The human virome in health and disease

Prof. Frederic Bushman

Slide at 13:39

Correlating the abundance of isolated bacteria and their
induced phages
10 1
P = 0.0008
Phages from more abundant bacteria
R = 0.53
are more abundant in infant stool
Conclusion: prophage induction from
10-3
pioneer bacteria provides an explanation for the source of the
observed early life virome
community
10-6
Evidence for later colonization with
lytic phages
Isolated bacterial abundance (%)
in gut commu
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Summary (AI generated)

We believe that prophage induction from pioneer bacteria is the main mechanism behind the observed early life virome community. Initially, bacteria colonize the baby and commonly have integrated prophage that induce periodically. This results in the first population of viruses that we observe. As time progresses, we may see more lytic phages present in the community.