Base-Metal Catalysis - presented by Prof. Lingling Chu and Assoc. Prof. Ming Joo Koh and Prof. Zhan Lu and Assoc. Prof. Tatsuhiko Yoshino and Prof. Naohiko Yoshikai

Base-Metal Catalysis

Lingling Chu, Ming Joo Koh, Zhan Lu and Tatsuhiko Yoshino

Prof. Lingling ChuAssoc. Prof. Ming Joo KohAssoc. Prof. Tatsuhiko YoshinoProf. Zhan Lu
Slide at 34:55
Asymmetric Radical Multicomponent Couplings via Sensitization DFT calculations elucidating stereoselectivity CO2Me MeO2C CO2Me CO2Me suBe N111. N11.. AG ==2.5 Ni"-Ar Ni". reversible stereodeterming Ni-C bond homolysis planar, ground state tetrahedral, excited-state facile R.E. Parallel cross-electrophile reaction at ground state NCI analysis NiCl2-DME (10 mol%) (S,S)-sec-Bu-BiOx Bu-Br (13 mol%) Mn, DMA, rt CO2Me dark CO2Me 13% yield, 45% ee Decreased yield and enantioselectivity with ground state Ni(II) Noncovalent interactions are important to enantioselective control J. Am. Chem. Soc. 2020, 142, 20390.
1
References
  • 1.
    L. Guo et al. (2020) General Method for Enantioselective Three-Component Carboarylation of Alkenes Enabled by Visible-Light Dual Photoredox/Nickel Catalysis. Journal of the American Chemical Society
Share slide