Evolution of design approaches in asymmetric organocatalysis over the last decade

This seminar intends to cover the vast field of asymmetric organocatalysis and its evolution during the last ten years, evaluating the corresponding timeline of the progression of the field concerning the main synthetic approaches as well as the ground-breaking synergetic approach between experimental and computational methods. With the combination of an evolutionary trend and the expansion of computing technology, further advancements in the field of asymmetric organocatalysis are undeniable. In addition, a theoretical study on the computationally led design of catalysts within phase transfer catalysis and halogen bond-based catalysis will be presented. The delicate balance between steric and attractive Non-Covalent Interactions (NCIs), as the main controlling factors, in organocatalysis will be examined.