An update on the 12 Labours DigitalTWINS platform for supporting clinical translation of computational physiology workflows

This seminar will present our latest efforts towards developing a Physiome modelling platform for precision medicine - the 12 Labours DigitalTWINS platform (Digital Translational Workflows for INtegrating Systems). We are building this platform to support clinical translation of computational physiology workflows and the development of personalised digital twins of patients. We will describe how we are storing data within the platform using a FAIR data management system and the FHIR clinical standard for 12 Labours exemplar projects. These include workflows for diagnosis of breast cancer and pulmonary hypertension. We also present efforts towards creating a unified clinical data management plan that can be used by researchers in their ethics applications. These efforts aim to maximise the secondary use and linking of data, which is essential for integrating workflows being developed by different research groups to create integrated virtual human twins.