The human virome in health and disease - presented by Prof. Frederic Bushman

The human virome in health and disease

Prof. Frederic Bushman

Prof. Frederic Bushman
Slide at 16:13
The viral colonization in early life is stepwise Month 4 Bacterial Formula Month 0 Month 1 colonists, Viruses of Phage : human cells induction Breast milk Inhibited by breastfeeding Healthy babies are usually sterile at birth The first phase is characterized by induction of prophage from pioneer bacteria A subsequent step involves colonization with viruses infecting human cells, which could be modulated by breastfeeding The protective effects of breastfeeding could be validated in cohorts from both studio.streamyard.com is sharing your screen Stop sharing Hide (Liang et al., Nature, 2020)
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References
  • 1.
    G. Liang et al. (2020) The stepwise assembly of the neonatal virome is modulated by breastfeeding. Nature
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Summary (AI generated)

In summary, viral colonization in early life appears to occur in a stepwise manner. Healthy babies are typically sterile at birth. The first phase involves the induction of prophage from pioneer bacteria. Subsequently, colonization with viruses infecting human cells occurs, which may be influenced by breastfeeding. The protective effects of breastfeeding have been observed in cohorts from both the US and Africa. Mixed feeding of breast milk and formula has been shown to have a significant suppressive effect on animal cell viruses. This provides encouragement for new mothers to breastfeed as much as possible, even if exclusive breastfeeding is not feasible.