Breakdown and repair of metabolism in the aging brain - presented by Prof Henry Markram and Dr Polina Shichkova and Dr Dan Keller

Breakdown and repair of metabolism in the aging brain

Henry Markram, Polina Shichkova and Dan Keller

Dr Dan KellerProf Henry MarkramDr Polina Shichkova
Frontiers in Science Deep Dive series
Host
Frontiers in Science
DateWednesday, May 7, 2025 2:00 PM to 3:30 PM (UTC)
Frontiers in Science

Associated Frontiers in Science article

P. Shichkova et al. (2025) Breakdown and repair of metabolism in the aging brain. Frontiers in Science
Article of record
Breakdown and repair of metabolism in the aging brain
Prof Henry Markram
Henry Markram
École Polytechnique Fédérale de Lausanne
Dr Polina Shichkova
Polina Shichkova
Biognosys (Switzerland)
Dr Dan Keller
Dan Keller
Open Brain Institute

Modeling metabolism in the aging brain

A new open-source model of brain metabolism – the most complex ever built – shows how altering key chemicals through diet and exercise could restore resilience to aged brain cells. The model, published in a Frontiers in Science lead article, also reveals new targets for future dementia treatments.

Join the model’s creators and study authors for an in-depth discussion on the most comprehensive computer model of brain metabolism to date. Building on these findings, this Deep Dive reveals how the new model, available open-source to researchers via the Open Brain Platform , could accelerate research into interventions to protect and repair the aging brain, such as diet, exercise, and new drug targets.

Join us to learn how aging affects metabolism, neuronal activity, and blood flow in the brain, intricately mapped across 16,800 biochemical interactions. You’ll also have the chance to pose questions during the audience Q&A

Register here

References
  • 1.
    P. Shichkova et al. (2025) Breakdown and repair of metabolism in the aging brain. Frontiers in Science
Date & time
May
7
2025
Wednesday, May 7, 2025 2:00 PM to 3:30 PM (UTC)
Details
Listed seminar This seminar is open to all
Recorded Available to all
Disclaimer The views expressed in this seminar are those of the speakers and not necessarily those of the journal