Base-Metal Catalysis - presented by Prof. Lingling Chu and Assoc. Prof. Ming Joo Koh and Prof. Zhan Lu and Assoc. Prof. Tatsuhiko Yoshino and Prof. Naohiko Yoshikai

Base-Metal Catalysis

Lingling Chu, Ming Joo Koh, Zhan Lu and Tatsuhiko Yoshino

Prof. Lingling ChuAssoc. Prof. Ming Joo KohAssoc. Prof. Tatsuhiko YoshinoProf. Zhan Lu
Slide at 31:42
Asymmetric Radical Multicomponent Couplings via Sensitization Asymmetric radical 3-component coupling of alkenes 70%, 94% ee 67%, 93% ee 71%, 94% ee 55%, 91% ee 81% yield, 95% ee R3 BF3K R2 R1 67%, 95% ee 61%, 96% ee 85%, 94% ee (d.r. 1:1) 41%, 90% ee 64%, 90% ee 16%, 87% ee 82%, 90% ee 82%, 90% ee 84%, 83% ee 76%, 89% ee (d.r. 6:1) J. Am. Chem. Soc. 2020, 142, 20390.
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References
  • 1.
    L. Guo et al. (2020) General Method for Enantioselective Three-Component Carboarylation of Alkenes Enabled by Visible-Light Dual Photoredox/Nickel Catalysis. Journal of the American Chemical Society
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Summary (AI generated)

These photoredox catalysts offer a more benign protocol for accessing valuable structures under mild conditions. The Multicomponent reaction mode allows for modulation and easy access to a library of variables. For example, changing the structure of LQ traveler bo and using L kins and braide can easily produce derivatives of the fibro with high efficiency and excellent initial selectivity control.