Base-Metal Catalysis - presented by Prof. Lingling Chu and Assoc. Prof. Ming Joo Koh and Prof. Zhan Lu and Assoc. Prof. Tatsuhiko Yoshino and Prof. Naohiko Yoshikai

Base-Metal Catalysis

Lingling Chu, Ming Joo Koh, Zhan Lu and Tatsuhiko Yoshino

Prof. Lingling ChuAssoc. Prof. Ming Joo KohAssoc. Prof. Tatsuhiko YoshinoProf. Zhan Lu
Slide at 1:47:06
Modification of Backbone
O.S.NH
Cp*Co(CO)I2 (10 mol%)
Chiral Acid (10 mol%)
AgOTf (20 mol%)
AcOH
MS 5A
(10.0 equiv.)
O.S.
tAmOH, 30 °C, 20 h
toluene, 110 °C
24 h
CO2H
CO2H
Binaphthyl
H8 Binaphthyl
75%, 94:6 er
77%, 96:4 er
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Summary (AI generated)

Furthermore, we found that the hydrobin backbone is slightly better than the bin after backbone. We achieved a 96% yield for this reaction.