The human virome in health and disease - presented by Prof. Frederic Bushman

The human virome in health and disease

Prof. Frederic Bushman

Prof. Frederic Bushman
Slide at 21:42
Microbial signatures Figure 5 Oropharyngeal Nasopharyngeal swab swab associated with 1.00 Small circular virus Cutibacterium Prevotella Staphylococcus Actinomyces Prevotella Rothia 0.75 Corynebacterium severity Alloprevotella Anaerococcus Mycoplasma Lactobacillales Intubation Dialister Mycoplasma 0.50 Leptotrichia Streptococcus Capnocytophaga Atopobium Use multiple data types to Sample types Veillonella Rothia Oropharyngeal swab 0.25 Cutibacterium Alloprevotella predict intubation or disease (AUROC=0.86) Streptococcus Nasopharyngeal swab Actinomyces (AUROC=0.80) Fretibacterium Neisseriaceae severity (maximum WHO Corynebacterium Lawsonella 0.00 Campylobacter Enterococcus score) in COVID patients. 0.00 0.25 0.50 0.75 1.00 False positive rate Importance score Importance score Oropharyngeal Nasopharyngeal Presence of small circular swab swab 1.00 Actinomyces Anaerococcus viruses quantitatively most Rothia Cutibacterium Haemophilus Corynebacterium prominent predictor for Veillonella 0.75 Staphylococcus Leptotrichia Prevotella Small circular virus Mycoplasma intubation. Max WHO Score Prevotella Streptococcus 0.50 Lactobacillales Rothia Streptococcus Atopobium Sample types Staphylococcus Dialister Connection with disease Oropharyngeal swab 0.25 Capnocytophaga Lawsonella (AUROC=0.82) Cutibacterium Nasopharyngeal swab Alloprevotella under investigation- (AUROC=0.75) Neisseria Pseudomonas Gemella Actinomyces 0.00 Alloprevotella Lactobacillales potential outgrowth in early 0.00 0.25 0.50 0.75 1.00 development of False positive rate Importance score Importance score inflammation? studio.streamyard.com is sharing your screen Stop sharing Hide Merenstein et al., 2021 mBio
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References
  • 1.
    C. Merenstein et al. (2021) Signatures of COVID-19 Severity and Immune Response in the Respiratory Tract Microbiome. mBio
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Summary (AI generated)

A notable predictor for WHO score, we obtained a good area under the curves in each case. There appears to be a connection between these predictors and disease. It is possible that an inflammatory condition is conducive to the growth of these viruses. We are currently investigating the cells on which these viruses grow, with a preference for human cells or human-associated eukaryotes. We are working to gather final data on this topic. Stay tuned for updates.