Real-time multicompartment Hodgkin-Huxley neuron emulation on SoC FPGA

The comparisons between the logical model and the logical recordings, as well as our model, are as follows. We use 512 neurons per organoid, including excitatory and inhibitory neurons, and we conduct an emulation for 5 minutes. During this 5-minute emulation, the hardware operates in real time, allowing for monitoring of all spikes on board. This real-time operation results in the same outcomes as observed in logical recordings.

When a single organoid is present, two different dynamics are observed. As organoids are assembled or connected, they begin to form connections and create a network. Additionally, we introduce chemical inhibition or excitation, such as choline or CQNX, to the emulation process. By doing so, we are able to achieve results that are consistent with biological responses, enabling us to inhibit or stimulate our network effectively.