Base-Metal Catalysis - presented by Prof. Lingling Chu and Assoc. Prof. Ming Joo Koh and Prof. Zhan Lu and Assoc. Prof. Tatsuhiko Yoshino and Prof. Naohiko Yoshikai

Base-Metal Catalysis

Lingling Chu, Ming Joo Koh, Zhan Lu and Tatsuhiko Yoshino

Prof. Lingling ChuAssoc. Prof. Ming Joo KohAssoc. Prof. Tatsuhiko YoshinoProf. Zhan Lu
Slide at 1:14:23
Enantioselective carbofunctionalization of
alkenes by chiral NHC-Ni catalysis
Ni(I)/Ni(III) vs. Ni(0)/Ni(II) pathways
Comparison of reaction mixtures using EPR studies
Ni(I) system
Ni(0) system
Ni-2 + alkene + triflate + NaOiPr
(b) Ni(cod)2/L1 alkene + triflate NaOiPr
Field (mT)
Field (mT)
Ni-2
Liu, C.-F. et al. Nat. Catal. 2022, 5, 934.
1
References
  • 1.
    C. Liu et al. (2022) Synthesis of tri- and tetrasubstituted stereocentres by nickel-catalysed enantioselective olefin cross-couplings. Nature Catalysis
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Summary (AI generated)

We are currently working on gaining more insights into the mechanism of the reaction. By using EPR studies, we have observed signals that suggest the generation of paramagnetic species like Nickel one or Nickel three. We believe that the Nickel zero N two cycle is dominant, but we cannot rule out Nickel one N three. Our calculations and PR studies support this hypothesis. We are still working on crystallizing the intermediate species to confirm their presence. Thank you for your attention. Next, we will have a demonstration of science of synthesis before introducing our next speaker. Science of synthesis is a comprehensive reference resource for synthetic methods, covering various types of organic and metallic compounds. It provides critical insights and practical advantages of different methods, making it a valuable tool for planning synthesis and exploring new areas. The content is organized into volumes based on product type and includes titles focused on emerging technologies in organic synthesis. You can explore the content through browsing, indexing, and searching tools on the website. Thank you for your interest, and we look forward to sharing more content with you in the future.