Base-Metal Catalysis - presented by Prof. Lingling Chu and Assoc. Prof. Ming Joo Koh and Prof. Zhan Lu and Assoc. Prof. Tatsuhiko Yoshino and Prof. Naohiko Yoshikai

Base-Metal Catalysis

Lingling Chu, Ming Joo Koh, Zhan Lu and Tatsuhiko Yoshino

Prof. Lingling ChuAssoc. Prof. Ming Joo KohAssoc. Prof. Tatsuhiko YoshinoProf. Zhan Lu
Slide at 1:07:53
Enantioselective carbofunctionalization of alkenes by chiral NHC-Ni catalysis C2-symmetric chiral NHC ligands induce high regio- and enantioselectivity Ni(0) catalyst With Shi group (SIOC) L[Ni]-G1 G1-OTf H(G2) [Ni]L NaOiPr R1 = alkyl, aryl, alkenyl, alkoxy, amino, silyl L=NHC R2 = H, alkyl G2-M G' 1 = aryl, alkenyl G2 = aryl, alkenyl, alkyl chiral NHC ligand (a) Liu, C.-F. et al. Nat. Catal. 2022, 5, 934. (b) Wang, Z.-C. et al. Nat. Catal. 2023, in press.
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References
  • 1.
    C. Liu et al. (2022) Synthesis of tri- and tetrasubstituted stereocentres by nickel-catalysed enantioselective olefin cross-couplings. Nature Catalysis
  • 2.
    Z. Wang et al. (2023) Enantioselective C–C cross-coupling of unactivated alkenes. Nature Catalysis
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Summary (AI generated)

Access the single tumor of the carbon LQ Nickel species is necessary. Function the carbon Nickel bond to install different functionalities and create compounds in a high-enriched fashion. This process allows for the production of various products through selective couple function organizations. By functionalizing and activating alkanes, one can generate highly selective inter internet alkanes, including unactivated alkanes. While cyclic alkanes are less efficient, there is one example where internal alkynes can be used.