Roundtable on Black in cancer research and oncology

Brandon Blue, Kilan Ashad-Bishop, Onyinye and Folu Balogun and Runcie C.W. Chidebe

Slide at 25:40

The Cancer Genome Atlas
Analysis of Uterine Cancers
chr.
The Onc Docs Dr. On.
Cluster 1
Cluster 2
Cluster 3
Cluster 4
Log-rank P = 0.0004
Cluster
Survival (months)
Cluster 1 "POLE mutant"
Different endometrial cancer subtypes based
on molecular/genetic profiling
Cluster 2 - "MSI-H"
Subtype affects disease recurrence
Cluster 3 - "Copy number low"
TP53 & ERBB2 mutations more frequent
in ECs from Black women
Cluster 4 - Copy number high
Methylation of ribosomal RNA genes and mutations in PTEN are less prevalent
Weill Cornell Medicine
Cancer Genome Atlas Research Network et al. Integrated genomic characterization of
endometrial carcinoma. Nature. 2013 May 2;497(7447):67-73.

References

1.
The Cancer Genome Atlas Research Network and D. A. Levine (2013) Integrated genomic characterization of endometrial carcinoma. Nature

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Summary (AI generated)

This is the Cancer Genome Atlas study for Uterine Cancers. It reveals that Uterine Cancers can be classified into four different classes based on their genomic profile. The Subtype of the cancer has an impact on disease recurrence. On the right-hand side, you can see that the Subtype called pole mutant has the best outcomes, followed by the Subtype called M si high. The Copy Number low Subtype comes next, and finally, the Copy Number high Subtype. It is known that black women are more likely to fall into the Copy Number high Subtype due to their higher prevalence of P53 and her two mutations.

To gain a better understanding of the underlying biological reasons for these disparities, I partnered with Dr. X from North Well Health and Cold Spring Harbor. Together, we developed a proposal to the New York Genome Center to study the mechanisms of ENDOMETRIAL CANCER DISPARITIES specifically in black women.