6mhHG https://cassyni.com/events/PHuGAEXnTVNxkAPvp8GarR?videoPreview=1 Sono-Mechanogenetics: Linking Ultrasound Physics with Cellular Mechanobiologynohttps://cassyni.com/events/PHuGAEXnTVNxkAPvp8GarR?videoPreview=12026-06-11T13:00:00+00:001469.72Advanced OncologyThis webinar discusses what sono-mechanogenetics is and the application of this novel technology in oncology and beyond.https://cassyni-user-files-prod.s3.amazonaws.com/883ti9HNRryb7o9at6mhHG https://cassyni.com/slides/outline/WCyioob8bu8kEyPWBZqX17 https://cassyni.com/events/WCyioob8bu8kEyPWBZqX17/abstract https://cassyni-user-files-prod.s3.amazonaws.com/2zaBu9MTGosHWAzz6dnJJz https://cassyni.com/events/WCyioob8bu8kEyPWBZqX17?videoPreview=1 Coping with extreme heat: drivers of variation in plant physiological tolerancenohttps://cassyni.com/events/WCyioob8bu8kEyPWBZqX17?videoPreview=12026-06-02T15:00:00+00:001908.24Understanding the vulnerability of plant species and communities to heat extremes is an urgent priority for plant ecologists and land managers alike. Key morphological plant traits associated with thermal protection vary across environments, often underpinned by phylogeny. We therefore might expect that physiological traits, such as critical temperatures for photosynthetic function, would likewise vary across contrasting biomes and/or taxonomic groups. A global focus on plant thermal tolerance research over recent years suggests that the story is more complex. While biome of origin can explain a certain amount of variation in physiological heat tolerance, more often such patterns are weak or absent, especially under common garden settings. Likewise, higher level phylogeny – genus, family – rarely strengthens predictive models, whereas species routinely explains a major proportion of variation in heat tolerance. Adding to these challenges is the wide variation in response within species. For example, timing of measurement can be a strong influence, both at micro (time of day, pre/post treatment) and macro (date, season) scales, generally associated with environmental acclimation. To fill key knowledge gaps, research efforts must focus on the cost of acclimation, how this changes with increased temperatures, how such costs in turn affect recovery and ultimately, reproductive fitness.https://cassyni-user-files-prod.s3.amazonaws.com/2zaBu9MTGosHWAzz6dnJJz https://cassyni.com/slides/outline/WhdKrVEf3MgoEjvPn18KGR https://cassyni.com/events/WhdKrVEf3MgoEjvPn18KGR/abstract https://cassyni-user-files-prod.s3.amazonaws.com/2d5z7dcowiTFvensdandga https://cassyni.com/events/WhdKrVEf3MgoEjvPn18KGR?videoPreview=1 A stocktake: how well can we predict effects of extreme heat on plant photosynthesis, water use and growth?nohttps://cassyni.com/events/WhdKrVEf3MgoEjvPn18KGR?videoPreview=12026-06-03T14:45:00+00:001889.56This talk will review the current state-of-the-art in modelling effects of extreme heat on plant performance. I will first review our increasing understanding of the short-term effects of high temperatures on plant photosynthesis, stomatal behaviour and leaf damage, and how these effects are being incorporated into models of leaf physiology. I will then examine the implications of these short-term responses for plant growth over the longer term, using the dynamic vegetation model LPJ-GUESS to illustrate the sensitivities of plant growth. The talk will finish with a research agenda to improve model capacity to predict the effects of future extreme heatwaves.https://cassyni-user-files-prod.s3.amazonaws.com/2d5z7dcowiTFvensdandga https://cassyni.com/events/8UT8mj83HkmLSE7DoUSrJh/seminar/qa https://cassyni.com/slides/outline/8UT8mj83HkmLSE7DoUSrJh https://cassyni.com/events/8UT8mj83HkmLSE7DoUSrJh/abstract https://cassyni-user-files-prod.s3.amazonaws.com/TqBoVrMYMZyxghpt2bviaS https://cassyni.com/events/8UT8mj83HkmLSE7DoUSrJh?videoPreview=1 Analysis of Composite Structures for Certificationnohttps://cassyni.com/events/8UT8mj83HkmLSE7DoUSrJh?videoPreview=12026-07-22T13:00:00+00:003431.04Department of AeronauticsAnalysis supported by test will dominate certification of future composite aerospace products provided such analysis is sufficiently accurate and efficient for Uncertainty Quantification. Failure at the sub-mm scale must be predicted whilst allowing for structural-scale de-stiffening. Standard FEA and Digital Image Correlation are used to calibrate material properties and boundary conditions for the nonlinear response of a simple composite part (pre-damage). A multiscale FEM shows some promise for predicting the onset of damage in this part. However, a new Eigenmode method is proposed which could drastically reduce computation time. The method is applied to the debonding of a thermoplastic joint between a stiffener and a postbuckled skin, with improved accuracy compared with the Cohesive Zone Method. https://cassyni-user-files-prod.s3.amazonaws.com/TqBoVrMYMZyxghpt2bviaS https://cassyni.com/events/AwhA19MfV3Y9XhvLksbazZ/abstract https://cassyni-user-files-prod.s3.amazonaws.com/AA7T2PqX2Dc8XqAY3U4qFC https://cassyni.com/events/6VtLhd3pwHUftkdB3tfBky/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Xs5J1fs4hdzskxF7cwhHdx https://cassyni.com/events/BSNPATX5Ks1yMAurYyiZAm/abstract https://cassyni-user-files-prod.s3.amazonaws.com/JRzwJ9ie8XJNPUqEJ85Svi https://cassyni.com/slides/outline/7VDAucrmDZWYhz9aSS4xCV https://cassyni.com/events/7VDAucrmDZWYhz9aSS4xCV/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Lyq5GpTcNyyz3pNFjgeA9L https://cassyni.com/slides/outline/VDjkwhKrXhsxWjRrpXTctu https://cassyni.com/events/VDjkwhKrXhsxWjRrpXTctu/abstract https://cassyni-user-files-prod.s3.amazonaws.com/7uxsrsoHr6pbkjsCcY7f4S https://cassyni.com/events/VDjkwhKrXhsxWjRrpXTctu?videoPreview=1 HCR • The iSupport Support Model for Dementia Carers in Australianohttps://cassyni.com/events/VDjkwhKrXhsxWjRrpXTctu?videoPreview=12026-08-07T08:00:00+00:003757.04NoneTo further advance academic exchanges and cooperation in global healthcare and rehabilitation, the journal [Healthcare and Rehabilitation (HCR)](https://www.keaipublishing.com/en/journals/healthcare-and-rehabilitation/) is pleased to launch the “Qilu International Academic Lecture on Healthcare and Rehabilitation”. This lecture series aims to build an interdisciplinary, high-quality international exchange platform that brings together top experts and young scholars from around the world to explore the latest research trends and cutting-edge topics in the field. On Aug.07, 2026, Ms. Lily Xiao, Professor at College of Nursing and Health Sciences -- Caring Futures Institute, delivered a report titled The iSupport Support Model for Dementia Carers in Australia. https://cassyni-user-files-prod.s3.amazonaws.com/7uxsrsoHr6pbkjsCcY7f4S https://cassyni.com/events/EtwEbsZdoRpPCZg3QJvgcV/abstract https://cassyni-user-files-prod.s3.amazonaws.com/M5WXnXYkxVVJkoHUgrUsPt https://cassyni.com/events/9Tob6MSryPjJohRooPvtd3/abstract https://cassyni-user-files-prod.s3.amazonaws.com/KvjDUSh3xNNnwxb5e6ESjY https://cassyni.com/events/MpVHC9P3nyKXBBvbfZqoGZ/abstract https://cassyni-user-files-prod.s3.amazonaws.com/YJSyGpaFGCDsedbXTA86RL https://cassyni.com/slides/outline/Gt1EjJuoQPnVn6DFf68oYR https://cassyni.com/events/Gt1EjJuoQPnVn6DFf68oYR/abstract https://cassyni-user-files-prod.s3.amazonaws.com/LESR8sMHj2CaXLYQGCWsfc https://cassyni.com/events/Gt1EjJuoQPnVn6DFf68oYR?videoPreview=1 Fast Turbulence Phase Transition in a Flux-Driven Global Edge-SOL Simulation of a Tokamak Plasmanohttps://cassyni.com/events/Gt1EjJuoQPnVn6DFf68oYR?videoPreview=12026-09-03T15:00:00+00:003063.44Journal of Plasma PhysicsSuppressed turbulent transport is of major interest for the operation of magnetic confinement fusion reactors. The (high confinement) H-mode is routinely accessed on all major tokamaks today and is assumed to be accessible in future devices such as ITER. However, 40 years after its discovery, reactor design still relies on empirical extrapolations. Only recently, first-principles-based predictive simulations of the phenomenon are becoming possible. We approach this challenge with direct numerical simulations using the GRILLIX code [1,2], and more recently also GENE-X [3]. GRILLIX has been validated against the ASDEX Upgrade tokamak under stationary ITER baseline H-mode conditions [2], while L-mode simulations are carried out routinely. Here, we report on a power ramp between the two regimes [1] in a single confinement-time-long simulation (50 ms). After 32 ms of slow profile evolution, a sudden change in transport triggers a pedestal buildup within ∼100 μs, which to our knowledge is reproduced for the first time in a realistic global 3D simulation. This transition results from an abrupt shift from drift-wave (DW) to kinetic-ballooning-mode (KBM) turbulence. The self-consistently evolved E × B flow shear first increases slowly and then sharply. Geodesic acoustic mode and Alfvénic flow oscillations intensify prior to the transition and subsequently die out. This is followed by slow oscillations of the transport and profiles, reminiscent of a dithering I-phase or edge-localized-mode (ELM) cycles observed experimentally. While this study paves the way for a better understanding of confinement regime transitions, we also discuss the clear need to consider dynamic equilibrium evolution, peeling and gyrokinetic instabilities.https://cassyni-user-files-prod.s3.amazonaws.com/LESR8sMHj2CaXLYQGCWsfc https://cassyni.com/events/SkyKeyrJBYrpdcDHAeuAgM/abstract https://cassyni-user-files-prod.s3.amazonaws.com/6Pkew819VQ7X7nXL5C3aSJ https://cassyni.com/slides/outline/FQ4RbFyE627qMNE8ofTPfT https://cassyni.com/events/FQ4RbFyE627qMNE8ofTPfT/abstract https://cassyni-user-files-prod.s3.amazonaws.com/yZuKXpH8mpQsx5qtSkpuL https://cassyni.com/events/FQ4RbFyE627qMNE8ofTPfT?videoPreview=1 Decoding Auxin Biology through New Technologies: From Fundamental Mechanisms to Ideal Plant Architecturesnohttps://cassyni.com/events/FQ4RbFyE627qMNE8ofTPfT?videoPreview=12026-09-02T19:00:00+00:003816.04Advanced ScienceAuxin is a fundamental hormone that orchestrates nearly every aspect of plant growth and development. For decades, the precise biochemical pathways converting tryptophan to indole-3-acetic acid (IAA) remained a central mystery in plant biology. In this lecture, the speaker will discuss the definitive discovery of the YUCCA mediated auxin biosynthesis pathway by his laboratory and its essential role in plant organogenesis. He will further explore how these fundamental discoveries have paved the way for advanced synthetic biology applications. The speaker will highlight the latest technological breakthroughs, including the RUBY reporter system. This system utilizes betalain biosynthesis to provide a visible and non-destructive marker for transformation. He will also discuss innovative CRISPR/Cas9 strategies for generating transgene-free and genetically stable edited crops. These tools are currently revolutionizing both basic research and the engineering of climate-resilient agricultural traits. The lecture will conclude with a vision for the future of Synthetic Plant Architectures. This is a field where precise control over hormonal pathways and genomic regulatory toolboxes enables the design of crops with enhanced yields and environmental adaptability.https://cassyni-user-files-prod.s3.amazonaws.com/yZuKXpH8mpQsx5qtSkpuL https://cassyni.com/events/NKAWMTYTdnoLzev7TfxmSm/abstract https://cassyni.com/events/HrxyT82DSyn23rnj8HjcZb/seminar/qa https://cassyni.com/slides/outline/HrxyT82DSyn23rnj8HjcZb https://cassyni.com/events/HrxyT82DSyn23rnj8HjcZb/abstract https://cassyni-user-files-prod.s3.amazonaws.com/SCukgKu5KP4xhc7rJ4L3nW https://cassyni.com/events/HrxyT82DSyn23rnj8HjcZb?videoPreview=1 No Equations, No Variables, No Space and No Time: Data and the Modeling of Complex Systemsnohttps://cassyni.com/events/HrxyT82DSyn23rnj8HjcZb?videoPreview=12025-12-10T16:00:00+00:003577.0Data-Centric Engineering JournalI will give an overview of a research path in data driven modeling of complex systems over the last 30 or so years – from the early days of shallow neural networks and autoencoders for nonlinear dynamical system identification, to the more recent ML-assisted derivation of data driven “emergent” spaces in which to better learn generative PDE laws and accelerate their solution. In all illustrations presented, I will try to point out connections between the “traditional” numerical analysis we know and love, and the more modern data-driven tools and techniques we now have – and some mathematical questions they hopefully make possible for us to answer.https://cassyni-user-files-prod.s3.amazonaws.com/SCukgKu5KP4xhc7rJ4L3nW https://cassyni.com/events/YBYWsufLxNRQnSsYw9dBYq/abstract https://cassyni-user-files-prod.s3.amazonaws.com/FuxktGD4eDLSxyEoxuMQxn https://cassyni.com/slides/outline/GNrRdHzKiSYzkGdCZTRYtu https://cassyni.com/events/GNrRdHzKiSYzkGdCZTRYtu/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Vd7z8icyewGT1j32YA6DqQ https://cassyni.com/events/GNrRdHzKiSYzkGdCZTRYtu?videoPreview=1 A Panel of Circulating Exosomal sncRNAs Associated with Lung Cancer Risk up to 10 Years in Advancenohttps://cassyni.com/events/GNrRdHzKiSYzkGdCZTRYtu?videoPreview=12026-08-10T07:00:00+00:00299.4Advanced ScienceCurrent lung cancer screening fails to identify many individuals at risk beyond heavy smokers, highlighting the need for additional predictive biomarkers. This study profiles circulating exosomal small non-coding RNAs (sncRNAs) in a prospective cohort of 202 smokers, including 