Gut Microbiota and Obesity, Metabolic Regulation - presented by Ruixin Liu

Gut Microbiota and Obesity, Metabolic Regulation

Ruixin Liu

Ruixin Liu
MVIF 36 - with keynote talk by Prof. Ruixin Liu
Host
Microbiome Virtual International Forum
DateTuesday, February 18, 2025 1:00 AM
Permalinkcassyni.com/events/QZ4X4ZzLhyiEMM4peHb27F
Microbiome Virtual International Forum
Slide at 34:18
Summary: uncover the role of commensal bacteria in regulating lipid absorption or energy expenditure Obesity Energy Intake Energy Expenditure Appetite Absorption Thermogenesis Exercise Myo-inositol 1 Propionate1 Glutamate. M. rupellensis B. thetaiotaomicron A. muciniphila Nat Med 2017; Cell Host icrobe 2024b; Cell Metab 2025 streamyard.com#.
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References
  • 1.
    R. Liu et al. (2017) Gut microbiome and serum metabolome alterations in obesity and after weight-loss intervention. Nature Medicine
  • 2.
    X. Wang et al. (2023) Bacteroides methylmalonyl-CoA mutase produces propionate that promotes intestinal goblet cell differentiation and homeostasis. Cell Host & Microbe
  • 3.
    C. Wu et al. (2024) Obesity-enriched gut microbe degrades myo-inositol and promotes lipid absorption. Cell Host & Microbe
  • 4.
    Y. Zhang et al. (2025) Akkermansia muciniphila supplementation in patients with overweight/obese type 2 diabetes: Efficacy depends on its baseline levels in the gut. Cell Metabolism
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Summary (AI generated)

This study conveys two key messages. First, successful colonization through AKK supplementation occurs only in participants with low levels of Akkermansia muciniphila (AKK). Additionally, metabolic improvements are observed solely in these low AKK individuals. This underscores the importance of measuring AKK levels prior to any treatment or intervention involving AKK prebiotics, providing direct evidence for precision medicine guided by microbiota.

In summary, we have integrated findings from both human cohort studies and animal research to elucidate the role of certain commensal bacteria in regulating lipid absorption and energy expenditure, ultimately influencing the development of obesity. Our current objective is to identify regulatory methods to alter the abundance of these beneficial bacteria, with the hope of utilizing these insights in future obesity treatments.