Roundtable on Black in cancer research and oncology - presented by Dr. Brandon Blue MD and Dr. Kilan Ashad-Bishop and Drs. Onyinye and Folu Balogun and Runcie C.W. Chidebe Dip., BSc., MSc., and Kathryn Mcginnis and Dr Paraskevi Mallini and Dr. Lisa Hoffmann-Haas

Roundtable on Black in cancer research and oncology

Brandon Blue, Kilan Ashad-Bishop, Onyinye and Folu Balogun and Runcie C.W. Chidebe

Dr. Brandon Blue MDDr. Kilan Ashad-BishopDrs. Onyinye and Folu BalogunRuncie C.W. Chidebe Dip., BSc., MSc.,
Slide at 03:27
The Birth of the CAR Dr. Brandon Blue MD.45 STA STB STZ E/TRatio Time (hr) Proc. Natl. Acad. Sci. USA Vol. 90, pp. 720-724, January 1993 Immunology Specific activation and targeting of cytotoxic lymphocytes through chimeric single chains consisting of antibody-binding domains and the y or 5 subunits of the immunoglobulin and T-cell receptors (single-chain Fv domain/chimeric receptors/immunotargeting/Tcell) ZELIG ESHHAR*, TOVA WAKS, GIDEON GROSS AND DANIEL G. SCHINDLER
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References
  • 1.
    Z. Eshhar et al. (1993) Specific activation and targeting of cytotoxic lymphocytes through chimeric single chains consisting of antibody-binding domains and the gamma or zeta subunits of the immunoglobulin and T-cell receptors.. Proceedings of the National Academy of Sciences
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Summary (AI generated)

You can see that once the immune system is activated, these T cells really go to work. And honestly, that's what T cells do - they know that they should be killing. This is a very novel concept because T cells have always killed things. However, now we're just changing that target and allowing the immune system to be activated in a way that it fights off cancer cells.

Right now, this is really on the precipice of where most blood and bone marrow cancers are basically being treated. This is a way that is innate and almost a natural way to get rid of cancer or to get rid of extra cells that shouldn't necessarily be there in the body.