68 incident lung cancer cases with up to 16 years of follow-up. A structured 5×5 nested cross-validation framework incorporating feature selection, classifier comparison, and outer-loop evaluation identifies a panel of 31 sncRNA risk biomarkers. The optimized random forest model achieves an area under the curve (AUC) of 0.97 in outer-fold testing (sensitivity = 0.93; specificity = 1.00). The derived risk score remains independently associated with incident lung cancer after adjustment for demographic and smoking variables (odds ratio [OR] = 13.19, 95% confidence interval [CI] 6.83–25.45) and is associated with shorter time-to-diagnosis in competing risks analysis (subdistribution hazard ratio [sHR] = 4.78, 95% CI 3.57–6.41). Associations are observed up to 10 years prior to diagnosis. Target gene analysis implicates pathways relevant to lung tumorigenesis, including PI3K-Akt, p53, and MAPK signaling. These findings suggest that plasma exosomal sncRNAs may contribute to early lung cancer risk assessment and warrant further evaluation in independent pre-diagnostic cohorts.https://cassyni-user-files-prod.s3.amazonaws.com/Vd7z8icyewGT1j32YA6DqQ https://cassyni.com/events/9yKVgZ4ru2zyj8kLnLyVqX/seminar/qa https://cassyni.com/slides/outline/9yKVgZ4ru2zyj8kLnLyVqX https://cassyni.com/events/9yKVgZ4ru2zyj8kLnLyVqX/abstract https://cassyni-user-files-prod.s3.amazonaws.com/V8vdpxNdP4LnhLLRGmyeTg https://cassyni.com/events/9yKVgZ4ru2zyj8kLnLyVqX?videoPreview=1 Science based approaches for conservation prioritisation and target settingnohttps://cassyni.com/events/9yKVgZ4ru2zyj8kLnLyVqX?videoPreview=12024-04-25T10:00:00+00:002894.04Cambridge PrismsGlobally we are beginning to realise the need for policies built on evidence, and for environmental policy that entails science-based policy. Yet, any analysis is only as good as the data used to conduct it, thus understanding the limitations and assumptions in environmental data is crucial to ensuring it’s sensible and effective use. The digital revolution has seemingly changed the problem for many ecologists trying to understand the natural world from having insufficient data to approach many ecological questions, to one of how to usefully analyse ever growing volumes of data. Yet despite this huge volume of data, natural biases within the data require caution to ensure their sensible use, as those biases shape the outcomes of our analysis and may misrepresent true ecological patterns as a consequence. We also explore how different modes of data collection and the impact of citizen science in shaping our understanding of species patterns and how it may actually exacerbate rather than ameliorate existing biases. However guiding sensible use and providing more robust solutions is key, thus building from this we provide recommendations to help guide sensible and effective use and interpretation of data, frameworks to enable more effective use of data within its sensible limits, and better approaches for the generation of further data to aid the development of effective conservation, policy and management. We also demonstrate how data can be sensitively analysed and applied to help create better and more sensitive environmental targets, and can also help align, such as ecological conservation redline policy and to maximise the synergies between climate and biodiversity targets. https://cassyni-user-files-prod.s3.amazonaws.com/V8vdpxNdP4LnhLLRGmyeTg https://cassyni.com/events/LMSPiEvqN9JUsvzryqD1f3/seminar/qa https://cassyni.com/slides/outline/LMSPiEvqN9JUsvzryqD1f3 https://cassyni.com/events/LMSPiEvqN9JUsvzryqD1f3/abstract https://cassyni-user-files-prod.s3.amazonaws.com/7dojB51wHVutRxRiL597UA https://cassyni.com/events/LMSPiEvqN9JUsvzryqD1f3?videoPreview=1 Modern vs. classical structures of opposition: A discussionnohttps://cassyni.com/events/LMSPiEvqN9JUsvzryqD1f3?videoPreview=12024-04-10T14:00:00+00:004962.04Logica UniversalisThe aim of this work is to revisit the proposal made by Dag Westerståhl a decade ago when he provided a modern reading of the traditional square of opposition and of related structures. We propose a formalization of this modern view and contrast it with the classical one.We discuss what may be a modern hexagon of opposition and a modern cube, and show their interest in particular for relating quantitative expressions. https://cassyni-user-files-prod.s3.amazonaws.com/7dojB51wHVutRxRiL597UA https://cassyni.com/slides/outline/2Yx7MpWc3sPRq9XtYhex5s https://cassyni.com/events/2Yx7MpWc3sPRq9XtYhex5s/abstract https://cassyni-user-files-prod.s3.amazonaws.com/3bbVw8w546J2y4saJAzTxi https://cassyni.com/events/2Yx7MpWc3sPRq9XtYhex5s?videoPreview=1 We Are Plastic: The Tempestnohttps://cassyni.com/events/2Yx7MpWc3sPRq9XtYhex5s?videoPreview=12020-04-21T12:00:00+00:00158.08Hong Kong Baptist UniversityDr Jun Pan reads per poem, 'We Are Plastic: The Tempest', in "Mingled Voices 4: International Proverse Poetry Prize Anthology 2019" (Proverse Hong Kong, 2020, p. 119).https://cassyni-user-files-prod.s3.amazonaws.com/3bbVw8w546J2y4saJAzTxi https://cassyni.com/events/33biQWA8VKwUpv4n98wkMB/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Q1kmuZPf1VvSkngSN5XBiW https://cassyni.com/events/33biQWA8VKwUpv4n98wkMB?videoPreview=1 Christian Perspective on Desirenohttps://cassyni.com/events/33biQWA8VKwUpv4n98wkMB?videoPreview=12021-08-11T12:00:00+00:00354.0Hong Kong Baptist UniversityAbstract not yet added.https://cassyni-user-files-prod.s3.amazonaws.com/Q1kmuZPf1VvSkngSN5XBiW https://cassyni.com/slides/outline/9xgB45DUdjhGKj4MWaWgVs https://cassyni.com/events/9xgB45DUdjhGKj4MWaWgVs/abstract https://cassyni-user-files-prod.s3.amazonaws.com/sST98svt81gQ6WS2LKu58 https://cassyni.com/events/9xgB45DUdjhGKj4MWaWgVs?videoPreview=1 Harpsichord Recital: David Chungnohttps://cassyni.com/events/9xgB45DUdjhGKj4MWaWgVs?videoPreview=12025-02-14T12:00:00+00:002184.52Hong Kong Baptist UniversityNo abstracthttps://cassyni-user-files-prod.s3.amazonaws.com/sST98svt81gQ6WS2LKu58 https://cassyni.com/slides/outline/KqDvGJRgNUsgyn2Wmnb5wK https://cassyni.com/events/KqDvGJRgNUsgyn2Wmnb5wK/abstract https://cassyni-user-files-prod.s3.amazonaws.com/A4ig8Do8zT4ZU4S9tD5b1Q https://cassyni.com/events/KqDvGJRgNUsgyn2Wmnb5wK?videoPreview=1 Global Blackness and Black Left Scholarshipnohttps://cassyni.com/events/KqDvGJRgNUsgyn2Wmnb5wK?videoPreview=12025-05-08T12:00:00+00:009159.16Hong Kong Baptist UniversityNo abstracthttps://cassyni-user-files-prod.s3.amazonaws.com/A4ig8Do8zT4ZU4S9tD5b1Q https://cassyni.com/slides/outline/WCqcEf1hb6W7WHKentXycq https://cassyni.com/events/WCqcEf1hb6W7WHKentXycq/abstract https://cassyni-user-files-prod.s3.amazonaws.com/PdQGaXgYCDnoJ6kPxBJCG6 https://cassyni.com/events/WCqcEf1hb6W7WHKentXycq?videoPreview=1 Atheism in Hinduismnohttps://cassyni.com/events/WCqcEf1hb6W7WHKentXycq?videoPreview=12021-09-01T12:00:00+00:00409.52Hong Kong Baptist UniversityDo you know that Hinduism is very compatible with Atheism? Does Hindu Philosophy really not believe in a creator god?https://cassyni-user-files-prod.s3.amazonaws.com/PdQGaXgYCDnoJ6kPxBJCG6 https://cassyni.com/events/RGMZmpYTCWy67BcJnQpyth/abstract https://cassyni-user-files-prod.s3.amazonaws.com/8NBfvBhZ5C3f9zDTz7wJ2J https://cassyni.com/events/RGMZmpYTCWy67BcJnQpyth?videoPreview=1 Catholic and Protestant Discuss Catholicismnohttps://cassyni.com/events/RGMZmpYTCWy67BcJnQpyth?videoPreview=12023-09-30T12:00:00+00:004582.2Hong Kong Baptist UniversityAbstract not yet added.https://cassyni-user-files-prod.s3.amazonaws.com/8NBfvBhZ5C3f9zDTz7wJ2J https://cassyni.com/events/3Xpyjk5MtNbgJSL2QKSKCH/abstract https://cassyni-user-files-prod.s3.amazonaws.com/XpcE9PXVUWAPatHXaPZHJ6 https://cassyni.com/slides/outline/DRDQNrk9hwZuMRMvAEte2h https://cassyni.com/events/DRDQNrk9hwZuMRMvAEte2h/abstract https://cassyni-user-files-prod.s3.amazonaws.com/JFzSGk6dwAuQyvDqFzRRF4 https://cassyni.com/events/DRDQNrk9hwZuMRMvAEte2h?videoPreview=1 What is “post-apocalypse”? How should we treat it?nohttps://cassyni.com/events/DRDQNrk9hwZuMRMvAEte2h?videoPreview=12024-06-27T12:00:00+00:00494.48Hong Kong Baptist UniversityWhenever something big happens in the world, predictions of the apocalypse would arise, followed by a surge in creative content themed around the post-apocalypse. So, what exactly is meant by "post-apocalypse"? And why does this concept emerge?https://cassyni-user-files-prod.s3.amazonaws.com/JFzSGk6dwAuQyvDqFzRRF4 https://cassyni.com/slides/outline/CRvCHVT6q2TkgfXv4GRKDo https://cassyni.com/events/CRvCHVT6q2TkgfXv4GRKDo/abstract https://cassyni-user-files-prod.s3.amazonaws.com/AWxjLm8SnsxAajnMEW4SKY https://cassyni.com/events/CRvCHVT6q2TkgfXv4GRKDo?videoPreview=1 Material Culture and Design in Modern Asianohttps://cassyni.com/events/CRvCHVT6q2TkgfXv4GRKDo?videoPreview=12021-03-18T12:00:00+00:0012905.84Hong Kong Baptist UniversityThis symposium will explore the complexity of material culture and design in Asian cultures, focusing on four themes: the nature and experience of materiality, the social effect of material culture, aesthetics as a cultural expression, and the biography of a design. Speakers will examine examples from different cultures that reveal distinctive characteristics in Asian designs, including architecture, ceramics, decorative art, fashion, furniture, graphic, and interior design. Discussions will reveal intricate historical and social dynamics that are fundamental to design innovation and cultural revitalization.https://cassyni-user-files-prod.s3.amazonaws.com/AWxjLm8SnsxAajnMEW4SKY https://cassyni.com/slides/outline/LpX8MfijFPyqeXrWsm4QkD https://cassyni.com/events/LpX8MfijFPyqeXrWsm4QkD/abstract https://cassyni-user-files-prod.s3.amazonaws.com/VEfKTxL8psDHyvYbzNsUJz https://cassyni.com/events/LpX8MfijFPyqeXrWsm4QkD?videoPreview=1 Nationalism, Nation and Sacrifice in the Chinese Churchnohttps://cassyni.com/events/LpX8MfijFPyqeXrWsm4QkD?videoPreview=12023-11-10T12:00:00+00:005308.16Hong Kong Baptist UniversityWhat are we to make of Christian nationalism in China, and its biblical and theological justifications? This talk begins with understandings of “nation” in the early twentieth century as the dynastic empire was reinvented as a nation state, and Christian nationalism developed as both a constructive cause—building a new republic, creating a citizenship that could take charge of its own destiny—and a reaction to foreign imperialism. Using a series of articles from Tian Feng 天風 in 1950-53, the talk focuses on the new discourse on nation and Christian sacrifice that emerged among liberal Protestants in the early People’s Republic of China. Sacrifice was a central motif in Christian writings in this time of war, as believers were called on to sacrifice old ways and old ideas, as well as to make the ultimate sacrifice of their lives, in the name of the nation.https://cassyni-user-files-prod.s3.amazonaws.com/VEfKTxL8psDHyvYbzNsUJz https://cassyni.com/slides/outline/PHm9b5xMSgkL1UL5RSy3U9 https://cassyni.com/events/PHm9b5xMSgkL1UL5RSy3U9/abstract https://cassyni-user-files-prod.s3.amazonaws.com/T7eUWPvUBxgRRzCZ4hmXH8 https://cassyni.com/events/PHm9b5xMSgkL1UL5RSy3U9?videoPreview=1 Disobedient Imageries: Netizens and their Critical-political Practices in Hong Kongnohttps://cassyni.com/events/PHm9b5xMSgkL1UL5RSy3U9?videoPreview=12024-05-13T12:00:00+00:001045.56Hong Kong Baptist UniversityThe paper provides an overview of the making of disobedient imageries related to grassroots social movements in Hong Kong in the past decade. Through establishing the notion of ‘disobedient imageries,’ illustrating the notion by examples of digital artefacts that was once active in the virtual domain, and through contextualising the complexity and complication of civil disobedience and image-making in the Hong Kong milieu, the paper articulates and addresses how grassroots social movements sustain ephemeral and contingent virtual communities of image-making from an East-Asian experience. The paper argues that virtual communities in image-making are exponentially flourished and networked, however these communities are also situated and conditioned by the lived experiences, for example image and political censorships in authoritarian regime; whereas connecting virtual communities across spatial-temporal dimensions will reflect on a critical practice in researching these communities. The paper will summarise strategies and tactics in preserving and curating the critical-political practices.https://cassyni-user-files-prod.s3.amazonaws.com/T7eUWPvUBxgRRzCZ4hmXH8 https://cassyni.com/slides/outline/614zyAJz5fNDLbZos7EgCV https://cassyni.com/events/614zyAJz5fNDLbZos7EgCV/abstract https://cassyni-user-files-prod.s3.amazonaws.com/BG6QPgMY49edMGKhLh12vS https://cassyni.com/events/614zyAJz5fNDLbZos7EgCV?videoPreview=1 Building a community of practice in research informed teaching & learningnohttps://cassyni.com/events/614zyAJz5fNDLbZos7EgCV?videoPreview=12025-11-21T12:00:00+00:00160.56Hong Kong Baptist UniversityThis seminar explores the development of a community of practice aimed at integrating research-informed approaches into teaching and learning. The community facilitated collaborative inquiry through joint planning, iterative testing with students, and reflective refinement of pedagogical strategies. Key insights include the adaptation of industry focus group techniques into rigorous classroom research, enhancing students’ ability to gather and justify evidence. Structured project design, characterized by thematic coherence, student-selected subtopics, and staged