Emerging Trends in Glycoscience, Part #1

The methods are very appealing for application in the industry. One notable group from the CIF, led by Doctor Pinto Mandal, reported a stereoselective α C glycosylation schedule for a variety of glycols using trimethyl and propargyl phenyl acetylene via simultaneous bora activation of the glycosyl donor using pre-pentafluoroborate. The desired compounds were isolated in high yield with excellent α selectivity.

Another significant work comes from the late Professor A. K. Prasad from the University of Delhi. This paper was submitted on February 7, 2023. Unfortunately, on February 8, we received the sad news that he had passed away. His paper marked the last of his career. Professor Rao Prasad and his group developed a chemoenzymatic synthesis of arabino-configured bicyclic nucleosides. The biological significance of nucleosides, the building blocks for nucleic acids, can be tailored by chemically modifying the C-5 carbon sugars to influence its sugar puckering. Additionally, this group established a chemotic convergent route to the high-yielding synthesis of bicyclic nucleosides.