Synthetic Development of Key Intermediates and Active Pharmaceutical Ingredients: Next-generation strategies for the synthesis of functional, natural product inspired compounds - presented by Prof. Joydev Kumar Laha and Dr Luca Laraia | Unactivated Carboxylic Acids in Catalytic Asymmetric Ring Opening Reactions - presented by Dr. Nilanjana Majumdar PhD | The role of synthetic steps order in developing key intermediates and active pharmaceutical ingredients - presented by Dr. Gangarajula Sudhakar | Photocatalyzed Continuous-flow synthesis of Pharmaceuticals - presented by Dr. Sharada Prasanna Swain

Synthetic Development of Key Intermediates and Active Pharmaceutical Ingredients

Dr. Gangarajula SudhakarDr Luca LaraiaDr. Nilanjana Majumdar PhDDr. Sharada Prasanna Swain
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Regioselectivity: Outer Sphere vs Inner Sphere Mechanism (via a) (via b) (via c) [TM] [TM] Inner-Sphere [TM] Outer-Sphere [TM] Mechanism Mechanism [TM] [TM] Ir-catalysis Pd-catalysis Precoordination of 'Nu' to [TM]? Yes Precoordination of 'Nu' to [TM]? No Reductive elimination from carbon that best stabilizes (+)-charge Nucleophilic attack to least hindered carbon Branched product favored Linear product favored Trost, B. M.; Rao, M.; Dieskau, A. P.J. Am. Chem. Soc. 2013, 135, 18697-18704.
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References
  • 1.
    B. M. Trost et al. (2013) A Chiral Sulfoxide-Ligated Ruthenium Complex for Asymmetric Catalysis: Enantio- and Regioselective Allylic Substitution. Journal of the American Chemical Society
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