checkpoints from literature review to findings, was shown to promote ownership and improve learning outcomes. Emphasizing student-centered topics was found to deepen engagement and enrich data quality by connecting academic tasks to students’ lived experiences, thereby fostering skills and empathy beyond grading metrics. The integration of artificial intelligence (AI) tools, as demonstrated in social listening projects and fact-checking exercises, broadened student perspectives while underscoring the necessity of critical evaluation and data verification. Contributions from library specialists and faculty highlighted effective data sourcing and search strategies, reinforcing the importance of scaffolding complex projects and embedding authentic stakeholders. The community’s collaborative framework yielded practical designs, accessible data resources, and a sustainable momentum for advancing research-informed teaching practices within academic symposia, courses, and broader educational communities.https://cassyni-user-files-prod.s3.amazonaws.com/BG6QPgMY49edMGKhLh12vS https://cassyni.com/slides/outline/8UK2CaYcGx8hhY3NQo9JvR https://cassyni.com/events/8UK2CaYcGx8hhY3NQo9JvR/abstract https://cassyni-user-files-prod.s3.amazonaws.com/yFsQFFCy4FUTHwx1KoxNJ https://cassyni.com/events/8UK2CaYcGx8hhY3NQo9JvR?videoPreview=1 The Singapore Story and Brand in a Post-Pandemic Worldnohttps://cassyni.com/events/8UK2CaYcGx8hhY3NQo9JvR?videoPreview=12021-07-20T12:00:00+00:003848.12Hong Kong Baptist UniversitySingapore is a small and geopolitically vulnerable country with a post-colonial multicultural society and limited natural resources. It is led by an authoritarian, meritocratic, and pragmatic government that has enabled the nation to achieve remarkable success over a short period of time. These are the key elements of Singapore's national narrative and brand, and, in turn, the basis of its international soft power. Drawing upon themes from his book "Singapore: Identity, Brand, Power", Professor Kenneth Paul Tan of the Hong Kong Baptist University will discuss emerging trends that may re-shape and transform the Singapore narrative and brand in a post-pandemic world.https://cassyni-user-files-prod.s3.amazonaws.com/yFsQFFCy4FUTHwx1KoxNJ https://cassyni.com/slides/outline/14axWKqjh5qBwVrTrdXgUM https://cassyni.com/events/14axWKqjh5qBwVrTrdXgUM/abstract https://cassyni-user-files-prod.s3.amazonaws.com/79HrGqynSvkG8gctUtTPmp https://cassyni.com/events/14axWKqjh5qBwVrTrdXgUM?videoPreview=1 The Christian Contributions to Medicine in Hong Kong during WWIInohttps://cassyni.com/events/14axWKqjh5qBwVrTrdXgUM?videoPreview=12021-11-04T12:00:00+00:003535.48Hong Kong Baptist UniversityThis seminar examines the Christian contributions to medicine in Hong Kong during World War II through the career of Dr. Gordon King, a medical missionary and professor whose work bridged China and Hong Kong amid geopolitical upheavals. Situated within the broader context of early 20th-century Sino-foreign Protestant missionary activity, the analysis highlights the dual role of missionary medicine in advancing biomedicine and medical education in China, despite nationalist and anti-Christian movements. Dr. King’s trajectory—from teaching gynecology at Peking Union Medical College and Cheeloo University to leading medical education in Hong Kong—was shaped by Japanese military aggression and wartime displacements. His commitment to uninterrupted medical training for Hong Kong University students during Japanese occupation involved securing financial support, arranging placements in multiple Chinese medical colleges (three of which were Christian institutions), and advocating for recognition by the British Medical Council and Hong Kong government. The study underscores the implicit Christian character of King’s later work, contrasting with his earlier explicit missionary identity, and situates his efforts within a network of Sino-Christian medical institutions. Reflections from contemporaneous students emphasize King’s leadership and the continuity of medical services postwar. The seminar also addresses the complex interplay between Christian medical professionalism, colonial society, and wartime exigencies, illustrating how missionary legacies influenced Hong Kong’s medical development and highlighting the nuanced expressions of faith in professional contexts.https://cassyni-user-files-prod.s3.amazonaws.com/79HrGqynSvkG8gctUtTPmp https://cassyni.com/events/6Ws8hf5r2uu73b68ndmySu/seminar/qa https://cassyni.com/slides/outline/6Ws8hf5r2uu73b68ndmySu https://cassyni.com/events/6Ws8hf5r2uu73b68ndmySu/abstract https://cassyni-user-files-prod.s3.amazonaws.com/CUSYEUytoZR4JNsHrK3VRp https://cassyni.com/events/6Ws8hf5r2uu73b68ndmySu?videoPreview=1 High-Order Incompressible Computational Fluid Dynamics on Modern Hardware Architecturesnohttps://cassyni.com/events/6Ws8hf5r2uu73b68ndmySu?videoPreview=12021-06-17T14:00:00+00:003096.64PyFRModern GPU architectures are characterised by an abundance of compute capability relative to memory bandwidth. This makes them very well-suited to solving temporally explicit and spatially compact discretisations of hyperbolic conservation laws. However, classical pressure-projection-based incompressible Navier–Stokes formulations do not fall into this category. One attractive formulation for solving incompressible problems on modern hardware is the method of artificial compressibility. When combined with explicit dual time stepping and a high-order Flux Reconstruction discretisation, the majority of operations can be cast as arithmetically intensive matrix–matrix multiplications that are well-suited for GPUs. In this seminar, I will present the high-order cross-platform incompressible Navier–Stokes solver in PyFR, together with three explicit convergence acceleration techniques: a polynomial multigrid, a novel locally adaptive pseudo-time stepping approach and novel stability-optimised Runge-Kutta schemes. The solver and the convergence acceleration techniques are validated for a range of turbulent test cases, including a simulation of the DARPA SUBOFF submarine model using hundreds of NVIDIA GPUs.https://cassyni-user-files-prod.s3.amazonaws.com/CUSYEUytoZR4JNsHrK3VRp https://cassyni.com/slides/outline/KrUwQdcZViZPbzdBHtJxPo https://cassyni.com/events/KrUwQdcZViZPbzdBHtJxPo/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Hsqb2HsXJhZU7iboMEwQAS https://cassyni.com/events/KrUwQdcZViZPbzdBHtJxPo?videoPreview=1 Longitudinal electromagnetic waves with extremely short wavelengthnohttps://cassyni.com/events/KrUwQdcZViZPbzdBHtJxPo?videoPreview=12021-05-18T14:00:00+00:003780.36MetaMATElastic waves may have either longitudinal or transverse polarization: the acoustic (compression) waves are longitudinal while the sheer stress waves are usually transverse. The electromagnetic waves are in many aspects similar to the elastic ones. However, the electromagnetic waves in vacuum and most materials have transverse polarization. Longitudinal electromagnetic waves with electric field parallel to wave vector are very rare and appear under special conditions in a limited class of media, for example in plasma. In this work, we study the dispersion properties of an easy-to-manufacture metamaterial consisting of two three-dimensional cubic lattices of connected metallic wires inserted one into another, also known as an interlaced wire medium. It is shown that the metamaterial supports longitudinal waves at extremely wide frequency band from very low frequencies up to the Bragg resonances of the structure. The waves feature unprecedentedly short wavelengths comparable to the period of the material. The revealed effects highlight spatially dispersive response of interlaced wire medium and provide a route toward generating electromagnetic fields with strong spatial variation.https://cassyni-user-files-prod.s3.amazonaws.com/Hsqb2HsXJhZU7iboMEwQAS https://cassyni.com/slides/outline/WE6dNzCaiLBp8VvKJzFr5K https://cassyni.com/events/WE6dNzCaiLBp8VvKJzFr5K/abstract https://cassyni-user-files-prod.s3.amazonaws.com/LUF1Wt22cMTytuQ92K9AXG https://cassyni.com/events/WE6dNzCaiLBp8VvKJzFr5K?videoPreview=1 Wave Control for Wireless Communications: From Time-Reversal to Reconfigurable Intelligent Metasurfacesnohttps://cassyni.com/events/WE6dNzCaiLBp8VvKJzFr5K?videoPreview=12020-12-15T14:00:00+00:005259.12MetaMATIn this talk, I will show how the works performed at Langevin Institute have led 8 years ago to the seminal concept behind large reconfigurable intelligent surfaces (RIS) that is currently a topic of great interest in the wireless communication community and that is proposed as a new paradigm for the sixth generation (6G) of communication networks. Starting with the first demonstrations of ultrasonic time-reversal focusing in complex media, I will underline how these ideas were transposed later, for electromagnetic waves, into the concept of massive multi-user multiple-input multiple-output (MIMO) for the 5G communication networks. Then, I will explain how, working on the concept of wavefront shaping using spatial light modulators in optics, we propose an equivalent for the microwave domain, using tunable metasurfaces, a concept that would solve the drastic price problem of active techniques like time reversal MIMO. By smartly tuning the signal reflection of large metasurfaces, reconfigurable tunable metasurfaces are capable of dynamically altering wireless channels in disordered environments to enhance the communication performance. Using reconfigurable metasurfaces placed inside any complex environment, we tune the medium complexity to obtain the best communication performance. Compared to the well-known massive multiple-input multiple-output (MIMO) technique, RIS can provide excellent system performance without requiring power-hungry components such as power amplifiers.https://cassyni-user-files-prod.s3.amazonaws.com/LUF1Wt22cMTytuQ92K9AXG https://cassyni.com/slides/outline/WikERfr79njs8GTCuRYeLd https://cassyni.com/events/WikERfr79njs8GTCuRYeLd/abstract https://cassyni-user-files-prod.s3.amazonaws.com/FXg6iA181hA9TuWVG4oBE6 https://cassyni.com/events/WikERfr79njs8GTCuRYeLd?videoPreview=1 Bio-inspired hierarchical metamaterialsnohttps://cassyni.com/events/WikERfr79njs8GTCuRYeLd?videoPreview=12020-06-16T14:00:00+00:006353.68MetaMATNature has engineered complex designs to achieve advanced properties and functionalities over hundreds of thousands of years. For instance, a hierarchical organization over multiple length scales allows enhanced quasistatic mechanical properties (such as high specific strength, stiffness, and toughness). While largely investigated in the quasistatic domain, the role of hierarchy in the dynamic behaviour of metamaterials remains largely unexplored. In this webinar a numerical and experimental investigation of the influence of bio-inspired hierarchical organization on the wave dispersion diagram in metamaterials with self-similar structures at various spatial scales is presented. The advantages (and limitations) that the hierarchical architectures provide for the dynamic performance with respect to conventional metamaterials will be discussed.https://cassyni-user-files-prod.s3.amazonaws.com/FXg6iA181hA9TuWVG4oBE6 https://cassyni.com/events/aP6EpcbeLN5eVNnnA4yim/abstract https://cassyni-user-files-prod.s3.amazonaws.com/A4AWP9vc1Zr5fSFqcscdmY https://cassyni.com/slides/outline/34Qmim6qAnoZ7BwB8K3DUZ https://cassyni.com/events/34Qmim6qAnoZ7BwB8K3DUZ/abstract https://cassyni-user-files-prod.s3.amazonaws.com/52jzheaavbMcETNnTeBLAA https://cassyni.com/events/34Qmim6qAnoZ7BwB8K3DUZ?videoPreview=1 A History of /s/-retraction in New Zealand Englishnohttps://cassyni.com/events/34Qmim6qAnoZ7BwB8K3DUZ?videoPreview=12020-12-04T16:00:00+00:003287.36Linguistics and Applied Language Studies/s/-retraction refers to a sound change whereby /s/ becomes more /esch/-like in certain phonetic contexts, most notably /str/ clusters (e.g. ‘Aushtralia’). In this talk, we make use of Reuben's recent Master's project to show how this sound change has developed over time in NZE. Using data drawn from the Origins of New Zealand English corpus we consider the linguistic and social factors that have influenced its spread through NZE. https://cassyni-user-files-prod.s3.amazonaws.com/52jzheaavbMcETNnTeBLAA https://cassyni.com/slides/outline/RnBKcwqCZ8RkdsbFucCT41 https://cassyni.com/events/RnBKcwqCZ8RkdsbFucCT41/abstract https://cassyni-user-files-prod.s3.amazonaws.com/3684MVgvTrtnSdQ9wBZvZC https://cassyni.com/slides/outline/awYXQvKhYtcaLtfTMT9aM https://cassyni.com/events/awYXQvKhYtcaLtfTMT9aM/abstract https://cassyni-user-files-prod.s3.amazonaws.com/HTCB9PD2yDNQ5VEmAC3fYa https://cassyni.com/events/awYXQvKhYtcaLtfTMT9aM?videoPreview=1 Sweating the small stuff: exploring the microclimate ecology of grassland birdsnohttps://cassyni.com/events/awYXQvKhYtcaLtfTMT9aM?videoPreview=12025-01-03T12:00:00+00:001705.0Royal Society PublishingIn this seminar, I discuss the concepts of microclimate buffering and micro-refugia as they relate to the nesting ecology of a declining grassland songbird bird community in North America's Tallgrass prairie region. Microclimates occur near the ground-surface where climate conditions vary at fine scales with heterogeneity in environmental features such as vegetation and microtopography. Microclimate conditions may impact the ecology of species in many ways, particularly if they interact with habitat at very fine resolutions. Buffering from or greater