Base-Metal Catalysis - presented by Prof. Lingling Chu and Assoc. Prof. Ming Joo Koh and Prof. Zhan Lu and Assoc. Prof. Tatsuhiko Yoshino and Prof. Naohiko Yoshikai

Base-Metal Catalysis

Lingling Chu, Ming Joo Koh, Zhan Lu and Tatsuhiko Yoshino

Prof. Lingling ChuAssoc. Prof. Ming Joo KohAssoc. Prof. Tatsuhiko YoshinoProf. Zhan Lu
Slide at 1:03:48
1,2-Hydrocarbofunctionalization of alkenes by NHC-Ni catalysis Switch organometallic nucleophile to hydride donor G2 R Hydrocarbofunctionalization Liu, C.-F. et al. JACS, 2021, 143, 9498. greater steric repulsion NHC-Ni catalyst [Ni] G2 R LG [Ni] [Ni] TS A (favored) TS A' (disfavored) Catalyst Control
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References
  • 1.
    C. Liu et al. (2021) Catalytic Regioselective Olefin Hydroarylation(alkenylation) by Sequential Carbonickelation-Hydride Transfer. Journal of the American Chemical Society
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Summary (AI generated)

We could install aromatic groups and alkyl groups onto these alkanes to increase their visual activity. These reactions can simplify the synthesis of bioactive compounds, such as compound 10, which belongs to a family of narcotics. This model allows us to access intermediates selectively using static control.