CNTN4 modulates neural elongation through interplay with APP - presented by Dr Asami Oguro-Ando PhD and Dr. Ricardo Marquez Gomez

CNTN4 modulates neural elongation through interplay with APP

Dr Asami Oguro-Ando PhD

Dr Asami Oguro-Ando PhD
Open Biology

Associated Open Biology article

R. A. Bamford et al. (2024) CNTN4 modulates neural elongation through interplay with APP. Open Biology
Article of record
CNTN4 modulates neural elongation through interplay with APP
Dr Asami Oguro-Ando PhD
Asami Oguro-Ando
University of Exeter
Chaired by Ricardo Marquez Gomez

The neuronal cell adhesion molecule contactin-4 (CNTN4) is genetically associated with autism spectrum disorder (ASD) and other psychiatric disorders. Cntn4-deficient mouse models have previously shown that CNTN4 plays important roles in axon guidance and synaptic plasticity in the hippocampus. However, the pathogenesis and functional role of CNTN4 in the cortex has not yet been investigated. Our study found a reduction in cortical thickness in the motor cortex of Cntn4 −/− mice, but cortical cell migration and differentiation were unaffected. Significant morphological changes were observed in neurons in the M1 region of the motor cortex, indicating that CNTN4 is also involved in the morphology and spine density of neurons in the motor cortex. Furthermore, mass spectrometry analysis identified an interaction partner for CNTN4, confirming an interaction between CNTN4 and amyloid-precursor protein (APP). Knockout human cells for CNTN4 and/or APP revealed a relationship between CNTN4 and APP. This study demonstrates that CNTN4 contributes to cortical development and that binding and interplay with APP controls neural elongation. This is an important finding for understanding the physiological function of APP, a key protein for Alzheimer’s disease. The binding between CNTN4 and APP, which is involved in neurodevelopment, is essential for healthy nerve outgrowth.

Image credit: ManuelSchottdorf

References
  • 1.
    R. A. Bamford et al. (2024) CNTN4 modulates neural elongation through interplay with APP. Open Biology
  • 2.
    A. Oguro-Ando et al. (2021) Cntn4, a risk gene for neuropsychiatric disorders, modulates hippocampal synaptic plasticity and behavior. Translational Psychiatry
  • 3.
    R. A. Bamford et al. (2019) The Interaction Between Contactin and Amyloid Precursor Protein and Its Role in Alzheimer’s Disease. Neuroscience
  • 4.
    M. Eve et al. (2022) Neuronal Cell Adhesion Molecules May Mediate Neuroinflammation in Autism Spectrum Disorder. Frontiers in Psychiatry
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A. Oguro-Ando (2024, August 19), CNTN4 modulates neural elongation through interplay with APP
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