Base-Metal Catalysis - presented by Prof. Lingling Chu and Assoc. Prof. Ming Joo Koh and Prof. Zhan Lu and Assoc. Prof. Tatsuhiko Yoshino and Prof. Naohiko Yoshikai

Base-Metal Catalysis

Lingling Chu, Ming Joo Koh, Zhan Lu and Tatsuhiko Yoshino

Slide at 1:04:26

1,2-Hydrocarbofunctionalization of alkenes by
NHC-Ni catalysis
Representative scope
Hydroarylation (triflates)
Me Ar
Ar = 4-Me-C6H4
Ar H
MePh2Si
i-Pr
48% >99:1 ..
42% 85:15
Me Ar
61% 93:7
71% >99:1 r.r., >98:2 d.r.
(from vitamin E, antioxidant)
(from androstanolone, androgen)
85% 98:2 r.r.
62% 99:1 r.r.
Hydroarylation (bromides)
Hydroalkenylation (triflates)
Bioactive molecule synthesis
N-NMe
67% 96:4 r.r.
43% 92:8 r.r.
45% 91:9 r.r.
51% 89:11 r.r.
42% >99:1 r.r.
(narcotic agonists)
98:2 r.r., >98:2 d.r.

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Summary (AI generated)

By manipulating the groups on intermediate A, we can form a compound with a β S bond. This compound can undergo a bitter hydro elimination to produce an almar. This process could potentially result in a trice up to. The same strategy can be applied to other compounds.