Base-Metal Catalysis - presented by Prof. Lingling Chu and Assoc. Prof. Ming Joo Koh and Prof. Zhan Lu and Assoc. Prof. Tatsuhiko Yoshino and Prof. Naohiko Yoshikai

Base-Metal Catalysis

Lingling Chu, Ming Joo Koh, Zhan Lu and Tatsuhiko Yoshino

Prof. Lingling ChuAssoc. Prof. Ming Joo KohAssoc. Prof. Tatsuhiko YoshinoProf. Zhan Lu
Slide at 20:07
New Strategy for Asymmetric Radical Couplings Chelation strategy Sensitization strategy tetrahedral excited state photoexcitation planar rigid nickel complex ground state favored reductive elimination Chelation effect: Trapping radical with excited Ni(II) complex: Facilitating stereoselective radical capture Modulating the geometries of nickel complexes Impeding the reversible Ni-C bond homolysis Enhanced reactivity and diversed selectivity via EnT Enhancing the rigidity of Ni(III) intermediate Less-exploited stereoselective control at excited Ni J. Am. Chem. Soc. 2020, 142, 9604. ACS Catal 2022, 12, 9779 J. Am. Chem. Soc. 2020, 142, 20390 Chem 2022, 9, 154 J. Am. Chem. Soc. 2023, in revision Angew Chem. Int. Ed. 2022, e202116725 J. Am. Chem. Soc. 2023, 145, 9876 Nat. Commun 2023, 55 Angew Chem. Int. Ed. 2023, e202305426 Angew. Chem. Int. Ed. 2021, 26511 Angew. Chem. Int. Ed. 2019, 177
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References
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    H. Tu et al. (2020) Enantioselective Three-Component Fluoroalkylarylation of Unactivated Olefins through Nickel-Catalyzed Cross-Electrophile Coupling. Journal of the American Chemical Society
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    J. Am. Chem. Soc. 2023, in revision
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    X. Li et al. (2022) Three-component enantioselective alkenylation of organophosphonates via nickel metallaphotoredox catalysis. Chem
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Summary (AI generated)

The change in the gene of the Nickel complex could allow for a selective radical capture process. Four excitations would enhance activity and selectivity through single electron or energy transfers. Selective control is important in photo-excited states.

In 2016, our group was interested in multi-component cross couplings because they can efficiently build complex molecules using simple materials. We anticipated that radical species would bring distinct activities and selectivity to these reactions. However, progress in this area has been slow due to the presence of multiple types of radical species, making it challenging to use a single Transition Metal catalyst to control the selectivity.