The human virome in health and disease - presented by Prof. Frederic Bushman

The human virome in health and disease

Prof. Frederic Bushman

Prof. Frederic Bushman
Slide at 06:40
Development of the human virome in healthy newborn infants Lim et al. 2018: No detectable virome in amniotic fluid in healthy pregnancies Breitbart et al. 2008. Study of one infant. No detectable particles in meconium by microscopy, but 108 VLPs per gram of stool by one week of life Additional studies: stool samples taken an average of 37 hours or 2.6 days after birth show high levels of particles Conclusion: few or no particles at birth, rapid colonization later Stability of the human virome later in life Multiple studies report abundant VLPs in adult feces Longitudinal studies: viral communities generally stable for at least a year, paralleling results with the cellular microbiome (Minot et al. 2013, Shkoporov et al. 2019) Conclusion: abundant communities in healthy adults with notable longitudinal stability studio.streamyard.com is sharing your screen Stop sharing Hide
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References
  • 1.
    E. S. Lim et al. (2018) Amniotic fluid from healthy term pregnancies does not harbor a detectable microbial community. Microbiome
  • 2.
    M. Breitbart et al. (2008) Viral diversity and dynamics in an infant gut. Research in Microbiology
  • 3.
    S. Minot et al. (2013) Rapid evolution of the human gut virome. Proceedings of the National Academy of Sciences
  • 4.
    A. N. Shkoporov et al. (2019) The Human Gut Virome Is Highly Diverse, Stable, and Individual Specific. Cell Host & Microbe
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Summary (AI generated)

The development of the virome in healthy newborns has been studied by various researchers. Lim et al. found no virome in amniotic fluid in healthy pregnancies. The focus of our discussion will be on the virome in healthy infants, as viral infections can severely impact neonatal health. Breitbart et al. conducted a study on one infant and initially found no particles in meconium, but later observed measurable levels. Other studies have shown that high levels of viral particles can be detected in baby stool within 37 hours to two days after birth. Overall, it appears that there are few to no particles present at birth, with rapid colonization occurring shortly after. The virome remains stable later in life, as supported by several studies on microbial colonization of newborns.