The human virome in health and disease - presented by Prof. Frederic Bushman

The human virome in health and disease

Prof. Frederic Bushman

Prof. Frederic Bushman
Slide at 21:08
Figure 4 Nasopharyngeal Oropharyngeal Endotracheal swab swab aspirate score Commensal human Viruses Anello Redondo Both Neither viruses in COVID-19 p=0.001 Most abundant taxon Actinobacteriora Coryn Actinobacteriota Cutibe Actinobacteriora Rothia Bacteroidota Prevotella Firmicules Enterococa Firmicules Mycoplasm Firmicules Staphylococ Firmicules Streptococc Non COVID Detailed study of respiratory microbiome in Other Prolocbacteria Neisser 83 hospitalized COVID patients (507 Protecbacteria Pseudo Percent samples). 0.25 0.50 0.75 1.00 Notable signals associated with bacterial Intubated lineages and disease severity. p = 0.0007 Analyzed commensal human-associated viruses Anelloviridae and Redondoviridae using targeted qPCR. Anelloviridae and Redondoviridae elevated in intubated patients. Intubated Merenstein et al., 2021 mBio studio.streamyard.com is sharing your screen Stop sharing Hide
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References
  • 1.
    C. Merenstein et al. (2021) Signatures of COVID-19 Severity and Immune Response in the Respiratory Tract Microbiome. mBio
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Summary (AI generated)

Respiratory samples from COVID patients were studied, revealing that Redondoviruses are prominent features. A recent paper was published on a study of 83 hospitalized patients and 507 samples, which included targeted qPCR for Anelloviridae and Redondoviridae. It was found that Redondoviridae were significantly higher among intubated patients, while Anelloviridae, considered commensals, were also high. The small circular viruses were the strongest predictor for intubation when attempting to predict the severity of disease, either as intubation or the WHO score in COVID.