Base-Metal Catalysis - presented by Prof. Lingling Chu and Assoc. Prof. Ming Joo Koh and Prof. Zhan Lu and Assoc. Prof. Tatsuhiko Yoshino and Prof. Naohiko Yoshikai

Base-Metal Catalysis

Lingling Chu, Ming Joo Koh, Zhan Lu and Tatsuhiko Yoshino

Prof. Lingling ChuAssoc. Prof. Ming Joo KohAssoc. Prof. Tatsuhiko YoshinoProf. Zhan Lu
Slide at 39:51
Asymmetric Radical Multicomponent Couplings via Sensitization cis-Alkenyl products - PC-I O'Pr O'Pr O'Pr (S) 82% (15:1), 93% ee F 60% (7:1), 91% ee F 67% (Z), 92% ee 89% (13:1), 93% ee (R) 75% (8:1), 93% eea Br 75% (8:1), 91% ee CI 83% (Z), 92% ee trans-Alkenyl products - PC-II C6H4-CI CBH4-CI 'Bui 1.02 g 65% (E), 97% ee (w/ Br) 70% (1:10), 91% ee 71% (E), 98% ee (w/ ) 52% yield, 96% ee 71% (E), 96% ee (w/ ) Gram-scale > 70 examples, up to 98% ee Chem, 2023, 9, 154-169.
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References
  • 1.
    X. Li et al. (2022) Three-component enantioselective alkenylation of organophosphonates via nickel metallaphotoredox catalysis. Chem
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Summary (AI generated)

We can use paralytic phosphines in chemistry to synthesize a variety of biologically active LK or L kin phosphines. These phosphines can be easily manipulated with high ease.