exposure to climate extremes associated with the habitat species select may inform their climate vulnerability. Grassland songbirds are the most rapidly declining avian group in North America and existing research suggests that their demographics are highly sensitive to temperature extremes and drought. Additionally, though they inhabit the same broad grassland ecosystems, grassland birds have specific microhabitat requirements that often fall along a continuum of preferences for short and sparse cover to denser and taller vegetation, sometime including shrubs. In particular, grassland obligates (e.g. specialists) are generally true-ground nesters and use relatively short grass cover. By contrast, facultative (e.g., more generalist) species often display flexibility to use denser vegetation clumps and shrubs. Here, we explored how grassland birds selected for microclimate conditions, the demographic consequences of microclimatic exposure for nesting success, and how obligate and facultative groups may differ in vulnerability to climate due to differences in their habitat associations. https://cassyni-user-files-prod.s3.amazonaws.com/HTCB9PD2yDNQ5VEmAC3fYa https://cassyni.com/slides/outline/UFRLrN4pkRCEzp4pTJ75mw https://cassyni.com/events/UFRLrN4pkRCEzp4pTJ75mw/abstract https://cassyni-user-files-prod.s3.amazonaws.com/KWLsTmHFQjiWJ3vsVk8tEz https://cassyni.com/events/UFRLrN4pkRCEzp4pTJ75mw?videoPreview=1 Computer Algebra in Physics: The hidden SO(4) symmetry of the hydrogen atomnohttps://cassyni.com/events/UFRLrN4pkRCEzp4pTJ75mw?videoPreview=12021-10-19T15:00:00+00:003536.04Computer Physics CommunicationsPauli first noticed the hidden SO(4) symmetry for the hydrogen atom in the early stages of quantum mechanics [1]. Starting from that symmetry, one can recover the spectrum of a spinless hydrogen atom and the degeneracy of its states without explicitly solving Schrödinger's equation [2], [3]. In this paper, we derive that SO(4) symmetry and spectrum using a computer algebra system (CAS). While this problem is well known [4], [5], its solution involves several steps of manipulating expressions with tensorial quantum operators, including simplifying them by taking into account a combination of commutator rules and Einstein's sum rule for repeated indices. Therefore, it is an excellent model to test the current status of CAS concerning this kind of quantum-and-tensor-algebra computations and to showcase the CAS technique. Generally speaking, when capable, CAS can significantly help with manipulations that, like non-commutative tensor calculus subject to algebra rules, are tedious, time-consuming and error-prone. The presentation also shows two alternative patterns of computer algebra steps that can be used for systematically tackling more complicated symbolic problems of this kind. https://cassyni-user-files-prod.s3.amazonaws.com/KWLsTmHFQjiWJ3vsVk8tEz https://cassyni.com/slides/outline/FQbFmDm4jsieAs8WwAASUd https://cassyni.com/events/FQbFmDm4jsieAs8WwAASUd/abstract https://cassyni-user-files-prod.s3.amazonaws.com/BQwvG2xJDaNJaw4B6zyMV8 https://cassyni.com/events/FQbFmDm4jsieAs8WwAASUd?videoPreview=1 Monitoring gas narcosis in hyperbaric environmentsnohttps://cassyni.com/events/FQbFmDm4jsieAs8WwAASUd?videoPreview=12021-08-10T04:00:00+00:002921.0The Auckland Bioengineering InstituteNo abstracthttps://cassyni-user-files-prod.s3.amazonaws.com/BQwvG2xJDaNJaw4B6zyMV8 https://cassyni.com/slides/outline/7ztpBba5ZNLaWHeX8nkDCh https://cassyni.com/events/7ztpBba5ZNLaWHeX8nkDCh/abstract https://cassyni-user-files-prod.s3.amazonaws.com/6BWbUFzQv9ShgoJKadoJEz https://cassyni.com/events/7ztpBba5ZNLaWHeX8nkDCh?videoPreview=1 PDE problems in the Landau-de Gennes theory for Nematic Liquid Crystalsnohttps://cassyni.com/events/7ztpBba5ZNLaWHeX8nkDCh?videoPreview=12021-06-17T15:00:00+00:002877.52Partial Differential Equations and ApplicationsNematic liquid crystals are classical examples of partially ordered materials that combine fluidity with the order of crystalline solids. Nematics have long-range orientational order i.e. they are directional materials with special directions, referred to as directors. The Landau-de Gennes theory is one of the most celebrated and powerful continuum theories for nematic liquid crystals. In this talk, we review the mathematical framework for the Landau-de Gennes theory with emphasis on the Landau-de Gennes free energy and the associated Euler-Lagrange equations, which are typically a system of coupled, nonlinear partial differential equations. We review some recent results for boundary-value problems in the Landau-de Gennes theory, including results on the multiplicity, defect sets and asymptotic analysis of energy-minimizing solutions. We also describe the physical relevance of these solutions, followed by case studies of applications in the physical sciences and industry.https://cassyni-user-files-prod.s3.amazonaws.com/6BWbUFzQv9ShgoJKadoJEz https://cassyni.com/slides/outline/8zFGWDtuF1JYsky78iEFX3 https://cassyni.com/events/8zFGWDtuF1JYsky78iEFX3/abstract https://cassyni-user-files-prod.s3.amazonaws.com/WQzAyWgahe5gAVAAdcy4cN https://cassyni.com/events/8zFGWDtuF1JYsky78iEFX3?videoPreview=1 Visual grammar of NZSLnohttps://cassyni.com/events/8zFGWDtuF1JYsky78iEFX3?videoPreview=12022-05-24T02:00:00+00:001011.76Deaf Studies Research UnitHow does NZSL use 3D space and movement to optimise grammar for visual communication? Rachel McKee discusses some aspects of how sign language structure differs from spoken language, and answers some frequently asked questions about sign languages.https://cassyni-user-files-prod.s3.amazonaws.com/WQzAyWgahe5gAVAAdcy4cN https://cassyni.com/slides/outline/aXCoyC2f8ziPBSeAqNX73 https://cassyni.com/events/aXCoyC2f8ziPBSeAqNX73/abstract https://cassyni-user-files-prod.s3.amazonaws.com/EroxKi3TvrZWh1nSBK1Fc https://cassyni.com/events/aXCoyC2f8ziPBSeAqNX73?videoPreview=1 Metallic or Dielectric Metasurfaces? Which one is better?nohttps://cassyni.com/events/aXCoyC2f8ziPBSeAqNX73?videoPreview=12022-06-21T13:00:00+00:004583.76MetaMATMetasurfaces are an array of periodic subwavelength nanostructures that resonantly couple to the incident light. Such nanostructured surfaces can reproduce the functions of bulk optics, and on occasions, offer new functionalities that are not possible with conventional diffractive optics. Metallic metasurfaces, employing resonant oscillation of surface-plasmons, can confine light in the nanoscale gaps, so-called hot spots, with extreme sensitivity to the refractive index of the environment. However, the price of such characteristics is the high ohmic losses of metallic nanoparticles. On the other hand, high-index dielectric and semiconductor metasurfaces are lossless. They can stimulate Mie resonances in a multipolar fashion, applicable to both linear and nonlinear regimes, although they produce much weaker hot spots. The benefits of metallic or dielectric metasurfaces have been a subject of debate in the last decade. In this seminar, I review my journey in employing metallic to dielectric and semiconductor metasurfaces in both linear and nonlinear regimes. I will discuss the benefits of each of them for certain applications ranging from ultra-sensitive detection to near-infrared imaging. https://cassyni-user-files-prod.s3.amazonaws.com/EroxKi3TvrZWh1nSBK1Fc https://cassyni.com/slides/outline/9yVENLABKCZLbzvkVkc9dF https://cassyni.com/events/9yVENLABKCZLbzvkVkc9dF/abstract https://cassyni-user-files-prod.s3.amazonaws.com/7R8c5y7E1npuC3mswNrtKg https://cassyni.com/events/9yVENLABKCZLbzvkVkc9dF?videoPreview=1 On total variation flow type equationsnohttps://cassyni.com/events/9yVENLABKCZLbzvkVkc9dF?videoPreview=12020-10-19T15:00:00+00:003498.68Partial Differential Equations and ApplicationsThe classical total variation flow is the $L^2$ gradient flow of the total variation. The total variation of a function u is one-Dirichlet energy, i.e.,$ \int |Du| dx$. Different from the Dirichlet energy $\int |Du|^2 dx/2$, the energy density is singular at the place where the slope of the function u equals zero. Because of this structure, its gradient flow is actually non-local in the sense that the speed of slope zero part (called a facet) is not determined by infinitesimal quantity. Thus, the definition of a solution itself is a nontrivial issue even for the classical total variation flow. This becomes more serious if there is non-uniform driving force term. Recently, there need to study various types of such equations.A list of examples includes the total variation map flow as well as the classical total variation flow and its fourth order version in image de - noising, crystalline mean curvature flow or fourth order total variation flow in crystal growth problems which are important models in materials science below roughening temperature. In this talk, we survey recent progress on these equations with special emphasis on a crystalline mean curvature flow whose solvability was left open more than ten years.We shall give a global - in -time unique solvability in the level - set sense.It includes a recent extension when there is spatially non - uniform driving force term which is going to be published in the journal SN Partial Differential Equations.These last well - posedness results are based on my joint work with N.Požár(Kanazawa University) whose basic idea depends on my earlier joint work with M. - H.Giga(The University of Tokyo) and N.Požár.https://cassyni-user-files-prod.s3.amazonaws.com/7R8c5y7E1npuC3mswNrtKg https://cassyni.com/slides/outline/RHcav9jLKkenjQCyJWYrMB https://cassyni.com/events/RHcav9jLKkenjQCyJWYrMB/abstract https://cassyni-user-files-prod.s3.amazonaws.com/AP686FYBMcaYWQmPKybsPC https://cassyni.com/events/RHcav9jLKkenjQCyJWYrMB?videoPreview=1 Transitions to condensate formation in two-dimensional turbulence and thin rotating fluid layersnohttps://cassyni.com/events/RHcav9jLKkenjQCyJWYrMB?videoPreview=12020-12-16T14:00:00+00:003089.88Department of AeronauticsTwo-dimensional (2d) and quasi-2d flows occur at macro- and mesoscale in a variety of physical systems. Examples include stratified layers in Earth's atmosphere and the ocean, soap films and more recently also in dense bacterial suspensions, where the collective motion of microswimmers induces patterns of mesoscale vortices. A characteristic feature of turbulence in 2d and thin fluid layers is the occurrence of an inverse energy cascade. In case of weak Rayleigh damping the inverse energy cascade results in the formation of large-scale coherent structures, so-called condensates, which can take the form of jets or large-scale vortices. With a view towards atmospheric physics, we study the formation of the condensate in a rotating thin fluid layer with free-slip boundary conditions as function of the amplitude of the forcing, and we compare with results obtained in strictly 2d domains. Direct numerical simulations show that the condensate in the thin rotating layer appears in a first-order non-equilibrium phase transition, with rare transitions occurring towards and away from the condensate state. In contrast, condensate formation 2d can proceed by means of either a first or a second-order non-equilibrium phase transition, depending on the type of driving.https://cassyni-user-files-prod.s3.amazonaws.com/AP686FYBMcaYWQmPKybsPC https://cassyni.com/slides/outline/FuJ73ASMz48EpLAVtmiunu https://cassyni.com/events/FuJ73ASMz48EpLAVtmiunu/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Azu8Q76auSGcvRd43oBoHQ https://cassyni.com/events/FuJ73ASMz48EpLAVtmiunu?videoPreview=1 Emission Spectroscopy Measurements in High Enthalpy Flowsnohttps://cassyni.com/events/FuJ73ASMz48EpLAVtmiunu?videoPreview=12021-12-15T16:00:00+00:002850.08Department of AeronauticsDuring spacecraft entry into planetary atmospheres, the gas around the space capsule is strongly compressed as the large kinetic energy of the hypervelocity flow is transferred into internal energy. This leads to very high surface heat transfer to the vehicle which is compensated by a heat shield. To date, these thermal protection systems are oversized due to the uncertainty we encounter in predicting the flowfield. One way to improve our understanding is to conduct ground-based experiments in wind tunnels which simulate the real high enthalpy flow of a flight case. A major challenge in using these experiments to improve our understanding are the complex measurement techniques and the interpretation of the data gathered through them. Many traditional aerodynamic measurement techniques are difficult to employ due to the extreme high temperature and high pressure environment. Emission spectroscopy uses the natural radiation from these flows to investigate the thermodynamic flow state. The technique separates the light emitted from the flow into its spectral components. The resulting spectra are collected and used to infer thermodynamic parameters without the need for intrusive measurement devices. Through the use of statistical thermodynamic theory, temperatures and particle densities can be inferred from an in-depth analysis of these spectra by assessing the population density of exited quantum states of atoms and molecules.https://cassyni-user-files-prod.s3.amazonaws.com/Azu8Q76auSGcvRd43oBoHQ https://cassyni.com/slides/outline/Axp4aKy7bUbDRET9tJ1v4m https://cassyni.com/events/Axp4aKy7bUbDRET9tJ1v4m/abstract https://cassyni-user-files-prod.s3.amazonaws.com/XmFnc3QXa4pVGXg1WHpNjp https://cassyni.com/events/Axp4aKy7bUbDRET9tJ1v4m?videoPreview=1 Understanding