Base-Metal Catalysis - presented by Prof. Lingling Chu and Assoc. Prof. Ming Joo Koh and Prof. Zhan Lu and Assoc. Prof. Tatsuhiko Yoshino and Prof. Naohiko Yoshikai

Base-Metal Catalysis

Lingling Chu, Ming Joo Koh, Zhan Lu and Tatsuhiko Yoshino

Prof. Lingling ChuAssoc. Prof. Ming Joo KohAssoc. Prof. Tatsuhiko YoshinoProf. Zhan Lu
Slide at 1:03:39
11,2-Hydrocarbofunctionalization of alkenes by NHC-Ni catalysis Switch organometallic nucleophile to hydride donor greater steric repulsion NHC-Ni catalyst [Ni] G2 R LG [Ni] [Ni] TS A (favored) TS A' (disfavored) Catalyst Control M R' (M = MgX, G2 R ZnX) Wang, H. et al. Nat. Chem. 2022, 14, 188. Dicarbofunctionalization
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References
  • 1.
    H. Wang et al. (2021) Directing-group-free catalytic dicarbofunctionalization of unactivated alkenes. Nature Chemistry
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Summary (AI generated)

We expanded the scope of Hydrofunctionalization by using various types of Alkanes, including unactivated Alkanes and Hector at sub Alkanes. These Hydrofunctionalization Products only work for cyclic Alkanes that are less hindered than aromatic groups.