Sensing Physical Signals with Cytoskeletal Dynamics - presented by Prof. Wolfgang Losert

Sensing Physical Signals with Cytoskeletal Dynamics

Prof. Wolfgang Losert

Prof. Wolfgang Losert
Slide at 39:42
Model Predictions Wolfgang Losert Moves Down Sawteeth Moves Up Sawteeth 8 um 8 um 8 um Time 6000 4000 Movement Up Sawteeth for high polymerization rate or contractility 2000 Seconday bias toward perpendicular elongation and/or motion Cell Elongation Angle Herr et al , CommsPhys (2022)
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References
  • 1.
    C. Herr et al. (2022) Spontaneous polarization and cell guidance on asymmetric nanotopography. Communications Physics
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Summary (AI generated)

In phase field simulations, it is possible to change the preferred direction of cells by altering the mechanical or chemical activity. Igor Aronson from Penn State suggested that cells may move perpendicularly to AAA texture, which seemed like a strange prediction at the time. However, further investigation revealed that there is indeed a small preferred peak of cells, and they sometimes move perpendicularly instead of only parallel to the ridges.