forest dynamics by integrating age and environmental changenohttps://cassyni.com/events/Axp4aKy7bUbDRET9tJ1v4m?videoPreview=12021-12-09T16:30:00+00:002103.84New PhytologistHow much carbon a forest ecosystem can sequester is determined by both postdisturbance regrowth and environmentally modified growth. Disturbance causes sharp declines in the short term and is followed by regrowth in the long term. Environmental change may alter carbon accumulation through increasing CO2, nitrogen deposition and climate change. Regrowth and modified growth occur simultaneously, yet they are usually studied separately and assessed using an additive approach. Alternatively, an interactive approach using hierarchical models can address their concurrent nature and evaluate their joint effects. Hierarchical models are informed by forest age data, which have recently become available at global scales. The age-based hierarchical framework provides a coherent and feasible way to integrate regrowth and modified growth in understanding forest dynamics.https://cassyni-user-files-prod.s3.amazonaws.com/XmFnc3QXa4pVGXg1WHpNjp https://cassyni.com/slides/outline/71erKVJoVB5nn3gsmkNK6V https://cassyni.com/events/71erKVJoVB5nn3gsmkNK6V/abstract https://cassyni-user-files-prod.s3.amazonaws.com/6kaZqmcMhfN6fhruK3pen2 https://cassyni.com/events/71erKVJoVB5nn3gsmkNK6V?videoPreview=1 Maps of phenomena for breaking waves in deep, intermediate, and shallow watersnohttps://cassyni.com/events/71erKVJoVB5nn3gsmkNK6V?videoPreview=12022-04-12T10:40:00+00:002225.04Water WavesNumerous numerical simulations were performed to investigate the phenomena occurring when waves break [1]. The Notus CFD code was used to solve the Navier-Stokes equations in the finite volume framework. The breaking event was inspected on a 2D periodic first order stokes waves over a flat bottom at different depths : shallow, intermediate and deep. The wavelength of the initial wave is varying from 5 cm to 35 cm. The observation of the breaking type (Parasitic Capillary Waves, Spilling Breaker and Plunging Breaker) of each simulation has permitted to generate three mapping of the phenomena occurring during the breaking process following the wavelength and the wave steepness. Firstly, we aim at presenting and discussing the mapping generated for the three different water depths. Then, an investigation of the vorticities created during the first steps of the breaking event will be presented. This investigation has permitted to observe three sub-categories, which has not been described in the literature, to the best of our knowledge : the spilling breaker with single vortex, with dipoles and the plunging breaker without roller. The characteristics of these sub-categories will be presented and explained thanks to the surface motion and the vorticities generated. The figure 1 is a representation of the vorticity field obtained during the spilling breaker with dipoles. Acknowledgements: This study has been carried out with financial support from the French State, managed by the French National Research Agency (ANR) in the frame of the ”Investments for the future” Programme IdEx Bordeaux - SysNum (ANR-10-IDEX-03-02).https://cassyni-user-files-prod.s3.amazonaws.com/6kaZqmcMhfN6fhruK3pen2 https://cassyni.com/slides/outline/GPyLCUbmpsc4doA1gsqsy7 https://cassyni.com/events/GPyLCUbmpsc4doA1gsqsy7/abstract https://cassyni-user-files-prod.s3.amazonaws.com/3BVhpDS9VFBesfCYJGThcr https://cassyni.com/events/GPyLCUbmpsc4doA1gsqsy7?videoPreview=1 A Bunch of Diagrammatic Methods for Syllogisticnohttps://cassyni.com/events/GPyLCUbmpsc4doA1gsqsy7?videoPreview=12021-05-19T10:40:00+00:005890.24Logica UniversalisThis paper presents, assesses, and compares six diagrammatic methods for Categorical Syllogistic. Venn’s Method is widely used in logic textbooks; Carroll’s Method is a topologically indistinguishable version of Venn’s Method; and the four remaining methods are my own: the Dual of Carroll’s Method, Gardner’s Method, Gardner–Peirce’s Method, and Ladd’s Method. These methods are divided into two groups of three and the reasons for switching from a method to another within each group are discussed. Finally, a comparison between the Dual of Carroll’s Method and Ladd’s Method supports the main result of the paper, which is an approximation of the two groups of methods.https://cassyni-user-files-prod.s3.amazonaws.com/3BVhpDS9VFBesfCYJGThcr https://cassyni.com/slides/outline/Poj21MpXp6qdGrNswKe41j https://cassyni.com/events/Poj21MpXp6qdGrNswKe41j/abstract https://cassyni-user-files-prod.s3.amazonaws.com/3vYyj8T6MWnypoRJ9A1KFU https://cassyni.com/events/Poj21MpXp6qdGrNswKe41j?videoPreview=1 On Nonmonotonic Consequence Relationsnohttps://cassyni.com/events/Poj21MpXp6qdGrNswKe41j?videoPreview=12022-05-11T13:00:00+00:007390.6Logica UniversalisWe discuss nonmonotonic reasoning in terms of consequence relations and corresponding operators. Based on the matrix consequence that gives the monotonic case, we define a restricted matrix consequence that illustrates the nonmonotonic case. The latter is a generalization of the relation of logical friendliness introduced by D. Makinson. We prove that any restricted single matrix consequence, although it may be nonmonotonic, is always weakly monotonic and, in the case of a finite matrix, the restricted matrix consequence is very strongly finitary. Further, by modifying the definition of logical friendliness relation formulated specifically in a proof-theoretic manner, we show a possibility of obtaining other reflexive nonmonotonic consequence relations, for which a limited result towards finitariness is proved. This leads to numerous questions about nonmonotonic consequence relations in the segment between the monotonic consequence relation based on intuitionistic propositional logic and logical friendliness.https://cassyni-user-files-prod.s3.amazonaws.com/3vYyj8T6MWnypoRJ9A1KFU https://cassyni.com/slides/outline/RnKSC6QdZw4PNZf7JHVzSH https://cassyni.com/events/RnKSC6QdZw4PNZf7JHVzSH/abstract https://cassyni-user-files-prod.s3.amazonaws.com/5k2LyPrELz4uwizvLxmqXc https://cassyni.com/events/RnKSC6QdZw4PNZf7JHVzSH?videoPreview=1 A branch-and-cut-and-price algorithm for the electric vechile routing problem with multiple technologiesnohttps://cassyni.com/events/RnKSC6QdZw4PNZf7JHVzSH?videoPreview=12021-02-11T15:51:37+00:00626.04Operations Research ForumNo abstracthttps://cassyni-user-files-prod.s3.amazonaws.com/5k2LyPrELz4uwizvLxmqXc https://cassyni.com/slides/outline/JsEyYXMHRXJbskfXvqw4Hb https://cassyni.com/events/JsEyYXMHRXJbskfXvqw4Hb/abstract https://cassyni-user-files-prod.s3.amazonaws.com/7rE8FNbPexExQmywvwFUMU https://cassyni.com/events/JsEyYXMHRXJbskfXvqw4Hb?videoPreview=1 Numerical modelling of phase-changing flows: sharp and diffuse-interface approachesnohttps://cassyni.com/events/JsEyYXMHRXJbskfXvqw4Hb?videoPreview=12022-08-08T12:00:00+00:003614.88Department of Chemical EngineeringFlows with phase change are of utmost importance in several industrial processes and natural phenomena. In a field where experiments are particularly demanding, high-fidelity numerical simulations may significantly contribute to capturing how the small-scale interfacial processes interact with the large-scale flow and the global heat- and mass-transport. In this seminar, we will therefore introduce two numerical approaches recently developed to fully-resolve phase changes flows. We will first consider sharp-interface approaches, where jump conditions are imposed at the moving interface. These are most suited for simulations in turbulent flows and have been used to consider droplet evaporation in canonical turbulent flows, see figure. Phase change is also the most efficient way to increase heat transfer since latent heat is typically much larger than sensible heat. Focusing on the case of boiling, recent advances in micro- and nano-fabrication techniques have shown how surface textures and chemistry can largely enhance the system performance. To be able to simulate such flows and correctly modelling the presence of a wall, we are resorting to diffuse-interface approaches. We will present an all-Mach pressure-based formulation, rooted in the Baer-Nunziato class of models, which relies on discontinuity capturing methods to account for the abrupt changes in the material properties between the two phases without any explicit imposition of the jump conditions at the interface location. Preliminary simulations of boiling on a smooth surface will be presented.https://cassyni-user-files-prod.s3.amazonaws.com/7rE8FNbPexExQmywvwFUMU https://cassyni.com/slides/outline/DvjJy4N9daqaGrgT9BwFFB https://cassyni.com/events/DvjJy4N9daqaGrgT9BwFFB/abstract https://cassyni-user-files-prod.s3.amazonaws.com/8jc2Ymw2DXWPT5rMCGw1XL https://cassyni.com/events/DvjJy4N9daqaGrgT9BwFFB?videoPreview=1 Translation and Indigenous Language Preservation in Indonesianohttps://cassyni.com/events/DvjJy4N9daqaGrgT9BwFFB?videoPreview=12022-11-11T03:00:00+00:003317.24Linguistics and Applied Language StudiesTranslation practices have existed since the 19th century involving several major Indonesian-type languages. However, those practices cannot be considered as related to indigenous language preservation. Before the Indonesian independence, different tribes in Indonesia were still independent and considered themselves as different nations. Therefore, a native language in those days was considered as a national language for a certain tribe or nation. The situation changed since the independence. Indonesia as a nation has many different tribes. Other than the national language (bahasa Indonesia), Indonesia has hundreds indigenous languages. In addition, since the Independence Day, bahasa Indonesia has become the dominant target language in the translation practices. In this talk, I will discuss some latest translation practices involving indigenous languages in Indonesia. I would like to argue in this presentation that translation can be one of the most potential solutions to preserve indigenous languages. In 2021, Indonesian government initiated a massive translation project; the Covid19 protocol guidance originally written in bahasa Indonesia was translated into 77 indigenous languages. In this presentation, I will present data from East Javanese for micro-discussion on the translation process. In addition, I will also talk about translation practices into indigenous languages that target younger generation. Efforts to translate children’s literature into indigenous languages have been initiated. Hopefully, this project can be developed and attract more translators to translate texts into their indigenous languages. Keywords: indigenous language, preservation, translation https://cassyni-user-files-prod.s3.amazonaws.com/8jc2Ymw2DXWPT5rMCGw1XL https://cassyni.com/slides/outline/WjAa97aQCCdmKRuEBwdGow https://cassyni.com/events/WjAa97aQCCdmKRuEBwdGow/abstract https://cassyni-user-files-prod.s3.amazonaws.com/4DMWMKa4zgUGCJxopvEMh8 https://cassyni.com/events/WjAa97aQCCdmKRuEBwdGow?videoPreview=1 Tickling Induces a Unique Type of Spontaneous Laughternohttps://cassyni.com/events/WjAa97aQCCdmKRuEBwdGow?videoPreview=12024-11-12T12:00:00+00:001171.4Royal Society PublishingLaughing is ubiquitous in human life, yet what causes it and how it sounds is highly variable. Considering this diversity, we sought to test whether there are fundamentally different kinds of laughter. Here, we sampled spontaneous laughs (n = 887) from wide range of everyday situations (for example, comedic performances and playful pranks). Machine learning analyses showed that laughs produced during tickling are acoustically distinct from laughs triggered by other kinds of events (verbal jokes, watching something funny, or witnessing someone else’s misfortune). In a listening experiment (n = 201), participants could accurately identify tickling-induced laughter, validating that such laughter is not only acoustically, but also perceptually distinct. A second listening study (n = 210) combined with acoustic analyses indicate that tickling-induced laughter involves less vocal control than laughter produced in other contexts. Together, our results reveal a unique acoustic and perceptual profile of laughter induced by tickling, an evolutionarily ancient play behaviour, distinguishing it clearly from laughter caused by other triggers. This study showcases the power of machine learning in uncovering patterns within complex behavioural phenomena, providing a window into the evolutionary significance of ticking-induced laughter.https://cassyni-user-files-prod.s3.amazonaws.com/4DMWMKa4zgUGCJxopvEMh8 https://cassyni.com/events/725C2w36XaygyD8u4GSwZo/abstract https://cassyni-user-files-prod.s3.amazonaws.com/V2w7vfqC3wHVxVNkptqvXG https://cassyni.com/slides/outline/Sn4c7XwrtczANxdXyLzPM7 https://cassyni.com/events/Sn4c7XwrtczANxdXyLzPM7/abstract https://cassyni-user-files-prod.s3.amazonaws.com/DNSRbG6DJQNSLTK9q72VrE https://cassyni.com/events/Sn4c7XwrtczANxdXyLzPM7?videoPreview=1 How to Square Microbial life in Solar Salternsnohttps://cassyni.com/events/Sn4c7XwrtczANxdXyLzPM7?videoPreview=12025-03-18T10:00:00+00:00898.0Microbiome Virtual International ForumMicrobial communities in hypersaline crystallizer ponds are amongst one of the best studied microbial ecosystems. Investigation of these extreme environments followed the scientific and technological developments in the past 50 + years ranging from the initial microscopy observations up to state-of-the-art molecular tools that have