The human virome in health and disease - presented by Prof. Frederic Bushman

The human virome in health and disease

Prof. Frederic Bushman

Prof. Frederic Bushman
Slide at 17:51
Discovery of a New Virus Family in the Human Lung Two transplant donor-recipient pairs 13-17 13-28 Anelloviridae Baculoviridae Circovindae Genomoviridae Herpesviridae Indovindae Log10 Read Pairs Papiliomavindae 3,062 Parvoviridae Phycodnaviridae Porcine stool-associated circular Polyomavindae virus 5 Inovindae Microyiridae Myovinidae Started with a weak hit to an Podoviridae Siphoviridae unstudied pig CRESS virus -1 0 128161304 -1 0 83 166 Days Post Transplantation lor et al., Cell Host and Microbe, 2019 studio.streamyard.com is sharing your screen Stop sharing Hide
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References
  • 1.
    A. A. Abbas et al. (2019) Redondoviridae, a Family of Small, Circular DNA Viruses of the Human Oro-Respiratory Tract Associated with Periodontitis and Critical Illness. Cell Host & Microbe
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Summary (AI generated)

We began studying human airway samples during lung transplants. We had two donor-recipient pairs and the students conducting the research noticed a circovirus present. Circoviruses are known as agricultural pathogens and are pathogenic in pigs. This discovery caught our attention. Through database alignment, it was determined that the reads found aligned with a little-known pig virus called porcine stool associated circular virus five. This virus appears to be a CRESS virus, a circular rep encoding single strand DNA virus that has not been extensively studied. When attempting to assemble the reads, the students were able to generate some very detailed genomes.