Succinic semialdehyde derived from the gut microbiota can promote the proliferation of adult T-cell leukemia/lymphoma cells - presented by Ms. Nodoka Chiba

Succinic semialdehyde derived from the gut microbiota can promote the proliferation of adult T-cell leukemia/lymphoma cells

Ms. Nodoka Chiba

MVIF 36 - with keynote talk by Prof. Ruixin Liu

Host

Microbiome Virtual International Forum

DateTuesday, February 18, 2025 12:30 AM

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Microbiome Virtual International Forum

Slide at 03:33

Result 2: taxonomic compositional data analysis
Seven genera were significantly higher in ATL
patients and high-risk carriers
Eubacterium
Unassigned40
Alistipes A
Klebsiella
p = 0.0121
- 0.0326
Differential analysis of taxonomic profiles
10th
p= 0.0312
p = 0.0178
10-2
10-2
Healthy
ATL patients
10-1
controls +
Desulfovibrio
Eubacterium G
Unassigned577
Low-risk
High-risk
p = 0.0343
Carriers
Carriers
10th
p = 0.0335
p=0.0419
N=49
N=19
10th
10-3
Two-sided Brunner-Munzel test
Significance level; P=0.05
H+C A+HiC
A+HiC
H+C A+HiC
High-risk =
Candidate genera that might relate to ATL
SIL-2Ra(Tumor maker) > clinical criteria of ATL
onset/progression
8/16

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Summary (AI generated)

The analysis identified two specific bacteria that may be correlated with two additional markers of ATL.