now become common practice. The hypersaline ecosystems are dominated by halophilic archaea but essentially contain members of all domains of life including viruses. One of the intriguing discoveries concerned the enigmatic square archaeon Haloquadratum walsbyi that initially resisted isolation for almost 25 years but was finally obtained into pure culture. In this short presentation I will focus on this specific isolate and its presence in its natural environment at the time of sampling. https://cassyni-user-files-prod.s3.amazonaws.com/DNSRbG6DJQNSLTK9q72VrE https://cassyni.com/slides/outline/25ePoMbcwjJDDWLoT8QHfT https://cassyni.com/events/25ePoMbcwjJDDWLoT8QHfT/abstract https://cassyni-user-files-prod.s3.amazonaws.com/PBwdpyLSNwr2V7KZD1q4F8 https://cassyni.com/events/25ePoMbcwjJDDWLoT8QHfT?videoPreview=1 An OpenFOAM-based solver for modeling low Mach number turbulent flows at high pressure with real-fluid effectsnohttps://cassyni.com/events/25ePoMbcwjJDDWLoT8QHfT?videoPreview=12025-09-01T07:53:45+00:001921.84Computer Physics CommunicationsNumerical simulations of non-reacting/reacting flows at supercritical pressure near the critical points with real-fluid models in OpenFOAM often encounter instability and divergence issues unless the solution algorithm incorporates special techniques. In this paper, we develop a novel pressure-based solver, realFluidFoam, tailored for simulations of subsonic turbulent flows at transcritical and supercritical conditions in OpenFOAM. The realFluidFoam solver utilizes unique algorithms to enhance the stability and convergency while taking into account real-fluid effects. Its source code and implementation details are provided to facilitate a comprehensive understanding of integrating real-fluid models into fluid flow simulations in OpenFOAM. The realFluidFoam solver is validated against experimental data by performing large-eddy simulations (LESs) of liquid nitrogen injection and coaxial liquid nitrogen/preheated hydrogen injection under transcritical and supercritical conditions. The LES results show a satisfactory agreement with the experimental data, verifying that the realFluidFoam solver can accurately simulate transcritical and supercritical turbulent fluid flows over the wide range of pressure, especially near the critical points.https://cassyni-user-files-prod.s3.amazonaws.com/PBwdpyLSNwr2V7KZD1q4F8 https://cassyni.com/events/YCmuucLLgFBPFac8F1BwvM/abstract https://cassyni-user-files-prod.s3.amazonaws.com/GxhTXE54NPwFsQK3tUPnkE https://cassyni.com/events/YCmuucLLgFBPFac8F1BwvM?videoPreview=1 NOTCH1 signaling is dysregulated by loss of the deubiquitinase USP28 with del(11q), uncovering USP28 inhibition as novel therapeutic target in CLLnohttps://cassyni.com/events/YCmuucLLgFBPFac8F1BwvM?videoPreview=12025-06-30T11:00:00+00:001506.48LeukemiaAberrant active NOTCH1 signaling is a key pathogenic factor in chronic lymphocytic leukemia (CLL), detectable in half of patients and associated with disease progression. While some cases of active NOTCH1 signaling can be explained by mutations in NOTCH1 or its regulators, like FBXW7, alternative mechanisms remain elusive. Here, we identified the deubiquitinase USP28 as regulator of NOTCH1 signaling in CLL. Notably, USP28 is located within the frequently deleted chr11q23 region and is deleted in 90% of del(11q) patients, resulting in its decreased expression. USP28 interacts with the NOTCH1 intracellular domain (NICD) independently of FBXW7 and the NICD-PEST domain, stabilizing NICD and enhancing NOTCH1 signaling. Integrating RBPJ-occupied genes in HG3 cells, RNA-Seq of USP28WT/KO cells and gene expression from del(11q) CLL patients, we identified 15 NOTCH1 target genes specifically dysregulated by deletion of USP28 and del(11q) potentially influencing CLL pathogenesis. Pharmacological inhibition of USP28 with the small molecule AZ1 suppressed NOTCH1 activation in primary CLL cells. AZ1 combined with the BCL-2 inhibitor venetoclax reduced CLL cell viability, particularly in samples with high NOTCH1 activity. Our findings highlight USP28 as promising therapeutic target and provide a rationale for combined inhibition of USP28 and BCL-2 in CLL patients with active NOTCH1 signaling.https://cassyni-user-files-prod.s3.amazonaws.com/GxhTXE54NPwFsQK3tUPnkE https://cassyni.com/events/CwugpPqAboUgjnAq4fdycH/seminar/qa https://cassyni.com/slides/outline/CwugpPqAboUgjnAq4fdycH https://cassyni.com/events/CwugpPqAboUgjnAq4fdycH/abstract https://cassyni-user-files-prod.s3.amazonaws.com/9SM5Sg5KAywDBo13trEbLJ https://cassyni.com/slides/outline/KrbRs9g77AGJBbpwUKTPh7 https://cassyni.com/events/KrbRs9g77AGJBbpwUKTPh7/abstract https://cassyni-user-files-prod.s3.amazonaws.com/K6FT2tJmxrrmjvo3EfAb2v https://cassyni.com/events/KrbRs9g77AGJBbpwUKTPh7?videoPreview=1 Goodbye Christoffel Symbols: A Flexible and Practical Approach for Solving Physical Problems in Curved Spacesnohttps://cassyni.com/events/KrbRs9g77AGJBbpwUKTPh7?videoPreview=12025-07-05T15:00:00+00:00980.72Computer Physics CommunicationsTraditional methods for solving physical equations in curved spaces, particularly in areas like fluid dynamics and continuum mechanics, often face significant complexity due to the necessity of incorporating Christoffel symbols to account for spatial curvature. These symbols complicate the formulation and numerical implementation. In this paper, we present a novel and flexible methodology that entirely obviates the need for Christoffel symbols by fundamentally changing the approach to problem formulation and solution. The method operates by formulating the physical problem directly within a Euclidean 3D Cartesian space, where differential operators are standard and well-defined. The core of our innovation lies in the combined and systematic application of symbolic calculus to perform both the necessary chain rule transformations between the physical curved space and the embedding Euclidean space, and the subsequent projection operations. This powerful symbolic framework allows us to effectively derive and solve the governing equations on the curved geometry without explicitly computing or using Christoffel symbols or specialized curved-space operators. We demonstrate the robustness, flexibility, and advantages of this approach through several examples, including the derivation of the Navier-Stokes equations in cylindrical coordinates, the modeling of complex flows in bent cylindrical tubes, and the simulation of the breakup of viscoelastic threads. These examples highlight the method's ability to simplify the mathematical formulation and provide a robust framework for complex or evolving geometries. The flexibility in choosing basis representations within the Euclidean space is also shown to offer potential benefits for numerical stability in certain applications.https://cassyni-user-files-prod.s3.amazonaws.com/K6FT2tJmxrrmjvo3EfAb2v https://cassyni.com/slides/outline/DvqoRaRhF2YUrTtDKd5gYV https://cassyni.com/events/DvqoRaRhF2YUrTtDKd5gYV/abstract https://cassyni-user-files-prod.s3.amazonaws.com/QjaX4zbiawNEH4t6wQxSt6 https://cassyni.com/events/DvqoRaRhF2YUrTtDKd5gYV?videoPreview=1 GPR calculator: An On-the-Fly Surrogate Model to Accelerate Massive Nudged Elastic Band Calculationsnohttps://cassyni.com/events/DvqoRaRhF2YUrTtDKd5gYV?videoPreview=12025-08-22T15:00:00+00:001577.56Computer Physics CommunicationsThe role of computational modeling approaches has become increasingly important in the design of catalysts. Developing reliable computational models requires a fundamental understanding of catalytic surface reactions, particularly the relevant elementary steps and their associated kinetics such as activation barriers and reaction rates. A widely used approach to study surface reactions is the identification of the minimum energy pathway (MEP), typically computed using the nudged elastic band (NEB) method. In the NEB method, the MEP is initialized as a discrete chain of configurations (images) connecting two local minima. Usually 5-10 images are employed, and their positions iteratively adjusted during the optimization. Converging to the desired MEP often requires hundreds of steps, translating to hundreds of energy and force evaluations per image using electronic structure methods—most commonly density functional theory (DFT). Each electronic structure evaluation typically takes tens or even hundreds of CPU minutes, making NEB calculations very computationally demanding. To address this computational bottleneck, we introduce a GPR_calculator, a package based on Python and C++ languages to build an on-the-fly surrogate model Gaussian Process Regression (GPR) to approximate the expensive electronic structure calculations. The GPR model dynamically trains during simulations, predicting energies and forces with uncertainty quantification. When uncertainty is high, electronic structure calculations are performed to obtain ground truth data to update the GPR model. We demonstrate the effectiveness of the GPR_calculator, on several catalytic surface reactions, achieving 3-5 times acceleration compared to conventional NEB calculations that rely solely on DFT. The source code is available at https://github.com/MasterSim/GPR_calculator.https://cassyni-user-files-prod.s3.amazonaws.com/QjaX4zbiawNEH4t6wQxSt6 https://cassyni.com/slides/outline/ERX2atb75r2Jfvsj7jCeih https://cassyni.com/events/ERX2atb75r2Jfvsj7jCeih/abstract https://cassyni-user-files-prod.s3.amazonaws.com/KDbj9w3jnioNTcqyTBRwQr https://cassyni.com/events/ERX2atb75r2Jfvsj7jCeih?videoPreview=1 Clinical relevance of circulating tumor DNA in HER2-positive advanced gastric cancernohttps://cassyni.com/events/ERX2atb75r2Jfvsj7jCeih?videoPreview=12025-09-07T07:00:00+00:00692.04Sage PublishingBackground: The combination of anti–programmed cell death-1 antibody with human epidermal growth factor receptor 2 (HER2)–targeted therapy and chemotherapy is widely used in the United States and Europe for HER2-positive advanced gastric cancer (AGC). Molecular profiles that predict the efficacy of this dual-target therapy are unclear. Objectives: To explore the clinical utility of circulating tumor DNA (ctDNA) as a predictive marker of the efficacy of standard chemotherapy plus HER2 and programmed death-ligand 1 dual-targeted therapy in patients with HER2-positive AGC. Design: Collaborative study of the Ni-High phase Ib clinical trial. Methods: A total of 21 patients with tissue-confirmed HER2-positive AGC who received chemotherapy with dual-targeted therapy (capecitabine/S-1, oxaliplatin, trastuzumab, and nivolumab) in a phase Ib clinical trial (UMIN000034222) were enrolled. The association of genomic profiles in plasma ctDNA with tissue HER2 amplification status and their correlation with clinical outcomes were investigated. Results: Among the 21 patients studied, 20 (95.2%) showed somatic alterations in ctDNA. ERBB2 amplifications and single nucleotide variants (SNVs)/indels were found in 12 (57.1%) and 3 (14.3%) patients, respectively. Significant associations between maximum mutant allele frequency (mMAF) and tumor size and between ctDNA and tissue ERBB2 copy numbers were found. Patients without ERBB2 SNV/indels showed longer median progression-free survival (PFS) and overall survival (OS) than those with these alterations. Patients with focal ERBB2 amplification in ctDNA showed better outcomes than those with aneuploidy (median PFS: 20.8 vs. 8.4 months, hazard ratio [HR] = 0.08; median OS: NA vs. 14.8 months, HR = 0.077). Lower mMAF at cycle 2 was associated with a better response to chemotherapy with dual-targeted therapy. Conclusions: ERBB2 genetic status and mMAF changes in ctDNA may respectively predict and reflect the efficacy of chemotherapy with dual-targeted therapy in HER2-positive AGC.https://cassyni-user-files-prod.s3.amazonaws.com/KDbj9w3jnioNTcqyTBRwQr https://cassyni.com/slides/outline/EvAddaEdXJaMfhQciAVSz1 https://cassyni.com/events/EvAddaEdXJaMfhQciAVSz1/abstract https://cassyni-user-files-prod.s3.amazonaws.com/EdGXsW89fjsZwhgp42xdtz https://cassyni.com/events/EvAddaEdXJaMfhQciAVSz1?videoPreview=1 CFTR modulator therapy drives microbiome restructuring through improved host physiology in cystic fibrosis: the IMMProveCF phase IV trialnohttps://cassyni.com/events/EvAddaEdXJaMfhQciAVSz1?videoPreview=12026-02-10T00:30:00+00:00332.52Microbiome Virtual International ForumCystic fibrosis (CF) is a genetic disorder caused by mutations in the CFTR gene, leading to impaired CFTR function, mucus accumulation, chronic infections, and inflammation. The triple combination elexacaftor/tezacaftor/ivacaftor (ETI) has transformed CF treatment by restoring CFTR function. However, how ETI-induced physiological improvements affect long-standing dysbiosis and pathogen colonization across microbiome habitats remains poorly understood. In this prospective longitudinal study (DRKS00023862), we analyzed sputum, throat, and stool microbiomes of pwCF (n = 35) before and after ETI initiation, alongside healthy controls (n = 49). The primary endpoint was longitudinal change in diversity, species richness, and microbial composition in the respiratory and intestinal microbiome, profiled by 16S rRNA gene sequencing. Secondary endpoints included changes in lung function, systemic and gastrointestinal inflammation. We show how improved CFTR function and direct antibacterial effects of ETI create a niche disadvantage for Staphylococcus in the sputum microbiome. Respiratory microbiome shifts were immediate, while gut changes emerged gradually. Escherichia