Roundtable on Black in cancer research and oncology - presented by Dr. Brandon Blue MD and Dr. Kilan Ashad-Bishop and Drs. Onyinye and Folu Balogun and Runcie C.W. Chidebe Dip., BSc., MSc., and Kathryn Mcginnis and Dr Paraskevi Mallini and Dr. Lisa Hoffmann-Haas

Roundtable on Black in cancer research and oncology

Brandon Blue, Kilan Ashad-Bishop, Onyinye and Folu Balogun and Runcie C.W. Chidebe

Dr. Brandon Blue MDDr. Kilan Ashad-BishopDrs. Onyinye and Folu BalogunRuncie C.W. Chidebe Dip., BSc., MSc.,
Slide at 03:49
A Splash of Cold Water Dr. Brandon Blue Over the next 10 years CARs were developed that targeted CD19, FRa, HER2/Neu, CEA, GD2, CD33, and PSMA. These showed consistent and robust CTL mediated killing. However, these studies were done mostly in vitro and with CTL clones Signals through T Cell Receptor-5 Chain Alone Are Insufficient to Prime Resting T Lymphocytes By Thomas Brocker and Klaus Karjalainen From the Basel Institute for Immunology, 4058 Basel, Switzerland
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References
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    T. Brocker and K. Karjalainen (1995) Signals through T cell receptor-zeta chain alone are insufficient to prime resting T lymphocytes.. Journal of Experimental Medicine
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Summary (AI generated)

And so, in this particular case, our goal is to refine and improve our systems and methods. This is an area of research that I focus on, as we are aware that cells communicate through different signaling pathways. Our aim is to ensure that these cells communicate with each other in a way that leads to sustained killing of abnormal cells. To illustrate, let's consider multiple Myeloma, a type of cancer that is currently being studied and developed. Unfortunately, it is not currently curable and mainly affects plasma cells in the bone marrow.

Our objective is to determine if CAR T cells, which are infused into the body, can continue to signal and communicate with each other. We want these cells to remain active long after they are introduced, so they can engage in immune surveillance and eliminate abnormal plasma cells. This information is crucial for those who seek a detailed understanding of the mechanisms involved. It is important to note that the immune system is typically triggered by certain cytokines in the body, which indicate the presence of a problem. For most individuals, this activation occurs in response to an infection.