The human virome in health and disease - presented by Prof. Frederic Bushman

The human virome in health and disease

Prof. Frederic Bushman

Prof. Frederic Bushman
Slide at 19:53
Association of Redondoviruses with periodontitis and critical illness 40 35 8 p = 0.014 p = 0.028 Healthy Critically ill Critically ill Negative Positive oropharynx oropharynx lung controls controls LUNG PHARYNX Patient 1 Periodontitis Recovered STOOL LUNG Disease Status Periodontitis Improvement PHARYNX Patient 2 STOOL LUNG PHARYNX Patient 3 STOOL LUNG PHARYNX Patient 4 STOOL Exclusively human LUNG PHARYNX Patient 5 STOOL High in periodontitis, falls with treatment LUNG PHARYNX Patient 6 STOOL Present in high absolute levels in critically ill patients Days Post ICU Admittance Detection studio.streamyard.com is sharing your screen Stop sharing Hide
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References
  • 1.
    A. A. Abbas et al. (2019) Redondoviridae, a Family of Small, Circular DNA Viruses of the Human Oro-Respiratory Tract Associated with Periodontitis and Critical Illness. Cell Host & Microbe
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Summary (AI generated)

We conducted our own QPCR studies on critically ill patients in the hospital system at Penn. Our results showed high-level colonization, indicating a cycle of threshold. Low levels were found in the oropharynx or lung of critically ill patients, suggesting long-term persistence related to disease.