Base-Metal Catalysis

Lingling Chu, Ming Joo Koh, Zhan Lu and Tatsuhiko Yoshino

Slide at 1:28:04

We prefer
M = Co/Rh/Ir (+3)
High stability
High reactivity and FG tolerance
Electrophilic activation (including AMLA/BIES/CMD)
R-H + M
R-M + H+
high-valent, electron-deficient, late transition metals
Pd(II), Pt(II), Rh(III), Ir(III), Ni(II), Cu(II/III), Co(III) etc.
Not very sensitive to air/moisture Compatible with oxidants, oxidative reagents, etc.
C-H functionalizations are often net oxidative reactions.

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Summary (AI generated)

The metal catalyst has a variable metal center. It is generally stable to air and moisture, making it compatible with oxidizing reaction conditions. In many synthetic reactions, functionalization reactions are often oxidations. It is interactive and compatible with transition metals.