My Digital Gut: a tool set for microbiome-mediated precision nutrition - Pacific event

Variable responses to diet are mediated, to a large degree, by inter-individual variation in the composition of the gut microbiota. However, mapping ecological composition of the gut microbiome to its functional outputs, at scale, in the context of individual-specific dietary intake poses a daunting challenge. Furthermore, tracking dietary intake through gold-standard questionnaires is costly, requires high levels of compliance from participants, and is prone to reporting biases. In this talk, I present recent progress towards building a gut digital twin, which can be used to simulate personalized responses to dietary and probiotic interventions. I also present a novel data-driven diet tracking tool, which can be leveraged to estimate dietary intake directly from stool metagenomic data. Together, these tools are designed to empower high-throughput, microbiome-mediated precision nutrition.