abundance in stool, initially elevated in pwCF, decreased post-ETI and correlated with lower fecal calprotectin. These findings demonstrate that ETI can partially reverse CF-associated dysbiosis through improved host physiology. They offer insights into host-microbiome dynamics under therapeutic modulation and emphasize the need for confounder-aware models in complex clinical populations.https://cassyni-user-files-prod.s3.amazonaws.com/EdGXsW89fjsZwhgp42xdtz https://cassyni.com/events/LLCzgYFqeGYWQoGHfyeFHX/abstract https://cassyni-user-files-prod.s3.amazonaws.com/7EKfQcTXoxfGzmNi6mSsvE https://cassyni.com/slides/outline/JrHof7q9jFots6K8Wq9P17 https://cassyni.com/events/JrHof7q9jFots6K8Wq9P17/abstract https://cassyni-user-files-prod.s3.amazonaws.com/EeDnY71jmAp7W4DeLNgvf8 https://cassyni.com/events/JrHof7q9jFots6K8Wq9P17?videoPreview=1 Functionalized Carbon Nanotubes as Smart Carriers for Cardiovascular Drugs: A DFT Perspective on Hydralazine Adsorptionnohttps://cassyni.com/events/JrHof7q9jFots6K8Wq9P17?videoPreview=12025-11-18T17:05:15+00:002826.36Chemical Physics ImpactThe adsorption behavior of the vasodilator drug Hydralazine on pristine and COOH-functionalized single-walled carbon nanotubes (SWCNTs) has been investigated in this study using density functional theory (DFT) at the M06/6-31G* level. The electronic and thermodynamic properties were calculated based on optimized structures using Gaussian 09 software. The bonding analysis revealed that hydrogen bonding between Hydralazine and functionalized SWCNT (f-SWCNT), modified by the addition of a carboxyl group at one end, exhibits stronger adsorption of Hydralazine (–18.167 kcal/mol) compared to pristine SWCNT (–7.228 kcal/mol). The HOMO-LUMO gap decreased from 0.516 eV (pristine) to 0.433 eV (functionalized), indicating enhanced electronic interactions. Natural Bond Orbital (NBO) analysis confirmed stronger donor–acceptor charge transfer for f-SWCNT, while Atoms in Molecules (AIM) and NCI-RDG analysis indicated cooperative hydrogen-bonding and weak covalent contributions to the adsorption mechanism. Thermodynamic results (ΔH < 0, ΔG < 0) showed that the adsorption processes are spontaneous and exothermic, and the formed complexes are stable at standard conditions. These findings suggest that while both pristine and functionalized SWCNTs can act as effective adsorbents for Hydralazine, COOH-functionalized SWCNTs demonstrate superior adsorption capacity and potential as promising nanocarriers for drug delivery applications.https://cassyni-user-files-prod.s3.amazonaws.com/EeDnY71jmAp7W4DeLNgvf8 https://cassyni.com/events/7VNubPx5dj4uarKz9qhbzD/abstract https://cassyni-user-files-prod.s3.amazonaws.com/PS5CY3FH4A4NDqJybcf3sc https://cassyni.com/slides/outline/42qgGcRQZXCGZA2RWBKeTP https://cassyni.com/events/42qgGcRQZXCGZA2RWBKeTP/abstract https://cassyni-user-files-prod.s3.amazonaws.com/55VKBWxEmESPSpU2oWQYs8 https://cassyni.com/events/42qgGcRQZXCGZA2RWBKeTP?videoPreview=1 The bitter ‘reality’ of fungal disease in Miles Joseph Berkeley’s ‘Vegetable Pathology’, 1854–1857nohttps://cassyni.com/events/42qgGcRQZXCGZA2RWBKeTP?videoPreview=12026-02-20T20:00:00+00:002435.6Royal Society PublishingCash crops, such as sugarcane and coffee, played a key role in imperial Britain’s economy and political stability. So did food staples like wheat and potatoes. In the nineteenth century, these crops increasingly fell victim to fungal pathogens (and a number of non-fungal organisms mistaken for fungi at the time). This paper explores the Rev. Miles Joseph Berkeley’s (1803–1889) researches into such plant-pathogenic fungi. Quite correctly, Berkeley believed that fungal epidemics were related to the practices advocated by transimperial botany, including plantation monoculture and plant transfers.https://cassyni-user-files-prod.s3.amazonaws.com/55VKBWxEmESPSpU2oWQYs8 https://cassyni.com/events/EQTNEy1Rn8ph5fKZXHGY8u/abstract https://cassyni-user-files-prod.s3.amazonaws.com/9MbVTCkRqZHTkpS7n9fGXg https://cassyni.com/slides/outline/AwZ3RznEUEuWo1rVNCJ3cH https://cassyni.com/events/AwZ3RznEUEuWo1rVNCJ3cH/abstract https://cassyni-user-files-prod.s3.amazonaws.com/CQ9WG6vyzzhK7Pw5VuVJmc https://cassyni.com/events/AwZ3RznEUEuWo1rVNCJ3cH?videoPreview=1 Conservation in action: Describing the hearing and anatomy of the ear to eventually help European hedgehogs avoid getting squashed by cars nohttps://cassyni.com/events/AwZ3RznEUEuWo1rVNCJ3cH?videoPreview=12026-03-26T02:00:00+00:001290.08Royal Society PublishingA major threat to the declining European hedgehog (Erinaceus europaeus), is road traffic. Devising methods to reduce the number of collisions would increase hedgehog welfare in an urbanised world, and serve to protect this flagship species, and this goal might be advanced by an understanding of their hearing. This study investigates the auditory capabilities and anatomy of the ear of the European hedgehog. Using auditory brainstem response (ABR) testing on 20 live hedgehogs from Danish wildlife rescue centres, we measured hearing thresholds across 4-85 kHz, and found a peak sensitivity around 40 kHz, revealing that European hedgehogs can hear sound frequencies of at least 4-85 kHz. Complementary post mortem micro-CT scans enabled a detailed 3D reconstruction of the inner ear, revealing small middle ear bones with a cochlear spiral of approximately 1.7 turns. Results show that hedgehogs can perceive a broad ultrasonic range, which provides important cues for directional hearing and may additionally function in prey detection and communication. These findings provide critical insights into hedgehog sensory biology and inform the potential development of ultrasonic repellents to mitigate traffic collisions and habitat disturbances, contributing to conservation strategies for this declining species.https://cassyni-user-files-prod.s3.amazonaws.com/CQ9WG6vyzzhK7Pw5VuVJmc https://cassyni.com/slides/outline/9TyKn8YBPZHfgZcDWoZYQm https://cassyni.com/events/9TyKn8YBPZHfgZcDWoZYQm/abstract https://cassyni-user-files-prod.s3.amazonaws.com/UPjLVQsWYd3UAJVMHH7djU https://cassyni.com/events/9TyKn8YBPZHfgZcDWoZYQm?videoPreview=1 A highly accurate risk factor-based XGBoost multiethnic model for identifying patients with skin cancernohttps://cassyni.com/events/9TyKn8YBPZHfgZcDWoZYQm?videoPreview=12025-11-28T15:00:00+00:001063.8Research Seminars by Springer NatureWhile individuals of European descent have a higher risk of skin cancer, other ancestries tend to have more advanced disease at diagnosis, resulting in outcome disparities. We examine the diverse All of Us dataset and identify genetic ancestries, lifestyle, social determinants of health and PDE5a inhibitor use as independent risk factors for skin cancer. We integrate these risk factors into a highly accurate XGBoost multiethnic model for identifying patients with skin cancer. Analyses of Shapley scores and interactions indicate the presence of strong non-linear associations between age and other risk factors, in particular cancer history, genetic ancestry and annual income, and suggest a stronger dependence on genetic and social determinants in younger individuals. Our XGBoost multiethnic model offers a precision medicine approach for early skin cancer detection in ethnically diverse patients, which could reduce outcome disparities in individuals of non-European ancestries.https://cassyni-user-files-prod.s3.amazonaws.com/UPjLVQsWYd3UAJVMHH7djU https://cassyni.com/slides/outline/Gsj1b1kwNnXEKcq5mFMiTP https://cassyni.com/events/Gsj1b1kwNnXEKcq5mFMiTP/abstract https://cassyni-user-files-prod.s3.amazonaws.com/JpPS4XkHpf7YLJb7RSvfJN https://cassyni.com/events/Gsj1b1kwNnXEKcq5mFMiTP?videoPreview=1 Space Astrometry with Gaia: Advances in Understanding our Galaxynohttps://cassyni.com/events/Gsj1b1kwNnXEKcq5mFMiTP?videoPreview=12026-02-15T08:00:00+00:002007.52Physics ReportsGaia is a satellite mission of the European Space Agency which is creating a catalogue of extremely accurate positions, distances and space motions of two billion stars in our Galaxy, along with more than one hundred thousand solar system asteroids, and several million distant quasars, all on the same extragalactic reference system. Complementary information on each object's multi-epoch photometry and spectra provides a vast and unprecedented data base of (model-dependent) fundamental physical quantities, such as each star's mass, age, and chemical composition. I outline the field's historical context, and explain the key principles involved in these space measurements. This is followed by a broad review of the many areas of solar system science, stellar structure and evolution, and topics in Galactic structure, evolution, and dynamics, that are being derived from these data.https://cassyni-user-files-prod.s3.amazonaws.com/JpPS4XkHpf7YLJb7RSvfJN https://cassyni.com/slides/outline/Rm4R3mDkShNgkM4SnBn7yo https://cassyni.com/events/Rm4R3mDkShNgkM4SnBn7yo/abstract https://cassyni-user-files-prod.s3.amazonaws.com/2fKU9DMtZvn3JCuGDUkfGz https://cassyni.com/events/Rm4R3mDkShNgkM4SnBn7yo?videoPreview=1 Sex differences in the enjoyment of enrichment: Affective bias testing confirms female rats prefer more playful and less vigorous ticklingnohttps://cassyni.com/events/Rm4R3mDkShNgkM4SnBn7yo?videoPreview=12026-04-06T13:00:00+00:00878.36Royal Society PublishingThere is increasing interest in positive animal welfare which emphasises that animals should experience predominantly positive mental states. Positive animal welfare raises challenging biological questions including how we assess positive experiences. Rat tickling mimics rough and tumble play; it is applied to improve welfare and study positive affect, often using ultrasonic vocalisations (USVs) to assess rats’ affective state. Standard tickling protocols involve frequent pinning where the supine rat is vigorously tickled on its belly, which we have argued may not be positive for all rats. Here, using an Affective Bias Test (ABT), we show that both sexes experience positive affective states when tickled, but females, unlike males, prefer playful tickling with minimal pinning. This result corresponds with our previous work using USVs to assess rats’ affective response to tickling, further validating USV recording as a marker of positive affective states. We believe this to be the first example where a refinement aimed at enhancing positive, rather than minimising negative, mental states in animals has been independently validated; this should provide a model for similar studies in other species. In rats, this refinement should enhance welfare and more generally demonstrates the importance of considering sex differences when designing welfare interventions. https://cassyni-user-files-prod.s3.amazonaws.com/2fKU9DMtZvn3JCuGDUkfGz https://cassyni.com/slides/outline/51q3743i1U7RcMcAW4rn6H https://cassyni.com/events/51q3743i1U7RcMcAW4rn6H/abstract https://cassyni-user-files-prod.s3.amazonaws.com/7Mg7TNfD5czJn51K1D1bW6 https://cassyni.com/events/51q3743i1U7RcMcAW4rn6H?videoPreview=1 First direct quantification of floral handling costs in beesnohttps://cassyni.com/events/51q3743i1U7RcMcAW4rn6H?videoPreview=12026-03-26T10:00:00+00:00586.96Royal Society PublishingFloral handling can be energetically costly for bees, yet these costs are rarely measured. We provide the first direct quantification of the metabolic cost of floral buzzing in bumblebees and evaluate its ecological significance. Using flow-through respirometry synchronised with laser vibrometry, we measured carbon dioxide production during floral buzzing by Bombus terrestris and compared it with flight take-off, which is powered by the same thoracic muscles. Floral buzzing required high muscular effort compared to other behaviours, with ~0.10 J per event and mass-specific power ~293 W/kg. Overall costs were comparable to take-off because floral buzzing bouts are longer despite a lower metabolic rate. Metabolic rate scaled with body mass, whereas intertegular span did not, implying that transient load rather than structural size better explains energetic demand in short, high-intensity behaviours. Metabolic traits were highly repeatable within individuals, but variable between individuals, and colony identity also explained additional variance. Converting costs to nectar equivalents showed that floral buzzing required slightly more nectar than take-off and that requirements rose as nectar sugar concentration declined. We conclude that floral buzzing is a major, previously unquantified component of bee energy budgets that is likely to shape nectar demands, flower visitation patterns, and generally plant–pollinator interactions.https://cassyni-user-files-prod.s3.amazonaws.com/7Mg7TNfD5czJn51K1D1bW6 https://cassyni.com/slides/outline/Eto82izCndBkTscC1dd9ED https://cassyni.com/events/Eto82izCndBkTscC1dd9ED/abstract https://cassyni.com/events/Eto82izCndBkTscC1dd9ED?videoPreview=1 Bumblebee queens are better at olfactory learning and more sensitive to scents than workers nohttps://cassyni.com/events/Eto82izCndBkTscC1dd9ED?videoPreview=12026-04-08T19:00:00+00:001010.92Royal Society PublishingDifferences in cognition within a species can reflect ecological demands, but performance in learning tasks may also be influenced by non-cognitive factors like sensitivity to stimuli. Bumblebees are a well-established model for studying learning, especially their ability to associate cues with rewards, but most research has focused on foraging workers. Queen bumblebees also forage, and previous studies have shown that they learn visual associations with fewer errors than workers. In this study, we asked whether queens’ stronger learning performance also extends to smell, and whether their larger body size might enhance their sensory sensitivity in ways that could explain these differences. We first tested olfactory learning in wild Bombus vosnesenskii and found that queens made fewer errors than workers. However, after additional training and sensitivity tests, queens and workers performed similarly, suggesting that differences in learning were not explained by non-cognitive factors. In a second experiment using Bombus impatiens under controlled conditions, we found that queens were also more sensitive to scents than workers, but their better learning abilities cannot be explained by this alone. Our results further support learning differences between queens and workers, which may reflect the different ecological roles and challenges each caste faces during their lives. https://cassyni.com/slides/outline/QH9E2Lo4XgdkU6mjDL39jT https://cassyni.com/events/QH9E2Lo4XgdkU6mjDL39jT/abstract https://cassyni-user-files-prod.s3.amazonaws.com/F3BP5zs9Qsj1FpriDud3Kc https://cassyni.com/events/QH9E2Lo4XgdkU6mjDL39jT?videoPreview=1 A Talk on Narrative Matters: Vulnerable Bodies and Australian Climate Fictionnohttps://cassyni.com/events/QH9E2Lo4XgdkU6mjDL39jT?videoPreview=12026-04-07T12:00:00+00:002828.36Public HumanitiesFrom Australia—where urgent climate crisis meets enduring colonial legacies—we present our ongoing research into how environmental shifts are transforming scientific, literary-cultural, and philosophical discourses. We contend that humanities frameworks offer essential tools for confronting current climate inaction by deconstructing the foundational discourses of Western culture that sustain it. Among the interrelated discourses our model examines, we focus specifically on narratives of salvation, the concept of the ‘invulnerable’ body, and the ways human and non-human bodies are rendered vulnerable through the power dynamics and material conditions of the climate crisis. In this conversation, we turn to Ellen van Neerven’s story “Water” from Heat and Light (2014). We look at how a piece of fiction like this can take apart the dominant symbols and stories we're stuck with.https://cassyni-user-files-prod.s3.amazonaws.com/F3BP5zs9Qsj1FpriDud3Kc https://cassyni.com/events/NJaRxEirBDM5vvsXRarpQu/abstract https://cassyni-user-files-prod.s3.amazonaws.com/MzGe8HRHKtgb1enFx8cePg https://cassyni.com/events/HNgTtd5DFDGKbZCmTCFmid/abstract https://cassyni-user-files-prod.s3.amazonaws.com/eo6zQnQX9kahJ6Rw9onBQ https://cassyni.com/events/HNgTtd5DFDGKbZCmTCFmid?videoPreview=1 Disruption score and its impactnohttps://cassyni.com/events/HNgTtd5DFDGKbZCmTCFmid?videoPreview=12026-09-15T14:15:00+00:001068.88Microbiome Virtual International ForumPendinghttps://cassyni-user-files-prod.s3.amazonaws.com/eo6zQnQX9kahJ6Rw9onBQ https://cassyni.com/events/14j55URAhtTpgBvKFJqDrd/abstract https://cassyni-user-files-prod.s3.amazonaws.com/4hamgZVJPj8ThRYEeFRQyt https://cassyni.com/slides/outline/FtBCTypusd5AvodgmMJaih https://cassyni.com/events/FtBCTypusd5AvodgmMJaih/abstract https://cassyni-user-files-prod.s3.amazonaws.com/9sMTpdk3U9kJXsiSFtdZNE https://cassyni.com/events/FtBCTypusd5AvodgmMJaih?videoPreview=1 No evidence of fine-scale local adaptation of winter moths to variable tree phenologynohttps://cassyni.com/events/FtBCTypusd5AvodgmMJaih?videoPreview=12026-07-27T10:00:00+00:001181.8Royal Society PublishingSpatial variation in plant phenology can impose strong selective pressures on herbivorous insects whose fitness relies on synchrony with host plants, promoting local adaptation to host timing. Winter moths (Operophtera brumata) have been shown to synchronise egg hatching with host budburst, but whether this reflects local adaptation remains unclear. We used three complementary approaches to assess small-scale local adaptation of winter moths to oak phenology in Wytham Woods, UK, a 385-hectare woodland with repeatable variation in individual oak budburst phenology. We experimentally investigated whether host tree phenology predicts hatch timing using common gardens across multiple temperatures, evaluated fitness benefits of synchrony using translocations, and assessed population structure and gene-environment associations using whole-genome sequencing. We found no support for local adaptation to individual trees. Common garden experiments revealed systematic differences in hatch timing which were unrelated to host budburst, while translocations indicated no fitness consequences of asynchrony. Genetic analyses showed no detectable population structure or association with budburst timing. Local adaptation to host phenology therefore appears not to arise on individual trees but may instead occur at broader spatial scales. Understanding the scale of local adaptation is essential for predicting how insect-plant synchrony will respond to environmental change across heterogeneous landscapes.https://cassyni-user-files-prod.s3.amazonaws.com/9sMTpdk3U9kJXsiSFtdZNE https://cassyni.com/slides/outline/AT3YxTi93az6XwPTASJnjF https://cassyni.com/events/AT3YxTi93az6XwPTASJnjF/abstract https://cassyni-user-files-prod.s3.amazonaws.com/3opm5L8UDcVW9aQmeMBt9t https://cassyni.com/events/AT3YxTi93az6XwPTASJnjF?videoPreview=1 Thermally regulated green living wallnohttps://cassyni.com/events/AT3YxTi93az6XwPTASJnjF?videoPreview=12026-09-17T10:00:00+00:001232.76Cassyni SeminarsGreen living walls can improve the aesthetic quality of a building and moderate the temperature within it. The purpose of this paper is to examine whether the green wall has any effect on the interior temperature of the building in the hot and cold months of the year. Temperatures on an outside wall as well as on research and control areas were monitored to capture temperature data for a one-year period that encompassed all seasons: sunny, cold and wet. The findings of this research contribute to the knowledge of the effects provided by green living walls in terms of cooling and heating, the influence on the proximity microclimatic conditions, and overall energy transfer. Heat flux of 20–100 W/m2 was found indicating an insulating effect that brings about cooling in the interior of the building. During summer months a cooling effect of 2–4 °C was observed, while the opposite effect was observed during winter in that the temperatures did not drop by much but provide a insulating effect of 2–3 °C higher than it was for the control area. Altogether, green living walls could be implemented to reduce and insulating interior living conditions and therefore reduce building energy demands. https://cassyni-user-files-prod.s3.amazonaws.com/3opm5L8UDcVW9aQmeMBt9t https://cassyni.com/events/Pnc7SBD5hfnZPKr4ouDiwX/abstract https://cassyni-user-files-prod.s3.amazonaws.com/EaJH3rg38XrGnie6iYa2mC https://cassyni.com/slides/outline/JMUTvf6JsdhUzTbqCzDvx5 https://cassyni.com/events/JMUTvf6JsdhUzTbqCzDvx5/abstract https://cassyni-user-files-prod.s3.amazonaws.com/FAepGTM6gxRy9AE5dyuU6J https://cassyni.com/events/JMUTvf6JsdhUzTbqCzDvx5?videoPreview=1 A Review of Cavitation nohttps://cassyni.com/events/JMUTvf6JsdhUzTbqCzDvx5?videoPreview=12026-07-28T04:00:00+00:001666.08Physics ReportsThe proliferation of supercavitation simulation strategies and cavitation models for external flows has created a critical need for a unified framework that connects classical theory with modern computational and experimental evidence. This Part I review meets that need by first surveying prior cavitation review articles from 1977 to the present to establish historical context, terminology, and persistent open problems. Building on that foundation, we consolidate core concepts for external flows, standardize terminology for cavity formation, closure, and scaling, and organize models by their physical basis. We then evaluate three classes of models: Rayleigh–Plesset-based​ mass-transfer closures, homogeneous-mixture formulations, and Eulerian–Lagrangian event-rate approaches. Each class is evaluated against core validation metrics, which include cavity geometry, pressure signatures, and inception statistics. The results show that homogeneous-mixture models accurately capture the dynamics of sheets and clouds. Coupling to a population balance improves onset prediction in ambient and cryogenic conditions. Event rate methods bracket the measured inception rates when screening is explicitly modeled. For supercavitation, the synthesis confirms that cavity shape control and gravity bias drive drag reduction, ventilated hysteresis is highly reproducible across facilities, and accurate geometry prediction requires modeling gas compressibility. The review concludes with a practical model selection guide that explicitly balances computational cost with predictive accuracy across different engineering scenarios, along with a reproducibility checklist for experimental and numerical studies, offering actionable guidance for researchers.https://cassyni-user-files-prod.s3.amazonaws.com/FAepGTM6gxRy9AE5dyuU6J https://cassyni.com/slides/outline/51y9gCd92Gk4M3g1tkAKUZ https://cassyni.com/events/51y9gCd92Gk4M3g1tkAKUZ/abstract https://cassyni-user-files-prod.s3.amazonaws.com/93mPSHBNTeXahoyvNegtar https://cassyni.com/events/51y9gCd92Gk4M3g1tkAKUZ?videoPreview=1 Beyond Solidarity: Why Global Health Needs the Concept of Convergencenohttps://cassyni.com/events/51y9gCd92Gk4M3g1tkAKUZ?videoPreview=12026-08-23T08:00:00+00:001333.44Public HumanitiesSolidarity has become one of the defining concepts in global health, frequently invoked to encourage collective action in response to pandemics, health inequities, and other transnational challenges. Yet contemporary collaborations increasingly bring together actors with different histories, priorities, values, and institutional interests. How, then, should we understand cooperation when deep agreement or shared identity is absent? In this talk, I argue that while solidarity remains an essential ethical and political ideal, it does not always fully capture how collaboration unfolds in practice. Drawing on interdisciplinary scholarship, I examine three recurring tensions in influential conceptualisations of solidarity: their reliance on shared identities or interests, their tendency to overlook internal power asymmetries, and their susceptibility to political and institutional co-optation. Building on these critiques, I introduce convergence as a complementary concept for understanding coordinated action among actors who align around shared objectives despite continuing differences. I also propose the idea of solidaristic convergence, which combines the practical logic of convergence with ethical commitments to inclusion, accountability, and attention to power. This presentation invites researchers, practitioners, and policymakers to rethink how collective action is conceptualised and organised in an increasingly interconnected and pluralistic world.https://cassyni-user-files-prod.s3.amazonaws.com/93mPSHBNTeXahoyvNegtar https://cassyni.com/events/EQHdZBv7MyGLCo99osdtMB/abstract https://cassyni-user-files-prod.s3.amazonaws.com/Co6Di8bbqoh4fYYAF1SWU6 https://cassyni.com/slides/outline/Qo3rDMdU6NssVYRDgqaKUH https://cassyni.com/events/Qo3rDMdU6NssVYRDgqaKUH/abstract https://cassyni-user-files-prod.s3.amazonaws.com/FbsZu9DuY2ZUDno4bEc2KY https://cassyni.com/events/Qo3rDMdU6NssVYRDgqaKUH?videoPreview=1 Researcher’s Toolkit: Practical Tips on ABS Compliance - Part 2nohttps://cassyni.com/events/Qo3rDMdU6NssVYRDgqaKUH?videoPreview=12025-05-05T10:00:00+00:001095.44Microbiome Virtual International ForumPart. 2 - The process for ensuring compliance with Access and Benefit Sharing (ABS) regulations under the Nagoya Protocol will be briefly outlined with practical guidance provided. It is essential to first assess whether the material in question falls under ABS legislation, particularly if it originates from countries asserting sovereign rights over their genetic resources. Where applicable, authorization must be obtained through Prior Informed Consent and Mutually Agreed Terms. Appropriate documentation—such as the Internationally Recognized Certificate of Compliance and Material Transfer Agreement—must be secured. https://cassyni-user-files-prod.s3.amazonaws.com/FbsZu9DuY2ZUDno4bEc2KY https://cassyni.com/slides/outline/MprNgL5a2fMy88ER3VXXXB https://cassyni.com/events/MprNgL5a2fMy88ER3VXXXB/abstract https://cassyni-user-files-prod.s3.amazonaws.com/8hzneoWc22Cfy1whnv86iS https://cassyni.com/events/MprNgL5a2fMy88ER3VXXXB?videoPreview=1 So many dynamoS: The Generation of Magnetic Fields in Planets and Starsnohttps://cassyni.com/events/MprNgL5a2fMy88ER3VXXXB?videoPreview=12023-10-05T12:00:00+00:003816.6The Edinburgh Fluid Dynamics Group (EFDG)The generation of magnetic field in Earth's interior and the origin of the eleven year solar cycle are both thought to lie in dynamo action of an electrically conducting fluid. In both cases fluid motions interact with rotation to sustain electrical currents and hence magnetic field. In this talk I will give an introduction to some interesting problems for a fluid dynamicist in trying to explain the generation of magnetic field and I will highlight some differences between the geo- and solar dynamo problems. I'll conclude by drawing an analogy of the geodynamo problem with transition to turbulence in flow down a pipe.https://cassyni-user-files-prod.s3.amazonaws.com/8hzneoWc22Cfy1whnv86iS